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Sample records for single european market

  1. Has the European union achieved a single pharmaceutical market?

    PubMed

    Timur, Aysegul; Picone, Gabriel; DeSimone, Jeffrey

    2011-12-01

    This paper explores price differences in the European Union (EU) pharmaceutical market, the EU's fifth largest industry. With the aim of enhancing quality of life along with industry competitiveness and R&D capability, many EU directives have been adopted to achieve a single EU-wide pharmaceutical market. Using annual 1994-2003 data on prices of molecules that treat cardiovascular disease, we examine whether drug price dispersion has indeed decreased across five EU countries. Hedonic regressions show that over time, cross-country price differences between Germany and three of the four other EU sample countries, France, Italy and Spain, have declined, with relative prices in all three as well as the fourth country, UK, rising during the period. We interpret this as evidence that the EU has come closer to achieving a single pharmaceutical market in response to increasing European Commission coordination efforts.

  2. Do online pharmacies fit European internal markets?

    PubMed

    Mäkinen, Mia Maria; Rautava, Päivi Tuire; Forsström, Jari Johannes

    2005-05-01

    The aim of this article is to consider the suitability of online pharmacies into European internal market area. This required considering the models of present online pharmacies in respect to the existing legislation. Data on online pharmacy settings was collected by looking some online pharmacies, which were found by using Goggle search machine with term "online pharmacy" and by studying websites of some well-known online pharmacies. European legislation and policy were studied from European Union's official website. Online drug markets seem to be increasing in popularity for reasons related to their ready availability and cost benefits. Few online pharmacies are based in Europe, yet online markets are worldwide. Community legislation does not stipulate on the legality of online pharmacies on European internal markets. Instead Community legislation offers framework for electronic commerce that could also include online pharmacy practise. National legislation, however, may rule them out either directly or indirectly. Regardless of European internal markets online pharmacies' cross-border operations are particularly complicated. Preliminary ruling from the European Court of Justice concerning one European online pharmacy's cross-border practise is awaited 2003-2004 and will offer some aspects for future.

  3. Global integration of European tuna markets

    NASA Astrophysics Data System (ADS)

    Jiménez-Toribio, Ramòn; Guillotreau, Patrice; Mongruel, Rémi

    2010-07-01

    This paper evaluates the degree of integration between the world market and the major European marketplaces of frozen and canned tuna through both vertical and horizontal price relationships. Spatial linkages are investigated horizontally in order to estimate the connection between the European market and the world-wide market on the primary stage of the value chain. One of the key results is the high level of market integration at the ex-vessel stage, and the price leadership of yellowfin tuna over skipjack tuna. The same approach is applied at the ex-factory level. Basically, the European market for final goods appears to be segmented between the Northern countries consuming low-priced canned skipjack tuna imported from Asia (mainly Thailand) and the Southern countries (Italy, Spain) processing and importing yellowfin-based products sold at higher prices. France appears to be an intermediate market where both products are consumed. The former market is found to be well integrated to the world market and can be considered to be competitive, but there is a suspicion of market power being exercised on the latter. Price relationships are therefore tested vertically between the price of frozen tuna paid by the canneries and the price of canned fish in both Italy and France. The two species show an opposite pattern in prices transmission along the value chain: price changes along the chain are far better transmitted for the “global” skipjack tuna than for the more “European” yellowfin tuna. The results are discussed, along with their implications for the fishing industry.

  4. European Academic Labor Markets in Transition

    ERIC Educational Resources Information Center

    Musselin, Christine

    2005-01-01

    Even if convergences are to be observed among the orientations adopted by higher education policies in European countries, they still are characterized by strong national features. One of the most striking national patterns of each system is its academic labor market, salaries, status, recruitment procedures, workloads, career patterns, promotion…

  5. Multiple Hub Network Choice in the Liberalized European Market

    NASA Technical Reports Server (NTRS)

    Berechman, Joseph; deWit, Jaap

    1997-01-01

    . In the meantime, open skies agreements have been concluded between the USA and most of the EU member states to facilitate strategic alliances between airlines of the states involved. As a result of this on-going liberalization the model of the single 'national' carrier using the national home base as its single hub for the designated third, fourth and sixth freedom operations will stepwise disappear. Within the EU the concept of the national carrier has already been replaced by that of the community carrier. State ownership in more and more European carriers is reduced. On the longer run mergers or even bankruptcy will further undermine the "single national carrier - single national hub" model in Europe. In the meantime, strategic alliances between national carriers in Europe will already reduce the airlines' loyalty to a single airport. Profit maximization and accountability to share holders will supersede the loyalty of these newly emerging alliances, probably looking for the opportunities of a multiple hub network to adequately cover the whole European market. As a consequence, some European airports might see a substantial decline in arriving, departing and transfer traffic, thus in revenues and financial solvency, as well as in their connection to other inter-continental and intra-European destinations. At the same time, other airports might realize a significant increase in traffic as they will be sought after by the profit maximizing airlines as their major gateway hubs. Which will be the losing airports and which will be the winning ones? Can airports anticipate the actions of airlines in deregulated markets and utilize policies which will improve their relative position? If so, what should be these anticipatory policies? These questions become the more urgent, since an increasing number of major European airports will be privatized in the near future. Although increasing airport congestion in Europe will also be reflected in a growing demand pressure for

  6. [European integration and health policies: repercussions of the internal European Market on access to health services].

    PubMed

    Guimarães, Luisa; Giovanella, Lígia

    2006-09-01

    This article explores the health policy repercussions of countries' regional integration into the European Union. The aim is to review the regulation of access in other countries, with the conclusion of the single European market and the free circulation of persons, services, goods, and capital. The article begins by reviewing the various forms of integration and describes the expansion and institutionalization of Community agencies. The repercussions of European integration on health policies and regulation of access are analyzed. Market impacts on health result from Treaty directives and internal policy adjustments to free circulation. Health services access is gradually regulated and granted by rulings. Projects along borders illustrate the dynamics where differences are used to achieve comprehensive care. In the oldest integration experience, the market regulation has generated intentional and non-intentional impacts on the health policies of member states, regardless of the organizational model. Knowledge and analysis of this experience signals challenges for the Southern Cone Common Market (Mercosur) and adds to future debates and decisions.

  7. Competition and liberalization in European gas markets: Towards a continental European model

    SciTech Connect

    Stern, J.P.

    1998-06-01

    Many of the long-awaited changes to the European gas market are now imminent. Institutional developments and market forces are combining to produce a transformation. This major study analyzes the developments in a wide range of European countries, including central and eastern Europe. In examining how different institutional traditions and political priorities will affect the gas market, Stern explores the potential for a distinct continental European model of competition and liberalization.

  8. Barriers Impact U.S. Marketing to the European Community.

    ERIC Educational Resources Information Center

    Metzger, Leila

    For a quarter of a century, the United States has been gradually losing market share in the European Community, which accounts for about one-fifth of world trade. The European Community consumes about one-fourth of United States exports, but this represents only about eight percent of its total imports. Three of the barriers contributing to…

  9. Energy market of the European union: common or segmented?

    SciTech Connect

    Nowak, Bartlomiej

    2010-12-15

    The European energy market operates on the premise of open and competitive markets among its 27 member states. But the gas and electricity market dynamics and levels of competitiveness vary enormously across the EU 27. Among the issues are unequal implementation of electricity and gas directives, a lack of independent energy regulators, the absence of proper and full unbundling, and discriminatory third-party access to the infrastructure. (author)

  10. The Integration Role of European Defense Procurement in Achieving a More Competitive and Stronger European Defense Equipment Market

    DTIC Science & Technology

    2015-06-01

    DEFENSE PROCUREMENT IN ACHIEVING A MORE COMPETITIVE AND STRONGER EUROPEAN DEFENSE EQUIPMENT MARKET by Kiril O. Angelov June 2015 Thesis Advisor...COMPETITIVE AND STRONGER EUROPEAN DEFENSE EQUIPMENT MARKET 5. FUNDING NUMBERS 6. AUTHOR(S) Kiril O. Angelov 7. PERFORMING ORGANIZATION NAME(S) AND...creation of a strong and competitive European defense equipment market out of the 28 fragmented markets of the EU member states remains an important

  11. Investing in European market real property through reits

    NASA Astrophysics Data System (ADS)

    Adamuscin, A.

    2010-03-01

    For institutional and private investors, investing in real estate represents an attractive form of the consignment of their money. Real estate provides a regular source of income in the form of the rent from or interest on the credit provided. At the same time, real estate is a good investment instrument, because it provides diversified contributions and security against inflation for investors. In their efforts to diversify risk, investors are expressing growing interest in investing in the whole European Union. The success of Real Estate Investment Trusts (REITs) in the U.S. also opened the door for investing in this market for small investors, which is the reason for the development of this type of investment company in the European arena. One problem concerning the development of European real estate investment funds is the unsolved issue of the harmonization of the legislation and regulatory safety measures, which would enable the creation of a common market for new investment products in Europe.

  12. European drug market entries 2015 with new mechanisms of action.

    PubMed

    van den Heuvel, Titus W P; Cohen, Adam F; Rissmann, Robert

    2016-10-01

    In this article, we consider the new drugs approved for the European market in 2015. We present a summary of the new mechanisms of action introduced and highlight three new mechanisms of action with a potentially high future impact: PCSK9 inhibition (alirocumab (Praluent®) and evolocumab (Repatha®)) for hypercholesterolaemia, neprilysin inhibition (sacubitril in combination with valsartan (Entresto®)) for heart failure, and interleukin-5 inhibition (mepolizumab (Nucala®)) for asthma.

  13. Dossier for marketing authorization in the European union.

    PubMed

    Todić, Maida

    2003-03-01

    Extensive and complete documentation must be presented for marketing authorization of a medicinal product in the EU. Presented documentation should prove quality, safety and efficacy of the medicinal product. It is ensured that the applicant supplies the authorities with complete information. The legislation in Federation of Bosnia and Herzegovina has also taken more steps towards those European directions. The presentation and content of the dossier in the European Union has been redefined. The "old" EU format will be replaced with the Common Technical Document (EU CTD format) agreed in 2000, within the International Conference on Harmonization framework. These two formats are intended to coexist during the transition period until July 2003. The CTD is an internationally agreed upon format for the preparation of a well structured presentation for applications to be submitted to regulatory authorities in the three ICH regions of Europe, US and Japan.

  14. European market developments in prebiotic- and probiotic-containing foodstuffs.

    PubMed

    Young, J

    1998-10-01

    A growing number of food manufacturers in western Europe are beginning to explore the commercial opportunities for foodstuffs containing health-promoting microbial food supplements (probiotics) and health-promoting non-digestible food ingredients (prebiotics). A prebiotic is considered to affect the host beneficially by selectively stimulating the growth and/or activity of one or a limited number of naturally present or introduced bacterial species in the colon, also leading to a claimed improvement in host health. Increasingly, probiotics and prebiotics are used in combination, this being termed a synbiotic (Gibson & Roberfroid, 1995). Throughout European history, fermented milk products in particular have been considered beneficial to health, but only in recent years has there been scientific support for these beliefs. Issues considered important to the continuing development of this growing market are proof of safety, proof of efficacy, consumer education, market positioning, price and appropriate health claims strategies. Until recently, much of the innovation in the use of probiotics and prebiotics has been in the dairy cabinet, with an ever-growing number and range of 'health-promoting' yoghurts and yoghurt-type fermented milk being made available to the European consumer, a market which is currently estimated to be worth in excess of $US2 billion per annum (Hilliam et al. 1997). However, prebiotics are beginning to find increasing application outside the dairy sector, particularly in baked goods. A key driver behind the broadening application of prebiotics has been the pro-active stance taken by key prebiotic suppliers such as Beghin-Say, Orafti and Cosucra. To date, market activity in probiotic- and prebiotic-containing foods has centred around three health propositions, namely improving general gut health, lowering blood cholesterol and improving the body's natural defences.

  15. System architecture and market aspects of an European Land Mobile Satellite System via EMS

    NASA Astrophysics Data System (ADS)

    Ananasso, F.; Mistretta, I.

    1992-03-01

    The paper describes an implementation scenario of a Land Mobile Satellite System via the EMS (European Mobile System) payload embarked on Italsat F-2. Some emphasis is given on market issues aiming at singling out business niches of Land Mobile Satellite Services (LMSS) in Europe. Other crucial issues exist such as: the alternate/competitive systems, the problems of interworking with other existing and/or planned systems, the definition of network architecture that better fits the user requirements, the marketing strategy and, last but not least, the financial evaluation of the project. The paper, on the basis of a study performed by Telespazio on behalf of ESA, discusses some of these issues with emphasis on competitive market aspects.

  16. Wood products trade and foreign markets: european market profile issue, July 1994. Foreign agriculture circular

    SciTech Connect

    Not Available

    1994-07-01

    ;Contents: Trade Highlights; Top Five Markets for U.S. Wood Products; Status of USDA/CCC Export Credit Guarantees for Wood Products; Profiles for Wood Products; European Union; Austria; Belgium-Luxembourg; Denmark; Commodity/Country Trade Tables; Corrigendum; Wood Products Trade Account, 1st Quarter 1994; U.S. Exports, for 1989 - 1st Quarter 1994; Value of Wood Products, by Country; Value of Wood Products, by Commodity.

  17. The Role of Marketization in the Europeanization of Defense Industry Policy

    ERIC Educational Resources Information Center

    Britz, Malena

    2010-01-01

    European integration has increased to encompass security-related policies. One such policy is defense industry policy, which traditionally has been a national concern rooted in defense and security policy. Efforts have been made since the 1990s to create a European defense industry market. However, there have been different ideas of how this goal…

  18. Towards a European Academic Labour Market?: Some Lessons Drawn from Empirical Studies on Academic Mobility

    ERIC Educational Resources Information Center

    Musselin, Christine

    2004-01-01

    In Europe, academic mobility has a long tradition which began with the birth of the European universities in the middle ages. Recently, European policies were strongly oriented towards the promotion of student and academic mobility and the creation of research networks and projects within Europe. Nevertheless, academic labour markets in Europe…

  19. Time-varying long term memory in the European Union stock markets

    NASA Astrophysics Data System (ADS)

    Sensoy, Ahmet; Tabak, Benjamin M.

    2015-10-01

    This paper proposes a new efficiency index to model time-varying inefficiency in stock markets. We focus on European stock markets and show that they have different degrees of time-varying efficiency. We observe that the 2008 global financial crisis has an adverse effect on almost all EU stock markets. However, the Eurozone sovereign debt crisis has a significant adverse effect only on the markets in France, Spain and Greece. For the late members, joining EU does not have a uniform effect on stock market efficiency. Our results have important implications for policy makers, investors, risk managers and academics.

  20. Agent-specific impact of single trades in financial markets

    NASA Astrophysics Data System (ADS)

    Bladon, Alex J.; Moro, Esteban; Galla, Tobias

    2012-03-01

    We present an analysis of the price impact associated with single trades effected by different financial firms. Using data from the Spanish Stock Market, we find a high degree of heterogeneity across different market members, both in the instantaneous impact functions and in the time-dependent market response to trades by individual members. This heterogeneity is statistically incompatible with the existence of market-wide universal impact dynamics that apply uniformly to all trades and suggest that, rather, market dynamics emerge from the complex interaction of different behaviors of market participants. Several possible reasons for this are discussed, along with potential extensions one may consider to increase the range of applicability of existing models of market impact.

  1. The European Market for Animal-Friendly Products in a Societal Context

    PubMed Central

    Ingenbleek, Paul T. M.; Harvey, David; Ilieski, Vlatko; Immink, Victor M.; de Roest, Kees; Schmid, Otto

    2013-01-01

    Simple Summary This article takes a future focus on the direction in which social forces develop the market for animal-friendly products in Europe. Although many stakeholders believe that the market is the most viable direction to improve farm animal welfare, economic productivity of the chain remains an issue that on a fundamental level conflicts with the objective to improve animal welfare. The European market for animal-friendly products is still largely fragmented and the differences between European countries are considerable. A more animal-friendly future that is achieved through the market will therefore need substantial policy attention from stakeholders in society. Abstract This article takes a future focus on the direction in which social forces develop the market for animal-friendly products in Europe. On the basis of qualitative data gathered in the context of the European EconWelfare project, the differences across eight European countries are studied. The findings suggest that, given international trade barriers that prevent an improvement of animal welfare through legislation, many stakeholders believe that the market is the most viable direction to improve farm animal welfare. Economic productivity of the chain remains, however, an issue that on a fundamental level conflicts with the objective to improve animal welfare. With the help of a deeper conceptual understanding of willingness to pay for animal welfare, the paper finds that the European market for animal-friendly products is still largely fragmented and that the differences between European countries are considerable. A more animal-friendly future that is achieved through the market will therefore need substantial policy attention from stakeholders in society. PMID:26479535

  2. The Media, Marketing, and Single Sex Schooling

    ERIC Educational Resources Information Center

    Mills, Martin

    2004-01-01

    The Australian media's interest in education, as in many Anglophone countries, is frequently dominated by concerns about boys in schools. In 2002, in a country region of the Australian State of Queensland, this concern was evident in a debate on the merits of single sex schooling that took place in a small local newspaper. The debate was fuelled…

  3. European Databanks on the March and The U.S.A. as a Potential Market for British Information Products.

    ERIC Educational Resources Information Center

    Provenzano, Dominic; And Others

    1987-01-01

    Detailed profiles and comparisons of European databanks being marketed in the United States include marketing strategies, subject content, number and types of databases offered, cost information, value added services, and more. Users' views of the viability, ease of use, and strengths and weaknesses of European databases are presented. (CLB)

  4. The European Market for Animal-Friendly Products in a Societal Context.

    PubMed

    Ingenbleek, Paul T M; Harvey, David; Ilieski, Vlatko; Immink, Victor M; de Roest, Kees; Schmid, Otto

    2013-08-14

    This article takes a future focus on the direction in which social forces develop the market for animal-friendly products in Europe. On the basis of qualitative data gathered in the context of the European EconWelfare project, the differences across eight European countries are studied. The findings suggest that, given international trade barriers that prevent an improvement of animal welfare through legislation, many stakeholders believe that the market is the most viable direction to improve farm animal welfare. Economic productivity of the chain remains, however, an issue that on a fundamental level conflicts with the objective to improve animal welfare. With the help of a deeper conceptual understanding of willingness to pay for animal welfare, the paper finds that the European market for animal-friendly products is still largely fragmented and that the differences between European countries are considerable. A more animal-friendly future that is achieved through the market will therefore need substantial policy attention from stakeholders in society.

  5. Teaching Media and Methods in Marketing: European and North American Universities

    ERIC Educational Resources Information Center

    Vila, Natalia; Kuster, Ines

    2009-01-01

    This article aims to examine the most widely used teaching media and methods in university education. To achieve this objective, international research has been carried out among 135 marketing teachers from North American and European universities. The study shows that North American teachers use more traditional media and participatory methods…

  6. The Development of Public Relations To Meet the New European Market.

    ERIC Educational Resources Information Center

    Neff, Bonita Dostal; Brown, Robert

    The development of public relations follows when economic development and democracy thrive. EC 1992, with its plans for the European Common Market Community, is a public relations opportunity for U.S. public relations firms. In a survey of 31 firms, 6 owned or were owned by networks, 17 had membership in a network, 8 had no public relations…

  7. The Benefit of Educational Inclusiveness for Early School Leavers in the European Labour Market

    ERIC Educational Resources Information Center

    van Alphen, Stan

    2012-01-01

    Previous research suggests that the ongoing educational expansion is a negative development for early school leavers (ESLrs) in the European labour market, since it increases the level and educational attainment of their competition, and in the worst case creates credential inflation. Findings from the 2005 cross-sectional EU-SILC data show,…

  8. Development of advanced concepts for DIR-MCFC cogeneration applications in the European Market

    SciTech Connect

    Kortbeek, P.J.; Ottervanger, R.G.; Dicks, A.L.

    1996-12-31

    Early 1996 a three year (1996 - 1998) joint European project was launched under the name {open_quote}Advanced DIR-MCFC Development{close_quote}, aiming at the development of Direct Internal Reforming (DIR) Molten Carbonate Fuel Cell (MCFC) systems for cogeneration applications for the European market. In this project participate: Brandstofcel Nederland BV (BCN), British Gas pic (BG), Gaz de France (GDF), Netherlands Energy Research foundation (ECN), Stork, Royal Schelde and Sydkraft AB. The European Fuel Cell User Group (EFCUG) supports the project as an advisory board. Whereas the US and Japanese programmes are aimed at large-scale demonstrations of the MCFC technology, this project focusses on the development of concepts and technology, required for MCFC systems that will be competative on the cogeneration market. The project partners provide the essential expertise: from end-user, system engineering, stack development up to fundamental material research.

  9. Evidence of multifractality from emerging European stock markets.

    PubMed

    Caraiani, Petre

    2012-01-01

    We test for the presence of multifractality in the daily returns of the three most important stock market indices from Central and Eastern Europe, Czech PX, Hungarian BUX and Polish WIG using the Empirical Mode Decomposition based Multifractal Detrended Fluctuation Analysis. We found that the global Hurst coefficient varies with the q coefficient and that there is multifractality evidenced through the multifractal spectrum. The exercise is replicated for the sample around the high volatility period corresponding to the last global financial crisis. Although no direct link has been found between the crisis and the multifractal spectrum, the crisis was found to influence the overall shape as quantified through the norm of the multifractal spectrum.

  10. Evidence of Multifractality from Emerging European Stock Markets

    PubMed Central

    Caraiani, Petre

    2012-01-01

    We test for the presence of multifractality in the daily returns of the three most important stock market indices from Central and Eastern Europe, Czech PX, Hungarian BUX and Polish WIG using the Empirical Mode Decomposition based Multifractal Detrended Fluctuation Analysis. We found that the global Hurst coefficient varies with the q coefficient and that there is multifractality evidenced through the multifractal spectrum. The exercise is replicated for the sample around the high volatility period corresponding to the last global financial crisis. Although no direct link has been found between the crisis and the multifractal spectrum, the crisis was found to influence the overall shape as quantified through the norm of the multifractal spectrum. PMID:22815792

  11. Single-Sex Schooling and Labour Market Outcomes

    ERIC Educational Resources Information Center

    Sullivan, Alice; Joshi, Heather; Leonard, Diana

    2011-01-01

    One quarter of the 1958 British Birth cohort attended single-sex secondary schools. This paper asks whether sex-segregated schooling had any impact on the experience of gender differences in the labour market in mid-life. We examine outcomes at age 42, allowing for socio-economic origins and abilities measured in childhood. We find no net impact…

  12. [Marketing of medicinal products in the European Community. The Mutual Recognition and Decentralised Procedures].

    PubMed

    Bachmann, Peter

    2008-07-01

    The Mutual Recognition Procedure (MRP) and the Decentralised Procedure (DCP), which were first established in late 2005, can be regarded as the backbone for marketing authorisation of medicinal products in the European Community (EC) and the European Economic Area (EEA). Both procedures are compared and advantages and disadvantages are discussed. However, the focus is more related to current developments than the detailed comparison of both procedures. The role of the Coordination Group for Mutual Recognition and Decentralised Procedures-Human (CMD(h)) and the decision making process in relation to the MRP and DCP is also discussed.

  13. The impact of a deregulated European electricity market on Volvo in Sweden

    SciTech Connect

    Dag, S.

    1998-07-01

    The member countries within the European Union (EU) have agreed to open all national electricity markets for competition, starting January 1, 1999. The electricity market in Sweden is deregulated since January 1, 1996. The deregulation of the electricity markets will gradually shift the electricity price levels in different countries towards an equal price level, which will most likely be close to the levels on the Continental Europe. A deregulated European electricity market may change the competition situation for Swedish industries dramatically. The capacity in electric generation with low operating costs in Sweden has led to very low electricity prices and high usage level compared to other EU countries. The consumption level of electric energy per capita is nearly three times higher in Sweden than the average per capita EU usage. The high level of electricity consumption is typical also of industrial customers in Sweden. Studies of Volvo Car Corporation have shown that the Volvo car plant in Torslanda, Sweden utilizes substantially more electric energy per manufactured car than the Volvo car plant in Gent, Belgium. A method is developed to transform the Torslanda plant from a low energy efficiency state to a higher energy efficiency state by modeling. The method is based on the Life Cycle Cost (LCC) concept and includes optimization models of the two plants with mixed integer linear programming (MILP).

  14. Probiotic formulations and applications, the current probiotics market, and changes in the marketplace: a European perspective.

    PubMed

    Saxelin, Maija

    2008-02-01

    Europe is a multicultural continent where the consumption of fermented milks has traditionally been high in several countries. Thus, it is no wonder that the market for fermented dairy products with probiotic bacteria has been successful. The market for food applications of probiotics is clearly larger than that for probiotics sold in capsules, sachets, and other pharmaceutical forms. Yogurt-type drinks are the fastest-growing product category, but the diversity of probiotic food applications is not limited to milk-based products. Probiotic fruit juices, berry soups, and soy- and cereal-based fermented products are also sold. Some probiotic strains that are successful in Europe are marketed globally, but there is also a variety of local probiotic strains that are key players in their limited markets. The health messages of probiotic products have focused mainly on general well-being and support of gastrointestinal microbiota. However, because of newly accepted regulation from the European Union regarding health claims, such claims will be evaluated officially, which may substantially change their content. However, more-specific product claims may also appear on the market. This article describes trends and phenomena in mainly the food sector, which covers the most-successful probiotic applications, but food supplements are also discussed.

  15. Post-marketing surveillance and vigilance for medical devices: the European approach.

    PubMed

    Randall, H

    2001-01-01

    The extent to which the medical device manufacturers are responsible for actively monitoring the performance of their products after they have successfully passed the rigorous pre-market approval process has always been a matter of diverse opinion. Within Europe, the law is unhelpfully vague on this point. While there are some comparatively clear obligations for reporting incidents to the authorities (known as the 'vigilance system'), little detail is given on how diligently the manufacturer should try to find out about such incidents. In the early stages of the European Community Directives covering medical devices, there was much emphasis upon formulating guidance to help interpret the vigilance reporting requirements. It is, however, only recently that attention has turned to attempting to clarify what is expected from post-marketing surveillance (PMS) in its broader sense. This article discuses both the vigilance and PMS processes and outlines the currently available European, and particularly UK, guidance documents which are aimed at promoting a more level playing field across industry where these activities are concerned. In particular, it explains the principle differences between vigilance and post-marketing surveillance: the former being the reporting of adverse incidents by manufacturers to the regulatory authorities and their subsequent sharing of key incident data between each other; the latter being the process by which information on overall devise performance is captured, analysed and acted upon. Nevertheless, it is still a struggle to gain widespread appreciation that these two activities are not in fact one and the same.

  16. Florbetapir (18F) for brain amyloid positron emission tomography: highlights on the European marketing approval.

    PubMed

    Cortes-Blanco, Anabel; Prieto-Yerro, Concha; Martinez-Lazaro, Raul; Zamora, Javier; Jiménez-Huete, Adolfo; Haberkamp, Marion; Pohly, Johannes; Enzmann, Harald; Zinserling, Jörg; Strassmann, Valerie; Broich, Karl

    2014-10-01

    Florbetapir (18F) for brain amyloid positron emission tomography (PET) imaging has been recently approved in Europe to estimate β-amyloid neuritic plaque density in the brain when the subject is still alive. Such density is one of the key issues for the definitive diagnosis of Alzheimer's disease (AD) at autopsy. This capability of florbetapir (18F) is regarded as a significant improvement in the diagnostic procedures for adult patients with cognitive impairment who are being evaluated for AD and other causes of cognitive impairment. The current paper highlights the specific characteristics of the European marketing authorization of florbetapir (18F).

  17. Statistical regularities of Carbon emission trading market: Evidence from European Union allowances

    NASA Astrophysics Data System (ADS)

    Zheng, Zeyu; Xiao, Rui; Shi, Haibo; Li, Guihong; Zhou, Xiaofeng

    2015-05-01

    As an emerging financial market, the trading value of carbon emission trading market has definitely increased. In recent years, the carbon emission allowances have already become a way of investment. They are bought and sold not only by carbon emitters but also by investors. In this paper, we analyzed the price fluctuations of the European Union allowances (EUA) futures in European Climate Exchange (ECX) market from 2007 to 2011. The symmetric and power-law probability density function of return time series was displayed. We found that there are only short-range correlations in price changes (return), while long-range correlations in the absolute of price changes (volatility). Further, detrended fluctuation analysis (DFA) approach was applied with focus on long-range autocorrelations and Hurst exponent. We observed long-range power-law autocorrelations in the volatility that quantify risk, and found that they decay much more slowly than the autocorrelation of return time series. Our analysis also showed that the significant cross correlations exist between return time series of EUA and many other returns. These cross correlations exist in a wide range of fields, including stock markets, energy concerned commodities futures, and financial futures. The significant cross-correlations between energy concerned futures and EUA indicate the physical relationship between carbon emission and energy production process. Additionally, the cross-correlations between financial futures and EUA indicate that the speculation behavior may become an important factor that can affect the price of EUA. Finally we modeled the long-range volatility time series of EUA with a particular version of the GARCH process, and the result also suggests long-range volatility autocorrelations.

  18. Export competitiveness of dairy products on global markets: the case of the European Union countries.

    PubMed

    Bojnec, Š; Fertő, I

    2014-10-01

    This paper analyzed the export competitiveness of dairy products of the European Union (EU) countries (EU-27) on intra-EU, extra-EU, and global markets, using the revealed comparative advantage index over the 2000-2011 period. The results indicated that about half of the EU-27 countries have had competitive exports in a certain segment of dairy products. The results differed by level of milk processing and for intra-EU and extra-EU markets, and did so over the analyzed years. Belgium, Denmark, France, Ireland, and the Netherlands are old EU-15 countries with competitive dairy exports (from the lowest to the highest according to the level of milk processing). The majority of the new EU-12 countries have faced difficulties in maintaining their level of export competitiveness, at least for some dairy products and market segments. The more competitive EU-12 countries in dairy exports were the Baltic States (Estonia, Latvia, and Lithuania) and Poland. The duration of export competitiveness differed across the dairy groups of products according to the level of milk processing, indicating the importance of dairy chain product differentiation for export competitiveness and specialization. The export competitiveness of the higher level of processed milk products for final consumption can be significant for export dairy chain competitiveness on global markets.

  19. Changes in European legislation make it timely to introduce a transparent market surveillance system for cosmetics.

    PubMed

    Lodén, Marie; Ungerth, Louise; Serup, Jørgen

    2007-01-01

    Marketing of cosmetics often makes strong claims linked to active ingredients. This is especially so for anti-ageing products, where the presentation and content of "active" ingredients may create new difficulties in their classification as cosmetics or medicinal products. A recent change in European legislation classifies a product as medicinal by virtue of its "function", in addition to the previous definition of "presentation" (i.e. marketing linked to diseases). Thus, formulations that also restore, correct or modify physiological functions by exerting a pharmacological, immunological or metabolic action should henceforth be covered by the Medicinal Products Directive. A cosmetic product must be suitable for its purpose and should not lead to adverse reactions that are disproportional in relation to its intended effect. However, the forthcoming ban on animal testing of cosmetic ingredients and the new European regulation, REACH (Registration, Evaluation and Authorisation of Chemicals), which aims to ensure a high level of chemical safety to protect human health and the environment, will probably have limited impact on the safety assessment of cosmetics. In order to enable consumers to make informed purchasing decisions, greater transparency in the process of assessing the performance of cosmetics is needed. Introduction of a more transparent system, enabling consumers and professionals to examine the scientific evidence for the claimed effect and the safety assessment of cosmetics, is therefore timely. Lack of transparency increases the risk of consumers wasting money on cosmetics that do not deliver the desired effects. This may jeopardize public trust in the cosmetic industry.

  20. Market access of cancer drugs in European countries: improving resource allocation.

    PubMed

    Pauwels, Kim; Huys, Isabelle; Casteels, Minne; De Nys, Katelijne; Simoens, Steven

    2014-06-01

    Public health systems need to make well-founded choices in order to distribute their scarce resources in the most efficient way. Given the number of cancer patients, public/private investments in oncology research, the growing number of new anti-cancer agents and consequent budget impact of cancer care, market access of cancer drugs has become delicate over the last decade. Furthermore, decision makers are challenged by ethical objections and endeavour to provide fair and equal access to treatments for cancer patients. The aim of this study is to generate an overview of market access procedures for cancer drugs in eight European countries and formulate advice for improvement of resource allocation. Results are obtained through a literature review and a qualitative questionnaire and validated by experts with proven knowledge about procedures for price setting and reimbursement of drugs. Diverse measures are applied in the studied countries to optimize reimbursement of cancer drugs such as adjusted cost-effectiveness threshold, regulations for off-label use and new market access agreements. Additionally, innovative cancer drugs are excluded from explicit cost control measures such as payback of budget excess by pharmaceutical companies and lump-sum payments per diagnostic related groups (DRG) in the hospital. The results suggest that cancer is prioritized above other disease areas. Further research is necessary to address the question if society attaches higher value to cancer drugs than to treatments for other diseases.

  1. Granting marketing authorisation for medicines in South East European countries: the point of view of the authority.

    PubMed

    Tomić, Sinisa; Sucić, Anita Filipović; Martinac, Adrijana Ilić

    2010-01-01

    European legislation for medicines places the emphasis on an assessment of quality, safety and efficacy during the procedure for the granting of marketing authorisations for medicines, in order to protect patient health. The integrated European regulatory system involves the participation of a network of experts from the agencies of the member states that takes part in the European procedures for the authorisation of medicines. On the way to full membership in the EU, candidate countries and potential candidates have to transpose and implement the European directives for medicinal products; they must also strengthen their scientific and administrative capacities. Croatia acquired good experience in implementing the simplified marketing authorisation procedure for medicines authorised in the EU pursuant to the New Collaboration Agreement between Drug Regulatory Authorities in Central and East European Countries (nCADREAC), which helps it to exchange information and prepare for the implementation of European procedures. However, there are still some provisions to transpose before actual full membership, and also dossier upgrading, in which the marketing authorisation holder has to harmonise its documentation about a medicinal product with the requirements of the directives, if a product already on the market was not previously approved in line with current European legislation. Collaboration with the European Medicines Agency (EMA) through an Instrument for Pre-Accession (IPA) provides candidate countries and potential candidates the opportunity for education and training in some regulatory activities as well as the participation of their representatives as observers in some EMA committees and working groups. Some characteristics of the national regulatory frameworks of the countries of South East Europe in their efforts to achieve harmonisation with EU legislation are presented in this paper.

  2. Overcoming Barriers to the Market Access of Biosimilars in the European Union: The Case of Biosimilar Monoclonal Antibodies

    PubMed Central

    Moorkens, Evelien; Jonker-Exler, Clara; Huys, Isabelle; Declerck, Paul; Simoens, Steven; Vulto, Arnold G.

    2016-01-01

    Background: In 2014, six of the top ten blockbuster medicines were monoclonal antibodies. This multibillion-dollar market with expiring patents is the main driver for the development of biosimilar mAbs. With the ever-increasing cost of healthcare and the economic pressure to reduce or sustain healthcare expenses, biosimilars could be instrumental in reducing costs for medication and increasing patient access to treatment. Objectives: The aim of this study is to identify and describe the barriers to market access of biosimilar mAbs in the European Union and to analyze how these barriers could be overcome. Methods: A narrative literature review was carried out using the databases PubMed, Embase, and EconLit. Studies were published in English or Dutch. Additionally, the reference list of the articles was checked for relevant studies. Articles and conference papers known to the authors were included as well. Articles were also identified by searching on the website of the Generics and Biosimilars Initiative (GaBI) journal. Results: Six barriers were identified based on available literature: The manufacturing process, the regulatory process, intellectual property rights, lack of incentive, the impossibility of substitution, and the innovator's reach. These six barriers are presented as a possible framework to study the market access of biosimilar mAbs. Based on the literature search, recommendations can be made to overcome these barriers: (i) invest initially in advanced production processes with the help of single-use technology, experience or outsourcing (ii) gain experience with the regulatory process and establish alignment between stakeholders (iii) limit patent litigation, eliminate evergreening benefits, build out further the unitary patent and unified patent litigation system within the EU (iv) create demand-side policies, disseminate objective information (v) change attitude toward biosimilar switching/substitution, starting with physician, and patient

  3. [Descriptive analysis of the various mammary implants available on European market in 2005].

    PubMed

    Desouches, C; Aharoni, C; Magalon, G

    2005-10-01

    Laboratories propose a large variety of mammary implants, in which the multiplicity makes it difficult for the surgeons to choose. The objective of this work was to analyze the various features of the implants proposed by manufacturers, in particular the characteristics of the shell, the specificities of the filling, and the morphology of the implants. Nine laboratories sell ten brands of mammary implants on the European market. The laboratories are: Arion, Eurosilicone, Inamed Aesthetics, Mentor, Nagor, Perouse Plastie, Poly Implants Protheses, Polytech Silimed and Sebbin. All laboratories propose smooth or textured surfaces on the shell. Only one laboratory uses a surface covered by micropolyurethane foam. The fillings consist of a saline solution or a silicone gel. One laboratory provides a filling with hydrogel containing carboxymethylcellulose. The forms suggested are round or anatomical. The various models propose a variation on the projection for the round implants and a variation on the height for the anatomical implants. Analysis of the different catalogues makes it possible to underline the lack of precision in the terms of usage, in particular for the description of the form and the texture. It is unfortunate to have very little technical information and no clinical or biological information imposed by the European standard EN 12180. This prevents the surgeon from making his choice according to the real quality of the implants.

  4. A Comparative Analysis of Graduate Employment Prospects in European Labour Markets: A Study of Graduate Recruitment in Four Countries

    ERIC Educational Resources Information Center

    Branine, Mohamed; Avramenko, Alex

    2015-01-01

    The aim of this paper is to provide a comparative analysis of higher education and the graduate labour markets in selected European countries (France, Germany, Spain and United Kingdom) in the context of the expectations of graduates and prospective employers, and respective recruitment and selection practices. Expectations of graduating students…

  5. Observations on Three Endpoint Properties and Their Relationship to Regulatory Outcomes of European Oncology Marketing Applications

    PubMed Central

    Stolk, Pieter; McAuslane, James Neil; Schellens, Jan; Breckenridge, Alasdair M.; Leufkens, Hubert

    2015-01-01

    Background. Guidance and exploratory evidence indicate that the type of endpoints and the magnitude of their outcome can define a therapy’s clinical activity; however, little empirical evidence relates specific endpoint properties with regulatory outcomes. Materials and Methods. We explored the relationship of 3 endpoint properties to regulatory outcomes by assessing 50 oncology marketing authorization applications (MAAs; reviewed from 2009 to 2013). Results. Overall, 16 (32%) had a negative outcome. The most commonly used hard endpoints were overall survival (OS) and the duration of response or stable disease. OS was a component of 91% approved and 63% failed MAAs. The most commonly used surrogate endpoints were progression-free survival (PFS), response rate, and health-related quality of life assessments. There was no difference (p = .3801) between the approved and failed MAA cohorts in the proportion of hard endpoints used. A mean of slightly more than four surrogate endpoints were used per approved MAA compared with slightly more than two for failed MAAs. Longer OS and PFS duration outcomes were generally associated with approvals, often when not statistically significant. The approved cohort was associated with a preponderance of statistically significant (p < .05) improvements in primary endpoints (p < .0001 difference between the approved and failed groups). Conclusion. Three key endpoint properties (type of endpoint [hard/surrogate], magnitude of an endpoint outcome, and its statistical significance) are consistent with the European Medicines Agency guidance and, notwithstanding the contribution of unique disease-specific circumstances, are associated with a predictable positive outcome for oncology MAAs. Implications for Practice: Regulatory decisions made by the European Medicines Agency determine which new medicines will be available to European prescribers and for which therapeutic indications. Regulatory success or failure can be influenced by many

  6. Interdependence between Greece and other European stock markets: A comparison of wavelet and VMD copula, and the portfolio implications

    NASA Astrophysics Data System (ADS)

    Shahzad, Syed Jawad Hussain; Kumar, Ronald Ravinesh; Ali, Sajid; Ameer, Saba

    2016-09-01

    The interdependence of Greece and other European stock markets and the subsequent portfolio implications are examined in wavelet and variational mode decomposition domain. In applying the decomposition techniques, we analyze the structural properties of data and distinguish between short and long term dynamics of stock market returns. First, the GARCH-type models are fitted to obtain the standardized residuals. Next, different copula functions are evaluated, and based on the conventional information criteria and time varying parameter, Joe-Clayton copula is chosen to model the tail dependence between the stock markets. The short-run lower tail dependence time paths show a sudden increase in comovement during the global financial crises. The results of the long-run dependence suggest that European stock markets have higher interdependence with Greece stock market. Individual country's Value at Risk (VaR) separates the countries into two distinct groups. Finally, the two-asset portfolio VaR measures provide potential markets for Greece stock market investment diversification.

  7. Implications of 1992 for European Telecommunications.

    ERIC Educational Resources Information Center

    Muller, Jurgen

    This paper analyzes the effect of the unified single market of 1992 on European telecommunications. The major policy aspects of the European Economic Commission's Green Paper on "The Development of the Common Market for Telecommunications Services and Equipment" are highlighted, and the effects of these policies in the equipment market…

  8. Modeling Flood Insurance Penetration in the European Non-Life Market: An Overview

    NASA Astrophysics Data System (ADS)

    Mohan, P.; Thomson, M.-K.; Das, A.

    2012-04-01

    Non-life property insurance plays a significant role in assessing and managing economic risk. Understanding the exposure, or property at risk, helps insurers and reinsurers to better categorize and manage their portfolios. However, the nature of the flood peril, in particular adverse selection, has led to a complex system of different insurance covers and policies across Europe owing to its public and private distinctions based on premiums provided as ex ante or ex post, socio-economic characterization and various compensation schemes. To model this significant level of complexity within the European flood insurance market requires not only extensive data research, close understanding of insurance companies and associations as well as historic flood events, but also careful evaluation of the flood hazard in terms of return periods and flood extents, and the economic/ financial background of the geographies involved. This abstract explores different approaches for modeling the flood insurance penetration rates in Europe depending on the information available and complexity involved. For countries which have either a regulated market with mandatory or high penetration rate, as for example found in the UK, France and Switzerland, or indeed countries with negligible insurance cover such as Luxembourg, assumptions about the penetration rates can be made at country level. However, in countries with a private insurance market, the picture becomes inherently more complex. For example in both Austria and Germany, flood insurance is generally restricted, associated with high costs to the insured or not available at all in high risk areas. In order to better manage flood risk, the Austria and German government agencies produced the risk classification systems HORA and ZÜRS, respectively, which categorize risk into four risk zones based on the exceedance probability of a flood occurrence. Except for regions that have preserved mandatory flood inclusion from past policies

  9. [European Marketing Authorisation: a long process. Experiences of small biotech companies with the ATMP regulation].

    PubMed

    Buljovčić, Z

    2011-07-01

    On 30 December 2008, the Regulation (EC) 1394/2007 on advanced therapy medicinal products (ATMPs) entered into force. Herewith the first EU-wide regulatory framework for ATMPs was established. It requires a central marketing authorisation application to the EMA (European Medicinal Agency). This new framework especially changes the code of regulatory practice for tissue engineered products (TEPs), as no registration procedure had been previously required for autologous TEPs. This also meant that no clinical proof of efficacy achieved by a pivotal clinical trial was necessary. Difficulties and their background as well as the vast requirements for product development that have to be addressed by small companies within a very short time frame are presented. Hereby, it is obvious that regulatory experience which is required to identify and implement the resulting implications was not in place yet and still had to be established. The lack of regulatory experience also resulted in difficulties with scientific advice preparation, expectations toward regulatory agencies, consultants, and transformation of regulatory requirements. Addressing the regulatory requirements within the transition period is even more difficult for entrepreneurs with products which are assigned for indications resulting in complex challenges to the trial design. Due to the enormous time pressure to generate data and due to the implied financial pressure, different adaptation strategies are evolving. In Germany the "hospital exemption" according to §4b AMG (German Medicinal Products Law) is of major importance. A reorientation toward acellular products and a slow down in development of new ATMP products is expected.

  10. The Impact of New Execution Venues on European Equity Markets' Liquidity - The Case of Chi-X

    NASA Astrophysics Data System (ADS)

    Chlistalla, Michael; Lutat, Marco

    With the Markets in Financial Instruments Directive in effect since November 2007, new trading venues have emerged in European equities trading, among them Chi-X. This paper analyzes the impact of this new market entrant on the home market as well as on consolidated liquidity of French blue chip equities, newly tradable on Chi-X. Our findings suggest that owing to this new competition the home market’s liquidity has enhanced. This is apparently due to the battle for order flow which results in narrower spreads and increased market depth. These results imply that overall liquidity in a virtually consolidated order book is in the French case higher than without the new competitor.

  11. Kinetic market models with single commodity having price fluctuations

    NASA Astrophysics Data System (ADS)

    Chatterjee, A.; Chakrabarti, B. K.

    2006-12-01

    We study here numerically the behavior of an ideal gas like model of markets having only one non-consumable commodity. We investigate the behavior of the steady-state distributions of money, commodity and total wealth, as the dynamics of trading or exchange of money and commodity proceeds, with local (in time) fluctuations in the price of the commodity. These distributions are studied in markets with agents having uniform and random saving factors. The self-organizing features in money distribution are similar to the cases without any commodity (or with consumable commodities), while the commodity distribution shows an exponential decay. The wealth distribution shows interesting behavior: gamma like distribution for uniform saving propensity and has the same power-law tail, as that of the money distribution, for a market with agents having random saving propensity.

  12. The impact of clustering of extreme European windstorm events on (re)insurance market portfolios

    NASA Astrophysics Data System (ADS)

    Mitchell-Wallace, Kirsten; Alvarez-Diaz, Teresa

    2010-05-01

    Traditionally the occurrence of windstorm loss events in Europe has been considered as independent. However, a number of significant losses close in space and time indicates that this assumption may need to be revised. Under particular atmospheric conditions multiple loss-causing cyclones can occur in succession, affecting similar geographic regions and, therefore, insurance markets. A notable example is of Lothar and Martin in France in December 1999. Although the existence of cyclone families is well-known by meteorologists, there has been limited research into occurrence of serial windstorms. However, climate modelling research is now providing the ability to explore the physical drivers of clustering, and to improve understanding of the hazard aspect of catastrophe modelling. While analytics tools, including catastrophe models, may incorporate assumptions regarding the influence of dependency through statistical means, the most recent research outputs provide a new strand of information with the potential to re-assess the probabilistic loss potential in light of clustering and to provide an additional view on probable maximum losses to windstorm-exposed portfolios across regions such as Northwest Europe. There is however, a need for the testing of these new techniques within operational (re)insurance applications, and this paper provide an overview of the most current clustering research, including the 2009 paper by Vitolo et. al., in relation to reinsurance risk modelling, and to assess the potential impact of such additional information on the overall risk assessment process. We examine the consequences of the serial clustering of extra-tropical cyclones demonstrated by Vitolo et al. (2009) from the perspective of a large European reinsurer, examining potential implications for: • Pricing • Accumulation And • Capital adequacy

  13. Adult Education and the Labour Market. European Society for Research on the Education of Adults Seminar Proceedings (Ljubljana, Slovenia, October 10-12, 1993). First Edition.

    ERIC Educational Resources Information Center

    Klenovsek, Tanja Vilic, Ed.; Olesen, Henning Salling, Ed.

    This book contains papers, reports, and welcoming speeches from a seminar for European adult education researchers. The following are included: "Background and Thematic Outline for the ESREA (European Society for Research on the Education of Adults) Seminar on Research into Adult Education and the Labor Market" (Olesen); "Welcoming…

  14. Perspectives for imaging single protein molecules with the present design of the European XFEL

    PubMed Central

    Ayyer, Kartik; Geloni, Gianluca; Kocharyan, Vitali; Saldin, Evgeni; Serkez, Svitozar; Yefanov, Oleksandr; Zagorodnov, Igor

    2015-01-01

    The Single Particles, Clusters and Biomolecules & Serial Femtosecond Crystallography (SPB/SFX) instrument at the European XFEL is located behind the SASE1 undulator and aims to support imaging and structure determination of biological specimen between about 0.1 μm and 1 μm size. The instrument is designed to work at photon energies from 3 keV up to 16 keV. Here, we propose a cost-effective proof-of-principle experiment, aiming to demonstrate the actual feasibility of a single molecule diffraction experiment at the European XFEL. To this end, we assume self-seeding capabilities at SASE1 and we suggest to make use of the baseline European XFEL accelerator complex—with the addition of a slotted-foil setup—and of the SPB/SFX instrument. As a first step towards the realization of an actual experiment, we developed a complete package of computational tools for start-to-end simulations predicting its performance. Single biomolecule imaging capabilities at the European XFEL can be reached by exploiting special modes of operation of the accelerator complex and of the SASE1 undulator. The output peak power can be increased up to more than 1.5 TW, which allows to relax the requirements on the focusing efficiency of the optics and to reach the required fluence without changing the present design of the SPB/SFX instrument. Explicit simulations are presented using the 15-nm size RNA Polymerase II molecule as a case study. Noisy diffraction patterns were generated and they were processed to generate the 3D intensity distribution. We discuss requirements to the signal-to-background ratio needed to obtain a correct pattern orientation. When these are fulfilled, our results indicate that one can achieve diffraction without destruction with about 0.1 photons per Shannon pixel per shot at 4 Å resolution with 1013 photons in a 4 fs pulse at 4 keV photon energy and in a 0.3 μm focus, corresponding to a fluence of 1014 photons/μm2. We assume negligible structured

  15. The influence of the European paediatric regulation on marketing authorisation of orphan drugs for children

    PubMed Central

    2014-01-01

    Background Drug development for rare diseases is challenging, especially when these orphan drugs (OD) are intended for children. In 2007 the EU Paediatric Drug Regulation was enacted to improve the development of high quality and ethically researched medicines for children through the establishment of Paediatric Investigation Plans (PIPs). The effect of the EU Paediatric Drug Regulation on the marketing authorisation (MA) of drugs for children with rare diseases was studied. Methods Data on all designated orphan drugs, their indication, MA, PIPs and indication group (adult or child) were obtained from the European Medicines Agency (EMA). The outcome and duration of the process from orphan drug designation (ODD) to MA, was compared, per indication, by age group. The effect of the Paediatric Drug Regulation, implemented in 2007, on the application process was assessed with survival analysis. Results Eighty-one orphan drugs obtained MA since 2000 and half are authorised for (a subgroup of) children; another 34 are currently undergoing further investigations in children through agreed PIPs. The Paediatric Drug Regulation did not significantly increase the number of ODDs with potential paediatric indications (58% before vs 64% after 2007 of ODDs, p = 0.1) and did not lead to more MAs for ODs with paediatric indications (60% vs 43%, p = 0.22). ODs authorised after 2007 had a longer time to MA than those authorised before 2007 (Hazard ratio (95% CI) 2.80 (1.84-4.28), p < 0.001); potential paediatric use did not influence the time to MA (Hazard ratio (95% CI) 1.14 (0.77-1.70), p = 0.52). Conclusions The EU Paediatric Drug Regulation had a minor impact on development and availability of ODs for children, was associated with a longer time to MA, but ensured the further paediatric development of drugs still off-label to children. The impact of the Paediatric Drug Regulation on research quantity and quality in children through PIPs is not yet clear. PMID

  16. Herbal medicinal products versus botanical-food supplements in the European market: state of art and perspectives.

    PubMed

    Bilia, Anna Rita

    2015-01-01

    Botanical products marketed in Europe are diverse, classified as herbal medicinal products, dietary supplements, cosmetics, foods and beverages depending on the relevant applicable legislation. Many factors are taken into account in the classification of a botanical product (e.g. intended use, labeling, preparations and dosages) according to how it is placed on the market. Herbal medicinal products (HMPs) can only be sold in pharmacies, under the supervision of a pharmacist, and are marketed after full or simplified registration procedures according to their classification, i.e. as over-the-counter drugs (OTC) available without special restrictions and prescription only medicine (POM), which must be prescribed by a licensed medical practitioner. The dietary supplement segment is also sold in the market in dose form (such as capsules, tablets, ampoules of liquids, drops etc) and represents 15-20% of the botanical market at the European level with high variability among each country (i.e. in Italy it reaches up to 80%). In many cases the distinction between medicinal products and food supplements has generated borderline botanical-sourced products, which generally produce confusion and mislead the consumers. As a consequence, there is an urgent need of consumer education and in addition to collect comprehensive data and make this database systematically available to herbalists, nutritionists and medical specialists for a proper classification and harmonization of the use of botanical ingredients, and, as consequence, a correct use of these products.

  17. European Regional Consultation on Management and Administration of Higher Education in a Market Economy. (Plovdiv, Bulgaria, November 20-23, 1990). Reports.

    ERIC Educational Resources Information Center

    Neave, G.; And Others

    This monograph presents four papers on the interaction of the market and higher education institutions in relation to the evolution of management and administrative patterns according to the requirements of new political and economic situations. In particular, the papers discuss the changes which a market ideology has brought to European higher…

  18. [NOTES and single port access: surgical or marketing revolution?].

    PubMed

    Allemann, P; Schäfer, M; Demartines, N

    2010-06-23

    Promising new technologies are emerging in digestive surgery: Natural Orifice Transluminal Endoscopic Surgery (NOTES) and Single Port Access Surgery. They both aim to limit the surgical morbidity by decreasing the number of parietal accesses. The feasibility in human is obviously demonstrated, but numerous issues remain concerning the safety of these techniques. Furthermore, the expected advantages are not clearly demonstrated until now in the literature. In the future, it will be advisable to standardize techniques, in order to allow large clinical studies and to limit the potential complications of these approaches.

  19. Transatlantic Moves to the Market: The United States and the European Union

    ERIC Educational Resources Information Center

    Slaughter, Sheila; Cantwell, Brendan

    2012-01-01

    The theory of academic capitalism is used to explore US and EU marketization trajectories. Comparisons are made along the following dimensions: creation and expansion of intermediating organizations external to universities that promote closer relations between universities and markets; interstitial organizations that emerge from within…

  20. European Study Tour Applications of Experiential Learning Processes in Marketing Education

    ERIC Educational Resources Information Center

    Petkus, Ed, Jr.

    2008-01-01

    This article reports on an application of Kolb's (1981; 1984) experiential learning cycle in the context of international marketing education. Two study tours, in which International Marketing students at a U.S. college visited various cities in Europe, are described, with an emphasis on the ways in which differences in the structure of the tours…

  1. Fixed-Dose Combination Drug Approvals, Patents and Market Exclusivities Compared to Single Active Ingredient Pharmaceuticals

    PubMed Central

    Hao, Jing; Rodriguez-Monguio, Rosa; Seoane-Vazquez, Enrique

    2015-01-01

    Introduction Fixed-dose combinations (FDC) contain two or more active ingredients. The effective patent and exclusivity life of FDC compared to single active ingredient has not been assessed. Objectives Trends in FDA approved FDC in the period 1980–2012 and time lag between approval of FDC and single active ingredients in the combination were assessed, and the effective patent and exclusivity life of FDC was compared with their single active ingredients. Materials and Methods New molecular entities (NMEs), new therapeutic biologics license applications (BLAs) and FDC data were collected from the FDA Orange Book and Drugs@FDA. Analysis included FDC containing one or more NMEs or BLAs at first FDA approval (NMEs-FDC) and only already marketed drugs (Non-NMEs-FDC). Descriptive, Kruskal-Wallis and Wilcoxon Rank Sum analyses were performed. Results During the study period, the FDA approved 28 NMEs-FDC (3.5% of NMEs) and 117 non-NMEs-FDC. FDC approvals increased from 12 in the 1980s to 59 in the 2000s. Non-NMEs-FDC entered the market at a median of 5.43 years (interquartile range 1.74, 10.31) after first FDA approval of single active ingredients in the combination. The Non-NMEs-FDC entered the market at a median of 2.33 years (-7.55, 2.39) before approval of generic single active ingredient. Non-NME-FDC added a median of 9.70 (2.75, 16.24) years to the patent and exclusivity life of the single active ingredients in the combination. Conclusion FDC approvals significantly increased over the last twenty years. Pharmaceutical companies market FDC drugs shortly before the generic versions of the single ingredients enter the market extending the patent and exclusivity life of drugs included in the combination. PMID:26469277

  2. Single European currency and Monetary Union. Macroeconomic implications for pharmaceutical spending.

    PubMed

    Kanavos, P

    1998-01-01

    This article examines the potential implications of introducing a single currency among the Member States of the European Union for national pharmaceutical prices and spending. In doing so, it provides a brief account of the direct effects of introducing a single currency on pharmaceutical business. These are static in nature and include the elimination of exchange rate volatility and transaction costs, increased price transparency and limited potential for parallel trade. It subsequently analyses the potential medium and long term macroeconomic policy choices facing the Member States and their impact on pharmaceutical spending following the introduction of a single currency. These include policy directions in order to meet the Maastricht convergence criteria in the run-up to forming an Economic and Monetary Union (EMU) and the implications of EMU on national macroeconomic policy thereafter. This article argues that the necessity for tight fiscal policies across the EU and, in particular, in those Member States facing high budget deficits and overall debt levels, will continue to exert considerable downward pressure on pharmaceutical spending.

  3. European Labor Market in Critical Times: The Importance of Flexicurity Confirmed

    ERIC Educational Resources Information Center

    Caspar, Sigried; Hartwig, Ines; Moench, Barbara

    2012-01-01

    The midterm impact of the economic crisis on the employment situation in the EU member states varied largely (European Commission, 2010a, Chapter 1). Whereas the Baltic States, Ireland, and above all Spain registered job losses of more than 10 percent from immediately before to after the crisis, that is, between the second quarter of 2008 and the…

  4. Market projections and factors influencing the development of new products and energy derived from agricultural crops in the European Union

    SciTech Connect

    Knight, B.E.A.; Houghton, T.M.

    1995-11-01

    Following the 1992 revision of the Common Agricultural Policy in the European Union, it is projected that 25-50 million acres of arable land currently used for food production could be surplus to requirements by 2000. This strategic study was carried out in order to assess factors that will determine, over the next twenty years, the use of a range of crops for non food outlets. Analysis of published research and economic reports and interviews with legislators and opinion leaders in different Member States was carried out. Five defined market sectors were covered: (i) biomass crops for the generation of heat and electricity, (ii) oilseed and cereal crops as sources of transport fuel, (iii) products from vegetable oils, (iv) products from starch and sugar, and (v) products from fibre crops. Opportunities and constraints were ranked and maximum and minimum land use requirements forecast for each sector. Biomass for electricity is projected to need most land, up to 20 million acres by 2015, if all factors are favourable. In the shorter term, crops grown to produce liquid transport fuel are likely to show the most rapid expansion in area. Market demand for environmentally superior products will be a driving force despite, currently, poor relative economics in comparison with fossil fuel derived products. Better integration between crop production and the end markets will be essential.

  5. Solution of time fractional Black-Scholes European option pricing equation arising in financial market

    NASA Astrophysics Data System (ADS)

    Ravi Kanth, A. S. V.; Aruna, K.

    2016-12-01

    In this paper, we present fractional differential transform method (FDTM) and modified fractional differential transform method (MFDTM) for the solution of time fractional Black-Scholes European option pricing equation. The method finds the solution without any discretization, transformation, or restrictive assumptions with the use of appropriate initial or boundary conditions. The efficiency and exactitude of the proposed methods are tested by means of three examples.

  6. Technological growth of fuel efficiency in european automobile market 1975–2015

    SciTech Connect

    Hu, Kejia; Chen, Yuche

    2016-08-29

    This paper looks at the technological growth of new car fleet fuel efficiency in the European Union between 1975 and 2015. According to the analysis results, from1975 to 2006 the fuel efficiency technology improvements were largely offset by vehicles' increased weight, engine size, and consumer amenities such as acceleration capacity. After 2006, downsizing in weight and engine capacity was observed in new car fleet, while fuel consumption decreased by 32% between 2006 and 2015. We adopt a statistical method and find that from 1975 to 2015, a 1% increase in weight would result in 0.3 to 0.5% increments in fuel consumption per 100 km, and a 1% reduction in 0-100 km/h acceleration time would increase fuel consumption by about 0.3%. Impacts of other attributes on fuel consumption are also assessed. To meet the European Union's 2021 fuel consumption target, downsizing of cars, as well as at least maintaining fuel efficiency technology growth trend observed between 2005 and 2015, are needed. Lastly, government policies on controlling improvement in acceleration performance or promoting alternative fuel vehicles are also important to achieve European Union 2021 target.

  7. Technological growth of fuel efficiency in european automobile market 1975–2015

    DOE PAGES

    Hu, Kejia; Chen, Yuche

    2016-08-29

    This paper looks at the technological growth of new car fleet fuel efficiency in the European Union between 1975 and 2015. According to the analysis results, from1975 to 2006 the fuel efficiency technology improvements were largely offset by vehicles' increased weight, engine size, and consumer amenities such as acceleration capacity. After 2006, downsizing in weight and engine capacity was observed in new car fleet, while fuel consumption decreased by 32% between 2006 and 2015. We adopt a statistical method and find that from 1975 to 2015, a 1% increase in weight would result in 0.3 to 0.5% increments in fuelmore » consumption per 100 km, and a 1% reduction in 0-100 km/h acceleration time would increase fuel consumption by about 0.3%. Impacts of other attributes on fuel consumption are also assessed. To meet the European Union's 2021 fuel consumption target, downsizing of cars, as well as at least maintaining fuel efficiency technology growth trend observed between 2005 and 2015, are needed. Lastly, government policies on controlling improvement in acceleration performance or promoting alternative fuel vehicles are also important to achieve European Union 2021 target.« less

  8. The European Teaching Force: Conditions, Mobility and Qualifications.

    ERIC Educational Resources Information Center

    Smith, Janet

    1992-01-01

    Describes the teaching profession in European Common Market (ECM) states, reviewing differences in importance of education, salaries, status, rewards, working conditions, and training. Discusses teacher mobility between member states and feasibility of a single market among ECM states. Describes common market for primary school teachers in…

  9. Labour Market Relevance of European University Education. From Enrolment to Professional Employment in 12 Countries

    ERIC Educational Resources Information Center

    Kivinen, Osmo; Nurmi, Jouni

    2014-01-01

    In accordance with the education policy which puts human capital at its heart, higher education is expected to produce marketable competent professionals in response to the needs of an expansive knowledge-based economy. In one reading, to support competitive knowledge-based economy, higher education students should graduate as young and fast as…

  10. Characterizing emerging European stock markets through complex networks: From local properties to self-similar characteristics

    NASA Astrophysics Data System (ADS)

    Caraiani, Petre

    2012-07-01

    We investigate the properties of the returns of the main emerging stock markets from Europe by means of complex networks. We transform the series of daily returns into complex networks, and analyze the local properties of these networks with respect to degree distributions, clustering, or average line length. We further use the clustering coefficients as quantities describing the local structure of the network, and approach them by using multifractal analysis. We find evidence of scale-free networks and multifractality of clustering coefficients.

  11. Monitoring the informational efficiency of European corporate bond markets with dynamical permutation min-entropy

    NASA Astrophysics Data System (ADS)

    Zunino, Luciano; Bariviera, Aurelio F.; Guercio, M. Belén; Martinez, Lisana B.; Rosso, Osvaldo A.

    2016-08-01

    In this paper the permutation min-entropy has been implemented to unveil the presence of temporal structures in the daily values of European corporate bond indices from April 2001 to August 2015. More precisely, the informational efficiency evolution of the prices of fifteen sectorial indices has been carefully studied by estimating this information-theory-derived symbolic tool over a sliding time window. Such a dynamical analysis makes possible to obtain relevant conclusions about the effect that the 2008 credit crisis has had on the different European corporate bond sectors. It is found that the informational efficiency of some sectors, namely banks, financial services, insurance, and basic resources, has been strongly reduced due to the financial crisis whereas another set of sectors, integrated by chemicals, automobiles, media, energy, construction, industrial goods & services, technology, and telecommunications has only suffered a transitory loss of efficiency. Last but not least, the food & beverage, healthcare, and utilities sectors show a behavior close to a random walk practically along all the period of analysis, confirming a remarkable immunity against the 2008 financial crisis.

  12. European Union centralised procedure for marketing authorisation of oncology drugs: an in-depth review of its efficiency.

    PubMed

    Netzer, Tilo

    2006-03-01

    In the European Union (EU) 20 anticancer agents have been successfully authorised via the Centralised Procedure since its implementation in 1995. Public information on these 20 agents has been reviewed in order to evaluate the effectiveness of the available regulatory mechanisms to facilitate the marketing authorisation of such drugs in the EU. These mechanisms include orphan drug legislation, exceptional circumstances provision and the accelerated evaluation procedure. Based on the fact that the EU orphan drug legislation was not implemented before the year 2000 no conclusions on its effectiveness to facilitate oncology drug development can be drawn today. Much more data are available on the effects of the exceptional circumstances provision, which was used in 6 out of 10 cases over the past four years. An analysis of the clinical data packages indicates that this provision allows authorisation of innovative oncology drugs based on smaller clinical data sets than required for full approval. The accelerated evaluation procedure was used in only one case and significantly reduced the scientific review time at the EU agencies. However, this mechanism does not influence the administrative time at the authorities, which accounted for almost one-third of the overall duration of the EU marketing authorisation procedures for oncology drugs. Revision of the EU drug legislation brings about some changes to the above-described provisions, with the potential for an improvement in the current situation. Thus, its implementation offers the chance to reduce the time that innovative oncology agents take to reach the market, although -- based on experience with the current procedures -- more effort is likely to be required to achieve this goal.

  13. Design and preparation of market baskets of European Union commercial baby foods for the assessment of infant exposure to food chemicals and to their effects.

    PubMed

    Piccinelli, R; Pandelova, M; Le Donne, C; Ferrari, M; Schramm, K-W; Leclercq, C

    2010-10-01

    The assessment of acute and chronic dietary exposure to contaminants in baby foods is needed to ensure healthy infant growth. Monthly European Union market baskets of commercial baby foods were designed for the first 9 months of life by the 'babyfood' study group of the CASCADE Network of Excellence for the specific purpose of assessing exposure to potentially toxic substances in infants fed with such foods. The present paper reports the different steps that led to the preparation of monthly pooled samples of commercial baby foods ('Infant formulae and follow-on formulae' and 'Other baby foods') that may constitute the extreme case of the diet for an infant who would not be breast fed at all. Several market baskets were generated for an 'average European Union infant' and for infants of four selected countries (Italy, Sweden, Spain, and the Slovakia), fed with either milk infant formulae, soy infant formulae or hypoallergenic infant formulae and weaned (at the fifth month) with commercial baby foods and beverages available on the European Union market. Market share data for 2007 for baby foods were used to design the baskets. Holding companies and the name of all their products were identified. Monthly diets for European Union infants were elaborated in terms of food categories (e.g. infant cereals) of typologies of products (e.g. infant cereals without gluten) and of a specific product. The number of baskets generated was 30 for 'Infant formulae and follow-on formulae' (including 62 products) and 13 for 'Other baby foods' (including 35 products). These market baskets were designed to be used for the determination of certain contaminants and nutrients in the diet of European Union infants and for the assessment of their effects on infant health.

  14. Reimbursement of licensed cell and gene therapies across the major European healthcare markets

    PubMed Central

    Jørgensen, Jesper; Kefalas, Panos

    2015-01-01

    Objective The aim of this research is to identify the pricing, reimbursement, and market access (P&R&MA) considerations most relevant to advanced therapy medicinal products (ATMPs) in the Big5EU, and to inform their manufacturers about the key drivers for securing adoption at a commercially viable reimbursed price. Methodology The research was structured following three main steps: 1) Identifying the market access pathways relevant to ATMPs through secondary research; 2) Validating the secondary research findings and addressing any data gaps in primary research, by qualitative interviews with national, regional, and local-level payers and their clinical and economic advisors; 3) Collating of primary and secondary findings to compare results across countries. Results The incremental clinical benefit forms the basis for all P&R&MA processes. Budget impact is a key consideration, regardless of geography. Cost-effectiveness analyses are increasingly applied; however, only the United Kingdom has a defined threshold that links the cost per quality-adjusted life year (QALY) specifically and methodologically to the reimbursed price. Funding mechanisms to enable adoption of new and more expensive therapies exist in all countries, albeit to varying extents. Willingness to pay is typically higher in smaller patient populations, especially in populations with high disease burden. Outcomes modelling and risk-sharing agreements (RSAs) provide strategies to address the data gap and uncertainties often associated with trials in niche populations. Conclusions The high cost of ATMPs, coupled with the uncertainty at launch around their long-term claims, present challenges for their adoption at a commercially viable reimbursed price. Targeting populations of high disease burden and unmet needs may be advantageous, as the potential for improvement in clinical benefit is greater, as well as the potential for capitalising on healthcare cost offsets. Also, targeting small populations can

  15. Getting ready for the marriage market? The association between divorce risks and investments in attractive body mass among married Europeans.

    PubMed

    Lundborg, Petter; Nystedt, Paul; Lindgren, Björn

    2007-07-01

    This article explores to what extent married middle-aged individuals in Europe are governed by the risk of experiencing divorce, when shaping their physical appearance. The main result is that divorce risks, proxied by national divorce rates, are negatively connected to body mass index (BMI) among married individuals but unrelated to BMI among singles. Hence, it seems that married people in societies where divorce risks are high are more inclined to invest in their outer appearance. One interpretation is that high divorce rates make married people prepare for a potential divorce and future return to the marriage market.

  16. Deodorants on the European market: quantitative chemical analysis of 21 fragrances.

    PubMed

    Rastogi, S C; Johansen, J D; Frosch, P; Menné, T; Bruze, M; Lepoittevin, J P; Dreier, B; Andersen, K E; White, I R

    1998-01-01

    Deodorants are one of the most frequently used types of cosmetics and side-effects from them are common. Recent studies relate perfume allergy to this type of product. 73 deodorants were analyzed by gas chromatography--mass spectrometry for the determination of the contents of 7 wellknown fragrance allergens from the fragrance mix and 14 other commonly used fragrance materials. The deodorants were purchased at retail outlets in 5 European countries. It was found that in general, fragrance mix ingredients were more frequently present in vapo- and aerosol sprays than in roll-on products. The levels of the fragrance mix substances ranged from 0.0001-0.2355%. The products investigated contained cinnamic aldehyde and isoeugenol less frequently (17% and 29% respectively), and eugenol and geraniol most frequently (57% and 76% respectively). The 14 other fragrance materials were found in 40-97% of the deodorants, with hedione and benzyl acetate the most frequently found substances. The concentration of these 14 substances ranged from 0.0001-2.7%. It is concluded that the levels of cinnamic aldehyde and isoeugenol found in the deodorants could prove to be relevant for elicitation of contact dermatitis. No conclusions could be drawn about the other fragrance mix constituents, as threshold levels in sensitized individuals have not been investigated. Furthermore, all of the fragrance materials investigated were frequently found in deodorants and, apart from the fragrance mix ingredients, the extent of problems with sensitization to these fragrance materials is largely unknown.

  17. Occurrence of halogenated flame retardants in commercial seafood species available in European markets.

    PubMed

    Aznar-Alemany, Òscar; Trabalón, Laura; Jacobs, Silke; Barbosa, Vera Liane; Tejedor, Margarita Fernández; Granby, Kit; Kwadijk, Christiaan; Cunha, Sara C; Ferrari, Federico; Vandermeersch, Griet; Sioen, Isabelle; Verbeke, Wim; Vilavert, Lolita; Domingo, José L; Eljarrat, Ethel; Barceló, Damià

    2016-12-24

    PBDEs (congeners 28, 47, 99, 100, 153, 154, 183, 209), HBCD (α, β, γ), emerging brominated flame retardants (PBEB, HBB and DBDPE), dechloranes (Dec 602, 603, 604, syn- and anti-DP), TBBPA, 2,4,6-TBP and MeO-PBDEs (8 congeners) were analysed in commercial seafood samples from European countries. Levels were similar to literature and above the environmental quality standards (EQS) limit of the Directive 2013/39/EU for PBDEs. Contaminants were found in 90.5% of the seafood samples at n. d.-356 ng/g lw (n. d.-41.1 ng/g ww). DBDPE was not detected and 2,4,6-TBP was detected only in mussels, but at levels comparable to those of PBDEs. Mussel and seabream were the most contaminated species and the Mediterranean Sea (FAO Fishing Area 37) was the most contaminated location. The risk assessment revealed that there was no health risk related to the exposure to brominated flame retardants via seafood consumption. However, a refined risk assessment for BDE-99 is of interest in the future. Moreover, the cooking process concentrated PBDEs and HBB.

  18. Marketing.

    PubMed

    Chambers, David W

    2010-01-01

    There is not enough marketing of dentistry; but there certainly is too much selling of poor quality service that is being passed off as dentistry. The marketing concept makes the patient and the patients' needs the ultimate criteria of marketing efforts. Myths and good practices for effective marketing that will promote oral health are described under the traditional four "Ps" categories of "product" (best dental care), "place" (availability), "promotion" (advertising and other forms of making patients aware of available services and how to use them), and "price" (the total cost to patients of receiving care).

  19. Preliminary Results From the C-Pulse® OPTIONS HF European Multicenter Post-Market Study

    PubMed Central

    Schulz, Antonia; Krabatsch, Thomas; Schmitto, Jan D.; Hetzer, Roland; Seidel, Mirko; Dohmen, Pascal M.; Hotz, Holger

    2016-01-01

    Background The C-Pulse® System is an extra-aortic balloon counterpulsation device. It is used to treat patients with heart failure disease in NYHA functional class III or ambulatory class IV. Material/Methods We present preliminary site-reported 6-month data from 3 centers in Germany as part of the prospective observational post-market OPTIONS HF study. Results Between May 2013 and March 2014, the C-Pulse System was implanted in 8 patients (7 male) with a mean age of 61.6±9.3 years. Four had ischemic and 4 had non-ischemic cardiomyopathy. No stroke, myocardial infarction, major bleeding, or major infection due to the device were reported. One patient developed non-device-related refractory tachycardia with worsening heart failure 12 h after surgery and underwent left ventricular assist device implantation. Within 6 months of observation, functional status improved from NYHA III to II in 5 patients, and 2 remained in NYHA III. Mean left ventricular ejection fraction increased from 24.3±7.9% to 44.5±4.5% (p<0.0001). Mean Kansas City Cardiomyopathy Questionnaire overall score improved from 28.6±19.1 to 59.1±22.5 (p=0.0183). Six-minute walk test was performed in 6 out of 7 patients at follow-up. The mean distance improved from 252.0±85.1 m to 279.2±87.5 m (p>0.05). One patient was weaned off the device after 6 months of support. Conclusions The C-Pulse System provides a therapeutic option for patients with moderate-to-severe heart failure and seems to improve quality of life and cardiac function over time. PMID:26887528

  20. Screening survey of deoxynivalenol in beer from the European market by an enzyme-linked immunosorbent assay.

    PubMed

    Papadopoulou-Bouraoui, A; Vrabcheva, T; Valzacchi, S; Stroka, J; Anklam, E

    2004-06-01

    Deoxynivalenol (DON) was analysed in 313 beer samples collected from the European retail market using a commercially available immunoassay kit (enzyme-linked immunosorbent assay, ELISA). The incidence rate was about 87%, while most samples (73%) had contamination levels lower than 20 ng m(-1). The contamination ranged between 4.0 and 56.7 ng ml(-1), with an average of 13.5 ng ml(-1). A statistically significant correlation between alcohol levels and DON contamination was found, as well as a significant difference between bottom, top and spontaneous fermenting beers. Twenty-seven beer samples were compared using a second ELISA kit and a good correlation was obtained between the two kits (r = 0.93). Although when compared with gas chromatography-mass spectrometry the ELISA tended to overestimate the results, a good correlation (r=0.94) between the two methods was observed. Monitoring of DON in beer is important considering that DON production is dependent on the weather and that it can contribute significantly to the tolerable daily intake of DON, especially for frequent beer consumers.

  1. A European perspective--the European clinical research infrastructures network.

    PubMed

    Demotes-Mainard, J; Kubiak, C

    2011-11-01

    Evaluating research outcomes requires multinational cooperation in clinical research for optimization of treatment strategies and comparative effectiveness research, leading to evidence-based practice and healthcare cost containment. The European Clinical Research Infrastructures Network (ECRIN) is a distributed ESFRI (European Strategy Forum on Research Infrastructures) roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients, and unlocking latent scientific potential. Servicing multinational trials started during its preparatory phase, and ECRIN will now apply for an ERIC (European Research Infrastructures Consortium) status by 2011. By creating a single area for clinical research in Europe, this achievement will contribute to the implementation of the Europe flagship initiative 2020 'Innovation Union', whose objectives include defragmentation of the research and education capacity, tackling the major societal challenges starting with the area of healthy ageing, and removing barriers to bring ideas to the market.

  2. Marketing.

    ERIC Educational Resources Information Center

    Appel, David L.

    This booklet suggests ways in which institutions--Catholic schools in particular--can move beyond public relations and advertising to engage in the broader arena of marketing with its focus on consumer satisfaction. The first of the book's three chapters reviews the concept of marketing, providing definitions of key terms, clarification of…

  3. Marketing.

    ERIC Educational Resources Information Center

    Maust, Robert N.

    1985-01-01

    Although college administrators may be committed to the concept and need for institutional marketing, even a well-developed marketing plan may not work if it is not clearly organized to address special needs. This article reviews management fads, how to make jargon operational, organizational dynamics, and monitoring fads. (MSE)

  4. Products containing microorganisms as a tool in integrated pest management and the rules of their market placement in the European Union.

    PubMed

    Matyjaszczyk, Ewa

    2015-09-01

    Products containing microorganisms (bacteria, fungi and viruses) can be used in plant production as an intervention as well as a prevention method for pest control. Their utilisation is strictly in line with the principles of integrated pest management, provided that they are effective and safe. The rules of registration of microorganisms for crop production in the European Union differ, depending on whether they are placed on the market as plant protection products or not. For over 20 years, uniform rules for registration of plant protection products have been in force. Currently, 36 microorganisms marked up to the strain are approved for use in pest control in the Community. The decision concerning market placement of plant protection products containing approved microorganisms is issued for each member state separately. The approaches to market placement of other products with microorganisms differ within the EU, ranging from a complete lack of requirements to long and costly registration procedures.

  5. The European job market

    ERIC Educational Resources Information Center

    Miller, Ruth

    1974-01-01

    Employment exchange between countries in Europe is in need of much updating. Article considered a report by the British Association for Commercial and Industrial Education which dealt with social conditions that bedevil harmonization. (Author/RK)

  6. Identification of Pyrus single nucleotide polymorphisms (SNPs) and evaluation for genetic mapping in European pear and interspecific Pyrus hybrids.

    PubMed

    Montanari, Sara; Saeed, Munazza; Knäbel, Mareike; Kim, YoonKyeong; Troggio, Michela; Malnoy, Mickael; Velasco, Riccardo; Fontana, Paolo; Won, KyungHo; Durel, Charles-Eric; Perchepied, Laure; Schaffer, Robert; Wiedow, Claudia; Bus, Vincent; Brewer, Lester; Gardiner, Susan E; Crowhurst, Ross N; Chagné, David

    2013-01-01

    We have used new generation sequencing (NGS) technologies to identify single nucleotide polymorphism (SNP) markers from three European pear (Pyrus communis L.) cultivars and subsequently developed a subset of 1096 pear SNPs into high throughput markers by combining them with the set of 7692 apple SNPs on the IRSC apple Infinium® II 8K array. We then evaluated this apple and pear Infinium® II 9K SNP array for large-scale genotyping in pear across several species, using both pear and apple SNPs. The segregating populations employed for array validation included a segregating population of European pear ('Old Home'×'Louise Bon Jersey') and four interspecific breeding families derived from Asian (P. pyrifolia Nakai and P. bretschneideri Rehd.) and European pear pedigrees. In total, we mapped 857 polymorphic pear markers to construct the first SNP-based genetic maps for pear, comprising 78% of the total pear SNPs included in the array. In addition, 1031 SNP markers derived from apple (13% of the total apple SNPs included in the array) were polymorphic and were mapped in one or more of the pear populations. These results are the first to demonstrate SNP transferability across the genera Malus and Pyrus. Our construction of high density SNP-based and gene-based genetic maps in pear represents an important step towards the identification of chromosomal regions associated with a range of horticultural characters, such as pest and disease resistance, orchard yield and fruit quality.

  7. European Telecommunications Conference. Strategic Planning for the 1990s

    NASA Astrophysics Data System (ADS)

    Blackburn, J. F.

    1990-06-01

    The European Telecommunications Conference Strategic Planning for the 1990s provided information to delegates and their companies on strategic planning for the European market, particularly after the advent of the European Single Market at the end of 1992. The conference objective was to examine the impact of the initiatives of the European Commission (EC) and the changing attitudes to service provision by public and private sector organizations on industry and marketing. Organized by Blenheim Online and Logica, 40 delegates attended this conference, mainly from Europe, but with a few from the U.S. The papers were designed to illuminate such questions as emerging market sectors, impact of U.S telecommunications organizations in Europe, mergers and acquisition, standards, and value-added services.

  8. "Into the Melting Pot": The Development of a European Dimension in a 4-Year Programme in Languages and International Marketing.

    ERIC Educational Resources Information Center

    Davis, R. Leslie

    In response to the need for improved international trade in Ireland, an undergraduate program of applied languages and international marketing was developed at the National Institute for Higher Education, a unique Irish technological university in Dublin. In the first year, students study French and German and four business subjects (marketing,…

  9. An Interactive Microcomputer Program for Teaching the Impacts of Alternative Policy Sets in the Market for a Single Commodity.

    ERIC Educational Resources Information Center

    Li, Elton; Stoecker, Arthur

    1995-01-01

    Describes a computer software program where students define alternative policy sets and compare their effects on the welfare of consumers, producers, and the public sector. Policy sets may be a single tax or quota or a mix of taxes, subsidies, and/or price supports implemented in the marketing chain. (MJP)

  10. 77 FR 71195 - Final Fair Market Rents for the Housing Choice Voucher Program and Moderate Rehabilitation Single...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT Final Fair Market Rents for the Housing Choice Voucher Program and Moderate Rehabilitation Single Room Occupancy Program Fiscal Year 2013; Revised AGENCY: Office of the Assistant...

  11. 75 FR 12252 - Final Fair Market Rents for the Housing Choice Voucher Program and Moderate Rehabilitation Single...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT Final Fair Market Rents for the Housing Choice Voucher Program and Moderate Rehabilitation Single Room Occupancy Program for Fiscal Year 2010; Revised Correction AGENCY: Office of...

  12. Education and European integration

    NASA Astrophysics Data System (ADS)

    Lowe, John

    1992-11-01

    The main purpose of this article is to discuss the implications for education and training of the movement towards integration in Europe in the historic context of the creation of a single market within the European Community (EC) and the end of the Communist regimes in Central and Eastern Europe. The experience of the EC is used to illustrate trends and problems in the development of international cooperation in education and training. Common concerns and priorities throughout the new Europe are then identified and discussed. These include the pursuit of quality in schooling, efforts to serve the interests of disadvantaged learners, and the treatment of European Studies in the curriculum, including the improvement of the teaching of foreign languages.

  13. The European Conformity Assessment Procedures and the Quality Assurance Instruments for Personal Protective Equipment in the Internal Market.

    PubMed

    Lambert, Joachim

    1995-01-01

    Conformity assessment procedures prescribed by European legislation are presented and their concrete implementation is illustrated by the example of personal protective equipment (PPE). The different categories of PPE defined by Council Directive 89/686/EEC are explained with reference to the applicable conformity assessment elements. Quality assurance of production is presented as the central element of the conformity assessment procedure for complex PPE. Special emphasis is put on the necessity of having a regular exchange of views and information among notified bodies in Europe. Ways in which third countries can eventually carry out conformity assessment on the basis of a contract with the European Community Commission are explained.

  14. Quality Assurance in the European Higher Education Area: The Emergence of a German Market for Quality Assurance Agencies

    ERIC Educational Resources Information Center

    Serrano-Velarde, Kathia E.

    2008-01-01

    Most European countries have introduced systematic quality assurance as part of an overall governance reform aimed at enhancing universities' autonomy. Researchers and economic entrepreneurs tend, however, to underestimate the political dimension of accreditation and evaluation when they consider the contribution of quality assurance to the…

  15. Labour Market Outcomes of Vocational Education in Europe: Evidence from the European Union Labour Force Survey. Research Paper No 32

    ERIC Educational Resources Information Center

    Cedefop - European Centre for the Development of Vocational Training, 2013

    2013-01-01

    This report focuses on the outcomes of vocational education and, in particular, on the transition from education to work in the current employment situation for young adults in the European Union. Using anonymised microdata from the EU labour force survey 2009 ad hoc module, this is one of the first studies to undertake a large cross-country…

  16. A comprehensive simulation framework for imaging single particles and biomolecules at the European X-ray Free-Electron Laser

    PubMed Central

    Yoon, Chun Hong; Yurkov, Mikhail V.; Schneidmiller, Evgeny A.; Samoylova, Liubov; Buzmakov, Alexey; Jurek, Zoltan; Ziaja, Beata; Santra, Robin; Loh, N. Duane; Tschentscher, Thomas; Mancuso, Adrian P.

    2016-01-01

    The advent of newer, brighter, and more coherent X-ray sources, such as X-ray Free-Electron Lasers (XFELs), represents a tremendous growth in the potential to apply coherent X-rays to determine the structure of materials from the micron-scale down to the Angstrom-scale. There is a significant need for a multi-physics simulation framework to perform source-to-detector simulations for a single particle imaging experiment, including (i) the multidimensional simulation of the X-ray source; (ii) simulation of the wave-optics propagation of the coherent XFEL beams; (iii) atomistic modelling of photon-material interactions; (iv) simulation of the time-dependent diffraction process, including incoherent scattering; (v) assembling noisy and incomplete diffraction intensities into a three-dimensional data set using the Expansion-Maximisation-Compression (EMC) algorithm and (vi) phase retrieval to obtain structural information. We demonstrate the framework by simulating a single-particle experiment for a nitrogenase iron protein using parameters of the SPB/SFX instrument of the European XFEL. This exercise demonstrably yields interpretable consequences for structure determination that are crucial yet currently unavailable for experiment design. PMID:27109208

  17. A comprehensive simulation framework for imaging single particles and biomolecules at the European X-ray Free-Electron Laser

    SciTech Connect

    Yoon, Chun Hong; Yurkov, Mikhail V.; Schneidmiller, Evgeny A.; Samoylova, Liubov; Buzmakov, Alexey; Jurek, Zoltan; Ziaja, Beata; Santra, Robin; Loh, N. Duane; Tschentscher, Thomas; Mancuso, Adrian P.

    2016-04-25

    The advent of newer, brighter, and more coherent X-ray sources, such as X-ray Free-Electron Lasers (XFELs), represents a tremendous growth in the potential to apply coherent X-rays to determine the structure of materials from the micron-scale down to the Angstrom-scale. There is a significant need for a multi-physics simulation framework to perform source-to-detector simulations for a single particle imaging experiment, including (i) the multidimensional simulation of the X-ray source; (ii) simulation of the wave-optics propagation of the coherent XFEL beams; (iii) atomistic modelling of photon-material interactions; (iv) simulation of the time-dependent diffraction process, including incoherent scattering; (v) assembling noisy and incomplete diffraction intensities into a three-dimensional data set using the Expansion-Maximisation-Compression (EMC) algorithm and (vi) phase retrieval to obtain structural information. Furthermore, we demonstrate the framework by simulating a single-particle experiment for a nitrogenase iron protein using parameters of the SPB/SFX instrument of the European XFEL. This exercise demonstrably yields interpretable consequences for structure determination that are crucial yet currently unavailable for experiment design.

  18. A comprehensive simulation framework for imaging single particles and biomolecules at the European X-ray Free-Electron Laser

    DOE PAGES

    Yoon, Chun Hong; Yurkov, Mikhail V.; Schneidmiller, Evgeny A.; ...

    2016-04-25

    The advent of newer, brighter, and more coherent X-ray sources, such as X-ray Free-Electron Lasers (XFELs), represents a tremendous growth in the potential to apply coherent X-rays to determine the structure of materials from the micron-scale down to the Angstrom-scale. There is a significant need for a multi-physics simulation framework to perform source-to-detector simulations for a single particle imaging experiment, including (i) the multidimensional simulation of the X-ray source; (ii) simulation of the wave-optics propagation of the coherent XFEL beams; (iii) atomistic modelling of photon-material interactions; (iv) simulation of the time-dependent diffraction process, including incoherent scattering; (v) assembling noisy andmore » incomplete diffraction intensities into a three-dimensional data set using the Expansion-Maximisation-Compression (EMC) algorithm and (vi) phase retrieval to obtain structural information. Furthermore, we demonstrate the framework by simulating a single-particle experiment for a nitrogenase iron protein using parameters of the SPB/SFX instrument of the European XFEL. This exercise demonstrably yields interpretable consequences for structure determination that are crucial yet currently unavailable for experiment design.« less

  19. A comprehensive simulation framework for imaging single particles and biomolecules at the European X-ray Free-Electron Laser.

    PubMed

    Yoon, Chun Hong; Yurkov, Mikhail V; Schneidmiller, Evgeny A; Samoylova, Liubov; Buzmakov, Alexey; Jurek, Zoltan; Ziaja, Beata; Santra, Robin; Loh, N Duane; Tschentscher, Thomas; Mancuso, Adrian P

    2016-04-25

    The advent of newer, brighter, and more coherent X-ray sources, such as X-ray Free-Electron Lasers (XFELs), represents a tremendous growth in the potential to apply coherent X-rays to determine the structure of materials from the micron-scale down to the Angstrom-scale. There is a significant need for a multi-physics simulation framework to perform source-to-detector simulations for a single particle imaging experiment, including (i) the multidimensional simulation of the X-ray source; (ii) simulation of the wave-optics propagation of the coherent XFEL beams; (iii) atomistic modelling of photon-material interactions; (iv) simulation of the time-dependent diffraction process, including incoherent scattering; (v) assembling noisy and incomplete diffraction intensities into a three-dimensional data set using the Expansion-Maximisation-Compression (EMC) algorithm and (vi) phase retrieval to obtain structural information. We demonstrate the framework by simulating a single-particle experiment for a nitrogenase iron protein using parameters of the SPB/SFX instrument of the European XFEL. This exercise demonstrably yields interpretable consequences for structure determination that are crucial yet currently unavailable for experiment design.

  20. The European Mobile System (EMS)

    NASA Technical Reports Server (NTRS)

    Jongejans, A.; Rogard, R.; Mistretta, I.; Ananasso, F.

    1993-01-01

    The European Space Agency is presently procuring an L band payload in order to promote a regional European L band system coping with the specific needs of the European market. The payload, and the two communications systems to be supported, are described below. The potential market for EMS in Europe is discussed.

  1. A detailed heterogeneous agent model for a single asset financial market with trading via an order book.

    PubMed

    Mota Navarro, Roberto; Larralde, Hernán

    2017-01-01

    We present an agent based model of a single asset financial market that is capable of replicating most of the non-trivial statistical properties observed in real financial markets, generically referred to as stylized facts. In our model agents employ strategies inspired on those used in real markets, and a realistic trade mechanism based on a double auction order book. We study the role of the distinct types of trader on the return statistics: specifically, correlation properties (or lack thereof), volatility clustering, heavy tails, and the degree to which the distribution can be described by a log-normal. Further, by introducing the practice of "profit taking", our model is also capable of replicating the stylized fact related to an asymmetry in the distribution of losses and gains.

  2. A detailed heterogeneous agent model for a single asset financial market with trading via an order book

    PubMed Central

    2017-01-01

    We present an agent based model of a single asset financial market that is capable of replicating most of the non-trivial statistical properties observed in real financial markets, generically referred to as stylized facts. In our model agents employ strategies inspired on those used in real markets, and a realistic trade mechanism based on a double auction order book. We study the role of the distinct types of trader on the return statistics: specifically, correlation properties (or lack thereof), volatility clustering, heavy tails, and the degree to which the distribution can be described by a log-normal. Further, by introducing the practice of “profit taking”, our model is also capable of replicating the stylized fact related to an asymmetry in the distribution of losses and gains. PMID:28245251

  3. Exploring the Governance of Polish Public Higher Education: Balancing Restored Historical Legacies with Europeanization and Market Pressures

    ERIC Educational Resources Information Center

    Dobbins, Michael

    2015-01-01

    This article places developments in Polish public higher education (HE) in the broader context of the literature on HE governance and, in particular, marketization. The Polish case stands out due to the parallel existence of prestigious large universities with long histories of scientific advancement and the largest number of private HE…

  4. Gray marketing of pharmaceuticals.

    PubMed

    Chaudhry, P E; Walsh, M G

    1995-01-01

    Pharmaceutical marketers in the European Union are constrained by regulated prices, opening up opportunities for gray marketers. The authors investigate the legal framework that regulates gray markets by summarizing and analyzing relevant European Court of Justice decisions that favor gray marketers and actually foster parallel trade. Before marketing managers can develop effective strategies in this marketplace, they must first understand the precedents of the legal system in which they will be operating.

  5. On the dynamic dependence and asymmetric co-movement between the US and Central and Eastern European transition markets

    NASA Astrophysics Data System (ADS)

    Boubaker, Heni; Raza, Syed Ali

    2016-10-01

    In this paper, we attempt to evaluate the time-varying and asymmetric co-movement of CEE equity markets with the US stock markets around the subprime crisis and the resulting global financial crisis. The econometric approach adopted is based on recent development of time-varying copulas. For that, we propose a new class of time-varying copulas that allows for long memory behavior in both marginal and joint distributions. Our empirical approach relies on the flexibility and usefulness of bivariate copulas that allow to model not only the dynamic co-movement through time but also to account for any extreme interaction, nonlinearity and asymmetry in the co-movement patterns. The time-varying dependence structure can be also modeled conditionally on the economic policy uncertainty index of the crisis country. Empirical results show strong evidence of co-movement between the US and CEE equity markets and find that the co-movement exhibits large time-variations and asymmetry in the tails of the return distributions.

  6. Will isomalto-oligosaccharides, a well-established functional food in Asia, break through the European and American market? The status of knowledge on these prebiotics.

    PubMed

    Goffin, Dorothee; Delzenne, Nathalie; Blecker, Christophe; Hanon, Emilien; Deroanne, Claude; Paquot, Michel

    2011-05-01

    This critical review article presents the current state of knowledge on isomalto-oligosaccharides, some well known functional oligosaccharides in Asia, to evaluate their potential as emergent prebiotics in the American and European functional food market. It includes first a unique inventory of the different families of compounds which have been considered as IMOs and their specific structure. A description has been given of the different production methods including the involved enzymes and their specific activities, the substrates, and the types of IMOs produced. Considering the structural complexity of IMO products, specific characterization methods are described, as well as purification methods which enable the body to get rid of digestible oligosaccharides. Finally, an extensive review of their techno-functional and nutritional properties enables placing IMOs inside the growing prebiotic market. This review is of particular interest considering that IMO commercialization in America and Europe is a topical subject due to the recent submission by Bioneutra Inc. (Canada) of a novel food file to the UK Food Standards Agency, as well as several patents for IMO production.

  7. Effectiveness of social marketing strategies to reduce youth obesity in European school-based interventions: a systematic review and meta-analysis

    PubMed Central

    Aceves-Martins, Magaly; Llauradó, Elisabet; Tarro, Lucia; Moreno-García, Carlos Francisco; Trujillo Escobar, Tamy Goretty; Giralt, Montse

    2016-01-01

    Context: The use of social marketing to modify lifestyle choices could be helpful in reducing youth obesity. Some or all of the 8 domains of the National Social Marketing Centre’s social marketing benchmark criteria (SMBC) are often used but not always defined in intervention studies. Objective: The aim of this review is to assess the effectiveness of European school-based interventions to prevent obesity relative to the inclusion of SMBC domains in the intervention. Data Sources: The PubMed, Cochrane, and ERIC databases were used. Study Selection: Nonrandomized and randomized controlled trials conducted from 1990 to April 2014 in participants aged 5 to 17 years were included. Data Extraction: After the study selection, the 8 domains of the SMBC were assessed in each included study. Results: Thirty-eight publications were included in the systematic review. For the meta-analysis, randomized controlled trials (RCTs) reporting body mass index or prevalence of overweight and obesity were considered. Eighteen RCTs with a total of 8681 participants included at least 5 SMBC. The meta-analysis showed a small standardized mean difference in body mass index of −0.25 (95%CI, −0.45 to −0.04) and a prevalence of overweight and obesity odds ratio of 0.72 (95%CI, 0.5–0.97). Conclusion: Current evidence indicates that the inclusion of at least 5 SMBC domains in school-based interventions could benefit efforts to prevent obesity in young people. PROSPERO registration number: CRD42014007297. PMID:27018054

  8. Market efficiency in foreign exchange markets

    NASA Astrophysics Data System (ADS)

    Oh, Gabjin; Kim, Seunghwan; Eom, Cheoljun

    2007-08-01

    We investigate the relative market efficiency in financial market data, using the approximate entropy(ApEn) method for a quantification of randomness in time series. We used the global foreign exchange market indices for 17 countries during two periods from 1984 to 1998 and from 1999 to 2004 in order to study the efficiency of various foreign exchange markets around the market crisis. We found that on average, the ApEn values for European and North American foreign exchange markets are larger than those for African and Asian ones except Japan. We also found that the ApEn for Asian markets increased significantly after the Asian currency crisis. Our results suggest that the markets with a larger liquidity such as European and North American foreign exchange markets have a higher market efficiency than those with a smaller liquidity such as the African and Asian markets except Japan.

  9. Potential relationship between single nucleotide polymorphisms used in forensic genetics and diseases or other traits in European population.

    PubMed

    Pombar-Gomez, Maria; Lopez-Lopez, Elixabet; Martin-Guerrero, Idoia; Garcia-Orad Carles, Africa; de Pancorbo, Marian M

    2015-05-01

    Single nucleotide polymorphisms (SNPs) are an interesting option to facilitate the analysis of highly degraded DNA by allowing the reduction of the size of the DNA amplicons. The SNPforID 52-plex panel is a clear example of the use of non-coding SNPs in forensic genetics. However, nonstop advances in studies of genetic polymorphisms are leading to the discovery of new associations between SNPs and diseases. The aim of this study was to perform a comprehensive review of the state of association between the 52 SNPs in the 52-plex panel and diseases or other traits related to their treatment, such as drug response characters. In order to achieve this goal, we have conducted a bioinformatic search for each SNP included in the panel and the SNPs in linkage disequilibrium (LD) with them in the European population (r (2)  > 0.8). A total of 424 SNPs (52 in the panel and 372 in LD) were investigated in PubMed, Scopus, and dbSNP databases. Our results show that three SNPs in the SNPforID 52-plex panel (rs2107612, rs1979255, rs1463729) have been associated with diseases such as hypertension or macular degeneration, as well as drug response. Similarly, three out of the 372 SNPs in LD (rs2107614, r (2)  = 0.859; rs765250, r (2)  = 0.858; rs11064560, r (2)  = 0,887) are also associated with various pathologies. In view of these results, we propose the need for a periodic review of the SNPs used in forensic genetics in order to keep their associations with diseases or related phenotypes updated and to evaluate their continuity in forensic panels for avoiding legal and ethical conflicts.

  10. Comparators (medicinal and non medicinal) for marketing authorization, for public health, for payers and at the European level.

    PubMed

    Berdaï, Driss; Hotton, Jean-Michel; Lechat, Philippe

    2010-01-01

    Drug evaluation is based on comparison. Thus, the choice of the comparator for any new treatment becomes a key issue, especially when there are great differences in medical practice and of use conditions of the comparators depending on the geographical zones and their evolution with time. The choice of the comparators must satisfy sometimes different expectations from the registration authorities and for insurance coverage. The universal comparator that allows answering all the clinical assessment questions does not exist. Placebo, when it can be used, remains a reference for the MA (marketing authorisation) application, but does not exclude the use of the reference drug available on the market and prescribed under optimal efficacy conditions. The reference treatment is sometimes a difficult choice due to the absence of validated therapeutic recommendations or if the recommendations vary depending on the countries. The expansion and international harmonization of prescription guidelines (clinical practice guidelines) would reinforce the robustness and efficiency of clinical research efforts with respect to the relevance of the comparison to reference treatments. This principle also applies to the use of a non-drug comparator when it has been recognized as the reference comparator in the treatment of the pathology in question. In as much as possible, the search for a consensus must also aim at defining in the clinical development recommendations significant thresholds for the size of evaluated effects. Optimization of the information made available after clinical trials could also be helped by the development of use of methodologies that allow assessing superiority on secondary criteria during a non-inferiority study on the main criterion. Finally, the development of early scientific consultations by the Haute Autorité de Santé (HAS, French Health Authority) would contribute to adapt phase III clinical trials better to questions concerning the assessment of the

  11. Ecdysteroid-containing food supplements from Cyanotis arachnoidea on the European market: evidence for spinach product counterfeiting

    NASA Astrophysics Data System (ADS)

    Hunyadi, Attila; Herke, Ibolya; Lengyel, Katalin; Báthori, Mária; Kele, Zoltán; Simon, András; Tóth, Gábor; Szendrei, Kálmán

    2016-12-01

    Phytoecdysteroids like 20-hydroxyecdysone (“ecdysterone”) can exert a mild, non-hormonal anabolic/adaptogenic activity in mammals, and as such, are frequently used in food supplements. Spinach is well-known for its relatively low ecdysteroid content. Cyanotis arachnoidea, a plant native in China, is among the richest sources of phytoecdysteroids, and extracts of this plant are marketed in tons per year amounts via the internet at highly competitive prices. Here we report the investigation of a series of food supplements produced in Germany and claimed to contain spinach extracts. Twelve ecdysteroids including two new compounds were isolated and utilized as marker compounds. A comparative analysis of the products with Cyanotis and spinach extracts provides evidence that they were manufactured from Cyanotis extracts instead of spinach as stated. Based on the chromatographic fingerprints, 20-hydroxyecdysone 2- and 3-acetate are suggested as diagnostic markers for related quality control. This case appears to represent an unusual type of dietary supplement counterfeiting: undeclared extracts from alternative plants would supposedly ‘guarantee’ product efficacy.

  12. Occurrence of brominated flame retardants in black thermo cups and selected kitchen utensils purchased on the European market.

    PubMed

    Samsonek, J; Puype, F

    2013-01-01

    In order to screen for the presence of a recycled polymer waste stream from waste electric and electronic equipment (WEEE), a market survey was conducted on black plastic food-contact articles (FCA). An analytical method was applied combining X-ray fluorescence spectrometry (XRF) with thermal desorption gas chromatography coupled with mass spectrometry (thermal desorption GC-MS). Firstly, XRF spectrometry was applied to distinguish bromine-positive samples. Secondly, bromine-positive samples were submitted for identification by thermal desorption GC-MS. Generally, the bromine-positive samples contained mainly technical decabromodiphenyl ether (decaBDE). Newer types of BFRs such as tetrabromobisphenol A (TBBPA), tetrabromobisphenol A bis(2,3-dibromopropyl), ether (TBBPA-BDBPE) and decabromodiphenylethane (DBDPE), replacing the polybrominated diphenyleters (PBDEs) and polybrominated diphenyls (PBBs), were also identified. In none of the tested samples were PBBs or hexabromocyclododecane (HBCD) found. Polymer identification was carried out using Fourier-transformed infrared spectroscopy measurement (FTIR) on all samples. The results indicate that polypropylene-polyethylene copolymers (PP-PE) and mainly styrene-based food-contact materials, such as acrylonitrile-butadiene-styrene (ABS) have the highest risk of containing BFRs.

  13. Ecdysteroid-containing food supplements from Cyanotis arachnoidea on the European market: evidence for spinach product counterfeiting

    PubMed Central

    Hunyadi, Attila; Herke, Ibolya; Lengyel, Katalin; Báthori, Mária; Kele, Zoltán; Simon, András; Tóth, Gábor; Szendrei, Kálmán

    2016-01-01

    Phytoecdysteroids like 20-hydroxyecdysone (“ecdysterone”) can exert a mild, non-hormonal anabolic/adaptogenic activity in mammals, and as such, are frequently used in food supplements. Spinach is well-known for its relatively low ecdysteroid content. Cyanotis arachnoidea, a plant native in China, is among the richest sources of phytoecdysteroids, and extracts of this plant are marketed in tons per year amounts via the internet at highly competitive prices. Here we report the investigation of a series of food supplements produced in Germany and claimed to contain spinach extracts. Twelve ecdysteroids including two new compounds were isolated and utilized as marker compounds. A comparative analysis of the products with Cyanotis and spinach extracts provides evidence that they were manufactured from Cyanotis extracts instead of spinach as stated. Based on the chromatographic fingerprints, 20-hydroxyecdysone 2- and 3-acetate are suggested as diagnostic markers for related quality control. This case appears to represent an unusual type of dietary supplement counterfeiting: undeclared extracts from alternative plants would supposedly ‘guarantee’ product efficacy. PMID:27929032

  14. Evidence of waste electrical and electronic equipment (WEEE) relevant substances in polymeric food-contact articles sold on the European market.

    PubMed

    Puype, Franky; Samsonek, Jiří; Knoop, Jan; Egelkraut-Holtus, Marion; Ortlieb, Markus

    2015-01-01

    In order to confirm the possibility that recycled fractions from the waste electrical and electronic equipment (WEEE) stream were illegally entering the European market in black polymeric food-contact articles (FCAs), bromine quantification, brominated flame retardant (BFR) identification combined with WEEE-relevant elemental analysis and polymer impurity analysis were performed. From the 10 selected FCAs, seven samples contained a bromine level ranging from 57 to 5975 mg kg(-)(1), which is lower than expected to achieve flame retardancy. The BFRs that were present were tetrabromobisphenol A (TBBPA), decabromodiphenylether (decaBDE), decabromodiphenylethane (DBDPE) and 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE). Typical elements used in electronic equipment and present in WEEE were detected either at trace level or at elevated concentrations. In all cases when bromine was detected at higher concentrations, concurrently antimony was also detected, which confirms the synergetic use of antimony in combination with BFRs. This study describes also the measurement of rare earth elements where combinations of cerium, dysprosium, lanthanum, neodymium, praseodymium and yttrium were detected in four of the seven BFR-positive samples. Additionally, polymer purity was investigated where in all cases foreign polymer fractions were detected. Despite the fact that this study was carried out on a very small amount of samples, there is a significant likelihood that WEEE has been used for the production of FCAs.

  15. Evidence of waste electrical and electronic equipment (WEEE) relevant substances in polymeric food-contact articles sold on the European market

    PubMed Central

    Puype, Franky; Samsonek, Jiří; Knoop, Jan; Egelkraut-Holtus, Marion; Ortlieb, Markus

    2015-01-01

    In order to confirm the possibility that recycled fractions from the waste electrical and electronic equipment (WEEE) stream were illegally entering the European market in black polymeric food-contact articles (FCAs), bromine quantification, brominated flame retardant (BFR) identification combined with WEEE-relevant elemental analysis and polymer impurity analysis were performed. From the 10 selected FCAs, seven samples contained a bromine level ranging from 57 to 5975 mg kg− 1, which is lower than expected to achieve flame retardancy. The BFRs that were present were tetrabromobisphenol A (TBBPA), decabromodiphenylether (decaBDE), decabromodiphenylethane (DBDPE) and 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE). Typical elements used in electronic equipment and present in WEEE were detected either at trace level or at elevated concentrations. In all cases when bromine was detected at higher concentrations, concurrently antimony was also detected, which confirms the synergetic use of antimony in combination with BFRs. This study describes also the measurement of rare earth elements where combinations of cerium, dysprosium, lanthanum, neodymium, praseodymium and yttrium were detected in four of the seven BFR-positive samples. Additionally, polymer purity was investigated where in all cases foreign polymer fractions were detected. Despite the fact that this study was carried out on a very small amount of samples, there is a significant likelihood that WEEE has been used for the production of FCAs. PMID:25599136

  16. Occurrence and stability of inorganic and organic arsenic species in wines, rice wines and beers from Central European market.

    PubMed

    Huang, J-H; Hu, K-N; Ilgen, J; Ilgen, G

    2012-01-01

    We investigated in total 80 wine samples of different types and seven grape juice and 23 beer samples purchased from markets in Central Europe in order to understand the arsenic (As) speciation and help assess the potential As toxicity via intake of alcoholic beverages. Generally, total As concentrations in most samples investigated were below the drinking water limit 10 µg l(-1) published by the World Health Organization (WHO); ranging from 0.46 to 21.0 µg l(-1) As in red and white wines and from 0.75 to 13.4 µg l(-1) As in beers. In addition, concentrations of total As in rice wine and in rice beer were 0.63-6.07 and 3.69-8.23 µg l(-1) As, respectively. The total As concentrations in ice wine ranged from 7.94 to 18.8 µg l(-1) As, significantly higher than in white and red wine. Arsenite predominated as the As species in most of the wine samples, whereas arsenate was the dominant species in rice wine, beer and rice beer. Methyl As components were usually minor components in all wine and beer samples. Monomethylarsonic acid, dimethylarsinic acid and two additional unknown As species were frequently found in grape juice, late harvest and ice wine with higher sweetness. After air exposure, arsenite, arsenate, monomethylarsonic acid and dimethylarsinic acid were stable at 4°C for months, probably due to the acidic conditions of wine and beer samples. The presence of sulfite had little influence on As speciation in wine. Despite the predominance of more toxic arsenite and arsenate in wine and beer, the estimated weekly exposure to As (via consumption of beer, wine and rice wine) is low. The As intake per capita is 6.81 µg from beer, <1.93 µg from wine and 0.88 µg from rice wine, estimated using the median of total As concentration multiplied by the average consumption per capita of the corresponding beverage.

  17. Marketable Skills and Jobs for Single Teen Parents. Final Report, Project No. 480-15170-7-1D05, July 1, 1986 to June 30, 1987.

    ERIC Educational Resources Information Center

    Orange County Public Schools, Orlando, FL.

    The Single Teen Parent Program conducted by the Orange County, Florida, Public Schools, was designed to help single teen parents acquire marketable skills and jobs in order to head independent family units. The parents served were between the ages of 16 and 20 and either had a high school diploma or had passed the General Educational Development…

  18. The Labor Market Orientation of Single Mothers on Welfare in The Netherlands.

    ERIC Educational Resources Information Center

    van Wel, Frits; Knijn, Trudie

    2001-01-01

    Presents a study of 1,049 Dutch single mothers on welfare. Using LISREL, a conceptual model is examined for effects of past and current circumstances of mothers on labor orientation and steps toward employment. A mother's motivation to work is related to care ethos as opposed to work ethos and to problems she anticipates in combining care and…

  19. European registration: today, tomorrow, and beyond.

    PubMed

    Currie, W J

    1990-05-01

    Within the European Community (EC) countries the national pharmaceutical regulatory systems work with varying degrees of efficiency and scientific sophistication. At the Community level the objective of mutual recognition has failed to be realized. To achieve for one registration application within the EC, timely and simultaneous marketing approvals throughout the member states will require changes to the present regulatory procedures or the single market concept for pharmaceuticals will not be realized. To have the greatest chances for success we should move cautiously, identifying and correcting deficiencies in the present procedures, which are known from experience, rather than abandoning such hard won knowledge for a new system with all its attendant potential unknowns and uncertainty. The free movement of drugs within the Internal European market will be a reality. The question remaining is at what price will it be achieved? It is vital to the European economy and consumer, as well as to the innovative pharmaceutical industry, that Europe does not exchange its present competitive edge in the time to develop and register new drugs for a costly drug lag. The experiment must equally succeed as a torch showing the way forward not only for an enlarging European Community, but also to the ever increasing interest in global harmonization of drug regulation.

  20. Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations.

    PubMed

    Li, Ming; Ohi, Kazutaka; Chen, Chunhui; He, Qinghua; Liu, Jie-Wei; Chen, Chuansheng; Luo, Xiong-Jian; Dong, Qi; Hashimoto, Ryota; Su, Bing

    2014-12-01

    Hippocampal volume is a key brain structure for learning ability and memory process, and hippocampal atrophy is a recognized biological marker of Alzheimer's disease. However, the genetic bases of hippocampal volume are still unclear although it is a heritable trait. Genome-wide association studies (GWASs) on hippocampal volume have implicated several significantly associated genetic variants in Europeans. Here, to test the contributions of these GWASs identified genetic variants to hippocampal volume in different ethnic populations, we screened the GWAS-identified candidate single-nucleotide polymorphisms in 3 independent healthy Asian brain imaging samples (a total of 990 subjects). The results showed that none of these single-nucleotide polymorphisms were associated with hippocampal volume in either individual or combined Asian samples. The replication results suggested a complexity of genetic architecture for hippocampal volume and potential genetic heterogeneity between different ethnic populations.

  1. One plus one: Binary alarm calls retain individual signature for longer periods than single-note alarms in the European ground squirrel (Spermophilus citellus).

    PubMed

    Schneiderová, Irena; Volodina, Elena V; Matrosova, Vera A; Volodin, Ilya A

    2017-02-20

    Ground squirrels emit species-specific alarm calls that, among other characteristics, differ by the number of elements. Unlike some species that produce single-element calls, e.g., the Speckled ground squirrel (Spermophilus suslicus), individual European ground squirrels (S. citellus) frequently emit binary-element calls in addition to single-element calls. We tested the hypothesis that the time stability of individuality encoded in alarm calls might be better retained by complicating their acoustic structure by adding extra elements. In a semi-captive colony of individually marked European ground squirrels, we repeatedly recorded alarm calls that were produced towards a human by 12 adult (2 males and 10 females) live-trapped animals. Repeated recordings occurred within time spans of a few hours, 2days and 1year from the first recording. Our results showed that individual calls were highly similar within recordings, but less similar between recordings separated by time spans. Individual differences were best retained when we used nine acoustic variables from both elements. The differences were worse when we used nine variables from only the first element and worst when we used nine variables from only the second element. These results supported the caller reliability hypothesis for species that produce multiple-note alarms, e.g., the Richardson's ground squirrel (S. richardsonii).

  2. Variability, polarimetry, and timing properties of single pulses from PSR J1713+0747 using the Large European Array for Pulsars

    NASA Astrophysics Data System (ADS)

    Liu, K.; Bassa, C. G.; Janssen, G. H.; Karuppusamy, R.; McKee, J.; Kramer, M.; Lee, K. J.; Perrodin, D.; Purver, M.; Sanidas, S.; Smits, R.; Stappers, B. W.; Weltevrede, P.; Zhu, W. W.

    2016-12-01

    Single pulses preserve information about the pulsar radio emission and propagation in the pulsar magnetosphere, and understanding the behaviour of their variability is essential for estimating the fundamental limit on the achievable pulsar timing precision. Here we report the findings of our analysis of single pulses from PSR J1713+0747 with data collected by the Large European Array for Pulsars (LEAP). We present statistical studies of the pulse properties that include distributions of their energy, phase and width. Two modes of systematic sub-pulse drifting have been detected, with a periodicity of seven and three pulse periods. The two modes appear at different ranges of pulse longitude but overlap under the main peak of the integrated profile. No evidence for pulse micro-structure is seen with a time resolution down to 140 ns. In addition, we show that the fractional polarization of single pulses increases with their pulse peak flux density. By mapping the probability density of linear polarization position angle with pulse longitude, we reveal the existence of two orthogonal polarization modes. Finally, we find that the resulting phase jitter of integrated profiles caused by single pulse variability can be described by a Gaussian probability distribution only when at least 100 pulses are used for integration. Pulses of different flux densities and widths contribute approximately equally to the phase jitter, and no improvement on timing precision is achieved by using a sub-set of pulses with a specific range of flux density or width.

  3. The EEC Electronic Information Services Market.

    ERIC Educational Resources Information Center

    Westhoff, Jurgen

    1993-01-01

    Describes the European Information Market Observatory and its purpose of gathering and providing knowledge about the European electronic information services market. Topics include the supply and use of electronic information services, size of the market, structure and policy of market operators, and recent developments in new electronic…

  4. Slow and not so sure: Europe`s long march to electricity market liberalization

    SciTech Connect

    Hancher, L.

    1997-11-01

    Under Europe`s recent Directive on competition in electricity, Member States retain immense autonomy to set the competitive agenda within their borders. The result may well be a distinctly skewed - and far from open - trade in electricity, and little opportunity for even large customers to make a meaningful choice of suppliers. The final adoption last year by The European Council - effectively the legislative body of the European Community - of a regulatory measure requiring gradual liberalization of Europe`s electricity market is an event of more symbolic than real significance. During the seven years it has taken to negotiate and compromise upon a suitable legal framework for electricity market liberalization, the European market itself has moved on. Effective implementation of the newly adopted framework rules is unlikely to be a real catalyst for change in its own right, although it could still be an important force in shaping the direction of liberalization programs already underway at the national level. This article will examine the state of electricity market liberalization in what is now known as the European Union - the loose quasi-federal structure which subsists between the 15 Member States of the European Community (EC). It will focus in part upon the provisions of the new EC Directive on the creation of a single market for electricity, and in part upon the complex changes which are gradually transforming the European electricity market.

  5. Evolving African attitudes to European education: Resistance, pervert effects of the single system paradox, and the ubuntu framework for renewal

    NASA Astrophysics Data System (ADS)

    Assié-Lumumba, N'Dri Thérèse

    2016-02-01

    This paper is a reflection that critically examines the dynamics of education and the struggle by African people for freedom, control of the mind, self-definition and the right to determine their own destiny from the start of colonial rule to the present. The primary methodological approach is historical structuralism, which stipulates that social reality and facts are determined and created by social agents within structural and historical contingencies. It addresses some of the most powerful challenges and contradictions that explain the ineffectiveness of numerous post-independence reforms, and presents the arguments for relevance and use of African languages, for instance, that have been made since the 1960s. The first section of the paper deals with the colonial imperatives for setting new education systems in the colonised societies of Africa and the initial attitudes of the Africans towards colonial education. The second section critically examines the evolving meanings of Western education in Europeanising African societies, the articulation of their rationale and the mechanism for resistance. It analyses the turning point when Africans began to embrace European education and demand it in the colonial and post-independence era. The third section addresses the roots of the inadequacies of received post-colonial education and the imperative of deconstruction and re-appropriation of African education using an ubuntu framework for an African renewal.

  6. Social cues are unlikely to be the single cause for early reproduction in urban European blackbirds (Turdus merula).

    PubMed

    Dominoni, Davide M; Van't Hof, Thomas J; Partecke, Jesko

    2015-04-01

    Despite urban ecology being an established field of research, there is still surprisingly little information about the relative contribution of specific environmental factors driving the observed changes in the behavior and physiology of city dwellers. One of the most reported effects of urbanization is the advanced phenology observed in birds. Many factors have been suggested to underline such effect, including warmer microclimate, anthropogenic food supply and light pollution. Since social stimuli are known to affect reproductive timing and breeding density is usually higher in urban populations compared to rural ones, we experimentally tested whether social interactions could advance the onset of reproduction in European blackbirds (Turdus merula). We housed male blackbirds of rural and urban origins with or without a conspecific female, and recorded their seasonal variation in gonadal size and production of luteinizing hormone (LH). Paired and unpaired males of both urban and rural origins did not significantly differ in their timing of gonadal growth. Moreover, rural and urban birds did not differ in their response to the social stimuli, rather they became reproductively active at the same time, a result that confirms previous studies that attributed the difference in reproductive timing observed in the field to phenotypic plasticity. We conclude that social stimuli do not contribute substantially to the observed early onset of reproductive physiology in urban bird species, rather other factors such as light pollution are likely to be stronger drivers of these physiological changes.

  7. Foreign Language Teaching Policies and European Unity: The Dutch National Action Programme.

    ERIC Educational Resources Information Center

    van Els, Theo. J. M.; van Hest, Erna W. C. M.

    1990-01-01

    Describes and reviews the Dutch National Action Programme (NAP) on Foreign Languages, instituted in anticipation of the demands of the 1992 Single European Market. The increasing demand for foreign languages is confirmed, some shortcomings of the current program regarding French and German language learning are identified, and recommendations for…

  8. Single crystal diamond detector measurements of deuterium-deuterium and deuterium-tritium neutrons in Joint European Torus fusion plasmas.

    PubMed

    Cazzaniga, C; Sundén, E Andersson; Binda, F; Croci, G; Ericsson, G; Giacomelli, L; Gorini, G; Griesmayer, E; Grosso, G; Kaveney, G; Nocente, M; Perelli Cippo, E; Rebai, M; Syme, B; Tardocchi, M

    2014-04-01

    First simultaneous measurements of deuterium-deuterium (DD) and deuterium-tritium neutrons from deuterium plasmas using a Single crystal Diamond Detector are presented in this paper. The measurements were performed at JET with a dedicated electronic chain that combined high count rate capabilities and high energy resolution. The deposited energy spectrum from DD neutrons was successfully reproduced by means of Monte Carlo calculations of the detector response function and simulations of neutron emission from the plasma, including background contributions. The reported results are of relevance for the development of compact neutron detectors with spectroscopy capabilities for installation in camera systems of present and future high power fusion experiments.

  9. Single crystal diamond detector measurements of deuterium-deuterium and deuterium-tritium neutrons in Joint European Torus fusion plasmas

    SciTech Connect

    Cazzaniga, C. Gorini, G.; Nocente, M.; Sundén, E. Andersson; Binda, F.; Ericsson, G.; Croci, G.; Grosso, G.; Cippo, E. Perelli; Tardocchi, M.; Giacomelli, L.; Rebai, M.; Griesmayer, E.; Kaveney, G.; Syme, B.; Collaboration: JET-EFDA Contributors

    2014-04-15

    First simultaneous measurements of deuterium-deuterium (DD) and deuterium-tritium neutrons from deuterium plasmas using a Single crystal Diamond Detector are presented in this paper. The measurements were performed at JET with a dedicated electronic chain that combined high count rate capabilities and high energy resolution. The deposited energy spectrum from DD neutrons was successfully reproduced by means of Monte Carlo calculations of the detector response function and simulations of neutron emission from the plasma, including background contributions. The reported results are of relevance for the development of compact neutron detectors with spectroscopy capabilities for installation in camera systems of present and future high power fusion experiments.

  10. Response of single benthic metrics and multi-metric methods to anthropogenic pressure gradients, in five distinct European coastal and transitional ecosystems.

    PubMed

    Borja, Angel; Barbone, Enrico; Basset, Alberto; Borgersen, Gunhild; Brkljacic, Marijana; Elliott, Michael; Garmendia, Joxe Mikel; Marques, João Carlos; Mazik, Krysia; Muxika, Iñigo; Magalhães Neto, João; Norling, Karl; Rodríguez, J Germán; Rosati, Ilaria; Rygg, Brage; Teixeira, Heliana; Trayanova, Antoaneta

    2011-03-01

    In recent times many benthic indices have been proposed to assess the ecological quality of marine waters worldwide. In this study we compared single metrics and multi-metric methods to assess coastal and transitional benthic status along human pressure gradients in five distinct environments across Europe: Varna bay and lake (Bulgaria), Lesina lagoon (Italy), Mondego estuary (Portugal), Basque coast (Spain) and Oslofjord (Norway). Hence, 13 single metrics (abundance, number of taxa, and several diversity and sensitivity indices) and eight of the most common indices used within the European Water Framework Directive (WFD) for benthic assessment were selected: index of size spectra (ISS), Benthic assessment tool (BAT), Norwegian quality index (NQI), Multivariate AMBI (M-AMBI), Benthic quality index (BQI), (Benthic ecosystem quality index (BEQI), Benthic index based on taxonomic sufficiency (BITS), and infaunal quality index (IQI). Within each system, sampling sites were ordered in an increasing pressure gradient according to a preliminary classification based on professional judgement. The different indices are largely consistent in their response to pressure gradient, except in some particular cases (i.e. BITS, in all cases, or ISS when a low number of individuals is present). Inconsistencies between indicator responses were most pronounced in transitional waters (i.e. IQI, BEQI), highlighting the difficulties of the generic application of indicators to all marine, estuarine and lagoonal environments. However, some of the single (i.e. ecological groups approach, diversity, richness) and multi-metric methods (i.e. BAT, M-AMBI, NQI) were able to detect such gradients both in transitional and coastal environments, being these multi-metric methods more consistent in the detection than single indices. This study highlights the importance of survey design and good reference conditions for some indicators. The agreement observed between different methodologies and their

  11. EGFR mutation testing on cytological and histological samples in non-small cell lung cancer: a Polish, single institution study and systematic review of European incidence.

    PubMed

    Szumera-Ciećkiewicz, Anna; Olszewski, Włodzimierz T; Tysarowski, Andrzej; Kowalski, Dariusz M; Głogowski, Maciej; Krzakowski, Maciej; Siedlecki, Janusz A; Wągrodzki, Michał; Prochorec-Sobieszek, Monika

    2013-01-01

    The targeted treatment of advanced non-small-cell lung cancer (NSCLC) depends on confirmation of activating somatic EGFR mutation. The aim of the study was to evaluate the incidence of EGFR mutations in NSCLC detected in cytological and histological material and present literature review on European EGFR mutation incidence. 273 patients with confirmed NSCLC were entered into the study: 189 histological, paraffin-embedded materials, 12 fresh and 72 fixed cytological specimens. DNA was extracted from both types of material and the EGFR mutation in exons 18-21 was analyzed by direct sequencing. In addition the EGFR gene copy number in cases with sufficient histological material (110 patients) was evaluated by fluorescent in situ hybridization (FISH) technique. The percentage of EGFR somatic mutations was 10.62%. FISH positive results (amplification or high polysomy of EGFR gene) were identified in 33 patients (30.0%). The strongest clinicopathological correlation with the EGFR mutation was found for histological type (adenocarcinoma; p < 0.01), gender (females; p < 0.01) and FISH positive result (p < 0.05). This is the first, single institution study that estimates the EGFR mutation incidence in the Polish population. Cytological material recovered from fixed preparations and stained with hematoxylin and eosin showed DNA quality comparable to fresh tumor cells and histological samples.

  12. A resource of genome-wide single-nucleotide polymorphisms generated by RAD tag sequencing in the critically endangered European eel.

    PubMed

    Pujolar, J M; Jacobsen, M W; Frydenberg, J; Als, T D; Larsen, P F; Maes, G E; Zane, L; Jian, J B; Cheng, L; Hansen, M M

    2013-07-01

    Reduced representation genome sequencing such as restriction-site-associated DNA (RAD) sequencing is finding increased use to identify and genotype large numbers of single-nucleotide polymorphisms (SNPs) in model and nonmodel species. We generated a unique resource of novel SNP markers for the European eel using the RAD sequencing approach that was simultaneously identified and scored in a genome-wide scan of 30 individuals. Whereas genomic resources are increasingly becoming available for this species, including the recent release of a draft genome, no genome-wide set of SNP markers was available until now. The generated SNPs were widely distributed across the eel genome, aligning to 4779 different contigs and 19,703 different scaffolds. Significant variation was identified, with an average nucleotide diversity of 0.00529 across individuals. Results varied widely across the genome, ranging from 0.00048 to 0.00737 per locus. Based on the average nucleotide diversity across all loci, long-term effective population size was estimated to range between 132,000 and 1,320,000, which is much higher than previous estimates based on microsatellite loci. The generated SNP resource consisting of 82,425 loci and 376,918 associated SNPs provides a valuable tool for future population genetics and genomics studies and allows for targeting specific genes and particularly interesting regions of the eel genome.

  13. Single dose cabergoline versus bromocriptine in inhibition of puerperal lactation: randomised, double blind, multicentre study. European Multicentre Study Group for Cabergoline in Lactation Inhibition.

    PubMed Central

    1991-01-01

    OBJECTIVE--To compare the efficacy and safety of a single dose of 1 mg of cabergoline with that of bromocriptine 2.5 mg twice daily for 14 days in the inhibition of puerperal lactation. DESIGN--Prospective, randomised, double blind, parallel group, multicentre study. SETTING--University of hospital departments of obstetrics and gynaecology in different European countries. SUBJECTS--272 puerperal women not wishing to lactate (136 randomised to each drug). INTERVENTIONS--Women randomised to cabergoline received two 0.5 mg tablets of cabergoline and one placebo tablet within 27 hours after delivery and then placebo twice daily for 14 days. Those randomised to bromocriptine received 2.5 mg of bromocriptine and two placebo tablets within 27 hours and then 2.5 mg of bromocriptine twice daily for 14 days. MAIN OUTCOME MEASURES--Success of treatment (complete or partial) according to milk secretion, breast engorgement, and breast pain; rebound symptomatology; serum prolactin concentrations; and number of adverse events. RESULTS--Complete success was achieved in 106 of 136 women randomised to cabergoline and in 94 of 136 randomised to bromocriptine and partial success in 21 and 33 women respectively. Rebound breast symptomatology occurred respectively in five and 23 women with complete success up to day 15 (p less than 0.0001). Serum prolactin concentrations dropped considerably with both drugs from day 2 to day 15; a prolactin secretion rebound effect was observed in women treated with bromocriptine. cabergoline and 36 receiving bromocriptine (p = 0.054), occurring most during the first treatment day. CONCLUSION--A single 1 mg dose of cabergoline is at least as effective as bromocriptine 2.5 mg twice daily for 14 days in preventing puerperal lactation. Because of the considerably lower rate of rebound breast activity and adverse events and the simpler administration schedule cabergoline should be the drug of choice for lactation inhibition. PMID:1676318

  14. Historical market data

    SciTech Connect

    1996-08-01

    Historical financial data is provided for the uranium market in graphic and tabular form. Market data includes restricted and unrestricted uranium price ranges; exchange, transaction, uranium hexafluoride, conversion, and separative work values; and annual world uranium production and requirements. Selected historical economic indicators are listed for Australia, Canada, South Africa, and the United States. Natural uranium deliveries to the European Union and U.S. uranium marketing data are provided.

  15. 75 FR 11553 - Final Fair Market Rents for the Housing Choice Voucher Program and Moderate Rehabilitation Single...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... for the following FMR areas: Reno-Sparks, NV Metropolitan Statistical Area (MSA), and Ward County, ND... by Number of Bedrooms in Unit 2010 Fair Market Rent Area 0 BR 1 BR 2 BR 3 BR 4 BR Reno-Sparks, NV...

  16. 78 FR 25295 - Final Fair Market Rents for the Housing Choice Voucher Program and Moderate Rehabilitation Single...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ..., based on surveys conducted in September 2012 and for Burlington, VT, Mountrail County, ND, Ward County... following areas: Cheyenne, WY, and Odessa, TX, Burlington-South Burlington, VT and a three-county group in... market rent area 0 BR 1 BR 2 BR 3 BR 4 BR Burlington-South Burlington, VT MSA 902 980 1280 1604...

  17. Quality evaluation of medicinal products and health foods containing chaste berry (Vitex agnus-castus) in Japanese, European and American markets.

    PubMed

    Fukahori, Masahiro; Kobayashi, Shojiro; Naraki, Yoko; Sasaki, Takahiro; Oka, Hideki; Seki, Masaharu; Masada-Atsumi, Sayaka; Hakamatsuka, Takashi; Goda, Yukihiro

    2014-01-01

    The aim of present study was to evaluate the qualities of chaste berry (fruit of Vitex agnus-castus L.) preparations using HPLC fingerprint analysis. Seven medicinal products 1 from Japan and 6 from Europe, and 17 health foods, 6 from Japan and 11 from the United States were analyzed. HPLC profile and 26 authentic peaks were compared medicinal products and health foods. Whereas medicinal products had similar HPLC profiles, health foods had various profiles and each peak was also greatly different. The measured amounts of two markers in 5 traditional medicinal products, agnuside and casticin specified in the European Pharmacopoeia (EP), the U.S. Pharmacopoeia (USP) or the WHO monographs of chaste berry, were much lower than those in 2 medicinal products defined as "well-established use" by the European Medicines Agency. The amounts of two markers for 17 health foods differed in a great deal from 14-5054% and 3-1272%, respectively. Furthermore the amount ratios of two markers, agnuside/casticin, in about half of the health foods were remarkably larger than the standard crude drug and the ratios were closer to one of the related Chinese herbs, Vitex negundo L. It is concluded that a combination of HPLC fingerprints and the amount ratios of the marker compounds of chaste berry preparations serves as a useful tool to evaluate the qualities of these preparations.

  18. Biophotonics: a European perspective

    NASA Astrophysics Data System (ADS)

    Robin, Thierry; Cochard, Jacques; Breussin, Frédéric

    2013-03-01

    The objective of the present work is to determine the opportunities and challenges for Biophotonics business development in Europe for the next five years with a focus on sensors and systems: for health diagnostics and monitoring; for air, water and food safety and quality control. The development of this roadmap was initiated and supported by EPIC (The European Photonics Industry Consortium). We summarize the final roadmap data: market application segments and trends, analysis of the market access criteria, analysis of the technology trends and major bottlenecks and challenges per application.

  19. Pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam in healthy volunteers: an interethnic comparative study between Japanese and European volunteers.

    PubMed

    van Gerven, J M; Uchida, E; Uchida, N; Pieters, M S; Meinders, A J; Schoemaker, R C; Nanhekhan, L V; Kroon, J M; de Visser, S J; Altorf, B; Yasuda, K; Yasuhara, H; Cohen, A F

    1998-12-01

    Potential interethnic differences in drug disposition and effects between Japanese and white subjects hamper the registration in Japan of medications already used in Western countries. This double-blind, placebo-controlled, crossover study was conducted to compare the pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam (5 mg) in age- and sex-matched Japanese (n = 8) and white (n = 8) healthy volunteers. The study was performed in centers in Japan and the Netherlands using the same methods and study design. Subjects were individually matched for gender, age, and body stature. Drug effects were measured by means of saccadic and smooth pursuit eye movements and visual analog lines obtained from the scales of Bond and Lader. There were no pharmacokinetic differences between the Japanese and white subjects. Clearance of nitrazepam was 0.91 +/- 0.165 mL/min/kg and 1.17 +/- 0.492 mL/min/kg, and half-life (t1/2) was 22.1 +/- 4.96 hours and 21.5 +/- 7.51 hours for the Japanese and European groups, respectively. Pharmacokinetic parameters showed no significant correlation with age, height, or weight. The average time-effect curves for the different parameters were comparable between groups. Compared with placebo, both groups showed similar significant reductions in average peak velocity and increases in saccadic inaccuracy and reaction time. Visual analog scores showed clear sedation in the white subjects, but insignificant effects in the Japanese subjects. Smooth pursuit did not change significantly in either group. Slope and intercept of the concentration-effect relationships for saccadic peak velocity showed considerable intersubject variability, but no clear differences between groups. The pharmacokinetics and pharmacodynamics of nitrazepam were similar in matched healthy Japanese and white subjects. Interethnic comparative studies are feasible, and provide meaningful information about potential racial differences in disposition and action of drugs

  20. 1996-2004 Trends in the Single-Family Housing Market: Spatial Analysis of the Residential Sector

    SciTech Connect

    Anderson, Dave M.; Elliott, Douglas B.

    2006-09-05

    This report provides a detailed geographic analysis of two specific topics affecting the residential sector. First, we performed an analysis of new construction market trends using annual building permit data. We report summarized tables and national maps to help illustrate market conditions. Second, we performed a detailed geographic analysis of the housing finance market. We analyzed mortgage application data to provide citable statistics and detailed geographic summarization of the residential housing picture in the US for each year in the 1996-2004 period. The databases were linked to geographic information system tools to provide various map series detailing the results geographically. Looking at these results geographically may suggest potential new markets for TD programs addressing the residential sector that have not been considered previously. For example, we show which lenders affect which regions and which income or mortgage product classes. These results also highlight the issue of housing affordability. Energy efficiency R&D programs focused on developing new technology for the residential sector must be conscious of the costs of products resulting from research that will eventually impact the home owner or new home buyer. Results indicate that home values as a proportion of median family income in Building America communities are closely aligned with the national average of home value as a proportion of median income. Other key findings: • The share of home building and home buying activity continues to rise steadily in the Hot-Dry and Hot-Humid climate zones, while the Mixed-Humid and Cold climate zone shares continue to decline. Other zones remain relatively stable in terms of share of housing activity. • The proportion of home buyers having three times the median family income for their geography has been steadily increasing during the study period. • Growth in the Hispanic/Latino population and to a lesser degree in the Asian population has

  1. World helicopter market study

    NASA Technical Reports Server (NTRS)

    Cleary, B.; Pearson, R. W.; Greenwood, S. W.; Kaplan, L.

    1978-01-01

    The extent of the threat to the US helicopter industry posed by a determined effort by foreign manufacturers, European companies in particular, to supply their own domestic markets and also to penetrate export markets, including the USA is assessed. Available data on US and world markets for civil and military uses are collated and presented in both graphic and tabular form showing the past history of production and markets and, where forecasts are available, anticipated future trends. The data are discussed on an item-by-item basis and inferences are drawn in as much depth as appears justified.

  2. Assessment of dietary exposure to flavouring substances via consumption of flavoured teas. Part 1: occurrence and contents of monoterpenes in Earl Grey teas marketed in the European Union.

    PubMed

    Orth, Anne-Marie; Yu, Lu; Engel, Karl-Heinz

    2013-01-01

    Estimations of dietary exposure via the consumption of flavoured foods play a central role in the safety evaluation of flavouring substances. To assess uncertainties, actual data regarding the occurrence and concentration levels of flavouring substances were determined in commercially available flavoured foods, using Earl Grey tea as an example. The contents of the consistently occurring monoterpenes linalyl acetate, linalool, limonene, β-pinene and γ-terpinene were determined in 90 tea samples purchased in 10 European Union member states. Rather narrow frequency distributions were observed for the major compounds linalyl acetate and linalool. The factors (1) country of purchase, (2) source of the products (national/international brands versus private label brands versus speciality tea shops), and (3) enantiomeric purities of the flavouring substances had no significant impact on the contents of the flavouring substances. Only in teas sold as loose leaves were the median contents of linalyl acetate and linalool (66% and 39%, respectively) higher than in teas offered in tea bags. Significant losses of flavouring substances were observed on storage of teas, indicating an impact of the type of packaging and the flavouring technology on the contents of flavouring substances in the product finally consumed.

  3. Harmonization of European neurology education: the junior doctor's perspective.

    PubMed

    Macerollo, Antonella; Struhal, Walter; Sellner, Johann

    2013-10-29

    The objective of this article, written by executives of the European Association of Young Neurologists and Trainees (EAYNT), is to illustrate the status quo of neurology training in Europe and give an outlook on ongoing efforts and prospects for junior neurologists. The European Union is an economic and political union that currently encompasses 27 member states with more than 500 million inhabitants (or 7.3% of the world population) (interested readers are referred to http://en.wikipedia.org/wiki/European_Union). Countries of the European Union act as a single market with free movement of citizens, goods, services, and finances. As a consequence, a diploma and postgraduate training obtained in one EU country will be automatically recognized by all other EU member states. At the Lisbon European Council in March 2000, the Heads of State or Government signed a treaty that expresses their ambition of making Europe "the most competitive and dynamic knowledge-based economy in the world, capable of sustainable economic growth with more and better jobs and greater social cohesion" (www.en.wikipedia.org/wiki/Lisbon_Strategy). More than 1.6 million physicians in all the different medical specialties are represented by the European Union of Medical Specialists (UEMS). The UEMS was founded in 1958 and the objectives include the study, promotion, and harmonization of the highest level of training of medical specialists, medical practice, and health care within the European Union. The European Board of Neurology (UEMS-EBN; www.uems-neuroboard.org) is in charge of the implementation of the UEMS policy regarding neurology.

  4. New Testing Standard For European Programs

    NASA Astrophysics Data System (ADS)

    Giordano, P.

    2004-08-01

    Standardization is a key aspect of the production business committed to the optimization of the product development and cost. In the Space field, American industries and Government organizations have developed since several decades Space standards like the MIL series, deriving them from the aircraft and military fields, or the NASA standards. The same happened later in other countries like Russia, Japan and China. In the last years most of those standards were revised to cope with the emerging needs of the market. In Europe, the Space activities were generally managed by a set of ESA standards, the PSS, which covered some aspects of these activities and reflected the up-to-date approaches and common practices. But, in the last years an initiative was also promoted by ESA, National Agencies and Space Organizations, named ECSS (European Cooperation for Space Standardization), with the aim to develop a coherent, single set of user-friendly standards for use in all European space activities. European industries supported this initiative, including a deep involvement of Alenia Spazio and, sometime through a suitable revision of the old PSS documents, new standards were defined, as for the "Testing" (ECSS-E-10-03A, now published). The ECSS-E-10-03A provides standard environmental and performance test requirements for space products (systems and their constituents) which are generally applicable to all projects. Scope of this paper is to present the status of the worldwide initiatives in the testing standardization, the major contents of the European ECSS Testing standard and the possibilities for tailoring. Differences in requirement definition with other international testing standards and proposals for further ECSS optimization are presented on the basis of Alenia Spazio experience in supporting the above initiatives.

  5. Optranet: a European project

    NASA Astrophysics Data System (ADS)

    Jeanjean, Marie

    2003-10-01

    In a situation where curricula did not adjust at the required pace and many students are getting attracted out of science and technology, the shortage of skilled workers at the technician and engineer level is known to be a threat to development. In spite of a serious crisis in 2001, the trend of an increased presence of optical technologies remains unchanged and is bound to remain part of the landscape for decades. The level of investment required and the markets make Europe the best scale to plan for unified curricula and a global analysis of the human resources needs. There is no agreement on the definition of a trained optician, and European countries differ in the way they educate opticians, source of a lack of clarity and visibility which is detrimental to attracting good students and to the job market. Through its closely work with companies, OPTRANET will propose measures to enhance the adequacy and the visibility of the training offer.

  6. Market review - Market values summary/October market review/current market data

    SciTech Connect

    1995-11-01

    This article is the October 1995 uranium market summary. In this reporting period, there were four transactions in the natural uranium market, no activity in the spot UF6 market, no activity in the spot conversion market, and only a single activity in the enrichment services market. Spot uranium volume dropped sharply, and active uranium supply rose. The rise in demand, however, more than offset this increase. Unrestricted exchange prices rose slightly, as did the unrestricted UF6 value. All other prices remained steady.

  7. ERASMUS: European Community Program for the Development of Student Mobility in the European Community.

    ERIC Educational Resources Information Center

    European Education, 1991

    1991-01-01

    Describes the European Community's efforts to unify Europe and enhance competitiveness in world markets by improving use of available intellectual potential. Discusses ERASMUS, the European Community Action Scheme for the Mobility of University Students. Explains the role of Inter-University Cooperation Programs (ICPs), a course credit transfer…

  8. Livestock Marketing.

    ERIC Educational Resources Information Center

    Futrell, Gene; And Others

    This marketing unit focuses on the seasonal and cyclical patterns of livestock markets. Cash marketing, forward contracting, hedging in the futures markets, and the options markets are examined. Examples illustrate how each marketing tool may be useful in gaining a profit on livestock and cutting risk exposure. The unit is organized in the…

  9. Current european regulatory perspectives on insulin analogues

    PubMed Central

    2011-01-01

    Insulin analogues are increasingly considered as an alternative to human insulin in the therapy of diabetes mellitus. Insulin analogues (IAs) are chemically different from human insulin and may have different pharmacokinetic or pharmacodynamic properties. The significance of the modifications of the insulin molecule for the safety profile of IAs must be considered. This review describes the regulatory procedure and the expectations for the scientific content of European marketing authorization applications for innovative IAs submitted to the European Medicines Agency. Particular consideration is given to a potential cancer hazard. Specific regulatory guidance on how to address a possible carcinogenic or tumor promoting effect of innovative IAs in non-clinical studies is available. After marketing authorization, the factual access of patients to the new product will be determined to great extent by health technology assessment bodies, reimbursement decisions and the price. Whereas the marketing authorization is a European decision, pricing and reimbursement are national or regional responsibilities. The assessment of benefit and risk by the European Medicines Agency is expected to influence future decisions on price and reimbursement on a national or regional level. Collaborations between regulatory agencies and health technology assessment bodies have been initiated on European and national level to facilitate the use of the European Medicines Agency's benefit risk assessment as basis on which to build the subsequent health technology assessment. The option for combined or joint scientific advice procedures with regulators and health technology assessment bodies on European level or on a national level in several European Member States may help applicants to optimize their development program and dossier preparation in regard of both European marketing authorization application and reimbursement decisions. PMID:21736748

  10. The reorganisation of European pharmacovigilance. Part 2. From spontaneous reports to agency reviews and decisions.

    PubMed

    2015-02-01

    Despite the fact that adverse effects are vastly under-reported, spontaneous reporting remains the foundation of pharmacovigilance. A small series of properly documented cases, when very specific, can suffice to constitute a signal. In France, reporting adverse effects to Regional Pharmacovigilance Centres (CRPVs) permits high-quality analysis of pharmacovigilance signals, so that they can be brought to the attention of the national agency responsible for making decisions about drugs, the French Health Products Agency (ANSM). The ANSM can use this information to protect patients by implementing the measures within its power or by initiating a European referral. When a decision taken at the national level concerns a drug marketed in several Member States of the European Union, a "harmonisation" procedure results in a decision taken at community level, applicable in all Member States. This means that a safety issue raised by a single Member State sometimes leads to a decision that protects the population of the entire European Union. But it also means that other European decisions can compel national agencies to allow back onto the market a drug that they sought to withdraw in order to protect their citizens. Negotiations with other Member States, the European Medicines Agency (EMA) and the European Commission must be supported by robust data: this is yet another reason for each country to have its own effective national pharmacovigilance database, the contents of which should be publicly accessible. This is unfortunately not yet the case in France in 2014. It also provides another good reason for healthcare professionals and patients to report adverse effects, so that the details can be recorded in national and European databases.

  11. Optical design of the single-detector planetary stereo camera for the BepiColombo European Space Agency mission to Mercury.

    PubMed

    Da Deppo, Vania; Naletto, Giampiero; Cremonese, Gabriele; Calamai, Luciano

    2010-05-20

    We present the catadioptric optical design solution for the stereo channel of the imaging system SIMBIOSYS for the BepiColombo European Space Agency mission to Mercury. The main scientific objectives of the instrument are the three-dimensional global mapping of the entire surface of Mercury in the panchromatic band and imaging of selected areas in four broad colored bands; both tasks have to be accomplished with a scale factor of 50?m per pixel at periherm. The system consists of an original compact layout in which the two stereo subchannels share a common detector; also, the optical components are common to the two subchannels, with the exception of the first element, which is a rhomboid prism. The field of view of each subchannel is about 5 degrees x5 degrees with a scale factor of 23 arcsec/pixel. The ray-tracing simulation of the system shows that the design guarantees optimal aberration balancing over the entire field of view and the entire wavelength range covered by the instrument, with ensquared energy of the order of 80% in one pixel.

  12. The European race of Gremmeniella abietina hosts a single species of Gammapartitivirus showing a global distribution and possible recombinant events in its history.

    PubMed

    Botella, Leticia; Tuomivirta, Tero T; Hantula, Jarkko; Diez, Julio J; Jankovsky, Libor

    2015-03-01

    The population genetics of the family Partitiviridae was studied within the European race of the conifer pathogen Gremmeniella abietina. One hundred sixty-two isolates were collected from different countries, including Canada, the Czech Republic, Finland, Italy, Montenegro, Serbia, Spain, Switzerland, Turkey and the United States. A unique species of G. abietina RNA virus-MS1 (GaRV-MS1) appears to occur indistinctly in G. abietina biotypes A and B, without a particular geographical distribution pattern. Forty-six isolates were shown to host GaRV-MS1 according to direct specific RT-PCR screening, and the virus was more common in biotype A than B. Phylogenetic analysis based on 46 partial coat protein (CP) cDNA sequences divided the GaRV-MS1 population into two closely related clades, while RNA-dependent RNA polymerase (RdRp) sequences revealed only one clade. The evolution of the virus appears to mainly occur through purifying selection but also through recombination. Recombination events were detected within alignments of the three complete CP and RdRp sequences of GaRV-MS1. This is the first time that recombination events have been directly identified in fungal partitiviruses and in G. abietina in particular. The results suggest that the population dynamics of GaRV-MS1 do not have a direct impact on the genetic structure of its host, G. abietina, though they might have had an innocuous ancestral relationship.

  13. The European Society for Medical Oncology Magnitude of Clinical Benefit Scale in daily practice: a single institution, real-life experience at the Medical University of Vienna

    PubMed Central

    Kiesewetter, Barbara; Raderer, Markus; Steger, Günther G; Bartsch, Rupert; Pirker, Robert; Zöchbauer-Müller, Sabine; Prager, Gerald; Krainer, Michael; Preusser, Matthias; Schmidinger, Manuela; Zielinski, Christoph C

    2016-01-01

    Background The European Society for Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale (MCBS) has been designed to stratify the therapeutic benefit of a certain drug registered for the treatment of cancer. However, though internally validated, this tool has not yet been evaluated for its feasibility in the daily practice of a major center of medical oncology. Methods The practicability of the MCBS for advanced oncological diseases at the Clinical Division of Oncology, Medical University of Vienna, which constitutes one of the largest oncological centres in Europe, was analysed in a three-step approach. First, retrospectively collected data were analysed to gain an overview of treatments in regular use. Second, data were scored by using the MCBS. Third, the ensuing results were evaluated within corresponding programme directorships to assess feasibility in a real-life clinical context. Results In the majority of tumour entities, the MCBS results reported earlier are consistent with daily clinical practice. Thus, in metastatic breast cancer or advanced lung cancer, there was a high level of clinical benefit for first-line treatment standards, and these results reflected well real-life experience. However, analyses based on the first version of the MCBS are limited if it comes to salvage treatment in tumour entities in which optimal sequencing of potential treatment options is of major importance, as in metastatic colorectal or renal cell cancer. In contrast to this, it is remarkable that certain novel therapies such as nivolumab assessed for heavily pretreated advanced renal cancer reached the highest level of clinical benefit due to prolongation in survival and a favourable toxicity profile. The MCBS clearly underlines the potential benefit of these compounds. Conclusions The MCBS is an excellent tool for daily clinical practice of a tertiary referral centre. It supports treatment decisions based on the clinical benefit to be expected from a novel approach

  14. European packaging laws: Can it happen here?

    SciTech Connect

    Rogers, B.

    1996-06-01

    European packaging recycling and reduction efforts helped reshape recycling efforts and thinking. This article provides an update on what is happening with packaging recycling in Europe and how it affects the rest of the world, especially the US. World recycling markets were shaken by the enactment of the German Packaging Recycling ordinance of 1991. While the initial market shock waves may have subsided, the effects are still being felt. The ordinance has changed the way European countries think about packaging waste, and that way of thinking has spread, in various forms, around the world, affecting US manufacturers and causing US lawmakers to at least consider similar legislation here. The German Packaging Ordinance, its counterparts in other countries, and the European Union (EU) Directive have, themselves, been evolutionary as well as revolutionary--reacting and changing over the past five years. US reaction to the European laws has also evolved, moving from horror and annoyance to a reasoned analysis and evaluation.

  15. Natural gas demand surges among European customers

    SciTech Connect

    Knott, D.

    1993-12-27

    Europe's view of natural gas as a clean fuel is driving demand faster than European producers can supply the fuel. By 2010 European gas demand is expected to rise by 50%, so imports will need to rise in step. There are plenty of gas reserves within and in reach of the European market to meet increasing needs. But current low gas prices in Europe are a barrier to development of gas projects, which are large, long term investments. Meanwhile, the structure of Europe and its gas markets is changing. There is a trend to privatization and uncertainty over the future role of state gas monopolies. The paper discusses European production, natural gas as a primary energy source, gas sources, price requirements, megaprojects, the Middle East promise, new infrastructure, power generation, privatization, and third party access.

  16. Africa; Expanding market creates more gas lines

    SciTech Connect

    Quarles, W.R.; Thiede, K.; Parent, L.

    1990-11-01

    The authors report on pipeline development activities in Africa. They discuss how a growing European market for gas has increased potential pipeline construction in Africa, especially for Algeria, Egypt, and Libya.

  17. Fast ion energy distribution from third harmonic radio frequency heating measured with a single crystal diamond detector at the Joint European Torus

    SciTech Connect

    Nocente, M.; Rebai, M.; Gorini, G.; Cazzaniga, C.; Tardocchi, M.; Giacomelli, L.; Muraro, A.; Binda, F.; Eriksson, J.; Sharapov, S.; Collaboration:

    2015-10-15

    Neutron spectroscopy measurements with a single crystal diamond detector have been carried out at JET, for the first time in an experiment aimed at accelerating deuterons to MeV energies with radio frequency heating at the third harmonic. Data are interpreted by means of the expected response function of the detector and are used to extract parameters of the highly non-Maxwellian distribution function generated in this scenario. A comparison with observations using a time of flight and liquid scintillator neutron spectrometers is also presented. The results demonstrate the capability of diamond detectors to contribute to fast ion physics studies at JET and are of more general relevance in view of the application of such detectors for spectroscopy measurements in the neutron camera of next step tokamak devices.

  18. The European and Japanese outbreaks of H5N8 derive from a single source population providing evidence for the dispersal along the long distance bird migratory flyways

    PubMed Central

    Iqbal, Munir

    2015-01-01

    The origin of recent parallel outbreaks of the high pathogenicity H5N8 avian flu virus in Europe and in Japan can be traced to a single source population, which has most likely been spread by migratory birds. By using Bayesian coalescent methods to analyze the DNA sequences of the virus to find the times for divergence and combining this sequence data with bird migration data we can show the most likely locations and migratory pathways involved in the origin of the current outbreak. This population was most likely located in the Siberian summer breeding grounds of long-range migratory birds. These breeding grounds provide a connection between different migratory flyways and explain the current outbreaks in remote locations. By combining genetic methods and epidemiological data we can rapidly identify the sources and the dispersion pathways for novel avian influenza outbreaks. PMID:25945320

  19. Childcare Markets in an Age of Austerity

    ERIC Educational Resources Information Center

    Lloyd, Eva; Penn, Helen

    2014-01-01

    Public support provided for European early childhood education and care (ECEC) systems varies considerably. European ECEC systems tend to form part of a mixed economy, in which the state, private-for-profit and private-not-for-profit providers all play a role in ECEC's provision, funding and regulation, representing a market model. ECEC…

  20. Induction of spermatogenesis and spermiation by a single injection of human chorionic gonadotropin in intact and hypophysectomized immature European eel (Anguilla anguilla L.).

    PubMed

    Khan, I A; Lopez, E; Leloup-Hâtey, J

    1987-10-01

    Intact and hypophysectomized male silver eels (Anguilla anguilla) in fresh water received a single injection of human chorionic gonadotropin (hCG) (250 C) or solvent (0.15 M NaCl). No effect of solvent was observed. Spermatogonia proliferated in testis of hCG-treated intact or hypophysectomized eels. One month after the injection, primary and secondary spermatocytes were found. After 3 months, numerous spermatozoa were present. In hypophysectomized eels, hCG was also effective even though maturing germ cells were less numerous and spermiation was less frequent than in intact animals. Within 1 week after hCG injection, plasma levels of free and glucuroconjugated androgens (testosterone and 11-oxotestosterone) rose significantly in intact and hypophysectomized fish. The highest values were observed within 1 month, and then plasma levels decreased to pretreatment values. The most important changes were observed in the case of free 11-oxotestosterone. The long-term effects of hCG can be explained partly by the long half-life of this hormone. The effects of hypophysectomy on the response of testis to hCG caused us to think that some endogenous pituitary secretions must interfere in the intact fish so that maximal effects of hCG, especially on the induction of spermiation, are obtained.

  1. Older Workers in the European Community, Japan, and Canada.

    ERIC Educational Resources Information Center

    Drury, Elizabeth; And Others

    1993-01-01

    Includes "Older Workers in the European Community: Pervasive Discrimination, Little Awareness" (Drury); "Aging Workers in Japan: From Reverence to Redundance" (Takada); and "Canada's Labor Market: Older Workers Need Not Apply" (David). (JOW)

  2. Hospital marketing.

    PubMed

    Carter, Tony

    2003-01-01

    This article looks at a prescribed academic framework for various criteria that serve as a checklist for marketing performance that can be applied to hospital marketing organizations. These guidelines are drawn from some of Dr. Noel Capon of Columbia University's book Marketing Management in the 21st Century and applied to actual practices of hospital marketing organizations. In many ways this checklist can act as a "marketing" balanced scorecard to verify performance effectiveness and develop opportunities for innovation.

  3. Cigarettes, genetic background, and menopausal timing: the presence of single nucleotide polymorphisms in cytochrome P450 genes is associated with increased risk of natural menopause in European-American smokers

    PubMed Central

    Butts, Samantha F.; Sammel, Mary D.; Greer, Christine; Rebbeck, Timothy R.; Boorman, David W.; Freeman, Ellen W.

    2016-01-01

    Objective This study aims to evaluate associations between variations in genes involved in the metabolism of environmental chemicals and steroid hormones and risk of menopause in smokers. Methods Survival analysis was performed on 410 eligible participants from the Penn Ovarian Aging study (ongoing for 14 years), a cohort study of late-reproductive-age women. Single nucleotide polymorphisms at the following loci were studied: COMT Val158Met, CYP1B1*4 Asn452Ser, CYP1B1*3 Leu432Val, and CYP3A4*1B. Results Significant interactions between smoking and single nucleotide polymorphisms were observed in European-American carriers of CYP3A4*1B and CYP1B1*3, supporting a greater risk of menopause entry compared with those not carrying these alleles. Among CYP1B1*3 carriers, smokers had a greater risk of menopause entry than nonsmokers (adjusted hazard ratio [HR], 2.26; 95% CI, 1.4–3.67; median time to menopause, 10.42 and 11.07 y, respectively). No association between smoking and menopause was identified in CYP1B1 wild types. Among CYP3A4*1B carriers, smokers were at greater risk for menopause entry than nonsmokers (adjusted HR, 15.1; 95% CI, 3.31–69.2; median time to menopause, 11.36 and 13.91 y, respectively). Risk of menopause entry in CYP3A4 wild types who smoked was far lower (adjusted HR, 1.59; 95% CI, 1.03–2.44). Heavily smoking CYP1B1*3 carriers (adjusted HR, 3.0; 95% CI, 1.54–5.84; median time to menopause, 10.41 y) and heavily smoking CYP3A4*1B carriers (adjusted HR, 17.79; 95% CI, 3.21–98.65; median time to menopause, 5.09 y) had the greatest risk of menopause entry. Conclusions Our finding that the risk of menopause entry in European-American smokers varies depending on genetic background represents a novel gene-environment interaction in reproductive aging. PMID:24448104

  4. Aerosol properties, source identification, and cloud processing in orographic clouds measured by single particle mass spectrometry on a Central European mountain site during HCCT-2010

    NASA Astrophysics Data System (ADS)

    Roth, A.; Schneider, J.; Klimach, T.; Mertes, S.; van Pinxteren, D.; Herrmann, H.; Borrmann, S.

    2015-09-01

    Cloud residues and out-of-cloud aerosol particles with diameters between 150 and 900 nm have been analysed by on-line single particle aerosol mass spectrometry during the six-week study HCCT-2010 in September/October 2010. The measurement location was the mountain Schmücke (937 m a.s.l.) in Central Germany. More than 170 000 bipolar mass spectra from out-of-cloud aerosol particles and more than 14 000 bipolar mass spectra from cloud residual particles were obtained and were classified using a fuzzy c-means clustering algorithm. Analysis of the uncertainty of the sorting algorithm was conducted on a subset of the data by comparing the clustering output with particle-by-particle inspection and classification by the operator. This analysis yielded a false classification probability between 13 and 48 %. Additionally, particle types were identified by specific marker ions. The results from the ambient aerosol analysis show that 63 % of the analysed particles belong to clusters indicating a diurnal variation, suggesting that local or regional sources dominate the aerosol, especially for particles containing soot and biomass burning particles. In the cloud residues the relative percentage of large soot-containing particles and particles containing amines was found to be increased compared to the out-of-cloud aerosol, while in general organic particles were less abundant in the cloud residues. In the case of amines this can be explained by the high solubility of the amines, while the large soot-containing particles were found to be internally mixed with inorganics, which explains their activation as cloud condensation nuclei. Furthermore, the results show that during cloud processing, both sulphate and nitrate are added to the residual particles, thereby changing the mixing state and increasing the fraction of particles with nitrate and/or sulphate. This is expected to lead to higher hygroscopicity after cloud evaporation, and therefore to an increase of the particles

  5. Aerosol properties, source identification, and cloud processing in orographic clouds measured by single particle mass spectrometry on a central European mountain site during HCCT-2010

    NASA Astrophysics Data System (ADS)

    Roth, A.; Schneider, J.; Klimach, T.; Mertes, S.; van Pinxteren, D.; Herrmann, H.; Borrmann, S.

    2016-01-01

    Cloud residues and out-of-cloud aerosol particles with diameters between 150 and 900 nm were analysed by online single particle aerosol mass spectrometry during the 6-week study Hill Cap Cloud Thuringia (HCCT)-2010 in September-October 2010. The measurement location was the mountain Schmücke (937 m a.s.l.) in central Germany. More than 160 000 bipolar mass spectra from out-of-cloud aerosol particles and more than 13 000 bipolar mass spectra from cloud residual particles were obtained and were classified using a fuzzy c-means clustering algorithm. Analysis of the uncertainty of the sorting algorithm was conducted on a subset of the data by comparing the clustering output with particle-by-particle inspection and classification by the operator. This analysis yielded a false classification probability between 13 and 48 %. Additionally, particle types were identified by specific marker ions. The results from the ambient aerosol analysis show that 63 % of the analysed particles belong to clusters having a diurnal variation, suggesting that local or regional sources dominate the aerosol, especially for particles containing soot and biomass burning particles. In the cloud residues, the relative percentage of large soot-containing particles and particles containing amines was found to be increased compared to the out-of-cloud aerosol, while, in general, organic particles were less abundant in the cloud residues. In the case of amines, this can be explained by the high solubility of the amines, while the large soot-containing particles were found to be internally mixed with inorganics, which explains their activation as cloud condensation nuclei. Furthermore, the results show that during cloud processing, both sulfate and nitrate are added to the residual particles, thereby changing the mixing state and increasing the fraction of particles with nitrate and/or sulfate. This is expected to lead to higher hygroscopicity after cloud evaporation, and therefore to an increase of

  6. Land of the free, home of the (un)regulated: A look at market-building and liberalization in the EU and the US

    NASA Astrophysics Data System (ADS)

    Hoffmann, Leif Soren Birger Per Ove Holm

    In my dissertation I argue that because the European Union and the United States of America have been largely treated as unique or at least special cases, both the literature on American-state building and that on European market integration have missed how close comparison alters both our descriptive views and social-scientific explanations of the shape of each polity. In particular, scholars have not sufficiently recognized that the European Union has gone further than the United States in many elements of the creation of a centralized, liberalized single market, nor have they produced explanations that account well for this development. This study challenges the dominant assumption that the United States is generally more hierarchical and centralized than the European Union and more of a single free market in the sense of fewer allowable trade barriers. By analyzing the rules of market integration in services (over 70% of GDP), public procurement (15 -- 20% GDP) and the regulated goods markets (goods like elevators with their own regulatory regimes), I demonstrate that in all these major cases the European Union has adopted rules that open exchange to competition more than the United States. While the actual integration of flows on the ground is still generally less across European states than American ones, the political rules are more - and more liberally - integrated in Europe. I offer an institutional and ideational argument to explain these differences, with two main parts. First, there is no American parallel to the institution of the European Commission, which is mandated to continually push liberalization forward. My research shows that Commission leadership has been critical to each of the examined cases. Second, broader norms of legitimate governance favor centralized authority - including liberalizing central authority - more in the European Union than in the United States. Despite all the criticism we hear of the European Union, the basic notion of

  7. Myths and Realities of Academic Labor Markets.

    ERIC Educational Resources Information Center

    Fairweather, James S.

    1995-01-01

    Examines national data on 4,481 full-time college and university faculty to develop a pay model derived from competing propositions (market segmentation, single national market, and incentive-based perspectives) concerning salary's role in faculty rewards. Findings suggest a blend of market segmentation with a national market perspective rewarding…

  8. Student Marketing for Colleges and Universities

    ERIC Educational Resources Information Center

    Whiteside, Richard

    2004-01-01

    AACRAO's new publication "Student Marketing for Colleges and Universities" is the single authoritative source interpreting basic and advanced marketing techniques within the context of student marketing. Four sections address marketing fundamentals in the higher education setting, strategic planning, consumer behavior of the college-bound student…

  9. Cointegration analysis and influence rank—A network approach to global stock markets

    NASA Astrophysics Data System (ADS)

    Yang, Chunxia; Chen, Yanhua; Niu, Lei; Li, Qian

    2014-04-01

    In this paper, cointegration relationships among 26 global stock market indices over the periods of sub-prime and European debt crisis and their influence rank are investigated by constructing and analyzing directed and weighted cointegration networks. The obtained results are shown as follows: the crises have changed cointegration relationships among stock market indices, their cointegration relationship increased after the Lehman Brothers collapse, while the degree of cointegration gradually decreased from the sub-prime to European debt crisis. The influence of US, Japan and China market indices are entirely distinguished over different periods. Before European debt crisis US stock market is a ‘global factor’ which leads the developed and emerging markets, while the influence of US stock market decreased evidently during the European debt crisis. Before sub-prime crisis, there is no significant evidence to show that other stock markets co-move with China stock market, while it becomes more integrated with other markets during the sub-prime and European debt crisis. Among developed and emerging stock markets, the developed stock markets lead the world stock markets before European debt crisis, while due to the shock of sub-prime and European debt crisis, their influences decreased and emerging stock markets replaced them to lead global stock markets.

  10. AGORA--IV. The Low-Skilled on the European Labour Market: Prospects and Policy Options. Towards a Minimum Learning Platform (Thessaloniki, Greece, October 29-30, 1998). CEDEFOP Panorama.

    ERIC Educational Resources Information Center

    European Centre for the Development of Vocational Training, Thessaloniki (Greece).

    This booklet describes the proceedings of the fourth AGORA conference in Greece conducted by a European team of the Newskills project. (The Newskills project examines the employment prospects of those with a low level of formal education in Europe, and aims to raise awareness of the importance of a minimum learning platform after consultation with…

  11. Marketing fundamentals.

    PubMed

    Redmond, W H

    2001-01-01

    This chapter outlines current marketing practice from a managerial perspective. The role of marketing within an organization is discussed in relation to efficiency and adaptation to changing environments. Fundamental terms and concepts are presented in an applied context. The implementation of marketing plans is organized around the four P's of marketing: product (or service), promotion (including advertising), place of delivery, and pricing. These are the tools with which marketers seek to better serve their clients and form the basis for competing with other organizations. Basic concepts of strategic relationship management are outlined. Lastly, alternate viewpoints on the role of advertising in healthcare markets are examined.

  12. Standardizing the European Education Policy Space

    ERIC Educational Resources Information Center

    Lawn, Martin

    2011-01-01

    Countries in Europe, through the European Union, are creating, as part of the market and its governance, a new policy space in education. It is being formed through law, regulation, networking and harmonization. The development of standards across the different fields of policy, statistical calculation and commerce underpins and extends the…

  13. Regulatory pathways in the European Union.

    PubMed

    Kohler, Manuela

    2011-01-01

    In principle, there are three defined procedures to obtain approval for a medicinal product in the European Union. As discussed in this overview of the procedures, the decision on which regulatory pathway to use will depend on the nature of the active substance, the target indication(s), the history of product and/or the marketing strategy.

  14. Gain loss asymmetry for emerging stock markets

    NASA Astrophysics Data System (ADS)

    Karpio, Krzysztof; Załuska–Kotur, Magdalena A.; Orłowski, Arkadiusz

    2007-03-01

    Stock indexes for some European emerging markets are analyzed using an investment-horizon approach. Austrian ATX index and Dow Jones have been studied and compared with several emerging European markets. The optimal investment horizons are plotted as a function of an absolute return value. Gain-loss asymmetry, originally found for American DJIA index, is observed for all analyzed data. It is shown, that this asymmetry has different character for emerging and for established markets. For established markets, gain curve lies typically above loss curve, whereas in the case of emerging markets the situation is just the opposite. We propose a measure quantifying the gain-loss asymmetry that clearly exhibits a difference between emerging and established markets.

  15. International Voluntary Renewable Energy Markets (Presentation)

    SciTech Connect

    Heeter, J.

    2012-06-01

    This presentation provides an overview of international voluntary renewable energy markets, with a focus on the United States and Europe. The voluntary renewable energy market is the market in which consumers and institutions purchase renewable energy to match their electricity needs on a voluntary basis. In 2010, the U.S. voluntary market was estimated at 35 terawatt-hours (TWh) compared to 300 TWh in the European market, though key differences exist. On a customer basis, Australia has historically had the largest number of customers, pricing for voluntary certificates remains low, at less than $1 megawatt-hour, though prices depend on technology.

  16. Can Low-Income Single Parents Move up in the Labor Market? Findings from the Employment Retention and Advancement Project. Practitioner Brief

    ERIC Educational Resources Information Center

    Miller, Cynthia; Deitch, Victoria; Hill, Aaron

    2011-01-01

    The Employment Retention and Advancement (ERA) project evaluated strategies to promote employment stability among low-income workers. This practitioner brief examines the work, education, and training patterns of single parents in the ERA project. Three years after entering the study, only one in four single parents had advanced. Most of the…

  17. Marketing 101.

    ERIC Educational Resources Information Center

    Henderson, Karla A.

    1997-01-01

    A marketing model for camps includes a mix of services, presentation, and communication elements that promote the virtues of camp, convince potential campers and their families of the benefits of camp, and successfully distinguish the camp from others. Includes resources related to marketing strategies, theme merchandise, and market trends…

  18. Marketing new medical devices.

    PubMed

    LoBuglio, R J

    1988-01-01

    The marketing concept says that a firm should focus all of its efforts on satisfying its customers, at a profit. This is really a a new philosophy of business, replacing a production-oriented philosophy which focused on organizing a firm's resources to make products and then selling them. The marketing concept calls for reorienting the firm's ways of doing things. Instead of trying to get customers to buy what the firm has produced, a marketing-oriented firm would try to sell what the customers want. The underlying principle of the marketing concept is that a firm should seek to meet the needs of customers, at a profit, rather than place its main emphasis on its own internal activities and utilization of its resources. These latter factors are also important, of course, but those who believe in the marketing concept feel that customers' needs should be the firm's primary focus and that resources should be organized to satisfy those needs. Give the customer what he needs--this may seem so obvious and logical that it is difficult to understand why the marketing concept is considered such a breakthrough. However, people haven't always done the logical and obvious. In a typical company, production men thought mainly about getting the product out. Accountants were only interested in balancing the books. Financial people were absorbed in the company's cash position. And salesmen were mainly concerned with getting orders. No one was particularly concerned with whether the whole system made sense. As long as the company made a profit, each department went merrily on its independent way, "doing its own thing." Unfortunately, they still do in the majority of companies today. Finding out customer's attitudes can avoid prejudices and stereotypes commonly found in the typical organization. The need for market research to avoid stereotypes can be dramatized by the following results from a large-scale survey of European adults: The average Frenchman uses almost twice as many

  19. The future of health care in six European countries: the views of policy elites.

    PubMed

    Taylor-Gooby, P

    1996-01-01

    A recent study was made of the views of politicians, representatives of trade unions, business organizations, and others likely to be influential in policy making, on the future of health care provision in six European Union (E.U.) countries. This article discusses the findings. While common problems of rising cost resulting from population aging are recognized in all countries, the way these issues are interpreted and the policies seen as appropriate to tackle them differ. Views are strongly influenced by the organizational structure of the existing provision. This supports the "new institutionalist" view that policy feedback plays an important role in shaping policy reform. It also indicates that the potential for convergence in E.U. social policy is more limited than suggestions that the single European market will lead to an "ever closer union" might imply.

  20. Capacity Markets and Market Stability

    SciTech Connect

    Stauffer, Hoff

    2006-04-15

    The good news is that market stability can be achieved through a combination of longer-term contracts, auctions for far enough in the future to permit new entry, a capacity management system, and a demand curve. The bad news is that if and when stable capacity markets are designed, the markets may seem to be relatively close to where we started - with integrated resource planning. Market ideologues will find this anathema. (author)

  1. EDEX Educational Expansion and Labour Market: A Comparative Study of Five European Countries--France, Germany, Italy, Spain and the United Kingdom with Special Reference to the United States. CEDEFOP Reference Series.

    ERIC Educational Resources Information Center

    Beduwe, Catherine; Planas, Jordi

    The long-term economic and social impacts of the rise in levels of education on mechanisms of access to employment and on human resources management were examined in a comparative study of educational expansion and the labor markets of France, Germany, Italy, Spain, and the United Kingdom, with special reference to the United States. Five teams of…

  2. Market impact and structure dynamics of the Chinese stock market based on partial correlation analysis

    NASA Astrophysics Data System (ADS)

    Li, Xing; Qiu, Tian; Chen, Guang; Zhong, Li-Xin; Wu, Xiao-Run

    2017-04-01

    Partial correlation analysis is employed to study the market impact on the Chinese stock market from both the native and external markets. Whereas the native market index is observed to have a great impact on the market correlations for both the Shanghai and Shenzhen stock markets, some external stock indices of the United States, European and Asian stock markets show a slight influence on the Chinese market. The individual stock can be affected by different economic sectors, but the dominant influence is from the sector the stock itself belongs to or closely related to, and the finance and insurance sector shows a weaker correlation with other economic sectors. Moreover, the market structure similarity exhibits a negative correlation with the price return in most time, and the structure similarity decays with the time interval.

  3. Joint Venture Marketing Training: Development Marketing Plans Utilizing Foreign and American Students.

    ERIC Educational Resources Information Center

    Steele, David; Jones, Kevin

    This paper describes a workshop prepared and presented by the Business Administration Department of the University of Wisconsin-Eau Claire, that is designed to provide training in evaluating a European market for an American product and preparing a plan for marketing the product in Europe. It is noted that the program can work with both students…

  4. The Integration of Immigrants Into the Labour Markets of the EU. IAB Labour Market Research Topics.

    ERIC Educational Resources Information Center

    Werner, Heinz

    Integration of foreign workers into European Union (EU) labor markets was evaluated. Three indicators of labor market integration were analyzed: unemployment rate, employment rate, and self- employment rate. Results were drawn from the Labor Force Survey data compiled by Eurostat. Findings indicated that, in all EU countries, the unemployment rate…

  5. Microbial community structure and dynamics in two-stage vs single-stage thermophilic anaerobic digestion of mixed swine slurry and market bio-waste.

    PubMed

    Merlino, Giuseppe; Rizzi, Aurora; Schievano, Andrea; Tenca, Alberto; Scaglia, Barbara; Oberti, Roberto; Adani, Fabrizio; Daffonchio, Daniele

    2013-04-15

    The microbial community of a thermophilic two-stage process was monitored during two-months operation and compared to a conventional single-stage process. Qualitative and quantitative microbial dynamics were analysed by Denaturing Gradient Gel Electrophoresis (DGGE) and real-time PCR techniques, respectively. The bacterial community was dominated by heat-shock resistant, spore-forming clostridia in the two-stage process, whereas a more diverse and dynamic community (Firmicutes, Bacteroidetes, Synergistes) was observed in the single-stage process. A significant evolution of bacterial community occurred over time in the acidogenic phase of the two-phase process with the selection of few dominant species associated to stable hydrogen production. The archaeal community, dominated by the acetoclastic Methanosarcinales in both methanogen reactors, showed a significant diversity change in the single-stage process after a period of adaptation to the feeding conditions, compared to a constant stability in the methanogenic reactor of the two-stage process. The more diverse and dynamic bacterial and archaeal community of single-stage process compared to the two-stage process accounted for the best degradation activity, and consequently the best performance, in this reactor. The microbiological perspective proved a useful tool for a better understanding and comparison of anaerobic digestion processes.

  6. Marketing Education

    ERIC Educational Resources Information Center

    Stancil, Ronald A., Sr.

    2008-01-01

    This article discusses the Marketing Education program at West Haven (CT) High School in West Haven, Connecticut, that promotes skills for life and attributes, enhances the academic program, and develops leaders out of ordinary students through an interactive curriculum. The three components of West Haven's marketing and management program are (1)…

  7. Marketing Training

    NASA Technical Reports Server (NTRS)

    Leonard, Eric

    1998-01-01

    All of our ideas have been field tested and have proven effective in our environment. Our objectives are: We will share our ideas about marketing training and what we've implemented at Michoud Space Systems. You will go away with at least one new idea or insight about how to more effectively market your training.

  8. Agricultural Marketing.

    ERIC Educational Resources Information Center

    Helt, Lawrence; And Others

    Designed for use in farm business management adult programs, this marketing curriculum includes six teaching lessons and professional staff products. The following topics are covered in the lessons: introduction to marketing; interpretation of price/demand/supply cycles and fundamental outlook trends (carryover/projections/disappearance); farmers'…

  9. Tourism Marketing.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Vocational Education.

    This document contains teacher materials for a 6-unit, 1-year distributive education course in marketing tourism offered in grades 11 and 12 in North Carolina. Although in general the material presented concerns marketing tourism anywhere, some of it is specifically related to tourism within North Carolina. A purpose statement explains the…

  10. Overview of European technology in computers, telecommunications, and electronics

    NASA Astrophysics Data System (ADS)

    Blackburn, J. F.

    1990-05-01

    The emergence of the personal computer, the growing use of distributed systems, and the increasing demand for supercomputers and mini-supercomputers are causing a profound impact on the European computer market. An equally profound development in telecommunications is the integration of voice, data, and images in the public network systems - the Integrated Service Digital Network (ISDN). The programs being mounted in Europe to meet the challenges of these technologies are described. The Europe-wide trends and actions with respect to computers, telecommunications, and microelectronics are discussed, and the major European collaborative programs in these fields are described. Specific attention is given to the European Strategic Programme for Research and Development in Information (ESPRIT); Research in Advanced Communications for Europe (RACE); European Research Coordination Agency (Eureka) programs; Joint European Submicron Silicon Initiative (JESSI); and the recently combined programs Basic Research Industrial Technologies in Europe/European Research in Advanced Materials (BRITE/EURAM).

  11. Empirical evaluation of the market price of risk using the CIR model

    NASA Astrophysics Data System (ADS)

    Bernaschi, M.; Torosantucci, L.; Uboldi, A.

    2007-03-01

    We describe a simple but effective method for the estimation of the market price of risk. The basic idea is to compare the results obtained by following two different approaches in the application of the Cox-Ingersoll-Ross (CIR) model. In the first case, we apply the non-linear least squares method to cross sectional data (i.e., all rates of a single day). In the second case, we consider the short rate obtained by means of the first procedure as a proxy of the real market short rate. Starting from this new proxy, we evaluate the parameters of the CIR model by means of martingale estimation techniques. The estimate of the market price of risk is provided by comparing results obtained with these two techniques, since this approach makes possible to isolate the market price of risk and evaluate, under the Local Expectations Hypothesis, the risk premium given by the market for different maturities. As a test case, we apply the method to data of the European Fixed Income Market.

  12. Comovements in government bond markets: A minimum spanning tree analysis

    NASA Astrophysics Data System (ADS)

    Gilmore, Claire G.; Lucey, Brian M.; Boscia, Marian W.

    2010-11-01

    The concept of a minimum spanning tree (MST) is used to study patterns of comovements for a set of twenty government bond market indices for developed North American, European, and Asian countries. We show how the MST and its related hierarchical tree evolve over time and describe the dynamic development of market linkages. Over the sample period, 1993-2008, linkages between markets have decreased somewhat. However, a subset of European Union (EU) bond markets does show increasing levels of comovements. The evolution of distinct groups within the Eurozone is also examined. The implications of our findings for portfolio diversification benefits are outlined.

  13. Bayou Vista: A Market-Driven Development

    ERIC Educational Resources Information Center

    Izzo, G. Martin; Teal, Elisabeth J.

    2012-01-01

    The case touches on several areas of marketing: ethics, sales issues, conflicts of interest, marketing forecasts, and issues of pricing. Joe Brice, the visionary and real estate broker for a 36-lot subdivision of moderately priced single-family homes targeting the $190,000 to $260,000 range, seems to have identified an unmet housing market,…

  14. Market trends

    NASA Technical Reports Server (NTRS)

    Fitzsimmons, R. D.

    1976-01-01

    A very large segment of the over water, long haul passenger market, 31% of the passengers who provide 42% of the passenger revenue, offers a significant market for an advanced supersonic transport. This is for both the first class and full-fare economy passenger markets. The supersonic transport may be more competitive here in spite of lower costs of subsonic transports, as passenger preference is a more powerful variable than DOC. This latter fact was amply demonstrated in the late fifties when the jets completely replaced the reciprocating engine transports on most world routes, in spite of slightly higher fares.

  15. Marketing Reflections.

    ERIC Educational Resources Information Center

    Bush, Gale; Kwielford, Merrilee Andersen

    2001-01-01

    Discusses marketing techniques for teacher librarians based on six levels: basic assumptions; library resource program, including attitudes for success; school, including a collaborative environment; administration, including program support; community, including awareness; and state and national, including professional participation. (LRW)

  16. Greenhouse-gas-trading markets.

    PubMed

    Sandor, Richard; Walsh, Michael; Marques, Rafael

    2002-08-15

    This paper summarizes the extension of new market mechanisms for environmental services, explains of the importance of generating price information indicative of the cost of mitigating greenhouse gases (GHGs) and presents the rationale and objectives for pilot GHG-trading markets. It also describes the steps being taken to define and launch pilot carbon markets in North America and Europe and reviews the key issues related to incorporating carbon sequestration into an emissions-trading market. There is an emerging consensus to employ market mechanisms to help address the threat of human-induced climate changes. Carbon-trading markets are now in development around the world. A UK market is set to launch in 2002, and the European Commission has called for a 2005 launch of an European Union (EU)-wide market, and a voluntary carbon market is now in formation in North America. These markets represent an initial step in resolving a fundamental problem in defining and implementing appropriate policy actions to address climate change. Policymakers currently suffer from two major information gaps: the economic value of potential damages arising from climate changes are highly uncertain, and there is a lack of reliable information on the cost of mitigating GHGs. These twin gaps significantly reduce the quality of the climate policy debate. The Chicago Climate Exchange, for which the authors serve as lead designers, is intended to provide an organized carbon-trading market involving energy, industry and carbon sequestration in forests and farms. Trading among these diverse sectors will provide price discovery that will help clarify the cost of combating climate change when a wide range of mitigation options is employed. By closing the information gap on mitigation costs, society and policymakers will be far better prepared to identify and implement optimal policies for managing the risks associated with climate change. Establishment of practical experience in providing

  17. Labor Markets and Economic Incorporation among Recent Immigrants in Europe

    ERIC Educational Resources Information Center

    Kogan, Irena

    2006-01-01

    The questions asked in the paper are whether and to what extent the employment situation among recent third-country immigrants differs across European Union countries and how it is related to these countries' labor market characteristics. The European Labor Force Survey data for the 1990s are used to disentangle the roles that the individual…

  18. Case Studies as Practical Teaching in the New Marketing Courses

    ERIC Educational Resources Information Center

    Mondéjar-Jiménez, Juan-Antonio; Cordente-Rodríguez, María; Gómez-Borja, Miguel-Ángel; Andrés-Martínez, María-Encarnación; Gázquez-Abad, Juan-Carlos

    2010-01-01

    The European Higher Education Area is assuming a change in the teaching-learning of all European universities. The area of Marketing, traditionally characterized by being at the forefront in terms of educational innovation, faces the challenge of finding new tools to facilitate the work of students by encouraging their involvement in the…

  19. [Biobanks European infrastructure].

    PubMed

    Kinkorová, Judita; Topolčan, Ondřej

    2016-01-01

    Biobanks are structured repositories of human tissue samples connected with specific information. They became an integral part of personalized medicine in the new millennium. At the European research area biobanks are isolated not well coordinated and connected to the network. European commission supports European infrastructure BBMRI-ERIC (Biobanks and Biomolecular Resources Research Infrastructure European Research Infrastructure Consortium), consortium of 54 members with more than 225 associated organizations, largely biobanks from over 30 countries. The aim is to support biomedical research using stored samples. Czech Republic is a member of the consortium as a national node BBMRI_CZ, consisting of five partners.

  20. Status of European appliance standards

    SciTech Connect

    Turiel, I.; Lebot, B.

    1992-05-01

    The European Community (EC) recently commissioned a study of the impact of potential appliance standards on electricity consumption in the twelve EC nations. This study looks at refrigerators, freezers, dishwashers, clothes washers, and clothes dryers. The impact of minimum efficiency standards on electricity use over the time period from 1995--2010 is estimated. The results of this study were presented to the EC in September of 1991. Revisions were made to the draft report and final copies sent to all interested parties. The member nations of the EC will soon consider whether they wish to implement uniform energy efficiency standards that would take effect in 1995. The results of the study described above will be presented and the political considerations will be discussed. In addition, data describing the appliance market in Europe will be presented.

  1. European Generic Medicines Association (EGA)--16th Annual Conference.

    PubMed

    Kennedy, Bob

    2010-08-01

    The 16th Annual Conference of the European Generic Medicines Association (EGA), held in Rome, included topics covering new developments and challenges in the generic medicines industry in Europe. This conference report highlights selected presentations on developments for generics in the Italian healthcare system, a summary of the EGA pharmaceutical sector inquiry on the delayed market entry of generics, developments and trends in the European generics market, the evolution and growth of the global generics industry, and a CEO perspective on the challenges facing the industry.

  2. Superconducting cavity material for the European XFEL

    NASA Astrophysics Data System (ADS)

    Singer, W.; Singer, X.; Brinkmann, A.; Iversen, J.; Matheisen, A.; Navitski, A.; Tamashevich, Y.; Michelato, P.; Monaco, L.

    2015-08-01

    Analysis of the strategy for superconducting cavity material procurement and quality management is done on the basis of the experience with the cavity production for the European x-ray free electron laser (EXFEL) facility. An adjustment of the material specification to EXFEL requirements, procurement of material, quality control (QC), documentation, and shipment to cavity producers have been worked out and carried out by DESY. A multistep process of qualification of the material suppliers included detailed material testing, single- and nine-cell cavity fabrication, and cryogenic radiofrequency tests. Production of about 25 000 semi-finished parts of high purity niobium and niobium-titanium alloy in a period of three years has been divided finally between companies Heraeus, Tokyo Denkai, Ningxia OTIC, and PLANSEE. Consideration of large-grain (LG) material as a possible option for the EXFEL has resulted in the production of one cryogenic module consisting of seven (out of eight) LG cavities. LG materials fulfilled the EXFEL requirements and showed even 25% to 30% higher unloaded quality factor. A possible shortage of the required quantity of LG material on the market led, however, to the choice of conventional fine-grain (FG) material. Eddy-current scanning (ECS) has been applied as an additional QC tool for the niobium sheets and contributed significantly to the material qualification and sorting. Two percent of the sheets have been rejected, which potentially could affect up to one-third of the cavities. The main imperfections and defects in the rejected sheets have been analyzed. Samples containing foreign material inclusions have been extracted from the sheets and electrochemically polished. Some inclusions remained even after 150 μm surface layer removal. Indications of foreign material inclusions have been found in the industrially fabricated and treated cavities and a deeper analysis of the defects has been performed.

  3. European veterinary education: a bridge to quality.

    PubMed

    Fernandes, Tito H

    2005-03-01

    The aim of this review is to provide an insight into the current state of, and future changes in, veterinary education within the European Community, as well as the role of the European Association of Establishments for Veterinary Education (EAEVE) in evaluating and raising standards of education and training. It also describes the role of EAEVE in developing strategies for changes in the future. Veterinary schools have traditionally aimed at producing the omnicompetent veterinarian at graduation. Many have questioned whether this is possible, and a recent European Commission (EC) funded market survey has confirmed that this is indeed an impossible task and has identified the requirements of society within the European Union (EU) for veterinary services in the future. There is however a need to change the current 1978 European Directive. The current mechanisms which have been used by EAEVE to evaluate over 100 veterinary schools in Europe and their relationship with other systems of appraisal are described. The future of veterinary education within the context of higher education in Europe as part of the Bologna process and in relation to standards of veterinary education worldwide are discussed. Whilst the merits of standardisation of educational quality so that there can be mutual recognition of qualifications are supported, the need to preserve the strengths associated with the diversity of approaches and teaching methods is strongly advocated.

  4. European auxiliary propulsion, 1972

    NASA Technical Reports Server (NTRS)

    Holcomb, L. B.

    1972-01-01

    The chemical and electric auxiliary propulsion technology of the United Kingdom, France, and West Germany is discussed in detail, and the propulsion technology achievements of Italy, India, Japan, and Russia are reviewed. A comparison is presented of Shell 405 catalyst and a European spontaneous hydrazine catalyst called CNESRO I. Finally, conclusions are drawn regarding future trends in European auxiliary propulsion technology development.

  5. A Medical Language Processor for Two Indo-European Languages

    PubMed Central

    Nhan, Ngo Thanh; Sager, Naomi; Lyman, Margaret; Tick, Leo J.; Borst, François; Su, Yun

    1989-01-01

    The syntax and semantics of clinical narrative across Indo-European languages are quite similar, making it possible to envison a single medical language processor that can be adapted for different European languages. The Linguistic String Project of New York University is continuing the development of its Medical Language Processor in this direction. The paper describes how the processor operates on English and French.

  6. Marketing percolation

    NASA Astrophysics Data System (ADS)

    Goldenberg, J.; Libai, B.; Solomon, S.; Jan, N.; Stauffer, D.

    2000-09-01

    A percolation model is presented, with computer simulations for illustrations, to show how the sales of a new product may penetrate the consumer market. We review the traditional approach in the marketing literature, which is based on differential or difference equations similar to the logistic equation (Bass, Manage. Sci. 15 (1969) 215). This mean-field approach is contrasted with the discrete percolation on a lattice, with simulations of "social percolation" (Solomon et al., Physica A 277 (2000) 239) in two to five dimensions giving power laws instead of exponential growth, and strong fluctuations right at the percolation threshold.

  7. From heterogeneity to harmonization? Recent trends in European health policy.

    PubMed

    Gerlinger, Thomas; Urban, Hans-Jürgen

    2007-01-01

    In the European Union (EU), health policy and the institutional reform of health systems have been treated primarily as national affairs, and health care systems within the EU thus differ considerably. However, the health policy field is undergoing a dynamic process of Europeanization. This process is stimulated by the orientation towards a more competitive economy, recently inaugurated and known as the Lisbon Strategy, while the regulatory requirements of the European Economic and Monetary Union are stimulating the Europeanization of health policy. In addition, the so-called open method of coordination, representing a new mode of regulation within the European multi-level system, is applied increasingly to the health policy area. Diverse trends are thus emerging. While the Lisbon Strategy goes along with a strategic upgrading of health policy more generally, health policy is increasingly used to strengthen economic competitiveness. Pressure on Member States is expected to increase to contain costs and promote market-based health care provision.

  8. Carbon markets proliferating despite difficulties, report notes

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-06-01

    Although some existing carbon markets are facing structural issues and economic difficulties in Europe have put a damper on the European Union emissions trading system, new carbon pricing initiatives are developing rapidly, and these initiatives could help slow down greenhouse gas emissions, according to a 29 May report from the World Bank.

  9. The Market Prospects for Consumer Online Services in Europe.

    ERIC Educational Resources Information Center

    White, Martin

    The rapid growth over the last few years of online services designed to appeal to a mass market audience in the United States encouraged many of the companies operating these services to consider launching them in Europe. This paper concentrates primarily on the European market of online services. The services fall into three categories: United…

  10. Sports Marketing.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Career-Technical and Adult Education.

    This document presents the Ohio Integrated Technical and Academic Competency profile for sports marketing. The profile is to serve as the basis for curriculum development in Ohio's secondary, adult, and postsecondary programs. The profile includes a comprehensive listing of 999 specialty key indicators for evaluating mastery of 113 competencies in…

  11. Marketing Reference Services.

    ERIC Educational Resources Information Center

    Norman, O. Gene

    1995-01-01

    Relates the marketing concept to library reference services. Highlights include a review of the literature and an overview of marketing, including research, the marketing mix, strategic plan, marketing plan, and marketing audit. Marketing principles are applied to reference services through the marketing mix elements of product, price, place, and…

  12. European comparisons between mental health services.

    PubMed

    Wahlbeck, K

    2011-03-01

    When developing accessible, affordable and effective mental health systems, exchange of data between countries is an important moving force towards better mental health care. Unfortunately, health information systems in most countries are weak in the field of mental health, and comparability of data is low. Special international data collection exercises, such as the World Health Organization (WHO) Atlas Project and the WHO Baseline Project have provided valuable insights in the state of mental health systems in countries, but such single-standing data collections are not sustainable solutions. Improvements in routine data collection are urgently needed. The European Commission has initiated major improvements to ensure harmonized and comprehensive health data collection, by introducing the European Community Health Indicators set and the European Health Interview Survey. However, both of these initiatives lack strength in the field of mental health. The neglect of the need for relevant and valid comparable data on mental health systems is in conflict with the importance of mental health for European countries and the objectives of the 'Europe 2020' strategy. The need for valid and comparable mental health services data is today addressed only by single initiatives, such as the Organisation for Economic Co-operation and Development work to establish quality indicators for mental health care. Real leadership in developing harmonized mental health data across Europe is lacking. A European Mental Health Observatory is urgently needed to lead development and implementation of monitoring of mental health and mental health service provision in Europe.

  13. Storage battery market: profiles and trade opportunities

    NASA Astrophysics Data System (ADS)

    Stonfer, D.

    1985-04-01

    The export market for domestically produced storage batteries is a modest one, typically averaging 6 to 7% of domestic industry shipments. Exports in 1984 totalled about $167 million. Canada and Mexico were the largest export markets for US storage batteries in 1984, accounting for slightly more than half of the total. The United Kingdom, Saudi Arabia, and the Netherlands round out the top five export markets. Combined, these five markets accounted for two-thirds of all US exports of storage batteries in 1984. On a regional basis, the North American (Canada), Central American, and European markets accounted for three-quarters of total storage battery exports. Lead-acid batteries accounted for 42% of total battery exports. Battery parts followed lead-acid batteries with a 29% share. Nicad batteries accounted for 16% of the total while other batteries accounted for 13%.

  14. Wind energy: A review of technical and market issues

    SciTech Connect

    Garrad, A.D.

    1996-12-31

    Opinions on the world market for wind power are presented in this paper. The paper is divided into three sections: the market, the technology, and general conclusions. The market section compares European and US wind energy growth and contributing factors and barriers to growth. A technology overview discusses wind turbine concepts, mass reduction, blade structural flexibility, and growth in machine size. Political decisions, economic aspects, public acceptance, and technology limitations are assessed for their influence on the growth of wind energy. 11 figs.

  15. The European experience.

    PubMed

    Roels, Leo; Rahmel, Axel

    2011-04-01

    This mini-review on European experiences with tackling the problem of organ shortage for transplantation was based on a literature review of predominantly European publications dealing with the issue of organ donation from deceased donors. The authors tried to identify the most significant factors that have demonstrated to impact on donation rates from deceased donors and subsequent transplant successes. These factors include legislative measures (national laws and European Directives), optimization of the donation process, use of expanded criteria donors, innovative preservation and surgical techniques, organizational efforts, and improved allocation algorithms.

  16. The European Spallation Source

    SciTech Connect

    Lindroos M.; Calaga R.; Bousson S.; Danared H.; Devanz G. et al

    2011-04-20

    In 2003 the joint European effort to design a European Spallation Source (ESS) resulted in a set of reports, and in May 2009 Lund was agreed to be the ESS site. The ESS Scandinavia office has since then worked on setting all the necessary legal and organizational matters in place so that the Design Update and construction can be started in January 2011, in collaboration with European partners. The Design Update phase is expected to end in 2012, to be followed by a construction phase, with first neutrons expected in 2018-2019.

  17. European journals on microbiology.

    PubMed

    Ronda, C; Vázquez, M

    1997-12-01

    A survey on the scientific journals dealing with microbiology published in Europe has been carried out. Eighteen European countries publish microbiological journals with the United Kingdom. Netherlands and Germany leading in number of journals on this specialty. Most of the European journals on microbiology are published bimonthly (27%), and English is the most common language used (54%). Most of these journals (86%) are included in some database, but only 36 (25%) are indexed in the six databases studied. Out of the 146 journals registered, 71 (49%), published in 11 European countries, are included in the 1995 Journal Citation Reports (ISI, Philadelphia).

  18. Functional Significance of Single Nucleotide Polymorphisms in the Lactase Gene in Diverse United States Subjects and Evidence for a Novel Lactase Persistence Allele at -13909 in Those of European Ancestry

    PubMed Central

    Baffour-Awuah, Nana Yaa; Fleet, Sarah; Baker, Susan S.; Butler, Johannah L.; Campbell, Catarina; Tischfield, Samuel; Mitchell, Paul D.; Moon, Jennifer E.; Allende-Richter, Sophie; Fishman, Laurie; Bousvaros, Athos; Fox, Victor; Kuokkanen, Mikko; Montgomery, Robert K.; Grand, Richard J.; Hirschhorn, Joel N.

    2014-01-01

    Objectives Recent data from mainly homogeneous European and African populations implicate a 140 bp region 5′ to the transcriptional start site of LCT (the lactase gene) as a regulatory site for lactase persistence and non-persistence. As there are no studies of United States non-homogeneous populations, we performed genotype/phenotype analysis of the -13910 and -22018 LCT SNPs in New England children, mostly of European ancestry. Methods Duodenal biopsies were processed for disaccharidase activities, RNA quantification by RT-PCR, allelic expression ratios by PCR, and genotyping and SNP analysis. Results were compared to clinical information. Results Lactase activity and mRNA levels, as well as sucrase-to-lactase ratios of enzyme activity and mRNA, showed robust correlations with genotype. None of the other LCT SNPs showed as strong a correlation with enzyme or mRNA activities as did -13910. Data were consistent with the -13910 being the causal sequence variant rather than -22018. Four individuals heterozygous for -13910T/C had allelic expression patterns similar to individuals with -13910C/C genotypes; of these, 2 showed equal LCT expression from the 2 alleles and a novel variant (-13909C>A) associated with lactase persistence. Conclusion The identification of -13910C/C genotype is very likely to predict lactase non-persistence, consistent with prior published studies. A -13910T/T genotype will frequently, but not perfectly, predict lactase persistence in this mixed European-ancestry population; a -13910T/C genotype will not predict the phenotype. A long, rare haplotype in 2 individuals with -13910T/C genotype but equal allele-specific expression contains a novel lactase persistence allele present at -13909. PMID:25625576

  19. European opportunities for fuel cell commercialisation

    NASA Astrophysics Data System (ADS)

    Gibbs, C. E.; Steel, M. C. F.

    1992-01-01

    The European electricity market is changing. This paper will look at the background to power generation in Europe and highlight the recent factors which have entered the market to promote change. The 1990s seem to offer great possibilities for fuel cell commercialisation. Awareness of environmental problems has never been greater and there is growing belief that fuel cell technology can contribute to solving some of these problems. Issues which have caused the power industry in Europe to re-think its methods of generation include: concern over increasing carbon dioxide emissions and their contribution to the greenhouse effect; increasing SO x and NO x emissions and the damage cause by acid rain; the possibility of adverse effects on health caused by high voltage transmission lines; environmental restrictions to the expansion of hydroelectric schemes; public disenchantment with nuclear power following the Chernobyl accident; avoidance of dependence on imported oil following the Gulf crisis and a desire for fuel flexibility. All these factors are hastening the search for clean, efficient, modular power generators which can be easily sited close to the electricity consumer and operated using a variety of fuels. It is not only the power industry which is changing. A tightening of the legislation concerning emissions from cars is encouraging European auto companies to develop electric vehicles, some of which may be powered by fuel cells. Political changes, such as the opening up of Eastern Europe will also expand the market for low-emission, efficient power plants as attempts are made to develop and clean up that region. Many Europeans organisations are re-awakening their interest, or strengthening their activities, in the area of fuel cells because of the increasing opportunities offered by the European market. While some companies have chosen to buy, test and demonstrate Japanese or American fuel cell stacks with the aim of gaining operational experience and

  20. Serving European Science: The EIROforum Collaboration

    NASA Astrophysics Data System (ADS)

    Madsen, C.

    2004-06-01

    OVER THE LAST FEW years, the idea of a “European Research Area” (ERA) has gained strong support among science policy makers and, increasingly, among scientists themselves. The goal of the ERA is to establish a single “market” for research on our continent, allowing for better co-ordination of research efforts, synergies between projects, the achievement of “critical mass” (both human and financial) and thus to strengthen the competitiveness of European research. These goals necessitate deep structural changes in the way science is organised, breaking up existing borderlines and barriers between national research systems in Europe.

  1. The European Social Fund: A Very Specific Case Instrument of HRD Policy

    ERIC Educational Resources Information Center

    Tome, Eduardo

    2013-01-01

    Purpose: This paper aims to review the intervention of the European Social Fund (ESF) as an instrument of human resource development (HRD) policies in the European labor market. Design/methodology/approach: The paper uses an economic background, and reviews the official documents produced by the ESF during its history to try to define its economic…

  2. Publishing Strategies of Young, Highly Mobile Academics: The Question of Language in the European Context

    ERIC Educational Resources Information Center

    Anderson, Laurie

    2013-01-01

    This paper examines links between publishing strategies and the academic mobility of multilingual entry-level scholars in the European context against the backdrop of European Union (EU) policies and research on academic labor market characteristics, skilled migration and scholarly publishing. An analysis of language of publication, patterns of…

  3. The Structural Disempowerment of Eastern European Migrant Farm Workers in Norwegian Agriculture

    ERIC Educational Resources Information Center

    Rye, Johan Fredrik; Andrzejewska, Joanna

    2010-01-01

    Since the 2004 EU enlargement established one European common labour market, a large number of Eastern Europeans have taken up seasonal employment as hired farm workers in Norwegian agriculture. Much attention in the public has been given to the potential for "social dumping" of these migrating workers, as they are considered prone to…

  4. Operational Implications of the NATO Strategic Concept 2010 for European Countries in NATO and the EU

    DTIC Science & Technology

    2011-12-01

    the field of defense economy , because of its direct impact on national security. National protectionism of the defense markets, however, works into...Permanent Structured Cooperation in Defense - and tied the already operational European Defense Agency (EDA) in the EU. The Lisbon Treaty’s impact on...26 The Lisbon Treaty has a significant impact on the European Union. Particularly, the treaty increased the possibi I ities of European countries

  5. A future European launcher - Ariane 5/Hermes

    NASA Astrophysics Data System (ADS)

    Cretenet, J. C.; Marx, P.

    1984-12-01

    The development of the Ariane launch vehicle was begun in Europe ten years ago to provide independence in terms of the commercial exploitation of telecommunications satellites. In connection with the spectacular development of the satellite market and, consequently, the launch services market, Ariane has now also a commercial objective, which is related to the penetration of the international launch services market. The current capacity of Ariane is adequate for short and medium-term European launch requirements. However, in the longer term, Ariane's capacity is insufficient and a new launcher is needed. It is attempted to evaluate future launching requirements for the 1995-2000 period, taking into account competing launch resources related to the U.S. Space Shuttle. The results of this evaluation lead to a discussion of the characteristics of the Ariane 5, which is to be the new launcher for the 1990s. Attention is given to improved geostationary orbit service, low orbit injection, and the Hermes European manned system.

  6. Informal Food Production in the Enlarged European Union

    ERIC Educational Resources Information Center

    Alber, Jens; Kohler, Ulrich

    2008-01-01

    How widespread is the production of food in old and new member states of the European Union and what is the social meaning or logic of such activities? We show that growing food is (a) more widespread in former communist countries than in traditional market economies and (b) is predominantly a hobby or recreational activity in affluent countries,…

  7. Key Data on Vocational Training in the European Union.

    ERIC Educational Resources Information Center

    European Centre for the Development of Vocational Training, Thessaloniki (Greece).

    This book provides key quantitative and qualitative data on vocational education and training (VET) in the European Union. Among the topics on which data are provided are the following: demographic trends, educational attainment, and the labor market (aging of the population and labor force, changes in educational attainment over time, impacts of…

  8. European PTTI report

    NASA Technical Reports Server (NTRS)

    Cordara, Franco; Grimaldi, Sabrina; Leschiutta, Sigfrido

    1994-01-01

    Time and frequency metrology in Europe presents some peculiar features in its three main components: research on clocks, comparisons and dissemination methods, and dissemination services. Apart from the usual activities of the national metrological laboratories, an increasing number of cooperation between the European countries are promoted inside some European organizations, such as the ECC, EFTA, EUROMET, and WECC. Cooperation between these organizations is covered. The present, evolving situation will be further influenced by the recent political changes in Eastern Europe.

  9. Heterogeneity of the environmental regulation of industrial wastewater: European wineries.

    PubMed

    Román-Sánchez, Isabel M; Aznar-Sánchez, José A; Belmonte-Ureña, Luis J

    2015-01-01

    The European legislation of the pollution of industrial wastewater shows a high degree of heterogeneity. This fact implies that there is a market failure with relevant consequences. Within the European Union, each Member State performs a specific transposition of the Water Framework Directive 2000/60. The member states introduce different sanitation fees to correct water pollution. In this paper, the case of the European wine industry is analyzed. It studies the sanitation fees of the five major wine producing countries: France, Italy, Spain, Germany and Portugal. Results show significant differences among the wastewater fees and the study reveals how such heterogeneity leads to relevant market distortions. The research concludes that more homogeneous environmental regulation would promote more sustainable wine production processes with more efficient water management and purification systems, as well as the introduction of cutting edge technologies.

  10. Does the market maker stabilize the market?

    NASA Astrophysics Data System (ADS)

    Zhu, Mei; Chiarella, Carl; He, Xue-Zhong; Wang, Duo

    2009-08-01

    The market maker plays an important role in price formation, but his/her behavior and stabilizing impact on the market are relatively unclear, in particular in speculative markets. This paper develops a financial market model that examines the impact on market stability of the market maker, who acts as both a liquidity provider and an active investor in a market consisting of two types of boundedly rational speculative investors-the fundamentalists and trend followers. We show that the market maker does not necessarily stabilize the market when he/she actively manages the inventory to maximize profits, and that rather the market maker’s impact depends on the behavior of the speculators. Numerical simulations show that the model is able to generate outcomes for asset returns and market inventories that are consistent with empirical findings.

  11. Generation of a Catalogue of European Windstorms

    NASA Astrophysics Data System (ADS)

    Varino, Filipa; Baptiste Granier, Jean; Bordoy, Roger; Arbogast, Philippe; Joly, Bruno; Riviere, Gwendal; Fandeur, Marie-Laure; Bovy, Henry; Mitchell-Wallace, Kirsten; Souch, Claire

    2016-04-01

    The probability of multiple wind-storm events within a year is crucial to any (re)insurance company writing European wind business. Indeed, the volatility of losses is enhanced by the clustering of storms (cyclone families), as occurred in early 1990 (Daria, Vivian, Wiebke), December 1999 (Lothar, Martin) or December 2015 (Desmond, Eva, Frank), among others. In order to track winter extratropical cyclones, we use the maximum relative vorticity at 850 hPa of the new-released long-term ERA-20C reanalysis from the ECMWF since the beginning of the 20th Century until 2010. We develop an automatic procedure to define events. We then quantify the severity of each storm using loss and meteorological indices at country and Europe-wide level. Validation against market losses for the period 1970-2010 is undertaken before considering the severity and frequency of European windstorms for the 110 years period.

  12. European user trial of paging by satellite

    NASA Technical Reports Server (NTRS)

    Fudge, R. E.; Fenton, C. J.

    1990-01-01

    British Telecom conceived the idea of adapting their existing paging service, together with the use of existing terrestrial pagers, to yield a one way data (i.e., paging) satellite service to mobiles. The user trial of paging by satellites was successful. It demonstrated that services could be provided over a wide geographical area to low priced terminals. Many lessons were learned in unexpected areas. These include the need for extensive liaison with all users involved, especially the drivers, to ensure they understood the potential benefits. There was a significant desire for a return acknowledgement channel or even a return data channel. Above all there is a need to ensure that the equipment can be taken across European borders and legitimately used in all European countries. The next step in a marketing assessment would be to consider the impact of two way data messaging such as INMARSAT-C.

  13. Are international securitized property markets converging or diverging?

    NASA Astrophysics Data System (ADS)

    Hui, Eddie C. M.; Chen, Jia; Chan, Ka Kwan Kevin

    2016-03-01

    This study establishes a new framework which combines the recursive model with the Fractionally Integrated Vector Error Correction Model (FIVECM) to investigate the cointegration relationship among 9 securitized real estate indices, which are divided into three groups: Asian, European and North American groups. Our new combined framework has the advantage of reflecting the changes in cointegration dynamics over a period of time instead of a single result for the whole period. The results show that the three groups of markets follow a similar cointegration trend: the cointegration relationship gradually increases before the global financial crisis, reaches a peak during the crisis, and dies down gradually after the crisis. However, cointegration among Asian and European countries occurs at a much later time than cointegration among North American countries does, showing that North America is the source of cointegration, while Asia and Europe are the recipients. This study has important implications to investors and related authorities that investors can adjust their portfolio according to the test results to reduce their risk, while related authorities can take appropriate measures to stabilize the economy and mitigate the effects of financial crises.

  14. Marketing Maps: Illustrating How Marketing Works

    ERIC Educational Resources Information Center

    Gyure, James F.; Arnold, Susan G.

    2003-01-01

    Today's colleges and universities may tolerate the "idea" of marketing more easily, but marketers must continue to educate campus communities about marketing theories and practice. To promote a useful appreciation of how theories translate into initiatives, we propose incorporating "marketing maps"-user-friendly graphic representations of how…

  15. European pharmacovigilance: increasingly outsourced to drug companies.

    PubMed

    2014-12-01

    New regulations reorganising pharmacovigilance at the European level were adopted in late 2010, then revised in 2012 in the wake of the Mediator (benfluorex) disaster. The European Commission's original proposals, released in 2008, would have represented a major step backwards in the protection afforded to European citizens, in particular by facilitating earlier marketing authorisations. Thanks to the mobilisation of civil society, the Members of the European Parliament have improved these proposals, supported by EU health ministers. The role of the new European Pharmacovigilance Risk Assessment Committee (PRAC) has been strengthened. Patients in every Member State have the right to report adverse drug effects directly to health authorities. EU drug regulatory agencies are required to provide greater transparency, and public access to information about adverse effects has been improved. However, one major regression persists: the central role given to pharmaceutical companies in the collection and interpretation of reports of adverse drug effects, despite their conflicts of interest. Drug companies are asked to record the adverse effect reports of which they are aware in a vast European centralised database, Eudravigilance, without going through drug regulatory agencies. Pharmaceutical companies remain responsible for producing "a scientific evaluation of the risk-benefit balance" of their drug, as part of the periodic benefit-risk assessment reports they are required to submit to drug regulatory agencies. These reports are analysed for the entire EU by two Member States (one rapporteur and one co-rapporteur), so that harmonised decisions can be taken. But these decisions are based on data preanalysed by the drug companies. In addition, the independence of the European Medicines Agency is undermined by its financial reliance on the fees paid by pharmaceutical companies in exchange for these assessments. In 2012, following France's Mediator disaster, several modest

  16. Assessing European wild fire vulnerability

    NASA Astrophysics Data System (ADS)

    Oehler, F.; Oliveira, S.; Barredo, J. I.; Camia, A.; Ayanz, J. San Miguel; Pettenella, D.; Mavsar, R.

    2012-04-01

    Wild fire vulnerability is a measure of potential socio-economic damage caused by a fire in a specific area. As such it is an important component of long-term fire risk management, helping policy-makers take informed decisions about adequate expenditures for fire prevention and suppression, and to target those regions at highest risk. This paper presents a first approach to assess wild fire vulnerability at the European level. A conservative approach was chosen that assesses the cost of restoring the previous land cover after a potential fire. Based on the CORINE Land Cover, a restoration cost was established for each land cover class at country level, and an average restoration time was assigned according to the recovery capacity of the land cover. The damage caused by fire was then assessed by discounting the cost of restoring the previous land cover over the restoration period. Three different vulnerability scenarios were considered assuming low, medium and high fire severity causing different levels of damage. Over Europe, the potential damage of wild land fires ranges from 10 - 13, 732 Euro*ha-1*yr-1 for low fire severity, 32 - 45,772 Euro*ha-1*yr-1 for medium fire severity and 54 - 77,812 Euro*ha-1*yr-1 for high fire severity. The least vulnerable are natural grasslands, moors and heathland and sclerophyllous vegetation, while the highest cost occurs for restoring broad-leaved forest. Preliminary validation comparing these estimates with official damage assessments for past fires shows reasonable results. The restoration cost approach allows for a straightforward, data extensive assessment of fire vulnerability at European level. A disadvantage is the inherent simplification of the evaluation procedure with the underestimation of non-markets goods and services. Thus, a second approach has been developed, valuing individual wild land goods and services and assessing their annual flow which is lost for a certain period of time in case of a fire event. However

  17. The new European Hubble archive

    NASA Astrophysics Data System (ADS)

    De Marchi, Guido; Arevalo, Maria; Merin, Bruno

    2016-01-01

    The European Hubble Archive (hereafter eHST), hosted at ESA's European Space Astronomy Centre, has been released for public use in October 2015. The eHST is now fully integrated with the other ESA science archives to ensure long-term preservation of the Hubble data, consisting of more than 1 million observations from 10 different scientific instruments. The public HST data, the Hubble Legacy Archive, and the high-level science data products are now all available to scientists through a single, carefully designed and user friendly web interface. In this talk, I will show how the the eHST can help boost archival research, including how to search on sources in the field of view thanks to precise footprints projected onto the sky, how to obtain enhanced previews of imaging data and interactive spectral plots, and how to directly link observations with already published papers. To maximise the scientific exploitation of Hubble's data, the eHST offers connectivity to virtual observatory tools, easily integrates with the recently released Hubble Source Catalog, and is fully accessible through ESA's archives multi-mission interface.

  18. European EVA decompression sickness risks

    NASA Astrophysics Data System (ADS)

    Vogt, Lorenz; Wenzel, Jürgen; Skoog, A. I.; Luck, S.; Svensson, Bengt

    For the first manned flight of Hermes there will be a capability of performing EVA. The European EVA Space Suit will be an anthropomorphic system with an internal pressure of 500 hPa of pure oxygen. The pressure reduction from the Hermes cabin pressure of 1013 hPa will induce a risk for Decompression Sickness (DCS) for the EVA crewmember if no adequate protective procedures are implemented. Specific decompression procedures have to be developed. From a critical review of the literature and by using knowledge gained from research conducted in the past in the fields of diving and aerospace medicine safe protective procedures are proposed for the European EVA scenario. An R factor of 1.2 and a tissue half-time ( t1/2) of 360 minutes in a single-tissue model have been identified as appropriate operational values. On the basis of an acceptable risk level of approximately 1%, oxygen prebreathing times are proposed for (a) direct pressure reduction from 1013 hPa to a suit pressure of 500 hPa, and (b) staged decompression using a 700 hPa intermediate stage in the spacecraft cabin. In addition, factors which influence individual susceptibility to DCS are identified. Recommendations are also given in the areas of crew selection and medical monitoring requirements together with therapeutic measures that can be implemented in the Hermes scenario. A method for demonstration of the validity of proposed risks and procedures is proposed.

  19. Merging Advertising and PR: Integrated Marketing Communications.

    ERIC Educational Resources Information Center

    Rose, Patricia B.; Miller, Debra A.

    1994-01-01

    Identifies and compares the perceived educational needs of advertising and public relations practitioners. Explores differences between practitioners in small versus large markets, and assesses practitioners' beliefs about integrated marketing communications (the merger of advertising and public relations under a single organizational unit). (SR)

  20. Code of ethics and conduct for European nursing.

    PubMed

    Sasso, Loredana; Stievano, Alessandro; González Jurado, Máximo; Rocco, Gennaro

    2008-11-01

    A main identifying factor of professions is professionals' willingness to comply with ethical and professional standards, often defined in a code of ethics and conduct. In a period of intense nursing mobility, if the public are aware that health professionals have committed themselves to the drawing up of a code of ethics and conduct, they will have more trust in the health professional they choose, especially if this person comes from another European Member State. The Code of Ethics and Conduct for European Nursing is a programmatic document for the nursing profession constructed by the FEPI (European Federation of Nursing Regulators) according to Directive 2005/36/EC On recognition of professional qualifications , and Directive 2006/123/EC On services in the internal market, set out by the European Commission. This article describes the construction of the Code and gives an overview of some specific areas of importance. The main text of the Code is reproduced in Appendix 1.

  1. 800 series bumpers for UK/European markets

    SciTech Connect

    Robinson, F.J.

    1987-01-01

    For the launch of the 800 series ARG set out to maintain the pain on line process for plastic bumpers developed for Maestro and Montego, to achieve this, new and exciting problems had to be overcome. A vehicle weight of 1420kg for the highest derivative, a maximum centreline deflection of 15mm front and rear, a profile collapse calculated to absorb energy within 65% of it's cross sectional area and show no damage within the terms of the ECE 42 regulation, ie 4kph centreline and mounting, 2.5kph corner and a perfect colour match combined with the highest quality.

  2. European Commission activities in eHealth.

    PubMed

    Olsson, Silas; Lymberis, Andreas; Whitehouse, Diane

    2004-12-01

    Health-care is an information-intensive and knowledge-demanding sector, which is why eHealth solutions are so important in this field. The European Commission (EC) has been initiating and funding research and development activities regarding Information and Communication Technologies (ICT) for health, or "eHealth", since 1988. These programmes covered priority topics like electronic health-care records, regional and national health networks, telemedicine in homecare and care-at-the-point-of-need to support continuity of care concepts, systems to support people to stay healthy, and systems and tools to support health professionals to work more efficiently and safely on patients. During the 15-year span of the programmes, the European Union (EU) has contributed about 500 million Euro to approximately 400 R&D projects, support activities, best practice and studies covering technical, clinical, ethical, legal, organisational and market issues. eHealth has shown proven benefits in application fields like improved access to care, care at the point-of-need, citizen-centred care, improved quality and cost containment. Such applications were on show at the EU High Level eHealth Conferences in Brussels, Belgium, in 2003, and in Cork, Ireland, in 2004. eHealth is now on the governmental agenda of EU Member States to be implemented on a broader scale. In line with this development, the Commission has taken a number of policy initiatives. A European Union Action Plan for a European eHealth Area was published by the Commission in April 2004 and endorsed by the EU health ministers in June 2004. This means that, for the first time, Europe has a coherent agenda for the implementation of eHealth. This report will concentrate on eHealth activities initiated by the Information Society Directorate-General of the European Commission.

  3. European Composite Honeycomb Material

    NASA Astrophysics Data System (ADS)

    Tschepe, Christoph; Sauerbrey, Martin; Klebor, Maximillian; Henriksen, Torben

    2014-06-01

    A European CFRP honeycomb material for high demanding structure applications like antenna reflectors and optical benches was developed in the frame of an ESA GSTP project.The composite honeycomb was designed according to requirements defined by the European space industry. A developed manufacturing technique based on prepreg moulding enables the production of homogeneous CFRP honeycomb blocks. All characteristic material properties, including compression, tension and shear strength and CTE, were determined in a comprehensive verification test campaign. Competitiveness to comparable products was further verified by a representative breadboard.

  4. European security and France

    SciTech Connect

    deRose, A.

    1985-01-01

    A French authority on security argues for new European initiatives in the face of the ''danger represented by Soviet military power deployed in support of an imperialistic ideology.'' His proposals, including the strengthening of conventional forces without abandoning the option of the first use of nuclear weapons, are meant to give substance to President Mitterrand's declaration in 1983: ''The European nations now need to realize that their defense is also their responsibility....'' A part of the increasingly important debate in France over defense policy in Europe.

  5. Smart Order Routing Technology in the New European Equity Trading Landscape

    NASA Astrophysics Data System (ADS)

    Ende, Bartholomäus; Gomber, Peter; Lutat, Marco

    In Europe, fragmentation of execution venues has been triggered by increasing competition among markets and a new regulatory environment set up by MiFID. Against this background, IT-based sophisticated order routing systems (Smart Order Routing systems) promise to assure efficiency despite fragmented markets. This raises the question on the relevance and economic value of this technology in European equity trading. Based on order book data for EURO STOXX 50 securities of ten European electronic execution venues, this paper assesses the potential of Smart Order Routing technology by measuring the performance of actual executions in European order book trading relative to a Smart Order Router implementation that detects and accesses best European prices. We identify 6.71% full trade troughs and 6.45% partial trade-throughs in our dataset enabling for significant absolute and relative savings. This indicates that Smart Order Routing technology can provide business value by improving order executions in European cross-tradable equities.

  6. [Harmonisation of the Marketing Authorisation Application dossier: perspectives due to harmonised requirements. Assessing Rules and the Common Technical Document].

    PubMed

    Menges, Klaus

    2008-07-01

    Assessing Rules for Marketing Authorisation Applications and the Common Technical Document provide the framework regarding data-related requirements and regarding the structural requirements of marketing authorisation application dossiers, similar to the structural levels and rooms of buildings on the one hand and their interior equipment on the other hand. Since the 1970s requirements about how to submit application dossiers and how to assess them have become increasingly harmonised, aiming for the use of a single format and identical rules for assessment. In regard of the format, harmonisation has been achieved beyond Europe by implementing the mandatory use of CTD in the three main regions of interests of the pharmaceutical industry, Japan, the United States of America and Europe. The assessment rules have been extensively harmonised throughout Europe in a way that the same rules apply to the marketing authorisation applications submitted in Germany as well as in other Member States. Different interpretations of the guidance documents, different understanding of the provided data or divergent conclusions drawn up may still occur. All stakeholders within the European network of Drug Regulatory Affairs will act on the level floor of the European and--apart from some exceptions--also nationally implemented legislation. This will not only serve the internationally acting pharmaceutical companies' interests but also consumer interests in obtaining consistent information on drug products based on transparent rules safeguarding the necessary pharmaceutical quality, efficacy and safety with respect to an adequate risk-benefit relationship.

  7. A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort

    PubMed Central

    2014-01-01

    Background Genetic modifiers are important clues for the identification of therapeutic targets in neurodegenerative diseases. Huntington disease (HD) is one of the most common autosomal dominant inherited neurodegenerative diseases. The clinical symptoms include motor abnormalities, cognitive decline and behavioral disturbances. Symptom onset is typically between 40 and 50 years of age, but can vary by several decades in extreme cases and this is in part determined by modifying genetic factors. The metabolic master regulator PGC-1α, coded by the PPARGC1A gene, coordinates cellular respiration and was shown to play a role in neurodegenerative diseases, including HD. Methods Using a candidate gene approach we analyzed a large European cohort (n = 1706) from the REGISTRY study for associations between PPARGC1A genotype and age at onset (AO) in HD. Results We report that a coding variant (rs3736265) in PPARGC1A is associated with an earlier motor AO in men but not women carrying the HD mutation. Conclusions These results further strengthen the evidence for a role of PGC-1α in HD and unexpectedly suggest a gender effect. PMID:24383721

  8. [Professional profile and responsibility of the qualified person within the European Union].

    PubMed

    Valverde, J L

    1999-01-01

    The European Community has established a fundamental condition for opening a pharmaceutical laboratory, i.e. the designation of a qualified person having the professional profile detailed in the European Community Directive and who is responsible for implementing specific obligations. It is the final responsibility of this qualified person to release medicine on the market. Do to the importance of this person, we have analyzed his/her functions, obligations and responsibilities. The training required to fulfil the functions of a qualified person is presented. The profiles of qualified persons in the most representative European countries are discussed to demonstrate analogies and differences in national legislations and their adaptation to European Community regulations.

  9. Marketing in nursing organizations.

    PubMed

    Chambers, S B

    1989-05-01

    The purpose of chapter 3 is to provide a conceptual framework for understanding marketing. Although it is often considered to be, marketing is not really a new activity for nursing organizations. What is perhaps new to most nursing organizations is the conduct of marketing activities as a series of interrelated events that are part of a strategic marketing process. The increasingly volatile nursing environment requires a comprehensive approach to marketing. This chapter presents definitions of marketing, the marketing mix, the characteristics of nonprofit marketing, the relationship of strategic planning and strategic marketing, portfolio analysis, and a detailed description of the strategic marketing process. While this chapter focuses on marketing concepts, essential components, and presentation of the strategic marketing process, chapter 4 presents specific methods and techniques for implementing the strategic marketing process.

  10. European Civilization. Teacher's Manual.

    ERIC Educational Resources Information Center

    Leppert, Ella C.; Halac, Dennis

    The instructional materials in this teaching guide for Course II, Unit IV, follow and build upon a previous sequential course described in SO 003 169 offering ninth grade students a study on the development of Western European Civilization. Focus is upon four periods of high development: The High Middle Ages (12th Century), The Renaissance (15th…

  11. The European VLBI network

    NASA Technical Reports Server (NTRS)

    Schilizzi, R. T.

    1980-01-01

    The capabilities of the European very long baseline interferometry (VLBI) network are summarized. The range of baseline parameters, sensitivities, and recording and other equipment available are included. Plans for upgrading the recording facilities and the use of geostationary satellites for signal transfer and clock synchronization are discussed.

  12. European Study Tour Guidelines.

    ERIC Educational Resources Information Center

    Mitchell, Vicki L.; Mitchell, Kenneth E.

    Guidelines are presented for planning and financing European study tours at the community college level. First, a rationale for incorporating study tours of Europe within the community college curriculum is presented and the benefits of such tours in providing students with experiences they could not normally have are outlined. Next, the paper…

  13. European Music Year 1985.

    ERIC Educational Resources Information Center

    Alexanderson, Thomas; And Others

    1984-01-01

    Articles concerning music are included in this newsletter dedicated to cultural venture to be jointly carried out by the Council of Europe and the European communities. Many events will mark Music Year 1985, including concerts, dance performances, operas, publications, recordings, festivals, exhibitions, competitions, and conferences on musical…

  14. Multilingualism in European Workplaces

    ERIC Educational Resources Information Center

    Gunnarsson, Britt-Louise

    2014-01-01

    This state-of-the-art article includes a review of past and recent studies on multilingualism at work in European environments. One aim is to provide the reader with a cross-cultural picture of workplace studies on various languages in Europe, another to discuss both positive and problem-based accounts of multilingualism at work. The overview…

  15. Teaching European Identities

    ERIC Educational Resources Information Center

    Raento, Pauliina

    2008-01-01

    The political, cultural and social make-up of Europe is changing fast. A new European identity is under construction, but old contradictions and diversity challenge its contents, forms and boundaries. Migration, the changing role of the nation-state and Europe's regions, the reshaping of politico-administrative and perceptional boundaries, the…

  16. Marketing II Workbook.

    ERIC Educational Resources Information Center

    Reeves, Cheryl

    This combination curriculum and workbook, which was originally developed for use in a training workshop, is intended to assist adult educators in learning to market their adult literacy programs. The first chapter reviews basic marketing concepts (the definition of marketing, 10 truths about marketing, marketing versus promotion, steps in…

  17. The Market Linkage.

    ERIC Educational Resources Information Center

    Fuchs, Victor E.

    The Market Linkage Project (ML) for Special Education and the Basic Skills Validation and Marketing Program are two federally sponsored marketing projects developed under contract by LINC Resources, Inc., a professional marketing organization, for the U.S. Department of Education. LINC developed the marketing programs to provide the option for the…

  18. Markets for compost

    SciTech Connect

    Not Available

    1993-11-01

    Table of Contents: Introduction; Characteristics and Benefits of Compost and Competing/Complementary Products; Compost Uses and Markets; Factors Pertinent to Developing Compost Markets; Compost Specifications; Compost Testing Requirements; Compost Distribution; Compost Policies; Economic and Noneconomic Barriers to Developing Compost Markets; Strategies to Mitigate/Overcome Barriers to Developing Compost Markets; and Examples of Existing Programs and Markets (as of 1989).

  19. Marketing the College Union.

    ERIC Educational Resources Information Center

    Hoef, Ted; Howe, Nanci

    Theory underlying marketing in the public sector is presented in combination with specific examples of marketing strategies and techniques used in college unions and student activities programs across the country. The subject of marketing is discussed under six major subject headings: (1) why marketing? (2) analyzing marketing opportunities; (3)…

  20. Introduction to Electronic Marketing.

    ERIC Educational Resources Information Center

    Dilbeck, Lettie

    These materials for a five-unit course were developed to introduce secondary and postsecondary students to the use of electronic equipment in marketing. The units cover the following topics: electronic marketing as a valid marketing approach; telemarketing; radio electronic media marketing; television electronic media marketing; and cable TV…

  1. Should Consumers Be Priced Out of Pollution-Permit Markets?

    ERIC Educational Resources Information Center

    Smith, Stefani C.; Yates, Andrew J.

    2003-01-01

    Presents a simple diagrammatic exposition of a pollution-permit market in which firms that generate pollution and consumers who are harmed by pollution are allowed to purchase permits at a single market price. Illustrates that the market equilibrium is efficient only if the endowment of permits is equal to the efficient level of pollution. (JEH)

  2. European option pricing under the Student's t noise with jumps

    NASA Astrophysics Data System (ADS)

    Wang, Xiao-Tian; Li, Zhe; Zhuang, Le

    2017-03-01

    In this paper we present a new approach to price European options under the Student's t noise with jumps. Through the conditional delta hedging strategy and the minimal mean-square-error hedging, a closed-form solution of the European option value is obtained under the incomplete information case. In particular, we propose a Value-at-Risk-type procedure to estimate the volatility parameter σ such that the pricing error is in accord with the risk preferences of investors. In addition, the numerical results of us show that options are not priced in some cases in an incomplete information market.

  3. Marketing through Video Presentations.

    ERIC Educational Resources Information Center

    Newhart, Donna

    1989-01-01

    Discusses the advantages of using video presentations as marketing tools. Includes information about video news releases, public service announcements, and sales/marketing presentations. Describes the three stages in creating a marketing video: preproduction planning; production; and postproduction. (JOW)

  4. International wind farm markets: An overview

    SciTech Connect

    Rackstraw, K.

    1996-12-31

    More wind energy capacity was installed in 1995 than in any previous year. Two markets, Germany and India, accounted for nearly two-thirds of those installations, while the largest single market in the world historically, the US, ground nearly to a halt. Market supports in Germany and India, however, are vulnerable to political forces largely beyond the control of the wind industry. This paper examines the growth of international wind farm markets worldwide and notes that future markets will be more broadly based, leaving the industry less vulnerable to political changes. The paper also concludes that an additional 18,500 MW could be installed by the year 2005 even without assuming a dire ecological scenario that would create environmental drivers to accelerate wind market growth. 4 figs.

  5. Prices dip along with volume. [Uranium market overview - July 1993

    SciTech Connect

    Not Available

    1993-08-01

    The summer doldrums took hold in July, with only eight deals taking place, four on the spot concentrates market, two in conversion and two in enrichment. Spot concentrates volume dropped by 23% to nearly 1.2 million lbs U308 equivalent, resulting in slight declines in NUKEM's restricted and unrestricted price ranges. There were four deals on the spot market in July, totaling nearly 1.2 million lbs U3O8 equivalent. One of the buyers, a US utility, bought low-enriched uranium containing up to 440,000 lbs equivalent. Two of the buyers, a European and a US utility, purchased nearly 580,000 lbs of concentrates, with most going to the European utility. And another US utility bought UF6 containing 149,000 lbs equivalent. As for new demand, four buyers - including the European and US utilities that bought concentrates, as well as an East European utility and a non-US producer - entered the market during the month seeking 1.4 million lbs equivalent. The latter two buyers, along with another European utility and another US utility, are now weighing offers for more than 2.2 million lbs U3O8 equivalent. Looking ahead, we anticipate that as many as 17 buyers may enter the market for nearly 5 million lbs equivalent.

  6. Implications of Carbon Regulation for Green Power Markets

    SciTech Connect

    Bird, Lori; Holt, Ed; Carroll, Ghita

    2007-04-01

    This paper examines the potential effects that emerging mandatory carbon markets have for voluntary markets for renewable energy, or green power markets. In an era of carbon regulation, green power markets will continue to play an important role because many consumers may be interested in supporting renewable energy development beyond what is supported through mandates or other types of policy support. The paper examines the extent to which GHG benefits motivate consumers to make voluntary renewable energy purchases and summarizes key issues emerging as a result of these overlapping markets, such as the implications of carbon regulation for renewable energy marketing claims, the demand for and price of renewable energy certificates (RECs), and the use of RECs in multiple markets (disaggregation of attributes). It describes carbon regulation programs under development in the Northeast and California, and how these might affect renewable energy markets in these regions, as well as the potential interaction between voluntary renewable energy markets and voluntary carbon markets, such as the Chicago Climate Exchange (CCX). It also briefly summarizes the experience in the European Union, where carbon is already regulated. Finally, the paper presents policy options for policymakers and regulators to consider in designing carbon policies to enable carbon markets and voluntary renewable energy markets to work together.

  7. Marketing is everything.

    PubMed

    McKenna, R

    1991-01-01

    Technology is creating customer choice, and choice is altering the marketplace. Gone are the days of the marketer as salesperson. Gone as well is marketing that tries to trick the customer into buying whatever the company makes. There is a new paradigm for marketing, a model that depends on the marketer's knowledge, experience, and ability to integrate the customer and the company. Six principles are at the heart of the new marketing. The first, "Marketing is everything and everything is marketing," suggests that marketing is like quality. It is not a function but an all-pervasive way of doing business. The second, "The goal of marketing is to own the market, not just to sell the product," is a remedy for companies that adopt a limiting "market-share mentality." When you own a market, you lead the market. The third principle says that "marketing evolves as technology evolves." Programmable technology means that companies can promise customers "any thing, any way, any time." Now marketing is evolving to deliver on that promise. The fourth principle, "Marketing moves from monologue to dialogue," argues that advertising is obsolete. Talking at customers is no longer useful. The new marketing requires a feedback loop--a dialogue between company and customer. The fifth principle says that "marketing a product is marketing a service is marketing a product." The line between the categories is fast eroding: the best manufacturing companies provide great service, the best service companies think of themselves as offering high-quality products. The sixth principle, "Technology markets technology," points out the inevitable marriage of marketing and technology and predicts the emergence of marketing workstations, a marketing counterpart to engineers' CAD/CAM systems.

  8. European Union energy policy integration: A case of European Commission policy entrepreneurship and increasing supranationalism

    PubMed Central

    Maltby, Tomas

    2013-01-01

    Focusing on gas, this article explores the role of the European Commission in the process of European Union energy security policy development, and the extent to which the policy area is becoming increasingly supranational. Situating the article within the literature on agenda-setting and framing, it is argued that a policy window was opened as a result of: enlargement to include more energy import dependent states, a trend of increasing energy imports and prices, and gas supply disruptions. From the mid-2000s, the Commission contributed to a shift in political norms, successfully framing import dependency as a problem requiring an EU-level solution, based on the institution’s pre-existing preferences for a diversified energy supply and internal energy market. Whilst Member States retain significant sovereignty, the Commission has achieved since 2006 creeping competencies in the internal, and to a lesser extent external, dimensions of EU energy policy. PMID:24926115

  9. European Union energy policy integration: A case of European Commission policy entrepreneurship and increasing supranationalism.

    PubMed

    Maltby, Tomas

    2013-04-01

    Focusing on gas, this article explores the role of the European Commission in the process of European Union energy security policy development, and the extent to which the policy area is becoming increasingly supranational. Situating the article within the literature on agenda-setting and framing, it is argued that a policy window was opened as a result of: enlargement to include more energy import dependent states, a trend of increasing energy imports and prices, and gas supply disruptions. From the mid-2000s, the Commission contributed to a shift in political norms, successfully framing import dependency as a problem requiring an EU-level solution, based on the institution's pre-existing preferences for a diversified energy supply and internal energy market. Whilst Member States retain significant sovereignty, the Commission has achieved since 2006 creeping competencies in the internal, and to a lesser extent external, dimensions of EU energy policy.

  10. Marketing Online Services: Product, Market and Strategy.

    ERIC Educational Resources Information Center

    Trudell, Libby

    1991-01-01

    Describes characteristics of the online marketplace. Topics discussed include technology barriers; data ownership; markets for online services, including libraries and end users; marketing and promotion tactics, including exhibits and conferences, advertising, direct mail, and user groups; international marketing and service; strategic marketing…

  11. The New European Wind Atlas

    NASA Astrophysics Data System (ADS)

    Lundtang Petersen, Erik

    2013-04-01

    The New European Wind Atlas 1. European wind resource assessment through a ERA-NET Plus project 1.1 The new EU Atlas The Commission decided earlier this year to issue an ERA-NET Plus call for the creation and publication of a new EU wind atlas. The atlas will cover Member states as well as Member states' exclusive economic zones, both onshore and offshore. It involved the launch of a single joint call for proposals by promoters of national and/or regional programmes, thereby allowing a more efficient use of existing financial resources. Therefore the funding scheme is that of ERA-NET Plus which implies that at least 5 MS shall commit at least 1 million Euros each and the Commission tops up with on third of the MS contribution. Basically it is the MS research programmes that will execute the project but an important part of the project is to create "open project development platforms" with associated protocols allowing a wider range of scientists worldwide to contribute. The project has a duration of 5 years. The decision on the new wind atlas was taken after several years of work by the European Wind Energy Technology Platform and the European Energy Research Alliances' Joint programme for Wind Energy. 2. Structure of the project The project will be structured around three areas of work, to be implemented in parallel: 2.1 Creation and publication of a European wind atlas in electronic form, which will include the underlying data and a new EU wind climate database. The database will at a minimum include: Wind resources and their associated uncertainty; Extreme wind; Turbulence characteristics; Adverse weather conditions; Predictability for short term prediction; Guidelines. 2.2 Development of dynamical downscaling methodologies and open-source models. The developed downscaling methodologies and models will be fully documented and made public available and will be used to produce overview maps of wind resources and relevant data at several heights and a horizontal

  12. Mining Marketing Data

    NASA Technical Reports Server (NTRS)

    2002-01-01

    MarketMiner(R) Products, a line of automated marketing analysis tools manufactured by MarketMiner, Inc., can benefit organizations that perform significant amounts of direct marketing. MarketMiner received a Small Business Innovation Research (SBIR) contract from NASA's Johnson Space Center to develop the software as a data modeling tool for space mission applications. The technology was then built into the company current products to provide decision support for business and marketing applications. With the tool, users gain valuable information about customers and prospects from existing data in order to increase sales and profitability. MarketMiner(R) is a registered trademark of MarketMiner, Inc.

  13. Chestnut, European (Castanea sativa).

    PubMed

    Corredoira, Elena; Valladares, Silvia; Vieitez, Ana M; Ballester, Antonio

    2015-01-01

    Development of a system for direct transfer of antifungal candidate genes into European chestnut (Castanea sativa) would provide an alternative approach to conventional breeding for production of chestnut trees that are tolerant to ink disease caused by Phytophthora spp. Overexpression of genes encoding PR proteins (such as thaumatin-like proteins), which display antifungal activity, may represent an important advance in control of the disease. We have used a chestnut thaumatin-like protein gene (CsTL1) isolated from European chestnut cotyledons and have achieved overexpression of the gene in chestnut somatic embryogenic lines used as target material. We have also acclimatized the transgenic plants and grown them on in the greenhouse. Here, we describe the various steps of the process, from the induction of somatic embryogenesis to the production of transgenic plants.

  14. Prospects for European labour demand.

    PubMed

    Lindley, R M

    1988-07-01

    The impact of economic and technological trends upon the level and structure of labor demand is examined, exploring the methods used to model the labor market and making special reference to demography and technology. Evidence on recent and prospective changes in labor demand is reviewed for France, Germany, Italy, the Netherlands, and the UK. The models used to explore future employment scenarios usually fail to incorporate the linkages required to fully analyze the various demographic-economic interactions. Further, this is not generally viewed as a limitation, given the time frame of most employment projections and their preoccupation with changes in the structure of labor demand. Medium-term multisectoral models tend to pay more attention to both demographic and technical change, but the treatment of both aspects is limited. The projections provide a framework for considering how both socioeconomic behavior and policy might change to achieve different outcomes. The greater a model's behavioral content, as expressed in its relationships between different variables, the greater the insight obtainable from simulation exercises. The 1st half of the 1970s was characterized by a reduction in German employment, representing the severest of European reactions to the oil crisis. The 2nd half of the decade recorded rapid growth in Italy and the Netherlands. The 1980s started with marked declines in Germany and the UK. Overall, the net gains of the 1970s were lost in the recession following the 2nd oil crisis. In none of the 5 countries studied does any realistic prospect emerge of achieving full employment before 2000. The most optimistic outcome is that unemployment will decline only slowly, it at all. The growth of both new forms and areas of employment will not compensate sufficiently for the loss of jobs elsewhere and the growth of labor supply. The industrial sector will continue to experience change in favor of the service sector but at a slower rate than during

  15. The European Spallation Source

    SciTech Connect

    Peggs, S; Eshraqi, M; Hahn, H; Jansson, A; Lindroos, M; Ponton, A; Rathsman, K; Trahern, G; Bousso, S; Calaga, R; Devanz, G; Duperrier, R D; Eguia, J; Gammino, S; Moller, S P; Oyon, C; Ruber, R.J.M.Y.; Satogata, T

    2011-03-01

    The European Spallation Source (ESS) is a 5 MW, 2.5 GeV long pulse proton linac, to be built and commissioned in Lund, Sweden. The Accelerator Design Update (ADU) project phase is under way, to be completed at the end of 2012 by the delivery of a Technical Design Report. Improvements to the 2003 ESS design will be summarised, and the latest design activities will be presented.

  16. Education and Labour Market Entry across Europe: The Impact of Institutional Arrangements in Training Systems and Labour Markets. Working Papers = Arbeitspapiere.

    ERIC Educational Resources Information Center

    Gangl, Markus

    Education is the main resource for obtaining employment for young people entering the labor market. European countries differ widely in the institutional structure of their education and training systems and labor markets in that different resources are provided to school-leavers entering into working life in different countries and these new…

  17. A Space for the European Higher Education Area: The Guidance from the EU Court of Justice to Member States

    ERIC Educational Resources Information Center

    Kwikkers, Peter; van Wageningen, Anne

    2012-01-01

    The European Court of Justice has developed a body of jurisprudence that regulates issues such as access, capacity, quality, student allowances and labour market needs, and that should be considered at least an even more important contribution to the European Higher Education Area (EHEA) than the Bologna process. The Bressol and Chaverot cases…

  18. The Changing Place of the University and a Clash of Values: The Entrepreneurial University in the European Knowledge Society

    ERIC Educational Resources Information Center

    Rinne, Risto; Koivula, Jenni

    2005-01-01

    This article reviews literature on changing environment and culture of European universities. First it considers: the pressures of globalisation and knowledge society on universities, the implication of emerging European higher education area, the demands confronting universities, the permeation of the public sector by market ideology and the…

  19. The European Narcolepsy Network (EU-NN) database.

    PubMed

    Khatami, Ramin; Luca, Gianina; Baumann, Christian R; Bassetti, Claudio L; Bruni, Oliviero; Canellas, Francesca; Dauvilliers, Yves; Del Rio-Villegas, Rafael; Feketeova, Eva; Ferri, Raffaele; Geisler, Peter; Högl, Birgit; Jennum, Poul; Kornum, Birgitte R; Lecendreux, Michel; Martins-da-Silva, Antonio; Mathis, Johannes; Mayer, Geert; Paiva, Teresa; Partinen, Markku; Peraita-Adrados, Rosa; Plazzi, Guiseppe; Santamaria, Joan; Sonka, Karel; Riha, Renata; Tafti, Mehdi; Wierzbicka, Aleksandra; Young, Peter; Lammers, Gert Jan; Overeem, Sebastiaan

    2016-06-01

    Narcolepsy with cataplexy is a rare disease with an estimated prevalence of 0.02% in European populations. Narcolepsy shares many features of rare disorders, in particular the lack of awareness of the disease with serious consequences for healthcare supply. Similar to other rare diseases, only a few European countries have registered narcolepsy cases in databases of the International Classification of Diseases or in registries of the European health authorities. A promising approach to identify disease-specific adverse health effects and needs in healthcare delivery in the field of rare diseases is to establish a distributed expert network. A first and important step is to create a database that allows collection, storage and dissemination of data on narcolepsy in a comprehensive and systematic way. Here, the first prospective web-based European narcolepsy database hosted by the European Narcolepsy Network is introduced. The database structure, standardization of data acquisition and quality control procedures are described, and an overview provided of the first 1079 patients from 18 European specialized centres. Due to its standardization this continuously increasing data pool is most promising to provide a better insight into many unsolved aspects of narcolepsy and related disorders, including clear phenotype characterization of subtypes of narcolepsy, more precise epidemiological data and knowledge on the natural history of narcolepsy, expectations about treatment effects, identification of post-marketing medication side-effects, and will contribute to improve clinical trial designs and provide facilities to further develop phase III trials.

  20. [History of the evaluation of medicines aiming for marketing authorization].

    PubMed

    Caulin, C

    2008-01-01

    The European Directive on Medicines Evaluation and Marketing Authorization were issued in 1975. For more than 30 years, Marketing Authorization criteria have been defined as pharmaceutical and biological quality, therapeutic efficacy, and safety. The application comes from the pharmaceutical company and must include the full data on drug development. French procedures have always included practical assessment of the drug by health practitioners: clinicians, pharmacists, biologists, and specialists in biostatistics.

  1. Blueprint of the world`s largest uranium markets

    SciTech Connect

    Bizal, M.R.

    1996-06-01

    This article is a review of two recently released reports: (1) the EURATOM Supply Agency Annual Report for 1995, and (2) the US Energy Information Administration Uranium Industry Annual for 1995. These reports provide myraid information on uranium production, deliveries, contracts, and prices, as well as enrichment market activity during 1995 in the world`s largest nuclear fuel markets: the European Union and the United States.

  2. Energy Savings Certificate Markets: Opportunities and Implementation Barriers

    SciTech Connect

    Friedman, B.; Bird, L.; Barbose, G.

    2009-07-01

    Early experiences with energy savings certificates (ESCs) have revealed their merits and the challenges associated with them. While in the United States ESC markets have yet to gain significant traction, lessons can be drawn from early experiences in the states of Connecticut and New York, as well as from established markets in Italy, France, and elsewhere. The staying power of European examples demonstrates that ESCs can help initiate more efficiency projects. This article compares ESCs with renewable energy certificates (RECs), looks at the unique opportunities and challenges they present, and reviews solutions and best practices demonstrated by early ESC markets. Three major potential ESC market types are also reviewed: compliance, voluntary, and carbon. Additionally, factors that will benefit ESC markets in the United States are examined: new state EEPS policies, public interest in tools to mitigate climate change, and the growing interest in a voluntary market for ESCs.

  3. The European Stroke Organisation Guidelines: a standard operating procedure.

    PubMed

    Ntaios, George; Bornstein, Natan M; Caso, Valeria; Christensen, Hanne; De Keyser, Jacques; Diener, Hans-Christoph; Diez-Tejedor, Exuperio; Ferro, Jose M; Ford, Gary A; Grau, Armin; Keller, Emanuella; Leys, Didier; Russell, David; Toni, Danilo; Turc, Guillaume; Van der Worp, Bart; Wahlgren, Nils; Steiner, Thorsten

    2015-10-01

    In 2008, the recently founded European Stroke Organisation published its guidelines for the management of ischemic stroke and transient ischemic attack. This highly cited document was translated in several languages and was updated in 2009. Since then, the European Stroke Organisation has published guidelines for the management of intracranial aneurysms and subarachnoidal hemorrhage, for the establishment of stroke units and stroke centers, and recently for the management of intracerebral hemorrhage. In recent years, the methodology for the development of guidelines has evolved significantly. To keep pace with this progress and driven by the strong determination of the European Stroke Organisation to further promote stroke management, education, and research, the European Stroke Organisation decided to delineate a detailed standard operating procedure for its guidelines. There are two important cornerstones in this standard operating procedure: The first is the implementation of the Grading of Recommendations Assessment, Development, and Evaluation methodology for the development of its Guideline Documents. The second one is the decision of the European Stroke Organisation to move from the classical model of a single Guideline Document about a major topic (e.g. management of ischemic stroke) to focused modules (i.e. subdivisions of a major topic). This will enable the European Stroke Organisation to react faster when new developments in a specific stroke field occur and update its recommendations on the related module rather swiftly; with the previous approach of a single large Guideline Document, its entire revision had to be completed before an updated publication, delaying the production of up-to-date guidelines. After discussion within the European Stroke Organisation Guidelines Committee and significant input from European Stroke Organisation members as well as methodologists and analysts, this document presents the official standard operating procedure for

  4. [The drug trade between European countries and developing countries].

    PubMed

    Bruneton, C; Naboulet, P; van der Heide, B; Rey, J L

    1997-01-01

    The quality of medicinal products marketed in developing countries has recently become the focus of lively debate and new interest. This report describes a survey conducted among officials from exporting and importing countries designed to evaluate the content and enforcement of current regulations. Resulting data indicated that, despite the high volume of trading in medicinal products between European and developing countries, regulations are poorly applied and many infractions occur. The most obvious abnormalities involve definition of market status. A list of banned is issued by the WHO but not by the European Economic Community. Regulations regarding generic products differ from one country to another and, since determination of the exact origin of a product may be difficult, compliance with good manufacturing practices is often unverifiable. A more cooperative attitude on the part of exporting countries and standardization of formalities on the part of importing countries will be necessary to stem the growing tendency to consider medicinal products as ordinary goods.

  5. The role of the European court of justice in the Europeanization of communicable disease control: driver or irrelevance?

    PubMed

    Hervey, Tamara

    2012-12-01

    What role(s) does the European Court of Justice (ECJ) play in the Europeanization of communicable disease control? Drawing on a review of the ECJ's case law, especially but not exclusively in public health fields, from the 1950s to 2009, this article argues that the ECJ's past and present role in the Europeanization of communicable disease control is neither that of a driver nor that of an irrelevance. Instead, the ECJ has been responsible for four important elements of the environment that over time led to the Europeanization of communicable disease control in general and the establishment of the European Centre for Disease Prevention and Control in particular: (1) the European Union itself has responsibility for public health; (2) agencies are a constitutionally permissible institutional arrangement in the EU; (3) EU legislation that inter alia protects public health is mandatory and justiciable; and (4) such EU legislation may not be undermined by liberalizing internal market law. A fifth idea, "mainstreaming" public health, could play a role in the future.

  6. European small geostationary communications satellites

    NASA Astrophysics Data System (ADS)

    Sun, Wei, , Dr.; Ellmers, Frank; Winkler, Andreas; Schuff, Herbert; Sansegundo Chamarro, Manuel Julián

    2011-04-01

    Hispasat Advanced Generation 1 (HAG1) is the first satellite using the SGEO platform, which is under the development in the ESA Artes-11 program. Since the last presentation in the IAC 2007, a European industrial consortium led by OHB has completed the mission and spacecraft design. The platform Preliminary Design Review has been carried out in May 2008. The customer for the first mission is a commercial operator—Hispasat. The contract was signed in December 2008 and the satellite will be launched in 2012. To give confidence to the customer, SGEO platform will use up to date flight proven technologies. HAG1 carries 20/24 Ku-band and 3/5 Ka-band transponders to provide commercial services. Some innovative payload technologies will also be flown on board of HAG1 to gain in-orbit heritage. SGEO has also been selected as the baseline platform for the ESA Data Relay Satellite (EDRS). Phase-A study has just kicked off in January 2009. The targeted launch date is 2013. Heinrich Hertz will also use the SGEO platform. Heinrich Hertz is funded by the German Space Agency (DLR) and provides flight opportunities for technologies and components developed by the German Space Industry. With the HAG1 contract in hand, and EDRS and Heinrich Hertz in the line, OHB with its partners has the confidence that it will be able to speed up the product development of the SGEO platform for potential customers in the commercial market. This paper will first present the updated platform design and the status of the product development will be followed with the introduction of innovative payload technologies on board the first mission—HAG1 and ended with the mission concepts of EDRS and Heinrich Hertz missions.

  7. Veterinary practice marketeer.

    PubMed

    Phillips, Justin

    2015-01-24

    Justin Phillips is marketing manager at White Cross Vets and the Veterinary Marketing Association's (VMA's) Young Veterinary Marketeer of the Year. Here, he describes what he does and why he believes other practices should embrace marketing to improve their quality and client care.

  8. Cooperative Market Research Project.

    ERIC Educational Resources Information Center

    Carels, Peter; McCullough, Lynette

    A pilot project was developed in which the Advertising and Market Research Center of the Vienna School of Economics and Business in Austria and the German Department as well as the Marketing Department of Miami University in Ohio are working together to collect market research data and formulate a market entry strategy for Roemerquelle, an…

  9. Markets for recovered aluminum

    SciTech Connect

    Not Available

    1993-04-01

    The study describes the operation of the markets for scrap aluminum as an example of how recycling markets are structured, what factors influence the supply of and demand for materials, what projections can be made about recycling markets, and how government policies to increase recycling may affect these markets.

  10. Market review - Market values summary/August market review/current market data

    SciTech Connect

    1995-09-01

    This article is the August 1995 uranium market review. During this reporting period, there were three transactions in the long-term concentrates sector, no transactions in the UF6 market, and limited activity in the spot conversion market and the enrichment services market. Active supply rose, as did active demand. Prices were stable to slightly increasing.

  11. Marketing Human Resource Development.

    ERIC Educational Resources Information Center

    Frank, Eric, Ed.

    1994-01-01

    Describes three human resource development activities: training, education, and development. Explains marketing from the practitioners's viewpoint in terms of customer orientation; external and internal marketing; and market analysis, research, strategy, and mix. Shows how to design, develop, and implement strategic marketing plans and identify…

  12. Hospital marketing revisited.

    PubMed

    Costello, M M

    1987-05-01

    With more hospitals embracing the marketing function in their organizational management over the past decade, hospital marketing can no longer be considered a fad. However, a review of hospital marketing efforts as reported in the professional literature indicates that hospitals must pay greater attention to the marketing mix elements of service, price and distribution channels as their programs mature.

  13. Strategic Marketing for Agribusiness.

    ERIC Educational Resources Information Center

    Welch, Mary A., Ed.

    1993-01-01

    The steps for strategic market planning are discussed including: (1) assessing the situation with market conditions, customers, competitors, and your firm; and (2) crafting a strategy to prioritize target markets, develop a core strategy, and create a marketing mix. Examples of agribusiness successes are presented. The booklet concludes with a…

  14. Marketing the pathology practice.

    PubMed

    Berkowitz, E N

    1995-07-01

    Effective marketing of the pathology practice is essential in the face of an increasingly competitive market. Successful marketing begins with a market-driven planning process. As opposed to the traditional planning process used in health care organizations, a market-driven approach is externally driven. Implementing a market-driven plan also requires recognition of the definition of the service. Each market to which pathologists direct their service defines the service differently. Recognition of these different service definitions and creation of a product to meet these needs could lead to competitive advantages in the marketplace.

  15. Marketing your expertise.

    PubMed

    Czaplewski, L M

    1999-01-01

    Marketing an existing or new venture is a vital part of business. For the nurse entrepreneur, marketing involves applying previously learned skills to new situations. The methods used to market a service may mean the difference between success and failure. Unfortunately many entrepreneurs think that because they have a great idea, clients will beat a path to their door. Marketing requires planning, creativity, time, and money. It is an ongoing process that must be evaluated regularly. When marketing achieves results, clients commit to using the entrepreneur's services and profits are realized. Basic marketing concepts are considered, and strategies for developing a workable marketing plan are presented.

  16. [CHALLENGES OF THE NURSING PROFESSION AT EUROPEAN LEVEL].

    PubMed

    Bereciartu Martínez, Griselda

    2015-11-01

    Professional nurses are internationally sought after, a fact reinforced under the frames of exchange and cooperation promoted by the European Union. Given the high percentage of mobility shown by health professionals, nurses need a thorough preparation to facilitate their integration in the countries where they are likely to develop their professional careers. In order to promote exchange and facilitate discussion between nurses from different European countries, the Health School of the Polytechnic Institute of Portalegre (Portugal), organized on the 2nd and 3rd of September the International Health Sciences Meeting ESS 2015 ("Promoting bonds - A newchallenge for the future ofhealth professions in Europe"). The diverse working conditions that nurses are faced with in different countries highlight the need to foster awareness of the profession at European level, facilitating ties, exchange and scientific platforms to address the current reality of the labor market.

  17. Wind offering in energy and reserve markets

    NASA Astrophysics Data System (ADS)

    Soares, T.; Pinson, P.; Morais, H.

    2016-09-01

    The increasing penetration of wind generation in power systems to fulfil the ambitious European targets will make wind power producers to play an even more important role in the future power system. Wind power producers are being incentivized to participate in reserve markets to increase their revenue, since currently wind turbine/farm technologies allow them to provide ancillary services. Thus, wind power producers are to develop offering strategies for participation in both energy and reserve markets, accounting for market rules, while ensuring optimal revenue. We consider a proportional offering strategy to optimally decide upon participation in both markets by maximizing expected revenue from day-ahead decisions while accounting for estimated regulation costs for failing to provide the services. An evaluation of considering the same proportional splitting of energy and reserve in both day- ahead and balancing market is performed. A set of numerical examples illustrate the behavior of such strategy. An important conclusion is that the optimal split of the available wind power between energy and reserve strongly depends upon prices and penalties on both market trading floors.

  18. A Marketing Case History Profile

    ERIC Educational Resources Information Center

    Weirick, Margaret C.

    1978-01-01

    A current marketing plan from Temple University illustrates many marketing techniques, including those dealing with enrollment objectives, market objectives, demographic characteristics of Temple students, market share analysis, and the marketing plan. Specific guidelines are provided. (LBH)

  19. The role of bioethics in the international prescription drug market: economics and global justice.

    PubMed

    Newland, Shelby E

    2006-01-01

    In terms of health care access, bioethics has an important role to inform and shape policy issues and develop interdisciplinary ideas and interventions. The rising price of prescription drugs presents one of the most looming barriers to health care access in the world today. Including both theoretical and practical features of the pharmaceutical industry's behavior is necessary to find ethical solutions towards increasing access. Bioethics can evaluate global justice by weighing human rights theory and future innovation at the macro level, and by addressing market forces and responsibilities at the micro level. Inherent structural features of pharmaceuticals, such as its reliance on research and development, cause the industry to employ pricing strategies that seem counter-intuitive to conventional wisdom, but that result in producing a just allocation as defined by market forces. Parallel trade and drug exportation/reimportation threaten the saliency of the industry's differential pricing scheme; a case-study of a single "Euro-price" within the European Union illustrates how this will actually create harm to the most needy member states. This complex situation requires solutions weighing arguments from human rights theory with those from economic theory to arrive at the most globally just allocation of prescription drugs in the global marketplace, as well as to ensure future innovation and scientific progress. Bioethicists as well as economists need to partake urgently in this discourse for the betterment of the global injustices in the international prescription drug market.

  20. Eastern European risk management

    SciTech Connect

    Honey, J.A. )

    1992-01-01

    Here the authors assess Eastern European risk management practices through the evaluation of the nuclear power plants in the region. This evaluation is limited to the Soviet-designed and -built VVER-440 pressurized water reactors (PWRs) that are currently operating in Bulgaria, Czechoslovakia, Hungary, Russia, and the Ukraine and until recently operated at Greifswald in the former East Germany. This evaluation is based on the basic design of the plants, a safety evaluation of the Greifswald facility by representatives from the Federal Republic of Germany and personal visits by the author to Greifswald and Loviisa.

  1. [Orphan diseases and orphan medicines: a Belgian and European study].

    PubMed

    Denis, Alain; Mergaert, Lut; Fostier, Christel; Cleemput, Irina; Simoens, Steven

    2009-12-01

    The objective of this study is to analyze policies concerning orphan medicines, used to treat patients suffering from a rare disease. The decisions about orphan designation and marketing authorization of orphan medicines are taken at European level, but each Member State is responsible for decisions regarding reimbursement. The European measures to encourage the development of orphan medicines, such as market exclusivity for a period of ten years, seem to be successful. However, this market exclusivity should be revised once the profitability of such medicines has clearly been demonstrated. Our study recommends the implementation of patient registries at the European level in order to describe the natural evolution of rare diseases and the efficacy of orphan medicines, the majority of which are relatively expensive. In 2008, Belgian social security services reimbursed orphan medicines for an amount of 66 million euro, accounting for more than 5% of the hospital pharmaceutical budget. The reimbursement of an orphan medicine to an individual patient is subject to multiple conditions. Our study recommends that a unique counter within the NIHDI is created which centralizes all reimbursement requests. The reimbursement of an orphan medicine must be linked to the provision of standardized information needed for a patient register. The NIHDI administration could then, in collaboration with external experts, evaluate reimbursement requests and ensure a coherent application of reimbursement criteria.

  2. Marketing-oriented organizations: an integrated approach.

    PubMed

    Stensrud, R; Arrington, B

    1988-03-01

    Organizations can be oriented toward marketing from a production, product, sales, or marketing perspective. Strategies, structures, and cultures, which reflect a company's basic orientation, must be integrated to ensure that marketing efforts communicate a clear corporate position. In a study of 31 hospitals, the Center for Health Services Education Research, St. Louis University, found that no hospital's organization fit neatly into a single category. For example, a hospital may have some service lines that were marketing oriented while other lines were production oriented. The majority of hospitals, however, were product oriented, focusing on productivity and financial performance rather than on market factors. The most effective sales orientation was observed in the for-profits. Their selling efforts, however, tended to be internally focused, with product development activities divorced from the planning and marketing functions. Only the for-profit hospitals showed the beginning of a marketing orientation. Developing a marketing orientation, especially in line divisions, requires a careful, well-orchestrated effort and the presence of several key factors: Access to capital and an emphasis on long-range planning and strategic spending The availability of hospital-specific market research. Key distribution channels. Talented middle managers. Up-to-date systems and structures equipped to serve new values and strategies. Leaders capable of communicating to the organization a vision of its role in the community.

  3. A quantitative description for efficient financial markets

    NASA Astrophysics Data System (ADS)

    Immonen, Eero

    2015-09-01

    In this article we develop a control system model for describing efficient financial markets. We define the efficiency of a financial market in quantitative terms by robust asymptotic price-value equality in this model. By invoking the Internal Model Principle of robust output regulation theory we then show that under No Bubble Conditions, in the proposed model, the market is efficient if and only if the following conditions hold true: (1) the traders, as a group, can identify any mispricing in asset value (even if no one single trader can do it accurately), and (2) the traders, as a group, incorporate an internal model of the value process (again, even if no one single trader knows it). This main result of the article, which deliberately avoids the requirement for investor rationality, demonstrates, in quantitative terms, that the more transparent the markets are, the more efficient they are. An extensive example is provided to illustrate the theoretical development.

  4. A predominantly neolithic origin for European paternal lineages.

    PubMed

    Balaresque, Patricia; Bowden, Georgina R; Adams, Susan M; Leung, Ho-Yee; King, Turi E; Rosser, Zoë H; Goodwin, Jane; Moisan, Jean-Paul; Richard, Christelle; Millward, Ann; Demaine, Andrew G; Barbujani, Guido; Previderè, Carlo; Wilson, Ian J; Tyler-Smith, Chris; Jobling, Mark A

    2010-01-19

    The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in frequency from east to west, and carried by 110 million European men. Previous studies suggested a Paleolithic origin, but here we show that the geographical distribution of its microsatellite diversity is best explained by spread from a single source in the Near East via Anatolia during the Neolithic. Taken with evidence on the origins of other haplogroups, this indicates that most European Y chromosomes originate in the Neolithic expansion. This reinterpretation makes Europe a prime example of how technological and cultural change is linked with the expansion of a Y-chromosomal lineage, and the contrast of this pattern with that shown by maternally inherited mitochondrial DNA suggests a unique role for males in the transition.

  5. A Predominantly Neolithic Origin for European Paternal Lineages

    PubMed Central

    Balaresque, Patricia; Bowden, Georgina R.; Adams, Susan M.; Leung, Ho-Yee; King, Turi E.; Rosser, Zoë H.; Goodwin, Jane; Moisan, Jean-Paul; Richard, Christelle; Millward, Ann; Demaine, Andrew G.; Barbujani, Guido; Previderè, Carlo; Wilson, Ian J.; Tyler-Smith, Chris; Jobling, Mark A.

    2010-01-01

    The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in frequency from east to west, and carried by 110 million European men. Previous studies suggested a Paleolithic origin, but here we show that the geographical distribution of its microsatellite diversity is best explained by spread from a single source in the Near East via Anatolia during the Neolithic. Taken with evidence on the origins of other haplogroups, this indicates that most European Y chromosomes originate in the Neolithic expansion. This reinterpretation makes Europe a prime example of how technological and cultural change is linked with the expansion of a Y-chromosomal lineage, and the contrast of this pattern with that shown by maternally inherited mitochondrial DNA suggests a unique role for males in the transition. PMID:20087410

  6. 75 FR 4100 - Affirmative Fair Housing, Marketing (AFHM) Plan-Multifamily Housing, Affirmative Fair Housing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... URBAN DEVELOPMENT Affirmative Fair Housing, Marketing (AFHM) Plan-Multifamily Housing, Affirmative Fair Housing Marketing (AFHM) Plan-Single Family Housing and Affirmative Fair Housing Marketing (AFHM) Plan... forms to describe their intent for marketing to ensure that they meet the Fair Housing...

  7. Payloads development for European land mobile satellites: A technical and economical assessment

    NASA Technical Reports Server (NTRS)

    Perrotta, G.; Rispoli, F.; Sassorossi, T.; Spazio, Selenia

    1990-01-01

    The European Space Agency (ESA) has defined two payloads for Mobile Communication; one payload is for pre-operational use, the European Land Mobile System (EMS), and one payload is for promoting the development of technologies for future mobile communication systems, the L-band Land Mobile Payload (LLM). A summary of the two payloads and a description of their capabilities is provided. Additionally, an economic assessment of the potential mobile communication market in Europe is provided.

  8. Market assessment overview

    NASA Technical Reports Server (NTRS)

    Habib-Agahi, H.

    1981-01-01

    Market assessment, refined with analysis disaggregated from a national level to the regional level and to specific market applications, resulted in more accurate and detailed market estimates. The development of an integrated set of computer simulations, coupled with refined market data, allowed progress in the ability to evaluate the worth of solar thermal parabolic dish systems. In-depth analyses of both electric and thermal market applications of these systems are described. The following market assessment studies were undertaken: (1) regional analysis of the near term market for parabolic dish systems; (2) potential early market estimate for electric applications; (3) potential early market estimate for industrial process heat/cogeneration applications; and (4) selection of thermal and electric application case studies for fiscal year 1981.

  9. Is European Defense a Bridge too Far?

    DTIC Science & Technology

    2006-03-08

    Defense, European Security and Defense Policy (ESDP) CLASSIFICATION: Unclassified During the last several decades the European Union has not paid much...obvious European defense shortcomings. Then, after the Cologne European Council of June 1999, the European Union launched the European Security and...considerably and the military capabilities of the European Union have been strengthened with initiatives such as the battlegroup concept and the development of

  10. The Changing Legal Climate for Marketing and Advertising in Europe.

    ERIC Educational Resources Information Center

    Dunn, S. Watson

    Although advertisers and marketers can expect stronger controls in all West European countries, especially by governments, they must be alert to country-by-country differences. Political moves to the left in any country will hasten controls. Consumerism is militant in some countries, practically dormat in others. Although self regulation is strong…

  11. The Portuguese Youth Labour Market: A Critical Approach

    ERIC Educational Resources Information Center

    Tome, Eduardo

    2008-01-01

    Purpose: The aim of this paper is to analyse critically the youth labour market (YLM) and the YLM policies in Portugal. The analysis covers essentially the period after 1986, when Portugal entered the European Union. Design/methodology/approach: The paper consists of three main sections. In the first the main players dealt with (government,…

  12. Model of Learning for Career and Labour Market Transitions

    ERIC Educational Resources Information Center

    Brown, Alan; Bimrose, Jenny

    2014-01-01

    The study, upon which this special issue focuses, used narrative interviews to investigate how learning can support workers' transitions in the labour market in five European countries (Denmark, France, Germany, Italy and Spain). The five countries were chosen to represent very different contexts in the way learning can support career and labour…

  13. EU Regulations Impede Market Introduction of GM Forest Trees.

    PubMed

    Custers, René; Bartsch, Detlef; Fladung, Matthias; Nilsson, Ove; Pilate, Gilles; Sweet, Jeremy; Boerjan, Wout

    2016-04-01

    Biotechnology can greatly improve the efficiency of forest tree breeding for the production of biomass, energy, and materials. However, EU regulations impede the market introduction of genetically modified (GM) trees so their socioeconomic and environmental benefits are not realized. European policy makers should concentrate on a science-based regulatory process.

  14. The Problem of a Market-Oriented University

    ERIC Educational Resources Information Center

    Hayrinen-Alestalo, Marja; Peltola, Ulla

    2006-01-01

    Economy- and technology-driven theories dominate current explanations of social change. The political orientations of the European Union and many of its member states are increasingly based on the idea of knowledge economy where public organisations move towards market-orientation. Among the other producers of knowledge, universities are expected…

  15. 7 CFR 1218.11 - Market or marketing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Market or marketing. 1218.11 Section 1218.11 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Market or marketing. (a) Marketing means the sale or other disposition of blueberries in any channel...

  16. 7 CFR 1208.12 - Market or marketing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Market or marketing. 1208.12 Section 1208.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... § 1208.12 Market or marketing. (a) Marketing means the sale or other disposition of processed...

  17. 7 CFR 1218.11 - Market or marketing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Market or marketing. 1218.11 Section 1218.11 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Market or marketing. (a) Marketing means the sale or other disposition of blueberries in any channel...

  18. 7 CFR 1218.11 - Market or marketing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Market or marketing. 1218.11 Section 1218.11 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Market or marketing. (a) Marketing means the sale or other disposition of blueberries in any channel...

  19. 7 CFR 1218.11 - Market or marketing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Market or marketing. 1218.11 Section 1218.11 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Market or marketing. (a) Marketing means the sale or other disposition of blueberries in any channel...

  20. 7 CFR 1208.12 - Market or marketing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Market or marketing. 1208.12 Section 1208.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... § 1208.12 Market or marketing. (a) Marketing means the sale or other disposition of processed...

  1. 7 CFR 1206.12 - Market or marketing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Market or marketing. 1206.12 Section 1206.12... INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.12 Market or marketing. Marketing means the sale or other disposition of mangos in the U.S. domestic market. To market means to...

  2. The European lead/acid battery industry

    NASA Astrophysics Data System (ADS)

    Claudel, J. L.

    The European lead/acid battery industry is examined from a general perspective that covers wide economic, industrial and technical issues. It would appear that the upheavals witnessed in Eastern Europe two years ago together with the more recent political and monetary events throw two points into sharp relief: first, the merely relative value of general speeches, that are liable to sound technocratic and out of touch with the realities of the world; second, the need for an industrialist to be able to stand back and view things from a distance. Given this background, the review is divided into four parts, namely: (i) general remarks about Europe; (ii) the wider context of the lead/acid battery industry; (iii) changes in demand; (iv) structural changes in market supply. Finally, a number of observations are made about the key issues that will prove decisive for the future of battery manufacturers in Europe within the context of a rapidly changing environment.

  3. Clinical validation protocols for noninvasive blood pressure monitors and their recognition by regulatory authorities and professional organizations: rationale and considerations for a single unified protocol or standard.

    PubMed

    Ng, Kim-Gau

    2013-10-01

    Standardized protocols for validating the clinical accuracy of noninvasive blood pressure (NIBP) monitors have been available since 1987. Some of them were developed by standards bodies and others by professional organizations. They have been well-tested through use and progressively improved through multiple revisions; however, many methodological differences exist between them. In addition, for the purpose of regulatory approval or marketing clearance, some protocols are recognized in some countries but not in others; thus, manufacturers have to validate their NIBP monitors to more than one protocol in order to market them worldwide. The use of different protocols not only makes it difficult to compare one device with another but also complicates the validation, regulatory approval, marketing, and public acceptance of NIBP monitors, creating undue burden on manufacturers and unnecessary confusion among users. There is a need for protocol developers, standards bodies, and regulatory authorities to work together to develop and agree on a single unified protocol or standard, one that builds on the strengths of the various protocols that have been developed so far. It is apparent that there is already a trend toward convergence of the various protocols into two protocols, namely, the ISO 81060-2:2009 standard and the 2010 European Society of Hypertension International Protocol. With further reconciliation and consensus, it should be possible to integrate the best features of the ISO, European Society of Hypertension, and other protocols, along with further improvements, into a single unified protocol or standard.

  4. A New Impetus for European Youth. European Commission White Paper.

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium).

    Despite their highly divergent situations, young people largely share the same values, ambitions, and difficulties. Despite the more complex social and economic context in which young Europeans are currently living, they are well equipped to adapt. National and European policymakers must facilitate this process of change by making young people…

  5. Medical devices manufactured from latex: European regulatory initiatives.

    PubMed

    De Jong, W H; Geertsma, R E; Tinkler, J J B

    2002-05-01

    In Europe the marketing of medical devices manufactured from latex is regulated by directives describing the essential (safety) requirements that products have to fulfill to obtain marketing approval. This paper describes the general requirements for marketing medical devices in Europe and, more specifically, the requirements for products manufactured from natural rubber latex. The requirements for marketing medical devices can be fulfilled by using the relevant harmonized European standards. These standards are regularly under revision to incorporate the latest scientific developments. For certain devices, for example, latex medical (examination and surgical) gloves, specific standards have been published. Medical devices manufactured from latex pose a serious problem because of the risk of induction of allergy both against the latex proteins inherently present (type I or immediate type allergy) and against chemicals added during processing (type IV or delayed type hypersensitivity) present as residues in the latex products. So, besides requirements for product quality in terms of barrier properties, strength, and sterility, the main focus consists of the allergy-inducing properties of the latex products. Recent developments have reopened the discussion on the value of total protein versus allergen determination in latex medical gloves. However, as long as minimal levels needed for both sensitization and elicitation have not been established, a safe maximum level for leachable proteins/allergens in latex products cannot be determined. A European Commission guidance document on the latex allergy problem is currently being drafted by experts from Competent Authorities.

  6. Analysis of the Italian generic medicines retail market: recommendations to enhance long-term sustainability.

    PubMed

    Dylst, Pieter; Vulto, Arnold; Simoens, Steven

    2015-02-01

    Italy is among the European countries with the lowest uptake of generic medicines. This paper provides a perspective on the Italian generic medicines retail market. Fast market entrance of generic medicines in Italy is hindered by several factors: the existence of Complementary Protection Certificates in the past, the large market for copies and multiple cases of patent linkage. Prices of generic medicines in Italy are low compared to other European countries. To contain pharmaceutical expenditure, pharmaceutical companies are currently forced to pay back in case of overspending, which disproportionally penalizes small and fast growing companies, to which most generic companies belong to. Current demand-side policies do not successfully stimulate the use of generic medicines. The current market environment surrounding the Italian generic medicines retail market (i.e., low prices, low volumes) threatens its long-term sustainability. Recommendations to enhance the long-term sustainability of the Italian generic medicines retail market round off this perspective paper.

  7. Satellite broadcasting - The European experience and perspective

    NASA Astrophysics Data System (ADS)

    Watson, Alan

    1991-11-01

    The use of satellites is considered as a means for developing a European transnational broadcasting system with attention given to the control of technology. A tension is described between maintaining technology as the property of one nation when the DBSs are developed for multinational program broadcasting. The simultaneous development of satellite systems is theorized to lead eventually to a single merged program for a particular nation, and the effect is considered of the regulation of cross-holding and cross-selling systems by investors.

  8. Market power in auction and efficiency in emission permits allocation.

    PubMed

    Jiang, Min Xing; Yang, Dong Xiao; Chen, Zi Yue; Nie, Pu Yan

    2016-12-01

    This paper analyzes how to achieve the cost-effectiveness by initial allocation of CO2 emission permits when a single dominant firm in production market has market power in auction, and compare two prevalent allocation patterns, mixed allocation and single auction. We show how the firm with market power may manipulate the auction price, thereby this leads to fail to achieve cost-effective solution by auction unless the total permits for allocation equal to the effective emissions cap. Provided that the market power firm receives strictly positive free permits, the effective emissions cap of mixed allocation is larger than that of single auction. The production market share of dominant firm is increasing with the free permits it holds. Finally, we examine the compliance costs and welfare of mixed allocation and single auction, the result show that the former is preferred to the later when policy makers consider economic welfare without welfare cost due to CO2 emissions.

  9. Refugee blues: a UK and European perspective

    PubMed Central

    Turner, Stuart

    2015-01-01

    In this paper, the numbers of refugees travelling to the European Union are set in a global context. It is argued that the increasing restrictions placed on asylum seekers from the 1980s onwards in the UK and the associated culture of deterrence and prohibition have had the perverse effect of supporting the economic market for people smuggling. It appears that these restrictions were initially designed to deter people, most of whom would have been granted humanitarian assistance had they managed to arrive in the UK, so as to prevent them from accessing the decision-making process on asylum. Policy changes concerning travel, benefits, and other pressures on asylum seekers are also considered in the context of deterrence. The problems facing asylum seekers do not end with their arrival in a safe country. The current methods of determining refugee status are alarmingly weak. Indeed there is evidence suggesting that those who are most traumatised before arrival face systematic disadvantage. The focus of this paper is on the United Kingdom but its conclusions apply to most Western European countries. The paper concludes with some tentative suggestions for change. PMID:26514159

  10. Refugee blues: a UK and European perspective.

    PubMed

    Turner, Stuart

    2015-01-01

    In this paper, the numbers of refugees travelling to the European Union are set in a global context. It is argued that the increasing restrictions placed on asylum seekers from the 1980s onwards in the UK and the associated culture of deterrence and prohibition have had the perverse effect of supporting the economic market for people smuggling. It appears that these restrictions were initially designed to deter people, most of whom would have been granted humanitarian assistance had they managed to arrive in the UK, so as to prevent them from accessing the decision-making process on asylum. Policy changes concerning travel, benefits, and other pressures on asylum seekers are also considered in the context of deterrence. The problems facing asylum seekers do not end with their arrival in a safe country. The current methods of determining refugee status are alarmingly weak. Indeed there is evidence suggesting that those who are most traumatised before arrival face systematic disadvantage. The focus of this paper is on the United Kingdom but its conclusions apply to most Western European countries. The paper concludes with some tentative suggestions for change.

  11. European Cenozoic rift system

    NASA Astrophysics Data System (ADS)

    Ziegler, Peter A.

    1992-07-01

    The European Cenozoic rift system extends from the coast of the North Sea to the Mediterranean over a distance of some 1100 km; it finds its southern prolongation in the Valencia Trough and a Plio-Pleistocene volcanic chain crossing the Atlas ranges. Development of this mega-rift was paralleled by orogenic activity in the Alps and Pyrenees. Major rift domes, accompanied by subsidence reversal of their axial grabens, developed 20-40 Ma after beginning of rifting. Uplift of the Rhenish Shield is related to progressive thermal lithospheric thinning; the Vosges-Black Forest and the Massif Central domes are probably underlain by asthenoliths emplaced at the crust/mantle boundary. Evolution of this rift system, is thought to be governed by the interaction of the Eurasian and African plates and by early phases of a plate-boundary reorganization that may lead to the break-up of the present continent assembly.

  12. An American Construction of European Education Space

    ERIC Educational Resources Information Center

    Silova, Iveta; Brehm, William C.

    2010-01-01

    The construction of the European education space has typically been attributed to European education policy makers, institutions, and networks. Rarely do scholars consider the role of outside, non-European actors in shaping the terrain of European education thought and practice. This article considers the construction of the European education…

  13. Measuring capital market efficiency: Global and local correlations structure

    NASA Astrophysics Data System (ADS)

    Kristoufek, Ladislav; Vosvrda, Miloslav

    2013-01-01

    We introduce a new measure for capital market efficiency. The measure takes into consideration the correlation structure of the returns (long-term and short-term memory) and local herding behavior (fractal dimension). The efficiency measure is taken as a distance from an ideal efficient market situation. The proposed methodology is applied to a portfolio of 41 stock indices. We find that the Japanese NIKKEI is the most efficient market. From a geographical point of view, the more efficient markets are dominated by the European stock indices and the less efficient markets cover mainly Latin America, Asia and Oceania. The inefficiency is mainly driven by a local herding, i.e. a low fractal dimension.

  14. Correlations of multiscale entropy in the FX market

    NASA Astrophysics Data System (ADS)

    Stosic, Darko; Stosic, Dusan; Ludermir, Teresa; Stosic, Tatijana

    2016-09-01

    The regularity of price fluctuations in exchange rates plays a crucial role in FX market dynamics. Distinct variations in regularity arise from economic, social and political events, such as interday trading and financial crisis. This paper applies a multiscale time-dependent entropy method on thirty-three exchange rates to analyze price fluctuations in the FX. Correlation matrices of entropy values, termed entropic correlations, are in turn used to describe global behavior of the market. Empirical results suggest a weakly correlated market with pronounced collective behavior at bi-weekly trends. Correlations arise from cycles of low and high regularity in long-term trends. Eigenvalues of the correlation matrix also indicate a dominant European market, followed by shifting American, Asian, African, and Pacific influences. As a result, we find that entropy is a powerful tool for extracting important information from the FX market.

  15. The Vision of Students Enrolled in European Technical Universities Regarding Tomorrow'S World

    NASA Astrophysics Data System (ADS)

    Duşe, Dan-Maniu; Nemeş, Cătălin

    2014-11-01

    Starting from Michael Rendell and his team's "Managing tomorrow's people", this paper sets out to build a possible future of leadership in European technical universities. We can ask ourselves if European technical universities could exist in a Blue, Green and Orange World. How would they look like and how efficient would "corporate" universities be, assuming that the Blue World would prevail in the next 10 years. What should their development strategies be and what labor markets would absorb its graduates? What if universities would be in the Green or Orange World? What leaders should they have then? Starting from these questions we try to construct possible scenarios for a European reality

  16. Patterns of contraceptive use in 5 European countries. European Study Group on Infertility and Subfecundity.

    PubMed Central

    Spinelli, A; Talamanca, I F; Lauria, L

    2000-01-01

    OBJECTIVES: The use of contraception in Denmark, Germany, Poland, Italy, and Spain is described. METHODS: Data were drawn from a population-based cross-sectional study, the European Study of Infertility and Subfecundity. Interviews were conducted with 6630 women aged 25 to 44 years. Logistic regression was used to estimate the effect of factors associated with contraceptive use. RESULTS: Residents of Northern European countries tended to use more effective methods of contraception than residents of Southern European countries. The use of contraception was generally more common among single women, the more highly educated, those with children, and those with a previous induced abortion. These characteristics were also the main determinants of the use of more effective methods. Periodic abstinence and withdrawal were more common among older women. CONCLUSIONS: The European countries are in different phases of contraceptive practice: in Northern and Western Europe, use of more modern methods has been stable over the past 10 years, whereas these methods are less common in Southern and Eastern Europe. The results suggest the need for information, education, and provision of contraceptive services in Eastern and Southern Europe. PMID:10983197

  17. European Schoolnet: Enabling School Networking

    ERIC Educational Resources Information Center

    Scimeca, Santi; Dumitru, Petru; Durando, Marc; Gilleran, Anne; Joyce, Alexa; Vuorikari, Riina

    2009-01-01

    School networking is increasingly important in a globalised world, where schools themselves can be actors on an international stage. This article builds on the activities and experience of the longest established European initiative in this area, European Schoolnet (EUN), a network of 31 Ministries of Education. First, we offer an introduction…

  18. The European Dimension in Education.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Directorate of Education, Culture and Sport, Documentation Section.

    This paper addresses concerns about a European dimension in education that has been created by the enlargement of the European Union (EU) (the inclusion of Austria, Finland, and Sweden) and the gradual transformations of institutions into a future federal state. Sections of the paper include: (1) "Introduction"; (2) "Defining the…

  19. Brazilian Portuguese Ethnonymy and Europeanisms.

    ERIC Educational Resources Information Center

    Stephens, Thomas M.

    1994-01-01

    Delineates the incorporation and analyzes the impact of European borrowings in Brazilian racio-ethnic terminology. This overview covers French, Italian, Spanish, and English influences. Borrowings from European languages have had a small impact on the calculus of Brazilian racio-ethnic terms. (43 references) (Author/CK)

  20. The President As Marketer

    ERIC Educational Resources Information Center

    Bickford, Robert I.

    1978-01-01

    Advocates a marketing orientation to community college management as demonstrated by the successful implementation of four-state (service, promotion, delivery, and evaluation) marketing plan at Prince George's Community College in Washington D.C. (TP)

  1. Marketing to maximize profitability.

    PubMed

    Duboff, R S

    1992-01-01

    An effective marketing strategy should focus on serving profitable customers, not just adding new ones. The author offers five steps that marketers can follow to ensure that their efforts provide the greatest boost to the bottom line.

  2. Marketing Your Program.

    ERIC Educational Resources Information Center

    Calderon, Jewell R.

    1978-01-01

    In this conference presentation, the author, contrary to traditional views, offers a marketing definition that is compatible with continuing education goals. She then points out five reasons why continuing education activities for nurses should be marketed. (EM)

  3. Why We Need Marketing.

    ERIC Educational Resources Information Center

    Harper, Nancy

    1984-01-01

    An interview with Philip Kotler, the Harold T. Martin Professor of Marketing at Northwestern University, is presented. Three approaches to marketing are identified: product-oriented, hard-sell, and building satisfaction in a long-term clientele. (MLW)

  4. Marketing Youth Services.

    ERIC Educational Resources Information Center

    Dimick, Barbara

    1995-01-01

    Marketing techniques in youth services are useful for designing programs, collections, and services and for determining customer needs. The marketing mix--product, place, price, and practice--provides a framework for service analysis. (AEF)

  5. Ending the war between Sales & Marketing.

    PubMed

    Kotler, Philip; Rackham, Neil; Krishnaswamy, Suj

    2006-01-01

    Sales departments tend to believe that marketers are out of touch with what's really going on in the marketplace. Marketing people, in turn, believe the sales force is myopic--too focused on individual customer experiences, insufficiently aware of the larger market, and blind to the future. In short, each group undervalues the other's contributions. Both stumble (and organizational performance suffers) when they are out of sync. Yet few firms seem to make serious overtures toward analyzing and enhancing the relationship between these two critical functions. Curious about the misalignment between Sales and Marketing, the authors interviewed pairs of chief marketing officers and sales vice presidents to capture their perspectives. They looked in depth at the relationship between Sales and Marketing in a variety of companies in different industries. Their goal was to identify best practices that could enhance the joint performance and increase the contributions of these two functions. Among their findings: The marketing function takes different forms in different companies at different product life cycle stages. Marketing's increasing influence in each phase of an organization's growth profoundly affects its relationship with Sales. The strains between Sales and Marketing fall into two main categories: economic (a single budget is typically divided, between Sales and Marketing, and not always evenly) and cultural (the two functions attract very different types of people who achieve success by spending their time in very different ways). In this article, the authors describe the four types of relationships Sales and Marketing typically exhibit. They provide a diagnostic to help readers assess their companies' level of integration, and they offer recommendations for more closely aligning the two functions.

  6. Ising model of financial markets with many assets

    NASA Astrophysics Data System (ADS)

    Eckrot, A.; Jurczyk, J.; Morgenstern, I.

    2016-11-01

    Many models of financial markets exist, but most of them simulate single asset markets. We study a multi asset Ising model of a financial market. Each agent has two possible actions (buy/sell) for every asset. The agents dynamically adjust their coupling coefficients according to past market returns and external news. This leads to fat tails and volatility clustering independent of the number of assets. We find that a separation of news into different channels leads to sector structures in the cross correlations, similar to those found in real markets.

  7. Vascular surgery: the European perspective.

    PubMed

    Harris, P

    1999-09-01

    Isaac Newton, among others, observed that 'we see so far because we are standing upon the shoulders of giants'. In vascular surgery most of the giants have been European, and this is a heritage which we as Europeans can take pride in and build upon if we chose to do so. As in other areas of life, commitment is essential in order to influence the future. For vascular surgeons in Europe this means active participation in the European scientific societies for vascular surgery and in the UEMS. The main value of the EBSQ.VASC assessments to date has been to expose the uneven standards of training in vascular surgery within the European Union. Only if action follows to address these inequalities will the tactics of the European Board of Vascular Surgery be vindicated.

  8. Multilingual Interaction in Plurilingual Classes ? European School Practice

    ERIC Educational Resources Information Center

    Muller, Alexandra; Beardsmore, Hugo Baetens

    2004-01-01

    The paper illustrates how interaction operates in classes where there is no single shared common language between teachers and pupils. Samples from a European School primary class taken from 1669 extracts are given of teacher-pupil, pupil-teacher and pupil-pupil interaction. Goals of the programme investigated are to integrate heterogeneous groups…

  9. The Bologna Process and the European Gain: Africa's Development Demise?

    ERIC Educational Resources Information Center

    Shawa, Lester Brian

    2008-01-01

    The Bologna process is a fundamental restructuring of higher education in Europe, of which the introduction of three cycles: bachelor's, master's and doctorate, in lieu of the traditional long program is the single most important feature. Its objectives are to increase the employability of European citizens and the competitiveness and…

  10. Dynamics of Markets

    NASA Astrophysics Data System (ADS)

    McCauley, Joseph L.

    2004-06-01

    Standard texts and research in economics and finance ignore the absence of evidence from the analysis of real, unmassaged market data to support the notion of Adam Smith's stabilizing Invisible Hand. In stark contrast, this text introduces a new empirically-based model of financial market dynamics that explains the volatility of prices options correctly and clarifies the instability of financial markets. The emphasis is on understanding how real markets behave, not how they hypothetically 'should' behave.

  11. Strategic Marketing for Presidents.

    ERIC Educational Resources Information Center

    Pappas, Richard J., Ed.

    Designed to inform the marketing efforts of community college presidents, this document describes the importance of marketing, presents a targeted approach, and outlines the specific roles and skills needed by the president to ensure successful efforts and effective institutions. The first chapter, "Developing a Marketing-Strategic…

  12. Marketing University Outreach Programs.

    ERIC Educational Resources Information Center

    Foster, Ralph S., Jr., Ed.; And Others

    A collection of 12 essays and model program descriptions addresses issues in the marketing of university extension, outreach, and distance education programs. They include: (1) "Marketing and University Outreach: Parallel Processes" (William I. Sauser, Jr. and others); (2) "Segmenting and Targeting the Organizational Market"…

  13. Marketing home care services.

    PubMed

    Moore, S T

    1987-08-01

    With the decline in inpatients, hospital administrators and marketers are seeking revenue opportunities in meeting the needs of a new market, home care patients. The challenge for managers in the home care arena is to target their marketing efforts towards the important decision makers. Managers who can best meet the goal of patients, families and professionals will be most successful.

  14. Entering the Corporate Market.

    ERIC Educational Resources Information Center

    Greenshields, Garry W.

    This seminar guide was designed for use with a series of slides in training administrators to market an educational program or service to corporations. The seminar explains the following eight stages in planning entry into the corporate market: identifying appropriate publics; researching the market (analyzing supply and demand, collecting data,…

  15. Marketing Across the Board.

    ERIC Educational Resources Information Center

    Lauer, Larry D.

    1999-01-01

    Outlines an eight-step approach to launching an integrated college or university marketing/fund-raising program: finding a visionary campus leader; getting presidential support; assembling a three-tier marketing structure; considering new ways of defining quality; developing a marketing "blueprint"; selling the program on campus; embracing…

  16. Rewards for Good Marketing

    ERIC Educational Resources Information Center

    Germain, Carol Anne, Ed.

    2009-01-01

    Many professional library associations and affiliates "strongly encourage" the marketing of libraries and their wares. These organizations present awards, certificates, and monetary enticements to honor outstanding marketing programs. For most individuals or teams who are already working on and implementing marketing programs, the added effort of…

  17. Managing Nonprofit Marketing.

    ERIC Educational Resources Information Center

    Johnson, Dennis L.

    1979-01-01

    Nonprofit marketing is an extension of the planning and management process, and a necessary new skill for the community college manager. Management must teach marketing concepts to faculty and all college personnel and communicate their role in the marketing process of the institution for a successful program. (RC)

  18. Marketing Farm Grain Crops.

    ERIC Educational Resources Information Center

    Ridenour, Harlan E.

    This vocational agriculture curriculum on grain marketing contains three parts: teacher guide, student manual, and student workbook. All three are coordinated and cross-referenced. The course is designed to give students of grain marketing a thorough background in the subject and provide practical help in developing grain marketing strategies for…

  19. Marketing for Camp Trends.

    ERIC Educational Resources Information Center

    Biddle, Alicia

    1998-01-01

    To effectively market a camp, current trends and issues must be considered: specialty programming, the Americans With Disabilities Act, competing recreational programs, changes in the school year, programming for seniors, and accountability. Camps should have a marketing strategy that includes public relations, a marketing plan, a pricing…

  20. Plugging into Marketing Education.

    ERIC Educational Resources Information Center

    Lunkenheimer, Gary; Swift, Teri

    This text contains activities that allow marketing education instructors to integrate their curriculum with word-processing, spreadsheet, and presentation software. Their students can gain experience with technology, fulfill marketing education learner outcomes, and meet the demands of a marketing job. The instructor provides an outline for…

  1. Marketing your programs.

    PubMed

    Bothner, Vera

    2002-01-01

    The programs and services that your organization develops can only achieve their desired goals if your clients are aware that they exist and know how to access them. Thus marketing your programs is essential. In this brief we explore the concept of social marketing and walk you through the steps to creating a marketing plan for your organization.

  2. Introduction to Agricultural Marketing.

    ERIC Educational Resources Information Center

    Futrell, Gene; And Others

    This marketing unit focuses on the importance of forecasting in order for a farm family to develop marketing plans. It describes sources of information and includes a glossary of marketing terms and exercises using both fundamental and technical methods to predict prices in order to improve forecasting ability. The unit is organized in the…

  3. Connecticut Marketing Education Handbook.

    ERIC Educational Resources Information Center

    West Haven Board of Education, CT.

    This revised marketing education handbook is intended to assist marketing education teachers and administrators in Connecticut in preparing students to enter meaningful careers in marketing, merchandising, and management positions. The 17 units of this reference guide cover the following topics: introduction; mission and scope of marketing…

  4. European Lean Gasoline Direct Injection Vehicle Benchmark

    SciTech Connect

    Chambon, Paul H; Huff, Shean P; Edwards, Kevin Dean; Norman, Kevin M; Prikhodko, Vitaly Y; Thomas, John F

    2011-01-01

    Lean Gasoline Direct Injection (LGDI) combustion is a promising technical path for achieving significant improvements in fuel efficiency while meeting future emissions requirements. Though Stoichiometric Gasoline Direct Injection (SGDI) technology is commercially available in a few vehicles on the American market, LGDI vehicles are not, but can be found in Europe. Oak Ridge National Laboratory (ORNL) obtained a European BMW 1-series fitted with a 2.0l LGDI engine. The vehicle was instrumented and commissioned on a chassis dynamometer. The engine and after-treatment performance and emissions were characterized over US drive cycles (Federal Test Procedure (FTP), the Highway Fuel Economy Test (HFET), and US06 Supplemental Federal Test Procedure (US06)) and steady state mappings. The vehicle micro hybrid features (engine stop-start and intelligent alternator) were benchmarked as well during the course of that study. The data was analyzed to quantify the benefits and drawbacks of the lean gasoline direct injection and micro hybrid technologies from a fuel economy and emissions perspectives with respect to the US market. Additionally that data will be formatted to develop, substantiate, and exercise vehicle simulations with conventional and advanced powertrains.

  5. Market segmentation strategy in internet market

    NASA Astrophysics Data System (ADS)

    Ren, Yawei; Yang, Deli; Diao, Xinjun

    2010-04-01

    This paper presents a model to describe the competitive dynamics of web sites on the WWW market and analyze the stability of the model which is composed of one powerful site and two small sites. One of the most important results that emerge from this simple model is that strong competition among websites does not necessarily lead to the demise of the small website on the WWW market. From the stability analysis of the model, we obtain a series of conditions in which small sites can obtain competitive advantages by using the market segmentation strategy.

  6. Marketing the hospital library.

    PubMed

    Bridges, Jane

    2005-01-01

    Many librarians do not see themselves as marketers, but marketing is an essential role for hospital librarians. Library work involves education, and there are parallels between marketing and education as described in this article. It is incumbent upon hospital librarians actively to pursue ways of reminding their customers about library services. This article reinforces the idea that marketing is an element in many of the things that librarians already do, and includes a list of suggested marketing strategies intended to remind administrators, physicians, and other customers that they have libraries in their organizations.

  7. Developing a market orientation.

    PubMed

    Hallums, A

    1994-03-01

    Developing a market-orientated organization is a complex task. An organization's market orientation is reflected in its ability to fulfil its customer's needs. The organization must look outside itself and adopt a flexible response to changing needs. This paper will examine what is meant by the term marketing and why it is necessary for an organization to incorporate the marketing concept. Analysis of the organization's culture and its relevance to the development of market orientation will also be considered. Reference will be made to health care where appropriate.

  8. [Healthcare marketing elements].

    PubMed

    Ameri, Cinzia; Fiorini, Fulvio

    2014-01-01

    Marketing puts its foundation on a few key concepts: need-demand, product-service, satisfaction, exchange, market, or business structure manufacturing / supply. The combination of these elements allows you to build an effective marketing strategy. Crucial in this respect is to remember the Porter matrix, which shows that for a correct analysis of the relevant market is necessary to refer to the "five forces at play", ie: customers, competitors, new entrants and substitutes threat. Another key lever for proper marketing oriented approach is the continuous and constant monitoring of the application, anticipating their dissatisfactions.

  9. 7 CFR 1212.14 - Market or marketing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Market or marketing. 1212.14 Section 1212.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING..., Promotion, Consumer Education, and Industry Information Order Definitions § 1212.14 Market or marketing....

  10. 7 CFR 1212.14 - Market or marketing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Market or marketing. 1212.14 Section 1212.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING..., Promotion, Consumer Education, and Industry Information Order Definitions § 1212.14 Market or marketing....

  11. 7 CFR 1212.14 - Market or marketing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Market or marketing. 1212.14 Section 1212.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING..., Promotion, Consumer Education, and Industry Information Order Definitions § 1212.14 Market or marketing....

  12. 7 CFR 1212.14 - Market or marketing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Market or marketing. 1212.14 Section 1212.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING..., Promotion, Consumer Education, and Industry Information Order Definitions § 1212.14 Market or marketing....

  13. 76 FR 3679 - Market Test of Marketing Mail Made Easy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... Market Test of Marketing Mail Made Easy AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY... involving the sale of Marketing Mail Made Easy. This document describes the proposed test, addresses... experimental market dominant product, Marketing Mail Made Easy (MMME).\\1\\ The market test will begin on...

  14. UK Higher Education Viewed through the Marketization and Marketing Lenses

    ERIC Educational Resources Information Center

    Nedbalová, Eva; Greenacre, Luke; Schulz, John

    2014-01-01

    This paper uses the Economic Market mechanisms and the 4P Marketing Mix as lenses to review the context of UK higher education (HE) and to explore the relationship between the market and marketing disciplines and practice. Four Economic Market mechanisms--autonomy, competition, price and information--are contrasted with the four Ps of marketing:…

  15. Market Research. Cooperative Education Marketing Digest Series 1.

    ERIC Educational Resources Information Center

    Pride, Cletis G.; Fowler, Joseph S.

    An overview of market research is provided, with advice about conducting market research for the educator. Market research is any kind of research that gives information about the current state of the market and offers guidance in improving one's position in that market. The relative advantages of conducting market research by oneself or by hiring…

  16. 7 CFR 1218.11 - Market or marketing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Market or marketing. 1218.11 Section 1218.11... Market or marketing. (a) Marketing means the sale or other disposition of blueberries in any channel of commerce. (b) To market means to sell or otherwise dispose of blueberries in interstate, foreign,...

  17. Managing hybrid marketing systems.

    PubMed

    Moriarty, R T; Moran, U

    1990-01-01

    As competition increases and costs become critical, companies that once went to market only one way are adding new channels and using new methods - creating hybrid marketing systems. These hybrid marketing systems hold the promise of greater coverage and reduced costs. But they are also hard to manage; they inevitably raise questions of conflict and control: conflict because marketing units compete for customers; control because new indirect channels are less subject to management authority. Hard as they are to manage, however, hybrid marketing systems promise to become the dominant design, replacing the "purebred" channel strategy in all kinds of businesses. The trick to managing the hybrid is to analyze tasks and channels within and across a marketing system. A map - the hybrid grid - can help managers make sense of their hybrid system. What the chart reveals is that channels are not the basic building blocks of a marketing system; marketing tasks are. The hybrid grid forces managers to consider various combinations of channels and tasks that will optimize both cost and coverage. Managing conflict is also an important element of a successful hybrid system. Managers should first acknowledge the inevitability of conflict. Then they should move to bound it by creating guidelines that spell out which customers to serve through which methods. Finally, a marketing and sales productivity (MSP) system, consisting of a central marketing database, can act as the central nervous system of a hybrid marketing system, helping managers create customized channels and service for specific customer segments.

  18. Operationalizing strategic marketing.

    PubMed

    Chambers, S B

    1989-05-01

    The strategic marketing process, like any administrative practice, is far simpler to conceptualize than operationalize within an organization. It is for this reason that this chapter focused on providing practical techniques and strategies for implementing the strategic marketing process. First and foremost, the marketing effort needs to be marketed to the various publics of the organization. This chapter advocated the need to organize the marketing analysis into organizational, competitive, and market phases, and it provided examples of possible designs of the phases. The importance and techniques for exhausting secondary data sources and conducting efficient primary data collection methods were explained and illustrated. Strategies for determining marketing opportunities and threats, as well as segmenting markets, were detailed. The chapter provided techniques for developing marketing strategies, including considering the five patterns of coverage available; determining competitor's position and the marketing mix; examining the stage of the product life cycle; and employing a consumer decision model. The importance of developing explicit objectives, goals, and detailed action plans was emphasized. Finally, helpful hints for operationalizing the communication variable and evaluating marketing programs were provided.

  19. Marketing Management Elements

    NASA Astrophysics Data System (ADS)

    Costoiu, M.; Ioana, A.; Semenescu, A.; Marcu, D.

    2016-11-01

    The article takes as a starting point several complementary definitions of marketing. Also present several key points related to marketing policy: defining the position that the company will occupy on the market with respect to competition, fixing the image with what will approach the market, achieving a balance between turnover rates profit and expenses as a condition for the survival of the company. In below article it is proposed an original concept of marketing management. This concept takes into consideration on the one hand correlations between company position in the market definition and on the other hand the image received by customers. The ultimate goal of this original concept of marketing management is to ensure an effective balance between: the turnover rate of profit and expenses of the company.

  20. A Good Beginning Makes a Good Market: The Effect of Different Market Opening Structures on Market Quality.

    PubMed

    Hinterleitner, Gernot; Leopold-Wildburger, Ulrike; Mestel, Roland; Palan, Stefan

    2015-01-01

    This paper deals with the market structure at the opening of the trading day and its influence on subsequent trading. We compare a single continuous double auction and two complement markets with different call auction designs as opening mechanisms in a unified experimental framework. The call auctions differ with respect to their levels of transparency. We find that a call auction not only improves market efficiency and liquidity at the beginning of the trading day when compared to the stand-alone continuous double auction, but also causes positive spillover effects on subsequent trading. Concerning the design of the opening call auction, we find no significant differences between the transparent and nontransparent specification with respect to opening prices and liquidity. In the course of subsequent continuous trading, however, market quality is slightly higher after a nontransparent call auction.

  1. A Good Beginning Makes a Good Market: The Effect of Different Market Opening Structures on Market Quality

    PubMed Central

    Hinterleitner, Gernot; Leopold-Wildburger, Ulrike; Mestel, Roland; Palan, Stefan

    2015-01-01

    This paper deals with the market structure at the opening of the trading day and its influence on subsequent trading. We compare a single continuous double auction and two complement markets with different call auction designs as opening mechanisms in a unified experimental framework. The call auctions differ with respect to their levels of transparency. We find that a call auction not only improves market efficiency and liquidity at the beginning of the trading day when compared to the stand-alone continuous double auction, but also causes positive spillover effects on subsequent trading. Concerning the design of the opening call auction, we find no significant differences between the transparent and nontransparent specification with respect to opening prices and liquidity. In the course of subsequent continuous trading, however, market quality is slightly higher after a nontransparent call auction. PMID:26351653

  2. [Community marketing of contraceptives].

    PubMed

    Urrutia, J M

    1987-09-01

    The 5-year-old community contraceptive distribution program developed by PROFAMILIA, Colombia's private family planning organization, has given excellent results, but several cost-effectiveness comparisons with social marketing programs have suggested that commercial distribution programs are superior. The community contraceptive distribution program has a high content of information and education activities, which produced significant increases in knowledge and use of contraception in the communities covered. It has been a fundamental support for the social marketing program, creating much of the demand for contraceptive products that the social marketing program has filled. The social marketing program has given good results in terms of volume of sales and in cost-effectiveness since 1976, prompting calls for replacement of the community contraceptive distribution program by the social marketing program in those sectors where knowledge and use of contraception have achieved acceptable levels. An experiment in the Department of Santander in 1984 and 1985 gave very favorable results, suggesting that community contraceptive distribution programs should be replaced by social marketing programs in all more developed markets. But economic problems in 1985 and the decision of manufacturers to decrease the profit margin for PROFAMILIA jeopardized the social marketing program. The community distribution program covered about 20% of the market. Reduced profits in the social marketing program threatened its continued expansion, at the same time that potential demand was growing because of increases in the fertile aged population and increased use of contraception. To meet the need, PROFAMILIA combined the community contraceptive distribution and social marketing programs into a new entity to be called community marketing. The strategy of the community marketing program will be to maintain PROFAMILIA's participation in the market and aid the growth of demand for

  3. North European Transect

    NASA Astrophysics Data System (ADS)

    Korja, Annakaisa; Heikkinen, Pekka J.; Roslov, Yuri; Ivanova, Nina; Verba, Marc; Sakoulina, Tamara

    2010-05-01

    A nearly continuous, 3600 km long, NE-running North European Transect (NET) is combined from the existing deep seismic reflection data sets in the Baltic Sea (BABEL, 1600 km), Northern Finland (FIRE 4-4A, 580 km) and Barents Sea (1-AR, 1440 km;). The reflective image of the deep crust is highly dependent on the thickness of the sedimentary cover. The cover is few hundred meters in the Baltic sea, few tens of meters in the land areas and few kilometers in the Barents Sea area. In the Barents Sea area, the seismic image is dominated by the layered structure of the sedimentary basins and the middle and lower crust are poorly imaged. Therefore the Moho boundary in the Barents Sea has been determined from wide-angle reflections. Geologically the transect covers the transition from Phanerozoic Europe to Precambrian Europe and back to the Phanerozoic Barents Sea Shelf. It displays how Northern Europe grew around Baltica in several tectonic episodes involving the formation and destruction of Columbia/Hudsonland, Rodinia and Pangea supercontinents. The paleo plateboundaries are traversed by subvertical transparent zones suggesting transpressional and trantensional environments. The BABEL lines image how the core of Baltica was formed by sequential accretion of microcontinents and arc terranes at the old continental margin during the Svecofennian Orogeny ~1.9-1.8 Ga .When Baltica joined the Columbia supercontinent, new terranes were added to its southern edge in the Sveocbaltic Orogeny (~1.8 Ga). During the dispersal of the Columbia, the Baltic Sea failed rift was formed, rapakivi granitoids were intruded and sedimentary basins were developed. An extended plate margin structure has been imposed on the Rodinian (Sveconorwegian) and Pangean additions (Variscan-Caledonian). Major crustal thinning takes place along a series of subvertical faults across the Trans-European Suture Zone marking the transition from Phanerozoic to Proterozoic Europe. The FIRE lines in Northen Finland

  4. Line managers as marketers.

    PubMed

    Rynne, T J

    1986-09-01

    Many hospital administrators and boards of directors, having overcome their initial opposition to advertising and hired a marketing professional, are wondering why their marketing programs have not accomplished all that they had hoped. The answer lies in their perception of who is responsible for marketing. Marketing is not a specialty separate from the disciplines of management--it is a basic management skill. Its goal is to satisfy the customer by providing products and services that meet the customer's needs, wants, and preferences. Line managers must understand the hospital's customers and make the critical day-to-day differences in satisfying them. They are the hospital's front-line marketers, and the marketing department's role is to support them in this function. The marketing department should develop the line managers' marketing skills by furnishing them with the appropriate tools: formats, models, examples, and instructions. In addition, the marketing staff should provide such specialized services as marketing research, ad agency management, and development of communications.

  5. DTCA of prescription medicines in the European Union: is there still a need for a ban?

    PubMed

    Poser, Mareen

    2010-12-01

    The pharmaceutical sector is one of the main markets in the European Union. The consumption of medicines is high and steadily increasing. However, the pharmaceutical market is subject to a wider range of restrictions than almost any other sector. The restrictions mainly apply to information provision and advertising practice within the community. One of the main features in pharmaceutical regulation is the ban on direct-to-consumer advertising (DTCA) of prescription medicines. However, an abolition of the ban is controversial in the European Community, especially as the pharmaceutical industry keeps pleading for its ability to use the highly effective marketing strategy of DTCA to promote prescription medicines to the general public. Such advertising is only allowed in two jurisdictions in the world, New Zealand and the United States. In both systems the impact of DTCA on the consumer and the economy has been subject to research. The outcome of these studies is outlined in this article. Since the European Commission has provided a new proposal to amend the current information practice regarding prescription medicines in 2008 (European Commission, Proposal for a Directive of the European Parliament and of the Council Amending, as Regards Information to the General Public on Medicinal Products Subject to Medical Prescription, Directive 2001/83/EC on the Community Code Relating to Medicinal Products for Human Use, COM/2008/0663 final) it is time to examine different options to regulate the provision of information and discuss the need for a ban of DTCA.

  6. The re-emergence of Eastern European science and technology

    SciTech Connect

    Weiss, C. Jr.

    1993-01-01

    Economic competitiveness, and with it the survival of democracy in Eastern Europe, depends in large part on the ability of the region to manage technology for manufacturing exports. Most East European products are now oriented toward civilian and military needs of the former Soviet Union, and cannot now be sold anywhere. The communist system of central planning and soft budgets provided no incentive to manage technology or any other resource. Innovation was hampered by isolation from changes in world markets and technology, and by the separation of teaching, research, and production. Teaching was carried out on schools and universities, research in government institutes, and production in state-owned enterprises. Eastern European scientific and technological infrastructure is oversized, under-equipped, and politicized, but includes a strong nucleus which could be reformed and reoriented towards world markets. This process is beginning in several countries. But public support is lacking, as are funds for long-range investments. Strategic alliances are urgently needed with western firms and researchers with an understanding of world markets. 15 refs., 3 tabs.

  7. The Rewards of Human Capital Competences for Young European Higher Education Graduates

    ERIC Educational Resources Information Center

    Garcia-Aracil, Adela; Mora, Jose-Gines; Vila, Luis E.

    2004-01-01

    The labour market rewards for a number of required human capital competences are analysed using a sample of young European higher education graduates. Factor analysis is applied to classify competences by jobs into eight orthogonal groups, namely participative, methodological, specialised, organisational, applying rules, physical, generic and…

  8. Beyond ESOL? Assessing the Propensity of East European Migrant Workers to Undertake Further and Higher Education

    ERIC Educational Resources Information Center

    French, Steve

    2012-01-01

    This article analyses the labour market participation of east Europeans living and working in East Staffordshire and Derby. It is based upon research which examines the qualifications and occupations of these migrant workers and which also seeks to ascertain their future intentions in respect of settlement, and the propensity to undertake…

  9. The Bologna Process and Higher Education in Mercosur: Regionalization or Europeanization?

    ERIC Educational Resources Information Center

    de Azevedo, Mário Luiz Neves

    2014-01-01

    Over the past two decades regional agreements have become more significant in educational and training. This paper situates and analyses the European Higher Education Area (EHEA), the Bologna Process and the Lisbon Strategy and explores their influence on the integration of higher education systems in Mercosur (the Southern Common Market of…

  10. School Choice Research in Five European Countries: The Circulation of Stephen Ball's Concepts and Interpretations

    ERIC Educational Resources Information Center

    van Zanten, Agnès; Kosunen, Sonja

    2013-01-01

    This article analyzes the influence of Stephen Ball's work on research on markets and school choice in five European countries (Finland, France, Norway, Spain, and Sweden). The main focus is on the intellectual circulation of ideas, but the authors also take into account the relationship between ideas and social and political changes, as well as…

  11. Social Impact of the "Digital Divide" in a Central-Eastern European Country.

    ERIC Educational Resources Information Center

    Dragulanescu, Nicolae-George

    2002-01-01

    Discusses the social impact of the digital divide in Central-Eastern European countries as well as between them and industrialized developed countries, based on experiences in Romania. Highlights include facts relating to digital divide worldwide; transition to a democratic and market-based economy and from socialism to capitalism; barriers to…

  12. Analysis of French generic medicines retail market: why the use of generic medicines is limited.

    PubMed

    Dylst, Pieter; Vulto, Arnold; Simoens, Steven

    2014-12-01

    The market share of generic medicines in France is low compared to other European countries. This perspective paper provides an overview of the generic medicines retail market in France and how the current policy environment may affect the long-term sustainability. Looking at the French generic medicines retail market and the surrounding regulatory framework, all conditions seem to be in place to create a healthy generic medicines market: the country has well-respected regulatory authorities, generic medicines enter the market in a timely manner and prices of generic medicines are competitive compared with other European countries. Despite the success of the demand-side policies targeted at pharmacists and patients, those targeted at physicians were less successful due to a lack of enforcement and a lack of trust in generic medicines by French physicians. Recommendations to increase the use of generic medicines in France round off this perspective paper.

  13. Statistical analysis of fixed income market

    NASA Astrophysics Data System (ADS)

    Bernaschi, Massimo; Grilli, Luca; Vergni, Davide

    2002-05-01

    We present cross and time series analysis of price fluctuations in the US Treasury fixed income market. Bonds have been classified according to a suitable metric based on the correlation among them. The classification shows how the correlation among fixed income securities depends strongly on their maturity. We study also the structure of price fluctuations for single time series.

  14. Photopatch testing: recommendations for a European photopatch test baseline series.

    PubMed

    Gonçalo, Margarida; Ferguson, James; Bonevalle, Annie; Bruynzeel, Derk P; Giménez-Arnau, Ana; Goossens, An; Kerr, Alastair; Lecha, Mario; Neumann, Norbert; Niklasson, Bo; Pigatto, Paolo; Rhodes, Lesley E; Rustemeyer, Thomas; Sarkany, Robert; Thomas, Pierre; Wilkinson, Mark

    2013-04-01

    In order to establish a consensus recommendation for performing photopatch testing, a photopatch test taskforce group was established under the joint umbrella of the European Society for Contact Dermatitis and the European Society for Photodermatology in 2000. After proposing the most adequate methodology in 2004 and completing a European multicentre photopatch test study in 2011, this taskforce is recommending a list of photoallergens that should form part of a baseline series for photopatch testing in Europe. It contains mainly ultraviolet filters and drugs, mostly non-steroidal anti-inflammatory drugs. The choice of chemicals was based on the results of a recent multicentre study, previous published cases of photoallergy, and use of the substances in the European market. It is suggested that an extended list of photoallergens should be photopatch tested in selected cases, along with patients' own products. Two contact allergens, cinnamyl alcohol and decyl glucoside, should be simultaneously patch tested in order to clarify photopatch and patch test reactions, respectively, to ketoprofen and methylene bis-benzotriazolyl tetramethylbutylphenol (Tinosorb M™).

  15. The European community and its standardization efforts in medical informatics

    NASA Astrophysics Data System (ADS)

    Mattheus, Rudy A.

    1992-07-01

    A summary of the CEN TC 251/4 ''Medical Imaging and Multi-Media'' activities will be given. CEN is the European standardization institute, TC 251 deals with medical informatics. Standardization is a condition for the wide scale use of health care and medical informatics and for the creation of a common market. In the last two years, three important categories-- namely, the Commission of the European Communities with their programs and the mandates, the medical informaticians through their European professional federation, and the national normalization institutes through the European committee--have shown to be aware of this problem and have taken actions. As a result, a number of AIM (Advanced Informatics in Medicine), CEC sponsored projects, the CEC mandates to CEN and EWOS, the EFMI working group on standardization, the technical committee of CEN, and the working groups and project teams of CEN and EWOS are working on the subject. On overview of the CEN TC 251/4 ''Medical Imaging and Multi-Media'' activities will be given, including their relation to other work.

  16. Evolution of microbial markets.

    PubMed

    Werner, Gijsbert D A; Strassmann, Joan E; Ivens, Aniek B F; Engelmoer, Daniel J P; Verbruggen, Erik; Queller, David C; Noë, Ronald; Johnson, Nancy Collins; Hammerstein, Peter; Kiers, E Toby

    2014-01-28

    Biological market theory has been used successfully to explain cooperative behavior in many animal species. Microbes also engage in cooperative behaviors, both with hosts and other microbes, that can be described in economic terms. However, a market approach is not traditionally used to analyze these interactions. Here, we extend the biological market framework to ask whether this theory is of use to evolutionary biologists studying microbes. We consider six economic strategies used by microbes to optimize their success in markets. We argue that an economic market framework is a useful tool to generate specific and interesting predictions about microbial interactions, including the evolution of partner discrimination, hoarding strategies, specialized versus diversified mutualistic services, and the role of spatial structures, such as flocks and consortia. There is untapped potential for studying the evolutionary dynamics of microbial systems. Market theory can help structure this potential by characterizing strategic investment of microbes across a diversity of conditions.

  17. Evolution of microbial markets

    PubMed Central

    Werner, Gijsbert D. A.; Strassmann, Joan E.; Ivens, Aniek B. F.; Engelmoer, Daniel J. P.; Verbruggen, Erik; Queller, David C.; Noë, Ronald; Johnson, Nancy Collins; Hammerstein, Peter; Kiers, E. Toby

    2014-01-01

    Biological market theory has been used successfully to explain cooperative behavior in many animal species. Microbes also engage in cooperative behaviors, both with hosts and other microbes, that can be described in economic terms. However, a market approach is not traditionally used to analyze these interactions. Here, we extend the biological market framework to ask whether this theory is of use to evolutionary biologists studying microbes. We consider six economic strategies used by microbes to optimize their success in markets. We argue that an economic market framework is a useful tool to generate specific and interesting predictions about microbial interactions, including the evolution of partner discrimination, hoarding strategies, specialized versus diversified mutualistic services, and the role of spatial structures, such as flocks and consortia. There is untapped potential for studying the evolutionary dynamics of microbial systems. Market theory can help structure this potential by characterizing strategic investment of microbes across a diversity of conditions. PMID:24474743

  18. [The use of nanotechnology in medicinal products in the light of European Union law].

    PubMed

    Jurewicz, Margin

    2014-12-01

    The purpose of EU regulations in relation to nanotechnology, according to the European Commission's Communication "Regulatory aspects of nanomaterials", is to allow the public to use innovative applications of nanotechnology while ensuring a high level of safety, health care and environmental protection. This article characterizes and comments on EU legislation in respect of medicinal products containing nanomaterials. Medicinal products manufactured using nanotechnology are subject to the optional centralized authorization procedure by the European Commission authorizations for the placing on the market throughout the EU; advanced therapy medicinal products containing nanomaterials are covered by the mandatory centralized procedure. Evaluation of medicines in centralized authorization mode for the marketing of medicinal products, including those containing nanomaterials, is carried out by the Committee on Medicinal Products for Human Use (CHMP) subject to the European Medicines Agency (EMA).

  19. 2013 Bioenergy Market Report

    SciTech Connect

    Schwab, Amy; Moriarty, Kristi; Milbrandt, Anelia; Geiger, Jesse; Lewis, John

    2016-03-28

    This report provides a status of the markets and technology development involved in growing a domestic bioenergy economy as it existed at the end of 2013. It compiles and integrates information to provide a snapshot of the current state and historical trends influencing the development of bioenergy markets. This information is intended for policy-makers as well as technology developers and investors tracking bioenergy developments. It also highlights some of the key energy and regulatory drivers of bioenergy markets.

  20. Targeting biodefense markets.

    PubMed

    Olinger, Gene Garrard

    2009-10-01

    The "World Vaccine Congress 2009" held in Washington D.C. (April 20-23, 2009) sponsored several sessions focused on the vaccine market targeting biodefense. On day one of the congress, a panel discussion outlined the federal progress in medical countermeasure preparedness that included emerging infections, influenza, and biodefense focuses. The second day, a session focused on the biodefense vaccine market with both government and industry members discussing the opportunities and challenges associated with the budding market.

  1. Communication impacting financial markets

    NASA Astrophysics Data System (ADS)

    Vitting Andersen, Jørgen; Vrontos, Ioannis; Dellaportas, Petros; Galam, Serge

    2014-10-01

    Since the attribution of the Nobel prize in 2002 to Kahneman for prospect theory, behavioral finance has become an increasingly important subfield of finance. However the main parts of behavioral finance, prospect theory included, understand financial markets through individual investment behavior. Behavioral finance thereby ignores any interaction between participants. We introduce a socio-financial model (Vitting Andersen J. and Nowak A., An Introduction to Socio-Finance (Springer, Berlin) 2013) that studies the impact of communication on the pricing in financial markets. Considering the simplest possible case where each market participant has either a positive (bullish) or negative (bearish) sentiment with respect to the market, we model the evolution of the sentiment in the population due to communication in subgroups of different sizes. Nonlinear feedback effects between the market performance and changes in sentiments are taken into account by assuming that the market performance is dependent on changes in sentiments (e.g., a large sudden positive change in bullishness would lead to more buying). The market performance in turn has an impact on the sentiment through the transition probabilities to change an opinion in a group of a given size. The idea is that if for example the market has observed a recent downturn, it will be easier for even a bearish minority to convince a bullish majority to change opinion compared to the case where the meeting takes place in a bullish upturn of the market. Within the framework of our proposed model, financial markets stylized facts such as volatility clustering and extreme events may be perceived as arising due to abrupt sentiment changes via ongoing communication of the market participants. The model introduces a new volatility measure which is apt of capturing volatility clustering and from maximum-likelihood analysis we are able to apply the model to real data and give additional long term insight into where a market is

  2. Derived enriched uranium market

    SciTech Connect

    Rutkowski, E.

    1996-12-01

    The potential impact on the uranium market of highly enriched uranium from nuclear weapons dismantling in the Russian Federation and the USA is analyzed. Uranium supply, conversion, and enrichment factors are outlined for each country; inventories are also listed. The enrichment component and conversion components are expected to cause little disruption to uranium markets. The uranium component of Russian derived enriched uranium hexafluoride is unresolved; US legislation places constraints on its introduction into the US market.

  3. Market place movements

    SciTech Connect

    1996-10-01

    Historical financial data is provided for the uranium market in graphical and tabular form. Data include uranium spot price range, spot conversion price range, and seperative work units price range. Additional spot market information provided is natural uranium by buyers and sellers. Medium- and long-term data includes average natural uranium prices, and natural uranium market by buyers and sellers. Information on US contracted supply and demand and uranium production in Australia, Canada, and the US is given.

  4. [Safe usage of chemicals in European Union countries].

    PubMed

    Graczyk, Anna; Czerczak, Sławomir; Barański, Bogusław

    2010-01-01

    New legal provisions have changed the rules of production, import and use of chemicals in the European Union Member States. Chemical substances present on the common market are covered by registration duty. Manufacturers and importers of substances are obliged to ensure that the risk posed by a given substance is adequately controlled on each stage. Information on substances is to be transferred both downstream and upstream in a supply chain. Substances of very high concern are the subject of authorisation procedure and will be gradually replaced by their safer equivalents. Information on substances of very high concern is transferred to downstream users and consumers. The European Chemicals Agency (ECHA) and Member States Competent Authorities have been established. National Helpdesks on REACH are operating in Member States, giving help to enterprises and other stakeholders.

  5. Tracks for Eastern/Western European Future Launch Vehicles Cooperation

    NASA Astrophysics Data System (ADS)

    Eymar, Patrick; Bertschi, Markus

    2002-01-01

    exclusively upon Western European elements indigenously produced. Yet some private initiatives took place successfully in the second half of the nineties (Eurockot and Starsem) bringing together companies from Western and Eastern Europe. Evolution of these JV's are already envisioned. But these ventures relied mostly on already existing vehicles. broadening the bases in order to enlarge the reachable world market appears attractive, even if structural difficulties are complicating the process. had recently started to analyze, with KSRC counterparts how mixing Russian and Western European based elements would provide potential competitive edges. and RKA in the frame of the new ESA's Future Launch Preparatory Programme (FLPP). main technical which have been considered as the most promising (reusable LOx/Hydrocarbon engine, experimental reentry vehicles or demonstrators and reusable launch vehicle first stage or booster. international approach. 1 patrick.eymar@lanceurs.aeromatra.com 2

  6. Reimbursement for Continuous Glucose Monitoring: A European View

    PubMed Central

    Heinemann, Lutz; Franc, Sylvia; Phillip, Moshe; Battelino, Tadej; Ampudia-Blasco, Francisco Javier; Bolinder, Jan; Diem, Peter; Pickup, John; Hans DeVries, J.

    2012-01-01

    Different systems for continuous glucose monitoring (CGM) are available on the European market. There is no unlimited reimbursement for CGM use in any European country, but in some countries, reimbursement exists for certain clinical indications. The aim of this commentary is to describe the different reimbursement situations across Europe for this innovative but costly technology, as a prelude to establishing more uniform use. From the perspective of many scientists and clinicians, a number of randomized controlled trials have demonstrated the efficacy of real-time CGM versus self-monitoring of blood glucose, at least for hemoglobin A1c reduction. Nevertheless, according to many health care professionals and potential CGM users, national health services and health insurance organizations are reluctant to reimburse CGM. Imminent technological and manufacturing developments are expected to reduce the day-to-day costs of CGM. PMID:23294797

  7. Comparing illicit drug use in 19 European cities through sewage analysis.

    PubMed

    Thomas, Kevin V; Bijlsma, Lubertus; Castiglioni, Sara; Covaci, Adrian; Emke, Erik; Grabic, Roman; Hernández, Félix; Karolak, Sara; Kasprzyk-Hordern, Barbara; Lindberg, Richard H; Lopez de Alda, Miren; Meierjohann, Axel; Ort, Christoph; Pico, Yolanda; Quintana, José B; Reid, Malcolm; Rieckermann, Jörg; Terzic, Senka; van Nuijs, Alexander L N; de Voogt, Pim

    2012-08-15

    The analysis of sewage for urinary biomarkers of illicit drugs is a promising and complementary approach for estimating the use of these substances in the general population. For the first time, this approach was simultaneously applied in 19 European cities, making it possible to directly compare illicit drug loads in Europe over a 1-week period. An inter-laboratory comparison study was performed to evaluate the analytical performance of the participating laboratories. Raw 24-hour composite sewage samples were collected from 19 European cities during a single week in March 2011 and analyzed for the urinary biomarkers of cocaine, amphetamine, ecstasy, methamphetamine and cannabis using in-house optimized and validated analytical methods. The load of each substance used in each city was back-calculated from the measured concentrations. The data show distinct temporal and spatial patterns in drug use across Europe. Cocaine use was higher in Western and Central Europe and lower in Northern and Eastern Europe. The extrapolated total daily use of cocaine in Europe during the study period was equivalent to 356 kg/day. High per capita ecstasy loads were observed in Dutch cities, as well as in Antwerp and London. In general, cocaine and ecstasy loads were significantly elevated during the weekend compared to weekdays. Per-capita loads of methamphetamine were highest in Helsinki and Turku, Oslo and Budweis, while the per capita loads of cannabis were similar throughout Europe. This study shows that a standardized analysis for illicit drug urinary biomarkers in sewage can be applied to estimate and compare the use of these substances at local and international scales. This approach has the potential to deliver important information on drug markets (supply indicator).

  8. Market review: Market values summary July market review/current market data

    SciTech Connect

    1996-08-01

    A summary of financial data for the uranium spot market is provided. Recent transactions are tabulated, including uranium sales, natural uranium loans, conversion sales, and enrichment sales. A market values summary and long-term price indicators are also provided. The July 1996 market review data includes summaries of near-term uranium sales, near-term supply/demand, NUEXCO values, USEC prices, and calculated worth of enriched uranium. Active projects in uranium, conversion, and separative work supply and demand are listed. International market values are tabulated for 22 selected currencies.

  9. Market Review: Market values summary/April market review/current market data

    SciTech Connect

    1996-05-01

    This article is the April 1996 Uranium transactions summary. Data is presented on the supply, demand, and prices of U3O8, conversion services, and separative work units. During this period, market activity slowed, with only four transactions in the spot market. Prices strengthened slightly. There were five deals in the long-term U3O8 market and one deal in the conversion market. Active demand increased to 1.1 million pounds U3O8, while active supply increased to 4.8 million pounds U3O8.

  10. Marketing veterinary services.

    PubMed

    Lee, David E

    2006-03-01

    Marketing is a holistic process that goes far beyond a Yellow Page advertisement or a glossy brochure. A thorough evaluation of a market before entry, including best and worst case scenarios, is critical to mak-ing good investments. Veterinarians are fortunate to have a market that is largely protected by barriers to entry and characterized by reasonably high rates of return given minimal risk. Our market base continues to expand and, overall, remains fairly price insensitive. The extent to which a practice can align its capabilities with a product mix that ideally meets its clients' needs will ultimately determine its success.

  11. Internet marketing 401.

    PubMed

    Miller, Ryan J

    2010-11-01

    For facial plastic surgeons who are already realizing increased patient consultation requests from their online marketing efforts, the primary concern often becomes implementing additional tactics and strategies that can keep their online marketing fresh, relevant, and effective. This article creates a framework for evaluating advanced online marketing opportunities by analyzing each opportunity according to the variables of possible return, average cost to implement, probability of success, and implementation time. Within this framework, 11 distinct tactics are discussed, with special emphasis on the most common marketing needs and challenges of facial plastic surgery practices.

  12. Marketing a Radiology Practice.

    PubMed

    Levin, David C; Rao, Vijay M; Flanders, Adam E; Sundaram, Baskaran; Colarossi, Margaret

    2016-10-01

    In addition to being a profession, the practice of radiology is a business, and marketing is an important part of that business. There are many facets to marketing a radiology practice. The authors present a number of ideas on how to go about doing this. Some marketing methods can be directed to both patients and referring physicians. Others should be directed just to patients, while still others should be directed just to referring physicians. Aside from marketing, many of them provide value to both target audiences.

  13. Considerations for Emerging Markets for Energy Savings Certificates

    SciTech Connect

    Friedman, Barry; Bird, Lori; Barbose, Galen

    2008-10-01

    Early experiences with energy savings certificates (ESCs) have revealed both their merit and the challenges associated with them. In the United States, there has been little activity to date, so any lessons must be drawn from experiences in Italy, the United Kingdom (UK), France, and elsewhere. The staying power of European examples, particularly in Italy, demonstrates that ESCs can help initiate more efficiency projects. Although a robust market for renewable energy certificates (RECs) has emerged in both the voluntary and policy compliance contexts in the United States, ESCs have yet to gain significant traction. This report looks at the opportunity presented by ESCs, the unique challenges they bring, a comparison with RECs that can inform expectations about ESC market development, and the solutions and best practices early ESC market experience have demonstrated. It also examines whether there are real market barriers that have kept ESCs from being adopted and what structural features are necessary to develop effective trading programs.

  14. Shareholding relationships in the Euro Area banking market: A network perspective

    NASA Astrophysics Data System (ADS)

    Pecora, Nicolò; Spelta, Alessandro

    2015-09-01

    In this paper we analyze the topological properties of the network of the Euro Area banking market network, with the primary aim of assessing the importance of a bank in the financial system with respect to ownership and control of other credit institutions. The network displays power law distributions in both binary and weighted degree metrics indicating a robust yet fragile structure and a direct link between an increase of control diversification and a rise in the market power. Therefore while in good time the network is seemingly robust, in bad times many banks can simultaneously go into distress. This behavior paves the way for Central bank's actions. In particular we investigate whether the Single Supervisory Mechanism introduced by the European Central Banks and based on banks' total asset is a good proxy to quantify their systemic importance. Results indicate that not all the financial institutions with high valued total assets are systemically important but only few of them. Moreover the network structure reveals that control is highly concentrated, with few important shareholders approximately controlling a separate subset of banks.

  15. The European Union's emissions trading system in perspective

    SciTech Connect

    A. Denny Ellerman; Paul L. Joskow

    2008-05-15

    The performance of the European Union's Emissions Trading System (EU ETS) to date cannot be evaluated without recognizing that the first three years from 2005 through 2007 constituted a 'trial' period and understanding what this trial period was supposed to accomplish. Its primary goal was to develop the infrastructure and to provide the experience that would enable the successful use of a cap-and-trade system to limit European GHG emissions during a second trading period, 2008-12, corresponding to the first commitment period of the Kyoto Protocol. The trial period was a rehearsal for the later more serious engagement and it was never intended to achieve significant reductions in CO{sub 2} emissions in only three years. In light of the speed with which the program was developed, the many sovereign countries involved, the need to develop the necessary data, information dissemination, compliance and market institutions, and the lack of extensive experience with emissions trading in Europe, we think that the system has performed surprisingly well. Although there have been plenty of rough edges, a transparent and widely accepted price for tradable CO{sub 2} emission allowances emerged by January 1, 2005, a functioning market for allowances has developed quickly and effortlessly without any prodding by the Commission or member state governments, the cap-and-trade infrastructure of market institutions, registries, monitoring, reporting and verification is in place, and a significant segment of European industry is incorporating the price of CO{sub 2} emissions into their daily production decisions. The development of the EU ETS and the experience with the trial period provides a number of useful lessons for the U.S. and other countries. 27 refs., 7 figs., 5 tabs.

  16. 7 CFR 1206.12 - Market or marketing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Market or marketing. 1206.12 Section 1206.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.12 Market or...

  17. 7 CFR 1206.12 - Market or marketing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Market or marketing. 1206.12 Section 1206.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.12 Market or...

  18. 7 CFR 1206.12 - Market or marketing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Market or marketing. 1206.12 Section 1206.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.12 Market or...

  19. 7 CFR 1206.12 - Market or marketing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Market or marketing. 1206.12 Section 1206.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.12 Market or...

  20. The Marketing Plan: An Integrative Device for Teaching Marketing Management.

    ERIC Educational Resources Information Center

    Berdine, W. R.; Petersen, James C.

    1980-01-01

    The importance of the marketing plan is stressed as an integrative device for teaching marketing management, and a structure is presented to assist students in designing a marketing plan. Components of this plan include marketing objectives, targeting market and buying motives, external environment and competition, product, price, and promotion.…

  1. Labor Market Information for Business and Marketing Occupations. Draft.

    ERIC Educational Resources Information Center

    Wisconsin Univ., Madison. Dept. of Economics.

    This paper reviews and analyzes labor market trends to provide information for business and marketing program planners. Emphasizing the demand side of the market, the paper considers only those aspects of labor markets that have an impact on the supply of students to business and marketing programs and the demand for graduates of those programs.…

  2. Marketing orientation: how do hospital administrators compare with marketing managers?

    PubMed

    Bartlett, P J; Schewe, C D; Allen, C T

    1984-01-01

    A recent study shows that the marketing orientation of hospital administrators is similar to that of marketing practitioners but that hospital administrators have an underdeveloped sense of market segmentation and market aggressiveness regarding their patients and physicians. Studies such as this one can be helpful in applying marketing techniques to today's hospitals.

  3. High resolution earth observation satellites and services in the next decade a European perspective

    NASA Astrophysics Data System (ADS)

    Schreier, Gunter; Dech, Stefan

    2005-07-01

    Projects to use very high resolution optical satellite sensor data started in the late 90s and are believed to be the major driver for the commercialisation of earth observation. The global political security situation and updated legislative frameworks created new opportunities for high resolution, dual use satellite systems. In addition to new optical sensors, very high resolution synthetic aperture radars will become in the next few years an important component in the imaging satellite fleet. The paper will review the development in this domain so far, and give perspectives on future emerging markets and opportunities. With dual-use satellite initiatives and new political frameworks agreed between the European Commission and the European Space Agency (ESA), the European market becomes very attractive for both service suppliers and customers. The political focus on "Global Monitoring for Environment and Security" (GMES) and the "European Defence and Security Policy" drive and amplify this demand which ranges from low resolution climate monitoring to very high resolution reconnaissance tasks. In order to create an operational and sustainable GMES in Europe by 2007, the European infrastructure need to be adapted and extended. This includes the ESA SENTINEL and OXYGEN programmes, aiming for a fleet of earth observation satellites and an open and operational earth observation ground segment. The harmonisation of national and regional geographic information is driven by the European Commission's INSPIRE programme. The necessary satellite capacity to complement existing systems in the delivery of space based data required for GMES is currently under definition. Embedded in a market with global competition and in the global political framework of a Global Earth Observation System of Systems, European companies, agencies and research institutions are now contributing to this joint undertaking. The paper addresses the chances, risks and options for the future.

  4. Use of the conditional marketing authorization pathway for oncology medicines in Europe.

    PubMed

    Hoekman, J; Boon, W P C; Bouvy, J C; Ebbers, H C; de Jong, J P; De Bruin, M L

    2015-11-01

    Conditional marketing authorization (CMA) in the European Union (EU) is an early access pathway for medicines that show promising therapeutic effects, but for which comprehensive data are not available. Using a mixed quantitative-qualitative research design, we evaluated how CMA has been used in marketing authorization of oncology medicines in the period 2006 to 2013. We show that compared to full marketing authorization, CMA is granted based on less comprehensive data. However, this is accompanied by significantly longer assessment times and less consensus among regulators about marketing authorization. Moreover, development time from first-in-human testing to marketing authorization did not differ between full marketing authorization and CMA, but was significantly longer for CMA compared to accelerated approved products in the United States (US). Results indicate that CMA is not used by companies as a prospectively planned pathway to obtain early access, but as a "rescue option" when submitted data are not strong enough to justify full marketing authorization.

  5. Successful comeback of the single-dose live oral cholera vaccine CVD 103-HgR.

    PubMed

    Herzog, Christian

    2016-01-01

    Effective and easy to administer cholera vaccines are in need more than ever, for at risk populations and travellers alike. In many parts of the world cholera is still endemic, causing outbreaks and constituting repeatedly serious public health problems. The oral live cholera vaccine CVD 103-HgR (Orochol, Mutachol), the first genetically modified organism (GMO) used as vaccine, was in its time (launched 1993, Switzerland) the ideal cholera vaccine: single-dose, protective efficacy of 80-100% against moderate to severe cholera, acting within 8 days and exhibiting excellent safety, indiscernible from placebo. However, there were strong headwinds: In the 1990s the indication for cholera vaccines was generally downplayed by experts and in 1997 the European Commission called for a moratorium of GMOs which blocked the registration in the European Union. Thus, demand for this vaccine remained low and in 2003 it was taken off the market for economic reasons. After a decade in obscurity it (Vaxchora) has resurfaced again, now produced in the U.S. and equipped with a U.S. FDA license (June 10, 2016). What had happened? This commentary gives a critical account of an almost unbelievable string of misadventures, emerging adverse circumstances and man-made failures which nearly killed this single-dose live oral cholera vaccine. The good news is that patience and persistence lead to success in the end, allowing good science to prevail for the benefit of those in need.

  6. The Growth of Halal Meat Markets in Europe: An Exploration of the Supply Side Theory of Religion

    ERIC Educational Resources Information Center

    Lever, John; Miele, Mara

    2012-01-01

    Over the last 15 years dedicated markets for halal meat have emerged in a number of European countries. While ethnic stores still constitute the major retail outlet for halal meat in most countries, "halal" labelled meat and meat products are increasingly available in supermarkets and fast food restaurants. Market expansion has also…

  7. Systems of Organization and Allocation of National Resources for Scientific Research: Some International Comparisons and Conclusions for New Market Economies.

    ERIC Educational Resources Information Center

    Weiss, Charles, Jr.; Passman, Sidney

    1991-01-01

    Reviews science and technology policymaking in five countries with free-market economies: the United Kingdom, Germany, France, the Republic of Korea, and the United States. Implications for eastern European and other countries currently reorganizing toward domestic market economies and greater orientation toward world trade are discussed. (61…

  8. Emissions markets, power markets and market power: A study of the interactions between contemporary emissions markets and deregulated electricity markets

    NASA Astrophysics Data System (ADS)

    Dormady, Noah Christopher

    Chapter 1: A Monte Carlo Approach. The use of auctions to distribute tradeable property rights to firms in already heavily concentrated markets may further exacerbate the problems of market power that exist within those markets. This chapter provides a model of a two-stage emissions market modeled after a contemporary regional permit trading market in the United States, the Regional Greenhouse Gas Initiative, Inc. (RGGI). It then introduces Oligopsony 1.0, a C# software package constructed in the .NET environment that simulates uniform-price auctions using stochastic Monte Carlo simulation for modeling market power in tradeable property rights auctions. Monte Carlo methods add a probabilistic element to standard auction theoretic equilibria. The results of these simulations indicate that there can be significant non-linearities between profit and market power as exercised through strategic demand reduction. This analysis finds the optimum point of strategic demand reduction that enables the firm to exploit these non-linearities, and it determines the probability distributions of these optima using kernel density analysis. Chapter 2: An Experimental Approach. How will emerging auction-based emissions markets function within the context of today's deregulated auction-based electricity markets? This chapter provides an experimental analysis of a joint energy-emissions market. The impact of market power and collusion among dominant firms is evaluated to determine the extent to which an auction-based tradeable permit market influences performance in an adjacent electricity market. The experimental treatment design controls for a variety of real-world institutional features, including variable demand, permit banking, inter-temporal (multi-round) dynamics, a tightening cap, and resale. Results suggest that the exercise of market power significantly increases electricity auction clearing prices, without significantly increasing emissions

  9. Education, employment, and sustainable development in the European union

    NASA Astrophysics Data System (ADS)

    Gaballah, I.; Dufourg, A.; Tondeur, D.

    2002-11-01

    This paper examines the current and prospective status of education, employment, and sustainable development in the European Union (EU). Due to the decrease of the birth rate and the increase of life expectation, the size of the labor force is decreasing and its average age is increasing. Moreover, rapid technological evolution will necessitate “long-life learning” for the old workers and young people. It will be a challenge to supply the EU’s labor market with an adequate number of workers with the appropriate skill ad tempus. This will change profoundly the classical education system that will become the largest economic sector in the next decade.

  10. EUTELTRACS: The European experience on mobile satellite services

    NASA Technical Reports Server (NTRS)

    Colcy, Jean-Noel; Steinhaeuser, Rafael

    1993-01-01

    EUTELTRACS is Europe's first commercially operated Mobile Satellite Service. Under the overall network operation of EUTELSAT, the European Telecommunications Satellite Organization, EUTELTRACS provides an integrated message exchange and position reporting service. This paper describes the EUTELTRACS system architecture, the message exchange and the position reporting services, including the result of recent analysis of message delivery time and positioning accuracy. It also provides an overview of the commercial deployment, the regulatory situation for its operation within Europe and new applications outside its target market, the international road transportation.

  11. EUTELTRACS: The European experience on mobile satellite services

    NASA Astrophysics Data System (ADS)

    Colcy, Jean-Noel; Steinhaeuser, Rafael

    EUTELTRACS is Europe's first commercially operated Mobile Satellite Service. Under the overall network operation of EUTELSAT, the European Telecommunications Satellite Organization, EUTELTRACS provides an integrated message exchange and position reporting service. This paper describes the EUTELTRACS system architecture, the message exchange and the position reporting services, including the result of recent analysis of message delivery time and positioning accuracy. It also provides an overview of the commercial deployment, the regulatory situation for its operation within Europe and new applications outside its target market, the international road transportation.

  12. Crossed and Locked Quotes in a Multi-Market Simulation.

    PubMed

    Todd, Andrew; Beling, Peter; Scherer, William

    2016-01-01

    Financial markets are often fragmented, introducing the possibility that quotes in identical securities may become crossed or locked. There are a number of theoretical explanations for the existence of crossed and locked quotes, including competition, simultaneous actions, inattentiveness, fee structure and market access. In this paper, we perform a simulation experiment designed to examine the effect of simple order routing procedures on the properties of a fragmented market consisting of a single security trading in two independent limit order books. The quotes in the two markets are connected solely by the routing decision of the market participants. We report on the health of the consolidated market as measured by the duration of crossed and locked states, as well as the spread and the volatility of transaction prices in the consolidated market. We aim to quantify exactly how the prevalence of order routing among a population of market participants affects properties of the consolidated market. Our model contributes to the zero-intelligence literature by treating order routing as an experimental variable. Additionally, we introduce a parsimonious heuristic for limit order routing, allowing us to study the effects of both market order routing and limit order routing. Our model refines intuition for the sometimes subtle relationships between the prevalence of order routing and various market measures. Our model also provides a benchmark for more complex agent-based models.

  13. Hospital marketing orientation and managed care processes: are they coordinated?

    PubMed

    White, K R; Thompson, J M; Patel, U B

    2001-01-01

    The hospital marketing function has been widely adopted as a way to learn about markets, attract sufficient resources, develop appropriate services, and communicate the availability of such goods to those who may be able to purchase such services. The structure, tasks, and effectiveness of the marketing function have been the subject of increased inquiry by researchers and practitioners alike. A specific understanding of hospital marketing in a growing managed care environment and the relationship between marketing and managed care processes in hospitals is a growing concern. Using Kotler and Clarke's framework for assessing marketing orientation, we examined the marketing orientation of hospitals in a single state at two points in time--1993 and 1999. Study findings show that the overall marketing orientation score decreased from 1993 to 1999 for the respondent hospitals. The five elements of the Kotler and Clarke definition of marketing orientation remained relatively stable, with slightly lower scores related to customer philosophy. In addition, we evaluated the degree to which selected managed care activities are carried out as part of its marketing function. A significant (p < .05) decrease in managed care processes coordinated with the formal marketing function was evident from 1993 to 1999. With increasing numbers of managed care plan enrollees, hospitals are likely focusing on organizational buyers as important customers. In order to appeal to organizational buyers, hospital executives may be focusing more on clinical quality and cost efficiency in the production of services, which will improve a hospital's position with organizational buyers.

  14. Crossed and Locked Quotes in a Multi-Market Simulation

    PubMed Central

    Todd, Andrew; Beling, Peter; Scherer, William

    2016-01-01

    Financial markets are often fragmented, introducing the possibility that quotes in identical securities may become crossed or locked. There are a number of theoretical explanations for the existence of crossed and locked quotes, including competition, simultaneous actions, inattentiveness, fee structure and market access. In this paper, we perform a simulation experiment designed to examine the effect of simple order routing procedures on the properties of a fragmented market consisting of a single security trading in two independent limit order books. The quotes in the two markets are connected solely by the routing decision of the market participants. We report on the health of the consolidated market as measured by the duration of crossed and locked states, as well as the spread and the volatility of transaction prices in the consolidated market. We aim to quantify exactly how the prevalence of order routing among a population of market participants affects properties of the consolidated market. Our model contributes to the zero-intelligence literature by treating order routing as an experimental variable. Additionally, we introduce a parsimonious heuristic for limit order routing, allowing us to study the effects of both market order routing and limit order routing. Our model refines intuition for the sometimes subtle relationships between the prevalence of order routing and various market measures. Our model also provides a benchmark for more complex agent-based models. PMID:26959416

  15. Avoiding surprises when implementing a single quality system.

    PubMed

    Donawa, Maria

    2009-01-01

    European medical device manufacturers are sometimes surprised to learn that operating ISO 13485 alone is not sufficient to meet United States (US) quality system requirements. This article discusses important considerations for meeting US and European requirements when operating under a single quality system.

  16. Historians' Rocky Job Market

    ERIC Educational Resources Information Center

    Grafton, Anthony; Townsend, Robert B.

    2008-01-01

    In this article, the authors discuss how the historians' job market is perennially rocky. The history profession had its "golden age" in the 1950s and early 1960s when a generation born in the demographic trench of the Depression entered the market just as the first of the baby boomers began to swell college enrollments. But that moment was…

  17. Buying recycled helps market

    SciTech Connect

    Watts, G.

    1996-08-01

    The waste reduction and recycling program of Thousand Oaks, California is summarized. Descriptions of the program, market development for recycled products, business development, and economic development are provided. The emphasis of the program is on market development for recycled products. Procurement guidelines used by the city are reprinted in the paper.

  18. Outside-Inside Marketing.

    ERIC Educational Resources Information Center

    Carroll, Susan Rovezzi; Carroll, David

    2001-01-01

    Instead of employing "inside-outside" marketing via inhouse brochures, newsletters, and websites, public schools should begin practicing "outside-inside" marketing in which strategic planning and then action comes from the marketplace (the community) to the school. Public perceptions are gathered through surveys, focus groups, and indepth…

  19. Postmodernism and Educational Marketing.

    ERIC Educational Resources Information Center

    Farrell, Francis

    2001-01-01

    Explains two problems of the postmodern era-fragmentation (disintegration of social, economic, and political institutions) and symbolic consumption. Discusses two postmodernist epistemological challenges to educational marketers-anti-foundationalism and poststructuralism. Transactional views of marketing must yield to relational and interactive…

  20. Marketing Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Michigan State Univ., East Lansing. Coll. of Agriculture and Natural Resources Education Inst.

    This curriculum guide is intended to provide a common core of competencies from which to design an effective secondary marketing education program. Introductory materials include a definition of marketing education, objectives, outline of instructional content, and questions and answers regarding the curriculum guide. These practical materials are…

  1. Export markets gain strength

    SciTech Connect

    Fiscor, S.

    2008-02-15

    The prices for internally traded coal in the USA have reached record levels and the future market fundamentals look very good. This is mainly due to Asian demand. The article discusses recent markets for US coal and summarizes findings of a recent study by Hill & Associates entitled 'International coal trade - supply, demand and prices to 2025'. 1 ref., 2 tabs.

  2. Capturing your marketing ROI.

    PubMed

    Spiegelman, Paul

    2003-08-01

    Accurate measurements of marketing ROI can highlight which marketing projects are most effective in enhancing revenue. Calls to call centers can be documented and matched with patient records. Extensive recordkeeping and reporting capabilities are available with call center software packages. Callers to call centers tend to be more engaged than other healthcare consumers.

  3. Creating a Market.

    ERIC Educational Resources Information Center

    Kazimirski, J.; And Others

    The second in a series of programmed books, "Creating a Market" is published by the International Labour Office as a manual for persons studying marketing. This manual was designed to meet the needs of the labor organization's technical cooperation programs and is primarily concerned with consumer goods industries. Using a fill-in-the-blanks and…

  4. Software Marketing Considerations.

    ERIC Educational Resources Information Center

    Fuchs, Victor E.

    Seven factors that currently affect the potential for marketing and publishing computer software for education are discussed: (1) computers as an inplace technology in education, (2) marketing and distribution patterns for software, (3) consumer demand, (4) quality, (5) timelessenss, (6) basic skills, and (7) the future. The proliferation of…

  5. Marketing Schools for Survival

    ERIC Educational Resources Information Center

    Padgett, Raven

    2007-01-01

    Principals desiring recognition in the community have added marketing to their job description. Faced with falling enrollments and more school choice for parents, they create strategies to market and brand their schools to potential parents and students, from promoting programs in school newsletters and websites to direct mailings and ads in real…

  6. Market Madness: Condition Critical

    ERIC Educational Resources Information Center

    Playfair, Eddie

    2015-01-01

    For over a quarter of a century there has been a creeping marketization of the English education system. No part of the system remains unscathed. In this article the consequences of marketization are set out clearly and alternative models of the future are presented. The author calls for another "Great Debate"--but one that mobilises…

  7. Marketing ACE in Victoria.

    ERIC Educational Resources Information Center

    2001

    This publication presents options raised through various forums for marketing adult and community education (ACE) in Victoria, Australia, and suggested strategies. After an introduction (chapter 1), chapters 2 and 3 provide a broad view of the current situation for marketing ACE. Chapter 2 discusses general issues in the current position--ACE…

  8. Marketing Transformation (Fact Sheet)

    SciTech Connect

    DOE Solar Energy Technologies Program

    2011-10-13

    Through the SunShot Initiative, the U.S. Department of Energy (DOE) works with manufacturers, communities, states, utilities, and other partners to enable the solar market by reducing non-hardware balance-of-system (BOS) costs, developing a skilled workforce, and eliminating market barriers to widespread adoption of solar technologies.

  9. Marketing Your Program

    ERIC Educational Resources Information Center

    Anderson, Susan

    2009-01-01

    A marketing plan outlines the specific actions a person intends to carry out to interest potential customers in his/her service and to persuade them to buy the services he/she offers. In other words, a marketing plan defines what his/her organization will do to interest new families in his/her facility and encourage them to enroll their children…

  10. College Access Marketing

    ERIC Educational Resources Information Center

    Tremblay, Christopher W.

    2011-01-01

    College Access Marketing (CAM) is a relatively new phenomenon that seeks to positively influence the college-going rate. This report defines CAM, describes CAM examples, and discusses how CAM seeks to counter barriers to college. It explores four main elements of CAM: information, marketing, advocacy, and social mobilization. Further, it…

  11. Demographics: People and Markets.

    ERIC Educational Resources Information Center

    Merrick, Thomas W.; Tordella, Stephen J.

    1988-01-01

    Population shifts directly affect the bottom line, so the basics of demography are now basic to business as well. Demographics combine demographic data with socioeconomic and geographic factors to help business and other managers know the market for the goods and services they offer. This guide explains market, product, and site analyses,…

  12. A Stock Market Project.

    ERIC Educational Resources Information Center

    Anderson, Christine; Cook, Stan

    1990-01-01

    Offers a field-tested stock market unit designed to develop mathematical skills involving fractions and decimals, basic understanding of the stock market, and hypothesis testing skills in real world situations. Includes tables displaying questions, tally sheets, and instructions, as well as a list of related activities. (MDH)

  13. Marketing Higher Education.

    ERIC Educational Resources Information Center

    Knight, Brent; Johnson, Dennis

    1981-01-01

    In a successful college marketing program, students and high-quality instruction are top priorities. Marketing research should investigate student needs and frustrations, the products offered, value received for time and money invested, physical convenience and appeal, and promotional strategies. Program research and development suggestions are…

  14. The Marketing of Margaret.

    ERIC Educational Resources Information Center

    Elebash, Camille

    The 1983 British general election saw greater use than ever before in that country of sophisticated marketing research and techniques in the promotion of a party (the Conservatives) and a personality (Margaret Thatcher). With the help of an outside advertising agency, the Conservative Central Office had more marketing expertise than ever before,…

  15. Deployment & Market Transformation (Brochure)

    SciTech Connect

    Not Available

    2012-04-01

    NREL's deployment and market transformation (D and MT) activities encompass the laboratory's full range of technologies, which span the energy efficiency and renewable energy spectrum. NREL staff educates partners on how they can advance sustainable energy applications and also provides clients with best practices for reducing barriers to innovation and market transformation.

  16. Differential pricing of new pharmaceuticals in lower income European countries.

    PubMed

    Kaló, Zoltán; Annemans, Lieven; Garrison, Louis P

    2013-12-01

    Pharmaceutical companies adjust the pricing strategy of innovative medicines to the imperatives of their major markets. The ability of payers to influence the ex-factory price of new drugs depends on country population size and income per capita, among other factors. Differential pricing based on Ramsey principles is a 'second-best' solution to correct the imperfections of the global market for innovative pharmaceuticals, and it is also consistent with standard norms of equity. This analysis summarizes the boundaries of differential pharmaceutical pricing for policymakers, payers and other stakeholders in lower-income countries, with special focus on Central-Eastern Europe, and describes the feasibility and implications of potential solutions to ensure lower pharmaceutical prices as compared to higher-income countries. European stakeholders, especially in Central-Eastern Europe and at the EU level, should understand the implications of increased transparency of pricing and should develop solutions to prevent the limited accessibility of new medicines in lower-income countries.

  17. EDITORIAL: The 15th Central European Workshop on Quantum Optics The 15th Central European Workshop on Quantum Optics

    NASA Astrophysics Data System (ADS)

    Bozic, Mirjana; Man'ko, Margarita; Arsenovic, Dusan

    2009-07-01

    The development of quantum optics was part and parcel of the formation of modern physics following the fundamental work of Max Planck and Albert Einstein, which gave rise to quantum mechanics. The possibility of working with pure quantum objects, like single atoms and single photons, has turned quantum optics into the main tool for testing the fundamentals of quantum physics. Thus, despite a long history, quantum optics nowadays remains an extremely important branch of physics. It represents a natural base for the development of advanced technologies, like quantum information processing and quantum computing. Previous Central European Workshops on Quantum Optics (CEWQO) took place in Palermo (2007), Vienna (2006), Ankara (2005), Trieste (2004), Rostock (2003), Szeged (2002), Prague (2001), Balatonfüred (2000), Olomouc (1999), Prague (1997), Budmerice (1995, 1996), Budapest (1994) and Bratislava (1993). Those meetings offered excellent opportunities for the exchange of knowledge and ideas between leading scientists and young researchers in quantum optics, foundations of quantum mechanics, cavity quantum electrodynamics, photonics, atom optics, condensed matter optics, and quantum informatics, etc. The collaborative spirit and tradition of CEWQO were a great inspiration and help to the Institute of Physics, Belgrade, and the Serbian Academy of Sciences and Arts, as the organizers of CEWQO 2008. The 16th CEWQO will take place in 2009 in Turku, Finland, and the 17th CEWQO will be organized in 2010 in St Andrews, United Kingdom. The 15th CEWQO was organized under the auspices and support of the Ministry of Science of the Republic of Serbia, the Serbian Physical Society, the European Physical Society with sponsorship from the University of Belgrade, the Central European Initiative, the FP6 Program of the European Commission under INCO project QUPOM No 026322, the FP7 Program of the European Commission under project NANOCHARM, Europhysics Letters (EPL), The European

  18. Space Service Market (Theoretical Aspect)

    NASA Astrophysics Data System (ADS)

    Prisniakov, V. F.; Prisniakova, L. M.

    The authors propose a mathematical model of the demand and supply in the market economics and in the market of space services, in particular. A theoretical demand formula and a real curve demand are compared. The market equilibrium price is defined. The space market dynamics is studied. The calculations are carried out for the parameters which are close to the market of space services.

  19. How Can Marketing Academics Serve Marketing Practice? The New Marketing DNA as a Model for Marketing Education

    ERIC Educational Resources Information Center

    Harrigan, Paul; Hulbert, Bev

    2011-01-01

    This article seeks to address how marketing academics can best serve marketing practice through marketing education. It is contended that, where technology is driving marketing in practice, it is afforded significantly less attention in both theory and education. Thus, the marketing graduates being produced from universities are often lacking in…

  20. Marketing Prior Learning Assessment Programs.

    ERIC Educational Resources Information Center

    Heeger, Gerald A.

    1983-01-01

    Experiential learning programs must be marketed effectively if they are to succeed. The formulation of market strategy is discussed including: strategic planning; identification of a market target; and development of a market mix. A commitment to marketing academic programs is seen as a commitment to self-assessment. (MW)

  1. A Critical Analysis of Concentration and Competition in the Indian Pharmaceutical Market

    PubMed Central

    Mehta, Aashna; Hasan Farooqui, Habib; Selvaraj, Sakthivel

    2016-01-01

    Objectives It can be argued that with several players marketing a large number of brands, the pharmaceutical market in India is competitive. However, the pharmaceutical market should not be studied as a single market but, as a sum total of a large number of individual sub-markets. This paper examines the methodological issues with respect to defining the relevant market involved in studying concentration in the pharmaceutical market in India. Further, we have examined whether the Indian pharmaceutical market is competitive. Methods Indian pharmaceutical market was studied using PharmaTrac, the sales audit data from AIOCD-AWACS, that organises formulations into 5 levels of therapeutic classification based on the EphMRA system. The Herfindahl-Hirschman Index (HHI) was used as the indicator of market concentration. We calculated HHI for the entire pharmaceutical market studied as a single market as well as at the five different levels of therapeutic classification. Results and Discussion Whereas the entire pharmaceutical market taken together as a single market displayed low concentration (HHI = 226.63), it was observed that if each formulation is defined as an individual sub-market, about 69 percent of the total market in terms of market value displayed at least moderate concentration. Market should be defined taking into account the ease of substitutability. Since, patients cannot themselves substitute the formulation prescribed by the doctor with another formulation with the same indication and therapeutic effect, owing to information asymmetry, it is appropriate to study market concentration at the narrower levels of therapeutic classification. PMID:26895269

  2. Kreuth III: European consensus proposals for treatment of haemophilia with coagulation factor concentrates.

    PubMed

    Giangrande, P; Seitz, R; Behr-Gross, M E; Berger, K; Hilger, A; Klein, H; Schramm, W; Mannucci, P M

    2014-05-01

    This report summarizes recommendations relating to haemophilia therapy arising from discussions among experts from 36 European countries during the Kreuth III meeting in April 2013. To optimize the organization of haemophilia care nationally, it is recommended that a formal body be established in each country to include the relevant clinicians, national haemophilia patient organization, health ministry, paying authority and (if appropriate) regulatory authorities. The minimum factor VIII consumption level in a country should be 3 I.U. per capita. Decisions on whether to adopt a new product should not be based solely on cost. Prophylaxis for children with severe haemophilia is already recognized as the optimum therapy. Ongoing prophylaxis for individual adults should also be provided when required based on clinical decision making by the clinician in consultation with the patient. Children with inhibitors who have failed, or who are not suitable for, immune tolerance therapy should be offered prophylaxis with bypassing agents. Single factor concentrates should be used as therapy wherever possible in patients with rare bleeding disorders. Orphan drug designation for a factor concentrate should not be used to hinder the development, licencing and marketing of other products for the same condition which have demonstrably different protein modification or enhancement.

  3. European courts and old people.

    PubMed

    Mulley, Graham P

    2013-09-01

    There are two major European Courts, the European Court of Justice (ECJ) and the European Court of Human Rights (ECHR). The ECJ deals with legal matters, mainly involving the interpretation of EU law and ensuring that the law is applied evenly across all 27 EU member states. The ECHR aims to make certain that civil and political rights of citizens in the 46 member states of the Council of Europe are observed. Most cases involving older citizens are about social policy (such as pension arrangements, equality, age discrimination and mandatory retirement). There have been few cases dealing with patients' rights, long-term care or housing. Referrals of selected cases involving old people should be considered if their rights are not being protected. In this Commentary, there is an account of how these Courts have evolved, together with guidance on whom to refer, to which Court, and when and how referrals should be made.

  4. Susceptibility of juvenile European lobster Homarus gammarus to shrimp products infected with high and low doses of white spot syndrome virus.

    PubMed

    Bateman, K S; Munro, J; Uglow, B; Small, H J; Stentiford, G D

    2012-08-27

    White spot syndrome virus (WSSV) is the most important pathogen known to affect the sustainability and growth of the global penaeid shrimp farming industry. Although most commonly associated with penaeid shrimp farmed in warm waters, WSSV is also able to infect, cause disease in and kill a wide range of other decapod crustaceans, including lobsters, from temperate regions. In 2005, the European Union imported US$500 million worth of raw frozen or cooked frozen commodity products, much of which originated in regions positive for white spot disease (WSD). The presence of WSSV within the UK food market was verified by means of nested PCR performed on samples collected from a small-scale survey of supermarket commodity shrimp. Passage trials using inoculum derived from commodity shrimp from supermarkets and delivered by injection to specific pathogen-free Pacific white shrimp Litopenaeus vannamei led to rapid mortality and pathognomonic signs of WSD in the shrimp, demonstrating that WSSV present within commodity shrimp was viable. We exposed a representative European decapod crustacean, the European lobster Homarus gammarus, to a single feeding of WSSV-positive, supermarket-derived commodity shrimp, and to positive control material (L. vannamei infected with a high dose of WSSV). These trials demonstrated that lobsters fed positive control (high dose) frozen raw products succumbed to WSD and displayed pathognomonic signs associated with the disease as determined by means of histology and transmission electron microscopy. Lobsters fed WSSV-positive, supermarket-derived commodity shrimp (low dose) did not succumb to WSD (no mortality or pathognomonic signs of WSD) but demonstrated a low level or latent infection via PCR. This study confirms susceptibility of H. gammarus to WSSV via single feedings of previously frozen raw shrimp products obtained directly from supermarkets.

  5. Education, mental health, and education-labor market misfit.

    PubMed

    Bracke, Piet; van de Straat, Vera; Missinne, Sarah

    2014-12-01

    Higher-educated people experience enhanced mental health. We ponder whether the mental health benefits of educational attainment are limitless. At the individual level, we look at the impact of job-education mismatch. At the societal level, we hypothesize that diminishing economic returns on education limit its mental health benefits. Using a subsample of individuals aged 20 to 65 years (N = 28,288) from 21 countries in the European Social Survey (ESS 2006), we estimate the impact on depressive symptoms of characteristics at both the employee level (years of education and job-education mismatch) and the labor market/country level (the gap between the nontertiary and tertiary educated in terms of unemployment risks and earnings). The results show that educational attainment produces mental health benefits in most European countries. However, in some of the countries, these benefits are limited or even completely eliminated by education-labor market misfit.

  6. Physician Labor Market in Croatia

    PubMed Central

    Bagat, Mario; Sekelj Kauzlarić, Katarina

    2006-01-01

    Aim To analyze the physician labor market in Croatia with respect to the internship and employment opportunities, Croatian needs for physicians and specialists, and trends in physician labor market in the European Union (EU) in the context of EU enlargement. Methods Data were collected from the Ministry of Health and Social Welfare, the Croatian Employment Service, and the Croatian Institute for Public Health. We compared the number of physicians waiting for internship before and 14 months after the implementation of the State Program for Intern Employment Stimulation. Also, the number of employed specialists in internal medicine, general surgery, gynecology and obstetrics, and pediatrics was compared with estimated number of specialists that will have been needed by the end of 2007. Average age of hospital physicians in the four specialties was determined and the number of Croatian physicians compared with the number of physicians in EU countries. Results The number of unemployed physicians waiting for internship decreased from 335 in 2003 to 82 in 2004, while a total number of unemployed physicians decreased from 436 to 379 (χ2 = 338, P<0.001). In October 2004, 79.3% of unemployed physicians waited for internship <6 months; of them, 89.2% waited for internship <3 months. In February 2005, 365 unemployed physicians were registered at the Croatian Employment Service and that number has been decreasing in the last couple of years. The number of employed specialists was lower than the estimated number of specialists needed in the analyzed specialists, as defined by the prescribed standards. A shortage of 328 internists, 319 surgeons, 209 gynecologists, and 69 pediatricians in Croatian hospitals is expected in 2007. Conclusion The lack of employment incentive seems to be the main reason for the large number of unemployed physicians waiting for internship before the implementation of the Employment Stimulation Program. According to the number of physicians per 100

  7. European Union a New Babylon?

    NASA Astrophysics Data System (ADS)

    Mesch, F.

    2010-07-01

    The growing European Union faces growing problems in personal communication. These problems cannot be overcome only by more language courses in school. As important is a better mutual knowledge of the culture of other countries, a knowledge that can be gained only by a personal, professional stay in foreign countries. On university level, such stays are best organized by networks connecting European universities. In the broad field of measurement, this IMEKO symposium might offer a unique forum to thoroughly discuss structure and realization of such a network with all interested colleagues.

  8. [The European mouflon, Ovis musimon].

    PubMed

    Hermans, W A

    1996-09-15

    Until a couple of decades ago, the European mouflon found on the islands of Corsica, Sardinia, and Cyprus was considered an independent wild species and last representative of the European wild sheep. However, recent research has shown that there have not been wild sheep in Europe since the late Pleistocene. Archeological investigation in Corsica has shown that the mouflon is not a wild sheep but a primitive domestic sheep brought to the islands by farmers from the Near East and which then became wild (feral).

  9. Interactions between European Citizenship and Language Learning among Adolescent Europeans

    ERIC Educational Resources Information Center

    Hennebry, Mairin

    2011-01-01

    Recent enlargement of the European Union (EU) has created debate as to the suitability of current structures and policies for effectively engaging citizens and developing social cohesion. Education and specifically modern foreign language (MFL) teaching are argued by the literature to play a key role in equipping young people to interact and…

  10. Diagrams of Europeanization: European Education Governance in the Digital Age

    ERIC Educational Resources Information Center

    Decuypere, Mathias

    2016-01-01

    European education governance is increasingly affected by and effectuated through digital means. This article presents an analysis of the way in which Europe is increasingly deploying digital technologies, and more specifically websites, in order to shape and communicate its education policies. Drawing on the notion of the diagram as the…

  11. The Use of Marketing Techniques to Facilitate Acceptance of Parent Education Programs: A Case Example.

    ERIC Educational Resources Information Center

    Levant, Ronald F.

    1987-01-01

    Presents case example to illustrate use of market assessment to inform the marketing of preventive parenting programs for fathers, working parents, single parents, and stepparents. Discusses results from survey of 300 parents in terms of how findings can be used in marketing areas of product, price, place, and promotion. (Author/NB)

  12. Sod Production and Marketing. Instructional Materials Developed for Iowa Vocational Agriculture Teachers.

    ERIC Educational Resources Information Center

    Iowa State Univ. of Science and Technology, Ames. Dept. of Agricultural Education.

    Developed for use by vocational agriculture teachers in Iowa, this instructional unit provides information about the growing and marketing of sod for lawns. This document is one of three manuals making up a single package. (The other two are Christmas Tree Production and Marketing and Sod Production and Marketing). The manual includes an…

  13. Ancillary services market in California

    SciTech Connect

    Gomez, T.; Marnay, C.; Siddiqui, A.; Liew, L.; Khavkin, M.

    1999-07-01

    This report includes sections on the following topics: (1) California restructured electricity system overview; (2) Reliability criteria; (3) Design of the California ISO ancillary services market; (4) Operation of ancillary services markets; (5) Ancillary services markets redesign; and (6) Conclusions.

  14. Is the pharmaceutical market in Bulgaria innovative?

    PubMed

    Stoimenova, A; Stankova, M; Samev, K; Petrova, G

    2003-09-01

    After the turn to market oriented economy a lot of drugs were authorized for sale in the East European countries. Because of the limited resources of these countries, mainly generic or brand generic products were licensed. The number of the patented drugs on the market could be used as measure of the market attractiveness to the R&D producers. The study shows the analysis of the innovativeness of the Bulgarian drug market comparing the registration and the patient activity of the producers. The number of the authorized products for five years period (1990-2000) and share of the patented products were investigated. During the observed period the number of newly authorized pharmaceuticals increased almost seven times from 800 (650 INN) to 6000 (2000 INN) dosage forms. The prevailing part of the newly registered drugs was found to be brand generics and possess only trade name protection. The share of drugs that are patented is less than five percent of all newly registered medicines, and among the fifty most commonly prescribed and sold medicines between 1996-2000, only 0.5 percent of drugs were patented. Obviously the Bulgarian pharmaceutical market is very competitive but not that attractive for most of the R&D producers. In general the registration of the patent protected products is increasing during the years and especially after harmonization of the related legislation with the EU requirements. The patent activity of the pharmaceutical companies regarding newly authorized drugs is influenced by the structure of morbidity and population. During the last two years the patent activity is increasing and is oriented mainly towards the protection of newly authorized drugs or pharmaceutical forms and obligatory registration of trademarks for the privatized Bulgarian pharmaceutical manufacturers.

  15. Evolutionary financial market models

    NASA Astrophysics Data System (ADS)

    Ponzi, A.; Aizawa, Y.

    2000-12-01

    We study computer simulations of two financial market models, the second a simplified model of the first. The first is a model of the self-organized formation and breakup of crowds of traders, motivated by the dynamics of competitive evolving systems which shows interesting self-organized critical (SOC)-type behaviour without any fine tuning of control parameters. This SOC-type avalanching and stasis appear as realistic volatility clustering in the price returns time series. The market becomes highly ordered at ‘crashes’ but gradually loses this order through randomization during the intervening stasis periods. The second model is a model of stocks interacting through a competitive evolutionary dynamic in a common stock exchange. This model shows a self-organized ‘market-confidence’. When this is high the market is stable but when it gets low the market may become highly volatile. Volatile bursts rapidly increase the market confidence again. This model shows a phase transition as temperature parameter is varied. The price returns time series in the transition region is very realistic power-law truncated Levy distribution with clustered volatility and volatility superdiffusion. This model also shows generally positive stock cross-correlations as is observed in real markets. This model may shed some light on why such phenomena are observed.

  16. High level of mislabeling in Spanish and Greek hake markets suggests the fraudulent introduction of African species.

    PubMed

    Garcia-Vazquez, Eva; Perez, Juliana; Martinez, Jose L; Pardiñas, Antonio F; Lopez, Belen; Karaiskou, Nikoletta; Casa, Mary F; Machado-Schiaffino, Gonzalo; Triantafyllidis, Alexander

    2011-01-26

    DNA analysis of hake products commercialized in southern European (Spanish and Greek) market chains have demonstrated more than 30% mislabeling, on the basis of species substitution. Tails and fillets were more mislabeled than other products, such as slices and whole pieces. African species were substitute species for products labeled as American and European species, and we suggest it is a case of deliberate economically profitable mislabeling because real market prices of European and American hake products are higher than those of African in Spanish market chains. The presented results suggest fraud detection that disadvantages African producers. Government-mandated genetic surveys of commercial hakes and the use of subsequent statements of fair trade on labels of seafood products could help to reduce fraud levels in a global market of increasingly conscious consumers sensitive to ethical issues.

  17. The future of European Communications Satellites

    NASA Astrophysics Data System (ADS)

    Morris, R.

    1984-02-01

    The paper, which is based on the work of a Eurospace Study Group on future prospects, reviews the problems arising from the introduction of new technologies in the industrial process of developing and manufacturing communications satellites, covering the topics of engineering, manufacturing, integration and test, and in-space management. It continues by considering the commerical and industrial problems encountered by European manufacturers, and the contractual and legal problems arising from the change of customer base, from ESA to user organizations, and from the political problems which stem from cross-border transmission of TV broadcasting and data transfer. It then considers the marketing problems of the spacecraft manufacturer - his remoteness from the end-user of telecommunications circuits, the competition from new technology in conventional communications, and the intense competition from U.S. competitors, who have the advantage of both military and domestic and international civil programs on which to develop technology. It concludes with a brief review of current and future spacecraft developments by British Aerospace, and some possible communications satellite configurations for the 1990's.

  18. Pharmaceutical regulation in 15 European countries review.

    PubMed

    Panteli, Dimitra; Arickx, Francis; Cleemput, Irina; Dedet, Guillaume; Eckhardt, Helen; Fogarty, Emer; Gerkens, Sophie; Henschke, Cornelia; Hislop, Jennifer; Jommi, Claudio; Kaitelidou, Daphne; Kawalec, Pawel; Keskimaki, Ilmo; Kroneman, Madelon; Lopez Bastida, Julio; Pita Barros, Pedro; Ramsberg, Joakim; Schneider, Peter; Spillane, Susan; Vogler, Sabine; Vuorenkoski, Lauri; Wallach Kildemoes, Helle; Wouters, Olivier; Busse, Reinhard

    2016-10-01

    In the context of pharmaceutical care, policy-makers repeatedly face the challenge of balancing patient access to effective medicines with affordability and rising costs. With the aim of guiding the health policy discourse towards questions that are important to actual and potential patients, this study investigates a broad range of regulatory measures, spanning marketing authorization to generic substitution and resulting price levels in a sample of 16 European health systems (Austria, Belgium, Denmark, England, Finland, France, Germany, Greece, Ireland, Italy, the Netherlands, Poland, Portugal, Scotland, Spain and Sweden). All countries employ a mix of regulatory mechanisms to contain pharmaceutical expenditure and ensure quality and efficiency in pharmaceutical care, albeit with varying configurations and rigour. This variation also influences the extent of publicly financed pharmaceutical costs. Overall, observed differences in pharmaceutical expenditure should be interpreted in conjunction with the differing volume and composition of consumption and price levels, as well as dispensation practices and their impact on measurement of pharmaceutical costs. No definitive evidence has yet been produced on the effects of different cost-containment measures on patient outcomes. Depending on the foremost policy concerns in each country, different levers will have to be used to enable the delivery of appropriate care at affordable prices.

  19. Tobacco and the European common agricultural policy.

    PubMed

    Joossens, L; Raw, M

    1991-10-01

    The common agricultural policy of the European Community subsidizes tobacco production to the tune of 1,300 million ecu a year (US$ 1,500 million, UK pounds 900 million). This amounts to 2,500 ecu ($3,100, pounds 1,700) per minute, and is more in one year than the total amount spent on tobacco subsidies by the US in the last 50 years. The purpose of this policy was to maintain farmers' incomes and adapt community production to demand. Demand for the dark tobaccos which dominate EC production has fallen, while demand for light flue cured tobacco like Virginia has risen. A complex system of production subsidies and quotas was intended to discourage production of the dark tobaccos, for which there is virtually no market, and lead to more Virginia production. The policy has failed. Expenditure has spiralled out of control, production of unmarketable tobacco varieties has risen enormously, and the EC is the world's largest importer of raw tobacco. As a result tobacco is being bought by the community for intervention storage and surpluses of the dark high tar varieties are being 'exported' to eastern Europe and north Africa at giveaway prices. There has been no effective monitoring or control of this policy. This paper explains how this has happened and argues that, in view of the health risks attached to tobacco, these subsidies should be abolished.

  20. [Viral safety: European and French directives].

    PubMed

    Rossi, F; Legras, J F

    2000-05-01

    The viral safety of IVIg is defined by transposition of European Directives. Directive 89/381/CEE defines plasma-derived medicinal products (pd-MP) which should be registred through a Marketing Authorization (75/318/CEE) and requires specific criteria for donation acceptability and fractionation processing. Recommendations and Notes for Guidance are prepared by the "Biotechnology Working Party" (BWP), Committee for Proprietary Medicinal Products (CPMP) ad hoc group. "Note for Guidance on Virus Validation Studies: CPMP/BWP/268/95" defines, for conventional viruses, the validation study as regards viral elimination /inactivation steps (relevant virus, scale reduction system and statistical interpretation of the results). "Note for Guidance on 'blood products'- CPMP/BWP/269/95" defines the key issues of viral safety: starting material, viral elimination /inactivation steps within the fractionation processing and in process controls. Pd-MP used as excipients are also covered. BWP/CPMP recommends that exclusion criteria only be considered for sporadic, familial or iatrogenic Creutzfeldt-Jakob disease (CJD), while withdrawal should be undertaken, according to the precaution principle, when a donor is suffering from nv-CJD (February 1998). Also, screening tests currently under development for transmissible spongiform encephalopathies are encouraged to be introduced for fractionation products (January 1999). Some donor exclusion criteria for conventional viruses and prions are specific to France. In conclusion, measures taken to ensure pd-MP viral safety are constantly changing. Its evaluation can only be done when considering numerous parameters within a global context.

  1. Choice policies in Northern European health systems.

    PubMed

    Vrangbaek, Karsten; Robertson, Ruth; Winblad, Ulrika; Van de Bovenkamp, Hester; Dixon, Anna

    2012-01-01

    This paper compares the introduction of policies to promote or strengthen patient choice in four Northern European countries - Denmark, England, the Netherlands and Sweden. The paper examines whether there has been convergence in choice policies across Northern Europe. Following Christopher Pollitt's suggestion, the paper distinguishes between rhetorical (discursive) convergence, decision (design) convergence and implementation (operational) convergence (Pollitt, 2002). This leads to the following research question for the article: Is the introduction of policies to strengthen choice in the four countries characterised by discursive, decision and operational convergence? The paper concludes that there seems to be convergence among these four countries in the overall policy rhetoric about the objectives associated with patient choice, embracing both concepts of empowerment (the intrinsic value) and market competition (the instrumental value). It appears that the institutional context and policy concerns such as waiting times have been important in affecting the timing of the introduction of choice policies and implementation, but less so in the design of choice policies. An analysis of the impact of choice policies is beyond the scope of this paper, but it is concluded that further research should investigate how the institutional context and timing of implementation affect differences in how the choice policy works out in practice.

  2. Market research for electric utilities

    SciTech Connect

    Shippee, G.

    1999-12-01

    Marketing research is increasing in importance as utilities become more marketing oriented. Marketing research managers need to maintain autonomy from the marketing director or ad agency and make sure their work is relevant to the utility's operation. This article will outline a model marketing research program for an electric utility. While a utility may not conduct each and every type of research described, the programs presented offer a smorgasbord of activities which successful electric utility marketers often use or have access to.

  3. Demonstrating marketing accountability.

    PubMed

    Gombeski, William R; Britt, Jason; Taylor, Jan; Riggs, Karen; Wray, Tanya; Adkins, Wanda; Springate, Suzanne

    2008-01-01

    Pressure on health care marketers to demonstrate effectiveness of their strategies and show their contribution to organizational goals is growing. A seven-tiered model based on the concepts of structure (having the right people, systems), process (doing the right things in the right way), and outcomes (results) is discussed. Examples of measures for each tier are provided and the benefits of using the model as a tool for measuring, organizing, tracking, and communicating appropriate information are provided. The model also provides a framework for helping management understand marketing's value and can serve as a vehicle for demonstrating marketing accountability.

  4. a Cultural Market Model

    NASA Astrophysics Data System (ADS)

    HerdaǦDELEN, Amaç; Bingol, Haluk

    Social interactions and personal tastes shape our consumption behavior of cultural products. In this study, we present a computational model of a cultural market and we aim to analyze the behavior of the consumer population as an emergent phenomena. Our results suggest that the final market shares of cultural products dramatically depend on consumer heterogeneity and social interaction pressure. Furthermore, the relation between the resulting market shares and social interaction is robust with respect to a wide range of variation in the parameter values and the type of topology.

  5. Increasing market efficiency in the stock markets

    NASA Astrophysics Data System (ADS)

    Yang, Jae-Suk; Kwak, Wooseop; Kaizoji, Taisei; Kim, In-Mook

    2008-01-01

    We study the temporal evolutions of three stock markets; Standard and Poor's 500 index, Nikkei 225 Stock Average, and the Korea Composite Stock Price Index. We observe that the probability density function of the log-return has a fat tail but the tail index has been increasing continuously in recent years. We have also found that the variance of the autocorrelation function, the scaling exponent of the standard deviation, and the statistical complexity decrease, but that the entropy density increases as time goes over time. We introduce a modified microscopic spin model and simulate the model to confirm such increasing and decreasing tendencies in statistical quantities. These findings indicate that these three stock markets are becoming more efficient.

  6. Mathematical Modelling in European Education

    ERIC Educational Resources Information Center

    Ferri, Rita Borromeo

    2013-01-01

    Teaching and learning of mathematical modelling has become a key competence within school curricula and educational standards in many countries of the world. The term mathematical modelling, its meaning, and how it can be implemented in mathematics lessons have been intensively discussed during several Conferences of the European Society for…

  7. Reconstructing Indo-European Syllabification

    ERIC Educational Resources Information Center

    Byrd, Andrew Miles

    2010-01-01

    The chief concern of this dissertation is to investigate a fundamental, yet unsolved problem within the phonology of Proto-Indo-European (PIE): the process of syllabification. I show that by analyzing the much more easily reconstructable word-edge clusters we may predict which types of consonant clusters can occur word-medially, provided that we…

  8. Attitudes of Europeans toward Age.

    ERIC Educational Resources Information Center

    Ageing International, 1993

    1993-01-01

    Two Commission of European Communities surveys of people over age 15 and of those over 60 demonstrated a widespread belief that older people deserve public support and services and face employment discrimination. Socioeconomic factors influenced older people's sense of security and life satisfaction. Positive intergenerational attitudes appeared.…

  9. European Year of Languages, 2001.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Directorate of Education, Culture and Sport, Documentation Section.

    This document is a folder full of brochures describing the activities of Council of Europe and the European Union to celebrate 2001 as a year of languages in order to celebrate the linguistic diversity of Europe and promote the many opportunities available for lifelong language learning. A number of facts and figures about the languages of Europe…

  10. Scholarships for European vet students.

    PubMed

    Egan, Jordon; Takacs, Daniella

    2017-02-25

    Every year, students from European vet schools can apply for $5000 scholarships, which aim to 'enhance the academic experience of students'. Among last year's recipients were Jordon Egan, from the Royal Veterinary College, and Daniella Takács, from the University of Veterinary Medicine in Budapest.

  11. European urology: quality, impact, online.

    PubMed

    Catto, James W F; Montorsi, Francesco; Schulman, Claude

    2013-10-01

    European Urology provides contemporary, cutting-edge urologic research, guidance, and discussion. The journal continues to invite collaborative reviews, to invest in rapid but fair peer review, to seek the best research, and to serve the needs of readers and patients.

  12. Beyond "Ability": Some European Alternatives

    ERIC Educational Resources Information Center

    Wrigley, Terry

    2013-01-01

    This article draws on European approaches to differentiation that do not entail fatalistic determinism. It describes two challenging initiatives in Denmark, where democratic learning and learning for democracy are enshrined in law. Other examples come from Germany, from the Bielefeld laboratory school and a sixth form college, where planning for…

  13. European tests on materials outgassing

    NASA Technical Reports Server (NTRS)

    Zwaal, A.

    1977-01-01

    With a view to international coordination of spacecraft materials, a number of European firms and institutes performed outgassing tests on identical materials at 125 C in high vacuum. The outgassing data obtained with the different types of equipment is presented and both the results and the critical parameters are discussed.

  14. The European Location Framework - from National to European

    NASA Astrophysics Data System (ADS)

    Pauknerova, E.; Sidlichovsky, P.; Urbanas, S.; Med, M.

    2016-06-01

    The European Location Framework (ELF) means a technical infrastructure which will deliver authoritative, interoperable geospatial reference data from all over Europe for analysing and understanding information connected to places and features. The ELF has been developed and set up through the ELF Project, which has been realized by a consortium of partners (public, private and academic organisations) since March 2013. Their number increased from thirty to forty in the year 2016, together with a project extension from 36 to 44 months. The project is co-funded by the European Commission's Competitiveness and Innovation Framework Programme (CIP) and will end in October 2016. In broad terms, the ELF Project will deliver a unique gateway to the authoritative reference geospatial information for Europe (harmonised pan-European maps, geographic and land information) sourced from the National Mapping and Cadastral Authorities (NMCAs) around Europe and including transparent licensing. This will be provided as an online ELF web service that will deliver an up-to-date topographic base map and also as view & download services for access to the ELF datasets. To develop and build up the ELF, NMCAs are accompanied and collaborate with several research & academia institutes, a standardisation body, system integrators, software developers and application providers. The harmonisation is in progress developing and triggering a number of geo-tools like edge-matching, generalisation, transformation and others. ELF will provide also some centralised tools like Geo Locator for searching location based on geographical names, addresses and administrative units, and GeoProduct Finder for discovering the available web-services and licensing them. ELF combines national reference geo-information through the ELF platform. ELF web services will be offered to users and application developers through open source (OSKARI) and proprietary (ArcGIS Online) cloud platforms. Recently, 29 NMCAs plus the

  15. Multivariate Comparative Analysis of Stock Exchanges: The European Perspective

    NASA Astrophysics Data System (ADS)

    Koralun-Bereźnicka, Julia

    The aim of the research is to perform a multivariate comparative analysis of 20 European stock exchanges in order to identify the main similarities between the objects. Due to the convergence process of capital markets in Europe the similarities between stock exchanges could be expected to increase over time. The research is meant to show whether and how these similarities change. Consequently, the distances between clusters of similar stock exchanges should become less significant, which the analysis also aims at verifying. The basis of comparison is a set of 48 monthly variables from the period January, 2003 to December, 2006. The variables are classified into three categories: size of the market, equity trading and bonds. The paper aims at identifying the clusters of alike stock exchanges and at finding the characteristic features of each of the distinguished groups. The obtained categorization to some extent corresponds with the division of the European Union into “new” and “old” member countries. Clustering method, performed for each quarter separately, also reveals that the classification is fairly stable in time. The factor analysis, which was carried out to reduce the number of variables, reveals three major factors behind the data, which are related with the earlier mentioned categories of variables.

  16. Flooding the market

    NASA Astrophysics Data System (ADS)

    Horn, Diane; McShane, Michael

    2013-11-01

    A flood insurance market with risk-based prices in the UK will only stimulate climate change adaptation if it is part of a wider strategy that includes land-use planning, building regulations and water management.

  17. History of Voluntary Markets

    EPA Pesticide Factsheets

    Renewable energy generation ownership can be accounted through tracking systems. Tracking systems are highly automated, contain specific information about each MWh, and are accessible over the internet to market participants.

  18. Marketing the Library.

    ERIC Educational Resources Information Center

    Dragon, Andrea C.

    1979-01-01

    Describes the positive action using marketing strategies that libraries must take to capture their share of the post-Proposition 13 tax dollar. Strategies discussed relate to price, product, promotion, and place. (JD)

  19. Marketing Trends to Watch

    ERIC Educational Resources Information Center

    Circle, Alison

    2009-01-01

    This article identifies 13 cultural trends that libraries can turn into opportunites to reach patrons. These trends include: Twitter, online reputation management, value added content, mobile marketing, and emotional connection.

  20. Marketing School Food Services.

    ERIC Educational Resources Information Center

    Wood, Wilma

    1990-01-01

    Marketing the food service program in an Ohio district is directed toward the students and also at the community, school administrators, teachers, and employees. Students are encouraged to follow a healthier way of eating. (MLF)