75 FR 76041 - Chrysler Group LLC Formerly Known as Chrysler LLC Kenosha Engine Plant Including On-Site Leased...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... Formerly Known as Chrysler LLC Kenosha Engine Plant Including On-Site Leased Workers From Caravan Knight..., K+S Services, Inc., G4S Secure Solutions, Crassociates, Inc., CES, Inc., Evans Distribution Systems..., LLC, formerly known as Chrysler, LLC, Kenosha Engine Plant, Kenosha, Wisconsin (subject firm). The...

Important Earthquake Engineering Resources

Science.gov Websites

PEER logo Pacific Earthquake Engineering Research Center home about peer news events research Engineering Resources Site Map Search Important Earthquake Engineering Resources - American Concrete Institute Motion Observation Systems (COSMOS) - Consortium of Universities for Research in Earthquake Engineering

Effective hydrogen generator testing for on-site small engine

NASA Astrophysics Data System (ADS)

Chaiwongsa, Praitoon; Pornsuwancharoen, Nithiroth; Yupapin, Preecha P.

2009-07-01

We propose a new concept of hydrogen generator testing for on-site small engine. In general, there is a trade-off between simpler vehicle design and infrastructure issues, for instance, liquid fuels such as gasoline and methanol for small engine use. In this article we compare the hydrogen gases combination the gasoline between normal systems (gasoline only) for small engine. The advantage of the hydrogen combines gasoline for small engine saving the gasoline 25%. Furthermore, the new concept of hydrogen combination for diesel engine, bio-diesel engine, liquid petroleum gas (LPG), natural gas vehicle (NGV), which is discussed in details.

Engineered Proteins Program Mammalian Cells to Target Inflammatory Disease Sites.

PubMed

Qudrat, Anam; Mosabbir, Abdullah Al; Truong, Kevin

2017-06-22

Disease sites in atherosclerosis and cancer feature cell masses (e.g., plaques/tumors), a low pH extracellular microenvironment, and various pro-inflammatory cytokines such as tumor necrosis factor α (TNFα). The ability to engineer a cell to seek TNFα sources allows for targeted therapeutic delivery. To accomplish this, here we introduced a system of proteins: an engineered TNFα chimeric receptor (named TNFR1chi), a previously engineered Ca 2+ -activated RhoA (named CaRQ), vesicular stomatitis virus glycoprotein G (VSVG), and thymidine kinase. Upon binding TNFα, TNFR1chi generates a Ca 2+ signal that in turn activates CaRQ-mediated non-apoptotic blebs that allow migration toward the TNFα source. Next, the addition of VSVG, upon low pH induction, causes membrane fusion of the engineered and TNFα source cells. Finally, after ganciclovir treatment cells undergo death via the thymidine kinase suicide mechanism. Hence, we assembled a system of proteins that forms the basis of engineering a cell to target inflammatory disease sites characterized by TNFα secretion and a low-pH microenvironment. Copyright © 2017 Elsevier Ltd. All rights reserved.

The 2015-2016 SEPMAP Program at NASA JSC: Science, Engineering, and Program Management Training

NASA Technical Reports Server (NTRS)

Graham, L.; Archer, D.; Bakalyar, J.; Berger, E.; Blome, E.; Brown, R.; Cox, S.; Curiel, P.; Eid, R.; Eppler, D.;

SUPERFUND TREATABILITY CLEARINGHOUSE: EVALUATION OF AN ENGINEERED BIODEGRADATION SYSTEM AT THE NASHUA, N.H. SITE

EPA Science Inventory

The treatability study report presents the results of both laboratory and field studies conducted by Koppers on soils from the Nashua, N.H., NPL site. The purpose of these studies was to provide the necessary data to evaluate a ull-scale design for the Engineered Biodeg...

Analyzing Web Server Logs to Improve a Site's Usage. The Systems Librarian

ERIC Educational Resources Information Center

Breeding, Marshall

2005-01-01

This column describes ways to streamline and optimize how a Web site works in order to improve both its usability and its visibility. The author explains how to analyze logs and other system data to measure the effectiveness of the Web site design and search engine.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wade C. Adams

From the mid-1950s until mid-2000, the Combustion Engineering, Inc. (CE) site in Windsor, Connecticut (Figure A-1) was involved in the research, development, engineering, production, and servicing of nuclear fuels, systems, and services. The site is currently undergoing decommissioning that will lead to license termination and unrestricted release in accordance with the requirements of the License Termination Rule in 10 CFR Part 20, Subpart E. Asea Brown Boveri Incorporated (ABB) has been decommissioning the CE site since 2001.

77 FR 21587 - Bayer Cropscience, LP, Including On-Site Leased Workers From Jacobs PSG, Middough Associates, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-10

...., Digital Management Group, Mercury Air Group, Inc., Greenwood, and Professional Maintenance of Charleston... Solutions, Becht Engineering, Engineering Support Systems, Manufacturing Management Services, US Securities, WB Wells, Belcan, American Engineers, CH2M Hill Engineers, Inc., Digital Management Group, Mercury...

47 CFR 27.1164 - The cost-sharing formula.

Code of Federal Regulations, 2010 CFR

2010-10-01

... control equipment; engineering costs (design/path survey); installation; systems testing; FCC filing costs; site acquisition and civil works; zoning costs; training; disposal of old equipment; test equipment... a replacement system, such as equipment and engineering expenses. C may not exceed $250,000 per...

Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering.

PubMed

Nuñez, James K; Harrington, Lucas B; Doudna, Jennifer A

2016-03-18

The application of the CRISPR-Cas9 system for genome engineering has revolutionized the ability to interrogate genomes of mammalian cells. Programming the Cas9 endonuclease to induce DNA breaks at specified sites is achieved by simply modifying the sequence of its cognate guide RNA. Although Cas9-mediated genome editing has been shown to be highly specific, cleavage events at off-target sites have also been reported. Minimizing, and eventually abolishing, unwanted off-target cleavage remains a major goal of the CRISPR-Cas9 technology before its implementation for therapeutic use. Recent efforts have turned to chemical biology and biophysical approaches to engineer inducible genome editing systems for controlling Cas9 activity at the transcriptional and protein levels. Here, we review recent advancements to modulate Cas9-mediated genome editing by engineering split-Cas9 constructs, inteins, small molecules, protein-based dimerizing domains, and light-inducible systems.

KSC-2012-6405

NASA Image and Video Library

2012-09-20

CAPE CANAVERAL, Fla. -- At NASA’s Kennedy Space Center in Florida, a groundbreaking was held to mark the start of construction on the Antenna Test Bed Array for the Ka-Band Objects Observation and Monitoring, or Ka-BOOM system. Using ceremonial shovels to mark the site, from left are Michael Le, lead design engineer and construction manager Sue Vingris, Cape Design Engineer Co. project manager Kannan Rengarajan, chief executive officer of Cape Design Engineer Co. Lutfi Mized, president of Cape Design Engineer Co. David Roelandt, construction site superintendent with Cape Design Engineer Co. Marc Seibert, NASA project manager Michael Miller, NASA project manager Peter Aragona, KSC’s Electromagnetic Lab manager Stacy Hopper, KSCs master planning supervisor Dr. Bary Geldzabler, NASA chief scientist and KSC’s Chief Technologist Karen Thompson. The construction site is near the former Vertical Processing Facility, which has been demolished. Workers will begin construction on the pile foundations for the 40-foot-diameter dish antenna arrays and their associated utilities, and prepare the site for the operations command center facility. Photo credit: NASA/Charisse Nahser

78 FR 6400 - Twenty Third Meeting: RTCA Special Committee 203, Unmanned Aircraft Systems

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

..., Washington, DC 20036, or by telephone at (202) 833- 9339, fax at (202) 833-9434, or Web site at http://www...-Morning/Afternoon Workgroup Breakout Sessions System Engineering Workgroup Human Factors Subgroup C&C... Breakout Sessions System Engineering Workgroup C&C Workgroup S&A Workgroup Safety Workgroup Friday...

Thermal power systems small power systems application project: Siting issues for solar thermal power plants with small community applications

NASA Technical Reports Server (NTRS)

Holbeck, H. J.; Ireland, S. J.

1979-01-01

The siting issues associated with small, dispersed solar thermal power plants for utility/small community applications of less than 10 MWe are reported. Some specific requirements are refered to the first engineering experiment for the Small Power Systems Applications (SPSA) Project. The background for the subsequent issue discussions is provided. The SPSA Project and the requirements for the first engineering experiment are described, and the objectives and scope for the report as a whole. A overview of solar thermal technologies and some technology options are discussed.

14. Site D57C, Improved NIKEHercules System, Grading Plan, U.S. Army ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Site D-57-C, Improved NIKE-Hercules System, Grading Plan, U.S. Army Corps of Engineers, 18 January 1962. - Newport NIKE Missile Battery D-57/58, Integrated Fire Control Area, Newport Road, Carleton, Monroe County, MI

Intelligent web image retrieval system

NASA Astrophysics Data System (ADS)

Hong, Sungyong; Lee, Chungwoo; Nah, Yunmook

2001-07-01

Recently, the web sites such as e-business sites and shopping mall sites deal with lots of image information. To find a specific image from these image sources, we usually use web search engines or image database engines which rely on keyword only retrievals or color based retrievals with limited search capabilities. This paper presents an intelligent web image retrieval system. We propose the system architecture, the texture and color based image classification and indexing techniques, and representation schemes of user usage patterns. The query can be given by providing keywords, by selecting one or more sample texture patterns, by assigning color values within positional color blocks, or by combining some or all of these factors. The system keeps track of user's preferences by generating user query logs and automatically add more search information to subsequent user queries. To show the usefulness of the proposed system, some experimental results showing recall and precision are also explained.

Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

PubMed Central

Kabadi, Ami M.; Ousterout, David G.; Hilton, Isaac B.; Gersbach, Charles A.

2014-01-01

Engineered DNA-binding proteins that manipulate the human genome and transcriptome have enabled rapid advances in biomedical research. In particular, the RNA-guided CRISPR/Cas9 system has recently been engineered to create site-specific double-strand breaks for genome editing or to direct targeted transcriptional regulation. A unique capability of the CRISPR/Cas9 system is multiplex genome engineering by delivering a single Cas9 enzyme and two or more single guide RNAs (sgRNAs) targeted to distinct genomic sites. This approach can be used to simultaneously create multiple DNA breaks or to target multiple transcriptional activators to a single promoter for synergistic enhancement of gene induction. To address the need for uniform and sustained delivery of multiplex CRISPR/Cas9-based genome engineering tools, we developed a single lentiviral system to express a Cas9 variant, a reporter gene and up to four sgRNAs from independent RNA polymerase III promoters that are incorporated into the vector by a convenient Golden Gate cloning method. Each sgRNA is efficiently expressed and can mediate multiplex gene editing and sustained transcriptional activation in immortalized and primary human cells. This delivery system will be significant to enabling the potential of CRISPR/Cas9-based multiplex genome engineering in diverse cell types. PMID:25122746

Creating Educational Opportunities for Engineers with Communication Technologies.

ERIC Educational Resources Information Center

Baldwin, Lionel V.

The large number and known career patterns of engineers make them an important target population for the use of videotechnology in programs of continuing professional education. Currently, universities use videobased instruction with engineering students on and off campus. A variety of signal delivery systems are used to link job sites to…

Fuel supply system and method for coal-fired prime mover

DOEpatents

Smith, William C.; Paulson, Leland E.

1995-01-01

A coal-fired gas turbine engine is provided with an on-site coal preparation and engine feeding arrangement. With this arrangement, relatively large dry particles of coal from an on-site coal supply are micro-pulverized and the resulting dry, micron-sized, coal particulates are conveyed by steam or air into the combustion chamber of the engine. Thermal energy introduced into the coal particulates during the micro-pulverizing step is substantially recovered since the so-heated coal particulates are fed directly from the micro-pulverizer into the combustion chamber.

Space Shuttle Main Engine Joint Data List Applying Today's Desktop Technologies to Facilitate Engine Processing

NASA Technical Reports Server (NTRS)

Jacobs, Kenneth; Drobnick, John; Krell, Don; Neuhart, Terry; McCool, A. (Technical Monitor)

2001-01-01

Boeing-Rocketdyne's Space Shuttle Main Engine (SSME) is the world's first large reusable liquid rocket engine. The space shuttle propulsion system has three SSMEs, each weighing 7,400 lbs and providing 470,000 lbs of thrust at 100% rated power level. To ensure required safety and reliability levels are achieved with the reusable engines, each SSME is partially disassembled, inspected, reassembled, and retested at Kennedy Space Center between each flight. Maintenance processing must be performed very carefully to replace any suspect components, maintain proper engine configuration, and avoid introduction of contaminants that could affect performance and safety. The long service life, and number, complexity, and pedigree of SSME components makes logistics functions extremely critical. One SSME logistics challenge is documenting the assembly and disassembly of the complex joint configurations. This data (joint nomenclature, seal and fastener identification and orientation, assembly sequence, fastener torques, etc.) must be available to technicians and engineers during processing. Various assembly drawings and procedures contain this information, but in this format the required (practical) joint data can be hard to find, due to the continued use of archaic engineering drawings and microfilm for field site use. Additionally, the release system must traverse 2,500 miles between design center and field site, across three time zones, which adds communication challenges and time lags for critical engine configuration data. To aid in information accessibility, a Joint Data List (JDL) was developed that allows efficient access to practical joint data. The published JDL has been a very useful logistics product, providing illustrations and information on the latest SSME configuration. The JDL identifies over 3,350 unique parts across seven fluid systems, over 300 joints, times two distinct engine configurations. The JDL system was recently converted to a web-based, navigable electronic manual that contains all the required data and illustrations in expanded view format using standard PC products (Word, Excel, PDF, Photoshop). The logistics of accurately releasing this information to field personnel was greatly enhanced via the utilization of common office products to produce a more user-friendly format than was originally developed under contract to NASA. This was done without reinventing the system, which would be cost prohibitive on a program of this maturity. The brunt of the joint part tracking is done within the logistics organization and disseminated to all field sites, without duplicating effort at each site. The JDL is easily accessible across the country via the NASA intranet directly at the SSME workstand. The advent of this logistics data product has greatly enhanced the reliability of tracking dynamic changes to the SSME and greatly reduces engineering change turnaround time and potential for errors. Since the inception of the JDL system in 1997, no discrepant parts have propagated to engine assembly operations. This presentation focuses on the challenges overcome and the techniques used to apply today's desktop technologies to an existing logistics data source.

Remediation System Evaluation, Vineland Chemical Company Superfund Site, Vineland, New Jersey

EPA Pesticide Factsheets

The Vineland Chemical Company Superfund Site was selected by EPA OSRTI based on recommendations from the EPA Remedial Project Manager for the site and from the U.S. Army Corps of Engineers (USACE) Philadelphia District that provides oversight of remedial..

Simultaneous non-contiguous deletions using large synthetic DNA and site-specific recombinases

PubMed Central

Krishnakumar, Radha; Grose, Carissa; Haft, Daniel H.; Zaveri, Jayshree; Alperovich, Nina; Gibson, Daniel G.; Merryman, Chuck; Glass, John I.

2014-01-01

Toward achieving rapid and large scale genome modification directly in a target organism, we have developed a new genome engineering strategy that uses a combination of bioinformatics aided design, large synthetic DNA and site-specific recombinases. Using Cre recombinase we swapped a target 126-kb segment of the Escherichia coli genome with a 72-kb synthetic DNA cassette, thereby effectively eliminating over 54 kb of genomic DNA from three non-contiguous regions in a single recombination event. We observed complete replacement of the native sequence with the modified synthetic sequence through the action of the Cre recombinase and no competition from homologous recombination. Because of the versatility and high-efficiency of the Cre-lox system, this method can be used in any organism where this system is functional as well as adapted to use with other highly precise genome engineering systems. Compared to present-day iterative approaches in genome engineering, we anticipate this method will greatly speed up the creation of reduced, modularized and optimized genomes through the integration of deletion analyses data, transcriptomics, synthetic biology and site-specific recombination. PMID:24914053

Opportunities for Launch Site Integrated System Health Engineering and Management

NASA Technical Reports Server (NTRS)

Waterman, Robert D.; Langwost, Patricia E.; Waterman, Susan J.

2005-01-01

The launch site processing flow involves operations such as functional verification, preflight servicing and launch. These operations often include hazards that must be controlled to protect human life and critical space hardware assets. Existing command and control capabilities are limited to simple limit checking durig automated monitoring. Contingency actions are highly dependent on human recognition, decision making, and execution. Many opportunities for Integrated System Health Engineering and Management (ISHEM) exist throughout the processing flow. This paper will present the current human-centered approach to health management as performed today for the shuttle and space station programs. In addition, it will address some of the more critical ISHEM needs, and provide recommendations for future implementation of ISHEM at the launch site.

KSC-2012-6404

NASA Image and Video Library

2012-09-20

CAPE CANAVERAL, Fla. -- At NASA’s Kennedy Space Center in Florida, a groundbreaking was held to mark the start of construction on the Antenna Test Bed Array for the Ka-Band Objects Observation and Monitoring, or Ka-BOOM system. Holding ceremonial shovels, from left are Michael Le, lead design engineer and construction manager Sue Vingris, Cape Design Engineer Co. project manager Kannan Rengarajan, chief executive officer of Cape Design Engineer Co. Lutfi Mized, president of Cape Design Engineer Co. David Roelandt, construction site superintendent with Cape Design Engineer Co. Marc Seibert, NASA project manager Michael Miller, NASA project manager Peter Aragona, KSC’s Electromagnetic Lab manager Stacy Hopper, KSCs master planning supervisor Dr. Bary Geldzabler, NASA chief scientist and KSC’s Chief Technologist Karen Thompson. The construction site is near the former Vertical Processing Facility, which has been demolished. Workers will begin construction on the pile foundations for the 40-foot-diameter dish antenna arrays and their associated utilities, and prepare the site for the operations command center facility. Photo credit: NASA/Charisse Nahser

Celebrating 50 Years of Testing

NASA Image and Video Library

2016-04-19

What better way to mark 50 years of rocket engine testing than with a rocket engine test? Stennis Space Center employees enjoyed a chance to view an RS-68 engine test at the B-1 Test Stand on April 19, almost 50 years to the day that the first test was conducted at the south Mississippi site in 1966. The test viewing was part of a weeklong celebration of the 50th year of rocket engine testing at Stennis. The first test at the site occurred April 23, 1966, with a 15-second firing of a Saturn V second stage prototype (S-II-C) on the A-2 Test Stand. The center subsequently tested Apollo rocket stages that carried humans to the moon and every main engine used to power 135 space shuttle missions. It currently tests engines for NASA’s new Space Launch System vehicle.

FLP recombinase-mediated site-specific recombination in silkworm, Bombyx mori

USDA-ARS?s Scientific Manuscript database

A comprehensive understanding of gene function and the production of site-specific genetically modified mutants are two major goals of genetic engineering in the post-genomic era. Although site-specific recombination systems have been powerful tools for genome manipulation of many organisms, they h...

Hire a Milwaukee Engineer | College of Engineering & Applied Science

Science.gov Websites

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z D2L PAWS Email My UW-System About UWM UWM Jobs D2L PAWS Email My UW-System University of Wisconsin-Milwaukee College ofEngineering & Olympiad Girls Who Code Club FIRST Tech Challenge NSF I-Corps Site of Southeastern Wisconsin UW-Milwaukee

April 2016 Milwaukee Engineer | College of Engineering & Applied Science

Science.gov Websites

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z D2L PAWS Email My UW-System About UWM UWM Jobs D2L PAWS Email My UW-System University of Wisconsin-Milwaukee College ofEngineering & Olympiad Girls Who Code Club FIRST Tech Challenge NSF I-Corps Site of Southeastern Wisconsin UW-Milwaukee

47 CFR 101.103 - Frequency coordination procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... requirements of § 101.21(f). In engineering a system or modification thereto, the applicant must, by....2-12.7 GHz frequency band and maintain an Internet web site of all existing transmitting sites and...

47 CFR 101.103 - Frequency coordination procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... requirements of § 101.21(f). In engineering a system or modification thereto, the applicant must, by....2-12.7 GHz frequency band and maintain an Internet web site of all existing transmitting sites and...

GIS least-cost analysis approach for siting gas pipeline ROWs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.; Wilkey, P.L.

1994-09-01

Geographic-information-system applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation corridors, endangered species habitats, wetlands, and public line surveys. A geographic information system was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas-pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

CADDIS Site Map

EPA Pesticide Factsheets

The Causal Analysis/Diagnosis Decision Information System, or CADDIS, is a website developed to help scientists and engineers in the Regions, States, and Tribes conduct causal assessments in aquatic systems.

DEMONSTRATION BULLETIN: SITE CHARACTERIZATION ANALYSIS PENETROMETER SYSTEM (SCAPS) LIF SENSOR - U.S. ARMY, NAVY, AND AIR FORCE (TRI-SERVICES)

EPA Science Inventory

The Tri-Services Site Characterization Analysis Penetrometer System (SCAPS) was developed by the U.S. Army (U.S. Army Corps of Engineers, Waterways Experiment Station [WES] and the Army Environmental Center [AEC]), Navy (Naval Command, Control and Ocean Surveillance Center), and ...

Research on Building Education & Workforce Capacity in Systems Engineering

DTIC Science & Technology

2011-02-07

manufacturing or design sites where students could observe engineering processes related to their projects Mentors with the highest level of student ... engagement interacted with students in every single activity area and with frequency, while others provided only intermittent correspondence. Note

Prototype solar heating and combined heating cooling systems

NASA Technical Reports Server (NTRS)

1978-01-01

The design and development of eight prototype solar heating and combined heating and cooling systems is discussed. The program management and systems engineering are reported, and operational test sites are identified.

Sodium heat engine system: Space application

NASA Astrophysics Data System (ADS)

Betz, Bryan H.; Sungu, Sabri; Vu, Hung V.

1994-08-01

This paper explores the possibility of utilizing the Sodium Heat Engine (SHE) or known as AMTEC (Alkali Metal Thermoelectric Converter), for electrical power generation in ``near earth'' geosynchronous orbit. The Sodium Heat Engine principle is very flexible and adapts well to a variety of physical geometries. The proposed system can be easily folded and then deployed into orbit without the need for on site assembly in space. Electric power generated from SHE engine can be used in communication satellites, in space station, and other applications such as electrical recharging of vehicles in space is one of the applications the Sodium Heat Engine could be adapted to serve.

Engineering Translational Activators with CRISPR-Cas System.

PubMed

Du, Pei; Miao, Chensi; Lou, Qiuli; Wang, Zefeng; Lou, Chunbo

2016-01-15

RNA parts often serve as critical components in genetic engineering. Here we report a design of translational activators which is composed of an RNA endoribonuclease (Csy4) and two exchangeable RNA modules. Csy4, a member of Cas endoribonuclease, cleaves at a specific recognition site; this cleavage releases a cis-repressive RNA module (crRNA) from the masked ribosome binding site (RBS), which subsequently allows the downstream translation initiation. Unlike small RNA as a translational activator, the endoribonuclease-based activator is able to efficiently unfold the perfect RBS-crRNA pairing. As an exchangeable module, the crRNA-RBS duplex was forwardly and reversely engineered to modulate the dynamic range of translational activity. We further showed that Csy4 and its recognition site, together as a module, can also be replaced by orthogonal endoribonuclease-recognition site homologues. These modularly structured, high-performance translational activators would endow the programming of gene expression in the translation level with higher feasibility.

7 CFR 1726.404 - Non-site specific construction contract closeout.

Code of Federal Regulations, 2014 CFR

2014-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract... equipment is supplied under a construction contract, the borrower (acting through its engineer, if... equipment. The borrower (acting through its engineer, if applicable) will schedule such inspection and...

7 CFR 1726.404 - Non-site specific construction contract closeout.

Code of Federal Regulations, 2010 CFR

2010-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract... equipment is supplied under a construction contract, the borrower (acting through its engineer, if... equipment. The borrower (acting through its engineer, if applicable) will schedule such inspection and...

7 CFR 1726.404 - Non-site specific construction contract closeout.

Code of Federal Regulations, 2011 CFR

2011-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract... equipment is supplied under a construction contract, the borrower (acting through its engineer, if... equipment. The borrower (acting through its engineer, if applicable) will schedule such inspection and...

7 CFR 1726.404 - Non-site specific construction contract closeout.

Code of Federal Regulations, 2012 CFR

2012-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract... equipment is supplied under a construction contract, the borrower (acting through its engineer, if... equipment. The borrower (acting through its engineer, if applicable) will schedule such inspection and...

7 CFR 1726.404 - Non-site specific construction contract closeout.

Code of Federal Regulations, 2013 CFR

2013-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract... equipment is supplied under a construction contract, the borrower (acting through its engineer, if... equipment. The borrower (acting through its engineer, if applicable) will schedule such inspection and...

In vivo modification of a maize engineered minichromosome.

PubMed

Gaeta, Robert T; Masonbrink, Rick E; Zhao, Changzeng; Sanyal, Abhijit; Krishnaswamy, Lakshminarasimhan; Birchler, James A

2013-06-01

Engineered minichromosomes provide efficient platforms for stacking transgenes in crop plants. Methods for modifying these chromosomes in vivo are essential for the development of customizable systems for the removal of selection genes or other sequences and for the addition of new genes. Previous studies have demonstrated that Cre, a site-specific recombinase, could be used to modify lox sites on transgenes on maize minichromosomes; however, these studies demonstrated somatic recombination only, and modified minichromosomes could not be recovered. We describe the recovery of an engineered chromosome composed of little more than a centromere plus transgene that was derived by telomere-mediated truncation. We used the fiber fluorescence in situ hybridization technique and detected a transgene on the minichromosome inserted among stretches of CentC centromere repeats, and this insertion was large enough to suggest a tandem insertion. By crossing the minichromosome to a plant expressing Cre-recombinase, the Bar selection gene was removed, leaving behind a single loxP site. This study demonstrates that engineered chromosomes can be modified in vivo using site-specific recombinases, a demonstration essential to the development of amendable chromosome platforms in plants.

Modeling Groundwater Flow and Infiltration at Potential Low-Level Radioactive Waste Disposal Sites in Taiwan

NASA Astrophysics Data System (ADS)

Arnold, B. W.; Lee, C.; Ma, C.; Knowlton, R. G.

2006-12-01

Taiwan is evaluating representative sites for the potential disposal of low-level radioactive waste (LLW), including consideration of shallow land burial and cavern disposal concepts. A representative site for shallow land burial is on a small island in the Taiwan Strait with basalt bedrock. The shallow land burial concept includes an engineered cover to limit infiltration into the waste disposal cell. A representative site for cavern disposal is located on the southeast coast of Taiwan. The tunnel system for this disposal concept would be several hundred meters below the mountainous land surface in argillite bedrock. The LLW will consist of about 966,000 drums, primarily from the operation and decommissioning of four nuclear power plants. Sandia National Laboratories and the Institute of Nuclear Energy Research have collaborated to develop performance assessment models to evaluate the long-term safety of LLW disposal at these representative sites. Important components of the system models are sub-models of groundwater flow in the natural system and infiltration through the engineered cover for the shallow land burial concept. The FEHM software code was used to simulate groundwater flow in three-dimensional models at both sites. In addition, a higher-resolution two-dimensional model was developed to simulate flow through the engineered tunnel system at the cavern site. The HELP software was used to simulate infiltration through the cover at the island site. The primary objective of these preliminary models is to provide a modeling framework, given the lack of site-specific data and detailed engineering design specifications. The steady-state groundwater flow model at the island site uses a specified recharge boundary at the land surface and specified head at the island shoreline. Simulated groundwater flow vectors are extracted from the FEHM model along a cross section through one of the LLW disposal cells for utilization in radionuclide transport simulations in the performance assessment model with the BLT-MS software. Infiltration through the engineered cover is simulated to be about 3 mm/yr and 49 mm/yr, with and without a geomembrane layer, respectively. For the cavern LLW disposal site, the FEHM basin-scale flow model uses specified recharge flux, constant head at the ocean shoreline, and head-dependent flux boundaries along flowing streams. Groundwater flow vectors are extracted along a cross section for use in radionuclide transport simulations. Transport simulations indicate that a significant fraction of contaminants may ultimately discharge to nearby streams. FEHM flow simulations with the drift-scale model indicate that the flow rates within the backfilled tunnels may be more than two orders of magnitude lower than in the host rock. Sandia National Laboratories is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-AC04-94AL85000.

An Experimental Remote Question-Answer Scan Television and Student Evaluation System.

ERIC Educational Resources Information Center

Rigas, Anthony L.

Presented is a description of the development and use of a technical system designed to provide students (in this case, engineering students) situated at remote sites a means for better interaction with their instructors. For example, students at such sites cannot get their immediate questions answered because of the physical location of their…

Life-Cycle Cost Database. Volume II. Appendices E, F, and G. Sample Data Development.

DTIC Science & Technology

1983-01-01

Bendix Field Engineering Corporation Columbia, Maryland 21045 5 CONTENTS Page GENERAL 8 Introduction Objective Engineering Survey SYSTEM DESCRIPTION...in a typical administrative type building over a 25-year period. 1.3 ENGINEERING SURVEY An on-site survey was conducted by Bendix Field Engineering...Damp Mop and Buff Buff Routine Vacuum Strip and Refinish Heavy Duty Vacuum Machine, Scrub and Surface Shampoo Pick Up Extraction Clean Repair Location

49 CFR 238.203 - Static end strength.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., sufficient to describe the actual construction of the equipment; (iii) Engineering analysis sufficient to..., engineering analysis, and risk mitigation measures described in this paragraph, demonstrating that the use of... the Federal Docket Management System and posted on its web site at http://www.regulations.gov. (h...

49 CFR 238.203 - Static end strength.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., sufficient to describe the actual construction of the equipment; (iii) Engineering analysis sufficient to..., engineering analysis, and risk mitigation measures described in this paragraph, demonstrating that the use of... the Federal Docket Management System and posted on its web site at http://www.regulations.gov. (h...

15. SITE BUILDING 004 ELECTRIC POWER STATION VIEW ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. SITE BUILDING 004 - ELECTRIC POWER STATION - VIEW IS LOOKING SOUTH 55° EAST AT FIVE DIESEL ENGINE/ GENERATOR SILENCER SYSTEM EXHAUST STACKS. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

Collection, processing and dissemination of data for the national solar demonstration program

NASA Technical Reports Server (NTRS)

Day, R. E.; Murphy, L. J.; Smok, J. T.

1978-01-01

A national solar data system developed for the DOE by IBM provides for automatic gathering, conversion, transfer, and analysis of demonstration site data. NASA requirements for this system include providing solar site hardware, engineering, data collection, and analysis. The specific tasks include: (1) solar energy system design/integration; (2) developing a site data acquisition subsystem; (3) developing a central data processing system; (4) operating the test facility at Marshall Space Flight Center; (5) collecting and analyzing data. The systematic analysis and evaluation of the data from the National Solar Data System is reflected in a monthly performance report and a solar energy system performance evaluation report.

47 CFR 27.1180 - The cost-sharing formula.

Code of Federal Regulations, 2010 CFR

2010-10-01

...); towers and/or modifications; back-up power equipment; monitoring or control equipment; engineering costs (design/path survey); installation; systems testing; FCC filing costs; site acquisition and civil works... as equipment and engineering expenses. There is no cap on the actual costs of relocation. (c) An AWS...

Light-Inducible Gene Regulation with Engineered Zinc Finger Proteins

PubMed Central

Polstein, Lauren R.; Gersbach, Charles A.

2014-01-01

The coupling of light-inducible protein-protein interactions with gene regulation systems has enabled the control of gene expression with light. In particular, heterodimer protein pairs from plants can be used to engineer a gene regulation system in mammalian cells that is reversible, repeatable, tunable, controllable in a spatiotemporal manner, and targetable to any DNA sequence. This system, Light-Inducible Transcription using Engineered Zinc finger proteins (LITEZ), is based on the blue light-induced interaction of GIGANTEA and the LOV domain of FKF1 that drives the localization of a transcriptional activator to the DNA-binding site of a highly customizable engineered zinc finger protein. This chapter provides methods for modifying LITEZ to target new DNA sequences, engineering a programmable LED array to illuminate cell cultures, and using the modified LITEZ system to achieve spatiotemporal control of transgene expression in mammalian cells. PMID:24718797

ROBOTICS IN HAZARDOUS ENVIRONMENTS - REAL DEPLOYMENTS BY THE SAVANNAH RIVER NATIONAL LABORATORY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kriikku, E.; Tibrea, S.; Nance, T.

The Research & Development Engineering (R&DE) section in the Savannah River National Laboratory (SRNL) engineers, integrates, tests, and supports deployment of custom robotics, systems, and tools for use in radioactive, hazardous, or inaccessible environments. Mechanical and electrical engineers, computer control professionals, specialists, machinists, welders, electricians, and mechanics adapt and integrate commercially available technology with in-house designs, to meet the needs of Savannah River Site (SRS), Department of Energy (DOE), and other governmental agency customers. This paper discusses five R&DE robotic and remote system projects.

Assessment of Uinta Basin Oil and Natural Gas Well Pad ...

EPA Pesticide Factsheets

In the fall of 2016, a field study was conducted in the Uinta Basin Utah to improve information on oil and natural gas well pad pneumatic controllers (PCs) and emission measurement methods. A total of 80 PC systems at five oil sites (supporting six wells) and three gas sites (supporting 12 wells) were surveyed, and emissions data were produced using a combination of measurements and engineering emission estimates. Ninety-six percent of the PCs surveyed were the low actuation frequency intermittent vent type. The overall whole gas emission rate for the study was estimated at 0.37 scfh with the majority of emissions occurring from three continuous vent PCs (1.0 scfh average) and eleven (14%) malfunctioning intermittent vent PC systems (1.6 scfh average). Oil sites employed, on average 10.3 PC systems per well compared to 1.5 for gas sites. Oil and gas sites had group average PC emission rates of 0.28 scfh and 0.67 scfh, respectively, with this difference due in part to site selection procedures. The PC system types encountered, the engineering emissions estimate approach, and comparisons to measurements are described. Survey methods included identification of malfunctioning PC systems and emission measurements with augmented high volume sampling and installed mass flow meters, each providing a somewhat different picture of emissions that are elucidated through example cases. This paper reports on an oil and natural gas well pad pneumatic controller emissions stud

Conditional Toxin Splicing Using a Split Intein System.

PubMed

Alford, Spencer C; O'Sullivan, Connor; Howard, Perry L

2017-01-01

Protein toxin splicing mediated by split inteins can be used as a strategy for conditional cell ablation. The approach requires artificial fragmentation of a potent protein toxin and tethering each toxin fragment to a split intein fragment. The toxin-intein fragments are, in turn, fused to dimerization domains, such that addition of a dimerizing agent reconstitutes the split intein. These chimeric toxin-intein fusions remain nontoxic until the dimerizer is added, resulting in activation of intein splicing and ligation of toxin fragments to form an active toxin. Considerations for the engineering and implementation of conditional toxin splicing (CTS) systems include: choice of toxin split site, split site (extein) chemistry, and temperature sensitivity. The following method outlines design criteria and implementation notes for CTS using a previously engineered system for splicing a toxin called sarcin, as well as for developing alternative CTS systems.

Ancient engineering geology projects in China; A canal system in Ganzu province and trenches along the Great Wall in Ningxia Hui Autonomous Region

USGS Publications Warehouse

Wallace, R.E.; Bucknam, R.C.; Hanks, T.C.

1994-01-01

Two major construction projects of ancient times in China involved what today would be considered engineering geology. We describe an ancient canal system in Gaotai County, Gansu province that was possibly begun in the Han dynasty (206 BC-220 AD). The canal system heads at the Dasha River and extends northwestward for about 55 km to the City of Camels and Xusanwan village. Four parallel canals are present at the local site we examined. The canals were likely built primarily to transport water but may also have served as defensive military barriers. A second project involves trenches and berms along the north side of the Great Wall, clearly part of the Great Wall defensive system. This site is in Ningxia Autonomous Region near the town of Shizuishan. ?? 1994.

168. Photocopy of drawing (1979 civil engineering drawing by the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

168. Photocopy of drawing (1979 civil engineering drawing by the Space and Missile Test Center, USAF) NITROGEN AND HELIUM PUMPING SYSTEM INSTALLATION SITE PLAN, SHEET 511-C-1 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Engineering for Deep Sea Drilling for Scientific Purposes

DTIC Science & Technology

1980-01-01

Clyde Consultants JOSEPH E. BEALL, Triton Engineering Services Company DOUWE DE VRIES, N L Industries, Incorporated TERRY N. GARDNER, Exxon...estimate: $1 million additional cost for each site drilled and 25 to 35 wells to be drilled over the period. __ U 20 inclusion in a request for proposal...26 of a positively buoyant system would allow a nearly conventional rise tensioning system. However, the latter approach would require de - .aping a

Integrated medical and behavioral laboratory measurement system engineering analysis and laboratory specification

NASA Technical Reports Server (NTRS)

Grave, C.; Margold, D. W.

1973-01-01

Site selection, program planning, cost and design studies for support of the IMBLMS program were investigated. Accomplishments are reported for the following areas: analysis of responses to site selection criteria, space-oriented biotechnology, life sciences payload definition, and program information transfer.

Mission analysis report for single-shell tank leakage mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cruse, J.M.

1994-09-01

This document provides an analysis of the leakage mitigation mission applicable to past and potential future leakage from the Hanford Site`s 149 single-shell high-level waste tanks. This mission is a part of the overall missions of the Westinghouse Hanford Company Tank Waste Remediation System division to remediate the tank waste in a safe and acceptable manner. Systems engineers principles are being applied to this effort. Mission analysis supports early decision making by clearly defining program objectives. This documents identifies the initial conditions and acceptable final conditions, defines the programmatic and physical interfaces and constraints, estimates the resources to carry outmore » the mission, and establishes measures of success. The results of the mission analysis provide a consistent basis for subsequent systems engineering work.« less

Magnetohydrodynamics (MHD) Engineering Test Facility (ETF) 200 MWe power plant. Conceptual Design Engineering Report (CDER). Volume 2: Engineering. Volume 3: Costs and schedules

NASA Astrophysics Data System (ADS)

1981-09-01

Engineering design details for the principal systems, system operating modes, site facilities, and structures of an engineering test facility (ETF) of a 200 MWE power plant are presented. The ETF resembles a coal-fired steam power plant in many ways. It is analogous to a conventional plant which has had the coal combustor replaced with the MHD power train. Most of the ETF components are conventional. They can, however, be sized or configured differently or perform additional functions from those in a conventional coal power plant. The boiler not only generates steam, but also performs the functions of heating the MHD oxidant, recovering seed, and controlling emissions.

Magnetohydrodynamics (MHD) Engineering Test Facility (ETF) 200 MWe power plant. Conceptual Design Engineering Report (CDER). Volume 2: Engineering. Volume 3: Costs and schedules

NASA Technical Reports Server (NTRS)

1981-01-01

Engineering design details for the principal systems, system operating modes, site facilities, and structures of an engineering test facility (ETF) of a 200 MWE power plant are presented. The ETF resembles a coal-fired steam power plant in many ways. It is analogous to a conventional plant which has had the coal combustor replaced with the MHD power train. Most of the ETF components are conventional. They can, however, be sized or configured differently or perform additional functions from those in a conventional coal power plant. The boiler not only generates steam, but also performs the functions of heating the MHD oxidant, recovering seed, and controlling emissions.

Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins.

PubMed

Gan, Rui; Perez, Jessica G; Carlson, Erik D; Ntai, Ioanna; Isaacs, Farren J; Kelleher, Neil L; Jewett, Michael C

2017-05-01

The ability to site-specifically incorporate non-canonical amino acids (ncAAs) into proteins has made possible the study of protein structure and function in fundamentally new ways, as well as the bio synthesis of unnatural polymers. However, the task of site-specifically incorporating multiple ncAAs into proteins with high purity and yield continues to present a challenge. At the heart of this challenge lies the lower efficiency of engineered orthogonal translation system components compared to their natural counterparts (e.g., translation elements that specifically use a ncAA and do not interact with the cell's natural translation apparatus). Here, we show that evolving and tuning expression levels of multiple components of an engineered translation system together as a whole enhances ncAA incorporation efficiency. Specifically, we increase protein yield when incorporating multiple p-azido-phenylalanine(pAzF) residues into proteins by (i) evolving the Methanocaldococcus jannaschii p-azido-phenylalanyl-tRNA synthetase anti-codon binding domain, (ii) evolving the elongation factor Tu amino acid-binding pocket, and (iii) tuning the expression of evolved translation machinery components in a single vector. Use of the evolved translation machinery in a genomically recoded organism lacking release factor one enabled enhanced multi-site ncAA incorporation into proteins. We anticipate that our approach to orthogonal translation system development will accelerate and expand our ability to site-specifically incorporate multiple ncAAs into proteins and biopolymers, advancing new horizons for synthetic and chemical biotechnology. Biotechnol. Bioeng. 2017;114: 1074-1086. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Comparison of fuel-cell and diesel integrated energy systems and a conventional system for a 500-unit apartment

NASA Technical Reports Server (NTRS)

Simons, S. N.; Maag, W. L.

1978-01-01

The electrical and thermal energy utilization efficiencies of a 500 unit apartment complex are analyzed and compared for each of three energy supply systems. Two on-site integrated energy systems, one powered by diesel engines and the other by phosphoric-acid fuel cells were compared with a conventional system which uses purchased electricity and on-site boilers for heating. All fuels consumed on-site are clean, synthetic fuels (distillate fuel oil or pipeline quality gas) derived from coal. Purchased electricity was generated from coal at a central station utility. The relative energy consumption and economics of the three systems are analyzed and compared.

Modeling the Hydrogeochemical Transport of Radionuclides through Engineered Barriers System in the Proposed LLW Disposal Site of Taiwan - 12082

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Wen-Sheng; Liu, Chen-Wuing; Tsao, Jui-Hsuan

2012-07-01

A proposed site for final disposal of low-level radioactive waste located in Daren Township of Taitung County along the southeastern coast has been on the selected list in Taiwan. The geology of the Daren site consists of argillite and meta-sedimentary rocks. A mined cavern design with a tunnel system of 500 m below the surface is proposed. Concrete is used as the main confinement material for the engineered barrier. To investigate the hydrogeochemical transport of radionuclides through engineered barriers system, HYDROGEOCHEM5.0 model was applied to simulate the complex chemical interactions among radionuclides, the cement minerals of the concrete, groundwater flow,more » and transport in the proposed site. The simulation results showed that the engineered barriers system with the side ditch efficiently drained the ground water and lowered the concentration of the concrete degradation induced species (e.g., hydrogen ion, sulfate, and chloride). The velocity of groundwater observed at side ditch gradually decreased with time due to the fouling of pore space by the mineral formation of ettringite and thaumasite. The short half-life of Co-60, Sr-90 and Cs-137 significantly reduced the concentrations, whereas the long half-life of I-129(1.57x10{sup 7} years) and Am-241(432 years) remain stable concentrations at the interface of waste canister and concrete barrier after 300 years. The mineral saturation index (SI) was much less than zero due to the low aqueous concentration of radionuclide, so that the precipitation formation of Co-60, Sr-90, I-129, Cs-137 and Am-241 related minerals were not found. The effect of adsorption/desorption (i.e., surface complexation model) could be a crucial geochemical mechanism for the modeling of liquid-solid phase behavior of radionuclide in geochemically dynamic environments. Moreover, the development of advanced numerical models that are coupled with hydrogeochemical transport and dose assessment of radionuclide is required in the future. (authors)« less

Pedestrian safety engineering and intelligent transportation system-based countermeasures program for reduced pedestrian fatalities, injuries, conflicts and other surrogate measures : Miami-Dade site.

DOT National Transportation Integrated Search

2008-08-25

This report presents the methods and key findings from the Miami-Dade comprehensive pedestrian safety planning and engineering project. It is one of three such projects in the nation funded by the Federal Highway Administration (FHWA) to evaluate: In...

GeoSearcher: Location-Based Ranking of Search Engine Results.

ERIC Educational Resources Information Center

Watters, Carolyn; Amoudi, Ghada

2003-01-01

Discussion of Web queries with geospatial dimensions focuses on an algorithm that assigns location coordinates dynamically to Web sites based on the URL. Describes a prototype search system that uses the algorithm to re-rank search engine results for queries with a geospatial dimension, thus providing an alternative ranking order for search engine…

Donate | College of Engineering & Applied Science

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About | College of Engineering & Applied Science

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College of Engineering & Applied Science

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75 FR 26321 - Seventeenth Plenary Meeting: RTCA Special Committee 203: Unmanned Aircraft Systems

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... RTCA Workspace Web Tool Special Committee Status Overview Workgroup Updates WG1--Systems Engineering..., Washington, DC 20036; telephone (202) 833-9339; fax (202) 833-9434; Web site http://www.rtca.org...

Siting Issues for Solar Thermal Power Plants with Small Community Applications

NASA Technical Reports Server (NTRS)

Holbeck, J. J.; Ireland, S. J.

1978-01-01

Technologies for solar thermal plants are being developed to provide energy alternatives for the future. Implementation of these plants requires consideration of siting issues as well as power system technology. While many conventional siting considerations are applicable, there is also a set of unique siting issues for solar thermal plants. Early experimental plants will have special siting considerations. The siting issues associated with small, dispersed solar thermal power plants in the 1 to 10 MWe power range for utility/small community applications are considered. Some specific requirements refer to the first 1 MWe engineering experiment for the Small Power Systems Applications (SPSA) Project. The siting issues themselves are discussed in three categories: (1) system resource requirements, (2) environmental effects on the system, and (3) potential impact of the plant on the environment. Within these categories, specific issues are discussed in a qualitative manner. Examples of limiting factors for some issues are taken from studies of other solar systems.

Exploiting Expertise and Knowledge Sharing Online for the Benefit of NASA's GN&C Community of Practice

NASA Technical Reports Server (NTRS)

Topousis, Daria E.; Lebsock, Kenneth L.; Dennehy, Cornelius J.

2010-01-01

In 2004, NASA faced major knowledge sharing challenges due to geographically isolated field centers that inhibited engineers from sharing their experiences, expertise, ideas, and lessons learned. The necessity to collaborate on complex development projects and the reality of constrained project resources together drove the need for ensuring that personnel at all NASA centers had comparable skill sets and that engineers could find resources in a timely fashion. Mission failures and new directions for the Agency also demanded better collaborative tools for NASA's engineering workforce. In response to these needs, the online NASA Engineering Network (NEN) was formed by the NASA Office of the Chief Engineer to provide a multi-faceted system for overcoming geographic and cultural barriers. NEN integrates communities of practice with a cross-repository search and the Lessons Learned Information System. This paper describes the features of the GN&C engineering discipline CoP site which went live on NEN in May of 2008 as an online means of gathering input and guidance from practitioners. It allows GN&C discipline expertise captured at one field center to be shared in a collaborative way with the larger discipline CoP spread across the entire Agency. The site enables GN&C engineers to find the information they need quickly, to find solutions to questions from experienced engineers, and to connect with other practitioners regardless of geographic location, thus increasing the probability of project success.

78 FR 8108 - NextGen Solutions Vendors Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... Commerce is developing a web-based NextGen Solutions Vendors Guide intended to be used by foreign air... being listed on the Vendors Guide Web site should submit their company's name, Web site address, contact... to aviation system upgrades) Example: Engineering Services More information on the four ICAO ASBU...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Office of Civilian Radioactive Waste Management Systems Engineering Management Plan (OCRWM SEMP) specifies the technical management approach for the development of the waste management system, and specifies the approach for the development of each of the system elements -- the waste acceptance system, the transportation system, the Monitored Retrievable Storage (MRS) facility, and the mined geologic disposal system, which includes site characterization activity. The SEMP also delineates how systems engineering will be used by OCRWM to describe the system development process; it identifies responsibilities for its implementation, and specifies the minimum requirements for systems engineering. It also identifies themore » close interrelationship of system engineering and licensing processes. This SEMP, which is a combined OCRWM and M&O SEMP, is part of the top-level program documentation and is prepared in accordance with the direction provided in the Program Management System Manual (PMSM). The relationship of this document to other top level documents in the CRWMS document hierarchy is defined in the PMSM. A systems engineering management plan for each project, which specifies the actions to be taken in implementing systems engineering at the project level, shall be prepared by the respective project managers. [``Program`` refers to the CRWMS-wide activity and ``project`` refers to that level responsible for accomplishing the specific activities of that segment of the program.] The requirements for the project level SEMPs are addressed in Section 4.2.2.2. They represent the minimum set of requirements, and do not preclude the broadening of systems engineering activities to meet the specific needs of each project.« less

Annual Systems Engineering Conference (12th). Volume 1

DTIC Science & Technology

2009-10-29

extended systems have sustainability challenges, e.g.: – Internet applications subject to: overload, environmental disturbance, virus downtime...Sites in MD, DC, VA MHPCC PMRF: Bldg 105 Sites in Hawaii Camp Pendleton: MCTSSA China Lake (2): AV-8B, F/A-18 IBAR Edwards: Ridley Corona : NSWC El...Air Platform Integration 3 Approved for Public Release; Distribution is unlimited. NSWC Carderock West Bethesda, MD NSWC Corona Norco, CA NSWC Crane

Two-stage earth-to-orbit vehicles with dual-fuel propulsion in the Orbiter

NASA Technical Reports Server (NTRS)

Martin, J. A.

1982-01-01

Earth-to-orbit vehicle studies of future replacements for the Space Shuttle are needed to guide technology development. Previous studies that have examined single-stage vehicles have shown advantages for dual-fuel propulsion. Previous two-stage system studies have assumed all-hydrogen fuel for the Orbiters. The present study examined dual-fuel Orbiters and found that the system dry mass could be reduced with this concept. The possibility of staging the booster at a staging velocity low enough to allow coast-back to the launch site is shown to be beneficial, particularly in combination with a dual-fuel Orbiter. An engine evaluation indicated the same ranking of engines as did a previous single-stage study. Propane and RP-1 fuels result in lower vehicle dry mass than methane, and staged-combustion engines are preferred over gas-generator engines. The sensitivity to the engine selection is less for two-stage systems than for single-stage systems.

Implications of the fluvial history of the Wacheqsa River for hydrologic engineering and water use at Chavín de Húntar, Peru

USGS Publications Warehouse

Contreras, Daniel A.; Keefer, David K.

2009-01-01

Channeling of water through a variety of architectural features represents a significant engineering investment at the first millennium B.C. ceremonial center of Chavín de Huántar in the Peruvian Central Andes. The site contains extensive evidence of the manipulation of water, apparently for diverse purposes. The present configuration of the two local rivers, however, keeps available water approximately 9m below the highest level of water-bearing infrastructure in the site. Geomorphic and archaeological investigation of the fluvial history of the Wacheqsa River has revealed evidence that the Chavín-era configuration of the Wacheqsa River was different. A substantially higher water level, likely the result of a local impoundment of river water caused by a landslide dam, made the provision of water for the hydrologic system within the site a more readily practical possibility. We review what is known of that system and argue that the fluvial history of the Wacheqsa River is critical to understanding this aspect of hydrologic engineering and ritual practice at Chavín. This study demonstrates the relative rapidity and archaeological relevance of landscape change in a dynamic environment.

Inspection of Construction Works According to Polish Construction Law

NASA Astrophysics Data System (ADS)

Czemplik, A.

2015-11-01

Construction regulations are still different in many European countries, even though the European Union directives have unified many acts for construction works and construction products in the member countries. The scheme of the construction process presented in the paper could be valid for most countries, despite of detailed regulations of legal systems. The number of construction regulations to be followed in order to get the Construction Permit in Poland is rather big, so the time between the start of the investment process and the day when the Construction Permit is issued could be several months. Only licensed professional engineers can play the role of site managers, site inspectors and designers, registered for the given construction project. Duties and responsibilities (civil liability) of these engineers are strictly defined by regulations. The obligatory inspection of construction works should be executed by the licensed site inspectors. Moreover, the works can be incidentally inspected by Authority, banks, insurance companies or designers. Foreign designers and foreign site engineers in order to be allowed by respective Authority to play official roles on Polish construction sites should present documents proving that they can do the same jobs in their countries as per regulations obligatory there.

Research Collaborations | College of Engineering & Applied Science

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Student Organizations | College of Engineering & Applied Science

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Incoming Freshman | College of Engineering & Applied Science

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Travel Directions | College of Engineering & Applied Science

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Future Students | College of Engineering & Applied Science

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Corporate Partners | College of Engineering & Applied Science

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EnQuest | College of Engineering & Applied Science

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Computer Resources | College of Engineering & Applied Science

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Strategic Planning | College of Engineering & Applied Science

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ANSYS Institute | College of Engineering & Applied Science

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Career Fairs | College of Engineering & Applied Science

Science.gov Websites

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Current Students | College of Engineering & Applied Science

Science.gov Websites

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Undergraduate Curriculum | College of Engineering & Applied Science

Science.gov Websites

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Research Centers & Consortia | College of Engineering & Applied Science

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Admissions - Graduate Students | College of Engineering & Applied Science

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FTC General Information | College of Engineering & Applied Science

Science.gov Websites

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Catalyst Grants: Sensing the Future | College of Engineering & Applied

Science.gov Websites

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Corporate Services | College of Engineering & Applied Science

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Computer Labs | College of Engineering & Applied Science

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Study Abroad | College of Engineering & Applied Science

Science.gov Websites

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Structures Laboratory | College of Engineering & Applied Science

Science.gov Websites

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Multimedia Software Laboratory | College of Engineering & Applied Science

Science.gov Websites

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Center for Composite Materials | College of Engineering & Applied Science

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Girls Who Code Club | College of Engineering & Applied Science

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Admissions - Undergraduate Students | College of Engineering & Applied

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Graduate Curriculum | College of Engineering & Applied Science

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Research Labs | College of Engineering & Applied Science

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Product Realization | College of Engineering & Applied Science

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Fast Facts | College of Engineering & Applied Science

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Strategic Plan | College of Engineering & Applied Science

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College-Wide Support | College of Engineering & Applied Science

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50th Anniversary | College of Engineering & Applied Science

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FAQ's and Deadlines | College of Engineering & Applied Science

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Office of Research Support | College of Engineering & Applied Science

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Department Chairs and Staff | College of Engineering & Applied Science

Science.gov Websites

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Cyber Exercise Playbook

DTIC Science & Technology

2014-11-01

unclassified tools and techniques that can be shared with PNs, to include social engineering, spear phishing , fake web sites, physical access attempts, and...and instead rely on commercial services such as Yahoo or Google . Some nations have quite advanced cyber security practices, but may take vastly...unauthorized access to data/systems Inject external network scanning, email phishing , malicious website access, social engineering Sample

Photographic copy of site plan for proposed Test Stand "D" ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of site plan for proposed Test Stand "D" in 1958. The contemporary site plans of test stands "A," "B," and "C" are also visible, along with the interconnecting tunnel system. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering "Site Plan for Proposed Test Stand "D" - Edwards Test Station," drawing no. ESP/22-0, 14 November 1958 - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

Application of Electrical Resistivity Imaging for Engineering Site Investigation. A Case Study on Prospective Hospital Site, Varamin, Iran

NASA Astrophysics Data System (ADS)

Amini, Amin; Ramazi, Hamidreza

2016-12-01

The article addresses the application of electrical resistivity imaging for engineering site investigation in Pishva Hospital, Varamin, Iran. Some aqueduct shafts exist in the study area backfilled by loose materials. The goals of this study are to detect probable aqueduct tunnels and their depth, investigate filling quality in the shafts as well as connection(s) between them. Therefore, three profiles were surveyed by dipoledipole electrode array. Also, to investigate the potentially anomalous areas more accurately, five additional resistivity profiles were measured by a Combined Resistivity Sounding-Profiling array (CRSP). According to the results of 2-D inversion modelling, a main aqueduct tunnel was detected beneath the central part of the site. Finally, the resistivity pattern of the detected aqueduct system passing the investigated area was provided using the obtained results.

Reactor Operations Monitoring System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, M.M.

1989-01-01

The Reactor Operations Monitoring System (ROMS) is a VME based, parallel processor data acquisition and safety action system designed by the Equipment Engineering Section and Reactor Engineering Department of the Savannah River Site. The ROMS will be analyzing over 8 million signal samples per minute. Sixty-eight microprocessors are used in the ROMS in order to achieve a real-time data analysis. The ROMS is composed of multiple computer subsystems. Four redundant computer subsystems monitor 600 temperatures with 2400 thermocouples. Two computer subsystems share the monitoring of 600 reactor coolant flows. Additional computer subsystems are dedicated to monitoring 400 signals from assortedmore » process sensors. Data from these computer subsystems are transferred to two redundant process display computer subsystems which present process information to reactor operators and to reactor control computers. The ROMS is also designed to carry out safety functions based on its analysis of process data. The safety functions include initiating a reactor scram (shutdown), the injection of neutron poison, and the loadshed of selected equipment. A complete development Reactor Operations Monitoring System has been built. It is located in the Program Development Center at the Savannah River Site and is currently being used by the Reactor Engineering Department in software development. The Equipment Engineering Section is designing and fabricating the process interface hardware. Upon proof of hardware and design concept, orders will be placed for the final five systems located in the three reactor areas, the reactor training simulator, and the hardware maintenance center.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.; Wilkey, P.L.

1992-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.

1993-10-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for land use/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.; Wilkey, P.L.

1992-01-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Interactive Visualization of Parking Orbits Around the Moon: An X3D Application for a NASA Lunar Mission Study

NASA Technical Reports Server (NTRS)

Murphy, Douglas G.; Qu, Min; Salas, Andrea O.

2006-01-01

The NASA Integrated Modeling and Simulation (IM&S) project aims to develop a collaborative engineering system to include distributed analysis, integrated tools, and web-enabled graphics. Engineers on the IM&S team were tasked with applying IM&S capabilities to an orbital mechanics analysis for a lunar mission study. An interactive lunar globe was created to show 7 landing sites, contour lines depicting the energy required to reach a given site, and the optimal lunar orbit orientation to meet the mission constraints. Activation of the lunar globe rotation shows the change of the angle between the landing site latitude and the orbit plane. A heads-up-display was used to embed straightforward interface elements.

Life-Cycle Cost Analysis for Small Unmanned Aircraft Systems Deployed Aboard Coast Guard Cutters

DTIC Science & Technology

2013-12-09

safest way to survey the NBC disaster site. “Swarms could scan high-risk buildings and sites (think Fukushima ^Åèìáëáíáçå=oÉëÉ~êÅÜ=mêçÖê~ã= dê~Çì~íÉ...in 1997 with a degree in mechanical engineering. After graduation, he served onboard USCGC Thetis (WMEC-910) as the student engineer and damage...the surrounding area with his family. After graduation in December 2013, he will report to the In-Service Vessel Sustainment Project as assistant

Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering.

PubMed

Zhao, Wen; Li, Jiaojiao; Jin, Kaixiang; Liu, Wenlong; Qiu, Xuefeng; Li, Chenrui

2016-02-01

Electrospun PLGA-based scaffolds have been applied extensively in biomedical engineering, such as tissue engineering and drug delivery system. Due to lack of the recognition sites on cells, hydropholicity and single-function, the applications of PLGA fibrous scaffolds are limited. In order to tackle these issues, many works have been done to obtain functional PLGA-based scaffolds, including surface modifications, the fabrication of PLGA-based composite scaffolds and drug-loaded scaffolds. The functional PLGA-based scaffolds have significantly improved cell adhesion, attachment and proliferation. Moreover, the current study has summarized the applications of functional PLGA-based scaffolds in wound dressing, vascular and bone tissue engineering area as well as drug delivery system. Copyright © 2015 Elsevier B.V. All rights reserved.

The ATLAS Software Installation System v2: a highly available system to install and validate Grid and Cloud sites via Panda

NASA Astrophysics Data System (ADS)

De Salvo, A.; Kataoka, M.; Sanchez Pineda, A.; Smirnov, Y.

2015-12-01

The ATLAS Installation System v2 is the evolution of the original system, used since 2003. The original tool has been completely re-designed in terms of database backend and components, adding support for submission to multiple backends, including the original Workload Management Service (WMS) and the new PanDA modules. The database engine has been changed from plain MySQL to Galera/Percona and the table structure has been optimized to allow a full High-Availability (HA) solution over Wide Area Network. The servlets, running on each frontend, have been also decoupled from local settings, to allow an easy scalability of the system, including the possibility of an HA system with multiple sites. The clients can also be run in multiple copies and in different geographical locations, and take care of sending the installation and validation jobs to the target Grid or Cloud sites. Moreover, the Installation Database is used as source of parameters by the automatic agents running in CVMFS, in order to install the software and distribute it to the sites. The system is in production for ATLAS since 2013, having as main sites in HA the INFN Roma Tier 2 and the CERN Agile Infrastructure. The Light Job Submission Framework for Installation (LJSFi) v2 engine is directly interfacing with PanDA for the Job Management, the Atlas Grid Information System (AGIS) for the site parameter configurations, and CVMFS for both core components and the installation of the software itself. LJSFi2 is also able to use other plugins, and is essentially Virtual Organization (VO) agnostic, so can be directly used and extended to cope with the requirements of any Grid or Cloud enabled VO. In this work we will present the architecture, performance, status and possible evolutions to the system for the LHC Run2 and beyond.

47 CFR 27.1180 - The cost-sharing formula.

Code of Federal Regulations, 2013 CFR

2013-10-01

... § 27.1180 The cost-sharing formula. (a) An AWS licensee that relocates a BRS system with which it... forth in paragraph (b) of this section. (b) C is the actual cost of relocating the system, and includes... equipment; engineering costs (design/path survey); installation; systems testing; FCC filing costs; site...

Stellar Interferometer Technology Experiment (SITE)

NASA Technical Reports Server (NTRS)

Crawley, Edward F.; Miller, David; Laskin, Robert; Shao, Michael

1995-01-01

The MIT Space Engineering Research Center and the Jet Propulsion Laboratory stand ready to advance science sensor technology for discrete-aperture astronomical instruments such as space-based optical interferometers. The objective of the Stellar Interferometer Technology Experiment (SITE) is to demonstrate system-level functionality of a space-based stellar interferometer through the use of enabling and enhancing Controlled-Structures Technologies (CST). SITE mounts to the Mission Peculiar Experiment Support System inside the Shuttle payload bay. Starlight, entering through two apertures, is steered to a combining plate where it is interferred. Interference requires 27 nanometer pathlength (phasing) and 0.29 archsecond wavefront-tilt (pointing) control. The resulting 15 milli-archsecond angular resolution exceeds that of current earth-orbiting telescopes while maintaining low cost by exploiting active optics and structural control technologies. With these technologies, unforeseen and time-varying disturbances can be rejected while relaxing reliance on ground alignment and calibration. SITE will reduce the risk and cost of advanced optical space systems by validating critical technologies in their operational environment. Moreover, these technologies are directly applicable to commercially driven applications such as precision matching, optical scanning, and vibration and noise control systems for the aerospace, medical, and automotive sectors. The SITE team consists of experienced university, government, and industry researchers, scientists, and engineers with extensive expertise in optical interferometry, nano-precision opto-mechanical control and spaceflight experimentation. The experience exists and the technology is mature. SITE will validate these technologies on a functioning interferometer science sensor in order to confirm definitely their readiness to be baselined for future science missions.

Center for By-Products Utilization (CBU) | College of Engineering & Applied

Science.gov Websites

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Geohydrologic aspects for siting and design of low-level radioactive-waste disposal

USGS Publications Warehouse

Bedinger, M.S.

1989-01-01

The objective for siting and design of low-level radioactive-waste repository sites is to isolate the waste from the biosphere until the waste no longer poses an unacceptable hazard as a result of radioactive decay. Low-level radioactive waste commonly is isolated at shallow depths with various engineered features to stabilize the waste and to reduce its dissolution and transport by ground water. The unsaturated zone generally is preferred for isolating the waste. Low-level radioactive waste may need to be isolated for 300 to 500 years. Maintenance and monitoring of the repository site are required by Federal regulations for only the first 100 years. Therefore, geohydrology of the repository site needs to provide natural isolation of the waste for the hazardous period following maintenance of the site. Engineering design of the repository needs to be compatible with the natural geohydrologic conditions at the site. Studies at existing commercial and Federal waste-disposal sites provide information on the problems encountered and the basis for establishing siting guidelines for improved isolation of radioactive waste, engineering design of repository structures, and surveillance needs to assess the effectiveness of the repositories and to provide early warning of problems that may require remedial action.Climate directly affects the hydrology of a site and probably is the most important single factor that affects the suitability of a site for shallow-land burial of low-level radioactive waste. Humid and subhumid regions are not well suited for shallow isolation of low-level radioactive waste in the unsaturated zone; arid regions with zero to small infiltration from precipitation, great depths to the water table, and long flow paths to natural discharge areas are naturally well suited to isolation of the waste. The unsaturated zone is preferred for isolation of low-level radioactive waste. The guiding rationale is to minimize contact of water with the waste and to minimize transport of waste from the repository. The hydrology of a flow system containing a repository is greatly affected by the engineering of the repository site. Prediction of the performance of the repository is a complex problem, hampered by problems of characterizing the natural and manmade features of the flow system and by the limitations of models to predict flow and geochemical processes in the saturated and unsaturated zones. Disposal in low-permeability unfractured clays in the saturated zone may be feasible where the radionuclide transport is controlled by diffusion rather than advection.

Newly Engineered Magnetic Erythrocytes for Sustained and Targeted Delivery of Anti-Cancer Therapeutic Compounds

PubMed Central

Taranta, Monia; Naldi, Ilaria

2011-01-01

Cytotoxic chemotherapy of cancer is limited by serious, sometimes life-threatening, side effects that arise from toxicities to sensitive normal cells because the therapies are not selective for malignant cells. So how can they be selectively improved? Alternative pharmaceutical formulations of anti-cancer agents have been investigated in order to improve conventional chemotherapy treatment. These formulations are associated with problems like severe toxic side effects on healthy organs, drug resistance and limited access of the drug to the tumor sites suggested the need to focus on site-specific controlled drug delivery systems. In response to these concerns, we have developed a new drug delivery system based on magnetic erythrocytes engineered with a viral spike fusion protein. This new erythrocyte-based drug delivery system has the potential for magnetic-controlled site-specific localization and highly efficient fusion capability with the targeted cells. Here we show that the erythro-magneto-HA virosomes drug delivery system is able to attach and fuse with the target cells and to efficiently release therapeutic compounds inside the cells. The efficacy of the anti-cancer drug employed is increased and the dose required is 10 time less than that needed with conventional therapy. PMID:21373641

A 50 kilowatt distributed grid-connected photovoltaic generation system for the University of Wyoming

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chowdhury, B.H.; Muknahallipatna, S.; Cupal, J.J.

The University of Wyoming (UW) campus is serving as the site for a 50 kilowatt solar photovoltaic (PV) system. Three sub-systems were sited and built on the UW campus in 1996. The first sub-system, a 10 kW roof-integrated system of PV roof tiles is located on the roof of the Engineering building. The second sub-system--a 5 kW rack-mounted, ballasted PV system is on a walkway roof of the Engineering building. The third sub-system is a 35 kW shade structure system and located adjacent to the parking lot of the university`s football stadium. The three sub-systems differ in their design strategymore » since each is being used for research and education at the university. Each sub-system, being located at some distance away from one another, supplies a different part of the campus grid. Efforts continue at setting up a central monitoring system which will receive data remotely from all locations. A part of this monitoring system is complete. While the initial monitoring data shows satisfactory performance, a number of reliability problems with PV modules and inverters have delayed full functionality of the system.« less

47 CFR 24.243 - The cost-sharing formula.

Code of Federal Regulations, 2010 CFR

2010-10-01

...; monitoring or control equipment; engineering costs (design/path survey); installation; systems testing; FCC filing costs; site acquisition and civil works; zoning costs; training; disposal of old equipment; test...

Web survey data collection and retrieval to plan teleradiology implementation

NASA Astrophysics Data System (ADS)

Alaoui, Adil; Collmann, Jeff R.; Johnson, Jeffrey A.; Lindisch, David; Nguyen, Dan; Mun, Seong K.

2003-05-01

This case study details the experience of system engineers of the Imaging Science and Information Systems Center, Georgetown University Medical Center (ISIS) and radiologists from the department of Radiology in the implementation of a new Teleradiology system. The Teleradiology system enables radiologists to view medical images from remote sites under those circumstances where a resident radiologist needs assistance in evaluating the images after hours and during weekends; it also enables clinicians access to patients" medical images from different workstations within the hospital. The Implementation of the Teleradiology project was preceded by an evaluation phase to perform testing, gather users feedback using a web site and collect information that helped eliminate system bugs, complete recommendations regarding minimum hardware configuration and bandwidth and enhance system"s functions, this phase included a survey-based system assessment of computer configurations, Internet connections, problem identification, and recommendations for improvement, and a testing period with 2 radiologists and ISIS engineers; The second phase was designed to launch the system and make it available to all attending radiologists in the department. To accomplish the first phase of the project a web site was designed and ASP pages were created to enable users to securely logon and enter feedback and recommendations into an SQL database. This efficient, accurate data flow alleviated networking, software and hardware problems. Corrective recommendations were immediately forwarded to the software vendor. The vendor responded with software updates that better met the needs of the radiologists. The ISIS Center completed recommendations for minimum hardware and bandwidth requirements. This experience illustrates that the approach used in collecting the data and facilitating the teamwork between the system engineers and radiologists was instrumental in the project"s success. Major problems with the Teleradiology system were discovered and remedied early by linking the actual practice experience of the physicians to the system improvements.

Environmental sciences information storage and retrieval system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engstrom, D.E.; White, M.G.; Dunaway, P.B.

Reynolds Electrical and Engineering Co., Inc. (REECo), has since 1970 accumulated information relating to the AEC's Nevada Applied Ecology Group (NAEG) programs at the Nevada Test Site (NTS). These programs, involving extensive soil, vegetation, and small-animal studies, have generated informational data concerning the collecting, processing, analyzing, and shipping of sample materials to various program participants and contractors. Future plans include incorporation of Lawrence Livermore Laboratory's resuspension study data, REECo's on-site air data, and EPA's large-animal, off-site air, and off-site soil data. (auth)

Astronomy Village Reaches for New Heights

NASA Astrophysics Data System (ADS)

Croft, S. K.; Pompea, S. M.

2007-12-01

We are developing a set of complex, multimedia-based instructional modules emphasizing technical and scientific issues related to Giant Segmented Mirror Telescope project. The modules" pedagogy will be open-ended and problem-based to promote development of problem-solving skills. Problem- based-learning modules that emphasize work on open-ended complex real world problems are particularly valuable in illustrating and promoting a perspective on the process of science and engineering. Research in this area shows that these kinds of learning experiences are superior to more conventional student training in terms of gains in student learning. The format for the modules will be based on the award-winning multi-media educational Astronomy Village products that present students with a simulated environment: a mountaintop community surrounded by a cluster of telescopes, satellite receivers, and telecommunication towers. A number of "buildings" are found in the Village, such as a library, a laboratory, and an auditorium. Each building contains an array of information sources and computer simulations. Students navigate through their research with a mentor via imbedded video. The first module will be "Observatory Site Selection." Students will use astronomical data, basic weather information, and sky brightness data to select the best site for an observatory. Students will investigate the six GSMT sites considered by the professional site selection teams. Students will explore weather and basic site issues (e.g., roads and topography) using remote sensing images, computational fluid dynamics results, turbulence profiles, and scintillation of the different sites. Comparison of student problem solving with expert problem solving will also be done as part of the module. As part of a site selection team they will have to construct a case and present it on why they chose a particular site. The second module will address aspects of system engineering and optimization for a GSMT-like telescope. Basic system issues will be addressed and studied. These might include various controls issues and optimization issues such as mirror figure, mirror support stability, and wind loading trade-offs. Using system modeling and system optimization results from existing and early GSMT trade studies, we will create a simulation where students are part of an engineering design and optimization team. They will explore the cost/performance/schedule issues associate with the GSMT design.

Minority Universities Systems Engineering (MUSE) Program at the University of Texas at El Paso

NASA Technical Reports Server (NTRS)

Robbins, Mary Clare; Usevitch, Bryan; Starks, Scott A.

1997-01-01

In 1995, The University of Texas at El Paso (UTEP) responded to the suggestion of NASA Jet Propulsion Laboratory (NASA JPL) to form a consortium comprised of California State University at Los Angeles (CSULA), North Carolina Agricultural and Technical University (NCAT), and UTEP from which developed the Minority Universities Systems Engineering (MUSE) Program. The mission of this consortium is to develop a unique position for minority universities in providing the nation's future system architects and engineers as well as enhance JPL's system design capability. The goals of this collaboration include the development of a system engineering curriculum which includes hands-on project engineering and design experiences. UTEP is in a unique position to take full advantage of this program since UTEP has been named a Model Institution for Excellence (MIE) by the National Science Foundation. The purpose of MIE is to produce leaders in Science, Math, and Engineering. Furthermore, UTEP has also been selected as the site for two new centers including the Pan American Center for Earth and Environmental Sciences (PACES) directed by Dr. Scott Starks and the FAST Center for Structural Integrity of Aerospace Systems directed by Dr. Roberto Osegueda. The UTEP MUSE Program operates under the auspices of the PACES Center.

Engineering Molecular Immunity Against Plant Viruses.

PubMed

Zaidi, Syed Shan-E-Ali; Tashkandi, Manal; Mahfouz, Magdy M

2017-01-01

Genomic engineering has been used to precisely alter eukaryotic genomes at the single-base level for targeted gene editing, replacement, fusion, and mutagenesis, and plant viruses such as Tobacco rattle virus have been developed into efficient vectors for delivering genome-engineering reagents. In addition to altering the host genome, these methods can target pathogens to engineer molecular immunity. Indeed, recent studies have shown that clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) systems that target the genomes of DNA viruses can interfere with viral activity and limit viral symptoms in planta, demonstrating the utility of this system for engineering molecular immunity in plants. CRISPR/Cas9 can efficiently target single and multiple viral infections and confer plant immunity. Here, we discuss the use of site-specific nucleases to engineer molecular immunity against DNA and RNA viruses in plants. We also explore how to address the potential challenges encountered when producing plants with engineered resistance to single and mixed viral infections. © 2017 Elsevier Inc. All rights reserved.

A Global Survey and Interactive Map Suite of Deep Underground Facilities; Examples of Geotechnical and Engineering Capabilities, Achievements, Challenges: (Mines, Shafts, Tunnels, Boreholes, Sites and Underground Facilities for Nuclear Waste and Physics R&D)

NASA Astrophysics Data System (ADS)

Tynan, M. C.; Russell, G. P.; Perry, F.; Kelley, R.; Champenois, S. T.

2017-12-01

This global survey presents a synthesis of some notable geotechnical and engineering information reflected in four interactive layer maps for selected: 1) deep mines and shafts; 2) existing, considered or planned radioactive waste management deep underground studies, sites, or disposal facilities; 3) deep large diameter boreholes, and 4) physics underground laboratories and facilities from around the world. These data are intended to facilitate user access to basic information and references regarding deep underground "facilities", history, activities, and plans. In general, the interactive maps and database [http://gis.inl.gov/globalsites/] provide each facility's approximate site location, geology, and engineered features (e.g.: access, geometry, depth, diameter, year of operations, groundwater, lithology, host unit name and age, basin; operator, management organization, geographic data, nearby cultural features, other). Although the survey is not all encompassing, it is a comprehensive review of many of the significant existing and historical underground facilities discussed in the literature addressing radioactive waste management and deep mined geologic disposal safety systems. The global survey is intended to support and to inform: 1) interested parties and decision makers; 2) radioactive waste disposal and siting option evaluations, and 3) safety case development as a communication tool applicable to any mined geologic disposal facility as a demonstration of historical and current engineering and geotechnical capabilities available for use in deep underground facility siting, planning, construction, operations and monitoring.

Research on advanced transportation systems

NASA Astrophysics Data System (ADS)

Nagai, Hirokazu; Hashimoto, Ryouhei; Nosaka, Masataka; Koyari, Yukio; Yamada, Yoshio; Noda, Keiichirou; Shinohara, Suetsugu; Itou, Tetsuichi; Etou, Takao; Kaneko, Yutaka

1992-08-01

An overview of the researches on advanced space transportation systems is presented. Conceptual study is conducted on fly back boosters with expendable upper stage rocket systems assuming a launch capacity of 30 tons and returning to the launch site by the boosters, and prospect of their feasibility is obtained. Reviews are conducted on subjects as follows: (1) trial production of 10 tons sub scale engines for the purpose of acquiring hardware data and picking up technical problems for full scale 100 tons thrust engines using hydrocarbon fuels; (2) development techniques for advanced liquid propulsion systems from the aspects of development schedule, cost; (3) review of conventional technologies, and common use of component; (4) oxidant switching propulsion systems focusing on feasibility of Liquefied Air Cycle Engine (LACE) and Compressed Air Cycle Engine (CACE); (5) present status of slosh hydrogen manufacturing, storage, and handling; (6) construction of small high speed dynamometer for promoting research on mini pump development; (7) hybrid solid boosters under research all over the world as low-cost and clean propulsion systems; and (8) high performance solid propellant for upper stage and lower stage propulsion systems.

Advanced Engineering Environment FY09/10 pilot project.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamph, Jane Ann; Kiba, Grant W.; Pomplun, Alan R.

2010-06-01

The Advanced Engineering Environment (AEE) project identifies emerging engineering environment tools and assesses their value to Sandia National Laboratories and our partners in the Nuclear Security Enterprise (NSE) by testing them in our design environment. This project accomplished several pilot activities, including: the preliminary definition of an engineering bill of materials (BOM) based product structure in the Windchill PDMLink 9.0 application; an evaluation of Mentor Graphics Data Management System (DMS) application for electrical computer-aided design (ECAD) library administration; and implementation and documentation of a Windchill 9.1 application upgrade. The project also supported the migration of legacy data from existing corporatemore » product lifecycle management systems into new classified and unclassified Windchill PDMLink 9.0 systems. The project included two infrastructure modernization efforts: the replacement of two aging AEE development servers for reliable platforms for ongoing AEE project work; and the replacement of four critical application and license servers that support design and engineering work at the Sandia National Laboratories/California site.« less

Variability of patient spine education by Internet search engine.

PubMed

Ghobrial, George M; Mehdi, Angud; Maltenfort, Mitchell; Sharan, Ashwini D; Harrop, James S

2014-03-01

Patients are increasingly reliant upon the Internet as a primary source of medical information. The educational experience varies by search engine, search term, and changes daily. There are no tools for critical evaluation of spinal surgery websites. To highlight the variability between common search engines for the same search terms. To detect bias, by prevalence of specific kinds of websites for certain spinal disorders. Demonstrate a simple scoring system of spinal disorder website for patient use, to maximize the quality of information exposed to the patient. Ten common search terms were used to query three of the most common search engines. The top fifty results of each query were tabulated. A negative binomial regression was performed to highlight the variation across each search engine. Google was more likely than Bing and Yahoo search engines to return hospital ads (P=0.002) and more likely to return scholarly sites of peer-reviewed lite (P=0.003). Educational web sites, surgical group sites, and online web communities had a significantly higher likelihood of returning on any search, regardless of search engine, or search string (P=0.007). Likewise, professional websites, including hospital run, industry sponsored, legal, and peer-reviewed web pages were less likely to be found on a search overall, regardless of engine and search string (P=0.078). The Internet is a rapidly growing body of medical information which can serve as a useful tool for patient education. High quality information is readily available, provided that the patient uses a consistent, focused metric for evaluating online spine surgery information, as there is a clear variability in the way search engines present information to the patient. Published by Elsevier B.V.

Perchlorate Removal, Destruction, and Field Monitoring Demonstration

DTIC Science & Technology

2006-10-02

ion exchange unit. A pulsation dampener minimized pressure and flow fluctuations in the ion exchange system and a flow totalizer monitored total...instrumentation and controls, piping , electrical services, site work, service facilities, engineering, construction expenses, and other indirect costs were... Piping 113,750 157,500 Electrical services 48,750 67,500 Site work 65,000 90,000

27. AERIAL VIEW OF ARVFS FIELD TEST SITE AS IT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. AERIAL VIEW OF ARVFS FIELD TEST SITE AS IT LOOKED IN 1983. OBLIQUE VIEW FACING EAST. BUNKER IS IN FOREGROUND, PROTECTIVE SHED FOR WFRP AT TOP OF IMAGE. INEL PHOTO NUMBER 83-574-12-1, TAKEN IN 1983. PHOTOGRAPHER: ROMERO. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

The Effectiveness of Web Search Engines to Index New Sites from Different Countries

ERIC Educational Resources Information Center

Pirkola, Ari

2009-01-01

Introduction: Investigates how effectively Web search engines index new sites from different countries. The primary interest is whether new sites are indexed equally or whether search engines are biased towards certain countries. If major search engines show biased coverage it can be considered a significant economic and political problem because…

75 FR 28296 - Clark Engineering Co., Inc., Including On-Site Leased Workers From Kelly Services and Qualified...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,773] Clark Engineering Co... of Clark Engineering Co., Inc., including on-site leased workers of Kelly Services, Owosso, Michigan... from Qualified Staffing were employed on-site at the Owosso, Michigan location of Clark Engineering Co...

75 FR 55613 - General Motors Corporation, Renaissance Center, Including On-Site Leased Workers From Accretive...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

...., Acro Service Corporation, Aerotek, Inc., Ajilon Consulting, Altair Engineering, Inc., Aquent LLC, Global Technology Associates, Ltd, JDM Systems Consultants, Inc., Kelly Service, Inc., Populus Group... Technology Associates, Ltd., JDM Systems Consultants, Inc., Kelly Service, Inc., Populus Group, TEKsystems...

76 FR 13664 - Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... International, Manpower, Acro Service Corp., Adecco, Inc., Aerotek, Inc., CDI Corporation, Emergent Systems Corp... Manpower, Van Buren Township, Michigan. The workers are engaged in the manufacturing of automotive systems. The Visteon Headquarter sites provide support services including research, engineering, manufacturing...

49 CFR 229.211 - Processing of petitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Docket Management System and posted on its Web site at http://www.regulations.gov. (3) In the event FRA..., FRA will consider proper documentation of competent engineering analysis, or practical demonstrations...

49 CFR 229.211 - Processing of petitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Docket Management System and posted on its Web site at http://www.regulations.gov. (3) In the event FRA..., FRA will consider proper documentation of competent engineering analysis, or practical demonstrations...

Launch Vehicle Control Center Architectures

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Epps, Amy; Woodruff, Van; Vachon, Michael Jacob; Monreal, Julio; Williams, Randall; McLaughlin, Tom

2014-01-01

This analysis is a survey of control center architectures of the NASA Space Launch System (SLS), United Launch Alliance (ULA) Atlas V and Delta IV, and the European Space Agency (ESA) Ariane 5. Each of these control center architectures have similarities in basic structure, and differences in functional distribution of responsibilities for the phases of operations: (a) Launch vehicles in the international community vary greatly in configuration and process; (b) Each launch site has a unique processing flow based on the specific configurations; (c) Launch and flight operations are managed through a set of control centers associated with each launch site, however the flight operations may be a different control center than the launch center; and (d) The engineering support centers are primarily located at the design center with a small engineering support team at the launch site.

Construction site Voice Operated Information System (VOIS) test

NASA Astrophysics Data System (ADS)

Lawrence, Debbie J.; Hettchen, William

1991-01-01

The Voice Activated Information System (VAIS), developed by USACERL, allows inspectors to verbally log on-site inspection reports on a hand held tape recorder. The tape is later processed by the VAIS, which enters the information into the system's database and produces a written report. The Voice Operated Information System (VOIS), developed by USACERL and Automated Sciences Group, through a ESACERL cooperative research and development agreement (CRDA), is an improved voice recognition system based on the concepts and function of the VAIS. To determine the applicability of the VOIS to Corps of Engineers construction projects, Technology Transfer Test Bad (T3B) funds were provided to the Corps of Engineers National Security Agency (NSA) Area Office (Fort Meade) to procure and implement the VOIS, and to train personnel in its use. This report summarizes the NSA application of the VOIS to quality assurance inspection of radio frequency shielding and to progress payment logs, and concludes that the VOIS is an easily implemented system that can offer improvements when applied to repetitive inspection procedures. Use of VOIS can save time during inspection, improve documentation storage, and provide flexible retrieval of stored information.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deline, Chris; Dann, Geoff

Recent increases in photovoltaic (PV) systems on Department of the Navy (DON) land and potential siting near airfields prompted Commander, Naval Installations Command to fund the Naval Facilities Engineering Command to evaluate the impact of electromagnetic interference (EMI) from PV systems on airfield electronic equipment. Naval Facilities Engineering and Expeditionary Warfare Center tasked Department of Energy National Renewable Energy laboratory (NREL) to conduct the assessment. PV systems often include high-speed switching semiconductor circuits to convert the voltage produced by the PV arrays to the voltage needed by the end user. Switching circuits inherently produce electromagnetic radiation at harmonics of themore » switching frequency. In this report, existing literature is summarized and tests to measure emissions and mitigation methods are discussed. The literature shows that the emissions from typical PV systems are low strength and unlikely to cause interference to most airfield electronic systems. With diligent procurement and siting of PV systems, including specifications for FCC Part 15 Class A compliant equipment and a 250-foot setback from communication equipment, NREL anticipates little to no EMI impact on nearby communications or telemetry equipment.« less

Teen smoking cessation help via the Internet: a survey of search engines.

PubMed

Edwards, Christine C; Elliott, Sean P; Conway, Terry L; Woodruff, Susan I

2003-07-01

The objective of this study was to assess Web sites related to teen smoking cessation on the Internet. Seven Internet search engines were searched using the keywords teen quit smoking. The top 20 hits from each search engine were reviewed and categorized. The keywords teen quit smoking produced between 35 and 400,000 hits depending on the search engine. Of 140 potential hits, 62% were active, unique sites; 85% were listed by only one search engine; and 40% focused on cessation. Findings suggest that legitimate on-line smoking cessation help for teens is constrained by search engine choice and the amount of time teens spend looking through potential sites. Resource listings should be updated regularly. Smoking cessation Web sites need to be picked up on multiple search engine searches. Further evaluation of smoking cessation Web sites need to be conducted to identify the most effective help for teens.

Genome editing: the road of CRISPR/Cas9 from bench to clinic

PubMed Central

Eid, Ayman; Mahfouz, Magdy M

2016-01-01

Molecular scissors engineered for site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes and could improve our understanding of the molecular underpinnings of disease states and facilitate novel therapeutic applications. Several platforms for molecular scissors that enable targeted genome engineering have been developed, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and, most recently, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated-9 (Cas9). The CRISPR/Cas9 system's simplicity, facile engineering and amenability to multiplexing make it the system of choice for many applications. CRISPR/Cas9 has been used to generate disease models to study genetic diseases. Improvements are urgently needed for various aspects of the CRISPR/Cas9 system, including the system's precision, delivery and control over the outcome of the repair process. Here, we discuss the current status of genome engineering and its implications for the future of biological research and gene therapy. PMID:27741224

Genome editing: the road of CRISPR/Cas9 from bench to clinic.

PubMed

Eid, Ayman; Mahfouz, Magdy M

2016-10-14

Molecular scissors engineered for site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes and could improve our understanding of the molecular underpinnings of disease states and facilitate novel therapeutic applications. Several platforms for molecular scissors that enable targeted genome engineering have been developed, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and, most recently, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated-9 (Cas9). The CRISPR/Cas9 system's simplicity, facile engineering and amenability to multiplexing make it the system of choice for many applications. CRISPR/Cas9 has been used to generate disease models to study genetic diseases. Improvements are urgently needed for various aspects of the CRISPR/Cas9 system, including the system's precision, delivery and control over the outcome of the repair process. Here, we discuss the current status of genome engineering and its implications for the future of biological research and gene therapy.

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering.

PubMed

Kondiah, Pariksha J; Choonara, Yahya E; Kondiah, Pierre P D; Marimuthu, Thashree; Kumar, Pradeep; du Toit, Lisa C; Pillay, Viness

2016-11-21

Biodegradable, stimuli-responsive polymers are essential platforms in the field of drug delivery and injectable biomaterials for application of bone tissue engineering. Various thermo-responsive hydrogels display water-based homogenous properties to encapsulate, manipulate and transfer its contents to the surrounding tissue, in the least invasive manner. The success of bioengineered injectable tissue modified delivery systems depends significantly on their chemical, physical and biological properties. Irrespective of shape and defect geometry, injectable therapy has an unparalleled advantage in which intricate therapy sites can be effortlessly targeted with minimally invasive procedures. Using material testing, it was found that properties of stimuli-responsive hydrogel systems enhance cellular responses and cell distribution at any site prior to the transitional phase leading to gelation. The substantially hydrated nature allows significant simulation of the extracellular matrix (ECM), due to its similar structural properties. Significant current research strategies have been identified and reported to date by various institutions, with particular attention to thermo-responsive hydrogel delivery systems, and their pertinent focus for bone tissue engineering. Research on future perspective studies which have been proposed for evaluation, have also been reported in this review, directing considerable attention to the modification of delivering natural and synthetic polymers, to improve their biocompatibility and mechanical properties.

75 FR 52982 - Chrysler Group LLC, Formally Known as Chrysler LLC, Kenosha Engine Plant, Including On-Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... automobile engines. The company reports that workers leased from Syncreon were employed on-site at the..., Formally Known as Chrysler LLC, Kenosha Engine Plant, Including On-Site Leased Workers From Caravan Knight... Chrysler, LLC, Kenosha Engine Plant, Kenosha, Wisconsin. The notice was published in the Federal Register...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shafer, A.L.; Purdy, S.; Tempelis, D.

The La Paz County Regional Landfill is a 65 hectare (160 acre) municipal waste site located near the western border of Arizona between the cities of Parker and Quartzsite. The site is operated under a public/private partnership between the County of La Paz and Browning-Ferris Industries, Inc. (BFI). The County owns the landfill and infrastructure and BFI is responsible for facility improvements, environmental compliance, and daily operations. Following the initial permitting and construction of the first landfill cell, a value engineering review was conducted on the site design and permit requirements. Based on this review, substantial cost saving opportunities weremore » identified. In order to implement the value engineering ideas, the site permit was modified and a new Solid Waste Facilities Plan was Submitted to the Arizona Department of Environmental Quality. This paper discusses the value engineering modifications that were conducted, the revisions to the permits, and the relative cost savings that were realized. The areas addressed include the liner system design, closure design, disposal capacity, and operations plan. Through the use of alternative liners a cost savings of well over 50 percent (as compared to the original permit) will be realized over the life of the landfill.« less

Munitions Test Area and Incendiary Drop Site, Site 36-2, Data Addendum, Phase 2.

DTIC Science & Technology

1988-09-01

MUNITIONS TEST AREA AND INCENDIARY DROP SITE (NI September 1988 Contract Number DAAK11-84-D-0016 | • (Version 3.1) Environmental Science And Engineering, Inc...SITE, September 1988 Contract Number DAAK11-84-D-0016 (Version 3.1)I PREPARED BY ENVIRONMENTAL SCIENCE AND ENGINEERING, INC. Harding Lawson Associates I...the Program Managers Office (PMO). Environmental Science and Engineering (ESE), Morrison-Knudsen Engineers (MKE), and Harding Lawson Associates (HLA

The spread of European models of engineering education: the challenges faced in emerging countries

NASA Astrophysics Data System (ADS)

Gardelle, Linda; Cardona Gil, Emmanuel; Benguerna, Mohamed; Bolat, Altangul; Naran, Boldmaa

2017-03-01

The major European models of engineering training (the German, the British and the French model) spread throughout the world during the twentieth century. Historical heritage, cultural proximity and languages explain the open expression of faithfulness to one system in some countries. In these countries, the national standards inherited are now completed by international standards or are in direct competition with new influences. This article will attempt, through the existing literature, interviews and on-site investigations, to analyse current engineering training in some emerging countries and its relations with European models, the objective being to analyse the evolution of local systems and so the challenges and issues raised by the dissemination of European models.

Infiltration performance of engineered surfaces commonly used for distributed stormwater management

NASA Astrophysics Data System (ADS)

Valinski, Nicholas A.

Engineered porous media are commonly used in low impact development (LID) structures to mitigate excess stormwater in urban environments. Differences in infiltrability of these LID systems arise from the wide variety of materials used to create porous surfaces and subsequent maintenance, debris loading, and physical damage. In this study, infiltration capacity of six common materials was tested by multiple replicate experiments with automated mini-disk infiltrometers. The tested materials included porous asphalt, porous concrete, porous brick pavers, flexible porous pavement, engineered soils, and native soils. Porous asphalt, large porous brick pavers, and curb cutout rain gardens showed the greatest infiltration rates. Most engineered porous pavements and soils performed better than the native silt loam soils. Infiltration performance was found to be related more to site design and environmental factors than material choice. Sediment trap zones in both pavements and engineered soil rain gardens were found to be beneficial to the whole site performance. Winter chloride application had a large negative impact on poured in place concrete, making it a poor choice for heavily salted areas.

Infiltration performance of engineered surfaces commonly used for distributed stormwater management.

PubMed

Valinski, N A; Chandler, D G

2015-09-01

Engineered porous media are commonly used in low impact development (LID) structures to mitigate excess stormwater in urban environments. Differences in infiltrability of these LID systems arise from the wide variety of materials used to create porous surfaces and subsequent maintenance, debris loading, and physical damage. In this study, the infiltration capacity of six common materials was tested by multiple replicate experiments with automated mini-disk infiltrometers. The tested materials included porous asphalt, porous concrete, porous brick pavers, flexible porous pavement, engineered soils, and native soils. Porous asphalt, large porous brick pavers, and curb cutout rain gardens showed the greatest infiltration rates. Most engineered porous pavements and soils performed better than the native silt loam soils. Infiltration performance was found to be related more to site design and environmental factors than material choice. Sediment trap zones in both pavements and engineered soil rain gardens were found to be beneficial to the whole site performance. Winter chloride application had a large negative impact on poured in place concrete, making it a poor choice for heavily salted areas. Copyright © 2015 Elsevier Ltd. All rights reserved.

Parabolic dish systems at work - Applying the concepts

NASA Technical Reports Server (NTRS)

Marriott, A. T.

1981-01-01

An overview is given of parabolic dish solar concentrator application experiments being conducted by the U.S. Department of Energy. The 'engineering experiments' comprise the testing of (1) a small-community powerplant system, in conjunction with a grid-connected utility; (2) stand-alone applications at remote sites such as military installations, radar stations and villages; and (3) dish modules that can deliver heat for direct use in industrial processes. Applicability projections are based on a dish and receiver that use a Brayton engine with an engine/generator efficiency of 25% and a production level of up to 25,000 units per year. Analyses indicate that parabolic-dish power systems can potentially replace small, oil-fired power plants in all regions of the U.S. between 1985 and 1991.

Generation of a Knockout Mouse Embryonic Stem Cell Line Using a Paired CRISPR/Cas9 Genome Engineering Tool.

PubMed

Wettstein, Rahel; Bodak, Maxime; Ciaudo, Constance

2016-01-01

CRISPR/Cas9, originally discovered as a bacterial immune system, has recently been engineered into the latest tool to successfully introduce site-specific mutations in a variety of different organisms. Composed only of the Cas9 protein as well as one engineered guide RNA for its functionality, this system is much less complex in its setup and easier to handle than other guided nucleases such as Zinc-finger nucleases or TALENs.Here, we describe the simultaneous transfection of two paired CRISPR sgRNAs-Cas9 plasmids, in mouse embryonic stem cells (mESCs), resulting in the knockout of the selected target gene. Together with a four primer-evaluation system, it poses an efficient way to generate new independent knockout mouse embryonic stem cell lines.

23 CFR 940.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of Transportation (DOT) and is available on the DOT web site at http://www.its.dot.gov. Project level... projects or groups of projects. Systems engineering is a structured process for arriving at a final design...

23 CFR 940.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... of Transportation (DOT) and is available on the DOT web site at http://www.its.dot.gov. Project level... projects or groups of projects. Systems engineering is a structured process for arriving at a final design...

48 CFR 301.607-71 - FAC-P/PM levels and requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... (2) The FAI describes the following three sets of general core competencies on its Web site: (3..., systems engineering, test and evaluation, contracting, and business. (6) Specific core competencies also...

A cognitive evaluation of four online search engines for answering definitional questions posed by physicians.

PubMed

Yu, Hong; Kaufman, David

2007-01-01

The Internet is having a profound impact on physicians' medical decision making. One recent survey of 277 physicians showed that 72% of physicians regularly used the Internet to research medical information and 51% admitted that information from web sites influenced their clinical decisions. This paper describes the first cognitive evaluation of four state-of-the-art Internet search engines: Google (i.e., Google and Scholar.Google), MedQA, Onelook, and PubMed for answering definitional questions (i.e., questions with the format of "What is X?") posed by physicians. Onelook is a portal for online definitions, and MedQA is a question answering system that automatically generates short texts to answer specific biomedical questions. Our evaluation criteria include quality of answer, ease of use, time spent, and number of actions taken. Our results show that MedQA outperforms Onelook and PubMed in most of the criteria, and that MedQA surpasses Google in time spent and number of actions, two important efficiency criteria. Our results show that Google is the best system for quality of answer and ease of use. We conclude that Google is an effective search engine for medical definitions, and that MedQA exceeds the other search engines in that it provides users direct answers to their questions; while the users of the other search engines have to visit several sites before finding all of the pertinent information.

10th Annual Systems Engineering Conference - Focusing on Improving Performance of Defense Systems Programs. Volume 1. Tuesday Presentations

DTIC Science & Technology

2007-10-25

Exchange Platforms Publishers Resellers iTunes Non-Profit/ Government/ Self- Managed Library of Congress Library Consortia Fed. Tech Transfer Sites Univ...Thompson Dialog – Thomson MicroPatent – Thomson Pharma – WIPO Digital Patent Library* (*nonprofit organization) • iTunes • IP Exchange Platforms...Elsevier SciDirect – Nat’l Acad. Press – Lexis, Westlaw – Newspaper web sites • iTunes • Resellers of Copyrighted Material – JSTOR – EBSCOHost

Solar Eclipse (1979) Part I. Atmospheric Sciences Laboratory Field Program Summary

DTIC Science & Technology

1980-05-01

from a location approximately 30 km southeast of the small rocket sites. The large rocket launch site was separated from the instrumentation site by...Ord, CA 93941 San Diego, CA 92152 SRI International Commander 4 ATTN: K2060/Dr. Edward E. Uthe Naval Ocean Systems Center 333 Ravenswood Avenue ATTN...Engineering Experiment Station ATTN: Code 4473 (Tech Library) ATTN: Dr. James C. Wiltse San Diego, CA 92152 Atlanta, GA 30332 The RANJD Corporation

The SKI repository performance assessment project Site-94

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andersson, J.; Dverstorp, B.; Sjoeblom, R.

1995-12-01

SITE-94 is a research project conducted as a performance assessment of a hypothetical repository for spent nuclear fuel, but with real pre-excavation data from a real site. The geosphere, the engineered barriers and the processes for radionuclide release and transport comprise an integrated interdependent system, which is described by an influence diagram (PID) that reflects how different Features, Events or Processes (FEPs) inside the system interact. Site evaluation is used to determine information of transport paths in the geosphere and to deliver information on geosphere interaction with the engineered barriers. A three-dimensional geological structure model of the site as wellmore » as alternative conceptual models consistent with the existing hydrological field data, have been analyzed. Groundwater chemistry is evaluated and a model, fairly consistent with the flow model, for the origin of the different waters has been developed. The geological structure model is also used for analyzing the mechanical stability of the site. Several phenomena of relevance for copper corrosion in a repository environment have been investigated. For Reference Case conditions and regardless of flow variability, output is dominated by I-129, which, for a single canister, may give rise to drinking water well doses in the order of 10{sup -6}Sv/yr. Finally, it appears that the procedures involved in the development of influence diagrams may be a promising tool for quality assurance of performance assessments.« less

Dynamics of a macroscopic model characterizing mutualism of search engines and web sites

NASA Astrophysics Data System (ADS)

Wang, Yuanshi; Wu, Hong

2006-05-01

We present a model to describe the mutualism relationship between search engines and web sites. In the model, search engines and web sites benefit from each other while the search engines are derived products of the web sites and cannot survive independently. Our goal is to show strategies for the search engines to survive in the internet market. From mathematical analysis of the model, we show that mutualism does not always result in survival. We show various conditions under which the search engines would tend to extinction, persist or grow explosively. Then by the conditions, we deduce a series of strategies for the search engines to survive in the internet market. We present conditions under which the initial number of consumers of the search engines has little contribution to their persistence, which is in agreement with the results in previous works. Furthermore, we show novel conditions under which the initial value plays an important role in the persistence of the search engines and deduce new strategies. We also give suggestions for the web sites to cooperate with the search engines in order to form a win-win situation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Link, P.K.

A total of 48 papers were presented at the Engineering Geology and Geotechnical Engineering 30th Symposium. These papers are presented in this proceedings under the following headings: site characterization--Pocatello area; site characterization--Boise Area; site assessment; Idaho National Engineering Laboratory; geophysical methods; remediation; geotechnical engineering; and hydrogeology, northern and western Idaho. Individual papers have been processed separately for inclusion in the Energy Science and Technology Database.

75 FR 453 - FLSMidth, Inc., Cement Division, Product Engineering, Including On-Site Leased Workers of Aerotek...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... Division, Product Engineering, Including On-Site Leased Workers of Aerotek Contract Engineering, Allied Personnel Services, Eastern Engineering, Hobbie Professional Services, Mccallion Staffing Specialists, Peak Technical Services, Inc., Yoh Engineering, and Clarke Consulting, Inc., Bethlehem, PA; Amended Certification...

Use of geographic information systems for applications on gas pipeline rights-of-way. Final report, December 1989--December 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, P.J.

1991-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way for this project (ROWs) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1)more » determination of environmentally sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWs; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, P.J.

1991-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way for this project (ROWs) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1)more » determination of environmentally sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWs; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

76 FR 24957 - Nineteenth Meeting: RTCA Special Committee 203: Unmanned Aircraft Systems

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

..., Washington, DC, 20036, telephone (202) 833-9339, fax (202) 833-9434, Web site http://www.rtca.org... Session Closing Plenary Session Plenary Adjourns RTCA Workspace Web Tool Mid-Morning/Afternoon--Workgroup Breakout Sessions Systems Engineering Workgroup Requirements Status and Overview AV2 Overview Control and...

Tierra Concrete Homes Honored with Energy Star Award

Science.gov Websites

building. NREL's research on low energy residences is sponsored by DOE's Building America Program. Building America conducts systems engineering research and system cost/performance tradeoffs to increase energy performance with minimal increases in housing cost. See the Building America Web site. Tierra Concrete Homes

47 CFR 101.75 - Involuntary relocation procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... engineering, equipment, site and FCC fees, as well as any legitimate and prudent transaction expenses incurred... reliability of their system. For digital data systems, reliability is measured by the percent of time the bit error rate (BER) exceeds a desired value, and for analog or digital voice transmissions, it is measured...

Fire Effects Information System: New engine, remodeled interior, added options

Treesearch

Jane Kapler Smith

2010-01-01

Some of today's firefighters weren't even born when the Fire Effects Information System (FEIS) (Web site ) "hit the streets" in 1986. Managers might remember using a dial-up connection in the early 1990s to access information on biology, ecology, and fire offered by FEIS.

Influences of specific ions in groundwater on concrete degradation in subsurface engineered barrier system.

PubMed

Lin, Wen-Sheng; Liu, Chen-Wuing; Li, Ming-Hsu

2016-01-01

Many disposal concepts currently show that concrete is an effective confinement material used in engineered barrier systems (EBS) at a number of low-level radioactive waste (LLW) disposal sites. Cement-based materials have properties for the encapsulation, isolation, or retardation of a variety of hazardous contaminants. The reactive chemical transport model of HYDROGEOCHEM 5.0 was applied to simulate the effect of hydrogeochemical processes on concrete barrier degradation in an EBS which has been proposed to use in the LLW disposal site in Taiwan. The simulated results indicated that the main processes that are responsible for concrete degradation are the species induced from hydrogen ion, sulfate, and chloride. The EBS with the side ditch drainage system effectively discharges the infiltrated water and lowers the solute concentrations that may induce concrete degradation. The redox processes markedly influence the formations of the degradation materials. The reductive environment in the EBS reduces the formation of ettringite in concrete degradation processes. Moreover, the chemical conditions in the concrete barriers maintain an alkaline condition after 300 years in the proposed LLW repository. This study provides a detailed picture of the long-term evolution of the hydrogeochemical environment in the proposed LLW disposal site in Taiwan.

Mars Exploration Rovers Launch Performance and TCM-1 Maneuver Design

NASA Technical Reports Server (NTRS)

Kangas, Julie A.; Potts, Christopher L.; Raofi, Behzad

2004-01-01

The Mars Exploration Rover (MER) project successfully landed two identical rovers on Mars in order to remotely conduct geologic investigations, including characterization of rocks and soils that may hold clues to past water activity. Two landing sites, Gusev crater and Meridiani Planum, were selected out of nearly 200 candidate sites after balancing science returns and flight system engineering and safety. Precise trajectory targeting and control was necessary to achieve the atmospheric entry requirements for the selected landing sites within the flight system constraints. This paper discusses the expected and achieved launch vehicle performance and the impacts of that performance on the first Trajectory Correction Maneuver (TCM-1) while maintaining targeting flexibility in accommodating additional project concerns about landing site safety and possible in-flight retargeting to alternate landing sites.

Reconfiguring practice: the interdependence of experimental procedure and computing infrastructure in distributed earthquake engineering.

PubMed

De La Flor, Grace; Ojaghi, Mobin; Martínez, Ignacio Lamata; Jirotka, Marina; Williams, Martin S; Blakeborough, Anthony

2010-09-13

When transitioning local laboratory practices into distributed environments, the interdependent relationship between experimental procedure and the technologies used to execute experiments becomes highly visible and a focal point for system requirements. We present an analysis of ways in which this reciprocal relationship is reconfiguring laboratory practices in earthquake engineering as a new computing infrastructure is embedded within three laboratories in order to facilitate the execution of shared experiments across geographically distributed sites. The system has been developed as part of the UK Network for Earthquake Engineering Simulation e-Research project, which links together three earthquake engineering laboratories at the universities of Bristol, Cambridge and Oxford. We consider the ways in which researchers have successfully adapted their local laboratory practices through the modification of experimental procedure so that they may meet the challenges of coordinating distributed earthquake experiments.

Efficient Genome Editing in Induced Pluripotent Stem Cells with Engineered Nucleases In Vitro.

PubMed

Termglinchan, Vittavat; Seeger, Timon; Chen, Caressa; Wu, Joseph C; Karakikes, Ioannis

2017-01-01

Precision genome engineering is rapidly advancing the application of the induced pluripotent stem cells (iPSCs) technology for in vitro disease modeling of cardiovascular diseases. Targeted genome editing using engineered nucleases is a powerful tool that allows for reverse genetics, genome engineering, and targeted transgene integration experiments to be performed in a precise and predictable manner. However, nuclease-mediated homologous recombination is an inefficient process. Herein, we describe the development of an optimized method combining site-specific nucleases and the piggyBac transposon system for "seamless" genome editing in pluripotent stem cells with high efficiency and fidelity in vitro.

Airborne remote sensors applied to engineering geology and civil works design investigations

NASA Technical Reports Server (NTRS)

Gelnett, R. H.

1975-01-01

The usefulness of various airborne remote sensing systems in the detection and identification of regional and specific geologic structural features that may affect the design and location of engineering structures on major civil works projects is evaluated. The Butler Valley Dam and Blue Lake Project in northern California was selected as a demonstration site. Findings derived from the interpretation of various kinds of imagery used are given.

Integrative systems and synthetic biology of cell-matrix adhesion sites.

PubMed

Zamir, Eli

2016-09-02

The complexity of cell-matrix adhesion convolves its roles in the development and functioning of multicellular organisms and their evolutionary tinkering. Cell-matrix adhesion is mediated by sites along the plasma membrane that anchor the actin cytoskeleton to the matrix via a large number of proteins, collectively called the integrin adhesome. Fundamental challenges for understanding how cell-matrix adhesion sites assemble and function arise from their multi-functionality, rapid dynamics, large number of components and molecular diversity. Systems biology faces these challenges in its strive to understand how the integrin adhesome gives rise to functional adhesion sites. Synthetic biology enables engineering intracellular modules and circuits with properties of interest. In this review I discuss some of the fundamental questions in systems biology of cell-matrix adhesion and how synthetic biology can help addressing them.

From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.

PubMed

MacEwan, Sarah R; Chilkoti, Ashutosh

2017-06-06

The molecular complexity and heterogeneity of cancer has led to a persistent, and as yet unsolved, challenge to develop cures for this disease. The pharmaceutical industry focuses the bulk of its efforts on the development of new drugs, but an alternative approach is to improve the delivery of existing drugs with drug carriers that can manipulate when, where, and how a drug exerts its therapeutic effect. For the treatment of solid tumors, systemically delivered drug carriers face significant challenges that are imposed by the pathophysiological barriers that lie between their site of administration and their site of therapeutic action in the tumor. Furthermore, drug carriers face additional challenges in their translation from preclinical validation to clinical approval and adoption. Addressing this diverse network of challenges requires a systems engineering approach for the rational design of optimized carriers that have a realistic prospect for translation from the laboratory to the patient. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

AFRL Solid Propellant Laboratory Explosive Siting and Renovation Lessons Learned

DTIC Science & Technology

2010-07-01

Area 1-30A explosive facility and provide consultation/support during the review process for each of the site plans. • Applied Engineering Services...provided consultation/support during the siting review process. • Applied Engineering Services (AES) Inc. performed a detailed structural, blast, thermal... Applied Engineering Services (AES) Inc. structural, blast, thermal and fragment hazard analysis to determine the appropriate siting values based on

Assessment of leachates from uncontrolled landfill: Tangier case study

NASA Astrophysics Data System (ADS)

Elmaghnougi, I.; Afilal Tribak, A.; Maatouk, M.

2018-05-01

Landfill site of Tangier City is non-engineered low lying open dump. It has neither bottom liner nor leachate collection and treatment system. Therefore, all the leachate generated finds its paths into the surrounding environment Leachate samples of landfill site were collected and analyzed to estimate its pollution potential. The analyzed samples contained a high concentration of organic and inorganic compounds, beyond the permissible limits.

Medical Surveillance Monthly Report (MSMR). Volume 19, Number 12, December 2012

DTIC Science & Technology

2012-12-01

Less com- monly, infection with Coccidioides can dis- seminate outside of the pulmonary system.6 Th e most common sites of extrapulmonary dissemination...soil, and it is impracticable to move all military bases and training sites outside of the endemic region. Available engineering controls to...appendectomy-related Current Procedural Terminology (CPT) codes (outpatient) 44950, 44955, 44960 Open appendectomy 44970, 44979 Laparoscopic appendectomy

Quantifying Genome Editing Outcomes at Endogenous Loci using SMRT Sequencing

PubMed Central

Clark, Joseph; Punjya, Niraj; Sebastiano, Vittorio; Bao, Gang; Porteus, Matthew H

2014-01-01

SUMMARY Targeted genome editing with engineered nucleases has transformed the ability to introduce precise sequence modifications at almost any site within the genome. A major obstacle to probing the efficiency and consequences of genome editing is that no existing method enables the frequency of different editing events to be simultaneously measured across a cell population at any endogenous genomic locus. We have developed a novel method for quantifying individual genome editing outcomes at any site of interest using single molecule real time (SMRT) DNA sequencing. We show that this approach can be applied at various loci, using multiple engineered nuclease platforms including TALENs, RNA guided endonucleases (CRISPR/Cas9), and ZFNs, and in different cell lines to identify conditions and strategies in which the desired engineering outcome has occurred. This approach facilitates the evaluation of new gene editing technologies and permits sensitive quantification of editing outcomes in almost every experimental system used. PMID:24685129

Virtually Out of This World!

NASA Technical Reports Server (NTRS)

2002-01-01

Ames Research Center granted Reality Capture Technologies (RCT), Inc., a license to further develop NASA's Mars Map software platform. The company incorporated NASA#s innovation into software that uses the Virtual Plant Model (VPM)(TM) to structure, modify, and implement the construction sites of industrial facilities, as well as develop, validate, and train operators on procedures. The VPM orchestrates the exchange of information between engineering, production, and business transaction systems. This enables users to simulate, control, and optimize work processes while increasing the reliability of critical business decisions. Engineers can complete the construction process and test various aspects of it in virtual reality before building the actual structure. With virtual access to and simulation of the construction site, project personnel can manage, access control, and respond to changes on complex constructions more effectively. Engineers can also create operating procedures, training, and documentation. Virtual Plant Model(TM) is a trademark of Reality Capture Technologies, Inc.

Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting

NASA Astrophysics Data System (ADS)

Zhu, Yuanjun; Li, Ruyi; Lin, Yuan; Shui, Mengyang; Liu, Xiaoyan; Chen, Huan; Wang, Yinye

2016-07-01

Targeted delivery of antithrombotic drugs centralizes the effects in the thrombosis site and reduces the hemorrhage side effects in uninjured vessels. We have recently reported that the platelet-targeting factor Xa (FXa) inhibitors, constructed by engineering one Arg-Gly-Asp (RGD) motif into Ancylostoma caninum anticoagulant peptide 5 (AcAP5), can reduce the risk of systemic bleeding than non-targeted AcAP5 in mouse arterial injury model. Increasing the number of platelet-binding sites of FXa inhibitors may facilitate their adhesion to activated platelets, and further lower the bleeding risks. For this purpose, we introduced three RGD motifs into AcAP5 to generate a variant NR4 containing three platelet-binding sites. NR4 reserved its inherent anti-FXa activity. Protein-protein docking showed that all three RGD motifs were capable of binding to platelet receptor αIIbβ3. Molecular dynamics simulation demonstrated that NR4 has more opportunities to interact with αIIbβ3 than single-RGD-containing NR3. Flow cytometry analysis and rat arterial thrombosis model further confirmed that NR4 possesses enhanced platelet targeting activity. Moreover, NR4-treated mice showed a trend toward less tail bleeding time than NR3-treated mice in carotid artery endothelium injury model. Therefore, our data suggest that engineering multiple binding sites in one recombinant protein is a useful tool to improve its platelet-targeting efficiency.

Energy systems research and development for petroleum refineries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robertson, J.L.

1982-08-01

For the past several years, Exxon Reasearch and Engineering has carried out a specific RandD program aimed at improving refinery energy efficiency through optimization of energy systems. Energy systems include: steam/power systems, heat exchange systems including hot oil and hot water belts and fuel systems, as well as some of the processes. This paper will describe the three major thrusts of this program which are: development of methods to support Site Energy Survey activities; development of energy management methods; and energy system optimization, which includes development of consistent, realistic, economic incentives for energy system improvements. Project selection criteria will alsomore » be discussed. The technique of a site energy survey will also be described briefly.« less

78 FR 26423 - Railroad Safety Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

... Engineering and System Safety Task Forces. This agenda is subject to change, including the possible addition.... See the RSAC Web site for details on prior RSAC activities and pending tasks at: http://rsac.fra.dot...

Current-day matters of administration and law in the field of high-rise construction

NASA Astrophysics Data System (ADS)

Voskresenskaya, Elena; Snetkov, Vitaly; Tebryaev, Alexander

2018-03-01

The article touches upon main reasons for high-rise construction: increase in energy consumption and limited availability of site in the big cities of Russia. Increase in energy consumption is related with construction, transportation and applying of ventilation and air conditioning systems. Nowadays, there are developed a lot of design and engineer solutions, that include autonomous systems as well as passive methods with low energy consumption rate, which are interrelated with local climate conditions. Certain architectural solutions contribute to energy consumption decrease: building orientation with respect to the cardinal directions, taking into account the prevailing cold wind directions, maximum glazing of the southern facades and minimum glazing of the northern ones, what plays a big role in hard climate conditions. Limited availability of site for construction in the big cities resulted in rapid development of the high-rise construction, which today prevails in terms of quantitative indicators of civil engineering.

A systems approach for designing a radio station layout for the U.S. National Airspace

NASA Astrophysics Data System (ADS)

Boci, Erton S.

Today's National Airspace System (NAS) is managed using an aging surveillance radar system. Current radar technology is not adequate to sustain the rapid growth of the commercial, civil, and federal aviation sectors and cannot be adapted to use emerging 21st century airspace surveillance technologies. With 87,000 flights to manage per day, America's ground based radar system has hit a growth ceiling. Consequently, the FAA has embarked on a broad-reaching effort called the Next Generation Air Transportation System (NextGen) that seeks to transform today's aviation airspace management and ensure increased safety and capacity in our NAS. This dissertation presents a systems approach to Service Volume (SV) engineering, a relatively new field of engineering that has emerged in support of the FAA's Automatic Dependent Surveillance -- Broadcast (ADS-B) Air Traffic Modernization Program. SV Engineering is responsible for radio station layout design that would provide the required radio frequency (RF) coverage over a set of Service Volumes, each which represents a section of controlled airspace that is served by a particular air control facility or service. The radio station layout must be optimized to meet system performance, safety, and interference requirements while minimizing the number of radio station sites required to provide RF coverage of the entire airspace of the Unites States. The interference level requirements at the victim (of interference) receivers are the most important and stringent requirements imposed on the ADS-B radio station layout and configuration. In this dissertation, we show a novel and practical way to achieve this optimality by developing and employing several key techniques such as such as reverse radio line-of-site (RLOS) and complex entity-relationship modeling, to address the greater challenges of engineering this complex system. Given that numerous NAS radar facilities are clustered together in relative close proximity to each other, we can optimize site selection placement for coverage through a process of coverage aggregation if we anticipate and leverage the emergent properties that manifest from their aggregation. This optimization process across the NAS significantly reduces the total number of RS sites necessary for complete coverage. Furthermore, in this dissertation, we show the approach taken to develop an entity-relationship model that will support the data capture and distribution of RF SV design. We utilize the CORE software environment to develop a geospatial / RF design entityrelationship (ER) model schema that in conjunction with development of several advanced parsers facilitates effective data management and the communication of complex model logical and parametric detail. Authors note: While the modern standard for scientific papers is to use the International System of Units (SI), this paper was written using the units of measure of the civilian aviation domain to make this research accessible and useful to that community.

On multi-site damage identification using single-site training data

NASA Astrophysics Data System (ADS)

Barthorpe, R. J.; Manson, G.; Worden, K.

2017-11-01

This paper proposes a methodology for developing multi-site damage location systems for engineering structures that can be trained using single-site damaged state data only. The methodology involves training a sequence of binary classifiers based upon single-site damage data and combining the developed classifiers into a robust multi-class damage locator. In this way, the multi-site damage identification problem may be decomposed into a sequence of binary decisions. In this paper Support Vector Classifiers are adopted as the means of making these binary decisions. The proposed methodology represents an advancement on the state of the art in the field of multi-site damage identification which require either: (1) full damaged state data from single- and multi-site damage cases or (2) the development of a physics-based model to make multi-site model predictions. The potential benefit of the proposed methodology is that a significantly reduced number of recorded damage states may be required in order to train a multi-site damage locator without recourse to physics-based model predictions. In this paper it is first demonstrated that Support Vector Classification represents an appropriate approach to the multi-site damage location problem, with methods for combining binary classifiers discussed. Next, the proposed methodology is demonstrated and evaluated through application to a real engineering structure - a Piper Tomahawk trainer aircraft wing - with its performance compared to classifiers trained using the full damaged-state dataset.

Integrated Propulsion Data System Public Web Site

NASA Technical Reports Server (NTRS)

Hamilton, Kimberly

2001-01-01

The Integrated Propulsion Data System's (IPDS) focus is to provide technologically-advanced philosophies of doing business at SSC that will enhance the existing operations, engineering and management strategies and provide insight and metrics to assess their daily impacts, especially as related to the Propulsion Test Directorate testing scenarios for the 21st Century.

78 FR 28288 - Nissan North America, Inc., Grant of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... documents log onto the Federal Docket Management System (FDMS) Web site at: http://www.regulations.gov... National Headquarters Building in Franklin, Tennessee. The building houses mostly business personnel (sales marketing, finance) and not design engineers that would have special understanding of the air bag systems...

Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.

PubMed

Schmidt, Karin; Gardill, Bernd R; Kern, Alina; Kirchweger, Peter; Börsch, Michael; Muller, Yves A

2018-05-14

The allosteric interplay between distant functional sites present in a single protein provides for one of the most important regulatory mechanisms in biological systems. While the design of ligand-binding sites into proteins remains challenging, this holds even truer for the coupling of a newly engineered binding site to an allosteric mechanism that regulates the ligand affinity. Here it is shown how computational design algorithms enabled the introduction of doxycycline- and doxorubicin-binding sites into the serine proteinase inhibitor (serpin) family member α1-antichymotrypsin. Further engineering allowed exploitation of the proteinase-triggered serpin-typical S-to-R transition to modulate the ligand affinities. These design variants follow strategies observed in naturally occurring plasma globulins that allow for the targeted delivery of hormones in the blood. By analogy, we propose that the variants described in the present study could be further developed to allow for the delivery of the antibiotic doxycycline and the anticancer compound doxorubicin to tissues/locations that express specific proteinases, such as bacterial infection sites or tumor cells secreting matrix metalloproteinases.

Photoactivable antibody binding protein: site-selective and covalent coupling of antibody.

PubMed

Jung, Yongwon; Lee, Jeong Min; Kim, Jung-won; Yoon, Jeongwon; Cho, Hyunmin; Chung, Bong Hyun

2009-02-01

Here we report new photoactivable antibody binding proteins, which site-selectively capture antibodies and form covalent conjugates with captured antibodies upon irradiation. The proteins allow the site-selective tagging and/or immobilization of antibodies with a highly preferred orientation and omit the need for prior antibody modifications. The minimal Fc-binding domain of protein G, a widely used antibody binding protein, was genetically and chemically engineered to contain a site-specific photo cross-linker, benzophenone. In addition, the domain was further mutated to have an enhanced Fc-targeting ability. This small engineered protein was successfully cross-linked only to the Fc region of the antibody without any nonspecific reactivity. SPR analysis indicated that antibodies can be site-selectively biotinylated through the present photoactivable protein. Furthermore, the system enabled light-induced covalent immobilization of antibodies directly on various solid surfaces, such as those of glass slides, gold chips, and small particles. Antibody coupling via photoactivable antibody binding proteins overcomes several limitations of conventional approaches, such as random chemical reactions or reversible protein binding, and offers a versatile tool for the field of immunosensors.

International use of an academic nephrology World Wide Web site: from medical information resource to business tool.

PubMed

Abbott, Kevin C; Oliver, David K; Boal, Thomas R; Gadiyak, Grigorii; Boocks, Carl; Yuan, Christina M; Welch, Paul G; Poropatich, Ronald K

2002-04-01

Studies of the use of the World Wide Web to obtain medical knowledge have largely focused on patients. In particular, neither the international use of academic nephrology World Wide Web sites (websites) as primary information sources nor the use of search engines (and search strategies) to obtain medical information have been described. Visits ("hits") to the Walter Reed Army Medical Center (WRAMC) Nephrology Service website from April 30, 2000, to March 14, 2001, were analyzed for the location of originating source using Webtrends, and search engines (Google, Lycos, etc.) were analyzed manually for search strategies used. From April 30, 2000 to March 14, 2001, the WRAMC Nephrology Service website received 1,007,103 hits and 12,175 visits. These visits were from 33 different countries, and the most frequent regions were Western Europe, Asia, Australia, the Middle East, Pacific Islands, and South America. The most frequent organization using the site was the military Internet system, followed by America Online and automated search programs of online search engines, most commonly Google. The online lecture series was the most frequently visited section of the website. Search strategies used in search engines were extremely technical. The use of "robots" by standard Internet search engines to locate websites, which may be blocked by mandatory registration, has allowed users worldwide to access the WRAMC Nephrology Service website to answer very technical questions. This suggests that it is being used as an alternative to other primary sources of medical information and that the use of mandatory registration may hinder users from finding valuable sites. With current Internet technology, even a single service can become a worldwide information resource without sacrificing its primary customers.

Getting to the top of Google: search engine optimization.

PubMed

Maley, Catherine; Baum, Neil

2010-01-01

Search engine optimization is the process of making your Web site appear at or near the top of popular search engines such as Google, Yahoo, and MSN. This is not done by luck or knowing someone working for the search engines but by understanding the process of how search engines select Web sites for placement on top or on the first page. This article will review the process and provide methods and techniques to use to have your site rated at the top or very near the top.

Recent developments in processing systems for cell and tissue cultures toward therapeutic application.

PubMed

Kino-oka, Masahiro; Taya, Masahito

2009-10-01

Innovative techniques of cell and tissue processing, based on tissue engineering, have been developed for therapeutic applications. Cell expansion and tissue reconstruction through ex vivo cultures are core processes used to produce engineered tissues with sufficient structural integrity and functionality. In manufacturing, strict management against contamination and human error is compelled due to direct use of un-sterilable products and the laboriousness of culture operations, respectively. Therefore, the development of processing systems for cell and tissue cultures is one of the critical issues for ensuring a stable process and quality of therapeutic products. However, the siting criterion of culture systems to date has not been made clear. This review article classifies some of the known processing systems into 'sealed-chamber' and 'sealed-vessel' culture systems based on the difference in their aseptic spaces, and describes the potential advantages of these systems and current states of culture systems, especially those established by Japanese companies. Moreover, on the basis of the guidelines for isolator systems used in aseptic processing for healthcare products, which are issued by the International Organization for Standardization, the siting criterion of the processing systems for cells and tissue cultures is discussed in perspective of manufacturing therapeutic products in consideration of the regulations according to the Good Manufacturing Practice.

SLS Test Stand Site Selection

NASA Technical Reports Server (NTRS)

Crowe, Kathryn; Williams, Michael

2015-01-01

Test site selection is a critical element of the design, development and production of a new system. With the advent of the new Space Launch System (SLS), the National Aeronautics and Space Administration (NASA) had a number of test site selection decisions that needed to be made early enough in the Program to support the planned Launch Readiness Date (LRD). This case study focuses on decisions that needed to be made in 2011 and 2012 in preparation for the April 2013 DPMC decision about where to execute the Main Propulsion Test that is commonly referred to as "Green Run." Those decisions relied upon cooperative analysis between the Program, the Test Lab and Center Operations. The SLS is a human spaceflight vehicle designed to carry a crew farther into space than humans have previously flown. The vehicle consists of four parts: the crew capsule, the upper stage, the core stage, and the first stage solid rocket boosters. The crew capsule carries the astronauts, while the upper stage, the core stage, and solid rocket boosters provide thrust for the vehicle. In other words, the stages provide the "lift" part of the lift vehicle. In conjunction with the solid rocket boosters, the core stage provides the initial "get-off-the-ground" thrust to the vehicle. The ignition of the four core stage engines and two solid rocket boosters is the first step in the launch portion of the mission. The solid rocket boosters burn out after about 2 minutes of flight, and are then jettisoned. The core stage provides thrust until the vehicle reaches a specific altitude and speed, at which point the core stage is shut off and jettisoned, and the upper stage provides vehicle thrust for subsequent mission trajectories. The integrated core stage primarily consists of a liquid oxygen tank, a liquid hydrogen tank, and the four core stage engines. For the SLS program, four RS-25 engines were selected as the four core stage engines. The RS-25 engine is the same engine that was used for Space Shuttle. The test plan for the integrated core stage was broken down into several segments: Component testing, system level testing, and element level testing. In this context, components are items such as valves, controllers, sensors, etc. Systems are items such as an entire engine, a tank, or the outer stage body. The core stage itself is considered to be an element. The rocket engines are also considered an element. At the program level, it was decided to perform a single green run test on the integrated core stage prior to shipment of it to Kennedy Space Center (KSC) for use in the EM-1 test flight of the SLS vehicle. A green run test is the first live fire of the new integrated core stage and engine elements - without boosters of course. The SLS Program had to decide where to perform SLS green run testing.

ENGINEERING BULLETIN: LANDFILL COVERS

EPA Science Inventory

Landfill covers are used at Superfund sites to minimize surface water infiltration and control gas migration. In many cases covers are used in conjunction with other waste treatment technologies, such as slurry walls, ground water pump-and-treat systems, and gas collection. This ...

An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.

PubMed

Bland, Michael J; Ducos-Galand, Magaly; Val, Marie-Eve; Mazel, Didier

2017-07-14

Direct manipulation of the genome is a widespread technique for genetic studies and synthetic biology applications. The tyrosine and serine site-specific recombination systems of bacteriophages HK022 and ΦC31 are widely used for stable directional exchange and relocation of DNA sequences, making them valuable tools in these contexts. We have developed site-specific recombination tools that allow the direct selection of recombination events by embedding the attB site from each system within the β-lactamase resistance coding sequence (bla). The HK and ΦC31 tools were developed by placing the attB sites from each system into the signal peptide cleavage site coding sequence of bla. All possible open reading frames (ORFs) were inserted and tested for recombination efficiency and bla activity. Efficient recombination was observed for all tested ORFs (3 for HK, 6 for ΦC31) as shown through a cointegrate formation assay. The bla gene with the embedded attB site was functional for eight of the nine constructs tested. The HK/ΦC31 att-bla system offers a simple way to directly select recombination events, thus enhancing the use of site-specific recombination systems for carrying out precise, large-scale DNA manipulation, and adding useful tools to the genetics toolbox. We further show the power and flexibility of bla to be used as a reporter for recombination.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Price, Jeffrey

Solar Turbines Incorporated (Solar), under cooperative agreement number DE-FC26-0CH11049, has conducted development activities to improve the durability of the Mercury 50 combustion system to 30,000 hours life and reduced life cycle costs. This project is part of Advanced Materials in the Advanced Industrial Gas Turbines program in DOE's Office of Distributed Energy. The targeted development engine was the Mercury{trademark} 50 gas turbine, which was developed by Solar under the DOE Advanced Turbine Systems program (DOE contract number DE-FC21-95MC31173). As a generator set, the Mercury 50 is used for distributed power and combined heat and power generation and is designed tomore » achieve 38.5% electrical efficiency, reduced cost of electricity, and single digit emissions. The original program goal was 20,000 hours life, however, this goal was increased to be consistent with Solar's standard 30,000 hour time before overhaul for production engines. Through changes to the combustor design to incorporate effusion cooling in the Generation 3 Mercury 50 engine, which resulted in a drop in the combustor wall temperature, the current standard thermal barrier coated liner was predicted to have 18,000 hours life. With the addition of the advanced materials technology being evaluated under this program, the combustor life is predicted to be over 30,000 hours. The ultimate goal of the program was to demonstrate a fully integrated Mercury 50 combustion system, modified with advanced materials technologies, at a host site for a minimum of 4,000 hours. Solar was the Prime Contractor on the program team, which includes participation of other gas turbine manufacturers, various advanced material and coating suppliers, nationally recognized test laboratories, and multiple industrial end-user field demonstration sites. The program focused on a dual path development route to define an optimum mix of technologies for the Mercury 50 and future gas turbine products. For liner and injector development, multiple concepts including high thermal resistance thermal barrier coatings (TBC), oxide dispersion strengthened (ODS) alloys, continuous fiber ceramic composites (CFCC), and monolithic ceramics were evaluated before down-selection to the most promising candidate materials for field evaluation. Preliminary, component and sub-scale testing was conducted to determine material properties and demonstrate proof-of-concept. Full-scale rig and engine testing was used to validated engine performance prior to field evaluation at a Qualcomm Inc. cogeneration site located in San Diego, California. To ensure that the CFCC liners with the EBC proposed under this program would meet the target life, field evaluations of ceramic matrix composite liners in Centaur{reg_sign} 50 gas turbine engines, which had previously been conducted under the DOE sponsored Ceramic Stationary Gas Turbine program (DE-AC02-92CE40960), was continued under this program at commercial end-user sites under Program Subtask 1A - Extended CFCC Materials Durability Testing. The goal of these field demonstrations was to demonstrate significant component life, with milestones of 20,000 and 30,000 hours. Solar personnel monitor the condition of the liners at the field demonstration sites through periodic borescope inspections and emissions measurements. This program was highly successful at evaluating advanced materials and down-selecting promising solutions for use in gas turbine combustions systems. The addition of the advanced materials technology has enabled the predicted life of the Mercury 50 combustion system to reach 30,000 hours, which is Solar's typical time before overhaul for production engines. In particular, a 40 mil thick advanced Thermal Barrier Coating (TBC) system was selected over various other TBC systems, ODS liners and CFCC liners for the 4,000-hour field evaluation under the program. This advanced TBC is now production bill-of-material at various thicknesses up to 40 mils for all of Solar's advanced backside-cooled combustor liners (Centaur 50, Taurus 60, Mars 100, Taurus 70, Taurus 65, Titan 130, Titan 250 and Mercury 50). This TBC coating system significantly outperformed all other TBC systems evaluated under the program. The initial field unit, with the 40 mil advanced TBC developed under this program, has far exceeded the 4,000-hour requirement of the program, accumulating over 20,000 hours of commercial operation at Qualcomm Inc. in San Diego, CA. The 40 mil advanced TBC remains in excellent condition, with no evidence of chipping or spalling. The engine will continue operation until the unit is due for overhaul at approximately 30,000 hours. The Oxide Dispersion Strengthened (ODS) alloy injector tip testing and evaluation was also successful, however, the ODS injector tip development on this program was terminated, primarily due to the fact that the Mercury 50 injector tip was redesigned (Generation 3) by Combustion Engineering.« less

Improvements in algal lipid production: a systems biology and gene editing approach.

PubMed

Banerjee, Avik; Banerjee, Chiranjib; Negi, Sangeeta; Chang, Jo-Shu; Shukla, Pratyoosh

2018-05-01

In the wake of rising energy demands, microalgae have emerged as potential sources of sustainable and renewable carbon-neutral fuels, such as bio-hydrogen and bio-oil. For rational metabolic engineering, the elucidation of metabolic pathways in fine detail and their manipulation according to requirements is the key to exploiting the use of microalgae. Emergence of site-specific nucleases have revolutionized applied research leading to biotechnological gains. Genome engineering as well as modulation of the endogenous genome with high precision using CRISPR systems is being gradually employed in microalgal research. Further, to optimize and produce better algal platforms, use of systems biology network analysis and integration of omics data is required. This review discusses two important approaches: systems biology and gene editing strategies used on microalgal systems with a focus on biofuel production and sustainable solutions. It also emphasizes that the integration of such systems would contribute and compliment applied research on microalgae. Recent advances in microalgae are discussed, including systems biology, gene editing approaches in lipid bio-synthesis, and antenna engineering. Lastly, it has been attempted here to showcase how CRISPR/Cas systems are a better editing tool than existing techniques that can be utilized for gene modulation and engineering during biofuel production.

Floquet Engineering of Correlated Tunneling in the Bose-Hubbard Model with Ultracold Atoms.

PubMed

Meinert, F; Mark, M J; Lauber, K; Daley, A J; Nägerl, H-C

2016-05-20

We report on the experimental implementation of tunable occupation-dependent tunneling in a Bose-Hubbard system of ultracold atoms via time-periodic modulation of the on-site interaction energy. The tunneling rate is inferred from a time-resolved measurement of the lattice site occupation after a quantum quench. We demonstrate coherent control of the tunneling dynamics in the correlated many-body system, including full suppression of tunneling as predicted within the framework of Floquet theory. We find that the tunneling rate explicitly depends on the atom number difference in neighboring lattice sites. Our results may open up ways to realize artificial gauge fields that feature density dependence with ultracold atoms.

Site dose calculations for the INEEL/TMI-2 storage facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, K.B.

1997-12-01

The U.S. Department of Energy (DOE) is licensing an independent spent-fuel storage installation (ISFSI) for the Three Mile Island unit 2 (TMI-2) core debris to be constructed at the Idaho Chemical Processing Plant (ICPP) site at the Idaho National Engineering and Environmental Laboratory (INEEL) using the NUHOMS spent-fuel storage system. This paper describes the site dose calculations, performed in support of the license application, that estimate exposures both on the site and for members of the public. These calculations are unusual for dry-storage facilities in that they must account for effluents from the system in addition to skyshine from themore » ISFSI. The purpose of the analysis was to demonstrate compliance with the 10 CFR 20 and 10 CFR 72.104 exposure limits.« less

75 FR 34170 - Chrysler Group LLC, Formally Known as Chrysler LLC, Kenosha Engine Plant, Including On-Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... automobile engines. The company reports that workers leased from Caravan Knight Facilities Management, LLC..., Formally Known as Chrysler LLC, Kenosha Engine Plant, Including On-Site Leased Workers From Caravan Knight..., Kenosha Engine Plant, Kenosha, Wisconsin. The notice was published in [[Page 34171

US EPA record of decision review for landfills: Sanitary landfill (740-G), Savannah River Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-06-01

This report presents the results of a review of the US Environmental Protection Agency (EPA) Record of Decision System (RODS) database search conducted to identify Superfund landfill sites where a Record of Decision (ROD) has been prepared by EPA, the States or the US Army Corps of Engineers describing the selected remedy at the site. ROD abstracts from the database were reviewed to identify site information including site type, contaminants of concern, components of the selected remedy, and cleanup goals. Only RODs from landfill sites were evaluated so that the results of the analysis can be used to support themore » remedy selection process for the Sanitary Landfill at the Savannah River Site (SRS).« less

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter.

PubMed

Isalan, M; Klug, A; Choo, Y

2001-07-01

DNA-binding domains with predetermined sequence specificity are engineered by selection of zinc finger modules using phage display, allowing the construction of customized transcription factors. Despite remarkable progress in this field, the available protein-engineering methods are deficient in many respects, thus hampering the applicability of the technique. Here we present a rapid and convenient method that can be used to design zinc finger proteins against a variety of DNA-binding sites. This is based on a pair of pre-made zinc finger phage-display libraries, which are used in parallel to select two DNA-binding domains each of which recognizes given 5 base pair sequences, and whose products are recombined to produce a single protein that recognizes a composite (9 base pair) site of predefined sequence. Engineering using this system can be completed in less than two weeks and yields proteins that bind sequence-specifically to DNA with Kd values in the nanomolar range. To illustrate the technique, we have selected seven different proteins to bind various regions of the human immunodeficiency virus 1 (HIV-1) promoter.

MagLifter Site Investigation and Implementation Strategies

NASA Technical Reports Server (NTRS)

Burke, Pamela; Slaughter, Maynard; Beer, C. Neil

1995-01-01

MagLifter, as defined here, is an advanced, earth-bound catapult system to provide the initial lift for earth orbiting vehicles to reduce or eliminate the need for multistage propulsion, thus reducing the cost of orbital space flight. It is presumed that magnetic levitation will catapult the vehicle to a desired initial velocity sufficient for reaching orbit with the vehicles own engines. Of necessity, the system must be located on and around a mountain with sufficient relief to allow the catapult to accelerate the launch vehicle to a sufficient speed in the desired direction to allow it to reach orbit. Such a mountain site must meet criteria consistent with current and future space launch needs and conditions. It is the purpose of this report to set forth preliminary criteria for choosing a suitable maglifter site. The report is divided into four major sections: (1) Assumed Launch System and Flight Vehicle Characteristics; (2) Task 1.A - Initial Site Selection Criteria; (3) Conclusions; and (4) Appendix - Phases of the Site Selection Process.

Applications of the DOE/NASA wind turbine engineering information system

NASA Technical Reports Server (NTRS)

Neustadter, H. E.; Spera, D. A.

1981-01-01

A statistical analysis of data obtained from the Technology and Engineering Information Systems was made. The systems analyzed consist of the following elements: (1) sensors which measure critical parameters (e.g., wind speed and direction, output power, blade loads and component vibrations); (2) remote multiplexing units (RMUs) on each wind turbine which frequency-modulate, multiplex and transmit sensor outputs; (3) on-site instrumentation to record, process and display the sensor output; and (4) statistical analysis of data. Two examples of the capabilities of these systems are presented. The first illustrates the standardized format for application of statistical analysis to each directly measured parameter. The second shows the use of a model to estimate the variability of the rotor thrust loading, which is a derived parameter.

Strategie de commande pour un systeme hybride eolien diesel avec stockage d'air comprime =

NASA Astrophysics Data System (ADS)

Perron, Francois

The electrical energy provisioning of isolated sites requires a steady supply of diesel fuel which represents a significant logistical and economic burden. The main objective of this project is to propose a control strategy for an air storage wind diesel hybrid system (SHEDAC) and to evaluate its fuel reduction potential for a given site. This research is conducted within a result validation context. It encompasses the combination of a wind speed and load modeling on an isolated village including a SHEDAC model and the results are tailored to this specific site. Because the pneumatic hybridation of an otherwise unmodified diesel engine is at the core of the suggested approach, a detailed thermodynamic model of the engine behavior as well as a comprehensive friction analysis of its components is presented. Simulation results show that the energy recovery from the pneumatic pathway of the motor is counter productive and an alternative configuration involving an air turbine is proposed. The study of this modified SHEDAC is performed with a specific focus on the efficiency of the compressed air recovery path in an effort to make it as general as possible. Fuel consumption reductions of 49% could be achieved with this system while the recovery efficiency was etaair = 0.5.

Field Testing of Environmentally Friendly Drilling System

DOE Office of Scientific and Technical Information (OSTI.GOV)

David Burnett

2009-05-31

The Environmentally Friendly Drilling (EFD) program addresses new low-impact technology that reduces the footprint of drilling activities, integrates light weight drilling rigs with reduced emission engine packages, addresses on-site waste management, optimizes the systems to fit the needs of a specific development sites and provides stewardship of the environment. In addition, the program includes industry, the public, environmental organizations, and elected officials in a collaboration that addresses concerns on development of unconventional natural gas resources in environmentally sensitive areas. The EFD program provides the fundamentals to result in greater access, reasonable regulatory controls, lower development cost and reduction of themore » environmental footprint associated with operations for unconventional natural gas. Industry Sponsors have supported the program with significant financial and technical support. This final report compendium is organized into segments corresponding directly with the DOE approved scope of work for the term 2005-2009 (10 Sections). Each specific project is defined by (a) its goals, (b) its deliverable, and (c) its future direction. A web site has been established that contains all of these detailed engineering reports produced with their efforts. The goals of the project are to (1) identify critical enabling technologies for a prototype low-impact drilling system, (2) test the prototype systems in field laboratories, and (3) demonstrate the advanced technology to show how these practices would benefit the environment.« less

Case Studies in Application of System Engineering Practices to Capstone Projects

NASA Technical Reports Server (NTRS)

Murphy, Gloria; vanSusante, Paul; Carmen, Christina; Morris, Tommy; Schmidt, Peter; Zalewski, Janusz

2011-01-01

The Exploration Systems Mission Directorate (ESMD) of the National Aeronautics and Space Administration (NASA) sponsors a faculty fellowship program that engages researchers with interests aligned with current ESMD development programs. The faculty-members are committed to run a capstone senior design project based- on the materials and experience gained during the fellowship. For the 2010 - 2011 academic year, 5 projects were approved. These projects are in the areas of mechanical and electrical hardware design and optimization, fault prediction and extra planetary civil site preparation. This work summarizes the projects, describes the student teams performing the work, and comments on the integration of Systems Engineering principles into the projects, as well as the affected course curriculums.

System engineering and science projects: lessons from MeerKAT

NASA Astrophysics Data System (ADS)

Kapp, Francois

2016-08-01

The Square Kilometre Array (SKA) is a large science project planning to commence construction of the world's largest Radio Telescope after 2018. MeerKAT is one of the precursor projects to the SKA, based on the same site that will host the SKA Mid array in the central Karoo area of South Africa. From the perspective of signal processing hardware development, we analyse the challenges that MeerKAT encountered and extrapolate them to SKA in order to prepare the System Engineering and Project Management methods that could contribute to a successful completion of SKA. Using the MeerKAT Digitiser, Correlator/Beamformer and Time and Frequency Reference Systems as an example, we will trace the risk profile and subtle differences in engineering approaches of these systems over time and show the effects of varying levels of System Engineering rigour on the evolution of their risk profiles. It will be shown that the most rigorous application of System Engineering discipline resulted in the most substantial reduction in risk over time. Since the challenges faced by SKA are not limited to that of MeerKAT, we also look into how that translates to a system development where there is substantial complexity in both the created system as well as the creating system. Since the SKA will be designed and constructed by consortia made up from the ten member countries, there are many additional complexities to the organisation creating the system - a challenge the MeerKAT project did not encounter. Factors outside of engineering, for instance procurement models and political interests, also play a more significant role, and add to the project risks of SKA when compared to MeerKAT.

A-3 Groundbreaking Ceremony

NASA Image and Video Library

2007-08-23

NASA officials and government leaders participated in a groundbreaking event for a new rocket engine test stand at NASA's Stennis Space Center, Miss. Pictured (left to right) are Deputy Associate Administrator for Exploration Systems Doug Cooke, Pratt & Whitney Rocketdyne President Jim Maser, Stennis Space Center Director Richard Gilbrech, NASA Associate Administrator for Exploration Systems Scott Horowitz, NASA Deputy Administrator Shana Dale, Mississippi Gov. Haley Barbour, Sen. Thad Cochran, Sen. Trent Lott, Rep. Gene Taylor, SSC's Deputy Director Gene Goldman, and SSC's A-3 Project Manager Lonnie Dutreix. Stennis' A-3 Test Stand will provide altitude testing for NASA's developing J-2X engine. That engine will power the upper stages of NASA's Ares I and Ares V rockets. A-3 is the first large test stand to be built at SSC since the site's inception in the 1960s.

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

PubMed Central

Lee, Ciaran M; Cradick, Thomas J; Fine, Eli J; Bao, Gang

2016-01-01

The rapid advancement in targeted genome editing using engineered nucleases such as ZFNs, TALENs, and CRISPR/Cas9 systems has resulted in a suite of powerful methods that allows researchers to target any genomic locus of interest. A complementary set of design tools has been developed to aid researchers with nuclease design, target site selection, and experimental validation. Here, we review the various tools available for target selection in designing engineered nucleases, and for quantifying nuclease activity and specificity, including web-based search tools and experimental methods. We also elucidate challenges in target selection, especially in predicting off-target effects, and discuss future directions in precision genome editing and its applications. PMID:26750397

Transformable Rhodobacter strains, method for producing transformable Rhodobacter strains

DOEpatents

Laible, Philip D.; Hanson, Deborah K.

2018-05-08

The invention provides an organism for expressing foreign DNA, the organism engineered to accept standard DNA carriers. The genome of the organism codes for intracytoplasmic membranes and features an interruption in at least one of the genes coding for restriction enzymes. Further provided is a system for producing biological materials comprising: selecting a vehicle to carry DNA which codes for the biological materials; determining sites on the vehicle's DNA sequence susceptible to restriction enzyme cleavage; choosing an organism to accept the vehicle based on that organism not acting upon at least one of said vehicle's sites; engineering said vehicle to contain said DNA; thereby creating a synthetic vector; and causing the synthetic vector to enter the organism so as cause expression of said DNA.

2016 Milwaukee Engineering Research Conference | College of Engineering &

Science.gov Websites

Applied Science A B C D E F G H I J K L M N O P Q R S T U V W X Y Z D2L PAWS Email My UW Visit Apply Give to UWM Jobs D2L PAWS Email My UW-System University of Wisconsin-Milwaukee College Olympiad Girls Who Code Club FIRST Tech Challenge NSF I-Corps Site of Southeastern Wisconsin UW-Milwaukee

View from west to east of PAR site resident engineer's ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View from west to east of PAR site resident engineer's office building (REOB) - Stanley R. Mickelsen Safeguard Complex, Resident Engineers Office Building, Southeast of intersection of PAR Access Road & Fourth Avenue, Nekoma, Cavalier County, ND

Advances and Computational Tools towards Predictable Design in Biological Engineering

PubMed Central

2014-01-01

The design process of complex systems in all the fields of engineering requires a set of quantitatively characterized components and a method to predict the output of systems composed by such elements. This strategy relies on the modularity of the used components or the prediction of their context-dependent behaviour, when parts functioning depends on the specific context. Mathematical models usually support the whole process by guiding the selection of parts and by predicting the output of interconnected systems. Such bottom-up design process cannot be trivially adopted for biological systems engineering, since parts function is hard to predict when components are reused in different contexts. This issue and the intrinsic complexity of living systems limit the capability of synthetic biologists to predict the quantitative behaviour of biological systems. The high potential of synthetic biology strongly depends on the capability of mastering this issue. This review discusses the predictability issues of basic biological parts (promoters, ribosome binding sites, coding sequences, transcriptional terminators, and plasmids) when used to engineer simple and complex gene expression systems in Escherichia coli. A comparison between bottom-up and trial-and-error approaches is performed for all the discussed elements and mathematical models supporting the prediction of parts behaviour are illustrated. PMID:25161694

Engineering Information Infrastructure for Product Lifecycle Managment

NASA Astrophysics Data System (ADS)

Kimura, Fumihiko

For proper management of total product life cycle, it is fundamentally important to systematize design and engineering information about product systems. For example, maintenance operation could be more efficiently performed, if appropriate parts design information is available at the maintenance site. Such information shall be available as an information infrastructure for various kinds of engineering operations, and it should be easily accessible during the whole product life cycle, such as transportation, marketing, usage, repair/upgrade, take-back and recycling/disposal. Different from the traditional engineering database, life cycle support information has several characteristic requirements, such as flexible extensibility, distributed architecture, multiple viewpoints, long-time archiving, and product usage information, etc. Basic approaches for managing engineering information infrastructure are investigated, and various information contents and associated life cycle applications are discussed.

Space Food Systems Laboratory

NASA Technical Reports Server (NTRS)

Perchonok, Michele; Russo, Dane M. (Technical Monitor)

2001-01-01

The Space Food Systems Laboratory (SFSL) is a multipurpose laboratory responsible for space food and package research and development. It is located on-site at Johnson Space Center in Building 17. The facility supports the development of flight food, menus, packaging and food related hardware for Shuttle, International Space Station, and Advanced Life Support food systems. All foods used to support NASA ground tests and/or missions must meet the highest standards before they are 'accepted' for use on actual space flights. The foods are evaluated for nutritional content, sensory acceptability, safety, storage and shelf life, and suitability for use in micro-gravity. The food packaging is also tested to determine its functionality and suitability for use in space. Food Scientist, Registered Dieticians, Packaging Engineers, Food Systems Engineers, and Technicians staff the Space Food Systems Laboratory.

75 FR 5147 - Global Engine Manufacturing Alliance a Subsidiary of the Chrysler Group LLC Including On-Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-01

... engaged in the production of 4-cylinder engines for automobiles. The company reports that on-site leased... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-71,581] Global Engine... Adjustment Assistance on September 22, 2009, applicable to workers of Global Engine Manufacturing Alliance, a...

Site Characterization Report (Building 202). Volume 2. Appendicies A-H.

DTIC Science & Technology

1996-04-01

Bionetics,Groundwater and Wells, Environmental Science and Engineering, Inc., Installation Assessment of ERADCOM Activities, Environmental Science and...Engineering, Inc., Plan for the Assessment of Contamination at Woodbridge Research Facility, Environmental Science and Engineering, Inc., Remedial...Action Plan for the Woodbridge Research Facility PCB Disposal Site, Environmental Science and Engineering, Inc., Remedial Investigation and

A Global Survey of Deep Underground Facilities; Examples of Geotechnical and Engineering Capabilities, Achievements, Challenges (Mines, Shafts, Tunnels, Boreholes, Sites and Underground Facilities for Nuclear Waste and Physics R&D): A Guide to Interactive Global Map Layers, Table Database, References and Notes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tynan, Mark C.; Russell, Glenn P.; Perry, Frank V.

These associated tables, references, notes, and report present a synthesis of some notable geotechnical and engineering information used to create four interactive layer maps for selected: 1) deep mines and shafts; 2) existing, considered or planned radioactive waste management deep underground studies or disposal facilities 3) deep large diameter boreholes, and 4) physics underground laboratories and facilities from around the world. These data are intended to facilitate user access to basic information and references regarding “deep underground” facilities, history, activities, and plans. In general, the interactive maps and database provide each facility’s approximate site location, geology, and engineered features (e.g.:more » access, geometry, depth, diameter, year of operations, groundwater, lithology, host unit name and age, basin; operator, management organization, geographic data, nearby cultural features, other). Although the survey is not comprehensive, it is representative of many of the significant existing and historical underground facilities discussed in the literature addressing radioactive waste management and deep mined geologic disposal safety systems. The global survey is intended to support and to inform: 1) interested parties and decision makers; 2) radioactive waste disposal and siting option evaluations, and 3) safety case development applicable to any mined geologic disposal facility as a demonstration of historical and current engineering and geotechnical capabilities available for use in deep underground facility siting, planning, construction, operations and monitoring.« less

Commonality of Ground Systems in Launch Operations

NASA Technical Reports Server (NTRS)

Quinn, Shawn M.

2008-01-01

NASA is examining the utility of requiring a certain degree of commonality in both flight and ground systems in the Constellation Program. While the benefits of commonality seem obvious in terms of minimizing upfront development and long-term operations and maintenance costs, success in real, large-scale engineering systems used to support launch operations is relatively unknown. A broad literature review conducted for this paper did not yield a single paper specifically addressing the application of commonality for ground systems at any launch site in the United States or abroad. This paper provides a broad overview of the ground systems, captures historical and current application of commonality at the launch site, and offers suggestions for additional research to further develop commonality approaches.

Integrated platform for optimized solar PV system design and engineering plan set generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adeyemo, Samuel

2015-12-30

The Aurora team has developed software that allows users to quickly generate a three-dimensional model for a building, with a corresponding irradiance map, from any two-dimensional image with associated geo-coordinates. The purpose of this project is to build upon that technology by developing and distributing to solar installers a software platform that automatically retrieves engineering, financial and geographic data for a specific site, and quickly generates an optimal customer proposal and corresponding engineering plans for that site. At the end of the project, Aurora’s optimization platform would have been used to make at least one thousand proposals from at leastmore » ten unique solar installation companies, two of whom would sign economically viable contracts to use the software. Furthermore, Aurora’s algorithms would be tested to show that in at least seventy percent of cases, Aurora automatically generated a design equivalent to or better than what a human could have done manually. A ‘better’ design is one that generates more energy for the same cost, or that generates a higher return on investment, while complying with all site-specific aesthetic, electrical and spatial requirements.« less

An integrated CRISPR Bombyx mori genome editing system with improved efficiency and expanded target sites.

PubMed

Ma, Sanyuan; Liu, Yue; Liu, Yuanyuan; Chang, Jiasong; Zhang, Tong; Wang, Xiaogang; Shi, Run; Lu, Wei; Xia, Xiaojuan; Zhao, Ping; Xia, Qingyou

2017-04-01

Genome editing enabled unprecedented new opportunities for targeted genomic engineering of a wide variety of organisms ranging from microbes, plants, animals and even human embryos. The serial establishing and rapid applications of genome editing tools significantly accelerated Bombyx mori (B. mori) research during the past years. However, the only CRISPR system in B. mori was the commonly used SpCas9, which only recognize target sites containing NGG PAM sequence. In the present study, we first improve the efficiency of our previous established SpCas9 system by 3.5 folds. The improved high efficiency was also observed at several loci in both BmNs cells and B. mori embryos. Then to expand the target sites, we showed that two newly discovered CRISPR system, SaCas9 and AsCpf1, could also induce highly efficient site-specific genome editing in BmNs cells, and constructed an integrated CRISPR system. Genome-wide analysis of targetable sites was further conducted and showed that the integrated system cover 69,144,399 sites in B. mori genome, and one site could be found in every 6.5 bp. The efficiency and resolution of this CRISPR platform will probably accelerate both fundamental researches and applicable studies in B. mori, and perhaps other insects. Copyright © 2017 Elsevier Ltd. All rights reserved.

Modeling the Effects of Ice Accretion on the Low Pressure Compressor and the Overall Turbofan Engine System Performance

NASA Technical Reports Server (NTRS)

Veres, Joseph P.; Jorgenson, Philip C. E.; Wright, William B.

2011-01-01

The focus of this study is on utilizing a mean line compressor flow analysis code coupled to an engine system thermodynamic code, to estimate the effects of ice accretion on the low pressure compressor, and quantifying its effects on the engine system throughout a notional flight trajectory. In this paper a temperature range in which engine icing would occur was assumed. This provided a mechanism to locate potential component icing sites and allow the computational tools to add blockages due to ice accretion in a parametric fashion. Ultimately the location and level of blockage due to icing would be provided by an ice accretion code. To proceed, an engine system modeling code and a mean line compressor flow analysis code were utilized to calculate the flow conditions in the fan-core and low pressure compressor and to identify potential locations within the compressor where ice may accrete. In this study, an "additional blockage" due to the accretion of ice on the metal surfaces, has been added to the baseline aerodynamic blockage due to boundary layer, as well as the blade metal blockage. Once the potential locations of ice accretion are identified, the levels of additional blockage due to accretion were parametrically varied to estimate the effects on the low pressure compressor blade row performance operating within the engine system environment. This study includes detailed analysis of compressor and engine performance during cruise and descent operating conditions at several altitudes within the notional flight trajectory. The purpose of this effort is to develop the computer codes to provide a predictive capability to forecast the onset of engine icing events, such that they could ultimately help in the avoidance of these events.

Foredune Classification and Storm Response: Automated Analysis of Terrestrial Lidar DEMs

DTIC Science & Technology

2015-06-15

since Hurricane Sandy. 041 20/3/2015 4 Figure 1. A. The study site in Duck , NC showing the alongshore coordinates of the local coordinate...waves on March 10: Hs = 4.8 m at 16 sec Coastal Lidar and Radar Imaging System (CLARIS) Nor’easter Storm Conditions Study Site: Duck , NC...Engineer Research and Development Center, Coastal & Hydraulics Laboratory, Coastal Observation & Analysis Branch, 1261 Duck Rd, Duck , NC 27949, USA

Permafrost Ecosystem Warming Prototype: Installation, Operation, and Initial Site Characterization

DTIC Science & Technology

2013-11-01

report Approved for public release; distribution is unlimited. Prepared for US Army Corps of Engineers Washington , DC 20314-1000 Monitored by...in 3 m diameter plots in a temperate deciduous forest. To further develop the prototype for an arctic climate, a similar test system was installed...growth trees and shrubs. The site was chosen because of its permafrost characteristics, ease of access, and its close proximity to the CRREL Fairbanks

Evaluation of Subsurface Engineered Barriers at Waste Sites Volumes 1 and 2

EPA Pesticide Factsheets

This report provides the U.S. Environmental Protection Agency’s (EPA) waste programs with a national retrospective analysis of barrier field performance, as well as information that useful in developing guidance on the use and evaluation of barrier systems

Adsorption-based Treatment Systems for Removing Chemical Vapors from Indoor Air

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Engineering Issue Papers (EIPs) are a series of technology transfer documents that summarize the latest information on selected waste treatment and site remediation technologies and related issues. EIPs are designed to help remedial ...

76 FR 4744 - Bentley Motors, Inc., Grant of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... Federal Docket Management System Web site at: http://www.regulations.gov/ . Then follow the online search..., when the engine cover is removed the screw is still hidden down a small dark guide hole, so the screw...

Research and Technology

NASA Technical Reports Server (NTRS)

1987-01-01

Selected achievements at the Ames-Moffett and Ames-Dryden sites of the Ames Research Center are illustrated. The challenging work that was accomplished in the past year is presented for the following areas: engineering and technical services, aerospace systems, flight operations and research, aerophysics, and space research.

Lunar surface vehicle model competition

NASA Technical Reports Server (NTRS)

1990-01-01

During Fall and Winter quarters, Georgia Tech's School of Mechanical Engineering students designed machines and devices related to Lunar Base construction tasks. These include joint projects with Textile Engineering students. Topics studied included lunar environment simulator via drop tower technology, lunar rated fasteners, lunar habitat shelter, design of a lunar surface trenching machine, lunar support system, lunar worksite illumination (daytime), lunar regolith bagging system, sunlight diffusing tent for lunar worksite, service apparatus for lunar launch vehicles, lunar communication/power cables and teleoperated deployment machine, lunar regolith bag collection and emplacement device, soil stabilization mat for lunar launch/landing site, lunar rated fastening systems for robotic implementation, lunar surface cable/conduit and automated deployment system, lunar regolith bagging system, and lunar rated fasteners and fastening systems. A special topics team of five Spring quarter students designed and constructed a remotely controlled crane implement for the SKITTER model.

Operational modes, health, and status monitoring

NASA Astrophysics Data System (ADS)

Taljaard, Corrie

2016-08-01

System Engineers must fully understand the system, its support system and operational environment to optimise the design. Operations and Support Managers must also identify the correct metrics to measure the performance and to manage the operations and support organisation. Reliability Engineering and Support Analysis provide methods to design a Support System and to optimise the Availability of a complex system. Availability modelling and Failure Analysis during the design is intended to influence the design and to develop an optimum maintenance plan for a system. The remote site locations of the SKA Telescopes place emphasis on availability, failure identification and fault isolation. This paper discusses the use of Failure Analysis and a Support Database to design a Support and Maintenance plan for the SKA Telescopes. It also describes the use of modelling to develop an availability dashboard and performance metrics.

76 FR 22729 - Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plant #1, Including On-Site Leased...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-22

..., Power Train Division, Mack Avenue Engine Plant 1, Including On-Site Leased Workers From Caravan Knight..., applicable to workers of Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plant 1, including on... all workers of Chrysler LLC, Mack Avenue Engine Plants 1 & 2, Power Train Division, Detroit, Michigan...

Video conferencing made easy

NASA Technical Reports Server (NTRS)

Larsen, D. Gail; Schwieder, Paul R.

1993-01-01

Network video conferencing is advancing rapidly throughout the nation, and the Idaho National Engineering Laboratory (INEL), a Department of Energy (DOE) facility, is at the forefront of the development. Engineers at INEL/EG&G designed and installed a very unique DOE videoconferencing system, offering many outstanding features, that include true multipoint conferencing, user-friendly design and operation with no full-time operators required, and the potential for cost effective expansion of the system. One area where INEL/EG&G engineers made a significant contribution to video conferencing was in the development of effective, user-friendly, end station driven scheduling software. A PC at each user site is used to schedule conferences via a windows package. This software interface provides information to the users concerning conference availability, scheduling, initiation, and termination. The menus are 'mouse' controlled. Once a conference is scheduled, a workstation at the hubs monitors the network to initiate all scheduled conferences. No active operator participation is required once a user schedules a conference through the local PC; the workstation automatically initiates and terminates the conference as scheduled. As each conference is scheduled, hard copy notification is also printed at each participating site. Video conferencing is the wave of the future. The use of these user-friendly systems will save millions in lost productivity and travel cost throughout the nation. The ease of operation and conference scheduling will play a key role on the extent industry uses this new technology. The INEL/EG&G has developed a prototype scheduling system for both commercial and federal government use.

Video conferencing made easy

NASA Astrophysics Data System (ADS)

Larsen, D. Gail; Schwieder, Paul R.

1993-02-01

Network video conferencing is advancing rapidly throughout the nation, and the Idaho National Engineering Laboratory (INEL), a Department of Energy (DOE) facility, is at the forefront of the development. Engineers at INEL/EG&G designed and installed a very unique DOE videoconferencing system, offering many outstanding features, that include true multipoint conferencing, user-friendly design and operation with no full-time operators required, and the potential for cost effective expansion of the system. One area where INEL/EG&G engineers made a significant contribution to video conferencing was in the development of effective, user-friendly, end station driven scheduling software. A PC at each user site is used to schedule conferences via a windows package. This software interface provides information to the users concerning conference availability, scheduling, initiation, and termination. The menus are 'mouse' controlled. Once a conference is scheduled, a workstation at the hubs monitors the network to initiate all scheduled conferences. No active operator participation is required once a user schedules a conference through the local PC; the workstation automatically initiates and terminates the conference as scheduled. As each conference is scheduled, hard copy notification is also printed at each participating site. Video conferencing is the wave of the future. The use of these user-friendly systems will save millions in lost productivity and travel cost throughout the nation. The ease of operation and conference scheduling will play a key role on the extent industry uses this new technology. The INEL/EG&G has developed a prototype scheduling system for both commercial and federal government use.

Video conferencing made easy

NASA Astrophysics Data System (ADS)

Larsen, D. G.; Schwieder, P. R.

Network video conferencing is advancing rapidly throughout the nation, and the Idaho National Engineering Laboratory (INEL), a Department of Energy (DOE) facility, is at the forefront of the development. Engineers at INEL/EG&G designed and installed a very unique DOE video conferencing system, offering many outstanding features, that include true multipoint conferencing, user-friendly design and operation with no full-time operators required, and the potential for cost effective expansion of the system. One area where INEL/EG&G engineers made a significant contribution to video conferencing was in the development of effective, user-friendly, end station driven scheduling software. A PC at each user site is used to schedule conferences via a windows package. This software interface provides information to the users concerning conference availability, scheduling, initiation, and termination. The menus are 'mouse' controlled. Once a conference is scheduled, a workstation at the hub monitors the network to initiate all scheduled conferences. No active operator participation is required once a user schedules a conference through the local PC; the workstation automatically initiates and terminates the conference as scheduled. As each conference is scheduled, hard copy notification is also printed at each participating site. Video conferencing is the wave of the future. The use of these user-friendly systems will save millions in lost productivity and travel costs throughout the nation. The ease of operation and conference scheduling will play a key role on the extent industry uses this new technology. The INEL/EG&G has developed a prototype scheduling system for both commercial and federal government use.

Development of a high efficiency integration system and promoter library for rapid modification of Pseudomonas putida KT2440

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elmore, Joshua R.; Furches, Anna; Wolff, Gara N.

Pseudomonas putida strains are highly robust bacteria known for their ability to efficiently utilize a variety of carbon sources, including aliphatic and aromatic hydrocarbons. Recently, P. putida has been engineered to valorize the lignin stream of a lignocellulosic biomass pretreatment process. Nonetheless, when compared to platform organisms such as Escherichia coli, the toolkit for engineering P. putida is underdeveloped. Heterologous gene expression in particular is problematic. Plasmid instability and copy number variance provide challenges for replicative plasmids, while use of homologous recombination for insertion of DNA into the chromosome is slow and laborious. Furthermore, heterologous expression efforts to date typicallymore » rely on overexpression of exogenous pathways using a handful of poorly characterized promoters. In order to improve the P. putida toolkit, we developed a rapid genome integration system using the site-specific recombinase from bacteriophage Bxb1 to enable rapid, high efficiency integration of DNA into the P. putida chromosome. We also developed a library of synthetic promoters with various UP elements, -35 sequences, and -10 sequences, as well as different ribosomal binding sites. We tested these promoters using a fluorescent reporter gene, mNeonGreen, to characterize the strength of each promoter, and identified UP-element-promoter-ribosomal binding sites combinations capable of driving a ~150-fold range of protein expression levels. One additional integrating vector was developed that confers more robust kanamycin resistance when integrated at single copy into the chromosome. This genome integration and reporter systems are extensible for testing other genetic parts, such as examining terminator strength, and will allow rapid integration of heterologous pathways for metabolic engineering.« less

Sample Return Primer and Handbook

NASA Technical Reports Server (NTRS)

Barrow, Kirk; Cheuvront, Allan; Faris, Grant; Hirst, Edward; Mainland, Nora; McGee, Michael; Szalai, Christine; Vellinga, Joseph; Wahl, Thomas; Williams, Kenneth;

Resilient Control and Intrusion Detection for SCADA Systems

DTIC Science & Technology

2014-05-01

Control. McGraw-Hill, 1996. [89] L. Greenemeier. Robots arrive at fukushima nuclear site with unclear mission. Scientific American, 2011. [90] M. Grimes...security engineering task. SCADA systems are hard real-time systems [251] because the completion of an operation after its deadline is considered useless and...that the attacker, after gaining unauthenticated access, could change the operator display values so that when an alarm actually goes off, the human

Setup and Operation of the TeleEngineering Communications Equipment - Fixed Site (TCE-F), Version II

DTIC Science & Technology

2004-10-01

Overview ......................................................................... 3 A D T R A N IM U X ...the interconnections of the components. ADTRAN The ADTRAN provided with the continental United States systems is typi- cally a 2 x 64 version and...34FDX." After the FDX message appears and the system remains in the FDX mode, the Online button will flash , indicating the system is ready for a

Pool boiler heat transport system for a 25 kWe advanced Stirling conversion system

NASA Astrophysics Data System (ADS)

Anderson, W. G.; Rosenfeld, J. H.; Saaski, E. L.; Noble, J.; Tower, L.

Experiments to determine alkali metal/enhanced surface combinations that have stable boiling at the temperatures and heat fluxes that occur in the Stirling engine are reported. Two enhanced surfaces and two alkali metal working fluids were evaluated. The enhanced surfaces were an EDM hole covered surface and a sintered-powder-metal porous layer surface. The working fluids tested were potassium and eutectic sodium-potasium alloy (NaK), both with and without undissolved noncondensible gas. Noncondensible gas (He and Xe) was added to the system to provide gas in the nucleation sites, preventing quenching of the sites. The experiments demonstrated the potential of an alkali metal pool boiler heat transport system for use in a solar-powered Stirling engine. The most favorable fluid/surface combination tested was NaK boiling on a -100 +140 mesh 304L stainless steel sintered porous layer with no undissolved noncondensible gas. This combination provided stable, high-performance boiling at the operating temperature of 700 C. Heat fluxes into the system ranged from 10 to 50 W/sq cm. The transition from free convection to nucleate boiling occurred at temperatures near 540 C. Based on these experiments, a pool boiler was designed for a full-scale 25-kWe Stirling system.

Pool boiler heat transport system for a 25 kWe advanced Stirling conversion system

NASA Technical Reports Server (NTRS)

Anderson, W. G.; Rosenfeld, J. H.; Saaski, E. L.; Noble, J.; Tower, L.

1990-01-01

Experiments to determine alkali metal/enhanced surface combinations that have stable boiling at the temperatures and heat fluxes that occur in the Stirling engine are reported. Two enhanced surfaces and two alkali metal working fluids were evaluated. The enhanced surfaces were an EDM hole covered surface and a sintered-powder-metal porous layer surface. The working fluids tested were potassium and eutectic sodium-potasium alloy (NaK), both with and without undissolved noncondensible gas. Noncondensible gas (He and Xe) was added to the system to provide gas in the nucleation sites, preventing quenching of the sites. The experiments demonstrated the potential of an alkali metal pool boiler heat transport system for use in a solar-powered Stirling engine. The most favorable fluid/surface combination tested was NaK boiling on a -100 +140 mesh 304L stainless steel sintered porous layer with no undissolved noncondensible gas. This combination provided stable, high-performance boiling at the operating temperature of 700 C. Heat fluxes into the system ranged from 10 to 50 W/sq cm. The transition from free convection to nucleate boiling occurred at temperatures near 540 C. Based on these experiments, a pool boiler was designed for a full-scale 25-kWe Stirling system.

Draft Supplement to Final Environmental Statement on Continental United States (CONUS) Over-the-Horizon Backscatter (OTH-B) Radar System, Penobscot, Washington, Somerset Counties, Maine.

DTIC Science & Technology

1981-08-01

by psychological tests and EEG recordings. No statistically significant differences between the two groups were found. In our opinion, the lack of...phenomena. A jet engine test facility is located immediately south of the site. Engines are tested at the facility approximately 20 times a year. The...duration of each test is approximately 68 minutes. Noise monitoring data for operation of this facility are not available; however, it is clear that

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch.

PubMed

Oakes, Benjamin L; Nadler, Dana C; Flamholz, Avi; Fellmann, Christof; Staahl, Brett T; Doudna, Jennifer A; Savage, David F

2016-06-01

The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated protein Cas9 from Streptococcus pyogenes is an RNA-guided DNA endonuclease with widespread utility for genome modification. However, the structural constraints limiting the engineering of Cas9 have not been determined. Here we experimentally profile Cas9 using randomized insertional mutagenesis and delineate hotspots in the structure capable of tolerating insertions of a PDZ domain without disruption of the enzyme's binding and cleavage functions. Orthogonal domains or combinations of domains can be inserted into the identified sites with minimal functional consequence. To illustrate the utility of the identified sites, we construct an allosterically regulated Cas9 by insertion of the estrogen receptor-α ligand-binding domain. This protein showed robust, ligand-dependent activation in prokaryotic and eukaryotic cells, establishing a versatile one-component system for inducible and reversible Cas9 activation. Thus, domain insertion profiling facilitates the rapid generation of new Cas9 functionalities and provides useful data for future engineering of Cas9.

Subscale Validation of the Subsurface Active Filtration of Exhaust (SAFE) Approach to NTP Ground Testing

NASA Technical Reports Server (NTRS)

Marshall, William M.; Borowski, Stanley K.; Bulman, Mel; Joyner, Russell; Martin, Charles R.

2015-01-01

Brief History of NTP: Project Rover Began in 1950s by Los Alamos Scientific Labs (now Los Alamos National Labs) and ran until 1970s Tested a series of nuclear reactor engines of varying size at Nevada Test Site (now Nevada National Security Site) Ranged in scale from 111 kN (25 klbf) to 1.1 MN (250 klbf) Included Nuclear Furnace-1 tests Demonstrated the viability and capability of a nuclear rocket engine test program One of Kennedys 4 goals during famous moon speech to Congress Nuclear Engines for Rocket Vehicle Applications (NERVA) Atomic Energy Commission and NASA joint venture started in 1964 Parallel effort to Project Rover was focused on technology demonstration Tested XE engine, a 245-kN (55-klbf) engine to demonstrate startup shutdown sequencing. Hot-hydrogen stream is passed directly through fuel elements potential for radioactive material to be eroded into gaseous fuel flow as identified in previous programs NERVA and Project Rover (1950s-70s) were able to test in open atmosphere similar to conventional rocket engine test stands today Nuclear Furance-1 tests employed a full scrubber system Increased government and environmental regulations prohibit the modern testing in open atmosphere. Since the 1960s, there has been an increasing cessation on open air testing of nuclear material Political and national security concerns further compound the regulatory environment

The Use Of Double Pulsed Holography For On-Site Vibration Analysis

NASA Astrophysics Data System (ADS)

Tyrer, John R.

1985-06-01

A description is given of a laser system used to produce interferograms of a large centrifugal compressor, powered by an industrial gas turbine engine with a dominant system response at 168Hz. The results demonstrate a travelling wave generated within the feed pipe to the compressor. Finally the description of a potential real time double pulse systeu is presented.

Study of Lyndon B. Johnson Space Center utility systems

NASA Technical Reports Server (NTRS)

Redding, T. E.; Huber, W. C.

1977-01-01

The results of an engineering study of potential energy saving utility system modifications for the NASA Lyndon B. Johnson Space Center are presented. The objective of the study was to define and analyze utility options that would provide facility energy savings in addition to the approximately 25 percent already achieved through an energy loads reduction program. A systems engineering approach was used to determine total system energy and cost savings resulting from each of the ten major options investigated. The results reported include detailed cost analyses and cost comparisons of various options. Cost are projected to the year 2000. Also included are a brief description of a mathematical model used for the analysis and the rationale used for a site survey to select buildings suitable for analysis.

Direct application of geothermal energy at the L'eggs Product Plant, Las Cruces, New Mexico. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-02-01

The study program to determine the feasibility of interfacing a potential geothermal resource of Dona Ana County, New Mexico L'eggs Product industrial process is discussed in this final report. Five separate sites were evaluated initially as to geothermal potential and technical feasibility. Preliminary analysis revealed that three sites were considered normal, but that two sites (about three miles from the L'eggs Plant) had very high shallow subsurface temperature gradients (up to 14.85/sup 0/F/100 ft). An initial engineering analysis showed that to meet the L'eggs plant temperature and energy requirements a geothermal fluid temperature of about 250/sup 0/F and 200 gpmmore » flow rate would be necessary. A brief economic comparison indicated that the L'eggs plant site and a geothermal site approximately four miles from the plant did merit further investigation. Detailed engineering and economic design and analysis of these two sites (including the drilling of an 1873 feet deep temperature gradient test hole at the L'eggs Plant) showed that development of the four mile distant site was technically feasible and was the more economic option. It was determined that a single-stage flash system interface design would be most appropriate for the L'eggs Plant. Approximately 39 billion Btu/yr of fossil fuel could be replaced with geothermal energy at the L'eggs facility for a total installed system cost of slightly over $2 million. The projected economic payback period was calculated to be 9.2 years before taxes. This payback was not considered acceptable by L'eggs Products, Inc., to merit additional design or construction work at this time.« less

10 CFR 963.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the sealing of shafts and ramps, except those openings that may be designed for ventilation or... repository, as defined by this section, at the Yucca Mountain site. Design means a description of the... includes the engineered barrier system. Design bases means that information that identifies the specific...

10 CFR 963.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the sealing of shafts and ramps, except those openings that may be designed for ventilation or... repository, as defined by this section, at the Yucca Mountain site. Design means a description of the... includes the engineered barrier system. Design bases means that information that identifies the specific...

Dynamic Interactions for Network Visualization and Simulation

DTIC Science & Technology

2009-03-01

projects.htm, Site accessed January 5, 2009. 12. John S. Weir, Major, USAF, Mediated User-Simulator Interactive Command with Visualization ( MUSIC -V). Master’s...Computing Sciences in Colleges, December 2005). 14. Enrique Campos -Nanez, “nscript user manual,” Department of System Engineer- ing University of

Procedures for Computing Site Seismicity

DTIC Science & Technology

1994-02-01

Fourth World Conference on Earthquake Engineering, Santiago, Chile , 1969. Schnabel, P.B., J. Lysmer, and H.B. Seed (1972). SHAKE, a computer program for...This fault system is composed of the Elsinore and Whittier fault zones, Agua Caliente fault, and Earthquake Valley fault. Five recent earthquakes of

HYNOL PROCESS ENGINEERING: PROCESS CONFIGURATION, SITE PLAN, AND EQUIPMENT DESIGN

EPA Science Inventory

The report describes the design of the hydropyrolysis reactor system of the Hynol process. (NOTE: A bench scale methanol production facility is being constructed to demonstrate the technical feasibility of producing methanol from biomass using the Hynol process. The plant is bein...

10 CFR 963.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the sealing of shafts and ramps, except those openings that may be designed for ventilation or... repository, as defined by this section, at the Yucca Mountain site. Design means a description of the... includes the engineered barrier system. Design bases means that information that identifies the specific...

10 CFR 963.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the sealing of shafts and ramps, except those openings that may be designed for ventilation or... repository, as defined by this section, at the Yucca Mountain site. Design means a description of the... includes the engineered barrier system. Design bases means that information that identifies the specific...

10 CFR 963.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the sealing of shafts and ramps, except those openings that may be designed for ventilation or... repository, as defined by this section, at the Yucca Mountain site. Design means a description of the... includes the engineered barrier system. Design bases means that information that identifies the specific...

JPL Contamination Control Engineering

NASA Technical Reports Server (NTRS)

Blakkolb, Brian

2013-01-01

JPL has extensive expertise fielding contamination sensitive missions-in house and with our NASA/industry/academic partners.t Development and implementation of performance-driven cleanliness requirements for a wide range missions and payloads - UV-Vis-IR: GALEX, Dawn, Juno, WFPC-II, AIRS, TES, et al - Propulsion, thermal control, robotic sample acquisition systems. Contamination control engineering across the mission life cycle: - System and payload requirements derivation, analysis, and contamination control implementation plans - Hardware Design, Risk trades, Requirements V-V - Assembly, Integration & Test planning and implementation - Launch site operations and launch vehicle/payload integration - Flight ops center dot Personnel on staff have expertise with space materials development and flight experiments. JPL has capabilities and expertise to successfully address contamination issues presented by space and habitable environments. JPL has extensive experience fielding and managing contamination sensitive missions. Excellent working relationship with the aerospace contamination control engineering community/.

Preparing and probing many-body correlated systems in a Quantum Gas Microscope by engineering arbitrary landscape potentials

NASA Astrophysics Data System (ADS)

Rispoli, Matthew; Lukin, Alexander; Ma, Ruichao; Preiss, Philipp; Tai, M. Eric; Islam, Rajibul; Greiner, Markus

2015-05-01

Ultracold atoms in optical lattices provide a versatile tool box for observing the emergence of strongly correlated physics in quantum systems. Dynamic control of optical potentials on the single-site level allows us to prepare and probe many-body quantum states through local Hamiltonian engineering. We achieve these high precision levels of optical control through spatial light modulation with a DMD (digital micro-mirror device). This allows for both arbitrary beam shaping and aberration compensation in our imaging system to produce high fidelity optical potentials. We use these techniques to control state initialization, Hamiltonian dynamics, and measurement in experiments investigating low-dimensional many-body physics - from one-dimensional correlated quantum walks to characterizing entanglement.

Indexing method for assessment of pollution potential of leachate from non-engineered landfill sites and its effect on ground water quality.

PubMed

Rana, Rishi; Ganguly, Rajiv; Gupta, Ashok Kumar

2017-12-26

Dumping of solid waste in a non-engineered landfill site often leads to contamination of ground water due to leachate percolation into ground water. The present paper assesses the pollution potential of leachate generated from three non-engineered landfill sites located in the Tricity region (one each in cities of Chandigarh, Mohali and Panchkula) of Northern India and its possible effects of contamination of groundwater. Analysis of physico-chemical properties of leachate from all the three landfill sites and the surrounding groundwater samples from five different downwind distances from each of the landfill sites were collected and tested to determine the leachate pollution index (LPI) and the water quality index (WQI). The Leachate Pollution Index values of 26.1, 27 and 27.8 respectively for landfill sites of Chandigarh (CHD), Mohali (MOH) and Panchkula (PKL) cities showed that the leachate generated are contaminated. The average pH values of the leachate samples over the sampling period (9.2 for CHD, 8.97 for MOH and 8.9 for PKL) show an alkaline nature indicating that all the three landfill sites could be classified as mature to old stage. The WQI calculated over the different downwind distances from the contamination sites showed that the quality of the groundwater improved with an increase in the downwind distance. Principal component analysis (PCA) carried out established major components mainly from natural and anthropogenic sources with cumulative variance of 88% for Chandigarh, 87.1% for Mohali and 87.8% for Panchkula. Hierarchical cluster analysis (HCA) identifies three distinct cluster types for the groundwater samples. These clusters corresponds to a relatively low pollution, moderate pollution and high pollution regions. It is suggested that all the three non-engineered landfill sites be converted to engineered landfill sites to prevent groundwater contamination and also new sites be considered for construction of these engineered landfill sites as the present dumpsites are nearing the end of their lifespan capacity.

Portable bioreactor for perfusion and electrical stimulation of engineered cardiac tissue.

PubMed

Tandon, Nina; Taubman, Alanna; Cimetta, Elisa; Saccenti, Laetitia; Vunjak-Novakovic, Gordana

2013-01-01

Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Although bioreactors have facilitated the engineering of cardiac patches of clinically relevant size in vitro, a major drawback remains the transportation of the engineered tissues from a production facility to a medical operation facility while maintaining tissue viability and preventing contamination. Furthermore, after implantation, most of the cells are endangered by hypoxic conditions that exist before vascular flow is established. We developed a portable device that provides the perfusion and electrical stimulation necessary to engineer cardiac tissue in vitro, and to transport it to the site where it will be implantated. The micropump-powered perfusion apparatus may additionally function as an extracorporeal active pumping system providing nutrients and oxygen supply to the graft post-implantation. Such a system, through perfusion of oxygenated media and bioactive molecules (e.g. growth factors), could transiently support the tissue construct until it connects to the host vasculature and heart muscle, after which it could be taken away or let biodegrade.

Entry Atmospheric Flight Control Authority Impacts on GN and C and Trajectory Performance for Orion Exploration Flight Test 1

NASA Technical Reports Server (NTRS)

McNamara, Luke W.

2012-01-01

One of the key design objectives of NASA's Orion Exploration Flight Test 1 (EFT-1) is to execute a guided entry trajectory demonstrating GN&C capability. The focus of this paper is the ight control authority of the vehicle throughout the atmospheric entry ight to the target landing site and its impacts on GN&C, parachute deployment, and integrated performance. The vehicle's attitude control authority is obtained from thrusting 12 Re- action Control System (RCS) engines, with four engines to control yaw, four engines to control pitch, and four engines to control roll. The static and dynamic stability derivatives of the vehicle are determined to assess the inherent aerodynamic stability. The aerodynamic moments at various locations in the entry trajectory are calculated and compared to the available torque provided by the RCS system. Interaction between the vehicle's RCS engine plumes and the aerodynamic conditions are considered to assess thruster effectiveness. This document presents an assessment of Orion's ight control authority and its effectiveness in controlling the vehicle during critical events in the atmospheric entry trajectory.

32 CFR 203.10 - Eligible activities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... reports include, but are not limited to: (i) Installation restoration program site studies, engineering documents, such as site inspections, remedial investigations, feasibility studies, engineering evaluation...

Phase 1 Development Report for the SESSA Toolkit.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knowlton, Robert G.; Melton, Brad J; Anderson, Robert J.

The Site Exploitation System for Situational Awareness ( SESSA ) tool kit , developed by Sandia National Laboratories (SNL) , is a comprehensive de cision support system for crime scene data acquisition and Sensitive Site Exploitation (SSE). SESSA is an outgrowth of another SNL developed decision support system , the Building R estoration Operations Optimization Model (BROOM), a hardware/software solution for data acquisition, data management, and data analysis. SESSA was designed to meet forensic crime scene needs as defined by the DoD's Military Criminal Investigation Organiza tion (MCIO) . SESSA is a very comprehensive toolki t with a considerable amountmore » of database information managed through a Microsoft SQL (Structured Query Language) database engine, a Geographical Information System (GIS) engine that provides comprehensive m apping capabilities, as well as a an intuitive Graphical User Interface (GUI) . An electronic sketch pad module is included. The system also has the ability to efficiently generate necessary forms for forensic crime scene investigations (e.g., evidence submittal, laboratory requests, and scene notes). SESSA allows the user to capture photos on site, and can read and generate ba rcode labels that limit transcription errors. SESSA runs on PC computers running Windows 7, but is optimized for touch - screen tablet computers running Windows for ease of use at crime scenes and on SSE deployments. A prototype system for 3 - dimensional (3 D) mapping and measur e ments was also developed to complement the SESSA software. The mapping system employs a visual/ depth sensor that captures data to create 3D visualizations of an interior space and to make distance measurements with centimeter - level a ccuracy. Output of this 3D Model Builder module provides a virtual 3D %22walk - through%22 of a crime scene. The 3D mapping system is much less expensive and easier to use than competitive systems. This document covers the basic installation and operation of th e SESSA tool kit in order to give the user enough information to start using the tool kit . SESSA is currently a prototype system and this documentation covers the initial release of the tool kit . Funding for SESSA was provided by the Department of Defense (D oD), Assistant Secretary of Defense for Research and Engineering (ASD(R&E)) Rapid Fielding (RF) organization. The project was managed by the Defense Forensic Science Center (DFSC) , formerly known as the U.S. Army Criminal Investigation Laboratory (USACIL) . ACKNOWLEDGEMENTS The authors wish to acknowledge the funding support for the development of the Site Exploitation System for Situational Awareness (SESSA) toolkit from the Department of Defense (DoD), Assistant Secretary of Defense for Research and Engineering (ASD(R&E)) Rapid Fielding (RF) organization. The project was managed by the Defense Forensic Science Center (DFSC) , formerly known as the U.S. Army Criminal Investigation Laboratory (USACIL). Special thanks to Mr. Garold Warner, of DFSC, who served as the Project Manager. Individuals that worked on the design, functional attributes, algorithm development, system arc hitecture, and software programming include: Robert Knowlton, Brad Melton, Robert Anderson, and Wendy Amai.« less

The use of remote sensing in solving Florida's geological and coastal engineering problems

NASA Technical Reports Server (NTRS)

Brooks, H. K.; Ruth, B. E.; Wang, Y. H.; Ferguson, R. L.

1977-01-01

LANDSAT imagery and NASA high altitude color infrared (CIR) photography were used to select suitable sites for sanitary landfill in Volusia County, Florida and to develop techniques for preventing sand deposits in the Clearwater inlet. Activities described include the acquisition of imagery, its analysis by the IMAGE 100 system, conventional photointerpretation, evaluation of existing data sources (vegetation, soil, and ground water maps), site investigations for ground truth, and preparation of displays for reports.

Remote-handled/special case TRU waste characterization summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Detamore, J.A.

1984-02-27

Remote-handled wastes are stored at Los Alamos, Hanford, Oak Ridge, and the Idaho National Engineering Laboratory. The following will be a site by site discussion of RH waste handling, placement, and container data. This will be followed by a series of data tables that were compiled in the TRU Waste Systems Office. These tables are a compendium of data that is the most up to date and accurate data available today. 2 figures, 10 tables.

Crew Health Care System (CHeCS) Design Research, Documentations, and Evaluations

NASA Technical Reports Server (NTRS)

CLement, Bethany M.

2011-01-01

The Crew Health Care System (CHeCS) is a group within the Space Life Science Directorate (SLSD) that focuses on the overall health of astronauts by reinforcing the three divisions - the Environmental Maintenance System (EMS), the Countermeasures System (CMS), and the Health Maintenance System (HMS). This internship provided opportunity to gain knowledge, experience, and skills in CHeCS engineering and operations tasks. Various and differing tasks allowed for occasions to work independently, network to get things done, and show leadership abilities. Specific exercises included reviewing hardware certification, operations, and documentation within the ongoing Med Kit Redesign (MKR) project, and learning, writing, and working various common pieces of paperwork used in the engineering and design process. Another project focused on the distribution of various pieces of hardware to off-site research facilities with an interest in space flight health care. The main focus of this internship, though, was on a broad and encompassing understanding of the engineering process as time was spent looking at each individual step in a variety of settings and tasks.

The Launch Processing System for Space Shuttle.

NASA Technical Reports Server (NTRS)

Springer, D. A.

1973-01-01

In order to reduce costs and accelerate vehicle turnaround, a single automated system will be developed to support shuttle launch site operations, replacing a multiplicity of systems used in previous programs. The Launch Processing System will provide real-time control, data analysis, and information display for the checkout, servicing, launch, landing, and refurbishment of the launch vehicles, payloads, and all ground support systems. It will also provide real-time and historical data retrieval for management and sustaining engineering (test records and procedures, logistics, configuration control, scheduling, etc.).

76 FR 13666 - Pitney Bowes, Inc., Mailing Solutions Management, Global Engineering Group, Including On-Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

...., Mailing Solutions Management, Global Engineering Group, Including On-Site Leased Workers From Guidant... workers and former workers of Pitney Bowes, Inc., Mailing Solutions Management Division, Engineering... reviewed the certification to clarify the subject worker group's identity. Additional information revealed...

Experimental Results of Site Calibration and Sensitivity Measurements in OTR for UWB Systems

NASA Astrophysics Data System (ADS)

Viswanadham, Chandana; Rao, P. Mallikrajuna

2017-06-01

System calibration and parameter accuracy measurement of electronic support measures (ESM) systems is a major activity, carried out by electronic warfare (EW) engineers. These activities are very critical and needs good understanding in the field of microwaves, antennas, wave propagation, digital and communication domains. EW systems are broad band, built with state-of-the art electronic hardware, installed on different varieties of military platforms to guard country's security from time to time. EW systems operate in wide frequency ranges, typically in the order of thousands of MHz, hence these are ultra wide band (UWB) systems. Few calibration activities are carried within the system and in the test sites, to meet the accuracies of final specifications. After calibration, parameters are measured for their accuracies either in feed mode by injecting the RF signals into the front end or in radiation mode by transmitting the RF signals on to system antenna. To carry out these activities in radiation mode, a calibrated open test range (OTR) is necessary in the frequency band of interest. Thus site calibration of OTR is necessary to be carried out before taking up system calibration and parameter measurements. This paper presents the experimental results of OTR site calibration and sensitivity measurements of UWB systems in radiation mode.

Offshore Wind Energy Systems Engineering Curriculum Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGowan, Jon G.; Manwell, James F.; Lackner, Matthew A.

2012-12-31

Utility-scale electricity produced from offshore wind farms has the potential to contribute significantly to the energy production of the United States. In order for the U.S. to rapidly develop these abundant resources, knowledgeable scientists and engineers with sound understanding of offshore wind energy systems are critical. This report summarizes the development of an upper-level engineering course in "Offshore Wind Energy Systems Engineering." This course is designed to provide students with a comprehensive knowledge of both the technical challenges of offshore wind energy and the practical regulatory, permitting, and planning aspects of developing offshore wind farms in the U.S. This coursemore » was offered on a pilot basis in 2011 at the University of Massachusetts and the National Renewable Energy Laboratory (NREL), TU Delft, and GL Garrad Hassan have reviewed its content. As summarized in this report, the course consists of 17 separate topic areas emphasizing appropriate engineering fundamentals as well as development, planning, and regulatory issues. In addition to the course summary, the report gives the details of a public Internet site where references and related course material can be obtained. This course will fill a pressing need for the education and training of the U.S. workforce in this critically important area. Fundamentally, this course will be unique due to two attributes: an emphasis on the engineering and technical aspects of offshore wind energy systems, and a focus on offshore wind energy issues specific to the United States.« less

75 FR 60495 - Eighteenth Plenary Meeting: RTCA Special Committee 203: Unmanned Aircraft Systems

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

..., 20036; telephone (202) 833-9339; fax (202) 833-9434; Web site http://www.rtca.org . SUPPLEMENTARY... Product Team Breakout Session. RTCA Workspace Web Tool. Closing Plenary Session. Plenary Adjourns until... Engineering Workgroup. Control and Communications Workgroup. Sense and Avoid Workgroup. Wednesday, October...

Non-Local Propagation of Correlations in Quantum Systems with Long-Range Interactions

DTIC Science & Technology

2014-07-10

interferencepathways13.Thisprocessdiffers substantially from local quenches21, where a single site emits quasiparticles thatmay travel ballistically3,13...Preprint at http://arxiv.org/abs/1401.6174 (2014). 21. Jurcevic, P. et al. Quasiparticle engineering and entanglement propagation in a quantummany-body

Bacteriophage recombination systems and biotechnical applications.

PubMed

Nafissi, Nafiseh; Slavcev, Roderick

2014-04-01

Bacteriophage recombination systems have been widely used in biotechnology for modifying prokaryotic species, for creating transgenic animals and plants, and more recently, for human cell gene manipulation. In contrast to homologous recombination, which benefits from the endogenous recombination machinery of the cell, site-specific recombination requires an exogenous source of recombinase in mammalian cells. The mechanism of bacteriophage evolution and their coexistence with bacterial cells has become a point of interest ever since bacterial viruses' life cycles were first explored. Phage recombinases have already been exploited as valuable genetic tools and new phage enzymes, and their potential application to genetic engineering and genome manipulation, vectorology, and generation of new transgene delivery vectors, and cell therapy are attractive areas of research that continue to be investigated. The significance and role of phage recombination systems in biotechnology is reviewed in this paper, with specific focus on homologous and site-specific recombination conferred by the coli phages, λ, and N15, the integrase from the Streptomyces phage, ΦC31, the recombination system of phage P1, and the recently characterized recombination functions of Yersinia phage, PY54. Key steps of the molecular mechanisms involving phage recombination functions and their application to molecular engineering, our novel exploitations of the PY54-derived recombination system, and its application to the development of new DNA vectors are discussed.

47 CFR 5.55 - Filing of applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the Office of Engineering and Technology Web site https://gullfoss2.fcc.gov/prod/oet/cf/els/index.cfm... Office of Engineering and Technology Web site https://gullfoss2.fcc.gov/prod/oet/cf/els/index.cfm... instead be submitted to the Commission's Office of Engineering and Technology, Washington, DC 20554...

47 CFR 5.55 - Filing of applications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the Office of Engineering and Technology Web site https://gullfoss2.fcc.gov/prod/oet/cf/els/index.cfm... Office of Engineering and Technology Web site https://gullfoss2.fcc.gov/prod/oet/cf/els/index.cfm... instead be submitted to the Commission's Office of Engineering and Technology, Washington, DC 20554...

47 CFR 5.55 - Filing of applications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... the Office of Engineering and Technology Web site https://gullfoss2.fcc.gov/prod/oet/cf/els/index.cfm... Office of Engineering and Technology Web site https://gullfoss2.fcc.gov/prod/oet/cf/els/index.cfm... instead be submitted to the Commission's Office of Engineering and Technology, Washington, DC 20554...

Geotechnical engineering for ocean waste disposal. An introduction

USGS Publications Warehouse

Lee, Homa J.; Demars, Kenneth R.; Chaney, Ronald C.; ,

1990-01-01

As members of multidisciplinary teams, geotechnical engineers apply quantitative knowledge about the behavior of earth materials toward designing systems for disposing of wastes in the oceans and monitoring waste disposal sites. In dredge material disposal, geotechnical engineers assist in selecting disposal equipment, predict stable characteristics of dredge mounds, design mound caps, and predict erodibility of the material. In canister disposal, geotechnical engineers assist in specifying canister configurations, predict penetration depths into the seafloor, and predict and monitor canister performance following emplacement. With sewage outfalls, geotechnical engineers design foundation and anchor elements, estimate scour potential around the outfalls, and determine the stability of deposits made up of discharged material. With landfills, geotechnical engineers evaluate the stability and erodibility of margins and estimate settlement and cracking of the landfill mass. Geotechnical engineers also consider the influence that pollutants have on the engineering behavior of marine sediment and the extent to which changes in behavior affect the performance of structures founded on the sediment. In each of these roles, careful application of geotechnical engineering principles can contribute toward more efficient and environmentally safe waste disposal operations.

Modification site localization scoring integrated into a search engine.

PubMed

Baker, Peter R; Trinidad, Jonathan C; Chalkley, Robert J

2011-07-01

Large proteomic data sets identifying hundreds or thousands of modified peptides are becoming increasingly common in the literature. Several methods for assessing the reliability of peptide identifications both at the individual peptide or data set level have become established. However, tools for measuring the confidence of modification site assignments are sparse and are not often employed. A few tools for estimating phosphorylation site assignment reliabilities have been developed, but these are not integral to a search engine, so require a particular search engine output for a second step of processing. They may also require use of a particular fragmentation method and are mostly only applicable for phosphorylation analysis, rather than post-translational modifications analysis in general. In this study, we present the performance of site assignment scoring that is directly integrated into the search engine Protein Prospector, which allows site assignment reliability to be automatically reported for all modifications present in an identified peptide. It clearly indicates when a site assignment is ambiguous (and if so, between which residues), and reports an assignment score that can be translated into a reliability measure for individual site assignments.

Collaborative engineering and design management for the Hobby-Eberly Telescope tracker upgrade

NASA Astrophysics Data System (ADS)

Mollison, Nicholas T.; Hayes, Richard J.; Good, John M.; Booth, John A.; Savage, Richard D.; Jackson, John R.; Rafal, Marc D.; Beno, Joseph H.

2010-07-01

The engineering and design of systems as complex as the Hobby-Eberly Telescope's* new tracker require that multiple tasks be executed in parallel and overlapping efforts. When the design of individual subsystems is distributed among multiple organizations, teams, and individuals, challenges can arise with respect to managing design productivity and coordinating successful collaborative exchanges. This paper focuses on design management issues and current practices for the tracker design portion of the Hobby-Eberly Telescope Wide Field Upgrade project. The scope of the tracker upgrade requires engineering contributions and input from numerous fields including optics, instrumentation, electromechanics, software controls engineering, and site-operations. Successful system-level integration of tracker subsystems and interfaces is critical to the telescope's ultimate performance in astronomical observation. Software and process controls for design information and workflow management have been implemented to assist the collaborative transfer of tracker design data. The tracker system architecture and selection of subsystem interfaces has also proven to be a determining factor in design task formulation and team communication needs. Interface controls and requirements change controls will be discussed, and critical team interactions are recounted (a group-participation Failure Modes and Effects Analysis [FMEA] is one of special interest). This paper will be of interest to engineers, designers, and managers engaging in multi-disciplinary and parallel engineering projects that require coordination among multiple individuals, teams, and organizations.

Methane Emissions from Leak and Loss Audits of Natural Gas Compressor Stations and Storage Facilities.

PubMed

Johnson, Derek R; Covington, April N; Clark, Nigel N

2015-07-07

As part of the Environmental Defense Fund's Barnett Coordinated Campaign, researchers completed leak and loss audits for methane emissions at three natural gas compressor stations and two natural gas storage facilities. Researchers employed microdilution high-volume sampling systems in conjunction with in situ methane analyzers, bag samples, and Fourier transform infrared analyzers for emissions rate quantification. All sites had a combined total methane emissions rate of 94.2 kg/h, yet only 12% of the emissions total resulted from leaks. Methane slip from exhausts represented 44% of the total emissions. Remaining methane emissions were attributed to losses from pneumatic actuators and controls, engine crankcases, compressor packing vents, wet seal vents, and slop tanks. Measured values were compared with those reported in literature. Exhaust methane emissions were lower than emissions factor estimates for engine exhausts, but when combined with crankcase emissions, measured values were 11.4% lower than predicted by AP-42 as applicable to emissions factors for four-stroke, lean-burn engines. Average measured wet seal emissions were 3.5 times higher than GRI values but 14 times lower than those reported by Allen et al. Reciprocating compressor packing vent emissions were 39 times higher than values reported by GRI, but about half of values reported by Allen et al. Though the data set was small, researchers have suggested a method to estimate site-wide emissions factors for those powered by four-stroke, lean-burn engines based on fuel consumption and site throughput.

Active Reliability Engineering - Technical Concept and Program Plan. A Solid-State Systems Approach to Increased Reliability and Availability in Military Systems.

DTIC Science & Technology

1983-10-05

battle damage. Others are local electrical power and cooling disruptions. Again, a highly critical function is lost if its computer site is destroyed. A...formalized design of the test bed to meet the requirements of the functional description and goals of the program. AMTEC --Z3IT TASKS: 610, 710, 810

Air Quality Management Using Pollution Prevention: A Joint Service Approach

DTIC Science & Technology

1998-03-01

sites to promote polymerization. High solids coatings may be one or two component systems based on acrylic , alkyd , epoxy, polyester, or urethane...formulation to form high molecular weight polymers. Examples include acrylic , epoxy/polyester hybrid , functional epoxy, thin film epoxy, and urethane...Air Human System Center (HSC/OEBQ) Naval Facilities Engineering Service Center (NFESC) 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 9

Current and future delivery systems for engineered nucleases: ZFN, TALEN and RGEN.

PubMed

Ul Ain, Qurrat; Chung, Jee Young; Kim, Yong-Hee

2015-05-10

Gene therapy by engineered nucleases is a genetic intervention being investigated for curing the hereditary disorders by targeting selected genes with specific nucleotides for establishment, suppression, abolishment of a function or correction of mutation. Here, we review the fast developing technology of targeted genome engineering using site specific programmable nucleases zinc finger nucleases (ZFNs), transcription activator like nucleases (TALENs) and cluster regulatory interspaced short palindromic repeat/CRISPR associated proteins (CRISPR/Cas) based RNA-guided DNA endonucleases (RGENs) and their different characteristics including pros and cons of genome modifications by these nucleases. We have further discussed different types of delivery methods to induce gene editing, novel development in genetic engineering other than nucleases and future prospects. Copyright © 2014 Elsevier B.V. All rights reserved.

Flight Avionics Sequencing Telemetry (FAST) DIV Latching Display

NASA Technical Reports Server (NTRS)

Moore, Charlotte

2010-01-01

The NASA Engineering (NE) Directorate at Kennedy Space Center provides engineering services to major programs such as: Space Shuttle, Inter national Space Station, and the Launch Services Program (LSP). The Av ionics Division within NE, provides avionics and flight control syste ms engineering support to LSP. The Launch Services Program is respons ible for procuring safe and reliable services for transporting critical, one of a kind, NASA payloads into orbit. As a result, engineers mu st monitor critical flight events during countdown and launch to asse ss anomalous behavior or any unexpected occurrence. The goal of this project is to take a tailored Systems Engineering approach to design, develop, and test Iris telemetry displays. The Flight Avionics Sequen cing Telemetry Delta-IV (FAST-D4) displays will provide NASA with an improved flight event monitoring tool to evaluate launch vehicle heal th and performance during system-level ground testing and flight. Flight events monitored will include data from the Redundant Inertial Fli ght Control Assembly (RIFCA) flight computer and launch vehicle comma nd feedback data. When a flight event occurs, the flight event is ill uminated on the display. This will enable NASA Engineers to monitor c ritical flight events on the day of launch. Completion of this project requires rudimentary knowledge of launch vehicle Guidance, Navigatio n, and Control (GN&C) systems, telemetry, and console operation. Work locations for the project include the engineering office, NASA telem etry laboratory, and Delta launch sites.

CRISPR-cas System as a Genome Engineering Platform: Applications in Biomedicine and Biotechnology.

PubMed

Hashemi, Atieh

2018-01-01

Genome editing mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and its associated proteins (Cas) has recently been considered to be used as efficient, rapid and site-specific tool in the modification of endogenous genes in biomedically important cell types and whole organisms. It has become a predictable and precise method of choice for genome engineering by specifying a 20-nt targeting sequence within its guide RNA. Firstly, this review aims to describe the biology of CRISPR system. Next, the applications of CRISPR-Cas9 in various ways, such as efficient generation of a wide variety of biomedically important cellular models as well as those of animals, modifying epigenomes, conducting genome-wide screens, gene therapy, labelling specific genomic loci in living cells, metabolic engineering of yeast and bacteria and endogenous gene expression regulation by an altered version of this system were reviewed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

LHCb data quality monitoring

NASA Astrophysics Data System (ADS)

Adinolfi, M.; Archilli, F.; Baldini, W.; Baranov, A.; Derkach, D.; Panin, A.; Pearce, A.; Ustyuzhanin, A.

2017-10-01

Data quality monitoring, DQM, is crucial in a high-energy physics experiment to ensure the correct functioning of the experimental apparatus during the data taking. DQM at LHCb is carried out in two phases. The first one is performed on-site, in real time, using unprocessed data directly from the LHCb detector, while the second, also performed on-site, requires the reconstruction of the data selected by the LHCb trigger system and occurs later. For the LHC Run II data taking the LHCb collaboration has re-engineered the DQM protocols and the DQM graphical interface, moving the latter to a web-based monitoring system, called Monet, thus allowing researchers to perform the second phase off-site. In order to support the operator’s task, Monet is also equipped with an automated, fully configurable alarm system, thus allowing its use not only for DQM purposes, but also to track and assess the quality of LHCb software and simulation over time.

FY2004 SYSTEM ENGINEER PROGRAM MANAGER ANNUAL REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

JACKSON, G.J.

2004-10-29

During FY 2004, reviews of the FH System Engineer (SE) Program were conducted by the Independent Assessment (IA) Group. The results of these reviews are summarized as a part of this document. Additional reviews were performed by FH Engineering personnel. SE Engineering reviews performed include Periodic Walkdowns (typically, quarterly) by the SEs, a review of System Notebooks by the System Engineer Program Manager (SEPM), annual status report by each SE, and an annual status report by each of the Project Chief Engineers (PCEs). FY 2004 marked the completion of the first round of Vital Safety System assessments. Each of themore » VSSs on the FH VSS list has been evaluated at least once by either the FH Independent Assessment organization or was included as a part of DOE Phase II assessment. Following the completion of the K-Basins Assessment in May 2004, a review of the VSS assessment process was completed. Criteria were developed by FH, and concurred with by RL, to determine the frequency and priority of future VSS assessments. Additional actions have been taken to increase the visibility and emphasis assigned to VSSs. Completion of several Documented Safety Analyses (DSA), in combination with efforts to remove source term materials from several facilities, enabled the number of systems on the FH VSS list to be reduced from 60 at the beginning of FY 2004 to 48 by the end of FY 2004. It is expected that there will be further changes to the FH VSS list based on additional DSA revisions and continued progress towards reduction of source terms across the Hanford Site. Other new VSSs may be added to the list to reflect the relocation of materials away from the River Corridor to interim storage locations on the Central Plateau.« less

SITE EMERGING TECHNOLOGY SUMMARY. BIOSCRUBBER FOR REMOVING HAZARDOUS ORGANIC EMISSIONS FROM SOIL, WATER, AND AIR DECONTAMINATION PROCESSES

EPA Science Inventory

An advanced biofiltration system has been developed for the removal of trace organic contaminants in air. This bioscrubber uses activated carbon as a support for biogrowth. An advanced engineering design was incorporated into the bioscrubber to allow biomass removal and nutrient ...

3. NORTH ELEVATION OF THE HOT BAY, SHOWING RAILROAD TRACKS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. NORTH ELEVATION OF THE HOT BAY, SHOWING RAILROAD TRACKS LEADING TO THE MASSIVE STEEL-LINED CONCRETE ENTRANCE DOOR. PART OF THE INTRICATE HVAC SYSTEM IS WEST (RIGHT) OF THE DOOR. - Nevada Test Site, Engine Maintenance Assembly & Disassembly Facility, Area 25, Jackass Flats, Mercury, Nye County, NV

Liquid rocket booster integration study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1988-01-01

The impacts of introducing liquid rocket booster engines (LRB) into the Space Transportation System (STS)/Kennedy Space Center (KSC) launch environment are identified and evaluated. Proposed ground systems configurations are presented along with a launch site requirements summary. Prelaunch processing scenarios are described and the required facility modifications and new facility requirements are analyzed. Flight vehicle design recommendations to enhance launch processing are discussed. Processing approaches to integrate LRB with existing STS launch operations are evaluated. The key features and significance of launch site transition to a new STS configuration in parallel with ongoing launch activities are enumerated. This volume is the executive summary of the five volume series.

Liquid rocket booster integration study. Volume 5, part 1: Appendices

NASA Technical Reports Server (NTRS)

1988-01-01

The impacts of introducing liquid rocket booster engines (LRB) into the Space Transportation System (STS)/Kennedy Space Center (KSC) launch environment are identified and evaluated. Proposed ground systems configurations are presented along with a launch site requirements summary. Prelaunch processing scenarios are described and the required facility modifications and new facility requirements are analyzed. Flight vehicle design recommendations to enhance launch processing are discussed. Processing approaches to integrate LRB with existing STS launch operations are evaluated. The key features and significance of launch site transition to a new STS configuration in parallel with ongoing launch activities are enumerated. This volume is the appendices of the five volume series.

Liquid Rocket Booster Integration Study. Volume 2: Study synopsis

NASA Technical Reports Server (NTRS)

1988-01-01

The impacts of introducing liquid rocket booster engines (LRB) into the Space Transportation System (STS)/Kennedy Space Center (KSC) launch environment are identified and evaluated. Proposed ground systems configurations are presented along with a launch site requirements summary. Prelaunch processing scenarios are described and the required facility modifications and new facility requirements are analyzed. Flight vehicle design recommendations to enhance launch processing are discussed. Processing approaches to integrate LRB with existing STS launch operations are evaluated. The key features and significance of launch site transition to a new STS configuration in parallel with ongoing launch activities are enumerated. This volume is the study summary of the five volume series.

Using Natural Cementation Systems to Control Corrosion Dust on Un-surfaced Roads

DTIC Science & Technology

2010-02-01

metallurgical slags ), volcanic glass , fly ash and low-fired clays • Can use waste alkali from manufacturing operations • No Portland cement is involved Soil...solidified with alkali- activated glass slag US Army Corps of Engineers 4 Pohakuloa Training Area (PTA) as a Test Site • Serious dust problem at site...Conventional Cement? • Glass can be both the aggregate and form the cementing phase • Waste glass ( slag , fly ash) can be used • More alkaline solution is

LPT. Plot plan and site layout. Includes shield test pool/EBOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LPT. Plot plan and site layout. Includes shield test pool/EBOR facility. (TAN-645 and -646) low power test building (TAN-640 and -641), water storage tanks, guard house (TAN-642), pump house (TAN-644), driveways, well, chlorination building (TAN-643), septic system. Ralph M. Parsons 1229-12 ANP/GE-7-102. November 1956. Approved by INEEL Classification Office for public release. INEEL index code no. 038-0102-00-693-107261 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Artificial Intelligence Support for Landing Site Selection on Mars

NASA Astrophysics Data System (ADS)

Rongier, G.; Pankratius, V.

2017-12-01

Mars is a key target for planetary exploration; a better understanding of its evolution and habitability requires roving in situ. Landing site selection is becoming more challenging for scientists as new instruments generate higher data volumes. The involved engineering and scientific constraints make site selection and the anticipation of possible onsite actions into a complex optimization problem: there may be multiple acceptable solutions depending on various goals and assumptions. Solutions must also account for missing data, errors, and potential biases. To address these problems, we propose an AI-informed decision support system that allows scientists, mission designers, engineers, and committees to explore alternative site selection choices based on data. In particular, we demonstrate first results of an exploratory case study using fuzzy logic and a simulation of a rover's mobility map based on the fast marching algorithm. Our system computes favorability maps of the entire planet to facilitate landing site selection and allows a definition of different configurations for rovers, science target priorities, landing ellipses, and other constraints. For a rover similar to NASA's Mars 2020 rover, we present results in form of a site favorability map as well as four derived exploration scenarios that depend on different prioritized scientific targets, all visualizing inherent tradeoffs. Our method uses the NASA PDS Geosciences Node and the NASA/ICA Integrated Database of Planetary Features. Under common assumptions, the data products reveal Eastern Margaritifer Terra and Meridiani Planum to be the most favorable sites due to a high concentration of scientific targets and a flat, easily navigable surface. Our method also allows mission designers to investigate which constraints have the highest impact on the mission exploration potential and to change parameter ranges. Increasing the elevation limit for landing, for example, provides access to many additional, more interesting sites on the southern terrains of Mars. The speed of current rovers is another limit to exploration capabilities: our system helps quantify how speed increases can improve the number of reachable targets in the search space. We acknowledge support from NASA AISTNNX15AG84G (PI Pankratius) and NSF ACI1442997 (PI Pankratius).

[Eutrophication control in local area by physic-ecological engineering].

PubMed

Li, Qiu-Hua; Xia, Pin-Hua; Wu, Hong; Lin, Tao; Zhang, You-Chun; Li, Cun-Xiong; Chen, Li-Li; Yang, Fan

2012-07-01

An integrated physical and ecological engineering experiment for ecological remediation was performed at the Maixi River bay in Baihua Reservoir Guizhou Province, China. The results show that eutrophic parameters, such as total nitrogen, total phosphorus, chlorophyll a and chemical oxygen demand from the experimental site (enclosed water) were significantly lower than those of the reference site. The largest differences between the sites were 0.61 mg x L(-1), 0.041 mg x L(-1), 23.06 microg x L(-1), 8.4 mg x L(-1) respectively; experimental site transparency was > 1.50 m which was significantly higher than that of the reference site. The eutrophic index of the experimental site was oligo-trophic and mid-trophic, while the control site was mid-trophic state and eutrophic state. Phytoplankton abundance was 2 125.5 x 10(4) cells x L(-1) in June, 2011 at the control site,but phytoplankton abundance was lower at the experimental site with 33 x 10(4) cells x L(-1). Cyanobacteria dominated phytoplankton biomass at both sites, however the experimental site consisted of a higher proportion of diatoms and dinoflagellates. After more than one year of operation, the ecological engineering technology effectively controlled the occurrence of algae blooms, changed phytoplankton community structure, and controlled the negative impacts of eutrophication. Integrating physical and ecological engineering technology could improve water quality for reservoirs on the Guizhou plateau.

Terrain Safety Assessment in Support of the Mars Science Laboratory Mission

NASA Technical Reports Server (NTRS)

Kipp, Devin

2012-01-01

In August 2012, the Mars Science Laboratory (MSL) mission will pioneer the next generation of robotic Entry, Descent, and Landing (EDL) systems by delivering the largest and most capable rover to date to the surface of Mars. The process to select the MSL landing site took over five years and began with over 50 initial candidate sites from which four finalist sites were chosen. The four finalist sites were examined in detail to assess overall science merit, EDL safety, and rover traversability on the surface. Ultimately, the engineering assessments demonstrated a high level of safety and robustness at all four finalist sites and differences in the assessment across those sites were small enough that neither EDL safety nor rover traversability considerations could significantly discriminate among the final four sites. Thus the MSL landing site at Gale Crater was selected from among the four finalists primarily on the basis of science considerations.

75 FR 11915 - Chrysler LLC; Trenton Engine Plant, Including On-Site Leased Workers From Caravan Knight...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... workers are engaged in the production of automotive engines, a substantial portion of which are shipped to..., Michigan location of Chrysler, LLC, Trenton Engine Plant. The Department has determined that these workers... Facilities Management, LLC, working on-site at the Trenton, Michigan location of Chrysler, LLC, Trenton...

The Effects of Conductivity on High-Resolution Impulse Radar Sounding, Ross Ice Shelf, Antarctica,

DTIC Science & Technology

1982-12-01

OFSTNDRS96- - . -t - . J’-t -. -t-t ---- . f- t..- -.f ~ *~~ "EPORDT82-42 US Army CorpsREPORT 82of Engineers Cold Regions Research &Engineering...bottom of the Ross Ice Shelf at Site J-9, 2) detecting the preferred horizontal c-axis azi- muthal’direction of the sea ice crystals, using the...which drilling revealed to be 416 m below the snow surface. The radar system was used to profile the McMurdo Ice Shelf both from the snow surface and

Mineral/Water Analyzer

NASA Technical Reports Server (NTRS)

1983-01-01

An x-ray fluorescence spectrometer developed for the Viking Landers by Martin Marietta was modified for geological exploration, water quality monitoring, and aircraft engine maintenance. The aerospace system was highly miniaturized and used very little power. It irradiates the sample causing it to emit x-rays at various energies, then measures the energy levels for sample composition analysis. It was used in oceanographic applications and modified to identify element concentrations in ore samples, on site. The instrument can also analyze the chemical content of water, and detect the sudden development of excessive engine wear.

Quality analysis of patient information about knee arthroscopy on the World Wide Web.

PubMed

Sambandam, Senthil Nathan; Ramasamy, Vijayaraj; Priyanka, Priyanka; Ilango, Balakrishnan

2007-05-01

This study was designed to ascertain the quality of patient information available on the World Wide Web on the topic of knee arthroscopy. For the purpose of quality analysis, we used a pool of 232 search results obtained from 7 different search engines. We used a modified assessment questionnaire to assess the quality of these Web sites. This questionnaire was developed based on similar studies evaluating Web site quality and includes items on illustrations, accessibility, availability, accountability, and content of the Web site. We also compared results obtained with different search engines and tried to establish the best possible search strategy to attain the most relevant, authentic, and adequate information with minimum time consumption. For this purpose, we first compared 100 search results from the single most commonly used search engine (AltaVista) with the pooled sample containing 20 search results from each of the 7 different search engines. The search engines used were metasearch (Copernic and Mamma), general search (Google, AltaVista, and Yahoo), and health topic-related search engines (MedHunt and Healthfinder). The phrase "knee arthroscopy" was used as the search terminology. Excluding the repetitions, there were 117 Web sites available for quality analysis. These sites were analyzed for accessibility, relevance, authenticity, adequacy, and accountability by use of a specially designed questionnaire. Our analysis showed that most of the sites providing patient information on knee arthroscopy contained outdated information, were inadequate, and were not accountable. Only 16 sites were found to be providing reasonably good patient information and hence can be recommended to patients. Understandably, most of these sites were from nonprofit organizations and educational institutions. Furthermore, our study revealed that using multiple search engines increases patients' chances of obtaining more relevant information rather than using a single search engine. Our study shows the difficulties encountered by patients in obtaining information regarding knee arthroscopy and highlights the duty of knee surgeons in helping patients to identify the relevant and authentic information in the most efficient manner from the World Wide Web. This study highlights the importance of the role of orthopaedic surgeons in helping their patients to identify the best possible information on the World Wide Web.

Data collected to support monitoring of constructed emergent sandbar habitat on the Missouri River downstream from Gavins Point Dam, South Dakota and Nebraska, 2004-06

USGS Publications Warehouse

Thompson, Ryan F.; Johnson, Michaela R.; Andersen, Michael J.

2007-01-01

The U.S. Army Corps of Engineers has constructed emergent sandbar habitat on sections of the Missouri River bordering South Dakota and Nebraska downstream from Gavins Point Dam to create and enhance habitat for threatened and endangered bird species. Two areas near river miles 761.3 and 769.8 were selected for construction of emergent sandbar habitat. Pre- and postconstruction data were collected by the U.S. Geological Survey, in cooperation with the U.S. Army Corps of Engineers, to evaluate the success of the habitat management techniques. Data collected include pre- and postconstruction channel-geometry data (bathymetric and topographic) for areas upstream from, downstream from, and within each construction site. Water-velocity data were collected for selected parts of the site near river mile 769.8. Instruments and methods used in data collection, as well as quality-assurance and quality-control measures, are described. Geospatial channel-geometry data are presented for transects of the river channel as cross sections and as geographical information system shapefiles. Geospatial land-surface elevation data are provided for part of each site in the form of a color-shaded relief map. Geospatial water-velocity data also are provided as color-shaded maps and geographical information system shapefiles.

Yakima/Klickitat Production Preliminary Design Report, Appendix C: Yakima and Klickitat Preliminary Engineering Reports.

DOE Office of Scientific and Technical Information (OSTI.GOV)

CH2M Hill; R.W. Beck and Associates.

1990-03-01

This chapter describes the biological and physical fish culture requirements of the hatchery system from which the concepts for the design are formulated. It includes a discussion of the program goals for fish production in the Yakima Basin followed by a brief summary of selected sites. The biological criteria are presented for the water system, adult holding, incubation, rearing, and finally transportation and release. The biological criteria address the water and space requirements, the number and type of vessels, and the related support requirements. To be assured that the components of the system meet all program demands, each life phasemore » from adult capture to the juvenile or smolt transfer into the acclimation sites is analyzed.« less

Lidar Sensor Performance in Closed-Loop Flight Testing of the Morpheus Rocket-Propelled Lander to a Lunar-Like Hazard Field

NASA Technical Reports Server (NTRS)

Roback, V. Eric; Pierrottet, Diego F.; Amzajerdian, Farzin; Barnes, Bruce W.; Bulyshev, Alexander E.; Hines, Glenn D.; Petway, Larry B.; Brewster, Paul F.; Kempton, Kevin S.

2015-01-01

For the first time, a suite of three lidar sensors have been used in flight to scan a lunar-like hazard field, identify a safe landing site, and, in concert with an experimental Guidance, Navigation, and Control (GN&C) system, help to guide the Morpheus autonomous, rocket-propelled, free-flying lander to that safe site on the hazard field. The lidar sensors and GN&C system are part of the Autonomous Precision Landing and Hazard Detection and Avoidance Technology (ALHAT) project which has been seeking to develop a system capable of enabling safe, precise crewed or robotic landings in challenging terrain on planetary bodies under any ambient lighting conditions. The 3-D imaging Flash Lidar is a second generation, compact, real-time, aircooled instrument developed from a number of components from industry and NASA and is used as part of the ALHAT Hazard Detection System (HDS) to scan the hazard field and build a 3-D Digital Elevation Map (DEM) in near-real time for identifying safe sites. The Flash Lidar is capable of identifying a 30 cm hazard from a slant range of 1 km with its 8 cm range precision (1-s). The Flash Lidar is also used in Hazard Relative Navigation (HRN) to provide position updates down to a 250m slant range to the ALHAT navigation filter as it guides Morpheus to the safe site. The Navigation Doppler Lidar (NDL) system has been developed within NASA to provide velocity measurements with an accuracy of 0.2 cm/sec and range measurements with an accuracy of 17 cm both from a maximum range of 2,200 m to a minimum range of several meters above the ground. The NDLâ€"TM"s measurements are fed into the ALHAT navigation filter to provide lander guidance to the safe site. The Laser Altimeter (LA), also developed within NASA, provides range measurements with an accuracy of 5 cm from a maximum operational range of 30 km down to 1 m and, being a separate sensor from the Flash Lidar, can provide range along a separate vector. The LA measurements are also fed into the ALHAT navigation filter to provide lander guidance to the safe site. The flight tests served as the culmination of the TRL 6 journey for the ALHAT system and included launch from a pad situated at the NASA-Kennedy Space Center Shuttle Landing Facility (SLF) runway, a lunar-like descent trajectory from an altitude of 250m, and landing on a lunar-like hazard field of rocks, craters, hazardous slopes, and safe sites 400m down-range just off the North end of the runway. The tests both confirmed the expected performance and also revealed several challenges present in the flight-like environment which will feed into future TRL advancement of the sensors. Guidance provided by the ALHAT system was impeded in portions of the trajectory and intermittent near the end of the trajectory due to optical effects arising from air heated by the rocket engine. The Flash Lidar identified hazards as small as 30 cm from the maximum slant range of 450 m which Morpheus could provide; however, it was occasionally susceptible to an increase in range noise due to scintillation arising from air heated by the Morpheus rocket engine which entered its Field-of-View (FOV). The Flash Lidar was also susceptible to pre-triggering, during the HRN phase, on a dust cloud created during launch and transported down-range by the wind. The NDL provided velocity and range measurements to the expected accuracy levels yet it was also susceptible to signal degradation due to air heated by the rocket engine. The LA, operating with a degraded transmitter laser, also showed signal attenuation over a few seconds at a specific phase of the flight due to the heat plume generated by the rocket engine.

Ocean Instruments Web Site for Undergraduate, Secondary and Informal Education

NASA Astrophysics Data System (ADS)

Farrington, J. W.; Nevala, A.; Dolby, L. A.

2004-12-01

An Ocean Instruments web site has been developed that makes available information about ocean sampling and measurement instruments and platforms. The site features text, pictures, diagrams and background information written or edited by experts in ocean science and engineering and contains links to glossaries and multimedia technologies including video streaming, audio packages, and searchable databases. The site was developed after advisory meetings with selected professors teaching undergraduate classes who responded to the question, what could Woods Hole Oceanographic Institution supply to enhance undergraduate education in ocean sciences, life sciences, and geosciences? Prototypes were developed and tested with students, potential users, and potential contributors. The site is hosted by WHOI. The initial five instruments featured were provided by four WHOI scientists and engineers and by one Sea Education Association faculty member. The site is now open to contributions from scientists and engineers worldwide. The site will not advertise or promote the use of individual ocean instruments.

Aerial View of NACA's Lewis Flight Propulsion Research Laboratory

NASA Image and Video Library

1946-05-21

The National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory in Cleveland, Ohio as seen from the west in May 1946. The Cleveland Municipal Airport is located directly behind. The laboratory was built in the early 1940s to resolve problems associated with aircraft engines. The initial campus contained seven principal buildings: the Engine Research Building, hangar, Fuels and Lubricants Building, Administration Building, Engine Propeller Research Building, Altitude Wind Tunnel, and Icing Research Tunnel. These facilities and their associated support structures were located within an area occupying approximately one-third of the NACA’s property. After World War II ended, the NACA began adding new facilities to address different problems associated with the newer, more powerful engines and high speed flight. Between 1946 and 1955, four new world-class test facilities were built: the 8- by 6-Foot Supersonic Wind Tunnel, the Propulsion Systems Laboratory, the Rocket Engine Test Facility, and the 10- by 10-Foot Supersonic Wind Tunnel. These large facilities occupied the remainder of the NACA’s semicircular property. The Lewis laboratory expanded again in the late 1950s and early 1960s as the space program commenced. Lewis purchased additional land in areas adjacent to the original laboratory and acquired a large 9000-acre site located 60 miles to the west in Sandusky, Ohio. The new site became known as Plum Brook Station.

An Enhanced Engineering Perspective of Global Climate Systems and Statistical Formulation of Terrestrial CO2 Exchanges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dai, Yuanshun; Baek, Seung H.; Garcia-Diza, Alberto

2012-01-01

This paper designs a comprehensive approach based on the engineering machine/system concept, to model, analyze, and assess the level of CO2 exchange between the atmosphere and terrestrial ecosystems, which is an important factor in understanding changes in global climate. The focus of this article is on spatial patterns and on the correlation between levels of CO2 fluxes and a variety of influencing factors in eco-environments. The engineering/machine concept used is a system protocol that includes the sequential activities of design, test, observe, and model. This concept is applied to explicitly include various influencing factors and interactions associated with CO2 fluxes.more » To formulate effective models of a large and complex climate system, this article introduces a modeling technique that will be referred to as Stochastic Filtering Analysis of Variance (SFANOVA). The CO2 flux data observed from some sites of AmeriFlux are used to illustrate and validate the analysis, prediction and globalization capabilities of the proposed engineering approach and the SF-ANOVA technology. The SF-ANOVA modeling approach was compared to stepwise regression, ridge regression, and neural networks. The comparison indicated that the proposed approach is a valid and effective tool with similar accuracy and less complexity than the other procedures.« less

Assessment and evaluation of engineering options at a low-level radioactive waste storage site

NASA Astrophysics Data System (ADS)

Kanehiro, B. Y.; Guvanasen, V.

1982-09-01

Solutions to hydrologic and geotechnical problems associated with existing disposal sites were sought and the efficiency of engineering options that were proposed to improve the integrity of such sites were evaluated. The Weldon Spring site is generally like other low-level nuclear waste sites, except that the wastes are primarily in the form of residues and contaminated rubble from the processing of uranium and thorium ores rather than industrial isotopes or mill tailings.

Superfund Public Information System (SPIS), June 1998 (on CD-ROM). Data file

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-06-01

The Superfund Public Information System (SPIS) on CD-ROM contains Superfund data for the United States Environmental Protection Agency. The Superfund data is a collection of four databases, CERCLIS, Archive (NFRAP), RODS, and NPL Sites. Descriptions of these databases and CD contents are listed below. The FolioViews browse and retrieval engine is used as a graphical interface to the data. Users can access simple queries and can do complex searching on key words or fields. In addition, context sensitive help, a Superfund process overview, and an integrated data dictionary are available. RODS is the Records Of Decision System. RODS is usedmore » to track site clean-ups under the Superfund program to justify the type of treatment chosen at each site. RODS contains information on technology justification, site history, community participation, enforcement activities, site characteristics, scope and role of response action, and remedy. Explanation of Significant Differences (ESDs) are also available on the CD. CERCLIS is the Comprehensive Environmental Response, Compensation, and Liability Information System. It is the official repository for all Superfund site and incident data. It contains comprehensive information on hazardous waste sites, site inspections, preliminary assessments, and remedial status. The system is sponsored by the EPA`s Office of Emergency and Remedial Response, Information Management Center. Archive (NFRAP) consists of hazardous waste sites that have no further remedial action planned; only basic identifying information is provided for archive sites. The sites found in the Archive database were originally in the CERCLIS database, but were removed beginning in the fall of 1995. NPL sites (available online) are fact sheets that describe the location and history of Superfund sites. Included are descriptions of the most recent activities and past actions at the sites that have contributed to the contamination. Population estimates, land usages, and nearby resources give background on the local setting surrounding a site.« less

Upcoming Events

Science.gov Websites

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z D2L PAWS Email My UW-System About UWM UWM Jobs D2L PAWS Email My UW-System University of Wisconsin-Milwaukee College ofEngineering & Olympiad Girls Who Code Club FIRST Tech Challenge NSF I-Corps Site of Southeastern Wisconsin UW-Milwaukee

Small Reactor for Deep Space Exploration

ScienceCinema

none,

2018-06-06

This is the first demonstration of a space nuclear reactor system to produce electricity in the United States since 1965, and an experiment demonstrated the first use of a heat pipe to cool a small nuclear reactor and then harvest the heat to power a Stirling engine at the Nevada National Security Site's Device Assembly Facility confirms basic nuclear reactor physics and heat transfer for a simple, reliable space power system.

A New Approach to Site Demand-Based Level Inventory Optimization

DTIC Science & Technology

2016-06-01

Command (2016) Navy supply chain management. Accessed April 17, 2016, https://www.navsup.navy.mil/navsup/capabilities/nscm Salmeron J, Craparo E (2016...Engineering 53: 122-142. Naval Supply Systems Command (2016a) Navy supply chain management. Accessed April 17, 2016, https://www.navsup.navy.mil...distribution is unlimited 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) Naval Supply Systems Command (NAVSUP) supports Navy, Marine Corps

Penetrator role in Mars sample strategy

NASA Technical Reports Server (NTRS)

Boynton, William; Dwornik, Steve; Eckstrom, William; Roalstad, David A.

1988-01-01

The application of the penetrator to a Mars Return Sample Mission (MRSM) has direct advantages to meet science objectives and mission safety. Based on engineering data and work currently conducted at Ball Aerospace Systems Division, the concept of penetrators as scientific instruments is entirely practical. The primary utilization of a penetrator for MRSM would be to optimize the selection of the sample site location and to help in selection of the actual sample to be returned to Earth. It is recognized that the amount of sample to be returned is very limited, therefore the selection of the sample site is critical to the success of the mission. The following mission scenario is proposed. The site selection of a sample to be acquired will be performed by science working groups. A decision will be reached and a set of target priorities established based on data to give geochemical, geophysical and geological information. The first task of a penetrator will be to collect data at up to 4 to 6 possible landing sites. The penetrator can include geophysical, geochemical, geological and engineering instruments to confirm that scientific data requirements at that site will be met. This in situ near real-time data, collected prior to final targeting of the lander, will insure that the sample site is both scientifically valuable and also that it is reachable within limits of the capability of the lander.

76 FR 38383 - Albany Engineering Corporation, Town of Stuyvesant, NY; Notice of Site Visit and Technical Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Project No. 2696-033] Albany Engineering Corporation, Town of Stuyvesant, NY; Notice of Site Visit and Technical Meeting On July 12, 2011, Office of Energy Projects staff will participate in a site visit and technical meeting for the Stuyvesant...

Discovering How Students Search a Library Web Site: A Usability Case Study.

ERIC Educational Resources Information Center

Augustine, Susan; Greene, Courtney

2002-01-01

Discusses results of a usability study at the University of Illinois Chicago that investigated whether Internet search engines have influenced the way students search library Web sites. Results show students use the Web site's internal search engine rather than navigating through the pages; have difficulty interpreting library terminology; and…

Use of an Academic Library Web Site Search Engine.

ERIC Educational Resources Information Center

Fagan, Jody Condit

2002-01-01

Describes an analysis of the search engine logs of Southern Illinois University, Carbondale's library to determine how patrons used the site search. Discusses results that showed patrons did not understand the function of the search and explains improvements that were made in the Web site and in online reference services. (Author/LRW)

76 FR 27366 - Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plants #1 And #2, Including On-Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-75,023] Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plants 1 And 2, Including On-Site Leased Workers from Caravan... 6, 2011, applicable to workers of Chrysler Group, LLC, Power Train Division, Mack Avenue Engine...

Surface-water data and statistics from U.S. Geological Survey data-collection networks in New Jersey on the World Wide Web

USGS Publications Warehouse

Reiser, Robert G.; Watson, Kara M.; Chang, Ming; Nieswand, Steven P.

2002-01-01

The U.S. Geological Survey (USGS), in cooperation with other Federal, State, and local agencies, operates and maintains a variety of surface-water data-collection networks throughout the State of New Jersey. The networks include streamflow-gaging stations, low-flow sites, crest-stage gages, tide gages, tidal creststage gages, and water-quality sampling sites. Both real-time and historical surface-water data for many of the sites in these networks are available at the USGS, New Jersey District, web site (http://nj.usgs.gov/), and water-quality data are available at the USGS National Water Information System (NWIS) web site (http://waterdata.usgs.gov/nwis/). These data are an important source of information for water managers, engineers, environmentalists, and private citizens.

Predicting long-term performance of engineered geologic carbon dioxide storage systems to inform decisions amidst uncertainty

NASA Astrophysics Data System (ADS)

Pawar, R.

2016-12-01

Risk assessment and risk management of engineered geologic CO2 storage systems is an area of active investigation. The potential geologic CO2 storage systems currently under consideration are inherently heterogeneous and have limited to no characterization data. Effective risk management decisions to ensure safe, long-term CO2 storage requires assessing and quantifying risks while taking into account the uncertainties in a storage site's characteristics. The key decisions are typically related to definition of area of review, effective monitoring strategy and monitoring duration, potential of leakage and associated impacts, etc. A quantitative methodology for predicting a sequestration site's long-term performance is critical for making key decisions necessary for successful deployment of commercial scale geologic storage projects where projects will require quantitative assessments of potential long-term liabilities. An integrated assessment modeling (IAM) paradigm which treats a geologic CO2 storage site as a system made up of various linked subsystems can be used to predict long-term performance. The subsystems include storage reservoir, seals, potential leakage pathways (such as wellbores, natural fractures/faults) and receptors (such as shallow groundwater aquifers). CO2 movement within each of the subsystems and resulting interactions are captured through reduced order models (ROMs). The ROMs capture the complex physical/chemical interactions resulting due to CO2 movement and interactions but are computationally extremely efficient. The computational efficiency allows for performing Monte Carlo simulations necessary for quantitative probabilistic risk assessment. We have used the IAM to predict long-term performance of geologic CO2 sequestration systems and to answer questions related to probability of leakage of CO2 through wellbores, impact of CO2/brine leakage into shallow aquifer, etc. Answers to such questions are critical in making key risk management decisions. A systematic uncertainty quantification approach can been used to understand how uncertain parameters associated with different subsystems (e.g., reservoir permeability, wellbore cement permeability, wellbore density, etc.) impact the overall site performance predictions.

Dissecting the active site of a photoreceptor protein

NASA Astrophysics Data System (ADS)

Hoff, Wouter; Hara, Miwa; Ren, Jie; Moghadam, Farzaneh; Xie, Aihua; Kumauchi, Masato

While enzymes are quite large molecules, functionally important chemical events are often limited to a small region of the protein: the active site. The physical and chemical properties of residues at such active sites are often strongly altered compared to the same groups dissolved in water. Understanding such effects is important for unraveling the mechanisms underlying protein function and for protein engineering, but has proven challenging. Here we report on our ongoing efforts on using photoactive yellow protein (PYP), a bacterial photoreceptor, as a model system for such effects. We will report on the following questions: How many residues affect active site properties? Are these residues in direct physical contact with the active site? Can functionally important residues be recognized in the crystal structure of a protein? What structural resolution is needed to understand active sites? What spectroscopic techniques are most informative? Which weak interactions dominate active site properties?

Implementation of a DOD ELAP Conforming Quality System at a FUSRAP Site Field Temporary Radiological Screening Laboratory - 13500

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winters, M.S.; McElheny, G.; Houston, L.M.

2013-07-01

A case study is presented on specific program elements that supported the transition of a temporary field radiological screening lab to an accredited operation capable of meeting client quality objectives for definitive results data. The temporary field lab is located at the Formerly Utilized Sites Remedial Action Program Linde Site in Tonawanda, NY. The site is undergoing remediation under the direction of the United States Army Corps of Engineers - Buffalo District, with Cabrera Services Inc. as the remediation contractor and operator of the on-site lab. Analysis methods employed in the on-site lab include gross counting of alpha and betamore » particle activity on swipes and air filters and gamma spectroscopy of soils and other solid samples. A discussion of key program elements and lessons learned may help other organizations considering pursuit of accreditation for on-site screening laboratories. (authors)« less

Applications of Ecological Engineering Remedies for Uranium Processing Sites, USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waugh, William

The U.S. Department of Energy (USDOE) is responsible for remediation of environmental contamination and long-term stewardship of sites associated with the legacy of nuclear weapons production during the Cold War in the United States. Protection of human health and the environment will be required for hundreds or even thousands of years at many legacy sites. USDOE continually evaluates and applies advances in science and technology to improve the effectiveness and sustainability of surface and groundwater remedies (USDOE 2011). This paper is a synopsis of ecological engineering applications that USDOE is evaluating to assess the effectiveness of remedies at former uraniummore » processing sites in the southwestern United States. Ecological engineering remedies are predicated on the concept that natural ecological processes at legacy sites, once understood, can be beneficially enhanced or manipulated. Advances in tools for characterizing key processes and for monitoring remedy performance are demonstrating potential. We present test cases for four ecological engineering remedies that may be candidates for international applications.« less

Cell-free synthetic biology for in vitro prototype engineering.

PubMed

Moore, Simon J; MacDonald, James T; Freemont, Paul S

2017-06-15

Cell-free transcription-translation is an expanding field in synthetic biology as a rapid prototyping platform for blueprinting the design of synthetic biological devices. Exemplar efforts include translation of prototype designs into medical test kits for on-site identification of viruses (Zika and Ebola), while gene circuit cascades can be tested, debugged and re-designed within rapid turnover times. Coupled with mathematical modelling, this discipline lends itself towards the precision engineering of new synthetic life. The next stages of cell-free look set to unlock new microbial hosts that remain slow to engineer and unsuited to rapid iterative design cycles. It is hoped that the development of such systems will provide new tools to aid the transition from cell-free prototype designs to functioning synthetic genetic circuits and engineered natural product pathways in living cells. © 2017 The Author(s).

Cell-free synthetic biology for in vitro prototype engineering

PubMed Central

Moore, Simon J.; MacDonald, James T.

2017-01-01

Cell-free transcription–translation is an expanding field in synthetic biology as a rapid prototyping platform for blueprinting the design of synthetic biological devices. Exemplar efforts include translation of prototype designs into medical test kits for on-site identification of viruses (Zika and Ebola), while gene circuit cascades can be tested, debugged and re-designed within rapid turnover times. Coupled with mathematical modelling, this discipline lends itself towards the precision engineering of new synthetic life. The next stages of cell-free look set to unlock new microbial hosts that remain slow to engineer and unsuited to rapid iterative design cycles. It is hoped that the development of such systems will provide new tools to aid the transition from cell-free prototype designs to functioning synthetic genetic circuits and engineered natural product pathways in living cells. PMID:28620040

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells.

PubMed

Lee, Ciaran M; Cradick, Thomas J; Bao, Gang

2016-03-01

The clustered regularly-interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) system from Streptococcus pyogenes (Spy) has been successfully adapted for RNA-guided genome editing in a wide range of organisms. However, numerous reports have indicated that Spy CRISPR-Cas9 systems may have significant off-target cleavage of genomic DNA sequences differing from the intended on-target site. Here, we report the performance of the Neisseria meningitidis (Nme) CRISPR-Cas9 system that requires a longer protospacer-adjacent motif for site-specific cleavage, and present a comparison between the Spy and Nme CRISPR-Cas9 systems targeting the same protospacer sequence. The results with the native crRNA and tracrRNA as well as a chimeric single guide RNA for the Nme CRISPR-Cas9 system were also compared. Our results suggest that, compared with the Spy system, the Nme CRISPR-Cas9 system has similar or lower on-target cleavage activity but a reduced overall off-target effect on a genomic level when sites containing three or fewer mismatches are considered. Thus, the Nme CRISPR-Cas9 system may represent a safer alternative for precision genome engineering applications.

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells

PubMed Central

Lee, Ciaran M; Cradick, Thomas J; Bao, Gang

2016-01-01

The clustered regularly-interspaced short palindromic repeats (CRISPR)—CRISPR-associated (Cas) system from Streptococcus pyogenes (Spy) has been successfully adapted for RNA-guided genome editing in a wide range of organisms. However, numerous reports have indicated that Spy CRISPR-Cas9 systems may have significant off-target cleavage of genomic DNA sequences differing from the intended on-target site. Here, we report the performance of the Neisseria meningitidis (Nme) CRISPR-Cas9 system that requires a longer protospacer-adjacent motif for site-specific cleavage, and present a comparison between the Spy and Nme CRISPR-Cas9 systems targeting the same protospacer sequence. The results with the native crRNA and tracrRNA as well as a chimeric single guide RNA for the Nme CRISPR-Cas9 system were also compared. Our results suggest that, compared with the Spy system, the Nme CRISPR-Cas9 system has similar or lower on-target cleavage activity but a reduced overall off-target effect on a genomic level when sites containing three or fewer mismatches are considered. Thus, the Nme CRISPR-Cas9 system may represent a safer alternative for precision genome engineering applications. PMID:26782639

Inspection system qualification and integration into the mask manufacturing environment

NASA Astrophysics Data System (ADS)

LaVoy, Rosanne; Fujioka, Ron

1995-12-01

Integration of a mask inspection system into a manufacturing environment poses new challenges to both the inspection engineer and the equipment supplier. Traditional specifications (limited primarily to sensitivity and uptime) are no longer sufficient to successfully integrate a system into a 7 by 24 manufacturing area with multiple systems. Issues such as system sensitivity matching, sensitivity characterization by defect type, operator training and certification standards, and real-time SPC control of the systems must be addressed. This paper outlines some of the techniques Intel Mask Operation uses for integration of a new inspection system into the manufacturing line. Specifically moving a beta- site type tool out of the beta-site mode and into volume production. Examples are presented, including installation for manufacturing (including ergonomic modifications), techniques for system-to-system matching, use of SPC charts to monitor system performance, and operator training/certifications. Relationships between system PMs, or other environmental changes, and the system sensitivity SPC control charts also are discussed.

46 CFR 310.58 - Service obligation for students executing or reexecuting contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... repair; municipal and State port authorities; and port development, marine engineering, and tug and barge... MARAD using the web-based Internet system at https://mscs.marad.dot.gov. Reports may also be mailed to... and Plans by logging into the service obligation contract compliance Web site at http://mscs.marad.dot...

46 CFR 310.58 - Service obligation for students executing or reexecuting contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... repair; municipal and State port authorities; and port development, marine engineering, and tug and barge... MARAD using the web-based Internet system at https://mscs.marad.dot.gov. Reports may also be mailed to... and Plans by logging into the service obligation contract compliance Web site at http://mscs.marad.dot...

DEVELOPMENT OF COMMUNITY POWER FROM SUSTAINABLE SMALL HYDRO POWER SYSTEMS – A CAPACITY BUILDING PROJECT IN BANGANG, CAMEROON

EPA Science Inventory

The hydro-turbine developed in Phase I will be fabricated on-site in Bangang, Cameroon using locally sourced materials. Data of the performance tests will be collected and analyzed using appropriate engineering analysis tools. A second trip will be planned for extensive testin...

6. INTERIOR VIEW TO THE EAST OF SOUTHEAST CORNER OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. INTERIOR VIEW TO THE EAST OF SOUTHEAST CORNER OF THE HOT BAY. A LARGE MANIPULATOR ARM AND HORIZONTAL TRACKING SYSTEM IS SHOWN ABOVE SMALLER MANIPULATOR ARM WORK STATIONS. ASSOCIATED WITH THE WORK STATIONS ARE OBSERVATION WINDOWS. - Nevada Test Site, Engine Maintenance Assembly & Disassembly Facility, Area 25, Jackass Flats, Mercury, Nye County, NV

Land Application of Wastes: An Educational Program. Pathogens - Module 9.

ERIC Educational Resources Information Center

Clarkson, W. W.; And Others

This module is intended to help engineers evaluate the relative health risks from pathogens at land treatment sites versus conventional waste treatment systems. Among the topics considered are the following: (1) the relationship between survival time of pathogens and the chance of disease transmission to humans; (2) the factors that favor survival…

KSC-2011-7934

NASA Image and Video Library

2011-11-25

CAPE CANAVERAL, Fla. – Betina Pavri, systems engineer at NASA's Jet Propulsion Laboratory (JPL), speaks to a group of Tweetup participants at NASA Kennedy Space Center's Press Site in Florida during prelaunch activities for the agency’s Mars Science Laboratory (MSL) launch as Allen Chen, also a systems engineer at JPL, looks on, at left. Following a series of briefings, participants will tour the center and get a close-up view of Space Launch Complex-41 on Cape Canaveral Air Force Station. The tweeters will share their experiences with followers through the social networking site Twitter. MSL's components include a car-sized rover, Curiosity, which has 10 science instruments designed to search for signs of life, including methane, and help determine if the gas is from a biological or geological source. Liftoff of MSL aboard a United Launch Alliance Atlas V rocket from pad 41 is planned during a launch window which extends from 10:02 a.m. to 11:45 a.m. EST on Nov. 26. For more information, visit http://www.nasa.gov/msl. Photo credit: NASA/Jim Grossmann

Systemic Propagation of a Fluorescent Infectious Clone of a Polerovirus Following Inoculation by Agrobacteria and Aphids

PubMed Central

Boissinot, Sylvaine; Pichon, Elodie; Sorin, Céline; Piccini, Céline; Scheidecker, Danièle; Ziegler-Graff, Véronique; Brault, Véronique

2017-01-01

A fluorescent viral clone of the polerovirus Turnip yellows virus (TuYV) was engineered by introducing the Enhanced Green Fluorescent Protein (EGFP) sequence into the non-structural domain sequence of the readthrough protein, a minor capsid protein. The resulting recombinant virus, referred to as TuYV-RTGFP, was infectious in several plant species when delivered by agroinoculation and invaded efficiently non-inoculated leaves. As expected for poleroviruses, which infect only phloem cells, the fluorescence emitted by TuYV-RTGFP was restricted to the vasculature of infected plants. In addition, TuYV-RTGFP was aphid transmissible and enabled the observation of the initial sites of infection in the phloem after aphid probing in epidermal cells. The aphid-transmitted virus moved efficiently to leaves distant from the inoculation sites and importantly retained the EGFP sequence in the viral genome. This work reports on the first engineered member in the Luteoviridae family that can be visualized by fluorescence emission in systemic leaves of different plant species after agroinoculation or aphid transmission. PMID:28661469

Systemic Propagation of a Fluorescent Infectious Clone of a Polerovirus Following Inoculation by Agrobacteria and Aphids.

PubMed

Boissinot, Sylvaine; Pichon, Elodie; Sorin, Céline; Piccini, Céline; Scheidecker, Danièle; Ziegler-Graff, Véronique; Brault, Véronique

2017-06-29

A fluorescent viral clone of the polerovirus Turnip yellows virus (TuYV) was engineered by introducing the Enhanced Green Fluorescent Protein (EGFP) sequence into the non-structural domain sequence of the readthrough protein, a minor capsid protein. The resulting recombinant virus, referred to as TuYV-RT GFP , was infectious in several plant species when delivered by agroinoculation and invaded efficiently non-inoculated leaves. As expected for poleroviruses, which infect only phloem cells, the fluorescence emitted by TuYV-RT GFP was restricted to the vasculature of infected plants. In addition, TuYV-RT GFP was aphid transmissible and enabled the observation of the initial sites of infection in the phloem after aphid probing in epidermal cells. The aphid-transmitted virus moved efficiently to leaves distant from the inoculation sites and importantly retained the EGFP sequence in the viral genome. This work reports on the first engineered member in the Luteoviridae family that can be visualized by fluorescence emission in systemic leaves of different plant species after agroinoculation or aphid transmission.

Leadership and Stewardship of the Laboratory (Objective 4.1) Notable Outcome - Phase II Alternative Analysis and PNNL Site Plan Recommendation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pittman, Jeffery P.; Cassidy, Stephen R.; Mosey, Whitney LC

2013-07-31

Pacific Northwest National Laboratory (PNNL) and the Pacific Northwest Site Office (PNSO) have recently completed an effort to identify the current state of the campus and gaps that exist with regards to space needs, facilities and infrastructure. This effort has been used to establish a campus strategy to ensure PNNL is ready to further the United States (U.S.) Department of Energy (DOE) mission. Ten-year business projections and the impacts on space needs were assessed and incorporated into the long-term facility plans. In identifying/quantifying the space needs for PNNL, the following categories were addressed: Multi-purpose Programmatic (wet chemistry and imaging laboratorymore » space), Strategic (Systems Engineering and Computation Analytics, and Collaboration space), Remediation (space to offset the loss of the Research Technology Laboratory [RTL] Complex due to decontamination and demolition), and Optimization (the exit of older and less cost-effective facilities). The findings of the space assessment indicate a need for wet chemistry space, imaging space, and strategic space needs associated with systems engineering and collaboration space.« less

The Ensembl genome database project.

PubMed

Hubbard, T; Barker, D; Birney, E; Cameron, G; Chen, Y; Clark, L; Cox, T; Cuff, J; Curwen, V; Down, T; Durbin, R; Eyras, E; Gilbert, J; Hammond, M; Huminiecki, L; Kasprzyk, A; Lehvaslaiho, H; Lijnzaad, P; Melsopp, C; Mongin, E; Pettett, R; Pocock, M; Potter, S; Rust, A; Schmidt, E; Searle, S; Slater, G; Smith, J; Spooner, W; Stabenau, A; Stalker, J; Stupka, E; Ureta-Vidal, A; Vastrik, I; Clamp, M

2002-01-01

The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organise biology around the sequences of large genomes. It is a comprehensive source of stable automatic annotation of the human genome sequence, with confirmed gene predictions that have been integrated with external data sources, and is available as either an interactive web site or as flat files. It is also an open source software engineering project to develop a portable system able to handle very large genomes and associated requirements from sequence analysis to data storage and visualisation. The Ensembl site is one of the leading sources of human genome sequence annotation and provided much of the analysis for publication by the international human genome project of the draft genome. The Ensembl system is being installed around the world in both companies and academic sites on machines ranging from supercomputers to laptops.

Macroscale delivery systems for molecular and cellular payloads

NASA Astrophysics Data System (ADS)

Kearney, Cathal J.; Mooney, David J.

2013-11-01

Macroscale drug delivery (MDD) devices are engineered to exert spatiotemporal control over the presentation of a wide range of bioactive agents, including small molecules, proteins and cells. In contrast to systemically delivered drugs, MDD systems act as a depot of drug localized to the treatment site, which can increase drug effectiveness while reducing side effects and confer protection to labile drugs. In this Review, we highlight the key advantages of MDD systems, describe their mechanisms of spatiotemporal control and provide guidelines for the selection of carrier materials. We also discuss the combination of MDD technologies with classic medical devices to create multifunctional MDD devices that improve integration with host tissue, and the use of MDD technology in tissue-engineering strategies to direct cell behaviour. As our ever-expanding knowledge of human biology and disease provides new therapeutic targets that require precise control over their application, the importance of MDD devices in medicine is expected to increase.

78 FR 38672 - Ocean Dumping; Sabine-Neches Waterway (SNWW) Ocean Dredged Material Disposal Site Designation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... March 2011 prepared by the U.S. Army Corps of Engineers (also Corps or USACE). Appendix B of Volume III... be considered on the proposed site designations. The U.S. Army Corps of Engineers Final EIS for the... of dredged material from the Sabine-Neches Waterway. Currently, the US Army Corps of Engineers will...

Space shuttle three main engine return to launch site abort

NASA Technical Reports Server (NTRS)

Carter, J. F.; Bown, R. L.

1975-01-01

A Return-to-Launch-Site (RTLS) abort with three Space Shuttle Main Engines (SSME) operational was examined. The results are trajectories and main engine cutoff conditions that are approximately the same as for a two SSME case. Requiring the three SSME solution to match the two SSME abort eliminates additional crew training and is accomplished with negligible software impact.

Cost estimation and analysis using the Sherpa Automated Mine Cost Engineering System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stebbins, P.E.

1993-09-01

The Sherpa Automated Mine Cost Engineering System is a menu-driven software package designed to estimate capital and operating costs for proposed surface mining operations. The program is engineering (as opposed to statistically) based, meaning that all equipment, manpower, and supply requirements are determined from deposit geology, project design and mine production information using standard engineering techniques. These requirements are used in conjunction with equipment, supply, and labor cost databases internal to the program to estimate all associated costs. Because virtually all on-site cost parameters are interrelated within the program, Sherpa provides an efficient means of examining the impact of changesmore » in the equipment mix on total capital and operating costs. If any aspect of the operation is changed, Sherpa immediately adjusts all related aspects as necessary. For instance, if the user wishes to examine the cost ramifications of selecting larger trucks, the program not only considers truck purchase and operation costs, it also automatically and immediately adjusts excavator requirements, operator and mechanic needs, repair facility size, haul road construction and maintenance costs, and ancillary equipment specifications.« less

Engineering Promoter Architecture in Oleaginous Yeast Yarrowia lipolytica.

PubMed

Shabbir Hussain, Murtaza; Gambill, Lauren; Smith, Spencer; Blenner, Mark A

2016-03-18

Eukaryotic promoters have a complex architecture to control both the strength and timing of gene transcription spanning up to thousands of bases from the initiation site. This complexity makes rational fine-tuning of promoters in fungi difficult to predict; however, this very same complexity enables multiple possible strategies for engineering promoter strength. Here, we studied promoter architecture in the oleaginous yeast, Yarrowia lipolytica. While recent studies have focused on upstream activating sequences, we systematically examined various components common in fungal promoters. Here, we examine several promoter components including upstream activating sequences, proximal promoter sequences, core promoters, and the TATA box in autonomously replicating expression plasmids and integrated into the genome. Our findings show that promoter strength can be fine-tuned through the engineering of the TATA box sequence, core promoter, and upstream activating sequences. Additionally, we identified a previously unreported oleic acid responsive transcription enhancement in the XPR2 upstream activating sequences, which illustrates the complexity of fungal promoters. The promoters engineered here provide new genetic tools for metabolic engineering in Y. lipolytica and provide promoter engineering strategies that may be useful in engineering other non-model fungal systems.

78 FR 61388 - TA-W-82,705, the Boeing Company Boeing Commercial Aircraft, (BCA) Including On-Site Leased...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-03

..., (BCA) Including On-Site Leased Workers From Adecco, USA, Inc., Cascade Engineering, CDI Corporation...., Cascade Engineering, CDI Corporation, Chipton Ross, Inc., Comforce Corporation, Computer Staffing Services...

Our Commitment to Reliable Health and Medical Information

MedlinePlus

... 000 visitors world-wide per day. HONcode Toolbar: search engine and checker of the certification status Automatically checks ... HONcode status when browsing health web sites. The search engine indexes only HONcode-certified sites. HONcodeHunt currently includes ...

solar thermal power systems advanced solar thermal technology project, advanced subsystems development

NASA Technical Reports Server (NTRS)

1979-01-01

The preliminary design for a prototype small (20 kWe) solar thermal electric generating unit was completed, consisting of several subsystems. The concentrator and the receiver collect solar energy and a thermal buffer storage with a transport system is used to provide a partially smoothed heat input to the Stirling engine. A fossil-fuel combustor is included in the receiver designs to permit operation with partial or no solar insolation (hybrid). The engine converts the heat input into mechanical action that powers a generator. To obtain electric power on a large scale, multiple solar modules will be required to operate in parallel. The small solar electric power plant used as a baseline design will provide electricity at remote sites and small communities.

[Engineering of a System for the Production of Mutant Human Alpha-Fetoprotein in the Methylotrophic Yeast Pichia pastoris].

PubMed

Morozkina, E V; Vavilova, E A; Zatsepin, S S; Klyachko, E V; Yagudin, T A; Chulkin, A M; Dudich, I V; Semenkova, L N; Churilova, I V; Benevolenskii, S V

2016-01-01

A system for the production of mutant recombinant human alpha-fetoprotein (rhAFPO) lacking the glycosylation site has been engineered in the yeast Pichia pastoris. A strain of the methylotrophic yeast Pichia pastoris GS 115/pPICZ?A/rhAFP0, which produces unglycosylated rhAFPO and secretes it to the culture medium, has been constructed. Optimization and scale-up of the fermentation technology have resulted in an increase in the rhAFP0 yield to 20 mg/L. A scheme of isolation and purification of biologically active rhAFP0 has been developed. The synthesized protein has the antitumor activity, which is analogous to the activity of natural human embryonic alpha-fetoprotein.

Simulate different environments TDLAS On the analysis of the test signal strength

NASA Astrophysics Data System (ADS)

Li, Xin; Zhou, Tao; Jia, Xiaodong

2014-12-01

TDLAS system is the use of the wavelength tuning characteristics of the laser diode, for detecting the absorption spectrum of the gas absorption line. Detecting the gas space, temperature, pressure and flow rate and concentration. The use of laboratory techniques TDLAS gas detection, experimental simulation engine combustion water vapor and smoke. using an optical lens system receives the signal acquisition and signal interference test analysis. Analog water vapor and smoke in two different environments in the sample pool interference. In both experiments environmental interference gas absorption in the optical signal acquisition, signal amplitude variation analysis, and records related to the signal data. In order to study site conditions in the engine combustion process for signal acquisition provides an ideal experimental data .

Genome-wide target profiling of piggyBac and Tol2 in HEK 293: pros and cons for gene discovery and gene therapy

PubMed Central

2011-01-01

Background DNA transposons have emerged as indispensible tools for manipulating vertebrate genomes with applications ranging from insertional mutagenesis and transgenesis to gene therapy. To fully explore the potential of two highly active DNA transposons, piggyBac and Tol2, as mammalian genetic tools, we have conducted a side-by-side comparison of the two transposon systems in the same setting to evaluate their advantages and disadvantages for use in gene therapy and gene discovery. Results We have observed that (1) the Tol2 transposase (but not piggyBac) is highly sensitive to molecular engineering; (2) the piggyBac donor with only the 40 bp 3'-and 67 bp 5'-terminal repeat domain is sufficient for effective transposition; and (3) a small amount of piggyBac transposases results in robust transposition suggesting the piggyBac transpospase is highly active. Performing genome-wide target profiling on data sets obtained by retrieving chromosomal targeting sequences from individual clones, we have identified several piggyBac and Tol2 hotspots and observed that (4) piggyBac and Tol2 display a clear difference in targeting preferences in the human genome. Finally, we have observed that (5) only sites with a particular sequence context can be targeted by either piggyBac or Tol2. Conclusions The non-overlapping targeting preference of piggyBac and Tol2 makes them complementary research tools for manipulating mammalian genomes. PiggyBac is the most promising transposon-based vector system for achieving site-specific targeting of therapeutic genes due to the flexibility of its transposase for being molecularly engineered. Insights from this study will provide a basis for engineering piggyBac transposases to achieve site-specific therapeutic gene targeting. PMID:21447194

Liquid rocket booster integration study. Volume 3: Study products. Part 2: Sections 8-19

NASA Technical Reports Server (NTRS)

1988-01-01

The impacts of introducing liquid rocket booster engines (LRB) into the Space Transportation System (STS)/Kennedy Space Center (KSC) launch environment are identified and evaluated. Proposed ground systems configurations are presented along with a launch site requirements summary. Prelaunch processing scenarios are described and the required facility modifications and new facility requirements are analyzed. Flight vehicle design recommendations to enhance launch processing are discussed. Processing approaches to integrate LRB with existing STS launch operations are evaluated. The key features and significance of launch site transition to a new STS configuration in parallel with ongoing launch activities are enumerated. This volume is part two of the study products section of the five volume series.

Liquid rocket booster integration study. Volume 3, part 1: Study products

NASA Technical Reports Server (NTRS)

1988-01-01

The impacts of introducing liquid rocket booster engines (LRB) into the Space Transportation System (STS)/Kennedy Space Center (KSC) launch environment are identified and evaluated. Proposed ground systems configurations are presented along with a launch site requirements summary. Prelaunch processing scenarios are described and the required facility modifications and new facility requirements are analyzed. Flight vehicle design recommendations to enhance launch processing are discussed. Processing approaches to integrate LRB with existing STS launch operations are evaluated. The key features and significance of launch site transition to a new STS configuration in parallel with ongoing launch activities are enumerated. This volume is part one of the study products section of the five volume series.

A New Blondin System for Surveying and Photogrammetry

PubMed Central

Cuesta, Federico; Lopez-Rodriguez, Francisco M.; Esteban, Antonio

2013-01-01

The main objective of the system presented in this paper is to provide surveyors and engineers with a new photogrammetry device that can be easily integrated with surveying total stations and a global navigation satellite system (GNSS) infrastructure at a construction site, taking advantage of their accuracy and overcoming limitations of aerial vehicles with respect to weight, autonomy and skilled operator requirements in aerial photogrammetry. The system moves between two mounting points, in a blondin ropeway configuration, at the construction site, taking pictures and recording the data of the position and the orientation along the cable path. A cascaded extended Kalman filter is used to integrate measurements from the on-board inertial measurement unit (IMU), a GPS and a GNSS. Experimental results taken in a construction site show the system performance, including the validation of the position estimation, with a robotic surveying total station, or the creation of a digital surface model (DSM), using the emergent structure from motion (SfM) techniques and open software. The georeferencing of the DSM is performed based on estimated camera position or using ground control points (GCPs).

Evaluation of engineering properties for the use of leached brown coal ash in soil covers.

PubMed

Mudd, Gavin M; Chakrabarti, Srijib; Kodikara, Jayantha

2007-01-31

The need to engineer cover systems for the successful rehabilitation or remediation of a wide variety of solid wastes is increasing. Some common applications include landfills, hazardous waste repositories, or mine tailings dams and waste rock/overburden dumps. The brown coal industry of the Latrobe Valley region of Victoria, Australia, produces significant quantities of coal ash and overburden annually. There are some site-specific acid mine drainage (AMD) issues associated with overburden material. This needs to be addressed both during the operational phase of a project and during rehabilitation. An innovative approach was taken to investigate the potential to use leached brown coal ash in engineered soil covers on this overburden dump. The basis for this is two-fold: first, the ash has favourable physical characteristics for use in cover systems (such as high storage capacity/porosity, moderately low permeability, and an ability to act as a capillary break layer generating minimal leachate or seepage); and second, the leachate from the ash is mildly alkaline (which can help to mitigate and reduce the risk of AMD). This paper will review the engineering issues involved in using leached brown coal ash in designing soil covers for potentially acid-forming overburden dumps. It presents the results of laboratory work investigating the technical feasibility of using leached brown coal ash in engineered solid waste cover systems.

Human-factors engineering control-room design review/audit: Waterford 3 SES Generating Station, Louisiana Power and Light Company

DOE Office of Scientific and Technical Information (OSTI.GOV)

Savage, J.W.

1983-03-10

A human factors engineering design review/audit of the Waterford-3 control room was performed at the site on May 10 through May 13, 1982. The report was prepared on the basis of the HFEB's review of the applicant's Preliminary Human Engineering Discrepancy (PHED) report and the human factors engineering design review performed at the site. This design review was carried out by a team from the Human Factors Engineering Branch, Division of Human Factors Safety. The review team was assisted by consultants from Lawrence Livermore National Laboratory (University of California), Livermore, California.

Evaluating Groundwater-Surface Water Exchange With A New Point Measurement Device

NASA Astrophysics Data System (ADS)

Cremeans, M.; Devlin, J. F.; McKnight, U. S.; Bjerg, P. L.; Nairn, R.

2017-12-01

Estimating exchange at the groundwater-surface water interface (GWSWI) could be crucial to designing effective remediation measures. The StreamBed Point Velocity Probe (SBPVP), a new point measurement device, measures in situ groundwater velocities at the GWSWI without reliance on estimations of hydraulic conductivity, porosity, or gradient information. The SBPVP has been applied to natural and engineered interfaces at contaminated sites, a stream and vertical flow bioreactor, respectively. Velocity data ( 18 cm/day to 2600 cm/day in the stream, and 54 cm/day to 161 cm/day in the bioreactor) were used to determine water and solute fluxes (as well as potential contaminant attenuation rates) at these sites. Analysis of the spatial distribution of velocity values in a streambed illustrated the extremely heterogeneous nature of that environment, while the engineered system was found to be relatively homogeneous by comparison. Combining SBPVP velocity data with geochemical data supports the calculation of mass discharges and mass removal rates. The wide range of exchange rate variability (within and between these sites) suggests that detailed characterization of the GWSWI interface is useful information for remediation in both cases.

Structure-Guided Engineering of Molinate Hydrolase for the Degradation of Thiocarbamate Pesticides

PubMed Central

Paiva, Ana M.; Ferreira-da-Silva, Frederico; Matias, Pedro M.; Nunes, Olga C.; Gales, Luís

2015-01-01

Molinate is a recalcitrant thiocarbamate used to control grass weeds in rice fields. The recently described molinate hydrolase, from Gulosibacter molinativorax ON4T, plays a key role in the only known molinate degradation pathway ending in the formation of innocuous compounds. Here we report the crystal structure of recombinant molinate hydrolase at 2.27 Å. The structure reveals a homotetramer with a single mononuclear metal-dependent active site per monomer. The active site architecture shows similarities with other amidohydrolases and enables us to propose a general acid-base catalysis mechanism for molinate hydrolysis. Molinate hydrolase is unable to degrade bulkier thiocarbamate pesticides such as thiobencarb which is used mostly in rice crops. Using a structural-based approach, we were able to generate a mutant (Arg187Ala) that efficiently degrades thiobencarb. The engineered enzyme is suitable for the development of a broader thiocarbamate bioremediation system. PMID:25905461

OTEC platform configuration and integration study. Volume I. Systems engineering and integration. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1978-04-01

The economic success of an Ocean Thermal Energy Conversion (OTEC) system is highly dependent on a platform which provides adequate support for the power system, accommodates reliably the cold water pipe, and is most cost effective. The results of a study conducted for the Department of Energy to assess six generic types of platforms to determine the most satisfactory platform for severl potential sites are presented. The six platform configurations are ship, circular barge, semi-submersible, Tuned Sphere, submersible, and spar. These represent directional and symmetric types of platforms which operate on the surface, at the interface, and submerged. The fivemore » sites for this study were primarily New Orleans, Keahole Point (Hawaii), Brazil, and secondarily Key West and Puerto Rico. Electrical transmission of energy by submarine cable is the planned form of energy transmission for all sites except Brazil, where chemical conversion is to be the method of transmission. This study is devoted to the platform (or ocean systems) of the OTEC plant which is chiefly comprised of the hull and structure, the seawater system, the position control system, and miscellaneous support/assembly systems. The principal elements in the work breakdown structure for the commercial plants are presented. The assessment of the six platform configurations was conducted utilizing a baseline plan (100-MW(e) (Net)) and site (New Orleans) with variations from the baseline to cover the range of interested platforms and sites.« less

Study of launch site processing and facilities for future launch vehicles

NASA Astrophysics Data System (ADS)

Shaffer, Rex

1995-03-01

The purpose of this research is to provide innovative and creative approaches to assess the impact to the Kennedy Space Center and other launch sites for a range of candidate manned and unmanned space transportation systems. The general scope of the research includes the engineering activities, analyses, and evaluations defined in the four tasks below: (1) development of innovative approaches and computer aided tools; (2) operations analyses of launch vehicle concepts and designs; (3) assessment of ground operations impacts; and (4) development of methodologies to identify promising technologies.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holloway, Lawrence E.; Qu, Zhihua; Mohr-Schroeder, Margaret J.

In this study, we consider collaborative power systems education through the FEEDER consortium. To increase students' access to power engineering educational content, the consortium of seven universities was formed. A framework is presented to characterize different collaborative education activities among the universities. Three of these approaches of collaborative educational activities are presented and discussed. These include 1) cross-institutional blended courses ("MS-MD''); 2) cross-institutional distance courses ("SS-MD''); and 3) single-site special experiential courses and concentrated on-site programs available to students across consortium institutions ("MS-SD''). As a result, this paper presents the advantages and disadvantages of each approach.

Study of launch site processing and facilities for future launch vehicles

NASA Technical Reports Server (NTRS)

Shaffer, Rex

1995-01-01

The purpose of this research is to provide innovative and creative approaches to assess the impact to the Kennedy Space Center and other launch sites for a range of candidate manned and unmanned space transportation systems. The general scope of the research includes the engineering activities, analyses, and evaluations defined in the four tasks below: (1) development of innovative approaches and computer aided tools; (2) operations analyses of launch vehicle concepts and designs; (3) assessment of ground operations impacts; and (4) development of methodologies to identify promising technologies.

Collaborative-Large scale Engineering Assessment Networks for Environmental Research: The Overview

NASA Astrophysics Data System (ADS)

Moo-Young, H.

2004-05-01

A networked infrastructure for engineering solutions and policy alternatives is necessary to assess, manage, and protect complex, anthropogenic ally stressed environmental resources effectively. Reductionist and discrete disciplinary methodologies are no longer adequate to evaluate and model complex environmental systems and anthropogenic stresses. While the reductonist approach provides important information regarding individual mechanisms, it cannot provide complete information about how multiple processes are related. Therefore, it is not possible to make accurate predictions about system responses to engineering interventions and the effectiveness of policy options. For example, experts cannot agree on best management strategies for contaminated sediments in riverine and estuarine systems. This is due, in part to the fact that existing models do not accurately capture integrated system dynamics. In addition, infrastructure is not available for investigators to exchange and archive data, to collaborate on new investigative methods, and to synthesize these results to develop engineering solutions and policy alternatives. Our vision for the future is to create a network comprising field facilities and a collaboration of engineers, scientists, policy makers, and community groups. This will allow integration across disciplines, across different temporal and spatial scales, surface and subsurface geographies, and air sheds and watersheds. Benefits include fast response to changes in system health, real-time decision making, and continuous data collection that can be used to anticipate future problems, and to develop sound engineering solutions and management decisions. CLEANER encompasses four general aspects: 1) A Network of environmental field facilities instrumented for the acquisition and analysis of environmental data; 2) A Virtual Repository of Data and information technology for engineering modeling, analysis and visualization of data, i.e. an environmental cyber-infrastructure; 3) A Mechanism for multidisciplinary research and education activities designed to exploit the output of the instrumented sites and networked information technology, to formulate engineering and policy options directed toward the protection, remediation, and restoration of stressed environments and sustainability of environmental resources; and 4) A Collaboration among engineers, natural and social scientists, educators, policy makers, industry, non-governmental organizations, the public, and other stakeholders.

Evaluation of hybrid inverters for strategic environmental research and development program applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginn, J.W.

1995-11-01

The photovoltaic systems test facility at Sandia National Laboratories is evaluating the performance of large hybrid power-processing centers (PPC`s). The primary customer for this work has been the Strategic Environmental Research and Development Program (SERDP) of the Department of Defense. One of the goals of SERDP is to develop power-processing hardware to be used in photovoltaic-hybrid power systems at remote military installations. Power for these installations is presently provided by engine-generators. Currently, hardware for twelve such sites is in various stages of procurement. The subject of this talk is testing of the PPC for the first SERDP system, a 300-kWmore » unit for Superior Valley, a US Navy site at China Lake, California.« less

Hanford Environmental Information System (HEIS) Operator`s Manual. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schreck, R.I.

1991-10-01

The Hanford Environmental Information System (HEIS) is a consolidated set of automated resources that effectively manage the data gathered during environmental monitoring and restoration of the Hanford Site. The HEIS includes an integrated database that provides consistent and current data to all users and promotes sharing of data by the entire user community. This manual describes the facilities available to the operational user who is responsible for data entry, processing, scheduling, reporting, and quality assurance. A companion manual, the HEIS User`s Manual, describes the facilities available-to the scientist, engineer, or manager who uses the system for environmental monitoring, assessment, andmore » restoration planning; and to the regulator who is responsible for reviewing Hanford Site operations against regulatory requirements and guidelines.« less

Geological considerations in hazardouswaste disposal

NASA Astrophysics Data System (ADS)

Cartwright, K.; Gilkeson, R. H.; Johnson, T. M.

1981-12-01

Present regulations assume that long-term isolation of hazardous wastes — including toxic chemical, biological, radioactive, flammable and explosive wastes — may be effected by disposal in landfills that have liners of very low hydraulic conductivity. In reality, total isolation of wastes in humid areas is not possible; some migration of leachate from wastes buried in the gound will always occur. Regulations should provide performance standards applicable on a site-by-site basis rather than rigid criteria for site selection and design. The performance standards should take into account several factors: (1) the categories, segregation, degradation and toxicity of the wastes; (2) the site hydrogeology, which governs the direction and rate of contaminant transport; (3) the attenuation of contaminants by geochemical interactions with geologic materials; and (4) the release rate of unattenuated pollutants to surface or groundwater. An adequate monitoring system is essential. The system should both test the extent to which the operation of the site meets performance standards and provide sufficient warning of pollution problems to allow implementation of remedial measures. In recent years there has been a trend away from numerous, small disposal sites toward fewer and larger sites. The size of a disposal site should be based on the attenuation capacity of the geologic material, which has a finite, though generally not well-defined, limit. For slowly degradable wastes, engineered sites with leachate-collection systems appear to be only a temporary solution since the leachate collected will also require final disposal.

Geological considerations in hazardouswaste disposal

USGS Publications Warehouse

Cartwright, K.; Gilkeson, R.H.; Johnson, T.M.

1981-01-01

Present regulations assume that long-term isolation of hazardous wastes - including toxic chemical, biological, radioactive, flammable and explosive wastes - may be effected by disposal in landfills that have liners of very low hydraulic conductivity. In reality, total isolation of wastes in humid areas is not possible; some migration of leachate from wastes buried in the gound will always occur. Regulations should provide performance standards applicable on a site-by-site basis rather than rigid criteria for site selection and design. The performance standards should take into account several factors: (1) the categories, segregation, degradation and toxicity of the wastes; (2) the site hydrogeology, which governs the direction and rate of contaminant transport; (3) the attenuation of contaminants by geochemical interactions with geologic materials; and (4) the release rate of unattenuated pollutants to surface or groundwater. An adequate monitoring system is essential. The system should both test the extent to which the operation of the site meets performance standards and provide sufficient warning of pollution problems to allow implementation of remedial measures. In recent years there has been a trend away from numerous, small disposal sites toward fewer and larger sites. The size of a disposal site should be based on the attenuation capacity of the geologic material, which has a finite, though generally not well-defined, limit. For slowly degradable wastes, engineered sites with leachate-collection systems appear to be only a temporary solution since the leachate collected will also require final disposal. ?? 1981.

Quality of anaesthesia-related information accessed via Internet searches.

PubMed

Caron, S; Berton, J; Beydon, L

2007-08-01

We conducted a study to examine the quality and stability of information available from the Internet on four anaesthesia-related topics. In January 2006, we searched using four key words (porphyria, scleroderma, transfusion risk, and epidural analgesia risk) with five search engines (Google, HotBot, AltaVista, Excite, and Yahoo). We used a published scoring system (NetScoring) to evaluate the first 15 sites identified by each of these 20 searches. We also used a simple four-point scale to assess the first 100 sites in the Google search on one of our four topics ('epidural analgesia risk'). In November 2006, we conducted a second evaluation, using three search engines (Google, AltaVista, and Yahoo) with 14 synonyms for 'epidural analgesia risk'. The five search engines performed similarly. NetScoring scores were lower for transfusion risk (P < 0.001). One or more high-quality sites was identified consistently among the first 15 sites in each search. Quality scored using the simple scale correlated closely with medical content and design by NetScoring and with the number of references (P < 0.05). Synonyms of 'epidural analgesia risk' yielded similar results. The quality of accessed information improved somewhat over the 11 month period with Yahoo and AltaVista, but declined with Google. The Internet is a valuable tool for obtaining medical information, but the quality of websites varies between different topics. A simple rating scale may facilitate the quality scoring on individual websites. Differences in precise search terms used for a given topic did not appear to affect the quality of the information obtained.

SWS: accessing SRS sites contents through Web Services.

PubMed

Romano, Paolo; Marra, Domenico

2008-03-26

Web Services and Workflow Management Systems can support creation and deployment of network systems, able to automate data analysis and retrieval processes in biomedical research. Web Services have been implemented at bioinformatics centres and workflow systems have been proposed for biological data analysis. New databanks are often developed by taking into account these technologies, but many existing databases do not allow a programmatic access. Only a fraction of available databanks can thus be queried through programmatic interfaces. SRS is a well know indexing and search engine for biomedical databanks offering public access to many databanks and analysis tools. Unfortunately, these data are not easily and efficiently accessible through Web Services. We have developed 'SRS by WS' (SWS), a tool that makes information available in SRS sites accessible through Web Services. Information on known sites is maintained in a database, srsdb. SWS consists in a suite of WS that can query both srsdb, for information on sites and databases, and SRS sites. SWS returns results in a text-only format and can be accessed through a WSDL compliant client. SWS enables interoperability between workflow systems and SRS implementations, by also managing access to alternative sites, in order to cope with network and maintenance problems, and selecting the most up-to-date among available systems. Development and implementation of Web Services, allowing to make a programmatic access to an exhaustive set of biomedical databases can significantly improve automation of in-silico analysis. SWS supports this activity by making biological databanks that are managed in public SRS sites available through a programmatic interface.

Plots, Calculations and Graphics Tools (PCG2). Software Transfer Request Presentation

NASA Technical Reports Server (NTRS)

Richardson, Marilou R.

2010-01-01

This slide presentation reviews the development of the Plots, Calculations and Graphics Tools (PCG2) system. PCG2 is an easy to use tool that provides a single user interface to view data in a pictorial, tabular or graphical format. It allows the user to view the same display and data in the Control Room, engineering office area, or remote sites. PCG2 supports extensive and regular engineering needs that are both planned and unplanned and it supports the ability to compare, contrast and perform ad hoc data mining over the entire domain of a program's test data.

Construction of web-based nutrition education contents and searching engine for usage of healthy menu of children

PubMed Central

Lee, Tae-Kyong; Chung, Hea-Jung; Park, Hye-Kyung; Lee, Eun-Ju; Nam, Hye-Seon; Jung, Soon-Im; Cho, Jee-Ye; Lee, Jin-Hee; Kim, Gon; Kim, Min-Chan

2008-01-01

A diet habit, which is developed in childhood, lasts for a life time. In this sense, nutrition education and early exposure to healthy menus in childhood is important. Children these days have easy access to the internet. Thus, a web-based nutrition education program for children is an effective tool for nutrition education of children. This site provides the material of the nutrition education for children with characters which are personified nutrients. The 151 menus are stored in the site together with video script of the cooking process. The menus are classified by the criteria based on age, menu type and the ethnic origin of the menu. The site provides a search function. There are three kinds of search conditions which are key words, menu type and "between" expression of nutrients such as calorie and other nutrients. The site is developed with the operating system Windows 2003 Server, the web server ZEUS 5, development language JSP, and database management system Oracle 10 g. PMID:20126375

Integrated Logistics Support approach: concept for the new big projects: E-ELT, SKA, CTA

NASA Astrophysics Data System (ADS)

Marchiori, G.; Rampini, F.; Formentin, F.

2014-08-01

The Integrated Logistic Support is a process supporting strategies and optimizing activities for a correct project management and system engineering development. From the design & engineering of complex technical systems, to the erection on site, acceptance and after-sales service, EIE GROUP covers all aspects of the Integrated Logistics Support (ILS) process that includes: costing process centered around the life cycle cost and Level of Repair Analyses; engineering process which influences the design via means of reliability, modularization, etc.; technical publishing process based on international specifications; ordering administration process for supply support. Through the ILS, EIE GROUP plans and directs the identification and development of logistics support and system requirements for its products, with the goal of creating systems that last longer and require less support, thereby reducing costs and increasing return on investments. ILS therefore, addresses these aspects of supportability not only during acquisition, but also throughout the operational life cycle of the system. The impact of the ILS is often measured in terms of metrics such as reliability, availability, maintainability and testability (RAMT), and System Safety (RAMS). Example of the criteria and approach adopted by EIE GROUP during the design, manufacturing and test of the ALMA European Antennas and during the design phase of the E-ELT telescope and Dome are presented.

Cavity detection and delineation research. Part 1: Microgravimetric and magnetic surveys: Medford Cave Site, Florida

NASA Astrophysics Data System (ADS)

Butler, D. K.

1982-03-01

This report reviews the scope of a research effort initiated in 1974 at the U.S. Army Engineer Waterways Experiment Station with the objectives of (a) assessing the state of the art in geophysical cavity detection and delineation methodology and (b) developing new methods and improving or adapting old methods for application to cavity detection and delineation. Two field test sites were selected: (a) the Medford Cave site with a relatively shallow (10- to 50-ft-deep) air-filled cavity system and (b) the Manatee Springs site with a deeper (approximately 100-ft-deep) water-filled cavity system. Results of field studies at the Medford Cave site are presented in this report: (a) the site geology, (b) the site topographic survey, (c) the site drilling program (boreholes for geophysical tests, for determination of a detailed geological cross section, and for verification of geophysical anomalies), (d) details of magnetic and microgravimetric surveys, and (e) correlation of geophysical results with known site geology. Qualitative interpretation guidelines using complementary geophysical techniques for site investigations in karst regions are presented. Including the results of electrical resistivity surveys conducted at the Medford Cave site, the qualitative guidelines are applied to four profile lines, and drilling locations are indicated on the profile plots of gravity, magnetic, and electrical resistivity data. Borehole logs are then presented for comparison with the predictions of the qualitative interpretation guidelines.

Essie: A Concept-based Search Engine for Structured Biomedical Text

PubMed Central

Ide, Nicholas C.; Loane, Russell F.; Demner-Fushman, Dina

2007-01-01

This article describes the algorithms implemented in the Essie search engine that is currently serving several Web sites at the National Library of Medicine. Essie is a phrase-based search engine with term and concept query expansion and probabilistic relevancy ranking. Essie’s design is motivated by an observation that query terms are often conceptually related to terms in a document, without actually occurring in the document text. Essie’s performance was evaluated using data and standard evaluation methods from the 2003 and 2006 Text REtrieval Conference (TREC) Genomics track. Essie was the best-performing search engine in the 2003 TREC Genomics track and achieved results comparable to those of the highest-ranking systems on the 2006 TREC Genomics track task. Essie shows that a judicious combination of exploiting document structure, phrase searching, and concept based query expansion is a useful approach for information retrieval in the biomedical domain. PMID:17329729

Full power level development of the Space Shuttle main engine

NASA Technical Reports Server (NTRS)

Johnson, J. R.; Colbo, H. I.

1982-01-01

Development of the Space Shuttle main engine for nominal operation at full power level (109 percent rated power) is continuing in parallel with the successful flight testing of the Space Transportation System. Verification of changes made to the rated power level configuration currently being flown on the Orbiter Columbia is in progress and the certification testing of the full power level configuration has begun. The certification test plan includes the accumulation of 10,000 seconds on each of two engines by early 1983. Certification testing includes the simulation of nominal mission duty cycles as well as the two abort thrust profiles: abort to orbit and return to launch site. Several of the certification tests are conducted at 111 percent power to demonstrate additional safety margins. In addition to the flight test and development program results, future plans for life demonstration and engine uprating will be discussed.

Design and Empirical Evaluation of Search Software for Legal Professionals on the WWW.

ERIC Educational Resources Information Center

Dempsey, Bert J.; Vreeland, Robert C.; Sumner, Robert G., Jr.; Yang, Kiduk

2000-01-01

Discussion of effective search aids for legal researchers on the World Wide Web focuses on the design and evaluation of two software systems developed to explore models for browsing and searching across a user-selected set of Web sites. Describes crawler-enhanced search engines, filters, distributed full-text searching, and natural language…

33 CFR 336.1 - Discharges of dredged or fill material into waters of the U.S.

Code of Federal Regulations, 2014 CFR

2014-07-01

... alone would prohibit the designation of a proposed discharge site, the economic impact on navigation and... interest the district engineer should re-examine the project viability to ensure that continued maintenance... navigation system is essential to the economic well-being and national defense of the country. The district...

33 CFR 336.1 - Discharges of dredged or fill material into waters of the U.S.

Code of Federal Regulations, 2010 CFR

2010-07-01

... alone would prohibit the designation of a proposed discharge site, the economic impact on navigation and... interest the district engineer should re-examine the project viability to ensure that continued maintenance... navigation system is essential to the economic well-being and national defense of the country. The district...

33 CFR 336.1 - Discharges of dredged or fill material into waters of the U.S.

Code of Federal Regulations, 2012 CFR

2012-07-01

... alone would prohibit the designation of a proposed discharge site, the economic impact on navigation and... interest the district engineer should re-examine the project viability to ensure that continued maintenance... navigation system is essential to the economic well-being and national defense of the country. The district...

33 CFR 336.1 - Discharges of dredged or fill material into waters of the U.S.

Code of Federal Regulations, 2011 CFR

2011-07-01

... alone would prohibit the designation of a proposed discharge site, the economic impact on navigation and... interest the district engineer should re-examine the project viability to ensure that continued maintenance... navigation system is essential to the economic well-being and national defense of the country. The district...

33 CFR 336.1 - Discharges of dredged or fill material into waters of the U.S.

Code of Federal Regulations, 2013 CFR

2013-07-01

... alone would prohibit the designation of a proposed discharge site, the economic impact on navigation and... interest the district engineer should re-examine the project viability to ensure that continued maintenance... navigation system is essential to the economic well-being and national defense of the country. The district...

Mechanical stimulation improves tissue-engineered human skeletal muscle

NASA Technical Reports Server (NTRS)

Powell, Courtney A.; Smiley, Beth L.; Mills, John; Vandenburgh, Herman H.

2002-01-01

Human bioartificial muscles (HBAMs) are tissue engineered by suspending muscle cells in collagen/MATRIGEL, casting in a silicone mold containing end attachment sites, and allowing the cells to differentiate for 8 to 16 days. The resulting HBAMs are representative of skeletal muscle in that they contain parallel arrays of postmitotic myofibers; however, they differ in many other morphological characteristics. To engineer improved HBAMs, i.e., more in vivo-like, we developed Mechanical Cell Stimulator (MCS) hardware to apply in vivo-like forces directly to the engineered tissue. A sensitive force transducer attached to the HBAM measured real-time, internally generated, as well as externally applied, forces. The muscle cells generated increasing internal forces during formation which were inhibitable with a cytoskeleton depolymerizer. Repetitive stretch/relaxation for 8 days increased the HBAM elasticity two- to threefold, mean myofiber diameter 12%, and myofiber area percent 40%. This system allows engineering of improved skeletal muscle analogs as well as a nondestructive method to determine passive force and viscoelastic properties of the resulting tissue.

Description of piezometers installed in the middle Rio Grande basin area, 1997-99, central New Mexico

USGS Publications Warehouse

Bartolino, J.R.; Rankin, D.R.

2000-01-01

Since 1993, the Santa Fe Group aquifer system in the Middle Rio Grande Basin, and particularly in the Albuquerque area, has been the focus of studies to further define the extent of the most productive parts of the aquifer and to gain a better understanding of how ground- water levels are changing over time. The U.S. Geological Survey, in cooperation with the New Mexico Office of the State Engineer, installed nine piezometers during 1998-99 at five sites in and near the margin of the Middle Rio Grande Basin in central New Mexico. In addition, the New Mexico Office of the State Engineer installed another nine piezometers at three sites during 1997. These piezometers allow for collection of ground-water-level data in areas for which little information is available. Most of the piezometers were constructed of 2.5-inch-diameter flush-joint polyvinyl chloride (PVC) schedule 80 casing with 10-foot stainless steel screens; the shallow piezometer at the Tome site has a 40-foot screen, and the single piezometers at the Dome Road and Phoenix Road sites have steel casing with welded joints and a 10- and a 20-foot screen, respectively. Steel casing with a locking lid covers the uppermost 2 feet of the piezometer casing. Drillers' logs and petrophysical logs were collected from the deepest borehole at each site.

Measurement Sets and Sites Commonly Used for High Spatial Resolution Image Product Characterization

NASA Technical Reports Server (NTRS)

Pagnutti, Mary

2006-01-01

Scientists within NASA's Applied Sciences Directorate have developed a well-characterized remote sensing Verification & Validation (V&V) site at the John C. Stennis Space Center (SSC). This site has enabled the in-flight characterization of satellite high spatial resolution remote sensing system products form Space Imaging IKONOS, Digital Globe QuickBird, and ORBIMAGE OrbView, as well as advanced multispectral airborne digital camera products. SSC utilizes engineered geodetic targets, edge targets, radiometric tarps, atmospheric monitoring equipment and their Instrument Validation Laboratory to characterize high spatial resolution remote sensing data products. This presentation describes the SSC characterization capabilities and techniques in the visible through near infrared spectrum and examples of calibration results.

Analog earthquakes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hofmann, R.B.

1995-09-01

Analogs are used to understand complex or poorly understood phenomena for which little data may be available at the actual repository site. Earthquakes are complex phenomena, and they can have a large number of effects on the natural system, as well as on engineered structures. Instrumental data close to the source of large earthquakes are rarely obtained. The rare events for which measurements are available may be used, with modfications, as analogs for potential large earthquakes at sites where no earthquake data are available. In the following, several examples of nuclear reactor and liquified natural gas facility siting are discussed.more » A potential use of analog earthquakes is proposed for a high-level nuclear waste (HLW) repository.« less

Direct Quantification of Methane Emissions Across the Supply Chain: Identification of Mitigation Targets

NASA Astrophysics Data System (ADS)

Darzi, M.; Johnson, D.; Heltzel, R.; Clark, N.

2017-12-01

Researchers at West Virginia University's Center for Alternative Fuels, Engines, and Emissions have recently participated in a variety of studies targeted at direction quantification of methane emissions from across the natural gas supply chain. These studies included assessing methane emissions from heavy-duty vehicles and their fuel stations, active unconventional well sites - during both development and production, natural gas compression and storage facilities, natural gas engines - both large and small, two- and four-stroke, and low-throughput equipment associated with coal bed methane wells. Engine emissions were sampled using conventional instruments such as Fourier transform infrared spectrometers and heated flame ionization detection analyzers. However, to accurately quantify a wide range of other sources beyond the tailpipe (both leaks and losses), a full flow sampling system was developed, which included an integrated cavity-enhanced absorption spectrometer. Through these direct quantification efforts and analysis major sources of methane emissions were identified. Technological solutions and best practices exist or could be developed to reduce methane emissions by focusing on the "lowest-hanging fruit." For example, engine crankcases from across the supply chain should employ vent mitigation systems to reduce methane and other emissions. An overview of the direct quantification system and various campaign measurements results will be presented along with the identification of other targets for additional mitigation.

Transgene manipulation in zebrafish by using recombinases.

PubMed

Dong, Jie; Stuart, Gary W

2004-01-01

Although much remains to be done, our results to date suggest that efficient and precise genome engineering in zebrafish will be possible in the future by using Cre recombinase and SB transposase in combination with their respective target sites. In this study, we provide the first evidence that Cre recombinase can mediate effective site-specific deletion of transgenes in zebrafish. We found that the efficiency of target site utilization could approach 100%, independent of whether the target site was provided transiently by injection or stably within an integrated transgene. Microinjection of Cre mRNA appeared to be slightly more effective for this purpose than microinjection of Cre-expressing plasmid DNA. Our work has not yet progressed to the point where SB-mediated mobilization of our transgene constructs would be observed. However, a recent report has demonstrated that SB can enhance transgenesis rates sixfold over conventional methods by efficiently mediating multiple single-copy insertion of transgenes into the zebrafish genome (Davidson et al., 2003). Therefore, it seems likely that a combined system should eventually allow both SB-mediated transgene mobilization and Cre-mediated transgene modification. Our goal is to validate methods for the precise reengineering of the zebrafish genome by using a combination of Cre-loxP and SB transposon systems. These methods can be used to delete, replace, or mobilize large pieces of DNA or to modify the genome only when and where required by the investigator. For example, it should be possible to deliver particular RNAi genes to well-expressed chromosomal loci and then exchange them easily with alternative RNAi genes for the specific suppression of alternative targets. As a nonviral vector for gene therapy, the transposon component allows for the possibility of highly efficient integration, whereas the Cre-loxP component can target the integration and/or exchange of foreign DNA into specific sites within the genome. The specificity and efficiency of this system also make it ideal for applications in which precise genome modifications are required (e.g., stock improvement). Future work should establish whether alternative recombination systems (e.g., phiC31 integrase) can improve the utility of this system. After the fish system is fully established, it would be interesting to explore its application to genome engineering in other organisms.

Electrical engineering support of telemetered traffic monitoring sites : final report, March 2009.

DOT National Transportation Integrated Search

2009-03-01

"The aim of this project was to provide electrical engineering support for the telemetered traffic monitoring sites (TTMS) operated by the Statistics Office of the Florida Department of Transportation. This project was a companion to project BD-543-1...

An Introduction to the Cost of Engineering and Institutional Controls at Brownfield Properties

EPA Pesticide Factsheets

This fact sheet introduces and explores the costs of site cleanup and, where cleanup leaves site contamination that restricts reuse, outlines the engineering and institutional controls and their monitoring and maintenance costs over a longer time frame.

Federated Search and the Library Web Site: A Study of Association of Research Libraries Member Web Sites

ERIC Educational Resources Information Center

Williams, Sarah C.

2010-01-01

The purpose of this study was to investigate how federated search engines are incorporated into the Web sites of libraries in the Association of Research Libraries. In 2009, information was gathered for each library in the Association of Research Libraries with a federated search engine. This included the name of the federated search service and…

Performance of engineered soil and trees in a parking lot bioswale

Treesearch

Qingfu Xiao; Gregory McPherson

2011-01-01

A bioswale integrating an engineered soil and trees was installed in a parking lot to evaluate its ability to reduce storm runoff, pollutant loading, and support tree growth. The adjacent control and treatment sites each received runoff from eight parking spaces and were identical except that there was no bioswale for the control site. A tree was planted at both sites...

Environmental assessment of SP-100 ground engineering system test site: Hanford Site, Richland, Washington

NASA Astrophysics Data System (ADS)

1988-12-01

The US Department of Energy (DOE) proposes to modify an existing reactor containment building (decommissioned Plutonium Recycle Test Reactor (PRTR) 309 Building) to provide ground test capability for the prototype SP-100 reactor. The 309 Building (Figure 1.1) is located in the 300 Area on the Hanford Site in Washington State. The National Environmental Policy Act (NEPA) requires that Federal agencies assess the potential impacts that their actions may have on the environment. This Environmental Assessment describes the consideration given to environmental impacts during reactor concept and test site selection, examines the environmental effects of the DOE proposal to ground test the nuclear subsystem, describes alternatives to the proposed action, and examines radiological risks of potential SP-100 use in space.

Desert Research and Technology Studies (RATS) 2007 Field Campaign Objectives and Results

NASA Technical Reports Server (NTRS)

Kosmo, Joseph; Romig, Barbara

2008-01-01

Desert "RATS" (Research and Technology Studies) is a combined, multi-discipline group of inter-NASA center scientists and engineers, net-working and collaborating with representatives of industry and academia, for the purpose of conducting planetary surface exploration-focused remote field exercises. These integrated testing exercises conducted under representative analog Lunar and Mars surface terrain conditions, provide NASA the capability to validate experimental prototype hardware and software systems as well as to evaluate and develop mission operational techniques in order to identify and establish technical requirements and identify potential technology "gaps" applicable for future planetary human exploration. The 2007 D-RATS field campaign test activities were initiated based on the major themes and objectives of a notional 5-year plan developed for conducting relative analog test activities in support of the engineering evaluation and assessment of various system architectural requirements, conceptual prototype support equipment and selected technologies necessary for the establishment of a lunar outpost. Specifically, the major objectives included measuring task efficiency during robot, human, and human-robot interactive tasks associated with lunar outpost site surveying and reconnaissance activities and deployment of a representative solar panel power and distribution system. In addition, technology demonstrations were conducted with a new Lithium-ion battery and autonomous software to coordinate multiple robot activities. Secondary objectives were evaluating airlock concept mockups and prototype removable space suit over-garment elements for dust mitigation, and upgrades to the prototype extravehicular activities (EVA) communication and information system. Dry run test activities, prior to testing at a designated remote field site location, were initially conducted at the Johnson Space Center (JSC) Remote Field Demonstration Test Site. This is a multi-acre external test site located at JSC and has detailed representative terrain features simulating both Lunar and Mars surface characteristics. Both the local JSC and remote field test sites have terrain conditions that are representative and characteristic of both the Moon and Mars, such as strewn rock and volcanic ash fields, craters, rolling plains, hills, gullies, slopes, and outcrops. The D-RATS 2007 field campaign, representing the completion of its tenth year of analog testing, was conducted at the large Cinder Lake volcanic ash bed area adjacent to Flagstaff, Arizona.

Energy Return On Investment of Engineered Geothermal Systems Data

DOE Data Explorer

Mansure, Chip

2012-01-01

The project provides an updated Energy Return on Investment (EROI) for Enhanced Geothermal Systems (EGS). Results incorporate Argonne National Laboratory's Life Cycle Assessment and base case assumptions consistent with other projects in the Analysis subprogram. EROI is a ratio of the energy delivered to the consumer to the energy consumed to build, operate, and decommission the facility. EROI is important in assessing the viability of energy alternatives. Currently EROI analyses of geothermal energy are either out-of-date, of uncertain methodology, or presented online with little supporting documentation. This data set is a collection of files documenting data used to calculate the Energy Return On Investment (EROI) of Engineered Geothermal Systems (EGS) and erratum to publications prior to the final report. Final report is available from the OSTI web site (http://www.osti.gov/geothermal/). Data in this collections includes the well designs used, input parameters for GETEM, a discussion of the energy needed to haul materials to the drill site, the baseline mud program, and a summary of the energy needed to drill each of the well designs. EROI is the ratio of the energy delivered to the customer to the energy consumed to construct, operate, and decommission the facility. Whereas efficiency is the ratio of the energy delivered to the customer to the energy extracted from the reservoir.

Theater Nuclear Force Survivability, Security and Safety Instrumentation. Volume I. Engineering Development Phase - Fiscal Year 1980.

DTIC Science & Technology

1980-12-31

development and acquisition program. It is generally agreed that the measures of merit in system acquisition programs are costs, schedule, and achievement...very few system acquisitions have successfully achieved their predicted measures of merit. The reasons for the poor record have been attributed to a...and Logistics -- The instrumentation must be easily maintained and easily transported to remote test sites in CONUS and Europe. 13 4. Useful Lifetime

Solar Sea Power Plants (SSPP): A critical review and survey

NASA Technical Reports Server (NTRS)

Strauss, A. M.

1974-01-01

An overview of technical and economic matters relating to the eventual success or failure of the SSPP concept is presented, with emphasis on the pollution and energy problems which the SSPP would serve to eliminate. Factors discussed include cost, mariculture possibilities, siting, legal limitations, design materials, mooring and anchoring, and the human element involved. Several alternative power systems are considered for incorporation into SSPP design, such as Nitinol power, Claude cycle, and closed cycle engine systems.

Environmental Assessment for Capital Improvement Projects, Buckley Air Force Base, Colorado. Volume 2 of 2

DTIC Science & Technology

2006-03-01

2003 Air Emission Inventory, July 2004. o The generators are assumed to be diesel-fired and have a horsepower rating of less than 600 hp. o...In July 2003, the 460th LRS purchased and installed an automated movable storage system for mobility bag storage. This system eliminates wasted aisle...Installation Restoration Program Draft Final Engineering Evaluation/Cost Analysis IRP Site 4. July . • URS Corporation (URS). 2003a. Buckley Air Force

Project Ares: A Systems Engineering and Operations Architecture for the Exploration of Mars

DTIC Science & Technology

1992-03-20

increased use of automation, experiential databases , expert systems, and fail-soft’ configurations and designs (33:252-253). Automatic communication relay and...communications satellite’s lifetimes, we assume that uplink data rates on the order of 10 Kbps should suffice for command and database uploads. Current...squashed, 20-sided polyhedron configuration which should be relatively easy to obtain. Thus, two extremes for configuration exist. At one end is the site

Advanced engineering environment collaboration project.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamph, Jane Ann; Pomplun, Alan R.; Kiba, Grant W.

2008-12-01

The Advanced Engineering Environment (AEE) is a model for an engineering design and communications system that will enhance project collaboration throughout the nuclear weapons complex (NWC). Sandia National Laboratories and Parametric Technology Corporation (PTC) worked together on a prototype project to evaluate the suitability of a portion of PTC's Windchill 9.0 suite of data management, design and collaboration tools as the basis for an AEE. The AEE project team implemented Windchill 9.0 development servers in both classified and unclassified domains and used them to test and evaluate the Windchill tool suite relative to the needs of the NWC using weaponsmore » project use cases. A primary deliverable was the development of a new real time collaborative desktop design and engineering process using PDMLink (data management tool), Pro/Engineer (mechanical computer aided design tool) and ProductView Lite (visualization tool). Additional project activities included evaluations of PTC's electrical computer aided design, visualization, and engineering calculations applications. This report documents the AEE project work to share information and lessons learned with other NWC sites. It also provides PTC with recommendations for improving their products for NWC applications.« less

Viral proteases: an emerging therapeutic target.

PubMed

Korant, B D

1988-01-01

Only a few viral diseases are presently treatable because of our limited knowledge of specific viral target molecules. An attractive class of viral molecules toward which chemotherapeutic agents could be aimed are proteases coded by some virus groups such as retro- or picornaviruses (poliomyelitis, common cold virus). The picornavirus enzymes were discovered first, and they have now been characterized by a combination of molecular-genetic and biochemical approaches. Several laboratories have expressed the picornaviral enzymes in heterologous systems and have reported proteolytic activity, as well as the high cleavage fidelity diagnostic of the viral proteases. After dealing with several technical difficulties often encountered in standard genetic engineering approaches, one viral protease is now available to us in quantity and is amendable to mutagenic procedures. The initial outcome of the mutagenesis studies has been the confirmation of our earlier work with inhibitors, which suggested a cysteine active-site class. There is a clustering of active-site residues which may be unique to these viruses. The requirement for an active-site cysteine-histidine pair in combination with detailed information on the viral cleavage sites has permitted design of selective inhibitors with attractive antiviral properties. Future goals include investigation of the structural basis for selective processing and application of the cleavage specificity to general problems in genetic engineering.

Web sites for postpartum depression: convenient, frustrating, incomplete, and misleading.

PubMed

Summers, Audra L; Logsdon, M Cynthia

2005-01-01

To evaluate the content and the technology of Web sites providing information on postpartum depression. Eleven search engines were queried using the words "Postpartum Depression." The top 10 sites in each search engine were evaluated for correct content and technology using the Web Depression Tool, based on the Technology Assessment Model. Of the 36 unique Web sites located, 34 were available to review. Only five Web sites provided >75% correct responses to questions that summarized the current state of the science for postpartum depression. Eleven of the Web sites contained little or no useful information about postpartum depression, despite being among the first 10 Web sites listed by the search engine. Some Web sites contained possibly harmful suggestions for treatment of postpartum depression. In addition, there are many problems with the technology of Web sites providing information on postpartum depression. A better Web site for postpartum depression is necessary if we are to meet the needs of consumers for accurate and current information using technology that enhances learning. Since patient education is a core competency for nurses, it is essential that nurses understand how their patients are using the World Wide Web for learning and how we can assist our patients to find appropriate sites containing correct information.

Inducible CRISPR genome-editing tool: classifications and future trends.

PubMed

Dai, Xiaofeng; Chen, Xiao; Fang, Qiuwu; Li, Jia; Bai, Zhonghu

2018-06-01

The discovery of CRISPR-Cas9/dCas9 system has reinforced our ability and revolutionized our history in genome engineering. While Cas9 and dCas9 are programed to modulate gene expression by introducing DNA breaks, blocking transcription factor recruitment or dragging functional groups towards the targeted sites, sgRNAs determine the genomic loci where the modulation occurs. The off-target problem, due to limited sgRNA specificity and genome complexity of many species, has posed concerns for the wide application of this revolutionary technique. To solve this problem and, more importantly, gain power over gene functionality and cell fate control, inducible strategies have been continuously evolved to offer tailored solutions to address specific biological questions. By reviewing recent advances in inducible CRISPR system design and critical elements potentially adding values to such systems, we classify current approaches in this domain into four mechanically distinct categories, namely, "split system", "allosteric system", "combinatorial system", and "transient delivery system", discuss the pros and cons of each system, and point out the under-explored areas and future directions, with the aim of enriching our toolbox of delicate life engineering.

Heat-pump-centered integrated community energy systems: Systems development, Consolidated Natural Gas Service Company

NASA Astrophysics Data System (ADS)

Baker, N. R.; Donakowski, T. D.; Foster, R. B.; Sala, D. L.; Tison, R. R.; Whaley, T. P.; Yudow, B. D.; Swenson, P. F.

1980-01-01

The heat actuated heat pump centered integrated community energy system (HAHP-ICES) is described. The system utilizes a gas fired, engine-driven, heat pump and commercial buildings, and offers several advantages over the more conventional equipment it is intended to supplant. The general nonsite specific application assumes a hypothetical community of one 59,000 cu ft office building and five 24 unit, low rise apartment buildings located in a region with a climate similar to Chicago. Various sensitivity analyses are performed and through which the performance characteristics of the HAHP are explored. The results provided the selection criteria for the site specific application of the HAHP-ICES concept to a real world community. The site-specific community consists of: 42 town houses; five 120 unit, low rise apartment buildings; five 104 unit high rise apartment buildings; one 124,000 cu ft office building; and a single 135,000 cu ft retail building.

Site-Specific Cassette Exchange Systems in the Aedes aegypti Mosquito and the Plutella xylostella Moth

PubMed Central

Haghighat-Khah, Roya Elaine; Scaife, Sarah; Martins, Sara; St John, Oliver; Matzen, Kelly Jean; Morrison, Neil; Alphey, Luke

2015-01-01

Genetically engineered insects are being evaluated as potential tools to decrease the economic and public health burden of mosquitoes and agricultural pest insects. Here we describe a new tool for the reliable and targeted genome manipulation of pest insects for research and field release using recombinase mediated cassette exchange (RMCE) mechanisms. We successfully demonstrated the established ΦC31-RMCE method in the yellow fever mosquito, Aedes aegypti, which is the first report of RMCE in mosquitoes. A new variant of this RMCE system, called iRMCE, combines the ΦC31-att integration system and Cre or FLP-mediated excision to remove extraneous sequences introduced as part of the site-specific integration process. Complete iRMCE was achieved in two important insect pests, Aedes aegypti and the diamondback moth, Plutella xylostella, demonstrating the transferability of the system across a wide phylogenetic range of insect pests. PMID:25830287

Snore related signals processing in a private cloud computing system.

PubMed

Qian, Kun; Guo, Jian; Xu, Huijie; Zhu, Zhaomeng; Zhang, Gongxuan

2014-09-01

Snore related signals (SRS) have been demonstrated to carry important information about the obstruction site and degree in the upper airway of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) patients in recent years. To make this acoustic signal analysis method more accurate and robust, big SRS data processing is inevitable. As an emerging concept and technology, cloud computing has motivated numerous researchers and engineers to exploit applications both in academic and industry field, which could have an ability to implement a huge blue print in biomedical engineering. Considering the security and transferring requirement of biomedical data, we designed a system based on private cloud computing to process SRS. Then we set the comparable experiments of processing a 5-hour audio recording of an OSAHS patient by a personal computer, a server and a private cloud computing system to demonstrate the efficiency of the infrastructure we proposed.

Compliance program data management system for The Idaho National Engineering Laboratory/Environmental Protection Agency

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hertzler, C.L.; Poloski, J.P.; Bates, R.A.

1988-01-01

The Compliance Program Data Management System (DMS) developed at the Idaho National Engineering Laboratory (INEL) validates and maintains the integrity of data collected to support the Consent Order and Compliance Agreement (COCA) between the INEL and the Environmental Protection Agency (EPA). The system uses dBase III Plus programs and dBase III Plus in an interactive mode to enter, store, validate, manage, and retrieve analytical information provided on EPA Contract Laboratory Program (CLP) forms and CLP forms modified to accommodate 40 CFR 264 Appendix IX constituent analyses. Data analysis and presentation is performed utilizing SAS, a statistical analysis software program. Archivingmore » of data and results is performed at appropriate stages of data management. The DMS is useful for sampling and analysis programs where adherence to EPA CLP protocol, along with maintenance and retrieval of waste site investigation sampling results is desired or requested. 3 refs.« less

Study of water supply & sanitation practices in India using geographic information systems: some design & other considerations in a village setting.

PubMed

Gopal, Srila; Sarkar, Rajiv; Banda, Kalyan; Govindarajan, Jeyanthi; Harijan, B B; Jeyakumar, M B; Mitta, Philip; Sadanala, M E; Selwyn, Tryphena; Suresh, C R; Thomas, V A; Devadason, Pethuru; Kumar, Ranjit; Selvapandian, David; Kang, Gagandeep; Balraj, Vinohar

2009-03-01

Availability of clean water and adequate sanitation facilities are of prime importance for limiting diarrhoeal diseases. We examined the water and sanitation facilities of a village in southern India using geographic information system (GIS) tools. Places of residence, water storage and distribution, sewage and places where people in the village defaecated were mapped and drinking water sources were tested for microbial contamination in Nelvoy village, Vellore district, Tamil Nadu. Water in the village was found to be microbiologically unfit for consumption. Analysis using direct observations supplemented by GIS maps revealed poor planning, poor engineering design and lack of policing of the water distribution system causing possible contamination of drinking water from sewage at multiple sites. Until appropriate engineering designs for water supply and sewage disposal to suit individual village needs are made available, point-of-use water disinfection methods could serve as an interim solution.

Cogeneration Technology Alternatives Study (CTAS). Volume 1: Summary

NASA Technical Reports Server (NTRS)

Barna, G. J.; Burns, R. K.; Sagerman, G. D.

1980-01-01

Various advanced energy conversion systems that can use coal or coal-derived fuels for industrial cogeneration applications were compared to provide information needed by DOE to establish research and development funding priorities for advanced-technology systems that could significantly advance the use of coal or coal-derived fuels in industrial cogeneration. Steam turbines, diesel engines, open-cycle gas turbines, combined cycles, closed-cycle gas turbines, Stirling engines, phosphoric acid fuel cells, molten carbonate fuel cells, and thermionics were studied with technology advancements appropriate for the 1985-2000 time period. The various advanced systems were compared and evaluated for wide diversity of representative industrial plants on the basis of fuel energy savings, annual energy cost savings, emissions savings, and rate of return on investment as compared with purchasing electricity from a utility and providing process heat with an on-site boiler. Also included in the comparisons and evaluations are results extrapolated to the national level.

Cogeneration Technology Alternatives Study (CTAS). Volume 2: Comparison and evaluation of results

NASA Technical Reports Server (NTRS)

1984-01-01

CTAS compared and evaluated various advanced energy conversion systems that can use coal or coal-derived fuels for industrial cogeneration applications. The principal aim of the study was to provide information needed by DOE to establish research and development (R&D) funding priorities for advanced-technology systems that could significantly advance the use of coal or coal-derived fuels in industrial cogeneration. Steam turbines, diesel engines, open-cycle gas turbines, combined cycles, closed-cycle gas turbines, Stirling engines, phosphoric acid fuel cells, molten carbonate fuel cells, and thermionics were studied with technology advancements appropriate for the 1985-2000 time period. The various advanced systems were compared and evaluated for a wide diversity of representative industrial plants on the basis of fuel energy savings, annual energy cost savings, emissions savings, and rate of return on investment (ROI) as compared with purchasing electricity from a utility and providing process heat with an on-site boiler.

Sort-Seq Approach to Engineering a Formaldehyde-Inducible Promoter for Dynamically Regulated Escherichia coli Growth on Methanol

PubMed Central

2017-01-01

Tight and tunable control of gene expression is a highly desirable goal in synthetic biology for constructing predictable gene circuits and achieving preferred phenotypes. Elucidating the sequence–function relationship of promoters is crucial for manipulating gene expression at the transcriptional level, particularly for inducible systems dependent on transcriptional regulators. Sort-seq methods employing fluorescence-activated cell sorting (FACS) and high-throughput sequencing allow for the quantitative analysis of sequence–function relationships in a robust and rapid way. Here we utilized a massively parallel sort-seq approach to analyze the formaldehyde-inducible Escherichia coli promoter (Pfrm) with single-nucleotide resolution. A library of mutated formaldehyde-inducible promoters was cloned upstream of gfp on a plasmid. The library was partitioned into bins via FACS on the basis of green fluorescent protein (GFP) expression level, and mutated promoters falling into each expression bin were identified with high-throughput sequencing. The resulting analysis identified two 19 base pair repressor binding sites, one upstream of the −35 RNA polymerase (RNAP) binding site and one overlapping with the −10 site, and assessed the relative importance of each position and base therein. Key mutations were identified for tuning expression levels and were used to engineer formaldehyde-inducible promoters with predictable activities. Engineered variants demonstrated up to 14-fold lower basal expression, 13-fold higher induced expression, and a 3.6-fold stronger response as indicated by relative dynamic range. Finally, an engineered formaldehyde-inducible promoter was employed to drive the expression of heterologous methanol assimilation genes and achieved increased biomass levels on methanol, a non-native substrate of E. coli. PMID:28463494

A Subject Matter Expert View of Curriculum Development.

NASA Astrophysics Data System (ADS)

Milazzo, M. P.; Anderson, R. B.; Edgar, L. A.; Gaither, T. A.; Vaughan, R. G.

2017-12-01

In 2015, NASA selected for funding the PLANETS project: Planetary Learning that Advances the Nexus of Engineering, Technology, and Science. The PLANETS partnership develops planetary science and engineering curricula for out of classroom time (OST) education settings. This partnership is between planetary science Subject Matter Experts (SMEs) at the US Geological Survey (USGS), curriculum developers at the Boston Museum of Science (MOS) Engineering is Everywhere (EiE), science and engineering teacher professional development experts at Northern Arizona University (NAU) Center for Science Teaching and Learning (CSTL), and OST teacher networks across the world. For the 2016 and 2017 Fiscal Years, our focus was on creating science material for two OST modules designed for middle school students. We have begun development of a third module for elementary school students. The first model teaches about the science and engineering of the availability of water in the Solar System, finding accessible water, evaluating it for quality, treating it for impurities, initial use, a cycle of greywater treatment and re-use, and final treatment of blackwater. This module is described in more detail in the abstract by L. Edgar et al., Water in the Solar System: The Development of Science Education Curriculum Focused on Planetary Exploration (233008) The second module involves the science and engineering of remote sensing in planetary exploration. This includes discussion and activities related to the electromagnetic spectrum, spectroscopy and various remote sensing systems and techniques. In these activities and discussions, we include observation and measurement techniques and tools as well as collection and use of specific data of interest to scientists. This module is described in more detail in the abstract by R. Anderson et al., Remote Sensing Mars Landing Sites: An Out-of-School Time Planetary Science Education Activity for Middle School Students (232683) The third module, described by R.G. Vaughan, Hazards in the Solar System: Out-of-School Time Student Activities Focused on Engineering Protective Space Gloves (262143), focuses on hazards in the Solar System and the engineering approach to designing space gloves to protect against those hazards.

Design of Single-Site Photocatalyst using Metal-Organic Framework as Matrix.

PubMed

Wen, Meicheng; Mori, Kohsuke; Kuwahara, Yasutaka; An, Taicheng; Yamashita, Hiromi

2018-05-14

Single-site photocatalyst generally displays excellent photocatalytic activtiy and considerable high stability as compared to homogeneous catalytic system. A rational structural design of single-site photocatalyst with isolated, uniform and spatially separated active sites in a given solid is of prime importance to achieve high photocatalytic activity. Intense attentions have been focused on the engineering and fabrication of single-site photocatalys by using porous materials as platform. Metal-organic frameworks (MOFs) hold great potential for the design and fabrication of single-site photocatalysts due to their remarkable porosity, ultrahigh surface area, extraordinary tailorability and significant diversity. MOFs can provide abundant number of binding sites for anchoring active sites, result in significant enhancement of photocatalytic performance. In this focus review, the development of single-site MOF photocatalysts that perform in important and challenging chemical redox reaction such as photocatalytic water splitting, photocatalytic CO₂ conversion and organic transformations is summarized thoroughly. The successful strategies applied for the construction of single-site MOF photocatalysts and major challenge toward practical application was summarized and pointed out, respectively. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Periodontal tissue engineering strategies based on nonoral stem cells.

PubMed

Requicha, João Filipe; Viegas, Carlos Alberto; Muñoz, Fernando; Reis, Rui Luís; Gomes, Manuela Estima

2014-01-01

Periodontal disease is an inflammatory disease which constitutes an important health problem in humans due to its enormous prevalence and life threatening implications on systemic health. Routine standard periodontal treatments include gingival flaps, root planning, application of growth/differentiation factors or filler materials and guided tissue regeneration. However, these treatments have come short on achieving regeneration ad integrum of the periodontium, mainly due to the presence of tissues from different embryonic origins and their complex interactions along the regenerative process. Tissue engineering (TE) aims to regenerate damaged tissue by providing the repair site with a suitable scaffold seeded with sufficient undifferentiated cells and, thus, constitutes a valuable alternative to current therapies for the treatment of periodontal defects. Stem cells from oral and dental origin are known to have potential to regenerate these tissues. Nevertheless, harvesting cells from these sites implies a significant local tissue morbidity and low cell yield, as compared to other anatomical sources of adult multipotent stem cells. This manuscript reviews studies describing the use of non-oral stem cells in tissue engineering strategies, highlighting the importance and potential of these alternative stem cells sources in the development of advanced therapies for periodontal regeneration. Copyright © 2013 Wiley Periodicals, Inc.

Summary of the engineering assessment of inactive uranium mill tailings, Durango Site, Durango, Colorado

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-06-01

Ford, Bacon and Davis Utah Inc. has reevaluated the Durango site in order to revise the November 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Durango, Colorado. This engineering assessment has included the preparation of topographic measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the nearly 1.6 million tons of tailings at the Durango site constitutes the most significant environmental impact, although windblownmore » tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite and off-site decontamination with the addition of 3 m of stabilization cover material (Option I), to removal of the tailings to remote disposal sites and decontamination of the tailings site (Options II through IV). Cost estimates for the seven options range from about $10,700,000 for stabilization in-place, to about $21,800,000 for disposal at a distance of about 10 mi. Three principal alternatives for the reprocessing of the Durango tailings were examined: (a) heap leaching; (b) treatment at an existing mill; and (c) reprocessing at a new conventional mill constructed for tailings reprocessing.« less

SHARP's systems engineering challenge: rectifying integrated product team requirements with performance issues in an evolutionary spiral development acquisition

NASA Astrophysics Data System (ADS)

Kuehl, C. Stephen

2003-08-01

Completing its final development and early deployment on the Navy's multi-role aircraft, the F/A-18 E/F Super Hornet, the SHAred Reconnaissance Pod (SHARP) provides the war fighter with the latest digital tactical reconnaissance (TAC Recce) Electro-Optical/Infrared (EO/IR) sensor system. The SHARP program is an evolutionary acquisition that used a spiral development process across a prototype development phase tightly coupled into overlapping Engineering and Manufacturing Development (EMD) and Low Rate Initial Production (LRIP) phases. Under a tight budget environment with a highly compressed schedule, SHARP challenged traditional acquisition strategies and systems engineering (SE) processes. Adopting tailored state-of-the-art systems engineering process models allowd the SHARP program to overcome the technical knowledge transition challenges imposed by a compressed program schedule. The program's original goal was the deployment of digital TAC Recce mission capabilities to the fleet customer by summer of 2003. Hardware and software integration technical challenges resulted from requirements definition and analysis activities performed across a government-industry led Integrated Product Team (IPT) involving Navy engineering and test sites, Boeing, and RTSC-EPS (with its subcontracted hardware and government furnished equipment vendors). Requirements development from a bottoms-up approach was adopted using an electronic requirements capture environment to clarify and establish the SHARP EMD product baseline specifications as relevant technical data became available. Applying Earned-Value Management (EVM) against an Integrated Master Schedule (IMS) resulted in efficiently managing SE task assignments and product deliveries in a dynamically evolving customer requirements environment. Application of Six Sigma improvement methodologies resulted in the uncovering of root causes of errors in wiring interconnectivity drawings, pod manufacturing processes, and avionics requirements specifications. Utilizing the draft NAVAIR SE guideline handbook and the ANSI/EIA-632 standard: Processes for Engineering a System, a systems engineering tailored process approach was adopted for the accelerated SHARP EMD prgram. Tailoring SE processes in this accelerated product delivery environment provided unique opportunities to be technically creative in the establishment of a product performance baseline. This paper provides an historical overview of the systems engineering activities spanning the prototype phase through the EMD SHARP program phase, the performance requirement capture activities and refinement process challenges, and what SE process improvements can be applied to future SHARP-like programs adopting a compressed, evolutionary spiral development acquisition paradigm.

Size-resolved source apportionment of carbonaceous particulate matter in urban and rural sites in central California

NASA Astrophysics Data System (ADS)

Ham, Walter A.; Kleeman, Michael J.

2011-08-01

Very little is currently known about the relationship between exposure to different sources of ambient ultrafine particles (PM 0.1) and human health effects. If human health effects are enhanced by PM 0.1's ability to cross cell membranes, then more information is needed describing the sources of ultrafine particles that are deposited in the human respiratory system. The current study presents results for the source apportionment of airborne particulate matter in six size fractions smaller than 1.8 μm particle diameter including ultrafine particles (PM 0.1) in one of the most polluted air basins in the United States. Size-resolved source apportionment results are presented at an urban site and rural site in central California's heavily polluted San Joaquin Valley during the winter and summer months using a molecular marker chemical mass balance (MM-CMB) method. Respiratory deposition calculations for the size-resolved source apportionment results are carried out with the Multiple Path Particle Dosimetry Model ( MPPD v 2.0), including calculations for ultrafine (PM 0.1) source deposition. Diesel engines accounted for the majority of PM 0.1 and PM 1.8 EC at both the urban and rural sampling locations during both summer and winter seasons. Meat cooking accounted for 33-67% and diesel engines accounted for 15-21% of the PM 0.1 OC at Fresno. Meat cooking accounted for 22-26% of the PM 0.1 OC at the rural Westside location, while diesel engines accounted for 8-9%. Wood burning contributions to PM 0.1 OC increased to as much as 12% of PM 0.1 OC during the wintertime. The modest contribution of wood smoke reflects the success of emissions control programs over the past decade. In contrast to PM 0.1, PM 1.8 OC had a higher fraction of unidentified source contributions (68-85%) suggesting that this material is composed of secondary organic aerosol (SOA) or primary organic aerosol (POA) that has been processed by atmospheric chemical reactions. Meat cooking was the largest identified source of PM 1.8 organic carbon (OC) at the Fresno site (12-13%) while diesel engines were the largest identified PM 1.8 OC source at the rural site (5-8%). Wood burning contributions to PM 1.8 OC increased during the wintertime at both sites (6-9%) but were relatively small during the summertime (˜1%). As expected, diesel engines were the dominant source of PM 0.1 EC respiratory deposition at both the urban and rural site in both summer and winter (0.01-0.03 μg PM 0.1 EC deposited per m 3 air inhaled). Meat cooking accounted for 0.01-0.025 μg PM 0.1 OC deposited per m 3 air inhaled while diesel fuel accounted for 0.005-0.013 μg PM 0.1 OC deposited per m 3 air inhaled. Minor contributions from wood burning, motor oil, and gasoline fuel were calculated at levels <0.005 μg PM 0.1 OC deposited per m 3 air inhaled at both urban and rural locations during winter and summer seasons. If the burden of PM 0.1 deposited in the respiratory system is relevant for human health effects, then future toxicology studies should be carried out at PM 0.1 concentrations and source mixtures equivalent to those measured in the current study.

10 CFR 100.10 - Factors to be considered when evaluating sites.

Code of Federal Regulations, 2013 CFR

2013-01-01

... reactor incorporates unique or unusual features having a significant bearing on the probability or consequences of accidental release of radioactive materials; (4) The safety features that are to be engineered... radioactive fission products. In addition, the site location and the engineered features included as...

10 CFR 100.10 - Factors to be considered when evaluating sites.

Code of Federal Regulations, 2012 CFR

2012-01-01

... reactor incorporates unique or unusual features having a significant bearing on the probability or consequences of accidental release of radioactive materials; (4) The safety features that are to be engineered... radioactive fission products. In addition, the site location and the engineered features included as...

10 CFR 100.10 - Factors to be considered when evaluating sites.

Code of Federal Regulations, 2014 CFR

2014-01-01

... reactor incorporates unique or unusual features having a significant bearing on the probability or consequences of accidental release of radioactive materials; (4) The safety features that are to be engineered... radioactive fission products. In addition, the site location and the engineered features included as...

Multi-criteria GIS-based siting of transfer station for municipal solid waste: The case of Kumasi Metropolitan Area, Ghana.

PubMed

Bosompem, Christian; Stemn, Eric; Fei-Baffoe, Bernard

2016-10-01

The increase in the quantity of municipal solid waste generated as a result of population growth in most urban areas has resulted in the difficulty of locating suitable land areas to be used as landfills. To curb this, waste transfer stations are used. The Kumasi Metropolitan Area, even though it has an engineered landfill, is faced with the problem of waste collection from the generation centres to the final disposal site. Thus in this study, multi-criteria decision analysis incorporated into a geographic information system was used to determine potential waste transfer station sites. The key result established 11 sites located within six different sub-metros. This result can be used by decision makers for site selection of the waste transfer stations after taking into account other relevant ecological and economic factors. © The Author(s) 2016.

Deep Borehole Disposal Safety Analysis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freeze, Geoffrey A.; Stein, Emily; Price, Laura L.

This report presents a preliminary safety analysis for the deep borehole disposal (DBD) concept, using a safety case framework. A safety case is an integrated collection of qualitative and quantitative arguments, evidence, and analyses that substantiate the safety, and the level of confidence in the safety, of a geologic repository. This safety case framework for DBD follows the outline of the elements of a safety case, and identifies the types of information that will be required to satisfy these elements. At this very preliminary phase of development, the DBD safety case focuses on the generic feasibility of the DBD concept.more » It is based on potential system designs, waste forms, engineering, and geologic conditions; however, no specific site or regulatory framework exists. It will progress to a site-specific safety case as the DBD concept advances into a site-specific phase, progressing through consent-based site selection and site investigation and characterization.« less

DARPA/USAF/USN J-UCAS X-45A System Demonstration Program: A Review of Flight Test Site Processes and Personnel

NASA Technical Reports Server (NTRS)

Cosentino, Gary B.

2008-01-01

The Joint Unmanned Combat Air Systems (J-UCAS) program is a collaborative effort between the Defense Advanced Research Project Agency (DARPA), the US Air Force (USAF) and the US Navy (USN). Together they have reviewed X-45A flight test site processes and personnel as part of a system demonstration program for the UCAV-ATD Flight Test Program. The goal was to provide a disciplined controlled process for system integration and testing and demonstration flight tests. NASA's Dryden Flight Research Center (DFRC) acted as the project manager during this effort and was tasked with the responsibilities of range and ground safety, the provision of flight test support and infrastructure and the monitoring of technical and engineering tasks. DFRC also contributed their engineering knowledge through their contributions in the areas of autonomous ground taxi control development, structural dynamics testing and analysis and the provision of other flight test support including telemetry data, tracking radars, and communications and control support equipment. The Air Force Flight Test Center acted at the Deputy Project Manager in this effort and was responsible for the provision of system safety support and airfield management and air traffic control services, among other supporting roles. The T-33 served as a J-UCAS surrogate aircraft and demonstrated flight characteristics similar to that of the the X-45A. The surrogate served as a significant risk reduction resource providing mission planning verification, range safety mission assessment and team training, among other contributions.

Chilled water study EEAP program for Walter Reed Army Medical Center: Book 2. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-02-01

The Energy Engineering Analysis Program (EEAP) Study for Walter Reed Army Medical Center (WRAMC) was to provide a thorough examination of the central chilled water plants on site. WRAMC is comprised of seventy-one (71) buildings located on a 113-acre site in Washington, D.C. There are two (2) central chilled water plants (Buildings 48 and 49) each with a primary chilled water distribution system. In addition to the two (2) central plants, three (3) buildings utilize their own independent chillers. Two (2) of the independent chillers (Buildings 7 and T-2), one of which is inoperative (T-2), are smaller air-cooled units, whilemore » the third (Building 54) has a 1,900-ton chilled water plant comprised of three (3) centrifugal chillers. Of the two (2) central chilled water plants, Building 48 houses six (6) chillers totalling 7,080 tons of cooling and Building 49 houses one (1) chiller with 660 tons of cooling. The total chiller cooling capacity available on site is 9,840 tons. The chilled water systems were reviewed for alternative ways of conserving energy on site and reducing the peak-cooling load. Distribution systems were reviewed to determine which buildings were served by each of the chilled water plants and to determine chilled water usage on site. Evaluations were made of building exterior and interior composition in order to estimate cooling loads. Interviews with site personnel helped Entech better understand the chilled water plants, the distribution systems, and how each system was utilized.« less

Confinement of gene drive systems to local populations: A comparative analysis

PubMed Central

Marshall, John M.; Hay, Bruce A.

2011-01-01

Mosquito-borne diseases such as malaria and dengue fever pose a major health problem through much of the world. One approach to disease prevention involves the use of selfish genetic elements to drive disease-refractory genes into wild mosquito populations. Recently engineered synthetic drive systems have provided encouragement for this strategy; but at the same time have been greeted with caution over the concern that transgenes may spread into countries and communities without their consent. Consequently, there is also interest in gene drive systems that, while strong enough to bring about local population replacement, are unable to establish themselves beyond a partially-isolated release site, at least during the testing phase. Here, we develop simple deterministic and stochastic models to compare the confinement properties of a variety of gene drive systems. Our results highlight several systems with desirable features for confinement – a high migration rate required to become established in neighboring populations, and low-frequency persistence in neighboring populations for moderate migration rates. Single-allele underdominance and single-locus engineered underdominance have the strongest confinement properties, but are difficult to engineer and require a high introduction frequency, respectively. Toxin-antidote systems such as Semele, Merea and two-locus engineered underdominance show promising confinement properties and require lower introduction frequencies. Killer-rescue is self-limiting in time, but is able to disperse to significant levels in neighboring populations. We discuss the significance of these results in the context of a phased release of transgenic mosquitoes, and the need for characterization of local ecology prior to a release. PMID:22094363

Engineering of a Bacillus subtilis strain with adjustable levels of intracellular biotin for secretory production of functional streptavidin.

PubMed

Wu, Sau-Ching; Wong, Sui-Lam

2002-03-01

Streptavidin is a biotin-binding protein which has been widely used in many in vitro and in vivo applications. Because of the ease of protein recovery and availability of protease-deficient strains, the Bacillus subtilis expression-secretion system is an attractive system for streptavidin production. However, attempts to produce streptavidin using B. subtilis face the problem that cells overproducing large amounts of streptavidin suffer poor growth, presumably because of biotin deficiency. This problem cannot be solved by supplementing biotin to the culture medium, as this will saturate the biotin binding sites in streptavidin. We addressed this dilemma by engineering a B. subtilis strain (WB800BIO) which overproduces intracellular biotin. The strategy involves replacing the natural regulatory region of the B. subtilis chromosomal biotin biosynthetic operon (bioWAFDBIorf2) with an engineered one consisting of the B. subtilis groE promoter and gluconate operator. Biotin production in WB800BIO is induced by gluconate, and the level of biotin produced can be adjusted by varying the gluconate dosage. A level of gluconate was selected to allow enhanced intracellular production of biotin without getting it released into the culture medium. WB800BIO, when used as a host for streptavidin production, grows healthily in a biotin-limited medium and produces large amounts (35 to 50 mg/liter) of streptavidin, with over 80% of its biotin binding sites available for future applications.

Alleviation of Thermal Strain in Engineering Space Personnel Aboard CF Ships with the Exotemp Personal Cooling System

DTIC Science & Technology

1991-06-01

and Mr. Robert 0 Limmer , which in the face of severe motion sickness often approached heroic proportions, was very much appreciated. 37 REFERENCES 1...SD, Grayson J, Frim J, Allen CL, and Limmer RE. Effect of cold exposure on various sites of core temperature measurements. J Appl Physiol 54:1025-1031

Computer networks for remote laboratories in physics and engineering

NASA Technical Reports Server (NTRS)

Starks, Scott; Elizandro, David; Leiner, Barry M.; Wiskerchen, Michael

1988-01-01

This paper addresses a relatively new approach to scientific research, telescience, which is the conduct of scientific operations in locations remote from the site of central experimental activity. A testbed based on the concepts of telescience is being developed to ultimately enable scientific researchers on earth to conduct experiments onboard the Space Station. This system along with background materials are discussed.

Shelterwood-Strip Harvesting Pattern With Full-Tree Skidding to Regenerate Red Pine

Treesearch

John W. Benzie; Z.A. Zasada

1972-01-01

Describes a harvesting and regeneration pattern for red pine stands to make efficient use of mechanized full-tree harvesting. The system is not just an engineering operation to extract trees, but a forest management operatioin to harvest mature timber, prepare the site for regeneration, and provide environmental conditions favoring tree growth and multiple-use of the...

Morpheus Alhat Tether Test Preparations

NASA Image and Video Library

2014-03-27

CAPE CANAVERAL, Fla. – Engineers and technicians prepare the Project Morpheus prototype lander for a tether test near a new launch site at the north end of the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. The launch pad was moved to a different location at the landing facility to support the next phase of flight testing. Project Morpheus tests NASA’s automated landing and hazard avoidance technology, or ALHAT, and an engine that runs on liquid oxygen and methane, or green propellants, into a fully-operational lander that could deliver cargo to other planetary surfaces. The landing facility provides the lander with the kind of field necessary for realistic testing, complete with rocks, craters and hazards to avoid. Morpheus’ ALHAT payload allows it to navigate to clear landing sites amidst rocks, craters and other hazards during its descent. Project Morpheus is being managed under the Advanced Exploration Systems, or AES, Division in NASA’s Human Exploration and Operations Mission Directorate. The efforts in AES pioneer new approaches for rapidly developing prototype systems, demonstrating key capabilities and validating operational concepts for future human missions beyond Earth orbit. For more information on Project Morpheus, visit http://morpheuslander.jsc.nasa.gov/. Photo credit: NASA/Ben Smegelsky

Antibody-cytokine fusion proteins for treatment of cancer: engineering cytokines for improved efficacy and safety.

PubMed

Young, Patricia A; Morrison, Sherie L; Timmerman, John M

2014-10-01

The true potential of cytokine therapies in cancer treatment is limited by the inability to deliver optimal concentrations into tumor sites due to dose-limiting systemic toxicities. To maximize the efficacy of cytokine therapy, recombinant antibody-cytokine fusion proteins have been constructed by a number of groups to harness the tumor-targeting ability of monoclonal antibodies. The aim is to guide cytokines specifically to tumor sites where they might stimulate more optimal anti-tumor immune responses while avoiding the systemic toxicities of free cytokine therapy. Antibody-cytokine fusion proteins containing interleukin (IL)-2, IL-12, IL-21, tumor necrosis factor (TNF)α, and interferons (IFNs) α, β, and γ have been constructed and have shown anti-tumor activity in preclinical and early-phase clinical studies. Future priorities for development of this technology include optimization of tumor targeting, bioactivity of the fused cytokine, and choice of appropriate agents for combination therapies. This review is intended to serve as a framework for engineering an ideal antibody-cytokine fusion protein, focusing on previously developed constructs and their clinical trial results. Copyright © 2014 Elsevier Inc. All rights reserved.

Enterocin A Mutants Identified by Saturation Mutagenesis Enhance Potency Towards Vancomycin-Resistant Enterococci

PubMed Central

McClintock, Maria K.; Kaznessis, Yiannis N.; Hackel, Benjamin J.

2016-01-01

Vancomycin-resistant Enterococci infections are a significant clinical problem. One proposed solution is to use probiotics, such as lactic acid bacteria, to produce antimicrobial peptides at the site of infection. Enterocin A, a class 2a bacteriocin, exhibits inhibitory activity against E. faecium and E. faecalis, which account for 86% of vancomycin-resistant Enterococci infections. In this study, we aimed to engineer enterocin A mutants with enhanced potency within a lactic acid bacterial production system. Peptide mutants resulting from saturation mutagenesis at sites A24 and T27 were efficiently screened in a 96-well plate assay for inhibition of pathogen growth. Several mutants exhibit increased potency relative to wild-type enterocin A in both liquid- and solid-medium growth assays. In particular, A24P and T27G exhibit enhanced inhibition of multiple strains of E. faecium and E. faecalis, including clinically isolated vancomycin-resistant strains. A24P and T27G enhance killing of E. faecium 8 by 13±3- and 18±4-fold, respectively. The engineered enterocin A/lactic acid bacteria systems offer significant potential to combat antibiotic-resistant infections. PMID:26191783

Enterocin A mutants identified by saturation mutagenesis enhance potency towards vancomycin-resistant Enterococci.

PubMed

McClintock, Maria K; Kaznessis, Yiannis N; Hackel, Benjamin J

2016-02-01

Vancomycin-resistant Enterococci infections are a significant clinical problem. One proposed solution is to use probiotics, such as lactic acid bacteria, to produce antimicrobial peptides at the site of infection. Enterocin A, a class 2a bacteriocin, exhibits inhibitory activity against E. faecium and E. faecalis, which account for 86% of vancomycin-resistant Enterococci infections. In this study, we aimed to engineer enterocin A mutants with enhanced potency within a lactic acid bacterial production system. Peptide mutants resulting from saturation mutagenesis at sites A24 and T27 were efficiently screened in a 96-well plate assay for inhibition of pathogen growth. Several mutants exhibit increased potency relative to wild-type enterocin A in both liquid- and solid-medium growth assays. In particular, A24P and T27G exhibit enhanced inhibition of multiple strains of E. faecium and E. faecalis, including clinically isolated vancomycin-resistant strains. A24P and T27G enhance killing of E. faecium 8 by 13 ± 3- and 18 ± 4-fold, respectively. The engineered enterocin A/lactic acid bacteria systems offer significant potential to combat antibiotic-resistant infections. © 2015 Wiley Periodicals, Inc.

Overview of engineering activities at the SMA

NASA Astrophysics Data System (ADS)

Christensen, R. D.; Kubo, D. Y.; Rao, Ramprasad

2008-07-01

The Submillmeter Array (SMA) consists of 8 6-meter telescopes on the summit of Mauna Kea. The array has been designed to operate from the summit of Mauna Kea and from 3 remote facilities: Hilo, Hawaii, Cambridge, Massachusetts and Taipei, Taiwan. The SMA provides high-resolution scientific observations in most of the major atmospheric windows from 180 to 700 GHz. Each telescope can house up to 8 receivers in a single cryostat and can operate with one or two receiver bands simultaneously. The array being a fully operational observatory, the demand for science time is extremely high. As a result specific time frames have been set-aside during both the day and night for engineering activities. This ensures that the proper amount of time can be spent on maintaining existing equipment or upgrading the system to provide high quality scientific output during nighttime observations. This paper describes the methods employed at the SMA to optimize engineering development of the telescopes and systems such that the time available for scientific observations is not compromised. It will also examine some of the tools used to monitor the SMA during engineering and science observations both at the site and remote facilities.

Recommendations for a wind profiling network to support Space Shuttle launches

NASA Technical Reports Server (NTRS)

Zamora, R. J.

1992-01-01

The feasibility is examined of a network of clear air radar wind profilers to forecast wind conditions before Space Shuttle launches during winter. Currently, winds are measured only in the vicinity of the shuttle launch site and wind loads on the launch vehicle are estimated using these measurements. Wind conditions upstream of the Cape are not monitored. Since large changes in the wind shear profile can be associated with weather systems moving over the Cape, it may be possible to improve wind forecasts over the launch site if wind measurements are made upstream. A radar wind profiling system is in use at the Space Shuttle launch site. This system can monitor the wind profile continuously. The existing profiler could be combined with a number of radars located upstream of the launch site. Thus, continuous wind measurements would be available upstream and at the Cape. NASA-Marshall representatives have set the requirements for radar wind profiling network. The minimum vertical resolution of the network must be set so that the wind shears over the depths greater than or = 1 km will be detected. The network should allow scientists and engineers to predict the wind profile over the Cape 6 hours before a Space Shuttle launch.

Microbiological monitoring in geothermal plants and a cold storage

NASA Astrophysics Data System (ADS)

Alawi, Mashal; Lerm, Stephanie; Vieth, Andrea; Vetter, Alexandra; Miethling-Graff, Rona; Seibt, Andrea; Wolfgramm, Markus; Würdemann, Hilke

2010-05-01

Enhanced process understanding of engineered geothermal systems is mandatory to optimize plant reliability and economy. In the scope of the research project 'AquiScreen' we investigated geothermally used groundwater systems under microbial, geochemical, mineralogical and petrological aspects. Geothermal systems located in the North German Basin and the Molasse Basin were analyzed by sampling of fluids and solid phases. The investigated sites were characterized by different temperatures, salinities and potential microbial substrates. The microbial population was analyzed by the use of genetic fingerprinting techniques based on PCR-amplified 16S rRNA genes. Sequencing of dominant bands of fingerprints from different sites and the subsequent comparison on public databases enables a correlation to metabolic classes and provides information about the biochemical processes. In all investigated geothermal plants covering a temperature range from 45° to 120° C microorganisms were found. Phylogenetic gene analyses indicate a broad diversity of microorganisms adapted to the specific conditions in the engineered system. Beside characterized bacteria like Thermus scotoductus, Siderooxidans lithoautotrophicus and the archaeon Methanothermobacter thermoautotrophicus a high number of so far uncultivated microorganisms was detected. As it is known that -in addition to abiotic factors- microbes like sulfate-reducing bacteria (SRB) are involved in the processes of corrosion and scaling in plant components we identified SRB by specific analyses of dissimilatoric sulfite reductase genes. The SRB detected are closely related to thermotolerant and thermophilic species of Desulfotomaculum, Thermodesulfovibrio and Thermodesulfobacterium, respectively. Overall, the detection of microbes known to be involved in biocorrosion and examined precipitation products like iron sulfides are indicating that microorganisms play an important role for the understanding of processes in engineered geothermal systems. Furthermore, an observed reduction of the filter operation times in a cold storage could be traced back to an enhanced growth of a filamentous iron-oxidizing bacterium related to Thiotrix. The further identificaton of crucial process parameters that are influencing microbial activities will help developing appropriate counter measures against microbial induced clogging and corrosion.

ARC-2006-ACD06-0213-011

NASA Image and Video Library

2006-10-03

Ames and Moffett Field (MFA) historical sites and memorials Unitary Plan Wind Tunned plaza; display and historical site plaques with the NASA logo on the Wind Tunnel valve as a backdrop. shown is the Unitary International Historic Mechanical Engineering Landmark Dedication plaque (American Society of Mechanical Engineers) May 5, 1995

Incorporating the Internet into Traditional Library Instruction.

ERIC Educational Resources Information Center

Fonseca, Tony; King, Monica

2000-01-01

Presents a template for teaching traditional library research and one for incorporating the Web. Highlights include the differences between directories and search engines; devising search strategies; creating search terms; how to choose search engines; evaluating online resources; helpful Web sites; and how to read URLs to evaluate a Web site's…

75 FR 63508 - Warner Chilcott Pharmaceuticals, Inc. Including On-Site Leased Workers From Adecco Engineering...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... Pharmaceuticals, Inc. Including On-Site Leased Workers From Adecco Engineering and Technical, Norwich, New York; Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance In accordance with... a Certification of Eligibility to Apply for Worker Adjustment Assistance on September 10, 2010...

Searching for American Indian Resources on the Internet.

ERIC Educational Resources Information Center

Pollack, Ira; Derby, Amy

This paper provides basic information on searching the Internet and lists World Wide Web sites containing resources for American Indian education. Comprehensive and topical Web directories, search engines, and meta-search engines are briefly described. Search strategies are discussed, and seven Web sites are listed that provide more advanced…

Engineering Ni-Mo-S Nanoparticles for Hydrodesulfurization.

PubMed

Bodin, Anders; Christoffersen, Ann-Louise N; Elkjær, Christian F; Brorson, Michael; Kibsgaard, Jakob; Helveg, Stig; Chorkendorff, Ib

2018-06-13

Nanoparticle engineering for catalytic applications requires both a synthesis technique for the production of well-defined nanoparticles and measurements of their catalytic performance. In this paper, we present a new approach to rationally engineering highly active Ni-Mo-S nanoparticle catalysts for hydrodesulfurization (HDS), i.e., the removal of sulfur from fossil fuels. Nanoparticle catalysts are synthesized by the sputtering of a Mo 75 Ni 25 metal target in a reactive atmosphere of Ar and H 2 S followed by the gas aggregation of the sputtered material into nanoparticles. The nanoparticles are filtered by a quadrupole mass filter and subsequently deposited on a planar substrate, such as a grid for electron microscopy or a microreactor. By varying the mass of the deposited nanoparticles, it is demonstrated that the Ni-Mo-S nanoparticles can be tuned into fullerene-like particles, flat-lying platelets, and upright-oriented platelets. The nanoparticle morphologies provide different abundances of Ni-Mo-S edge sites, which are commonly considered the catalytically important sites. Using a microreactor system, we assess the catalytic activity of the Ni-Mo-S nanoparticles for the HDS of dibenzothiophene. The measurements show that platelets are twice as active as the fullerene-like particles, demonstrating that the Ni-Mo-S edges are more active than basal planes for the HDS. Furthermore, the upright-standing orientation of platelets show an activity that is six times higher than the fullerene-like particles, demonstrating the importance of the edge site number and accessibility to reducing, e.g., sterical hindrance for the reacting molecules.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peck, T; Sparkman, D; Storch, N

''The LLNL Site-Specific Advanced Simulation and Computing (ASCI) Software Quality Engineering Recommended Practices VI.I'' document describes a set of recommended software quality engineering (SQE) practices for ASCI code projects at Lawrence Livermore National Laboratory (LLNL). In this context, SQE is defined as the process of building quality into software products by applying the appropriate guiding principles and management practices. Continual code improvement and ongoing process improvement are expected benefits. Certain practices are recommended, although projects may select the specific activities they wish to improve, and the appropriate time lines for such actions. Additionally, projects can rely on the guidance ofmore » this document when generating ASCI Verification and Validation (VSrV) deliverables. ASCI program managers will gather information about their software engineering practices and improvement. This information can be shared to leverage the best SQE practices among development organizations. It will further be used to ensure the currency and vitality of the recommended practices. This Overview is intended to provide basic information to the LLNL ASCI software management and development staff from the ''LLNL Site-Specific ASCI Software Quality Engineering Recommended Practices VI.I'' document. Additionally the Overview provides steps to using the ''LLNL Site-Specific ASCI Software Quality Engineering Recommended Practices VI.I'' document. For definitions of terminology and acronyms, refer to the Glossary and Acronyms sections in the ''LLNL Site-Specific ASCI Software Quality Engineering Recommended Practices VI.I''.« less

Modeling and analysis of the TF30-P-3 compressor system with inlet pressure distortion

NASA Technical Reports Server (NTRS)

Mazzawy, R. S.; Banks, G. A.

1976-01-01

Circumferential inlet distortion testing of a TF30-P-3 afterburning turbofan engine was conducted at NASA-Lewis Research Center. Pratt and Whitney Aircraft analyzed the data using its multiple segment parallel compressor model and classical compressor theory. Distortion attenuation analysis resulted in a detailed flow field calculation with good agreement between multiple segment model predictions and the test data. Sensitivity of the engine stall line to circumferential inlet distortion was calculated on the basis of parallel compressor theory to be more severe than indicated by the data. However, the calculated stall site location was in agreement with high response instrumentation measurements.

Human Centered Hardware Modeling and Collaboration

NASA Technical Reports Server (NTRS)

Stambolian Damon; Lawrence, Brad; Stelges, Katrine; Henderson, Gena

2013-01-01

In order to collaborate engineering designs among NASA Centers and customers, to in clude hardware and human activities from multiple remote locations, live human-centered modeling and collaboration across several sites has been successfully facilitated by Kennedy Space Center. The focus of this paper includes innovative a pproaches to engineering design analyses and training, along with research being conducted to apply new technologies for tracking, immersing, and evaluating humans as well as rocket, vehic le, component, or faci lity hardware utilizing high resolution cameras, motion tracking, ergonomic analysis, biomedical monitoring, wor k instruction integration, head-mounted displays, and other innovative human-system integration modeling, simulation, and collaboration applications.

Halogenase engineering and its utility in medicinal chemistry.

PubMed

Fraley, Amy E; Sherman, David H

2018-06-15

Halogenation is commonly used in medicinal chemistry to improve the potency of pharmaceutical leads. While synthetic methods for halogenation present selectivity and reactivity challenges, halogenases have evolved over time to perform selective reactions under benign conditions. The optimization of halogenation biocatalysts has utilized enzyme evolution and structure-based engineering alongside biotransformation in a variety of systems to generate stable site-selective variants. The recent improvements in halogenase-catalyzed reactions has demonstrated the utility of these biocatalysts for industrial purposes, and their ability to achieve a broad substrate scope implies a synthetic tractability with increasing relevance in medicinal chemistry. Copyright © 2018 Elsevier Ltd. All rights reserved.

PV output smoothing using a battery and natural gas engine-generator.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Jay Dean; Ellis, Abraham; Denda, Atsushi

2013-02-01

In some situations involving weak grids or high penetration scenarios, the variability of photovoltaic systems can affect the local electrical grid. In order to mitigate destabilizing effects of power fluctuations, an energy storage device or other controllable generation or load can be used. This paper describes the development of a controller for coordinated operation of a small gas engine-generator set (genset) and a battery for smoothing PV plant output. There are a number of benefits derived from using a traditional generation resource in combination with the battery; the variability of the photovoltaic system can be reduced to a specific levelmore » with a smaller battery and Power Conditioning System (PCS) and the lifetime of the battery can be extended. The controller was designed specifically for a PV/energy storage project (Prosperity) and a gas engine-generator (Mesa Del Sol) currently operating on the same feeder in Albuquerque, New Mexico. A number of smoothing simulations of the Prosperity PV were conducted using power data collected from the site. By adjusting the control parameters, tradeoffs between battery use and ramp rates could be tuned. A cost function was created to optimize the control in order to balance, in this example, the need to have low ramp rates with reducing battery size and operation. Simulations were performed for cases with only a genset or battery, and with and without coordinated control between the genset and battery, e.g., without the communication link between sites or during a communication failure. The degree of smoothing without coordinated control did not change significantly because the battery dominated the smoothing response. It is anticipated that this work will be followed by a field demonstration in the near future.« less

Surface Sites for Engineering Allosteric Control in Proteins

PubMed Central

Lee, Jeeyeon; Natarajan, Madhusudan; Nashine, Vishal C.; Socolich, Michael; Vo, Tina; Russ, William P.; Benkovic, Stephen J.; Ranganathan, Rama

2010-01-01

Statistical analyses of protein families reveal networks of coevolving amino acids that functionally link distantly positioned functional surfaces. Such linkages suggest a concept for engineering allosteric control into proteins: The intramolecular networks of two proteins could be joined across their surface sites such that the activity of one protein might control the activity of the other. We tested this idea by creating PAS-DHFR, a designed chimeric protein that connects a light-sensing signaling domain from a plant member of the Per/Arnt/Sim (PAS) family of proteins with Escherichia coli dihydrofolate reductase (DHFR). With no optimization, PAS-DHFR exhibited light-dependent catalytic activity that depended on the site of connection and on known signaling mechanisms in both proteins. PAS-DHFR serves as a proof of concept for engineering regulatory activities into proteins through interface design at conserved allosteric sites. PMID:18927392

Suicide and the Internet: Changes in the accessibility of suicide-related information between 2007 and 2014.

PubMed

Biddle, Lucy; Derges, Jane; Mars, Becky; Heron, Jon; Donovan, Jenny L; Potokar, John; Piper, Martyn; Wyllie, Clare; Gunnell, David

2016-01-15

Following the ongoing concerns about cyber-suicide, we investigate changes between 2007 and 2014 in material likely to be accessed by suicidal individuals searching for methods of suicide. 12 search terms relating to suicide methods were applied to four search engines and the top ten hits from each were categorised and analysed for content. The frequency of each category of site across all searches, using particular search terms and engines, was counted. Key changes: growth of blogs and discussion forums (from 3% of hits, 2007 to 18.5% of hits, 2014); increase in hits linking to general information sites - especially factual sites that detail and evaluate suicide methods (from 9%, 2007 to 21.7%, 2014). Hits for dedicated suicide sites increased (from 19% to 23%), while formal help sites were less visible (from 13% to 6.5%). Overall, 54% of hits contained information about new high-lethality methods. We did not search for help sites so cannot assess the balance of suicide promoting versus preventing sites available online. Social media was beyond the scope of this study. Working with ISPs and search engines would help optimise support sites. Better site moderation and implementation of suicide reporting guidelines should be encouraged. Copyright © 2015 Elsevier B.V. All rights reserved.

Corrective Action Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

K. B. Campbell

This Corrective Action Plan (CAP) provides selected corrective action alternatives and proposes the closure methodology for Corrective Action Unit (CAU) 262, Area 25 Septic Systems and Underground Discharge Point. CAU 262 is identified in the Federal Facility Agreement and Consent Order (FFACO) of 1996. Remediation of CAU 262 is required under the FFACO. CAU 262 is located in Area 25 of the Nevada Test Site (NTS), approximately 100 kilometers (km) (62 miles [mi]) northwest of Las Vegas, Nevada. The nine Corrective Action Sites (CASs) within CAU 262 are located in the Nuclear Rocket Development Station complex. Individual CASs are locatedmore » in the vicinity of the Reactor Maintenance, Assembly, and Disassembly (R-MAD); Engine Maintenance, Assembly, and Disassembly (E-MAD); and Test Cell C compounds. CAU 262 includes the following CASs as provided in the FFACO (1996); CAS 25-02-06, Underground Storage Tank; CAS 25-04-06, Septic Systems A and B; CAS 25-04-07, Septic System; CAS 25-05-03, Leachfield; CAS 25-05-05, Leachfield; CAS 25-05-06, Leachfield; CAS 25-05-08, Radioactive Leachfield; CAS 25-05-12, Leachfield; and CAS 25-51-01, Dry Well. Figures 2, 3, and 4 show the locations of the R-MAD, the E-MAD, and the Test Cell C CASs, respectively. The facilities within CAU 262 supported nuclear rocket reactor engine testing. Activities associated with the program were performed between 1958 and 1973. However, several other projects used the facilities after 1973. A significant quantity of radioactive and sanitary waste was produced during routine operations. Most of the radioactive waste was managed by disposal in the posted leachfields. Sanitary wastes were disposed in sanitary leachfields. Septic tanks, present at sanitary leachfields (i.e., CAS 25-02-06,2504-06 [Septic Systems A and B], 25-04-07, 25-05-05,25-05-12) allowed solids to settle out of suspension prior to entering the leachfield. Posted leachfields do not contain septic tanks. All CASs located in CAU 262 are inactive or abandoned. However, some leachfields may still receive liquids from runoff during storm events. Results from the 2000-2001 site characterization activities conducted by International Technology (IT) Corporation, Las Vegas Office are documented in the Corrective Action Investigation Report for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada. This document is located in Appendix A of the Corrective Action Decision Document for CAU 262. Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada. (DOE/NV, 2001).« less

Installation restoration program. Site investigation report, IRP sites No. 1, No. 2, and No. 3. 106th Civil Engineering Flight, New York Air National Guard, Roslyn Air National Guard Station, Roslyn, New York. Volume 1. Site Investigation report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-11-01

This report presents the results of the Site Investigation (SI) conducted at IRP Sites No. 1, No. 2, and No. 3 at the 106th Civil Engineering Flight (CEF) located at Roslyn Air National Guard Station (ANGS), Roslyn, Long Island, New York. A Preliminary Assessment (PA) (AD-A238 847) of the 106th CEF resulted in the identification of two potentially contaminated waste holding areas and a waste sludge application site. These sites were identified as IRP Site No. 1 (Access Road to Aerospace Ground Equipment `AGE` Shop), IRP Site No. 2 (Old Waste Holding Area No. 1), and IRP Site No. 3more » (Old Waste Holding Area No. 2) and recommended for further investigation under the Installation Restoration Program (IRP).« less

Development of a confined water sensitive urban design (WSUD) system using engineered soils.

PubMed

Dunphy, A; Beecham, S; Vigneswaran, S; Ngo, H H; McLaughlan, R; Collins, A

2007-01-01

Innovative Water Sensitive Urban Design (WSUD) systems are being investigated at three locations to the north and south of Sydney, Australia. These systems contain porous concrete pipes that are designed so that stormwater exfiltrates through the permeable walls of the pipes into the surrounding substrate media material. The porous pipes and media material treat the passing stormwater. The primary aim of the overall project is to develop a model to describe the treatment effectiveness of confined WSUD systems. This paper focuses on the system located at the Weathertex Industrial Site, Heatherbrae. Due to wood processing operations that occur at this site, it is recognised that the surface runoff will carry a heavy organics loading. Granulated Activated Carbon (GAC) is recognised for its ability to reduce the concentration of dissolved organics present in both wastewater and stormwater. GAC was therefore chosen as a filtration medium to be investigated at this site. To maximise the effectiveness of the GAC, extensive laboratory batch studies were undertaken prior to the field system being constructed to determine the optimum GAC/sand ratio. The purpose of the experimental work was to assess the dissolved organic removal potential through sorption of various concentrations of GAC. The aim of this paper is to describe these laboratory experiments and discuss how they related to the field system. Through these experiments it was determined that a sand/GAC ratio of 25:1 was ideal for the media material at the Heatherbrae site.

Thermal power systems, small power systems application project. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Marriott, A. T.

1979-01-01

Current small power system technology as applied to power plants up to 10 MWe in size was assessed. Markets for small power systems were characterized and cost goals were established. Candidate power plant system design concepts were selected for evaluation and preliminary performance and cost assessments were made. Economic studies were conducted and breakeven capital costs were determined for leading contenders among the candidate systems. An application study was made of the potential use of small power systems in providing part of the demand for pumping power by the extensive aqueduct system of California, estimated to be 1000 MWe by 1985. Criteria and methodologies were developed for application to the ranking of candidate power plant system design concepts. Experimental power plants concepts of 1 MWe rating were studied leading toward the definition of a power plant configuration for subsequent detail design, construction, testing and evaluation as Engineering Experiment No. 1 (EE No. 1). Site selection criteria and ground rules for the solicitation of EE No. 1 site participation proposals by DOE were developed.

Extensive goniometric spectral measurements at desert sites for military engineering

NASA Astrophysics Data System (ADS)

Berry, T. E.; Morgan, J. C.; Furey, J. S.; DeMoss, T. A.; Kelley, J. R.; McKenna, J. R.

2012-10-01

Remote-sensing technology designed to exploit disturbed earth signatures has become extremely useful in the detection of disturbed soil in military areas of operation. Soil reflectance can be exploited for this purpose and is dependent on atmospheric conditions. An understanding of the in situ soil background is vital to any type of change detection. Researchers from the Engineering Research and Development Center (ERDC) conducted OCONUS soil spectral measurements at ten sites in Afghanistan from July to November, 2011. Sampling sites were chosen on the basis of geomorphic setting, surface-soil characteristics, and field-expedient conditions. Goniometric spectral measurements at these sites have provided high quality bi-directional reflectance data, and their analyses are presented in the context of threat recognition and discrimination. These data can also provide the basis for BDRF model validation. Most spectral data were acquired under ambient solar lighting, but other data were collected at night and under artificial illumination conditions. Bidirectional measurements of soil reflectance in the VIS/NIR and SWIR were taken using the University of Lethbridge Goniometer System (ULGS) at dawn, mid-day, dusk and after sunset with a light. Soil surface roughness and reflectance varied, depending on the presence of desert varnish and desert pavement at some sites. Sun angle and dust and smoke in the atmosphere impacted soil reflectance and noise in the SWIR part of the light spectrum, in particular. The presence of minerals such as calcium carbonate, gypsum, and oxidized iron in the subsurface directly impacted reflectance measurements in disturbed soil.

Custom-Designed Molecular Scissors for Site-Specific Manipulation of the Plant and Mammalian Genomes

NASA Astrophysics Data System (ADS)

Kandavelou, Karthikeyan; Chandrasegaran, Srinivasan

Zinc finger nucleases (ZFNs) are custom-designed molecular scissors, engineered to cut at specific DNA sequences. ZFNs combine the zinc finger proteins (ZFPs) with the nonspecific cleavage domain of the FokI restriction enzyme. The DNA-binding specificity of ZFNs can be easily altered experimentally. This easy manipulation of the ZFN recognition specificity enables one to deliver a targeted double-strand break (DSB) to a genome. The targeted DSB stimulates local gene targeting by several orders of magnitude at that specific cut site via homologous recombination (HR). Thus, ZFNs have become an important experimental tool to make site-specific and permanent alterations to genomes of not only plants and mammals but also of many other organisms. Engineering of custom ZFNs involves many steps. The first step is to identify a ZFN site at or near the chosen chromosomal target within the genome to which ZFNs will bind and cut. The second step is to design and/or select various ZFP combinations that will bind to the chosen target site with high specificity and affinity. The DNA coding sequence for the designed ZFPs are then assembled by polymerase chain reaction (PCR) using oligonucleotides. The third step is to fuse the ZFP constructs to the FokI cleavage domain. The ZFNs are then expressed as proteins by using the rabbit reticulocyte in vitro transcription/translation system and the protein products assayed for their DNA cleavage specificity.

CRISPR/Cas9-Mediated Mutagenesis of Human Pluripotent Stem Cells in Defined Xeno-Free E8 Medium.

PubMed

Soh, Chew-Li; Huangfu, Danwei

2017-01-01

The recent advent of engineered nucleases including the CRISPR/Cas9 system has greatly facilitated genome manipulation in human pluripotent stem cells (hPSCs). In addition to facilitating hPSC-based disease studies, the application of genome engineering in hPSCs has also opened up new avenues for cell replacement therapy. To improve consistency and reproducibility of hPSC-based studies, and to meet the safety and regulatory requirements for clinical translation, it is necessary to use a defined, xeno-free cell culture system. This chapter describes protocols for CRISPR/Cas9 genome editing in an inducible Cas9 hPSC-based system, using cells cultured in chemically defined, xeno-free E8 Medium on a recombinant human vitronectin substrate. We detail procedures for the design and transfection of CRISPR guide RNAs, colony selection, and the expansion and validation of clonal mutant lines, all within this fully defined culture condition. These methods may be applied to a wide range of genome-engineering applications in hPSCs, including those that utilize different types of site-specific nucleases such as zinc finger nucleases (ZFNs) and TALENs, and form a closer step towards clinical utility of these cells.

Protein organic chemistry and applications for labeling and engineering in live-cell systems.

PubMed

Takaoka, Yousuke; Ojida, Akio; Hamachi, Itaru

2013-04-08

The modification of proteins with synthetic probes is a powerful means of elucidating and engineering the functions of proteins both in vitro and in live cells or in vivo. Herein we review recent progress in chemistry-based protein modification methods and their application in protein engineering, with particular emphasis on the following four strategies: 1) the bioconjugation reactions of amino acids on the surfaces of natural proteins, mainly applied in test-tube settings; 2) the bioorthogonal reactions of proteins with non-natural functional groups; 3) the coupling of recognition and reactive sites using an enzyme or short peptide tag-probe pair for labeling natural amino acids; and 4) ligand-directed labeling chemistries for the selective labeling of endogenous proteins in living systems. Overall, these techniques represent a useful set of tools for application in chemical biology, with the methods 2-4 in particular being applicable to crude (living) habitats. Although still in its infancy, the use of organic chemistry for the manipulation of endogenous proteins, with subsequent applications in living systems, represents a worthy challenge for many chemists. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Challenges and opportunities associated with waste management in India

PubMed Central

Kumar, Sunil; Smith, Stephen R.; Fowler, Geoff; Velis, Costas; Kumar, S. Jyoti; Arya, Shashi; Rena; Kumar, Rakesh

2017-01-01

India faces major environmental challenges associated with waste generation and inadequate waste collection, transport, treatment and disposal. Current systems in India cannot cope with the volumes of waste generated by an increasing urban population, and this impacts on the environment and public health. The challenges and barriers are significant, but so are the opportunities. This paper reports on an international seminar on ‘Sustainable solid waste management for cities: opportunities in South Asian Association for Regional Cooperation (SAARC) countries’ organized by the Council of Scientific and Industrial Research-National Environmental Engineering Research Institute and the Royal Society. A priority is to move from reliance on waste dumps that offer no environmental protection, to waste management systems that retain useful resources within the economy. Waste segregation at source and use of specialized waste processing facilities to separate recyclable materials has a key role. Disposal of residual waste after extraction of material resources needs engineered landfill sites and/or investment in waste-to-energy facilities. The potential for energy generation from landfill via methane extraction or thermal treatment is a major opportunity, but a key barrier is the shortage of qualified engineers and environmental professionals with the experience to deliver improved waste management systems in India. PMID:28405362

Engineer Company Force Structure Force Modularization in Support of Decisive Action. Does the Corps of Engineers Need to Re-Structure Engineer Construction Companies Again in order to Support Decisive Actions?

DTIC Science & Technology

2012-05-16

Regional Command RCP Route Clearance Platoon RSOI Reception, Staging, Onward Movement, Integration SBCT Stryker Brigade Combat Team TOE Table of...Point (ASPs), and field hospital platforms; prepare river crossing sites; and support port repair due to Hydraulic Excavator (HYEX), provides force...platforms, FARPS, supply routes, roads, control points, fire bases, tank ditches, ASPs, and field hospital platforms; prepare river crossing sites; and

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunn, Darrell; Poinssot, Christophe; Begg, Bruce

Management of nuclear waste remains an important international topic that includes reprocessing of commercial nuclear fuel, waste-form design and development, storage and disposal packaging, the process of repository site selection, system design, and performance assessment. Requirements to manage and dispose of materials from the production of nuclear weapons, and the renewed interest in nuclear power, in particular through the Generation IV Forum and the Advanced Fuel Cycle Initiative, can be expected to increase the need for scientific advances in waste management. A broad range of scientific and engineering disciplines is necessary to provide safe and effective solutions and address complexmore » issues. This volume offers an interdisciplinary perspective on materials-related issues associated with nuclear waste management programs. Invited and contributed papers cover a wide range of topics including studies on: spent fuel; performance assessment and models; waste forms for low- and intermediate-level waste; ceramic and glass waste forms for plutonium and high-level waste; radionuclides; containers and engineered barriers; disposal environments and site characteristics; and partitioning and transmutation.« less