Science.gov

Sample records for single transient test

  1. Columbia University flow instability experimental program: Volume 6. Single annulus tests, transient test program

    SciTech Connect

    Dougherty, T.; Maciuca, C.; McAssey, E.V. Jr.; Reddy, D.G.; Yang, B.W.

    1992-09-01

    The coolant in the Savannah River Site (SRS) production nuclear reactor assemblies is circulated as a subcooled liquid under normal operating conditions. This coolant is evenly distributed throughout multiple annular flow channels with a uniform pressure profile across each coolant flow channel. During the postulated Loss of Coolant Accident (LOCA), which is initiated by a hypothetical guillotine pipe break, the coolant flow through the reactor assemblies is significantly reduced. The flow reduction and accompanying power reduction (after shutdown is initiated) occur in the first 1 to 2 seconds of the LOCA. This portion of the LOCA is referred to as the Flow Instability phase. This report presents the experimental results for the transient portion of the single annulus test program. The test program was designed to investigate the onset of flow instability in an annular geometry similar to the MARK 22 reactor. The test program involved testing of both a ribless heater and a ribbed heater under steady state as well as transient conditions. The ribbed heater testing is currently underway and will be reported separately. The steady state portion of this test program with ribless heater was completed and reported in report No. CU-HTRF-T3A. The present report presents transient test results obtained from a ribless, uniform annulus test section. A total of thirty five transients were conducted with six cases in which flow excursion occurred. No unstable conditions resulted for tests in which the steady state Q{sub ratio} OFI limit was not exceeded.

  2. Analysis of the single-blow transient testing technique for perforated plate heat exchangers

    NASA Technical Reports Server (NTRS)

    Rodriguez, Jose I.; Mills, Anthony F.

    1990-01-01

    An analysis of the single-blow transient testing technique for heat exchanger surfaces is made for perforated plate and similar discontinuous surfaces. The model assumes that there is no temperature variation across each plate, and allows for axial conduction in spacers: the resulting axial fluid temperature profile is discontinuous, rather than the usual continuous profile. Numerical solutions are obtained to the resulting set of coupled first-order differential equations for a step change in inlet fluid temperature. Results are presented in tabular form, which allow the heat transfer coefficients to be calculated from test data using the maximum slope technique.

  3. Single-Event Transient Testing of the Crane Aerospace and Electronics SMHF2812D Dual DC-DC Converter

    NASA Technical Reports Server (NTRS)

    Casey, Megan

    2015-01-01

    The purpose of this testing was to characterize the Crane Aerospace & Electronics (Crane) Interpoint SMHF2812D for single-event transient (SET) susceptibility. These data shall be used for flight lot evaluation, as well as qualification by similarity of the SMHF family of converters, all of which use the same active components.

  4. A single, mild, transient scrotal heat stress causes hypoxia and oxidative stress in mouse testes, which induces germ cell death.

    PubMed

    Paul, Catriona; Teng, Serena; Saunders, Philippa T K

    2009-05-01

    Spermatogenesis is a temperature-dependent process, and increases in scrotal temperature can disrupt its progression. We previously showed that heat stress causes DNA damage in germ cells, an increase in germ cell death (as seen on TUNEL staining), and subfertility. The present study evaluated the stress response in mouse testes following a single mild transient scrotal heat exposure (40 degrees C or 42 degrees C for 30 min). We investigated markers of three types of stress response, namely, hypoxia, oxidative stress, and apoptosis. Heat stress caused an increase in expression of hypoxia-inducible factor 1 alpha (Hif1a) mRNA expression and translocation of HIF1A protein to the germ cell nucleus, consistent with hypoxic stress. Increased expression of heme oxygenase 1 (Hmox1) and the antioxidant enzymes glutathione peroxidase 1 (GPX1) and glutathione S-transferase alpha (GSTA) was consistent with a robust oxidative stress response. Germ cell death was associated with an increase in expression of the effector caspase cleaved caspase 3 and a decrease in expression of the protein inhibitor of caspase-activated DNase (ICAD). Reduced expression of ICAD contributes to increased activity of caspase-activated DNase and is consistent with the increased rates of DNA fragmentation that have been detected previously using TUNEL staining. These studies confirmed that transient mild testicular hyperthermia results in temperature-dependent germ cell death and demonstrated that elevated temperature results in a complex stress response, including induction of genes associated with oxidative stress and hypoxia.

  5. Single-Event Transient Testing of Low Dropout PNP Series Linear Voltage Regulators

    NASA Technical Reports Server (NTRS)

    Adell, Philippe; Allen, Gregory

    2013-01-01

    As demand for high-speed, on-board, digital-processing integrated circuits on spacecraft increases (field-programmable gate arrays and digital signal processors in particular), the need for the next generation point-of-load (POL) regulator becomes a prominent design issue. Shrinking process nodes have resulted in core rails dropping to values close to 1.0 V, drastically reducing margin to standard switching converters or regulators that power digital ICs. The goal of this task is to perform SET characterization of several commercial POL converters, and provide a discussion of the impact of these results to state-of-the-art digital processing IC through laser and heavy ion testing

  6. Depth-discrete specific storage in fractured sedimentary rock using steady-state and transient single-hole hydraulic tests

    NASA Astrophysics Data System (ADS)

    Quinn, Patryk M.; Cherry, John A.; Parker, Beth L.

    2016-11-01

    A method is presented for obtaining depth-discrete values of specific storage (Ss) from single-hole hydraulic tests in fractured rock boreholes using straddle packers (1.5-17 m test intervals). Low flow constant head (CH) step tests analyzed using the Thiem method provide transmissivity (T) values free from non-Darcian error. Short-term, constant-rate pumping tests (0.5-2 h) analyzed using the Cooper-Jacob approximation of the Theis method provide S from the hydraulic diffusivity using the Darcian T value from the CH step test. This synergistic use of two types of hydraulic tests avoids the common source of error when pumping tests (injection or withdrawal) are conducted at higher flow rates and thereby induce non-Darcian flow resulting in the underestimation of T. Other errors, such as well bore storage and leakage, can also substantially influence S by causing a shift in the time axis of the Cooper-Jacob semi-log plot. In this approach, the Darcian T values from the CH step tests are used in the analysis of the transient pumping test data for calculating S throughout the pumping test using the Cooper-Jacob approximation to minimize all of the aforementioned errors, resulting in more representative S values. The effect of these non-idealities on the measured drawdown is illustrated using the Theis equation with the Darcian T and S values to calculate drawdown for comparison to measured data. The Ss values for tests in sandstone obtained from this approach are more consistent with confined aquifer conditions than values derived from the traditional Cooper-Jacob method, and are within the range of field and lab values presented from a compilation of literature values for fractured sandstone. (10-7-10-5 m-1) This method for obtaining Ss values from short-interval, straddle packer tests improves the estimation of both K and Ss and provides opportunity to study their spatial distribution in fractured rock.

  7. Columbia University flow instability experimental program: Volume 12. Single annulus transient test program data tables: Part 1

    SciTech Connect

    Coutts, D.A.

    1993-09-01

    The single annulus test program was designed to investigate the onset of flow instability in an annular geometry similar to the fuel assemblies used in the Savannah River Site production reactors. Data files were transmitted from Columbia University to Savannah River Site in a DOS compatible format. This report provides a hardcopy version of the electronic media data files.

  8. Single Event Transients in Low Voltage Dropout (LVDO) Voltage Regulators

    NASA Technical Reports Server (NTRS)

    LaBel, K.; Karsh, J.; Pursley, S.; Kleyner, I.; Katz, R.; Poivey, C.; Kim, H.; Seidleck, C.

    2006-01-01

    This viewgraph presentation reviews the use of Low Voltage Dropout (LVDO) Voltage Regulators in environments where heavy ion induced Single Event Transients are a concern to the designers.Included in the presentation are results of tests of voltage regulators.

  9. Transient Pressure Test Article (TPTA) Test

    NASA Technical Reports Server (NTRS)

    1987-01-01

    A forward segment is being lowered into the Transient Pressure Test Article (TPTA) test stand at the Marshall Space Flight Center (MSFC) east test area. The TPTA test stand, 14-feet wide, 27-feet long, and 33-feet high, was built in 1987 to provide data to verify the sealing capability of the redesign solid rocket motor (SRM) field and nozzle joints. The test facility applies pressure, temperature, and external loads to a short stack of solid rocket motor hardware. The simulated SRM ignition pressure and temperature transients are achieved by firing a small amount of specially configured solid propellant. The pressure transient is synchronized with external programmable dynamic loads that simulate lift off loads at the external tank attach points. Approximately one million pounds of dead weight on top of the test article simulates the weight of the other Shuttle elements.

  10. Transient Pressure Test Article (TPTA) Test Stand

    NASA Technical Reports Server (NTRS)

    1987-01-01

    A forward segment is being lowered into the Transient Pressure Test Article (TPTA) test stand at thw Marshall Space Flight Center (MSFC) east test area. The TPTA test stand, 14-feet wide, 27-feet long, and 33-feet high, was built in 1987 to provide data to verify the sealing capability of the redesign solid rocket motor (SRM) field and nozzle joints. The test facility applies pressure, temperature, and external loads to a short stack of solid rocket motor hardware. The simulated SRM ignition pressure and temperature transients are achieved by firing a small amount of specially configured solid propellant. The pressure transient is synchronized with external programmable dynamic loads that simulate lift off loads at the external tank attach points. Approximately one million pounds of dead weight on top of the test article simulates the weight of the other Shuttle elements.

  11. Transient Pressure Test Article test program

    NASA Technical Reports Server (NTRS)

    Vibbart, Charles M.

    1988-01-01

    The Transient Pressure Test Article test program being conducted at NASA-Marshall is described. The main goal of the TPTA test program is to provide data to verify the sealing capability of the redesigned SRM field joints, the nozzle-to-case joint, and the igniter joint. The TPTA test program can be used to demonstrate the assembly/disassembly and reusability of the redesigned joints along with the adequacy of assembly/disassembly tooling, procedures, and inspections.

  12. Transient Pressure Test Article (TPTA) Test Firing

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The Marshall Space Flight Center (MSFC) successfully test fired the third in a series of Transient Pressure Test Articles (TPTA) in its east test area. The test article was a short-stack solid rocket motor 52-feet long and 12-feet in diameter. The TPTA tests were designed to evaluate the effects of temperature, pressure and external loads encountered by the SRM, primarily during ignition transients. Instrumentation on the motor recorded approximately 1,000 charnels of data to verify the structural performance, thermal response, sealing capability of the redesign field, and case-to-nozzle joints. The TPTA test stand, 14-feet wide by 26-feet long by 33-feet high, was built in 1987. The TPTA series was a joint effort among Morton Thiokol, Inc., United Space Boosters, Inc., Wyle Laboratories, and MSFC. Wyle Laboratories conducted the tests for the MSFC, which manages the redesigned SRM program for NASA.

  13. Single-Event Transients in Voltage Regulators

    NASA Technical Reports Server (NTRS)

    Johnston, Allan H.; Miyahira, Tetsuo F.; Irom, F.; Laird, Jamie S.

    2006-01-01

    Single-event transients are investigated for two voltage regulator circuits that are widely used in space. A circuit-level model is developed that can be used to determine how transients are affected by different circuit application conditions. Internal protection circuits-which are affected by load as well as internal thermal effects-can also be triggered from heavy ions, causing dropouts or shutdown ranging from milliseconds to seconds. Although conventional output transients can be reduced by adding load capacitance, that approach is ineffective for dropouts from protection circuitry.

  14. Transient Pressure Test Article Test Program

    NASA Technical Reports Server (NTRS)

    Vibbart, Charles M.

    1989-01-01

    The Transient Pressure Test Article (TPTA) test program is being conducted at a new test facility located in the East Test Area at the National Aeronautics and Space Administration's (NASA's) Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This facility, along with the special test equipment (STE) required for facility support, was constructed specifically to test and verify the sealing capability of the Redesigned Solid Rocket Motor (RSRM) field, igniter, and nozzle joints. The test article consists of full scale RSRM hardware loaded with inert propellant and assembled in a short stack configuration. The TPTA is pressurized by igniting a propellant cartridge capable of inducing a pressure rise rate which stimulates the ignition transient that occurs during launch. Dynamic loads are applied during the pressure cycle to simulate external tank attach (ETA) strut loads present on the ETA ring. Sealing ability of the redesigned joints is evaluated under joint movement conditions produced by these combined loads since joint sealing ability depends on seal resilience velocity being greater than gap opening velocity. Also, maximum flight dynamic loads are applied to the test article which is either pressurized to 600 psia using gaseous nitrogen (GN2) or applied to the test article as the pressure decays inside the test article on the down cycle after the ignition transient cycle. This new test facility is examined with respect to its capabilities. In addition, both the topic of test effectiveness versus space vehicle flight performance and new aerospace test techniques, as well as a comparison between the old SRM design and the RSRM are presented.

  15. Current transients in single nanoparticle collision events.

    PubMed

    Xiao, Xiaoyin; Fan, Fu-Ren F; Zhou, Jiping; Bard, Allen J

    2008-12-10

    Electrochemical hydrazine oxidation and proton reduction occur at a significantly higher rate at Pt than at Au or C electrodes. Thus, the collision and adhesion of a Pt particle on a less active Au or C electrode leads to a large current amplification by electrocatalysis at single nanoparticles (NPs). At low particle concentrations, the collision of Pt NPs was characterized by current transients composed of individual current profiles that rapidly attained a steady state, signaling single NP collisions. The characteristic steady-state current was used to estimate the particle size. The fluctuation in collision frequency with time indicates that the collision of NPs at the detector electrodes occurs in a statistically random manner, with the average frequency a function of particle concentration and diffusion coefficient. A longer term current decay in single current transients, as opposed to the expected steady-state behavior, was more pronounced for proton reduction than for hydrazine oxidation, revealing microscopic details of the nature of the particle interaction with the detector electrode and the kinetics of electrocatalysis at single NPs. The study of single NP collisions allows one to screen particle size distributions and estimate NP concentrations and diffusion coefficients.

  16. Analysis and RHBD technique of single event transients in PLLs

    NASA Astrophysics Data System (ADS)

    Zhiwei, Han; Liang, Wang; Suge, Yue; Bing, Han; Shougang, Du

    2015-11-01

    Single-event transient susceptibility of phase-locked loops has been investigated. The charge pump is the most sensitive component of the PLL to SET, and it is hard to mitigate this effect at the transistor level. A test circuit was designed on a 65 nm process using a new system-level radiation-hardening-by-design technique. Heavy-ion testing was used to evaluate the radiation hardness. Analyses and discussion of the feasibility of this method are also presented.

  17. Single Event Transients in Linear Integrated Circuits

    NASA Technical Reports Server (NTRS)

    Buchner, Stephen; McMorrow, Dale

    2005-01-01

    On November 5, 2001, a processor reset occurred on board the Microwave Anisotropy Probe (MAP), a NASA mission to measure the anisotropy of the microwave radiation left over from the Big Bang. The reset caused the spacecraft to enter a safehold mode from which it took several days to recover. Were that to happen regularly, the entire mission would be compromised, so it was important to find the cause of the reset and, if possible, to mitigate it. NASA assembled a team of engineers that included experts in radiation effects to tackle the problem. The first clue was the observation that the processor reset occurred during a solar event characterized by large increases in the proton and heavy ion fluxes emitted by the sun. To the radiation effects engineers on the team, this strongly suggested that particle radiation might be the culprit, particularly when it was discovered that the reset circuit contained three voltage comparators (LM139). Previous testing revealed that large voltage transients, or glitches appeared at the output of the LM139 when it was exposed to a beam of heavy ions [NI96]. The function of the reset circuit was to monitor the supply voltage and to issue a reset command to the processor should the voltage fall below a reference of 2.5 V [PO02]. Eventually, the team of engineers concluded that ionizing particle radiation from the solar event produced a negative voltage transient on the output of one of the LM139s sufficiently large to reset the processor on MAP. Fortunately, as of the end of 2004, only two such resets have occurred. The reset on MAP was not the first malfunction on a spacecraft attributed to a transient. That occurred shortly after the launch of NASA s TOPEX/Poseidon satellite in 1992. It was suspected, and later confirmed, that an anomaly in the Earth Sensor was caused by a transient in an operational amplifier (OP-15) [KO93]. Over the next few years, problems on TDRS, CASSINI, [PR02] SOHO [HA99,HA01] and TERRA were also attributed

  18. Stability Test for Transient-Temperature Calculations

    NASA Technical Reports Server (NTRS)

    Campbell, W.

    1984-01-01

    Graphical test helps assure numerical stability of calculations of transient temperature or diffusion in composite medium. Rectangular grid forms basis of two-dimensional finite-difference model for heat conduction or other diffusion like phenomena. Model enables calculation of transient heat transfer among up to four different materials that meet at grid point.

  19. Transient Sub-Poissonian Distribution for Single-Mode Lasers

    NASA Technical Reports Server (NTRS)

    Zang, J. Y.; Gu, Q.; Tian, L. K.

    1996-01-01

    In this paper, the transient photon statistics for single-mode lasers is investigated by making use of the theory of quantum electrodynamics. By taking into account of the transitive time l,we obtain the master equation for Jaynes-Cummings model. The relation between the Mandel factor and the time is obtained by directly solving the master equation. The result shows that a transient phenomenon from the transient super-Poissonian distribution to the transient sub-Poissonian distribution occurs for single-mode lasers. In addition, the influences of the thermal light field and the cavity loss on the transient sub-Poissonian distribution are also studied.

  20. Analysis and Simulations of Space Radiation Induced Single Event Transients

    NASA Astrophysics Data System (ADS)

    Perez, Reinaldo

    2016-05-01

    Spacecraft electronics are affected by the space radiation environment. Among the different types of radiation effects that can affect spacecraft electronics is the single event transients. The space environment is responsible for many of the single event transients which can upset the performance of the spacecraft avionics hardware. In this paper we first explore the origins of single event transients, then explore the modeling of a single event transient in digital and analog circuit. The paper also addresses the concept of crosstalk that could develop among digital circuits in the present of a SET event. The paper ends with a brief discussion of SET hardening. The goal of the paper is to provide methodologies for assessing single event transients and their effects so that spacecraft avionics engineers can develop either hardware or software countermeasures in their designs.

  1. Future Transient Testing of Advanced Fuels

    SciTech Connect

    Jon Carmack

    2009-09-01

    The transient in-reactor fuels testing workshop was held on May 4–5, 2009 at Idaho National Laboratory. The purpose of this meeting was to provide a forum where technical experts in transient testing of nuclear fuels could meet directly with technical instrumentation experts and nuclear fuel modeling and simulation experts to discuss needed advancements in transient testing to support a basic understanding of nuclear fuel behavior under off-normal conditions. The workshop was attended by representatives from Commissariat à l'Énergie Atomique CEA, Japanese Atomic Energy Agency (JAEA), Department of Energy (DOE), AREVA, General Electric – Global Nuclear Fuels (GE-GNF), Westinghouse, Electric Power Research Institute (EPRI), universities, and several DOE national laboratories. Transient testing of fuels and materials generates information required for advanced fuels in future nuclear power plants. Future nuclear power plants will rely heavily on advanced computer modeling and simulation that describes fuel behavior under off-normal conditions. TREAT is an ideal facility for this testing because of its flexibility, proven operation and material condition. The opportunity exists to develop advanced instrumentation and data collection that can support modeling and simulation needs much better than was possible in the past. In order to take advantage of these opportunities, test programs must be carefully designed to yield basic information to support modeling before conducting integral performance tests. An early start of TREAT and operation at low power would provide significant dividends in training, development of instrumentation, and checkout of reactor systems. Early start of TREAT (2015) is needed to support the requirements of potential users of TREAT and include the testing of full length fuel irradiated in the FFTF reactor. The capabilities provided by TREAT are needed for the development of nuclear power and the following benefits will be realized by the

  2. Results from transient tests and spherical valve closure tests, Raccoon Mountain Pumped-Storage Plant

    SciTech Connect

    March, P.A.

    1984-09-01

    Tests were conducted at the Raccoon Mountain Pumped-Storage Plant to obtain data on hydraulic system characteristics during transient-state operation, to compare measured values for system pressures and surge levels with design values, to provide information for review of hydaulic transient computations, and to provide confirmation that the spherical valves are capable of shutting off plant flow under emergency conditions. The tests included single-unit load rejection, single-unit pump power loss, multi-unit emergency shutdown from generating, multi-unit emergency shutdown from pumping, and spherical valve closure.

  3. Sensitive, time-resolved, broadband spectroscopy of single transient processes

    NASA Astrophysics Data System (ADS)

    Fjodorow, Peter; Baev, Ivan; Hellmig, Ortwin; Sengstock, Klaus; Baev, Valery M.

    2015-09-01

    Intracavity absorption spectroscopy with a broadband Er3+-doped fiber laser is applied to time-resolved measurements of transient gain and absorption in electrically excited Xe and Kr plasmas. The achieved time resolution for broadband spectral recording of a single process is 25 µs. For pulsed-periodic processes, the time resolution is limited by the laser pulse duration, which is set here to 3 µs. This pulse duration also predefines the effective absorption path length, which amounts to 900 m. The presented technique can be applied to multicomponent analysis of single transient processes such as shock tube experiments, pulse detonation engines, or explosives.

  4. Transient well testing in two-phase geothermal reservoirs

    SciTech Connect

    Aydelotte, S.R.

    1980-03-01

    A study of well test analysis techniques in two-phase geothermal reservoirs has been conducted using a three-dimensional, two-phase, wellbore and reservoir simulation model. Well tests from Cerro Prieto and the Hawaiian Geothermal project have been history matched. Using these well tests as a base, the influence of reservoir permeability, porosity, thickness, and heat capacity, along with flow rate and fracturing were studied. Single and two-phase transient well test equations were used to analyze these tests with poor results due to rapidly changing fluid properties and inability to calculate the flowing steam saturation in the reservoir. The injection of cold water into the reservoir does give good data from which formation properties can be calculated.

  5. Method and device for measuring single-shot transient signals

    DOEpatents

    Yin, Yan

    2004-05-18

    Methods, apparatus, and systems, including computer program products, implementing and using techniques for measuring multi-channel single-shot transient signals. A signal acquisition unit receives one or more single-shot pulses from a multi-channel source. An optical-fiber recirculating loop reproduces the one or more received single-shot optical pulses to form a first multi-channel pulse train for circulation in the recirculating loop, and a second multi-channel pulse train for display on a display device. The optical-fiber recirculating loop also optically amplifies the first circulating pulse train to compensate for signal losses and performs optical multi-channel noise filtration.

  6. Transient analysis of the 1991 Hijiori Shallow Reservoir Circulation Test

    SciTech Connect

    Hyodo, M.; Shinohara, N.; Takasugi, S.; Wright, C.A.; Conant, R..

    1996-01-24

    Like any dynamic system, HDR reservoirs cannot be fully characterized by their steady-state behavior. Circulation tests analysis should be performed on both the steady-state response and the transient response of HDR systems. Transient analysis allows not only estimation of critical reservoir parameters and how these parameters change with operating conditions / history, but transient analysis also aids in evaluating the feasibility of various modes of HDR system operation (base load, load following, etc.). This paper details the transient analysis of NEDO's FY 1991 Shallow Reservoir Circulation Test at the Hijiori HDR site in Japan. Reservoir fluid storage is carefully bounded through the employment of two distinct methods for calculation of the fluid storage from the observed transient response. A brief discussion is also included of the distribution of reservoir fluid storage; the relationship between pressure, reservoir stress, and apparent reservoir capacitance; and appropriate circulation test design to facilitate transient analysis.

  7. Transient Molecular Transfer During Vacuum Testing

    NASA Technical Reports Server (NTRS)

    Perry, Radford L.

    2011-01-01

    A common question in contamination budgeting involves the loss of collected volatiles during ambient I&T activity under vacuum and the resultant cross-contamination from outgassing. (1) How much of the material collected under ambient conditions evaporates under vacuum? (2) Why do pristine surfaces sometimes show increased molecular contamination after vacuum bakeout? (3) How much of the collected molecular contamination is transient (i.e. migratory) and how much is permanent? Measuring the transient deposition may be accomplished using a thermally passive QCM

  8. Transient vibration test criteria for spacecraft hardware. [galileo spacecraft

    NASA Technical Reports Server (NTRS)

    Kern, D. L.; Hayes, C. D.

    1984-01-01

    Transient vibration test criteria, developed for spacecraft hardware, provide a test rationale to verify the capability of the hardware to withstand the low and mid frequency transient vibration environments induced by launch vehicle events. A test method, consisting of a series of discrete frequency, limited cycle, modulated sine wave pulses, was developed to avoid the slow swept sine drawbacks, yet provide a repeatable test that would excite all frequencies. The shape of the waveform is that of the classic response of the mass of a one degree of freedom system when it is base-excited by an exponentially decayed sine wave transient. Criteria were developed to define pulse amplitudes, shapes, and center frequencies from spacecraft loads analyses. Test tolerance criteria were also developed and specified. The transient vibration test criteria were implemented on spacecraft flight hardware and provided a more realistic test simulation (i.e., less conservative) for qualification of spacecraft hardware without risk of undertest.

  9. Ultrafast transient absorption studies of single metal and semiconductor nanowires

    NASA Astrophysics Data System (ADS)

    Hartland, Gregory V.; Carey, Christopher R.; Staleva, Hristina

    2010-02-01

    Single particle transient absorption experiments have been used to study metallic and semiconducting nanowires. For the metal wires the major result is the observation of modulations in the transient absorption traces due to coherently excited breathing modes. The vibrational periods depend on the dimensions of the nanowire, and the decay times are sensitive to the environment. The nanowires in our experiments are spin coated from a polymer solution onto a glass substrate, and experience a range of different environments. This causes large variations in the quality factor of the breathing mode for different wires. Semiconducting nanowires of CdTe and CdSe were also examined. The CdTe wires show fast picosecond time scale dynamics, which are assigned to charge carrier trapping at surface states of the wires. In contrast, CdSe nanowires show no dynamics on the time scale of our measurements. For the CdTe nanowires the charge carrier trapping times vary from wire-to-wire, and also vary with position in a single wire. This is attributed to differences in surface chemistry. Overall these experiments illustrate the important of single particle techniques for studying nanomaterials, especially for elucidating how differences in local environment and structure affect dynamics.

  10. Multi-axis transient vibration testing of space objects: Test philosophy, test facility, and control strategy

    NASA Technical Reports Server (NTRS)

    Lachenmayr, Georg

    1992-01-01

    IABG has been using various servohydraulic test facilities for many years for the reproduction of service loads and environmental loads on all kinds of test objects. For more than 15 years, a multi-axis vibration test facility has been under service, originally designed for earthquake simulation but being upgraded to the demands of space testing. First tests with the DFS/STM showed good reproduction accuracy and demonstrated the feasibility of transient vibration testing of space objects on a multi-axis hydraulic shaker. An approach to structural qualification is possible by using this test philosophy. It will be outlined and its obvious advantages over the state-of-the-art single-axis test will be demonstrated by example results. The new test technique has some special requirements to the test facility exceeding those of earthquake testing. Most important is the high reproduction accuracy demanded for a sophisticated control system. The state-of-the-art approach of analog closed-loop control circuits for each actuator combined with a static decoupling network and an off-line iterative waveform control is not able to meet all the demands. Therefore, the future over-all control system is implemented as hierarchical full digital closed-loop system on a highly parallel transputer network. The innermost layer is the digital actuator controller, the second one is the MDOF-control of the table movement. The outermost layer would be the off-line iterative waveform control, which is dedicated only to deal with the interaction of test table and test object or non-linear effects. The outline of the system will be presented.

  11. Space Shuttle solid rocket motor testing for return to flight - Transient Pressure Test Article test program

    NASA Technical Reports Server (NTRS)

    Vibbart, Charles M.

    1988-01-01

    The Transient Pressure Test Article (TPTA) test program, which is being conducted at a new facility at NASA-Marshall, is described. The facility is designed to test and verify the sealing capability of the redesigned solid rocket motor's (RSRM) field, igniter, and nozzle joints. The test article consists of full-scale RSRM hardware loaded with inert propellant and assembled in a short stack configuration. The test facility is described as well as test implementation, test effectiveness, and test results.

  12. Alternatives Analysis for the Resumption of Transient Testing Program

    SciTech Connect

    Lee Nelson

    2013-11-01

    An alternatives analysis was performed for resumption of transient testing. The analysis considered eleven alternatives – including both US international facilities. A screening process was used to identify two viable alternatives from the original eleven. In addition, the alternatives analysis includes a no action alternative as required by the National Environmental Policy Act (NEPA). The alternatives considered in this analysis included: 1. Restart the Transient Reactor Test Facility (TREAT) 2. Modify the Annular Core Research Reactor (ACRR) which includes construction of a new hot cell and installation of a new hodoscope. 3. No Action

  13. Plasma-Catalysis During Temperature Transient Testing

    SciTech Connect

    Hoard, John

    2001-08-05

    A combination of catalysts is used together with nonthermal plasma in simulated diesel exhaust, while the gas temperature is varied. The catalysts both store and convert pollutants. As a result, pollutant concentrations during temperature ramps are different than those at steady state conditions. The data are presented for plasma followed by BaY, alumina, and Pt catalysts in simulated exhaust. When temperature ramps from high to low, apparent NOx conversion is quite high. However, when temperature is ramped from low to high, lower apparent conversions are seen. In a typical test cycle, average NOx conversion between 100 and 400 C is 60%. Peak conversion during the down ramp is over 90%, and minimum conversion during the up ramp is 30%. The composition of the effluent gas also varies during the temperature cycle. Intermediates such as methyl nitrate and hydrogen cyanide are not present following the combination of catalysts.

  14. Transient fluctuations in cognitive functioning in schizophrenia based on single-case study methods.

    PubMed

    Tracy, J I; Oesterling, R; Josiassen, R C

    1995-10-01

    The stability of cognitive performance in four schizophrenia patients was examined over a short time period. A cognitive battery highly sensitive to organismic state (the Repeatable Cognitive-Perceptual-Motor Battery, RCPM) was utilized. Single-case statistical methods tested for within-individual change across five assessments at two week intervals. All four subjects showed statistically significant post-baseline variation in a global measure of impairment (average impairment rating score) and in at least 50% of the individual tests having adequate test-retest reliability. Data are interpreted as providing suggestive evidence of transient fluctuations in performance within a stable window of impaired cognitive functioning. These fluctuations appear substantial enough to influence both research and clinical outcomes. The benefits of the single-case methodology employed are discussed. The data suggest that significant transient fluctuations in cognitive performance can be observed in schizophrenia in domains purported to represent vulnerability markers of the disorder. The importance of accounting for these transient fluctuations in the attempt to identify enduring, trait-like characteristics of cognitive functioning in schizophrenia is discussed.

  15. Investigations on heavy ion induced Single-Event Transients (SETs) in highly-scaled FinFETs

    NASA Astrophysics Data System (ADS)

    Gaillardin, M.; Raine, M.; Paillet, P.; Adell, P. C.; Girard, S.; Duhamel, O.; Andrieu, F.; Barraud, S.; Faynot, O.

    2015-12-01

    We investigate Single-Event Transients (SET) in different designs of multiple-gate devices made of FinFETs with various geometries. Heavy ion experimental results are explained by using a thorough charge collection analysis of fast transients measured on dedicated test structures. Multi-level simulations are performed to get new insights into the charge collection mechanisms in multiple-gate devices. Implications for multiple-gate device design hardening are finally discussed.

  16. 40 CFR 86.1333 - Transient test cycle generation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... heavy-duty transient engine cycles for Otto-cycle and diesel engines are listed in appendix I((f) (1...) in these listings. (1) To unnormalize rpm, use the following equations: (i) For diesel engines... (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Exhaust Test Procedures...

  17. Intelligent transient transitions detection of LRE test bed

    NASA Astrophysics Data System (ADS)

    Zhu, Fengyu; Shen, Zhengguang; Wang, Qi

    2013-01-01

    Health Monitoring Systems is an implementation of monitoring strategies for complex systems whereby avoiding catastrophic failure, extending life and leading to improved asset management. A Health Monitoring Systems generally encompasses intelligence at many levels and sub-systems including sensors, actuators, devices, etc. In this paper, a smart sensor is studied, which is use to detect transient transitions of liquid-propellant rocket engines test bed. In consideration of dramatic changes of variable condition, wavelet decomposition is used to work real time in areas. Contrast to traditional Fourier transform method, the major advantage of adding wavelet analysis is the ability to detect transient transitions as well as obtaining the frequency content using a much smaller data set. Historically, transient transitions were only detected by offline analysis of the data. The methods proposed in this paper provide an opportunity to detect transient transitions automatically as well as many additional data anomalies, and provide improved data-correction and sensor health diagnostic abilities. The developed algorithms have been tested on actual rocket test data.

  18. Parametric Thermal Models of the Transient Reactor Test Facility (TREAT)

    SciTech Connect

    Bradley K. Heath

    2014-03-01

    This work supports the restart of transient testing in the United States using the Department of Energy’s Transient Reactor Test Facility at the Idaho National Laboratory. It also supports the Global Threat Reduction Initiative by reducing proliferation risk of high enriched uranium fuel. The work involves the creation of a nuclear fuel assembly model using the fuel performance code known as BISON. The model simulates the thermal behavior of a nuclear fuel assembly during steady state and transient operational modes. Additional models of the same geometry but differing material properties are created to perform parametric studies. The results show that fuel and cladding thermal conductivity have the greatest effect on fuel temperature under the steady state operational mode. Fuel density and fuel specific heat have the greatest effect for transient operational model. When considering a new fuel type it is recommended to use materials that decrease the specific heat of the fuel and the thermal conductivity of the fuel’s cladding in order to deal with higher density fuels that accompany the LEU conversion process. Data on the latest operating conditions of TREAT need to be attained in order to validate BISON’s results. BISON’s models for TREAT (material models, boundary convection models) are modest and need additional work to ensure accuracy and confidence in results.

  19. Pressure transient testing at Cerro Prieto Geothermal Field

    SciTech Connect

    Rivera, J.R.; Samaniego, F.V.; Schroeder, R.C.

    1980-01-01

    Because of the inherent problems in applying pressure build-up tests to wells producing two-phase fluids, it was decided to use variable flow tests of short duration known as two-rates tests. In these tests of variation in the well flow rates can be used to intepret the transient pressure response in order to determine reservoir parameters such as permeability, well-bore damage and mean reservoir pressure in the well drainage area. Some examples will illustrate the application of this technique. 11 refs.

  20. SINGLE HEATER TEST FINAL REPORT

    SciTech Connect

    J.B. Cho

    1999-05-01

    The Single Heater Test is the first of the in-situ thermal tests conducted by the U.S. Department of Energy as part of its program of characterizing Yucca Mountain in Nevada as the potential site for a proposed deep geologic repository for the disposal of spent nuclear fuel and high-level nuclear waste. The Site Characterization Plan (DOE 1988) contained an extensive plan of in-situ thermal tests aimed at understanding specific aspects of the response of the local rock-mass around the potential repository to the heat from the radioactive decay of the emplaced waste. With the refocusing of the Site Characterization Plan by the ''Civilian Radioactive Waste Management Program Plan'' (DOE 1994), a consolidated thermal testing program emerged by 1995 as documented in the reports ''In-Situ Thermal Testing Program Strategy'' (DOE 1995) and ''Updated In-Situ Thermal Testing Program Strategy'' (CRWMS M&O 1997a). The concept of the Single Heater Test took shape in the summer of 1995 and detailed planning and design of the test started with the beginning fiscal year 1996. The overall objective of the Single Heater Test was to gain an understanding of the coupled thermal, mechanical, hydrological, and chemical processes that are anticipated to occur in the local rock-mass in the potential repository as a result of heat from radioactive decay of the emplaced waste. This included making a priori predictions of the test results using existing models and subsequently refining or modifying the models, on the basis of comparative and interpretive analyses of the measurements and predictions. A second, no less important, objective was to try out, in a full-scale field setting, the various instruments and equipment to be employed in the future on a much larger, more complex, thermal test of longer duration, such as the Drift Scale Test. This ''shake down'' or trial aspect of the Single Heater Test applied not just to the hardware, but also to the teamwork and cooperation between

  1. Extending Theis' solution: Using transient pumping tests to estimate parameters of aquifer heterogeneity

    NASA Astrophysics Data System (ADS)

    Zech, Alraune; Müller, Sebastian; Mai, Juliane; Heße, Falk; Attinger, Sabine

    2016-08-01

    A framework for interpreting transient pumping tests in heterogeneous transmissivity fields is developed to infer the overall geostatistical parameters of the medium without reconstructing the specific heterogeneous structure point wise. The methodology of Radial Coarse Graining is applied to deduce an effective radial description of multi-Gaussian transmissivity. It was used to derive an Effective Well Flow Solution for transient flow conditions including not only the storativity, but also the geometric mean, the variance, and the correlation length of log-transmissivity. This solution is shown to be appropriate to characterize the pumping test drawdown behavior in heterogeneous transmissivity fields making use of ensembles of simulated pumping tests with multiple combinations of statistical parameters. Based on the Effective Well Flow Solution, a method is developed for inferring heterogeneity parameters from transient pumping test drawdown data by inverse estimation. Thereby, the impact of statistical parameters on the drawdown is analyzed, allowing to determine the dependence of reliability of parameter estimates on location and number of measurements. It is shown, that the number of measurements can be reduced compared to steady state pumping tests. Finally, a sampling strategy for single aquifer analysis is developed, which allows to estimate the statistical parameters, in particular variance and correlation length for individual heterogeneous transmissivity fields making use of transient pumping test measurements at multiple locations.

  2. Large transient fault current test of an electrical roll ring

    NASA Technical Reports Server (NTRS)

    Yenni, Edward J.; Birchenough, Arthur G.

    1992-01-01

    The space station uses precision rotary gimbals to provide for sun tracking of its photoelectric arrays. Electrical power, command signals and data are transferred across the gimbals by roll rings. Roll rings have been shown to be capable of highly efficient electrical transmission and long life, through tests conducted at the NASA Lewis Research Center and Honeywell's Satellite and Space Systems Division in Phoenix, AZ. Large potential fault currents inherent to the power system's DC distribution architecture, have brought about the need to evaluate the effects of large transient fault currents on roll rings. A test recently conducted at Lewis subjected a roll ring to a simulated worst case space station electrical fault. The system model used to obtain the fault profile is described, along with details of the reduced order circuit that was used to simulate the fault. Test results comparing roll ring performance before and after the fault are also presented.

  3. Transient suppression of MLH1 allows effective single-nucleotide substitution by single-stranded DNA oligonucleotides.

    PubMed

    Dekker, Marleen; de Vries, Sandra; Aarts, Marieke; Dekker, Robert; Brouwers, Conny; Wiebenga, Oliver; de Wind, Niels; Cantelli, Erika; Tonelli, Roberto; Te Riele, Hein

    2011-10-01

    Short synthetic single-stranded oligodeoxyribonucleotides (ssODNs) can be used to introduce subtle modifications into the genome of mouse embryonic stem cells (ESCs). We have previously shown that effective application of ssODN-mediated gene targeting in ESC requires (transient) suppression of DNA mismatch repair (MMR). However, whereas transient down-regulation of the mismatch recognition protein MSH2 allowed substitution of 3 or 4 nucleotides, 1 or 2 nucleotide substitutions were still suppressed. We now demonstrate that single- or dinucleotide substitution can effectively be achieved by transient down-regulation of the downstream MMR protein MLH1. By exploiting highly specific real-time PCR, we demonstrate the feasibility of substituting a single basepair in a non-selectable gene. However, disabling the MMR machinery may lead to inadvertent mutations. To obtain insight into the mutation rate associated with transient MMR suppression, we have compared the impact of transient and constitutive MMR deficiency on the repair of frameshift intermediates at mono- and dinucleotide repeats. Repair at these repeats relied on the substrate specificity and functional redundancy of the MSH2/MSH6 and MSH2/MSH3 MMR complexes. MLH1 knockdown increased the level of spontaneous mutagenesis, but modified ESCs remained germ line competent. Thus, transient MLH1 suppression provides a valuable extension of the MSH2 knockdown strategy, allowing rapid generation of mice carrying single basepair alterations in their genome.

  4. STEADY STATE MODELING OF THE MINIMUM CRITICAL CORE OF THE TRANSIENT REACTOR TEST FACILITY

    SciTech Connect

    Anthony L. Alberti; Todd S. Palmer; Javier Ortensi; Mark D. DeHart

    2016-05-01

    With the advent of next generation reactor systems and new fuel designs, the U.S. Department of Energy (DOE) has identified the need for the resumption of transient testing of nuclear fuels. The DOE has decided that the Transient Reactor Test Facility (TREAT) at Idaho National Laboratory (INL) is best suited for future testing. TREAT is a thermal neutron spectrum, air-cooled, nuclear test facility that is designed to test nuclear fuels in transient scenarios. These specific scenarios range from simple temperature transients to full fuel melt accidents. DOE has expressed a desire to develop a simulation capability that will accurately model the experiments before they are irradiated at the facility. It is the aim for this capability to have an emphasis on effective and safe operation while minimizing experimental time and cost. The multi physics platform MOOSE has been selected as the framework for this project. The goals for this work are to identify the fundamental neutronics properties of TREAT and to develop an accurate steady state model for future multiphysics transient simulations. In order to minimize computational cost, the effect of spatial homogenization and angular discretization are investigated. It was found that significant anisotropy is present in TREAT assemblies and to capture this effect, explicit modeling of cooling channels and inter-element gaps is necessary. For this modeling scheme, single element calculations at 293 K gave power distributions with a root mean square difference of 0.076% from those of reference SERPENT calculations. The minimum critical core configuration with identical gap and channel treatment at 293 K resulted in a root mean square, total core, radial power distribution 2.423% different than those of reference SERPENT solutions.

  5. Modeling transient streaming potentials in falling-head permeameter tests.

    PubMed

    Malama, Bwalya; Revil, André

    2014-01-01

    We present transient streaming potential data collected during falling-head permeameter tests performed on samples of two sands with different physical and chemical properties. The objective of the work is to estimate hydraulic conductivity (K) and the electrokinetic coupling coefficient (Cl ) of the sand samples. A semi-empirical model based on the falling-head permeameter flow model and electrokinetic coupling is used to analyze the streaming potential data and to estimate K and Cl . The values of K estimated from head data are used to validate the streaming potential method. Estimates of K from streaming potential data closely match those obtained from the associated head data, with less than 10% deviation. The electrokinetic coupling coefficient was estimated from streaming potential vs. (1) time and (2) head data for both sands. The results indicate that, within limits of experimental error, the values of Cl estimated by the two methods are essentially the same. The results of this work demonstrate that a temporal record of the streaming potential response in falling-head permeameter tests can be used to estimate both K and Cl . They further indicate the potential for using transient streaming potential data as a proxy for hydraulic head in hydrogeology applications.

  6. Tidal volume single-breath washin of SF6 and CH4 in transient microgravity

    NASA Technical Reports Server (NTRS)

    Dutrieue, Brigitte; Paiva, Manuel; Verbanck, Sylvia; Le Gouic, Marine; Darquenne, Chantal; Prisk, G. Kim

    2003-01-01

    We performed tidal volume single-breath washins (SBW) by using tracers of different diffusivity and varied the time spent in microgravity (microG) before the start of the tests to look for time-dependent effects. SF(6) and CH(4) phase III slopes decreased by 35 and 26%, respectively, in microG compared with 1 G (P < 0.05), and the slope difference between gases disappeared. There was no effect of time in microG, suggesting that neither the hypergravity period preceding microG nor the time spent in microG affected gas mixing at volumes near functional residual capacity. In previous studies using SF(6) and He (Lauzon A-M, Prisk GK, Elliott AR, Verbanck S, Paiva M, and West JB. J Appl Physiol 82: 859-865, 1997), the vital capacity SBW showed an increase in slope difference between gases in transient microG, the opposite of the decrease in sustained microG. In contrast, tidal volume SBW showed a decrease in slope difference in both microG conditions. Because it is only the behavior of the more diffusive gas that differed between maneuvers and microG conditions, we speculate that, in the previous vital capacity SBW, the hypergravity period preceding the test in transient microG provoked conformational changes at low lung volumes near the acinar entrance.

  7. Transient Analysis Used to Study Thermal Radiation Effects in Single and Composite Semitransparent Layers

    NASA Technical Reports Server (NTRS)

    1996-01-01

    In a continuing in-house program at the NASA Lewis Research Center, analytical and numerical methods are being developed to apply radiative analysis to predict transient temperature distributions and heat flows in partially transmitting materials. Results have been obtained for a single plane layer, and a transient analysis is being developed for a two-layer composite where each layer has a different refractive index. Because the ceramic refractive indices are larger than one, internal reflections are produced at the surfaces and at the internal interface. Reflections tend to distribute energy within a layer, and this affects the transient temperature distributions.

  8. Image analysis of single event transient effects on charge coupled devices irradiated by protons

    NASA Astrophysics Data System (ADS)

    Wang, Zujun; Xue, Yuanyuan; Liu, Jing; He, Baoping; Yao, Zhibin; Ma, Wuying

    2016-10-01

    The experiments of single event transient (SET) effects on charge coupled devices (CCDs) irradiated by protons are presented. The radiation experiments have been carried out at the accelerator protons with the energy of 200 MeV and 60 MeV.The incident angles of the protons are at 30°and 90° to the plane of the CCDs to obtain the images induced by the perpendicularity and incline incident angles. The experimental results show that the typical characteristics of the SET effects on a CCD induced by protons are the generation of a large number of dark signal spikes (hot pixels) which are randomly distributed in the "pepper" images. The characteristics of SET effects are investigated by observing the same imaging area at different time during proton radiation to verify the transient effects. The experiment results also show that the number of dark signal spikes increases with increasing integration time during proton radiation. The CCDs were tested at on-line and off-line to distinguish the radiation damage induced by the SET effects or DD effects. The mechanisms of the dark signal spike generation induced by the SET effects and the DD effects are demonstrated respectively.

  9. Single Event Transients in Voltage Regulators for FPGA Power Supply Applications

    NASA Technical Reports Server (NTRS)

    Poivey, Christian; Sanders, Anthony; Kim, Hak; Phan, Anthony; Forney, Jim; LaBel, Kenneth A.; Karsh, Jeremy; Pursley, Scott; Kleyner, Igor; Katz, Richard

    2006-01-01

    As with other bipolar analog devices, voltage regulators are known to be sensitive to single event transients (SET). In typical applications, large output capacitors are used to provide noise immunity. Therefore, since SET amplitude and duration are generally small, they are often of secondary importance due to this capacitance filtering. In low voltage applications, however, even small SET are a concern. Over-voltages may cause destructive conditions. Under-voltages may cause functional interrupts and may also trigger electrical latchup conditions. In addition, internal protection circuits which are affected by load as well as internal thermal effects can also be triggered from heavy ions, causing dropouts or shutdown ranging from milliseconds to seconds. In the case of FPGA power supplies applications, SETS are critical. For example, in the case of Actel FPGA RTAX family, core power supply voltage is 1.5V. Manufacturer specifies an absolute maximum rating of 1.6V and recommended operating conditions between 1.425V and 1.575V. Therefore, according to the manufacturer, any transient of amplitude greater than 75 mV can disrupt normal circuit functions, and overvoltages greater than 100 mV may damage the FPGA. We tested five low dropout voltage regulators for SET sensitivity under a large range of circuit application conditions.

  10. Transient productivity index for numerical well test simulations

    SciTech Connect

    Blanc, G.; Ding, D.Y.; Ene, A.

    1997-08-01

    The most difficult aspect of numerical simulation of well tests is the treatment of the Bottom Hole Flowing (BHF) Pressure. In full field simulations, this pressure is derived from the Well-block Pressure (WBP) using a numerical productivity index which accounts for the grid size and permeability, and for the well completion. This productivity index is calculated assuming a pseudo-steady state flow regime in the vicinity of the well and is therefore constant during the well production period. Such a pseudo-steady state assumption is no longer valid for the early time of a well test simulation as long as the pressure perturbation has not reached several grid-blocks around the well. This paper offers two different solutions to this problem: (1) The first one is based on the derivation of a Numerical Transient Productivity Index (NTPI) to be applied to Cartesian grids; (2) The second one is based on the use of a Corrected Transmissibility and Accumulation Term (CTAT) in the flow equation. The representation of the pressure behavior given by both solutions is far more accurate than the conventional one as shown by several validation examples which are presented in the following pages.

  11. Barometric pressure transient testing applications at the Nevada Test Site: formation permeability analysis. Final report

    SciTech Connect

    Hanson, J.M.

    1984-12-01

    The report evaluates previous investigations of the gas permeability of the rock surrounding emplacement holes at the Nevada Test Site. The discussion sets the framework from which the present uncertainty in gas permeability can be overcome. The usefulness of the barometric pressure testing method has been established. Flow models were used to evaluate barometric pressure transients taken at NTS holes U2fe, U19ac and U20ai. 31 refs., 103 figs., 18 tabs. (ACR)

  12. Comment on "Depth-discrete specific storage in fractured sedimentary rock using steady-state and transient single-hole hydraulic tests" by Patryk M. Quinn, John A. Cherry, Beth L. Parker, J. Hydrol. 542 (2016) 756-771

    NASA Astrophysics Data System (ADS)

    Çimen, Mesut

    2017-03-01

    Quinn et al. (2016) presented a method to estimate storativity (S) of fractured sedimentary rock from straddle packer tests after transmissivity (T) of aquifer was determined from low-flow constant-head (CH) step tests. Constant-rate pumping tests were carried out to determine S by using the Cooper and Jacob (1946) approximation. Estimating the aquifer parameters depends on a matching of observation data to theoretical response which is mathematically obtained from a physical model. The results of both constant rate injection and withdrawal tests in the borehole C6zone17 cannot show this simulation. This comment proposes a reasonable procedure to estimate storativity.

  13. Analytical modeling for transient probe response in eddy current testing

    NASA Astrophysics Data System (ADS)

    Desjardins, Daniel

    Analytical models that describe the electromagnetic field interactions arising between field generating and sensing coils in close proximity to conducting structures can be used to enhance analysis and information extracted from signals obtained using electromagnetic non-destructive evaluation technologies. A novel strategy, which enables the derivation of exact solutions describing all electromagnetic interactions arising in inductively coupled circuits due to a voltage excitation, is developed in this work. Differential circuit equations are formulated in terms of an arbitrary voltage excitation and of the magnetic fields arising in inductive systems, using Faraday's law and convolution, and solved using the Fourier transform. The approach is valid for systems containing any number of driving and receiving coils, and include nearby conducting and ferromagnetic structures. In particular, the solutions account for feedback between a ferromagnetic conducting test piece and the driving and sensing coils, providing correct voltage response of the coils. Also arising from the theory are analytical expressions for complex inductances in a circuit, which account for real (inductive) and imaginary (loss) elements associated with conducting and ferromagnetic structures. A novel model-based method for simultaneous characterization of material parameters, which includes magnetic permeability, electrical conductivity, wall thickness and liftoff, is subsequently developed from the forward solutions. Furthermore, arbitrary excitation waveforms, such as a sinusoid or a square wave, for applications in conventional and transient eddy current, respectively, may be considered. Experimental results, obtained for a square wave excitation, are found to be in excellent agreement with the analytical predictions.

  14. Revisiting single photon avalanche diode current-voltage modeling and transient characteristics

    SciTech Connect

    Javitt, M.; Savuskan, V. Merhav, T.; Nemirovsky, Y.

    2014-05-28

    A model for the current-voltage and transient behavior of Single Photon Avalanche Diodes (SPADs) based on device physics is presented. The results of the model are compared to actual measurements and a reasonable fit is seen. Additionally, the model provides a useful tool for designing quenching circuitry and determining optimal operation conditions of the SPAD.

  15. Dissolution chemistry and biocompatibility of single-crystalline silicon nanomembranes and associated materials for transient electronics.

    PubMed

    Hwang, Suk-Won; Park, Gayoung; Edwards, Chris; Corbin, Elise A; Kang, Seung-Kyun; Cheng, Huanyu; Song, Jun-Kyul; Kim, Jae-Hwan; Yu, Sooyoun; Ng, Joanne; Lee, Jung Eun; Kim, Jiyoung; Yee, Cassian; Bhaduri, Basanta; Su, Yewang; Omennetto, Fiorenzo G; Huang, Yonggang; Bashir, Rashid; Goddard, Lynford; Popescu, Gabriel; Lee, Kyung-Mi; Rogers, John A

    2014-06-24

    Single-crystalline silicon nanomembranes (Si NMs) represent a critically important class of material for high-performance forms of electronics that are capable of complete, controlled dissolution when immersed in water and/or biofluids, sometimes referred to as a type of "transient" electronics. The results reported here include the kinetics of hydrolysis of Si NMs in biofluids and various aqueous solutions through a range of relevant pH values, ionic concentrations and temperatures, and dependence on dopant types and concentrations. In vitro and in vivo investigations of Si NMs and other transient electronic materials demonstrate biocompatibility and bioresorption, thereby suggesting potential for envisioned applications in active, biodegradable electronic implants.

  16. A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A.

    PubMed

    Montoliu, Carmina; Piedrafita, Blanca; Serra, Miguel A; del Olmo, Juan A; Rodrigo, José M; Felipo, Vicente

    2007-01-01

    Hepatic encephalopathy in patients with liver disease is associated with poor prognosis. This could be due to the induction by the transient episode of hepatic encephalopathy of long-lasting alterations making patients more susceptible. We show that a single transient episode of hyperammonemia induces long-lasting alterations in signal transduction. The content of the regulatory subunit of the protein kinase dependent on cAMP (PKA-RI) is increased in erythrocytes from cirrhotic patients. This increase is reproduced in rats with portacaval anastomosis and in rats with hyperammonemia without liver failure, suggesting that hyperammonemia is responsible for increased PKA-RI in patients. We analyzed whether there is a correlation between ammonia levels and PKA-RI content in patients. All cirrhotic patients had increased content of PKA-RI. Some of them showed normal ammonia levels but had suffered previous hyperammonemia episodes. This suggested that a single transient episode of hyperammonemia could induce the long-lasting increase in PKA-RI. To assess this, we injected normal rats with ammonia and blood was taken at different times. Ammonia returned to basal levels at 2 h. However, PKA-RI was significantly increased in blood cells from rats injected with ammonia 3 wk after injection. In conclusion, it is shown that a single transient episode of hyperammonemia induces long-lasting alterations in signal transduction both in blood and brain. These alterations may contribute to the poor prognosis of patients suffering hepatic encephalopathy.

  17. Label-Free Imaging of Dynamic and Transient Calcium Signaling in Single Cells.

    PubMed

    Lu, Jin; Li, Jinghong

    2015-11-09

    Cell signaling consists of diverse events that occur at various temporal and spatial scales, ranging from milliseconds to hours and from single biomolecules to cell populations. The pathway complexities require the development of new techniques that detect the overall signaling activities and are not limited to quantifying a single event. A plasmonic-based electrochemical impedance microscope (P-EIM) that can provide such data with excellent temporal and spatial resolution and does not require the addition of any labels for detection has now been developed. The highly dynamic and transient calcium signaling activities at the early stage of G-protein-coupled receptor (GPCR) stimulation were thus studied. It could be shown that a subpopulation of cells is more responsive towards agonist stimulation, and the heterogeneity of the local distributions and the transient activities of the ion channels during agonist-activated calcium flux in single HeLa cells were investigated.

  18. 40 CFR 1048.510 - What transient duty cycles apply for laboratory testing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What transient duty cycles apply for... Procedures § 1048.510 What transient duty cycles apply for laboratory testing? (a) Starting with the 2007 model year, measure emissions by testing the engine on a dynamometer with the duty cycle described...

  19. 40 CFR 1048.510 - What transient duty cycles apply for laboratory testing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What transient duty cycles apply for... Procedures § 1048.510 What transient duty cycles apply for laboratory testing? (a) Starting with the 2007 model year, measure emissions by testing the engine on a dynamometer with the duty cycle described...

  20. 40 CFR 1048.510 - What transient duty cycles apply for laboratory testing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What transient duty cycles apply for... Procedures § 1048.510 What transient duty cycles apply for laboratory testing? (a) Starting with the 2007 model year, measure emissions by testing the engine on a dynamometer with the duty cycle described...

  1. 40 CFR Appendix E to Subpart S of... - Transient Test Driving Cycle

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Transient Test Driving Cycle E Appendix... Driving Cycle (I) Driver's trace. All excursions in the transient driving cycle shall be evaluated by the... determine a valid test. (II) Driving cycle. The following table shows the time speed relationship for...

  2. 40 CFR Appendix E to Subpart S of... - Transient Test Driving Cycle

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 2 2011-07-01 2011-07-01 false Transient Test Driving Cycle E Appendix... Driving Cycle (I) Driver's trace. All excursions in the transient driving cycle shall be evaluated by the... determine a valid test. (II) Driving cycle. The following table shows the time speed relationship for...

  3. Preliminary Analysis of the Transient Reactor Test Facility (TREAT) with PROTEUS

    SciTech Connect

    Connaway, H. M.; Lee, C. H.

    2015-11-30

    The neutron transport code PROTEUS has been used to perform preliminary simulations of the Transient Reactor Test Facility (TREAT). TREAT is an experimental reactor designed for the testing of nuclear fuels and other materials under transient conditions. It operated from 1959 to 1994, when it was placed on non-operational standby. The restart of TREAT to support the U.S. Department of Energy’s resumption of transient testing is currently underway. Both single assembly and assembly-homogenized full core models have been evaluated. Simulations were performed using a historic set of WIMS-ANL-generated cross-sections as well as a new set of Serpent-generated cross-sections. To support this work, further analyses were also performed using additional codes in order to investigate particular aspects of TREAT modeling. DIF3D and the Monte-Carlo codes MCNP and Serpent were utilized in these studies. MCNP and Serpent were used to evaluate the effect of geometry homogenization on the simulation results and to support code-to-code comparisons. New meshes for the PROTEUS simulations were created using the CUBIT toolkit, with additional meshes generated via conversion of selected DIF3D models to support code-to-code verifications. All current analyses have focused on code-to-code verifications, with additional verification and validation studies planned. The analysis of TREAT with PROTEUS-SN is an ongoing project. This report documents the studies that have been performed thus far, and highlights key challenges to address in future work.

  4. Single Event Transient Analysis of an SOI Operational Amplifier for Use in Low-Temperature Martian Exploration

    NASA Technical Reports Server (NTRS)

    Laird, Jamie S.; Scheik, Leif; Vizkelethy, Gyorgy; Mojarradi, Mohammad M; Chen, Yuan; Miyahira, Tetsuo; Blalock, Benjamin; Greenwell, Robert; Doyle, Barney

    2006-01-01

    The next generation of Martian rover#s to be launched by JPL are to examine polar regions where temperatures are extremely low and the absence of an earth-like atmosphere results in high levels of cosmic radiation at ground level. Cosmic rays lead to a plethora of radiation effects including Single Event Transients (SET) which can severely degrade microelectronic functionality. As such, a radiation-hardened, temperature compensated CMOS Single-On-Insulator (SOI) Operational Amplifier has been designed for JPL by the University of Tennessee and fabricated by Honeywell using the SOI V process. SOI technology has been shownto be far less sensitive to transient effects than both bulk and epilayer Si. Broad beam heavy-ion tests at the University of Texas A&M using Kr and Xebeams of energy 25MeV/amu were performed to ascertain the duration and severity of the SET for the op-amp configured for a low and high gain application. However, some ambiguity regarding the location of transient formation required the use of a focused MeV ion microbeam. A 36MeV O6(+) microbeam. the Sandia National Laboratory (SNL) was used to image and verify regions of particular concern. This is a viewgraph presentation

  5. Single-Molecule Counting of Point Mutations by Transient DNA Binding

    PubMed Central

    Su, Xin; Li, Lidan; Wang, Shanshan; Hao, Dandan; Wang, Lei; Yu, Changyuan

    2017-01-01

    High-confidence detection of point mutations is important for disease diagnosis and clinical practice. Hybridization probes are extensively used, but are hindered by their poor single-nucleotide selectivity. Shortening the length of DNA hybridization probes weakens the stability of the probe-target duplex, leading to transient binding between complementary sequences. The kinetics of probe-target binding events are highly dependent on the number of complementary base pairs. Here, we present a single-molecule assay for point mutation detection based on transient DNA binding and use of total internal reflection fluorescence microscopy. Statistical analysis of single-molecule kinetics enabled us to effectively discriminate between wild type DNA sequences and single-nucleotide variants at the single-molecule level. A higher single-nucleotide discrimination is achieved than in our previous work by optimizing the assay conditions, which is guided by statistical modeling of kinetics with a gamma distribution. The KRAS c.34 A mutation can be clearly differentiated from the wild type sequence (KRAS c.34 G) at a relative abundance as low as 0.01% mutant to WT. To demonstrate the feasibility of this method for analysis of clinically relevant biological samples, we used this technology to detect mutations in single-stranded DNA generated from asymmetric RT-PCR of mRNA from two cancer cell lines. PMID:28262827

  6. Single-Molecule Counting of Point Mutations by Transient DNA Binding

    NASA Astrophysics Data System (ADS)

    Su, Xin; Li, Lidan; Wang, Shanshan; Hao, Dandan; Wang, Lei; Yu, Changyuan

    2017-03-01

    High-confidence detection of point mutations is important for disease diagnosis and clinical practice. Hybridization probes are extensively used, but are hindered by their poor single-nucleotide selectivity. Shortening the length of DNA hybridization probes weakens the stability of the probe-target duplex, leading to transient binding between complementary sequences. The kinetics of probe-target binding events are highly dependent on the number of complementary base pairs. Here, we present a single-molecule assay for point mutation detection based on transient DNA binding and use of total internal reflection fluorescence microscopy. Statistical analysis of single-molecule kinetics enabled us to effectively discriminate between wild type DNA sequences and single-nucleotide variants at the single-molecule level. A higher single-nucleotide discrimination is achieved than in our previous work by optimizing the assay conditions, which is guided by statistical modeling of kinetics with a gamma distribution. The KRAS c.34 A mutation can be clearly differentiated from the wild type sequence (KRAS c.34 G) at a relative abundance as low as 0.01% mutant to WT. To demonstrate the feasibility of this method for analysis of clinically relevant biological samples, we used this technology to detect mutations in single-stranded DNA generated from asymmetric RT-PCR of mRNA from two cancer cell lines.

  7. 40 CFR 86.1333-2010 - Transient test cycle generation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Emission Regulations for New Otto-Cycle and Diesel Heavy-Duty Engines; Gaseous and Particulate... cycles. The heavy-duty transient engine cycles for Otto-cycle and diesel engines are listed in appendix...

  8. 40 CFR 86.1333-2010 - Transient test cycle generation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Emission Regulations for New Otto-Cycle and Diesel Heavy-Duty Engines; Gaseous and Particulate... cycles. The heavy-duty transient engine cycles for Otto-cycle and diesel engines are listed in appendix...

  9. 40 CFR 86.1333-2010 - Transient test cycle generation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Emission Regulations for New Otto-Cycle and Diesel Heavy-Duty Engines; Gaseous and Particulate... cycles. The heavy-duty transient engine cycles for Otto-cycle and diesel engines are listed in appendix...

  10. 40 CFR 86.1333-2010 - Transient test cycle generation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Emission Regulations for New Otto-Cycle and Diesel Heavy-Duty Engines; Gaseous and Particulate... cycles. The heavy-duty transient engine cycles for Otto-cycle and diesel engines are listed in appendix...

  11. Mechanical transients of single toad stomach smooth muscle cells. Effects of lowering temperature and extracellular calcium

    PubMed Central

    1990-01-01

    Smooth muscle's slow, economical contractions may relate to the kinetics of the crossbridge cycle. We characterized the crossbridge cycle in smooth muscle by studying tension recovery in response to a small, rapid length change (i.e., tension transients) in single smooth muscle cells from the toad stomach (Bufo marinus). To confirm that these tension transients reflect crossbridge kinetics, we examined the effect of lowering cell temperature on the tension transient time course. Once this was confirmed, cells were exposed to low extracellular calcium [( Ca2+]o) to determine whether modulation of the cell's shortening velocity by changes in [Ca2+]o reflected the calcium sensitivity of one or more steps in the crossbridge cycle. Single smooth muscle cells were tied between an ultrasensitive force transducer and length displacement device after equilibration in temperature-controlled physiological saline having either a low (0.18 mM) or normal (1.8 mM) calcium concentration. At the peak of isometric force, after electrical stimulation, small, rapid (less than or equal to 1.8% cell length in 3.6 ms) step stretches and releases were imposed. At room temperature (20 degrees C) in normal [Ca2+]o, tension recovery after the length step was described by the sum of two exponentials with rates of 40-90 s-1 for the fast phase and 2-4 s-1 for the slow phase. In normal [Ca2+]o but at low temperature (10 degrees C), the fast tension recovery phase slowed (apparent Q10 = 1.9) for both stretches and releases whereas the slow tension recovery phase for a release was only moderately affected (apparent Q10 = 1.4) while unaffected for a stretch. Dynamic stiffness was determined throughout the time course of the tension transient to help correlate the tension transient phases with specific step(s) in the crossbridge cycle. The dissociation of tension and stiffness, during the fast tension recovery phase after a release, was interpreted as evidence that this recovery phase resulted from

  12. TS-1 and TS-2 transient overpower tests on FFTF fuel

    SciTech Connect

    Pitner, A.L.; Ferrell, P.C.; Culley, G.E.; Weber, E.T.

    1985-11-01

    The TS-1 and TS-2 Transient Reactor Test Facility (TREAT) experiments were conducted on irradiated Fast Flux Test Facility (FFTF) fuel pins to characterize their failure behavior when subjected to hypothetical 5%/s transient overpower conditions. The TS-1 test employed a near-fresh (2 MWd/kg) fuel pin, while the TS-2 test used a medium-burnup (58 MWd/kg) fuel pin. Transient conditions were closely matched between the two experiments to provide a direct comparison of burnup effects on the failure response.

  13. A 10 GHz bandwidth, single transient, digitized oscilloscope with 20 GHz capability

    SciTech Connect

    Hudson, C.L.; Kocimski, S.M.; Spector, J.; Thomas, J.B.; Woodstra, R.R.

    1993-12-31

    EG&G/EM has developed an oscilloscope with a {minus}3 dB bandwidth greater than 10 GHz. Its rolloff characteristics are such that single-transient data greater than 20 GHz may be captured. A demountable CCD camera records the oscilloscope trace and is provided with PC-compatible capture and data processing software. The capabilities of the oscilloscope, camera, and its processing software are described and examples of the system`s performance is shown.

  14. Transient computation fluid dynamics modeling of a single proton exchange membrane fuel cell with serpentine channel

    NASA Astrophysics Data System (ADS)

    Hu, Guilin; Fan, Jianren

    The proton exchange membrane fuel cell (PEMFC) has become a promising candidate for the power source of electrical vehicles because of its low pollution, low noise and especially fast startup and transient responses at low temperatures. A transient, three-dimensional, non-isothermal and single-phase mathematical model based on computation fluid dynamics has been developed to describe the transient process and the dynamic characteristics of a PEMFC with a serpentine fluid channel. The effects of water phase change and heat transfer, as well as electrochemical kinetics and multicomponent transport on the cell performance are taken into account simultaneously in this comprehensive model. The developed model was employed to simulate a single laboratory-scale PEMFC with an electrode area about 20 cm 2. The dynamic behavior of the characteristic parameters such as reactant concentration, pressure loss, temperature on the membrane surface of cathode side and current density during start-up process were computed and are discussed in detail. Furthermore, transient responses of the fuel cell characteristics during step changes and sinusoidal changes in the stoichiometric flow ratio of the cathode inlet stream, cathode inlet stream humidity and cell voltage are also studied and analyzed and interesting undershoot/overshoot behavior of some variables was found. It was also found that the startup and transient response time of a PEM fuel cell is of the order of a second, which is similar to the simulation results predicted by most models. The result is an important guide for the optimization of PEMFC designs and dynamic operation.

  15. 40 CFR Appendix E to Subpart S of... - Transient Test Driving Cycle

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... E to Subpart S of Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.../Maintenance Program Requirements Pt. 51, Subpt. S, App. E Appendix E to Subpart S of Part 51—Transient Test Driving Cycle (I) Driver's trace. All excursions in the transient driving cycle shall be evaluated by...

  16. EMTP transient modeling of a distance relay and a comparison with EMTP laboratory testing. [ElectroMagnetics Transient Program

    SciTech Connect

    Wilson, R.E. ); Nordstrom, J.M. )

    1993-07-01

    This paper reports on a method to test the transient performance of a sampled-data relay. A model of one measuring unit of a digital relay was created on a personal computer. The simulations are compared with laboratory results obtained by applying digitally generated waveforms to the actual relay. Computer modelling of the digital relay is done within the Models version of the Transient Analysis of Control System (TACS) subsection of the ElectroMagnetics Transient Program (EMTP). The input filter, analog to digital converter, Fourier fundamental frequency detector, and the relay measuring principle of one digital microprocessor based relay are modeled. The modeling of these components within an EMTP environment represents new work. An actual 115 Kv 150 mile long transmission line was simulated using the EMTP. The faults simulated on the transmission line were applied both to the digital model of the relay and the actual relay. The physical testing used the Bonneville Power Administration (BPA) Relay Evaluation System (RES). Results from the digital relay simulation are compared with results from an actual relay. The educational value of observing relay waveforms at various stages within the simulation is discussed.

  17. Single-Cycle Versus Multicycle Proof Testing

    NASA Technical Reports Server (NTRS)

    Hudak, S. J., Jr.; Mcclung, R. C.; Bartlett, M. L.; Fitzgerald, J. H.; Russell, D. A.

    1992-01-01

    Report compares single-cycle with multiple-cycle mechanical-stress tests of parts under mechanical stresses. Objective of proof testing: to screen out gross manufacturing or material deficiencies and provide additional assurance of quality. Report concludes that changes in distribution of crack sizes during multicycle proof testing depend on initial distribution, number of cycles, relationship between resistance of material and elastic/plastic fracture-mechanics parameter, relationship between load control and displacement control, and magnitude of applied load or displacement. Whether single-cycle or multicycle testing used depends on shape, material, and technique of fabrication of components tested.

  18. Design and calibration of a novel transient radiative heat flux meter for a spacecraft thermal test.

    PubMed

    Sheng, Chunchen; Hu, Peng; Cheng, Xiaofang

    2016-06-01

    Radiative heat flux measurement is significantly important for a spacecraft thermal test. To satisfy the requirements of both high accuracy and fast response, a novel transient radiative heat flux meter was developed. Its thermal receiver consists of a central thermal receiver and two thermal guarded annular plates, which ensure the temperature distribution of the central thermal receiver to be uniform enough for reasonably applying lumped heat capacity method in a transient radiative heat flux measurement. This novel transient radiative heat flux meter design can also take accurate measurements regardless of spacecraft surface temperature and incident radiation spectrum. The measurement principle was elaborated and the coefficients were calibrated. Experimental results from testing a blackbody furnace and an Xenon lamp show that this novel transient radiative heat flux meter can be used to measure transient radiative heat flux up to 1400 W/m(2) with high accuracy and the response time of less than 10 s.

  19. Design and calibration of a novel transient radiative heat flux meter for a spacecraft thermal test

    NASA Astrophysics Data System (ADS)

    Sheng, Chunchen; Hu, Peng; Cheng, Xiaofang

    2016-06-01

    Radiative heat flux measurement is significantly important for a spacecraft thermal test. To satisfy the requirements of both high accuracy and fast response, a novel transient radiative heat flux meter was developed. Its thermal receiver consists of a central thermal receiver and two thermal guarded annular plates, which ensure the temperature distribution of the central thermal receiver to be uniform enough for reasonably applying lumped heat capacity method in a transient radiative heat flux measurement. This novel transient radiative heat flux meter design can also take accurate measurements regardless of spacecraft surface temperature and incident radiation spectrum. The measurement principle was elaborated and the coefficients were calibrated. Experimental results from testing a blackbody furnace and an Xenon lamp show that this novel transient radiative heat flux meter can be used to measure transient radiative heat flux up to 1400 W/m2 with high accuracy and the response time of less than 10 s.

  20. Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers.

    PubMed

    Stary, Creed M; Hogan, Michael C

    2016-05-15

    The intrinsic activating factors that induce transcription of heat shock protein 72 (HSP72) in skeletal muscle following exercise remain unclear. We hypothesized that the cytosolic Ca(2+) transient that occurs with depolarization is a determinant. We utilized intact, single skeletal muscle fibers from Xenopus laevis to test the role of the cytosolic Ca(2+) transient and several other exercise-related factors (fatigue, hypoxia, AMP kinase, and cross-bridge cycling) on the activation of HSP72 transcription. HSP72 and HSP60 mRNA levels were assessed with real-time quantitative PCR; cytosolic Ca(2+) concentration ([Ca(2+)]cyt) was assessed with fura-2. Both fatiguing and nonfatiguing contractions resulted in a significant increase in HSP72 mRNA. As expected, peak [Ca(2+)]cyt remained tightly coupled with peak developed tension in contracting fibers. Pretreatment with N-benzyl-p-toluene sulfonamide (BTS) resulted in depressed peak developed tension with stimulation, while peak [Ca(2+)]cyt remained largely unchanged from control values. Despite excitation-contraction uncoupling, BTS-treated fibers displayed a significant increase in HSP72 mRNA. Treatment of fibers with hypoxia (Po2: <3 mmHg) or AMP kinase activation had no effect on HSP72 mRNA levels. These results suggest that the intermittent cytosolic Ca(2+) transient that occurs with skeletal muscle depolarization provides a sufficient activating stimulus for HSP72 transcription. Metabolic or mechanical factors associated with fatigue development and cross-bridge cycling likely play a more limited role.

  1. Single pellet crush strength testing of catalysts

    SciTech Connect

    Brienza, P.K. )

    1988-09-01

    ASTM D-32 Committee on Catalysts has developed a standard test method for single pellet crush strength for formed catalyst shapes. This standard was issued under the fixed designation D 4179. The method is applicable to regular catalyst shapes such as tablets and spheres. Extrudates, granular materials, and other irregular shapes are excluded. The committee continues to work on the development of a method for the single pellet crush testing of extrudates.

  2. Comparison of Single-Event Transients Induced in an Operational Amplifier (LM124) by Pulsed Laser Light and a Broad Beam of Heavy Ions

    NASA Technical Reports Server (NTRS)

    Buchner, Steve; McMorrow, Dale; Poivey, Christian; Howard, James, Jr.; Pease, Rom; Savage, Mark; Boulghassoul, Younis; Massengill, Lloyd

    2003-01-01

    A comparison of transients from heavy-ion and pulsed-laser testing shows good agreement for many different voltage configurations. The agreement is illustrated by comparing directly individual transients and plots of transient amplitude versus width.

  3. Mechanism of single-event transient pulse quenching between dummy gate isolated logic nodes

    NASA Astrophysics Data System (ADS)

    Chen, Jian-Jun; Chi, Ya-Qing; Liang, Bin

    2015-01-01

    As integrated circuits scale down in size, a single high-energy ion strike often affects multiple adjacent logic nodes. The so-called single-event transient (SET) pulse quenching induced by single-event charge sharing collection has been widely studied. In this paper, SET pulse quenching enhancement is found in dummy gate isolated adjacent logic nodes compared with that isolated by the common shallow trench isolation (STI). The physical mechanism is studied in depth and this isolation technique is explored for SET mitigation in combinational standard cells. Three-dimensional (3D) technology computer-aided design simulation (TCAD) results show that this technique can achieve efficient SET mitigation. Project supported by the National Natural Science Foundation of China (Grant No. 61376109) and the Opening Project of National Key Laboratory of Science and Technology on Reliability Physics and Application Technology of Electrical Component, China (Grant No. ZHD201202).

  4. Data acquisition and interpretation of horizontal well pressure-transient tests

    SciTech Connect

    Lichtenberger, G.J. )

    1994-02-01

    For both vertical and horizontal wells, pressure-transient testing is a powerful tool for evaluating in-situ reservoir and wellbore parameters that describe the production characteristics of a well. Although many operators use horizontal well technology, many engineers consider pressure-transient testing of horizontal wells impractical and too complex. Experience has shown, however, that with adequate test planning, based on the concept of low regimes and focused on optimizing test conditions, horizontal well testing can be as successful as vertical well testing. Using the concept of flow regimes and drawing on analogies with vertical wells, this paper reviews the pressure-transient behavior of horizontal wells. Practical guidelines are given for planning, executing, and interpreting horizontal well tests. The application of various interpretation techniques is illustrated with field examples.

  5. Simulation Model for Prediction of Transient Performance Characteristics of Single-Phase Shaded Pole Motor

    NASA Astrophysics Data System (ADS)

    Sarac, Vasilija; Atanasova-Pacemska, Tatjana

    2016-07-01

    Paper proposes mathematical model of single phase shaded pole motor suitable for analysis of motor dynamic behavior. Derived mathematical model from d-q reference frame theory is applied at motor simulation model. Derived simulation model enables analysis of transient performance characteristics of motor currents, speed and electromagnetic torque under different operating regimes. Obtained results from the simulation are compared with data from analytical calculations based on method of symmetrical components and data from experiment for the purpose of verification of the simulation model. Simulation model is useful for studying the effect of parameters on motor starting and running characteristics at different types of loads.

  6. Single Event Effect (SEE) Test Planning 101

    NASA Technical Reports Server (NTRS)

    LaBel, Kenneth A.; Pellish, Jonathan; Berg, Melanie D.

    2011-01-01

    This is a course on SEE Test Plan development. It is an introductory discussion of the items that go into planning an SEE test that should complement the SEE test methodology used. Material will only cover heavy ion SEE testing and not proton, LASER, or other though many of the discussed items may be applicable. While standards and guidelines for how-to perform single event effects (SEE) testing have existed almost since the first cyclotron testing, guidance on the development of SEE test plans has not been as easy to find. In this section of the short course, we attempt to rectify this lack. We consider the approach outlined here as a "living" document: mission specific constraints and new technology related issues always need to be taken into account. We note that we will use the term "test planning" in the context of those items being included in a test plan.

  7. 40 CFR 1048.510 - What transient duty cycles apply for laboratory testing?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... that the test is valid. (c) Warm up the test engine as follows before running a transient test: (1... operates over the prescribed duty cycle. For severe-duty engines, this engine warm-up procedure may include.... For example, if an engine starting at room temperature warms up enough in three minutes to...

  8. 40 CFR 1048.510 - What transient duty cycles apply for laboratory testing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... that the test is valid. (c) Warm up the test engine as follows before running a transient test: (1... operates over the prescribed duty cycle. For severe-duty engines, this engine warm-up procedure may include.... For example, if an engine starting at room temperature warms up enough in three minutes to...

  9. Adaptive identification and interpretation of pressure transient tests of horizontal wells: challenges and perspectives

    NASA Astrophysics Data System (ADS)

    Sergeev, V. L.; Van Hoang, Dong

    2016-09-01

    The paper deals with a topical issue of defining oil reservoir properties during transient tests of horizontal wells equipped with information-measuring systems and reducing well downtime. The aim is to consider challenges and perspectives of developing models and algorithms for adaptive identification and interpretation of transient tests in horizontal wells with pressure buildup curve analysis. The models and algorithms should allow analyzing flow behavior, defining oil reservoir properties and determining well test completion time, as well as reducing well downtime. The present paper is based on the previous theoretical and practical findings in the spheres of transient well testing, systems analysis, system identification, function optimization and linear algebra. Field data and results of transient well tests with pressure buildup curve analysis have also been considered. The suggested models and algorithms for adaptive interpretation of transient tests conducted in horizontal wells with resulting pressure buildup curve make it possible to analyze flow behavior, as well as define the reservoir properties and determine well test completion time. The algorithms for adaptive interpretation are based on the integrated system of radial flow PBC models with time- dependent variables, account of additional a priori information and estimates of radial flow permeability. Optimization problems are solved with the case study of PBC interpretation for five horizontal wells of the Verkhnechonsk field.

  10. Transient testing of the FFTF for decay-heat removal by natural convection

    SciTech Connect

    Beaver, T R; Johnson, H G; Stover, R L

    1982-06-01

    This paper reports on the series of transient tests performed in the FFTF as a major part of the pre-operations testing program. The structure of the transient test program was designed to verify the capability of the FFTF to safely remove decay heat by natural convection. The series culminated in a scram from full power to complete natural convection in the plant, simulating a loss of all electrical power. Test results and acceptance criteria related to the verification of safe decay heat removal are presented.

  11. Combined single channel and single molecule detection identifies subunit composition of STIM1-activated transient receptor potential canonical (TRPC) channels.

    PubMed

    Asanov, Alexander; Sampieri, Alicia; Moreno, Claudia; Pacheco, Jonathan; Salgado, Alfonso; Sherry, Ryan; Vaca, Luis

    2015-01-01

    Depletion of intracellular calcium ion stores initiates a rapid cascade of events culminating with the activation of the so-called Store-Operated Channels (SOC) at the plasma membrane. Calcium influx via SOC is essential in the initiation of calcium-dependent intracellular signaling and for the refilling of internal calcium stores, ensuring the regeneration of the signaling cascade. In spite of the significance of this evolutionary conserved mechanism, the molecular identity of SOC has been the center of a heated controversy spanning over the last 20 years. Initial studies positioned some members of the transient receptor potential canonical (TRPC) channel superfamily of channels (with the more robust evidence pointing to TRPC1) as a putative SOC. Recent evidence indicates that Stromal Interacting Molecule 1 (STIM1) activates some members from the TRPC family of channels. However, the exact subunit composition of TRPC channels remains undetermined to this date. To identify the subunit composition of STIM1-activated TRPC channels, we developed novel method, which combines single channel electrophysiological measurements based on the patch clamp technique with single molecule fluorescence imaging. We termed this method Single ion Channel Single Molecule Detection technique (SC-SMD). Using SC-SMD method, we have obtained direct evidence of the subunit composition of TRPC channels activated by STIM1. Furthermore, our electrophysiological-imaging SC-SMD method provides evidence at the molecular level of the mechanism by which STIM1 and calmodulin antagonize to modulate TRPC channel activity.

  12. Single event phenomena: Testing and prediction

    NASA Technical Reports Server (NTRS)

    Kinnison, James D.

    1992-01-01

    Highly integrated microelectronic devices are often used to increase the performance of satellite systems while reducing the system power dissipation, size, and weight. However, these devices are usually more susceptible to radiation than less integrated devices. In particular, the problem of sensitivity to single event upset and latchup is greatly increased as the integration level is increased. Therefore, a method for accurately evaluating the susceptibility of new devices to single event phenomena is critical to qualifying new components for use in space systems. This evaluation includes testing devices for upset or latchup and extrapolating the results of these tests to the orbital environment. Current methods for testing devices for single event effects are reviewed, and methods for upset rate prediction, including a new technique based on Monte Carlo simulation, are presented.

  13. Total Dose Effects on Single Event Transients in Digital CMOS and Linear Bipolar Circuits

    NASA Technical Reports Server (NTRS)

    Buchner, S.; McMorrow, D.; Sibley, M.; Eaton, P.; Mavis, D.; Dusseau, L.; Roche, N. J-H.; Bernard, M.

    2009-01-01

    This presentation discusses the effects of ionizing radiation on single event transients (SETs) in circuits. The exposure of integrated circuits to ionizing radiation changes electrical parameters. The total ionizing dose effect is observed in both complementary metal-oxide-semiconductor (CMOS) and bipolar circuits. In bipolar circuits, transistors exhibit grain degradation, while in CMOS circuits, transistors exhibit threshold voltage shifts. Changes in electrical parameters can cause changes in single event upset(SEU)/SET rates. Depending on the effect, the rates may increase or decrease. Therefore, measures taken for SEU/SET mitigation might work at the beginning of a mission but not at the end following TID exposure. The effect of TID on SET rates should be considered if SETs cannot be tolerated.

  14. An Investigation of the Ability to Recover from Transients Following Failures for Single-Pilot Rotorcraft

    NASA Technical Reports Server (NTRS)

    Mansur, M. Hossein; Schroeder, Jeffery A.

    1988-01-01

    A moving-base simulation was conducted to investigate a pilot's ability to recover from transients following single-axis hard-over failures of the flight-control system. The investigation was performed in conjunction with a host simulation that examined the influence of control modes on a single pilot's ability to perform various mission elements under high-workload conditions. The NASA Ames large-amplitude-motion Vertical Motion Simulator (VMS) was utilized, and the experimental variables were the failure axis, the severity of the failure, and the airspeed at which the failure occurred. Other factors, such as pilot workload and terrain and obstacle proximity at the time of failure, were kept as constant as possible within the framework of the host simulation task scenarios. No explicit failure warnings were presented to the pilot. Data from the experiment are shown, and pilot ratings are compared with the proposed handling-qualities requirements for military rotorcraft. Results indicate that the current proposed failure transient requirements may need revision.

  15. 40 CFR 86.1333-90 - Transient test cycle generation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... test. The torque and rpm feedback signals may be filtered. (d) Idle Speed Enhancement Devices (e.g... feedback torque equal to zero (using, for example, clutch disengagement, speed to torque control switching... longer, the average feedback torque must be within ±10 ft-lbs of zero. To allow for transition, up to...

  16. Single-heater test final report

    SciTech Connect

    Blair, S. C.; Buscheck, T. A.; DeLoach, L. D.; Lin, W.; Ramirez, A. I.

    1998-09-01

    The Single-Heater Test (SHT) was one phase of the field-scale thermal testing program of the Yucca Mountain Site Characterization Project. The primary purpose of the SHT was to study the thermomechanical (TM) behavior of the densely welded, non-lithophysal Topopah Spring tuff at the Exploratory Studies Facility. The SHT was also used as a shake-down for testing thermal-hydrologic-chemical-mechanical processes in situ, testing that will be conducted in the Drift-Scale Test. In the SHT, a line-heat source 5-m long was emplaced in a pillar and used to heat the pillar for approximately nine months. The thermal field was relatively cylindrical about the line-heat source. The heater was turned off after nine months of heating, and the rock mass was monitored during the cool-down for another nine months, until May 28, 1997, when the test was terminated.

  17. Transient analysis of an IVHM grapple impact test

    NASA Technical Reports Server (NTRS)

    Hill, R. G.

    1972-01-01

    A lumped mass model was used to represent the impact condition between a fuel duct and an IVHM in-vessel fuel handling machine. The nonlinear effects of a Bellville spring and the free fall impact of the fuel duct on the IVHM were included. The purpose of the tests was to determine the loads on the fuel duct due to the impact. A comparison between experimental and theoretical results is presented.

  18. Comparison of Above Bandgap Laser and MeV Ion Induced Single Event Transients in High-Speed Si Photonic Devices

    NASA Technical Reports Server (NTRS)

    Laird, Jamie S.; Hirao, Toshio; Onoda, Shinobu; Itoh, Hisayoshi; Edmonds, Larry; Johnston, Allan

    2006-01-01

    We illustrate inherent differences between Single Event Transients generated by an above bandgap picosecond lasers and MeV heavy ions by comparing transient currents collected with an ion microbeam and picosecond laser with varying track waist.

  19. Laboratory tests for single-event effects

    SciTech Connect

    Buchner, S.; McMorrow, D.; Melinger, J.; Campbell, A.B.

    1996-04-01

    Integrated circuits are currently tested at accelerators for their susceptibility to single-event effects (SEE`s). However, because of the cost and limited accessibility associated with accelerator testing, there is considerable interest in developing alternate testing methods. Two laboratory techniques for measuring SEE, one involving a pulsed laser and the other {sup 252}Cf, are described in detail in this paper. The pulsed laser provides information on the spatial and temporal dependence of SEE, information that has proven invaluable in understanding and mitigating SEE in spite of the differences in the physical mechanisms responsible for SEE induced by light and by ions. Considerable effort has been expended on developing {sup 252}Cf as a laboratory test for SEE, but the technique has not found wide use because it is severely limited by the low energy and short range of the emitted ions that are unable to reach junctions either covered with dielectric layers or deep below the surface. In fact, there are documented cases where single-event latchup (SEL) testing with {sub 252}Cf gave significantly different results from accelerator testing. A detailed comparison of laboratory and accelerator SEE data is presented in this review in order to establish the limits of each technique.

  20. NEXT Single String Integration Test Results

    NASA Technical Reports Server (NTRS)

    Soulas, George C.; Patterson, Michael J.; Pinero, Luis; Herman, Daniel A.; Snyder, Steven John

    2010-01-01

    As a critical part of NASA's Evolutionary Xenon Thruster (NEXT) test validation process, a single string integration test was performed on the NEXT ion propulsion system. The objectives of this test were to verify that an integrated system of major NEXT ion propulsion system elements meets project requirements, to demonstrate that the integrated system is functional across the entire power processor and xenon propellant management system input ranges, and to demonstrate to potential users that the NEXT propulsion system is ready for transition to flight. Propulsion system elements included in this system integration test were an engineering model ion thruster, an engineering model propellant management system, an engineering model power processor unit, and a digital control interface unit simulator that acted as a test console. Project requirements that were verified during this system integration test included individual element requirements ; integrated system requirements, and fault handling. This paper will present the results of these tests, which include: integrated ion propulsion system demonstrations of performance, functionality and fault handling; a thruster re-performance acceptance test to establish baseline performance: a risk-reduction PMS-thruster integration test: and propellant management system calibration checks.

  1. Transient getter scheme for the Tokamak Fusion Test Reactor

    SciTech Connect

    Cecchi, J.L.; Cohen, S.A.; Sredniawski, J.J.

    1980-01-01

    The ability of the Tokamak Fusion Test Reactor (TFTR) to attain the largest fusion power gain depends critically on minimizing plasma contamination and controlling the densities of the reacting deuterium and tritium. Experiments on a number of tokamaks have demonstrated that gettering over an appreciable surface area (greater than or equal to 10%) of the vacuum vessel greatly facilitates both of these objectives. One particular problem in implementing a surface pumping system in TFTR, however, is a restriction on the maximum allowable tritium content of the getter. This restriction could require regeneration of the absorbed tritium after as few as 50 machine pulses. We have developed a scheme utilizing SAES Zr/Al getter modules which obviates the need for such frequent interruptions of machine operation by taking advantage of the pulsed operation of TFTR. With the Zr/Al getter at temperatures between 500/sup 0/C to 600/sup 0/C it is possible to achieve a quasi-steady state in the tritium loading where the quantity of tritium desorbed between pulses is equal to the quantity which is absorbed during a pulse. Since frequent thermal cycling is not required, this scheme also reduces the possibility of Zr/Al getter material fatigue.

  2. Transient getter scheme for the Tokamak Fusion Test Reactor

    SciTech Connect

    Cecchi, J.L.; Cohen, S.A.; Sredniawski, J.J.

    1980-01-01

    The ability of the Tokamak Fusion Test Reactor (TFTR) to attain the largest fusion power gain depends critically on minimizing plasma contamination and controlling the densities of the reacting deuterium and tritium. Experiments on a number of tokamaks have demonstrated that gettering over an appreciable surface area (> or = 10%) of the vacuum vessel greatly facilitates both of these objectives. One particular problem in implementing a surface pumping system in TFTR, however, is a restriction on the maximum allowable tritium content of the getter. This restriction could require regeneration of the absorbed tritium after as few as 50 machine pulses. We have developed a scheme utilizing SAES Zr/Al getter modules which obviates the need for such frequent interruptions of machine operation by taking advantage of the pulsed operation of TFTR. With the Zr/Al getter at temperatures between 500/sup 0/--600/sup 0/C it is possible to achieve a quasisteady state in the tritium loading where the quantity of tritium desorbed between pulses is equal to the quantity which is absorbed during a pulse. Since frequent thermal cycling is not required, this scheme also reduces the possibility of Zr/Al getter material fatigue.

  3. Method of Generating Transient Equivalent Sink and Test Target Temperatures for Swift BAT

    NASA Technical Reports Server (NTRS)

    Choi, Michael K.

    2004-01-01

    The NASA Swift mission has a 600-km altitude and a 22 degrees maximum inclination. The sun angle varies from 45 degrees to 180 degrees in normal operation. As a result, environmental heat fluxes absorbed by the Burst Alert Telescope (BAT) radiator and loop heat pipe (LHP) compensation chambers (CCs) vary transiently. Therefore the equivalent sink temperatures for the radiator and CCs varies transiently. In thermal performance verification testing in vacuum, the radiator and CCs radiated heat to sink targets. This paper presents an analytical technique for generating orbit transient equivalent sink temperatures and a technique for generating transient sink target temperatures for the radiator and LHP CCs. Using these techniques, transient target temperatures for the radiator and LHP CCs were generated for three thermal environmental cases: worst hot case, worst cold case, and cooldown and warmup between worst hot case in sunlight and worst cold case in the eclipse, and three different heat transport values: 128 W, 255 W, and 382 W. The 128 W case assumed that the two LHPs transport 255 W equally to the radiator. The 255 W case assumed that one LHP fails so that the remaining LHP transports all the waste heat from the detector array to the radiator. The 382 W case assumed that one LHP fails so that the remaining LHP transports all the waste heat from the detector array to the radiator, and has a 50% design margin. All these transient target temperatures were successfully implemented in the engineering test unit (ETU) LHP and flight LHP thermal performance verification tests in vacuum.

  4. Single event transient modeling and mitigation techniques for mixed-signal delay locked loop (DLL) and clock circuits

    NASA Astrophysics Data System (ADS)

    Maillard, Pierre

    The purpose of this PhD work has been to investigate, model, test, develop and provide hardening techniques and guidelines for the mitigation of single event transients (SETs) in analog mixed-signal (AMS) delay locked loops (DLLs) for radiation-hardened applications. Delay-locked-loops (DLLs) are circuit substructures that are present in complex ASIC and system-on-a-chip designs. These circuits are widely used in on-chip clock distribution systems to reduce clock skew, to reduce jitter noise, and to recover clock signals at regional points within a global clock distribution system. DLLs are critical to the performance of many clock distribution systems, and in turn, the overall performance of the associated integrated system; as such, complex systems often employ multiple DLLs for clock deskew and distribution tasks. In radiation environments such as on-orbit, these critical circuits represent at-risk points of malfunction for large sections of integrated circuits due to vulnerabilities to radiation-generated transients (i.e. single event transients) that fan out across the system. The analysis of single event effects in analog DLLs has shown that each DLL sub-circuit primitive is vulnerable to single event transients. However, we have identified the voltage controlled delay line (VCDL) sub-circuit as the most sensitive to radiation-induced single event effects generating missing clock pulses that increase with the operating frequency of the circuit. This vulnerability increases with multiple instantiation of DLLs as clock distribution nodes throughout an integrated system on a chip. To our knowledge, no complete work in the rad-hard community regarding the hardening of mixed-signal DLLs against single event effects (missing pulses) has been developed. Most of the work present in the literature applies the "brute force" and well-established digital technique of triple modular redundancy (TMR) to the digital subcomponents. We have developed two novel design

  5. Single-molecule enzymology of steroid transforming enzymes: Transient kinetic studies and what they tell us.

    PubMed

    Penning, Trevor M

    2016-07-01

    Structure-function studies on steroid transforming enzymes often use site-directed mutagenesis to inform mechanisms of catalysis and effects on steroid binding, and data are reported in terms of changes in steady state kinetic parameters kcat, Km and kcat/Km. However, this dissection of function is limited since kcat is governed by the rate-determining step and Km is a complex macroscopic kinetic constant. Often site-directed mutagenesis can lead to a change in the rate-determining step which cannot be revealed by just reporting a decrease in kcat alone. These issues are made more complex when it is considered that many steroid transforming enzymes have more than one substrate and product. We present the case for using transient-kinetics performed with stopped-flow spectrometry to assign rate constants to discrete steps in these multi-substrate reactions and their use to interpret enzyme mechanism and the effects of disease and engineered mutations. We demonstrate that fluorescence kinetic transients can be used to measure ligand binding that may be accompanied by isomerization steps, revealing the existence of new enzyme intermediates. We also demonstrate that single-turnover reactions can provide a klim for the chemical step and Ks for steroid-substrate binding and that when coupled with kinetic isotope effect measurements can provide information on transition state intermediates. We also demonstrate how multiple turnover experiments can provide evidence for either "burst-phase" kinetics, which can reveal a slow product release step, or linear-phase kinetics, in which the chemical step can be rate-determining. With these assignments it becomes more straightforward to analyze the effects of mutations. We use examples from the hydroxysteroid dehydrogenases (AKR1Cs) and human steroid 5β-reductase (AKR1D1) to illustrate the utility of the approach, which are members of the aldo-keto reductase (AKR) superfamily.

  6. Total Dose Effects on Single Event Transients in Linear Bipolar Systems

    NASA Technical Reports Server (NTRS)

    Buchner, Stephen; McMorrow, Dale; Bernard, Muriel; Roche, Nicholas; Dusseau, Laurent

    2008-01-01

    Single Event Transients (SETs) originating in linear bipolar integrated circuits are known to undermine the reliability of electronic systems operating in the radiation environment of space. Ionizing particle radiation produces a variety of SETs in linear bipolar circuits. The extent to which these SETs threaten system reliability depends on both their shapes (amplitude and width) and their threshold energies. In general, SETs with large amplitudes and widths are the most likely to propagate from a bipolar circuit's output through a subsystem. The danger these SET pose is that, if they become latched in a follow-on circuit, they could cause an erroneous system response. Long-term exposure of linear bipolar circuits to particle radiation produces total ionizing dose (TID) and/or displacement damage dose (DDD) effects that are characterized by a gradual degradation in some of the circuit's electrical parameters. For example, an operational amplifier's gain-bandwidth product is reduced by exposure to ionizing radiation, and it is this reduction that contributes to the distortion of the SET shapes. In this paper, we compare SETs produced in a pristine LM124 operational amplifier with those produced in one exposed to ionizing radiation for three different operating configurations - voltage follower (VF), inverter with gain (IWG), and non-inverter with gain (NIWG). Each configuration produces a unique set of transient shapes that change following exposure to ionizing radiation. An important finding is that the changes depend on operating configuration; some SETs decrease in amplitude, some remain relatively unchanged, some become narrower and some become broader.

  7. History-Dependent Excitability as a Single-Cell Substrate of Transient Memory for Information Discrimination

    PubMed Central

    Baroni, Fabiano; Torres, Joaquín J.; Varona, Pablo

    2010-01-01

    Neurons react differently to incoming stimuli depending upon their previous history of stimulation. This property can be considered as a single-cell substrate for transient memory, or context-dependent information processing: depending upon the current context that the neuron “sees” through the subset of the network impinging on it in the immediate past, the same synaptic event can evoke a postsynaptic spike or just a subthreshold depolarization. We propose a formal definition of History-Dependent Excitability (HDE) as a measure of the propensity to firing in any moment in time, linking the subthreshold history-dependent dynamics with spike generation. This definition allows the quantitative assessment of the intrinsic memory for different single-neuron dynamics and input statistics. We illustrate the concept of HDE by considering two general dynamical mechanisms: the passive behavior of an Integrate and Fire (IF) neuron, and the inductive behavior of a Generalized Integrate and Fire (GIF) neuron with subthreshold damped oscillations. This framework allows us to characterize the sensitivity of different model neurons to the detailed temporal structure of incoming stimuli. While a neuron with intrinsic oscillations discriminates equally well between input trains with the same or different frequency, a passive neuron discriminates better between inputs with different frequencies. This suggests that passive neurons are better suited to rate-based computation, while neurons with subthreshold oscillations are advantageous in a temporal coding scheme. We also address the influence of intrinsic properties in single-cell processing as a function of input statistics, and show that intrinsic oscillations enhance discrimination sensitivity at high input rates. Finally, we discuss how the recognition of these cell-specific discrimination properties might further our understanding of neuronal network computations and their relationships to the distribution and functional

  8. Properties of transient K+ currents and underlying single K+ channels in rat olfactory receptor neurons

    PubMed Central

    1991-01-01

    The transient potassium current, IK(t), of enzymatically dissociated rat olfactory receptor neurons was studied using patch-clamp techniques. Upon depolarization from negative holding potentials, IK(t) activated rapidly and then inactivated with a time course described by the sum of two exponential components with time constants of 22.4 and 143 ms. Single-channel analysis revealed a further small component with a time constant of several seconds. Steady-state inactivation was complete at -20 mV and completely removed at -80 mV (midpoint -45 mV). Activation was significant at -40 mV and appeared to reach a maximum conductance at +40 mV (midpoint -13 mV). Deactivation was described by the sum of two voltage-dependent exponential components. Recovery from inactivation was extraordinarily slow (50 s at -100 mV) and the underlying processes appeared complex. IK(t) was reduced by 4- aminopyridine and tetraethylammonium applied externally. Increasing the external K+ concentration ([K+]o) from 5 to 25 mM partially removed IK(t) inactivation, usually without affecting activation kinetics. The elevated [K+]o also hyperpolarized the steady-state inactivation curve by 9 mV and significantly depolarized the voltage dependence of activation. Single transient K+ channels, with conductances of 17 and 26 pS, were observed in excised patches and often appeared to be localized into large clusters. These channels were similar to IK(t) in their kinetic, pharmacological, and voltage-dependent properties and their inactivation was also subject to modulation by [K+]o. The properties of IK(t) imply a role in action potential repolarization and suggest it may also be important in modulating spike parameters during neuronal burst firing. A simple method is also presented to correct for errors in the measurement of whole-cell resistance (Ro) that can result when patch-clamping very small cells. The analysis revealed a mean corrected Ro of 26 G omega for these cells. PMID:1865174

  9. Transient oxidative stress and inflammation after intraperitoneal administration of multiwalled carbon nanotubes functionalized with single strand DNA in rats

    SciTech Connect

    Clichici, Simona; Biris, Alexandru Radu; Tabaran, Flaviu; Filip, Adriana

    2012-03-15

    Multi-walled carbon nanotubes (MWCNTs) are widely used for nanotechnology. Their impact on living organisms is, however, not entirely clarified. Oxidative stress and inflammation seem to be the key mechanisms involved in MWCNTs' cytotoxicity. Until present, pulmonary and skin models were the main tested experimental designs to assess carbon nanotubes' toxicity. The systemic administration of MWCNTs is essential, with respect for future medical applications. Our research is performed on Wistar rats and is focused on the dynamics of oxidative stress parameters in blood and liver and pro-inflammatory cytokines in liver, after single dose (270 mg l{sup −1}) ip administration of MWCNTs (exterior diameter 15–25 nm, interior diameter 10–15 nm, surface 88 m{sup 2} g{sup −1}) functionalized with single strand DNA (ss-DNA). The presence of MWCNTs in blood was assessed by Raman spectroscopy, while in liver histological examination and confocal microscopy were used. It was found that ss-DNA-MWCNTs induce oxidative stress in plasma and liver, with the return of the tested parameters to normal values, 6 h after ip injection of nanotubes, with the exception of reduced glutathione in plasma. The inflammatory cytokines (TNF-α, IL-1β) had a similar pattern of evolution. We also assessed the level of ERK1/2 and the phosphorylation of p65 subunit of NF-kB in liver that had a transient increase and returned to normal at the end of the tested period. Our results demonstrate that ss-DNA-MWCNTs produce oxidative stress and inflammation, but with a transient pattern. Given the fact that antioxidants modify the profile not only for oxidative stress, but also of inflammation, the dynamics of these alterations may be of practical importance for future protective strategies. -- Highlights: ► ss-DNA-MWCNTs ip administration induce oxidative stress in plasma and liver. ► ss-DNA-MWCNTs ip administration determine liver inflammation. ► ERK1/2 and p65 phosphorylated NF-KB increase

  10. Pulsed single-blow regenerator testing

    NASA Technical Reports Server (NTRS)

    Oldson, J. C.; Knowles, T. R.; Rauch, J.

    1992-01-01

    A pulsed single-blow method has been developed for testing of Stirling regenerator materials performance. The method uses a tubular flow arrangement with a steady gas flow passing through a regenerator matrix sample that packs the flow channel for a short distance. A wire grid heater spanning the gas flow channel is used to heat a plug of gas by approximately 2 K for approximately 350 ms. Foil thermocouples monitor the gas temperature entering and leaving the sample. Data analysis based on a 1D incompressible-flow thermal model allows the extraction of Stanton number. A figure of merit involving heat transfer and pressure drop is used to present results for steel screens and steel felt. The observations show a lower figure of merit for the materials tested than is expected based on correlations obtained by other methods.

  11. Testing and Lubrication for Single Race Bearings

    SciTech Connect

    Steinhoff, R.G.

    1998-03-04

    Three ES and H-compatible lubricants (Environment, Safety and Health) for single race bearing applications and one hybrid-material single race bearings were evaluated and compared against single race bearings with trichlorotrifluoroethane (Freon) deposition of low molecular weight polytetrafluoroethylene (PTFE) bearing lubricant extracted from Vydax{trademark}. Vydax is a product manufactured by DuPont consisting of various molecular weights of PTFE suspended in trichlorotrifluoroethane (Freon), which is an ozone-depleting solvent. Vydax has been used as a bearing lubricant in stronglink mechanisms since 1974. Hybrid bearings with silicon nitride balls and molded glass-nylon-Teflon retainers, bearings lubricated with titanium carbide (TiC) on the balls, bearings lubricated with sputtered MoS{sub 2} on races and retainers, and bearings lubricated with electrophoretically deposited MoS{sub 2} were evaluated. The bearings were maintained in a preloaded state in bearing cartridges during cycling and vibration tests. Bearings with electrophoretically deposited MoS{sub 2} performed as well as bearings lubricated with Vydax and were the best performing candidate. All candidates were suitable for low preload applications. Bearings with TiC coated balls and bearings lubricated with sputtered MoS{sub 2} on the races and retainers performed well at high preloads, though not as well as bearings lubricated with electrophoretic deposition of MoS{sub 2}. Bearings with silicon nitride balls were not suitable for high preload applications.

  12. Columbia University Flow Instability Experimental Program, Volume 5: Single annulus tests, steady-state test program

    SciTech Connect

    Dougherty, T.; Maciuca, C.; McAssey, E.V. Jr.; Reddy, D.G.; Yang, B.W.

    1991-07-01

    This report presents results for the steady state portion of the finless single annulus test program. The objective of the experimental study was to investigate the onset of flow instability in an annular geometry similar to the MARK 22 reactor. The test program involved testing of both a finless or ribless heater and a ribbed heater. The latter program is currently underway and will be reported separately. For finless heater, testing was conducted in both a steady state and transient mode. The present report presents steady state results for a series of experiments with uniform and asymmetric heating. The demand curves obtained under uniform heating yielded OFI flow-rates which were slightly below those obtained for a circular tube geometry with the same L/D ratio; however, the single annulus had a hydraulic diameter which was approximately fifty percent larger than the circular tube. The asymmetric heating cases were selected to provide the same average power input as the uniform cases. The results for these tests indicated that the flow-rate at OFI increased with the degree of asymmetry.

  13. PHASE I SINGLE CELL ELECTROLYZER TEST RESULTS

    SciTech Connect

    Steimke, J; Timothy Steeper, T

    2008-08-05

    This document reports the results of Phase I Single Cell testing of an SO{sub 2}-Depolarized Water Electrolyzer. Testing was performed primarily during the first quarter of FY 2008 at the Savannah River National Laboratory (SRNL) using an electrolyzer cell designed and built at SRNL. Other facility hardware were also designed and built at SRNL. This test further advances this technology for which work began at SRNL in 2005. This research is valuable in achieving the ultimate goal of an economical hydrogen production process based on the Hybrid Sulfur (HyS) Cycle. The focus of this work was to conduct single cell electrolyzer tests to further develop the technology of SO{sub 2}-depolarized electrolysis as part of the HyS Cycle. The HyS Cycle is a hybrid thermochemical cycle that may be used in conjunction with advanced nuclear reactors or centralized solar receivers to produce hydrogen by water-splitting. Like all other sulfur-based cycles, HyS utilizes the high temperature thermal decomposition of sulfuric acid to produce oxygen and regenerate sulfur dioxide. The unique aspect of HyS is the generation of hydrogen in a water electrolyzer that is operated under conditions where dissolved sulfur dioxide depolarizes the anodic reaction, resulting in substantial voltage reduction. Low cell voltage is essential for both thermodynamic efficiency and hydrogen cost. Sulfur dioxide is oxidized at the anode, producing sulfuric acid that is sent to the high temperature acid decomposition portion of the cycle. The electrolyzer cell uses the membrane electrode assembly (MEA) concept. The anode and cathode are formed by spraying platinum containing catalyst on both sides of a Proton Exchange Membrane (PEM). In most testing the material of the PEM was NafionR. The electrolyzer cell active area can be as large as 54.8 cm{sup 2}. Feed to the anode of the electrolyzer is a sulfuric acid solution containing sulfur dioxide. The partial pressure of sulfur dioxide could be varied in the

  14. The transient oxidation of single crystal NiAl+Zr. M.S. Thesis. Final Report

    NASA Technical Reports Server (NTRS)

    Doychak, J. K.

    1983-01-01

    The 800 C oxidation of oriented single crystals of Zr doped beta-NiAl was studied using transmission electron microscopy. The oxide phases and metal-oxide orientation relationships were determined to characterize the transient stages of oxidation prior to the transformation to or formation of alpha-Al2O3. On (001) and (012) metal orientations, NiAl2O4 was the first oxide to form followed by delta-Al2O3 which becomes the predominant oxide phase. All oxides were highly epitaxially related to the metal; the orientation relationships being function of parallel cation close-packed directions in the meta and oxide. On (011) and (111) metal orientations, gamma-Al2O3 became the predominant oxide phase rather than delta-Al2O3, indicating a structural stability from the highly epitaxial oxides. The relative concentration of aluminum in the oxide scales increased with time indicating preferential gamma-or delta-Al2O3 growth. The striking feature common to the orientation relationships is the alignment of 100 m and 110 ox directions, believed to result from the minimal 3 percent mismatch between the corresponding (100)m and (110)ox planes.

  15. Line-edge roughness induced single event transient variation in SOI FinFETs

    NASA Astrophysics Data System (ADS)

    Weikang, Wu; Xia, An; Xiaobo, Jiang; Yehua, Chen; Jingjing, Liu; Xing, Zhang; Ru, Huang

    2015-11-01

    The impact of process induced variation on the response of SOI FinFET to heavy ion irradiation is studied through 3-D TCAD simulation for the first time. When FinFET biased at OFF state configuration (Vgs = 0, Vds = Vdd) is struck by a heavy ion, the drain collects ionizing charges under the electric field and a current pulse (single event transient, SET) is consequently formed. The results reveal that with the presence of line-edge roughness (LER), which is one of the major variation sources in nano-scale FinFETs, the device-to-device variation in terms of SET is observed. In this study, three types of LER are considered: type A has symmetric fin edges, type B has irrelevant fin edges and type C has parallel fin edges. The results show that type A devices have the largest SET variation while type C devices have the smallest variation. Further, the impact of the two main LER parameters, correlation length and root mean square amplitude, on SET variation is discussed as well. The results indicate that variation may be a concern in radiation effects with the down scaling of feature size.

  16. Calcium transients in single fibers of low-frequency stimulated fast-twitch muscle of rat.

    PubMed

    Carroll, S; Nicotera, P; Pette, D

    1999-12-01

    Ca(2+) transients were investigated in single fibers isolated from rat extensor digitorum longus muscles exposed to chronic low-frequency stimulation for different time periods up to 10 days. Approximately 2.5-fold increases in resting Ca(2+) concentration ([Ca(2+)]) were observed 2 h after stimulation onset and persisted throughout the stimulation period. The elevated [Ca(2+)] levels were in the range characteristic of slow-twitch fibers from soleus muscle. In addition, we noticed a transitory elevation of the integral [Ca(2+)] per pulse with a maximum ( approximately 5-fold) after 1 day. Steep decreases in rate constant of [Ca(2+)] decay could be explained by an immediate impairment of Ca(2+) uptake and, with longer stimulation periods, by an additional loss of cytosolic Ca(2+) binding capacity resulting from a decay in parvalbumin content. A partial recovery of the rate constant of [Ca(2+)] decay in 10-day stimulated muscle could be explained by an increasing mitochondrial contribution to Ca(2+) sequestration.

  17. Numerical simulation and experimental study of transient liquid phase bonding of single crystal superalloys

    NASA Astrophysics Data System (ADS)

    Ghoneim, Adam

    The primary goals of the research in this dissertation are to perform a systematic study to identify and understand the fundamental cause of prolonged processing time during transient liquid phase bonding of difficult-to-bond single crystal Ni-base materials, and use the acquired knowledge to develop an effective way to reduce the isothermal solidification time without sacrificing the single crystalline nature of the base materials. To achieve these objectives, a multi-scale numerical modeling approach, that involves the use of a 2-D fully implicit moving-mesh Finite Element method and a Cellular Automata method, was developed to theoretically investigate the cause of long isothermal solidification times and determine a viable way to minimize the problem. Subsequently, the predictions of the theoretical models are experimentally validated. Contrary to previous suggestions, numerical calculations and experimental verifications have shown that enhanced intergranular diffusivity has a negligible effect on solidification time in cast superalloys and that another important factor must be responsible. In addition, it was found that the concept of competition between solute diffusivity and solubility as predicted by standard analytical TLP bonding models and reported in the literature as a possible cause of long solidification times is not suitable to explain salient experimental observations. In contrast, however, this study shows that the problem of long solidification times, which anomalously increase with temperature is fundamentally caused by departure from diffusion controlled parabolic migration of the liquid-solid interface with holding time during bonding due to a significant reduction in the solute concentration gradient in the base material. Theoretical analyses showed it is possible to minimize the solidification time and prevent formation of stray-grains in joints between single crystal substrates by using a composite powder mixture of brazing alloy and base

  18. Microscale material testing of single crystalline silicon

    NASA Astrophysics Data System (ADS)

    Yi, Taechung

    The mechanical properties of single crystalline silicon (SCS) in microscale are characterized using a uniaxial tension test. The samples are prepared using, various micromachining techniques. The dimensions of the tension specimen at the maximum stress region are 5 to 10 mum in thickness and 20 to 100 mum in width. The sample has two illumination marks on the top surface for strain measurement. The uniaxial tension test setup has been built to accommodate requirements such as sample handling, sample alignment, and friction elimination. Stress is measured using a commercial load cell. Strain is measured by laser interferometry. All the components are connected to a data acquisition board and controlled by a personal computer. Measured Young's moduli in three directions agree well with the reference values and verify the reliability of the setup and measurement procedure. The measured fracture strength is 0.6 GPa to 1.2 GPa, depending on sample preparation methods and loading directions. Preliminary work for fracture toughness measurements using a sharp initial crack is also presented. Future works include further investigation of fracture surfaces, fracture toughness measurement using crack opening criteria, and improvement of the testing apparatus.

  19. Proper Image Subtraction—Optimal Transient Detection, Photometry, and Hypothesis Testing

    NASA Astrophysics Data System (ADS)

    Zackay, Barak; Ofek, Eran O.; Gal-Yam, Avishay

    2016-10-01

    Transient detection and flux measurement via image subtraction stand at the base of time domain astronomy. Due to the varying seeing conditions, the image subtraction process is non-trivial, and existing solutions suffer from a variety of problems. Starting from basic statistical principles, we develop the optimal statistic for transient detection, flux measurement, and any image-difference hypothesis testing. We derive a closed-form statistic that: (1) is mathematically proven to be the optimal transient detection statistic in the limit of background-dominated noise, (2) is numerically stable, (3) for accurately registered, adequately sampled images, does not leave subtraction or deconvolution artifacts, (4) allows automatic transient detection to the theoretical sensitivity limit by providing credible detection significance, (5) has uncorrelated white noise, (6) is a sufficient statistic for any further statistical test on the difference image, and, in particular, allows us to distinguish particle hits and other image artifacts from real transients, (7) is symmetric to the exchange of the new and reference images, (8) is at least an order of magnitude faster to compute than some popular methods, and (9) is straightforward to implement. Furthermore, we present extensions of this method that make it resilient to registration errors, color-refraction errors, and any noise source that can be modeled. In addition, we show that the optimal way to prepare a reference image is the proper image coaddition presented in Zackay & Ofek. We demonstrate this method on simulated data and real observations from the PTF data release 2. We provide an implementation of this algorithm in MATLAB and Python.

  20. THEORETICAL ANALYSIS OF THE TRANSIENT PRESSURE RESPONSE FROM A CONSTANT FLOW RATE HYDRAULIC CONDUCTIVITY TEST.

    USGS Publications Warehouse

    Morin, Roger H.; Olsen, Harold W.

    1987-01-01

    Incorporating a flow pump into a conventional triaxial laboratory system allows fluid to be supplied to or withdrawn from the base of a sediment sample at small and constant rates. An initial transient record of hydraulic head versus time is observed which eventually stabilizes to a constant steady state gradient across the sample; values of hydraulic conductivity can subsequently be determined from Darcy's law. In this paper, analytical methods are presented for determining values of specific storage and hydraulic conductivity from the initial transient phase of such a constant flow rate test. These methods are based on a diffusion equation involving pore pressure and are analogous to those used to describe the soil consolidation process and also to interpret aquifer properties from pumping tests.

  1. Improving Single Event Effects Testing Through Software

    NASA Technical Reports Server (NTRS)

    Banker, M. W.

    2011-01-01

    Radiation encountered in space environments can be damaging to microelectronics and potentially cause spacecraft failure. Single event effects (SEE) are a type of radiation effect that occur when an ion strikes a device. Single event gate rupture (SEGR) is a type of SEE that can cause failure in power transistors. Unlike other SEE rates in which a constant linear energy transfer (LET) can be used, SEGR rates sometimes require a non-uniform LET to be used to be accurate. A recent analysis shows that SEGR rates are most easily calculated when the environment is described as a stopping rate per unit volume for each ion species. Stopping rates in silicon for pertinent ions were calculated using the Stopping and Range of Ions in Matter (SRIM) software and CREME-MC software. A reference table was generated and can be used by others to calculate SEGR rates for a candidate device. Additionally, lasers can be used to simulate SEEs, providing more control and information at lower cost than heavy ion testing. The electron/hole pair generation rate from a laser pulse in a semiconductor can be related to the LET of an ion. MATLAB was used to generate a plot to easily make this comparison.

  2. Quantifying Transient 3D Dynamical Phenomena of Single mRNA Particles in Live Yeast Cell Measurements

    PubMed Central

    Calderon, Christopher P.; Thompson, Michael A.; Casolari, Jason M.; Paffenroth, Randy C.; Moerner, W. E.

    2013-01-01

    Single-particle tracking (SPT) has been extensively used to obtain information about diffusion and directed motion in a wide range of biological applications. Recently, new methods have appeared for obtaining precise (10s of nm) spatial information in three dimensions (3D) with high temporal resolution (measurements obtained every 4ms), which promise to more accurately sense the true dynamical behavior in the natural 3D cellular environment. Despite the quantitative 3D tracking information, the range of mathematical methods for extracting information about the underlying system has been limited mostly to mean-squared displacement analysis and other techniques not accounting for complex 3D kinetic interactions. There is a great need for new analysis tools aiming to more fully extract the biological information content from in vivo SPT measurements. High-resolution SPT experimental data has enormous potential to objectively scrutinize various proposed mechanistic schemes arising from theoretical biophysics and cell biology. At the same time, methods for rigorously checking the statistical consistency of both model assumptions and estimated parameters against observed experimental data (i.e. goodness-of-fit tests) have not received great attention. We demonstrate methods enabling (1) estimation of the parameters of 3D stochastic differential equation (SDE) models of the underlying dynamics given only one trajectory; and (2) construction of hypothesis tests checking the consistency of the fitted model with the observed trajectory so that extracted parameters are not over-interpreted (the tools are applicable to linear or nonlinear SDEs calibrated from non-stationary time series data). The approach is demonstrated on high-resolution 3D trajectories of single ARG3 mRNA particles in yeast cells in order to show the power of the methods in detecting signatures of transient directed transport. The methods presented are generally relevant to a wide variety of 2D and 3D SPT

  3. Compilation of Quality Assurance Documentation for Analyses Performed for the Resumption of Transient Testing Environmental Assessment

    SciTech Connect

    Annette L. Schafer; A. Jeffrey Sondrup

    2013-11-01

    This is a companion document to the analyses performed in support of the environmental assessment for the Resumption of Transient Fuels and Materials Testing. It is provided to allow transparency of the supporting calculations. It provides computer code input and output. The basis for the calculations is documented separately in INL (2013) and is referenced, as appropriate. Spreadsheets used to manipulate the code output are not provided.

  4. 49 CFR 232.305 - Single car air brake tests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Single car air brake tests. 232.305 Section 232... car air brake tests. (a) Single car air brake tests shall be performed by a qualified person in... single car air brake test on a car when: (1) A car has its brakes cut-out or inoperative when...

  5. 49 CFR 232.305 - Single car air brake tests.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Single car air brake tests. 232.305 Section 232... car air brake tests. (a) Single car air brake tests shall be performed by a qualified person in... single car air brake test on a car when: (1) A car has its brakes cut-out or inoperative when...

  6. 49 CFR 232.305 - Single car air brake tests.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Single car air brake tests. 232.305 Section 232... car air brake tests. (a) Single car air brake tests shall be performed by a qualified person in... single car air brake test on a car when: (1) A car has its brakes cut-out or inoperative when...

  7. 49 CFR 232.305 - Single car air brake tests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Single car air brake tests. 232.305 Section 232... car air brake tests. (a) Single car air brake tests shall be performed by a qualified person in... single car air brake test on a car when: (1) A car has its brakes cut-out or inoperative when...

  8. 49 CFR 232.305 - Single car air brake tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Single car air brake tests. 232.305 Section 232... car air brake tests. (a) Single car air brake tests shall be performed by a qualified person in... single car air brake test on a car when: (1) A car has its brakes cut-out or inoperative when...

  9. Single Event Transients Induced by Picosecond Pulsed X-Ray Absorption in III-V Heterojunction Transistors

    SciTech Connect

    Cardoza, David M; LaLumondiere, Stephen D; Tockstein, Michael A; Witczak, Steven C; Sin, Yongkun; Foran, Brendan J; Lotshaw, William T; Moss, Steven C

    2013-01-17

    We perform measurements which show that focused, picosecond pulses of x-rays can be used to generate single event transients (SET) in a GaAs heterostructure field effect transistor (HFET) and a GaN high electron mobility transistor. X-ray pulses with photon energies of 8, 10 and 12 keV from the Advanced Photon Source at Argonne National Laboratory were used to excite transients. SETs are observed when x-ray pulses are incident upon metal layers above sensitive areas on the transistors. We use focused ion beam (FIB) cross-sectioning and scanning transmission electron microscopy energy dispersive x-ray spectroscopy (STEM-EDXS) to determine the compositional structure of the devices. We present a first order analysis of energy deposition in the devices and correlate it to the transient response to make preliminary interpretations of the results. We compare the x-ray transients from the GaAs HFET with transients generated by 750 nm and 870 nm femtosecond laser pulses. We also present results on the total dose susceptibility of the GaN HEMTs.

  10. Nonlinear transient wave excitation as a new tool in model testing

    SciTech Connect

    Clauss, G.F.; Kuehnlein, W.L.

    1996-12-31

    Short extension transient waves with tailor-made spectra are extremely efficient for model testing. For small water elevations a linear description of the wave field is satisfactory. With higher transient wave trains, however, the linear description becomes increasingly inaccurate, and a new numerical technique must be developed. Such a new method is based on the fact that short and high wave groups with strong nonlinear characteristics evolve from long and low wave groups, which are characterized by linear principles. As the total energy of the transient wave is invariant during its metamorphosis, the initial linear Fourier spectrum is selected as the backbone of wave information or as the primordial cell from which all nonlinearities are hatched. Based on the initial Fourier spectrum which is the core of the wave information operator the shape variation of the linear transient wave train during propagation is calculated. At selected positions the nonlinear expansion is accomplished by solving the mutually dependent particle motion equations in time domain. The proposed new method uses a numerical nonlinear description of transient wave trains as a function of time or space for any fixed or moving reference point. At its primordial state it is based on a linear superposition of wave information which is complemented by an expanded velocity potential to calculate nonlinear surface elevations, particle motions, velocities, and accelerations. After the nonlinear wave trains converge and pass the concentration point only to diverge and fade away as long, low and linear wave groups, the primordial linear Fourier spectrum can be found again at the end of the development. This step can be used to monitor the transformation. Wave energy spectra and the shape of the wave train can be designed with special regard to the proposed task. Based on these data the entire wave field can be determined.

  11. Testing the ontogenetic base for the transient model of inflorescence development

    PubMed Central

    Bull-Hereñu, Kester; Claßen-Bockhoff, Regine

    2013-01-01

    Backgrounds and Aims Current research in plant science has concentrated on revealing ontogenetic processes of key attributes in plant evolution. One recently discussed model is the ‘transient model’ successful in explaining some types of inflorescence architectures based on two main principles: the decline of the so called ‘vegetativeness’ (veg) factor and the transient nature of apical meristems in developing inflorescences. This study examines whether both principles find a concrete ontogenetic correlate in inflorescence development. Methods To test the ontogenetic base of veg decline and the transient character of apical meristems the ontogeny of meristematic size in developing inflorescences was investigated under scanning electron microscopy. Early and late inflorescence meristems were measured and compared during inflorescence development in 13 eudicot species from 11 families. Key Results The initial size of the inflorescence meristem in closed inflorescences correlates with the number of nodes in the mature inflorescence. Conjunct compound inflorescences (panicles) show a constant decrease of meristematic size from early to late inflorescence meristems, while disjunct compound inflorescences present an enlargement by merging from early inflorescence meristems to late inflorescence meristems, implying a qualitative change of the apical meristems during ontogeny. Conclusions Partial confirmation was found for the transient model for inflorescence architecture in the ontogeny: the initial size of the apical meristem in closed inflorescences is consistent with the postulated veg decline mechanism regulating the size of the inflorescence. However, the observed biphasic kinetics of the development of the apical meristem in compound racemes offers the primary explanation for their disjunct morphology, contrary to the putative exclusive transient mechanism in lateral axes as expected by the model. PMID:23425784

  12. An infrastructure for accurate characterization of single-event transients in digital circuits☆

    PubMed Central

    Savulimedu Veeravalli, Varadan; Polzer, Thomas; Schmid, Ulrich; Steininger, Andreas; Hofbauer, Michael; Schweiger, Kurt; Dietrich, Horst; Schneider-Hornstein, Kerstin; Zimmermann, Horst; Voss, Kay-Obbe; Merk, Bruno; Hajek, Michael

    2013-01-01

    We present the architecture and a detailed pre-fabrication analysis of a digital measurement ASIC facilitating long-term irradiation experiments of basic asynchronous circuits, which also demonstrates the suitability of the general approach for obtaining accurate radiation failure models developed in our FATAL project. Our ASIC design combines radiation targets like Muller C-elements and elastic pipelines as well as standard combinational gates and flip-flops with an elaborate on-chip measurement infrastructure. Major architectural challenges result from the fact that the latter must operate reliably under the same radiation conditions the target circuits are exposed to, without wasting precious die area for a rad-hard design. A measurement architecture based on multiple non-rad-hard counters is used, which we show to be resilient against double faults, as well as many triple and even higher-multiplicity faults. The design evaluation is done by means of comprehensive fault injection experiments, which are based on detailed Spice models of the target circuits in conjunction with a standard double-exponential current injection model for single-event transients (SET). To be as accurate as possible, the parameters of this current model have been aligned with results obtained from 3D device simulation models, which have in turn been validated and calibrated using micro-beam radiation experiments at the GSI in Darmstadt, Germany. For the latter, target circuits instrumented with high-speed sense amplifiers have been used for analog SET recording. Together with a probabilistic analysis of the sustainable particle flow rates, based on a detailed area analysis and experimental cross-section data, we can conclude that the proposed architecture will indeed sustain significant target hit rates, without exceeding the resilience bound of the measurement infrastructure. PMID:24748694

  13. An infrastructure for accurate characterization of single-event transients in digital circuits.

    PubMed

    Savulimedu Veeravalli, Varadan; Polzer, Thomas; Schmid, Ulrich; Steininger, Andreas; Hofbauer, Michael; Schweiger, Kurt; Dietrich, Horst; Schneider-Hornstein, Kerstin; Zimmermann, Horst; Voss, Kay-Obbe; Merk, Bruno; Hajek, Michael

    2013-11-01

    We present the architecture and a detailed pre-fabrication analysis of a digital measurement ASIC facilitating long-term irradiation experiments of basic asynchronous circuits, which also demonstrates the suitability of the general approach for obtaining accurate radiation failure models developed in our FATAL project. Our ASIC design combines radiation targets like Muller C-elements and elastic pipelines as well as standard combinational gates and flip-flops with an elaborate on-chip measurement infrastructure. Major architectural challenges result from the fact that the latter must operate reliably under the same radiation conditions the target circuits are exposed to, without wasting precious die area for a rad-hard design. A measurement architecture based on multiple non-rad-hard counters is used, which we show to be resilient against double faults, as well as many triple and even higher-multiplicity faults. The design evaluation is done by means of comprehensive fault injection experiments, which are based on detailed Spice models of the target circuits in conjunction with a standard double-exponential current injection model for single-event transients (SET). To be as accurate as possible, the parameters of this current model have been aligned with results obtained from 3D device simulation models, which have in turn been validated and calibrated using micro-beam radiation experiments at the GSI in Darmstadt, Germany. For the latter, target circuits instrumented with high-speed sense amplifiers have been used for analog SET recording. Together with a probabilistic analysis of the sustainable particle flow rates, based on a detailed area analysis and experimental cross-section data, we can conclude that the proposed architecture will indeed sustain significant target hit rates, without exceeding the resilience bound of the measurement infrastructure.

  14. Transient Pressure Test Article (TPTA) 1.1 and 1.1A, volume 1

    NASA Technical Reports Server (NTRS)

    Rebells, Clarence A.

    1988-01-01

    This final test report presents the results obtained during the static hot firing and cold-gas high Q tests of the first Transient Pressure Test Article (TPTA) 1.1. The TPTA consisted of field test joints A and B, which were the original RSRM J-insulation configuration, with a metal capture feature. It also consisted of a flight configuration nozzle-to-case test joint (Joint D) with shorter vent slots. Fluorocarbon O-rings were used in all the test joints. The purpose of the TPTA tests is to evaluate and characterize the RSMR field and nozzle-to-case joints under the influence of ignition and strut loads during liftoff anf high Q. All objectives of the cold-gas high Q (TPTA 1.1A) test were met and all measurements were close to predicted values. During the static hot-firing test (TPTA 1.1), the motor was inadvertently plugged by the quench injector plug, making it a more severe test, although no strut loads were applied. The motor was depressurized after approximately 11 min using an auxiliary system, and no anomalies were noted. In the static hot-firing test, pressure was incident on the insulation and the test joint gaps were within the predicted range. During the static hot-firing test, no strut loads were applied because the loading system malfunctioned. For this test, all measurements were within range of similar tests performed without strut loads.

  15. Transient Thermal Testing and Analysis of a Thermally Insulating Structural Sandwich Panel

    NASA Technical Reports Server (NTRS)

    Blosser, Max L.; Daryabeigi, Kamran; Bird, Richard K.; Knutson, Jeffrey R.

    2015-01-01

    A core configuration was devised for a thermally insulating structural sandwich panel. Two titanium prototype panels were constructed to illustrate the proposed sandwich panel geometry. The core of one of the titanium panels was filled with Saffil(trademark) alumina fibrous insulation and the panel was tested in a series of transient thermal tests. Finite element analysis was used to predict the thermal response of the panel using one- and two-dimensional models. Excellent agreement was obtained between predicted and measured temperature histories.

  16. Evaluation of the Transient Hydrologic Source Term for the Cambric Underground Nuclear Test at Frenchman Flat, Nevada test Site

    SciTech Connect

    Carle, S F; Maxwell, R M; Pawloski, G A; Shumaker, D E; Tompson, A B; Zavarin, M

    2006-12-12

    The objective of Phase II HST work is to develop a better understanding of the evolution of the HST for 1,000 years at the CAMBRIC underground nuclear test site in Frenchman Flat at the NTS. This work provides a better understanding of activities as they actually occurred, incorporates improvements based on recent data acquisition, and provides a basis to use the CAMBRIC site for model validation and monitoring activities as required by the UGTA Project. CAMBRIC was the only test in Frenchman Flat detonated under the water table and best represents a fully saturated environment. These simulations are part of a broad Phase II Frenchman Flat Corrective Action Unit (CAU) flow and transport modeling effort being conducted by the Department of Energy (DOE) Underground Test Area (UGTA) Project. HST simulations provide, either directly or indirectly, the source term used in the CAU model to calculate a contaminant boundary. Work described in this report augments Phase I HST calculations at CAMBRIC conducted by Tompson et al. (1999) and Pawloski et al. (2001). Phase II HST calculations have been organized to calculate source terms under two scenarios: (1) A representation of the transient flow and radionuclide release behavior at the CAMBRIC site that is more specific than Tompson et al. (1999). This model reflects the influence of the background hydraulic gradient, residual test heat, pumping experiment, and ditch recharge, and takes into account improved data sources and modeling approaches developed since the previous efforts. Collectively, this approach will be referred to as the transient CAMBRIC source term. This report describes the development of the transient CAMBRIC HST. (2) A generic release model made under steady-state flow conditions, in the absence of any transient effects, at the same site with the same radiologic source term. This model is for use in the development of simpler release models for the other nine underground test sites in the Frenchman Flat

  17. 49 CFR 238.311 - Single car test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Single car test. 238.311 Section 238.311... Requirements for Tier I Passenger Equipment § 238.311 Single car test. (a) Except for self-propelled passenger cars, single car tests of all passenger cars and all unpowered vehicles used in passenger trains...

  18. 49 CFR 238.311 - Single car test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Single car test. 238.311 Section 238.311... Requirements for Tier I Passenger Equipment § 238.311 Single car test. (a) Except for self-propelled passenger cars, single car tests of all passenger cars and all unpowered vehicles used in passenger trains...

  19. 49 CFR 238.311 - Single car test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Single car test. 238.311 Section 238.311... Requirements for Tier I Passenger Equipment § 238.311 Single car test. (a) Except for self-propelled passenger cars, single car tests of all passenger cars and all unpowered vehicles used in passenger trains...

  20. 49 CFR 238.311 - Single car test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Single car test. 238.311 Section 238.311... Requirements for Tier I Passenger Equipment § 238.311 Single car test. (a) Except for self-propelled passenger cars, single car tests of all passenger cars and all unpowered vehicles used in passenger trains...

  1. 49 CFR 238.311 - Single car test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Single car test. 238.311 Section 238.311... Requirements for Tier I Passenger Equipment § 238.311 Single car test. (a) Except for self-propelled passenger cars, single car tests of all passenger cars and all unpowered vehicles used in passenger trains...

  2. Single Event Effects (SEE) Testing of Embedded DSP Cores within Microsemi RTAX4000D Field Programmable Gate Array (FPGA) Devices

    NASA Technical Reports Server (NTRS)

    Perez, Christopher E.; Berg, Melanie D.; Friendlich, Mark R.

    2011-01-01

    Motivation for this work is: (1) Accurately characterize digital signal processor (DSP) core single-event effect (SEE) behavior (2) Test DSP cores across a large frequency range and across various input conditions (3) Isolate SEE analysis to DSP cores alone (4) Interpret SEE analysis in terms of single-event upsets (SEUs) and single-event transients (SETs) (5) Provide flight missions with accurate estimate of DSP core error rates and error signatures.

  3. Transient analysis of distribution class Adaptive Var Compensators: Simulation and field test results

    SciTech Connect

    Kagalwala, R.A.; Venkata, S.S.; El-Sharkawi, M.A.; Butler, N.G.; Van Leuven, A.; Rodriguez, A.P.; Kerszenbaum, I.; Smith, D.

    1995-04-01

    Simulation studies are performed to analyze the transient behavior of the Adaptive Var Compensator (AVC), a power electronic device installed at the distribution level, during its design, installation and field testing stages. The simulation model includes detailed models for power apparatus, power semiconductor devices and low signal level electronics. Hence, by using this model, a wide range of simulation studies which contribute towards the development of the AVC and its effectiveness in the field can all be performed on the same platform. A new power electronics simulator called SABER has proven to be very effective for this study because of its model-independent structure and extensive library that covers various disciplines of engineering. The simulation studies are aimed at gaining a better understanding of the interaction between the AVC and the distribution system. They cover a range of phenomena such as switching transients due to mechanical capacitor bank closing, fast transients due to reverse recovery of the power diodes of the AVC, power system harmonics and voltage flicker problem. This paper also briefly describes the criteria for selection of the simulation tool and the models developed.

  4. Predicting the Reliability of Brittle Material Structures Subjected to Transient Proof Test and Service Loading

    NASA Astrophysics Data System (ADS)

    Nemeth, Noel N.; Jadaan, Osama M.; Palfi, Tamas; Baker, Eric H.

    Brittle materials today are being used, or considered, for a wide variety of high tech applications that operate in harsh environments, including static and rotating turbine parts, thermal protection systems, dental prosthetics, fuel cells, oxygen transport membranes, radomes, and MEMS. Designing brittle material components to sustain repeated load without fracturing while using the minimum amount of material requires the use of a probabilistic design methodology. The NASA CARES/Life 1 (Ceramic Analysis and Reliability Evaluation of Structure/Life) code provides a general-purpose analysis tool that predicts the probability of failure of a ceramic component as a function of its time in service. This capability includes predicting the time-dependent failure probability of ceramic components against catastrophic rupture when subjected to transient thermomechanical loads (including cyclic loads). The developed methodology allows for changes in material response that can occur with temperature or time (i.e. changing fatigue and Weibull parameters with temperature or time). For this article an overview of the transient reliability methodology and how this methodology is extended to account for proof testing is described. The CARES/Life code has been modified to have the ability to interface with commercially available finite element analysis (FEA) codes executed for transient load histories. Examples are provided to demonstrate the features of the methodology as implemented in the CARES/Life program.

  5. Comparison of Single Event Transients Generated by Short Pulsed X-Rays, Lasers and Heavy Ions

    SciTech Connect

    Cardoza, David; LaLumondiere, Stephen D.; Tockstein, Michael A.; Brewe, Dale L.; Wells, Nathan P.; Koga, Rokutaro; Gaab, K. M.; Lotshaw, William T.; Moss, Steven C.

    2014-12-01

    We report an experimental study of the transients generated by pulsed x-rays, heavy ions, and different laser wavelengths in a Si p-i-n photodiode. We compare the charge collected by all of the excitation methods to determine the equivalent LET for pulsed x-rays relative to heavy ions. Our comparisons show that pulsed x-rays from synchrotron sources can generate a large range of equivalent LET and generate transients similar to those excited by laser pulses and heavy ion strikes. We also look at how the pulse width of the transients changes for the different excitation methods. We show that the charge collected with pulsed x-rays is greater than expected as the x-ray photon energy increases. Combined with their capability of focusing to small spot sizes and of penetrating metallization, pulsed x-rays are a promising new tool for high resolution screening of SEE susceptibility

  6. Discussions On Worst-Case Test Condition For Single Event Burnout

    NASA Astrophysics Data System (ADS)

    Liu, Sandra; Zafrani, Max; Sherman, Phillip

    2011-10-01

    This paper discusses the failure characteristics of single- event burnout (SEB) on power MOSFETs based on analyzing the quasi-stationary avalanche simulation curves. The analyses show the worst-case test condition for SEB would be using the ion that has the highest mass that would result in the highest transient current due to charge deposition and displacement damage. The analyses also show it is possible to build power MOSFETs that will not exhibit SEB even when tested with the heaviest ion, which have been verified by heavy ion test data on SEB sensitive and SEB immune devices.

  7. Testing the single-state dominance hypothesis

    SciTech Connect

    Álvarez-Rodríguez, R.; Moreno, O.; Moya de Guerra, E.; Sarriguren, P.; Šimkovic, F.; Faessler, A.

    2013-12-30

    We present a theoretical analysis of the single-state dominance hypothesis for the two-neutrino double-beta decay process. The theoretical framework is a proton-neutron QRPA based on a deformed Hartree-Fock mean field with BCS pairing correlations. We focus on the decays of {sup 100}Mo, {sup 116}Cd and {sup 128}Te. We do not find clear evidences for single-state dominance within the present approach.

  8. Testing IH Instrumentation: Analysis of 1996-1998 Tank Ventilation Data in Terms of Characterizing a Transient Release

    SciTech Connect

    Droppo, James G.

    2004-07-01

    An analysis is conducted of the 1996-1998 Hanford tank ventilation studies of average ventilation rates to help define characteristics of shorter term releases. This effort is being conducted as part of the design of tests of Industrial Hygiene’s (IH) instrumentation ability to detect transient airborne plumes from tanks using current deployment strategies for tank operations. This analysis has improved our understanding of the variability of hourly average tank ventilation processes. However, the analysis was unable to discern the relative importance of emissions due to continuous releases and short-duration bursts of material. The key findings are as follows: 1. The ventilation of relatively well-sealed, passively ventilated tanks appears to be driven by a combination of pressure, buoyancy, and wind influences. The results of a best-fit analysis conducted with a single data set provide information on the hourly emission variability that IH instrumentation will need to detect. 2. Tank ventilation rates and tank emission rates are not the same. The studies found that the measured infiltration rates for a single tank are often a complex function of air exchanges between tanks and air exchanges with outdoor air. This situation greatly limits the usefulness of the ventilation data in defining vapor emission rates. 3. There is no evidence in the data to discern if the routine tank vapor releases occur over a short time (i.e., a puff) or over an extended time (i.e., continuous releases). Based on this analysis of the tank ventilation studies, it is also noted that 1) the hourly averaged emission peaks from the relatively well-sealed passively-vented tanks (such as U-103) are not a simple function of one meteorological parameter – but the peaks often are the result of the coincidence of temporal maximums in pressure, temperature, and wind influences and 2) a mechanistic combination modeling approach and/or field studies may be necessary to understand the short

  9. Stochastic expression of a multiple antibiotic resistance activator confers transient resistance in single cells.

    PubMed

    El Meouche, Imane; Siu, Yik; Dunlop, Mary J

    2016-01-13

    Transient resistance can allow microorganisms to temporarily survive lethal concentrations of antibiotics. This can be accomplished through stochastic mechanisms, where individual cells within a population display diverse phenotypes to hedge against the appearance of an antibiotic. To date, research on transient stochastic resistance has focused primarily on mechanisms where a subpopulation of cells enters a dormant, drug-tolerant state. However, a fundamental question is whether stochastic gene expression can also generate variable resistance levels among growing cells in a population. We hypothesized that stochastic expression of antibiotic-inducible resistance mechanisms might play such a role. To investigate this, we focused on a prototypical example of such a system: the multiple antibiotic resistance activator MarA. Previous studies have shown that induction of MarA can lead to a multidrug resistant phenotype at the population level. We asked whether MarA expression also has a stochastic component, even when uninduced. Time lapse microscopy showed that isogenic cells express heterogeneous, dynamic levels of MarA, which were correlated with transient antibiotic survival. This finding has important clinical implications, as stochastic expression of resistance genes may be widespread, allowing populations to hedge against the sudden appearance of an antibiotic.

  10. Theoretical Evaluation of the Transient Response of Constant Head and Constant Flow-Rate Permeability Tests

    USGS Publications Warehouse

    Zhang, M.; Takahashi, M.; Morin, R.H.; Esaki, T.

    1998-01-01

    A theoretical analysis is presented that compares the response characteristics of the constant head and the constant flowrate (flow pump) laboratory techniques for quantifying the hydraulic properties of geologic materials having permeabilities less than 10-10 m/s. Rigorous analytical solutions that describe the transient distributions of hydraulic gradient within a specimen are developed, and equations are derived for each method. Expressions simulating the inflow and outflow rates across the specimen boundaries during a constant-head permeability test are also presented. These solutions illustrate the advantages and disadvantages of each method, including insights into measurement accuracy and the validity of using Darcy's law under certain conditions. The resulting observations offer practical considerations in the selection of an appropriate laboratory test method for the reliable measurement of permeability in low-permeability geologic materials.

  11. Single Event Testing on Complex Devices: Test Like You Fly versus Test-Specific Design Structures

    NASA Technical Reports Server (NTRS)

    Berg, Melanie; LaBel, Kenneth A.

    2014-01-01

    We present a framework for evaluating complex digital systems targeted for harsh radiation environments such as space. Focus is limited to analyzing the single event upset (SEU) susceptibility of designs implemented inside Field Programmable Gate Array (FPGA) devices. Tradeoffs are provided between application-specific versus test-specific test structures.

  12. Joint tests at INL and CEA of a transient hot wire needle probe for in-pile thermal conductivity measurement

    SciTech Connect

    Daw, J.E.; Knudson, D.L.; Villard, J.F.; Liothin, J.; Destouches, C.; Rempe, J.L.; Matheron, P.; Lambert, T.

    2015-07-01

    Thermal conductivity is a key property that must be known for proper design, testing, and deployment of new fuels and structural materials in nuclear reactors. Thermal conductivity is highly dependent on the physical structure, chemical composition, and the state of the material. Typically, thermal conductivity changes that occur during irradiation are currently measured out-of-pile using a 'cook and look' approach. But repeatedly removing samples from a test reactor to make measurements is expensive, has the potential to disturb phenomena of interest, and only provides understanding of the sample's end state when each measurement is made. There are also limited thermo-physical property data available for advanced fuels; and such data are needed for simulation codes, the development of next generation reactors, and advanced fuels for existing nuclear plants. Being able to quickly characterize fuel thermal conductivity during irradiation can improve the fidelity of data, reduce costs of post-irradiation examinations, increase understanding of how fuels behave under irradiation, and confirm or improve existing thermal conductivity measurement techniques. This paper discusses efforts to develop and evaluate an innovative in-pile thermal conductivity sensor based on the transient hot wire thermal conductivity method (THWM), using a single needle probe (NP) containing a line heat source and thermocouple embedded in the fuel. The sensor that has been designed and manufactured by the Idaho National Laboratory (INL) includes a unique combination of materials, geometry, and fabrication techniques that make the hot wire method suitable for in-pile applications. In particular, efforts were made to minimize the influence of the sensor and maximize fuel hot-wire heating. The probe has a thermocouple-like construction with high temperature resistant materials that remain ductile while resisting transmutation and materials interactions. THWM-NP prototypes were fabricated for both

  13. Transient state imaging of live cells using single plane illumination and arbitrary duty cycle excitation pulse trains.

    PubMed

    Mücksch, Jonas; Spielmann, Thiemo; Sisamakis, Evangelos; Widengren, Jerker

    2015-05-01

    We demonstrate the applicability of Single Plane Illumination Microscopy to Transient State Imaging (TRAST), offering sensitive microenvironmental information together with optical sectioning and reduced overall excitation light exposure of the specimen. The concept is verified by showing that transition rates can be determined accurately for free dye in solution and that fluorophore transition rates can be resolved pixel-wise in live cells. Furthermore, we derive a new theoretical framework for analyzing TRAST data acquired with arbitrary duty cycle pulse trains. By this analysis it is possible to reduce the overall measurement time and thereby enhance the frame rates in TRAST imaging.

  14. Modeling from Local to Subsystem Level Effects in Analog and Digital Circuits Due to Space Induced Single Event Transients

    NASA Technical Reports Server (NTRS)

    Perez, Reinaldo J.

    2011-01-01

    Single Event Transients in analog and digital electronics from space generated high energetic nuclear particles can disrupt either temporarily and sometimes permanently the functionality and performance of electronics in space vehicles. This work first provides some insights into the modeling of SET in electronic circuits that can be used in SPICE-like simulators. The work is then directed to present methodologies, one of which was developed by this author, for the assessment of SET at different levels of integration in electronics, from the circuit level to the subsystem level.

  15. Deep level transient spectroscopy studies of n-type ZnO single crystals grown by different techniques.

    PubMed

    Scheffler, L; Kolkovsky, Vl; Lavrov, E V; Weber, J

    2011-08-24

    In the present study single-crystalline ZnO samples grown from the vapor phase, the melt, and a high-temperature aqueous solution (hydrothermal growth) are investigated before and after hydrogen plasma treatments, by means of deep level transient spectroscopy (DLTS) and high-resolution Laplace DLTS. Dominant DLTS peaks are found to appear in the range of 120-350 K for all materials. The DLTS spectra depend on the procedure of growth of the ZnO. The thermal stabilities of the defects in an oxygen atmosphere and in an oxygen-lean atmosphere are analyzed. The origin of the DLTS peaks is discussed.

  16. Transverse spatial coherence of a transient nickellike silver soft-x-ray laser pumped by a single picosecond laser pulse.

    PubMed

    Lucianetti, A; Janulewicz, K A; Kroemer, R; Priebe, G; Tümmler, J; Sandner, W; Nickles, P V; Redkorechev, V I

    2004-04-15

    The degree of spatial coherence in the direction perpendicular to the target surface is reported for a transient nickellike silver x-ray laser at 13.9 nm. An x-ray laser plasma column was produced by irradiating a slab silver target with a single shaped picosecond laser pulse with energy less than 3 J. Young's double-slit method was applied to measure the fringe visibility as a function of the slit separation for different target lengths. The diameter of the equivalent incoherent source and the coherence radius of the output radiation were determined as well.

  17. 40 CFR 1039.510 - Which duty cycles do I use for transient testing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION... consists of an initial run through the transient duty cycle from a cold start, 20 minutes with no engine operation, then a final run through the same transient duty cycle. Calculate the official transient...

  18. 40 CFR 1039.510 - Which duty cycles do I use for transient testing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION... consists of an initial run through the transient duty cycle from a cold start, 20 minutes with no engine operation, then a final run through the same transient duty cycle. Calculate the official transient...

  19. Use of ruthenium dyes for subnanosecond detector fidelity testing in real time transient absorption.

    PubMed

    Byrdin, Martin; Thiagarajan, Viruthachalam; Villette, Sandrine; Espagne, Agathe; Brettel, Klaus

    2009-04-01

    Transient absorption spectroscopy is a powerful tool for the study of photoreactions on time scales from femtoseconds to seconds. Typically, reactions slower than approximately 1 ns are recorded by the "classical" technique; the reaction is triggered by an excitation flash, and absorption changes accompanying the reaction are recorded in real time using a continuous monitoring light beam and a detection system with sufficiently fast response. The pico- and femtosecond region can be accessed by the more recent "pump-probe" technique, which circumvents the difficulties of real time detection on a subnanosecond time scale. This is paid for by accumulation of an excessively large number of shots to sample the reaction kinetics. Hence, it is of interest to extend the classical real time technique as far as possible to the subnanosecond range. In order to identify and minimize detection artifacts common on a subnanosecond scale, like overshoot, ringing, and signal reflections, rigorous testing is required of how the detection system responds to fast changes of the monitoring light intensity. Here, we introduce a novel method to create standard signals for detector fidelity testing on a time scale from a few picoseconds to tens of nanoseconds. The signals result from polarized measurements of absorption changes upon excitation of ruthenium complexes {[Ru(bpy)(3)](2+) and a less symmetric derivative} by a short laser flash. Two types of signals can be created depending on the polarization of the monitoring light with respect to that of the excitation flash: a fast steplike bleaching at magic angle and a monoexponentially decaying bleaching for parallel polarizations. The lifetime of the decay can be easily varied via temperature and viscosity of the solvent. The method is applied to test the performance of a newly developed real time transient absorption setup with 300 ps time resolution and high sensitivity.

  20. Use of ruthenium dyes for subnanosecond detector fidelity testing in real time transient absorption

    SciTech Connect

    Byrdin, Martin; Thiagarajan, Viruthachalam; Villette, Sandrine; Espagne, Agathe; Brettel, Klaus

    2009-04-15

    Transient absorption spectroscopy is a powerful tool for the study of photoreactions on time scales from femtoseconds to seconds. Typically, reactions slower than {approx}1 ns are recorded by the ''classical'' technique; the reaction is triggered by an excitation flash, and absorption changes accompanying the reaction are recorded in real time using a continuous monitoring light beam and a detection system with sufficiently fast response. The pico- and femtosecond region can be accessed by the more recent ''pump-probe'' technique, which circumvents the difficulties of real time detection on a subnanosecond time scale. This is paid for by accumulation of an excessively large number of shots to sample the reaction kinetics. Hence, it is of interest to extend the classical real time technique as far as possible to the subnanosecond range. In order to identify and minimize detection artifacts common on a subnanosecond scale, like overshoot, ringing, and signal reflections, rigorous testing is required of how the detection system responds to fast changes of the monitoring light intensity. Here, we introduce a novel method to create standard signals for detector fidelity testing on a time scale from a few picoseconds to tens of nanoseconds. The signals result from polarized measurements of absorption changes upon excitation of ruthenium complexes {l_brace}[Ru(bpy){sub 3}]{sup 2+} and a less symmetric derivative{r_brace} by a short laser flash. Two types of signals can be created depending on the polarization of the monitoring light with respect to that of the excitation flash: a fast steplike bleaching at magic angle and a monoexponentially decaying bleaching for parallel polarizations. The lifetime of the decay can be easily varied via temperature and viscosity of the solvent. The method is applied to test the performance of a newly developed real time transient absorption setup with 300 ps time resolution and high sensitivity.

  1. Use of ruthenium dyes for subnanosecond detector fidelity testing in real time transient absorption

    NASA Astrophysics Data System (ADS)

    Byrdin, Martin; Thiagarajan, Viruthachalam; Villette, Sandrine; Espagne, Agathe; Brettel, Klaus

    2009-04-01

    Transient absorption spectroscopy is a powerful tool for the study of photoreactions on time scales from femtoseconds to seconds. Typically, reactions slower than ˜1 ns are recorded by the "classical" technique; the reaction is triggered by an excitation flash, and absorption changes accompanying the reaction are recorded in real time using a continuous monitoring light beam and a detection system with sufficiently fast response. The pico- and femtosecond region can be accessed by the more recent "pump-probe" technique, which circumvents the difficulties of real time detection on a subnanosecond time scale. This is paid for by accumulation of an excessively large number of shots to sample the reaction kinetics. Hence, it is of interest to extend the classical real time technique as far as possible to the subnanosecond range. In order to identify and minimize detection artifacts common on a subnanosecond scale, like overshoot, ringing, and signal reflections, rigorous testing is required of how the detection system responds to fast changes of the monitoring light intensity. Here, we introduce a novel method to create standard signals for detector fidelity testing on a time scale from a few picoseconds to tens of nanoseconds. The signals result from polarized measurements of absorption changes upon excitation of ruthenium complexes {[Ru(bpy)3]2+ and a less symmetric derivative} by a short laser flash. Two types of signals can be created depending on the polarization of the monitoring light with respect to that of the excitation flash: a fast steplike bleaching at magic angle and a monoexponentially decaying bleaching for parallel polarizations. The lifetime of the decay can be easily varied via temperature and viscosity of the solvent. The method is applied to test the performance of a newly developed real time transient absorption setup with 300 ps time resolution and high sensitivity.

  2. Reactivity Initiated Accident Simulation to Inform Transient Testing of Candidate Advanced Cladding

    SciTech Connect

    Brown, Nicholas R; Wysocki, Aaron J; Terrani, Kurt A

    2016-01-01

    Abstract. Advanced cladding materials with potentially enhanced accident tolerance will yield different light water reactor performance and safety characteristics than the present zirconium-based cladding alloys. These differences are due to different cladding material properties and responses to the transient, and to some extent, reactor physics, thermal, and hydraulic characteristics. Some of the differences in reactors physics characteristics will be driven by the fundamental properties (e.g., absorption in iron for an iron-based cladding) and others will be driven by design modifications necessitated by the candidate cladding materials (e.g., a larger fuel pellet to compensate for parasitic absorption). Potential changes in thermal hydraulic limits after transition from the current zirconium-based cladding to the advanced materials will also affect the transient response of the integral fuel. This paper leverages three-dimensional reactor core simulation capabilities to inform on appropriate experimental test conditions for candidate advanced cladding materials in a control rod ejection event. These test conditions are using three-dimensional nodal kinetics simulations of a reactivity initiated accident (RIA) in a representative state-of-the-art pressurized water reactor with both nuclear-grade iron-chromium-aluminum (FeCrAl) and silicon carbide based (SiC-SiC) cladding materials. The effort yields boundary conditions for experimental mechanical tests, specifically peak cladding strain during the power pulse following the rod ejection. The impact of candidate cladding materials on the reactor kinetics behavior of RIA progression versus reference zirconium cladding is predominantly due to differences in: (1) fuel mass/volume/specific power density, (2) spectral effects due to parasitic neutron absorption, (3) control rod worth due to hardened (or softened) spectrum, and (4) initial conditions due to power peaking and neutron transport cross sections in the

  3. Improving referrals for tilt table testing in patients with transient loss of consciousness

    PubMed Central

    Thornton, Luke; Rahunathan, Nithusa; Verma, Narain; Wong, Kenneth

    2016-01-01

    Tilt table testing has been used for over twenty years in the investigation of patients with transient loss of consciousness. The European Society of Cardiology (ESC) recently recommended new guidance regarding indications for tilt table testing. We conducted an educational intervention and produced a new referral proforma that referring clinicians are expected to fill in for all patients referred for tilt table testing. At baseline, 76% (n=84) of referrals for tilt table testing were made in accordance to ESC guidance. Following a simple educational intervention, 100% (n=6) were in line with ESC guidance. After the introduction of the referral proforma, 92% (n=12) of referrals followed ESC guidance. At final data collection, 100% (n=11) of referrals followed ESC guidance. In conclusion, a simple educational intervention and the use of a referral proforma in this quality improvement project have made a sustained difference in improving the appropriateness of referrals for tilt table testing. This has the potential to optimise the efficient use of resources and improve patient care through avoiding unnecessary investigation. PMID:27096093

  4. Review of behavior of mixed-oxide fuel elements in extended overpower transient tests in EBR-II

    SciTech Connect

    Tsai, H.; Neimark, L.A.; Nagai, S.; Nakae, N.

    1994-10-01

    From a series of five tests conducted in EBR-II, a substantial data base has been established on the performance of mixed-oxide fuel elements in a liquid-metal-cooled reactor under slow-ramp transient overpower conditions. Each test contained 19 preirradiated fuel elements with varying design and prior operating histories. Elements with aggressive design features, such as high fuel smear density and/or thin cladding, were included to accentuate transient effects. The ramp rates were either 0.1 or 10% {Delta}P/P/s and the overpowers ranged between {approx}60 and 100% of the elements` prior power ratings. Six elements breached during the tests, all with aggressive design parameters. The other elements, including all those with moderate design features for the reference or advanced long-life drivers for PNC`s prototype fast reactor Monju, maintained their cladding integrity during the tests. Posttest examination results indicated that fuel/cladding mechanical interaction (FCMI) was the most significant mechanism causing the cladding strain and breach. In contrast, pressure loading from the fission gas in the element plenum was less important, even in high-burnup elements. During an overpower transient, FCMI arises from fuel/cladding differential thermal expansion, transient fuel swelling, and, significantly, the gas pressure in the sealed central cavity of elements with substantial centerline fuel melting. Fuel performance data from these tests, including cladding breaching margin and transient cladding strain, are correlatable with fuel-element design and operating parameters. These correlations are being incorporated into fuel-element behavior codes. At the two tested ramp rates, fuel element behavior appears to be insensitive to transient ramp rate and there appears to be no particular vulnerability to slow ramp transients as previously perceived.

  5. Transient operation and shape optimization of a single PEM fuel cell

    NASA Astrophysics Data System (ADS)

    Chen, Sheng; Ordonez, Juan C.; Vargas, Jose V. C.; Gardolinski, Jose E. F.; Gomes, Maria A. B.

    Geometric design, including the internal structure and external shape, considerably affect the thermal, fluid, and electrochemical characteristics of a polymer electrolyte membrane (PEM) fuel cell, which determine the polarization curves as well as the thermal and power inertias. Shape optimization is a natural alternative to improve the fuel cell performance and make fuel cells more attractive for power generation. This paper investigates the internal and external structure effects on the fuel cell steady and transient operation with consideration of stoichiometric ratios, pumping power, and working temperature limits. The maximal steady state net power output and the fuel cell start-up time under a step-changed current load characterize the fuel cell steady and transient performance respectively. The one-dimensional PEM fuel cell (PEMFC) thermal model introduced in a previous work [J.V.C. Vargas, J.C. Ordonez, A. Bejan, Constructal flow structure for a PEM fuel cell, Int. J. Heat Mass Transfer 47 (2004) 4177-4193] is amended to simulate the fuel cell transient start-up process. The shape optimization consists of the internal and external PEMFC structure optimization. The internal optimization focuses on the optimal allocation of fuel cell compartment thicknesses. The external optimization process seeks the PEM fuel cell optimal external aspect ratios. These two levels of optimizations pursue the optimal geometric design with quick response to the step loads and large power densities. Appropriate dimensionless groups are identified and the numerical results are presented in dimensionless charts for general engineering design. The universality of the general optimal shape found is also discussed.

  6. High-Speed Single-Event Current Transient Measurements in SiGe HBTs

    NASA Technical Reports Server (NTRS)

    Pellish, Jonathan A.; Reed, R.A.; McMorrow, D.; Vizkelethy, G.; Ferlet-Cavrois, V.; Baggio, J.; Paillet, P.; Duhamel, O.; Phillips, S.D.; Sutton, A.K.; Diestelhorst, R.M.; Cressler, J.D.; Dodd, P.E.; Pate, N.D.; Alles, M.L.; Schrimpf, R.D.; Marshall, P.W.; LaBel, K.A.

    2009-01-01

    Time-resolved ion beam induced charge reveals heavy ion response of IBM 5AM SiGe HBT: 1) Position correlation. 2) Unique response for different bias schemes. 3) Similarities to TPA pulsed-laser data. Heavy ion broad-beam transients provide more realistic device response: 1) Feedback using microbeam data 2) Overcome existing issues of LET and ion range with microbeam Both micro- and broad-beam data sets yield valuable input for TCAD simulations. Uncover detailed mechanisms for SiGe HBTs and other devices fabricated on lightly-doped substrates.

  7. Searches for Radio Pulsars & Fast Transients and Multiwavelength Studies of Single-pulse Emission

    NASA Astrophysics Data System (ADS)

    Mickaliger, Mitchell B.

    Pulsars are excellent tools for studying a wide array of astrophysical phenomena (e.g. gravitational waves, the interstellar medium, general relativity), yet they are still not fully understood. What are their emission processes and how do they change at different energies? How is giant pulse emission different from regular emission? How are different classes of pulsars (RRATs, magnetars, nulling pulsars, etc.) related? Answering these questions will not only help us to understand pulsars in general, but will also help improve techniques for pulsar searches and timing, gravitational wave searches, and single-pulse searches. The work we present here aims to answer these questions through studies of giant pulse emission, the discovery of new pulsars, and single-pulse studies of a large population of pulsars and RRATs. We took advantage of open telescope time on the 43-m telescope in Green Bank, WV to conduct a long-term study of giant pulses from the Crab pulsar at 1.2 GHz and 330 MHz. Over a timespan of 15 months, we collected a total of 95000 giant pulses which we correlated with both gamma-ray photons from the Fermi satellite and giant pulses collected at 8.9 GHz. Statistics of these pulses show that their amplitudes follow power-law distributions, with indices in the range of 2.1 to 3.1. The correlation with giant pulses at 8.9 GHz showed that the emission processes at 1.2 GHz and 8.9 GHz are related, despite significant profile differences. The correlation with Fermi gamma-ray photons was to test if increased pair production in the magnetosphere was the cause of giant pulses. Our findings suggest that, while it may play a role, increased pair production is not the dominant cause of giant pulses. As part of a single-pulse study, we reprocessed the archival Parkes Multibeam Pulsar Survey, discovering six previously unknown pulsars. PSR J0922-52 has a period of 9.68 ms and a DM of 122.4 pc cm-3. PSR J1147-66 has a period of 3.72 ms and a DM of 133.8 pc cm-3. PSR J

  8. Measuring the Optical Performance of Evacuated Receivers via an Outdoor Thermal Transient Test: Preprint

    SciTech Connect

    Kutscher, C.; Burkholder, F.; Netter, J.

    2011-08-01

    Modern parabolic trough solar collectors operated at high temperatures to provide the heat input to Rankine steam power cycles employ evacuated receiver tubes along the collector focal line. High performance is achieved via the use of a selective surface with a high absorptance for incoming short-wave solar radiation and a low emittance for outgoing long-wave infrared radiation, as well as the use of a hard vacuum to essentially eliminate convective and conductive heat losses. This paper describes a new method that determines receiver overall optical efficiency by exposing a fluid-filled, pre-cooled receiver to one sun outdoors and measuring the slope of the temperature curve at the point where the receiver temperature passes the glass envelope temperature (that is, the point at which there is no heat gain or loss from the absorber). This transient test method offers the potential advantages of simplicity, high accuracy, and the use of the actual solar spectrum.

  9. 40 CFR Appendix I to Part 1037 - Heavy-Duty Transient Chassis Test Cycle

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....00 169 0.00 0.00 170 0.00 0.00 171 0.00 0.00 172 1.11 0.50 173 2.65 1.18 174 4.45 1.99 175 5.68 2.54... 1.61 0.72 431 1.53 0.68 432 2.34 1.05 433 4.29 1.92 434 7.25 3.24 435 10.20 4.56 436 12.46 5.57 437... Appendix I to Part 1037—Heavy-Duty Transient Chassis Test Cycle Timesec. Speedmph Speedm/s 1 0.00......

  10. Transient Plume Model Testing Using LADEE Spacecraft Attitude Control System Operations

    NASA Astrophysics Data System (ADS)

    Woronowicz, M. S.

    2011-05-01

    The Lunar Atmosphere Dust Environment Explorer (LADEE) spacecraft is being designed for a mission featuring low altitude orbits of the Moon to take relevant ambient measurements before that environment becomes altered by future exploration activities. Instruments include a neutral mass spectrometer capable of measuring ambient species density levels below 100 molecules/cm3. Coincidentally, with a favorable combination of spacecraft orientations, it is also possible to measure plume gases from LADEE attitude control system thruster operations as they are reflected from the daytime lunar surface and subsequently intercepted by the spacecraft as it orbits overhead. Under such circumstances, it may be possible to test a variety of properties and assumptions associated with various transient plume models or to infer certain aspects regarding lunar surface properties.

  11. Transient Plume Model Testing Using LADEE Spacecraft Attitude Control System Operations

    SciTech Connect

    Woronowicz, M. S.

    2011-05-20

    The Lunar Atmosphere Dust Environment Explorer (LADEE) spacecraft is being designed for a mission featuring low altitude orbits of the Moon to take relevant ambient measurements before that environment becomes altered by future exploration activities. Instruments include a neutral mass spectrometer capable of measuring ambient species density levels below 100 molecules/cm{sup 3}. Coincidentally, with a favorable combination of spacecraft orientations, it is also possible to measure plume gases from LADEE attitude control system thruster operations as they are reflected from the daytime lunar surface and subsequently intercepted by the spacecraft as it orbits overhead. Under such circumstances, it may be possible to test a variety of properties and assumptions associated with various transient plume models or to infer certain aspects regarding lunar surface properties.

  12. 40 CFR Appendix E to Subpart S of... - Transient Test Driving Cycle

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36.2 162 37.3 163 39.3 164 40.5 165 42.1 166 43.5 167 45.1 168 46 169 46.8 170 47.5 171 47.5 172 47.3... transient IM240 test procedure. Second MPH 0 0 1 0 2 0 3 0 4 0 5 3 6 5.9 7 8.6 8 11.5 9 14.3 10 16.9 11 17.3... 25 15.2 26 15.5 27 16 28 17.1 29 19.1 30 21.1 31 22.7 32 22.9 33 22.7 34 22.6 35 21.3 36 19 37...

  13. 40 CFR Appendix E to Subpart S of... - Transient Test Driving Cycle

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36.2 162 37.3 163 39.3 164 40.5 165 42.1 166 43.5 167 45.1 168 46 169 46.8 170 47.5 171 47.5 172 47.3... transient IM240 test procedure. Second MPH 0 0 1 0 2 0 3 0 4 0 5 3 6 5.9 7 8.6 8 11.5 9 14.3 10 16.9 11 17.3... 25 15.2 26 15.5 27 16 28 17.1 29 19.1 30 21.1 31 22.7 32 22.9 33 22.7 34 22.6 35 21.3 36 19 37...

  14. The Use of Randomization Tests in Single-Subject Research

    ERIC Educational Resources Information Center

    Haardorfer, Regine; Gagne, Phill

    2010-01-01

    Some researchers have argued for the use of or have attempted to make use of randomization tests in single-subject research. To address this tide of interest, the authors of this article describe randomization tests, discuss the theoretical rationale for applying them to single-subject research, and provide an overview of the methodological…

  15. Barometric pressure transient testing applications at the Nevada Test Site. Nuclear chimney analysis. Final report

    SciTech Connect

    Hanson, J.M.

    1985-12-01

    Investigations of barometric pressure testing of NTS nuclear chimneys were reviewed. This review includes the models used in the interpretation, methods of analysis, and results. Analytic and semi-analytic models were presented and applied to both historical data and new data taken for this current project. An interpretation technique based on non-linear least squares methods was used to analyze this data in terms of historic and more recent chimney models. Finally, a detailed discussion of radioactive gas transport due to surface barometric pressure fluctuations was presented. This mechanism of transport, referred to as ''barometric pumping,'' is presented in terms of conditions likely to be encountered at the NTS. The report concludes with a discussion of the current understanding of gas flow properties in the alluvial and volcanic areas of the NTS, and suggestions for future efforts directed toward increasing this understanding are presented.

  16. Single-file diffusion of particles in a box: Transient behaviors

    NASA Astrophysics Data System (ADS)

    Delfau, Jean-Baptiste; Coste, Christophe; Saint Jean, Michel

    2012-06-01

    We consider a finite number of particles with soft-core interactions, subjected to thermal fluctuations and confined in a box with excluded mutual passage. Using numerical simulations, we focus on the influence of the longitudinal confinement on the transient behavior of the longitudinal mean squared displacement. We exhibit several power laws for its time evolution according to the confinement range and to the rank of the particle in the file. We model the fluctuations of the particles as those of a chain of springs and point masses in a thermal bath. Our main conclusion is that actual system dynamics can be described in terms of the normal oscillation modes of this chain. Moreover, we obtain complete expressions for the physical observables, in excellent agreement with our simulations. The correct power laws for the time dependency of the mean squared displacement in the various regimes are recovered, and analytical expressions of the prefactors according to the relevant parameters are given.

  17. Photo-induced current transient spectroscopy of single crystal Tl6I4Se

    NASA Astrophysics Data System (ADS)

    Liu, Z.; Peters, J. A.; Sebastian, M.; Kanatzidis, M. G.; Im, J.; Freeman, A. J.; Wessels, B. W.

    2014-11-01

    The compound Tl6I4Se is a promising wide band gap semiconductor for hard radiation detection at room temperature. To further improve its detection efficiency, native defects have been investigated using photo-induced current transient spectroscopy (PICTS). We observe two shallow acceptor levels with mean activation energies of 76, 175 meV, and two shallow donor defects 62, and 96 meV, respectively. No deeper donor levels are observed. The levels are attributed to native point defects. Defect capture cross sections in the range 10-21 to 10-18 cm2 were measured. The small capture cross sections are attributed to the effective screening of the defects due to a large static dielectric constant.

  18. Impacts Analyses Supporting the National Environmental Policy Act Environmental Assessment for the Resumption of Transient Testing Program

    SciTech Connect

    Annette L. Schafer; Lloyd C. Brown; David C. Carathers; Boyd D. Christensen; James J. Dahl; Mark L. Miller; Cathy Ottinger Farnum; Steven Peterson; A. Jeffrey Sondrup; Peter V. Subaiya; Daniel M. Wachs; Ruth F. Weiner

    2013-11-01

    Environmental and health impacts are presented for activities associated with transient testing of nuclear fuel and material using two candidate test reactors. Transient testing involves irradiation of nuclear fuel or materials for short time-periods under high neutron flux rates. The transient testing process includes transportation of nuclear fuel or materials inside a robust shipping cask to a hot cell, removal from the shipping cask, pre-irradiation examination of the nuclear materials, assembly of an experiment assembly, transportation of the experiment assembly to the test reactor, irradiation in the test reactor, transport back to the hot cell, and post-irradiation examination of the nuclear fuel or material. The potential for environmental or health consequences during the transportation, examination, and irradiation actions are assessed for normal operations, off-normal (accident) scenarios, and transportation. Impacts to the environment (air, soil, and groundwater), are assessed during each phase of the transient testing process. This report documents the evaluation of potential consequences to the general public. This document supports the Environmental Assessment (EA) required by the U.S. National Environmental Policy Act (NEPA) (42 USC Subsection 4321 et seq.).

  19. Particle Tracking-Based Strategies For Simulating Transport in a Transient Groundwater Flow Field at Yucca Flat, Nevada Test Site, USA

    NASA Astrophysics Data System (ADS)

    Keating, E. H.; Srinivasan, G.; Kang, Q.; Li, C.; Dash, Z.; Kwicklis, E. M.

    2009-12-01

    Developing probabilistic-based calculations of contaminant concentrations over the next 1000 years at Yucca Flat, Nevada Test site, require tremendous computational effort in this highly complex hydrogeologic surface environment. The sources of contamination, underground nuclear tests conducted between 1951 and 1992, not only released radionuclides to the subsurface but also created abrupt, significant changes in rock properties and caused large transients in the measured hydraulic gradients. To efficiently model contaminant migration from these sources we use a particle-based approach within a transient flow field. Here, we present results using two methods; first, an explicit representation of time-varying sources using large numbers of particles introduced at source-specific rates over time, each representing a unique mass of solute. This method provides good results, but is computationally expensive since sensitivity to uncertainty in source term and transport parameters can only be explored with discrete process-model runs. The second method employs a convolution method (PLUMECALC) which can efficiently consider a large number of variations in the source terms and in certain transport parameters with a single process-model run. Implementation of this second approach required extension of the existing methodology to conditions of transient flow. We find very good comparison between the two methods on small test problems and excellent computational advantages when applying the convolution method in the NTS application

  20. Single Event Effects (SEE) Testing: Practical Approach to Test Plans

    NASA Technical Reports Server (NTRS)

    LaBel, Kenneth A.; Pellish, Jonathan Allen; Berg, Melanie D.

    2014-01-01

    While standards and guidelines for performing SEE testing have existed for several decades, guidance for developing SEE test plans has not been as easy to find. In this presentation, the variety of areas that need to be considered ranging from resource issues (funds, personnel, schedule) to extremely technical challenges (particle interaction and circuit application), shall be discussed. Note: we consider the approach outlined here as a "living" document: Mission-specific constraints and new technology related issues always need to be taken into account.

  1. Impacts Analyses Supporting the National Environmental Policy Act Environmental Assessment for the Resumption of Transient Testing Program

    SciTech Connect

    Annette L. Schafer; LLoyd C. Brown; David C. Carathers; Boyd D. Christensen; James J. Dahl; Mark L. Miller; Cathy Ottinger Farnum; Steven Peterson; A. Jeffrey Sondrup; Peter V. Subaiya; Daniel M. Wachs; Ruth F. Weiner

    2014-02-01

    This document contains the analysis details and summary of analyses conducted to evaluate the environmental impacts for the Resumption of Transient Fuel and Materials Testing Program. It provides an assessment of the impacts for the two action alternatives being evaluated in the environmental assessment. These alternatives are (1) resumption of transient testing using the Transient Reactor Test Facility (TREAT) at Idaho National Laboratory (INL) and (2) conducting transient testing using the Annular Core Research Reactor (ACRR) at Sandia National Laboratory in New Mexico (SNL/NM). Analyses are provided for radiologic emissions, other air emissions, soil contamination, and groundwater contamination that could occur (1) during normal operations, (2) as a result of accidents in one of the facilities, and (3) during transport. It does not include an assessment of the biotic, cultural resources, waste generation, or other impacts that could result from the resumption of transient testing. Analyses were conducted by technical professionals at INL and SNL/NM as noted throughout this report. The analyses are based on bounding radionuclide inventories, with the same inventories used for test materials by both alternatives and different inventories for the TREAT Reactor and ACRR. An upper value on the number of tests was assumed, with a test frequency determined by the realistic turn-around times required between experiments. The estimates provided for impacts during normal operations are based on historical emission rates and projected usage rates; therefore, they are bounding. Estimated doses for members of the public, collocated workers, and facility workers that could be incurred as a result of an accident are very conservative. They do not credit safety systems or administrative procedures (such as evacuation plans or use of personal protective equipment) that could be used to limit worker doses. Doses estimated for transportation are conservative and are based on

  2. High intensity single bunch operation with heavy periodic transient beam loading in wide band rf cavities

    NASA Astrophysics Data System (ADS)

    Tamura, Fumihiko; Hotchi, Hideaki; Schnase, Alexander; Yoshii, Masahito; Yamamoto, Masanobu; Ohmori, Chihiro; Nomura, Masahiro; Toda, Makoto; Shimada, Taihei; Hasegawa, Katsushi; Hara, Keigo

    2015-09-01

    The rapid cycling synchrotron (RCS) in the Japan Proton Accelerator Research Complex (J-PARC) was originally designed to accelerate two high intensity bunches, while some of neutron experiments in the materials and life science experimental facility and a muon experiment using main ring beams require a single bunch operation mode, in which one of the two rf buckets is filled and the other is empty. The beam intensity in the single bunch operation has been limited by longitudinal beam losses due to the rf bucket distortions by the wake voltage of the odd harmonics (h =1 ,3 ,5 ) in the wide band magnetic alloy cavities. We installed an additional rf feedforward system to compensate the wake voltages of the odd harmonics (h =1 ,3 ,5 ). The additional system has a similar structure as the existing feedforward system for the even harmonics (h =2 ,4 ,6 ). We describe the function of the feedforward system for the odd harmonics, the commissioning methodology, and the commissioning results. The longitudinal beam losses during the single bunch acceleration disappeared with feedforward for the odd harmonics. We also confirmed that the beam quality in the single bunch acceleration are similar to that of the normal operation with two bunches. Thus, high intensity single bunch acceleration at the intensity of 2.3 ×1013 protons per bunch has been achieved in the J-PARC RCS. This article is a follow-up of our previous article, Phys. Rev. ST Accel. Beams 14, 051004 (2011). The feedforward system extension for single bunch operation was successful.

  3. Single shaft automotive gas turbine engine characterization test

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1979-01-01

    An automotive gas turbine incorporating a single stage centrifugal compressor and a single stage radial inflow turbine is described. Among the engine's features is the use of wide range variable geometry at the inlet guide vanes, the compressor diffuser vanes, and the turbine inlet vanes to achieve improved part load fuel economy. The engine was tested to determine its performance in both the variable geometry and equivalent fixed geometry modes. Testing was conducted without the originally designed recuperator. Test results were compared with the predicted performance of the nonrecuperative engine based on existing component rig test maps. Agreement between test results and the computer model was achieved.

  4. Effects of imipramine on the transient outward current in rabbit atrial single cells.

    PubMed

    Delpón, E; Tamargo, J; Sánchez-Chapula, J

    1992-06-01

    1. The effects of imipramine on action potential characteristics and transient outward potassium current (It) of rabbit isolated atrial myocytes were studied using the whole-cell configuration of the patch-clamp technique. 2. Imipramine, 3 microM, decreased action potential amplitude and lengthened the action potential duration measured at 50% of repolarization, whereas it did not modify the final phase of repolarization or the resting membrane potential. These results are similar to those reported in multicellular rabbit atrial preparations. 3. Imipramine, 0.1-100 microM, induced a concentration-dependent inhibition of the peak amplitude of It, a shortening of the time to peak current and an increase in the inactivation rate. The acceleration of the current inactivation is to a major extent responsible for the decrease in the integral of the outward current measured at 50 ms after the start of the pulse. 4. The drug-induced block of It was not associated with changes in the voltage-dependence of the steady-state inactivation curve or in the process of recovery from inactivation of the current. Extrapolation to zero block shows that imipramine did not block It before its activation at the onset of the depolarization. These results suggested that imipramine does not affect the inactivated or the resting state of It channels. 5. It is concluded that in rabbit isolated atrial cells, imipramine inhibits It and that this effect is responsible for the lengthening of the action potential duration produced by this drug.

  5. Effects of imipramine on the transient outward current in rabbit atrial single cells.

    PubMed Central

    Delpón, E.; Tamargo, J.; Sánchez-Chapula, J.

    1992-01-01

    1. The effects of imipramine on action potential characteristics and transient outward potassium current (It) of rabbit isolated atrial myocytes were studied using the whole-cell configuration of the patch-clamp technique. 2. Imipramine, 3 microM, decreased action potential amplitude and lengthened the action potential duration measured at 50% of repolarization, whereas it did not modify the final phase of repolarization or the resting membrane potential. These results are similar to those reported in multicellular rabbit atrial preparations. 3. Imipramine, 0.1-100 microM, induced a concentration-dependent inhibition of the peak amplitude of It, a shortening of the time to peak current and an increase in the inactivation rate. The acceleration of the current inactivation is to a major extent responsible for the decrease in the integral of the outward current measured at 50 ms after the start of the pulse. 4. The drug-induced block of It was not associated with changes in the voltage-dependence of the steady-state inactivation curve or in the process of recovery from inactivation of the current. Extrapolation to zero block shows that imipramine did not block It before its activation at the onset of the depolarization. These results suggested that imipramine does not affect the inactivated or the resting state of It channels. 5. It is concluded that in rabbit isolated atrial cells, imipramine inhibits It and that this effect is responsible for the lengthening of the action potential duration produced by this drug. PMID:1382783

  6. Hanford single shell tank saltcake cesium removal test plan

    SciTech Connect

    Duncan, J.B., Westinghouse Hanford

    1996-12-11

    This document provides the test preparation and conduct of a cesium removal test using Hanford Single Shell Tank Saltcake from tanks 241-BY-110, 241-U-108, 241 U 109, 241-A-101, and 241-S-102 in a benchscale column. The cesium sorbent to be tested is crystalline silicotitanate

  7. 40 CFR 1039.510 - Which duty cycles do I use for transient testing?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION... consists of an initial run through the transient duty cycle from a cold start, 20 minutes with no engine operation, then a final run through the same transient duty cycle. Start sampling emissions...

  8. 40 CFR 1039.510 - Which duty cycles do I use for transient testing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION... consists of an initial run through the transient duty cycle from a cold start, 20 minutes with no engine operation, then a final run through the same transient duty cycle. Start sampling emissions...

  9. 40 CFR 1039.510 - Which duty cycles do I use for transient testing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION... sequence consists of an initial run through the transient duty cycle from a cold start, 20 minutes with no engine operation, then a final run through the same transient duty cycle. Calculate the...

  10. Classification methods for noise transients in advanced gravitational-wave detectors II: performance tests on Advanced LIGO data

    NASA Astrophysics Data System (ADS)

    Powell, Jade; Torres-Forné, Alejandro; Lynch, Ryan; Trifirò, Daniele; Cuoco, Elena; Cavaglià, Marco; Heng, Ik Siong; Font, José A.

    2017-02-01

    The data taken by the advanced LIGO and Virgo gravitational-wave detectors contains short duration noise transients that limit the significance of astrophysical detections and reduce the duty cycle of the instruments. As the advanced detectors are reaching sensitivity levels that allow for multiple detections of astrophysical gravitational-wave sources it is crucial to achieve a fast and accurate characterization of non-astrophysical transient noise shortly after it occurs in the detectors. Previously we presented three methods for the classification of transient noise sources. They are Principal Component Analysis for Transients (PCAT), Principal Component LALInference Burst (PC-LIB) and Wavelet Detection Filter with Machine Learning (WDF-ML). In this study we carry out the first performance tests of these algorithms on gravitational-wave data from the Advanced LIGO detectors. We use the data taken between the 3rd of June 2015 and the 14th of June 2015 during the 7th engineering run (ER7), and outline the improvements made to increase the performance and lower the latency of the algorithms on real data. This work provides an important test for understanding the performance of these methods on real, non stationary data in preparation for the second advanced gravitational-wave detector observation run, planned for later this year. We show that all methods can classify transients in non stationary data with a high level of accuracy and show the benefits of using multiple classifiers.

  11. Single Event Effects Testing of the Linfinity SG1525A Pulse Width Modulator Controller

    NASA Technical Reports Server (NTRS)

    Howard, J. W., Jr.; Carts, M. A.; LaBel, K. A.; Forney, J. D.; Irwin, T. L.

    2003-01-01

    Pulse Width Modulator (PWM) Controllers are the heart of switching power supply systems in development today. The PWMs considered here have the same integration advantages as many other controllers but it also includes the interface drivers for the follow-on power Field Effect Transistors (FET). Previous work on these types of devices looked into the required test methodologies [ 11 and the impact of radiation on the soft start and shutdown circuits of typically incorporated in the technology [2]. Taking advantage of this previous work this study was undertaken to determine the single event destructive and transient susceptibility of the Linfinity SG1525A Pulse Width Modulator Controller. The device was monitored for transient interruptions in the output signals and for destructive events induced by exposing it to a heavy ion beam at the Texas A&M University Cyclotron Single Event Effects Test Facility. After exposing these devices to the beam, a new upset mode has been identified that can lead to catastrophic power supply system failure if this event would occur while drive power FETs off the two device outputs. The devices and the test methods used will be described first. This will be followed by a brief description of the data collected to date (not all data can be presented with the length constraints of the summary) and a summary of the key results.

  12. Local anaesthetics transiently block currents through single acetylcholine-receptor channels.

    PubMed Central

    Neher, E; Steinbach, J H

    1978-01-01

    1. Single channel currents through acetylcholine receptor channels (ACh channels) were recorded at chronically denervated frog muscle extrajunctional membranes in the absence and presence of the lidocaine derivatives QX-222 and QX-314. 2. The current wave forms due to the opening and closing of single ACh channels (activated by suberyldicholine) normally are square pulses. These single pulses appear to be chopped into bursts of much shorter pulses, when the drug QX-222 is present in addition to the agonist. 3. The mean duration of the bursts is comparable to or longer than the normal channel open time, and increases with increasing drug concentration. 4. The duration of the short pulses within a burst decreases with increasing drug concentration. 5. It is concluded that drug molecules reversibly block open end-plate channels and that the flickering within a burst represents this fast, repeatedly occurring reaction. 6. The voltage dependence of the reaction rates involved, suggested that the site of the blocking reaction is in the centre of the membrane, probably inside the ionic channel. PMID:306437

  13. Modeling of single event transients with dual double-exponential current sources: Implications for logic cell characterization

    SciTech Connect

    Black, Dolores Archuleta; Robinson, William H.; Wilcox, Ian Zachary; Limbrick, Daniel B.; Black, Jeffrey D.

    2015-08-07

    Single event effects (SEE) are a reliability concern for modern microelectronics. Bit corruptions can be caused by single event upsets (SEUs) in the storage cells or by sampling single event transients (SETs) from a logic path. Likewise, an accurate prediction of soft error susceptibility from SETs requires good models to convert collected charge into compact descriptions of the current injection process. This paper describes a simple, yet effective, method to model the current waveform resulting from a charge collection event for SET circuit simulations. The model uses two double-exponential current sources in parallel, and the results illustrate why a conventional model based on one double-exponential source can be incomplete. Furthermore, a small set of logic cells with varying input conditions, drive strength, and output loading are simulated to extract the parameters for the dual double-exponential current sources. As a result, the parameters are based upon both the node capacitance and the restoring current (i.e., drive strength) of the logic cell.

  14. Modeling of single event transients with dual double-exponential current sources: Implications for logic cell characterization

    DOE PAGES

    Black, Dolores Archuleta; Robinson, William H.; Wilcox, Ian Zachary; ...

    2015-08-07

    Single event effects (SEE) are a reliability concern for modern microelectronics. Bit corruptions can be caused by single event upsets (SEUs) in the storage cells or by sampling single event transients (SETs) from a logic path. Likewise, an accurate prediction of soft error susceptibility from SETs requires good models to convert collected charge into compact descriptions of the current injection process. This paper describes a simple, yet effective, method to model the current waveform resulting from a charge collection event for SET circuit simulations. The model uses two double-exponential current sources in parallel, and the results illustrate why a conventionalmore » model based on one double-exponential source can be incomplete. Furthermore, a small set of logic cells with varying input conditions, drive strength, and output loading are simulated to extract the parameters for the dual double-exponential current sources. As a result, the parameters are based upon both the node capacitance and the restoring current (i.e., drive strength) of the logic cell.« less

  15. The Single Sample Chi-Square Test: Lesson Plan.

    ERIC Educational Resources Information Center

    Yang, Shouu-Chyuan

    This lesson plan is designed to enable a student, after 50 minutes of instruction, to define the single sample chi-square test and explain the three conditions necessary to its proper use and the purpose of using it. The student will also be able to calculate and apply the single sample chi-square test in class according to the five steps with the…

  16. COMMIX-1AR/P: A three-dimensional transient single-phase computer program for thermal hydraulic analysis of single and multicomponent systems

    SciTech Connect

    Garner, P.L.; Blomquist, R.N.; Gelbard, E.M.

    1992-09-01

    The COMMIX-1AR/P computer program is designed for analyzing the steady-state and transient aspects of single-phase fluid flow and heat transfer in three spatial dimensions. This version is an extension of the modeling in COMMIX-1A to include multiple fluids in physically separate regions of the computational domain, modeling descriptions for pumps, radiation heat transfer between surfaces of the solids which are embedded in or surround the fluid, a k-[var epsilon] model for fluid turbulence, and improved numerical techniques. The porous-medium formulation in COMMIX allows the program to be applied to a wide range of problems involving both simple and complex geometrical arrangements. The input preparation and execution procedures are presented for the COMMIX-1AR/P program and several postprocessor programs which produce graphical displays of the calculated results.

  17. COMMIX-1AR/P: A three-dimensional transient single-phase computer program for thermal hydraulic analysis of single and multicomponent systems

    SciTech Connect

    Garner, P.L.; Blomquist, R.N.; Gelbard, E.M.

    1992-09-01

    The COMMIX-LAR/P computer program is designed for analyzing the steady-state and transient aspects of single-phase fluid flow and heat transfer in three spatial dimensions. This version is an extension of the modeling in COMMIX-lA to include multiple fluids in physically separate regions of the computational domain, modeling descriptions for pumps, radiation heat transfer between surfaces of the solids which are embedded in or surround the fluid, a keg model for fluid turbulence, and improved numerical techniques. The porous-medium formulation in COMMIX allows the program to be applied to a wide range of problems involving both simple and complex geometrical arrangements. The internal aspects of the COMMIX-LAR/P program are presented, covering descriptions of subprograms, variables, and files.

  18. Method for experimental investigation of transient operation on Laval test stand for model size turbines

    NASA Astrophysics Data System (ADS)

    Fraser, R.; Coulaud, M.; Aeschlimann, V.; Lemay, J.; Deschenes, C.

    2016-11-01

    With the growing proportion of inconstant energy source as wind and solar, hydroelectricity becomes a first class source of peak energy in order to regularize the grid. The important increase of start - stop cycles may then cause a premature ageing of runners by both a higher number of cycles in stress fluctuations and by reaching a higher stress level in absolute. Aiming to sustain good quality development on fully homologous scale model turbines, the Hydraulic Machines Laboratory (LAMH) of Laval University has developed a methodology to operate model size turbines on transient regimes such as start-up, stop or load rejection on its test stand. This methodology allows maintaining a constant head while the wicket gates are opening or closing in a representative speed on the model scale of what is made on the prototype. This paper first presents the opening speed on model based on dimensionless numbers, the methodology itself and its application. Then both its limitation and the first results using a bulb turbine are detailed.

  19. Selecting single model in combination forecasting based on cointegration test and encompassing test.

    PubMed

    Jiang, Chuanjin; Zhang, Jing; Song, Fugen

    2014-01-01

    Combination forecasting takes all characters of each single forecasting method into consideration, and combines them to form a composite, which increases forecasting accuracy. The existing researches on combination forecasting select single model randomly, neglecting the internal characters of the forecasting object. After discussing the function of cointegration test and encompassing test in the selection of single model, supplemented by empirical analysis, the paper gives the single model selection guidance: no more than five suitable single models can be selected from many alternative single models for a certain forecasting target, which increases accuracy and stability.

  20. Selecting Single Model in Combination Forecasting Based on Cointegration Test and Encompassing Test

    PubMed Central

    Jiang, Chuanjin; Zhang, Jing; Song, Fugen

    2014-01-01

    Combination forecasting takes all characters of each single forecasting method into consideration, and combines them to form a composite, which increases forecasting accuracy. The existing researches on combination forecasting select single model randomly, neglecting the internal characters of the forecasting object. After discussing the function of cointegration test and encompassing test in the selection of single model, supplemented by empirical analysis, the paper gives the single model selection guidance: no more than five suitable single models can be selected from many alternative single models for a certain forecasting target, which increases accuracy and stability. PMID:24892061

  1. The Effect of Transient Students' Scores on the Norm of One High School's Standardized Basic Skills Test Battery.

    ERIC Educational Resources Information Center

    Hill, Carolyn Stevens

    The effect of the standardized test scores of transient students on the mean of the 9th, 10th, and 11th grade standardized test scores of a school was studied. The groups used in the study were grades 9, 10, and 11 at a new high school in Clarksburg (West Virginia). The study was conducted in the spring of 1998. Groups consisted of 204 9th…

  2. Calcium transients during early development in single starfish (Asterias forbesi) oocytes

    PubMed Central

    1984-01-01

    Maturation and fertilization of the starfish oocyte are putative calcium-dependent events. We have investigated the spatial distribution and temporal dynamics of this calcium dependence in single oocytes of Asterias forbesi. We used the calcium photoprotein, aequorin, in conjunction with a microscope-photomultiplier and microscope-image intensifier. Surprisingly, in contrast to earlier work with Marasthenias glacialis, there is no detectable increase in intracellular-free calcium in the oocyte of A. forbesi in response to the maturation hormone 1-methyl adenine. During fertilization of the same, matured, A. forbesi oocyte there is a large increase in intracellular-free calcium. The calcium concentration increases to approximately 1 microM at the point of insemination and the region of elevated free calcium expands across the oocyte in approximately 20 s (17-19 degrees C). After the entire oocyte reaches an elevated concentration of free calcium, the concentration decreases uniformly throughout the oocyte over the next several minutes. PMID:6490725

  3. Sequential hydraulic tests for transient and highly permeable unconfined aquifer systems - model development and field-scale implementation

    NASA Astrophysics Data System (ADS)

    Ni, C.-F.; Huang, Y.-J.; Dong, J.-J.; Yeh, T.-C. J.

    2015-12-01

    The transient hydraulic tomography survey (THTS) is a conceptually improved technique that efficiently estimates detailed variations in aquifer parameters. Based on the concept of the THTS, we developed a geostatistical inverse model to characterize saturated hydraulic conductivity (K) and the specific yield (Sy) in transient and unconfined aquifer systems. In this study, a synthetic example was first used to assess the accuracy of the developed inverse model. Multiple random K and Sy realizations with different variances of natural logarithm of K (lnK) were generated and systematically compared to evaluate the effects of joint inversion on K estimations. The model was implemented in field-scale, cross-hole injection tests in a shallow and highly permeable unconfined aquifer near the middle reaches of the Wu River in central Taiwan. To assess the effect of constant head boundary conditions on the estimation results, two additional modeling domains were evaluated on the basis of the same field data from the injection tests. The results of the synthetic example showed that the proposed inverse model can effectively reproduce the predefined K patterns and magnitudes. However, slightly less detail was obtained for the Sy field based on the sampling data from sequential transient hydraulic stresses. The joint inversion by using transient head observations could slightly decrease the accuracy of K estimations. The model implementation for field-scale injection tests showed that the model can estimate K and Sy fields with detailed spatial variations. Estimation results showed a relatively homogeneous aquifer for the tested well field. Results based on the three modeling domains showed similar patterns and magnitudes of K and Sy near the well locations. These results indicated that the THTS is relatively insensitive to artificially drawn boundary conditions even under transient conditions.

  4. Transient and Steady-state Tests of the Space Power Research Engine with Resistive and Motor Loads

    NASA Technical Reports Server (NTRS)

    Rauch, Jeffrey S.; Kankam, M. David

    1995-01-01

    The NASA Lewis Research Center (LeRC) has been testing free-piston Stirling engine/linear alternators (FPSE/LA) to develop advanced power convertors for space-based electrical power generation. Tests reported herein were performed to evaluate the interaction and transient behavior of FPSE/LA-based power systems with typical user loads. Both resistive and small induction motor loads were tested with the space power research engine (SPRE) power system. Tests showed that the control system could maintain constant long term voltage and stable periodic operation over a large range of engine operating parameters and loads. Modest resistive load changes were shown to cause relatively large voltage and, therefore, piston and displacer amplitude excursions. Starting a typical small induction motor was shown to cause large and, in some cases, deleterious voltage transients. The tests identified the need for more effective controls, if FPSE/LAs are to be used for stand-alone power systems. The tests also generated a large body of transient dynamic data useful for analysis code validation.

  5. Visible Persistence of Single-Transient Random Dot Patterns: Spatial Parameters Affect the Duration of Fading Percepts

    PubMed Central

    Bruchmann, Maximilian; Thaler, Kathrin; Vorberg, Dirk

    2015-01-01

    Visible persistence refers to the continuation of visual perception after the physical termination of a stimulus. We studied an extreme case of visible persistence by presenting two matrices of randomly distributed black and white pixels in succession. On the transition from one matrix to the second, the luminance polarity of all pixels within a disk- or annulus-shaped area reversed, physically creating a single second-order transient signal. This transient signal produces the percept of a disk or an annulus with an abrupt onset and a gradual offset. To study the nature of this fading percept we varied spatial parameters, such as the inner and the outer diameter of annuli (Experiment I) and the radius and eccentricity of disks (Experiment III), and measured the duration of visible persistence by having subjects adjust the synchrony of the onset of a reference stimulus with the onset or the offset of the fading percept. We validated this method by comparing two modalities of the reference stimuli (Experiment I) and by comparing the judgments of fading percepts with the judgments of stimuli that actually fade in luminance contrast (Experiment II). The results show that (i) irrespective of the reference modality, participants are able to precisely judge the on- and the offsets of the fading percepts, (ii) auditory reference stimuli lead to higher visible persistence durations than visual ones, (iii) visible persistence duration increases with the thickness of annuli and the diameter of disks, but decreases with the diameter of annuli, irrespective of stimulus eccentricity. These effects cannot be explained by stimulus energy, which suggests that more complex processing mechanisms are involved. Seemingly contradictory effects of disk and annulus diameter can be unified by assuming an abstract filling-in mechanism that speeds up with the strength of the edge signal and takes more time the larger the stimulus area is. PMID:26348616

  6. Solution-processed single-walled carbon nanotube field effect transistors and bootstrapped inverters for disintegratable, transient electronics

    SciTech Connect

    Jin, Sung Hun E-mail: jhl@snu.ac.kr Shin, Jongmin; Cho, In-Tak; Lee, Jong-Ho E-mail: jhl@snu.ac.kr; Han, Sang Youn; Lee, Dong Joon; Lee, Chi Hwan; Rogers, John A. E-mail: jhl@snu.ac.kr

    2014-07-07

    This paper presents materials, device designs, and physical/electrical characteristics of a form of nanotube electronics that is physically transient, in the sense that all constituent elements dissolve and/or disperse upon immersion into water. Studies of contact effects illustrate the ability to use water soluble metals such as magnesium for source/drain contacts in nanotube based field effect transistors. High mobilities and on/off ratios in transistors that use molybdenum, silicon nitride, and silicon oxide enable full swing characteristics for inverters at low voltages (∼5 V) and with high gains (∼30). Dissolution/disintegration tests of such systems on water soluble sheets of polyvinyl alcohol demonstrate physical transience within 30 min.

  7. Heavy ion induced Single Event Phenomena (SEP) data for semiconductor devices from engineering testing

    NASA Technical Reports Server (NTRS)

    Nichols, Donald K.; Huebner, Mark A.; Price, William E.; Smith, L. S.; Coss, James R.

    1988-01-01

    The accumulation of JPL data on Single Event Phenomena (SEP), from 1979 to August 1986, is presented in full report format. It is expected that every two years a supplement report will be issued for the follow-on period. This data for 135 devices expands on the abbreviated test data presented as part of Refs. (1) and (3) by including figures of Single Event Upset (SEU) cross sections as a function of beam Linear Energy Transfer (LET) when available. It also includes some of the data complied in the JPL computer in RADATA and the SPACERAD data bank. This volume encompasses bipolar and MOS (CMOS and MHNOS) device data as two broad categories for both upsets (bit-flips) and latchup. It also includes comments on less well known phenomena, such as transient upsets and permanent damage modes.

  8. Compendium of Test Results of Recent Single Event Effect Tests Conducted by the Jet Propulsion Laboratory

    NASA Technical Reports Server (NTRS)

    McClure, Steven S.; Allen, Gregory R.; Irom, Farokh; Scheick, Leif Z.; Adell, Philippe C.; Miyahira, Tetsuo F.

    2010-01-01

    This paper reports heavy ion and proton-induced single event effect (SEE) results from recent tests for a variety of microelectronic devices. The compendium covers devices tested over the last two years by the Jet Propulsion Laboratory.

  9. System level latchup mitigation for single event and transient radiation effects on electronics

    SciTech Connect

    Kimbrough, J.R.; Colella, N.J.

    1994-12-31

    A `blink` technique, analogous to a person blinking at a flash of bright light, is provided for mitigating the effects of single event current latchup and prompt pulse destructive radiation on a micro-electronic circuit. The system includes event detection means, power dump logic means, and energy limiting measures with autonomous recovery. The event detection means includes ionizing radiation pulse detection means for detecting a pulse of ionizing radiation and for providing at an output terminal thereof a detection signal indicative of the detection of a pulse of ionizing radiation or by ion-induced destructive latchup of a semiconductor device. The current sensing means is coupled to the power bus for determining an occurrence of excess current through the power bus caused by ionizing radiation. The power dump means includes power dump logic means having a first input terminal connected to the output terminal of the ionizing radiation pulse detection means and having a second input terminal connected to the output terminal of the current sensing means. The power dump logic means provides an output signal to the input terminal of the means for opening the power bus and the means for shorting the power bus to a ground potential to remove power from the power bus. The energy limiting mean with autonomous recovery includes means for opening the power bus and means for shorting the power bus to a ground potential. The means for opening the power bus and means for shorting the power bus to a ground potential includes a series FET and a shunt FET. The invention provides for self-contained sensing for latchup, first removal of power to protect latched components, and autonomous recovery to enable transparent operation of other system elements.

  10. System level latchup mitigation for single event and transient radiation effects on electronics

    DOEpatents

    Kimbrough, Joseph Robert; Colella, Nicholas John

    1997-01-01

    A "blink" technique, analogous to a person blinking at a flash of bright light, is provided for mitigating the effects of single event current latchup and prompt pulse destructive radiation on a micro-electronic circuit. The system includes event detection circuitry, power dump logic circuitry, and energy limiting measures with autonomous recovery. The event detection circuitry includes ionizing radiation pulse detection means for detecting a pulse of ionizing radiation and for providing at an output terminal thereof a detection signal indicative of the detection of a pulse of ionizing radiation. The current sensing circuitry is coupled to the power bus for determining an occurrence of excess current through the power bus caused by ionizing radiation or by ion-induced destructive latchup of a semiconductor device. The power dump circuitry includes power dump logic circuitry having a first input terminal connected to the output terminal of the ionizing radiation pulse detection circuitry and having a second input terminal connected to the output terminal of the current sensing circuitry. The power dump logic circuitry provides an output signal to the input terminal of the circuitry for opening the power bus and the circuitry for shorting the power bus to a ground potential to remove power from the power bus. The energy limiting circuitry with autonomous recovery includes circuitry for opening the power bus and circuitry for shorting the power bus to a ground potential. The circuitry for opening the power bus and circuitry for shorting the power bus to a ground potential includes a series FET and a shunt FET. The invention provides for self-contained sensing for latchup, first removal of power to protect latched components, and autonomous recovery to enable transparent operation of other system elements.

  11. System level latchup mitigation for single event and transient radiation effects on electronics

    DOEpatents

    Kimbrough, J.R.; Colella, N.J.

    1997-09-30

    A ``blink`` technique, analogous to a person blinking at a flash of bright light, is provided for mitigating the effects of single event current latchup and prompt pulse destructive radiation on a micro-electronic circuit. The system includes event detection circuitry, power dump logic circuitry, and energy limiting measures with autonomous recovery. The event detection circuitry includes ionizing radiation pulse detection means for detecting a pulse of ionizing radiation and for providing at an output terminal thereof a detection signal indicative of the detection of a pulse of ionizing radiation. The current sensing circuitry is coupled to the power bus for determining an occurrence of excess current through the power bus caused by ionizing radiation or by ion-induced destructive latchup of a semiconductor device. The power dump circuitry includes power dump logic circuitry having a first input terminal connected to the output terminal of the ionizing radiation pulse detection circuitry and having a second input terminal connected to the output terminal of the current sensing circuitry. The power dump logic circuitry provides an output signal to the input terminal of the circuitry for opening the power bus and the circuitry for shorting the power bus to a ground potential to remove power from the power bus. The energy limiting circuitry with autonomous recovery includes circuitry for opening the power bus and circuitry for shorting the power bus to a ground potential. The circuitry for opening the power bus and circuitry for shorting the power bus to a ground potential includes a series FET and a shunt FET. The invention provides for self-contained sensing for latchup, first removal of power to protect latched components, and autonomous recovery to enable transparent operation of other system elements. 18 figs.

  12. Pressure-Fed LOX/LCH4 Reaction Control System for Spacecraft: Transient Modeling and Thermal Vacuum Hotfire Test Results

    NASA Technical Reports Server (NTRS)

    Atwell, Matthew J.; Hurlbert, Eric A.; Melcher, J. C.; Morehead, Robert L.

    2017-01-01

    An integrated cryogenic liquid oxygen, liquid methane (LOX/LCH4) reaction control system (RCS) was tested at NASA Glenn Research Center's Plum Brook Station in the Spacecraft Propulsion Research Facility (B-2) under vacuum and thermal vacuum conditions. The RCS is a subsystem of the Integrated Cryogenic Propulsion Test Article (ICPTA), a pressure-fed LOX/LCH4 propulsion system composed of a single 2,800 lbf main engine, two 28 lbf RCS engines, and two 7 lbf RCS engines. Propellants are stored in four 48 inch diameter 5083 aluminum tanks that feed both the main engine and RCS engines in parallel. Helium stored cryogenically in a composite overwrapped pressure vessel (COPV) flows through a heat exchanger on the main engine before being used to pressurize the propellant tanks to a design operating pressure of 325 psi. The ICPTA is capable of simultaneous main engine and RCS operation. The RCS engines utilize a coil-on-plug (COP) ignition system designed for operation in a vacuum environment, eliminating corona discharge issues associated with a high voltage lead. There are two RCS pods on the ICPTA, with two engines on each pod. One of these two engines is a heritage flight engine from Project Morpheus. Its sea level nozzle was removed and replaced by an 85:1 nozzle machined using Inconel 718, resulting in a maximum thrust of 28 lbf under altitude conditions. The other engine is a scaled down version of the 28 lbf engine, designed to match the core and overall mixture ratios as well as other injector characteristics. This engine can produce a maximum thrust of 7 lbf with an 85:1 nozzle that was additively manufactured using Inconel 718. Both engines are film-cooled and capable of limited duration gas-gas and gas-liquid operation, as well as steady-state liquid-liquid operation. Each pod contains one of each version, such that two engines of the same thrust level can be fired as a couple on opposite pods. The RCS feed system is composed of symmetrical 3/8 inch lines

  13. Efficient electromigration testing with a single current source

    NASA Astrophysics Data System (ADS)

    Kim, Choong-Un; Michael, N. L.; Jiang, Qing-Tang; Augur, Rod

    2001-10-01

    This article introduces a simple and effective technique for conducting electromigration testing of a number of samples using a single current source. It is based on a configuration where all samples are serially connected to a single current source, allowing them to be subjected to identical current conditions. In this design, each sample has a current bypass circuit, consisting essentially of a computer controlled shunt relay and a Zener diode, to enable continuation of testing without any interruption in the test current when samples fail. With this technique, a large number of samples can be tested with the same current and excellent current stability, making it suitable for both reliability assessment and scientific investigation of electromigration mechanisms. Initial results show high correlation with industry standard testing systems.

  14. Comparative research on “high currents” induced by single event latch-up and transient-induced latch-up

    NASA Astrophysics Data System (ADS)

    Chen, Rui; Han, Jian-Wei; Zheng, Han-Sheng; Yu, Yong-Tao; Shangguang, Shi-Peng; Feng, Guo-Qiang; Ma, Ying-Qi

    2015-04-01

    By using the pulsed laser single event effect facility and electro-static discharge (ESD) test system, the characteristics of the “high current”, relation with external stimulus and relevance to impacted modes of single event latch-up (SEL) and transient-induced latch-up (TLU) are studied, respectively, for a 12-bit complementary metal-oxide semiconductor (CMOS) analog-to-digital converter. Furthermore, the sameness and difference in physical mechanism between “high current” induced by SEL and that by TLU are disclosed in this paper. The results show that the minority carrier diffusion in the PNPN structure of the CMOS device which initiates the active parasitic NPN and PNP transistors is the common reason for the “high current” induced by SEL and for that by TLU. However, for SEL, the minority carrier diffusion is induced by the ionizing radiation, and an underdamped sinusoidal voltage on the supply node (the ground node) is the cause of the minority carrier diffusion for TLU. Project supported by the National Natural Science Foundation of China (Grant No. 41304148).

  15. SINGLE EVENT EFFECTS TEST FACILITY AT OAK RIDGE NATIONAL LABORATORY

    SciTech Connect

    Riemer, Bernie; Gallmeier, Franz X; Dominik, Laura J

    2015-01-01

    Increasing use of microelectronics of ever diminishing feature size in avionics systems has led to a growing Single Event Effects (SEE) susceptibility arising from the highly ionizing interactions of cosmic rays and solar particles. Single event effects caused by atmospheric radiation have been recognized in recent years as a design issue for avionics equipment and systems. To ensure a system meets all its safety and reliability requirements, SEE induced upsets and potential system failures need to be considered, including testing of the components and systems in a neutron beam. Testing of ICs and systems for use in radiation environments requires the utilization of highly advanced laboratory facilities that can run evaluations on microcircuits for the effects of radiation. This paper provides a background of the atmospheric radiation phenomenon and the resulting single event effects, including single event upset (SEU) and latch up conditions. A study investigating requirements for future single event effect irradiation test facilities and developing options at the Spallation Neutron Source (SNS) is summarized. The relatively new SNS with its 1.0 GeV proton beam, typical operation of 5000 h per year, expertise in spallation neutron sources, user program infrastructure, and decades of useful life ahead is well suited for hosting a world-class SEE test facility in North America. Emphasis was put on testing of large avionics systems while still providing tunable high flux irradiation conditions for component tests. Makers of ground-based systems would also be served well by these facilities. Three options are described; the most capable, flexible, and highest-test-capacity option is a new stand-alone target station using about one kW of proton beam power on a gas-cooled tungsten target, with dual test enclosures. Less expensive options are also described.

  16. Study on the test of transient ultraviolet spectrum for remote extended area sources with spectrometer

    NASA Astrophysics Data System (ADS)

    Li, Hongguang; Yang, Hongru; Wu, Baoning; Chang, Weijun; Bai, Zhao; Yin, Qingyan

    2010-10-01

    Spectral radiation intensity measurement at ultraviolet wavelengths is important for the material composition analysis of transient extended area light sources. Here we developed transient ultraviolet multi-spectral spectrometer which is utilized to measure relative spectral radiation intensity distributions of remote transient as well as steady-state extended area light sources in the wavelength range (0.22-0.40) μm. Simultaneously the device also shows different spectral radiation intensity distribution curve of the transient radiation source along with time changes. This spectrometer consists of mobile collimation lens, Cassegrain imaging system, grating spectrograph, high speed data acquisition system and computer software. Since ultraviolet spectral radiation is severely absorbed in air transmission, firstly the Cassegrain system which has high reflectance in ultraviolet wavelength range is used to image the extended area light source onto the entrance slit of spectrograph, in order to markedly improve the light gathering power of the device. The spectrograph uses plane blazed grating to disperse spectrums which are focalized as the focal plane for detection by ultraviolet response enhancing array CCD detector. Secondly, to resolve spectrum acquisition problem of nanosecond transient light sources, we adopt CCD drive technology programmed by CPLD and fixed phasic high speed data acquisition method. Finally, the spectral distortion of the spectrograph is reduced by using non-parametric kernel regression de-noising algorithm and convolution algorithm in order to improve the spectral resolving power of the device. So we experimentalize for spectral radiation intensity distributions of remote transient and steady-state extended area light sources, then the uncertainty of measurement results is analyzed.

  17. High Power Tests of Normal Conducting Single-Cell Structures

    SciTech Connect

    Dolgashev, V.A.; Tantawi, S.G.; Nantista, C.D.; Higashi, Y.; Higo, T.; /KEK, Tsukuba

    2007-11-07

    We report the results of the first high power tests of single-cell traveling-wave and standing-wave structures. These tests are part of an experimental and theoretical study of rf breakdown in normal conducting structures at 11.4 GHz. The goal of this study is to determine the gradient potential of normal-conducting rf-powered particle beam accelerators. The test setup consists of reusable mode converters and short test structures and is powered by SLAC's XL-4 klystron. This setup was created for economical testing of different cell geometries, cell materials and preparation techniques with short turn-around time. The mode launchers and structures were manufactured at SLAC and KEK and tested in the SLAC Klystron Test Lab.

  18. Routine and Recurring Small Transient and New Test Missions Environmental Assessment

    DTIC Science & Technology

    2008-04-01

    95th Air Base Wing Environmental Management Directorate Edwards Air Force Base, California Report Documentation Page Form... California proposes to add up to 25 aircraft, 2000 sorties per year, and 1500 military, government civilian, and contractor personnel to support small...SIGNIFICANT IMPACT (FONSI) FOR ROUTINE AND RECURRING SMALL TRANSIENT AND NEW SMALL MISSIONS ENVIRONMENTAL ASSESSMENT 1.0 INTRODUCTION The Air Force

  19. Transient Hypothyroidism after Radioiodine for Graves' Disease: Challenges in Interpreting Thyroid Function Tests.

    PubMed

    Sheehan, Michael T; Doi, Suhail A R

    2016-03-01

    Graves' disease is the most common cause of hyperthyroidism and is often managed with radioactive iodine (RAI) therapy. With current dosing schemes, the vast majority of patients develop permanent post-RAI hypothyroidism and are placed on life-long levothyroxine therapy. This hypothyroidism typically occurs within the first 3 to 6 months after RAI therapy is administered. Indeed, patients are typically told to expect life-long thyroid hormone replacement therapy to be required within this timeframe and many providers expect this post-RAI hypothyroidism to be complete and permanent. There is, however, a small subset of patients in whom a transient post-RAI hypothyroidism develops which, initially, presents exactly as the typical permanent hypothyroidism. In some cases the transient hypothyroidism leads to a period of euthyroidism of variable duration eventually progressing to permanent hypothyroidism. In others, persistent hyperthyroidism requires a second dose of RAI. Failure to appreciate and recognize the possibility of transient post-RAI hypothyroidism can delay optimal and appropriate treatment of the patient. We herein describe five cases of transient post-RAI hypothyroidism which highlight this unusual sequence of events. Increased awareness of this possible outcome after RAI for Graves' disease will help in the timely management of patients.

  20. Outbreak of Transient Conversions of the QuantiFERON-TB Gold In-Tube Test in Laboratory Health Care Worker Screenings

    PubMed Central

    Peracchi, Marta; Zorzi, Diego; Fiorio, Silvia; Fallico, Loredana; Palù, Giorgio

    2012-01-01

    Gamma interferon release assays were recently introduced in health care worker (HCWs) screenings for tuberculosis surveillance. In longitudinal surveys, conversions and reversions are seen, and yet whether these changes are unspecific or are an expression of new infections and microbial clearance remains unclear. In order to further elucidate these changes, we analyzed an outbreak of 15 transient conversions in 53 HCWs who operate in the same laboratory and handle specimens potentially containing Mycobacterium tuberculosis who underwent screening by the QuantiFERON-TB Gold In-Tube (QFT-GIT) test between 11 May and 30 June 2010: 15/46 (33%) negative HCWs showed a conversion and then reverted after 7 to 107 days. To validate these results, an evaluation of methodological procedures and test reliability, as well as an analysis of results obtained during the same period and processed by the same laboratory, was carried out. For the latter purpose, QFT-GIT results determined for 78 ward HCWs who underwent screening during the same period and were employed in departments with at least 3 infectious tuberculosis patients per year or had cared for an infectious patient without airborne precautions were analyzed with the following results: 6/63 (9%) HCWs with negative results in 3 different departments showed transient conversion (P = 0.002; odds ratio, 4.60; 95% confidence interval, 1.62 to 13.04). A retrospective survey of in-house biosafety practices led to determination of a single exposure factor within the laboratory. These data emphasize the validity of the hypothesis that a transient conversion demonstrates the presence of a real tubercular infection and could be an important indicator for occupational biosafety concerns. They also confirm that subjects with recent conversion should be retested before chest radiography and chemotherapy is offered. PMID:22518010

  1. Global nuclear energy partnership fuels transient testing at the Sandia National Laboratories nuclear facilities : planning and facility infrastructure options.

    SciTech Connect

    Kelly, John E.; Wright, Steven Alan; Tikare, Veena; MacLean, Heather J.; Parma, Edward J., Jr.; Peters, Curtis D.; Vernon, Milton E.; Pickard, Paul S.

    2007-10-01

    The Global Nuclear Energy Partnership fuels development program is currently developing metallic, oxide, and nitride fuel forms as candidate fuels for an Advanced Burner Reactor. The Advance Burner Reactor is being designed to fission actinides efficiently, thereby reducing the long-term storage requirements for spent fuel repositories. Small fuel samples are being fabricated and evaluated with different transuranic loadings and with extensive burnup using the Advanced Test Reactor. During the next several years, numerous fuel samples will be fabricated, evaluated, and tested, with the eventual goal of developing a transmuter fuel database that supports the down selection to the most suitable fuel type. To provide a comparative database of safety margins for the range of potential transmuter fuels, this report describes a plan to conduct a set of early transient tests in the Annular Core Research Reactor at Sandia National Laboratories. The Annular Core Research Reactor is uniquely qualified to perform these types of tests because of its wide range of operating capabilities and large dry central cavity which extents through the center of the core. The goal of the fuels testing program is to demonstrate that the design and fabrication processes are of sufficient quality that the fuel will not fail at its design limit--up to a specified burnup, power density, and operating temperature. Transient testing is required to determine the fuel pin failure thresholds and to demonstrate that adequate fuel failure margins exist during the postulated design basis accidents.

  2. Single Event Effect microchip testing at the Texas A&M University Cyclotron Institute

    NASA Astrophysics Data System (ADS)

    Clark, Henry; Yennello, Sherry; Texas A&M University-Cyclotron Institute Team

    2015-10-01

    A Single Event Effect (SEE) is caused by a single, energetic particle that deposits a sufficient amount of charge in a device as it transverses it and upsets its normal operation. Soft errors are non-destructive and normally appear as transient pulses in logic or support circuitry, or as bit flips in memory cells or registers. Hard errors usually result in a high operating current, above device specifications, and must be cleared by a power reset. Burnout errors are so destructive that the device becomes operationally dead. Spacecraft designers must be concerned with the causes of SEE's from protons and heavy ions since commercial devices are typically chosen reduce the parameters of power, weight, volume and cost but have increased functionality, which in turn are typically vulnerable to SEE. As a result all mission-critical devices must be tested. The TAMU K500 superconducting cyclotron has provided beams for space radiation testing since 1994. Starting at just 100 hours/year at inception, the demand has grown to 3000 hours/year. In recent years, most beam time has been for US defense system testing. Nearly 15% has been provided for foreign agencies from Europe and Asia. An overview of the testing facility and future plans will be presented.

  3. Axisymmetric Granular Collapse: A Transient 3D Flow Test of Viscoplasticity

    NASA Astrophysics Data System (ADS)

    Lacaze, Laurent; Kerswell, Rich R.

    2009-03-01

    A viscoplastic continuum theory has recently been proposed to model dense, cohesionless granular flows [P. Jop , Nature (London)NATUAS0028-0836 441, 727 (2006)10.1038/nature04801]. We confront this theory for the first time with a transient, three-dimensional flow situation—the simple collapse of a cylinder of granular matter onto a horizontal plane—by extracting stress and strain rate tensors directly from soft particle simulations. These simulations faithfully reproduce the different flow regimes and capture the observed scaling laws for the final deposit. Remarkably, the theoretical hypothesis that there is a simple stress-strain rate tensorial relationship does seem to hold across the whole flow even close to the rough boundary provided the flow is dense enough. These encouraging results suggest viscoplastic theory is more generally applicable to transient, multidirectional, dense flows and open the way for quantitative predictions in real applications.

  4. Response to the comment by Mesut Cimen on ;Depth-discrete specific storage in fractured sedimentary rock using steady-state and transient single-hole hydraulic tests; by Patryk M. Quinn, John A. Cherry, Beth L. Parker, J. Hydrol. 542 (2016), Journal of Hydrology, Volume 546, March 2017, 14-15

    NASA Astrophysics Data System (ADS)

    Quinn, P.; Cherry, J.; Parker, B.

    2017-04-01

    We thank Dr. Cimen for his thoughts and comments on the above paper. We understand his comments provide the following main points: Estimation of aquifer parameters depends on the matching of observation data to the theoretical response, and in the constant rate injection and withdrawal test presented in our paper (C6 zone 17) there is not a good fit between the theoretical and observed drawdowns. He proposes that the poor fit is caused by well losses. Although Dr. Cimen has not defined what he means by 'well losses', for clarity here we provide the definition from Walton (1987): One of the components of drawdown in a production well is well loss due to the turbulent flow of water through the well face and inside the casing…

  5. Experimental Test of Nonclassicality for a Single Particle

    DTIC Science & Technology

    2008-08-01

    R. Y. Chiao, “Correlated two-photon interference in a dual-beam Michelson interferometer ,” Phys. Rev. A 41, 2910-2913 (1990). 9. T. E. Kiess, Y. H...M. D. Eisaman, E. A. Goldschmidt, J. Chen, J. Fan, and A. Migdall, “Experimental test of nonlocal realism using a fiber -based source of polarization...experiment, photons in the heralding arm are routed by a single-mode fiber (SMF) to a Si-single-photon Avalanche Diode (SPAD) operating in Geiger mode, while

  6. Bulge testing of single- and dual-layer thin films

    NASA Astrophysics Data System (ADS)

    Huston, Dryver R.; Sauter, Wolfgang; Bunt, Patricia S.; Esser, Brian

    2001-08-01

    The bulge testing technique determines the mechanical properties of solid thin films by measuring the deformation that forms in response to the application of a controlled differential pressure to a thin film window. By comparing the pressure-displacement relation with a mechanical model, the elastic modulus and residual stress in the film can be measured. While the bulge testing technique can be quite effective, the technique is not routinely used because of difficulties that often arise with using this technique. The difficulties include specimen preparation and mounting, automated bulge height measurement and the correlation of bulge deformation with the mechanical properties of the thin film. This paper describes developments in the bulge testing technique that alleviate many of these difficulties, as well as presenting results from the testing of single and dual layer thin films. Single film tests were conducted on samples of B-doped-Si, SiC, and diamond-like carbon. A total of 135 windows with three different window aspect ratios and two different thicknesses were investigated. In a preliminary study to determine the feasibility of extending the technique to the testing of multilayer films, the mechanics of a dual layer system were measured. The dual layer system was an Al layer on top of B-doped-Si. The results from the single film test were that the elastic moduli of the B-doped-Si were close to nominal bulk values and the diamond-like carbon was about half that of diamond. The SiC elastic moduli measurements were inconclusive because of the large prestress. Elastic moduli measurements from nanoindentation were about 50% higher. It should be noted that neither the variation of the aspect ratio nor the variation of the film thickness led to different results. The measured prestresses agreed quite well with wafer curvature measurement. The dual-layer measurements yielded values for the elastic modulus of thin film Al that were within 5% of the nominal bulk

  7. Modelling and optimization of transient processes in line focusing power plants with single-phase heat transfer medium

    NASA Astrophysics Data System (ADS)

    Noureldin, K.; González-Escalada, L. M.; Hirsch, T.; Nouri, B.; Pitz-Paal, R.

    2016-05-01

    A large number of commercial and research line focusing solar power plants are in operation and under development. Such plants include parabolic trough collectors (PTC) or linear Fresnel using thermal oil or molten salt as the heat transfer medium (HTM). However, the continuously varying and dynamic solar condition represent a big challenge for the plant control in order to optimize its power production and to keep the operation safe. A better understanding of the behaviour of such power plants under transient conditions will help reduce defocusing instances, improve field control, and hence, increase the energy yield and confidence in this new technology. Computational methods are very powerful and cost-effective tools to gain such understanding. However, most simulation models described in literature assume equal mass flow distributions among the parallel loops in the field or totally decouple the flow and thermal conditions. In this paper, a new numerical model to simulate a whole solar field with single-phase HTM is described. The proposed model consists of a hydraulic part and a thermal part that are coupled to account for the effect of the thermal condition of the field on the flow distribution among the parallel loops. The model is specifically designed for large line-focusing solar fields offering a high degree of flexibility in terms of layout, condition of the mirrors, and spatially resolved DNI data. Moreover, the model results have been compared to other simulation tools, as well as experimental and plant data, and the results show very good agreement. The model can provide more precise data to the control algorithms to improve the plant control. In addition, short-term and accurate spatially discretized DNI forecasts can be used as input to predict the field behaviour in-advance. In this paper, the hydraulic and thermal parts, as well as the coupling procedure, are described and some validation results and results of simulating an example field are

  8. FOREVER ALONE? TESTING SINGLE ECCENTRIC PLANETARY SYSTEMS FOR MULTIPLE COMPANIONS

    SciTech Connect

    Wittenmyer, Robert A.; Horner, Jonathan; Tinney, C. G.; Bailey, J.; Salter, G. S.; Wright, D.; Wang Songhu; Zhou Jilin; Butler, R. P.; Jones, H. R. A.; O'Toole, S. J.; Carter, B. D.

    2013-09-15

    Determining the orbital eccentricity of an extrasolar planet is critically important for understanding the system's dynamical environment and history. However, eccentricity is often poorly determined or entirely mischaracterized due to poor observational sampling, low signal-to-noise, and/or degeneracies with other planetary signals. Some systems previously thought to contain a single, moderate-eccentricity planet have been shown, after further monitoring, to host two planets on nearly circular orbits. We investigate published apparent single-planet systems to see if the available data can be better fit by two lower-eccentricity planets. We identify nine promising candidate systems and perform detailed dynamical tests to confirm the stability of the potential new multiple-planet systems. Finally, we compare the expected orbits of the single- and double-planet scenarios to better inform future observations of these interesting systems.

  9. Coincident steam generator tube rupture and stuck-open safety relief valve carryover tests: MB-2 steam generator transient response test program

    SciTech Connect

    Garbett, K; Mendler, O J; Gardner, G C; Garnsey, R; Young, M Y

    1987-03-01

    In PWR steam generator tube rupture (SGTR) faults, a direct pathway for the release of radioactive fission products can exist if there is a coincident stuck-open safety relief valve (SORV) or if the safety relief valve is cycled. In addition to the release of fission products from the bulk steam generator water by moisture carryover, there exists the possibility that some primary coolant may be released without having first mixed with the bulk water - a process called primary coolant bypassing. The MB-2 Phase II test program was designed specifically to identify the processes for droplet carryover during SGTR faults and to provide data of sufficient accuracy for use in developing physical models and computer codes to describe activity release. The test program consisted of sixteen separate tests designed to cover a range of steady-state and transient fault conditions. These included a full SGTR/SORV transient simulation, two SGTR overfill tests, ten steady-state SGTR tests at water levels ranging from very low levels in the bundle up to those when the dryer was flooded, and three moisture carryover tests without SGTR. In these tests the influence of break location and the effect of bypassing the dryer were also studied. In a final test the behavior with respect to aerosol particles in a dry steam generator, appropriate to a severe accident fault, was investigated.

  10. Single particle friction tests with cellulose acetate sphere samples

    SciTech Connect

    Tuezen, U.

    1989-05-31

    This reporter represents a detailed account of all the experimental work carried out for LLNL using the ''single particle shear cell'' in the department of Chemical Process Engineering of Surrey University, Guildford, United Kingdom. Experimental work with two spheres in contact was performed. Particles were positioned into the specially made sample holders by the micro screws. The contact centres were lined up under the magnifying glass. The behavior of the interparticle contact region between the two spheres was examined by performing the following series of tests: (i) normal force versus normal displacement test, (ii) tangential force limit at gross sliding with increased normal load and decreasing normal load, (iii) tangential force versus micro displacement during initial loading to friction limit and during unloading from friction limit. Work was also performed on single sphere against a flat wall surface. Results are discussed. 34 figs.

  11. An entropy test for single-locus genetic association analysis

    PubMed Central

    2010-01-01

    , since many researchers tend to discard low allele-frequency SNPs from their analysis. Now they can apply the same statistical test of association to all SNPs in a single analysis., which can be especially helpful to detect rare effects. PMID:20331859

  12. Qualified testing of single-locus codominant inheritance using single tree progenies.

    PubMed

    Gillet, E M; Gregorius, H R

    2000-09-01

    In forest trees, classical techniques of studying modes of inheritance are usually not feasible due to the difficulty of performing controlled crosses. The limited information on inheritance extractable from readily available data, such as the large progenies collectable from single seed trees, must be compensated by the design of appropriately parameterized models. For this purpose, a system analytic approach is used to develop a new inferential framework for testing a single-locus codominant mode of inheritance of genetic traits using the inferred genotypes within progenies of single trees of inferred heterozygous genotype. Model assumptions are random gametic fusion between the local gamete pools and absence of postzygotic selection; ovule segregation distortion is allowed. The method yields estimates of the allele frequencies in both local gamete pools. Since tests of modes of inheritance must be tests of models rather than of parameters, the utility of the classical statistical testing procedures is limited, particularly concerning the qualification of a sampling method to attain a preassigned level of precision. Consistent application of this principle makes it possible to design qualified sampling methods prior to the actual experiment as well as to specify qualification levels for tests of completed experiments.

  13. TRAVELLING WAVE AND STANDING WAVE SINGLE CELL HIGH GRADIENT TESTS

    SciTech Connect

    Dolgashev, V

    2004-08-24

    Accelerating gradient is one of the crucial parameters affecting design, construction and cost of next-generation linear accelerators. Operating accelerating gradient in normal conducting accelerating structures is limited by rf breakdown. In this paper we describe an experimental setup for study of these limits for 11.4 GHz travelingwave and standing-wave accelerating structures. The setup uses matched mode converters that launch the circular TM01 mode into short test structures. The test structures are designed so that the electromagnetic fields in one cell mimic the fields in prototype structures for the Next Linear Collider. Fields elsewhere in the test structures and in the mode converters are significantly lower than in this single cell. This setup allows economic testing of different cell geometries, cell materials and preparation techniques with short turn around time. Here we present design considerations and describe planned experiments.

  14. Single-qubit tests of Bell-like inequalities

    SciTech Connect

    Zela, F. de

    2007-10-15

    This paper discusses some tests of Bell-like inequalities not requiring entangled states. The proposed tests are based on consecutive measurements on a single qubit. Available hidden-variable models for a single qubit [see, e.g., J. S. Bell, Rev. Mod. Phys. 38, 447 (1966)] reproduce the predictions of quantum mechanics and hence violate the Bell-like inequalities addressed in this paper. It is shown how this fact is connected with the state 'collapse' and with its random nature. Thus, it becomes possible to test truly realistic and deterministic hidden-variable models. In this way, it can be shown that a hidden-variable model should entail at least one of the following features: (i) nonlocality, (ii) contextuality, or (iii) discontinuous measurement-dependent probability functions. The last two features are put to the test with the experiments proposed in this paper. A hidden-variable model that is noncontextual and deterministic would be at variance with some predictions of quantum mechanics. Furthermore, the proposed tests are more likely to be loophole-free, as compared to former ones.

  15. Transient Plume Model Testing Using LADEE Spacecraft Attitude Control System Operations

    NASA Technical Reports Server (NTRS)

    Woronowicz, Michael

    2011-01-01

    We have learned it is conceivable that the Neutral Mass Spectrometer on board the Lunarr Atmosphere Dust Environment Explorer (LADEE) could measure gases from surface-reflected Attitude Control System (ACS) thruster plume. At minimum altitude, the measurement would be maximized, and gravitational influence minimized ("short" time-of-flight (TOF) situation) Could use to verify aspects of thruster plume modeling Model the transient disturbance to NMS measurements due to ACS gases reflected from lunar surface Observe evolution of various model characteristics as measured by NMS Species magnitudes, TOF measurements, angular distribution, species separation effects

  16. Cultural Resource Investigations for the Resumption of Transient Testing of Nuclear Fuels and Material at the Idaho National Laboratory

    SciTech Connect

    Brenda R. Pace; Julie B. Williams

    2013-11-01

    The U. S. Department of Energy (DOE) has a need to test nuclear fuels under conditions that subject them to short bursts of intense, high-power radiation called ‘transient testing’ in order to gain important information necessary for licensing new nuclear fuels for use in U.S. nuclear power plants, for developing information to help improve current nuclear power plant performance and sustainability, for improving the affordability of new generation reactors, for developing recyclable nuclear fuels, and for developing fuels that inhibit any repurposing into nuclear weapons. To meet this mission need, DOE is considering alternatives for re-use and modification of existing nuclear reactor facilities to support a renewed transient testing program. One alternative under consideration involves restarting the Transient Reactor Test (TREAT) reactor located at the Materials and Fuels Complex (MFC) on the Idaho National Laboratory (INL) site in southeastern Idaho. This report summarizes cultural resource investigations conducted by the INL Cultural Resource Management Office in 2013 to support environmental review of activities associated with restarting the TREAT reactor at the INL. These investigations were completed in order to identify and assess the significance of cultural resources within areas of potential effect associated with the proposed action and determine if the TREAT alternative would affect significant cultural resources or historic properties that are eligible for nomination to the National Register of Historic Places. No archaeological resources were identified in the direct area of potential effects for the project, but four of the buildings proposed for modifications are evaluated as historic properties, potentially eligible for nomination to the National Register of Historic Places. This includes the TREAT reactor (building #), control building (building #), guardhouse (building #), and warehouse (building #). The proposed re-use of these historic

  17. Measuring Criterion-Referenced Test Reliability with a Single Test Administration.

    ERIC Educational Resources Information Center

    Scheetz, James P.; vonFraunhofer, J. Anthony

    Subkoviak suggested a technique for estimating both group reliability and the reliability associated with assigning a given individual to a mastery or non-mastery category based on a single test administration. Two assumptions underlie this model. First, it is assumed that had successive test administrations occurred, scores for each individual…

  18. MCNP6 simulated performance of Micro-Pocket Fission Detectors (MPFDs) in the Transient REActor Test (TREAT) Facility

    DOE PAGES

    Reichenberger, Michael A.; Patel, Vishal K.; Roberts, Jeremy A.; ...

    2017-03-03

    Here, Micro-Pocket Fission Detectors (MPFDs) are under development for in-core neutron flux measurements at the Transient REActor Test facility (TREAT) and in other experiments at Idaho National Laboratory (INL). The sensitivity of MPFDs to the energy dependent neutron flux at TREAT has been determined for 0.0300-μm thick active material coatings of 242Pu, 232Th, natural uranium, and 93% enriched 235U. Self-shielding effects in the active material of the MPFD was also confirmed to be negligible. Finally, fission fragment energy deposition was found to be in conformance with previously reported results.

  19. CFD Simulations of Selected Steady-State and Transient Experiments in the PLANDTL Test Facility

    NASA Astrophysics Data System (ADS)

    Gurgacz, S.; Bieder, U.; Gorsse, Y.; Swirski, K.

    2016-09-01

    In Sodium Cooled Fast Neutron Reactors natural convection flow and thermal stratification in the upper plenum may occur under emergency shutdown conditions. Thermal stratification phenomena have been examined experimentally in the PLANDTL facility of the Japan Atomic Energy Agency. This paper presents the results of numerical simulations of selected steady-state and transient experiments in the PLANDTL facility, using TrioCFD/MC2 code developed at CEA. CFD approach for the flow in large volumes and a sub-channel approach for the flow in the core region are used. Calculated results have been validated against experimental values. Validation of the upper plenum modelling has been also made based on CEA Sodium mixed convection experiments.

  20. Methodology for measuring exhaust aerosol size distributions using an engine test under transient operating conditions

    NASA Astrophysics Data System (ADS)

    María Desantes, José; Bermúdez, Vicente; Molina, Santiago; Linares, Waldemar G.

    2011-11-01

    A study on the sources of variability in the measurement of particle size distribution using a two-stage dilution system and an engine exhaust particle sizer was conducted to obtain a comprehensive and repeatable methodology that can be used to measure the particle size distribution of aerosols emitted by a light-duty diesel engine under transient operating conditions. The paper includes three experimental phases: an experimental validation of the measurement method; an evaluation of the influence of sampling factors, such as dilution system pre-conditioning; and a study of the effects of the dilution conditions, such as the dilution ratio and the dilution air temperature. An examination of the type and degree of influence of each studied factor is presented, recommendations for reducing variability are given and critical parameter values are identified to develop a highly reliable measurement methodology that could be applied to further studies on the effect of engine operating parameters on exhaust particle size distributions.

  1. Implementation and Testing of the First Prompt Search for Gravitational Wave Transients with Electromagnetic Counterparts

    NASA Technical Reports Server (NTRS)

    Abadie, J.; Abbott, B. P.; Abbott, R.; Abbott, T. D.; Abernathy, M.; Accadia, T.; Acernese, F.; Adams, C.; Adhikari, R.; Affeldt, C.; Agathos, M.; Ajith, P.; Allen, B.; Allen, G. S.; Ceron, E. Amador; Amariutei, D.; Amin, R. S.; Anderson, S. B.; Anderson, W. G.; Araya, M. C.; Aston, S. M.; Astone, P.; Atkinson, D.; Aufmuth, P.; Blackburn, L.

    2012-01-01

    Aims. A transient astrophysical event observed in both gravitational wave (GW) and electromagnetic (EM) channels would yield rich scientific rewards. A first program initiating EM follow-ups to possible transient GW events has been developed and exercised by the LIGO and Virgo community in association with several partners. In this paper, we describe and evaluate the methods used to promptly identify and localize GW event candidates and to request images of targeted sky locations. Methods. During two observing periods (Dec. 17, 2009 to Jan. 8, 2010 and Sep. 2 to Oct. 20, 2010), a low-latency analysis pipeline was used to identify GW event candidates and to reconstruct maps of possible sky locations. A catalog of nearby galaxies and MilkyWay globular clusters was used to select the most promising sky positions to be imaged, and this directional information was delivered to EM observatories with time lags of about thirty minutes. A Monte Carlo simulation has been used to evaluate the low-latency GW pipeline's ability to reconstruct source positions correctly. Results. For signals near the detection threshold, our low-latency algorithms often localized simulated GW burst signals to tens of square degrees, while neutron star/neutron star inspirals and neutron star/black hole inspirals were localized to a few hundred square degrees. Localization precision improves for moderately stronger signals. The correct sky location of signals well above threshold and originating from nearby galaxies may be observed with 50% or better probability with a few pointings of wide-field telescopes.

  2. Implementation and Testing of the First Prompt for Electromagnetic Counterparts to Gravitational Wave Transients

    NASA Technical Reports Server (NTRS)

    Abadie, J.; Abbott, B. P.; Abbott, R.; Abbott, T. D.; Abernathy, M.; Accadia, T.; Acernese, F.; Adams, C.; Adhikari, R.; Affeldt, C.; Ajith, P.; Allen, B.; Allen, G. S.; Amador Ceron, E.; Amariutei, D.; Amin, R. S.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Arain, M. A.; Araya, M. C.; Blackburn, L.; Camp, J. B.; Cannizzo, J.; Gehrels, N.

    2011-01-01

    A transient astrophysical event observed in both gravitational wave (GW) and electromagnetic (EM) channels would yield rich scientific rewards. A first program initiating EM follow-ups to possible transient GW events has been developed and exercised by the LIGO and Virgo community in association with several partners. In this paper, we describe and evaluate the methods used to promptly identify and localize GW event candidates and to request images of targeted sky locations. Methods. During two observing periods (Dec 17 2009 to Jan 8 2010 and Sep 2 to Oct 20 2010), a low-latency analysis pipeline was used to identify GW-event candidates and to reconstruct-maps of possible sky locations. A catalog of nearby galaxies and Milky Way globular clusters was used to select the most promising sky positions to be imaged, and this directional information was delivered to EM observatories with time lags of about thirty minutes. A Monte Carlo simulation has been used to evaluate the low-latency GW pipeline s ability to reconstruct source positions correctly. Results. For signals near the detection threshold, our low-latency algorithms often localized simulated GW burst signals to tens of square degrees, while neutron star/neutron star inspirals and neutron star/black hole inspirals were localized to a few hundred square degrees. Localization precision improves for moderately stronger signals. The correct sky location of signals well above threshold and originating from nearby galaxies may be observed with 50% or better probability with a few pointings of wide-field telescopes.

  3. Constitutive modeling of superalloy single crystals with verification testing

    NASA Technical Reports Server (NTRS)

    Jordan, Eric; Walker, Kevin P.

    1985-01-01

    The goal is the development of constitutive equations to describe the elevated temperature stress-strain behavior of single crystal turbine blade alloys. The program includes both the development of a suitable model and verification of the model through elevated temperature-torsion testing. A constitutive model is derived from postulated constitutive behavior on individual crystallographic slip systems. The behavior of the entire single crystal is then arrived at by summing up the slip on all the operative crystallographic slip systems. This type of formulation has a number of important advantages, including the prediction orientation dependence and the ability to directly represent the constitutive behavior in terms which metallurgists use in describing the micromechanisms. Here, the model is briefly described, followed by the experimental set-up and some experimental findings to date.

  4. Classification of Transient Phenomena in Distribution System using wavelet Transform

    NASA Astrophysics Data System (ADS)

    Sedighi, Alireza

    2014-05-01

    An efficient procedure for classification of transient phenomena in distribution systems is proposed in this paper. The proposed method has been applied to classify some transient phenomena such as inrush current, load switching, capacitor switching and single phase to ground fault. The new scheme is based on wavelet transform algorithm. All of the events for feature extraction and test are simulated using Electro Magnetic Transient Program (EMTP). Results show high accuracy of proposed method.

  5. Raman scattering test of single-wall carbon nanotube composites

    NASA Astrophysics Data System (ADS)

    Hadjiev, V. G.; Iliev, M. N.; Arepalli, S.; Nikolaev, P.; Files, B. S.

    2001-05-01

    Raman spectroscopy is used to infer elastic properties of single-wall carbon nanotubes (SWNTs) in composites. This letter presents strain-induced frequency shift of tangential Raman active modes of SWNTs embedded in epoxy resin subjected to bending. Epoxy curing and sample extension in the tensile strength test are found to create residual strains on the SWNT ropes. We demonstrate that specimen compression in combination with the Raman microprobe technique provides a means for determining of these strains and hence load transfer effectiveness.

  6. Design, fabrication and testing of single spoke resonators at Fermilab

    SciTech Connect

    Ristori, L.; Apollinari, G.; Borissov, E.; Gonin, I.V.; Khabiboulline, T.N.; Mukherjee, A.; Nicol, T.H.; Ozelis, J.; Pischalnikov, Y.; Sergatskov, D.A.; Wagner, R.; /Fermilab

    2009-09-01

    The Fermilab High Intensity Neutrino Source (HINS) linac R&D program is building a pulsed 30 MeV superconducting H- linac. The linac incorporates superconducting solenoids, high power RF vector modulators and superconducting spoke-type accelerating cavities starting at 10 MeV. This will be the first application and demonstration of any of these technologies in a low-energy, high-intensity proton/H- linac. The HINS effort is relevant to a high intensity, superconducting H- linac that might serve the next generation of neutrino physics and muon storage ring/collider experiments. In this paper we present the RF design, the mechanical design, the fabrication, the chemistry and testing of the first two SSR1 (Single Spoke Resonator type-1) prototype cavities that were built. These cavities operate at 325 MHz with {beta} = 0.21. The design and testing of the input coupler and the tuning mechanism are also discussed.

  7. Dynamic acousto-elastic test using continuous probe wave and transient vibration to investigate material nonlinearity.

    PubMed

    Eiras, J N; Vu, Q A; Lott, M; Payá, J; Garnier, V; Payan, C

    2016-07-01

    This study demonstrates the feasibility of the dynamic acousto-elastic effect of a continuous high frequency wave for investigating the material nonlinearity upon transient vibration. The approach is demonstrated on a concrete sample measuring 15×15×60cm(3). Two ultrasonic transducers (emitter and receiver) are placed at its middle span. A continuous high frequency wave of 500kHz propagates through the material and is modulated with a hammer blow. The position of the hammer blow on the sample is configured to promote the first bending mode of vibration. The use of a continuous wave allows discrete time extraction of the nonlinear behavior by a short-time Fourier transform approach, through the simultaneous comparison of a reference non-modulated signal and an impact-modulated signal. The hammer blow results in phase shifts and variations of signal amplitude between reference and perturbed signals, which are driven by the resonant frequency of the sample. Finally, a comprehensive analysis of the relaxation mechanisms (modulus and attenuation recovery) is conducted to untangle the coupled fast and slow hysteretic effects.

  8. Development of the IM147: an alternative inspection/maintenance mass-emission transient test to address vehicle preconditioning concerns.

    PubMed

    Joy, Richard W; Heirigs, Philip L; Torgerson, Garrett D; St Denis, Michael; Austin, Thomas C; Gordon, Jay; Tefft, Bob; Lindner, Jim

    2004-03-01

    A series of studies was performed to develop an alternative to the U.S. Environmental Protection Agency's gold standard IM240 mass-based emission test. The new IM147 test was based on the second phase of the IM240 that consists of 147 sec of transient vehicle operation. Paired IM240/IM147 tests were conducted on vehicles ranging from 1981 to 1996 to determine IM147 cutpoints and excess emissions were identified. Additionally, an optimized test procedure was developed that combined possible triplicate IM147s with improved drive trace quality control, fast-pass, and retest methods. The optimized procedure was found to provide improved vehicle preconditioning with a relatively minor decrease in excess emissions identification. Resulting identification rates ranged from 96 to 100% for hydrocarbons (HC), 93-100% for CO, and 93-100% for NOx, depending on cutpoint selection, while false failures caused by lack of vehicle preconditioning were reduced to essentially zero. Significant vehicle throughput improvements were achieved through the development of software algorithms involving modal fast-pass and retest procedures. Modal drive trace variation limits also were developed to improve test accuracy. The combination of the algorithms reduced average IM147 test times by nearly 60%.

  9. FLASH analysis of the MB-2 steady state, operational transient and stability tests

    SciTech Connect

    Coffield, R.D.; Lincoln, F.W.; Johnson, E.G.

    1993-11-01

    This report describes testing performed in the Model Boiler No. 2 (MB-2) facility located at the Westinghouse Engineering Test Facility in Tampa, Florida which provided valuable data for validating steam generator computer code analytical models. MB-2 is scaled to represent a vertical tube Model F steam generator which is used in many commercial PWR plants. A major consideration in the MB-2 test rig design was to make it as prototypical as possible to the Model F commercial PWR steam generator.

  10. Analysis of single ring infiltrometer test by direct numerical modeling

    NASA Astrophysics Data System (ADS)

    Réfloch, Aurore; Oxarango, Laurent; Rossier, Yvan; Gaudet, Jean Paul

    2016-04-01

    The well field of the Lyon metropolitan area provides drinking water to approximately 1,300,000 inhabitants. It is equipped with 12 infiltration basins. These basins have two main goals: sustaining the water table in times of peak demand for water, and preventing a possible contamination from the Rhône river by inverting groundwater flow direction. The water infiltration under the basins is thus crucial for the overall hydrogeologic behavior of the site. In order to characterize this phenomenon, a set of infiltrometer tests were performed to estimate the soil hydraulic properties. The soil is a coarse alluvial deposits. In order to deal with its sparse granulometric curve, a large single ring infiltrometer (1 meter in diameter) was used. A constant hydraulic head (=0.07 m) was imposed during the test. Two kinds of data are recorded: the amount of water infiltrated over time and the extension of the moisture stain around the ring. The main hydraulic properties are estimated using Richard's equation in a 2D axi-symmetric configuration. Simulations are performed using a finite element commercial software package (Comsol Multiphysics 5.1). According to simplified numerical models, an average homogeneous saturated permeability of the alluvial deposits is estimated at 5.0 10-6 m.s-1. However, such a simple model is not able to represent accurately the moisture stain at the soil surface. More complex models introduce anisotropy of permeability in the alluvium layer, with mono or bi-layer domain. In these cases, experimental and modeling results are consistent, both for the amount of water infiltrated over time and the extension of the moisture stain around the ring. The hydraulic anisotropy in the soil could be due to the stratified nature of alluvial deposits and to soil compaction during the construction of infiltration basins. Keywords: Single ring infiltrometer test, artificial aquifer recharge, numerical modeling.

  11. Results of the latest transient well pressure tests at Cerro Prieto

    SciTech Connect

    Abril G, A.; Vargas G, C.

    1981-01-01

    The equipment used in the interference and two-rate flow tests carried out at the Cerro Prieto geothermal field during 1980 are described. The results of two interference tests are presented, one between wells M-110 and M-104, and the other between wells M-7 and Q-757. The data was interpreted using type curve matching analysis. Results of two-rate flow tests carried out in wells M-102 and M-7 are also discussed. A technique for making two-rate flow tests is proposed. This approach, which attempts to avoid the uncertainty of present flow-rate measurements, makes use of devices for direct measurements of separated water and steam. Conclusions based on the above interpretations and recommendations for future tests are presented.

  12. The Mirrortron experiment: A proof of principle test for a method of generating high transient potentials

    SciTech Connect

    Douglass, Scott Roger

    1993-09-01

    The Mirrortron is a concept in which heavy ions are accelerated by a large local transient space potential that is produced in a hot electron plasma. The purpose of this experiment is to begin a proof of principle experiment to investigate the feasibility of producing this space potential and its associated electric field. If a large magnetic field is suddenly generated in a hot electron plasma with a loss-cone distribution, then potentials on the order of the electron temperature are expected. This potential lasts a few tens of nanoseconds. The investigation begins with a theoretical analysis of this phenomenon giving the space potential as a function of the applied magnetic field. The theory is further extended to cases of relativistic electron distributions. This is then followed by design work on a mirror confinement system for hot electrons. In this experiment a 50--100 keV electron temperature plasma is created with electron cyclotron resonance heating using two frequencies of relatively low microwave power. The microwaves are coupled to resonant frequencies of the vacuum chamber. The volume averaged plasma density is measured to be in the 109 cm-3 range. A strap coil and a flat Blumlein transmission line pulse generator were developed to produce a 150 gauss field within 70 ns. The strap coil was placed at the midplane of the mirror field, where the field is 700 gauss. Based on theoretical estimates and computer simulations a 20 kV potential is expected. Measurement of this potential is derived from the modulation of the current of a monoenergetic electron beam after it passes through the high potential region. The variation in the beam energy allows bunching to occur in transit to the detector.

  13. Geological Hypothesis Testing and Investigations of Coupling with Transient Electromagnetics (TEM)

    NASA Astrophysics Data System (ADS)

    Adams, A. C.; Moeller, M. M.; Snyder, E.; Workman, E. J.; Urquhart, S.; Bedrosian, P.; Pellerin, L.

    2014-12-01

    Transient electromagnetic (TEM) data were acquired in Borrego Canyon within the Santo Domingo Basin of the Rio Grande Rift, central New Mexico, during the 2014 Summer of Applied Geophysical Experience (SAGE) field program. TEM surveys were carried out in several regions both to investigate geologic structure and to illustrate the effects of coupling to anthropogenic structures. To determine an optimal survey configuration, 50, 100 and 200 m square transmitter loops were deployed; estimates of depth-of-investigation and logistical considerations determined that 50 m loops were sufficient for production-style measurements. A resistive (100s of ohm-m) layer was identified at a depth of 25-75 m at several locations, and interpreted as dismembered parts of one or more concealed volcanic flows, an interpretation consistent with Tertiary volcanic flows that cap the Santa Anna Mesa immediately to the south. TEM soundings were also made across an inferred fault to investigate whether fault offset is accompanied by lateral changes in electrical resistivity. Soundings within several hundred meters of the inferred fault strand were identical, indicating no resistivity contrast across the fault, and possibly an absence of recent activity. An old windmill and water tank, long-abandoned, offered an excellent laboratory to study the effect of coupling to metallic anthropogenic structures. The character of the measured data strongly suggests the water tank is in electrical contact with the earth (galvanic coupling), and an induced response was persistent to more than 1 second after current turn-off. Coupling effects could be identified at least 150 meters from the tank. Understanding the mechanism behind such coupling and the ability to identify coupled data are critical skills, as one-dimensional modeling of data is affected by such coupling producing artificial conductive layers at depth.

  14. Single Component Sorption-Desorption Test Experimental Design Approach Discussions

    SciTech Connect

    Phil WInston

    2011-09-01

    A task was identified within the fission-product-transport work package to develop a path forward for doing testing to determine behavior of volatile fission products behavior and to engage members of the NGNP community to advise and dissent on the approach. The following document is a summary of the discussions and the specific approaches suggested for components of the testing. Included in the summary isare the minutes of the conference call that was held with INL and external interested parties to elicit comments on the approaches brought forward by the INL participants. The conclusion was that an initial non-radioactive, single component test will be useful to establish the limits of currently available chemical detection methods, and to evaluated source-dispersion uniformity. In parallel, development of a real-time low-concentration monitoring method is believed to be useful in detecting rapid dispersion as well as desorption phenomena. Ultimately, the test cycle is expected to progress to the use of radio-traced species, simply because this method will allow the lowest possible detection limits. The consensus of the conference call was that there is no need for an in-core test because the duct and heat exchanger surfaces that will be the sorption target will be outside the main neutron flux and will not be affected by irradiation. Participants in the discussion and contributors to the INL approach were Jeffrey Berg, Pattrick Calderoni, Gary Groenewold, Paul Humrickhouse, Brad Merrill, and Phil Winston. Participants from outside the INL included David Hanson of General Atomics, Todd Allen, Tyler Gerczak, and Izabela Szlufarska of the University of Wisconsin, Gary Was, of the University of Michigan, Sudarshan Loyalka and Tushar Ghosh of the University of Missouri, and Robert Morris of Oak Ridge National Laboratory.

  15. Single Stage Contactor Testing Of The Next Generation Solvent Blend

    SciTech Connect

    Herman, D. T.; Peters, T. B.; Duignan, M. R.; Williams, M. R.; Poirier, M. R.; Brass, E. A.; Garrison, A. G.; Ketusky, E. T.

    2014-01-06

    The Modular Caustic Side Solvent Extraction (CSSX) Unit (MCU) facility at the Savannah River Site (SRS) is actively pursuing the transition from the current BOBCalixC6 based solvent to the Next Generation Solvent (NGS)-MCU solvent to increase the cesium decontamination factor. To support this integration of NGS into the MCU facility the Savannah River National Laboratory (SRNL) performed testing of a blend of the NGS (MaxCalix based solvent) with the current solvent (BOBCalixC6 based solvent) for the removal of cesium (Cs) from the liquid salt waste stream. This testing utilized a blend of BOBCalixC6 based solvent and the NGS with the new extractant, MaxCalix, as well as a new suppressor, tris(3,7dimethyloctyl) guanidine. Single stage tests were conducted using the full size V-05 and V-10 liquid-to-liquid centrifugal contactors installed at SRNL. These tests were designed to determine the mass transfer and hydraulic characteristics with the NGS solvent blended with the projected heel of the BOBCalixC6 based solvent that will exist in MCU at time of transition. The test program evaluated the amount of organic carryover and the droplet size of the organic carryover phases using several analytical methods. The results indicate that hydraulically, the NGS solvent performed hydraulically similar to the current solvent which was expected. For the organic carryover 93% of the solvent is predicted to be recovered from the stripping operation and 96% from the extraction operation. As for the mass transfer, the NGS solvent significantly improved the cesium DF by at least an order of magnitude when extrapolating the One-stage results to actual Seven-stage extraction operation with a stage efficiency of 95%.

  16. Test of Single-Stage Axial-Flow Fan

    NASA Technical Reports Server (NTRS)

    Bell, E Barton

    1942-01-01

    A single-stage axial fan was built and tested in the shop of the propeller-research tunnel of the NACA. The fan comprised a simple 24-blade rotor having a diameter of 21 inches and a solidity of 0.86 and a set of 37 contravanes having a solidity of 1.33. The rotor was driven by a 25-horsepower motor capable of rotating at a speed of 3600 r.p.m. The fan was tested for volume, pressure, and efficiency over a range of delivery pressures and volumes for a wide range of contravane and blade-angle settings. The test results are presented in chart form in terms of nondimensional units in order that similar fans may be accurately designed with a minimum effort. The maximum efficiency (88 percent) was obtained by the fan at a blade angle of 30 degrees and a contravane angle of 70 degrees. An efficiency of 80 percent was obtained by the fan with the contravanes removed.

  17. Experimental test of Bohr's complementarity principle with single neutral atoms

    NASA Astrophysics Data System (ADS)

    Wang, Zhihui; Tian, Yali; Yang, Chen; Zhang, Pengfei; Li, Gang; Zhang, Tiancai

    2016-12-01

    An experimental test of the quantum complementarity principle based on single neutral atoms trapped in a blue detuned bottle trap was here performed. A Ramsey interferometer was used to assess the wavelike behavior or particlelike behavior with second π /2 rotation on or off. The wavelike behavior or particlelike behavior is characterized by the visibility V of the interference or the predictability P of which-path information, respectively. The measured results fulfill the complementarity relation P2+V2≤1 . Imbalance losses were deliberately introduced to the system and we find the complementarity relation is then formally "violated." All the experimental results can be completely explained theoretically by quantum mechanics without considering the interference between wave and particle behaviors. This observation complements existing information concerning Bohr's complementarity principle based on wave-particle duality of a massive quantum system.

  18. Testing the single degenerate channel for supernova Ia

    NASA Astrophysics Data System (ADS)

    Parsons, Steven

    2014-10-01

    The progenitors of supernova Ia are close binaries containing white dwarfs. Of crucial importance to the evolution of these systems is how much material the white dwarf can stably accrete and hence grow in mass. This occurs during a short-lived intense phase of mass transfer known as the super soft source (SSS) phase. The short duration of this phase and large extinction to soft X-rays means that only a handful are known in our Galaxy. Far more can be learned from the underlying SSS progenitor population of close white dwarf plus FGK type binaries. Unfortunately, these systems are hard to find since the main-sequence stars completely outshine the white dwarfs at optical wavelengths. Because of this, there are currently no known close white dwarf binaries with F, G or early K type companions, making it impossible to determine the contribution of the single degenerate channel towards supernova Ia. Using the GALEX and RAVE surveys we have now identified the first large sample of FGK stars with UV excesses, a fraction of which are these illusive, close systems. Following an intense ground based spectroscopic investigation of these systems, we have identified 5 definite close binaries, with periods of less than a few days. Here we apply for COS spectroscopic observations to measure the mass and temperature of the white dwarfs in order to determine the future evolution of these systems. This will provide a crucial test for the single degenerate channel towards supernova Ia.

  19. A Randomized, Double-Blind, Single-Dose, Placebo-Controlled, Multicenter, Polysomnographic Study of Gabapentin in Transient Insomnia Induced by Sleep Phase Advance

    PubMed Central

    Rosenberg, Russell P.; Hull, Steven G.; Lankford, D. Alan; Mayleben, David W.; Seiden, David J.; Furey, Sandy A.; Jayawardena, Shyamalie; Roth, Thomas

    2014-01-01

    Study Objectives: To evaluate the effects of single doses of gabapentin 250 and 500 mg on polysomnographic (PSG) and participant-reported sleep measures in a 5-h phase advance insomnia model. Methods: Adults reporting occasional disturbed sleep received gabapentin 500 mg (n = 125), 250 mg (n = 125), or placebo (n = 127) 30 min prior to bedtime and were in bed from 17:00 to 01:00, ∼5 h before their habitual bedtime. Sleep was assessed by PSG, post-sleep questionnaire, and the Karolinska Sleep Diary (KSD). Next-day residual effects (Digit Symbol Substitution Test [DSST] and Stanford Sleepiness Scale [SSS]) and tolerability were assessed. Results: Demographics were comparable among groups. Among PSG endpoints, wake after sleep onset (primary endpoint) (135.7 [placebo], 100.7 [250 mg], and 73.2 [500 mg] min) was significantly lower and total sleep time (TST) (311.4, 356.5, and 378.7 min) significantly greater in both gabapentin groups versus placebo. Latency to persistent sleep was not significantly different among groups. Percent slow wave sleep (12.6%, 15.4%, and 17.0%, respectively) was significantly greater and percent stage 1 (15.1%, 11.8%, and 10.8%, respectively) significantly lower relative to placebo. Gabapentin was associated with significantly higher values of KSD Sleep Quality Index and reported TST versus placebo; no other reported outcomes were significant. Neither gabapentin dose produced evidence of next-day residual effects as measured by DSST and SSS. Adverse events were infrequent (< 5%). Conclusion: Participants with occasional disturbed sleep treated with gabapentin showed significantly longer sleep duration and greater depth (versus placebo) in response to a phase advance manipulation known to disrupt sleep maintenance. Citation: Rosenberg RP, Hull SG, Lankford DA, Mayleben DW, Seiden DJ, Furey SA, Jayawardena S, Roth T. A randomized, double-blind, single-dose, placebo-controlled, multicenter, polysomnographic study of gabapentin in transient

  20. Transient behavior of a scaled RCCS test facility under postulated fault and accident scenarios

    SciTech Connect

    Lisowski, Darius D.; Hu, Rui; Bucknor, Matthew D.; Gerardi, Craig D.; Farmer, Mitch T.

    2016-01-01

    Tests were performed on the Natural convection Shutdown heat removal Test Facility (NSTF) to simulate design basis accident and postulated fault scenarios. Residing at Argonne National Laboratory, the NSTF stands nearly 26-m in total height and reflects a ½ scale reactor cavity cooling system (RCCS) for high temperature gas cooled reactors. The following manuscript details three test conditions performed on the experimental test facility. The first simulated the reactor pressure vessel (RPV) boundary condition during depressurized conduction cool down accident with small primary leak, and was repeated during both winter and summer seasons. The second examined a short-circuit break between the inlet and outlet flow paths, and was performed in three incremental stages of nominal flow area break size. The third and final test case studied system behavior with varying amounts of cooling channel blockages, up to and including 50% flow areas. Nominal component temperatures, heat removal performance, and system stability will be presented to characterize the behavior at these conditions.

  1. Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude

    PubMed Central

    Zhang, Wei; Linden, David J.

    2010-01-01

    Most presynaptic terminals in the brain contain G-protein coupled receptors that function to reduce action potential-evoked neurotransmitter release. These neuromodulatory receptors, including those for glutamate, GABA, endocannabinoids and adenosine, exert a substantial portion of their effect by reducing evoked presynaptic Ca2+ transients. Many axons form synapses with multiple postsynaptic neurons, but it is unclear if presynaptic attenuation in these synapses is homogeneous, as suggested by population level Ca2+ imaging. We loaded Ca2+-sensitive dyes into cerebellar parallel fiber axons and imaged action potential-evoked Ca2+ transients in individual presynaptic boutons with application of three different neuromodulators and found that adjacent boutons on the same axon showed striking heterogeneity in their strength of attenuation. Moreover, attenuation was predicted by bouton size or basal Ca2+ response: smaller boutons were more sensitive to adenosine A1 agonist but less sensitive to CB1 agonist while boutons with high basal action potential-evoked Ca2+ transient amplitude were more sensitive to mGluR4 agonist. These results suggest that boutons within brief segment of a single parallel fiber axon can have different sensitivities towards neuromodulators and may have different capacities for both short-term and long-term plasticities. PMID:20007482

  2. Use of derivate for detecting linear impermeable barriers by transient pressure test

    SciTech Connect

    Ascencio, F.; Molinar R.

    1988-01-01

    The goal of this paper is to show a numerical method for evaluate distance at an impermeable barrier, using buildup and drawdown pressure test analysis. This technical needs of derivatives evaluation in transition zone defined between two classics semilog straight lines with slopes “m” and “2m” that are present in these systems. Complementary to this study the authors propose type curves for application in alternatives analysis. An illustrative example is showed using the proposed method.

  3. Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion

    PubMed Central

    Koehler, Sybille; Brähler, Sebastian; Kuczkowski, Alexander; Binz, Julia; Hackl, Matthias J.; Hagmann, Henning; Höhne, Martin; Vogt, Merly C.; Wunderlich, Claudia M.; Wunderlich, F. Thomas; Schweda, Frank; Schermer, Bernhard; Benzing, Thomas; Brinkkoetter, Paul T.

    2016-01-01

    Chronic alterations in calcium (Ca2+) signalling in podocytes have been shown to cause proteinuria and progressive glomerular diseases. However, it is unclear whether short Ca2+ peaks influence glomerular biology and cause podocyte injury. Here we generated a DREADD (Designer Receptor Exclusively Activated by a Designer Drug) knock-in mouse line to manipulate intracellular Ca2+ levels. By mating to a podocyte-specific Cre driver we are able to investigate the impact of Ca2+ peaks on podocyte biology in living animals. Activation of the engineered G-protein coupled receptor with the synthetic compound clozapine-N-oxide (CNO) evoked a short and transient Ca2+ peak in podocytes immediately after CNO administration in vivo. Interestingly, this Ca2+ peak did neither affect glomerular perfusion nor filtration in the animals. Moreover, no obvious alterations in the glomerular morphology could be observed. Taken together, these in vivo findings suggest that chronic alterations and calcium overload rather than an induction of transient Ca2+ peaks contribute to podocyte disease. PMID:27759104

  4. Variable Depth Bragg Peak Method for Single Event Effects Testing

    NASA Technical Reports Server (NTRS)

    Buchner, S.; Kanyogoro, N.; Foster, C.; O'Neill, P.

    2011-01-01

    Traditionally, accelerator SEE testing is accomplished by removing the tops of packages so that the IC chips are accessible to heavy ions. However, ICs in some advanced packages cannot be de-lidded so a different approach is used that involves grinding and/or chemically etching away part of the package and the chip from the back side. The parts are then tested from the back side with ions having sufficient range to reach the sensitive volume. More recently, the entire silicon substrate in an SOI/SRAM was removed, making it possible to use low-energy ions with shorter ranges. Where removal of part of the package is not possible, facilities at Michigan State, NASA Space Radiation Laboratory, GANIL (France) and GSI (Germany) offer high-energy heavy ions with long ranges so that the ions can reach the devices' sensitive volumes without much change in the LET. Unfortunately, a run will typically involve only one ion species having a single energy and LET due to the long time it takes to tune a new energy. The Variable Depth Bragg Peak (VDBP) method is similar to the above method in that it involves the use of high-energy heavy ions that are able to pass through the packaging material and reach the device, obviating the need to remove the package. However, the method provides a broad range of LETs from a single ion by inserting degraders in the beam that modify the ion energy and, therefore, the LET. The crux of the method involves establishing a fiduciary point for degrader thickness, i.e., where the Bragg peak is located precisely at the sensitive volume in the device, for which the measured SEU cross-section and the ion LET are both also maxima and can be calculated using a Monte-Carlo program, TRIM. Once the fiduciary point has been established, calibrated high density polyethylene (HDPE) degraders are inserted into or removed from the beam to vary the ion LET at the device in a known manner. After each change of degrader thickness, the SEU cross-section is measured

  5. Phase V of the single-breath washout test

    NASA Technical Reports Server (NTRS)

    Nichol, G. M.; Michels, D. B.; Guy, H. J. B.

    1982-01-01

    A downward-deflecting phase V is often seen following the terminal rise (phase IV) in single-breath washout tests. To investigate the nature of phase V, experiments using simultaneous washouts of N2 and tracer boluses of Ar were performed on eight normal nonsmoking subjects aged 27-41 who exhibited a phase V. Phase V is found to occur in all subjects at expiratory flow rates between 0.1 and 2.0 l/sec shortly after expiration became flow limited. Volumes of both phases IV and V increase with increasing flow rate. The difference between the exhaled volumes at which flow became limited and phase V appeared is shown to be approximately equal to the anatomic dead space. Results support a model of lung emptying in a gravitational field in which flow limitation occurs first in the lower lung regions and then progresses toward the upper regions, causing phase IV. A decrease in the amount of flow from the upper relative to the lower regions after all regions have become flow limited then causes phase V.

  6. Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate and behave like transient amplifying cells

    SciTech Connect

    Yamada, Yoji; Sakurada, Kazuhiro; Takeda, Yukiji; Gojo, Satoshi; Umezawa, Akihiro . E-mail: umezawa@1985.jukuin.keio.ac.jp

    2007-02-15

    Bone marrow-derived stromal cells can give rise to cardiomyocytes as well as adipocytes, osteocytes, and chondrocytes in vitro. The existence of mesenchymal stem cells has been proposed, but it remains unclear if a single-cell-derived stem cell stochastically commits toward a cardiac lineage. By single-cell marking, we performed a follow-up study of individual cells during the differentiation of 9-15c mesenchymal stromal cells derived from bone marrow cells. Three types of cells, i.e., cardiac myoblasts, cardiac progenitors and multipotent stem cells were differentiated from a single cell, implying that cardiomyocytes are generated stochastically from a single-cell-derived stem cell. We also demonstrated that overexpression of Csx/Nkx2.5 and GATA4, precardiac mesodermal transcription factors, enhanced cardiomyogenic differentiation of 9-15c cells, and the frequency of cardiomyogenic differentiation was increased by co-culturing with fetal cardiomyocytes. Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 behaved like cardiac transient amplifying cells, and still retained their plasticity in vivo.

  7. 78 FR 44189 - Petition for Modification of Single Car Air Brake Test Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... Federal Railroad Administration Petition for Modification of Single Car Air Brake Test Procedures In... the Federal Railroad Administration (FRA) per 49 CFR 232.307 to modify the single car air brake test procedures located in AAR Standard S-486, Code of Air Brake System Tests for Freight Equipment-- Single...

  8. COBRA-WC: a version of COBRA for single-phase multiassembly thermal hydraulic transient analysis. [LMFBR

    SciTech Connect

    George, T.L.; Basehore, K.L.; Wheeler, C.L.; Prather, W.A.; Masterson, R.E.

    1980-07-01

    The objective of this report is to provide the user of the COBRA-WC (Whole Core) code a basic understanding of the code operation and capabilities. Included in this manual are the equations solved and the assumptions made in their derivations, a general description of the code capabilities, an explanation of the numerical algorithms used to solve the equations, and input instructions for using the code. Also, the auxiliary programs GEOM and SPECSET are described and input instructions for each are given. Input for COBRA-WC sample problems and the corresponding output are given in the appendices. The COBRA-WC code has been developed from the COBRA-IV-I code to analyze liquid Metal Fast Breeder Reactor (LMFBR) assembly transients. It was specifically developed to analyze a core flow coastdown to natural circulation cooling.

  9. [Acute stent thrombosis and reverse transient left ventricular dilatation after performing a single-photon emission computed tomography myocardial perfusion].

    PubMed

    Miranda, B; Pizzi, M N; Aguadé-Bruix, S; Domingo, E; Candell-Riera, J

    2015-01-01

    A 63-year-old male patient with a history of stent implantation in the left anterior descending three months before. Due to the presentation of vegetative symptoms, he was referred for gated-SPECT myocardial perfusion. During acquisition of the resting images he presented chest pain and ST segment elevation, so that urgent cardiac catheterization was performed, showing stent thrombosis. Rest perfusion imaging showed a defect in anterior and apical perfusion, more severe and extensive than in the stress images, with striking left ventricular dilatation and a fall in the ejection fraction related to the acute ischemia phenomenon. Intense exercise is associated with a transient activation of the coagulation system and hemodynamic changes that might induce thrombosis, especially in recently implanted coronary stents that probably still have not become completely endothelialized.

  10. Acoustic Data Processing and Transient Signal Analysis for the Hybrid Wing Body 14- by 22-Foot Subsonic Wind Tunnel Test

    NASA Technical Reports Server (NTRS)

    Bahr, Christopher J.; Brooks, Thomas F.; Humphreys, William M.; Spalt, Taylor B.; Stead, Daniel J.

    2014-01-01

    An advanced vehicle concept, the HWB N2A-EXTE aircraft design, was tested in NASA Langley's 14- by 22-Foot Subsonic Wind Tunnel to study its acoustic characteristics for var- ious propulsion system installation and airframe con gurations. A signi cant upgrade to existing data processing systems was implemented, with a focus on portability and a re- duction in turnaround time. These requirements were met by updating codes originally written for a cluster environment and transferring them to a local workstation while en- abling GPU computing. Post-test, additional processing of the time series was required to remove transient hydrodynamic gusts from some of the microphone time series. A novel automated procedure was developed to analyze and reject contaminated blocks of data, under the assumption that the desired acoustic signal of interest was a band-limited sta- tionary random process, and of lower variance than the hydrodynamic contamination. The procedure is shown to successfully identify and remove contaminated blocks of data and retain the desired acoustic signal. Additional corrections to the data, mainly background subtraction, shear layer refraction calculations, atmospheric attenuation and microphone directivity corrections, were all necessary for initial analysis and noise assessments. These were implemented for the post-processing of spectral data, and are shown to behave as expected.

  11. Radiation-Induced Transient Effects in Near Infrared Focal Plane Arrays

    NASA Technical Reports Server (NTRS)

    Reed, Robert A.; Pickel, J.; Marshall, P.; Waczynski, A.; McMurray, R.; Gee, G.; Polidan, E.; Johnson, S.; McKeivey, M.; Ennico, K.; Johnson, R.

    2004-01-01

    This viewgraph presentation describes a test simulate the transient effects of cosmic ray impacts on near infrared focal plane arrays. The objectives of the test are to: 1) Characterize proton single events as function of energy and angle of incidence; 2) Measure charge spread (crosstalk) to adjacent pixels; 3) Assess transient recovery time.

  12. Time-frequency analyses of transient-evoked stimulus-frequency and distortion-product otoacoustic emissions: Testing cochlear model predictions

    NASA Astrophysics Data System (ADS)

    Konrad-Martin, Dawn; Keefe, Douglas H.

    2003-10-01

    Time-frequency representations (TFRs) of otoacoustic emissions (OAEs) provide information simultaneously in time and frequency that may be obscured in waveform or spectral analyses. TFRs were applied to transient-evoked stimulus-frequency (SF) and distortion-product (DP) OAEs to test cochlear model predictions. SFOAEs and DPOAEs were elicited in 18 normal-hearing subjects using gated tones and tone pips. Synchronous spontaneous (SS) OAEs were measured to assess their contributions to SFOAEs and DPOAEs. A common form of TFR of measured OAEs was a collection of frequency-specific components often aligned with SSOAE sites, with each component characterized by one or more brief segments or a single long-duration segment. The spectral envelope of evoked OAEs differed from that of the evoking stimulus. Strong emission regions or cochlear ``hot spots'' were detected, and sometimes accounted for OAE energy observed outside the stimulus bandwidth. Contributions of hot spots and multiple internal reflections to the OAE, and differences between measured and predicted OAE spectra, increased as stimulus level decreased, consistent with level-dependent changes in the estimated cochlear reflectance. Suppression and frequency-pulling effects between components were observed. A recursive formulation was described for the linear coherent reflection emission theory [Zweig and Shera, J. Acoust. Soc. Am. 98, 2018-2047 (1995)] that is well suited for time-domain calculations.

  13. Initial test results with single cylinder rhombic drive Stirling engine

    NASA Technical Reports Server (NTRS)

    Cairelli, J. E.

    1978-01-01

    A brief description is given of the GPU 3-2 hardware, the test methods used, and the result of these tests. Comparison is made to unpublished data from similar hydrogen tests performed by the U.S. Army.

  14. A preliminary comparison of the transient effects of single versus multiple q-switched doubled-neodymium laser pulses

    NASA Astrophysics Data System (ADS)

    Previc, Fred H.

    1987-09-01

    A comparison between the effects of single and multiple laser pulse-trains of equivalent energy was performed. Visual evoked potentials (VEPS) recorded bipolarly from the visual cortex of two rhesus monkeys in response to a counterphasing grating were used to assess the magnitude of the visual loss following four types of exposures: single and multiple pulses with total energies equal to 50 and 500 percent of the maximum permissible exposure (MPE) standard for humans. The results showed that the effects of a series of laser flashes presented within 200 ms are similar to those of a single laser flash whose energy is equivalent to the cumulative energy of the multiple-pulse exposure.

  15. Info-gap robustness for the correlation of tests and simulations of a non-linear transient

    NASA Astrophysics Data System (ADS)

    Hemez, François M.; Ben-Haim, Yakov

    2004-11-01

    An alternative to the theory of probability is applied to the problem of assessing the robustness, to uncertainty in model parameters, of the correlation between measurements and computer simulations. The analysis is based on the theory of information-gap uncertainty, which models the clustering of uncertain events in families of nested sets instead of assuming a probability structure. The system investigated is the propagation of a transient impact through a layer of hyper-elastic material. The two sources of non-linearity are (1) the softening of the constitutive law representing the hyper-elastic material and (2) the contact dynamics at the interface between metallic and crushable materials. The robustness of the correlation between test and simulation, to sources of parameter variability, is first studied to identify the parameters of the model that significantly influence the agreement between measurements and predictions. Model updating under non-probabilistic uncertainty is then illustrated, based on two complementary immunity functions: the robustness to uncertainty and the opportunity from uncertainty. Finally an info-gap model is embedded within a probability density function to represent uncertainty in the knowledge of the model's parameters and their correlation structure. Although computationally expensive, it is demonstrated that info-gap reasoning can greatly enhance our understanding of a moderately complex system when the theory of probability cannot be applied due to insufficient information.

  16. Summary of air permeability data from single-hole injection tests in unsaturated fractured tuffs at the Apache Leap Research Site: Results of steady-state test interpretation

    SciTech Connect

    Guzman, A.G.; Geddis, A.M.; Henrich, M.J.; Lohrstorfer, C.F.; Neuman, S.P.

    1996-03-01

    This document summarizes air permeability estimates obtained from single hole pneumatic injection tests in unsaturated fractured tuffs at the Covered Borehole Site (CBS) within the larger apache Leap Research Site (ALRS). Only permeability estimates obtained from a steady state interpretation of relatively stable pressure and flow rate data are included. Tests were conducted in five boreholes inclined at 45{degree} to the horizontal, and one vertical borehole. Over 180 borehole segments were tested by setting the packers 1 m apart. Additional tests were conducted in segments of lengths 0.5, 2.0, and 3.0 m in one borehole, and 2.0 m in another borehole, bringing the total number of tests to over 270. Tests were conducted by maintaining a constant injection rate until air pressure became relatively stable and remained so for some time. The injection rate was then incremented by a constant value and the procedure repeated. The air injection rate, pressure, temperature, and relative humidity were recorded. For each relatively stable period of injection rate and pressure, air permeability was estimated by treating the rock around each test interval as a uniform, isotropic porous medium within which air flows as a single phase under steady state, in a pressure field exhibiting prolate spheroidal symmetry. For each permeability estimate the authors list the corresponding injection rate, pressure, temperature and relative humidity. They also present selected graphs which show how the latter quantities vary with time; logarithmic plots of pressure versus time which demonstrate the importance of borehole storage effects during the early transient portion of each incremental test period; and semilogarithmic plots of pressure versus recovery time at the end of each test sequence.

  17. 49 CFR 232.307 - Modification of the single car air brake test procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Modification of the single car air brake test... Requirements § 232.307 Modification of the single car air brake test procedures. (a) Request. The AAR or other authorized representative of the railroad industry may seek modification of the single car air brake...

  18. 49 CFR 232.307 - Modification of the single car air brake test procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Modification of the single car air brake test... Requirements § 232.307 Modification of the single car air brake test procedures. (a) Request. The AAR or other authorized representative of the railroad industry may seek modification of the single car air brake...

  19. 49 CFR 232.307 - Modification of the single car air brake test procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Modification of the single car air brake test... Requirements § 232.307 Modification of the single car air brake test procedures. (a) Request. The AAR or other authorized representative of the railroad industry may seek modification of the single car air brake...

  20. Temperature dependent transient surface photovoltage spectroscopy of a Cu1.95Zn1.1Sn0.96Se4 kesterite single phase powder

    NASA Astrophysics Data System (ADS)

    Dittrich, Th.; Valle Rios, L. E.; Kapil, S.; Gurieva, G.; Rujisamphan, N.; Schorr, S.

    2017-01-01

    An off-stoichiometric but single phase Cu1.95Zn1.1Sn0.96Se4 kesterite powder was investigated by temperature dependent transient surface photovoltage (SPV) spectroscopy. SPV signals excited at different wavelengths were transformed into SPV spectra that depended on the response time of measurement. Shallow electronic states and states with transition energies at 0.83 eV or 0.78… 0.9 eV were distinguished. The temperature dependence of the band gap of Cu1.95Zn1.1Sn0.96Se4 was obtained. Results were discussed on the basis of defects in Cu-poor and Zn-rich kesterite.

  1. Results of the ETV-1 breadboard tests under steady-state and transient conditions. [conducted in the NASA-LeRC Road Load Simulator

    NASA Technical Reports Server (NTRS)

    Sargent, N. B.; Dustin, M. O.

    1981-01-01

    Steady state tests were run to characterize the system and component efficiencies over the complete speed-torque capabilities of the propulsion system in both motoring and regenerative modes of operation. The steady state data were obtained using a battery simulator to separate the effects on efficiency caused by changing battery state-of-charge and component temperature. Transient tests were performed to determine the energy profiles of the propulsion system operating over the SAE J227a driving schedules.

  2. Single-molecule spectroscopy and femtosecond transient absorption studies on the excitation energy transfer process in ApcE(1-240) dimers.

    PubMed

    Long, Saran; Zhou, Meng; Tang, Kun; Zeng, Xiao-Li; Niu, Yingli; Guo, Qianjin; Zhao, Kai-Hong; Xia, Andong

    2015-05-28

    ApcE(1-240) dimers with one intrinsic phycocyanobilin (PCB) chromophore in each monomer that is truncated from the core-membrane linker (ApcE) of phycobilisomes (PBS) in Nostoc sp. PCC 7120 show a sharp and significantly red-shifted absorption. Two explanations either conformation-dependent Förster resonance energy transfer (FRET) or the strong exciton coupling limit have been proposed for red-shifted absorption. This is a classic example of the special pair in the photosynthetic light harvesting proteins, but the mechanism of this interaction is still a matter of intense debate. We report the studies using single-molecule and transient absorption spectra on the interaction in the special pair of ApcE dimers. Our results demonstrate the presence of conformation-dependent FRET between the two PCB chromophores in ApcE dimers. The broad distributions of fluorescence intensities, lifetimes and polarization difference from single-molecule measurements reveal the heterogeneity of local protein-pigment environments in ApcE dimers, where the same molecular structures but different protein environments are the main reason for the two PCB chromophores with different spectral properties. The excitation energy transfer rate between the donor and the acceptor about (110 ps)(-1) is determined from transient absorption measurements. The red-shifted absorption in ApcE dimers could result from more extending conformation, which shows another type of absorption redshift that does not depend on strong exciton coupling. The results here stress the importance of conformation-controlled spectral properties of the chemically identical chromophores, which could be a general feature to control energy/electron transfer, widely existing in the light harvesting complexes.

  3. Mechanical testing of large thallium doped sodium iodide single crystals

    NASA Technical Reports Server (NTRS)

    Lee, H. M.

    1985-01-01

    The findings of mechanical tests performed on five thallium-doped sodium iodide NaI(Tl) crystals are presented. These crystals are all in the shape of circular flat plates, 20.0 in. in diameter an d0.5 in. thick. The test setup, testing procedure, and the test data are presented. Large crystals exhibit a high degree of material plasticity, as well as a much higher strength than previously anticipated, on the order of 500 psi. Also revealed from the testing is the fact that crystal with a large number of grain boundaries developed less plasticity, and therefore less permanent deformation, than those with fewer grain boundaries.

  4. Techniques of Microprocessor Testing and SEU (Single Event Upset)-Rate Prediction.

    DTIC Science & Technology

    1986-08-15

    be tested in a simple computer configuration, e.g., single board computer . The proces- sor "self-tests"~ and the result of the self-test can be...register or in the program counter. Following such an event, the single board computer would sometimes lose track of itself, and a catastrophic

  5. Test report for single event effects of the 80386DX microprocessor

    NASA Technical Reports Server (NTRS)

    Watson, R. Kevin; Schwartz, Harvey R.; Nichols, Donald K.

    1993-01-01

    The Jet Propulsion Laboratory Section 514 Single Event Effects (SEE) Testing and Analysis Group has performed a series of SEE tests of certain strategic registers of Intel's 80386DX CHMOS 4 microprocessor. Following a summary of the test techniques and hardware used to gather the data, we present the SEE heavy ion and proton test results. We also describe the registers tested, along with a system impact analysis should these registers experience a single event upset.

  6. Neutronics, steady-state, and transient analyses for the Poland MARIA reactor for irradiation testing of LEU lead test fuel assemblies from CERCA : ANL independent verification results.

    SciTech Connect

    Garner, P. L.; Hanan, N. A.

    2011-06-07

    The MARIA reactor at the Institute of Atomic Energy (IAE) in Swierk (30 km SE of Warsaw) in the Republic of Poland is considering conversion from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel assemblies (FA). The FA design in MARIA is rather unique; a suitable LEU FA has never been designed or tested. IAE has contracted with CERCA (the fuel supply portion of AREVA in France) to supply 2 lead test assemblies (LTA). The LTAs will be irradiated in MARIA to burnup level of at least 40% for both LTAs and to 60% for one LTA. IAE may decide to purchase additional LEU FAs for a full core conversion after the test irradiation. The Reactor Safety Committee within IAE and the National Atomic Energy Agency in Poland (PAA) must approve the LTA irradiation process. The approval will be based, in part, on IAE submitting revisions to portions of the Safety Analysis Report (SAR) which are affected by the insertion of the LTAs. (A similar process will be required for the full core conversion to LEU fuel.) The analysis required was established during working meetings between Argonne National Laboratory (ANL) and IAE staff during August 2006, subsequent email correspondence, and subsequent staff visits. The analysis needs to consider the current high-enriched uranium (HEU) core and 4 core configurations containing 1 and 2 LEU LTAs in various core positions. Calculations have been performed at ANL in support of the LTA irradiation. These calculations are summarized in this report and include criticality, burn-up, neutronics parameters, steady-state thermal hydraulics, and postulated transients. These calculations have been performed at the request of the IAE staff, who are performing similar calculations to be used in their SAR amendment submittal to the PAA. The ANL analysis has been performed independently from that being performed by IAE and should only be used as one step in the verification process.

  7. Thermal modeling of the NASA-Ames Research Center Cryogenic Optical Test Facility and a single-arch, fused-natural-quartz mirror

    NASA Technical Reports Server (NTRS)

    Ng, Y. S.; Augason, Gordon C.; Young, Jeffrey A.; Howard, Steven D.; Melugin, Ramsey K.

    1990-01-01

    A thermal model of the dewar and optical system of the Cryogenic Optical Test Facility at NASA-Ames Research Center was developed using the computer codes SINDA and MONTE CARLO. The model was based on the geometry, boundary conditions, and physical properties of the test facility and was developed to investigate heat transfer mechanisms and temperatures in the facility and in test mirrors during cryogenic optical tests. A single-arch, fused-natural-quartz mirror was the first mirror whose thermal loads and temperature distributions were modeled. From the temperature distribution, the thermal gradients in the mirror were obtained. The model predicted that a small gradient should exist for the single arch mirror. This was later verified by the measurement of mirror temperatures. The temperatures, predicted by the model at various locations within the dewar, were in relatively good agreement with the measured temperatures. The model is applicable to both steady-state and transient cooldown operations.

  8. Development and Testing of Recombinant Single Domain Antibodies

    DTIC Science & Technology

    2010-12-31

    critical insights to the basis of the sdAb-target interaction and sdAb properties. (a) Papers published in peer-reviewed journals (N/A for none) Structures...Goldman E.R. 2010 Binding Kinetics of anti-Ricin Single Domain Antibodies and Improved Detection Using a B-chain Specific Binder. Analytical...Library. Anal. Chem. 78:8245-55 List of papers submitted or published that acknowledge ARO support during this reporting period. List the papers

  9. Shape evolution of a single liquid-crystal droplet immersed in an isotropic matrix under transient and steady flow.

    PubMed

    Wu, Youjun; Yu, Wei; Zhou, Chixing; Xu, Yuanze

    2007-04-01

    The morphology evolution of immiscible polymer-liquid crystal systems is quite different from flexible polymer-polymer mixtures due to the anisotropic properties of liquid crystals. The deformation and retraction of a single low molar mass liquid crystal 4'-pentyl-4-biphenylcarbonitrile (5CB) droplet and 4'-octyl-4-biphenylcarbonitrile (8CB) dispersed in polydimethyl-siloxane under two-dimensional linear flow was investigated by a computer-controlled four-roll mill, which is equipped with an optical microscope and a digital camera. The deformation parameter and orientation angle during deformation versus capillary number was obtained and compared with calculations using the Maffettone-Minale (MM) model and the Yu-Zhou liquid-crystal (YZ-LC) model. The MM model can describe the behavior of a Newtonian droplet in another Newtonian matrix whereas the YZ-LC model can describe the behavior of a LC droplet in a Newtonian matrix. The results showed that the deformation and rotation of a LC droplet is more difficult than viscoelastic droplets, possibly because of the resistance of the nematic elastic energy induced by the nematic mesogens deformation and orientation under flow field. Furthermore, the different behavior between flow-aligning 5CB and flow-tumbling 8CB droplets and the influence of droplet size of LC on deformation and retraction were discussed by experiment and calculation; the results reveal that the different size LC droplets show different evolution curves.

  10. Testing single point incremental forming molds for thermoforming operations

    NASA Astrophysics Data System (ADS)

    Afonso, Daniel; de Sousa, Ricardo Alves; Torcato, Ricardo

    2016-10-01

    Low pressure polymer processing processes as thermoforming or rotational molding use much simpler molds then high pressure processes like injection. However, despite the low forces involved with the process, molds manufacturing for this operations is still a very material, energy and time consuming operation. The goal of the research is to develop and validate a method for manufacturing plastically formed sheets metal molds by single point incremental forming (SPIF) operation for thermoforming operation. Stewart platform based SPIF machines allow the forming of thick metal sheets, granting the required structural stiffness for the mold surface, and keeping the short lead time manufacture and low thermal inertia.

  11. Predictions of Transient Flame Lift-Off Length With Comparison to Single-Cylinder Optical Engine Experiments

    SciTech Connect

    Senecal, P. K.; Pomraning, E.; Anders, J. W.; Weber, M. R.; Gehrke, C. R.; Polonowski, C. J.; Mueller, C. J.

    2014-05-28

    A state-of-the-art, grid-convergent simulation methodology was applied to three-dimensional calculations of a single-cylinder optical engine. A mesh resolution study on a sector-based version of the engine geometry further verified the RANS-based cell size recommendations previously presented by Senecal et al. (“Grid Convergent Spray Models for Internal Combustion Engine CFD Simulations,” ASME Paper No. ICEF2012-92043). Convergence of cylinder pressure, flame lift-off length, and emissions was achieved for an adaptive mesh refinement cell size of 0.35 mm. Furthermore, full geometry simulations, using mesh settings derived from the grid convergence study, resulted in excellent agreement with measurements of cylinder pressure, heat release rate, and NOx emissions. On the other hand, the full geometry simulations indicated that the flame lift-off length is not converged at 0.35 mm for jets not aligned with the computational mesh. Further simulations suggested that the flame lift-off lengths for both the nonaligned and aligned jets appear to be converged at 0.175 mm. With this increased mesh resolution, both the trends and magnitudes in flame lift-off length were well predicted with the current simulation methodology. Good agreement between the overall predicted flame behavior and the available chemiluminescence measurements was also achieved. Our present study indicates that cell size requirements for accurate prediction of full geometry flame lift-off lengths may be stricter than those for global combustion behavior. This may be important when accurate soot predictions are required.

  12. Bilateral force transients in the upper limbs evoked by single-pulse microstimulation in the pontomedullary reticular formation

    PubMed Central

    Hirschauer, Thomas J.

    2015-01-01

    Neurons in the pontomedullary reticular formation (PMRF) give rise to the reticulospinal tract. The motor output of the PMRF was investigated using stimulus-triggered averaging of electromyography (EMG) and force recordings in two monkeys (M. fascicularis). EMG was recorded from 12 pairs of upper limb muscles, and forces were detected using two isometric force-sensitive handles. Of 150 stimulation sites, 105 (70.0%) produced significant force responses, and 139 (92.5%) produced significant EMG responses. Based on the average flexor EMG onset latency of 8.3 ms and average force onset latency of 15.9 ms poststimulation, an electromechanical delay of ∼7.6 ms was calculated. The magnitude of force responses (∼10 mN) was correlated with the average change in EMG activity (P < 0.001). A multivariate linear regression analysis was used to estimate the contribution of each muscle to force generation, with flexors and extensors exhibiting antagonistic effects. A predominant force output pattern of ipsilateral flexion and contralateral extension was observed in response to PMRF stimulation, with 65.3% of significant ipsilateral force responses directed medially and posteriorly (P < 0.001) and 78.6% of contralateral responses directed laterally and anteriorly (P < 0.001). This novel approach permits direct measurement of force outputs evoked by central nervous system microstimulation. Despite the small magnitude of poststimulus EMG effects, low-intensity single-pulse microstimulation of the PMRF evoked detectable forces. The forces, showing the combined effect of all muscle activity in the arms, are consistent with reciprocal pattern of force outputs from the PMRF detectable with stimulus-triggered averaging of EMG. PMID:25652926

  13. Predictions of Transient Flame Lift-Off Length With Comparison to Single-Cylinder Optical Engine Experiments

    DOE PAGES

    Senecal, P. K.; Pomraning, E.; Anders, J. W.; ...

    2014-05-28

    A state-of-the-art, grid-convergent simulation methodology was applied to three-dimensional calculations of a single-cylinder optical engine. A mesh resolution study on a sector-based version of the engine geometry further verified the RANS-based cell size recommendations previously presented by Senecal et al. (“Grid Convergent Spray Models for Internal Combustion Engine CFD Simulations,” ASME Paper No. ICEF2012-92043). Convergence of cylinder pressure, flame lift-off length, and emissions was achieved for an adaptive mesh refinement cell size of 0.35 mm. Furthermore, full geometry simulations, using mesh settings derived from the grid convergence study, resulted in excellent agreement with measurements of cylinder pressure, heat release rate,more » and NOx emissions. On the other hand, the full geometry simulations indicated that the flame lift-off length is not converged at 0.35 mm for jets not aligned with the computational mesh. Further simulations suggested that the flame lift-off lengths for both the nonaligned and aligned jets appear to be converged at 0.175 mm. With this increased mesh resolution, both the trends and magnitudes in flame lift-off length were well predicted with the current simulation methodology. Good agreement between the overall predicted flame behavior and the available chemiluminescence measurements was also achieved. Our present study indicates that cell size requirements for accurate prediction of full geometry flame lift-off lengths may be stricter than those for global combustion behavior. This may be important when accurate soot predictions are required.« less

  14. Qualification test procedures and results for Honeywell solar collector subsystem, single-family residence

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The test procedures and results in qualifying the Honeywell single family residence solar collector subsystem are presented. Testing was done in the following areas: pressure, service loads, hail, solar degradation, pollutants, thermal degradation, and outgassing.

  15. Groin Exploration for the Nonpalpable Testes: A Single Center Experience

    PubMed Central

    Sowande, Oludayo A; Talabi, Ademola O; Etonyeaku, Amarachukwu C; Adejuyigbe, Olusanya

    2015-01-01

    Background: Management of non-palpable testes in Nigeria can be difficult due to late presentation and poor resources. Surgical exploration is often required for diagnosis and treatment. Aim: This study reviews the management outcome of clinically non-palpable testeis in a tertiary center in Nigeria. Materials and Methods: Ten years retrospective review of all clinically non-palpable testes in children aged 2–15years managed at the Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife Nigeria. Results: Thirty two children with 44 testicular units were managed. The right side was involved in 12 (37.5%); left in 8 (25.0%) and bilateral in 12 (37.5%) patients. Pre-operative ultrasound was done in 12 patients with localization in just 4 patients (33.3% success rate). At groin exploration, 34 (77.32%) testicular units were located in the inguinal canal. Eight patients with 10 The remaining 10 (22.7%) testicular units required additional mini-laparotomy for which six (13.6%) and 4 (9.1%) testicular units respectively were either in the retroperitoneum or not found. Of the testes in the groin, twenty two (64.7%) testicular units were normal while 12 (35.3%) were atrophic. Four of the retroperitoneal testes were normal while 2 were atrophic. Eight (22.5%) testicular units among the inguinal group had multi-staged orchidopexy; while 2 each of the retroperitoneal group had orchidectomy, one stage orchidopexy, two staged Fowler Stephens (F-S) procedure or lost to follow up after first stage of F-S procedure. Mean follow up period was 2 months. 2 testicular units each had retracted or vanished respectively during follow up. Conclusion: Groin exploration still offers a viable approach Surgical exploration is still useful in to the management of non-palpable testes in low resource environment despite the lack of laparoscopy. PMID:25838769

  16. COMMIX-1AR/P: A three-dimensional transient single-phase computer program for thermal hydraulic analysis of single and multicomponent systems. Volume 2, User`s guide

    SciTech Connect

    Garner, P.L.; Blomquist, R.N.; Gelbard, E.M.

    1992-09-01

    The COMMIX-1AR/P computer program is designed for analyzing the steady-state and transient aspects of single-phase fluid flow and heat transfer in three spatial dimensions. This version is an extension of the modeling in COMMIX-1A to include multiple fluids in physically separate regions of the computational domain, modeling descriptions for pumps, radiation heat transfer between surfaces of the solids which are embedded in or surround the fluid, a k-{var_epsilon} model for fluid turbulence, and improved numerical techniques. The porous-medium formulation in COMMIX allows the program to be applied to a wide range of problems involving both simple and complex geometrical arrangements. The input preparation and execution procedures are presented for the COMMIX-1AR/P program and several postprocessor programs which produce graphical displays of the calculated results.

  17. COMMIX-1AR/P: A three-dimensional transient single-phase computer program for thermal hydraulic analysis of single and multicomponent systems. Volume 3, Programmer`s guide

    SciTech Connect

    Garner, P.L.; Blomquist, R.N.; Gelbard, E.M.

    1992-09-01

    The COMMIX-LAR/P computer program is designed for analyzing the steady-state and transient aspects of single-phase fluid flow and heat transfer in three spatial dimensions. This version is an extension of the modeling in COMMIX-lA to include multiple fluids in physically separate regions of the computational domain, modeling descriptions for pumps, radiation heat transfer between surfaces of the solids which are embedded in or surround the fluid, a keg model for fluid turbulence, and improved numerical techniques. The porous-medium formulation in COMMIX allows the program to be applied to a wide range of problems involving both simple and complex geometrical arrangements. The internal aspects of the COMMIX-LAR/P program are presented, covering descriptions of subprograms, variables, and files.

  18. Noninvasive measurement of liver fibrosis by transient elastography and influencing factors in patients with chronic hepatitis B-A single center retrospective study of 466 patients.

    PubMed

    Ding, Hongfang; Wu, Ting; Ma, Ke; Wang, Xiaojing; Wu, Zeguang; Guo, Wei; Qi, Junying; Ning, Qin

    2012-02-01

    The noninvasive measurement of liver stiffness (LS) was evaluated by transient elastography (FibroScan) and the possible influencing factors from the patients' clinical situations including age, gender, liver inflammation represented by alanine transaminase (ALT) and total billirubin (TBIL) level, HBV replication (HBV DNA loads), portal vein pressure (portal vessel diameter, PVD), splenic thickness (SPT) and body mass index (BMI) were analyzed in patients with chronic hepatitis B (CHB). A total of 466 patients including 31 patients with acute-on-chronic liver failure (ACLF), and 435 patients with chronic hepatitis B (CHB) among which 82 patients were diagnosed with liver cirrhosis (LC) by clinical manifestations and liver B-type ultrasonic inspection were enrolled at Tongji Hospital from April to December 2009. LS was measured by a FibroScan device (EchoSens, France). Simultaneously, ALT and TBIL levels, HBV DNA loads, PVD, SPT and BMI in all patients were also tested. Forty-one healthy volunteers served as controls. The values of LS were correlated positively with ages of CHB patients and significantly higher in males than in females. In patients with BMI>28 kg/m(2) (obesity) and abnormal levels of ALT and TBIL, LS values were significantly increased as compared with those having normal levels of ALT and TBIL. The patients with ACLF had the highest LS value. Furthermore, LS values in the patients with LC were significantly higher than those in patients without LC. It is concluded that noninvasive measurement of liver fibrosis by FibroScan provides an alternative method to evaluate liver fibrosis of patients with CHB. In order to properly illustrate the stiffness value taken by transient elastography, patients' gender should be taken into consideration and it is also suggested to avoid possible influencing factors including liver inflammation (high levels of ALT and TBIL) and obesity (high BMI).

  19. Test procedures and instructions for single shell tank saltcake cesium removal with crystalline silicotitanate

    SciTech Connect

    Duncan, J.B.

    1997-01-07

    This document provides specific test procedures and instructions to implement the test plan for the preparation and conduct of a cesium removal test, using Hanford Single Shell Tank Saltcake from tanks 24 t -BY- I 10, 24 1 -U- 108, 24 1 -U- 109, 24 1 -A- I 0 1, and 24 t - S-102, in a bench-scale column. The cesium sorbent to be tested is crystalline siticotitanate. The test plan for which this provides instructions is WHC-SD-RE-TP-024, Hanford Single Shell Tank Saltcake Cesium Removal Test Plan.

  20. Calcium Transients in Dendrites of Neocortical Neurons Evoked by Single Subthreshold Excitatory Postsynaptic Potentials via Low-Voltage-Activated Calcium Channels

    NASA Astrophysics Data System (ADS)

    Markram, Henry; Sakmann, Bert

    1994-05-01

    Simultaneous recordings of membrane voltage and concentration of intracellular Ca2+ ([Ca2+]_i) were made in apical dendrites of layer 5 pyramidal cells of rat neocortex after filling dendrites with the fluorescent Ca2+ indicator Calcium Green-1. Subthreshold excitatory postsynaptic potentials (EPSPs), mediated by the activation of glutamate receptor channels, caused a brief increase in dendritic [Ca2+]_i. This rise in dendritic [Ca2+]_i was mediated by the opening of low-voltage-activated Ca2+ channels in the dendritic membrane. The results provide direct evidence that dendrites do not function as passive cables even at low-frequency synaptic activity; rather, a single subthreshold EPSP changes the dendritic membrane conductance by opening Ca2+ channels and generating a [Ca2+]_i transient that may propagate towards the soma. The activation of these Ca2+ channels at a low-voltage threshold is likely to influence the way in which dendritic EPSPs contribute to the electrical activity of the neuron.

  1. Dynamics of Charged Excitons and Biexcitons in CsPbBr3 Perovskite Nanocrystals Revealed by Femtosecond Transient-Absorption and Single-Dot Luminescence Spectroscopy.

    PubMed

    Yarita, Naoki; Tahara, Hirokazu; Ihara, Toshiyuki; Kawawaki, Tokuhisa; Sato, Ryota; Saruyama, Masaki; Teranishi, Toshiharu; Kanemitsu, Yoshihiko

    2017-03-16

    Metal-halide perovskite nanocrystals (NCs) are promising photonic materials for use in solar cells, light-emitting diodes, and lasers. The optoelectronic properties of these devices are determined by the excitons and exciton complexes confined in their NCs. In this study, we determined the relaxation dynamics of charged excitons and biexcitons in CsPbBr3 NCs using femtosecond transient-absorption (TA), time-resolved photoluminescence (PL), and single-dot second-order photon correlation spectroscopy. Decay times of ∼40 and ∼200 ps were obtained from the TA and PL decay curves for biexcitons and charged excitons, respectively, in NCs with an average edge length of 7.7 nm. The existence of charged excitons even under weak photoexcitation was confirmed by the second-order photon correlation measurements. We found that charged excitons play a dominant role in luminescence processes of CsPbBr3 NCs. Combining different spectroscopic techniques enabled us to clarify the dynamical behaviors of excitons, charged excitons, and biexcitons.

  2. Defects in virgin and N+ -implanted ZnO single crystals studied by positron annihilation, Hall effect, and deep-level transient spectroscopy

    NASA Astrophysics Data System (ADS)

    Brauer, G.; Anwand, W.; Skorupa, W.; Kuriplach, J.; Melikhova, O.; Moisson, C.; von Wenckstern, H.; Schmidt, H.; Lorenz, M.; Grundmann, M.

    2006-07-01

    High-quality single crystals of ZnO in the as-grown and N+ ion-implanted states have been investigated using a combination of three experimental techniques—namely, positron lifetime/slow positron implantation spectroscopy accompanied by theoretical calculations of the positron lifetime for selected defects, temperature-dependent Hall (TDH) measurements, and deep level transient spectroscopy (DLTS). The positron lifetime in bulk ZnO is measured to be (151±2)ps and that for positrons trapped in defects (257±2)ps . On the basis of theoretical calculations the latter is attributed to Zn+O divacancies, existing in the sample in neutral charge state, and not to the Zn vacancy proposed in previous experimental work. Their concentration is estimated to be 3.7×1017cm-3 . From TDH measurements the existence of negatively charged intrinsic defects acting as compensating acceptors is concluded which are invisible to positrons—maybe interstitial oxygen. This view is supported from TDH results in combination with DLTS which revealed the creation of the defect E1 , and an increase in concentration of the defect E3 after N+ ion implantation, and peculiarities in the observation of the defect E4 .

  3. Effect of supply voltage and body-biasing on single-event transient pulse quenching in bulk fin field-effect-transistor process

    NASA Astrophysics Data System (ADS)

    Jun-Ting, Yu; Shu-Ming, Chen; Jian-Jun, Chen; Peng-Cheng, Huang; Rui-Qiang, Song

    2016-04-01

    Charge sharing is becoming an important topic as the feature size scales down in fin field-effect-transistor (FinFET) technology. However, the studies of charge sharing induced single-event transient (SET) pulse quenching with bulk FinFET are reported seldomly. Using three-dimensional technology computer aided design (3DTCAD) mixed-mode simulations, the effects of supply voltage and body-biasing on SET pulse quenching are investigated for the first time in bulk FinFET process. Research results indicate that due to an enhanced charge sharing effect, the propagating SET pulse width decreases with reducing supply voltage. Moreover, compared with reverse body-biasing (RBB), the circuit with forward body-biasing (FBB) is vulnerable to charge sharing and can effectively mitigate the propagating SET pulse width up to 53% at least. This can provide guidance for radiation-hardened bulk FinFET technology especially in low power and high performance applications. Project supported by the National Natural Science Foundation of China (Grant Nos. 61376109, 61434007, and 61176030).

  4. Parametric Testing of Chevrons on Single Flow Hot Jets

    NASA Technical Reports Server (NTRS)

    Bridges, James; Brown, Clifford A.

    2004-01-01

    A parametric family of chevron nozzles have been studied, looking for relationships between chevron geometric parameters, flow characteristics, and far-field noise. Both cold and hot conditions have been run at acoustic Mach number 0.9. Ten models have been tested, varying chevron count, penetration, length, and chevron symmetry. Four comparative studies were defined from these datasets which show: that chevron length is not a major impact on either flow or sound; that chevron penetration increases noise at high frequency and lowers it at low frequency, especially for low chevron counts; that chevron count is a strong player with good low frequency reductions being achieved with high chevron count without strong high frequency penalty; and that chevron asymmetry slightly reduces the impact of the chevron. Finally, it is shown that although the hot jets differ systematically from the cold one, the overall trends with chevron parameters is the same.

  5. Initial Neutronics Analyses for HEU to LEU Fuel Conversion of the Transient Reactor Test Facility (TREAT) at the Idaho National Laboratory

    SciTech Connect

    Kontogeorgakos, D.; Derstine, K.; Wright, A.; Bauer, T.; Stevens, J.

    2013-06-01

    The purpose of the TREAT reactor is to generate large transient neutron pulses in test samples without over-heating the core to simulate fuel assembly accident conditions. The power transients in the present HEU core are inherently self-limiting such that the core prevents itself from overheating even in the event of a reactivity insertion accident. The objective of this study was to support the assessment of the feasibility of the TREAT core conversion based on the present reactor performance metrics and the technical specifications of the HEU core. The LEU fuel assembly studied had the same overall design, materials (UO2 particles finely dispersed in graphite) and impurities content as the HEU fuel assembly. The Monte Carlo N–Particle code (MCNP) and the point kinetics code TREKIN were used in the analyses.

  6. DESIGN AND PERFORMANCE OBJECTIVES OF THE SINGLE CELL TEST SYSTEM FOR SO2 DEPOLARIZED ELECTROLYZER DEVELOPMENT

    SciTech Connect

    Steimke, J

    2007-01-15

    The single cell test system development for the SRNL sulfur dioxide-depolarized electrolyzer has been completed. Operating experience and improved operating procedures were developed during test operations in FY06 and the first quarter of FY07. Eight different cell configurations, using various MEA designs, have been tested. The single cell test electrolyzer has been modified to overcome difficulties experienced during testing, including modifications to the inlet connection to eliminate minute acid leaks that caused short circuits. The test facility was modified by adding a water bath for cell heating, thus permitting operation over a wider range of flowrates and cell temperatures. Modifications were also identified to permit continuous water flushing of the cathode to remove sulfur, thus extending operating time between required shutdowns. This is also expected to permit a means of independently measuring the rate of sulfur formation, and the corresponding SO{sub 2} flux through the membrane. This report contains a discussion of the design issues being addressed by the single cell test program, a test matrix being conducted to address these issues, and a summary of the performance objectives for the single cell test system. The current primary objective of single cell test system is to characterize and qualify electrolyzer configurations for the following 100-hour longevity tests. Although the single cell test system development is considered complete, SRNL will continue to utilize the test facility and the single cell electrolyzer to measure the operability and performance of various cell design configurations, including new MEA's produced by the component development tasks.

  7. Single versus successive pop-in modes in nanoindentation tests of single crystals

    SciTech Connect

    Xia, Yuzhi; Gao, Yanfei; Pharr, George M.; Bei, Hongbin

    2016-05-24

    From recent nanoindentation experiments, two types of pop-in modes have been identified: a single pop-in with a large displacement excursion, or a number of pop-ins with comparable and small displacement excursions. Theoretical analyses are developed here to study the roles played by indenter tip radius, pre-existing defect density, heterogeneous nucleation source type, and lattice resistance on the pop-in modes. The evolution of dislocation structures in earlier pop-ins provides input to modeling a stochastic, heterogeneous mechanism that may be responsible for the subsequent pop-ins. It is found that when the first pop-in occurs near theoretical shear stress, the pop-in mode is determined by the lattice resistance and tip radius. When the first pop-in occurs at low shear stress, whether the successive pop-in mode occurs depends on how the heterogeneous dislocation nucleation source density increases as compared to the increase of the total dislocation density. Lastly, the above transitions are found to correlate well with the ratio of indenter tip radius to the mean spacing of dislocation nucleation sources.

  8. Single versus successive pop-in modes in nanoindentation tests of single crystals

    DOE PAGES

    Xia, Yuzhi; Gao, Yanfei; Pharr, George M.; ...

    2016-05-24

    From recent nanoindentation experiments, two types of pop-in modes have been identified: a single pop-in with a large displacement excursion, or a number of pop-ins with comparable and small displacement excursions. Theoretical analyses are developed here to study the roles played by indenter tip radius, pre-existing defect density, heterogeneous nucleation source type, and lattice resistance on the pop-in modes. The evolution of dislocation structures in earlier pop-ins provides input to modeling a stochastic, heterogeneous mechanism that may be responsible for the subsequent pop-ins. It is found that when the first pop-in occurs near theoretical shear stress, the pop-in mode ismore » determined by the lattice resistance and tip radius. When the first pop-in occurs at low shear stress, whether the successive pop-in mode occurs depends on how the heterogeneous dislocation nucleation source density increases as compared to the increase of the total dislocation density. Lastly, the above transitions are found to correlate well with the ratio of indenter tip radius to the mean spacing of dislocation nucleation sources.« less

  9. Advanced development of the spectrum sciences Model 5005-TF, single-event test fixture

    SciTech Connect

    Ackermann, M.R.; Browning, J.S. ); Hughlock, B.W. ); Lum, G.K. ); Tsacoyeanes, W.C. Lab., Inc., Cambridge, MA ); Weeks, M.D. )

    1990-09-01

    This report summarizes the advanced development of the Spectrum Sciences Model 5005-TF, Single-Event Test Fixture. The Model 5005-TF uses a Californium-252 (Cf-252) fission-fragment source to test integrated circuits and other devices for the effects of single-event phenomena. Particle identification methods commonly used in high-energy physics research and nuclear engineering have been incorporated into the Model 5005-TF for estimating the particle charge, mass, and energy parameters. All single-event phenomena observed in a device under test (DUT) are correlated with an identified fission fragment, and its linear energy transfer (LET) and range in the semiconductor material of the DUT.

  10. 10 CFR 26.165 - Testing split specimens and retesting single specimens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... confirmatory creatinine and confirmatory specific gravity tests, when retesting an aliquot of a single specimen or testing Bottle B of a split specimen, to reconfirm that the creatinine concentration was less than.... The second laboratory may only conduct the confirmatory creatinine and specific gravity tests...

  11. Independent Single Event Upset Testing of the Xilinx V5QV

    NASA Technical Reports Server (NTRS)

    Berg, Melanie D.; Label, Kenneth A.; Kim, Hak; Phan, Anthony; Seidleck, Christina

    2014-01-01

    In this presentation, we provide a brief glimpse at preliminary single event test results taken from two years of testing of the Xilinx V5QV Field Programmable Gate Array (FPGA). This presentation includes an overview of test philosophy and implementation.

  12. Psychometric Characteristics of Single-Word Tests of Children's Speech Sound Production

    ERIC Educational Resources Information Center

    Flipsen, Peter, Jr.; Ogiela, Diane A.

    2015-01-01

    Purpose: Our understanding of test construction has improved since the now-classic review by McCauley and Swisher (1984) . The current review article examines the psychometric characteristics of current single-word tests of speech sound production in an attempt to determine whether our tests have improved since then. It also provides a resource…

  13. Testing the necessity of transient spikes in the drivers for creating a storm-time ring current

    NASA Astrophysics Data System (ADS)

    Liemohn, M. W.; Ilie, R.; Ridley, A. J.; Kozyra, J. U.; Thomsen, M. F.; Borovsky, J. E.

    2007-12-01

    The role of transient spikes in upstream solar wind parameters and near-Earth plasma sheet parameters is investigated through a series of numerical simulations. During magnetic storms, the near-Earth plasma sheet density (as observed at geosynchronous altitude) is often enhanced relative to its normal, quiescent level. In addition to a baseline increase of the density of up to a few per cubic centimeter lasting several hours, there are usually short-lived (a few to tens of minutes) increases on top of this (up to double the baseline). In addition, the solar wind parameters also often have numerous short-lived spikes and fluctuations within it. The question then arises of the relative contribution of these transient spikes in the drivers to the storm-time ring current intensity. To address this issue, a series of simulations are conducted using the Hot Electron and Ion Drift Integrator (HEIDI) model (formerly the Michigan version of RAM). Various running averages of the upstream solar wind conditions and geosynchronous orbit nightside boundary conditions are used to drive HEIDI. It is found that the spikes are simply adding a linear contribution to the ring current intensity over the baseline (averaged) input levels, and that any nonlinear influences occur beyond the HEIDI simulation domain (i.e., at high latitudes or in the tail). That is, the spikes do not last long enough to develop nonlinear influences on the ring current's total energy content. The HEIDI results are compared against global magnetospheric modeling results using averaged input parameters into the Space Weather Modeling Framework (SWMF), which show a nonlinear response to transient spikes.

  14. Compendium of Recent Test Results of Single Event Effects Conducted by the Jet Propulsion Laboratory

    NASA Technical Reports Server (NTRS)

    Allen, Gregory R.; Guertin, Steven M.; Scheick, Leif Z.; Irom, Farokh; Zajac, Stephanie

    2012-01-01

    This paper reports heavy ion, proton, and laser induced single event effects results for a variety of microelectronic devices targeted for possible use in NASA spacecrafts. The compendium covers devices tested within the years of 2010 through 2012.

  15. α1H mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice

    PubMed Central

    Berthier, Christine; Monteil, Arnaud; Lory, Philippe; Strube, Caroline

    2002-01-01

    Calcium channels are essential for excitation-contraction coupling and muscle development. At the end of fetal life, two types of Ca2+ currents can be recorded in muscle cells. Whereas L-type Ca2+ channels have been extensively studied, T-type channels have been poorly characterized in skeletal muscle. We describe here the functional and molecular properties of T-type calcium channels in developing mouse skeletal muscle. The T-type current density increased transiently during prenatal myogenesis with a maximum at embryonic day E16 followed by a drastic decrease until birth. This current showed similar electrophysiological and pharmacological properties at all examined stages. It displayed a wide window current centred at about −35 and −55 mV in 10 and 2 mm external Ca2+, respectively. Activation and inactivation kinetics were fast (3 and 16 ms, respectively). The current was inhibited by nickel and amiloride with an IC50 of 5.4 and 156 μm, respectively, values similar to those described for cloned T-type α1H channels. Whole muscle tissue RT-PCR analysis revealed mRNAs corresponding to α1H and α1G subunits in the fetus but not in the adult. However, single-fibre RT-PCR demonstrated that only α1H mRNA was present in prenatal fibres, suggesting that the α1G transcript present in muscle tissue must be expressed by non-skeletal muscle cells. Altogether, these results demonstrate that the α1H subunit generates functional T-type calcium channels in developing skeletal muscle fibres and suggest that these channels are involved in the early stages of muscle differentiation. PMID:11897840

  16. Myelin Water Fraction Is Transiently Reduced after a Single Mild Traumatic Brain Injury – A Prospective Cohort Study in Collegiate Hockey Players

    PubMed Central

    Vavasour, Irene; Shahinfard, Elham; Kolind, Shannon; van Donkelaar, Paul; Taunton, Jack; Li, David; Rauscher, Alexander

    2016-01-01

    Impact-related mild traumatic brain injuries (mTBI) are a major public health concern, and remain as one of the most poorly understood injuries in the field of neuroscience. Currently, the diagnosis and management of such injuries are based largely on patient-reported symptoms. An improved understanding of the underlying pathophysiology of mTBI is urgently needed in order to develop better diagnostic and management protocols. Specifically, dynamic post-injury changes to the myelin sheath in the human brain have not been examined, despite ‘compromised white matter integrity’ often being described as a consequence of mTBI. In this preliminary cohort study, myelin water imaging was used to prospectively evaluate changes in myelin water fraction, derived from the T2 decay signal, in two varsity hockey teams (45 players) over one season of athletic competition. 11 players sustained a concussion during competition, and were scanned at 72 hours, 2 weeks, and 2 months post-injury. Results demonstrated a reduction in myelin water fraction at 2 weeks post-injury in several brain areas relative to preseason scans, including the splenium of the corpus callosum, right posterior thalamic radiation, left superior corona radiata, left superior longitudinal fasciculus, and left posterior limb of the internal capsule. Myelin water fraction recovered to pre-season values by 2 months post-injury. These results may indicate transient myelin disruption following a single mTBI, with subsequent remyelination of affected neurons. Myelin disruption was not apparent in the athletes who did not experience a concussion, despite exposure to repetitive subconcussive trauma over a season of collegiate hockey. These findings may help to explain many of the metabolic and neurological deficits observed clinically following mTBI. PMID:26913900

  17. Single-Event Upset Testing of the Performance Semiconductor 1750A CMOS/ SOS Chip Set

    DTIC Science & Technology

    1993-09-30

    In addition, long event upset test computer is a single - board computer made cables are more sensitive to electrical noise. by Silicon Composers and...microprocessors PACE I 750A chip set was individually irradiated by mov- mounted in a single - board computer running some ing each device into the beam

  18. 76 FR 34801 - Petition for Modification of Single Car Air Brake Test Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... Federal Railroad Administration Petition for Modification of Single Car Air Brake Test Procedures In... (PATH) has requested the Federal Railroad Administration (FRA) grant a modification of the single car... FRA-2010-0174. PATH operates a fleet of 25 flat cars in consist with revenue cars utilized...

  19. ARMCOM Red Team Role in The Single Integrated Development Test Cycle

    DTIC Science & Technology

    1975-11-01

    USADACS Tdv*c* Ubrtry RIA-76-U146 5 0712 01001238 0 AOA0ivi& ARMCOM RED TEAM ROLE IN THE SINGLE INTEGRATED DEVELOPMENT TEST CYCLE THOMAS N...TITLE (and Subtitle) ARMCOM Red Team Role in The Single Integrated Development Test Cycle. 5. TYPE OF REPORT & PERIOD COVERED Note...per year. In addition to the Red Team function, the Systems Analysis Directorate will also function in the Blue Team role to support the developer

  20. LUNAR OUTGASSING, TRANSIENT PHENOMENA, AND THE RETURN TO THE MOON. II. PREDICTIONS AND TESTS FOR OUTGASSING/REGOLITH INTERACTIONS

    SciTech Connect

    Crotts, Arlin P. S.; Hummels, Cameron

    2009-12-20

    We follow Paper I with predictions of how gas leaking through the lunar surface could influence the regolith, as might be observed via optical transient lunar phenomena (TLPs) and related effects. We touch on several processes, but concentrate on low and high flow rate extremes, which are perhaps the most likely. We model explosive outgassing for the smallest gas overpressure at the regolith base that releases the regolith plug above it. This disturbance's timescale and affected area are consistent with observed TLPs; we also discuss other effects. For slow flow, escape through the regolith is prolonged by low diffusivity. Water, found recently in deep magma samples, is unique among candidate volatiles, capable of freezing between the regolith base and surface, especially near the lunar poles. For major outgassing sites, we consider the possible accumulation of water ice. Over geological time, ice accumulation can evolve downward through the regolith. Depending on gases additional to water, regolith diffusivity might be suppressed chemically, blocking seepage and forcing the ice zone to expand to larger areas, up to km{sup 2} scales, again, particularly at high latitudes. We propose an empirical path forward, wherein current and forthcoming technologies provide controlled, sensitive probes of outgassing. The optical transient/outgassing connection, addressed via Earth-based remote sensing, suggests imaging and/or spectroscopy, but aspects of lunar outgassing might be more covert, as indicated above. TLPs betray some outgassing, but does outgassing necessarily produce TLPs? We also suggest more intrusive techniques from radar to in situ probes. Understanding lunar volatiles seems promising in terms of resource exploitation for human exploration of the Moon and beyond, and offers interesting scientific goals in its own right. Many of these approaches should be practiced in a pristine lunar atmosphere, before significant confusing signals likely to be produced upon

  1. The Influence of Age on Interaction between Breath-Holding Test and Single-Breath Carbon Dioxide Test.

    PubMed

    Trembach, Nikita; Zabolotskikh, Igor

    2017-01-01

    Introduction. The aim of the study was to compare the breath-holding test and single-breath carbon dioxide test in evaluation of the peripheral chemoreflex sensitivity to carbon dioxide in healthy subjects of different age. Methods. The study involved 47 healthy volunteers between ages of 25 and 85 years. All participants were divided into 4 groups according to age: 25 to 44 years (n = 14), 45 to 60 years (n = 13), 60 to 75 years (n = 12), and older than 75 years (n = 8). Breath-holding test was performed in the morning before breakfast. The single-breath carbon dioxide (SB-CO2) test was performed the following day. Results. No correlation was found between age and duration of breath-holding (r = 0.13) and between age and peripheral chemoreflex sensitivity to CO2 (r = 0.07). In all age groups there were no significant differences in the mean values from the breath-holding test and peripheral chemoreflex sensitivity tests. In all groups there was a strong significant inverse correlation between breath-holding test and SB-CO2 test. Conclusion. A breath-holding test reflects the sensitivity of the peripheral chemoreflex to carbon dioxide in healthy elderly humans. Increasing age alone does not alter the peripheral ventilatory response to hypercapnia.

  2. The Influence of Age on Interaction between Breath-Holding Test and Single-Breath Carbon Dioxide Test

    PubMed Central

    Zabolotskikh, Igor

    2017-01-01

    Introduction. The aim of the study was to compare the breath-holding test and single-breath carbon dioxide test in evaluation of the peripheral chemoreflex sensitivity to carbon dioxide in healthy subjects of different age. Methods. The study involved 47 healthy volunteers between ages of 25 and 85 years. All participants were divided into 4 groups according to age: 25 to 44 years (n = 14), 45 to 60 years (n = 13), 60 to 75 years (n = 12), and older than 75 years (n = 8). Breath-holding test was performed in the morning before breakfast. The single-breath carbon dioxide (SB-CO2) test was performed the following day. Results. No correlation was found between age and duration of breath-holding (r = 0.13) and between age and peripheral chemoreflex sensitivity to CO2 (r = 0.07). In all age groups there were no significant differences in the mean values from the breath-holding test and peripheral chemoreflex sensitivity tests. In all groups there was a strong significant inverse correlation between breath-holding test and SB-CO2 test. Conclusion. A breath-holding test reflects the sensitivity of the peripheral chemoreflex to carbon dioxide in healthy elderly humans. Increasing age alone does not alter the peripheral ventilatory response to hypercapnia. PMID:28251147

  3. Status of High Power Tests of Normal Conducting Single-Cell Structures

    SciTech Connect

    Dolgashev, V.A.; Tantawi, S.G.; Higashi, Y.; Higo, T.; /KEK, Tsukuba

    2011-11-04

    We report the results of ongoing high power tests of single-cell standing wave structures. These tests are part of an experimental and theoretical study of rf breakdown in normal conducting structures at 11.4 GHz. The goal of this study is to determine the maximum gradient possibilities for normal-conducting rf powered particle beam accelerators. The test setup consists of reusable mode launchers and short test structures powered by SLACs XL-4 klystron. The mode launchers and structures were manufactured at SLAC and KEK and tested at the SLAC klystron test laboratory.

  4. The Influence of Sarcoplasmic Reticulum Ca2+ Concentration on Ca2+ Sparks and Spontaneous Transient Outward Currents in Single Smooth Muscle Cells

    PubMed Central

    ZhuGe, Ronghua; Tuft, Richard A.; Fogarty, Kevin E.; Bellve, Karl; Fay, Fredric S.; Walsh, John V.

    1999-01-01

    Localized, transient elevations in cytosolic Ca2+, known as Ca2+ sparks, caused by Ca2+ release from sarcoplasmic reticulum, are thought to trigger the opening of large conductance Ca2+-activated potassium channels in the plasma membrane resulting in spontaneous transient outward currents (STOCs) in smooth muscle cells. But the precise relationships between Ca2+ concentration within the sarcoplasmic reticulum and a Ca2+ spark and that between a Ca2+ spark and a STOC are not well defined or fully understood. To address these problems, we have employed two approaches using single patch-clamped smooth muscle cells freshly dissociated from toad stomach: a high speed, wide-field imaging system to simultaneously record Ca2+ sparks and STOCs, and a method to simultaneously measure free global Ca2+ concentration in the sarcoplasmic reticulum ([Ca2+]SR) and in the cytosol ([Ca2+]CYTO) along with STOCs. At a holding potential of 0 mV, cells displayed Ca2+ sparks and STOCs. Ca2+ sparks were associated with STOCs; the onset of the sparks coincided with the upstroke of STOCs, and both had approximately the same decay time. The mean increase in [Ca2+]CYTO at the time and location of the spark peak was ∼100 nM above a resting concentration of ∼100 nM. The frequency and amplitude of spontaneous Ca2+ sparks recorded at −80 mV were unchanged for a period of 10 min after removal of extracellular Ca2+ (nominally Ca2+-free solution with 50 μM EGTA), indicating that Ca2+ influx is not necessary for Ca2+sparks. A brief pulse of caffeine (20 mM) elicited a rapid decrease in [Ca2+]SR in association with a surge in [Ca2+]CYTO and a fusion of STOCs, followed by a fast restoration of [Ca2+]CYTO and a gradual recovery of [Ca2+]SR and STOCs. The return of global [Ca2+]CYTO to rest was an order of magnitude faster than the refilling of the sarcoplasmic reticulum with Ca2+. After the global [Ca2+]CYTO was fully restored, recovery of STOC frequency and amplitude were correlated with the

  5. Robust inference from multiple test statistics via permutations: a better alternative to the single test statistic approach for randomized trials.

    PubMed

    Ganju, Jitendra; Yu, Xinxin; Ma, Guoguang Julie

    2013-01-01

    Formal inference in randomized clinical trials is based on controlling the type I error rate associated with a single pre-specified statistic. The deficiency of using just one method of analysis is that it depends on assumptions that may not be met. For robust inference, we propose pre-specifying multiple test statistics and relying on the minimum p-value for testing the null hypothesis of no treatment effect. The null hypothesis associated with the various test statistics is that the treatment groups are indistinguishable. The critical value for hypothesis testing comes from permutation distributions. Rejection of the null hypothesis when the smallest p-value is less than the critical value controls the type I error rate at its designated value. Even if one of the candidate test statistics has low power, the adverse effect on the power of the minimum p-value statistic is not much. Its use is illustrated with examples. We conclude that it is better to rely on the minimum p-value rather than a single statistic particularly when that single statistic is the logrank test, because of the cost and complexity of many survival trials.

  6. Technical Progress Report on Single Pass Flow Through Tests of Ceramic Waste Forms for Plutonium Immobilization

    SciTech Connect

    Zhao, P.; Roberts, S.; Bourcier, W.L.

    2000-12-03

    This report updates work on measurements of the dissolution rates of single-phase and multi-phase ceramic waste forms in flow-through reactors at Lawrence Livermore National Laboratory. Previous results were reported in Bourcier (1999). Two types of tests are in progress: (1) tests of baseline pyrochlore-based multiphase ceramics; and (2) tests of single-phase pyrochlore, zirconolite, and brannerite (the three phases that will contain most of the actinides). Tests of the multi-phase material are all being run at 25 C. The single-phase tests are being run at 25, 50, and 75 C. All tests are being performed at ambient pressure. The as-made bulk compositions of the ceramics are given in Table 1. The single pass flow-through test procedure [Knauss, 1986 No.140] allows the powdered ceramic to react with pH buffer solutions traveling upward vertically through the powder. Gentle rocking during the course of the experiment keeps the powder suspended and avoids clumping, and allows the system to behave as a continuously stirred reactor. For each test, a cell is loaded with approximately one gram of the appropriate size fraction of powdered ceramic and reacted with a buffer solution of the desired pH. The buffer solution compositions are given in Table 2. All the ceramics tested were cold pressed and sintered at 1350 C in air, except brannerite, which was sintered at 1350 C in a CO/CO{sub 2} gas mixture. They were then crushed, sieved, rinsed repeatedly in alcohol and distilled water, and the desired particle size fraction collected for the single pass flow-through tests (SPFT). The surface area of the ceramics measured by BET ranged from 0.1-0.35 m{sup 2}/g. The measured surface area values, average particle size, and sample weights for each ceramic test are given in the Appendices.

  7. Extensions of a Versatile Randomization Test for Assessing Single-Case Intervention Effects

    ERIC Educational Resources Information Center

    Levin, Joel R.; Lall, Venessa F.; Kratochwill, Thomas R.

    2011-01-01

    The purpose of the present study was to investigate the statistical properties of two extensions of the Levin-Wampold (1999) single-case simultaneous start-point model's comparative effectiveness randomization test. The two extensions were (a) adapting the test to situations where there are more than two different intervention conditions and (b)…

  8. Analytical solutions for efficient interpretation of single-well push-pull tracer tests

    EPA Science Inventory

    Single-well push-pull tracer tests have been used to characterize the extent, fate, and transport of subsurface contamination. Analytical solutions provide one alternative for interpreting test results. In this work, an exact analytical solution to two-dimensional equations descr...

  9. MULTIMOMENT RADIO TRANSIENT DETECTION

    SciTech Connect

    Spitler, L. G.; Cordes, J. M.; Chatterjee, S.; Stone, J.

    2012-04-01

    We present a multimoment technique for signal classification and apply it to the detection of fast radio transients in incoherently dedispersed data. Specifically, we define a spectral modulation index in terms of the fractional variation in intensity across a spectrum. A signal whose intensity is distributed evenly across the entire band has a lower modulation index than a spectrum whose intensity is localized in a single channel. We are interested in broadband pulses and use the modulation index to excise narrowband radio frequency interference by applying a modulation index threshold above which candidate events are removed. The technique is tested both with simulations and using data from known sources of radio pulses (RRAT J1928+15 and giant pulses from the Crab pulsar). The method is generalized to coherent dedispersion, image cubes, and astrophysical narrowband signals that are steady in time. We suggest that the modulation index, along with other statistics using higher order moments, should be incorporated into signal detection pipelines to characterize and classify signals.

  10. Characterization of single crystal mechanical test specimens for advanced turbine applications

    NASA Astrophysics Data System (ADS)

    Lipetzky, Kirsten G.; Green, Robert E.

    1999-12-01

    A series of fifteen mechanical test specimens made from a nickel-based superalloy were supplied by Siemens Westinghouse in order that Asymmetric Crystal Topography (ACT), an x-ray diffraction technique, be used to confirm which samples were single crystal samples and which samples contained low angle grain boundaries. It had been determined (by another investigator) prior to the manufacture of the mechanical test specimens, which "raw" material contained low angle grain boundaries and which material was single crystalline in nature. Siemens Westinghouse requisitioned the production of mechanical test specimens from several manufacturers, with specific requirements that some of the samples were to be single crystalline and that other samples were to contain low angle grain boundaries within the gauge length. Once completed, Siemens Westinghouse wanted to confirm that the samples were properly manufactured and selected a representative portion of the mechanical test samples to be examined via ACT.

  11. A Nuclear Interaction Model for Understanding Results of Single Event Testing with High Energy Protons

    NASA Technical Reports Server (NTRS)

    Culpepper, William X.; ONeill, Pat; Nicholson, Leonard L.

    2000-01-01

    An internuclear cascade and evaporation model has been adapted to estimate the LET spectrum generated during testing with 200 MeV protons. The model-generated heavy ion LET spectrum is compared to the heavy ion LET spectrum seen on orbit. This comparison is the basis for predicting single event failure rates from heavy ions using results from a single proton test. Of equal importance, this spectra comparison also establishes an estimate of the risk of encountering a failure mode on orbit that was not detected during proton testing. Verification of the general results of the model is presented based on experiments, individual part test results, and flight data. Acceptance of this model and its estimate of remaining risk opens the hardware verification philosophy to the consideration of radiation testing with high energy protons at the board and box level instead of the more standard method of individual part testing with low energy heavy ions.

  12. A comparison of single-cycle versus multi-cycle proof testing strategies

    NASA Technical Reports Server (NTRS)

    Hudak, Stephen J., Jr.; Russell, Dale A.

    1988-01-01

    Proof testing was a useful supplement to conventional nondestructive evaluation (NDE) of space shuttle main engine (SSME) components. Since many of these components involve thin sections and high toughness materials, such as Inconel 718, conventional single-cycle proof test logic is not applicable due to the propensity for stable crack growth during the proof tests. Experience with five-cycle proof testing of SSME components is summarized and a framework is outlined for understanding multi-cycle proof testing using the fracture mechanics concept of a resistance curve. Extreme value statistics are also used to propose an empirical approach to compare the advantages and disadvantages of single- versus multi-cycle proof testing. The importance of the initial flaw size distribution and specimen thickness in such a comparison is also discussed.

  13. A single electromyographic testing point is valid to monitor neuromuscular fatigue during continuous exercise.

    PubMed

    Galen, Sujay S; Malek, Moh H

    2014-10-01

    Two different protocols for estimating the electromyographic fatigue threshold (EMGFT) have been proposed in the literature. These protocols are distinguished by the number of visits required to determine the EMGFT. The purpose of this study, therefore, was to statistically compare the estimated EMGFT from the single-visit incremental test and the multiple-visit constant workload tests for single-leg knee-extensor exercise. Seven healthy college-aged men [mean ± SEM; age = 25.0 ± 0.7 years] performed the incremental test and on separate occasions also performed 4 constant workload tests to voluntary exhaustion. The EMG amplitude was recorded from the rectus femoris muscle during all the testing sessions. For the single-visit test, the EMG amplitude vs. time relationship for each power output was examined using linear regression. For the multiple-visit tests, the EMG amplitude vs. time relationship was calculated for each constant power output. Thereafter, the power outputs were plotted as a function of the slope coefficient for the EMG amplitude vs. time relationships, and linear regression was performed. The EMGFT was defined as the intersection of the regression line with the y-intercept of the power output vs. slope coefficient plot. The results indicated that the estimated EMGFT from the single-visit test was significantly (p = 0.012) lower than the estimate from the multiple-visit tests. Because this test is performed during a single visit and concludes within 20 minutes, it may also have application in clinical rehabilitation settings and not merely for an athletic population.

  14. Incorporating Single-Locus Tests into Haplotype Cladistic Analysis in Case-Control Studies

    PubMed Central

    Liu, Jianfeng; Papasian, Chris; Deng, Hong-Wen

    2007-01-01

    In case-control studies, genetic associations for complex diseases may be probed either with single-locus tests or with haplotype-based tests. Although there are different views on the relative merits and preferences of the two test strategies, haplotype-based analyses are generally believed to be more powerful to detect genes with modest effects. However, a main drawback of haplotype-based association tests is the large number of distinct haplotypes, which increases the degrees of freedom for corresponding test statistics and thus reduces the statistical power. To decrease the degrees of freedom and enhance the efficiency and power of haplotype analysis, we propose an improved haplotype clustering method that is based on the haplotype cladistic analysis developed by Durrant et al. In our method, we attempt to combine the strengths of single-locus analysis and haplotype-based analysis into one single test framework. Novel in our method is that we develop a more informative haplotype similarity measurement by using p-values obtained from single-locus association tests to construct a measure of weight, which to some extent incorporates the information of disease outcomes. The weights are then used in computation of similarity measures to construct distance metrics between haplotype pairs in haplotype cladistic analysis. To assess our proposed new method, we performed simulation analyses to compare the relative performances of (1) conventional haplotype-based analysis using original haplotype, (2) single-locus allele-based analysis, (3) original haplotype cladistic analysis (CLADHC) by Durrant et al., and (4) our weighted haplotype cladistic analysis method, under different scenarios. Our weighted cladistic analysis method shows an increased statistical power and robustness, compared with the methods of haplotype cladistic analysis, single-locus test, and the traditional haplotype-based analyses. The real data analyses also show that our proposed method has practical

  15. RECENT ADVANCES IN HIGH TEMPERATURE ELECTROLYSIS AT IDAHO NATIONAL LABORATORY: SINGLE CELL TESTS

    SciTech Connect

    X. Zhang; J. E. O'Brien; R. C. O'Brien

    2012-07-01

    An experimental investigation on the performance and durability of single solid oxide electrolysis cells (SOECs) is under way at the Idaho National Laboratory. In order to understand and mitigate the degradation issues in high temperature electrolysis, single SOECs with different configurations from several manufacturers have been evaluated for initial performance and long-term durability. A new test apparatus has been developed for single cell and small stack tests from different vendors. Single cells from Ceramatec Inc. show improved durability compared to our previous stack tests. Single cells from Materials and Systems Research Inc. (MSRI) demonstrate low degradation both in fuel cell and electrolysis modes. Single cells from Saint Gobain Advanced Materials (St. Gobain) show stable performance in fuel cell mode, but rapid degradation in the electrolysis mode. Electrolyte-electrode delamination is found to have significant impact on degradation in some cases. Enhanced bonding between electrolyte and electrode and modification of the microstructure help to mitigate degradation. Polarization scans and AC impedance measurements are performed during the tests to characterize the cell performance and degradation.

  16. Space Power Facility-Capabilities for Space Environmental Testing Within a Single Facility

    NASA Technical Reports Server (NTRS)

    Sorge, Richard N.

    2013-01-01

    The purpose of this paper is to describe the current and near-term environmental test capabilities of the NASA Glenn Research Center's Space Power Facility (SPF) located at Sandusky, Ohio. The paper will present current and near-term capabilities for conducting electromagnetic interference and compatibility testing, base-shake sinusoidal vibration testing, reverberant acoustic testing, and thermal-vacuum testing. The paper will also present modes of transportation, handling, ambient environments, and operations within the facility to conduct those tests. The SPF is in the midst of completing and activating new or refurbished capabilities which, when completed, will provide the ability to conduct most or all required full-scale end-assembly space simulation tests at a single test location. It is envisioned that the capabilities will allow a customer to perform a wide range of space simulation tests in one facility at reasonable cost.

  17. Advanced sluicing system test report for single shell tank waste retrieval integrated testing

    SciTech Connect

    Berglin, E.J.

    1997-05-29

    This document describes the testing performed by ARD Environmental, Inc., and Los Alamos Technical Associates of the LATA/ARD Advanced Sluicing System, in support of ACTR Phase 1 activities. Testing was to measure the impact force and pressures of sluicing streams at three different distances, as measured by the Government supplied load cell. Simulated sluicing of large simulated salt cake and hard pan waste coupons was also performed. Due to operational difficulties experienced with the Government supplied load cell, no meaningful results with respect to sluice stream impact pressure distribution or stream coherence were obtained. Sluice testing using 3000 psi salt cake simulants measured waste retrieval rates of approximately 12 Ml/day (17.6 ft{sup 3}/hr). Rates as high as 314 m{sup 3}/day (463 ft{sup 3}/hr) were measured against the lower strength salt cake simulants.

  18. Comparative performance of four single extreme outlier discordancy tests from Monte Carlo simulations.

    PubMed

    Verma, Surendra P; Díaz-González, Lorena; Rosales-Rivera, Mauricio; Quiroz-Ruiz, Alfredo

    2014-01-01

    Using highly precise and accurate Monte Carlo simulations of 20,000,000 replications and 102 independent simulation experiments with extremely low simulation errors and total uncertainties, we evaluated the performance of four single outlier discordancy tests (Grubbs test N2, Dixon test N8, skewness test N14, and kurtosis test N15) for normal samples of sizes 5 to 20. Statistical contaminations of a single observation resulting from parameters called δ from ±0.1 up to ±20 for modeling the slippage of central tendency or ε from ±1.1 up to ±200 for slippage of dispersion, as well as no contamination (δ = 0 and ε = ±1), were simulated. Because of the use of precise and accurate random and normally distributed simulated data, very large replications, and a large number of independent experiments, this paper presents a novel approach for precise and accurate estimations of power functions of four popular discordancy tests and, therefore, should not be considered as a simple simulation exercise unrelated to probability and statistics. From both criteria of the Power of Test proposed by Hayes and Kinsella and the Test Performance Criterion of Barnett and Lewis, Dixon test N8 performs less well than the other three tests. The overall performance of these four tests could be summarized as N2≅N15 > N14 > N8.

  19. Comparative Performance of Four Single Extreme Outlier Discordancy Tests from Monte Carlo Simulations

    PubMed Central

    Díaz-González, Lorena; Quiroz-Ruiz, Alfredo

    2014-01-01

    Using highly precise and accurate Monte Carlo simulations of 20,000,000 replications and 102 independent simulation experiments with extremely low simulation errors and total uncertainties, we evaluated the performance of four single outlier discordancy tests (Grubbs test N2, Dixon test N8, skewness test N14, and kurtosis test N15) for normal samples of sizes 5 to 20. Statistical contaminations of a single observation resulting from parameters called δ from ±0.1 up to ±20 for modeling the slippage of central tendency or ε from ±1.1 up to ±200 for slippage of dispersion, as well as no contamination (δ = 0 and ε = ±1), were simulated. Because of the use of precise and accurate random and normally distributed simulated data, very large replications, and a large number of independent experiments, this paper presents a novel approach for precise and accurate estimations of power functions of four popular discordancy tests and, therefore, should not be considered as a simple simulation exercise unrelated to probability and statistics. From both criteria of the Power of Test proposed by Hayes and Kinsella and the Test Performance Criterion of Barnett and Lewis, Dixon test N8 performs less well than the other three tests. The overall performance of these four tests could be summarized as N2≅N15 > N14 > N8. PMID:24737992

  20. Columbia University flow instability experimental program: Volume 7. Single tube tests, critical heat flux test program

    SciTech Connect

    Dougherty, T.; Maciuca, C.; McAssey, E.V. Jr.; Reddy, D.G.; Yang, B.W.

    1992-09-01

    This report deals with critical heat flux (CHF) measurements in vertical down flow of water at low pressures in a round Inconel tube, 96 inches long and 0.62 inch inside diameter. A total of 28 CHF points were obtained. These data were found to correlate linearly with the single variable q, defined as the heat flux required to raise the enthalpy from the inlet value to the saturation value. These results were compared to the published results of Swedish investigators for vertical upflow of water at low pressures in round tubes of similar diameters and various lengths. The parameter q depends on the inlet enthalpy and is a nonlocal variable, thus this correlation is nonlocal unless the coefficients depend upon tube length in a particular prescribed manner. For the low pressure Swedish data, the coefficients are practically independent of length and hence the correlation is nonlocal. In the present investigation only one length was employed, so it is not possible to determine whether the correlation for these data is local or nonlocal, although there is reason to believe that it is local. The same correlation was applied to a large data base (thousands of CHF points) compiled from the published data of a number of groups and found to apply, with reasonable accuracy over a wide range of conditions, yielding sometimes local and sometimes nonlocal correlations. The basic philosophy of data analysis here was not to generate a single correlation which would reproduce all data, but to search for correlations which apply adequately over some range and which might have some mechanistic significance. The tentative conclusion is that at least two mechanisms appear operative, leading to two types of correlations, one local, the other nonlocal.

  1. Ambiguity in measuring matrix diffusion with single-well injection/recovery tracer tests

    USGS Publications Warehouse

    Lessoff, S.C.; Konikow, L.F.

    1997-01-01

    Single-well injection/recovery tracer tests are considered for use in characterizing and quantifying matrix diffusion in dual-porosity aquifers. Numerical modeling indicates that neither regional drift in homogeneous aquifers, nor heterogeneity in aquifers having no regional drift, nor hydrodynamic dispersion significantly affects these tests. However, when drift is coupled simultaneously with heterogeneity, they can have significant confounding effects on tracer return. This synergistic effect of drift and heterogeneity may help explain irreversible flow and inconsistent results sometimes encountered in previous single-well injection/recovery tracer tests. Numerical results indicate that in a hypothetical single-well injection/recovery tracer test designed to demonstrate and measure dual-porosity characteristics in a fractured dolomite, the simultaneous effects of drift and heterogeneity sometimes yields responses similar to those anticipated in a homogeneous dual-porosity formation. In these cases, tracer recovery could provide a false indication of the occurrence of matrix diffusion. Shortening the shut-in period between injection and recovery periods may make the test less sensitive to drift. Using multiple tracers having different diffusion characteristics, multiple tests having different pumping schedules, and testing the formation at more than one location would decrease the ambiguity in the interpretation of test data.

  2. Distinction between persistent and transient infection in a bovine viral diarrhoea (BVD) control programme: appropriate interpretation of real-time RT-PCR and antigen-ELISA test results.

    PubMed

    Hanon, J-B; Van der Stede, Y; Antonissen, A; Mullender, C; Tignon, M; van den Berg, T; Caij, B

    2014-04-01

    Control of bovine viral diarrhoea (BVD) in Belgium is currently implemented on a voluntary basis at herd level and mainly relies on detection and culling of persistently infected (PI) animals. The present field study was conducted during the winter of 2010/2011 to assess the performances of diagnostic assays used in the testing scheme for BVD as proposed by the two Belgian regional laboratories. Individual blood samples were collected from 4972 animals, and individual samples from the same herd were pooled (maximum of 30 individual samples per pool) and screened for the presence of Bovine Viral Diarrhoea Virus (BVDV)-specific RNA using a commercial real-time RT-PCR test (ADIAGENE). Individual samples from positive pools were then tested in parallel with the same RT-PCR test and with an antigen-capture ELISA test (IDEXX) to detect viremic animals. This study demonstrated that individual results differed according to the type of assay used (P < 0.001): 140 animals (2.8%) were positive by RT-PCR and 72 (1.4%) by antigen-ELISA. A second blood sample was taken 40 days later from 74 PCR positive animals to detect persistent viremia: 17 (23%) of these were still PCR positive and considered to be PI and the 57 that no longer tested positive were assumed to be transiently infected (TI) animals. All PI animals were positive also by antigen-ELISA at both time points. Among TI animals, 10 (16%) were positive by antigen-ELISA at the first but none at the second sampling. A highly significant difference in cycle threshold (Ct ) values obtained by RT-PCR was observed between PI and TI animals. ROC analysis was performed to establish thresholds to confirm with high probability that an animal is PI, based on the result of RT-PCR test performed on a single individual blood sample.

  3. Crash tests of three identical low-wing single-engine airplane

    NASA Technical Reports Server (NTRS)

    Castle, C. B.; Alfaro-Bou, E.

    1983-01-01

    Three identical four place, low wing single engine airplane specimens with nominal masses of 1043 kg were crash tested under controlled free flight conditions. The tests were conducted at the same nominal velocity of 25 m/sec along the flight path. Two airplanes were crashed on a concrete surface (at 10 and 30 deg pitch angles), and one was crashed on soil (at a -30 deg pitch angle). The three tests revealed that the specimen in the -30 deg test on soil sustained massive structural damage in the engine compartment and fire wall. Also, the highest longitudinal cabin floor accelerations occurred in this test. Severe damage, but of lesser magnitude, occurred in the -30 deg test on concrete. The highest normal cabin floor accelerations occurred in this test. The least structural damage and lowest accelerations occurred in the 10 deg test on concrete.

  4. Single Event Effects Test Facility Options at the Oak Ridge National Laboratory

    SciTech Connect

    Riemer, Bernie; Gallmeier, Franz X; Dominik, Laura J

    2015-01-01

    Increasing use of microelectronics of ever diminishing feature size in avionics systems has led to a growing Single Event Effects (SEE) susceptibility arising from the highly ionizing interactions of cosmic rays and solar particles. Single event effects caused by atmospheric radiation have been recognized in recent years as a design issue for avionics equipment and systems. To ensure a system meets all its safety and reliability requirements, SEE induced upsets and potential system failures need to be considered, including testing of the components and systems in a neutron beam. Testing of integrated circuits (ICs) and systems for use in radiation environments requires the utilization of highly advanced laboratory facilities that can run evaluations on microcircuits for the effects of radiation. This paper provides a background of the atmospheric radiation phenomenon and the resulting single event effects, including single event upset (SEU) and latch up conditions. A study investigating requirements for future single event effect irradiation test facilities and developing options at the Spallation Neutron Source (SNS) is summarized. The relatively new SNS with its 1.0 GeV proton beam, typical operation of 5000 h per year, expertise in spallation neutron sources, user program infrastructure, and decades of useful life ahead is well suited for hosting a world-class SEE test facility in North America. Emphasis was put on testing of large avionics systems while still providing tunable high flux irradiation conditions for component tests. Makers of ground-based systems would also be served well by these facilities. Three options are described; the most capable, flexible, and highest-test-capacity option is a new stand-alone target station using about one kW of proton beam power on a gas-cooled tungsten target, with dual test enclosures. Less expensive options are also described.

  5. Characterizing SI Engine Transient Fuel Consumption in ALPHA

    EPA Science Inventory

    Examine typical transient engine operation encountered over the EPA's vehicle and engine testing drive cycles to characterize that transient fuel usage, and then describe the changes made to ALPHA to better model transient engine operation.

  6. Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease.

    PubMed

    Wormser, Gary P; Schriefer, Martin; Aguero-Rosenfeld, Maria E; Levin, Andrew; Steere, Allen C; Nadelman, Robert B; Nowakowski, John; Marques, Adriana; Johnson, Barbara J B; Dumler, J Stephen

    2013-01-01

    For the diagnosis of Lyme disease, the 2-tier serologic testing protocol for Lyme disease has a number of shortcomings including low sensitivity in early disease; increased cost, time, and labor; and subjectivity in the interpretation of immunoblots. In this study, the diagnostic accuracy of a single-tier commercial C6 ELISA kit was compared with 2-tier testing. The results showed that the C6 ELISA was significantly more sensitive than 2-tier testing with sensitivities of 66.5% (95% confidence interval [CI] 61.7-71.1) and 35.2% (95% CI 30.6-40.1), respectively (P < 0.001) in 403 sera from patients with erythema migrans. The C6 ELISA had sensitivity statistically comparable to 2-tier testing in sera from Lyme disease patients with early neurologic manifestations (88.6% versus 77.3%, P = 0.13) or arthritis (98.3% versus 95.6%, P = 0.38). The specificities of C6 ELISA and 2-tier testing in over 2200 blood donors, patients with other conditions, and Lyme disease vaccine recipients were found to be 98.9% and 99.5%, respectively (P < 0.05, 95% CI surrounding the 0.6 percentage point difference of 0.04 to 1.15). In conclusion, using a reference standard of 2-tier testing, the C6 ELISA as a single-step serodiagnostic test provided increased sensitivity in early Lyme disease with comparable sensitivity in later manifestations of Lyme disease. The C6 ELISA had slightly decreased specificity. Future studies should evaluate the performance of the C6 ELISA compared with 2-tier testing in routine clinical practice.

  7. Single-Tier Testing with the C6 Peptide ELISA Kit Compared with Two-Tier Testing for Lyme Disease

    PubMed Central

    Wormser, Gary P.; Schriefer, Martin; Aguero-Rosenfeld, Maria E.; Levin, Andrew; Steere, Allen C.; Nadelman, Robert B.; Nowakowski, John; Marques, Adriana; Johnson, Barbara J. B.; Dumler, J. Stephen

    2014-01-01

    Background The two-tier serologic testing protocol for Lyme disease has a number of shortcomings including low sensitivity in early disease; increased cost, time and labor; and subjectivity in the interpretation of immunoblots. Methods The diagnostic accuracy of a single-tier commercial C6 ELISA kit was compared with two-tier testing. Results The C6 ELISA was significantly more sensitive than two-tier testing with sensitivities of 66.5% (95% C.I.:61.7-71.1) and 35.2% (95%C.I.:30.6-40.1), respectively (p<0.001) in 403 sera from patients with erythema migrans. The C6 ELISA had sensitivity statistically comparable to two-tier testing in sera from Lyme disease patients with early neurological manifestations (88.6% vs. 77.3%, p=0.13) or arthritis (98.3% vs. 95.6%, p= 0.38). Te specificities of C6 ELISA and two-tier testing in over 2200 blood donors, patients with other conditions, and Lyme disease vaccine recipients were found to be 98.9% and 99.5%, respectively (p<0.05, 95% C.I. surrounding the 0.6 percentage point difference of 0.04 to 1.15). Conclusions Using a reference standard of two-tier testing, the C6 ELISA as a single step serodiagnostic test provided increased sensitivity in early Lyme disease with comparable sensitivity in later manifestations of Lyme disease. The C6 ELISA had slightly decreased specificity. Future studies should evaluate the performance of the C6 ELISA compared with two-tier testing in routine clinical practice. PMID:23062467

  8. Feasibility of a Single Common Powertrain Lubricant-Transmission Bench Testing

    DTIC Science & Technology

    2015-04-01

    the slate of engine oils tested. 15. SUBJECT TERMS Single Common Powertrain Lubricant, SCPL, Transmission, Caterpillar TO-4, Cat TO-4, Dexron...ix ACRONYMS AND ABBREVIATIONS CAT – Caterpillar FRRET – friction retention kPa – kilopascals m/s – meters per second N-m – Newton Meters...on each oil:  Caterpillar TO-4 Friction Test o TO-4 SEQ 1219 (Elastomeric) o TO-4 SEQ 1221 (Steering Brake Paper) o TO-4 SEQ 1222 (Wheel Brake

  9. Testing Landscape Theory for Biomolecular Processes with Single Molecule Fluorescence Spectroscopy

    NASA Astrophysics Data System (ADS)

    Truex, Katherine; Chung, Hoi Sung; Louis, John M.; Eaton, William A.

    2015-07-01

    Although Kramers' theory for diffusive barrier crossing on a 1D free energy profile plays a central role in landscape theory for complex biomolecular processes, it has not yet been rigorously tested by experiment. Here we test this 1D diffusion scenario with single molecule fluorescence measurements of DNA hairpin folding. We find an upper bound of 2.5 μ s for the average transition path time, consistent with the predictions by theory with parameters determined from optical tweezer measurements.

  10. Evaluation of a low-cost transient mass measurement system in vehicle inspection and maintenance testing: results of a Gordon-Darby Study.

    PubMed

    Ensfield, Carl; Gordon, Jay; Lindner, Jim

    2003-09-01

    A study was performed at a Gordon-Darby centralized inspection and maintenance (I/M) test lane in Phoenix, AZ, in December 1999 for the purpose of evaluating the accuracy of production Vehicle Mass Analysis System (VMAS) equipment relative to standard IM240 equipment. Simultaneous transient mass measurements were made on random vehicles using VMAS and IM240 systems on two test lanes during regular I/M testing. Cumulative mass emissions for 846 valid tests were correlated using least-squares regression analysis. Correlation indices were > 0.99 for both carbon monoxide (CO) and nitric oxide (NO) and 0.93 for hydrocarbon (HC), and the standard errors of regression were 1.38 g/mi, 0.123 g/mi, and 0.245 g/mi for CO, NO, and HC, respectively. These strong correlation results are reflected by high excess emission identification rates of 99.4% for CO, 99.3% for NO, and 94.5% for HC when applying final IM240 cut points with a < 2% error of commission for all pollutants.

  11. Statistical searches for microlensing events in large, non-uniformly sampled time-domain surveys: A test using palomar transient factory data

    SciTech Connect

    Price-Whelan, Adrian M.; Agüeros, Marcel A.; Fournier, Amanda P.; Street, Rachel; Ofek, Eran O.; Covey, Kevin R.; Levitan, David; Sesar, Branimir; Laher, Russ R.; Surace, Jason

    2014-01-20

    Many photometric time-domain surveys are driven by specific goals, such as searches for supernovae or transiting exoplanets, which set the cadence with which fields are re-imaged. In the case of the Palomar Transient Factory (PTF), several sub-surveys are conducted in parallel, leading to non-uniform sampling over its ∼20,000 deg{sup 2} footprint. While the median 7.26 deg{sup 2} PTF field has been imaged ∼40 times in the R band, ∼2300 deg{sup 2} have been observed >100 times. We use PTF data to study the trade off between searching for microlensing events in a survey whose footprint is much larger than that of typical microlensing searches, but with far-from-optimal time sampling. To examine the probability that microlensing events can be recovered in these data, we test statistics used on uniformly sampled data to identify variables and transients. We find that the von Neumann ratio performs best for identifying simulated microlensing events in our data. We develop a selection method using this statistic and apply it to data from fields with >10 R-band observations, 1.1 × 10{sup 9} light curves, uncovering three candidate microlensing events. We lack simultaneous, multi-color photometry to confirm these as microlensing events. However, their number is consistent with predictions for the event rate in the PTF footprint over the survey's three years of operations, as estimated from near-field microlensing models. This work can help constrain all-sky event rate predictions and tests microlensing signal recovery in large data sets, which will be useful to future time-domain surveys, such as that planned with the Large Synoptic Survey Telescope.

  12. Depression in Black Single Mothers: A Test of a Theoretical Model.

    PubMed

    Atkins, Rahshida

    2015-06-01

    The aim of this study was to test a theoretical model of depression for Black single mothers. Participants were 208 Black single mothers, aged 18 to 45, recruited from community settings. The a priori over-identified recursive theoretical model was tested via the LISREL 9.1 program using a maximum likelihood estimation for structural equation modeling. The chi-square indicated that there was an excellent fit of the model with the data, χ(2)(1, N = 208) = .05, p = .82. The fit indices for the model were excellent. Path coefficients were statistically significant for seven out of eight of the direct paths within the model (p < .05). The two indirect paths were also statistically significant. The theory was supported and can be applied by health care professionals when working with depressed Black single mothers.

  13. Use of the single-breath method of estimating cardiac output during exercise-stress testing.

    NASA Technical Reports Server (NTRS)

    Buderer, M. C.; Rummel, J. A.; Sawin, C. F.; Mauldin, D. G.

    1973-01-01

    The single-breath cardiac output measurement technique of Kim et al. (1966) has been modified for use in obtaining cardiac output measurements during exercise-stress tests on Apollo astronauts. The modifications involve the use of a respiratory mass spectrometer for data acquisition and a digital computer program for data analysis. The variation of the modified method for triplicate steady-state cardiac output measurements was plus or minus 1 liter/min. The combined physiological and methodological variation seen during a set of three exercise tests on a series of subjects was 1 to 2.5 liter/min. Comparison of the modified method with the direct Fick technique showed that although the single-breath values were consistently low, the scatter of data was small and the correlation between the two methods was high. Possible reasons for the low single-breath cardiac output values are discussed.

  14. Fluid Structure Interaction in a Cold Flow Test and Transient CFD Analysis of Out-of-Round Nozzles

    NASA Technical Reports Server (NTRS)

    Ruf, Joseph; Brown, Andrew; McDaniels, David; Wang, Ten-See

    2010-01-01

    This viewgraph presentation describes two nozzle fluid flow interactions. They include: 1) Cold flow nozzle tests with fluid-structure interaction at nozzle separated flow; and 2) CFD analysis for nozzle flow and side loads of nozzle extensions with various out-of-round cases.

  15. Initial Comparison of Single Cylinder Stirling Engine Computer Model Predictions with Test Results

    NASA Technical Reports Server (NTRS)

    Tew, R. C., Jr.; Thieme, L. G.; Miao, D.

    1979-01-01

    A Stirling engine digital computer model developed at NASA Lewis Research Center was configured to predict the performance of the GPU-3 single-cylinder rhombic drive engine. Revisions to the basic equations and assumptions are discussed. Model predictions with the early results of the Lewis Research Center GPU-3 tests are compared.

  16. The Functioning of Single-Case Randomization Tests with and without Random Assignment.

    ERIC Educational Resources Information Center

    Ferron, John; Foster-Johnson, Lynn; Kromrey, Jeffrey D.

    2003-01-01

    Used Monte Carlo methods to examine the Type I error rates for randomization tests applied to single-case data arising from ABAB designs involving random, systematic, or response-guided assignment of interventions. Discusses conditions under which Type I error rate is controlled or is not. (SLD)

  17. The effectiveness of combined gripping method in tensile testing of UHMWPE single yarn

    NASA Astrophysics Data System (ADS)

    Wang, H. X.; Hazell, P. J.; Shankar, K.; Morozov, E. V.; Escobedo, J. P.

    2015-07-01

    This paper presents the experimental study on the effectiveness of combined gripping method employed in the tensile testing of UHMWPE (Dyneema® SK75) single yarn. Seven different solutions including epoxy, acrylic, and ethyl cyanoacrylate adhesives were tested under quasi-static loadings in order to determine the most effective adhesive for bonding UHMWPE single yarn to aluminium sheets. The ethyl cyanoacrylate adhesive combined with polyolefin surface primer was found to be the best choice which could prevent yarn slippage and ensure the failure of yarn occurs in the gauge section. The single yarns were then tested at three strain rates of 3.3×10-5, 3.3×10-3, and 0.33 s-1. The tensile strength, maximum strain, and Young's modulus were determined from the measured stress-strain curves and compared with the values from literature; the results showed these tensile properties of single yarn depend on strain rate over the range tested.

  18. Transient Effects in Turbulence Modelling.

    DTIC Science & Technology

    1979-12-01

    field data are reported for recirculat- !I " " Ing water flows under steady-state and transient flow conditions in en 0I, Improved 1/15 scale FFTF ...15 scale FFTF outlet plenum test-cell. A dual-channel Laser Doppler Anemometer is used, and a unique method for performing transient measurements is...Description of Loop 26 3.1.2 Repeatable Flow Transient Generator (RFTG) 27 3.1.3 FFTF Test Cell 28 3.2 Laser Doppler Anemometer (LOA) 31 5 3.2.1 General

  19. Single-leg hop testing following fatiguing exercise: reliability and biomechanical analysis.

    PubMed

    Augustsson, J; Thomeé, R; Lindén, C; Folkesson, M; Tranberg, R; Karlsson, J

    2006-04-01

    A fatiguing exercise protocol was combined with single-leg hop testing to improve the possibilities of evaluating the effects of training or rehabilitation interventions. In the first test-retest experiment, 11 healthy male subjects performed two trials of single-leg hops under three different test conditions: non-fatigued and following fatiguing exercise, which consisted of unilateral weight machine knee extensions at 80% and 50%, respectively, of 1 repetition maximum (1 RM) strength. Intraclass correlation coefficients ranged from 0.75 to 0.98 for different hop test conditions, indicating that all tests were reliable. For the second experiment, eight healthy male subjects performed the fatiguing exercise protocol to investigate how fatigue influences lower-extremity joint kinematics and kinetics during single-leg hops. Hip, knee and ankle joint angles, moments and powers, as well as ground-reaction forces were recorded with a six-camera, motion-capture system and a force platform. Recovery of hop performance following the fatiguing exercise was also measured. During the take-off for the single-leg hops, hip and knee flexion angles, generated powers for the knee and ankle joints, and ground-reaction forces decreased for the fatigued hop conditions compared with the non-fatigued condition (P<0.05). Compared with landing during the non-fatigued condition, hip moments and ground-reaction forces were lower for the fatigued hop conditions (P<0.05). The negative joint power was two to three times greater for the knee than for the hip and five to 10 times greater for the knee than for the ankle during landing for all test conditions (P<0.05). Most measured variables had recovered three minutes post-exercise. It is concluded that the fatiguing exercise protocol combined with single-leg hop testing was a reliable method for investigating functional performance under fatigued test conditions. Further, subjects utilized an adapted hop strategy, which employed less hip and

  20. First high gradient test results of a dressed 325 MHz superconducting single spoke resonator at Fermilab

    SciTech Connect

    Webber, R.C.; Khabiboulline, T.; Madrak, R.; Nicol, T.; Ristori, L.; Soyars, W.; Wagner, R.; /Fermilab

    2010-09-01

    A new superconducting RF cavity test facility has been commissioned at Fermilab in conjunction with first tests of a 325 MHz, {beta} = 0.22 superconducting single-spoke cavity dressed with a helium jacket and prototype tuner. The facility is described and results of full gradient, CW cavity tests with a high Q{sub ext} drive coupler are reported. Sensitivities to Q disease and externally applied magnetic fields were investigated. Results are compared to bare cavity results obtained prior to hydrogen degassing and welding into the helium jacket.

  1. Tank selection for Light Duty Utility Arm (LDUA) system hot testing in a single shell tank

    SciTech Connect

    Bhatia, P.K.

    1995-01-31

    The purpose of this report is to recommend a single shell tank in which to hot test the Light Duty Utility Arm (LDUA) for the Tank Waste Remediation System (TWRS) in Fiscal Year 1996. The LDUA is designed to utilize a 12 inch riser. During hot testing, the LDUA will deploy two end effectors (a High Resolution Stereoscopic Video Camera System and a Still/Stereo Photography System mounted on the end of the arm`s tool interface plate). In addition, three other systems (an Overview Video System, an Overview Stereo Video System, and a Topographic Mapping System) will be independently deployed and tested through 4 inch risers.

  2. Characterization of Preferential Flow Paths from Single and Cross-borehole Flowmeter tests in a Fractured Aquifer

    NASA Astrophysics Data System (ADS)

    Bour, O.; Le Borgne, T.; Paillet, F.; Caudal, J.

    2006-12-01

    The structure of the permeability field and in particular the connectivity of preferential flow paths controls the fluxes at large scale as well as the transport properties. However, this information is rarely available in the field unless intensive and time-consuming packer testing is achieved. In this study, we present a characterization of flow paths connectivity at the Plumeur fractured crystalline aquifer from cross-borehole flowmeter tests. We also compare hydraulic properties estimates obtained from single borehole flowmeter experiments, cross borehole flowmeter experiments and long term pumping tests. Cross borehole flowmeter tests have been recently proposed as an efficient technique to characterize the connectivity of fractures between boreholes. Cross borehole flowmeter tests consist of measuring transient vertical flow in an observation borehole when the pumping rate is changed in a nearby pumping well. The rate of change in borehole flow between flow zones intersected by the borehole depends on the connectivity and hydraulic properties of the flow zones between the two boreholes. Flow measurements were achieved with a calibrated heat-pulse flowmeter whose principle is to measure the time for a heat pulse to travel from a heat grid to a thermistor located a few cm above or below the heat source. We combined this method with single borehole flowmeter tests and long-term pumping tests to characterize the connectivity, geometry and hydraulic properties of large scale flow paths at the Plumeur aquifer where long-screened observation boreholes does not allow the use of packers. The aquifer is located on the south coast of Brittany in crystalline bedrock terrain characterized by igneous and metamorphic rocks. We restrict our analysis to the boreholes that are the closest to a pumping station within an area of approximately 600 meters in diameter. These boreholes react relatively rapidly to the pumping variations even for large borehole separations. Most

  3. Finite Element Modeling of Transient Head Field Associated with Partially Penetrating, Slug Tests in a Heterogeneous Aquifer with Low Permeability, Stratigraphic Zones and Faults

    NASA Astrophysics Data System (ADS)

    Cheng, J.; Johnson, B.; Everett, M.

    2003-12-01

    Preliminary field work shows slug interference tests using an array of multilevel active and monitoring wells have potential of permitting enhanced aquifer characterization. Analysis of these test data, however, ultimately will rely on numerical geophysical inverse models. In order to gain insight as well as to provide synthetic data sets, we use a 3-D finite element analysis (code:FEHM-LANL) to explore the effect of idealized, low permeability, stratigraphical and structural (faults) heterogeneities on the transient head field associated with a slug test in a packer-isolated interval of an open borehole. The borehole and packers are modeled explicitly; wellbore storage is selected to match values of field tests. The homogeneous model exhibits excellent agreement with that of the semi-analytical model of Liu and Butler (1995). Models are axisymmetric with a centrally located slugged interval within a homogenous, isotropic, confined aquifer with embedded, horizontal or vertical zones of lower permeability that represent low permeability strata or faults, respectively. Either one or two horizontal layers are located opposite the borehole packers, which is a common situation at the field site; layer thickness (0.15-0.75 m), permeability contrast (up to 4 orders of magnitude contrast) and lateral continuity of layers are varied between models. The effect of a "hole" in a layer also is assessed. Fault models explore effects of thickness (0.05-0.75 m) and permeability contrast as well as additional effects associated with the offset of low permeability strata. Results of models are represented most clearly by contour maps of time of arrival and normalized amplitude of peak head perturbation, but transient head histories at selected locations provide additional insight. Synthesis of the models is on-going but a few points can be made at present. Spatial patterns are distinctive and allow easy discrimination between stratigraphic and structural impedance features. Time

  4. Experimental results of single screw mechanical tests: a follow-up to SAND2005-6036.

    SciTech Connect

    Lee, Sandwook; Lee, Kenneth L.; Korellis, John S.; McFadden, Sam X.

    2006-08-01

    The work reported here was conducted to address issues raised regarding mechanical testing of attachment screws described in SAND2005-6036, as well as to increase the understanding of screw behavior through additional testing. Efforts were made to evaluate fixture modifications and address issues of interest, including: fabrication of 45{sup o} test fixtures, measurement of the frictional load from the angled fixture guide, employment of electromechanical displacement transducers, development of a single-shear test, and study the affect of thread start orientation on single-shear behavior. A286 and 302HQ, No.10-32 socket-head cap screws were tested having orientations with respect to the primary loading axis of 0{sup 0}, 45{sup o}, 60{sup o}, 75{sup o} and 90{sup o} at stroke speeds 0,001 and 10 in/sec. The frictional load resulting from the angled screw fixture guide was insignificant. Load-displacement curves of A286 screws did not show a minimum value in displacement to failure (DTF) for 60{sup o} shear tests. Tests of 302HQ screws did not produce a consistent trend in DTF with load angle. The effect of displacement rate on DTF became larger as shear angle increased for both A286 and 302HQ screws.

  5. Characterization of durable nanostructured thin film catalysts tested under transient conditions using analytical aberration-corrected electron microscopy

    SciTech Connect

    Cullen, David A; More, Karren Leslie; Reeves, Kimberly Shawn; Vernstrom, George; Atanasoska, Liliana; Haugen, Gregory; Atanasoski, Radoslav

    2011-01-01

    The stability of Ru0.1Ir0.9 oxidation evolution reaction (OER) catalysts deposited on Pt-coated nanostructured thin films (NSTFs) has been investigated by aberration-corrected electron microscopy. Accelerated stress tests showed that the OER catalysts significantly improved the durability of the Pt under cell reversal conditions. High-resolution images of the end-of-life NSTFs showed significant Ir loss from the whisker surfaces, while no Pt loss was observed, indicating that the OER catalysts had protected the catalyst coated whisker surfaces from degradation.

  6. Synthesized light transients.

    PubMed

    Wirth, A; Hassan, M Th; Grguras, I; Gagnon, J; Moulet, A; Luu, T T; Pabst, S; Santra, R; Alahmed, Z A; Azzeer, A M; Yakovlev, V S; Pervak, V; Krausz, F; Goulielmakis, E

    2011-10-14

    Manipulation of electron dynamics calls for electromagnetic forces that can be confined to and controlled over sub-femtosecond time intervals. Tailored transients of light fields can provide these forces. We report on the generation of subcycle field transients spanning the infrared, visible, and ultraviolet frequency regimes with a 1.5-octave three-channel optical field synthesizer and their attosecond sampling. To demonstrate applicability, we field-ionized krypton atoms within a single wave crest and launched a valence-shell electron wavepacket with a well-defined initial phase. Half-cycle field excitation and attosecond probing revealed fine details of atomic-scale electron motion, such as the instantaneous rate of tunneling, the initial charge distribution of a valence-shell wavepacket, the attosecond dynamic shift (instantaneous ac Stark shift) of its energy levels, and its few-femtosecond coherent oscillations.

  7. Cost-Effectiveness between Double and Single Fecal Immunochemical Test(s) in a Mass Colorectal Cancer Screening

    PubMed Central

    Cai, Shan-Rong; Zhu, Hong-Hong; Huang, Yan-Qin; Li, Qi-Long; Ma, Xin-Yuan; Zhang, Su-Zhan; Zheng, Shu

    2016-01-01

    This study investigated the cost-effectiveness between double and single Fecal Immunochemical Test(s) (FIT) in a mass CRC screening. A two-stage sequential screening was conducted. FIT was used as a primary screening test and recommended twice by an interval of one week at the first screening stage. We defined the first-time FIT as FIT1 and the second-time FIT as FIT2. If either FIT1 or FIT2 was positive (+), then a colonoscopy was recommended at the second stage. Costs were recorded and analyzed. A total of 24,419 participants completed either FIT1 or FIT2. The detection rate of advanced neoplasm was 19.2% among both FIT1+ and FIT2+, especially high among men with age ≥55 (27.4%). About 15.4% CRC, 18.9% advanced neoplasm, and 29.9% adenoma missed by FIT1 were detected by FIT2 alone. Average cost was $2,935 for double FITs and $2,121 for FIT1 to detect each CRC and $901 for double FITs and $680 for FIT1 to detect each advanced neoplasm. Double FITs are overall more cost-effective, having significantly higher positive and detection rates with an acceptable higher cost, than single FIT. Double FITs should be encouraged for the first screening in a mass CRC screening, especially in economically and medically underserved populations/areas/countries. PMID:27144171

  8. Tracer Tests in a Fractured Dolomite: 3. Analysis of Mass Transfer in Single-Well Injection-Withdrawal Tests

    SciTech Connect

    Haggerty, R.; Fleming, S.W.; Meigs, L.C.; McKenna, S.A.

    1999-03-04

    We investigated multiple-rate diffusion as a possible explanation for observed behavior in a suite of single-well injection-withdrawal (SWIW) tests conducted in a fractured dolomite. We first investigated the ability of a conventional double-porosity model and a multirate diffusion model to explain the data. This revealed that the multirate diffusion hypothesis/model is most consistent with all available data, and is the only model to date that is capable of matching each of the recovery curves entirely. Second, we studied the sensitivity of the SWIW recovery curves to the distribution of diffusion rate coefficients and other parameters. We concluded that the SWIW test is very sensitive to the distribution of rate coefficients, but is relatively insensitive to other flow and transport parameters such as advective porosity and dispersivity. Third, we examined the significance of the constant double-log late-time slopes ({minus}2. 1 to {minus}2.8), which are present in several data sets. The observed late-time slopes are significantly different than would be predicted by either conventional double-porosity or single-porosity media, and are found to be a distinctive feature of multirate diffusion under SWIW test conditions. Fourth, we found that the estimated distributions of diffusion rate coefficients are very broad, with the distributions spanning a range of at least 3.6 to 5.7 orders of magnitude.

  9. High-pressure hydrogen testing of single crystal superalloys for advanced rocket engine turbopump turbine blades

    NASA Technical Reports Server (NTRS)

    Parr, R. A.; Alter, W. S.; Johnston, M. H.; Strizak, J. P.

    1985-01-01

    A screening program to determine the effects of high pressure hydrogen on selected candidate materials for advanced single crystal turbine blade applications is examined. The alloys chosen for the investigation are CM SX-2, CM SX-4C, Rene N-4, and PWA1480. Testing is carried out in hydrogen and helium at 34 MPa and room temperature, with both notched and unnotched single crystal specimens. Results show a significant variation in susceptibility to Hydrogen Environment Embrittlement (HEE) among the four alloys and a marked difference in fracture topography between hydrogen and helium environment specimens.

  10. High-pressure hydrogen testing of single crystal superalloys for advanced rocket engine turbopump turbine blades

    NASA Technical Reports Server (NTRS)

    Alter, W. S.; Parr, R. A.; Johnston, M. H.; Strizak, J. P.

    1984-01-01

    A screening program to determine the effects of high pressure hydrogen on selected candidate materials for advanced single crystal turbine blade applications is examined. The alloys chosen for the investigation are CM SX-2, CM SX-4C, Rene N-4, and PWA1480. Testing is carried out in hydrogen and helium at 34 MPa and room temperature, with both notched and unnotched single crystal specimens. Results show a significant variation in susceptibility to Hydrogen Environment Embrittlement (HEE) among the four alloys and a marked difference in fracture topography between hydrogen and helium environment specimens.

  11. Testing a new automated single ring infiltrometer for Beerkan infiltration experiments

    NASA Astrophysics Data System (ADS)

    Di Prima, Simone; Lassabatère, Laurent; Angulo-Jaramillo, Rafael; Bagarello, Vincenzo; Iovino, Massimo

    2015-04-01

    algorithms according to numerical results. In these cases, the failures are due to the fact that steady state is not properly reached or the transient state is not properly described (not enough points in the transient state). Finally, the infiltrometer was tested in different soil types. All experiments were carried in an infiltration basin located in the pumping well filed of Crépieux-Charmy, which provides drinking water for the Lyon metropolitan area. Water infiltration experiments were conducted on the subsoil, the layer of sand embedded at surface, either clean or clogged. Experiments and analysis with BEST algorithms proved efficient to pinpoint the decrease in hydraulic conductivity due to clogging. The experiments showed that the automatic data collection increases measurement speeds and allows for more efficient data handling and analysis.

  12. Screening of nanosatellite microprocessors using californium single-event latch-up test results

    NASA Astrophysics Data System (ADS)

    Tomioka, Takahiro; Okumura, Yuta; Masui, Hirokazu; Takamiya, Koichi; Cho, Mengu

    2016-09-01

    A single-event latch-up (SEL) test using a 252Cf radioisotope was carried out. The results were compared with those of a proton test and from observation in orbit. A radioisotope can reproduce phenomena observed in orbit that are caused by protons. Considering the inexpensive nature of the 252Cf test, it is more suitable for nanosatellites that require low cost and fast delivery. A SEL occurrence rate of a commercial-off-the-shelf microprocessor was derived from the ground test results. The 252Cf test provided a SEL rate approximately 1×106 times greater than that in orbit. This data can be used to derive the minimum SEL occurrence rate in orbit and help satellite designers to evaluate the risk of SEL and take measures if necessary.

  13. Four applications of permutation methods to testing a single-mediator model.

    PubMed

    Taylor, Aaron B; MacKinnon, David P

    2012-09-01

    Four applications of permutation tests to the single-mediator model are described and evaluated in this study. Permutation tests work by rearranging data in many possible ways in order to estimate the sampling distribution for the test statistic. The four applications to mediation evaluated here are the permutation test of ab, the permutation joint significance test, and the noniterative and iterative permutation confidence intervals for ab. A Monte Carlo simulation study was used to compare these four tests with the four best available tests for mediation found in previous research: the joint significance test, the distribution of the product test, and the percentile and bias-corrected bootstrap tests. We compared the different methods on Type I error, power, and confidence interval coverage. The noniterative permutation confidence interval for ab was the best performer among the new methods. It successfully controlled Type I error, had power nearly as good as the most powerful existing methods, and had better coverage than any existing method. The iterative permutation confidence interval for ab had lower power than do some existing methods, but it performed better than any other method in terms of coverage. The permutation confidence interval methods are recommended when estimating a confidence interval is a primary concern. SPSS and SAS macros that estimate these confidence intervals are provided.

  14. Transient effect of single dose exposure of Nigerian Bonny-light crude oil on testicular steroidogenesis in Wistar rats is accompanied by oxidative stress.

    PubMed

    Ebokaiwe, Azubuike Peter; Ramesh, Parjapath; Mathur, Premendu Prakash; Farombi, Ebenezer Olatunde

    2015-10-01

    The folkloric use of Nigerian Bonny-light crude oil (BLCO) in Niger Delta area of Nigeria is a common practice. There is increasing experimental evidence portending the adverse effects of BLCO an environmental toxicant on testicular function. We investigated the effects of single dose of BLCO (800 mg/kg body weight) on the activities of steroidogenic and antioxidant enzymes such as serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone, 3 β-hydroxy-steroid dehydrogenase (3 β-HSD), 17 β-hydroxy-steroid dehydrogenase (17 β-HSD), superoxide dismutase (SOD), glutathione-S-transferase (GST) and glutathione peroxidase (GSH-Px), levels of lipid peroxidation (LPO), glutathione reduced (GSH) and steroidogenic acute regulatory (StAR) protein, in testes of rats. There was a sequential reduction in the concentration of steroid hormones and activities of steroidogenic enzymes with a concomitant decrease in levels of StAR protein, followed by a parallel increase in antioxidant enzyme activities and levels of LPO. These findings revealed inhibitory effects of BLCO on testicular steroidogenesis and the possible role of oxidative stress in testicular dysfunction observed in this study.

  15. Exploring the efficacy of paternity and kinship testing based on single nucleotide polymorphisms.

    PubMed

    Mo, Shao-Kang; Liu, Ya-Cheng; Wang, Sheng-qi; Bo, Xiao-Chen; Li, Zhen; Chen, Ying; Ni, Ming

    2016-05-01

    Short tandem repeats (STRs) are conventional genetic markers typically used for paternity and kinship testing. As supplementary markers of STRs, single nucleotide polymorphisms (SNPs) have less discrimination power but broader applicability to degraded samples. The rapid improvement of next-generation sequencing (NGS) and multiplex amplification technologies also make it possible now to simultaneously identify dozens or even hundreds of SNP loci in a single pool. However, few studies have been endeavored to kinship testing based on SNP loci. In this study, we genotyped 90 autosomal human identity SNP loci with NGS, and investigated their testing efficacies based on the likelihood ratio model in eight pedigree scenarios involving paternity, half/full-sibling, uncle/nephew, and first-cousin relationships. We found that these SNPs might be sufficient to discriminate paternity and full-sibling, but impractical for more distant relatives such as uncle and cousin. Furthermore, we conducted an in silico study to obtain the theoretical tendency of how testing efficacy varied with increasing number of SNP loci. For each testing battery in a given pedigree scenario, we obtained distributions of logarithmic likelihood ratio for both simulated relatives and unrelated controls. The proportion of the overlapping area between the two distributions was defined as a false testing level (FTL) to evaluate the testing efficacy. We estimated that 85, 127, 491, and 1,858 putative SNP loci were required to discriminate paternity, full-sibling, half-sibling/uncle-nephew, and first-cousin (FTL, 0.1%), respectively. To test a half-sibling or nephew, an additional uncle relative could be included to decrease the required number of putative SNP loci to ∼320 (FTL, 0.1%). As a systematic computation of paternity and kinship testing based only on SNPs, our results could be informative for further studies and applications on paternity and kinship testing using SNP loci.

  16. Transient Pulse Monitor

    DTIC Science & Technology

    1988-05-20

    connection to the test solar array pannels . One radiated electromagnetic signal sensor will be placed on one of the solar array panels (Figures 6 and 7). The...22 02 Spacecraft, Charging , Discharge, Transient, Environment 19. ABSTRACT (Cmntnue on mromN ifesor AWMI endwtfr by blok numfber) SRI International is...6 2.1.2 Particle Interactions with Satellite Materials: Charging ........................ 6 2.1.3 Discharges and Their Effects on Systems

  17. Prolonged, but transient, elevation of liver and biliary function tests in a healthy infant affected with breast milk jaundice.

    PubMed

    Poddighe, Dimitri; Castelli, Lucia; Marseglia, Gian Luigi; Bruni, Paola

    2014-05-28

    Unconjugated hyperbilirubinaemia is a common finding in newborns. When it is exaggerated, it is usually investigated in order to exclude several diseases, such as newborn's haemolytic diseases, infections or hypothyroidism. Breast milk jaundice is a form of neonatal jaundice related to breast feeding and it is not usually associated with any clinical issue and/or other laboratory abnormalities. We describe a case of breast milk jaundice being associated, unexpectedly, to significant elevation of plasmatic liver and biliary enzymes. Despite the infant's good clinical condition and growth, several investigations were performed and these ruled out metabolic, infectious and autoimmune liver diseases. All liver function tests normalised by 6-7 months of life. We suggest that the finding of hypertransaminasaemia and hyper-γ-glutamyl transpeptidase in a benign clinical context (similar to what we described) should be followed for 6-7 months before performing sophisticated and expensive diagnostic investigations which aim at excluding some unlikely and severe diseases in a completely asymptomatic infant.

  18. Performance of Enhanced Liver Fibrosis test and comparison with transient elastography in the identification of liver fibrosis in patients with chronic hepatitis B infection.

    PubMed

    Trembling, P M; Lampertico, P; Parkes, J; Tanwar, S; Viganò, M; Facchetti, F; Colombo, M; Rosenberg, W M

    2014-06-01

    Assessment of liver fibrosis is important in determining prognosis, disease progression and need for treatment in patients with chronic hepatitis B (CHB). Limitations to the use of liver biopsy in assessing fibrosis are well recognized, and noninvasive tests are being increasingly evaluated including transient elastography (TE) and serum markers such as the Enhanced Liver Fibrosis (ELF) test. We assessed performance of ELF and TE in detecting liver fibrosis with reference to liver histology in a cohort of patients with CHB (n = 182), and compared the performance of these modalities. Median age was 46 and mean AST 70 IU/L. Cirrhosis was reported in 20% of liver biopsies. Both modalities performed well in assessing fibrosis at all stages. Area under receiver operator characteristic (AUROC) curves for detecting METAVIR fibrosis stages F ≥ 1, F ≥ 2, F ≥ 3 and F4 were 0.77, 0.82, 0.80 and 0.83 for ELF and 0.86, 0.86, 0.90 and 0.95 for TE. TE performed significantly better in the assessment of severe fibrosis (AUROC 0.80 for ELF and 0.90 for TE, P < 0.01) and cirrhosis (0.83 for ELF and 0.95 for TE, P < 0.01). This study demonstrates that ELF has good performance in detection of liver fibrosis in patients with CHB, and when compared, TE performs better in detection of severe fibrosis/cirrhosis.

  19. RELAP5/MOD3 Analysis of Transient Steam-Generator Behavior During Turbine Trip Test of a Prototype Fast Breeder Reactor MONJU

    SciTech Connect

    Yoshihisa Shindo; Hiroshi Endo; Tomoko Ishizu; Kazuo Haga

    2006-07-01

    In order to develop a thermal-hydraulic model of the steam-generator (SG) to simulate transient phenomena in the sodium cooled fast breeder reactor (FBR) MONJU, Japan Nuclear Energy Safety Organization (JNES) verified the SG model using the RELAP5/MOD3 code against the results of the turbine trip test at a 40% power load of MONJU. The modeling by using RELAP5 was considered to explain the significant observed behaviors of the pressure and the temperature of the EV steam outlet, and the temperature of water supply distributing piping till 600 seconds after the turbine trip. The analysis results of these behaviors showed good agreement with the test results based on results of parameter study as the blow efficiency (release coef.) and heat transferred from the helical coil region to the down-comer (temperature heating down-comer tubes). It was found that the RELAP5/MOD3 code with a two-fluids model can predict well the physical situation: the gas-phase of steam generated by the decompression boiling moves upward in the down-comer tubes accompanied by the enthalpy increase of the water supply chambers; and that the pressure change of a 'shoulder' like shape is induced by the mass balance between the steam mass generated in the down-comer tubes and the steam mass blown from the SG. The applicability of RELAP5/MOD3 to SG modeling was confirmed by simulating the actual FBR system. (authors)

  20. Performance of Enhanced Liver Fibrosis test and comparison with transient elastography in the identification of liver fibrosis in patients with chronic hepatitis B infection

    PubMed Central

    Trembling, P M; Lampertico, P; Parkes, J; Tanwar, S; Viganò, M; Facchetti, F; Colombo, M; Rosenberg, W M

    2014-01-01

    Assessment of liver fibrosis is important in determining prognosis, disease progression and need for treatment in patients with chronic hepatitis B (CHB). Limitations to the use of liver biopsy in assessing fibrosis are well recognized, and noninvasive tests are being increasingly evaluated including transient elastography (TE) and serum markers such as the Enhanced Liver Fibrosis (ELF) test. We assessed performance of ELF and TE in detecting liver fibrosis with reference to liver histology in a cohort of patients with CHB (n = 182), and compared the performance of these modalities. Median age was 46 and mean AST 70 IU/L. Cirrhosis was reported in 20% of liver biopsies. Both modalities performed well in assessing fibrosis at all stages. Area under receiver operator characteristic (AUROC) curves for detecting METAVIR fibrosis stages F ≥ 1, F ≥ 2, F ≥ 3 and F4 were 0.77, 0.82, 0.80 and 0.83 for ELF and 0.86, 0.86, 0.90 and 0.95 for TE. TE performed significantly better in the assessment of severe fibrosis (AUROC 0.80 for ELF and 0.90 for TE, P < 0.01) and cirrhosis (0.83 for ELF and 0.95 for TE, P < 0.01). This study demonstrates that ELF has good performance in detection of liver fibrosis in patients with CHB, and when compared, TE performs better in detection of severe fibrosis/cirrhosis. PMID:24750297

  1. The MWA Transients Survey (MWATS).

    NASA Astrophysics Data System (ADS)

    Bell, M.; Murphy, T.; Kaplan, D. L.; Croft, S. D.; Hancock, P.; Rowlinson, A.; Wayth, R.; Gaensler, B.; Hurley-Walker, N.; Offringa, A.; Loi, C.; Bannister, K.; Trott, C.; Marquart, J.

    2017-01-01

    We propose the continuation of the MWA transients survey to search for and monitor low frequency transient and variable radio sources in the southern sky. This proposal is aimed at commensally utilising data from the GLEAM-X (G0008) project in semester 2017-A. The aim of this commensal data acquisition is to commission long baseline observations for transient science. In particular this will involve studying the impact of the ionosphere on calibration and imaging, and developing the techniques needed to produce science quality data products. The proposed drift scans with LST locking (see G0008 proposal) are particularly exciting as we can test image subtraction for transient and variable identification. This survey is targeted at studying objects such as AGN (intrinsic and extrinsic variability), long duration synchrotron emitters, pulsars and transients of unknown origin. The maps generated from this survey will be analysed with the Variables and Slow Transients (VAST) detection pipeline. The motivation for this survey is as follows: (i) To obtain temporal data on an extremely large and robust sample of low frequency sources to explore and quantify both intrinsic and extrinsic variability; (ii) To search and find new classes of low frequency radio transients that previously remained undetected and obscured from multi-wavelength discovery; (iii) To place rigorous statistics on the occurrence of both transients and variables prior to the Australian SKA era.

  2. Pollution emissions from single swirl-can combustor modules at parametric test conditions

    NASA Technical Reports Server (NTRS)

    Mularz, E. J.; Wear, J. D.; Verbulecz, P. W.

    1975-01-01

    Exhaust pollutant emissions were measured from single swirl-can combustor modules operating over a pressure range of 69 to 276 N/sq cm (100 to 400 psia), over a fuel-air ratio range of 0.01 to 0.04, at an inlet air temperature of 733 K (860 F), and at a constant reference velocity of 23.2 m/sec). Many swirl-can module designs were evaluated; the 11 most promising designs exhibited oxides of nitrogen emission levels lower than that from conventional gas-turbine combustors. Although these single module test results are not necessarily indicative of the performance characteristics of a large array of modules, the results are very promixing and offer a number of module designs that should be tested in a full combustor.

  3. Interpretation of transmissivity estimates from single-well pumping aquifer tests

    USGS Publications Warehouse

    Halford, K.J.; Weight, W.D.; Schreiber, R.P.

    2006-01-01

    Interpretation of single-well tests with the Cooper-Jacob method remains more reasonable than most alternatives. Drawdowns from 628 simulated single-well tests where transmissivity was specified were interpreted with the Cooper-Jacob straight-line method to estimate transmissivity. Error and bias as a function of vertical anisotropy, partial penetration, specific yield, and interpretive technique were investigated for transmissivities that ranged from 10 to 10,000 m2/d. Cooper-Jacob transmissivity estimates in confined aquifers were affected minimally by partial penetration, vertical anisotropy, or analyst. Cooper-Jacob transmissivity estimates of simulated unconfined aquifers averaged twice the known values. Transmissivity estimates of unconfined aquifers were not improved by interpreting results with an unconfined aquifer solution. Judicious interpretation of late-time data consistently improved estimates where transmissivity exceeded 250 m2/d in unconfined aquifers. ?? 2006 National Ground Water Association.

  4. High-Gradient Tests of the Single-Cell SC Cavity with a Feedback Waveguide

    SciTech Connect

    Yakovlev, V.; Solyak, N.; Wu, G.; Ge, M.; Gonin, I.; Khabiboulline, T.; Ozelis, J.; Rowe, A.; Avrakhov, P.; Kanareykin, A.; Rathke, J.

    2010-11-04

    Use of a superconducting (SC) traveling-wave accelerating (STWA) structure with a small phase advance per cell, rather than a standing-wave structure, may provide a significant increase in the accelerating gradient in the ILC linac [1]. For the same surface electric and magnetic fields, the STWA achieves an accelerating gradient 1.2 larger than TESLA-like standing-wave cavities. In addition, the STWA allows longer acceleration cavities, reducing the number of gaps between them. However, the STWA structure requires a SC feedback waveguide to return the few hundreds of MW of circulating RF power from the structure output to the structure input. A test single-cell cavity with feedback was designed and manufactured to demonstrate the possibility of proper processing to achieve a high accelerating gradient. The first results of high-gradient tests of a prototype 1.3 GHz single-cell cavity with feedback waveguide will be presented.

  5. The single category implicit association test as a measure of implicit social cognition.

    PubMed

    Karpinski, Andrew; Steinman, Ross B

    2006-07-01

    The Single Category Implicit Association Test (SC-IAT) is a modification of the Implicit Association Test that measures the strength of evaluative associations with a single attitude object. Across 3 different attitude domains--soda brand preferences, self-esteem, and racial attitudes--the authors found evidence that the SC-IAT is internally consistent and makes unique contributions in the ability to understand implicit social cognition. In a 4th study, the authors investigated the susceptibility of the SC-IAT to faking or self-presentational concerns. Once participants with high error rates were removed, no significant self-presentation effect was observed. These results provide initial evidence for the reliability and validity of the SC-IAT as an individual difference measure of implicit social cognition.

  6. Impact of typical steady-state conditions and transient conditions on flow ripple and its test accuracy for axial piston pump

    NASA Astrophysics Data System (ADS)

    Xu, Bing; Hu, Min; Zhang, Junhui

    2015-09-01

    The current research about the flow ripple of axial piston pump mainly focuses on the effect of the structure of parts on the flow ripple. Therein, the structure of parts are usually designed and optimized at rated working conditions. However, the pump usually has to work in large-scale and time-variant working conditions. Therefore, the flow ripple characteristics of pump and analysis for its test accuracy with respect to variant steady-state conditions and transient conditions in a wide range of operating parameters are focused in this paper. First, a simulation model has been constructed, which takes the kinematics of oil film within friction pairs into account for higher accuracy. Afterwards, a test bed which adopts Secondary Source Method is built to verify the model. The simulation and tests results show that the angular position of the piston, corresponding to the position where the peak flow ripple is produced, varies with the different pressure. The pulsating amplitude and pulsation rate of flow ripple increase with the rise of pressure and the variation rate of pressure. For the pump working at a constant speed, the flow pulsation rate decreases dramatically with the increasing speed when the speed is less than 27.78% of the maximum speed, subsequently presents a small decrease tendency with the speed further increasing. With the rise of the variation rate of speed, the pulsating amplitude and pulsation rate of flow ripple increase. As the swash plate angle augments, the pulsating amplitude of flow ripple increases, nevertheless the flow pulsation rate decreases. In contrast with the effect of the variation of pressure, the test accuracy of flow ripple is more sensitive to the variation of speed. It makes the test accuracy above 96.20% available for the pulsating amplitude of pressure deviating within a range of ±6% from the mean pressure. However, with a variation of speed deviating within a range of ±2% from the mean speed, the attainable test

  7. Single well surfactant test to evaluate surfactant floods using multi tracer method

    DOEpatents

    Sheely, Clyde Q.

    1979-01-01

    Data useful for evaluating the effectiveness of or designing an enhanced recovery process said process involving mobilizing and moving hydrocarbons through a hydrocarbon bearing subterranean formation from an injection well to a production well by injecting a mobilizing fluid into the injection well, comprising (a) determining hydrocarbon saturation in a volume in the formation near a well bore penetrating formation, (b) injecting sufficient mobilizing fluid to mobilize and move hydrocarbons from a volume in the formation near the well bore, and (c) determining the hydrocarbon saturation in a volume including at least a part of the volume of (b) by an improved single well surfactant method comprising injecting 2 or more slugs of water containing the primary tracer separated by water slugs containing no primary tracer. Alternatively, the plurality of ester tracers can be injected in a single slug said tracers penetrating varying distances into the formation wherein the esters have different partition coefficients and essentially equal reaction times. The single well tracer method employed is disclosed in U.S. Pat. No. 3,623,842. This method designated the single well surfactant test (SWST) is useful for evaluating the effect of surfactant floods, polymer floods, carbon dioxide floods, micellar floods, caustic floods and the like in subterranean formations in much less time and at much reduced cost compared to conventional multiwell pilot tests.

  8. Proton Single Event Effects (SEE) Testing of the Myrinet Crossbar Switch and Network Interface Card

    NASA Technical Reports Server (NTRS)

    Howard, James W., Jr.; LaBel, Kenneth A.; Carts, Martin A.; Stattel, Ronald; Irwin, Timothy L.; Day, John H. (Technical Monitor)

    2002-01-01

    As part of the Remote Exploration and Experimentation Project (REE), work was performed to do a proton SEE (Single Event Effect) evaluation of the Myricom network protocol system (Myrinet). This testing included the evaluation of the Myrinet crossbar switch and the Network Interface Card (NIC). To this end, two crossbar switch devices and five components in the NIC were exposed to the proton beam at the University of California at Davis Crocker Nuclear Laboratory (CNL).

  9. High performance N204/amine elements: Blowapart. [test, and analysis of single element injectors

    NASA Technical Reports Server (NTRS)

    Lawver, B. R.

    1974-01-01

    The work is reported which was conducted to define the mechanisms governing blowapart of hypergolic propellant through the design, fabrication, test, and analysis of single element injectors. Data were developed that show the parameters exhibiting a controlling influence over blowapart are the chamber pressure, orifice diameter, and propellant temperature. Mixing, popping (cyclic blowapart), low pressure separation, and high pressure separation were identified as modes of reactive impingement.

  10. Novel Application of Single-Well Tracer Tests to Evaluate Hydraulic Stimulation Effectiveness

    SciTech Connect

    G. M. Shook; Gopi Nalla

    2005-09-01

    This paper presents a graphical method by which one can identify the number of fractures and their permeability distribution in the near-well region from single-well tracer tests. The method is an extension of tracer analysis methods developed previously to estimate flow geometry and relies on caluclating the relative fluid velocity from F-__ plots. A number of numerical examples show that high flow zones (fractures) are readily identified from the derivatives of an F-___ curve. The method can be used in evaluating well stimulation efforts by conducting a tracer test before and after the stimulation and comparing the velocity distributions.

  11. High gradient test of the HINS SSR1 single spoke resonator

    SciTech Connect

    Gonin, I.; Khabibouline, T.; Lanfranco, G.; Mukherjee, A.; Ozelis, JH.; Ristori, L.; Sergatskov, A.; Wagner, R.; Webber, R.; /Fermilab

    2008-09-01

    Eighteen {beta} = 0.21 superconducting single spoke resonators comprise the first state in the cold section of the 8-GeV H{sup -} Linac for Fermilab's proposed Project X. After Buffered Chemical Polishing and High Pressure Rinse, one resonator has undergone high gradient RF testing at 2.0-4.5 K in the Vertical Test Stand at Fermilab. They present measurements of the surface resistance as a function of temperature and the quality factor as a function of accelerating field. The resonator reached an accelerating field of 18.0 MV/m.

  12. Testing of plain and fibrous concrete single cavity prestressed concrete reactor vessel models

    SciTech Connect

    Oland, C.B.

    1985-01-01

    Two single-cavity prestressed concrete reactor vessel (PCRV) models were fabricated and tested to failure to demonstrate the structural response and ultimate pressure capacity of models cast from high-strength concretes. Concretes with design compressive strengths in excess of 70 MPa (10,000 psi) were developed for this investigation. One model was cast from plain concrete and failed in shear at the head region. The second model was cast from fiber reinforced concrete and failed by rupturing the circumferential prestressing at the sidewall of the structure. The tests also demonstrated the capabilities of the liner system to maintain a leak-tight pressure boundary. 3 refs., 4 figs.

  13. Feasibility of loophole-free nonlocality tests with a single photon

    SciTech Connect

    Chaves, Rafael; Brask, Jonatan Bohr

    2011-12-15

    Recently, much interest has been directed toward designing setups that achieve realistic loss thresholds for decisive tests of local realism--in particular in the optical regime. We analyze the feasibility of such Bell tests based on a W state shared between multiple parties, which can be realized, for example, by a single photon shared between spatial modes. We develop a general error model to obtain thresholds for the efficiencies required to violate local realism and also consider two concrete optical-measurement schemes.

  14. Advanced development of the Spectrum Sciences Model 5005-TF, single event test fixture

    NASA Astrophysics Data System (ADS)

    Ackermann, M. R.; Browning, J. S.; Hughlock, B. W.; Lum, G. K.; Tsacoyeanes, W. C.; Weeks, M. D.

    A commercial application of particle identification methods commonly used in high-energy physics research has been developed for single-event testing of microelectronics. The Model 5005-TF single event test fixture can be used to substantially reduce the parts qualification testing costs for many space satellite systems. The 5005-TF includes a californium source, photomultiplier tubes, ultra thin film scintillation detectors, mountings, a vacuum chamber and related controls, and electronics for processing time-of-flight (TOF) signals. Tests were conducted to examine how well the TOF parameter identified the fission fragment (atomic number, mass, kinetic energy). For the lighter fragments, the TOF parameter has a maximum error of about 30 atomic mass units, which is inadequate for particle identification. Since light output of thin-film scintillators was known to correlate with average velocity of a fission fragment passing through the scintillator, it was decided to use the light output in conjunction with TOF to improve particle identification. This dual-parameter method was implemented in the 5005-TF and test results show favorable comparison with results from an ion beam facility.

  15. Study of the comminution characteristics of coal by single particle breakage test device

    SciTech Connect

    Sahoo, R.

    2005-09-01

    Single-particle breakage tests of South Blackwater and Ensham coal from the Bowen Basin area in Queensland were conducted by a computer-monitored twin-pendulum device to measure the energy utilization pattern of the breakage particles. Three particle sizes (-16.0+13.2mm, -13.2+11.2mm, -11.2+9.5mm) of each coal were tested by a pendulum device at five input energy levels to measure the specific comminution energy. When particles were tested at constant input energy, the variation of comminution energy between the same size broken particles of Ensham coal was minimal, because Ensham coal is a softer and higher friability coal, which absorbs more input energy than harder coal during breakage tests. For different particle sizes, the specific comminution energy increases linearly with the input energy and the fineness of the breakage products increases with the specific comminution energy. The size distribution graphs are curved but approach linearity in the finer region. At a constant input energy, the twin pendulum breakage product results show that the fineness of the products increases with decrease in particle size and South Blackwater coal produced finer products than the Ensham coal. The t-curves are the family of size distribution curves, which can describe the product size distribution of the breakage particles during single-particle breakage tests.

  16. Fabrication and Testing of Full-Length Single-Cell Externally Fueled Converters for Thermionic Reactors

    SciTech Connect

    Schock, Alfred

    1994-06-01

    The preceding paper described designs and analyses of thermionic reactors employing full-core-length single-cell converters with their heated emitters located on the outside of their internally cooled collectors, and it presented results of detailed parametric analyses which illustrate the benefits of this unconventional design. The present paper describes the fabrication and testing of full-length prototypical converters, both unfueled and fueled, and presents parametric results of electrically heated tests. The unfueled converter tests demonstrated the practicality of operating such long converters without shorting across a 0.3-mm interelectrode gap. They produced a measured peak output of 751 watts(e) from a single diode and a peak efficiency of 15.4%. The fueled converter tests measured the parametric performance of prototypic UO(subscript 2)-fueled converters designed for subsequent in-pile testing. They employed revolver-shaped tungsten elements with a central emitter hole surrounded by six fuel chambers. The full-length converters were heated by a water-cooled RF-induction coil inside an ion-pumped vacuum chamber. This required development of high-vacuum coaxial RF feedthroughs. In-pile test rules required multiple containment of the UO (subscript 2)-fuel, which complicated the fabrication of the test article and required successful development of techniques for welding tungsten and other refractory components. The test measured a peak power output of 530 watts(e) or 7.1 watts/cm (superscript 2) at an efficiency of 11.5%. There are three copies in the file. Cross-Reference a copy FSC-ESD-217-94-529 in the ESD files with a CID #8574.

  17. A numerical comparison with an exact solution for the transient response of a cylinder immersed in a fluid. [computer simulated underwater tests to determine transient response of a submerged cylindrical shell

    NASA Technical Reports Server (NTRS)

    Giltrud, M. E.; Lucas, D. S.

    1979-01-01

    The transient response of an elastic cylindrical shell immersed in an acoustic media that is engulfed by a plane wave is determined numerically. The method applies to the USA-STAGS code which utilizes the finite element method for the structural analysis and the doubly asymptotic approximation for the fluid-structure interaction. The calculations are compared to an exact analysis for two separate loading cases: a plane step wave and an exponentially decaying plane wave.

  18. Reducing carbonyl emissions from a heavy-duty diesel engine at US transient cycle test by use of paraffinic/biodiesel blends

    NASA Astrophysics Data System (ADS)

    Yuan, Chung-Shin; Lin, Yuan-Chung; Tsai, Cheng-Hsien; Wu, Chia-Chieh; Lin, Yu-Sheng

    2009-12-01

    Formaldehyde and acetaldehyde are toxic carcinogens so their reductions in diesel-engine emissions are desirable. This study investigated emissions of carbonyl compounds (CBCs) from an HDDE (heavy-duty diesel engine) at US transient cycle test, using five test fuels: premium diesel fuel (D100), P100 (100% palm-biodiesel), P20 (20% palm-biodiesel + 80% premium diesel fuel), PF80P20 (80% paraffinic fuel + 20% palm-biodiesel), and PF95P05 (95% paraffinic fuel + 5% palm-biodiesel). Experimental results indicate that formaldehyde was the major carbonyl in the exhaust, accounting for 70.1-76.2% of total CBC concentrations for all test fuels. In comparison with D100 (172 mg BHP -1 h -1), the reductions of formaldehyde and acetaldehyde emission factor for P100, P20, PF80P20, and PF95P05 were (-16.8%, -61.8%), (-10.0%, -39.0%), (21.3%, 1.10%), and (31.1%, 19.5%), respectively. Using P100 and P20 instead of D100 in the HDDE increased CBC concentrations by 14.5% and 3.28%, respectively, but using PF80P20 and PF95P05 significantly reduced CBC concentrations by 30.3% and 23.7%, respectively. Using P100 and P20 instead of D100 (2867 ton yr -1) in the HDDE increased CBC emissions by 240 and 224 ton yr -1, respectively, but using PF80P20, and PF95P05 instead of D100 in the HDDE decreased CBC emissions by 711 and 899 ton yr -1, respectively. The above results indicate that the wide usage of paraffinic-palmbiodiesel blends as alternative fuels could protect the environment.

  19. Transient modeling and parameter identification based on wavelet and correlation filtering for rotating machine fault diagnosis

    NASA Astrophysics Data System (ADS)

    Wang, Shibin; Huang, Weiguo; Zhu, Z. K.

    2011-05-01

    At constant rotating speed, localized faults in rotating machine tend to result in periodic shocks and thus arouse periodic transients in the vibration signal. The transient feature analysis has always been a crucial problem for localized fault detection, and the key aim for transient feature analysis is to identify the model and its parameters (frequency, damping ratio and time index) of the transient, and the time interval, i.e. period, between transients. Based on wavelet and correlation filtering, a technique incorporating transient modeling and parameter identification is proposed for rotating machine fault feature detection. With the proposed method, both parameters of a single transient and the period between transients can be identified from the vibration signal, and localized faults can be detected based on the parameters, especially the period. First, a simulation signal is used to test the performance of the proposed method. Then the method is applied to the vibration signals of different types of bearings with localized faults in the outer race, the inner race and the rolling element, respectively, and all the results show that the period between transients, representing the localized fault characteristic, is successfully detected. The method is also utilized in gearbox fault diagnosis and the effectiveness is verified through identifying the parameters of the transient model and the period. Moreover, it can be drawn that for bearing fault detection, the single-side wavelet model is more suitable than double-side one, while the double-side model for gearbox fault detection. This research proposed an effective method of localized fault detection for rotating machine fault diagnosis through transient modeling and parameter detection.

  20. Classifying performance impairment in response to sleep loss using pattern recognition algorithms on single session testing

    PubMed Central

    St. Hilaire, Melissa A.; Sullivan, Jason P.; Anderson, Clare; Cohen, Daniel A.; Barger, Laura K.; Lockley, Steven W.; Klerman, Elizabeth B.

    2012-01-01

    There is currently no “gold standard” marker of cognitive performance impairment resulting from sleep loss. We utilized pattern recognition algorithms to determine which features of data collected under controlled laboratory conditions could most reliably identify cognitive performance impairment in response to sleep loss using data from only one testing session, such as would occur in the “real world” or field conditions. A training set for testing the pattern recognition algorithms was developed using objective Psychomotor Vigilance Task (PVT) and subjective Karolinska Sleepiness Scale (KSS) data collected from laboratory studies during which subjects were sleep deprived for 26 – 52 hours. The algorithm was then tested in data from both laboratory and field experiments. The pattern recognition algorithm was able to identify performance impairment with a single testing session in individuals studied under laboratory conditions using PVT, KSS, length of time awake and time of day information with sensitivity and specificity as high as 82%. When this algorithm was tested on data collected under real-world conditions from individuals whose data were not in the training set, accuracy of predictions for individuals categorized with low performance impairment were as high as 98%. Predictions for medium and severe performance impairment were less accurate. We conclude that pattern recognition algorithms may be a promising method for identifying performance impairment in individuals using only current information about the individual’s behavior. Single testing features (e.g., number of PVT lapses) with high correlation with performance impairment in the laboratory setting may not be the best indicators of performance impairment under real-world conditions. Pattern recognition algorithms should be further tested for their ability to be used in conjunction with other assessments of sleepiness in real-world conditions to quantify performance impairment in

  1. Dynamic testing of a single-degree-of-freedom strapdown gyroscope

    NASA Technical Reports Server (NTRS)

    Lory, C. B.; Feldman, J.; Sinkiewicz, J. S., Jr.

    1971-01-01

    Test methods and results are presented for the equivalent average input rate of a single-degree-of-freedom gyroscope operated both open loop and with a ternary-logic pulse-torque-to-balance loop during multiaxis angular oscillation. For the open-loop tests, good agreement was obtained with theoretical results. Two-axis testing was performed for oscillations about the Input-Output axes, the Input-Spin axes, and the Spin-Output axes. These tests run in the torque-to-balance mode revealed significant departures from open-loop results in the induced drift rate. An analysis is developed explaining much of the closed-loop data presented. Test data for the gryoscope in a ternary torque-to-balance loop with constant input rates is presented. The tests demonstrate that the instrument rate linearity does not change with interrogation frequency from 3,600 to 14,400 Hz if the torque coil is tuned to offer a resistive load to the current switch. Analysis cited shows that gyroscope lag compensation eliminates multiple pulsing and other equivalent forms of degraded resolution in a wide variety of quantizing loops. This result is test verified for the ternary delta-modulator loop.

  2. Evaluation of disk approximation and single-well broth tests for detection of inducible clindamycin resistance in Streptococcus pneumoniae.

    PubMed

    Jorgensen, James H; McElmeel, M Leticia; Fulcher, Letitia C; McGee, Lesley; Glennen, Anita

    2011-09-01

    This study evaluated an agar disk diffusion D-zone test and an erythromycin-clindamycin (ERY + CLI) single-well broth test for inducible CLI resistance in Streptococcus pneumoniae. The standard CLSI disk approximation test and a single-well combination test incorporating 1 plus 0.5 μg/ml ERY + CLI detected >96% of isolates containing the ermB determinant.

  3. Quantitative estimation of diphtheria and tetanus toxoids. 2. Single radial immuno-diffusion tests (Mancini) and rocket immuno-electrophoresis test in comparison with the flocculation test.

    PubMed

    Ljungqvist, L; Lyng, J

    1987-01-01

    The concentration in Lf units, of an unknown diphtheria or tetanus toxoid preparation is estimated in the flocculation test relative to reference preparations of tetanus and diphtheria antitoxins, respectively. By replacing the antitoxin reference preparations with toxoid reference preparations it should be possible to use immunological methods other than the flocculation test for the quantitative estimation of toxoids in Lf units. A number of diphtheria and tetanus toxoids were tested by rocket immuno-electrophoresis and single radial immuno-diffusion (Mancini test). The concentrations of the unknown toxoids were expressed relative to a diphtheria toxoid calibrated in Lf units (DIFT) and a tetanus toxoid calibrated in Lf units (TEFT), respectively. These two toxoid preparations are regarded as candidates for establishment as international standard preparations. The results obtained in the two tests were compared with those obtained in the flocculation test. In most cases the differences between the results did not exceed 10%. It is concluded, therefore, that the rocket electrophoresis or the radial immuno-diffusion tests can be used as alternatives to the flocculation test.

  4. A Transient Numerical Simulation of Perched Ground-Water Flow at the Test Reactor Area, Idaho National Engineering and Environmental Laboratory, Idaho, 1952-94

    SciTech Connect

    B. R. Orr

    1999-11-01

    Studies of flow through the unsaturated zone and perched ground-water zones above the Snake River Plain aquifer are part of the overall assessment of ground-water flow and determination of the fate and transport of contaminants in the subsurface at the Idaho National Engineering and Environmental Laboratory (INEEL). These studies include definition of the hydrologic controls on the formation of perched ground-water zones and description of the transport and fate of wastewater constituents as they moved through the unsaturated zone. The definition of hydrologic controls requires stratigraphic correlation of basalt flows and sedimentary interbeds within the saturated zone, analysis of hydraulic properties of unsaturated-zone rocks, numerical modeling of the formation of perched ground-water zones, and batch and column experiments to determine rock-water geochemical processes. This report describes the development of a transient numerical simulation that was used to evaluate a conceptual model of flow through perched ground-water zones beneath wastewater infiltration ponds at the Test Reactor Area (TRA).

  5. Testing the effect of transient Plio-Pleistocene barriers in monsoonal Australo-Papua: did mangrove habitats maintain genetic connectivity in the Black Butcherbird?

    PubMed

    Kearns, Anna M; Joseph, Leo; Omland, Kevin E; Cook, Lyn G

    2011-12-01

    Changes in climate and sea level are hypothesized to have promoted the diversification of biota in monsoonal Australia and New Guinea by causing repeated range disjunctions and restricting gene flow between isolated populations. Using a multilocus (one mtDNA locus, five nuclear introns) phylogeographic approach, we test whether populations of the mangrove and rainforest restricted Black Butcherbird (Cracticus quoyi) have diverged across several geographic barriers defined a priori for this region. Phylogeographic structure and estimates of divergence times revealed Plio-Pleistocene divergences and long-term restricted gene flow of populations on either side of four major geographic barriers between and within Australia and New Guinea. Overall, our data are consistent with the hypothesis that mesic-adapted species did not disperse across the open dry woodlands and grasslands that dominated the transient palaeo-landbridges during the Plio-Pleistocene despite the presence of mangrove forests that might have acted as dispersal corridors for mesic-adapted species. Our study offers one of the first multilocus perspectives on the impact of changes in climate and sea level on the population history of widespread species with disjunct ranges in Australia and New Guinea.

  6. Infrastructure Development of Single Cell Testing Capability at A0 Facility

    SciTech Connect

    Dhanaraj, Nandhini; Padilla, R.; Reid, J.; Khabiboulline, T.; Ge, M.; Mukherjee, A.; Rakhnov, I.; Ginsburg, C.; Wu, G.; Harms, E.; Carter, H.; /Fermilab

    2009-09-01

    The objective of this technical note is to document the details of the infrastructure development process that was realized at the A0 photo injector facility to establish RF cold testing capability for 1.3 GHz superconducting niobium single cell cavities. The activity began the last quarter of CY 2006 and ended the first quarter of CY 2009. The whole process involved addressing various aspects such as design of vertical insert and lifting fixture, modification of existing RF test station and design of new couplers, development of a Temperature Mapping (T-Map) system, radiation considerations for the test location (north cave), update of existing High Pressure Rinse (HPR) system, preparation of necessary safety documents and eventually obtaining an Operational Readiness Clearance (ORC). Figure 1 illustrates the various components of the development process. In the past, the north cave test station at A0 has supported the cold testing 3.9 GHz nine cell and single cell cavities, thus some of the components were available for use and some needed modification. The test dewar had the capacity to accommodate 1.3 GHz single cells although a new vertical insert that could handle both cavity types (1.3 and 3.9 GHz) had to be designed. The existing cryogenic system with an average capacity of {approx} 0.5 g/sec was deemed sufficient. The RF system was updated with broadband components and an additional amplifier with higher power capacity to handle higher gradients usually achieved in 1.3 GHz cavities. The initial testing phase was arbitrated to proceed with fixed power coupling. A new temperature mapping system was developed to provide the diagnostic tool for hot spot studies, quench characterization and field emission studies. The defining feature of this system was the use of diode sensors instead of the traditional carbon resistors as sensing elements. The unidirectional current carrying capacity (forward bias) of the diodes provided for the ease of multiplexing of the

  7. Are single-well "push-pull" tests suitable tracer methods for aquifer characterization?

    NASA Astrophysics Data System (ADS)

    Hebig, Klaus; Zeilfelder, Sarah; Ito, Narimitsu; Machida, Isao; Scheytt, Traugott; Marui, Atsunao

    2013-04-01

    Recently, investigations were conducted for geological and hydrogeological characterisation of the sedimentary coastal basin of Horonobe (Hokkaido, Japan). Coastal areas are typical geological settings in Japan, which are less tectonically active than the mountain ranges. In Asia, and especially in Japan, these areas are often densely populated. Therefore, it is important to investigate the behaviour of solutes in such unconsolidated aquifers. In such settings sometimes only single boreholes or groundwater monitoring wells are available for aquifer testing for various reasons, e.g. depths of more than 100 m below ground level and slow groundwater velocities due to density driven flow. A standard tracer test with several involved groundwater monitoring wells is generally very difficult or even not possible at these depths. One of the most important questions in our project was how we can obtain information about chemical and hydraulic properties in such aquifers. Is it possible to characterize solute transport behaviour parameters with only one available groundwater monitoring well or borehole? A so-called "push-pull" test may be one suitable method for aquifer testing with only one available access point. In a push-pull test a known amount of several solutes including a conservative tracer is injected into the aquifer ("push") and afterwards extracted ("pull"). The measured breakthrough curve during the pumping back phase can then be analysed. This method has already been used previously with various aims, also in the recent project (e.g. Hebig et al. 2011, Zeilfelder et al. 2012). However, different test setups produced different tracer breakthrough curves. As no systematic evaluation of this aquifer tracer test method was done so far, nothing is known about its repeatability. Does the injection and extraction rate influence the shape of the breakthrough curve? Which role plays the often applied "chaser", which is used to push the test solution out from the

  8. Single gimbal/strapdown inertial navigation system for use on spin stabilized flight test vehicles

    SciTech Connect

    Watts, A.C.; Andreas, R.D.

    1980-01-01

    A hybrid strapdown inertial navigation system intended for use on spin stabilized flight test vehicles is described. The configuration of the navigator which is briefly described consists of three floated rate integrating gyros, one of which is used in conjunction with the gimbal with the remaining two operated in a rate gyro mode. Outputs from the two strapdown gyros and three accelerometers are digitized and processed by a high performance computer. The navigation algorithms utilize a direction cosine matrix formulation for the attitude computation implemented in the digital computer. The implementation of this algorithm for the single gimbal configuration is described. An accuracy model and results for a reentry vehicle flight test trajectory are presented. The flight test performance from launch to reentry is presented.

  9. Testing The Performance Of A Single-Phase Autotransformer On MATLAB/Simulink

    NASA Astrophysics Data System (ADS)

    Panu, Mihai Gheorghe; Viorel, Alina Cristina

    2015-07-01

    This paper presents a virtual laboratory for testing a single-phase autotransformer using MATLAB Simulink environment. The model is implemented according to a practical laboratory used at electric machines' discipline for the undergraduate level in electrical engineering. The model presented herein is a copy of a practical experiment for an autotransformer made in the test laboratory. The rating of the autotransformer is taken to be 2 kVA, 230/0÷230 V, and it was set at a transformer ratio of 1.5. The used model is a linear one and run for a pure resistive load test. In the same time, it was aimed the simulation accuracy as it was used a linear model, neglecting the magnetic saturation effect.

  10. Transient receptor potential cation channel A1 (TRPA1) mediates changes in heart rate variability following a single exposure to acrolein in mice

    EPA Science Inventory

    The data show that a single exposure to acrolein causes autonomic imbalance in mice through the TRPA1 sensor and subsequent cardiac dysfunction. Human and animal studies have shown that short-term air pollution exposure causes...

  11. Single-dose Intravenous Toxicology Testing of Daebohwalryeok Pharmcopuncture in Sprague-Dawley Rats

    PubMed Central

    Sun, Seung-Ho; Park, Sunju; Jeong, Jong-Jin; Lee, Kwang-Ho; Yu, Jun-Sang; Seo, Hyung-Sik; Kwon, Ki-Rok

    2015-01-01

    Objectives: The aims of the study were to test the single-dose intravenous toxicity of Daebohwalryeok pharmacopuncture (DHRP) in Sprague-Dawley (SD) rats and to estimate the crude lethal dose. Methods: The experiments were conducted at Biotoxtech Co., a Good Laboratory Practice (GLP) laboratory, according to the GLP regulation and were approved by the Institutional Animal Care and Use Committee of Biotoxtech Co. (Approval no: 110156). The rats were divided into three groups: DHRP was injected into the rats in the two test groups at doses of 10 mL/kg and 20 mL/kg, respectively, and normal saline solution was injected into the rats in the control group. Single doses of DHRP were injected intravenously into 6 week old SD rats (5 male and 5 female rats per group). General symptoms were observed and weights were measured during the 14 day observation period after the injection. After the observation period, necropsies were done. Then, histopathological tests were performed. Weight data were analyzed with a one-way analysis of variance (ANOVA) by using statistical analysis system (SAS, version 9.2). Results: No deaths and no statistical significant weight changes were observed for either male or female SD rats in either the control or the test groups during the observation period. In addition, no treatment related general symptoms or necropsy abnormalities were observed. Histopathological results showed no DHRP related effects in the 20 mL/kg DHRP group for either male or female rats. Conclusion: Under the conditions of this study, the results from single-dose intravenous injections of DHRP showed that estimated lethal doses for both male and female rats were above 20 mL/kg. PMID:26120487

  12. Comparing ecotoxicological effect concentrations of chemicals established in multi-species vs. single-species toxicity test systems.

    PubMed

    De Laender, Frederik; De Schamphelaere, Karel A C; Vanrolleghem, Peter A; Janssen, Colin R

    2009-02-01

    Most ecological effect assessment methodologies use effect concentrations derived from single-species testing (ECx,single-species-test) as the basis to estimate 'safe' environmental concentrations (such as environmental quality criteria). Here, we examined to what extent such ECx,single-species-test are representative for population-level effect concentrations in a community setting (ECx,multi-species-test). Data from USEPA's ECOTOX database revealed the existence of considerable scatter around the relationship between ECx,single-species-test (endpoint: mortality) and ECx,multi-species-test (endpoint: population abundance). However, we demonstrate that this scatter is reduced when ECx,single-species-test and ECx,multi-species-test are determined simultaneously and by the same research group. Indeed, if these conditions are fulfilled, the quotient of both ECx values for invertebrates approaches 1 for chemicals that directly target invertebrates. Unfortunately, comparable data for other classes of chemicals and/or taxonomic groups were not found. However, theoretical ecosystem model simulations, which confirmed the results based on the above-mentioned analysis of the ECOTOX database, indicated that for phytoplankton, EC10,single-species-test>EC10,multi-species-test, for chemicals that directly target invertebrates. For chemicals that directly target phytoplankton, the ecosystem model simulations suggest that ECx,single-species-test>ECx,multi-species-test for both phytoplankton and invertebrates. Hence, our observation based on the analysis of existing experimental data that the ECx,single-species-test is similar to the ECx,multi-species-test may be biased by the fact that only data were available for invertebrates and for chemicals targeting invertebrates. Experimental research is required to test the predictions made by the model simulations for phytoplankton as well as for chemicals directly targeting phytoplankton.

  13. 42 CFR 84.1145 - Silica dust test; non-powered single-use dust respirators; minimum requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... minute with a minute volume of 40 liters; a breathing machine cam with a work rate of 622 kg.-m.2/minute... 42 Public Health 1 2011-10-01 2011-10-01 false Silica dust test; non-powered single-use dust... not exceed 1.8 milligrams for any single test....

  14. Beam test results on the detection of single particles and electromagnetic showers with microchannel plates

    NASA Astrophysics Data System (ADS)

    Barnyakov, A.; Barnyakov, M.; Brianza, L.; Cavallari, F.; Ciriolo, V.; Del Re, D.; Gelli, S.; Ghezzi, A.; Gotti, C.; Govoni, P.; Martelli, A.; Marzocchi, B.; Meridiani, P.; Organtini, G.; Paramatti, R.; Pigazzini, S.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Tabarelli de Fatis, T.

    2017-02-01

    I-MCP is an R&D project aimed at the exploitation of secondary emission of electrons from the surface of micro-channel plates (MCP) for single ionizing particles and fast timing of showers in high rate environments. Results from tests with electrons with energies up to 50 GeV of MCP devices with different characteristics are presented. In particular detection efficiency and time resolution are measured for a range of MCP prototypes: different MCP channel diameter and layers configuration are studied. Devices operated in I-MCP configuration, where the particle detection proceed through direct ionization of the MCP layers, are studied in comparison with the more usual PMT-MCP configuration. The results show efficiencies up to 70% for single charge particle detection for I-MCP devices with a time resolution of about 40 ps. The efficiency raise to 100% in response to high energy electromagnetic showers.

  15. A comparison of single-cycle versus multiple-cycle proof testing strategies

    NASA Technical Reports Server (NTRS)

    Hudak, S. J., Jr.; Mcclung, R. C.; Bartlett, M. L.; Fitzgerald, J. H.; Russell, D. A.

    1990-01-01

    An evaluation of single-cycle and multiple-cycle proof testing (MCPT) strategies for SSME components is described. Data for initial sizes and shapes of actual SSME hardware defects are analyzed statistically. Closed-form estimates of the J-integral for surface flaws are derived with a modified reference stress method. The results of load- and displacement-controlled stable crack growth tests on thin IN-718 plates with deep surface flaws are summarized. A J-resistance curve for the surface-cracked configuration is developed and compared with data from thick compact tension specimens. The potential for further crack growth during large unload/reload cycles is discussed, highlighting conflicting data in the literature. A simple model for ductile crack growth during MCPT based on the J-resistance curve is used to study the potential effects of key variables. The projected changes in the crack size distribution during MCPT depend on the interactions between several key parameters, including the number of proof cycles, the nature of the resistance curve, the initial crack size distribution, the component boundary conditions (load vs. displacement control), and the magnitude of the applied load or displacement. The relative advantages of single-cycle and multiple-cycle proof testing appear to be specific, therefore, to individual component geometry, material, and loading.

  16. Testing the efficiency of plant artificial microRNAs by transient expression in Nicotiana benthamiana reveals additional action at the translational level

    PubMed Central

    Yu, Shi; Pilot, Guillaume

    2014-01-01

    Artificial microRNAs (amiRNAs) have become an important tool to assess gene functions due to their high efficiency and specificity to decrease target gene expression. Based on the observed degree of complementarity between microRNAs (miRNAs) and their targets, it was widely accepted that plant miRNAs act at the mRNA stability level, while the animal miRNAs act at the translational level. Contrary to these canonical dogmas, recent evidence suggests that both plant and animal miRNAs act at both levels. Nevertheless, it is still impossible to predict the effect of an artificial miRNA on the stability or translation of the target mRNA in plants. Consequently, identifying and discarding inefficient amiRNAs prior to stable plant transformation would help getting suppressed mutants faster and at reduced cost. We designed and tested a method using transient expression of amiRNAs and the corresponding target genes in Nicotiana benthamiana leaves to test the efficacy of amiRNAs for suppression of the target protein accumulation. The ability of the amiRNAs to suppress the target gene expression in N. benthamiana was then compared to that in stably transformed Arabidopsis. It was found that the efficacy of 16 amiRNAs, targeting a total of four genes, varied greatly. The effects of amiRNAs on target mRNA accumulation did not always correlate with target protein accumulation or the corresponding phenotypes, while a similar trend of the silencing efficacy of amiRNAs could be observed between N. benthamiana and stably transformed Arabidopsis. Our results showed that, similar to endogenous plant miRNAs, plant amiRNAs could act at the translational level, a property needed to be taken into account when testing the efficacy of individual amiRNAs. Preliminary tests in N. benthamiana can help determine which amiRNA would be the most likely to suppress target gene expression in stably transformed plants. PMID:25477887

  17. Event-by-event simulation of single-neutron experiments to test uncertainty relations

    NASA Astrophysics Data System (ADS)

    De Raedt, H.; Michielsen, K.

    2014-12-01

    Results from a discrete-event simulation of a recent single-neutron experiment that tests Ozawa's generalization of Heisenberg's uncertainty relation are presented. The event-based simulation algorithm reproduces the results of the quantum theoretical description of the experiment but does not require the knowledge of the solution of a wave equation, nor does it rely on detailed concepts of quantum theory. In particular, the data from these non-quantum simulations satisfy uncertainty relations derived in the context of quantum theory. Invited paper presented at QTAP-6.

  18. Tomographic test of Bell's inequality for a time-delocalized single photon

    SciTech Connect

    D'Angelo, Milena; Zavatta, Alessandro; Parigi, Valentina; Bellini, Marco

    2006-11-15

    Time-domain balanced homodyne detection is performed on two well-separated temporal modes sharing a single photon. The reconstructed density matrix of the two-mode system is used to prove and quantify its entangled nature, while the Wigner function is employed for an innovative tomographic test of Bell's inequality based on the theoretical proposal by Banaszek and Wodkiewicz [Phys. Rev. Lett. 82, 2009 (1999)]. Provided some auxiliary assumptions are made, a clear violation of the Banaszek-Bell inequality is found.

  19. Single radial immunodiffusion potency test for standardization of indigenous equine influenza vaccine.

    PubMed

    Gupta, A K; Yadav, M P; Uppal, P K

    1993-12-01

    Single radial immunodiffusion (SRD) assays were used for measuring the haemagglutinin antigen contents of equine influenza vaccine prepared from an Indian virus isolate. A/Equine-2/Ludhiana/1/87 (H3N8). Five different preparations of the vaccine were standardized by SRD to prepare 913 doses, each containing 20 micrograms HA/ml-1 dose-1. This test also showed influenza virus subtype specificity as no cross reaction was observed between subtype 1 (H7N7) and subtype 2 (H3N8) viruses.

  20. Single event upset (SEU) of semiconductor devices - A summary of JPL test data

    NASA Technical Reports Server (NTRS)

    Nichols, D. K.; Price, W. E.; Malone, C. J.

    1983-01-01

    The data summarized describe single event upset (bit-flips) for 60 device types having data storage elements. The data are from 15 acceleration tests with both protons and heavier ions. Tables are included summarizing the upset threshold data and listing the devices tested for heavy ion induced bit-flip and the devices tested with protons. With regard to the proton data, it is noted that the data are often limited to one proton energy, since the tests were usually motivated by the engineering requirement of comparing similar candidate devices for a system. It is noted that many of the devices exhibited no upset for the given test conditions (the maximum fluence and the maximum proton energy Ep are given for these cases). It is believed, however, that some possibility of upset usually exists because there is a slight chance that the recoil atom may receive up to 10 to 20 MeV of recoil energy (with more energy at higher Ep).

  1. Consensus statement for inert gas washout measurement using multiple- and single- breath tests.

    PubMed

    Robinson, Paul D; Latzin, Philipp; Verbanck, Sylvia; Hall, Graham L; Horsley, Alexander; Gappa, Monika; Thamrin, Cindy; Arets, Hubertus G M; Aurora, Paul; Fuchs, Susanne I; King, Gregory G; Lum, Sooky; Macleod, Kenneth; Paiva, Manuel; Pillow, Jane J; Ranganathan, Sarath; Ranganathan, Sarah; Ratjen, Felix; Singer, Florian; Sonnappa, Samatha; Stocks, Janet; Subbarao, Padmaja; Thompson, Bruce R; Gustafsson, Per M

    2013-03-01

    Inert gas washout tests, performed using the single- or multiple-breath washout technique, were first described over 60 years ago. As measures of ventilation distribution inhomogeneity, they offer complementary information to standard lung function tests, such as spirometry, as well as improved feasibility across wider age ranges and improved sensitivity in the detection of early lung damage. These benefits have led to a resurgence of interest in these techniques from manufacturers, clinicians and researchers, yet detailed guidelines for washout equipment specifications, test performance and analysis are lacking. This manuscript provides recommendations about these aspects, applicable to both the paediatric and adult testing environment, whilst outlining the important principles that are essential for the reader to understand. These recommendations are evidence based, where possible, but in many places represent expert opinion from a working group with a large collective experience in the techniques discussed. Finally, the important issues that remain unanswered are highlighted. By addressing these important issues and directing future research, the hope is to facilitate the incorporation of these promising tests into routine clinical practice.

  2. Transient receptor potential cation channel A1 (TRPA1) mediates decrements in cardiac mechanical function and dysrhythmia caused by a single air pollution exposure in mice

    EPA Science Inventory

    This work, which will be presented at SOT 2014, demonstrates that a single exposure to either ozone or acrolein causes decrements in cardiac function and altered electrical activity (i.e. arrhythmia). The results suggest that this effect is mediated by the airway sensor TRPA1. ...

  3. Gravitational independence of single-breath washout tests in recumbent dogs

    NASA Technical Reports Server (NTRS)

    Tomioka, Shinichi; Kubo, Susumu; Guy, Harold J. B.; Prisk, G. K.

    1988-01-01

    The effect of gravitational orientation in the mechanism of lung filling and emptying in dogs was examined by conducting simultaneously Ar-bolus and N2 single-breath washout tests (SBWTs) in 10 anesthetized dogs (prone and supine), with three of the dogs subjected to body rotation. Transpulmonary pressure was measured simultaneously, allowing identification of the lung volume above residual volume at which there was an inflection point in the pressure-volume curve. Combined resident gas and bolus SBWTs in recumbent dogs were found to be different from such tests in humans; in dogs, the regional distribution of ventilation was not primarily determined by gravity. The measurements did not make it possible to discern exact mechanisms of filling and emptying, but both processes appear to be related to lung, thorax, and mediastinum interactions and/or differences in regional mechanical properties of the lungs.

  4. Experimental study on the single event effects in pulse width modulators by laser testing

    NASA Astrophysics Data System (ADS)

    Wen, Zhao; Xiaoqiang, Guo; Wei, Chen; Hongxia, Guo; Dongsheng, Lin; Hanning, Wang; Yinhong, Luo; Lili, Ding; Yuanming, Wang

    2015-11-01

    This paper presents single event effect (SEE) characteristics of UC1845AJ pulse width modulators (PWMs) by laser testing. In combination with analysis to map PWM circuitry in the microchip dies, the typical SEE response waveforms for laser pulses located in different circuit blocks of UC1845AJ are obtained and the SEE mechanisms are analyzed. The laser SEE test results show that there are some differences in the SEE mechanisms of different circuit blocks, and phase shifts or changes in the duty cycles of few output pulses are the main SEE behaviors for UC1845AJ. In addition, a new SEE behavior which manifests as changes in the duty cycles of many output pulses is revealed. This means that an SEE hardened design should be considered.

  5. A two-spacecraft test of a single spacecraft method of estimating shock normals

    NASA Technical Reports Server (NTRS)

    Lepping, R. P.

    1972-01-01

    By assuming the validity of a subset of the Rankine-Hugoniot conservation relations for interplanetary (IP) shocks in an isotropic medium it has been demonstrated, in principle, that improved shock normals can be calculated by using a least-squares technique on combined magnetic field and plasma data from a single spacecraft. The scheme uses those six conservation relations not involving pressure and temperature. This paper deals with a test of the scheme by examining in detail a shock across which the magnetic field changed direction by a small amount (approximately 10 deg). On January 26, 1968 at about 1430 UT this shock was observed by the plasma and magnetic field instruments in Explorers 33 and 35. The spacecraft were 76.6 and 56.9 R sub E sunward of the earth, respectively (and 43.5 R sub E from each other), and therefore well outside the earth's bow shock region, a necessary condition for a valid test.

  6. Summary of Group Development and Testing for Single Shell Tank Closure at Hanford

    SciTech Connect

    Harbour, John, R.

    2005-04-28

    This report is a summary of the bench-scale and large scale experimental studies performed by Savannah River National Laboratory for CH2M HILL to develop grout design mixes for possible use in producing fill materials as a part of Tank Closure of the Single-Shell Tanks at Hanford. The grout development data provided in this report demonstrates that these design mixes will produce fill materials that are ready for use in Hanford single shell tank closure. The purpose of this report is to assess the ability of the proposed grout specifications to meet the current requirements for successful single shell tank closure which will include the contracting of services for construction and operation of a grout batch plant. The research and field experience gained by SRNL in the closure of Tanks 17F and 20F at the Savannah River Site was leveraged into the grout development efforts for Hanford. It is concluded that the three Hanford grout design mixes provide fill materials that meet the current requirements for successful placement. This conclusion is based on the completion of recommended testing using Hanford area materials by the operators of the grout batch plant. This report summarizes the regulatory drivers and the requirements for grout mixes as tank fill material. It is these requirements for both fresh and cured grout properties that drove the development of the grout formulations for the stabilization, structural and capping layers.

  7. AGS new fast extraction system and the single bunch extraction test

    SciTech Connect

    Weng, W.T.

    1983-01-01

    For the neutrino physics program and for the CBA injection, a new fast extraction system has been implemented to improve the extraction efficiency and the quality of the extracted beam. Central to the new system is a new fast kicker, placed at the H5 straight section, capable of rising between bunches, t/sub r/ < 170 nsec, and staying constant for 2.6 ..mu..sec with flat top ripple less than +-1.5%. So far, the system has been operated for longer than 3000 hours and routinely extracts 10/sup 13/ ppp at 99% efficiency. Experiment 745 on QCD test requires a single AGS bunch of 40 nsec. For this purpose another fast kicker was placed at the E5 straight section and powered by a new pulser to produce a half sinusoidal pulse with both a rise and fall time of 200 nsec. A single AGS bunch was extracted through the slow beam channel at 22 GeV/c leaving the remaining 11 bunches undisturbed which continued to be accelerated to 29.4 GeV/c and extracted by the H5 kicker through the fast beam channel. Because the ring circumference ratio of CBA to the AGS is 4-3/4, some of the injected beam from the AGS has to contain 11 bunches instead of 12; consequently, this single bunch extraction mode will also be used for CBA injection.

  8. Evaluating quantitative 3-D image analysis as a design tool for low enriched uranium fuel compacts for the transient reactor test facility: A preliminary study

    SciTech Connect

    Kane, J. J.; van Rooyen, I. J.; Craft, A. E.; Roney, T. J.; Morrell, S. R.

    2016-02-05

    In this study, 3-D image analysis when combined with a non-destructive examination technique such as X-ray computed tomography (CT) provides a highly quantitative tool for the investigation of a material’s structure. In this investigation 3-D image analysis and X-ray CT were combined to analyze the microstructure of a preliminary subsized fuel compact for the Transient Reactor Test Facility’s low enriched uranium conversion program to assess the feasibility of the combined techniques for use in the optimization of the fuel compact fabrication process. The quantitative image analysis focused on determining the size and spatial distribution of the surrogate fuel particles and the size, shape, and orientation of voids within the compact. Additionally, the maximum effect of microstructural features on heat transfer through the carbonaceous matrix of the preliminary compact was estimated. The surrogate fuel particles occupied 0.8% of the compact by volume with a log-normal distribution of particle sizes with a mean diameter of 39 μm and a standard deviation of 16 μm. Roughly 39% of the particles had a diameter greater than the specified maximum particle size of 44 μm suggesting that the particles agglomerate during fabrication. The local volume fraction of particles also varies significantly within the compact although uniformities appear to be evenly dispersed throughout the analysed volume. The voids produced during fabrication were on average plate-like in nature with their major axis oriented perpendicular to the compaction direction of the compact. Finally, the microstructure, mainly the large preferentially oriented voids, may cause a small degree of anisotropy in the thermal diffusivity within the compact. α∥/α⊥, the ratio of thermal diffusivities parallel to and perpendicular to the compaction direction are expected to be no less than 0.95 with an upper bound of 1.

  9. Bisulphite sequencing of the transient neonatal diabetes mellitus DMR facilitates a novel diagnostic test but reveals no methylation anomalies in patients of unknown aetiology.

    PubMed

    Mackay, Deborah J G; Temple, I Karen; Shield, Julian P H; Robinson, David O

    2005-03-01

    Transient neonatal diabetes mellitus (TNDM) is associated with overexpression of an imprinted locus on chromosome 6q24; this locus contains a differentially methylated region (DMR) consisting of an imprinted CpG island that normally allows expression only from the paternal allele of genes under its control. Three types of abnormality involving 6q24 are known to cause TNDM: paternal uniparental disomy of chromosome 6 (pUPD6), an isolated methylation defect of the imprinted CpG island at chromosome 6q24 and a duplication of 6q24 of paternal origin. A fourth group of patients has no identifiable anomaly of 6q24. Bisulphite sequencing of the DMR has facilitated the development of a diagnostic test for TNDM based on ratiometric methylation-specific polymerase chain reaction. We have applied this method to 45 cases of TNDM, including 12 with pUPD6, 11 with an isolated methylation mutation at 6q24, 16 with a duplication of 6q24 and six of unknown aetiology, together with 29 normal controls. All were correctly assigned. The method is therefore capable of detecting all known genetic causes of TNDM at 6q24, although pUPD6 and methylation mutation cases are not distinguished from one another. In addition, we have carried out bisulphite sequencing of the DMR to compare its methylation status between six TNDM patients with a known methylation mutation, six patients with no identifiable 6q24 mutation and six normal controls. Whereas methylation mutation patients showed a near-total absence of DNA methylation at the TNDM locus, the patients with no identified molecular anomaly showed no marked methylation variation from controls.

  10. Evaluating quantitative 3-D image analysis as a design tool for low enriched uranium fuel compacts for the transient reactor test facility: A preliminary study

    DOE PAGES

    Kane, J. J.; van Rooyen, I. J.; Craft, A. E.; ...

    2016-02-05

    In this study, 3-D image analysis when combined with a non-destructive examination technique such as X-ray computed tomography (CT) provides a highly quantitative tool for the investigation of a material’s structure. In this investigation 3-D image analysis and X-ray CT were combined to analyze the microstructure of a preliminary subsized fuel compact for the Transient Reactor Test Facility’s low enriched uranium conversion program to assess the feasibility of the combined techniques for use in the optimization of the fuel compact fabrication process. The quantitative image analysis focused on determining the size and spatial distribution of the surrogate fuel particles andmore » the size, shape, and orientation of voids within the compact. Additionally, the maximum effect of microstructural features on heat transfer through the carbonaceous matrix of the preliminary compact was estimated. The surrogate fuel particles occupied 0.8% of the compact by volume with a log-normal distribution of particle sizes with a mean diameter of 39 μm and a standard deviation of 16 μm. Roughly 39% of the particles had a diameter greater than the specified maximum particle size of 44 μm suggesting that the particles agglomerate during fabrication. The local volume fraction of particles also varies significantly within the compact although uniformities appear to be evenly dispersed throughout the analysed volume. The voids produced during fabrication were on average plate-like in nature with their major axis oriented perpendicular to the compaction direction of the compact. Finally, the microstructure, mainly the large preferentially oriented voids, may cause a small degree of anisotropy in the thermal diffusivity within the compact. α∥/α⊥, the ratio of thermal diffusivities parallel to and perpendicular to the compaction direction are expected to be no less than 0.95 with an upper bound of 1.« less

  11. Single element injector cold flow testing for STME swirl coaxial injector element design

    NASA Technical Reports Server (NTRS)

    Hulka, J.; Schneider, J. A.

    1993-01-01

    An oxidizer-swirled coaxial element injector is being investigated for application in the Space Transportation Main Engine (STME). Single element cold flow experiments were conducted to provide characterization of the STME injector element for future analysis, design, and optimization. All tests were conducted to quiescent, ambient backpressure conditions. Spray angle, circumferential spray uniformity, dropsize, and dropsize distribution were measured in water-only and water/nitrogen flows. Rupe mixing efficiency was measured using water/sucrose solution flows with a large grid patternator for simple comparative evaluation of mixing. Factorial designs of experiment were used for statistical evaluation of injector geometrical design features and propellant flow conditions on mixing and atomization. Increasing the free swirl angle of the liquid oxidizer had the greatest influence on increasing the mixing efficiency. The addition of gas assistance had the most significant effect on reducing oxidizer droplet size parameters and increasing droplet size distribution. Increasing the oxidizer injection velocity had the greatest influence for reducing oxidizer droplet size parameters and increasing size distribution for non-gas assisted flows. Single element and multi-element subscale hot fire testing are recommended to verify optimized designs before committing to the STME design.

  12. Negligible shift of 3Ag- potential in longer-chain carotenoids as revealed by a single persistent peak of 3Ag-→1Ag- stimulated emission followed by 3Ag-←1Ag- transient-absorption

    NASA Astrophysics Data System (ADS)

    Li, Chunyong; Miki, Takeshi; Kakitani, Yoshinori; Koyama, Yasushi; Nagae, Hiroyoshi

    2007-12-01

    Upon excitation of lycopene, anhydrorhodovibrin or spirilloxanthin to the 1Bu+(0) state, stimulated emission followed by transient-absorption was observed as a single peak with the 3Ag-(0) energy that had been determined by measurement of resonance-Raman excitation profiles. This observation was explained in terms of negligible shift of the 3Ag- potential, in reference to the 1Ag- potential, where only the 3Ag-(υ)→1Ag-(υ) emission and the 3Ag-(υ)←1Ag-(υ) absorption become allowed during the vibrational relaxation of υ = 2 → 1 → 0, starting from the 3Ag-(2) level generated by diabatic internal conversion from the 1Bu+(0) level, in anhydrorhodovibrin, for example.

  13. Transient transformation of plants.

    PubMed

    Jones, Huw D; Doherty, Angela; Sparks, Caroline A

    2009-01-01

    Transient expression in plants is a valuable tool for many aspects of functional genomics and promoter testing. It can be used both to over-express and to silence candidate genes. It is also scaleable and provides a viable alternative to microbial fermentation and animal cell culture for the production of recombinant proteins. It does not depend on chromosomal integration of heterologous DNA so is a relatively facile procedure and can lead to high levels of transgene expression. Recombinant DNA can be introduced into plant cells via physical methods, via Agrobacterium or via viral vectors.

  14. Fractal analysis of pressure transients in the Geysers Geothermal Field

    SciTech Connect

    Acuna, J.A.; Ershaghi, I.; Yortsos, Y.C.

    1992-01-01

    The conventionally accepted models for the interpretation of pressure transient tests in naturally fractured reservoirs usually involve simplistic assumptions regarding the geometry and transport properties of the fractured medium. Many single well tests in this type of reservoirs fail to show the predicted behavior for dual or triple porosity or permeability systems and cannot be explained by these models. This paper describes the application of a new model based on a fractal interpretation of the fractured medium. The approach, discussed elsewhere [2], [6], is applied to field data from The Geysers Geothermal Field. The objective is to present an alternative interpretation to well tests that characterizes the fractured medium in a manner more consistent with other field evidence. The novel insight gained from fractal geometry allows the identification of important characteristics of the fracture structure that feeds a particular well. Some simple models are also presented that match the field transient results.

  15. Single-center experience of the Korean-Developmental Screening Test for infants and children

    PubMed Central

    Suh, Chae-Ri; Sohn, Su Ye; Kim, Gun-Ha; Jung, Seong-Kwan

    2016-01-01

    Purpose We investigated the number of test takers of the Korean-Developmental Screening Test (K-DST) in a single children's hospital within a year, according to age, referral rate, and follow-up percentage. Methods For this study, 4,062 children who visited and received K-DST at Woorisoa Children's Hospital between January and December 2015 were enrolled. Seven test sets were used according to the Korean National Health Screening Program for infants and children in the following age groups: 4 to 6, 9 to 12, 18 to 24, 30 to 36, 42 to 48, 54 to 60, and 66 to 71 months. The results of the K-DST were categorized into 4 groups as follows: further evaluation (<−2 standard deviation [−2SD]), follow-up test (−2SD to −1SD), peer level (−1SD to 1SD), and high level (>1SD). Results The test participants' population and follow-up population were concentrated before the age of 24 months (2,532, 62.3%). The children most commonly referred for further evaluation were those in the 30- to 41-month age group. A mismatch was found between the results of the K-DST and the additional questions. Most of the infants and children with suspicious developmental delays showed catch-up development in their follow-up tests (43 of 55, 78.2%). Conclusion The use of K-DST should be encouraged, especially among children aged over 24 months. Multiple-choice question format for the additional questions is recommended to avoid confusion. We suggest a nationwide study to evaluate and revise the K-DST. PMID:28194214

  16. Aerobic and Anaerobic Swimming Force Evaluation in One Single Test Session for Young Swimmers.

    PubMed

    de Barros Sousa, Filipe Antônio; Rodrigues, Natalia Almeida; Messias, Leonardo Henrique Dalcheco; Queiroz, Jair Borges; Manchado-Gobatto, Fulvia Barros; Gobatto, Claudio Alexandre

    2017-03-02

    This study aims to propose and validate the tethered swimming lactate minimum test (TSLacmin) estimating aerobic and anaerobic capacity in one single test session, using force as measurement parameter. 6 male and 6 female young swimmers (age=15.7±1.1 years; height=173.3±9.5 cm; weight=66.1±9.5 kg) performed 4 sessions comprising i) an all-out 30 s test and incremental test (TSLacmin); ii) 30 min of tethered swimming at constant intensity (2 sessions); iii) free-swimming time trials used to calculate critical velocity. Tethered swimming sessions used an acquisition system enabling maximum (Fmax) and mean (Fmean) force measurement and intensity variation. The tethered all-out test lasting 30 s resulted in hyperlactatemia of 7.9±2.0 mmol·l(-1). TSLacmin presented a 100% success applicability rate, which is equivalent to aerobic capacity in 75% of cases. TSLacmin intensity was 37.7±7.3 N, while maximum force in the all-out test was 105±27 N. Aerobic and anaerobic TSLacmin parameters were significantly related to free-swimming performance (r=-0.67 for 100 m and r=-0.80 for 200 m) and critical velocity (r=0.80). TSLacmin estimates aerobic capacity in most cases, and both aerobic and anaerobic force parameters are well related to critical velocity and free swimming performance.

  17. Test Analysis Correlation of the Single Stringer Bending Tests for the Space Shuttle ET-137 Intertank Stringer Crack Investigation

    NASA Technical Reports Server (NTRS)

    Phillips, Dawn R.; Saxon, Joseph B.; Wingate, Robert J.

    2012-01-01

    , occurred as the LOX liquid level crossed the LOX tank / Intertank interface ring frame. Hence, cryogenically-induced displacements were suspected as a contributing cause of the stringer cracks. To study the behavior of Intertank stringers subjected to similar displacements, static load tests of individual stringers, colloquially known as "single stringer bending tests" were performed. Approximately thirty stringers were tested, many of which were cut from the partially completed Intertank for what would have been ET-139. In addition to the tests, finite element (FE) analyses of the test configuration were also performed. In this paper, the FE analyses and test-analysis correlation for stringer test S6-8 are presented. Stringer S6-8 is a "short chord" configuration with no doubler panels.

  18. Adhesives: Test Method, Group Assignment, and Categorization Guide for High-Loading-Rate Applications Preparation and Testing of Single Lap Joints (Ver. 2.2, Unlimited)

    DTIC Science & Technology

    2016-04-01

    Assignment, and Categorization Guide for High-Loading- Rate Applications – Preparation and Testing of Single Lap Joints (Ver. 2.2, Unlimited) by...Rate Applications – Preparation and Testing of Single Lap Joints (Ver. 2.2, Unlimited) by Robert Jensen, Daniel DeSchepper, David Flanagan...Gerard Chaney, and Charles Pergantis Weapons and Materials Research Directorate, ARL Coatings, Corrosion, and Engineered Polymers Branch (CCEPB

  19. Semi-analytic approach to analyze single well tracer tests TR-44

    SciTech Connect

    Antunez, E.U.

    1984-08-01

    Residual oil saturation is one of the most important parameters to be considered when analyzing a prospective field for enhanced oil recovery. Traditionally, residual oil saturation has been estimated from cores or well logs. These methods have a small radius of investigation, evaluating saturations in a region close to the wellbore. This region is often affected by injection or production operations. Single well tracer tests have proven to be a better alternative to estimate residual oil saturation since they cover a substantially larger volume of the reservoir, and thus measure a more representative residual oil saturation of the target formation. The method consists of the injection of a reactive tracer that is soluble in oil and water. This tracer slowly hydrolyzes forming a secondary tracer as a product of an irreversible chemical reaction. After injection, the well is shut in to allow the formation of a detectable amount of secondary tracer, which is soluble only in water. When the well is open to production, each tracer arrives to the well at different times. From the separation between the concentration peaks, residual oil saturation is estimated. However, the determination of the residual oil saturation through the analysis of single well tracer test production data, in the past, has required: 1) the use of finite difference simulators, 2) five fitting parameters and 3) considerable man-computer interaction time. In addition finite difference simulators give results that are affected by numerical dispersion. This, and the fitting parameters, add uncertainty to the uniqueness of the solution. In this work, a new approach is presented. The test is analyzed. 28 references, 70 figures, 7 tables.

  20. Single-Crystal NiAl-X Alloys Tested for Hot Corrosion

    NASA Technical Reports Server (NTRS)

    Nesbitt, James A.

    1999-01-01

    Single-crystal nickel aluminide (NiAl) has been investigated extensively throughout the last several years as a potential structural material in aero-gas turbine engines. The attractive features of NiAl in comparison to Ni-base superalloys include a higher melting point, lower density, higher thermal conductivity, and excellent oxidation resistance. However, NiAl suffers from a lack of ductility and fracture toughness at low temperatures and a low creep strength at high temperatures. Alloying additions of hafnium (Hf), gallium (Ga), titanium (Ti), and chromium (Cr) have each shown some benefit to the mechanical properties over that of the binary alloy. However, the collective effect of these alloying additions on the environmental resistance of NiAl-X was unclear. Hence, the present study was undertaken to examine the hot corrosion behavior of these alloys. A companion study examined the cyclic oxidation resistance of these alloys. Several single-crystal NiAl-X alloys (where X is Hf, Ti, Cr, or Ga) underwent hot corrosion testing in a Mach 0.3 burner rig at the NASA Lewis Research Center. Samples were tested for up to 300 1-hr cycles at a temperature of 900 C. It was found that increasing the Ti content from 1 to 5 at.% degraded the hot corrosion behavior. This decline in the behavior was reflected in high weight gains and large corrosion mound formation during testing (see the figures). However, the addition of 1 to 2 at.% Cr to alloys containing 4 to 5 at.% Ti appeared to greatly reduce the susceptibility of these alloys to hot corrosion attack and negated the deleterious effect of the increased Ti addition.

  1. A Comparison of Three IRT Approaches to Examinee Ability Change Modeling in a Single-Group Anchor Test Design

    ERIC Educational Resources Information Center

    Paek, Insu; Park, Hyun-Jeong; Cai, Li; Chi, Eunlim

    2014-01-01

    Typically a longitudinal growth modeling based on item response theory (IRT) requires repeated measures data from a single group with the same test design. If operational or item exposure problems are present, the same test may not be employed to collect data for longitudinal analyses and tests at multiple time points are constructed with unique…

  2. A Compendium of Recent Optocoupler Radiation Test Data

    NASA Technical Reports Server (NTRS)

    Label, K. A.; Kniffin, S. D.; Reed, R. A.; Kim, H. S.; Wert, J. L.; Oberg, D. L.; Normand, E.; Johnston, A. H.; Lum, G. K.; Koga, R.; Day, John H. (Technical Monitor)

    2000-01-01

    We present a compendium of optocoupler radiation test data including neutron, proton and heavy ion Displacement Damage (DD), Single Event Transients (SET) and Total Ionizing Dose (TID). Proton data includes ionizing and non-ionizing damage mechanisms.

  3. Crash tests of four identical high-wing single-engine airplanes

    NASA Technical Reports Server (NTRS)

    Vaughan, V. L., Jr.; Hayduk, R. J.

    1980-01-01

    Four identical four place, high wing, single engine airplane specimens with nominal masses of 1043 kg were crash tested at the Langley Impact Dynamics Research Facility under controlled free flight conditions. These tests were conducted with nominal velocities of 25 m/sec along the flight path angles, ground contact pitch angles, and roll angles. Three of the airplane specimens were crashed on a concrete surface; one was crashed on soil. Crash tests revealed that on a hard landing, the main landing gear absorbed about twice the energy for which the gear was designed but sprang back, tending to tip the airplane up to its nose. On concrete surfaces, the airplane impacted and remained in the impact attitude. On soil, the airplane flipped over on its back. The crash impact on the nose of the airplane, whether on soil or concrete, caused massive structural crushing of the forward fuselage. The liveable volume was maintained in both the hard landing and the nose down specimens but was not maintained in the roll impact and nose down on soil specimens.

  4. A Comparison of Single-Cycle Versus Multiple-Cycle Proof Testing Strategies

    NASA Technical Reports Server (NTRS)

    McClung, R. C.; Chell, G. G.; Millwater, H. R.; Russell, D. A.; Orient, G. E.

    1996-01-01

    Single-cycle and multiple-cycle proof testing (SCPT and MCPT) strategies for reusable aerospace propulsion system components are critically evaluated and compared from a rigorous elastic-plastic fracture mechanics perspective. Earlier MCPT studies are briefly reviewed. New J-integral estimation methods for semi-elliptical surface cracks and cracks at notches are derived and validated. Engineering methods are developed to characterize crack growth rates during elastic-plastic fatigue crack growth (FCG) and the tear-fatigue interaction near instability. Surface crack growth experiments are conducted with Inconel 718 to characterize tearing resistance, FCG under small-scale yielding and elastic-plastic conditions, and crack growth during simulated MCPT. Fractography and acoustic emission studies provide additional insight. The relative merits of SCPT and MCPT are directly compared using a probabilistic analysis linked with an elastic-plastic crack growth computer code. The conditional probability of failure in service is computed for a population of components that have survived a previous proof test, based on an assumed distribution of initial crack depths. Parameter studies investigate the influence of proof factor, tearing resistance, crack shape, initial crack depth distribution, and notches on the MCPT vs. SCPT comparison. The parameter studies provide a rational basis to formulate conclusions about the relative advantages and disadvantages of SCPT and MCPT. Practical engineering guidelines are proposed to help select the optimum proof test protocol in a given application.

  5. A Comparison of Single-Cycle Versus Multiple-Cycle Proof Testing Strategies

    NASA Technical Reports Server (NTRS)

    McClung, R. C.; Chell, G. G.; Millwater, H. R.; Russell, D. A.; Millwater, H. R.

    1999-01-01

    Single-cycle and multiple-cycle proof testing (SCPT and MCPT) strategies for reusable aerospace propulsion system components are critically evaluated and compared from a rigorous elastic-plastic fracture mechanics perspective. Earlier MCPT studies are briefly reviewed. New J-integral estimation methods for semielliptical surface cracks and cracks at notches are derived and validated. Engineering methods are developed to characterize crack growth rates during elastic-plastic fatigue crack growth (FCG) and the tear-fatigue interaction near instability. Surface crack growth experiments are conducted with Inconel 718 to characterize tearing resistance, FCG under small-scale yielding and elastic-plastic conditions, and crack growth during simulated MCPT. Fractography and acoustic emission studies provide additional insight. The relative merits of SCPT and MCPT are directly compared using a probabilistic analysis linked with an elastic-plastic crack growth computer code. The conditional probability of failure in service is computed for a population of components that have survived a previous proof test, based on an assumed distribution of initial crack depths. Parameter studies investigate the influence of proof factor, tearing resistance, crack shape, initial crack depth distribution, and notches on the MCPT versus SCPT comparison. The parameter studies provide a rational basis to formulate conclusions about the relative advantages and disadvantages of SCPT and MCPT. Practical engineering guidelines are proposed to help select the optimum proof test protocol in a given application.

  6. Preliminary Test Results from 650 MHz Single Cell Medium Beta Cavities for Project X

    SciTech Connect

    Marhauser, Frank; Kneisel, Peter; Burrill, Andrew; Kushnick, Peter; Rimmer, R. A.

    2011-07-01

    We have fabricated two single cell 650 MHz {beta}=0.61 cavities of a JLab design, which possibly can be used for the proposed Project X proton linac application. Both cavities were manufactured at JLab from RRR>250 niobium sheet of 4 mm thickness using standard techniques such as deep drawing, electron beam welding, buffered chemical polishing, hydrogen degassing heat treatment, high pressure ultrapure water rinsing and clean room assembly. Initially cavity no. 1 was -- after final surface treatment by buffered chemical polishing (BCP) -- measured without any provisions for stiffening. As expected, the pressure sensitivity and the Lorentz Force detuning coefficients were relatively high; however, the RF performance was very encouraging: the cavity exhibited a Q-value > 10{sup 11} at 1.6K, corresponding to a residual resistance of < 1.5 n{Omega} The initial gradient was limited to E{sub acc} ~ 18 MV/m, limited by field emission. In a subsequent test, the cavity was re-rinsed and stiffened up, resulting in a somewhat improved mechanical behavior, but no improvement in rf performance. The second cavity was also tested twice, before and after low temperature baking. The results from all tests are reported in this contribution.

  7. Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium ssp. paratuberculosis.

    PubMed

    More, S J; Cameron, A R; Strain, S; Cashman, W; Ezanno, P; Kenny, K; Fourichon, C; Graham, D

    2015-08-01

    As part of a broader control strategy within herds known to be infected with Mycobacterium avium ssp. paratuberculosis (MAP), individual animal testing is generally conducted to identify infected animals for action, usually culling. Opportunities are now available to quantitatively compare different testing strategies (combinations of tests) in known infected herds. This study evaluates the effectiveness, cost, and cost-effectiveness of different testing strategies to identify infected animals at a single round of testing within dairy herds known to be MAP infected. A model was developed, taking account of both within-herd infection dynamics and test performance, to simulate the use of different tests at a single round of testing in a known infected herd. Model inputs included the number of animals at different stages of infection, the sensitivity and specificity of each test, and the costs of testing and culling. Testing strategies included either milk or serum ELISA alone or with fecal culture in series. Model outputs included effectiveness (detection fraction, the proportion of truly infected animals in the herd that are successfully detected by the testing strategy), cost, and cost-effectiveness (testing cost per true positive detected, total cost per true positive detected). Several assumptions were made: MAP was introduced with a single animal and no management interventions were implemented to limit within-herd transmission of MAP before this test. In medium herds, between 7 and 26% of infected animals are detected at a single round of testing, the former using the milk ELISA and fecal culture in series 5 yr after MAP introduction and the latter using fecal culture alone 15 yr after MAP introduction. The combined costs of testing and culling at a single round of testing increases with time since introduction of MAP infection, with culling costs being much greater than testing costs. The cost-effectiveness of testing varied by testing strategy. It was also

  8. Compendium of Single-Event Latchup and Total Ionizing Dose Test Results of Commercial Analog to Digital Converters

    NASA Technical Reports Server (NTRS)

    Irom, Farokh; Agarwal, Shri G.

    2012-01-01

    This paper reports single-event latchup and total dose results for a variety of analog to digital converters targeted for possible use in NASA spacecraft's. The compendium covers devices tested over the last 15 years.

  9. Comparing Single species Toxicity Tests to Mesocosm Community-Level Responses to Total Dissolved Solids Comprised of Different Major Ions

    EPA Science Inventory

    Total Dissolved Solids (TDS) dosing studies representing different sources of ions were conducted from 2011-2015. Emergence responses in stream mesocosms were compared to single-species exposures using a whole effluent testing (WET) format and an ex-situ method (single species te...

  10. Workshop on Radio Transients

    NASA Astrophysics Data System (ADS)

    Croft, Steve; Gaensler, Bryan

    2012-04-01

    abstract-type="normal">SummaryWe are entering a new era in the study of variable and transient radio sources. This workshop discussed the instruments and the strategies employed to study those sources, how they are identified and classified, how results from different surveys can be compared, and how radio observations tie in with those at other wavelengths. The emphasis was on learning what common ground there is between the plethora of on-going projects, how methods and code can be shared, and how best practices regarding survey strategy could be adopted. The workshop featured the four topics below. Each topic commenced with a fairly brief introductory talk, which then developed into discussion. By way of preparation, participants had been invited to upload and discuss one slide per topic to a wiki ahead of the workshop. 1. Telescopes, instrumentation and survey strategy. New radio facilities and on-going projects (including upgrades) are both studying the variability of the radio sky, and searching for transients. The discussion first centred on the status of those facilities, and on projects with a time-domain focus, both ongoing and planned, before turning to factors driving choices of instrumentation, such as phased array versus single pixel feeds, the field of view, spatial and time resolution, frequency and bandwidth, depth, area, and cadence of the surveys. 2. Detection, pipelines, and classification. The workshop debated (a) the factors that influence decisions to study variability in the (u,v) plane, in images, or in catalogues, (b) whether, and how much, pipeline code could potentially be shared between one project and another, and which software packages are best for different approaches, (c) how data are stored and later accessed, and (d) how transients and variables are defined and classified. 3. Statistics, interpretation, and synthesis. It then discussed how (i) the choice of facility and strategy and (ii) detection and classification schemes

  11. Definition of Capabilities Needed for a Single Event Effects Test Facility

    SciTech Connect

    Riemer, Bernie; Gallmeier, Franz X.

    2014-12-01

    The Federal Aviation Administration (FAA) is contemplating new regulations mandating testing of the vulnerability of flight-critical avionics to single event effects (SEE). A limited number of high-energy neutron test facilities currently serve the SEE industrial and institutional research community. The FAA recognizes that existing facilities have insufficient test capacity to meet new demand from such mandates; it desires more flexible irradiation capabilities to test complete, large systems and would like capabilities to address greater concerns for thermal neutrons. For this reason, the FAA funded this study by Spallation Neutron Source (SNS) staff with the ultimate aim of developing options for SEE test facilities using high-energy neutrons at the SNS complex. After an investigation of current SEE test practices and assessment of future testing requirements, three concepts were identified covering a range of test functionality, neutron flux levels, and fidelity to the atmospheric neutron spectrum. The costs and times required to complete each facility were also estimated. SEE testing is generally performed by accelerating the event rate to a point where the effects are still dominated by single events and double event causes of failures are negligible. In practice, acceleration factors of as high as 106 are applicable for component testing, whereas for systems testing acceleration factors of 104 seem to be the upper limit. It is strongly desirable that the irradiation facility be tunable over a large range of high-energy neutron fluxes of 102 - 104 n/cm²/s for systems testing and from 104 - 107 n/cm²/s for components testing. The most capable, most flexible, and highest-test-capacity option is a new stand-alone target station named the High-Energy neutron Test Station (HETS). It is also the most expensive option, with a cost to complete of approximately $100 million. Dual test enclosures would

  12. Single and multiple impact ignition of new and aged high explosives in the Steven Impact Test

    SciTech Connect

    Chidester, S K; DePiero, A H; Garza, R G; Tarver, C M

    1999-06-01

    Threshold impact velocities for ignition of exothermic reaction were determined for several new and aged HMX-based solid high explosives using three types of projectiles in the Steven Test. Multiple impact threshold velocities were found to be approximately 10% lower in damaged charges that did not react in one or more prior impacts. Projectiles with protrusions that concentrate the friction work in a small volume of explosive reduced the threshold velocities by approximately 30%. Flat projectiles required nearly twice as high velocities for ignition as rounded projectiles. Blast overpressure gauges were used for both pristine and damaged charges to quantitatively measure reaction violence. Reactive flow calculations of single and multiple impacts with various projectiles suggest that the ignition rates double in damaged charges.

  13. Coupled THM analysis of the single-heater test at yucca mountain

    SciTech Connect

    Blair, S C; Buscheck, T A; Daily, W D; Lin, W; Ramirez, A L

    1999-01-25

    This paper presents a summary of results from the Single-Heater Test (SHT) at Yucca Mountain, Nevada. In the SHT, a horizontal, 5-m-long, line-heat source was used to heat a rock pillar for nine months. Moisture movement was monitored during and after heating using electrical-resistance tomography (ERT) and neutron-logging techniques. Results indicate drying in regions of the rock where temperature reached 60°C and above. The drying zone is asymmetric and is not centered on the heater, but has lobes extending above and to the sides of the heater. Predicted temperatures agreed well with observations. A cold- trap effect was predicted, in the heater borehole, that efficiently transfers heat along the heater borehole to the excavation wall. A simple thermomechanical analysis of the SHT shows that shear zones predicted for vertical fractures coincide with regions of increased moisture content derived from ERT measurements.

  14. Analysis and testing of high entrainment single nozzle jet pumps with variable mixing tubes

    NASA Technical Reports Server (NTRS)

    Hickman, K. E.; Hill, P. G.; Gilbert, G. B.

    1972-01-01

    An analytical model was developed to predict the performance characteristics of axisymmetric single-nozzle jet pumps with variable area mixing tubes. The primary flow may be subsonic or supersonic. The computer program uses integral techniques to calculate the velocity profiles and the wall static pressures that result from the mixing of the supersonic primary jet and the subsonic secondary flow. An experimental program was conducted to measure mixing tube wall static pressure variations, velocity profiles, and temperature profiles in a variable area mixing tube with a supersonic primary jet. Static pressure variations were measured at four different secondary flow rates. These test results were used to evaluate the analytical model. The analytical results compared well to the experimental data. Therefore, the analysis is believed to be ready for use to relate jet pump performance characteristics to mixing tube design.

  15. Kinematic and electromyographic analysis in patients with patellofemoral pain syndrome during single leg triple hop test.

    PubMed

    Kalytczak, Marcelo Martins; Lucareli, Paulo Roberto Garcia; Dos Reis, Amir Curcio; Bley, André Serra; Biasotto-Gonzalez, Daniela Aparecida; Correa, João Carlos Ferrari; Politti, Fabiano

    2016-09-01

    Possible delays in pre-activation or deficiencies in the activity of the dynamic muscle stabilizers of the knee and hip joints are the most common causes of the patellofemoral pain syndrome (PFPS). The aim of the study was to compare kinematic variables and electromyographic activity of the vastus lateralis, biceps femoris, gluteus maximus and gluteus medius muscles between patients with PFPS and health subjects during the single leg triple hop test (SLTHT). This study included 14 female with PFPS (PFPS group) and 14 female healthy with no history of knee pain (Healthy group). Kinematic and EMG data ware collected through participants performed a single session of the SLTHT. The PFPS group exhibited a significant increase (p<0.05) in the EMG activity of the biceps femoris and vastus lateralis muscles, when compared with the healthy group in pre-activity and during the stance phase. This same result was also found for the vastus lateralis muscle (p<0.05) when analyzing the EMG activity during the eccentric phase of the stance phase. In kinematic analysis, no significant differences were found between the groups. These results indicate that biceps femoris and vastus lateralis muscles mainly during the pre-activation phase and stance phases of the SLTHT are more active in PFPS group among healthy group.

  16. Single-String Integration Test Measurements of the NEXT Ion Engine Plume

    NASA Technical Reports Server (NTRS)

    Snyder, Aaron; Kamhawi, Hani; Patterson, Michael; Britton, Melissa

    2005-01-01

    Measurements were made of a 40 cm ion-thruster plume as part of the single-string-integration-test (SSIT) activity of Phase I of the NASA's Evolutionary Xenon Thruster (NEXT) project. The NEXT ion engine incorporates design improvements that extend NSTAR power levels and efficiencies. During SSIT, an engineering model (EM2) 40 cm engine was operated using an advanced xenon propellant system in combination with either a GRC power console or advanced power processing unit. Integral goals of the single-string phase were to characterize engine performance over the full input power range and to detail thruster operation within the specification of the NEXT throttle table. Plume diagnostics measurements of relative Xe(+) and Xe(++) currents were made using near-field and far-field ExB probes. Planar geometry faraday probes were used to obtain beam current density profiles. This paper reports on the characterization of the EM2 plume over a range of SSIT operating conditions, first with the advanced propellant management system teamed with the GRC power console and then with the power-processing unit.

  17. Modeling Single Well Injection-Withdrawal (SWIW) Tests for Characterization of Complex Fracture-Matrix Systems

    SciTech Connect

    Cotte, F.P.; Doughty, C.; Birkholzer, J.

    2010-11-01

    The ability to reliably predict flow and transport in fractured porous rock is an essential condition for performance evaluation of geologic (underground) nuclear waste repositories. In this report, a suite of programs (TRIPOLY code) for calculating and analyzing flow and transport in two-dimensional fracture-matrix systems is used to model single-well injection-withdrawal (SWIW) tracer tests. The SWIW test, a tracer test using one well, is proposed as a useful means of collecting data for site characterization, as well as estimating parameters relevant to tracer diffusion and sorption. After some specific code adaptations, we numerically generated a complex fracture-matrix system for computation of steady-state flow and tracer advection and dispersion in the fracture network, along with solute exchange processes between the fractures and the porous matrix. We then conducted simulations for a hypothetical but workable SWIW test design and completed parameter sensitivity studies on three physical parameters of the rock matrix - namely porosity, diffusion coefficient, and retardation coefficient - in order to investigate their impact on the fracture-matrix solute exchange process. Hydraulic fracturing, or hydrofracking, is also modeled in this study, in two different ways: (1) by increasing the hydraulic aperture for flow in existing fractures and (2) by adding a new set of fractures to the field. The results of all these different tests are analyzed by studying the population of matrix blocks, the tracer spatial distribution, and the breakthrough curves (BTCs) obtained, while performing mass-balance checks and being careful to avoid some numerical mistakes that could occur. This study clearly demonstrates the importance of matrix effects in the solute transport process, with the sensitivity studies illustrating the increased importance of the matrix in providing a retardation mechanism for radionuclides as matrix porosity, diffusion coefficient, or retardation

  18. Crop and Substrate Tests with Single Use Rooting "Pillows" for the VEGGIE Plant Growth Hardware

    NASA Technical Reports Server (NTRS)

    Massa, Gioia; Newsham, Gerard; Caro, Janicce; Stutte, Gary; Morrow, Robert; Wheeler, Raymond

    2011-01-01

    VEGGIE is a small plant production chamber built by ORBITEC. This chamber can be collapsed for easy stowage and deployed in orbit. It is designed for gravity independent operation, and provides 0.17 square m of crop growth area with three primary subsystems: an LED light panel, extendable transparent Teflon bellows to enclose the plants, and a wicking reservoir. VEGGIE would provide the capability for astronauts to grow fresh foods for dietary supplementation. Initial planting concepts tested with the VEGGIE included direct seeding or plug placement on the reservoir surface. These options had issues of salt accumulation and eventual toxicity if the reservoir was filled with nutrient solution, and hardware reuse was limited due to sanitation. In response a rooting packet or "pillow" concept was developed: single-use bags of media containing time release fertilizer with a wicking surface contacting the VEGGIE reservoir. Pillows being tested are small electrostatic bags with a Nitex nylon mesh side, each holding 100 mL of dry media. Six pillows fit in one VEGGIE unit; however pillow size could vary depending on crop selected. Seeds can be planted directly in pillows and planted pillows can be hydrated in space as desired. Our goals were to define optimal media and crops for an ISS mission scenario. Plant tests in pillows were performed in a controlled environment chamber set to habitat-relevant conditions, and capillary reservoir analogs were utilized. Media tested within pillows included: a commercial peat-based potting mix, arcillite (calcined clay), perlite: vermiculite, and peat-based: arcillite blends. Testing included 15 types of leafy greens, snow pea, radish, and herbs. Media performance was crop dependent, but generally plants showed the greatest growth in the peat-based: arcillite mixes. Crops with the best performance in pillows were identified, and testing is underway with select leafy greens examining plant and microbial load response to repeated harvest

  19. Modeling Single Well Injection-Withdrawal (SWIW) Tests for Characterization of Complex Fracture-Matrix Systems

    NASA Astrophysics Data System (ADS)

    Cotte, F.; Doughty, C.; Birkholzer, J. T.

    2010-12-01

    An essential condition for performance evaluation of enhanced geothermal systems (EGS) resides in the ability to reliably predict fluid flow and heat transport in fractured porous rocks, where fast convection-dispersive transport through the fracture network can be strongly affected by heat conduction into the adjacent rock matrix. SWIW tests are single-well tracer tests that involve an initial period of fluid and tracer injection followed by a period of fluid withdrawal. As a result of the flow field reversal, the measured breakthrough curves tend to be less sensitive to advective heterogeneities and more sensitive to matrix diffusion and sorption, making this method very valuable in characterizing fracture-matrix interaction and evaluating matrix properties. In particular, we propose using SWIW tests before and after hydrofracking operations, to help assess the means by which hydrofracking increases permeability and enhances fracture-matrix interaction. In the present study, we have modeled single-well injection-withdrawal (SWIW) tests for non-sorbing and sorbing tracers, using the mixed Eulerian-Lagrangian transport simulator TRIPOLY, which solves tracer advection and dispersion in fracture networks together with solute exchange processes between the fractures and the porous matrix. Our simulations were conducted for hypothetical but workable SWIW test designs considering a variety of statistically generated 2D fracture-matrix systems. Parameter sensitivity studies were completed on three physical parameters of the rock matrix, namely porosity, diffusion coefficient and retardation coefficient, in order to investigate their impact on the fracture-matrix solute exchange process. Hydraulic fracturing, or hydrofracking, was modeled in two different ways, one by increasing the fracture aperture for flow and the other one by adding a new set of fractures to the fracture network. The results of all these different tests were analyzed by studying the population of

  20. Single-well tracer push-pull test sensitivity w. r. to fracture aperture and spacing

    NASA Astrophysics Data System (ADS)

    Ghergut, I.; Behrens, H.; Karmakar, S.; Sauter, M.

    2012-04-01

    Dealing with a parallel-fracture system of infinite lateral extension, four characteristic regimes of tracer signal sensitivity w. r. to fracture aperture and w. r. to fracture spacing s (whose reciprocal defines fracture density, or the fluid-rock interface area per volume) can be identified during the pull phase of a single-well push-pull test, also depending upon the ratio between push-phase duration Tpush and a characteristic time scale Ts (defined by s2 / D = Ts , with D denoting the tracer's effective diffusion coefficient): early-time regime: tracer signals are sensitive w. r. to fracture aperture, but insensitive w. r. to fracture spacing; sensitivity w. r. to fracture aperture first increases, then decreases with Tpush / Ts (thus there will be an optimum in terms of to Tpush / Ts , at early pull times); mid-time regime: tracer signals are sensitive w. r. to fracture spacing, but insensitive w. r. to fracture aperture; sensitivity w. r. to fracture spacing increases with Tpush / Ts ; late-time regime: with increasing pull duration, tracer signals become increasingly insensitive w. r. to fracture spacing, while regaining sensitivity w. r. to fracture aperture; 'very late'-time regime: sensitivity w. r. to fracture aperture becomes independent upon Tpush / Ts . From these different regimes, some recommendations can be derived regarding the design and dimensioning of dual-tracer single-well push-pull tests for the specific purposes of geothermal reservoir characterization, using conservative solutes and heat as tracers. Acknowledgement: This study is funded by MWK Niedersachsen (Lower-Saxony's Science and Culture Ministry) and by Baker Hughes (Celle) within task unit 'G6' of the Collaborative Research Project 'gebo' (Geothermal Energy and High-Performance Drilling).

  1. Test-retest reliability of a single-channel, wireless EEG system.

    PubMed

    Rogers, Jeffrey M; Johnstone, Stuart J; Aminov, Anna; Donnelly, James; Wilson, Peter H

    2016-08-01

    Recording systems to acquire electroencephalogram (EEG) data are traditionally lab-based. However, there are shortcomings to this method, and the ease of use and portability of emerging wireless EEG technologies offer a promising alternative. A previous validity study demonstrated data derived from a single-channel, wireless system (NeuroSky ThinkGear, San Jose, California) is comparable to EEG recorded from conventional lab-based equipment. The current study evaluated the reliability of this portable system using test-retest and reliable change analyses. Relative power (RP) of delta, theta, alpha, and beta frequency bands was derived from EEG data obtained from a single electrode over FP1 in 19 healthy youth (10-17years old), 21 healthy adults (18-28years old), and 19 healthy older adults (55-79years old), during eyes-open, eyes-closed, auditory oddball, and visual n-back conditions. Intra-class correlations (ICCs) and Coefficients of Repeatability (CRs) were calculated from RP data re-collected one-day, one-week, and one-month later. Participants' levels of mood and attention were consistent across sessions. Eyes-closed resting EEG measurements using the portable device were reproducible (ICCs 0.76-0.85) at short and longer retest intervals in all three participant age groups. While still of at least fair reliability (ICCs 0.57-0.85), EEG obtained during eyes-open paradigms was less stable, and any change observed over time during these testing conditions can be interpreted utilizing the CR values provided. Combined with existing validity data, these findings encourage application of the portable EEG system for the study of brain function.

  2. Two interfacial shear strength calculations based on the single fiber composite test

    NASA Astrophysics Data System (ADS)

    Zhandarov, S. F.; Pisanova, E. V.

    1996-07-01

    The fragmentation of a single fiber embedded in a polymer matrix upon stretching (SFC test) provides valuable information on the fiber-matrix bond strength (τ), which determines stress transfer through the interface and, thus, significantly affects the mechanical properties of the composite material. However, the calculated bond strength appears to depend on data interpretation, i.e., on the applied theoretical model, since the direct result of the SFC test is the fiber fragment length distribution rather than the τ value. Two approaches are used in SFC testing for calculation of the bond strength: 1) the Kelly-Tyson model, in which the matrix is assumed to be totally elastic and 2) the Cox model using the elastic constants of the fiber and the matrix. In this paper, an attempt has been made to compare these two approaches employing theory as well as the experimental data of several authors. The dependence of the tensile stress in the fiber and the interfacial shear stress on various factors has been analyzed. For both models, the mean interfacial shear stress in the fragment of critical length (lc) was shown to satisfy the same formula (τ) = (σcD)/2lc, where D is the fiber diameter and σc is the tensile strength of a fiber at gauge length equal to lc. However, the critical lengths from the Kelly-Tyson approach and Cox model are differently related to the fragment length distribution parameters such as the mean fragment length. This discrepancy results in different (τ) values for the same experimental data set. While the main parameter in the Kelly-Tyson model assumed constant for a given fiber-matrix pair is the interfacial shear strength, the ultimate (local) bond strength τult may be seen as the corresponding parameter in the Cox model. Various τult values were obtained for carbon fiber-epoxy matrix systems by analyzing the data of continuously monitored single fiber composite tests. Whereas the mean value of the interfacial shear stress calculated in

  3. Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate

    NASA Astrophysics Data System (ADS)

    Song, Shaozhen; Wei, Wei; Hsieh, Bao-Yu; Pelivanov, Ivan; Shen, Tueng T.; O'Donnell, Matthew; Wang, Ruikang K.

    2016-05-01

    We present single-shot phase-sensitive imaging of propagating mechanical waves within tissue, enabled by an ultrafast optical coherence tomography (OCT) system powered by a 1.628 MHz Fourier domain mode-locked (FDML) swept laser source. We propose a practical strategy for phase-sensitive measurement by comparing the phases between adjacent OCT B-scans, where the B-scan contains a number of A-scans equaling an integer number of FDML buffers. With this approach, we show that micro-strain fields can be mapped with ˜3.0 nm sensitivity at ˜16 000 fps. The system's capabilities are demonstrated on porcine cornea by imaging mechanical wave propagation launched by a pulsed UV laser beam, promising non-contact, real-time, and high-resolution optical coherence elastography.

  4. Scaling submillimeter single-cycle transients toward megavolts per centimeter field strength via optical rectification in the organic crystal OH1.

    PubMed

    Ruchert, Clemens; Vicario, Carlo; Hauri, Christoph P

    2012-03-01

    We present the generation of high-power single-cycle terahertz (THz) pulses in the organic salt crystal 2-[3-(4-hydroxystyryl)-5.5-dimethylcyclohex-2-enylidene]malononitrile or OH1. Broadband THz radiation with a central frequency of 1.5 THz (λ(c)=200 μm) and high electric field strength of 440 kV/cm is produced by optical rectification driven by the signal of a powerful femtosecond optical parametric amplifier. A 1.5% pump to THz energy conversion efficiency is reported, and pulse energy stability better than 1% RMS is achieved. An approach toward the realization of higher field strength is discussed.

  5. Conditioning geostatistical simulations of a bedrock fluvial aquifer using single well pumping tests

    NASA Astrophysics Data System (ADS)

    Niazi, A.; Bentley, L. R.; Hayashi, M.

    2015-12-01

    Geostatistical simulation is a powerful tool to explore the uncertainty associated with heterogeneity in groundwater and reservoir studies. Nonetheless, conditioning simulations merely with lithological information does not utilize all of the available information and so some workers additionally condition simulations with flow data. In this study, we introduce an approach to condition geostatistical simulations of the Paskapoo Formation, which is a paleo-fluvial system consisting of sandstone channels embedded in mudstone. The conditioning data consist of two-hour single well pumping tests extracted from the public water well database in Alberta, Canada. In this approach, lithologic models of an entire watershed are simulated and conditioned with hard lithological data using transition probability geostatistics (TPROGS). Then, a segment of the simulation around a pumping well was used to populate a flow model (FEFLOW) with either sand or mudstone. The values of the hydraulic conductivity and specific storage of sand and mudstone were then adjusted to minimize the difference between simulated and actual pumping test data using the parameter estimation program PEST. If the simulated data do not adequately match the measured data, the lithologic model is updated by locally deforming the lithology distribution using the probability perturbation method (PPM) and the model parameters are again updated with PEST. This procedure is repeated until the simulated and measured data agree within a pre-determined tolerance. The procedure is repeated for each pumping well that has pumping test data. The method constrains the lithological simulations and provides estimates of hydraulic conductivity and specific storage that are consistent with the pumping test data. Eventually, the simulations will be combined in watershed scale groundwater models.

  6. Single-Pass Flow Through (SPFT) Testing of Fluidized-Bed Steam Reforming (FBSR) Waste Forms

    SciTech Connect

    Lorier, T. H.; Pareizs, J. M.; Jantzen, C. M.

    2005-08-15

    Two samples of fluidized-bed steam reforming (FBSR) mineral waste form product were subjected to single-pass flow-through (SPFT) testing. Sample LAW 1123 resulted from pilot-scale FBSR processing with a Hanford Envelope A low-activity waste (LAW) simulant. Sample SBW 1173 resulted from pilot-scale FBSR processing with an Idaho National Laboratory (INL) simulant commonly referred to as sodium-bearing waste (SBW). The pilot-scale waste forms were made at the Science and Technology Applications Research (STAR) facility in Idaho Falls, Idaho. The durability of the two FBSR waste forms was assessed via the SPFT test in this study. Both samples were multiphase mineral waste forms, so the SPFT test results provide an overall release rate from the multiple mineral species in each sample and are dependent on the amount of each phase present and the mineralogy of the phases present. SPFT testing was performed at temperatures of 25, 40, 70, and 90 C on LAW 1123, while SBW 1173 was only tested at 70 and 90 C. The 70 and 90 C data were compared to each other and the LAW-1123 results were compared to previous testing performed by the Pacific Northwest National Laboratory (PNNL) on a LAW Envelope C (high organic content) waste simulant. The objectives of this study were to obtain forward dissolution rate data for both STAR FBSR bed products (using SPFT tests). Also, a qualitative comparison of the FBSR bed products to a glass waste form (specifically the low-activity reference material (LRM) glass) was performed. For these comparisons, the relative surface areas of the FBSR and glass products had to be measured. Due to the more porous and irregular surface of FBSR bed products, the surface area of the bed products was determined using the Brunauer, Emmett, and Teller (BET) measurement method. The surface area of a glass is much smoother and the calculated geometric surface area is typically used for determining dissolution behavior. Presently there are no specifications or

  7. Prototype Test Results for the Single Photon Detection SLR2000 Satellite Laser Ranging System

    NASA Technical Reports Server (NTRS)

    Zagwodzki, Thomas W.; McGarry, Jan F.; Degnan, John J.; Cheek, Jack W.; Dunn, Peter J.; Patterson, Don; Donovan, Howard

    2004-01-01

    NASA's aging Satellite Laser Ranging (SLR) network is scheduled to be replaced over the next few years with a fully automated single photon detection system. A prototype of this new system, called SLR2000, is currently undergoing field trials at the Goddard Space Flight Center in Greenbelt, Maryland to evaluate photon counting techniques and determine system hardware, software, and control algorithm performance levels and limitations. Newly developed diode pumped microchip lasers and quadrant microchannel plate-based photomultiplier tubes have enabled the development of this high repetition rate single photon detection SLR system. The SLR2000 receiver threshold is set at the single photoelectron (pe) level but tracks satellites with an average signal level typically much less than 1 pe. The 2 kHz laser fire rate aids in satellite acquisition and tracking and will enable closed loop tracking by accumulating single photon count statistics in a quadrant detector and using this information to correct for pointing errors. Laser transmitter beamwidths of 10 arcseconds (FWHM) or less are currently being used to maintain an adequate signal level for tracking while the receiver field of view (FOV) has been opened to 40 arcseconds to accommodate point ahead/look behind angular offsets. In the near future, the laser transmitter point ahead will be controlled by a pair of Risley prisms. This will allow the telescope to point behind and enable closure of the receiver FOV to roughly match the transmitter beam divergence. Bandpass filters (BPF) are removed for night tracking operations while 0.2 nm or 1 nm filters are used during daylight operation. Both day and night laser tracking of Low Earth Orbit (LEO) satellites has been achieved with a laser transmitter energy of only 65 microjoules per pulse. Satellite tracking is presently limited to LEO satellites until the brassboard laser transmitter can be upgraded or replaced. Simultaneous tracks have also been observed with NASA s

  8. Single stars in the Hyades open cluster. Fiducial sequence for testing stellar and atmospheric models

    NASA Astrophysics Data System (ADS)

    Kopytova, Taisiya G.; Brandner, Wolfgang; Tognelli, Emanuele; Prada Moroni, Pier Giorgio; Da Rio, Nicola; Röser, Siegfried; Schilbach, Elena

    2016-01-01

    Context. Age and mass determinations for isolated stellar objects remain model-dependent. While stellar interior and atmospheric theoretical models are rapidly evolving, we need a powerful tool to test them. Open clusters are good candidates for this role. Aims: We aim to create a fiducial sequence of stellar objects for testing stellar and atmospheric models. Methods: We complement previous studies on the Hyades multiplicity by Lucky Imaging observations with the AstraLux Norte camera. This allows us to exclude possible binary and multiple systems with companions outside a 2-7 AU separation and to create a single-star sequence for the Hyades. The sequence encompasses 250 main-sequence stars ranging from A5V to M6V. Using the Tool for Astrophysical Data Analysis (TA-DA), we create various theoretical isochrones applying different combinations of interior and atmospheric models. We compare the isochrones with the observed Hyades single-star sequence on J vs. J-Ks, J vs. J-H, and Ks vs. H-Ks color-magnitude diagrams. As a reference we also compute absolute fluxes and magnitudes for all stars from X-ray to mid-infrared based on photometric measurements available in the literature(ROSAT X-ray, GALEX UV, APASS gri, 2MASS JHKs, and WISE W1 to W4). Results: We find that combinations of both PISA and DARTMOUTH stellar interior models with BT-Settl 2010 atmospheric models describe the observed sequence well. We use PISA in combination with BT-Settl 2010 models to derive theoretical predictions for physical parameters (Teff, mass, log g) of 250 single stars in the Hyades. The full sequence covers the mass range of 0.13-2.30 M⊙, and effective temperatures between 3060 K and 8200 K. Conclusions: Within the measurement uncertainties, the current generation of models agree well with the single-star sequence. The primary limitations are the uncertainties in the measurement of the distances to individual Hyades members, and uncertainties in the photometry. Gaia parallaxes

  9. Transient Noise Reduction in Cochlear Implant Users: a Multi-Band Approach

    PubMed Central

    Dyballa, Karl-Heinz; Hehrmann, Phillipp; Hamacher, Volkmar; Lenarz, Thomas; Buechner, Andreas

    2016-01-01

    A previously-tested transient noise reduction (TNR) algorithm for cochlear implant (CI) users was modified to detect and attenuate transients independently across multiple frequency-bands. Since speech and transient noise are often spectrally distinct, we hypothesized that benefits in speech intelligibility can be achieved over the earlier single-band design. Fifteen experienced CI users (49 to 72 years) were tested unilaterally using pre-processed stimuli delivered directly to a speech processor. Speech intelligibility in transient and soft stationary noise, subjective sound quality and the recognition of warning signals was investigated in three processing conditions: no TNR (TNRoff), single-band TNR (TNRsgl) and multi-band TNR (TNRmult). Notably, TNRmult improved speech reception thresholds (SRTs) in cafeteria noise and office noise by up to 3 dB over both TNRoff and TNRsgl, and yielded higher comfort and clarity ratings in cafeteria noise. Our results indicate that multi-band transient noise reduction may be advantageous compared to a single-band approach, and reveal a substantial overall potential for TNR to improve speech perception and listening comfort in CI users. PMID:27942372

  10. Single Event Effects Test Results for Advanced Field Programmable Gate Arrays

    NASA Technical Reports Server (NTRS)

    Allen, Gregory R.; Swift, Gary M.

    2006-01-01

    Reconfigurable Field Programmable Gate Arrays (FPGAs) from Altera and Actel and an FPGA-based quick-turnApplication Specific Integrated Circuit (ASIC) from Altera were subjected to single-event testing using heavy ions. Both Altera devices (Stratix II and HardCopy II) exhibited a low latchup threshold (below an LET of 3 MeV-cm2/mg) and thus are not recommended for applications in the space radiation environment. The flash-based Actel ProASIC Plus device did not exhibit latchup to an effective LET of 75 MeV-cm2/mg at room temperature. In addition, these tests did not show flash cell charge loss (upset) or retention damage. Upset characterization of the design-level flip-flops yielded an LET threshold below 10 MeV-cm2/mg and a high LET cross section of about lxlO-6 cm2/bit for storing ones and about lxl0-7 cm2/bit for storing zeros . Thus, the ProASIC device may be suitable for critical flight applications with appropriate triple modular redundancy mitigation techniques.

  11. Transient tachypnea - newborn

    MedlinePlus

    TTN; Wet lungs - newborns; Retained fetal lung fluid; Transient RDS; Prolonged transition; Neonatal - transient tachypnea ... As the baby grows in the womb, the lungs make a special fluid. This fluid fills the ...

  12. Single decoupled blasthole tests and the significance of the results to presplitting and boulder busting

    SciTech Connect

    Tariq, S.M.; Worsey, P.N.; Wilson, J.W.

    1996-12-01

    The position of a major joint in relation to a blasthole has a significant effect in presplitting. Broad research into the combined effects of firing two decoupled blastholes has been performed in the past. The effects of joints simulated between two blastholes has also been evaluated. However, no attempt has been made to investigate the splitting effects produced by firing a single decoupled blasthole. This paper presents the results of such an investigation. A series of model tests was carried out in specially prepared 12 x 9 x 6 inches concrete blocks each with a 3/8 inch blasthole, loaded with 15-grain detonating cord. To simulate a semi-infinite burden similar to field presplit conditions, the blocks were lightly constrained. Before tightening the blocks, wooden spacers approximately three inches thick were placed on one end of the block to provide a free face. Additional experiments were conducted without constraints to ascertain the resulting fracture pattern in boulder blasting mode. It was found, if the blasthole is relatively near to the free face the angle of crater is greater. It was also observed that, at a distance approximately five times the diameter of the blasthole, the cratering ceases. During these tests a recurring split appeared all the way back to the abutted end of the blocks far in excess of what is expected in presplitting. This was not anticipated. An extensive investigation was undertaken to find an application in presplitting and boulder busting for this new phenomenon. It was found that when the blasthole is placed close to the abutted end of the block, it can produce a significantly longer split than when it is placed near the middle of the block. This was also verified in tests without constraints, which illustrates its potential for application in boulder blasting.

  13. Transient drainage summary report

    SciTech Connect

    1996-09-01

    This report summarizes the history of transient drainage issues on the Uranium Mill Tailings Remedial Action (UMTRA) Project. It defines and describes the UMTRA Project disposal cell transient drainage process and chronicles UMTRA Project treatment of the transient drainage phenomenon. Section 4.0 includes a conceptual cross section of each UMTRA Project disposal site and summarizes design and construction information, the ground water protection strategy, and the potential for transient drainage.

  14. Design and Experimental Test Plan for Hybrid Sulfur Single Cell Pressurized Electrolyzer

    SciTech Connect

    Steeper, T. J.; Steimke, J. L.

    2005-09-01

    The Hybrid Sulfur (HyS) process is one of the leading thermochemical cycles being studied as part of the DOE Nuclear Hydrogen Initiative (NHI). SRNL is conducting analyses and research and development for the Department of Energy on the HyS process. A conceptual design report and development plan for the HyS process was issued on April 1, 2005 [Buckner, et. al., 2005] , and a report on atmospheric testing of a sulfur dioxide depolarized electrolyzer (SDE), a major component of the HyS process, was issued on August 1, 2005 [Steimke, 2005]. The purpose of this report is to document work related to the design and experimental test plan for a pressurized SDE. Pressurized operation of the SDE is a key requirement for development of an efficient and cost-effective HyS process. The HyS process, a hybrid thermochemical cycle proposed and investigated in the 1970s and early 1980s by Westinghouse Electric Corporation, is a high priority candidate for NHI due to the potential for high efficiency and its relatively high level of technical maturity. It was demonstrated in laboratory experiments by Westinghouse in 1978. Process improvements and component advancements that build on that work are being pursued. One of the objectives of the current work is to develop the SDE in order to permit the demonstration of a closed-loop laboratory model of the HyS process. The heart of the HyS process for generating hydrogen is a bank of electrolyzers incorporating sulfur dioxide depolarized anodes. SRNL planned, designed, built and operated a facility for testing single cell electrolyzers at ambient temperature and near atmospheric pressure during the spring and summer of 2005. The major contribution of the SRNL work was the establishment of the proof-of-concept for utilizing the proton-exchange-membrane (PEM) cell design for the SDE operation. Since PEM cells are being extensively developed for automotive fuel cell use, they offer significant potential for cost-effective application for

  15. Analysis of tracer and thermal transients during reinjection

    SciTech Connect

    Kocabas, I.

    1989-10-01

    This work studied tracer and thermal transients during reinjection in geothermal reserviors and developed a new technique which combines the results from interwell tracer tests and thermal injection-backflow tests to estimate the thermal breakthrough times. Tracer tests are essential to determine the degree of connectivity between the injection wells and the producing wells. To analyze the tracer return profiles quantitatively, we employed three mathematical models namely, the convection-dispersion (CD) model, matrix diffusion (MD) model, and the Avodnin (AD) model, which were developed to study tracer and heat transport in a single vertical fracture. We considered three types of tracer tests namely, interwell tracer tests without recirculation, interwell tracer tests with recirculation, and injection-backflow tracer tests. To estimate the model parameters, we used a nonlinear regression program to match tracer return profiles to the solutions.

  16. Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients.

    PubMed

    Marshall-Gradisnik, Sonya; Johnston, Samantha; Chacko, Anu; Nguyen, Thao; Smith, Peter; Staines, Donald

    2016-12-01

    Objective The pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is unknown; however, a small subgroup of patients has shown muscarinic antibody positivity and reduced symptom presentation following anti-CD20 intervention. Given the important roles of calcium (Ca(2+)) and acetylcholine (ACh) signalling in B cell activation and potential antibody development, we aimed to identify relevant single nucleotide polymorphisms (SNPs) and genotypes in isolated B cells from CFS/ME patients. Methods A total of 11 CFS/ME patients (aged 31.82 ± 5.50 years) and 11 non-fatigued controls (aged 33.91 ± 5.06 years) were included. Flow cytometric protocols were used to determine B cell purity, followed by SNP and genotype analysis for 21 mammalian TRP ion channel genes and nine mammalian ACh receptor genes. SNP association and genotyping analysis were performed using ANOVA and PLINK analysis software. Results Seventy-eight SNPs were identified in nicotinic and muscarinic acetylcholine receptor genes in the CFS/ME group, of which 35 were in mAChM3. The remaining SNPs were identified in nAChR delta (n = 12), nAChR alpha 9 (n = 5), TRPV2 (n = 7), TRPM3 (n = 4), TRPM4 (n = 1) mAChRM3 2 (n = 2), and mAChRM5 (n = 3) genes. Nine genotypes were identified from SNPs in TRPM3 (n = 1), TRPC6 (n = 1), mAChRM3 (n = 2), nAChR alpha 4 (n = 1), and nAChR beta 1 (n = 4) genes, and were located in introns and 3' untranslated regions. Odds ratios for these specific genotypes ranged between 7.11 and 26.67 for CFS/ME compared with the non-fatigued control group. Conclusion This preliminary investigation identified a number of SNPs and genotypes in genes encoding TRP ion channels and AChRs from B cells in patients with CFS/ME. These may be involved in B cell functional changes, and suggest a role for Ca(2+) dysregulation in AChR and TRP ion channel signalling in the pathomechanism of CFS/ME.

  17. Single-Event Latchup Testing of the Micrel MIC4424 Dual Power MOSFET Driver

    NASA Technical Reports Server (NTRS)

    Pellish, J. A.; Boutte, A.; Kim, H.; Phan, A.; Topper, A.

    2016-01-01

    We conducted 47 exposures of four different MIC4424 devices and did not observe any SEL or high-current events. This included worst-case conditions with a LET of 81 MeV-sq cm/mg, applied voltage of 18.5 V, a case temperature greater than 120 C, and a final fluence of 1x10(exp 7)/sq cm. We also monitored both the outputs for the presence of SETs. While the period of the 1 MHz square wave was slightly altered in some cases, no pulses were added or deleted. 1. Purpose: The purpose of this testing is to characterize the BiCMOS/DMOS Micrel MIC4424 dual, non-inverting MOSFET driver for single-event latchup (SEL) susceptibility. These data will be used for flight lot evaluation purposes. 2. Devices Tested: The MIC4423/4424/4425 family are highly reliable BiCMOS/DMOS buffer/driver MOSFET drivers. They are higher output current versions of the MIC4426/4427/4428. They can survive up to 5V of noise spiking, of either polarity, on the ground pin. They can accept, without either damage or logic upset, up to half an amp of reverse current (either polarity) forced back into their outputs. Primarily intended for driving power MOSFETs, the MIC4423/4424/4425 drivers are suitable for driving other loads (capacitive, resistive, or inductive) which require low-impedance, high peak currents, and fast switching times. Heavily loaded clock lines, coaxial cables, or piezoelectric transducers are some examples. The only known limitation on loading is that total power dissipated in the driver must be kept within the maximum power dissipation limits of the package. Five (5) parts were provided for SEL testing. We prepared four parts for irradiation and reserved one piece as an un-irradiated control. More information about the devices can be found in Table 1. The parts were prepared for testing by removing the lid from the CDIP package to expose the target die. The parts were then soldered to small copper circuit adapter boards for easy handling. These parts are fabricated in a bulk Bi

  18. CHARACTERIZATION TESTING AND ANALYSIS OF SINGLE CELL SO2 DEPOLARIZED ELECTROLYZER

    SciTech Connect

    Steimke, J; Timothy Steeper, T

    2006-09-15

    This document reports work performed at the Savannah River National Laboratory (SRNL) that further develops the use of a proton exchange membrane or PEM-type electrochemical cell to produce hydrogen via SO{sub 2}-depolarized water electrolysis. This work was begun at SRNL in 2005. This research is valuable in achieving the ultimate goal of an economical hydrogen production process based on the Hybrid Sulfur (HyS) Cycle. The HyS Process is a hybrid thermochemical cycle that may be used in conjunction with advanced nuclear reactors or centralized solar receivers to produce hydrogen by water-splitting. Like all other sulfur-based cycles, HyS utilizes the high temperature thermal decomposition of sulfuric acid to produce oxygen. The unique aspect of HyS is the generation of hydrogen in a water electrolyzer that is operated under conditions where dissolved sulfur dioxide depolarizes the anodic reaction, resulting in substantial voltage reduction. Sulfur dioxide is oxidized at the anode, producing sulfuric acid that is sent to the acid decomposition portion of the cycle. The focus of this work was to conduct single cell electrolyzer tests in order to prove the concept of SO{sub 2}-depolarization and to determine how the results can be used to evaluate the performance of key components of the HyS Process. A test facility for conducting SO{sub 2}-depolarized electrolyzer (SDE) testing was designed, constructed and commissioned. The maximum cell current is 50 amperes, which is equivalent to a hydrogen production rate of approximately 20 liters per hour. Feed to the anode of the electrolyzer is sulfuric acid solutions containing dissolved sulfur dioxide. The partial pressure of sulfur dioxide may be varied in the range of 1 to 6 atm (15 to 90 psia). Temperatures may be controlled in the range from ambient to 80 C. Hydrogen generated at the cathode of the cell is collected for the purpose of flow measurement and composition analysis. The test facility proved to be easy to

  19. Liquid oxygen/hydrogen testing of a single swirl coaxial injector element in a windowed combustion chamber

    NASA Astrophysics Data System (ADS)

    Hulka, J.; Makel, D.

    1993-06-01

    A modular, high pressure, liquid rocket single element combustion chamber was developed at Aerojet for use with nonintrusive combustion diagnostics. The hardware is able to accommodate full-size injection elements and includes a recessed annular injector around the single element to provide a source for hot gas background flow, which reduces recirculation in the chamber and provides additional injection mass to elevate chamber pressure. Experiments are being conducted to develop the diagnostics required to characterize a single-element combustion spray field for combustion modeling, benchmark data for CFD model validation, and development of the transfer functions between single element cold flow and multielement hot fire. The latter task is being pursued using an injector element identical to elements that had been previously cold-flow tested in single element tests to ambient backpressure and hot fire tested in a multielement injector. Preliminary tests conducted to date without hydrogen flowing through the annular coaxial orifice of the single element show the general flow characteristics of a reacting, unconfined, liquid oxygen hollow cone swirl spray.

  20. Single-Marker and Two-Marker Association Tests for Unphased Case-Control Genotype Data, with a Power Comparison

    PubMed Central

    Kim, Sulgi; Morris, Nathan J.; Won, Sungho; Elston, Robert C.

    2009-01-01

    In case-control Single Nucleotide Polymorphism (SNP) data, the Allele frequency, Hardy Weinberg Disequilibrium (HWD) and Linkage Disequilibrium (LD) contrast tests are three distinct sources of information about genetic association. While all three tests are typically developed in a retrospective context, we show that prospective logistic regression models may be developed that correspond conceptually to the retrospective tests. This approach provides a flexible framework for conducting a systematic series of association analyses using unphased genotype data and any number of covariates. For a single stage study, two single-marker tests and four two-marker tests are discussed. The true association models are derived and they allow us to understand why a model with only a linear term will generally fit well for a SNP in weak LD with a causal SNP, whatever the disease model, but not for a SNP in high LD with a non-additive disease SNP. We investigate the power of the association tests using real LD parameters from chromosome 11 in the HapMap CEU population data. Among the single-marker tests, the allelic test has on average the most power in the case of an additive disease; but, for dominant, recessive and heterozygote disadvantage diseases, the genotypic test has the most power. Among the six two-marker tests, the Allelic-LD contrast test, which incorporates linear terms for two markers and their interaction term, provides the most reliable power overall for the cases studied. Therefore, our result supports incorporating an interaction term as well as linear terms in multi-marker tests. PMID:19557751

  1. The Zwicky Transient Facility

    NASA Astrophysics Data System (ADS)

    Kulkarni, Shrinivas R.

    2016-01-01

    The Zwicky Transient Facility (ZTF) has been designed with a singular focus: a systematic exploration of the night sky at a magnitude level well suited for spectral classification and follow up with the existing class of 4-m to 10-m class telescopes. ZTF is the successor to the Palomar Transient Factory (PTF). The discovery engine for ZTF is a 47 square degree camera (realized through 16 e2V monolithic CCDs) that fills the entire focal plane of the 48-inch Oschin telescope of the Palomar Observatory. Single 30-s epoch sensitivity is about 20.5 in g and R bands. The Infarared Processing & Analysis Center (IPAC) is the data center for ZTF. ZTF is a public-private partnership with equal contributions from a consortium of world-wide partners and an NSF MSIP grant. Forty percent of ZTF time is set aside for two major community surveys: a 3-day cadence survey of high latitudes (to mimic LSST) and a time domain survey of the entire Northern Galactic plane. We expect first light in February 2017 and begin a 3-year survey starting summer of 2017. The first year will be spent on building up deep reference images of the sky (a must for transient surveys). During the second year IPAC will deliver near archival quality photometric products within 12 hours of observations. By comparison to reference images photometric alerts will be sent out. Year 3 will see the near real-time release of image differencing products. A Community Science Advisory Committee (CSAC), chaired by S. Ridgway (NOAO), has been set up to both advise the PI and to ensure that the US community's interests are well served. Astronomers interested in getting a head start on ZTF may wish to peruse the data releases from PTF. Young people (or young at heart) may wish to attend the annual summer school on PTF/ZTF (August, Caltech campus). The Principal Investigator (PI) for the project is S. Kulkarni and the Project Scientist is Eric Bellm.For further details please consult http://www.ptf.caltech.edu/ztf

  2. Characterization and single cell testing of Pt/C electrodes prepared by electrodeposition

    NASA Astrophysics Data System (ADS)

    Martín, A. J.; Chaparro, A. M.; Gallardo, B.; Folgado, M. A.; Daza, L.

    Electrodes for proton exchange membrane fuel cells (PEMFC) have been prepared by the electrodeposition method. For this task, the electrodeposition of platinum is carried out on a carbon black substrate impregnated with an ionomer, proton conducting, medium. Before electrodeposition, the substrate is submitted to an activation process to increase the hydrophilic character of the surface to a few microns depth. Electrodeposition of platinum takes place inside the generated surface hydrophilic layer, resulting in a continuous phase covering totally or partially carbon substrate grains. Cross sectional images show a decay profile of platinum towards the interior of the substrate, reflecting a deposition process limited by diffusion of PtCl 6 2- through the porous substrate. Electrodes with different platinum loads have been prepared, and membrane electrode assemblies (MEA) have been mounted with the electrodeposited electrodes as cathode and other standard components (commercial anode and Nafion R 117 membrane). The electrochemically active surface area determined from hydrogen underpotential deposition charge, is lower on the electrodeposited electrodes than on standard electrodes. However, single cell testing shows higher mass specific activity on electrodeposited cathodes with low and intermediate Pt load (below 0.05 mg Pt cm -2).

  3. Initial comparison of single cylinder Stirling engine computer model predictions with test results

    NASA Technical Reports Server (NTRS)

    Tew, R. C., Jr.; Thieme, L. G.; Miao, D.

    1979-01-01

    A NASA developed digital computer code for a Stirling engine, modelling the performance of a single cylinder rhombic drive ground performance unit (GPU), is presented and its predictions are compared to test results. The GPU engine incorporates eight regenerator/cooler units and the engine working space is modelled by thirteen control volumes. The model calculates indicated power and efficiency for a given engine speed, mean pressure, heater and expansion space metal temperatures and cooler water inlet temperature and flow rate. Comparison of predicted and observed powers implies that the reference pressure drop calculations underestimate actual pressure drop, possibly due to oil contamination in the regenerator/cooler units, methane contamination in the working gas or the underestimation of mechanical loss. For a working gas of hydrogen, the predicted values of brake power are from 0 to 6% higher than experimental values, and brake efficiency is 6 to 16% higher, while for helium the predicted brake power and efficiency are 2 to 15% higher than the experimental.

  4. Happy eating: the single target implicit association test predicts overeating after positive emotions.

    PubMed

    Bongers, Peggy; Jansen, Anita; Houben, Katrijn; Roefs, Anne

    2013-08-01

    For many years, questionnaires have been considered the standard when examining emotional eating behavior. However, recently, some controversy has arisen about these questionnaires, and their usefulness in identifying emotional eaters has been questioned. The current study aimed to investigate the Single Target Implicit Association Test (ST-IAT) as a measure of emotional eating. Two ST-IATs (assessing food-positive and food-negative associations respectively) and the Dutch Eating Behaviour Questionnaire (DEBQ) were compared in undergraduate students. A positive, negative or neutral mood was induced by means of a film clip, and milkshake consumption was measured during and after the mood induction. It was hypothesized that participants with strong emotion-food associations on the ST-IATs (i.e., IAT-emotional eaters) would consume more food in the emotion induction condition corresponding to that emotion, as compared to those with weak emotion-food associations as well as to those in the neutral condition. Participants who scored high on both the positive and negative ST-IATs ate more during a positive mood induction than during a negative mood induction. This effect did not extend to milkshake consumption after the mood induction procedure. In addition, IAT-positive emotional eaters consumed more food than IAT-non-emotional eaters. No effects of the DEBQ on milkshake consumption were found. It is concluded that the ST-IAT has potential as a measure of emotional eating.

  5. Perturbations for transient acceleration

    SciTech Connect

    Vargas, Cristofher Zuñiga; Zimdahl, Winfried; Hipólito-Ricaldi, Wiliam S. E-mail: hipolito@ceunes.ufes.br

    2012-04-01

    According to the standard ΛCDM model, the accelerated expansion of the Universe will go on forever. Motivated by recent observational results, we explore the possibility of a finite phase of acceleration which asymptotically approaches another period of decelerated expansion. Extending an earlier study on a corresponding homogeneous and isotropic dynamics, in which interactions between dark matter and dark energy are crucial, the present paper also investigates the dynamics of the matter perturbations both on the Newtonian and General Relativistic (GR) levels and quantifies the potential relevance of perturbations of the dark-energy component. In the background, the model is tested against the Supernova type Ia (SNIa) data of the Constitution set and on the perturbative level against growth rate data, among them those of the WiggleZ survey, and the data of the 2dFGRS project. Our results indicate that a transient phase of accelerated expansion is not excluded by current observations.

  6. Correlation of single-breath count test and neck flexor muscle strength with spirometry in myasthenia gravis

    PubMed Central

    Elsheikh, Bakri; Arnold, W. David; Gharibshahi, Shahram; Reynolds, Jerold; Freimer, Miriam; Kissel, John T.

    2015-01-01

    Introduction Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. Method We conducted a prospective, cross-sectional, single-blind study in adults with acetylcholine receptor antibody positive MG. Participants performed the single breath count test (SBCT) and underwent manual muscle strength testing, while a respiratory therapist performed spirometry blinded to SBCT and strength results. Results Thirty-one patients, aged 57 ±19 years participated. SBCT showed significant correlations with forced vital capacity (FVC), negative inspiratory force (NIF), and neck flexor strength (P<0.01). FVC showed significant correlation with neck flexor strength (P=0.02) but no correlation with shoulder abductor strength. Discussion These data suggest that the SBCT and neck flexor strength testing are valuable tools for bedside assessment of respiratory function in MG patients. PMID:26437790

  7. SEU and Test Considerations for FPGA Devices

    NASA Technical Reports Server (NTRS)

    Berg, Malanie

    2006-01-01

    This viewgraph presentation provides an overview of Field Programmable Gate Arrays (FPGAs), what they are, implementations in space missions, and current available technologies. Single Event Upsets (SEUs) and Single Event Transients (SETs) are discussed in relation to their effects on FPGAs. Testing goals, considerations, and data analysis are reviewed.

  8. Evaluation of naked eye single tube red cell osmotic fragility test in detecting beta-thalassemia trait.

    PubMed

    Raghavan, K; Lokeshwar, M R; Birewar, N; Nigam, V; Manglani, M V; Raju, N B

    1991-05-01

    The Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) was applied to 4 groups of subjects: (i) Normal; (ii) Proven beta-thalassemia trait carriers; (iii) Iron deficiency anemia; and (iv) other hemoglobinopathies, to evaluate its effectiveness as a screening test for beta-thalassemia minor. The test was successful in detecting 105/110 subjects with beta-thalassemia trait. The sensitivity of the test was 95.5% and specificity was 87%. The predictive value of the positive test was 70.5% and that of the negative test was 98.3%. NESTROFT was also positive in 9/17 subjects with HbS trait, in 3/3 subjects with HbD trait and in 1/1 subjects with HbE trait. The test proved to be simple, cheap, easy to perform and adaptable for field surveys, coming close to an ideal screening test for beta-thalassemia minor.

  9. Fracture trace map and single-well aquifer test results in a carbonate aquifer in Berkeley County, West Virginia

    USGS Publications Warehouse

    McCoy, Kurt J.; Podwysocki, Melvin H.; Crider, E. Allen; Weary, David J.

    2005-01-01

    These data contain information on the results of single-well aquifer tests, lineament analysis, and a bedrock geologic map compilation for the low-lying carbonate and shale areas of eastern Berkeley County, West Virginia. Efforts have been initiated by management agencies of Berkeley County in cooperation with the U.S. Geological Survey to further the understanding of the spatial distribution of fractures in the carbonate regions and their correlation with aquifer properties. This report presents transmissivity values from about 200 single-well aquifer tests and a map of fracture-traces determined from aerial photos and field investigations. Transmissivity values were compared to geologic factors possibly affecting its magnitude.

  10. Single-Event Effects Ground Testing and On-Orbit Rate Prediction Methods: The Past, Present and Future

    NASA Technical Reports Server (NTRS)

    Reed, Robert A.; Kinnison, Jim; Pickel, Jim; Buchner, Stephen; Marshall, Paul W.; Kniffin, Scott; LaBel, Kenneth A.

    2003-01-01

    Over the past 27 years, or so, increased concern over single event effects in spacecraft systems has resulted in research, development and engineering activities centered around a better understanding of the space radiation environment, single event effects predictive methods, ground test protocols, and test facility developments. This research has led to fairly well developed methods for assessing the impact of the space radiation environment on systems that contain SEE sensitive devices and the development of mitigation strategies either at the system or device level.

  11. Platelet function testing during 5-day storage of single and random donor plateletpheresis.

    PubMed

    Akay, O Meltem; Gündüz, Eren; Başyiğit, Hatice; Gulbas, Zafer

    2007-06-01

    Platelet concentrates are routinely manufactured from whole blood by differential centrifugation (random donor platelets-RDP) or by plateletpheresis (single donor platelets-SDP). These platelet concentrates have a storage period of 5 days and many different approaches exist to measure the condition of platelets during their storage. In this study, platelet aggregation testing using adenosine diphosphate (ADP) and collagen and flow cytometric platelet activation analysis using CD41 FITC and CD62 PE before and after ADP was performed on days 1, 3 and 5 of storage of platelet preparations. Thirty three RDPs, stored in Baxter and Kansuk blood bags and 18 SDPs stored in Fresenius blood bags were evaluated. In RDPs and in SDPs; ADP and collagen induced PA responses were decreased significantly on the 3rd and 5th days compared to 1st day. CD62 positive platelet percentage after ADP were decreased significantly on the 3rd and 5th days compared to the 1st day in Kansuk bags. Flow cytometric analysis revealed minor changes in CD41 expression after ADP on the 3rd day compared to 1st day and on the 5th day compared to 3rd day. Differences in CD62 positive platelet percentage were not significant between the RDPs and SDPs. Our results suggest that: (1) ADP and collagen induced PA responses decrease both in RDPs and SDPs during storage. (2) Flow cytometric analysis does not show major significant changes in platelet activation after ADP during storage. (3) Continous shaking on the agitator does not cause a significant change in CD62 positive platelet percentage during storage. (4) Platelet aggregation responses in RDPs stored in Baxter and Kansuk blood bags do not differ during storage.

  12. Local strain and damage mapping in single trabeculae during three-point bending tests.

    PubMed

    Jungmann, R; Szabo, M E; Schitter, G; Tang, Raymond Yue-Sing; Vashishth, D; Hansma, P K; Thurner, P J

    2011-05-01

    The use of bone mineral density as a surrogate to diagnose bone fracture risk in individuals is of limited value. However, there is growing evidence that information on trabecular microarchitecture can improve the assessment of fracture risk. One current strategy is to exploit finite element analysis (FEA) applied to 3D image data of several mm-sized trabecular bone structures obtained from non-invasive imaging modalities for the prediction of apparent mechanical properties. However, there is a lack of FE damage models, based on solid experimental facts, which are needed to validate such approaches and to provide criteria marking elastic-plastic deformation transitions as well as microdamage initiation and accumulation. In this communication, we present a strategy that could elegantly lead to future damage models for FEA: direct measurements of local strains involved in microdamage initiation and plastic deformation in single trabeculae. We use digital image correlation to link stress whitening in bone, reported to be correlated to microdamage, to quantitative local strain values. Our results show that the whitening zones, i.e. damage formation, in the presented loading case of a three-point bending test correlate best with areas of elevated tensile strains oriented parallel to the long axis of the samples. The average local strains along this axis were determined to be (1.6±0.9)% at whitening onset and (12±4)% just prior to failure. Overall, our data suggest that damage initiation in trabecular bone is asymmetric in tension and compression, with failure originating and propagating over a large range of tensile strains.

  13. Local strain and damage mapping in single trabeculae during three-point bending tests

    PubMed Central

    Jungmann, R.; Szabo, M.E.; Schitter, G.; Tang, Raymond Yue-Sing; Vashishth, D.; Hansma, P.K.; Thurner, P.J.

    2012-01-01

    The use of bone mineral density as a surrogate to diagnose bone fracture risk in individuals is of limited value. However, there is growing evidence that information on trabecular microarchitecture can improve the assessment of fracture risk. One current strategy is to exploit finite element analysis (FEA) applied to 3D image data of several mm-sized trabecular bone structures obtained from non-invasive imaging modalities for the prediction of apparent mechanical properties. However, there is a lack of FE damage models, based on solid experimental facts, which are needed to validate such approaches and to provide criteria marking elastic–plastic deformation transitions as well as microdamage initiation and accumulation. In this communication, we present a strategy that could elegantly lead to future damage models for FEA: direct measurements of local strains involved in microdamage initiation and plastic deformation in single trabeculae. We use digital image correlation to link stress whitening in bone, reported to be correlated to microdamage, to quantitative local strain values. Our results show that the whitening zones, i.e. damage formation, in the presented loading case of a three-point bending test correlate best with areas of elevated tensile strains oriented parallel to the long axis of the samples. The average local strains along this axis were determined to be (1.6 ± 0.9)% at whitening onset and (12 ± 4)% just prior to failure. Overall, our data suggest that damage initiation in trabecular bone is asymmetric in tension and compression, with failure originating and propagating over a large range of tensile strains. PMID:21396601

  14. Validation of a Pressure-Based Combustion Simulation Tool Using a Single Element Injector Test Problem

    NASA Technical Reports Server (NTRS)

    Thakur, Siddarth; Wright, Jeffrey

    2006-01-01

    The traditional design and analysis practice for advanced propulsion systems, particularly chemical rocket engines, relies heavily on expensive full-scale prototype development and testing. Over the past decade, use of high-fidelity analysis and design tools such as CFD early in the product development cycle has been identified as one way to alleviate testing costs and to develop these devices better, faster and cheaper. Increased emphasis is being placed on developing and applying CFD models to simulate the flow field environments and performance of advanced propulsion systems. This necessitates the development of next generation computational tools which can be used effectively and reliably in a design environment by non-CFD specialists. A computational tool, called Loci-STREAM is being developed for this purpose. It is a pressure-based, Reynolds-averaged Navier-Stokes (RANS) solver for generalized unstructured grids, which is designed to handle all-speed flows (incompressible to hypersonic) and is particularly suitable for solving multi-species flow in fixed-frame combustion devices. Loci-STREAM integrates proven numerical methods for generalized grids and state-of-the-art physical models in a novel rule-based programming framework called Loci which allows: (a) seamless integration of multidisciplinary physics in a unified manner, and (b) automatic handling of massively parallel computing. The objective of the ongoing work is to develop a robust simulation capability for combustion problems in rocket engines. As an initial step towards validating this capability, a model problem is investigated in the present study which involves a gaseous oxygen/gaseous hydrogen (GO2/GH2) shear coaxial single element injector, for which experimental data are available. The sensitivity of the computed solutions to grid density, grid distribution, different turbulence models, and different near-wall treatments is investigated. A refined grid, which is clustered in the vicinity of

  15. Racial/ethnic and gender differences among older adults in nonmonogamous partnerships, time spent single, and HIV testing

    PubMed Central

    Harawa, Nina T.; Leng, Mei; Kim, Junyeop; Cunningham, William Emery

    2011-01-01

    Background A higher frequency of nonmonogamy, due in part to lower marriage prevalence, may contribute to elevated HIV/STD rates among older Blacks. Methods To examine race and gender differences in nonmonogamy, time spent single (i.e., not married or cohabiting), and HIV testing in older adults, we analyzed U.S. population-based data from the 2005-06 National Social Life, Health, and Aging Project (NSHAP) for 2,825 heterosexual participants ages 57-85 years. Results Blacks spent greater portions of their adult lives single than did Hispanics or Whites and were far more likely to report recent nonmonogamous partnerships (23.4% vs. 10.0% and 8.2%). Among individuals reporting sex in the prior 5 years, nonmonogamous partnerships were strongly associated with time spent single during the period. Control for time spent single and other covariates reduced the association of Black race with nonmonogamous partnerships for men but increased it for women. Less than 20% reported ever testing for HIV; less than 6% had been recommended testing by a provider. Testing rates, highest in Black men and White women, differed little by history of nonmonogamous partnerships within gender strata. Conclusions Singlehood helps to explain higher nonmonogamous partnership rates in older Black men but not older Black women. Older adults rarely receive or are recommended HIV testing, a key strategy for reducing heterosexual HIV transmission. PMID:22082721

  16. Out-of-School Time Program Test Score Impact for Black Children of Single-Parents

    ERIC Educational Resources Information Center

    Nagle, Barry T.

    2013-01-01

    Out-of-School Time programs and their impact on standardized college entrance exam scores for black or African-American children of single parents who have applied for a competitive college scholarship program is the study focus. Study importance is supported by the large percentage of black children raised by single parents, the large percentage…

  17. Superresolution microscopy with transient binding.

    PubMed

    Molle, Julia; Raab, Mario; Holzmeister, Susanne; Schmitt-Monreal, Daniel; Grohmann, Dina; He, Zhike; Tinnefeld, Philip

    2016-06-01

    For single-molecule localization based superresolution, the concentration of fluorescent labels has to be thinned out. This is commonly achieved by photophysically or photochemically deactivating subsets of molecules. Alternatively, apparent switching of molecules can be achieved by transient binding of fluorescent labels. Here, a diffusing dye yields bright fluorescent spots when binding to the structure of interest. As the binding interaction is weak, the labeling is reversible and the dye ligand construct diffuses back into solution. This approach of achieving superresolution by transient binding (STB) is reviewed in this manuscript. Different realizations of STB are discussed and compared to other localization-based superresolution modalities. We propose the development of labeling strategies that will make STB a highly versatile tool for superresolution microscopy at highest resolution.

  18. Experimental test of single-system steering and application to quantum communication

    NASA Astrophysics Data System (ADS)

    Liu, Zhao-Di; Sun, Yong-Nan; Cheng, Ze-Di; Xu, Xiao-Ye; Zhou, Zong-Quan; Chen, Geng; Li, Chuan-Feng; Guo, Guang-Can

    2017-02-01

    Einstein-Podolsky-Rosen (EPR) steering describes the ability to steer remotely quantum states of an entangled pair by measuring locally one of its particles. Here we report on an experimental demonstration of single-system steering. The application to quantum communication is also investigated. Single-system steering refers to steering of a single d -dimensional quantum system that can be used in a unifying picture to certify the reliability of tasks employed in both quantum communication and quantum computation. In our experiment, high-dimensional quantum states are implemented by encoding polarization and orbital angular momentum of photons with dimensionality of up to 12.

  19. Criticality of Low-Energy Protons in Single-Event Effects Testing of Highly-Scaled Technologies

    NASA Technical Reports Server (NTRS)

    Pellish, Jonathan A.; Marshall, Paul W.; Rodbell, Kenneth P.; Gordon, Michael S.; LaBel, Kenneth A.; Schwank, James R.; Dodds, Nathaniel A.; Castaneda, Carlos M.; Berg, Melanie D.; Kim, Hak S.; Phan, Anthony M.; Seidleck, Christina M.

    2014-01-01

    We report low-energy proton and low-energy alpha particle single-event effects (SEE) data on a 32 nm silicon-on-insulator (SOI) complementary metal oxide semiconductor (CMOS) latches and static random access memory (SRAM) that demonstrates the criticality of using low-energy protons for SEE testing of highly-scaled technologies. Low-energy protons produced a significantly higher fraction of multi-bit upsets relative to single-bit upsets when compared to similar alpha particle data. This difference highlights the importance of performing hardness assurance testing with protons that include energy distribution components below 2 megaelectron-volt. The importance of low-energy protons to system-level single-event performance is based on the technology under investigation as well as the target radiation environment.

  20. Testing a Poisson Counter Model for Visual Identification of Briefly Presented, Mutually Confusable Single Stimuli in Pure Accuracy Tasks

    ERIC Educational Resources Information Center

    Kyllingsbaek, Soren; Markussen, Bo; Bundesen, Claus

    2012-01-01

    The authors propose and test a simple model of the time course of visual identification of briefly presented, mutually confusable single stimuli in pure accuracy tasks. The model implies that during stimulus analysis, tentative categorizations that stimulus i belongs to category j are made at a constant Poisson rate, v(i, j). The analysis is…