Development and evaluation of a suppository formulation containing Lactobacillus and its application in vaginal diseases.

PubMed

Kale, Vinita V; Trivedi, Rashmi V; Wate, Sanjay P; Bhusari, Kishor P

2005-11-01

Lactobacillus has long been considered the protective flora in the vagina that displaces and kills vaginal pathogens. Lactic acid, H2O2, and antibacterial agents such as lactocin and bacitracin produced by Lactobacillus act against the vaginal pathogens. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus. The second objective was to establish its in vivo performance by developing in vitro methods of evaluation. Lyophilized culture of Lactobacillus sporogenes was selected for this study. Three formulations of the suppositories were prepared by the molding method. Formulations I, II, and III contained cocoa butter, glycerinated gelatin, and PEG 1000 base, respectively. The prepared suppositories were characterized for physical properties. Assembly to simulate the application site was designed. Methods to evaluate the viability, production of lactic acid, and H2O2 produced by the released Lactobacillus at the application site were developed and the antagonistic activity was demonstrated. From the physical characteristics of the suppository formulations, the glycerinated gelatin suppository (formulation II) containing lyophilized Lactobacillus was found to be satisfactory. The developed assembly was satisfactory in simulating the application site. The Lactobacillus released was viable and exhibited the production of lactic acid, hydrogen peroxide, and antagonistic activity against the uropathogen. The suppository formulation containing Lactobacillus and the methods of its evaluation were successfully developed in this research work and have several applications in the vaginal diseases of women.

75 FR 68600 - Secretarial India High Technology Business Development Mission; February 6-11, 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

... Government of India (GOI) officially designated two site locations for U.S. commercial nuclear technology.... Applications can be completed on-line at the India High Technology Business Development Mission Web site at... Department of Commerce Secretarial India High Technology Business Development Mission; February 6...

Web Application Design Using Server-Side JavaScript

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hampton, J.; Simons, R.

1999-02-01

This document describes the application design philosophy for the Comprehensive Nuclear Test Ban Treaty Research & Development Web Site. This design incorporates object-oriented techniques to produce a flexible and maintainable system of applications that support the web site. These techniques will be discussed at length along with the issues they address. The overall structure of the applications and their relationships with one another will also be described. The current problems and future design changes will be discussed as well.

Evaluation and application of regional turbidity-sediment regression models in Virginia

USGS Publications Warehouse

Hyer, Kenneth; Jastram, John D.; Moyer, Douglas; Webber, James S.; Chanat, Jeffrey G.

2015-01-01

Conventional thinking has long held that turbidity-sediment surrogate-regression equations are site specific and that regression equations developed at a single monitoring station should not be applied to another station; however, few studies have evaluated this issue in a rigorous manner. If robust regional turbidity-sediment models can be developed successfully, their applications could greatly expand the usage of these methods. Suspended sediment load estimation could occur as soon as flow and turbidity monitoring commence at a site, suspended sediment sampling frequencies for various projects potentially could be reduced, and special-project applications (sediment monitoring following dam removal, for example) could be significantly enhanced. The objective of this effort was to investigate the turbidity-suspended sediment concentration (SSC) relations at all available USGS monitoring sites within Virginia to determine whether meaningful turbidity-sediment regression models can be developed by combining the data from multiple monitoring stations into a single model, known as a “regional” model. Following the development of the regional model, additional objectives included a comparison of predicted SSCs between the regional model and commonly used site-specific models, as well as an evaluation of why specific monitoring stations did not fit the regional model.

Web Platform Application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paulsworth, Ashley; Kurtz, Jim; Brun de Pontet, Stephanie

Sunvestment Energy Group (previously called Sunvestment Group) was established to create a web application that brings together site hosts, those who will obtain the energy from the solar array, with project developers and funders, including affinity investors. Sunvestment Energy Group (SEG) uses a community-based model that engages with investors who have some affinity with the site host organization. In addition to a financial return, these investors receive non-financial value from their investments and are therefore willing to offer lower cost capital. This enables the site host to enjoy more savings from solar through these less expensive Community Power Purchase Agreementsmore » (CPPAs). The purpose of this award was to develop an online platform to bring site hosts and investors together virtually.« less

Robotics Technology Crosscutting Program. Technology summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Robotics Technology Development Program (RTDP) is a needs-driven effort. A length series of presentations and discussions at DOE sites considered critical to DOE`s Environmental Restoration and Waste Management (EM) Programs resulted in a clear understanding of needed robotics applications toward resolving definitive problems at the sites. A detailed analysis of the resulting robotics needs assessment revealed several common threads running through the sites: Tank Waste Retrieval (TWR), Contaminant Analysis Automation (CAA), Mixed Waste Operations (MWO), and Decontamination and Dismantlement (D and D). The RTDP Group also realized that some of the technology development in these four areas had commonmore » (Cross Cutting-CC) needs, for example, computer control and sensor interface protocols. Further, the OTD approach to the Research, Development, Demonstration, Testing, and Evaluation (RDDT and E) process urged an additional organizational breakdown between short-term (1--3 years) and long-term (3--5 years) efforts (Advanced Technology-AT). These factors lead to the formation of the fifth application area for Crosscutting and Advanced Technology (CC and AT) development. The RTDP is thus organized around these application areas -- TWR, CAA, MWO, D and D, and CC and AT -- with the first four developing short-term applied robotics. An RTDP Five-Year Plan was developed for organizing the Program to meet the needs in these application areas.« less

Design, development and evaluation of a tree planting-site-specific fumigant applicator

USDA-ARS?s Scientific Manuscript database

The goal of this research was to use recent advances in the global positioning system (GPS) and computer technology to apply just the right amount of fumigant where it is most needed (i.e., tree-planting-site-specific application) to decrease the incidence of replant disease, and achieve the environ...

Assessment of radioisotope heaters for remote terrestrial applications

NASA Astrophysics Data System (ADS)

Uherka, Kenneth L.

This paper examines the feasibility of using radioisotope byproducts for special heating applications at remote sites in Alaska and other cold regions. The investigation included assessment of candidate radioisotope materials for heater applications, identification of the most promising cold-region applications, evaluation of key technical issues and implementation constraints, and development of conceptual heater designs for candidate applications. Strontium-90 (Sr-90) was selected as the most viable fuel for radioisotopic heaters used in terrestrial applications. Opportunities for the application of radioisotopic heaters were determined through site visits to representative Alaskan installations. Candidate heater applications included water storage tanks, sludge digesters, sewage lagoons, water piping systems, well-head pumping stations, emergency shelters, and fuel storage tank deicers. Radio-isotopic heaters for freeze-up protection of water storage tanks and for enhancement of biological waste treatment processes at remote sites were selected as the most promising applications.

Session: Development and application of guidelines for siting, constructing, operating and monitoring wind turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manville, Albert; Hueckel, Greg

2004-09-01

This session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a discussion/question and answer period. The two papers were: 'Development and Application of USFWS Guidance for Site Evaluation, Siting, Construction, Operation and Monitoring of Wind Turbines' by Albert Manville and 'Wind Power in Washington State' by Greg Hueckel. The session provided a comparison of wind project guidelines developed by the U.S. Fish and Wildlife Service (USFWS) in May 2003 and the Washington State Department of Fish and Wildlife in August 2003. Questions addressed included: is there a need or desire for uniform national or statemore » criteria; can other states learn from Washington State's example, or from the USFWS voluntary guidelines; should there be uniform requirements/guidelines/check-lists for the siting, operation, monitoring, and mitigation to prevent or minimize avian, bat, and other wildlife impacts.« less

A review of European applications of artificial intelligence to space

NASA Technical Reports Server (NTRS)

Drummond, Mark (Editor); Stewart, Helen (Editor)

1993-01-01

The purpose is to describe the applications of Artificial Intelligence (AI) to the European Space program that are being developed or have been developed. The results of a study sponsored by the Artificial Intelligence Research and Development program of NASA's Office of Advanced Concepts and Technology (OACT) are described. The report is divided into two sections. The first consists of site reports, which are descriptions of the AI applications seen at each place visited. The second section consists of two summaries which synthesize the information in the site reports by organizing this information in two different ways. The first organizes the material in terms of the type of application, e.g., data analysis, planning and scheduling, and procedure management. The second organizes the material in terms of the component technologies of Artificial Intelligence which the applications used, e.g., knowledge based systems, model based reasoning, procedural reasoning, etc.

Development, verification, and application of a simplified method to estimate total-streambed scour at bridge sites in Illinois

USGS Publications Warehouse

Holmes, Robert R.; Dunn, Chad J.

1996-01-01

A simplified method to estimate total-streambed scour was developed for application to bridges in the State of Illinois. Scour envelope curves, developed as empirical relations between calculated total scour and bridge-site chracteristics for 213 State highway bridges in Illinois, are used in the method to estimate the 500-year flood scour. These 213 bridges, geographically distributed throughout Illinois, had been previously evaluated for streambed scour with the application of conventional hydraulic and scour-analysis methods recommended by the Federal Highway Administration. The bridge characteristics necessary for application of the simplified bridge scour-analysis method can be obtained from an office review of bridge plans, examination of topographic maps, and reconnaissance-level site inspection. The estimates computed with the simplified method generally resulted in a larger value of 500-year flood total-streambed scour than with the more detailed conventional method. The simplified method was successfully verified with a separate data set of 106 State highway bridges, which are geographically distributed throughout Illinois, and 15 county highway bridges.

78 FR 42775 - CGI Federal, Inc., and Custom Applications Management; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... develop applications, Web sites, Web pages, web-based applications and databases, in accordance with EPA policies and related Federal standards and procedures. The Contractor will provide [[Page 42776

24 CFR 578.25 - Site control.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Site control. 578.25 Section 578.25... COMMUNITY FACILITIES CONTINUUM OF CARE PROGRAM Application and Grant Award Process § 578.25 Site control. (a... has site control within the time frame established in section § 578.21 before HUD will execute a grant...

24 CFR 578.25 - Site control.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Site control. 578.25 Section 578.25... COMMUNITY FACILITIES CONTINUUM OF CARE PROGRAM Application and Grant Award Process § 578.25 Site control. (a... has site control within the time frame established in section § 578.21 before HUD will execute a grant...

System architecture for asynchronous multi-processor robotic control system

NASA Technical Reports Server (NTRS)

Steele, Robert D.; Long, Mark; Backes, Paul

1993-01-01

The architecture for the Modular Telerobot Task Execution System (MOTES) as implemented in the Supervisory Telerobotics (STELER) Laboratory is described. MOTES is the software component of the remote site of a local-remote telerobotic system which is being developed for NASA for space applications, in particular Space Station Freedom applications. The system is being developed to provide control and supervised autonomous control to support both space based operation and ground-remote control with time delay. The local-remote architecture places task planning responsibilities at the local site and task execution responsibilities at the remote site. This separation allows the remote site to be designed to optimize task execution capability within a limited computational environment such as is expected in flight systems. The local site task planning system could be placed on the ground where few computational limitations are expected. MOTES is written in the Ada programming language for a multiprocessor environment.

SITE TECHNOLOGY CAPSULE: GEOTECH DEVELOPMENT CORPORATION COLD TOP EX-SITU VITRIFICATION TECHNOLOGY

EPA Science Inventory

A SITE technology demonstration was conducted in 1997 to evaluate the potential applicability and effectiveness of the Geotech Cold Top ex-situ vitrification technology on chromium-contaminated soils. The primary objective was to develop test data to evaluate whether the waste a...

Evaluation of stormwater harvesting sites using multi criteria decision methodology

NASA Astrophysics Data System (ADS)

Inamdar, P. M.; Sharma, A. K.; Cook, Stephen; Perera, B. J. C.

2018-07-01

Selection of suitable urban stormwater harvesting sites and associated project planning are often complex due to spatial, temporal, economic, environmental and social factors, and related various other variables. This paper is aimed at developing a comprehensive methodology framework for evaluating of stormwater harvesting sites in urban areas using Multi Criteria Decision Analysis (MCDA). At the first phase, framework selects potential stormwater harvesting (SWH) sites using spatial characteristics in a GIS environment. In second phase, MCDA methodology is used for evaluating and ranking of SWH sites in multi-objective and multi-stakeholder environment. The paper briefly describes first phase of framework and focuses chiefly on the second phase of framework. The application of the methodology is also demonstrated over a case study comprising of the local government area, City of Melbourne (CoM), Australia for the benefit of wider water professionals engaged in this area. Nine performance measures (PMs) were identified to characterise the objectives and system performance related to the eight alternative SWH sites for the demonstration of the application of developed methodology. To reflect the stakeholder interests in the current study, four stakeholder participant groups were identified, namely, water authorities (WA), academics (AC), consultants (CS), and councils (CL). The decision analysis methodology broadly consisted of deriving PROMETHEE II rankings of eight alternative SWH sites in the CoM case study, under two distinct group decision making scenarios. The major innovation of this work is the development and application of comprehensive methodology framework that assists in the selection of potential sites for SWH, and facilitates the ranking in multi-objective and multi-stakeholder environment. It is expected that the proposed methodology will assist the water professionals and managers with better knowledge that will reduce the subjectivity in the selection and evaluation of SWH sites.

Application of Geographic Information System and Remotesensing in effective solid waste disposal sites selection in Wukro town, Tigray, Ethiopia

NASA Astrophysics Data System (ADS)

Mohammedshum, A. A.; Gebresilassie, M. A.; Rulinda, C. M.; Kahsay, G. H.; Tesfay, M. S.

2014-11-01

Identifying solid waste disposal sites and appropriately managing them is a challenging task to many developing countries. This is a critical problem too in Ethiopia in general and in Wukro town in particular. The existing site for Wukro town is not sufficient in its capacity and it is damaging the environment due to its location, and the type of waste dumped, while the surrounding area is being irrigated. Due to the swift expansion and urbanization developments in Wukro town, it badly needs to develop controlled solid waste dumping site to prevent several contamination problems. This study was conducted first, to assess the existing waste management strategies in Wukro town; and second, to find out the potential waste disposal sites for the town, using GIS and Remote Sensing techniques. The study exploited the Multi-Criteria Evaluation (MCE) methods to combine necessary factors considered for dumping site selection. The selected method also uses various geographical data including remote sensing data, with GIS spatial analysis tools. Accordingly, site suitability maps for each of the factors were developed in a GIS environment. Results indicate that 12 dumping sites were appropriate and they were further ranked against their suitability in terms of wind direction, proximity to settlement area and distance from the center of the town. Finally, two sites are the best suitable for dumping site. This study indicated that the application of Geographic Information System and Remote Sensing techniques are efficient and low cost tools to study and select appropriate dumping site so as to facilitate decision making processes.

Application of FrontPage 98 to the Development of Web Sites for the Science Division and the Center for the Advancement of Learning and Teaching (CALT) at Anne Arundel Community College.

ERIC Educational Resources Information Center

Bird, Bruce

This paper discusses the development of two World Wide Web sites at Anne Arundel Community College (Maryland). The criteria for the selection of hardware and software for Web site development that led to the decision to use Microsoft FrontPage 98 are described along with its major components and features. The discussion of the Science Division Web…

Using Downhole Probes to Locate and Characterize Buried Transuranic and Mixed Low Level Waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steinman, Donald K; Bramblett, Richard L; Hertzog, Russel C

2012-06-25

Borehole logging probes were developed and tested to locate and quantify transuranic elements in subsurface disposal areas and in contaminated sites at USDOE Weapons Complex sites. A new method of measuring very high levels of chlroine in the subsurface was developed using pulsed neutron technology from oilfield applications. The probes were demonstrated at the Hanford site in wells containing plutonium and other contaminants.

Streamlining Data for Cross-Platform Web Delivery

ERIC Educational Resources Information Center

Watkins, Sean; Battles, Jason; Vacek, Rachel

2013-01-01

Smartphone users expect the presentation of Web sites on their mobile browsers to look and feel like native applications. With the pressure on library Web developers to produce app-like mobile sites, there is often a rush to get a site up without considering the importance of reusing or even restructuring the data driving the Web sites. An…

The application and value of virtual animation in Jinzhai revolutionary site

NASA Astrophysics Data System (ADS)

Liu, Gang; Zhou, Xiaocheng

2017-04-01

A virtual interactive technology in Jinzhai revolutionary site virtual interactive animation, with “Internet plus Jinzhai revolutionary site virtual animation” spread display, to achieve a variety of ways to carry forward the patriotic education, Jinzhai red culture, but also promote benign circulation of red tourism and economic development of Jinzhai revolutionary site protection investment group.

MURMoT. Design and Application of Microbial Uranium Reduction Monitoring Tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loeffler, Frank E.

2014-12-31

Uranium (U) contamination in the subsurface is a major remediation challenge at many DOE sites. Traditional site remedies present enormous costs to DOE; hence, enhanced bioremediation technologies (i.e., biostimulation and bioaugmentation) combined with monitoring efforts are being considered as cost-effective corrective actions to address subsurface contamination. This research effort improved understanding of the microbial U reduction process and developed new tools for monitoring microbial activities. Application of these tools will promote science-based site management decisions that achieve contaminant detoxification, plume control, and long-term stewardship in the most efficient manner. The overarching hypothesis was that the design, validation and application ofmore » a suite of new molecular and biogeochemical tools advance process understanding, and improve environmental monitoring regimes to assess and predict in situ U immobilization. Accomplishments: This project (i) advanced nucleic acid-based approaches to elucidate the presence, abundance, dynamics, spatial distribution, and activity of metal- and radionuclide-detoxifying bacteria; (ii) developed proteomics workflows for detection of metal reduction biomarker proteins in laboratory cultures and contaminated site groundwater; (iii) developed and demonstrated the utility of U isotopic fractionation using high precision mass spectrometry to quantify U(VI) reduction for a range of reduction mechanisms and environmental conditions; and (iv) validated the new tools using field samples from U-contaminated IFRC sites, and demonstrated their prognostic and diagnostic capabilities in guiding decision making for environmental remediation and long-term site stewardship.« less

Development of grid-like applications for public health using Web 2.0 mashup techniques.

PubMed

Scotch, Matthew; Yip, Kevin Y; Cheung, Kei-Hoi

2008-01-01

Development of public health informatics applications often requires the integration of multiple data sources. This process can be challenging due to issues such as different file formats, schemas, naming systems, and having to scrape the content of web pages. A potential solution to these system development challenges is the use of Web 2.0 technologies. In general, Web 2.0 technologies are new internet services that encourage and value information sharing and collaboration among individuals. In this case report, we describe the development and use of Web 2.0 technologies including Yahoo! Pipes within a public health application that integrates animal, human, and temperature data to assess the risk of West Nile Virus (WNV) outbreaks. The results of development and testing suggest that while Web 2.0 applications are reasonable environments for rapid prototyping, they are not mature enough for large-scale public health data applications. The application, in fact a "systems of systems," often failed due to varied timeouts for application response across web sites and services, internal caching errors, and software added to web sites by administrators to manage the load on their servers. In spite of these concerns, the results of this study demonstrate the potential value of grid computing and Web 2.0 approaches in public health informatics.

Iterative performance assessments as a regulatory tool for evaluating repository safety: How experiences from SKI Project-90 were used in formulating the new performance assessment project SITE-94

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andersson, J.

1993-12-31

The Swedish Nuclear Power Inspectorate, SKI, regulatory research program has to prepare for the process of licensing a repository for spent nuclear fuel, by building up the necessary knowledge and review capacity. SKIs main strategy for meeting this demand is to develop an independent performance assessment capability. SKIs first own performance assessment project, Project-90, was completed in 1991 and is now followed by a new project, SITE-94. SITE-94 is based on conclusions reached within Project-90. An independent review of Project-90, carried out by a NEA team of experts, has also contributed to the formation of the project. Another important reasonmore » for the project is that the implementing organization in Sweden, SKB, has proposed to submit an application to start detailed investigation of a repository candidate site around 1997. SITE-94 is a performance assessment of a hypothetical repository at a real site. The main objective of the project is to determine how site specific data should be assimilated into the performance assessment process, and to evaluate how uncertainties inherent in site characterization will influence performance assessment results. This will be addressed by exploring multiple interpretations, conceptual models, and parameters consistent with the site data. The site evaluation will strive for consistency between geological, hydrological, rock mechanical, and geochemical descriptions. Other important elements of SITE-94 are the development of a practical and defensible methodology for defining, constructing and analyzing scenarios, the development of approaches for treatment of uncertainties, evaluation of canister integrity, and the development and application of an appropriate quality assurance plan for performance assessments.« less

Application of remote sensing for prediction and detection of thermal pollution, phase 2

NASA Technical Reports Server (NTRS)

Veziroglu, T. N.; Lee, S. S.

1975-01-01

The development of a predictive mathematical model for thermal pollution in connection with remote sensing measurements was continued. A rigid-lid model has been developed and its application to far-field study has been completed. The velocity and temperature fields have been computed for different atmospheric conditions and for different boundary currents produced by tidal effects. In connection with the theoretical work, six experimental studies of the two sites in question (Biscayne Bay site and Hutchinson Island site) have been carried out. The temperature fields obtained during the tests at the Biscayne Bay site have been compared with the predictions of the rigid-lid model and these results are encouraging. The rigid-lid model is also being applied to near-field study. Preliminary results for a simple case have been obtained and execution of more realistic cases has been initiated. The development of a free-surface model also been initiated. The governing equations have been formulated and the computer programs have been written.

Applicability of aquifer impact models to support decisions at CO 2 sequestration sites

DOE PAGES

Keating, Elizabeth; Bacon, Diana; Carroll, Susan; ...

2016-07-25

The National Risk Assessment Partnership has developed a suite of tools to assess and manage risk at CO 2 sequestration sites. This capability includes polynomial or look-up table based reduced-order models (ROMs) that predict the impact of CO 2 and brine leaks on overlying aquifers. The development of these computationally-efficient models and the underlying reactive transport simulations they emulate has been documented elsewhere (Carroll et al., 2014a; Carroll et al., 2014b; Dai et al., 2014 ; Keating et al., 2016). Here in this paper, we seek to demonstrate applicability of ROM-based analysis by considering what types of decisions and aquifermore » types would benefit from the ROM analysis. We present four hypothetical examples where applying ROMs, in ensemble mode, could support decisions during a geologic CO 2 sequestration project. These decisions pertain to site selection, site characterization, monitoring network evaluation, and health impacts. In all cases, we consider potential brine/CO 2 leak rates at the base of the aquifer to be uncertain. We show that derived probabilities provide information relevant to the decision at hand. Although the ROMs were developed using site-specific data from two aquifers (High Plains and Edwards), the models accept aquifer characteristics as variable inputs and so they may have more broad applicability. We conclude that pH and TDS predictions are the most transferable to other aquifers based on the analysis of the nine water quality metrics (pH, TDS, 4 trace metals, 3 organic compounds). Guidelines are presented for determining the aquifer types for which the ROMs should be applicable.« less

Expert system application for the loading capability assessment of transmission lines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le, T.L.; Negnevitsky, M.; Piekutowski, M.

1995-11-01

This paper describes the application of an expert system for the evaluation of the short time thermal rating and temperature rise of overhead conductors. The expert system has been developed using a database and Leonardo expert system shell which is gaining popularity among commercial tools for developing expert system applications. The expert system has been found to compare well when evaluated against the site tests. A practical application is given to demonstrate the usefulness of the expert system developed.

Production and aerial application of wood shreds as a post-fire hillslope erosion mitigation treatment

Treesearch

Peter R. Robichaud; Louise E. Ashmun; Randy B. Foltz; Charles G. Showers; J. Scott Groenier; Jennifer Kesler; Claire DeLeo; Mary Moore

2013-01-01

Guidelines for the production and aerial application of wood shred mulch as a post-fire hillslope treatment were developed from laboratory and field studies, several field operations, and the evaluations of professionals involved in those operations. At two early trial sites, the wood shred mulch was produced off-site and transported to the area of use. At the 2010...

Integrated ground-water monitoring strategy for NRC-licensed facilities and sites: Case study applications

USGS Publications Warehouse

Price, V.; Temples, T.; Hodges, R.; Dai, Z.; Watkins, D.; Imrich, J.

2007-01-01

This document discusses results of applying the Integrated Ground-Water Monitoring Strategy (the Strategy) to actual waste sites using existing field characterization and monitoring data. The Strategy is a systematic approach to dealing with complex sites. Application of such a systematic approach will reduce uncertainty associated with site analysis, and therefore uncertainty associated with management decisions about a site. The Strategy can be used to guide the development of a ground-water monitoring program or to review an existing one. The sites selected for study fall within a wide range of geologic and climatic settings, waste compositions, and site design characteristics and represent realistic cases that might be encountered by the NRC. No one case study illustrates a comprehensive application of the Strategy using all available site data. Rather, within each case study we focus on certain aspects of the Strategy, to illustrate concepts that can be applied generically to all sites. The test sites selected include:Charleston, South Carolina, Naval Weapons Station,Brookhaven National Laboratory on Long Island, New York,The USGS Amargosa Desert Research Site in Nevada,Rocky Flats in Colorado,C-Area at the Savannah River Site in South Carolina, andThe Hanford 300 Area.A Data Analysis section provides examples of detailed data analysis of monitoring data.

Development of Multimedia Computer Applications for Clinical Pharmacy Training.

ERIC Educational Resources Information Center

Schlict, John R.; Livengood, Bruce; Shepherd, John

1997-01-01

Computer simulations in clinical pharmacy education help expose students to clinical patient management earlier and enable training of large numbers of students outside conventional clinical practice sites. Multimedia instruction and its application to pharmacy training are described, the general process for developing multimedia presentations is…

Development and validation of a weather-based warning system to advise fungicide applications to control dollar spot on turfgrass.

PubMed

Smith, D L; Kerns, J P; Walker, N R; Payne, A F; Horvath, B; Inguagiato, J C; Kaminski, J E; Tomaso-Peterson, M; Koch, P L

2018-01-01

Dollar spot is one of the most common diseases of golf course turfgrass and numerous fungicide applications are often required to provide adequate control. Weather-based disease warning systems have been developed to more accurately time fungicide applications; however, they tend to be ineffective and are not currently in widespread use. The primary objective of this research was to develop a new weather-based disease warning system to more accurately advise fungicide applications to control dollar spot activity across a broad geographic and climactic range. The new dollar spot warning system was developed from data collected at field sites in Madison, WI and Stillwater, OK in 2008 and warning system validation sites were established in Madison, WI, Stillwater, OK, Knoxville, TN, State College, PA, Starkville, MS, and Storrs, CT between 2011 and 2016. A meta-analysis of all site-years was conducted and the most effective warning system for dollar spot development consisted of a five-day moving average of relative humidity and average daily temperature. Using this model the highest effective probability that provided dollar spot control similar to that of a calendar-based program across the numerous sites and years was 20%. Additional analysis found that the 20% spray threshold provided comparable control to the calendar-based program while reducing fungicide usage by up to 30%, though further refinement may be needed as practitioners implement this warning system in a range of environments not tested here. The weather-based dollar spot warning system presented here will likely become an important tool for implementing precision disease management strategies for future turfgrass managers, especially as financial and regulatory pressures increase the need to reduce pesticide usage on golf course turfgrass.

Development and validation of a weather-based warning system to advise fungicide applications to control dollar spot on turfgrass

PubMed Central

Smith, D. L.; Kerns, J. P.; Walker, N. R.; Payne, A. F.; Horvath, B.; Inguagiato, J. C.; Kaminski, J. E.; Tomaso-Peterson, M.

2018-01-01

Dollar spot is one of the most common diseases of golf course turfgrass and numerous fungicide applications are often required to provide adequate control. Weather-based disease warning systems have been developed to more accurately time fungicide applications; however, they tend to be ineffective and are not currently in widespread use. The primary objective of this research was to develop a new weather-based disease warning system to more accurately advise fungicide applications to control dollar spot activity across a broad geographic and climactic range. The new dollar spot warning system was developed from data collected at field sites in Madison, WI and Stillwater, OK in 2008 and warning system validation sites were established in Madison, WI, Stillwater, OK, Knoxville, TN, State College, PA, Starkville, MS, and Storrs, CT between 2011 and 2016. A meta-analysis of all site-years was conducted and the most effective warning system for dollar spot development consisted of a five-day moving average of relative humidity and average daily temperature. Using this model the highest effective probability that provided dollar spot control similar to that of a calendar-based program across the numerous sites and years was 20%. Additional analysis found that the 20% spray threshold provided comparable control to the calendar-based program while reducing fungicide usage by up to 30%, though further refinement may be needed as practitioners implement this warning system in a range of environments not tested here. The weather-based dollar spot warning system presented here will likely become an important tool for implementing precision disease management strategies for future turfgrass managers, especially as financial and regulatory pressures increase the need to reduce pesticide usage on golf course turfgrass. PMID:29522560

Wind turbine siting: A summary of the state of the art

NASA Technical Reports Server (NTRS)

Hiester, T. R.

1982-01-01

The process of siting large wind turbines may be divided into two broad steps: site selection, and site evaluation. Site selection is the process of locating windy sites where wind energy development shows promise of economic viability. Site evaluation is the process of determining in detail for a given site the economic potential of the site. The state of the art in the first aspect of siting, site selection is emphasized. Several techniques for assessing the wind resource were explored or developed in the Federal Wind Energy Program. Local topography and meteorology will determine which of the techniques should be used in locating potential sites. None of the techniques can do the job alone, none are foolproof, and all require considerable knowledge and experience to apply correctly. Therefore, efficient siting requires a strategy which is founded on broad based application of several techniques without relying solely on one narrow field of expertise.

DEVELOPMENT AND APPLICATIONS OF CFD SIMULATIONS IN SUPPORT OF AIR QUALITY STUDIES INVOLVING BUILDINGS

EPA Science Inventory

There is a need to properly develop the application of Computational Fluid Dynamics (CFD) methods in support of air quality studies involving pollution sources near buildings at industrial sites. CFD models are emerging as a promising technology for such assessments, in part due ...

Application of Microtremor Horizontal-to-Vertical Spectral Ratio (MHVSR) Analysis for Site Characterization: State of the Art

NASA Astrophysics Data System (ADS)

Molnar, S.; Cassidy, J. F.; Castellaro, S.; Cornou, C.; Crow, H.; Hunter, J. A.; Matsushima, S.; Sánchez-Sesma, F. J.; Yong, A.

2018-03-01

Nakamura (Q Rep Railway Tech Res Inst 30:25-33, 1989) popularized the application of the horizontal-to-vertical spectral ratio (HVSR) analysis of microtremor (seismic noise or ambient vibration) recordings to estimate the predominant frequency and amplification factor of earthquake shaking. During the following quarter century, popularity in the microtremor HVSR (MHVSR) method grew; studies have verified the stability of a site's MHVSR response over time and validated the MHVSR response with that of earthquake HVSR response. Today, MHVSR analysis is a popular reconnaissance tool used worldwide for seismic microzonation and earthquake site characterization in numerous regions, specifically, in the mapping of site period or fundamental frequency and inverted for shear-wave velocity depth profiles, respectively. However, the ubiquity of MHVSR analysis is predominantly a consequence of its ease in application rather than our full understanding of its theory. We present the state of the art in MHVSR analyses in terms of the development of its theoretical basis, current state of practice, and we comment on its future for applications in earthquake site characterization.

Application of Microtremor Horizontal-to-Vertical Spectral Ratio (MHVSR) Analysis for Site Characterization: State of the Art

NASA Astrophysics Data System (ADS)

Molnar, S.; Cassidy, J. F.; Castellaro, S.; Cornou, C.; Crow, H.; Hunter, J. A.; Matsushima, S.; Sánchez-Sesma, F. J.; Yong, A.

2018-07-01

Nakamura (Q Rep Railway Tech Res Inst 30:25-33, 1989) popularized the application of the horizontal-to-vertical spectral ratio (HVSR) analysis of microtremor (seismic noise or ambient vibration) recordings to estimate the predominant frequency and amplification factor of earthquake shaking. During the following quarter century, popularity in the microtremor HVSR (MHVSR) method grew; studies have verified the stability of a site's MHVSR response over time and validated the MHVSR response with that of earthquake HVSR response. Today, MHVSR analysis is a popular reconnaissance tool used worldwide for seismic microzonation and earthquake site characterization in numerous regions, specifically, in the mapping of site period or fundamental frequency and inverted for shear-wave velocity depth profiles, respectively. However, the ubiquity of MHVSR analysis is predominantly a consequence of its ease in application rather than our full understanding of its theory. We present the state of the art in MHVSR analyses in terms of the development of its theoretical basis, current state of practice, and we comment on its future for applications in earthquake site characterization.

Technology assessment for an integrated PC-based platform for three telemedicine applications

NASA Astrophysics Data System (ADS)

Tohme, Walid G.; Hayes, Wendelin S.; Dai, Hailei L.; Komo, Darmadi; Pahira, John J.; Abernethy, Darrell R.; Rennert, Wolfgang; Kuehl, Karen S.; Hauser, Gabriel J.; Mun, Seong K.

1996-05-01

This paper investigates the design and technical efficacy of an integrated PC based platform for three different medical applications. The technical efficacy of such a telemedicine platform has not been evaluated in the literature and optimal technical requirements have not been developed. The first application, with the Department of Surgery, Division of Urology, tests the utility of a telemedicine platform including radiology images for a surgical stone disease consultation service from an off site location in West Virginia. The second application, with the Department of Internal Medicine, Division of Clinical Pharmacology, investigates the usefulness of telemedicine when used for a clinical pharmacology consultation service from an off-site location. The third application, with the Department of Pediatrics, will test telemedicine for trauma care triage service first within an off-site location in Virginia and then from there to Georgetown University Medical Center.

Development of a Miniature Mass Spectrometer and an Automated Detector for Sampling Explosive Materials

PubMed Central

Hashimoto, Yuichiro

2017-01-01

The development of a robust ionization source using the counter-flow APCI, miniature mass spectrometer, and an automated sampling system for detecting explosives are described. These development efforts using mass spectrometry were made in order to improve the efficiencies of on-site detection in areas such as security, environmental, and industrial applications. A development team, including the author, has struggled for nearly 20 years to enhance the robustness and reduce the size of mass spectrometers to meet the requirements needed for on-site applications. This article focuses on the recent results related to the detection of explosive materials where automated particle sampling using a cyclone concentrator permitted the inspection time to be successfully reduced to 3 s. PMID:28337396

National Stormwater Calculator: Low Impact Development ...

EPA Pesticide Factsheets

The National Stormwater Calculator (NSC) makes it easy to estimate runoff reduction when planning a new development or redevelopment site with low impact development (LID) stormwater controls. The Calculator is currently deployed as a Windows desktop application. The Calculator is organized as a wizard style application that walks the user through the steps necessary to perform runoff calculations on a single urban sub-catchment of 10 acres or less in size. Using an interactive map, the user can select the sub-catchment location and the Calculator automatically acquires hydrologic data for the site.A new LID cost estimation module has been developed for the Calculator. This project involved programming cost curves into the existing Calculator desktop application. The integration of cost components of LID controls into the Calculator increases functionality and will promote greater use of the Calculator as a stormwater management and evaluation tool. The addition of the cost estimation module allows planners and managers to evaluate LID controls based on comparison of project cost estimates and predicted LID control performance. Cost estimation is accomplished based on user-identified size (or auto-sizing based on achieving volume control or treatment of a defined design storm), configuration of the LID control infrastructure, and other key project and site-specific variables, including whether the project is being applied as part of new development or redevelopm

10 CFR 960.1 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Applicability. 960.1 Section 960.1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY General Provisions § 960.1 Applicability. These guidelines were developed in accordance with the...

Do reclamation speed up recovery of soil and soil biota on post mining sites along climatic gradient across continental USA?

NASA Astrophysics Data System (ADS)

Frouz, Jan

2015-04-01

Soil biota community (macrofauna, nematodes and microbial community studied by PLFA) was studied together with soil development in post-mining chronosequences along climatic gradient in the USA, covering hardwood forest (TN, IN), tallgrass prairie (IL), or shortgrass prairie (WY). Post mining sites reclaimed according recent regulation which includes topsoil application and vegetation establishment were compared to local climax. Both young and old restoration sites were much closer to the climax condition in shortgrass prairie than in the other sites. The shortgrass prairie soil community contained abundant root-feeding organisms, which may establish quicker than the saprophagous fauna that was abundant at the other sites. Absence of saprophagous groups, and especially earthworms, resulted in the absence of bioturbation in shortgrass prairie sites while in chronosequences other than the one in shortgrass prairie, bioturbation played an important role in topsoil formation resulting in more complex soil profile development compare to shortgrass prairie. This may contribute to faster recovery communities in shortgrass prairie in comparison with tallgrass prairie and forest as At the same time sites that were reclaimed according recent regulation (topsoil application and vegetation establishment) were compare to unreclaimed sites both about 30 years old in TN IL and WY. It TN soil and soil biota seems to approach fasted to climax in unreclaimed than reclaimed sites. In IL this differences between reclaimed and unreclaimed sites was not so clear. While in WY reclaimed sites seems to approach to climax community fasted than unreclaimed one. This suggests that effect of reclamation vary along climatic gradient. In drier sites, formation of soil matrix from parent material is probably much slower and topsoil application speed up soil community recovery substantially while this effect is less pronounces in more wet sites, where soil compaction due to restoration may in some cases even slow recovery.

Applications of ecological concepts and remote sensing technologies in archaeological site reconnaissance

NASA Technical Reports Server (NTRS)

Miller, W. Frank; Sever, Thomas L.; Lee, C. Daniel

1991-01-01

The concept of integrating ecological perspectives on early man's settlement patterns with advanced remote sensing technologies shows promise for predictive site modeling. Early work with aerial imagery and ecosystem analysis is discussed with respect to the development of a major project in Maya archaeology supported by NASA and the National Geographic Society with technical support from the Mississippi State Remote Sensing Center. A preliminary site reconnaissance model will be developed for testing during the 1991 field season.

Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study.

PubMed

Knolle, Erich; Zadrazil, Markus; Kovacs, Gabor Geza; Medwed, Stephanie; Scharbert, Gisela; Schemper, Michael

2013-12-01

Topical capsaicin 8% was developed for the treatment of peripheral neuropathic pain. The pain reduction is associated with a reversible reduction of epidermal nerve fiber density (ENFD). During its application, topical capsaicin 8% provokes distinct pain. In a randomized, double-blind study analyzed with a block factorial analysis of variance, we tested whether cooling the skin would result in reliable prevention of the application pain without inhibiting reduction of ENFD. A capsaicin 8% patch was cut into 4 quarters and 2 each were applied for 1 hour on the anterior thighs of 12 healthy volunteers. A randomization scheme provided for 1 of the application sites of each thigh to be pretreated with EMLA and the other with placebo, whereas both application sites of 1 thigh, also randomly selected, were cooled by cool packs, resulting in a site temperature of 20°C during the entire treatment period. The maximum pain level given for the cooled sites (visual analogue scale [VAS] 1.3 ± 1.4) proved to be significantly lower than for the non-cooled sites (VAS 7.5 ± 1.9) (P < .0001). In contrast, there was no significant difference in application pain between the sites pretreated with EMLA or with placebo (VAS 4.1 ± 3.6 vs 4.8 ± 3.5, P = .1084). At all application sites, ENFD was significantly reduced by 8.0 ± 2.8 (ENF/mm ± SD, P < .0001), that is, 70%, with no significant differences between the sites with the different experimental conditions. In conclusion, cooling the skin to 20°C reliably prevents the pain from capsaicin 8% patch application, whereas EMLA does not. ENFD reduction is not inhibited by cooling. Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

75 FR 54163 - Notice of Availability: Notice of Funding Availability (NOFA) for the Fiscal Year (FY) 2009...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... the availability on its Web site of the applicant information, submission deadlines, funding criteria... funding for architectural and engineering work, site control, and other planning related expenses that are... using the Department of Housing and Urban Development agency link on the Grants.gov/Find Web site at...

10 CFR 960.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., evaluation, and decision-making activities associated with the process of site screening, site nomination... repository development. Application means the act of making a finding of compliance or noncompliance with the... the process of fracturing and displacement that produces a fault. Favorable condition means a...

Applicability of aquifer impact models to support decisions at CO2 sequestration sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keating, Elizabeth; Bacon, Diana; Carroll, Susan

2016-09-01

The National Risk Assessment Partnership has developed a suite of tools to assess and manage risk at CO2 sequestration sites (www.netldoe.gov/nrap). This capability includes polynomial or look-up table based reduced-order models (ROMs) that predict the impact of CO2 and brine leaks on overlying aquifers. The development of these computationally-efficient models and the underlying reactive transport simulations they emulate has been documented elsewhere (Carroll et al., 2014, Dai et al., 2014, Keating et al., 2015). The ROMs reproduce the ensemble behavior of large numbers of simulations and are well-suited to applications that consider a large number of scenarios to understand parametermore » sensitivity and uncertainty on the risk of CO2 leakage to groundwater quality. In this paper, we seek to demonstrate applicability of ROM-based ensemble analysis by considering what types of decisions and aquifer types would benefit from the ROM analysis. We present four hypothetical four examples where applying ROMs, in ensemble mode, could support decisions in the early stages in a geologic CO2 sequestration project. These decisions pertain to site selection, site characterization, monitoring network evaluation, and health impacts. In all cases, we consider potential brine/CO2 leak rates at the base of the aquifer to be uncertain. We show that derived probabilities provide information relevant to the decision at hand. Although the ROMs were developed using site-specific data from two aquifers (High Plains and Edwards), the models accept aquifer characteristics as variable inputs and so they may have more broad applicability. We conclude that pH and TDS predictions are the most transferable to other aquifers based on the analysis of the nine water quality metrics (pH, TDS, 4 trace metals, 3 organic compounds). Guidelines are presented for determining the aquifer types for which the ROMs should be applicable.« less

2013 strategic petroleum reserve big hill well integrity grading report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lord, David L.; Roberts, Barry L.; Lord, Anna C. Snider

2014-02-01

This report summarizes the work performed in developing a framework for the prioritization of cavern access wells for remediation and monitoring at the Big Hill Strategic Petroleum Reserve site. This framework was then applied to all 28 wells at the Big Hill site with each well receiving a grade for remediation and monitoring. Numerous factors affecting well integrity were incorporated into the grading framework including casing survey results, cavern pressure history, results from geomechanical simulations, and site geologic factors. The framework was developed in a way as to be applicable to all four of the Strategic Petroleum Reserve sites.

Blowing in the wind: evaluating wind energy projects on the national forests

Treesearch

Kerry Schlichting; Evan Mercer

2011-01-01

The 650 million ac of federal lands are facing increased scrutiny for wind energy development. As a result, the US Forest Service has been directed to develop policies and procedures for siting wind energy projects. We incorporate geospatial site suitability analysis with applicable policy and management principles to illustrate the use of a Spatial Decision Support...

76 FR 35460 - Notice of Web Availability: Notice of Funding Availability (NOFA) for HUD's Fiscal Year (FY) 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5500-N-05] Notice of Web Availability...: Notice. SUMMARY: HUD announces the availability on its Web site and Grants.gov , applicant information... Department of Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants...

7 CFR 3560.56 - Processing section 515 housing proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... their non-selection, and the process that may be used to seek a review of the non-selection decision. (d... development costs do not exceed what they would be to purchase and develop an alternative site; (D) The... initial loan applications. The Agency will process initial loan applications in rank order, taking into...

Optimizing Travel Time to Outpatient Interventional Radiology Procedures in a Multi-Site Hospital System Using a Google Maps Application.

PubMed

Mandel, Jacob E; Morel-Ovalle, Louis; Boas, Franz E; Ziv, Etay; Yarmohammadi, Hooman; Deipolyi, Amy; Mohabir, Heeralall R; Erinjeri, Joseph P

2018-02-20

The purpose of this study is to determine whether a custom Google Maps application can optimize site selection when scheduling outpatient interventional radiology (IR) procedures within a multi-site hospital system. The Google Maps for Business Application Programming Interface (API) was used to develop an internal web application that uses real-time traffic data to determine estimated travel time (ETT; minutes) and estimated travel distance (ETD; miles) from a patient's home to each a nearby IR facility in our hospital system. Hypothetical patient home addresses based on the 33 cities comprising our institution's catchment area were used to determine the optimal IR site for hypothetical patients traveling from each city based on real-time traffic conditions. For 10/33 (30%) cities, there was discordance between the optimal IR site based on ETT and the optimal IR site based on ETD at non-rush hour time or rush hour time. By choosing to travel to an IR site based on ETT rather than ETD, patients from discordant cities were predicted to save an average of 7.29 min during non-rush hour (p = 0.03), and 28.80 min during rush hour (p < 0.001). Using a custom Google Maps application to schedule outpatients for IR procedures can effectively reduce patient travel time when more than one location providing IR procedures is available within the same hospital system.

Strategies towards an optimized use of the shallow geothermal potential

NASA Astrophysics Data System (ADS)

Schelenz, S.; Firmbach, L.; Kalbacher, T.; Goerke, U.; Kolditz, O.; Dietrich, P.; Vienken, T.

2013-12-01

Thermal use of the shallow subsurface for heat generation, cooling and thermal energy storage is increasingly gaining importance in reconsideration of future energy supplies, e.g. in the course of German energy transition, with application shifting from isolated to intensive use. The planning and dimensioning of (geo-)thermal applications is strongly influenced by the availability of exploration data. Hence, reliable site-specific dimensioning of systems for the thermal use of the shallow subsurface will contribute to an increase in resource efficiency, cost reduction during installation and operation, as well as reduction of environmental impacts and prevention of resource over-exploitation. Despite large cumulative investments that are being made for the utilization of the shallow thermal potential, thermal energy is in many cases exploited without prior on-site exploration and investigation of the local geothermal potential, due to the lack of adequate and cost-efficient exploration techniques. We will present new strategies for an optimized utilization of urban thermal potential, showcased at a currently developed residential neighborhood with high demand for shallow geothermal applications, based on a) enhanced site characterization and b) simulation of different site specific application scenarios. For enhanced site characterization, surface geophysics and vertical high resolution direct push-profiling were combined for reliable determination of aquifer structure and aquifer parameterization. Based on the site characterization, different site specific geothermal application scenarios, including different system types and system configurations, were simulated using OpenGeoSys to guarantee an environmental and economic sustainable thermal use of the shallow subsurface.

StreamStats in North Carolina: a water-resources Web application

USGS Publications Warehouse

Weaver, J. Curtis; Terziotti, Silvia; Kolb, Katharine R.; Wagner, Chad R.

2012-01-01

A statewide StreamStats application for North Carolina was developed in cooperation with the North Carolina Department of Transportation following completion of a pilot application for the upper French Broad River basin in western North Carolina (Wagner and others, 2009). StreamStats for North Carolina, available at http://water.usgs.gov/osw/streamstats/north_carolina.html, is a Web-based Geographic Information System (GIS) application developed by the U.S. Geological Survey (USGS) in consultation with Environmental Systems Research Institute, Inc. (Esri) to provide access to an assortment of analytical tools that are useful for water-resources planning and management (Ries and others, 2008). The StreamStats application provides an accurate and consistent process that allows users to easily obtain streamflow statistics, basin characteristics, and descriptive information for USGS data-collection sites and user-selected ungaged sites. In the North Carolina application, users can compute 47 basin characteristics and peak-flow frequency statistics (Weaver and others, 2009; Robbins and Pope, 1996) for a delineated drainage basin. Selected streamflow statistics and basin characteristics for data-collection sites have been compiled from published reports and also are immediately accessible by querying individual sites from the web interface. Examples of basin characteristics that can be computed in StreamStats include drainage area, stream slope, mean annual precipitation, and percentage of forested area (Ries and others, 2008). Examples of streamflow statistics that were previously available only through published documents include peak-flow frequency, flow-duration, and precipitation data. These data are valuable for making decisions related to bridge design, floodplain delineation, water-supply permitting, and sustainable stream quality and ecology. The StreamStats application also allows users to identify stream reaches upstream and downstream from user-selected sites and obtain information for locations along streams where activities occur that may affect streamflow conditions. This functionality can be accessed through a map-based interface with the user’s Web browser, or individual functions can be requested remotely through Web services (Ries and others, 2008).

Combining Comprehensive Analysis of Off-Site Lambda Phage Integration with a CRISPR-Based Means of Characterizing Downstream Physiology.

PubMed

Tanouchi, Yu; Covert, Markus W

2017-09-19

During its lysogenic life cycle, the phage genome is integrated into the host chromosome by site-specific recombination. In this report, we analyze lambda phage integration into noncanonical sites using next-generation sequencing and show that it generates significant genetic diversity by targeting over 300 unique sites in the host Escherichia coli genome. Moreover, these integration events can have important phenotypic consequences for the host, including changes in cell motility and increased antibiotic resistance. Importantly, the new technologies that we developed to enable this study-sequencing secondary sites using next-generation sequencing and then selecting relevant lysogens using clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-based selection-are broadly applicable to other phage-bacterium systems. IMPORTANCE Bacteriophages play an important role in bacterial evolution through lysogeny, where the phage genome is integrated into the host chromosome. While phage integration generally occurs at a specific site in the host chromosome, it is also known to occur at other, so-called secondary sites. In this study, we developed a new experimental technology to comprehensively study secondary integration sites and discovered that phage can integrate into over 300 unique sites in the host genome, resulting in significant genetic diversity in bacteria. We further developed an assay to examine the phenotypic consequence of such diverse integration events and found that phage integration can cause changes in evolutionarily relevant traits such as bacterial motility and increases in antibiotic resistance. Importantly, our method is readily applicable to other phage-bacterium systems. Copyright © 2017 Tanouchi and Covert.

Validation testing of a soil macronutrient sensing system

USDA-ARS?s Scientific Manuscript database

Rapid on-site measurements of soil macronutrients (i.e., nitrogen, phosphorus, and potassium) are needed for site-specific crop management, where fertilizer nutrient application rates are adjusted spatially based on local requirements. This study reports on validation testing of a previously develop...

7 CFR 1924.105 - Planning/performing development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... for a specific site. Planning must take into consideration topography, soils, climate, adjacent land... changing demands. All planning and performing development work is the responsibility of the applicant or...

7 CFR 1924.105 - Planning/performing development.

Code of Federal Regulations, 2012 CFR

2012-01-01

... for a specific site. Planning must take into consideration topography, soils, climate, adjacent land... changing demands. All planning and performing development work is the responsibility of the applicant or...

7 CFR 1924.105 - Planning/performing development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... for a specific site. Planning must take into consideration topography, soils, climate, adjacent land... changing demands. All planning and performing development work is the responsibility of the applicant or...

7 CFR 1924.105 - Planning/performing development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... for a specific site. Planning must take into consideration topography, soils, climate, adjacent land... changing demands. All planning and performing development work is the responsibility of the applicant or...

TREATING CHLORINATED WASTES WITH THE KPEG PROCESS

EPA Science Inventory

The two reports summarized here describe development of the alkali metal (polyethylene gylycolate (APEG) chemical technology to dechlorinate hazardous hydrocarbons in soils and its application at four demonstration sites: field-scale application to contaminated soils on the isla...

Distributed analysis functional testing using GangaRobot in the ATLAS experiment

NASA Astrophysics Data System (ADS)

Legger, Federica; ATLAS Collaboration

2011-12-01

Automated distributed analysis tests are necessary to ensure smooth operations of the ATLAS grid resources. The HammerCloud framework allows for easy definition, submission and monitoring of grid test applications. Both functional and stress test applications can be defined in HammerCloud. Stress tests are large-scale tests meant to verify the behaviour of sites under heavy load. Functional tests are light user applications running at each site with high frequency, to ensure that the site functionalities are available at all times. Success or failure rates of these tests jobs are individually monitored. Test definitions and results are stored in a database and made available to users and site administrators through a web interface. In this work we present the recent developments of the GangaRobot framework. GangaRobot monitors the outcome of functional tests, creates a blacklist of sites failing the tests, and exports the results to the ATLAS Site Status Board (SSB) and to the Service Availability Monitor (SAM), providing on the one hand a fast way to identify systematic or temporary site failures, and on the other hand allowing for an effective distribution of the work load on the available resources.

Urban Watershed Forestry Manual Part 3: Urban Tree Planting Guide

Treesearch

Karen Cappiella; Tom Schueler; Tiffany Wright; Jennifer Tomlinson

2006-01-01

This is the third in a three-manual series on using trees to protect and restore urban watersheds. A brief description of each part follows. Part 3. Urban Tree Planting Guide provides detailed guidance on urban tree planting that is applicable at both the development site and the watershed scales. Topics covered include site assessment, planting design, site...

Exploring Middle School Teachers' Perceptions and Applications of a Site-Based, Technology-Related Professional Development Program Focused on Interactive Whiteboards and Classroom Response Systems

ERIC Educational Resources Information Center

Desai, Shreya J.

2012-01-01

This qualitative study examined five middle school teachers' perceptions of a site-based, technology-related professional development (TRPD) program focused on the interactive whiteboard (IWB) and the classroom response system (CRS) and the practices implemented in the teachers' classrooms as a result of participation in the TRPD…

The effect of nitrogen loading on on-site system design: a model for determining land application area size.

PubMed

McCardell, A; Davison, L; Edwards, A

2005-01-01

Designers of on-site wastewater management systems have six opportunities to remove pollutants of concern from the aqueous waste stream before it reaches ground or surface waters. These opportunities occur at source, at point of collection (primary treatment), secondary treatment, tertiary treatment, land application and buffers. This paper presents a computer based model for the sizing of on-site system land application areas applicable to the Lismore area in Northern New South Wales, a region of high rainfall. Inputs to the model include daily climatic data, soil type, number of people loading the system and size of housing allotment. Constraints include allowable phosphorus export, nitrogen export and hydraulic percolation. In the Lismore area nitrogen is the nutrient of most concern. In areas close to environmentally sensitive waterways, and in dense developments, the allowable annual nitrogen export becomes the main factor determining the land application area size. The model offers system designers the opportunity to test various combinations of nitrogen attenuation strategies (source control, secondary treatment) in order to create a solution which offers an acceptable nitrogen export rate while meeting the client's household and financial needs. The model runs on an Excel spreadsheet and has been developed by Lismore City Council.

Technology Diffusion. [SITE 2002 Section].

ERIC Educational Resources Information Center

Niederhauser, Dale S., Ed.; Strudler, Neal, Ed.

This document contains the following papers on technology diffusion from the SITE (Society for Information Technology & Teacher Education) 2002 conference: (1) "Faculty Technology Integration Project" (Comfort Akwaji); (2) "If It Is Broke, Then What?" (D. Lynnwood Belvin and Jennifer Leaderer); (3) "Developing Video-Based E-Learning Applications"…

Development and application of an exchange model for anisotropic water diffusion in the microporous MOF aluminum fumarate

NASA Astrophysics Data System (ADS)

Splith, Tobias; Fröhlich, Dominik; Henninger, Stefan K.; Stallmach, Frank

2018-06-01

Diffusion of water in aluminum fumarate was studied by means of pulsed field gradient (PFG) nuclear magnetic resonance (NMR). Due to water molecules exchanging between the intracrystalline anisotropic pore space and the isotropic intercrystalline void space the model of intracrystalline anisotropic diffusion fails to describe the experimental PFG NMR data at high observation times. Therefore, the two-site exchange model developed by Kärger is extended to the case of exchange between an anisotropic and an isotropic site. This extended exchange model is solved by numerical integration. It describes the experimental data very well and yields values for the intracrystalline diffusion coefficient and the mean residence times of the respective sites. Further PFG NMR studies were performed with coatings consisting of small aluminum fumarate crystals, which are used in adsorptive heat transformation applications. The diffusion coefficients of water in the small crystal coating are compared to the values expected from the extended two-site exchange model and from the model of long-range diffusion.

Who is looking for an internship and successful in obtaining one? Examining application data from REU programs funded through NSF GEO

NASA Astrophysics Data System (ADS)

Hubenthal, M.; Kelly, M.

2017-12-01

The Directorate for Geosciences (GEO) at the National Science Foundation (NSF) is currently funding 60 Research Experiences for Undergraduate (REU) sites. Each site offers opportunities for 8 to 12 undergraduates to participate in research within solid earth, oceans, atmospheric and cryosphere sciences. Because applicant data is collected at individual REU sites, the exact number of unique applicants to all REU sites, and the demographics of this national applicant pool has not been previously reported. While some sites do provide some of this information to NSF in annual reports, obtaining and combining such data is problematic because the percentage of individuals that apply to multiple programs is unknown and generally believed anecdotally to be high, especially for students traditionally underrepresented in the geosciences. Understanding both the scale and makeup of the national applicant pool is important for several reasons. First, very little is known about how the supply and geographic location of slots in REU programs compares to the demand from undergraduate STEM majors interested in research experiences. Second, research into internship programs and their role in the career development process are limited by a lack of baseline data that includes both successful and unsuccessful internship applicants across the various sub-disciplines of the Earth sciences. Finally, designing and refining efforts to engage underrepresented populations in STEM research, and measuring the impact of such efforts is difficult without baseline data for comparison. We will present aggregate application data from up to 20 GEO REU funded programs. These programs represent Oceans, Atmospheres and Earth Science research areas and includes over a thousand applicants. Preliminary analysis suggests the number of unique applicants in the pool is higher than anecdotally predicted. Similarly, unique applicants from underrepresented communities also appears higher than anticipated.

IsoWAN: A NASA Science and Engineering Information and Services Framework

NASA Technical Reports Server (NTRS)

Korsmeyer, David J.; Chow, Edward T.; Conroy, Michael P.; Swanson, Keith (Technical Monitor)

2000-01-01

We believe that the next evolutionary step in supporting wide-area application and services delivery to customers is a network framework that provides for collocation of applications and services at distinct sites in the network, an interconnection between these sites that is performance optimized for these applications, and value-added services for applications. We use the term IsoWAN to describe an advanced, isolated network interconnect services framework that will enable applications to be more secure, and able to access and be in use in both local and remote environments. The main functions of an IsoWAN are virtual localization of application services, an application service interface, coordinated delivery of applications and associated data to the customer, and supporting collaborative application development for customers. An initial pilot network between three NASA Centers: Ames Research Center, the Jet Propulsion Laboratory, and Marshall Space Flight Center, has been built and its properties will be discussed.

7 CFR 4279.261 - Application for loan guarantee content.

Code of Federal Regulations, 2012 CFR

2012-01-01

... project; (2) The viability of such technology for the particular project application; (3) The development... location, size, etc.). Economic feasibility determination. Market feasibility determination. Technical.... Recommendations for implementation. (B) Economic Feasibility: Information regarding project site; Availability of...

78 FR 12748 - Upper Yampa Water Conservancy District; Notice of Application Accepted for Filing, Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... allow commercial development of the site with a marina and restaurant operation that would have elements... the particular application. o. Filing and Service of Documents: Any filing must (1) bear in all...

Statistical and Economic Techniques for Site-specific Nematode Management.

PubMed

Liu, Zheng; Griffin, Terry; Kirkpatrick, Terrence L

2014-03-01

Recent advances in precision agriculture technologies and spatial statistics allow realistic, site-specific estimation of nematode damage to field crops and provide a platform for the site-specific delivery of nematicides within individual fields. This paper reviews the spatial statistical techniques that model correlations among neighboring observations and develop a spatial economic analysis to determine the potential of site-specific nematicide application. The spatial econometric methodology applied in the context of site-specific crop yield response contributes to closing the gap between data analysis and realistic site-specific nematicide recommendations and helps to provide a practical method of site-specifically controlling nematodes.

Cornell University remote sensing program. [application to waste disposal site selection, study of drainage patterns, and water quality management.

NASA Technical Reports Server (NTRS)

Liang, T.; Mcnair, A. J.; Philipson, W. R.

1977-01-01

Aircraft and satellite remote sensing technology were applied in the following areas: (1) evaluation of proposed fly ash disposal sites; (2) development of priorities for drainage improvements; (3) state park analysis for rehabilitation and development; (4) watershed study for water quality planning; and (5) assistance project-landfill site selection. Results are briefly summarized. Other projects conducted include: (1) assessment of vineyard-related problems; (2) LANDSAT analysis for pheasant range management; (3) photo-historic evaluation of Revolutionary War sites; and (4) thermal analysis of building insulation. The objectives, expected benefits and actions, and status of these projects are described.

Environmental restoration and waste management: Robotics technology development program: Robotics 5-year program plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This plan covers robotics Research, Development, Demonstration, Testing and Evaluation activities in the Program for the next five years. These activities range from bench-scale R D to full-scale hot demonstrations at DOE sites. This plan outlines applications of existing technology to near-term needs, the development and application of enhanced technology for longer-term needs, and initiation of advanced technology development to meet those needs beyond the five-year plan. The objective of the Robotic Technology Development Program (RTDP) is to develop and apply robotics technologies that will enable Environmental Restoration and Waste Management (ER WM) operations at DOE sites to be safer,more » faster and cheaper. Five priority DOE sites were visited in March 1990 to identify needs for robotics technology in ER WM operations. This 5-Year Program Plan for the RTDP detailed annual plans for robotics technology development based on identified needs. In July 1990 a forum was held announcing the robotics program. Over 60 organizations (industrial, university, and federal laboratory) made presentations on their robotics capabilities. To stimulate early interactions with the ER WM activities at DOE sites, as well as with the robotics community, the RTDP sponsored four technology demonstrations related to ER WM needs. These demonstrations integrated commercial technology with robotics technology developed by DOE in support of areas such as nuclear reactor maintenance and the civilian reactor waste program. 2 figs.« less

GIS least-cost analysis approach for siting gas pipeline ROWs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.; Wilkey, P.L.

1994-09-01

Geographic-information-system applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation corridors, endangered species habitats, wetlands, and public line surveys. A geographic information system was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas-pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Sentinel site data for model improvement – Definition and characterization

USDA-ARS?s Scientific Manuscript database

Crop models are increasingly being used to assess the impacts of future climate change on production and food security. High quality site-specific data on weather, soils, management, and cultivar are needed for those model applications. Also important, is that model development, evaluation, improvem...

SENSITIVITY ANALYSIS OF THE APPLICATION OF CHEMICAL EXPOSURE CRITERIA FOR COMPARING SITES AND WATERSHEDS

EPA Science Inventory

A methodology was developed for deriving quantitative exposure criteria useful for comparing a site or watershed to a reference condition. The prototype method used indicators of exposures to oil contamination and combustion by-products, naphthalene and benzo(a)pyrene metabolites...

Application of microtremor horizontal-to-vertical spectral ratio (MHVSR) analysis for site characterization: State of the art

USGS Publications Warehouse

Molnar, S.; Cassidy, J. F.; Castellaro, S.; Cornou, C.; Crow, H.; Hunter, J. A.; Matsushima, S.; Sanchez-Sesma, F. J.; Yong, Alan

2018-01-01

Nakamura (Q Rep Railway Tech Res Inst 30:25–33, 1989) popularized the application of the horizontal-to-vertical spectral ratio (HVSR) analysis of microtremor (seismic noise or ambient vibration) recordings to estimate the predominant frequency and amplification factor of earthquake shaking. During the following quarter century, popularity in the microtremor HVSR (MHVSR) method grew; studies have verified the stability of a site’s MHVSR response over time and validated the MHVSR response with that of earthquake HVSR response. Today, MHVSR analysis is a popular reconnaissance tool used worldwide for seismic microzonation and earthquake site characterization in numerous regions, specifically, in the mapping of site period or fundamental frequency and inverted for shear-wave velocity depth profiles, respectively. However, the ubiquity of MHVSR analysis is predominantly a consequence of its ease in application rather than our full understanding of its theory. We present the state of the art in MHVSR analyses in terms of the development of its theoretical basis, current state of practice, and we comment on its future for applications in earthquake site characterization.

Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data.

PubMed

Kamboj, Atul; Hallwirth, Claus V; Alexander, Ian E; McCowage, Geoffrey B; Kramer, Belinda

2017-06-17

The analysis of viral vector genomic integration sites is an important component in assessing the safety and efficiency of patient treatment using gene therapy. Alongside this clinical application, integration site identification is a key step in the genetic mapping of viral elements in mutagenesis screens that aim to elucidate gene function. We have developed a UNIX-based vector integration site analysis pipeline (Ub-ISAP) that utilises a UNIX-based workflow for automated integration site identification and annotation of both single and paired-end sequencing reads. Reads that contain viral sequences of interest are selected and aligned to the host genome, and unique integration sites are then classified as transcription start site-proximal, intragenic or intergenic. Ub-ISAP provides a reliable and efficient pipeline to generate large datasets for assessing the safety and efficiency of integrating vectors in clinical settings, with broader applications in cancer research. Ub-ISAP is available as an open source software package at https://sourceforge.net/projects/ub-isap/ .

Ground Water Issue: Phytoremediation of Contaminated Soil and Ground Water at Hazardous Waste Sites

DTIC Science & Technology

2001-02-01

Development Ground Water Issue Phytoremediation of Contaminated Soil and Ground Water at Hazardous Waste Sites National Risk Management Research... Phytoremediation , the use of plants in remediation, is one such technology. This issue paper focuses on the processes and applications of phytoremediation ...of phytoremediation as a cleanup or containment technique for remediation of hazardous waste sites. Introductory material on plant processes is

Emergence of dominant initiation sites for interictal spikes in rat neocortex

PubMed Central

Vitantonio, Daniel; Xu, Weifeng; Geng, Xinling; Wolff, Brian S.; Takagaki, Kentaroh; Motamedi, Gholam K.

2015-01-01

Neuronal populations with unbalanced inhibition can generate interictal spikes (ISs), where each IS starts from a small initiation site and then spreads activation across a larger area. We used in vivo voltage-sensitive dye imaging to map the initiation site of ISs in rat visual cortex disinhibited by epidural application of bicuculline methiodide. Immediately after the application of bicuculline, the IS initiation sites were widely distributed over the entire disinhibited area. After ∼10 min, a small number of sites became “dominant” and initiated the majority of the ISs throughout the course of imaging. Such domination also occurred in cortical slices, which lack long-range connections between the cortex and subcortical structures. This domination of IS initiation sites may allow timing-related plasticity mechanisms to provide a spatial organization where connections projecting outward from the dominant initiation site become strengthened. Understanding the spatiotemporal organization of IS initiation sites may contribute to our understanding of epileptogenesis in its very early stages, because a dominant IS initiation site with strengthened outward connectivity may ultimately develop into a seizure focus. PMID:26445866

Current status and future directions of precision aerial application for site-specific crop management in the USA

USDA-ARS?s Scientific Manuscript database

The first variable-rate aerial application system was developed about a decade ago in the USA and since then, aerial application has benefitted from these technologies. Many areas of the United States rely on readily available agricultural airplanes or helicopters for pest management, and variable-...

77 FR 40030 - Notice of Availability of Draft Environmental Impact Statement for the Proposed Sierra Vista...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... proposed action and alternatives for development of a large-scale, mixed-use, mixed-density master- planned... applicant group's preferred alternative; (c) Reduced Footprint/Increased Density Alternative; (d) Reduced Footprint/Same Density Alternative; (e) Focused Avoidance Alternative; and (f) Southwest Site, an off site...

ISLLC 2008: Websites to Support Mastery

ERIC Educational Resources Information Center

Follo, Eric; Klocko, Barbara A.

2009-01-01

The author presents here the most comprehensive and applicable list of web sites useful to both education leadership faculty and graduate students who are either practicing school leaders or those aspiring for the principalship. The web sites are based on the Interstate School Leaders Licensure Consortium (ISLLC) Standards recently developed by…

Solar photovoltaics: Stand alone applications. [NASA Lewis Research Center research and development

NASA Technical Reports Server (NTRS)

Deyo, J. N.

1980-01-01

The Lewis Research Center involvement in space photovoltaic research and development and in using photovoltaics for terrestrial applications is described with emphasis on applications in which the normal source of power may be a diesel generator, batteries, or other types of power not connected to a utility grid. Once an application is processed, technology is developed and demonstrated with a user who participates in the cost and furnishes the site. Projects completed related to instruments, communication, refrigeration, and highways, are described as well as warning systems, weather stations, fire lookouts, and village power systems. A commercially available photovoltaic powered electric fence charger is the result of Lewis research and development.

CommServer: A Communications Manager For Remote Data Sites

NASA Astrophysics Data System (ADS)

Irving, K.; Kane, D. L.

2012-12-01

CommServer is a software system that manages making connections to remote data-gathering stations, providing a simple network interface to client applications. The client requests a connection to a site by name, and the server establishes the connection, providing a bidirectional channel between the client and the target site if successful. CommServer was developed to manage networks of FreeWave serial data radios with multiple data sites, repeaters, and network-accessed base stations, and has been in continuous operational use for several years. Support for Iridium modems using RUDICS will be added soon, and no changes to the application interface are anticipated. CommServer is implemented on Linux using programs written in bash shell, Python, Perl, AWK, under a set of conventions we refer to as ThinObject.

Self-reported information needs of anesthesia residency applicants and analysis of applicant-related web sites resources at 131 United States training programs.

PubMed

Chu, Larry F; Young, Chelsea A; Zamora, Abby K; Lowe, Derek; Hoang, Dan B; Pearl, Ronald G; Macario, Alex

2011-02-01

Despite the use of web-based information resources by both anesthesia departments and applicants, little research has been done to assess these resources and determine whether they are meeting applicant needs. Evidence is needed to guide anesthesia informatics research in developing high-quality anesthesia residency program Web sites (ARPWs). We used an anonymous web-based program (SurveyMonkey, Portland, OR) to distribute a survey investigating the information needs and perceived usefulness of ARPWs to all 572 Stanford anesthesia residency program applicants. A quantitative scoring system was then created to assess the quality of ARPWs in meeting the information needs of these applicants. Two researchers independently analyzed all 131 ARPWs in the United States to determine whether the ARPWs met the needs of applicants based on the scoring system. Finally, a qualitative assessment of the overall user experience of ARPWs was developed to account for the subjective elements of the Web site's presentation. Ninety-eight percent of respondents reported having used ARPWs during the application process. Fifty-six percent reported first visiting the Stanford ARPW when deciding whether to apply to Stanford's anesthesia residency program. Multimedia and Web 2.0 technologies were "very" or "most" useful in "learning intangible aspects of a program, like how happy people are" (42% multimedia and Web 2.0 versus 14% text and photos). ARPWs, on average, contained only 46% of the content items identified as important by applicants. The average (SD) quality scores among all ARPWs was 2.06 (0.59) of 4.0 maximum points. The mean overall qualitative score for all 131 ARPWs was 4.97 (1.92) of 10 points. Only 2% of applicants indicated that the majority (75%-100%) of Web sites they visited provided a complete experience. Anesthesia residency applicants rely heavily on ARPWs to research programs, prepare for interviews, and formulate a rank list. Anesthesia departments can improve their ARPWs by including information such as total hours worked and work hours by rotation (missing in 96% and 97% of ARPWs) and providing a valid web address on the Fellowship and Residency Electronic Interactive Database Access System (FREIDA) (missing in 28% of ARPWs).

Terrestrial Environment (Climatic) Criteria Guidelines for Use in Aerospace Vehicle Development, 1973 Revision

NASA Technical Reports Server (NTRS)

Daniels, G. E. (Editor)

1973-01-01

Guidelines are provided on probable climatic extremes and terrestrial environment data applicable to space vehicle and associated equipment design and development. Operational criteria for ground support sites are emphasized.

Use of StreamStats in the Upper French Broad River Basin, North Carolina: A Pilot Water-Resources Web Application

USGS Publications Warehouse

Wagner, Chad R.; Tighe, Kirsten C.; Terziotti, Silvia

2009-01-01

StreamStats is a Web-based Geographic Information System (GIS) application that was developed by the U.S. Geological Survey (USGS) in cooperation with Environmental Systems Research Institute, Inc. (ESRI) to provide access to an assortment of analytical tools that are useful for water-resources planning and management. StreamStats allows users to easily obtain streamflow statistics, basin characteristics, and descriptive information for USGS data-collection sites and selected ungaged sites. StreamStats also allows users to identify stream reaches upstream and downstream from user-selected sites and obtain information for locations along streams where activities occur that can affect streamflow conditions. This functionality can be accessed through a map-based interface with the user's Web browser or through individual functions requested remotely through other Web applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haney, Thomas Jay

This report documents the Data Quality Objectives (DQOs) developed for the Idaho National Laboratory (INL) Site ambient air surveillance program. The development of the DQOs was based on the seven-step process recommended “for systematic planning to generate performance and acceptance criteria for collecting environmental data” (EPA 2006). The process helped to determine the type, quantity, and quality of data needed to meet current regulatory requirements and to follow U.S. Department of Energy guidance for environmental surveillance air monitoring design. It also considered the current air monitoring program that has existed at INL Site since the 1950s. The development of themore » DQOs involved the application of the atmospheric dispersion model CALPUFF to identify likely contamination dispersion patterns at and around the INL Site using site-specific meteorological data. Model simulations were used to quantitatively assess the probable frequency of detection of airborne radionuclides released by INL Site facilities using existing and proposed air monitors.« less

Solar photovoltaics: Stand alone applications

NASA Astrophysics Data System (ADS)

Deyo, J. N.

1980-11-01

The Lewis Research Center involvement in space photovoltaic research and development and in using photovoltaics for terrestrial applications is described with emphasis on applications in which the normal source of power may be a diesel generator, batteries, or other types of power not connected to a utility grid. Once an application is processed, technology is developed and demonstrated with a user who participates in the cost and furnishes the site. Projects completed related to instruments, communication, refrigeration, and highways, are described as well as warning systems, weather stations, fire lookouts, and village power systems. A commercially available photovoltaic powered electric fence charger is the result of Lewis research and development.

Guidelines for model calibration and application to flow simulation in the Death Valley regional groundwater system

USGS Publications Warehouse

Hill, M.C.; D'Agnese, F. A.; Faunt, C.C.

2000-01-01

Fourteen guidelines are described which are intended to produce calibrated groundwater models likely to represent the associated real systems more accurately than typically used methods. The 14 guidelines are discussed in the context of the calibration of a regional groundwater flow model of the Death Valley region in the southwestern United States. This groundwater flow system contains two sites of national significance from which the subsurface transport of contaminants could be or is of concern: Yucca Mountain, which is the potential site of the United States high-level nuclear-waste disposal; and the Nevada Test Site, which contains a number of underground nuclear-testing locations. This application of the guidelines demonstrates how they may be used for model calibration and evaluation, and also to direct further model development and data collection.Fourteen guidelines are described which are intended to produce calibrated groundwater models likely to represent the associated real systems more accurately than typically used methods. The 14 guidelines are discussed in the context of the calibration of a regional groundwater flow model of the Death Valley region in the southwestern United States. This groundwater flow system contains two sites of national significance from which the subsurface transport of contaminants could be or is of concern: Yucca Mountain, which is the potential site of the United States high-level nuclear-waste disposal; and the Nevada Test Site, which contains a number of underground nuclear-testing locations. This application of the guidelines demonstrates how they may be used for model calibration and evaluation, and also to direct further model development and data collection.

Primer on the Implementation of a Pharmacy Intranet Site to Improve Department Communication

PubMed Central

Hale, Holly J.

2013-01-01

Purpose: The purpose of the article is to describe the experience of selecting, developing, and implementing a pharmacy department intranet site with commentary regarding application to other institutions. Clinical practitioners and supporting staff need an effective, efficient, organized, and user-friendly communication tool to utilize and relay information required to optimize patient care. Summary: To create a functional and user-friendly department intranet site, department leadership and staff should be involved in the process from selection of product through implementation. A product that supports both document storage management and communication delivery and has the capability to be customized to provide varied levels of site access is desirable. The designation of an intranet site owner/developer within the department will facilitate purposeful site design and site maintenance execution. A well-designed and up-to-date site along with formal end-user training are essential for staff adoption and continued utilization. Conclusion: Development of a department intranet site requires a considerable time investment by several members of the department. The implementation of an intranet site can be an important step toward achieving improved communications. Staff utilization of this resource is key to its success. PMID:24421523

Primer on the implementation of a pharmacy intranet site to improve department communication.

PubMed

Hale, Holly J

2013-07-01

The purpose of the article is to describe the experience of selecting, developing, and implementing a pharmacy department intranet site with commentary regarding application to other institutions. Clinical practitioners and supporting staff need an effective, efficient, organized, and user-friendly communication tool to utilize and relay information required to optimize patient care. To create a functional and user-friendly department intranet site, department leadership and staff should be involved in the process from selection of product through implementation. A product that supports both document storage management and communication delivery and has the capability to be customized to provide varied levels of site access is desirable. The designation of an intranet site owner/developer within the department will facilitate purposeful site design and site maintenance execution. A well-designed and up-to-date site along with formal end-user training are essential for staff adoption and continued utilization. Development of a department intranet site requires a considerable time investment by several members of the department. The implementation of an intranet site can be an important step toward achieving improved communications. Staff utilization of this resource is key to its success.

Preliminary design of a solar central receiver for site-specific repowering application (Saguaro Power Plant). Volume II. Preliminary design. Final report, October 1982-September 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, E.R.

1983-09-01

The solar central receiver technology, site, and specific unit for repowering were selected in prior analyses and studies. The objectives of this preliminary design study were to: develop a solar central receiver repowering design for Saguaro that (1) has potential to be economically competitive with fossil fueled plants in near and long term applications, (2) has the greatest chance for completion without further government funding, (3) will further define technical and economic feasibility of a 66 MWe gross size plant that is adequate to meet the requirements for utility and industrial process heat applications, (4) can potentially be constructed andmore » operated within the next five years, and (5) incorporates solar central receiver technology and represents state-of-the-art development. This volume on the preliminary design includes the following sections: executive summary; introduction; changes from advanced conceptual design; preliminary design; system characteristics; economic analysis; and development plan.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.; Wilkey, P.L.

1992-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.

1993-10-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for land use/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.; Wilkey, P.L.

1992-01-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Security alarm communication and display systems development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waddoups, I.G.

1990-01-01

Sandia National Laboratories has developed a variety of alarm communication and display systems for a broad spectrum of users. This paper will briefly describe the latest systems developed for the Department of Energy (DOE), the Department of Defense (DoD), and the Department of State (DOS) applications. Applications covered will vary from relatively small facilities to large complex sites. Ongoing system developments will also be discussed. The concluding section will summarize the practical, implementable state-of-the-art features available in new systems. 6 figs.

75 FR 17898 - Foreign-Trade Zone 144-Brunswick, GA; Application for Expansion and Reorganization Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Docket 25-2010] Foreign-Trade Zone 144--Brunswick, GA; Application for Expansion and Reorganization Under Alternative Site Framework An application has been submitted to the Foreign-Trade Zones (FTZ) Board (the Board) by the Brunswick and Glynn County Development Authority, grantee of FTZ 144,...

Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination.

PubMed

Hamilton, Murray G; Hill, Ira; Conley, John; Sawyer, Thomas W; Caneva, Duane C; Lundy, Paul M

2004-11-01

O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) is an extremely toxic organophosphate nerve agent that has been weaponized and stockpiled in a number of different countries, and it has been used in recent terrorist events. It differs from other well-known organophosphate nerve agents in that its primary use is as a contact poison rather than as an inhalation hazard. For this reason, we examined the effects of application site and skin decontamination on VX toxicity in anesthetized domestic swine after topical application. VX applied to the surface of the ear rapidly resulted in signs of toxicity consistent with the development of cholinergic crisis, including apnea and death. VX on the epigastrium resulted in a marked delayed development of toxic signs, reduced toxicity, and reduction in the rate of cholinesterase depression compared with animals exposed on the ear. Skin decontamination (15 minutes post-VX on the ear) arrested the development of clinical signs and prevented further cholinesterase inhibition and death. These results confirm earlier work that demonstrates the importance of exposure site on the resultant toxicity of this agent and they also show that decontamination postexposure has the potential to be an integral and extremely important component of medical countermeasures against this agent.

Discriminative structural approaches for enzyme active-site prediction.

PubMed

Kato, Tsuyoshi; Nagano, Nozomi

2011-02-15

Predicting enzyme active-sites in proteins is an important issue not only for protein sciences but also for a variety of practical applications such as drug design. Because enzyme reaction mechanisms are based on the local structures of enzyme active-sites, various template-based methods that compare local structures in proteins have been developed to date. In comparing such local sites, a simple measurement, RMSD, has been used so far. This paper introduces new machine learning algorithms that refine the similarity/deviation for comparison of local structures. The similarity/deviation is applied to two types of applications, single template analysis and multiple template analysis. In the single template analysis, a single template is used as a query to search proteins for active sites, whereas a protein structure is examined as a query to discover the possible active-sites using a set of templates in the multiple template analysis. This paper experimentally illustrates that the machine learning algorithms effectively improve the similarity/deviation measurements for both the analyses.

Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moy, Franklin J.; Lee, Arthur; Gavrin, Lori Krim

2010-07-23

To aid in the pursuit of selective kinase inhibitors, we have developed a unique ATP site binder tool for the detection of binders outside the ATP site by nuclear magnetic resonance (NMR). We report here the novel synthesis that led to this paramagnetic spin-labeled pyrazolopyrimidine probe (1), which exhibits nanomolar inhibitory activity against multiple kinases. We demonstrate the application of this probe by performing NMR binding experiments with Lck and Src kinases and utilize it to detect the binding of two compounds proximal to the ATP site. The complex structure of the probe with Lck is also presented, revealing howmore » the probe fits in the ATP site and the specific interactions it has with the protein. We believe that this spin-labeled probe is a valuable tool that holds broad applicability in a screen for non-ATP site binders.« less

Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites.

PubMed

Colwill, Karen; Wells, Clark D; Elder, Kelly; Goudreault, Marilyn; Hersi, Kadija; Kulkarni, Sarang; Hardy, W Rod; Pawson, Tony; Morin, Gregg B

2006-03-06

Recombinational systems have been developed to rapidly shuttle Open Reading Frames (ORFs) into multiple expression vectors in order to analyze the large number of cDNAs available in the post-genomic era. In the Creator system, an ORF introduced into a donor vector can be transferred with Cre recombinase to a library of acceptor vectors optimized for different applications. Usability of the Creator system is impacted by the ability to easily manipulate DNA, the number of acceptor vectors for downstream applications, and the level of protein expression from Creator vectors. To date, we have developed over 20 novel acceptor vectors that employ a variety of promoters and epitope tags commonly employed for proteomics applications and gene function analysis. We also made several enhancements to the donor vectors including addition of different multiple cloning sites to allow shuttling from pre-existing vectors and introduction of the lacZ alpha reporter gene to allow for selection. Importantly, in order to ameliorate any effects on protein expression of the loxP site between a 5' tag and ORF, we introduced a splicing event into our expression vectors. The message produced from the resulting 'Creator Splice' vector undergoes splicing in mammalian systems to remove the loxP site. Upon analysis of our Creator Splice constructs, we discovered that protein expression levels were also significantly increased. The development of new donor and acceptor vectors has increased versatility during the cloning process and made this system compatible with a wider variety of downstream applications. The modifications introduced in our Creator Splice system were designed to remove extraneous sequences due to recombination but also aided in downstream analysis by increasing protein expression levels. As a result, we can now employ epitope tags that are detected less efficiently and reduce our assay scale to allow for higher throughput. The Creator Splice system appears to be an extremely useful tool for proteomics.

Modification of the Creator recombination system for proteomics applications – improved expression by addition of splice sites

PubMed Central

Colwill, Karen; Wells, Clark D; Elder, Kelly; Goudreault, Marilyn; Hersi, Kadija; Kulkarni, Sarang; Hardy, W Rod; Pawson, Tony; Morin, Gregg B

2006-01-01

Background Recombinational systems have been developed to rapidly shuttle Open Reading Frames (ORFs) into multiple expression vectors in order to analyze the large number of cDNAs available in the post-genomic era. In the Creator system, an ORF introduced into a donor vector can be transferred with Cre recombinase to a library of acceptor vectors optimized for different applications. Usability of the Creator system is impacted by the ability to easily manipulate DNA, the number of acceptor vectors for downstream applications, and the level of protein expression from Creator vectors. Results To date, we have developed over 20 novel acceptor vectors that employ a variety of promoters and epitope tags commonly employed for proteomics applications and gene function analysis. We also made several enhancements to the donor vectors including addition of different multiple cloning sites to allow shuttling from pre-existing vectors and introduction of the lacZ alpha reporter gene to allow for selection. Importantly, in order to ameliorate any effects on protein expression of the loxP site between a 5' tag and ORF, we introduced a splicing event into our expression vectors. The message produced from the resulting 'Creator Splice' vector undergoes splicing in mammalian systems to remove the loxP site. Upon analysis of our Creator Splice constructs, we discovered that protein expression levels were also significantly increased. Conclusion The development of new donor and acceptor vectors has increased versatility during the cloning process and made this system compatible with a wider variety of downstream applications. The modifications introduced in our Creator Splice system were designed to remove extraneous sequences due to recombination but also aided in downstream analysis by increasing protein expression levels. As a result, we can now employ epitope tags that are detected less efficiently and reduce our assay scale to allow for higher throughput. The Creator Splice system appears to be an extremely useful tool for proteomics. PMID:16519801

Philippine Wind Farm Analysis and Site Selection Analysis, 1 January 2000 - 31 December 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conover, K.

2001-12-01

The U.S. Department of Energy (DOE), through the National Renewable Energy Laboratory (NREL), has been working in partnership with the U.S. Agency for International Development (USAID) in an ongoing process to quantify the Philippine wind energy potential and foster wind farm development. As part of that process, NREL retained Global Energy Concepts, LLC (GEC) to review and update the policy needs as well as develop a site-screening process applicable for the Philippines. GEC worked closely with the Philippines National Power Corporation (NPC) in completing this work. This report provides the results of the policy needs and site selection analyses conductedmore » by GEC.« less

76 FR 49785 - Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Samish Indian...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-11

... alternative, a reduced-intensity development alternative, a non- gaming alternative, and an alternate site... application, determination of the site's eligibility for gaming, compliance with the Clean Water Act, and..., phone number, e-mail address, or other personal identifying information in your comment, you should be...

A general way for quantitative magnetic measurement by transmitted electrons

NASA Astrophysics Data System (ADS)

Song, Dongsheng; Li, Gen; Cai, Jianwang; Zhu, Jing

2016-01-01

EMCD (electron magnetic circular dichroism) technique opens a new door to explore magnetic properties by transmitted electrons. The recently developed site-specific EMCD technique makes it possible to obtain rich magnetic information from the Fe atoms sited at nonequivalent crystallographic planes in NiFe2O4, however it is based on a critical demand for the crystallographic structure of the testing sample. Here, we have further improved and tested the method for quantitative site-specific magnetic measurement applicable for more complex crystallographic structure by using the effective dynamical diffraction effects (general routine for selecting proper diffraction conditions, making use of the asymmetry of dynamical diffraction for design of experimental geometry and quantitative measurement, etc), and taken yttrium iron garnet (Y3Fe5O12, YIG) with more complex crystallographic structure as an example to demonstrate its applicability. As a result, the intrinsic magnetic circular dichroism signals, spin and orbital magnetic moment of iron with site-specific are quantitatively determined. The method will further promote the development of quantitative magnetic measurement with high spatial resolution by transmitted electrons.

National Stormwater Calculator: Low Impact Development ...

EPA Pesticide Factsheets

Stormwater discharges continue to cause impairment of our Nation’s waterbodies. EPA has developed the National Stormwater Calculator (SWC) to help support local, state, and national stormwater management objectives to reduce runoff through infiltration and retention using green infrastructure practices as low impact development (LID) controls. The primary focus of the SWC is to inform site developers on how well they can meet a desired stormwater retention target with and without the use of green infrastructure. It can also be used by landscapers and homeowners. Platform. The SWC is a Windows-based desktop program that requires an internet connection. A mobile web application version that will be compatible with all operating systems is currently being developed and is expected to be released in the fall of 2017.Cost Module. An LID cost estimation module within the application allows planners and managers to evaluate LID controls based on comparison of regional and national project planning level cost estimates (capital and average annual maintenance) and predicted LID control performance. Cost estimation is accomplished based on user-identified size configuration of the LID control infrastructure and other key project and site-specific variables. This includes whether the project is being applied as part of new development or redevelopment and if there are existing site constraints.Climate Scenarios. The SWC allows users to consider how runoff may vary based

NASA Remote Sensing Applications for Archaeology and Cultural Resources Management

NASA Technical Reports Server (NTRS)

Giardino, Marco J.

2008-01-01

NASA's Earth Science Mission Directorate recently completed the deployment of the Earth Observation System (EOS) which is a coordinated series of polar-orbiting and low inclination satellites for long-term global observations of the land surface, biosphere, solid Earth, atmosphere, and oceans. One of the many applications derived from EOS is the advancement of archaeological research and applications. Using satellites, manned and unmanned airborne platform, NASA scientists and their partners have conducted archaeological research using both active and passive sensors. The NASA Stennis Space Center (SSC) located in south Mississippi, near New Orleans, has been a leader in space archaeology since the mid-1970s. Remote sensing is useful in a wide range of archaeological research applications from landscape classification and predictive modeling to site discovery and mapping. Remote sensing technology and image analysis are currently undergoing a profound shift in emphasis from broad classification to detection, identification and condition of specific materials, both organic and inorganic. In the last few years, remote sensing platforms have grown increasingly capable and sophisticated. Sensors currently in use, including commercial instruments, offer significantly improved spatial and spectral resolutions. Paired with new techniques of image analysis, this technology provides for the direct detection of archaeological sites. As in all archaeological research, the application of remote sensing to archaeology requires a priori development of specific research designs and objectives. Initially targeted at broad archaeological issues, NASA space archaeology has progressed toward developing practical applications for cultural resources management (CRM). These efforts culminated with the Biloxi Workshop held by NASA and the University of Mississippi in 2002. The workshop and resulting publication specifically address the requirements of cultural resource managers through the use of remote sensing. In 2007, NASA awarded six competitively chosen projects in Space Archaeology through an open solicitation whose purpose, among several, was to addresses the potential benefits to modern society that can be derived through a better understanding of how past cultures succeeded or failed to adapt to local, regional, and global change. A further objective of NASA's space archaeology is the protection and preservation of cultural heritage sites while planning for the sustainable development of cultural resources. NASA s archaeological approach through remote sensing builds on traditional methods of aerial archaeology (i.e. crop marks) and utilizes advanced technologies for collecting and analyzing archaeological data from digital imagery. NASA s archaeological research and application projects using remote sensing have been conducted throughout the world. In North America, NASA has imaged prehistoric mound sites in Mississippi; prehistoric shell middens in Louisiana, Puebloan sites in New Mexico and more recently the sites associated with the Lewis and Clark Corps of Discovery Expedition (1804-1806). In Central America, NASA archaeologists have researched Mayan sites throughout the region, including the Yucatan and Costa Rica, as well as Olmec localities in Veracruz. Other data has been collected over Angkor, Cambodia, Giza in Egypt, the lost city of Ubar on the Arabian Peninsula.

How economic contexts shape calculations of yield in biodiversity offsetting.

PubMed

Carver, L; Sullivan, S

2017-10-01

We examined and analyzed methods used to create numerical equivalence between sites affected by development and proposed conservation offset sites. Application of biodiversity offsetting metrics in development impact and mitigation assessments is thought to standardize biodiversity conservation outcomes, sometimes termed yield by those conducting these calculations. The youth of biodiversity offsetting in application, however, means little is known about how biodiversity valuations and offset contracts between development and offset sites are agreed on in practice or about long-term conservation outcomes. We examined how sites were made commensurable and how biodiversity gains or yields were calculated and negotiated for a specific offset contract in a government-led pilot study of biodiversity offsets in England. Over 24 months, we conducted participant observations of various stages in the negotiation of offset contracts through repeated visits to 3 (anonymized) biodiversity offset contract sites. We conducted 50 semistructured interviews of stakeholders in regional and local government, the private sector, and civil society. We used a qualitative data analysis software program (DEDOOSE) to textually analyze interview transcriptions. We also compared successive iterations of biodiversity-offsetting calculation spreadsheets and planning documents. A particular focus was the different iterations of a specific biodiversity impact assessment in which the biodiversity offsetting metric developed by the U.K.'s Department for Environment, Food and Rural Affairs was used. We highlight 3 main findings. First, biodiversity offsetting metrics were amended in creative ways as users adapted inputs to metric calculations to balance and negotiate conflicting requirements. Second, the practice of making different habitats equivalent to each other through the application of biodiversity offsetting metrics resulted in commensuration outcomes that may not provide projected conservation gains. Third, the pressure of creating value for money diminished projected conservation yields. © 2017 The Authors. Conservation Biology published by Wiley Periodicals, Inc. on behalf of Society for Conservation Biology.

33 CFR 401.24 - Application for preclearance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Application for preclearance. 401.24 Section 401.24 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION... obtained from the Manager, St. Lambert, Quebec, or downloaded from the St. Lawrence Seaway Web site at http...

Incorporating a Human-Computer Interaction Course into Software Development Curriculums

ERIC Educational Resources Information Center

Janicki, Thomas N.; Cummings, Jeffrey; Healy, R. Joseph

2015-01-01

Individuals have increasing options on retrieving information related to hardware and software. Specific hardware devices include desktops, tablets and smart devices. Also, the number of software applications has significantly increased the user's capability to access data. Software applications include the traditional web site, smart device…

Web 2.0 and Pharmacy Education

PubMed Central

Fox, Brent I.

2009-01-01

New types of social Internet applications (often referred to as Web 2.0) are becoming increasingly popular within higher education environments. Although developed primarily for entertainment and social communication within the general population, applications such as blogs, social video sites, and virtual worlds are being adopted by higher education institutions. These newer applications differ from standard Web sites in that they involve the users in creating and distributing information, hence effectively changing how the Web is used for knowledge generation and dispersion. Although Web 2.0 applications offer exciting new ways to teach, they should not be the core of instructional planning, but rather selected only after learning objectives and instructional strategies have been identified. This paper provides an overview of prominent Web 2.0 applications, explains how they are being used within education environments, and elaborates on some of the potential opportunities and challenges that these applications present. PMID:19960079

Web 2.0 and pharmacy education.

PubMed

Cain, Jeff; Fox, Brent I

2009-11-12

New types of social Internet applications (often referred to as Web 2.0) are becoming increasingly popular within higher education environments. Although developed primarily for entertainment and social communication within the general population, applications such as blogs, social video sites, and virtual worlds are being adopted by higher education institutions. These newer applications differ from standard Web sites in that they involve the users in creating and distributing information, hence effectively changing how the Web is used for knowledge generation and dispersion. Although Web 2.0 applications offer exciting new ways to teach, they should not be the core of instructional planning, but rather selected only after learning objectives and instructional strategies have been identified. This paper provides an overview of prominent Web 2.0 applications, explains how they are being used within education environments, and elaborates on some of the potential opportunities and challenges that these applications present.

A System-Wide Approach to Physician Efficiency and Utilization Rates for Non-Operating Room Anesthesia Sites.

PubMed

Tsai, Mitchell H; Huynh, Tinh T; Breidenstein, Max W; O'Donnell, Stephen E; Ehrenfeld, Jesse M; Urman, Richard D

2017-07-01

There has been little in the development or application of operating room (OR) management metrics to non-operating room anesthesia (NORA) sites. This is in contrast to the well-developed management framework for the OR management. We hypothesized that by adopting the concept of physician efficiency, we could determine the applicability of this clinical productivity benchmark for physicians providing services for NORA cases at a tertiary care center. We conducted a retrospective data analysis of NORA sites at an academic, rural hospital, including both adult and pediatric patients. Using the time stamps from WiseOR® (Palo Alto, CA), we calculated site utilization and physician efficiency for each day. We defined scheduling efficiency (SE) as the number of staffed anesthesiologists divided by the number of staffed sites and stratified the data into three categories (SE < 1, SE = 1, and SE >1). The mean physician efficiency was 0.293 (95% CI, [0.281, 0.305]), and the mean site utilization was 0.328 (95% CI, [0.314, 0.343]). When days were stratified by scheduling efficiency (SE < 1, =1, or >1), we found differences between physician efficiency and site utilization. On days where scheduling efficiency was less than 1, that is, there are more sites than physicians, mean physician efficiency (95% CI, [0.326, 0.402]) was higher than mean site utilization (95% CI, [0.250, 0.296]). We demonstrate that scheduling efficiency vis-à-vis physician efficiency as an OR management metric diverge when anesthesiologists travel between NORA sites. When the opportunity to scale operational efficiencies is limited, increasing scheduling efficiency by incorporating different NORA sites into a "block" allocation on any given day may be the only suitable tactical alternative.

Development and test fuel cell powered on-site integrated total energy systems. Phase 3: Full-scale power plant development

NASA Technical Reports Server (NTRS)

Kaufman, A.

1982-01-01

The on-site system application analysis is summarized. Preparations were completed for the first test of a full-sized single cell. Emphasis of the methanol fuel processor development program shifted toward the use of commercial shell-and-tube heat exchangers. An improved method for predicting the carbon-monoxide tolerance of anode catalysts is described. Other stack support areas reported include improved ABA bipolar plate bonding technology, improved electrical measurement techniques for specification-testing of stack components, and anodic corrosion behavior of carbon materials.

Commonality of Ground Systems in Launch Operations

NASA Technical Reports Server (NTRS)

Quinn, Shawn M.

2008-01-01

NASA is examining the utility of requiring a certain degree of commonality in both flight and ground systems in the Constellation Program. While the benefits of commonality seem obvious in terms of minimizing upfront development and long-term operations and maintenance costs, success in real, large-scale engineering systems used to support launch operations is relatively unknown. A broad literature review conducted for this paper did not yield a single paper specifically addressing the application of commonality for ground systems at any launch site in the United States or abroad. This paper provides a broad overview of the ground systems, captures historical and current application of commonality at the launch site, and offers suggestions for additional research to further develop commonality approaches.

National Stormwater Calculator: Low Impact Development Stormwater Control Cost Estimation Programming & Future Enhancements - Presentation

EPA Science Inventory

The National Stormwater Calculator (NSC) makes it easy to estimate runoff reduction when planning a new development or redevelopment site with low impact development (LID) stormwater controls. The Calculator is currently deployed as a Windows desktop application. The NSC is organ...

National Stormwater Calculator: Low Impact Development Stormwater Control Cost Estimation Programming & Future Enhancements - abstract

EPA Science Inventory

The National Stormwater Calculator (NSC) makes it easy to estimate runoff reduction when planning a new development or redevelopment site with low impact development (LID) stormwater controls. The Calculator is currently deployed as a Windows desktop application. The Calculator i...

76 FR 10403 - Hewlett Packard (HP), Global Product Development, Engineering Workstation Refresh Team, Working...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

...), Global Product Development, Engineering Workstation Refresh Team, Working On-Site at General Motors... groups: The Non-Information Technology Business Development Team, the Engineering Application Support Team, and the Engineering Workstation Refresh Team. On February 2, 2011, the Department issued an...

Report on Lessons Learned from the NP 2010 Early Site Permit Program FINAL REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2008-03-26

This report provides a summary of lessons learned from the demonstration of the licensing process for three Early Site Permit (ESP) applications supported as part of the Department of Energy’s (DOE) Nuclear Power 2010 (NP 2010) program. The ESP process was established by the Nuclear Regulatory Commission (NRC) to enable completion of the site evaluation component of nuclear power plant licensing under 10 CFR Part 52 before a utility makes a decision to build a plant. Early Site Permits are valid for 10 to 20 years and can be renewed for an additional 10 to 20 years. NRC review ofmore » an ESP application addresses site safety issues, environmental protection issues, and plans for coping with emergencies. Successful completion of the ESP process will establish that a site is suitable for possible future construction and operation of a nuclear power plant. Most importantly, an ESP resolves significant site-related safety and environmental issues early in the decision process and helps achieve acceptance by the public. DOE competitively selected Dominion Nuclear Energy North Anna, LLC (Dominion); System Energy Resources, Inc. (an Entergy subsidiary); and Exelon Generation Company, LLC (Exelon) in 2002 to demonstrate the ESP process and provided cost-shared support through the NP 2010 program. Dominion pursued an ESP for the North Anna site in Virginia; System Energy Resources, Inc. pursued an ESP for the Grand Gulf site in Mississippi; and Exelon pursued an ESP for the Clinton site in Illinois. After successfully demonstrating the process, the NRC issued an ESP for Clinton on March 17, 2007; Grand Gulf on April 5, 2007; and North Anna on November 27, 2007. As with all successful projects, there are lessons to be learned from the NP 2010 early site permitting demonstration that can help improve future implementation guidance documents and regulatory review standards. In general, these lessons pertain to the effectiveness of the regulatory process, experience related to guidance for developing and reviewing ESP applications, issues involving ESP plant parameters, and suggestions for future ESP applicants. The development, submittal, and issuance of these first ESPs under DOE’s NP 2010 program started the momentum to exercise NRC’s new 10 CFR Part 52 licensing process. Several key questions that define critical issues regarding the effectiveness of regulations pertaining to ESPs have been identified and summarized in this report. However, the final resolution of whether the ESP component of the Part 52 process significantly contributes to the predictability in nuclear power plant licensing requires more experience and time, such as the completion of the ongoing combined Construction and Operating License (COL) process for the North Anna and Grand Gulf sites. The three ESP project participants prepared and submitted to DOE lessons learned reports from their experience in developing, submitting, and receiving an ESP. This document summarizes these reports, which are appended hereto. The Nuclear Energy Institute (http://www.nei.org/) and NRC (http://www.nrc.gov/) have also prepared reports regarding their perspectives on lessons learned during the ESP process. Their documents can be accessed on their respective web sites. Following is a summary of the lessons learned from the NP 2010 ESP projects. Effectiveness of the ESP Process: In general, the ESP process is expected (subject to demonstration of the ESP finality provisions in the North Anna and Grand Gulf ESPs) to provide high value for applicants as a site banking and risk mitigation strategy. However, several aspects of the initial process, such as NRC hearings and determining an acceptable approach to the NRC’s Emergency Planning requirements, proved challenging for the applicants. Project Execution: Initial regulatory and industry guidance for planning and executing an ESP application program proved to be insufficient to address NRC’s document review expectations. However, continuous communication between NRC and the applicants helped establish an acceptable framework for the applications and resulted in the successful issuance of three ESPs. Still, formal guidance from both NRC and industry is needed for issues involving merchant plants; data collection issues; and interactions between NRC, the public, and the applicants. Specific Plant Parameter Issues: The use of the Plant Parameter Envelope (PPE) approach, when the applicant has not yet chosen a reactor technology, proved to be a major source of confusion between applicants and NRC. This issue had also been a topic of discussion during the NRC ESP hearings. Based upon North Anna and Grand Gulf COLA experiences, the need should be evaluated for future NRC guidance pertaining to the PPE approach to clarify these issues. In addition, NRC, applicants, and industry spent considerable time and resources deciding how to employ new seismic analysis approaches. Future guidance in this area would also be very useful. Best Project Practices: A variety of good practices were identified, such as using specific project tracking and milestone items, handling very large documents electronically, employing a formal and rigorous document review process, and sharing large files across organizational sites. This report also includes a set of general recommendations to assist future ESP applicants. Several recommendations highlight the need for NRC and industry to continue to work together to improve the ESP process.« less

77 FR 74457 - Foreign-Trade Zone 75-Phoenix, Arizona Application for Expansion (New Magnet Site) Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-14

..., Arizona Application for Expansion (New Magnet Site) Under Alternative Site Framework An application has...) adopted by the Board (15 CFR 400.2(c)) to include a new magnet site in Phoenix, Arizona. The application... zone project includes the following magnet sites: Site 1 (338 acres)--within the 550-acre Phoenix Sky...

The Use of Portable Microcomputers to Collect Student and Teacher Behavior Data.

ERIC Educational Resources Information Center

Rieth, Herbert; And Others

1989-01-01

Using portable microcomputers, three applications programs were developed and implemented to collect, store, transmit, and analyze teacher/student observational data. The three applications involved: analyzing teaching behaviors of trainees in field-site placements, using microcomputers to educate mildly handicapped high-school students, and using…

24 CFR 200.72 - Zoning, deed and building restrictions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Zoning, deed and building... Zoning, deed and building restrictions. The project when completed shall not violate any material zoning or deed restrictions applicable to the project site, and shall comply with all applicable building...

Roving Vehicles for Lunar and Planetary Exploration

NASA Technical Reports Server (NTRS)

2004-01-01

This special bibliography includes the design, development, and application of lunar and Mars rovers; vehicle instrumentation and power supplies; navigation and control technologies; and site selection.

77 FR 59890 - Reorganization and Expansion of Foreign-Trade Zone 220 Under Alternative Site Framework; Sioux...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... Foreign-Trade Zone 220 Under Alternative Site Framework; Sioux Falls, SD Pursuant to its authority under... Sioux Falls Development Foundation, grantee of Foreign-Trade Zone 220, submitted an application to the... Dakota, within and adjacent to the Sioux Falls U.S. Customs and Border Protection port of entry, FTZ 220...

The role of data and inference in the development and application of ecological site concepts and state-and-transition models

USDA-ARS?s Scientific Manuscript database

Information embodied in ecological site descriptions and their state-and-transition models is crucial to effective land management, and as such is needed now. There is not time (or money) to employ a traditional research-based approach (i.e., inductive/deductive, hypothesis driven inference) to addr...

Application of airborne remote sensing to the ancient Pompeii site

NASA Astrophysics Data System (ADS)

Vitiello, Fausto; Giordano, Antonio; Borfecchia, Flavio; Martini, Sandro; De Cecco, Luigi

1996-12-01

The ancient Pompeii site is in the Sarno Valley, an area of about 400 km2 in the South of Italy near Naples, that was utilized by man since old time (thousands of years ago). Actually the valley is under critical environmental conditions because of the relevant industrial development. ENEA is conducting various studies and research in the valley. ENEA is employing historical research, ground campaigns, cartography and up-to-date airborne multispectral remote sensing technologies to make a geographical information system. Airborne remote sensing technologies are very suitable for situations as that of the Sarno Valley. The paper describes the archaeological application of the research in progress as regarding the ancient site of Pompeii and its fluvial port.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel F. Ancona III; Kathryn E. George; Richard P. Bowers

This study, supported by the US Department of Energy, Wind Powering America Program, Maryland Department of Natural Resources and Chesapeake Bay Foundation, analyzed barriers to wind energy development in the Mid-Atlantic region along with options for overcoming or mitigating them. The Mid-Atlantic States including Delaware, Maryland, North Carolina and Virginia, have excellent wind energy potential and growing demand for electricity, but only two utility-scale projects have been installed to date. Reasons for this apathetic development of wind resources were analyzed and quantified for four markets. Specific applications are: 1) Appalachian mountain ridgeline sites, 2) on coastal plains and peninsulas, 3)more » at shallow water sites in Delaware and Chesapeake Bays, Albemarle and Pamlico Sounds, and 4) at deeper water sites off the Atlantic coast. Each market has distinctly different opportunities and barriers. The primary barriers to wind development described in this report can be grouped into four categories; state policy and regulatory issues, wind resource technical uncertainty, economic viability, and public interest in environmental issues. The properties of these typologies are not mutually independent and do interact. The report concluded that there are no insurmountable barriers to land-based wind energy projects and they could be economically viable today. Likewise potential sites in sheltered shallow waters in regional bay and sounds have been largely overlooked but could be viable currently. Offshore ocean-based applications face higher costs and technical and wind resource uncertainties. The ongoing research and development program, revision of state incentive policies, additional wind measurement efforts, transmission system expansion, environmental baseline studies and outreach to private developers and stakeholders are needed to reduce barriers to wind energy development.« less

Development and application of a screening model for evaluating bioenhanced dissolution in DNAPL source zones

NASA Astrophysics Data System (ADS)

Phelan, Thomas J.; Abriola, Linda M.; Gibson, Jenny L.; Smits, Kathleen M.; Christ, John A.

2015-12-01

In-situ bioremediation, a widely applied treatment technology for source zones contaminated with dense non-aqueous phase liquids (DNAPLs), has proven economical and reasonably efficient for long-term management of contaminated sites. Successful application of this remedial technology, however, requires an understanding of the complex interaction of transport, mass transfer, and biotransformation processes. The bioenhancement factor, which represents the ratio of DNAPL mass transfer under microbially active conditions to that which would occur under abiotic conditions, is commonly used to quantify the effectiveness of a particular bioremediation remedy. To date, little research has been directed towards the development and validation of methods to predict bioenhancement factors under conditions representative of real sites. This work extends an existing, first-order, bioenhancement factor expression to systems with zero-order and Monod kinetics, representative of many source-zone scenarios. The utility of this model for predicting the bioenhancement factor for previously published laboratory and field experiments is evaluated. This evaluation demonstrates the applicability of these simple bioenhancement factors for preliminary experimental design and analysis, and for assessment of dissolution enhancement in ganglia-contaminated source zones. For ease of application, a set of nomographs is presented that graphically depicts the dependence of bioenhancement factor on physicochemical properties. Application of these nomographs is illustrated using data from a well-documented field site. Results suggest that this approach can successfully capture field-scale, as well as column-scale, behavior. Sensitivity analyses reveal that bioenhanced dissolution will critically depend on in-situ biomass concentrations.

Basics and applications of genome editing technology.

PubMed

Yamamoto, Takashi; Sakamoto, Naoaki

2016-01-01

Genome editing with programmable site-specific nucleases is an emerging technology that enables the manipulation of targeted genes in many organisms and cell lines. Since the development of the CRISPR-Cas9 system in 2012, genome editing has rapidly become an indispensable technology for all life science researchers, applicable in various fields. In this seminar, we will introduce the basics of genome editing and focus on the recent development of genome editing tools and technologies for the modification of various organisms and discuss future directions of the genome editing research field, from basic to medical applications.

Site-selective protein-modification chemistry for basic biology and drug development

NASA Astrophysics Data System (ADS)

Krall, Nikolaus; da Cruz, Filipa P.; Boutureira, Omar; Bernardes, Gonçalo J. L.

2016-02-01

Nature has produced intricate machinery to covalently diversify the structure of proteins after their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a large set of reactions that enable post-expression modification of proteins at pre-determined sites. These reactions are now used to selectively install particular modifications on proteins for many biological and therapeutic applications. For example, they provide an opportunity to install post-translational modifications on proteins to determine their exact biological roles. Labelling of proteins in live cells with fluorescent dyes allows protein uptake and intracellular trafficking to be tracked and also enables physiological parameters to be measured optically. Through the conjugation of potent cytotoxicants to antibodies, novel anti-cancer drugs with improved efficacy and reduced side effects may be obtained. In this Perspective, we highlight the most exciting current and future applications of chemical site-selective protein modification and consider which hurdles still need to be overcome for more widespread use.

Site-selective protein-modification chemistry for basic biology and drug development.

PubMed

Krall, Nikolaus; da Cruz, Filipa P; Boutureira, Omar; Bernardes, Gonçalo J L

2016-02-01

Nature has produced intricate machinery to covalently diversify the structure of proteins after their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a large set of reactions that enable post-expression modification of proteins at pre-determined sites. These reactions are now used to selectively install particular modifications on proteins for many biological and therapeutic applications. For example, they provide an opportunity to install post-translational modifications on proteins to determine their exact biological roles. Labelling of proteins in live cells with fluorescent dyes allows protein uptake and intracellular trafficking to be tracked and also enables physiological parameters to be measured optically. Through the conjugation of potent cytotoxicants to antibodies, novel anti-cancer drugs with improved efficacy and reduced side effects may be obtained. In this Perspective, we highlight the most exciting current and future applications of chemical site-selective protein modification and consider which hurdles still need to be overcome for more widespread use.

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.

PubMed

Boissel, Sandrine; Jarjour, Jordan; Astrakhan, Alexander; Adey, Andrew; Gouble, Agnès; Duchateau, Philippe; Shendure, Jay; Stoddard, Barry L; Certo, Michael T; Baker, David; Scharenberg, Andrew M

2014-02-01

Rare-cleaving endonucleases have emerged as important tools for making targeted genome modifications. While multiple platforms are now available to generate reagents for research applications, each existing platform has significant limitations in one or more of three key properties necessary for therapeutic application: efficiency of cleavage at the desired target site, specificity of cleavage (i.e. rate of cleavage at 'off-target' sites), and efficient/facile means for delivery to desired target cells. Here, we describe the development of a single-chain rare-cleaving nuclease architecture, which we designate 'megaTAL', in which the DNA binding region of a transcription activator-like (TAL) effector is used to 'address' a site-specific meganuclease adjacent to a single desired genomic target site. This architecture allows the generation of extremely active and hyper-specific compact nucleases that are compatible with all current viral and nonviral cell delivery methods.

Is Yucca Mountain a long-term solution for disposing of US spent nuclear fuel and high-level radioactive waste?

PubMed

Thorne, M C

2012-06-01

On 26 January 2012, the Blue Ribbon Commission on America's Nuclear Future released a report addressing, amongst other matters, options for the managing and disposal of high-level waste and spent fuel. The Blue Ribbon Commission was not chartered as a siting commission. Accordingly, it did not evaluate Yucca Mountain or any other location as a potential site for the storage or disposal of spent nuclear fuel and high-level waste. Nevertheless, if the Commission's recommendations are followed, it is clear that any future proposals to develop a repository at Yucca Mountain would require an extended period of consultation with local communities, tribes and the State of Nevada. Furthermore, there would be a need to develop generally applicable regulations for disposal of spent fuel and high-level radioactive waste, so that the Yucca Mountain site could be properly compared with alternative sites that would be expected to be identified in the initial phase of the site-selection process. Based on what is now known of the conditions existing at Yucca Mountain and the large number of safety, environmental and legal issues that have been raised in relation to the DOE Licence Application, it is suggested that it would be imprudent to include Yucca Mountain in a list of candidate sites for future evaluation in a consent-based process for site selection. Even if there were a desire at the local, tribal and state levels to act as hosts for such a repository, there would be enormous difficulties in attempting to develop an adequate post-closure safety case for such a facility, and in showing why this unsaturated environment should be preferred over other geological contexts that exist in the USA and that are more akin to those being studied and developed in other countries.

Continued development of hybrid directional boring technology and New horizontal logging development for characterization, monitoring and instrument emplacement at environmental sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wemple, R.P.; Meyer, R.D.; Jacobson, R.D.

This work in partnership with industry is a continuation of cost- effective innovative, directional boring development begun in FY90 and planed to extend into FY94. Several demonstrations of the strategy of building hybrid hardware from utilities installation, geothermal, and soil mechanics technologies have been performed at Sandia National Laboratories (SNL) and at Charles Machine works (CMW) test sites as well as at a commercial refinery site. Additional tests at the SNL Directional Boring Test Range (DBTR) and a lagoon site are planned in calendar 1991. A new companion project to develop and demonstrate a hybrid capability for horizontal logging withmore » penetrometers, specialty instruments and samplers has been taken from concept to early prototype hardware. The project goal of extending the tracking/locating capability of the shallow boring equipment to 80in. is being pursued with encouraging results at 40in. depths. Boring costs, not including tailored well completions dictated by individual site parameters, are estimated at $20 to $50 per foot. Applications continue to emerge for this work and interest continues to be expressed by DoD and EPA researchers and environmental site engineers. 12 figs.« less

48 CFR 970.2701-1 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... This subpart applies to negotiation of patent rights, rights in technical data provisions and other... sites or facilities, including the conduct of research and development and nuclear weapons production...

BITNET: Past, Present, and Future.

ERIC Educational Resources Information Center

Oberst, Daniel J.; Smith, Sheldon B.

1986-01-01

Discusses history and development of the academic computer network BITNET, including BITNET Network Support Center's growth and services, and international expansion. Network users, reasons for growth, and future developments are reviewed. A BITNET applications sampler and listings of compatible computers and operating systems, sites, and…

The Development of "Water Strider" Inquiry Learning Program for Improving Scientific Inquiry Learning Ability in the Chapter "The Little Creatures World" of the Korea Elementary School 5th Grade Science Textbook

ERIC Educational Resources Information Center

Kim, Dongryeul

2017-01-01

The purpose of this study was to develop a "Water strider" Inquiry Learning Program for improved inquiry learning, and to analyze the validity of the "Water strider." The Inquiry Learning Program's goal was to create an application for finding out an on-site applicability for the "Water strider" Inquiry Learning…

Use of geographic information systems for applications on gas pipeline rights-of-way. Final report, December 1989--December 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, P.J.

1991-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way for this project (ROWs) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1)more » determination of environmentally sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWs; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, P.J.

1991-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way for this project (ROWs) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1)more » determination of environmentally sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWs; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Expanding the Scope of Site-Specific Recombinases for Genetic and Metabolic Engineering

PubMed Central

Gaj, Thomas; Sirk, Shannon J.; Barbas, Carlos F.

2014-01-01

Site-specific recombinases are tremendously valuable tools for basic research and genetic engineering. By promoting high-fidelity DNA modifications, site-specific recombination systems have empowered researchers with unprecedented control over diverse biological functions, enabling countless insights into cellular structure and function. The rigid target specificities of many sites-specific recombinases, however, have limited their adoption in fields that require highly flexible recognition abilities. As a result, intense effort has been directed toward altering the properties of site-specific recombination systems by protein engineering. Here, we review key developments in the rational design and directed molecular evolution of site-specific recombinases, highlighting the numerous applications of these enzymes across diverse fields of study. PMID:23982993

Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis.

PubMed

Enyeart, Peter J; Mohr, Georg; Ellington, Andrew D; Lambowitz, Alan M

2014-01-13

Mobile group II introns are bacterial retrotransposons that combine the activities of an autocatalytic intron RNA (a ribozyme) and an intron-encoded reverse transcriptase to insert site-specifically into DNA. They recognize DNA target sites largely by base pairing of sequences within the intron RNA and achieve high DNA target specificity by using the ribozyme active site to couple correct base pairing to RNA-catalyzed intron integration. Algorithms have been developed to program the DNA target site specificity of several mobile group II introns, allowing them to be made into 'targetrons.' Targetrons function for gene targeting in a wide variety of bacteria and typically integrate at efficiencies high enough to be screened easily by colony PCR, without the need for selectable markers. Targetrons have found wide application in microbiological research, enabling gene targeting and genetic engineering of bacteria that had been intractable to other methods. Recently, a thermostable targetron has been developed for use in bacterial thermophiles, and new methods have been developed for using targetrons to position recombinase recognition sites, enabling large-scale genome-editing operations, such as deletions, inversions, insertions, and 'cut-and-pastes' (that is, translocation of large DNA segments), in a wide range of bacteria at high efficiency. Using targetrons in eukaryotes presents challenges due to the difficulties of nuclear localization and sub-optimal magnesium concentrations, although supplementation with magnesium can increase integration efficiency, and directed evolution is being employed to overcome these barriers. Finally, spurred by new methods for expressing group II intron reverse transcriptases that yield large amounts of highly active protein, thermostable group II intron reverse transcriptases from bacterial thermophiles are being used as research tools for a variety of applications, including qRT-PCR and next-generation RNA sequencing (RNA-seq). The high processivity and fidelity of group II intron reverse transcriptases along with their novel template-switching activity, which can directly link RNA-seq adaptor sequences to cDNAs during reverse transcription, open new approaches for RNA-seq and the identification and profiling of non-coding RNAs, with potentially wide applications in research and biotechnology.

On multi-site damage identification using single-site training data

NASA Astrophysics Data System (ADS)

Barthorpe, R. J.; Manson, G.; Worden, K.

2017-11-01

This paper proposes a methodology for developing multi-site damage location systems for engineering structures that can be trained using single-site damaged state data only. The methodology involves training a sequence of binary classifiers based upon single-site damage data and combining the developed classifiers into a robust multi-class damage locator. In this way, the multi-site damage identification problem may be decomposed into a sequence of binary decisions. In this paper Support Vector Classifiers are adopted as the means of making these binary decisions. The proposed methodology represents an advancement on the state of the art in the field of multi-site damage identification which require either: (1) full damaged state data from single- and multi-site damage cases or (2) the development of a physics-based model to make multi-site model predictions. The potential benefit of the proposed methodology is that a significantly reduced number of recorded damage states may be required in order to train a multi-site damage locator without recourse to physics-based model predictions. In this paper it is first demonstrated that Support Vector Classification represents an appropriate approach to the multi-site damage location problem, with methods for combining binary classifiers discussed. Next, the proposed methodology is demonstrated and evaluated through application to a real engineering structure - a Piper Tomahawk trainer aircraft wing - with its performance compared to classifiers trained using the full damaged-state dataset.

Evaluation of Supplemental Nutrition Assistance Program Education: Application of Behavioral Theory and Survey Validation

ERIC Educational Resources Information Center

Wyker, Brett A.; Jordan, Patricia; Quigley, Danielle L.

2012-01-01

Objective: Application of the Transtheoretical Model (TTM) to Supplemental Nutrition Assistance Program Education (SNAP-Ed) evaluation and development and validation of an evaluation tool used to measure TTM constructs is described. Methods: Surveys were collected from parents of children receiving food at Summer Food Service Program sites prior…

Social media use by orthodontic patients.

PubMed

Henzell, M; Knight, A; Antoun, J S; Farella, M

2013-12-01

Internet-based social media sites have recently surged in popularity and are often used to share thoughts and seek support about health issues. The aim of this study was to investigate how orthodontic patients use Internet-based social media sites to share their treatment-related experiences and attitudes towards braces. A secondary objective was to investigate whether an online or mobile application would be considered helpful in improving co-operation with the use of orthodontic appliances. Patients visiting the orthodontic clinic at the University of Otago were asked to participate in a cross-sectional survey that sought details of their Internet-based social media use and their thoughts about the development of a reminder application. The sample comprised 130 orthodontic patients, with a mean age of 17.2 (SD 6.9) and a nearly equal sex distribution (52.3% were female). Internet-based social media sites were used by 80.8%, with Facebook being the most popular. Some 13.3% of the sample had posted comments about braces on these social media sites. Only 6.7% had considered obtaining information about orthodontic treatment from Internet-based social media sites, with the majority (81%) preferring to seek this information directly from their orthodontist. Nearly two-thirds of those who had difficulty remembering to wear their orthodontic appliances reported that a reminder application on their phone would be beneficial. A large proportion of orthodontic patients use Internet-based social media sites, although only a few currently use them to post about treatment-related topics. Social media sites may provide a useful channel of communication for patients seeking support. Further research is needed to evaluate the use of phone reminder applications in orthodontics.

7 CFR 1948.84 - Application procedure for site development and acquisition grants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Property,” Form FmHA or its successor agency under Public Law 103-354 440-34, (Lease on a site for a public... accordance with 7 CFR part 3550); (3) Description of project and relationship to approved growth management...) Evidence that the land is stable if the land has been previously mined (include relevant data on soil and...

76 FR 5395 - Notice of Availability: Notice of Funding Availability (NOFA) for Fiscal Year (FY) 2010...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-31

... Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm....524. Applications must be submitted electronically through Grants.gov . FOR FURTHER INFORMATION...

76 FR 5188 - Notice of Availability: Notice of Funding Availability (NOFA) for HUD's Fiscal Year (FY) 2010...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm....314. Applications must be submitted electronically through Grants.gov . FOR FURTHER INFORMATION...

75 FR 66384 - Notice of Availability: Notice of Funding Availability (NOFA) for HUD's Fiscal Year 2010 Housing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-28

... Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm/grants/fundsavail.cfm.... Applications must be submitted electronically through Grants.gov . FOR FURTHER INFORMATION CONTACT: Questions...

75 FR 67392 - Notice of Availability: Notice of Funding Availability (NOFA) for HUD's Fiscal Year 2010 Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm... 14.877. Applications must be submitted electronically through Grants.gov . FOR FURTHER INFORMATION...

Brownfield site development -- The Ontario context

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, D.B.

The provincial government of Ontario recently promulgated new guidelines to deal with contamination on sites. One of the purposes of the guideline was to bolster development of contaminated sites by clarifying the regulatory process for redeveloping a contaminated site and to provide several clean-up options based on newer scientific information. These clean-up options include stratified clean-ups and site specific risk based criteria. The applications of the previous guideline were at times cumbersome for industries and land developers which may have impeded development of the Brownfield. This paper compares the changes between the old and the new regulatory clean-up guidelines andmore » presents the differences in approach. This paper also presents the results from interviews with several industries and property developers and assesses their view on the regulatory change as well as their desire to develop Brownfields in Ontario. This information determines if the change in regulatory process has really encouraged development. Results from the interviews with proponents indicated that the new guidelines are a much better approach but still contain barriers such as liability issues. Furthermore, the regulatory approval process has been transferred from the provincial government to the local governments. As a result the local governments are applying the guidelines differently across the province.« less

4R Water Quality Impacts: An Assessment and Synthesis of Forty Years of Drainage Nitrogen Losses.

PubMed

Christianson, L E; Harmel, R D

2015-11-01

The intersection of agricultural drainage and nutrient mobility in the environment has led to multiscale water quality concerns. This work reviewed and quantitatively analyzed nearly 1,000 site-years of subsurface tile drainage nitrogen (N) load data to develop a more comprehensive understanding of the impacts of 4R practices (application of the right source of nutrients, at the right rate and time, and in the right place) within drained landscapes across North America. Using drainage data newly compiled in the "Measured Annual Nutrient loads from AGricultural Environments" (MANAGE) database, relationships were developed across N application rates for nitrate N drainage loads and corn ( L.) yields. The lack of significant differences between N application timing or application method was inconsistent with the current emphasis placed on application timing, in particular, as a water quality improvement strategy ( = 0.934 and 0.916, respectively). Broad-scale analyses such as this can help identify major trends for water quality, but accurate implementation of the 4R approach will require site-specific knowledge to balance agronomic and environmental goals. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

The Long-Term Safety of S-Flurbiprofen Plaster for Osteoarthritis Patients: An Open-Label, 52-Week Study.

PubMed

Yataba, Ikuko; Otsuka, Noboru; Matsushita, Isao; Matsumoto, Hideo; Hoshino, Yuichi

2016-08-01

The newly developed S-flurbiprofen plaster (SFPP) is a tape-type patch that shows innovative percutaneous absorption. This study was designed to evaluate the safety of a long-term 52-week SFPP application to osteoarthritis (OA) patients. This was a multi-center, open-label, uncontrolled prospective study that included 201 OA patients. SFPP at 40 mg/day was applied to the site of pain in 101 patients and at 80 mg/day (2 patches) in 100 patients at a total of 301 sites for 52 weeks. The affected sites assessed included the knee (192), lumbar spine (66), cervical spine (26), and others (17). Drug safety was evaluated by medical examination, laboratory tests, and examination of vital signs. Efficacy was evaluated by the patient's and clinician's global assessments and clinical symptoms. Most patients (80.1 %) completed the 52-week SFPP application. The majority of drug-related adverse events (AEs) included mild dermatitis at the application sites and occurred in 46.8 % of the sites. No photosensitive dermatitis was observed. Systemic AEs occurred in 9.0 % of the patients; a serious AE (gastric ulcer hemorrhage) occurred in one patient. No clinically significant changes in the laboratory tests and vital signs were observed. The efficacy evaluation showed an improvement from 2 weeks after the SFPP application, which continued during the 52 weeks' treatment. No apparent safety concerns were observed, even during the long-term SFPP application. Therefore, SFPP could be an additional pharmacotherapy in OA treatment.

Ultrabroadband photonic internet: safety aspects

NASA Astrophysics Data System (ADS)

Kalicki, Arkadiusz; Romaniuk, Ryszard

2008-11-01

Web applications became most popular medium in the Internet. Popularity, easiness of web application frameworks together with careless development results in high number of vulnerabilities and attacks. There are several types of attacks possible because of improper input validation. SQL injection is ability to execute arbitrary SQL queries in a database through an existing application. Cross-site scripting is the vulnerability which allows malicious web users to inject code into the web pages viewed by other users. Cross-Site Request Forgery (CSRF) is an attack that tricks the victim into loading a page that contains malicious request. Web spam in blogs. There are several techniques to mitigate attacks. Most important are web application strong design, correct input validation, defined data types for each field and parameterized statements in SQL queries. Server hardening with firewall, modern security policies systems and safe web framework interpreter configuration are essential. It is advised to keep proper security level on client side, keep updated software and install personal web firewalls or IDS/IPS systems. Good habits are logging out from services just after finishing work and using even separate web browser for most important sites, like e-banking.

APPLICATION ANALYSIS REPORT: HORSEHEAD RESOURCE DEVELOPMENT COMPANY INC., FLAME REACTOR TECHNOLOGY

EPA Science Inventory

A SITE demonstration of the Horsehead Resource Development (HRD) company, Inc. Flame Reactor Technology was conducted in March 1991 at the HRD facility in Monaca, Pennsylvania. For this demonstration, secondary lead smelter soda slag was treated to produce a potentially recyclabl...

ESRI applications of GIS technology: Mineral resource development

NASA Technical Reports Server (NTRS)

Derrenbacher, W.

1981-01-01

The application of geographic information systems technology to large scale regional assessment related to mineral resource development, identifying candidate sites for related industry, and evaluating sites for waste disposal is discussed. Efforts to develop data bases were conducted at scales ranging from 1:3,000,000 to 1:25,000. In several instances, broad screening was conducted for large areas at a very general scale with more detailed studies subsequently undertaken in promising areas windowed out of the generalized data base. Increasingly, the systems which are developed are structured as the spatial framework for the long-term collection, storage, referencing, and retrieval of vast amounts of data about large regions. Typically, the reconnaissance data base for a large region is structured at 1:250,000 scale, data bases for smaller areas being structured at 1:25,000, 1:50,000 or 1:63,360. An integrated data base for the coterminous US was implemented at a scale of 1:3,000,000 for two separate efforts.

Virtual Diving in the Underwater Archaeological Site of Cala Minnola

NASA Astrophysics Data System (ADS)

Bruno, F.; Lagudi, A.; Barbieri, L.; Muzzupappa, M.; Mangeruga, M.; Pupo, F.; Cozza, M.; Cozza, A.; Ritacco, G.; Peluso, R.; Tusa, S.

2017-02-01

The paper presents the application of the technologies and methods defined in the VISAS project for the case study of the underwater archaeological site of Cala Minnola located in the island of Levanzo, in the archipelago of the Aegadian Islands (Sicily, Italy). The VISAS project (http://visas-project.eu) aims to improve the responsible and sustainable exploitation of the Underwater Cultural Heritage by means the development of new methods and technologies including an innovative virtual tour of the submerged archaeological sites. In particular, the paper describes the 3D reconstruction of the underwater archaeological site of Cala Minnola and focus on the development of the virtual scene for its visualization and exploitation. The virtual dive of the underwater archaeological site allows users to live a recreational and educational experience by receiving historical, archaeological and biological information about the submerged exhibits, the flora and fauna of the place.

Introduction to Soil Fumigant Management Plans

EPA Pesticide Factsheets

Soil fumigant pesticide labels require users to prepare a site-specific fumigation management plan (FMP) before the application begins. EPA has developed templates that outline the elements required by the labels.

Developable Images Produced by X-rays Using the Nickel Hypophosphite System. 1 X-ray Sensitive Salts

NASA Technical Reports Server (NTRS)

May, C. E.; Philipp, W. H.; Marsik, S. J.

1972-01-01

Twenty-eight crystalline salts were X-irradiated and treated with an ammoniacal nickel hypophosphite solution. Treatment (development) of six of the salts resulted in precipitation of nickel metal. The developable salts were four hypophosphites, sodium phosphite, and nickel formate. A mechanism is proposed for the process based on the postulate that micro amounts of hydrogen atoms are formed during the radiation step. During development, these hydrogen atoms cause the formation of nucleation sites of nickel metal. In turn, these sites catalyze further reduction of the nickel cations by the hypophosphite. The results are discussed in terms of application of the process to the formation of developable latent images.

Evaluating an Exterior Insulation and Finish System for Deep Energy Retrofits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dentz, Jordan; Podorson, David

Exterior insulation and finish systems (EIFS) are proprietary synthetic formulations that are applied to the exterior walls of buildings to serve as insulation and exterior cladding. The insulation thickness can vary from less than one inch to a foot or more. In this project the applicability of EIFS for residential deep energy retrofits was investigated through modeling and a case study home. The home was retrofitted using a site-applied four-inch-thick EIFS. Site-specific details were developed as required for the residential retrofit application. Site work and the costs of the EIFS system were documented. The demonstration home was modeled using Buildingmore » Energy Optimization energy and cost analysis software to explore cost effectiveness of various EIFS insulation thicknesses in two climate locations.« less

Development of concepts for low-cost energy storage assemblies for annual cycle energy system applications

NASA Astrophysics Data System (ADS)

Alexander, G. H.; Cooper, D. L.; Cummings, C. A.; Reiber, E. E.

1981-10-01

Low cost energy storage assemblies were developed. In the search for low overall cost assemblies, many diverse concepts and materials were postulated and briefly evaluated. Cost rankings, descriptions, and discussions of the concepts were presented from which ORNL selected the following three concepts for the Phase 2 development: (1) a site constructed tank with reinforced concrete walls formed with specialized modular blocks which eliminates most concrete form work and provides integral R-20 insulation designated ORNLFF; (2) a site constructed tank with earth supported walls that are formed from elements common to residential, in-ground swimming pools, designated SWPL; (3) and a site assembled tank used in underground utility vaults, designated UTLBX. Detailed designs of free standing versions of the three concepts are presented.

Development of an open-path gas analyser for plume detection in security applications

NASA Astrophysics Data System (ADS)

Hay, Kenneth G.; Norberg, Ola; Normand, Erwan; Önnerud, Hans; Black, Paul

2017-04-01

We present here an open-path analyser, initially intended for security applications, specifically for the detection of gas plumes from illicit improvised explosive device (IED) manufacturing. Subsequently, the analysers were adapted for methane measurement and used to investigate its applicability for leak detection in different scenarios (e.g. unconventional gas extraction sites). Preliminary results showed consistent measurements of gas plumes in the open path.

Applications of CRISPR/Cas9 technology for targeted mutagenesis, gene replacement and stacking of genes in higher plants.

PubMed

Luo, Ming; Gilbert, Brian; Ayliffe, Michael

2016-07-01

Mutagenesis continues to play an essential role for understanding plant gene function and, in some instances, provides an opportunity for plant improvement. The development of gene editing technologies such as TALENs and zinc fingers has revolutionised the targeted mutation specificity that can now be achieved. The CRISPR/Cas9 system is the most recent addition to gene editing technologies and arguably the simplest requiring only two components; a small guide RNA molecule (sgRNA) and Cas9 endonuclease protein which complex to recognise and cleave a specific 20 bp target site present in a genome. Target specificity is determined by complementary base pairing between the sgRNA and target site sequence enabling highly specific, targeted mutation to be readily engineered. Upon target site cleavage, error-prone endogenous repair mechanisms produce small insertion/deletions at the target site usually resulting in loss of gene function. CRISPR/Cas9 gene editing has been rapidly adopted in plants and successfully undertaken in numerous species including major crop species. Its applications are not restricted to mutagenesis and target site cleavage can be exploited to promote sequence insertion or replacement by recombination. The multiple applications of this technology in plants are described.

Deska: Tool for Central Administration of a Grid Site

NASA Astrophysics Data System (ADS)

Kundrát, Jan; Krejčová, Martina; Hubík, Tomáš; Kerpl, Lukáš

2011-12-01

Running a typical Tier-2 site requires mastering quite a few tools for fabric management. Keeping an inventory of installed HW machines, their roles and detailed information, from IP addresses to rack locations, is typically done using various in-house applications ranging from simple spreadsheets to web applications. Such solutions, whose documentation usually leaves much to be desired, typically do not prevent a significant duplication of information, and therefore the data therein quickly become obsolete. After having deployed Cfengine as one of a few sites in the WLCG environment, the Prague Tier-2 site set forth to further automate the fabric management, developing the Deska project. The aim of the system is to provide a central place to perform changes, from adding new machines or moving them between racks to changing their assigned service roles and additional metadata. The database provides an authoritative source of information from which all other systems and services (like DHCP servers, Ethernet switches or the Cfengine system) pull their data, using newly developed configuration adaptors. An easy-to-use command line interface modelled after the Cisco IOS-based switches was developed, enabling the data center administrators to easily change any information in an intuitive way. We provide an overview of the current status of the implementation and describe our design choices aimed at further reducing the system engineers' workload.

Clinical Application of Ambient Ionization Mass Spectrometry

PubMed Central

Li, Li-Hua; Hsieh, Hua-Yi; Hsu, Cheng-Chih

2017-01-01

Ambient ionization allows mass spectrometry analysis directly on the sample surface under atmospheric pressure with almost zero sample pretreatment. Since the development of desorption electrospray ionization (DESI) in 2004, many other ambient ionization techniques were developed. Due to their simplicity and low operation cost, rapid and on-site clinical mass spectrometry analysis becomes real. In this review, we will highlight some of the most widely used ambient ionization mass spectrometry approaches and their applications in clinical study. PMID:28337399

Progress and needs in agricultural research, development, and applications programs

NASA Technical Reports Server (NTRS)

Moore, D. G.; Myers, V. I.

1977-01-01

The dynamic nature of agriculture requires repetitive resource assessments such as those from remote sensing. Until recently, the use of remote sensing in agriculture has been limited primarily to site specific investigations without large-scale evaluations. Examples of successful applications at various user levels are provided. The stage of development for applying remote sensing to many agricultural problems is assessed, and goals for planning future data characteristics for increased use in agriculture are suggested.

76 FR 45242 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-28

... acquisition and/or demonstration of control of sites for new generation development of Southern Company... that document on the Applicant. In reference to filings initiating a new proceeding, interventions or...

Optimizing Characterization of Site Hydrology in Support of New Reactor Licensing at the U.S. Nuclear Regulatory Commission (Invited)

NASA Astrophysics Data System (ADS)

Nicholson, T. J.; Raione, R.; Ahn, H.; Barnhurst, D.; Giacinto, J.; McBride, M.; Tiruneh, N. D.

2009-12-01

The NRC regulates the civilian use of radioactive materials and facilities in an open and transparent manner. The NRC regulatory criteria are designed to protect human health and safety, and the environment by regulating nuclear facilities. During review of new reactor licensing applications, NRC staff reviews and independently verifies hydrogeologic information submitted by the applicant in several topical areas such as development and testing of Conceptual Site Models (CSM) which may involve perched aquifers; engineered water level fluctuations of surface-water reservoirs; ground-water collector wells and local ground-water uses; design-basis ground-water levels for structural analysis; analysis of scenarios for potential release of radionuclides to the subsurface; deep well injection of effluents; and monitoring to detect radionuclide releases. This information is reviewed in a systematic manner in accordance with NRC requirements and guidance to evaluate safety and environmental impacts and reduce the uncertainties for these impacts. NRC licensing staff is reviewing 14 applications for siting new reactors. Experience gained through these licensing activities has shown the value of using site-specific data to evaluate the CSM and its use to assess design and operational issues. Optimizing the information flow process through a systemically and thorough review process creates efficiencies. Through an iterative process of evaluating various geographical settings and associated ground-water conditions, NRC staff has developed methods to minimize prediction uncertainty through the use of confirmatory analyses performed under conservative, hierarchal approaches.

Applicability of the site fundamental frequency as a VS30 proxy for Central and Eastern North America

NASA Astrophysics Data System (ADS)

Hassani, B.; Atkinson, G. M.

2015-12-01

One of the most important issues in developing accurate ground-motion prediction equations (GMPEs) is the effective use of limited regional site information in developing a site effects model. In modern empirical GMPE models site effects are usually characterized by simplified parameters that describe the overall near-surface effects on input ground-motion shaking. The most common site effects parameter is the time-averaged shear-wave velocity in the upper 30 m (VS30), which has been used in the Next Generation Attenuation-West (NGA-West) and NGA-East GMPEs, and is widely used in building code applications. For the NGA-East GMPE database, only 6% of the stations have measured VS30 values, while the rest have proxy-based VS30 values. Proxy-based VS30 values are derived from a weighted average of different proxies' estimates such as topographic slope and surface geology proxies. For the proxy-based approaches, the uncertainty in the estimation of Vs30 is significantly higher (~0.25, log10 units) than that for stations with measured VS30(0.04, log10 units); this translates into error in site amplification and hence increased ground motion variability. We introduce a new VS30 proxy as a function of the site fundamental frequency (fpeak) using the NGA-East database, and show that fpeak is a particularly effective proxy for sites in central and eastern North America We first use horizontal to vertical spectra ratios (H/V) of 5%-damped pseudo spectral acceleration (PSA) to find the fpeak values for the recording stations. We develop an fpeak-based VS30 proxy by correlating the measured VS30 values with the corresponding fpeak value. The uncertainty of the VS30 estimate using the fpeak-based model is much lower (0.14, log10 units) than that for the proxy-based methods used in the NGA-East database (0.25 log10 units). The results of this study can be used to recalculate the VS30 values more accurately for stations with known fpeak values (23% of the stations), and potentially reduce the overall variability of the developed NGA-East GMPE models.

Integrated Toolset for WSN Application Planning, Development, Commissioning and Maintenance: The WSN-DPCM ARTEMIS-JU Project.

PubMed

Antonopoulos, Christos; Asimogloy, Katerina; Chiti, Sarah; D'Onofrio, Luca; Gianfranceschi, Simone; He, Danping; Iodice, Antonio; Koubias, Stavros; Koulamas, Christos; Lavagno, Luciano; Lazarescu, Mihai T; Mujica, Gabriel; Papadopoulos, George; Portilla, Jorge; Redondo, Luis; Riccio, Daniele; Riesgo, Teresa; Rodriguez, Daniel; Ruello, Giuseppe; Samoladas, Vasilis; Stoyanova, Tsenka; Touliatos, Gerasimos; Valvo, Angela; Vlahoy, Georgia

2016-06-02

In this article we present the main results obtained in the ARTEMIS-JU WSN-DPCM project between October 2011 and September 2015. The first objective of the project was the development of an integrated toolset for Wireless sensor networks (WSN) application planning, development, commissioning and maintenance, which aims to support application domain experts, with limited WSN expertise, to efficiently develop WSN applications from planning to lifetime maintenance. The toolset is made of three main tools: one for planning, one for application development and simulation (which can include hardware nodes), and one for network commissioning and lifetime maintenance. The tools are integrated in a single platform which promotes software reuse by automatically selecting suitable library components for application synthesis and the abstraction of the underlying architecture through the use of a middleware layer. The second objective of the project was to test the effectiveness of the toolset for the development of two case studies in different domains, one for detecting the occupancy state of parking lots and one for monitoring air concentration of harmful gasses near an industrial site.

Integrated Toolset for WSN Application Planning, Development, Commissioning and Maintenance: The WSN-DPCM ARTEMIS-JU Project

PubMed Central

Antonopoulos, Christos; Asimogloy, Katerina; Chiti, Sarah; D’Onofrio, Luca; Gianfranceschi, Simone; He, Danping; Iodice, Antonio; Koubias, Stavros; Koulamas, Christos; Lavagno, Luciano; Lazarescu, Mihai T.; Mujica, Gabriel; Papadopoulos, George; Portilla, Jorge; Redondo, Luis; Riccio, Daniele; Riesgo, Teresa; Rodriguez, Daniel; Ruello, Giuseppe; Samoladas, Vasilis; Stoyanova, Tsenka; Touliatos, Gerasimos; Valvo, Angela; Vlahoy, Georgia

2016-01-01

In this article we present the main results obtained in the ARTEMIS-JU WSN-DPCM project between October 2011 and September 2015. The first objective of the project was the development of an integrated toolset for Wireless sensor networks (WSN) application planning, development, commissioning and maintenance, which aims to support application domain experts, with limited WSN expertise, to efficiently develop WSN applications from planning to lifetime maintenance. The toolset is made of three main tools: one for planning, one for application development and simulation (which can include hardware nodes), and one for network commissioning and lifetime maintenance. The tools are integrated in a single platform which promotes software reuse by automatically selecting suitable library components for application synthesis and the abstraction of the underlying architecture through the use of a middleware layer. The second objective of the project was to test the effectiveness of the toolset for the development of two case studies in different domains, one for detecting the occupancy state of parking lots and one for monitoring air concentration of harmful gasses near an industrial site. PMID:27271622

Supervisory autonomous local-remote control system design: Near-term and far-term applications

NASA Technical Reports Server (NTRS)

Zimmerman, Wayne; Backes, Paul

1993-01-01

The JPL Supervisory Telerobotics Laboratory (STELER) has developed a unique local-remote robot control architecture which enables management of intermittent bus latencies and communication delays such as those expected for ground-remote operation of Space Station robotic systems via the TDRSS communication platform. At the local site, the operator updates the work site world model using stereo video feedback and a model overlay/fitting algorithm which outputs the location and orientation of the object in free space. That information is relayed to the robot User Macro Interface (UMI) to enable programming of the robot control macros. The operator can then employ either manual teleoperation, shared control, or supervised autonomous control to manipulate the object under any degree of time-delay. The remote site performs the closed loop force/torque control, task monitoring, and reflex action. This paper describes the STELER local-remote robot control system, and further describes the near-term planned Space Station applications, along with potential far-term applications such as telescience, autonomous docking, and Lunar/Mars rovers.

Atomically dispersed metal sites in MOF-based materials for electrocatalytic and photocatalytic energy conversion.

PubMed

Liang, Zibin; Qu, Chong; Xia, Dingguo; Zou, Ruqiang; Xu, Qiang

2018-02-19

Metal sites play an essential role for both electrocatalytic and photocatalytic energy conversion applications. The highly ordered arrangements of the organic linkers and metal nodes and the well-defined pore structures of metal-organic frameworks (MOFs) make them ideal substrates to support atomically dispersed metal sites (ADMSs) located in their metal nodes, linkers, and pores. Besides, porous carbon materials doped with ADMSs can be derived from these ADMS-incorporated MOF precursors through controlled treatments. These ADMSs incorporated in pristine MOFs and MOF-derived carbon materials possess unique merits over the molecular or the bulk metal-based catalysts, bridging the gap between homogeneous and heterogeneous catalysts for energy conversion applications. In this review, recent progress and perspective of design and incorporation of ADMSs in pristine MOFs and MOF-derived materials for energy conversion applications are highlighted, which will hopefully promote further developments of advanced MOF-based catalysts in foreseeable future. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

2005 AG20/20 Annual Review

NASA Technical Reports Server (NTRS)

Ross, Kenton W.; McKellip, Rodney D.

2005-01-01

Topics covered include: Implementation and Validation of Sensor-Based Site-Specific Crop Management; Enhanced Management of Agricultural Perennial Systems (EMAPS) Using GIS and Remote Sensing; Validation and Application of Geospatial Information for Early Identification of Stress in Wheat; Adapting and Validating Precision Technologies for Cotton Production in the Mid-Southern United States - 2004 Progress Report; Development of a System to Automatically Geo-Rectify Images; Economics of Precision Agriculture Technologies in Cotton Production-AG 2020 Prescription Farming Automation Algorithms; Field Testing a Sensor-Based Applicator for Nitrogen and Phosphorus Application; Early Detection of Citrus Diseases Using Machine Vision and DGPS; Remote Sensing of Citrus Tree Stress Levels and Factors; Spectral-based Nitrogen Sensing for Citrus; Characterization of Tree Canopies; In-field Sensing of Shallow Water Tables and Hydromorphic Soils with an Electromagnetic Induction Profiler; Maintaining the Competitiveness of Tree Fruit Production Through Precision Agriculture; Modeling and Visualizing Terrain and Remote Sensing Data for Research and Education in Precision Agriculture; Thematic Soil Mapping and Crop-Based Strategies for Site-Specific Management; and Crop-Based Strategies for Site-Specific Management.

Development of Commercial Thermo-sensitive Genic Male Sterile Rice Accelerates Hybrid Rice Breeding Using the CRISPR/Cas9-mediated TMS5 Editing System.

PubMed

Zhou, Hai; He, Ming; Li, Jing; Chen, Liang; Huang, Zhifeng; Zheng, Shaoyan; Zhu, Liya; Ni, Erdong; Jiang, Dagang; Zhao, Bingran; Zhuang, Chuxiong

2016-11-22

Hybrid rice breeding offers an important strategy to improve rice production, in which the cultivation of a male sterile line is the key to the success of cross-breeding. CRISPR/Cas9 systems have been widely used in target-site genome editing, whereas their application for crop genetic improvement has been rarely reported. Here, using the CRISPR/Cas9 system, we induced specific mutations in TMS5, which is the most widely applied thermo-sensitive genic male sterility (TGMS) gene in China, and developed new "transgene clean" TGMS lines. We designed 10 target sites in the coding region of TMS5 for targeted mutagenesis using the CRISPR/Cas9 system and assessed the potential rates of on- and off-target effects. Finally, we established the most efficient construct, the TMS5ab construct, for breeding potentially applicable "transgene clean" TGMS lines. We also discussed factors that affect the editing efficiency according to the characteristics of different target sequences. Notably, using the TMS5ab construct, we developed 11 new "transgene clean" TGMS lines with potential applications in hybrid breeding within only one year in both rice subspecies. The application of our system not only significantly accelerates the breeding of sterile lines but also facilitates the exploitation of heterosis.

Mid-Atlantic Wind - Overcoming the Challenges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel F. Ancona III; Kathryn E. George; Lynn Sparling

2012-06-29

This study, supported by the US Department of Energy, Wind Powering America Program, Maryland Department of Natural Resources and Chesapeake Bay Foundation, analyzed barriers to wind energy development in the Mid-Atlantic region along with options for overcoming or mitigating them. The Mid-Atlantic States including Delaware, Maryland, North Carolina and Virginia, have excellent wind energy potential and growing demand for electricity, but only two utility-scale projects have been installed to date. Reasons for this apathetic development of wind resources were analyzed and quantified for four markets. Specific applications are: 1) Appalachian mountain ridgeline sites, 2) on coastal plains and peninsulas, 3)more » at shallow water sites in Delaware and Chesapeake Bays, Albemarle and Pamlico Sounds, and 4) at deeper water sites off the Atlantic coast. Each market has distinctly different opportunities and barriers. The primary barriers to wind development described in this report can be grouped into four categories; state policy and regulatory issues, wind resource technical uncertainty, economic viability, and public interest in environmental issues. The properties of these typologies are not mutually independent and do interact. The report concluded that there are no insurmountable barriers to land-based wind energy projects and they could be economically viable today. Likewise potential sites in sheltered shallow waters in regional bay and sounds have been largely overlooked but could be viable currently. Offshore ocean-based applications face higher costs and technical and wind resource uncertainties. The ongoing research and development program, revision of state incentive policies, additional wind measurement efforts, transmission system expansion, environmental baseline studies and outreach to private developers and stakeholders are needed to reduce barriers to wind energy development.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crolley, R.; Thompson, M.

There has been a need for a faster and cheaper deployment model for information technology (IT) solutions to address waste management needs at US Department of Energy (DOE) complex sites for years. Budget constraints, challenges in deploying new technologies, frequent travel, and increased job demands for existing employees have prevented IT organizations from staying abreast of new technologies or deploying them quickly. Despite such challenges, IT organizations have added significant value to waste management handling through better worker safety, tracking, characterization, and disposition at DOE complex sites. Systems developed for site-specific missions have broad applicability to waste management challenges andmore » in many cases have been expanded to meet other waste missions. Radio frequency identification (RFID) and global positioning satellite (GPS)-enabled solutions have reduced the risk of radiation exposure and safety risks. New web-based and mobile applications have enabled precision characterization and control of nuclear materials. These solutions have also improved operational efficiencies and shortened schedules, reduced cost, and improved regulatory compliance. Collaboration between US Department of Energy (DOE) complex sites is improving time to delivery and cost efficiencies for waste management missions with new information technologies (IT) such as wireless computing, global positioning satellite (GPS), and radio frequency identification (RFID). Integrated solutions developed at separate DOE complex sites by new technology Centers of Excellence (CoE) have increased material control and accountability, worker safety, and environmental sustainability. CoEs offer other DOE sister sites significant cost and time savings by leveraging their technology expertise in project scoping, implementation, and ongoing operations.« less

Identification of Conserved Water Sites in Protein Structures for Drug Design.

PubMed

Jukič, Marko; Konc, Janez; Gobec, Stanislav; Janežič, Dušanka

2017-12-26

Identification of conserved waters in protein structures is a challenging task with applications in molecular docking and protein stability prediction. As an alternative to computationally demanding simulations of proteins in water, experimental cocrystallized waters in the Protein Data Bank (PDB) in combination with a local structure alignment algorithm can be used for reliable prediction of conserved water sites. We developed the ProBiS H2O approach based on the previously developed ProBiS algorithm, which enables identification of conserved water sites in proteins using experimental protein structures from the PDB or a set of custom protein structures available to the user. With a protein structure, a binding site, or an individual water molecule as a query, ProBiS H2O collects similar proteins from the PDB and performs local or binding site-specific superimpositions of the query structure with similar proteins using the ProBiS algorithm. It collects the experimental water molecules from the similar proteins and transposes them to the query protein. Transposed waters are clustered by their mutual proximity, which enables identification of discrete sites in the query protein with high water conservation. ProBiS H2O is a robust and fast new approach that uses existing experimental structural data to identify conserved water sites on the interfaces of protein complexes, for example protein-small molecule interfaces, and elsewhere on the protein structures. It has been successfully validated in several reported proteins in which conserved water molecules were found to play an important role in ligand binding with applications in drug design.

Waste information management system: a web-based system for DOE waste forecasting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geisler, T.J.; Shoffner, P.A.; Upadhyay, U.

2007-07-01

The implementation of the Department of Energy (DOE) mandated accelerated cleanup program has created significant potential technical impediments that must be overcome. The schedule compression will require close coordination and a comprehensive review and prioritization of the barriers that may impede treatment and disposition of the waste streams at each site. Many issues related to site waste treatment and disposal have now become potential critical path issues under the accelerated schedules. In order to facilitate accelerated cleanup initiatives, waste managers at DOE field sites and at DOE headquarters in Washington, D.C., need timely waste forecast information regarding the volumes andmore » types of waste that will be generated by DOE sites over the next 25 years. Each local DOE site has historically collected, organized, and displayed site waste forecast information in separate and unique systems. However, waste information from all sites needs a common application to allow interested parties to understand and view the complete complex-wide picture. A common application would allow identification of total waste volumes, material classes, disposition sites, choke points, and technological or regulatory barriers to treatment and disposal. The Applied Research Center (ARC) at Florida International University (FIU) in Miami, Florida, has completed the development of this web-based forecast system. (authors)« less

A smartphone app and analysis framework for rapidly characterizing and predicting shorebird habitat

NASA Astrophysics Data System (ADS)

Thieler, E. R.; Zeigler, S. L.; Plant, N. G.; Gutierrez, B.; Winslow, L. A.; Hines, M. K.; Read, J. S.; Walker, J. I.

2016-12-01

We developed a smartphone application called iPlover as a distributed data collection system to gather synoptic observations of shorebird habitat selection preferences, and a Bayesian network that exploits the data to predict habitat suitability. We tested this approach to modeling habitat suitability for the federally listed piping plover (Charadrius melodus) on coastal beaches and barrier islands along 1500 km of coast from North Carolina to Maine, USA. Using agile software development approaches, the iPlover application was conceived, developed and deployed in just a few months following Hurricane Sandy in 2012. This application supported collaborative efforts of nearly 100 stakeholders, resulting in over 2000 data points describing piping plover habitat selection patterns. The data were analyzed in a Bayesian network to evaluate the probability that a specific combination of habitat variables is associated with a nesting site. Subsequent testing shows that iPlover data are robust to variability in user classification and that the Bayesian network has a high level of predictive accuracy. Our work addresses a variety of scientific problems in understanding and managing dynamic coastal landscapes for beach-dependent species that require biological and geological data that (1) span the range of relevant environments and habitats, (2) can be updated seasonally to interannually, and (3) capture spatial detail. It is difficult to acquire such data; the data often have limited focus due to resource constraints, can be challenging to coordinate between different regions, are collected by non-specialists, or lack observational uniformity. Furthermore, associated data analysis techniques are often limited in their ability to consider new information as data are collected from additional study sites and updated. We present examples of how this approach can be used to map past, present, and future habitat suitability for sites of interest. We also describe lessons learned and identify several elements of scientific mobile applications that increase the likelihood for success during development, implementation, and maintenance. Methods used here to develop and exploit a distributed data collection system have broad applicability to interdisciplinary environmental monitoring, modeling and management.

A method for independent modelling in support of regulatory review of dose assessments.

PubMed

Dverstorp, Björn; Xu, Shulan

2017-11-01

Several countries consider geological disposal facilities as the preferred option for spent nuclear fuel due to their potential to provide isolation from the surface environment on very long timescales. In 2011 the Swedish Nuclear Fuel & Waste Management Co. (SKB) submitted a license application for construction of a spent nuclear fuel repository. The disposal method involves disposing spent fuel in copper canisters with a cast iron insert at about 500 m depth in crystalline basement rock, and each canister is surrounded by a buffer of swelling bentonite clay. SKB's license application is supported by a post-closure safety assessment, SR-Site. SR-Site has been reviewed by the Swedish Radiation Safety Authority (SSM) for five years. The main method for review of SKB's license application is document review, which is carried out by SSM's staff and supported by SSM's external experts. The review has proven a challenging task due to its broad scope, complexity and multidisciplinary nature. SSM and its predecessors have, for several decades, been developing independent models to support regulatory reviews of post-closure safety assessments for geological repositories. For the review of SR-Site, SSM has developed a modelling approach with a structured application of independent modelling activities, including replication modelling, use of alternative conceptual models and bounding calculations, to complement the traditional document review. This paper describes this scheme and its application to biosphere and dose assessment modelling. SSM's independent modelling has provided important insights regarding quality and reasonableness of SKB's rather complex biosphere modelling and has helped quantifying conservatisms and highlighting conceptual uncertainty. Copyright © 2017 Elsevier Ltd. All rights reserved.

Fertilization, weed control, and pine litter influence loblolly pine stem productivity and root development

Treesearch

James D. Haywood; Allan E. Tiarks; Mary A. Sword

1997-01-01

Following site preparation, three cultural treatments and three open-pollinated loblolly pine (Pinus taeda L.) families were studied on a gently sloping Beauregard silt loam in central Louisiana. The treatments were: (1) fertilization (either broadcast application of 177 kg N and 151 kg P/ha or none); (2) herbicide application (either broadcast...

75 FR 63195 - Notice of Availability: Notice of Funding Availability (NOFA) for HUD's Fiscal Year (FY) 2010...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-14

... Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm... Production Grant Program is 14.913. Applications must be submitted electronically through Grants.gov . FOR...

75 FR 67393 - Notice of Availability: Notice of Funding Availability (NOFA) for HUD's Fiscal Year 2010 Resident...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm... Coordinator Program is 14.870. Applications must be submitted electronically through Grants.gov . FOR FURTHER...

75 FR 63196 - Notice of Availability: Notice of Funding Availability (NOFA) for Fiscal Year (FY) 2010 Family...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-14

... Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm... Unification Program is 14.880. Applications must be submitted electronically through Grants.gov . FOR FURTHER...

Expanding the scope of site-specific recombinases for genetic and metabolic engineering.

PubMed

Gaj, Thomas; Sirk, Shannon J; Barbas, Carlos F

2014-01-01

Site-specific recombinases are tremendously valuable tools for basic research and genetic engineering. By promoting high-fidelity DNA modifications, site-specific recombination systems have empowered researchers with unprecedented control over diverse biological functions, enabling countless insights into cellular structure and function. The rigid target specificities of many sites-specific recombinases, however, have limited their adoption in fields that require highly flexible recognition abilities. As a result, intense effort has been directed toward altering the properties of site-specific recombination systems by protein engineering. Here, we review key developments in the rational design and directed molecular evolution of site-specific recombinases, highlighting the numerous applications of these enzymes across diverse fields of study. © 2013 Wiley Periodicals, Inc.

Possibility to Use Mobile Learning to Promote World Heritage Site Preservation Awareness in Luang Prabang, Lao Pdr: a Readiness Study

NASA Astrophysics Data System (ADS)

Poong, Y. S.; Yamaguchi, S.; Takada, J.

2013-07-01

This paper elucidates the current state of mobile technology readiness among young adults in higher education institution based on surveys and interviews. Although Lao PDR is ranked as low category in the ICT Index by International Telecommunication Union (ITU), findings show that there exists high level of readiness among the young adults. Recommendations for future research are developed to guide the development of mobile learning application with the aim to promote World Heritage Site preservation awareness.

Evaluating the adequacy of a reference site pool for ecological assessments in environmentally complex regions

USGS Publications Warehouse

Ode, Peter R.; Rehn, Andrew C.; Mazor, Raphael D.; Schiff, Kenneth C.; Stein, Eric D.; May, Jason; Brown, Larry R.; Herbst, David B.; Gillette, D.D.; Lunde, Kevin; Hawkins, Charles P.

2016-01-01

Many advances in the field of bioassessment have focused on approaches for objectively selecting the pool of reference sites used to establish expectations for healthy waterbodies, but little emphasis has been placed on ways to evaluate the suitability of the reference-site pool for its intended applications (e.g., compliance assessment vs ambient monitoring). These evaluations are critical because an inadequately evaluated reference pool may bias assessments in some settings. We present an approach for evaluating the adequacy of a reference-site pool for supporting biotic-index development in environmentally heterogeneous and pervasively altered regions. We followed common approaches for selecting sites with low levels of anthropogenic stress to screen 1985 candidate stream reaches to create a pool of 590 reference sites for assessing the biological integrity of streams in California, USA. We assessed the resulting pool of reference sites against 2 performance criteria. First, we evaluated how well the reference-site pool represented the range of natural gradients present in the entire population of streams as estimated by sites sampled through probabilistic surveys. Second, we evaluated the degree to which we were successful in rejecting sites influenced by anthropogenic stress by comparing biological metric scores at reference sites with the most vs fewest potential sources of stress. Using this approach, we established a reference-site pool with low levels of human-associated stress and broad coverage of environmental heterogeneity. This approach should be widely applicable and customizable to particular regional or programmatic needs.

Techniques for estimating flood-peak discharges from urban basins in Missouri

USGS Publications Warehouse

Becker, L.D.

1986-01-01

Techniques are defined for estimating the magnitude and frequency of future flood peak discharges of rainfall-induced runoff from small urban basins in Missouri. These techniques were developed from an initial analysis of flood records of 96 gaged sites in Missouri and adjacent states. Final regression equations are based on a balanced, representative sampling of 37 gaged sites in Missouri. This sample included 9 statewide urban study sites, 18 urban sites in St. Louis County, and 10 predominantly rural sites statewide. Short-term records were extended on the basis of long-term climatic records and use of a rainfall-runoff model. Linear least-squares regression analyses were used with log-transformed variables to relate flood magnitudes of selected recurrence intervals (dependent variables) to selected drainage basin indexes (independent variables). For gaged urban study sites within the State, the flood peak estimates are from the frequency curves defined from the synthesized long-term discharge records. Flood frequency estimates are made for ungaged sites by using regression equations that require determination of the drainage basin size and either the percentage of impervious area or a basin development factor. Alternative sets of equations are given for the 2-, 5-, 10-, 25-, 50-, and 100-yr recurrence interval floods. The average standard errors of estimate range from about 33% for the 2-yr flood to 26% for the 100-yr flood. The techniques for estimation are applicable to flood flows that are not significantly affected by storage caused by manmade activities. Flood peak discharge estimating equations are considered applicable for sites on basins draining approximately 0.25 to 40 sq mi. (Author 's abstract)

Factors influencing the spatial distribution of Anopheles larvae in Coimbatore District, Tamil Nadu, India.

PubMed

Arjunan, Naresh Kumar; Kadarkarai, Murugan; Kumar, Shobana; Pari, Madhiyazhagan; Thiyagarajan, Nataraj; Vincent, C Thomas; Barnard, Donald R

2015-12-01

Malaria causes extensive morbidity and mortality in humans and results in significant economic losses in India. The distribution of immature malaria-transmitting Anopheles mosquitoes was studied in 17 villages in Coimbatore District as a prelude to the development and implementation of vector control strategies that are intended to reduce the risk of human exposure to potentially infectious mosquitoes. Eight Anopheles species were recorded. The most numerous species were Anopheles vagus, Anopheles subpictus, and Anopheles hyrcanus. The location of mosquito development sites and the density of larvae in each village was evaluated for correlation with selected demographic, biologic, and land use parameters using remote sensing and geographic information systems (GIS) technology. We found the number of mosquito development sites in a village and the density of larvae in such sites to be positively correlated with human population density but not the surface area (km(2)) of the village. The number of mosquito development sites and the density of larvae in each site were not correlated. Data from this study are being used to construct a GIS-based mapping system that will enable the location of aquatic habitats with Anopheles larvae in the Coimbatore District, Tamil Nadu, India as target sites for the application of vector control. Copyright © 2015 Elsevier B.V. All rights reserved.

Visual impact assessment in British oil and gas developments

Treesearch

Dennis F. Gillespie; Brian D. Clark

1979-01-01

Development of oil and gas resource in the North Sea has led to the application of visual impact assessment techniques to onshore oil and gas developments in the United Kingdom. Formal visual impact assessment methods are needed to supplement landscape evaluations and site selection studies. Three major orientations of British visual impact assessments are: the...

DEVELOPMENT OF A FISH INDEX OF BIOTIC INTEGRITY TO ASSESS THE CONDITION OF WEST VIRGINIA STREAMS: TECHNICAL SUPPORT DOCUMENT

EPA Science Inventory

This report documents the development of a fish index of biotic integrity (IBI) for wadeable streams in West Virginia and to determine the applicability of the IBI in streams with different thermal regimes. The IBI will be developed using fish data collected at EMAP sites from 1...

Deriving Forest Harvesting Machine Productivity from Positional Data

Treesearch

T.P. McDonald; S.E. Taylor; R.B. Rummer

2000-01-01

Automated production study systems will provide researchers a valuable tool for developing cost and impact models of forest operations under a wide range of conditions, making the development of true planning tools for tailoring logging systems to a particular site a reality. An automated time study system for skidders was developed, and in this study application of...

78 FR 59662 - Annual Public Meeting of the Interagency Steering Committee on Multimedia Environmental Modeling

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-27

... applications and assessment of site specific, generic, and process-oriented multimedia environmental models as... development and simulation supports interagency interests in risk assessment, uncertainty analyses, management...

15 CFR 921.80 - Application information.

Code of Federal Regulations, 2011 CFR

2011-01-01

...-site selection, operation and management, research, and education and interpretive awards. The... MANAGEMENT NATIONAL ESTUARINE RESEARCH RESERVE SYSTEM REGULATIONS General Financial Assistance Provisions... awards for preacquisition, acquisition and development, operation and management, and special education...

Market Transformation | Hydrogen and Fuel Cells | NREL

Science.gov Websites

deployment sites Develop techno-economic assessment tools, deployment tools, and business cases for various fuel cell applications Collect and evaluate data from deployment projects to verify the business cases

Development of the hard and soft constraints based optimisation model for unit sizing of the hybrid renewable energy system designed for microgrid applications

NASA Astrophysics Data System (ADS)

Sundaramoorthy, Kumaravel

2017-02-01

The hybrid energy systems (HESs) based electricity generation system has become a more attractive solution for rural electrification nowadays. Economically feasible and technically reliable HESs are solidly based on an optimisation stage. This article discusses about the optimal unit sizing model with the objective function to minimise the total cost of the HES. Three typical rural sites from southern part of India have been selected for the application of the developed optimisation methodology. Feasibility studies and sensitivity analysis on the optimal HES are discussed elaborately in this article. A comparison has been carried out with the Hybrid Optimization Model for Electric Renewable optimisation model for three sites. The optimal HES is found with less total net present rate and rate of energy compared with the existing method

NASA's Software Bank (CLIPS)

NASA Technical Reports Server (NTRS)

1991-01-01

C Language Integrated Production System (CLIPS) is a NASA Johnson Space Center developed software shell for developing expert systems, is used by researchers at Ohio State University to determine solid waste disposal sites to assist in historic preservation. The program has various other applications and has even been included in a widely-used textbook.

Landscape assessment for tourism

Treesearch

Clare A. Gunn

1979-01-01

Increased development of landscapes for tourism now creates problems of integrating the many parts. Accomplishments at the site scale have not been matched with equal progress at the regional scale. This concept, and its example of application, shows promise of assisting regions in assessing their potential of landscapes before development. With such a concept, not...

Development of smart spray systems to enhance delivery of pesticides in field nursery production

USDA-ARS?s Scientific Manuscript database

Two smart sprayer prototypes have been developed and are being evaluated with a goal of increasing pesticide application efficiency and minimizing environmental impact in field nursery production sites. The first prototype, a modified hydraulic vertical boom system, utilizes ultrasonic sensors to d...

Testing a small UAS for mapping artisanal diamond mining sites in Africa

USGS Publications Warehouse

Malpeli, Katherine C.; Chirico, Peter G.

2015-01-01

Remote sensing technology is advancing at an unprecedented rate. At the forefront of the new technological developments are unmanned aircraft systems (UAS). The advent of small, lightweight, low-cost, and user-friendly UAS is greatly expanding the potential applications of remote sensing technology and improving the set of tools available to researchers seeking to map and monitor terrain from above. In this article, we explore the applications of a small UAS for mapping informal diamond mining sites in Africa. We found that this technology provides aerial imagery of unparalleled resolution in a data-sparse, difficult to access, and remote terrain.

[Application of three compartment model and response surface model to clinical anesthesia using Microsoft Excel].

PubMed

Abe, Eiji; Abe, Mari

2011-08-01

With the spread of total intravenous anesthesia, clinical pharmacology has become more important. We report Microsoft Excel file applying three compartment model and response surface model to clinical anesthesia. On the Microsoft Excel sheet, propofol, remifentanil and fentanyl effect-site concentrations are predicted (three compartment model), and probabilities of no response to prodding, shaking, surrogates of painful stimuli and laryngoscopy are calculated using predicted effect-site drug concentration. Time-dependent changes in these calculated values are shown graphically. Recent development in anesthetic drug interaction studies are remarkable, and its application to clinical anesthesia with this Excel file is simple and helpful for clinical anesthesia.

Proceedings of Small Power Systems Solar Electric Workshop. Volume 2: Invited papers

NASA Technical Reports Server (NTRS)

Ferber, R. (Editor)

1978-01-01

The focus of this work shop was to present the committment to the development of solar thermal power plants for a variety of applications including utility applications. Workshop activities included panel discussions, formal presentations, small group interactive discussions, question and answer periods, and informal gatherings. Discussion on topics include: (1) solar power technology options; (2) solar thermal power programs currently underway at the DOE, JPL, Electric Power Research Institute (EPRI), and Solar Energy Research Institute (SERI); (3) power options competing with solar; (4) institutional issues; (5) environmental and siting issues; (6) financial issues; (7) energy storage; (8) site requirements for experimental solar installations, and (9) utility planning.

Pose tracking for augmented reality applications in outdoor archaeological sites

NASA Astrophysics Data System (ADS)

Younes, Georges; Asmar, Daniel; Elhajj, Imad; Al-Harithy, Howayda

2017-01-01

In recent years, agencies around the world have invested huge amounts of effort toward digitizing many aspects of the world's cultural heritage. Of particular importance is the digitization of outdoor archaeological sites. In the spirit of valorization of this digital information, many groups have developed virtual or augmented reality (AR) computer applications themed around a particular archaeological object. The problem of pose tracking in outdoor AR applications is addressed. Different positional systems are analyzed, resulting in the selection of a monocular camera-based user tracker. The limitations that challenge this technique from map generation, scale, anchoring, to lighting conditions are analyzed and systematically addressed. Finally, as a case study, our pose tracking system is implemented within an AR experience in the Byblos Roman theater in Lebanon.

Environmental Research Translation: Enhancing Interactions with Communities at Contaminated Sites

NASA Astrophysics Data System (ADS)

Ramirez-Andreotta, M.; Brusseau, M. L. L.; Artiola, J. F.; Maier, R. M.; Gandolfi, A. J.

2015-12-01

The characterization and remediation of contaminated sites are complex endeavors fraught with numerous challenges. One particular challenge that is receiving increased attention is the development and encouragement of full participation by communities and community members affected by a given site in all facets of decision-making. Many disciplines have been grappling with the challenges associated with environmental and risk communication, public participation in environmental data generation and decision-making, and increasing community capacity. The concepts and methods developed by these disciplines are reviewed, with a focus on their relevance to the specific dynamics associated with contaminated sites. The contributions of these disciplines are then synthesized and integrated to help develop Environmental Research Translation (ERT), a proposed framework for environmental scientists to promote interaction and communication among involved parties at contaminated sites. This holistic approach is rooted in public participation approaches to science, which includes: a transdisciplinary team, effective collaboration, information transfer, public participation in environmental projects, and a cultural model of risk communication. Although there are challenges associated with the implementation of ERT, it is anticipated that application of this proposed translational science method could promote more robust community participation at contaminated sites.

Environmental Research Translation: Enhancing Interactions with Communities at Contaminated Sites

PubMed Central

Ramirez-Andreotta, Monica D.; Brusseau, Mark L.; Artiola, Janick F.; Maier, Raina M.; Gandolfi, A. Jay

2014-01-01

The characterization and remediation of contaminated sites are complex endeavors fraught with numerous challenges. One particular challenge that is receiving increased attention is the development and encouragement of full participation by communities and community members affected by a given site in all facets of decision-making. Many disciplines have been grappling with the challenges associated with environmental and risk communication, public participation in environmental data generation, and decision-making and increasing community capacity. The concepts and methods developed by these disciplines are reviewed, with a focus on their relevance to the specific dynamics associated with environmental contamination sites. The contributions of these disciplines are then synthesized and integrated to help develop Environmental Research Translation (ERT), a proposed framework for environmental scientists to promote interaction and communication among involved parties at contaminated sites. This holistic approach is rooted in public participation approaches to science, which includes: a transdisciplinary team, effective collaboration, information transfer, public participation in environmental projects, and a cultural model of risk communication. Although there are challenges associated with the implementation of ERT, it is anticipated that application of this proposed translational science method could promote more robust community participation at contaminated sites. PMID:25173762

Health and safety impacts of nuclear, geothermal, and fossil-fuel electric generation in California. Volume 9. Methodologies for review of the health and safety aspects of proposed nuclear, geothermal, and fossil-fuel sites and facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nero, A.V.; Quinby-Hunt, M.S.

1977-01-01

This report sets forth methodologies for review of the health and safety aspects of proposed nuclear, geothermal, and fossil-fuel sites and facilities for electric power generation. The review is divided into a Notice of Intention process and an Application for Certification process, in accordance with the structure to be used by the California Energy Resources Conservation and Development Commission, the first emphasizing site-specific considerations, the second examining the detailed facility design as well. The Notice of Intention review is divided into three possible stages: an examination of emissions and site characteristics, a basic impact analysis, and an assessment of publicmore » impacts. The Application for Certification review is divided into five possible stages: a review of the Notice of Intention treatment, review of the emission control equipment, review of the safety design, review of the general facility design, and an overall assessment of site and facility acceptability.« less

[Application of multiple-attribute utility technology (MAUT) to decisions about a work-site stress-control intervention for public-sector office workers].

PubMed

Hagihara, Akihito; Tarumi, Kimio

2013-01-01

The reasons behind the establishment of particular health-promotion programs in community or work settings are often unclear, and such programs are rarely evaluated from a broad perspective after they are implemented. Thus, multiattribute utility technology (MAUT) was used to design a work-site stress-control program. The sample consisted of public-sector workers in B City in Japan. Stakeholders in the work-site stress-control program included employers (municipal authorities), employees (public workers), and healthcare personnel. Six goals and three strategies (i.e., personnel, self-care, and staff) related to stress-control programs were considered. The results showed that the self-care strategy received the highest score for overall utility (i.e., 96.2), and the overall-utility score for the remaining two strategies was approximately 70. The self-care strategy emerged as the most useful of the three strategies for developing a stress-control program in a target work place. The application of MAUT may be useful for developing an effective stress-control program in occupational settings.

76 FR 34649 - Foreign-Trade Zone 119-Minneapolis-St. Paul, MN; Application for Reorganization Under Alternative...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

...--Minneapolis-St. Paul, MN; Application for Reorganization Under Alternative Site Framework An application has... current zone project includes the following sites: Site 1 (3,002 acres)--located at the Minneapolis-St...); Site 9 (20 acres)--1700 Wynne Avenue, St. Paul (Ramsey County); and, Site 10 (236 acres)-- Bloomington...

10 CFR 2.623 - Notice of hearing on application for early review of site suitability issues in combined license...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Notice of hearing on application for early review of site... Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application for a... Limited Work Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part...

10 CFR 2.604 - Notice of hearing on application for early review of site suitability issues in construction...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Notice of hearing on application for early review of site... Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application for a... Limited Work Authorizations Early Partial Decisions on Site Suitability-Construction Permit § 2.604 Notice...

10 CFR 2.623 - Notice of hearing on application for early review of site suitability issues in combined license...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Notice of hearing on application for early review of site... Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application for a... Limited Work Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part...

10 CFR 2.623 - Notice of hearing on application for early review of site suitability issues in combined license...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Notice of hearing on application for early review of site... Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application for a... Limited Work Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part...

10 CFR 2.604 - Notice of hearing on application for early review of site suitability issues in construction...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Notice of hearing on application for early review of site... Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application for a... Limited Work Authorizations Early Partial Decisions on Site Suitability-Construction Permit § 2.604 Notice...

10 CFR 2.604 - Notice of hearing on application for early review of site suitability issues in construction...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Notice of hearing on application for early review of site... Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application for a... Limited Work Authorizations Early Partial Decisions on Site Suitability-Construction Permit § 2.604 Notice...

Innovation Technologies and Applications for Coastal Archaeological sites

NASA Astrophysics Data System (ADS)

Di Iorio, A.; Biliouris, D.; Guzinski, R.; Hansen, L. B.; Bagni, M.

2015-04-01

Innovation Technologies and Applications for Coastal Archaeological sites project (ITACA) aims to develop and test a management system for underwater archaeological sites in coastal regions. The discovering and monitoring service will use innovative satellite remote sensing techniques combined with image processing algorithms. The project will develop a set of applications integrated in a system pursuing the following objectives: - Search and location of ancient ship wrecks; - Monitoring of ship wrecks, ruins and historical artefacts that are now submerged; - Integration of resulting search and monitoring data with on-site data into a management tool for underwater sites; - Demonstration of the system's suitability for a service. High resolution synthetic aperture radar (TerraSAR-X, Cosmo-SkyMed) and multispectral satellite data (WorldView) will be combined to derive the relative bathymetry of the bottom of the sea up to the depth of 50 meters. The resulting data fusion will be processed using shape detection algorithms specific for archaeological items. The new algorithms, the physical modelling and the computational capabilities will be integrated into the Web-GIS, together with data recorded from surface (2D and 3D modelling) and from underwater surveys. Additional specific archaeological layers will be included into the WebGIS to facilitate the object identification through shape detection techniques and mapping. The system will be verified and validated through an extensive onground (sea) campaign carried out with both cutting edge technologies (side-scan sonar, multi beam echo sounder) and traditional means (professional scuba divers) in two test sites in Italy and Greece. The project is leaded by Planetek Hellas E.P.E. and include ALMA Sistemi sas for the "shape detection" and dissemination tasks, DHI-GRAS and Kell Srl for multispectral and SAR bathymetry. The complete consortium is composed by eleven partners and the project Kick-Off has been held in January 2014. The present contribution aims to present the project research achievements and finding at the mid-term review.

Current progress of targetron technology: development, improvement and application in metabolic engineering.

PubMed

Liu, Ya-Jun; Zhang, Jie; Cui, Gu-Zhen; Cui, Qiu

2015-06-01

Targetrons are mobile group II introns that can recognize their DNA target sites by base-pairing RNA-DNA interactions with the aid of site-specific binding reverse transcriptases. Targetron technology stands out from recently developed gene targeting methods because of the flexibility, feasibility, and efficiency, and is particularly suitable for the genetic engineering of difficult microorganisms, including cellulolytic bacteria that are considered promising candidates for biomass conversion via consolidated bioprocessing. Along with the development of the thermotargetron method for thermophiles, targetron technology becomes increasingly important for the metabolic engineering of industrial microorganisms aiming at biofuel/chemical production. To summarize the current progress of targetron technology and provide new insights on the use of the technology, this paper reviews the retrohoming mechanisms of both mesophilic and thermophilic targetron methods based on various group II introns, investigates the improvement of targetron tools for high target efficiency and specificity, and discusses the current applications in the metabolic engineering for bacterial producers. Although there are still intellectual property and technical restrictions in targetron applications, we propose that targetron technology will contribute to both biochemistry research and the metabolic engineering for industrial productions. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Musite, a tool for global prediction of general and kinase-specific phosphorylation sites.

PubMed

Gao, Jianjiong; Thelen, Jay J; Dunker, A Keith; Xu, Dong

2010-12-01

Reversible protein phosphorylation is one of the most pervasive post-translational modifications, regulating diverse cellular processes in various organisms. High throughput experimental studies using mass spectrometry have identified many phosphorylation sites, primarily from eukaryotes. However, the vast majority of phosphorylation sites remain undiscovered, even in well studied systems. Because mass spectrometry-based experimental approaches for identifying phosphorylation events are costly, time-consuming, and biased toward abundant proteins and proteotypic peptides, in silico prediction of phosphorylation sites is potentially a useful alternative strategy for whole proteome annotation. Because of various limitations, current phosphorylation site prediction tools were not well designed for comprehensive assessment of proteomes. Here, we present a novel software tool, Musite, specifically designed for large scale predictions of both general and kinase-specific phosphorylation sites. We collected phosphoproteomics data in multiple organisms from several reliable sources and used them to train prediction models by a comprehensive machine-learning approach that integrates local sequence similarities to known phosphorylation sites, protein disorder scores, and amino acid frequencies. Application of Musite on several proteomes yielded tens of thousands of phosphorylation site predictions at a high stringency level. Cross-validation tests show that Musite achieves some improvement over existing tools in predicting general phosphorylation sites, and it is at least comparable with those for predicting kinase-specific phosphorylation sites. In Musite V1.0, we have trained general prediction models for six organisms and kinase-specific prediction models for 13 kinases or kinase families. Although the current pretrained models were not correlated with any particular cellular conditions, Musite provides a unique functionality for training customized prediction models (including condition-specific models) from users' own data. In addition, with its easily extensible open source application programming interface, Musite is aimed at being an open platform for community-based development of machine learning-based phosphorylation site prediction applications. Musite is available at http://musite.sourceforge.net/.

Quality assurance of nursing web sites: development and implications of the ALEU method.

PubMed

Cambil-Martín, Jacobo; Flynn, Maria; Villaverde-Gutiérrez, Carmen

2011-09-01

This article presents a study that evaluated the physical accessibility, readability, and usability of Spanish nursing Web sites and discusses the quality assurance issues raised, which are relevant to the wider nursing community. The Internet is recognized as an important source of health information for both nurses and the general public. Although it makes health-related information universally available, the wide variation in the overall quality of health Web sites is problematic. This raises many questions for the nursing profession: about what constitutes a good-quality Web site, about the nature of the information that nurses are finding and using to support their professional education, research, and clinical practice, and about the impact that Internet information ultimately has on health interactions and nursing care. The process of completing this small study showed that it is possible to usefully assess dimensions of Web site quality and suggested that it may be feasible to develop tools to help nurses evaluate national and international nursing Web sites. More research is needed to understand how nurses use the Internet to support their everyday professional practices, but the development and application of international Web site quality assurance tools may be important for maintaining professional nursing standards in the Internet age.

An AgMIP framework for improved agricultural representation in integrated assessment models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruane, Alex C.; Rosenzweig, Cynthia; Asseng, Senthold

Integrated assessment models (IAMs) hold great potential to assess how future agricultural systems will be shaped by socioeconomic development, technological innovation, and changing climate conditions. By coupling with climate and crop model emulators, IAMs have the potential to resolve important agricultural feedback loops and identify unintended consequences of socioeconomic development for agricultural systems. Here we propose a framework to develop robust representation of agricultural system responses within IAMs, linking downstream applications with model development and the coordinated evaluation of key climate responses from local to global scales. We survey the strengths and weaknesses of protocol-based assessments linked to the Agriculturalmore » Model Intercomparison and Improvement Project (AgMIP), each utilizing multiple sites and models to evaluate crop response to core climate changes including shifts in carbon dioxide concentration, temperature, and water availability, with some studies further exploring how climate responses are affected by nitrogen levels and adaptation in farm systems. Site-based studies with carefully calibrated models encompass the largest number of activities; however they are limited in their ability to capture the full range of global agricultural system diversity. Representative site networks provide more targeted response information than broadly-sampled networks, with limitations stemming from difficulties in covering the diversity of farming systems. Global gridded crop models provide comprehensive coverage, although with large challenges for calibration and quality control of inputs. Diversity in climate responses underscores that crop model emulators must distinguish between regions and farming system while recognizing model uncertainty. Finally, to bridge the gap between bottom-up and top-down approaches we recommend the deployment of a hybrid climate response system employing a representative network of sites to bias-correct comprehensive gridded simulations, opening the door to accelerated development and a broad range of applications.« less

An AgMIP framework for improved agricultural representation in integrated assessment models

NASA Astrophysics Data System (ADS)

Ruane, Alex C.; Rosenzweig, Cynthia; Asseng, Senthold; Boote, Kenneth J.; Elliott, Joshua; Ewert, Frank; Jones, James W.; Martre, Pierre; McDermid, Sonali P.; Müller, Christoph; Snyder, Abigail; Thorburn, Peter J.

2017-12-01

Integrated assessment models (IAMs) hold great potential to assess how future agricultural systems will be shaped by socioeconomic development, technological innovation, and changing climate conditions. By coupling with climate and crop model emulators, IAMs have the potential to resolve important agricultural feedback loops and identify unintended consequences of socioeconomic development for agricultural systems. Here we propose a framework to develop robust representation of agricultural system responses within IAMs, linking downstream applications with model development and the coordinated evaluation of key climate responses from local to global scales. We survey the strengths and weaknesses of protocol-based assessments linked to the Agricultural Model Intercomparison and Improvement Project (AgMIP), each utilizing multiple sites and models to evaluate crop response to core climate changes including shifts in carbon dioxide concentration, temperature, and water availability, with some studies further exploring how climate responses are affected by nitrogen levels and adaptation in farm systems. Site-based studies with carefully calibrated models encompass the largest number of activities; however they are limited in their ability to capture the full range of global agricultural system diversity. Representative site networks provide more targeted response information than broadly-sampled networks, with limitations stemming from difficulties in covering the diversity of farming systems. Global gridded crop models provide comprehensive coverage, although with large challenges for calibration and quality control of inputs. Diversity in climate responses underscores that crop model emulators must distinguish between regions and farming system while recognizing model uncertainty. Finally, to bridge the gap between bottom-up and top-down approaches we recommend the deployment of a hybrid climate response system employing a representative network of sites to bias-correct comprehensive gridded simulations, opening the door to accelerated development and a broad range of applications.

EPA Policy for Innovative Environmental Technologies at Federal Facilities

EPA Pesticide Factsheets

This is a memo from the EPA Administrator, regarding the unique opportunities for the development and application of innovative technologies and approaches to pollution prevention, source control, site investigation, and remediation at Federal facilities.

15 CFR 921.80 - Application information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... awards for preacquisition, acquisition and development, operation and management, and special education...-site selection, operation and management, research, and education and interpretive awards. The... projects, or restorative activities involving construction, must include a preliminary engineering report...

Development of a geophysical data fusion system for assessment and remediation studies of polluted groundwater aquifers. Scientific report No. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murphy, J.R.; O`Neill, D.C.; Barker, B.W.

1994-10-01

The research described in this report is directed toward the development of a workstation-based data management, analysis and visualization system which can be used to improve the Air Force`s capability to evaluate site specific environmental hazards. The initial prototype system described in this report is directed toward a specific application to the Massachusetts Military Reservation (formerly Otis Air Force Base) on Cape Cod, Massachusetts. This system integrates a comprehensive, on-line environmental database for the site together with a map-based graphical user interface which facilitates analyst access to the databases and analysis tools needed to characterize the subsurface geologic and hydrologicmore » environments at the site.« less

Watershed modeling at the Savannah River Site.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vache, Kellie

2015-04-29

The overall goal of the work was the development of a watershed scale model of hydrological function for application to the US Department of Energy’s (DOE) Savannah River Site (SRS). The primary outcomes is a grid based hydrological modeling system that captures near surface runoff as well as groundwater recharge and contributions of groundwater to streams. The model includes a physically-based algorithm to capture both evaporation and transpiration from forestland.

Development and Applications of Technology for Sensing Zooplankton

DTIC Science & Technology

2003-09-30

zooplankton-like particles. WORK COMPLETED In support of our first objective, in prior years we occupied sites in both East and West Sound at Orcas ...Island in northern Puget Sound , WA. We have also made deployments at four sites on open linear coasts, including one just north of Oceanside, CA (Red...layers. Multi-static, multi-frequency methods Most active bioacoustical methods in oceanography exclusively utilize the sound that is scattered

Generation of therapeutic protein variants with the human serum albumin binding capacity via site-specific fatty acid conjugation.

PubMed

Cho, Jinhwan; Lim, Sung In; Yang, Byung Seop; Hahn, Young S; Kwon, Inchan

2017-12-21

Extension of the serum half-life is an important issue in developing new therapeutic proteins and expanding applications of existing therapeutic proteins. Conjugation of fatty acid, a natural human serum albumin ligand, to a therapeutic protein/peptide was developed as a technique to extend the serum half-life in vivo by taking advantages of unusually long serum half-life of human serum albumin (HSA). However, for broad applications of fatty acid-conjugation, several issues should be addressed, including a poor solubility of fatty acid and a substantial loss in the therapeutic activity. Therefore, herein we systematically investigate the conditions and components in conjugation of fatty acid to a therapeutic protein resulting in the HSA binding capacity without compromising therapeutic activities. By examining the crystal structure and performing dye conjugation assay, two sites (W160 and D112) of urate oxidase (Uox), a model therapeutic protein, were selected as sites for fatty acid-conjugation. Combination of site-specific incorporation of a clickable p-azido-L-phenylalanine to Uox and strain-promoted azide-alkyne cycloaddition allowed the conjugation of fatty acid (palmitic acid analog) to Uox with the HSA binding capacity and retained enzyme activity. Deoxycholic acid, a strong detergent, greatly enhanced the conjugation yield likely due to the enhanced solubility of palmitic acid analog.

Phosphoric Acid Fuel Cell Technology Status

NASA Technical Reports Server (NTRS)

Simons, S. N.; King, R. B.; Prokopius, P. R.

1981-01-01

A review of the current phosphoric acid fuel cell system technology development efforts is presented both for multimegawatt systems for electric utility applications and for multikilowatt systems for on-site integrated energy system applications. Improving fuel cell performance, reducing cost, and increasing durability are the technology drivers at this time. Electrodes, matrices, intercell cooling, bipolar/separator plates, electrolyte management, and fuel selection are discussed.

Rapid Prototyping of Hydrologic Model Interfaces with IPython

NASA Astrophysics Data System (ADS)

Farthing, M. W.; Winters, K. D.; Ahmadia, A. J.; Hesser, T.; Howington, S. E.; Johnson, B. D.; Tate, J.; Kees, C. E.

2014-12-01

A significant gulf still exists between the state of practice and state of the art in hydrologic modeling. Part of this gulf is due to the lack of adequate pre- and post-processing tools for newly developed computational models. The development of user interfaces has traditionally lagged several years behind the development of a particular computational model or suite of models. As a result, models with mature interfaces often lack key advancements in model formulation, solution methods, and/or software design and technology. Part of the problem has been a focus on developing monolithic tools to provide comprehensive interfaces for the entire suite of model capabilities. Such efforts require expertise in software libraries and frameworks for creating user interfaces (e.g., Tcl/Tk, Qt, and MFC). These tools are complex and require significant investment in project resources (time and/or money) to use. Moreover, providing the required features for the entire range of possible applications and analyses creates a cumbersome interface. For a particular site or application, the modeling requirements may be simplified or at least narrowed, which can greatly reduce the number and complexity of options that need to be accessible to the user. However, monolithic tools usually are not adept at dynamically exposing specific workflows. Our approach is to deliver highly tailored interfaces to users. These interfaces may be site and/or process specific. As a result, we end up with many, customized interfaces rather than a single, general-use tool. For this approach to be successful, it must be efficient to create these tailored interfaces. We need technology for creating quality user interfaces that is accessible and has a low barrier for integration into model development efforts. Here, we present efforts to leverage IPython notebooks as tools for rapid prototyping of site and application-specific user interfaces. We provide specific examples from applications in near-shore environments as well as levee analysis. We discuss our design decisions and methodology for developing customized interfaces, strategies for delivery of the interfaces to users in various computing environments, as well as implications for the design/implementation of simulation models.

PVD thermal barrier coating applications and process development for aircraft engines

NASA Astrophysics Data System (ADS)

Rigney, D. V.; Viguie, R.; Wortman, D. J.; Skelly, D. W.

1997-06-01

Thermal barrier coatings (TBCs) have been developed for application to aircraft engine components to improve service life in an increasingly hostile thermal environment. The choice of TBC type is related to the component, intended use, and economics. Selection of electron beam physical vapor deposition proc-essing for turbine blade is due in part to part size, surface finish requirements, thickness control needs, and hole closure issues. Process development of PVD TBCs has been carried out at several different sites, including GE Aircraft Engines (GEAE). The influence of processing variables on microstructure is dis-cussed, along with the GEAE development coater and initial experiences of pilot line operation.

Technology-based suicide prevention: current applications and future directions.

PubMed

Luxton, David D; June, Jennifer D; Kinn, Julie T

2011-01-01

This review reports on current and emerging technologies for suicide prevention. Technology-based programs discussed include interactive educational and social networking Web sites, e-mail outreach, and programs that use mobile devices and texting. We describe innovative applications such as virtual worlds, gaming, and text analysis that are currently being developed and applied to suicide prevention and outreach programs. We also discuss the benefits and limitations of technology-based applications and discuss future directions for their use.

Gap model development, validation, and application to succession of secondary subtropical dry forests of Puerto Rico

Treesearch

Jennifer A. Holm; H.H. Shugart; Skip J. Van Bloem; G.R. Larocque

2012-01-01

Because of human pressures, the need to understand and predict the long-term dynamics and development of subtropical dry forests is urgent. Through modifications to the ZELIG simulation model, including the development of species- and site-specific parameters and internal modifications, the capability to model and predict forest change within the 4500-ha Guanica State...

Web services in the U.S. geological survey streamstats web application

USGS Publications Warehouse

Guthrie, J.D.; Dartiguenave, C.; Ries, Kernell G.

2009-01-01

StreamStats is a U.S. Geological Survey Web-based GIS application developed as a tool for waterresources planning and management, engineering design, and other applications. StreamStats' primary functionality allows users to obtain drainage-basin boundaries, basin characteristics, and streamflow statistics for gaged and ungaged sites. Recently, Web services have been developed that provide the capability to remote users and applications to access comprehensive GIS tools that are available in StreamStats, including delineating drainage-basin boundaries, computing basin characteristics, estimating streamflow statistics for user-selected locations, and determining point features that coincide with a National Hydrography Dataset (NHD) reach address. For the state of Kentucky, a web service also has been developed that provides users the ability to estimate daily time series of drainage-basin average values of daily precipitation and temperature. The use of web services allows the user to take full advantage of the datasets and processes behind the Stream Stats application without having to develop and maintain them. ?? 2009 IEEE.

Development by Design in Colombia: Making Mitigation Decisions Consistent with Conservation Outcomes

PubMed Central

Saenz, Shirley; Walschburger, Tomas; González, Juan Carlos; León, Jorge; McKenney, Bruce; Kiesecker, Joseph

2013-01-01

Mitigation policy and regulatory frameworks are consistent in their strong support for the mitigation hierarchy of: (1) avoiding impacts, (2) minimizing impacts, and then (3) offsetting/compensating for residual impacts. While mitigation frameworks require developers to avoid, minimize and restore biodiversity on-site before considering an offset for residual impacts, there is a lack of quantitative guidance for this decision-making process. What are the criteria for requiring impacts be avoided altogether? Here we examine how conservation planning can guide the application of the mitigation hierarchy to address this issue. In support of the Colombian government's aim to improve siting and mitigation practices for planned development, we examined five pilot projects in landscapes expected to experience significant increases in mining, petroleum and/or infrastructure development. By blending landscape-level conservation planning with application of the mitigation hierarchy, we can proactively identify where proposed development and conservation priorities would be in conflict and where impacts should be avoided. The approach we outline here has been adopted by the Colombian Ministry of Environment and Sustainable Development to guide licensing decisions, avoid piecemeal licensing, and promote mitigation decisions that maintain landscape condition. PMID:24339972

Development by design in Colombia: making mitigation decisions consistent with conservation outcomes.

PubMed

Saenz, Shirley; Walschburger, Tomas; González, Juan Carlos; León, Jorge; McKenney, Bruce; Kiesecker, Joseph

2013-01-01

Mitigation policy and regulatory frameworks are consistent in their strong support for the mitigation hierarchy of: (1) avoiding impacts, (2) minimizing impacts, and then (3) offsetting/compensating for residual impacts. While mitigation frameworks require developers to avoid, minimize and restore biodiversity on-site before considering an offset for residual impacts, there is a lack of quantitative guidance for this decision-making process. What are the criteria for requiring impacts be avoided altogether? Here we examine how conservation planning can guide the application of the mitigation hierarchy to address this issue. In support of the Colombian government's aim to improve siting and mitigation practices for planned development, we examined five pilot projects in landscapes expected to experience significant increases in mining, petroleum and/or infrastructure development. By blending landscape-level conservation planning with application of the mitigation hierarchy, we can proactively identify where proposed development and conservation priorities would be in conflict and where impacts should be avoided. The approach we outline here has been adopted by the Colombian Ministry of Environment and Sustainable Development to guide licensing decisions, avoid piecemeal licensing, and promote mitigation decisions that maintain landscape condition.

Remediation techniques for heavy metal-contaminated soils: Principles and applicability.

PubMed

Liu, Lianwen; Li, Wei; Song, Weiping; Guo, Mingxin

2018-08-15

Globally there are over 20millionha of land contaminated by the heavy metal(loid)s As, Cd, Cr, Hg, Pb, Co, Cu, Ni, Zn, and Se, with the present soil concentrations higher than the geo-baseline or regulatory levels. In-situ and ex-situ remediation techniques have been developed to rectify the heavy metal-contaminated sites, including surface capping, encapsulation, landfilling, soil flushing, soil washing, electrokinetic extraction, stabilization, solidification, vitrification, phytoremediation, and bioremediation. These remediation techniques employ containment, extraction/removal, and immobilization mechanisms to reduce the contamination effects through physical, chemical, biological, electrical, and thermal remedy processes. These techniques demonstrate specific advantages, disadvantages, and applicability. In general, in-situ soil remediation is more cost-effective than ex-situ treatment, and contaminant removal/extraction is more favorable than immobilization and containment. Among the available soil remediation techniques, electrokinetic extraction, chemical stabilization, and phytoremediation are at the development stage, while the others have been practiced at full, field scales. Comprehensive assessment indicates that chemical stabilization serves as a temporary soil remediation technique, phytoremediation needs improvement in efficiency, surface capping and landfilling are applicable to small, serious-contamination sites, while solidification and vitrification are the last remediation option. The cost and duration of soil remediation are technique-dependent and site-specific, up to $500ton -1 soil (or $1500m -3 soil or $100m -2 land) and 15years. Treatability studies are crucial to selecting feasible techniques for a soil remediation project, with considerations of the type and degree of contamination, remediation goals, site characteristics, cost effectiveness, implementation time, and public acceptability. Copyright © 2018 Elsevier B.V. All rights reserved.

From Excavations to Web: a GIS for Archaeology

NASA Astrophysics Data System (ADS)

D'Urso, M. G.; Corsi, E.; Nemeti, S.; Germani, M.

2017-05-01

The study and the protection of Cultural Heritage in recent years have undergone a revolution about the search tools and the reference disciplines. The technological approach to the problem of the collection, organization and publication of archaeological data using GIS software has completely changed the essence of the traditional methods of investigation, paving the way to the development of several application areas, up to the Cultural Resource Management. A relatively recent specific sector of development for archaeological GIS development sector is dedicated to the intra - site analyses aimed to recording, processing and display information obtained during the excavations. The case - study of the archaeological site located in the south - east of San Pietro Vetere plateau in Aquino, in the Southern Lazio, is concerned with the illustration of a procedure describing the complete digital workflow relative to an intra-site analysis of an archaeological dig. The GIS project implementation and its publication on the web, thanks to several softwares, particularly the FOSS (Free Open Source Software) Quantum - GIS, are an opportunity to reflect on the strengths and the critical nature of this particular application of the GIS technology. For future developments in research it is of fundamental importance the identification of a digital protocol for processing of excavations (from the acquisition, cataloguing, up data insertion), also on account of a possible future Open Project on medieval Aquino.

Assessing slope stability in unplanned settlements in developing countries.

PubMed

Anderson, Malcolm G; Holcombe, Liz; Renaud, Jean-Philippe

2007-10-01

Unplanned housing in developing countries is often located on steep slopes. Frequently no building code is enforced for such housing and mains water is provided with no drainage provision. Both of these factors can be particularly significant in terms of landslide risk if, as is so often the case, such slopes lack any planned drainage provision. There is thus a need to develop a model that facilitates the assessment of slope stability in an holistic context, incorporating a wide range of factors (including surface cover, soil water topographic convergence, slope loading and point source water leakage) in order that appropriate advice can be given as to the general controls on slope stability in such circumstances. This paper outlines a model configured for this specific purpose and describes an application to a site in St. Lucia, West Indies, where there is active slope movement in an unplanned housing development on relatively steep topography. The model findings are in accord with the nature of the current failure at the site, provide guidance as to the significance of slope drainage and correspond to inferences drawn from an application of resistance envelope methods to the site. In being able to scenario test a uniquely wide range of combinations of factors, the model structure is shown to be highly valuable in assessing dominant slope stability process controls in such complex environments.

Characteristics of experiential education web sites of US colleges and schools of pharmacy.

PubMed

Rodgers, Philip T; Leadon, Kim

2013-06-12

To evaluate the characteristics of experiential education Web sites of colleges and schools of pharmacy in the United States. The experiential education Web pages of 124 US colleges and schools of pharmacy were reviewed for office or program name, practice experience management software, experiential education newsletter, practice experience manual, preceptor development programs, new preceptor application processes, and interactive Web site interfaces. The term "office of experiential education" was used by 27.4% of colleges and schools. Fifty percent of the colleges and schools used E-value as their practice experience management software. Only a minority of colleges and schools made experiential manual(s) available online, offered newsletters targeted to preceptors, and/or provided Web site interactive interfaces for preceptor communication. The Preceptors Training and Resource Network was the preceptor development program most frequently promoted. The majority of US colleges and schools of pharmacy have official Web sites for their experiential education program; however, few offer resources online or use interactive or social media to their advantage.

Solar heating and cooling system design and development

NASA Technical Reports Server (NTRS)

1978-01-01

The development of eight prototype solar heating and combined heating and cooling systems is reported. Manufacture, test, installation, maintenance, problem resolution, and monitoring the operation of prototype systems is included. Heating and cooling equipment for single family residential and commercial applications and eight operational test sites (four heating and four heating and cooling) is described.

Building a data set over 12 globally distributed sites to support the development of agriculture monitoring applications with Sentinel-2

USDA-ARS?s Scientific Manuscript database

Developing better agricultural monitoring capabilities based on Earth Observation data is critical for strengthening food production information and market transparency. The coming Sentinel-2 mission has the optimal capacity for regional to global agriculture monitoring in terms of resolution (10-20...

Potential effects of existing and proposed groundwater withdrawals on water levels and natural groundwater discharge in Snake Valley and surrounding areas, Utah and Nevada

USGS Publications Warehouse

Masbruch, Melissa D.; Brooks, Lynette E.

2017-04-14

Several U.S. Department of Interior (DOI) agencies are concerned about the cumulative effects of groundwater development on groundwater resources managed by, and other groundwater resources of interest to, these agencies in Snake Valley and surrounding areas. The new water uses that potentially concern the DOI agencies include 12 water-right applications filed in 2005, totaling approximately 8,864 acre-feet per year. To date, only one of these applications has been approved and partially developed. In addition, the DOI agencies are interested in the potential effects of three new water-right applications (UT 18-756, UT 18-758, and UT 18-759) and one water-right change application (UT a40687), which were the subject of a water-right hearing on April 19, 2016.This report presents a hydrogeologic analysis of areas in and around Snake Valley to assess potential effects of existing and future groundwater development on groundwater resources, specifically groundwater discharge sites, of interest to the DOI agencies. A previously developed steady-state numerical groundwater-flow model was modified to transient conditions with respect to well withdrawals and used to quantify drawdown and capture (withdrawals that result in depletion) of natural discharge from existing and proposed groundwater withdrawals. The original steady-state model simulates and was calibrated to 2009 conditions. To investigate the potential effects of existing and proposed groundwater withdrawals on the groundwater resources of interest to the DOI agencies, 10 withdrawal scenarios were simulated. All scenarios were simulated for periods of 5, 10, 15, 30, 55, and 105 years from the start of 2010; additionally, all scenarios were simulated to a new steady state to determine the ultimate long-term effects of the withdrawals. Capture maps were also constructed as part of this analysis. The simulations used to develop the capture maps test the response of the system, specifically the reduction of natural discharge, to future stresses at a point in the area represented by the model. In this way, these maps can be used as a tool to determine the source of water to, and potential effects at specific areas from, future well withdrawals.Downward trends in water levels measured in wells indicate that existing groundwater withdrawals in Snake Valley are affecting water levels. The numerical model simulates similar downward trends in water levels; simulated drawdowns in the model, however, are generally less than observed water-level declines. At the groundwater discharge sites of interest to the DOI agencies, simulated drawdowns from existing well withdrawals (projected into the future) range from 0 to about 50 feet. Following the addition of the proposed withdrawals, simulated drawdowns at some sites increase by 25 feet. Simulated drawdown resulting from the proposed withdrawals began in as few as 5 years after 2014 at several of the sites. At the groundwater discharge sites of interest to the DOI agencies, simulated capture of natural discharge resulting from the existing withdrawals ranged from 0 to 87 percent. Following the addition of the proposed withdrawals, simulated capture at several of the sites reached 100 percent, indicating that groundwater discharge at that site would cease. Simulated capture following the addition of the proposed withdrawals increased in as few as 5 years after 2014 at several of the sites.

The NIH BD2K center for big data in translational genomics

PubMed Central

Paten, Benedict; Diekhans, Mark; Druker, Brian J; Friend, Stephen; Guinney, Justin; Gassner, Nadine; Guttman, Mitchell; James Kent, W; Mantey, Patrick; Margolin, Adam A; Massie, Matt; Novak, Adam M; Nothaft, Frank; Pachter, Lior; Patterson, David; Smuga-Otto, Maciej; Stuart, Joshua M; Van’t Veer, Laura; Haussler, David

2015-01-01

The world’s genomics data will never be stored in a single repository – rather, it will be distributed among many sites in many countries. No one site will have enough data to explain genotype to phenotype relationships in rare diseases; therefore, sites must share data. To accomplish this, the genetics community must forge common standards and protocols to make sharing and computing data among many sites a seamless activity. Through the Global Alliance for Genomics and Health, we are pioneering the development of shared application programming interfaces (APIs) to connect the world’s genome repositories. In parallel, we are developing an open source software stack (ADAM) that uses these APIs. This combination will create a cohesive genome informatics ecosystem. Using containers, we are facilitating the deployment of this software in a diverse array of environments. Through benchmarking efforts and big data driver projects, we are ensuring ADAM’s performance and utility. PMID:26174866

Application of NMR Methods to Identify Detection Reagents for Use in the Development of Robust Nanosensors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cosman, M; Krishnan, V V; Balhorn, R

2004-04-29

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique for studying bi-molecular interactions at the atomic scale. Our NMR lab is involved in the identification of small molecules, or ligands that bind to target protein receptors, such as tetanus (TeNT) and botulinum (BoNT) neurotoxins, anthrax proteins and HLA-DR10 receptors on non-Hodgkin's lymphoma cancer cells. Once low affinity binders are identified, they can be linked together to produce multidentate synthetic high affinity ligands (SHALs) that have very high specificity for their target protein receptors. An important nanotechnology application for SHALs is their use in the development of robust chemical sensors ormore » biochips for the detection of pathogen proteins in environmental samples or body fluids. Here, we describe a recently developed NMR competition assay based on transferred nuclear Overhauser effect spectroscopy (trNOESY) that enables the identification of sets of ligands that bind to the same site, or a different site, on the surface of TeNT fragment C (TetC) than a known ''marker'' ligand, doxorubicin. Using this assay, we can identify the optimal pairs of ligands to be linked together for creating detection reagents, as well as estimate the relative binding constants for ligands competing for the same site.« less

75 FR 69458 - Notice of Draft NIJ Law Enforcement Duty Holster Selection and Application Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-12

... and organizations, research, development and scientific communities, and all other stakeholders and... consideration are directed to the following Web site: http://www.justnet.org . DATES: Comments must be received...

RECEPTOR MODEL DEVELOPMENT AND APPLICATION

EPA Science Inventory

Source apportionment (receptor) models are mathematical procedures for identifying and quantifying the sources of ambient air pollutants and their effects at a site (the receptor), primarily on the basis of species concentration measurements at the receptor, and generally without...

78 FR 13904 - Notice of Availability of Funds and Solicitation for Grant Applications for Intermediary...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-01

... to operate multi-site projects to serve juvenile offenders and in-school youth at-risk of involvement... development, education and training, case management, mentoring, restorative justice, community- wide violence...

10 CFR 100.21 - Non-seismic siting criteria.

Code of Federal Regulations, 2011 CFR

2011-01-01

... NUCLEAR REGULATORY COMMISSION (CONTINUED) REACTOR SITE CRITERIA Evaluation Factors for Stationary Power Reactor Site Applications on or After January 10, 1997 § 100.21 Non-seismic siting criteria. Applications for site approval for commercial power reactors shall demonstrate that the proposed site meets the...

10 CFR 100.21 - Non-seismic siting criteria.

Code of Federal Regulations, 2010 CFR

2010-01-01

... NUCLEAR REGULATORY COMMISSION (CONTINUED) REACTOR SITE CRITERIA Evaluation Factors for Stationary Power Reactor Site Applications on or After January 10, 1997 § 100.21 Non-seismic siting criteria. Applications for site approval for commercial power reactors shall demonstrate that the proposed site meets the...

Characterizing phosphorus dynamics in tile-drained agricultural fieldsof eastern Wisconsin

USGS Publications Warehouse

Madison, Allison; Ruark, Matthew; Stuntebeck, Todd D.; Komiskey, Matthew J.; Good, Laura W.; Drummy, Nancy; Cooley, Eric

2014-01-01

Artificial subsurface drainage provides an avenue for the rapid transfer of phosphorus (P) from agricultural fields to surface waters. This is of particular interest in eastern Wisconsin, where there is a concentrated population of dairy farms and high clay content soils prone to macropore development. Through collaboration with private landowners, surface and tile drainage was measured and analyzed for dissolved reactive P (DRP) and total P (TP) losses at four field sites in eastern Wisconsin between 2005 and 2009. These sites, which received frequent manure applications, represent a range of crop management practices which include: two chisel plowed corn fields (CP1, CP2), a no-till corn–soybean field (NT), and a grazed pasture (GP). Subsurface drainage was the dominant pathway of water loss at each site accounting for 66–96% of total water discharge. Average annual flow-weighted (FW) TP concentrations were 0.88, 0.57, 0.21, and 1.32 mg L−1 for sites CP1, CP2, NT, and GP, respectively. Low TP concentrations at the NT site were due to tile drain interception of groundwater flow where large volumes of tile drainage water diluted the FW-TP concentrations. Subsurface pathways contributed between 17% and 41% of the TP loss across sites. On a drainage event basis, total drainage explained between 36% and 72% of the event DRP loads across CP1, CP2, and GP; there was no relationship between event drainflow and event DRP load at the NT site. Manure applications did not consistently increase P concentrations in drainflow, but annual FW-P concentrations were greater in years receiving manure applications compared to years without manure application. Based on these field measures, P losses from tile drainage must be integrated into field level P budgets and P loss calculations on heavily manured soils, while also acknowledging the unique drainage patterns observed in eastern Wisconsin.

Characterizing phosphorus dynamics in tile-drained agricultural fields of eastern Wisconsin

NASA Astrophysics Data System (ADS)

Madison, Allison M.; Ruark, Matthew D.; Stuntebeck, Todd D.; Komiskey, Matthew J.; Good, Lara W.; Drummy, Nancy; Cooley, Eric T.

2014-11-01

Artificial subsurface drainage provides an avenue for the rapid transfer of phosphorus (P) from agricultural fields to surface waters. This is of particular interest in eastern Wisconsin, where there is a concentrated population of dairy farms and high clay content soils prone to macropore development. Through collaboration with private landowners, surface and tile drainage was measured and analyzed for dissolved reactive P (DRP) and total P (TP) losses at four field sites in eastern Wisconsin between 2005 and 2009. These sites, which received frequent manure applications, represent a range of crop management practices which include: two chisel plowed corn fields (CP1, CP2), a no-till corn-soybean field (NT), and a grazed pasture (GP). Subsurface drainage was the dominant pathway of water loss at each site accounting for 66-96% of total water discharge. Average annual flow-weighted (FW) TP concentrations were 0.88, 0.57, 0.21, and 1.32 mg L-1 for sites CP1, CP2, NT, and GP, respectively. Low TP concentrations at the NT site were due to tile drain interception of groundwater flow where large volumes of tile drainage water diluted the FW-TP concentrations. Subsurface pathways contributed between 17% and 41% of the TP loss across sites. On a drainage event basis, total drainage explained between 36% and 72% of the event DRP loads across CP1, CP2, and GP; there was no relationship between event drainflow and event DRP load at the NT site. Manure applications did not consistently increase P concentrations in drainflow, but annual FW-P concentrations were greater in years receiving manure applications compared to years without manure application. Based on these field measures, P losses from tile drainage must be integrated into field level P budgets and P loss calculations on heavily manured soils, while also acknowledging the unique drainage patterns observed in eastern Wisconsin.

Development of Commercial Thermo-sensitive Genic Male Sterile Rice Accelerates Hybrid Rice Breeding Using the CRISPR/Cas9-mediated TMS5 Editing System

PubMed Central

Zhou, Hai; He, Ming; Li, Jing; Chen, Liang; Huang, Zhifeng; Zheng, Shaoyan; Zhu, Liya; Ni, Erdong; Jiang, Dagang; Zhao, Bingran; Zhuang, Chuxiong

2016-01-01

Hybrid rice breeding offers an important strategy to improve rice production, in which the cultivation of a male sterile line is the key to the success of cross-breeding. CRISPR/Cas9 systems have been widely used in target-site genome editing, whereas their application for crop genetic improvement has been rarely reported. Here, using the CRISPR/Cas9 system, we induced specific mutations in TMS5, which is the most widely applied thermo-sensitive genic male sterility (TGMS) gene in China, and developed new “transgene clean” TGMS lines. We designed 10 target sites in the coding region of TMS5 for targeted mutagenesis using the CRISPR/Cas9 system and assessed the potential rates of on- and off-target effects. Finally, we established the most efficient construct, the TMS5ab construct, for breeding potentially applicable “transgene clean” TGMS lines. We also discussed factors that affect the editing efficiency according to the characteristics of different target sequences. Notably, using the TMS5ab construct, we developed 11 new “transgene clean” TGMS lines with potential applications in hybrid breeding within only one year in both rice subspecies. The application of our system not only significantly accelerates the breeding of sterile lines but also facilitates the exploitation of heterosis. PMID:27874087

Application of Remote Sensing and GIS in Landfill (waste Disposal) Site Selection and Environmental Impacts Assessment around Mysore City, Karnataka, India

NASA Astrophysics Data System (ADS)

Basavarajappa, T. H.

2012-07-01

Landfill site selection is a complex process involving geological, hydrological, environmental and technical parameters as well as government regulations. As such, it requires the processing of a good amount of geospatial data. Landfill site selection techniques have been analyzed for identifying their suitability. Application of Geographic Information System (GIS) is suitable to find best locations for such installations which use multiple criteria analysis. The use of Artificial intelligence methods, such as expert systems, can also be very helpful in solid waste planning and management. The waste disposal and its pollution around major cities in Karnataka are important problems affecting the environment. The Mysore is one of the major cities in Karnataka. The landfill site selection is the best way to control of pollution from any region. The main aim is to develop geographic information system to study the Landuse/ Landcover, natural drainage system, water bodies, and extents of villages around Mysore city, transportation, topography, geomorphology, lithology, structures, vegetation and forest information for landfill site selection. GIS combines spatial data (maps, aerial photographs, and satellite images) with quantitative, qualitative, and descriptive information database, which can support a wide range of spatial queries. For the Site Selection of an industrial waste and normal daily urban waste of a city town or a village, combining GIS with Analytical Hierarchy Process (AHP) will be more appropriate. This method is innovative because it establishes general indices to quantify overall environmental impact as well as individual indices for specific environmental components (i.e. surface water, groundwater, atmosphere, soil and human health). Since this method requires processing large quantities of spatial data. To automate the processes of establishing composite evaluation criteria, performing multiple criteria analysis and carrying out spatial clustering a suitable methodology was developed. The feasibility of site selection in the study area based on different criteria was used to obtain the layered data by integrating Remote Sensing and GIS. This methodology is suitable for all practical applications in other cities, also.

Application of Crunch-Flow Routines to Constrain Present and Past Carbon Fluxes at Gas-Hydrate Bearing Sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Torres, Marta

2014-01-31

In November 2012, Oregon State University initiated the project entitled: Application of Crunch-Flow routines to constrain present and past carbon fluxes at gas-hydrate bearing sites. Within this project we developed Crunch-Flow based modeling modules that include important biogeochemical processes that need to be considered in gas hydrate environments. Our modules were applied to quantify carbon cycling in present and past systems, using data collected during several DOE-supported drilling expeditions, which include the Cascadia margin in US, Ulleung Basin in South Korea, and several sites drilled offshore India on the Bay of Bengal and Andaman Sea. Specifically, we completed modeling effortsmore » that: 1) Reproduce the compositional and isotopic profiles observed at the eight drilled sites in the Ulleung Basin that constrain and contrast the carbon cycling pathways at chimney (high methane flux) and non-chimney sites (low methane, advective systems); 2) Simulate the Ba record in the sediments to quantify the past dynamics of methane flux in the southern Hydrate Ridge, Cascadia margin; and 3) Provide quantitative estimates of the thickness of individual mass transport deposits (MTDs), time elapsed after the MTD event, rate of sulfate reduction in the MTD, and time required to reach a new steady state at several sites drilled in the Krishna-Godavari (K-G) Basin off India. In addition we developed a hybrid model scheme by coupling a home-made MATLAB code with CrunchFlow to address the methane transport and chloride enrichment at the Ulleung Basins chimney sites, and contributed the modeling component to a study focusing on pore-scale controls on gas hydrate distribution in sediments from the Andaman Sea. These efforts resulted in two manuscripts currently under review, and contributed the modeling component of another pare, also under review. Lessons learned from these efforts are the basis of a mini-workshop to be held at Oregon State University (Feb 2014) to instruct graduate students (OSU and UW) as well as DOE staff from the NETL lab in Albany on the use of Crunch Flow for geochemical applications.« less

Steering operational synergies in terrestrial observation networks: opportunity for advancing Earth system dynamics modelling

NASA Astrophysics Data System (ADS)

Baatz, Roland; Sullivan, Pamela L.; Li, Li; Weintraub, Samantha R.; Loescher, Henry W.; Mirtl, Michael; Groffman, Peter M.; Wall, Diana H.; Young, Michael; White, Tim; Wen, Hang; Zacharias, Steffen; Kühn, Ingolf; Tang, Jianwu; Gaillardet, Jérôme; Braud, Isabelle; Flores, Alejandro N.; Kumar, Praveen; Lin, Henry; Ghezzehei, Teamrat; Jones, Julia; Gholz, Henry L.; Vereecken, Harry; Van Looy, Kris

2018-05-01

Advancing our understanding of Earth system dynamics (ESD) depends on the development of models and other analytical tools that apply physical, biological, and chemical data. This ambition to increase understanding and develop models of ESD based on site observations was the stimulus for creating the networks of Long-Term Ecological Research (LTER), Critical Zone Observatories (CZOs), and others. We organized a survey, the results of which identified pressing gaps in data availability from these networks, in particular for the future development and evaluation of models that represent ESD processes, and provide insights for improvement in both data collection and model integration. From this survey overview of data applications in the context of LTER and CZO research, we identified three challenges: (1) widen application of terrestrial observation network data in Earth system modelling, (2) develop integrated Earth system models that incorporate process representation and data of multiple disciplines, and (3) identify complementarity in measured variables and spatial extent, and promoting synergies in the existing observational networks. These challenges lead to perspectives and recommendations for an improved dialogue between the observation networks and the ESD modelling community, including co-location of sites in the existing networks and further formalizing these recommendations among these communities. Developing these synergies will enable cross-site and cross-network comparison and synthesis studies, which will help produce insights around organizing principles, classifications, and general rules of coupling processes with environmental conditions.

Methodology of management of dredging operations II. Applications.

PubMed

Junqua, G; Abriak, N E; Gregoire, P; Dubois, V; Mac Farlane, F; Damidot, D

2006-04-01

This paper presents the new methodology of management of dredging operations. Derived partly from existing methodologies (OECD, PNUE, AIPCN), it aims to be more comprehensive, mixing the qualities and the complementarities of previous methodologies. The application of the methodology has been carried out on the site of the Port of Dunkirk (FRANCE). Thus, a characterization of the sediments of this site has allowed a zoning of the Port to be established in to zones of probable homogeneity of sediments. Moreover, sources of pollution have been identified, with an aim of prevention. Ways of waste improvement have also been developed, to answer regional needs, from a point of view of competitive and territorial intelligence. Their development has required a mutualisation of resources between professionals, research centres and local communities, according to principles of industrial ecology. Lastly, a tool of MultiCriteria Decision-Making Aid (M.C.D.M.A.) has been used to determine the most relevant scenario (or alternative, or action) for a dredging operation intended by the Port of Dunkirk. These applications have confirmed the relevance of this methodology for the management of dredging operations.

Thermal power systems, small power systems application project. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Marriott, A. T.

1979-01-01

Current small power system technology as applied to power plants up to 10 MWe in size was assessed. Markets for small power systems were characterized and cost goals were established. Candidate power plant system design concepts were selected for evaluation and preliminary performance and cost assessments were made. Economic studies were conducted and breakeven capital costs were determined for leading contenders among the candidate systems. An application study was made of the potential use of small power systems in providing part of the demand for pumping power by the extensive aqueduct system of California, estimated to be 1000 MWe by 1985. Criteria and methodologies were developed for application to the ranking of candidate power plant system design concepts. Experimental power plants concepts of 1 MWe rating were studied leading toward the definition of a power plant configuration for subsequent detail design, construction, testing and evaluation as Engineering Experiment No. 1 (EE No. 1). Site selection criteria and ground rules for the solicitation of EE No. 1 site participation proposals by DOE were developed.

Smart textiles: a new drug delivery system for symptomatic treatment of a common cold.

PubMed

Wienforth, F; Landrock, A; Schindler, C; Siegert, J; Kirch, W

2007-05-01

Smart textiles provide the possibility of being coated with cineole, menthol, and camphor. Due to over-the-counter availability, ethereal oils are frequently used to treat a common cold. The existing pharmaceutical forms entail the risk of oral ingestion by children, which can cause severe intoxications. This risk could be limited by a smart textile application. Prior to applicability tests in children, the principal traceability of smart textile-applied ethereal oils at their site of action in the alveoli has to be demonstrated. Therefore, a crossover trial (ointment vs smart textiles) with 6 healthy volunteers was carried out as a proof-of-concept study. As a result, the principle proof is given that smart textile-applied ethereal oils are available at their site of action. Because of the volatility of the active ingredients, a close-fitting textile form has to be developed for further clinical development of smart textiles to achieve higher concentrations in the alveoli. Slower liberation properties and a more convenient skin sensation in comparison to available pharmaceutical forms may provide advantages for the applicability in both children and adults.

77 FR 8806 - Foreign-Trade Zone 183-Austin, TX; Application for Reorganization Under the Alternative Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... Gardner Road, Austin; Site 2 (50 acres)--Balcones Research site located in north central Austin at the... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Docket 8-2012] Foreign-Trade Zone 183--Austin, TX; Application for Reorganization Under the Alternative Site Framework An application has been...

Regional regression equations to estimate peak-flow frequency at sites in North Dakota using data through 2009

USGS Publications Warehouse

Williams-Sether, Tara

2015-08-06

Annual peak-flow frequency data from 231 U.S. Geological Survey streamflow-gaging stations in North Dakota and parts of Montana, South Dakota, and Minnesota, with 10 or more years of unregulated peak-flow record, were used to develop regional regression equations for exceedance probabilities of 0.5, 0.20, 0.10, 0.04, 0.02, 0.01, and 0.002 using generalized least-squares techniques. Updated peak-flow frequency estimates for 262 streamflow-gaging stations were developed using data through 2009 and log-Pearson Type III procedures outlined by the Hydrology Subcommittee of the Interagency Advisory Committee on Water Data. An average generalized skew coefficient was determined for three hydrologic zones in North Dakota. A StreamStats web application was developed to estimate basin characteristics for the regional regression equation analysis. Methods for estimating a weighted peak-flow frequency for gaged sites and ungaged sites are presented.

Peacetime Innovation and the U.S. Army Corps of Engineers: Managing Technology for Industrial Application

DTIC Science & Technology

1993-02-04

be done by using the corps’ organic construction management assets at contaminated military sites in a test bed or incubator fashion to hedge high ...wastes at military sites is introduced to highlight its efficacy in developing high risk, high payoff remediation techrhologies. A number of...investment. Exposure to potential litigation makes such ventures nearly impossible. Small contractors attempting to penetrate the market with innovative

Processing plutonium-contaminated soil on Johnston Atoll

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moroney, K.; Moroney, J. III; Turney, J.

1994-07-01

This article describes a cleanup project to process plutonium- and americium-contaminated soil on Johnston Atoll for volume reduction. Thermo Analytical`s (TMA`s) segmented gate system (SGS) for this remedial operation has been in successful on-site operation since 1992. Topics covered include the basis for development, a description of the Johnston Atoll; the significance of results; the benefits of the technology; applicability to other radiologically contaminated sites. 7 figs., 1 tab.

Site-Specific Genome Engineering in Human Pluripotent Stem Cells.

PubMed

Merkert, Sylvia; Martin, Ulrich

2016-06-24

The possibility to generate patient-specific induced pluripotent stem cells (iPSCs) offers an unprecedented potential of applications in clinical therapy and medical research. Human iPSCs and their differentiated derivatives are tools for diseases modelling, drug discovery, safety pharmacology, and toxicology. Moreover, they allow for the engineering of bioartificial tissue and are promising candidates for cellular therapies. For many of these applications, the ability to genetically modify pluripotent stem cells (PSCs) is indispensable, but efficient site-specific and safe technologies for genetic engineering of PSCs were developed only recently. By now, customized engineered nucleases provide excellent tools for targeted genome editing, opening new perspectives for biomedical research and cellular therapies.

Development of the SAFE Checklist Tool for Assessing Site-Level Threats to Child Protection: Use of Delphi Methods and Application to Two Sites in India

PubMed Central

Betancourt, Theresa S.; Zuilkowski, Stephanie S.; Ravichandran, Arathi; Einhorn, Honora; Arora, Nikita; Bhattacharya Chakravarty, Aruna; Brennan, Robert T.

2015-01-01

Background The child protection community is increasingly focused on developing tools to assess threats to child protection and the basic security needs and rights of children and families living in adverse circumstances. Although tremendous advances have been made to improve measurement of individual child health status or household functioning for use in low-resource settings, little attention has been paid to a more diverse array of settings in which many children in adversity spend time and how context contributes to threats to child protection. The SAFE model posits that insecurity in any of the following fundamental domains threatens security in the others: Safety/freedom from harm; Access to basic physiological needs and healthcare; Family and connection to others; Education and economic security. Site-level tools are needed in order to monitor the conditions that can dramatically undermine or support healthy child growth, development and emotional and behavioral health. From refugee camps and orphanages to schools and housing complexes, site-level threats exist that are not well captured by commonly used measures of child health and well-being or assessments of single households (e.g., SDQ, HOME). Methods The present study presents a methodology and the development of a scale for assessing site-level child protection threats in various settings of adversity. A modified Delphi panel process was enhanced with two stages of expert review in core content areas as well as review by experts in instrument development, and field pilot testing. Results Field testing in two diverse sites in India—a construction site and a railway station—revealed that the resulting SAFE instrument was sensitive to the differences between the sites from the standpoint of core child protection issues. PMID:26540159

Development of the SAFE Checklist Tool for Assessing Site-Level Threats to Child Protection: Use of Delphi Methods and Application to Two Sites in India.

PubMed

Betancourt, Theresa S; Zuilkowski, Stephanie S; Ravichandran, Arathi; Einhorn, Honora; Arora, Nikita; Bhattacharya Chakravarty, Aruna; Brennan, Robert T

2015-01-01

The child protection community is increasingly focused on developing tools to assess threats to child protection and the basic security needs and rights of children and families living in adverse circumstances. Although tremendous advances have been made to improve measurement of individual child health status or household functioning for use in low-resource settings, little attention has been paid to a more diverse array of settings in which many children in adversity spend time and how context contributes to threats to child protection. The SAFE model posits that insecurity in any of the following fundamental domains threatens security in the others: Safety/freedom from harm; Access to basic physiological needs and healthcare; Family and connection to others; Education and economic security. Site-level tools are needed in order to monitor the conditions that can dramatically undermine or support healthy child growth, development and emotional and behavioral health. From refugee camps and orphanages to schools and housing complexes, site-level threats exist that are not well captured by commonly used measures of child health and well-being or assessments of single households (e.g., SDQ, HOME). The present study presents a methodology and the development of a scale for assessing site-level child protection threats in various settings of adversity. A modified Delphi panel process was enhanced with two stages of expert review in core content areas as well as review by experts in instrument development, and field pilot testing. Field testing in two diverse sites in India-a construction site and a railway station-revealed that the resulting SAFE instrument was sensitive to the differences between the sites from the standpoint of core child protection issues.

Pine growth following chemical site prep and postplant herbaceous weed control compared to chemical site prep only

Treesearch

Dwight K. Lauer; Harold E. Quicke

2013-01-01

Three site prep vegetation control systems were compared on two Piedmont and two Upper Coastal Plain sites. Systems were (1) a one-time site prep application of Chopper® GEN2™ 2, (2) a one-time application of Chopper® GEN2™ tank mixed with sulfometuron, and (3) two applications consisting of site prep with Chopper® GEN2™ followed by herbaceous weed control with Arsenal...

Inhibition of auxin movement from the shoot into the root inhibits lateral root development in Arabidopsis

NASA Technical Reports Server (NTRS)

Reed, R. C.; Brady, S. R.; Muday, G. K.

1998-01-01

In roots two distinct polar movements of auxin have been reported that may control different developmental and growth events. To test the hypothesis that auxin derived from the shoot and transported toward the root controls lateral root development, the two polarities of auxin transport were uncoupled in Arabidopsis. Local application of the auxin-transport inhibitor naphthylphthalamic acid (NPA) at the root-shoot junction decreased the number and density of lateral roots and reduced the free indoleacetic acid (IAA) levels in the root and [3H]IAA transport into the root. Application of NPA to the basal half of or at several positions along the root only reduced lateral root density in regions that were in contact with NPA or in regions apical to the site of application. Lateral root development was restored by application of IAA apical to NPA application. Lateral root development in Arabidopsis roots was also inhibited by excision of the shoot or dark growth and this inhibition was reversible by IAA. Together, these results are consistent with auxin transport from the shoot into the root controlling lateral root development.

Manipulating vineyard nitrogen on a saline site: 1. Effect of nitrogen on growth, grape yield and nutrients of Vitis vinifera L. cv Shiraz.

PubMed

Bell, Sally-Jean; Francis, I Leigh

2013-08-15

With increased prevalence of saline irrigation water applied to vines worldwide, the issue of appropriate nitrogen management is of concern. Different rates of nitrogen per vine as urea were applied to Shiraz vines on own roots over four seasons in a low-rainfall, saline growing environment. Application of nitrogen in the vineyard early in the season not only altered the vine nitrogen status but also increased some other elements in the petioles, notably chloride and sodium but also manganese and magnesium. In contrast, nitrogen application decreased petiole phosphorus. In comparison with the majority of nitrogen studies on non-saline sites, nitrogen-induced growth responses were restricted under the saline conditions in this study. While some changes in canopy density in response to nitrogen were observed, this did not affect light interception in the fruit zone. Yield responses were varied and could be related to the nutritional conditions under which bud development and flowering took place. This study demonstrated that current best practice guidelines, in terms of rate of nitrogen applied, for correcting a nitrogen deficiency on a non-saline site may not be appropriate for saline sites and that application of nitrogen can increase the potential for salt toxicity in vines. © 2013 Society of Chemical Industry.

Designing and developing portable large-scale JavaScript web applications within the Experiment Dashboard framework

NASA Astrophysics Data System (ADS)

Andreeva, J.; Dzhunov, I.; Karavakis, E.; Kokoszkiewicz, L.; Nowotka, M.; Saiz, P.; Tuckett, D.

2012-12-01

Improvements in web browser performance and web standards compliance, as well as the availability of comprehensive JavaScript libraries, provides an opportunity to develop functionally rich yet intuitive web applications that allow users to access, render and analyse data in novel ways. However, the development of such large-scale JavaScript web applications presents new challenges, in particular with regard to code sustainability and team-based work. We present an approach that meets the challenges of large-scale JavaScript web application design and development, including client-side model-view-controller architecture, design patterns, and JavaScript libraries. Furthermore, we show how the approach leads naturally to the encapsulation of the data source as a web API, allowing applications to be easily ported to new data sources. The Experiment Dashboard framework is used for the development of applications for monitoring the distributed computing activities of virtual organisations on the Worldwide LHC Computing Grid. We demonstrate the benefits of the approach for large-scale JavaScript web applications in this context by examining the design of several Experiment Dashboard applications for data processing, data transfer and site status monitoring, and by showing how they have been ported for different virtual organisations and technologies.

24 CFR 51.102 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... areas and advise local officials, developers, and planning groups of the unacceptability of sites... the suitability of the acoustical environment of proposed projects; (2) Notify applicants of any... acceptability standards in commenting on the prospective impacts of transportation facilities and other noise...

24 CFR 51.102 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... areas and advise local officials, developers, and planning groups of the unacceptability of sites... the suitability of the acoustical environment of proposed projects; (2) Notify applicants of any... acceptability standards in commenting on the prospective impacts of transportation facilities and other noise...

40 CFR 60.54b - Standards for municipal waste combustor operator training and certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... owner or operator of an affected facility shall develop and update on a yearly basis a site-specific... under this subpart; (2) A description of basic combustion theory applicable to a municipal waste...

40 CFR 62.14105 - Requirements for municipal waste combustor operator training and certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... operator of an affected facility must develop and update on a yearly basis a site-specific operating manual... subpart; (2) A description of basic combustion theory applicable to a municipal waste combustor unit; (3...

HABITAT MODELING APPROACHES FOR RESTORATION SITE SELECTION

EPA Science Inventory

Numerous modeling approaches have been used to develop predictive models of species-environment and species-habitat relationships. These models have been used in conservation biology and habitat or species management, but their application to restoration efforts has been minimal...

OSI Conformance Testing for Bibliographic Applications.

ERIC Educational Resources Information Center

Arbez, Gilbert; Swain, Leigh

1990-01-01

Describes the development of Open Systems Interconnection (OSI) conformance testing sites, conformance testing tools, and conformance testing services. Discusses related topics such as interoperability testing, arbitration testing, and international harmonization of conformance testing. A glossary is included. (24 references) (SD)

LANDSAT demonstration/application and GIS integration in south central Alaska

NASA Technical Reports Server (NTRS)

Burns, A. W.; Derrenbacher, W.

1981-01-01

Automated geographic information systems were developed for two sites in Southcentral Alaska to serve as tests for both the process of integrating classified LANDSAT data into a comprehensive environmental data base and the process of using automated information in land capability/suitability analysis and environmental planning. The Big Lake test site, located approximately 20 miles north of the City of Anchorage, comprises an area of approximately 150 square miles. The Anchorage Hillside test site, lying approximately 5 miles southeast of the central part of the city, extends over an area of some 25 square miles. Map construction and content is described.

Response of avian communities to herbicide-induced vegetation changes

USGS Publications Warehouse

Morrison, M.L.; Meslow, E.C.

1984-01-01

The relationships between avian communities and herbicide modification of vegetation were analyzed on early-growth clear-cuts in western Oregon that had received phenoxy herbicide treatment 1 or 4 years previously. For both 1 and 4 years post-spray, vegetation development was greater in the third height interval (> 3.0 m) on untreated sites. All measures of vegetative diversity on untreated sites exceeded those on treated sites. Overall density and diversity of birds were similar between treated and untreated sites. Several bird species altered their foraging behavior on treated sites, i.e., birds using deciduous trees increased use of shrubs on treated sites. The primary effect of herbicide application was a reduction in the complexity of vegetation, a condition due primarity to the removal of deciduous trees. Small patches of deciduous trees scattered in clear-cuts treated with phenoxy herbicides can maintain an avian community similar to that on untreated sites.

Construction of a high-density genetic map for grape using next generation restriction-site associated DNA sequencing

PubMed Central

2012-01-01

Background Genetic mapping and QTL detection are powerful methodologies in plant improvement and breeding. Construction of a high-density and high-quality genetic map would be of great benefit in the production of superior grapes to meet human demand. High throughput and low cost of the recently developed next generation sequencing (NGS) technology have resulted in its wide application in genome research. Sequencing restriction-site associated DNA (RAD) might be an efficient strategy to simplify genotyping. Combining NGS with RAD has proven to be powerful for single nucleotide polymorphism (SNP) marker development. Results An F1 population of 100 individual plants was developed. In-silico digestion-site prediction was used to select an appropriate restriction enzyme for construction of a RAD sequencing library. Next generation RAD sequencing was applied to genotype the F1 population and its parents. Applying a cluster strategy for SNP modulation, a total of 1,814 high-quality SNP markers were developed: 1,121 of these were mapped to the female genetic map, 759 to the male map, and 1,646 to the integrated map. A comparison of the genetic maps to the published Vitis vinifera genome revealed both conservation and variations. Conclusions The applicability of next generation RAD sequencing for genotyping a grape F1 population was demonstrated, leading to the successful development of a genetic map with high density and quality using our designed SNP markers. Detailed analysis revealed that this newly developed genetic map can be used for a variety of genome investigations, such as QTL detection, sequence assembly and genome comparison. PMID:22908993

The National Flood Frequency Program, version 3 : a computer program for estimating magnitude and frequency of floods for ungaged sites

USGS Publications Warehouse

Ries, Kernell G.; Crouse, Michele Y.

2002-01-01

For many years, the U.S. Geological Survey (USGS) has been developing regional regression equations for estimating flood magnitude and frequency at ungaged sites. These regression equations are used to transfer flood characteristics from gaged to ungaged sites through the use of watershed and climatic characteristics as explanatory or predictor variables. Generally, these equations have been developed on a Statewide or metropolitan-area basis as part of cooperative study programs with specific State Departments of Transportation. In 1994, the USGS released a computer program titled the National Flood Frequency Program (NFF), which compiled all the USGS available regression equations for estimating the magnitude and frequency of floods in the United States and Puerto Rico. NFF was developed in cooperation with the Federal Highway Administration and the Federal Emergency Management Agency. Since the initial release of NFF, the USGS has produced new equations for many areas of the Nation. A new version of NFF has been developed that incorporates these new equations and provides additional functionality and ease of use. NFF version 3 provides regression-equation estimates of flood-peak discharges for unregulated rural and urban watersheds, flood-frequency plots, and plots of typical flood hydrographs for selected recurrence intervals. The Program also provides weighting techniques to improve estimates of flood-peak discharges for gaging stations and ungaged sites. The information provided by NFF should be useful to engineers and hydrologists for planning and design applications. This report describes the flood-regionalization techniques used in NFF and provides guidance on the applicability and limitations of the techniques. The NFF software and the documentation for the regression equations included in NFF are available at http://water.usgs.gov/software/nff.html.

Consolidating a Distributed Compound Management Capability into a Single Installation: The Application of Overall Equipment Effectiveness to Determine Capacity Utilization.

PubMed

Green, Clive; Taylor, Daniel

2016-12-01

Compound management (CM) is a critical discipline enabling hit discovery through the production of assay-ready compound plates for screening. CM in pharma requires significant investments in manpower, capital equipment, repairs and maintenance, and information technology. These investments are at risk from external factors, for example, new technology rendering existing equipment obsolete and strategic site closures. At AstraZeneca, we faced the challenge of evaluating the number of CM sites required to support hit discovery in response to site closures and pressure on our operating budget. We reasoned that overall equipment effectiveness, a tool used extensively in the manufacturing sector, could determine the equipment capacity and appropriate number of sites. We identified automation downtime as the critical component governing capacity, and a connection between automation downtime and the availability of skilled staff. We demonstrated that sufficient production capacity existed in two sites to meet hit discovery demand without the requirement for an additional investment of $7 million in new facilities. In addition, we developed an automated capacity model that incorporated an extended working-day pattern as a solution for reducing automation downtime. The application of this solution enabled the transition to a single site, with an annual cost saving of $2.1 million. © 2015 Society for Laboratory Automation and Screening.

Mobile augmented reality applications for heritage preservation in UNESCO world heritage sites through adopting the UTAUT model

NASA Astrophysics Data System (ADS)

Shang, Low Wei; Siang, Tan Gek; Zakaria, Mohd Hafiz bin; Emran, Muhammad Helmy

2017-04-01

Augmented reality (AR) technology has undergone enormous advancement and now AR applications can be seamlessly executed using modern-day smartphones. This study aims to develop a mobile AR application which consists of 3D AR models of historical monuments located within the UNESCO World Heritage Site in Melaka. The application allows tourists to obtain information of the monuments from the AR models, which provide an alternative way of visiting the actual monuments to prevent overcrowding effect and promote heritage preservation. Perceived Usefulness (PU), Perceived Ease of Use (PEU), Facilitating Conditions (FC), and Perceived Playfulness (PP) are proposed as the determinants of user's Behavioural Intention to Use (BI) the application. Using 50 tourists in Melaka as respondents, a pilot study has been conducted to determine user's acceptance of the AR mobile application based on the Unified Theory of Acceptance and Use of Technology (UTAUT). Cronbach's Alpha test validated the internal consistency of the measures. Multiple Linear Regression analysis suggested that the proposed determinants explained 51.2% in user's BI the application. PU was the strongest determinant followed by FC while PEU and PP were found to be insignificant.

Performance Comparison of Systematic Methods for Rigorous Definition of Coarse-Grained Sites of Large Biomolecules.

PubMed

Zhang, Yuwei; Cao, Zexing; Zhang, John Zenghui; Xia, Fei

2017-02-27

Construction of coarse-grained (CG) models for large biomolecules used for multiscale simulations demands a rigorous definition of CG sites for them. Several coarse-graining methods such as the simulated annealing and steepest descent (SASD) based on the essential dynamics coarse-graining (ED-CG) or the stepwise local iterative optimization (SLIO) based on the fluctuation maximization coarse-graining (FM-CG), were developed to do it. However, the practical applications of these methods such as SASD based on ED-CG are subject to limitations because they are too expensive. In this work, we extend the applicability of ED-CG by combining it with the SLIO algorithm. A comprehensive comparison of optimized results and accuracy of various algorithms based on ED-CG show that SLIO is the fastest as well as the most accurate algorithm among them. ED-CG combined with SLIO could give converged results as the number of CG sites increases, which demonstrates that it is another efficient method for coarse-graining large biomolecules. The construction of CG sites for Ras protein by using MD fluctuations demonstrates that the CG sites derived from FM-CG can reflect the fluctuation properties of secondary structures in Ras accurately.

Development, testing, and applications of site-specific tsunami inundation models for real-time forecasting

NASA Astrophysics Data System (ADS)

Tang, L.; Titov, V. V.; Chamberlin, C. D.

2009-12-01

The study describes the development, testing and applications of site-specific tsunami inundation models (forecast models) for use in NOAA's tsunami forecast and warning system. The model development process includes sensitivity studies of tsunami wave characteristics in the nearshore and inundation, for a range of model grid setups, resolutions and parameters. To demonstrate the process, four forecast models in Hawaii, at Hilo, Kahului, Honolulu, and Nawiliwili are described. The models were validated with fourteen historical tsunamis and compared with numerical results from reference inundation models of higher resolution. The accuracy of the modeled maximum wave height is greater than 80% when the observation is greater than 0.5 m; when the observation is below 0.5 m the error is less than 0.3 m. The error of the modeled arrival time of the first peak is within 3% of the travel time. The developed forecast models were further applied to hazard assessment from simulated magnitude 7.5, 8.2, 8.7 and 9.3 tsunamis based on subduction zone earthquakes in the Pacific. The tsunami hazard assessment study indicates that use of a seismic magnitude alone for a tsunami source assessment is inadequate to achieve such accuracy for tsunami amplitude forecasts. The forecast models apply local bathymetric and topographic information, and utilize dynamic boundary conditions from the tsunami source function database, to provide site- and event-specific coastal predictions. Only by combining a Deep-ocean Assessment and Reporting of Tsunami-constrained tsunami magnitude with site-specific high-resolution models can the forecasts completely cover the evolution of earthquake-generated tsunami waves: generation, deep ocean propagation, and coastal inundation. Wavelet analysis of the tsunami waves suggests the coastal tsunami frequency responses at different sites are dominated by the local bathymetry, yet they can be partially related to the locations of the tsunami sources. The study also demonstrates the nonlinearity between offshore and nearshore maximum wave amplitudes.

A newly developed dispersal metric indicates the succession of benthic invertebrates in restored rivers.

PubMed

Li, Fengqing; Sundermann, Andrea; Stoll, Stefan; Haase, Peter

2016-11-01

Dispersal capacity plays a fundamental role in the riverine benthic invertebrate colonization of new habitats that emerges following flash floods or restoration. However, an appropriate measure of dispersal capacity for benthic invertebrates is still lacking. The dispersal of benthic invertebrates occurs mainly during the aquatic (larval) and aerial (adult) life stages, and the dispersal of each stage can be further subdivided into active and passive modes. Based on these four possible dispersal modes, we first developed a metric (which is very similar to the well-known and widely used saprobic index) to estimate the dispersal capacity for 802 benthic invertebrate taxa by incorporating a weight for each mode. Second, we tested this metric using benthic invertebrate community data from a) 23 large restored river sites with substantial improvements of river bottom habitats dating back 1 to 10years, b) 23 unrestored sites very close to the restored sites, and c) 298 adjacent surrounding sites (mean±standard deviation: 13.0±9.5 per site) within a distance of up to 5km for each restored site in the low mountain and lowland areas of Germany. We hypothesize that our metric will reflect the temporal succession process of benthic invertebrate communities colonizing the restored sites, whereas no temporal changes are expected in the unrestored and surrounding sites. By applying our metric to these three river treatment categories, we found that the average dispersal capacity of benthic invertebrate communities in the restored sites significantly decreased in the early years following restoration, whereas there were no changes in either the unrestored or the surrounding sites. After all taxa had been divided into quartiles representing weak to strong dispersers, this pattern became even more obvious; strong dispersers colonized the restored sites during the first year after restoration and then significantly decreased over time, whereas weak dispersers continued to increase. The successful application of our metric to river restoration might be promising in further applications of this metric, for example, in analyzing metacommunity structure or community's recovery from extreme events such as floods, droughts or catastrophic pollution episodes. Copyright © 2016 Elsevier B.V. All rights reserved.

Visual sensitivity of river recreation to power plants

Treesearch

David H. Blau; Michael C. Bowie

1979-01-01

The consultants were asked by the Power Plant Siting Staff of the Minnesota Environmental Quality Council to develop a methodology for evaluating the sensitivity of river-related recreational activities to visual intrusion by large coal-fired power plants. The methodology, which is applicable to any major stream in the state, was developed and tested on a case study...

The role of genetics in improving forest health

Treesearch

Mary F. Mahalovich

1995-01-01

An often ignored tool to improve forest health is the application of genetics-Tree improvement programs in the Inland West utilize genetic principles to develop-seed transfer guidelines to avoid the problems associated with off-site plantings and to improve characteristics in conifers related to forest health. PC-based expert systems have been developed to aid in seed...

7 CFR Exhibit J to Subpart A of... - Manufactured Home Sites, Rental Projects and Subdivisions: Development, Installation and Set-Up

Code of Federal Regulations, 2014 CFR

2014-01-01

..., Specifications, Contract Documents and Other Documentation Part D—Inspection of Development Work Part A..., installation, device, arrangement, or method of work is at least equivalent to that prescribed in this exhibit..., within allowable stress and settlement limitations, all applicable loads. Any foundation and anchorage...

7 CFR Exhibit J to Subpart A of... - Manufactured Home Sites, Rental Projects and Subdivisions: Development, Installation and Set-Up

Code of Federal Regulations, 2011 CFR

2011-01-01

..., Specifications, Contract Documents and Other Documentation Part D—Inspection of Development Work Part A..., installation, device, arrangement, or method of work is at least equivalent to that prescribed in this exhibit..., within allowable stress and settlement limitations, all applicable loads. Any foundation and anchorage...

7 CFR Exhibit J to Subpart A of... - Manufactured Home Sites, Rental Projects and Subdivisions: Development, Installation and Set-Up

Code of Federal Regulations, 2012 CFR

2012-01-01

..., Specifications, Contract Documents and Other Documentation Part D—Inspection of Development Work Part A..., installation, device, arrangement, or method of work is at least equivalent to that prescribed in this exhibit..., within allowable stress and settlement limitations, all applicable loads. Any foundation and anchorage...

77 FR 27714 - Foreign-Trade Zone 220-Sioux Falls, SD; Application for Reorganization and Expansion Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-35-2012] Foreign-Trade Zone 220--Sioux Falls... been submitted to the Foreign-Trade Zones (FTZ) Board (the Board) by the Sioux Falls Development... Field, 2801 Jaycee Lane, Sioux Falls; Site 2 (123 acres)--Sioux Falls Development Foundation Park III...

Conservation and restoration of forested wetlands: new techniques and perspectives

Treesearch

James Johnston; Steve Hartley; Antonio Martucci

2000-01-01

A partnership of state and federal agencies and private organizations is developing advanced spatial analysis techniques applied for conservation and restoration of forested wetlands. The project goal is to develop an application to assist decisionmakers in defining the eligibility of land sites for entry in the Wetland Reserve Program (WRP) of the U.S. Department of...

Solar heating and cooling system design and development

NASA Technical Reports Server (NTRS)

1979-01-01

The design and development of marketable solar heating and cooling systems for single family and commercial applications is described. The delivery, installation, and monitoring of the prototype systems are discussed. Seven operational test sites are discussed in terms of system performance. Problems encountered with equipment and installation were usually due to lack of skills required for solar system installation.

Health Literacy Training for Public Health Nurses in Fukushima: A Multi-site Program Evaluation.

PubMed

Goto, Aya; Lai, Alden Yuanhong; Rudd, Rima E

2015-09-01

Public health nurses (PHNs) are community residents' access points to health information and services in Japan. After the Fukushima nuclear accident, they were challenged to communicate radiation-related health information to best meet community needs. We previously developed and evaluated the outcome of a single-site health literacy training program to augment PHNs' ability to improve community residents' access to written health information. This paper presents an evaluation of an identical training program using data combined from multiple sites, and further included proximal and distal evaluations to document the impact of health literacy training in a post-disaster setting. A total of 64 participants, primarily experienced PHNs, attended one of three multi-session health literacy workshops conducted in multiple sites across Fukushima. Quantitative and qualitative data on PHNs' training satisfaction, self-evaluation of achievements regarding training goals, and application of learned skills were collected and analyzed. Each workshop consisted of two 2-hour sessions introducing health literacy and assessment tools and developing skills to improve written materials, followed by a one-month follow-up assessment on PHNs' application of the gained skills in the field. Post-training evaluations on the appropriateness and usefulness of the workshop were highly positive. At the end of the one-month follow-up, 45% of participants had gained confidence in assessing and revising written materials and had applied the skills they had gained to develop and communicate health information in various settings and modes. This increase in confidence was associated with further application of the learned skills at the municipal level. However, participants reported difficulties in explaining risks, and the need to learn more about plain language to be able to paraphrase professional terms. This paper highlighs the positive outcomes of health literacy training among PHNs. Practical strategies to reinforce their skills to use plain language and communicate the epidemiological concept of risk are also recommended.

Development and application of marine gamma-ray measurements: a review.

PubMed

Jones, D G

2001-01-01

The development of instruments to measure gamma radiation in the marine environment, particularly on the sea floor, and the range of uses to which they have been put is reviewed. Since the first steps in the late 1950s, systems have been developed in at least 10 countries with the main thrust occurring in the 1970s. Development has continued up to the present, primarily in Europe and the USA. Marine gamma-ray spectrometers have been used for a range of applications including the mapping of rocks and unconsolidated sediments, mineral exploration (mainly for heavy minerals and phosphorites), sediment transport studies and investigations in relation to discharged and dumped nuclear wastes and at nuclear weapon test sites.

Real-time analysis application for identifying bursty local areas related to emergency topics.

PubMed

Sakai, Tatsuhiro; Tamura, Keiichi

2015-01-01

Since social media started getting more attention from users on the Internet, social media has been one of the most important information source in the world. Especially, with the increasing popularity of social media, data posted on social media sites are rapidly becoming collective intelligence, which is a term used to refer to new media that is displacing traditional media. In this paper, we focus on geotagged tweets on the Twitter site. These geotagged tweets are referred to as georeferenced documents because they include not only a short text message, but also the documents' posting time and location. Many researchers have been tackling the development of new data mining techniques for georeferenced documents to identify and analyze emergency topics, such as natural disasters, weather, diseases, and other incidents. In particular, the utilization of geotagged tweets to identify and analyze natural disasters has received much attention from administrative agencies recently because some case studies have achieved compelling results. In this paper, we propose a novel real-time analysis application for identifying bursty local areas related to emergency topics. The aim of our new application is to provide new platforms that can identify and analyze the localities of emergency topics. The proposed application is composed of three core computational intelligence techniques: the Naive Bayes classifier technique, the spatiotemporal clustering technique, and the burst detection technique. Moreover, we have implemented two types of application interface: a Web application interface and an android application interface. To evaluate the proposed application, we have implemented a real-time weather observation system embedded the proposed application. we used actual crawling geotagged tweets posted on the Twitter site. The weather observation system successfully detected bursty local areas related to observed emergency weather topics.

10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Pre-Application Early Review of Site Suitability Issues Q... FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This... Reactor Safeguards of requests for early review of one or more site suitability issues relating to the...

10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Pre-Application Early Review of Site Suitability Issues Q... FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This... Reactor Safeguards of requests for early review of one or more site suitability issues relating to the...

10 CFR 2.621 - Acceptance and docketing of application for early review of site suitability issues in a combined...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Acceptance and docketing of application for early review... Procedures Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application... Issuance of Limited Work Authorizations Early Partial Decisions on Site Suitability-Combined License Under...

10 CFR 2.603 - Acceptance and docketing of application for early review of site suitability issues in a...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Acceptance and docketing of application for early review... Procedures Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application... Issuance of Limited Work Authorizations Early Partial Decisions on Site Suitability-Construction Permit § 2...

Application of Spatial Data Modeling and Geographical Information Systems (GIS) for Identification of Potential Siting Options for Various Electrical Generation Sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mays, Gary T; Belles, Randy; Blevins, Brandon R

2012-05-01

Oak Ridge National Laboratory (ORNL) initiated an internal National Electric Generation Siting Study, which is an ongoing multiphase study addressing several key questions related to our national electrical energy supply. This effort has led to the development of a tool, OR-SAGE (Oak Ridge Siting Analysis for power Generation Expansion), to support siting evaluations. The objective in developing OR-SAGE was to use industry-accepted approaches and/or develop appropriate criteria for screening sites and employ an array of Geographic Information Systems (GIS) data sources at ORNL to identify candidate areas for a power generation technology application. The initial phase of the study examinedmore » nuclear power generation. These early nuclear phase results were shared with staff from the Electric Power Research Institute (EPRI), which formed the genesis and support for an expansion of the work to several other power generation forms, including advanced coal with carbon capture and storage (CCS), solar, and compressed air energy storage (CAES). Wind generation was not included in this scope of work for EPRI. The OR-SAGE tool is essentially a dynamic visualization database. The results shown in this report represent a single static set of results using a specific set of input parameters. In this case, the GIS input parameters were optimized to support an economic study conducted by EPRI. A single set of individual results should not be construed as an ultimate energy solution, since US energy policy is very complex. However, the strength of the OR-SAGE tool is that numerous alternative scenarios can be quickly generated to provide additional insight into electrical generation or other GIS-based applications. The screening process divides the contiguous United States into 100 x 100 m (1-hectare) squares (cells), applying successive power generation-appropriate site selection and evaluation criteria (SSEC) to each cell. There are just under 700 million cells representing the contiguous United States. If a cell meets the requirements of each criterion, the cell is deemed a candidate area for siting a specific power generation form relative to a reference plant for that power type. Some SSEC parameters preclude siting a power plant because of an environmental, regulatory, or land-use constraint. Other SSEC assist in identifying less favorable areas, such as proximity to hazardous operations. All of the selected SSEC tend to recommend against sites. The focus of the ORNL electrical generation source siting study is on identifying candidate areas from which potential sites might be selected, stopping short of performing any detailed site evaluations or comparisons. This approach is designed to quickly screen for and characterize candidate areas. Critical assumptions supporting this work include the supply of cooling water to thermoelectric power generation; a methodology to provide an adequate siting footprint for typical power plant applications; a methodology to estimate thermoelectric plant capacity while accounting for available cooling water; and a methodology to account for future ({approx}2035) siting limitations as population increases and demands on freshwater sources change. OR-SAGE algorithms were built to account for these critical assumptions. Stream flow is the primary thermoelectric plant cooling source evaluated in this study. All cooling was assumed to be provided by a closed-cycle cooling (CCC) system requiring makeup water to account for evaporation and blowdown. Limited evaluations of shoreline cooling and the use of municipal processed water (gray) cooling were performed. Using a representative set of SSEC as input to the OR-SAGE tool and employing the accompanying critical assumptions, independent results for the various power generation sources studied were calculated.« less

Structure-based discovery and binding site analysis of histamine receptor ligands.

PubMed

Kiss, Róbert; Keserű, György M

2016-12-01

The application of structure-based drug discovery in histamine receptor projects was previously hampered by the lack of experimental structures. The publication of the first X-ray structure of the histamine H1 receptor has been followed by several successful virtual screens and binding site analysis studies of H1-antihistamines. This structure together with several other recently solved aminergic G-protein coupled receptors (GPCRs) enabled the development of more realistic homology models for H2, H3 and H4 receptors. Areas covered: In this paper, the authors review the development of histamine receptor models and their application in drug discovery. Expert opinion: In the authors' opinion, the application of atomistic histamine receptor models has played a significant role in understanding key ligand-receptor interactions as well as in the discovery of novel chemical starting points. The recently solved H1 receptor structure is a major milestone in structure-based drug discovery; however, our analysis also demonstrates that for building H3 and H4 receptor homology models, other GPCRs may be more suitable as templates. For these receptors, the authors envisage that the development of higher quality homology models will significantly contribute to the discovery and optimization of novel H3 and H4 ligands.

Waste Information Management System-2012 - 12114

DOE Office of Scientific and Technical Information (OSTI.GOV)

Upadhyay, H.; Quintero, W.; Shoffner, P.

2012-07-01

The Waste Information Management System (WIMS) -2012 was updated to support the Department of Energy (DOE) accelerated cleanup program. The schedule compression required close coordination and a comprehensive review and prioritization of the barriers that impeded treatment and disposition of the waste streams at each site. Many issues related to waste treatment and disposal were potential critical path issues under the accelerated schedule. In order to facilitate accelerated cleanup initiatives, waste managers at DOE field sites and at DOE Headquarters in Washington, D.C., needed timely waste forecast and transportation information regarding the volumes and types of radioactive waste that wouldmore » be generated by DOE sites over the next 40 years. Each local DOE site historically collected, organized, and displayed waste forecast information in separate and unique systems. In order for interested parties to understand and view the complete DOE complex-wide picture, the radioactive waste and shipment information of each DOE site needed to be entered into a common application. The WIMS application was therefore created to serve as a common application to improve stakeholder comprehension and improve DOE radioactive waste treatment and disposal planning and scheduling. WIMS allows identification of total forecasted waste volumes, material classes, disposition sites, choke points, technological or regulatory barriers to treatment and disposal, along with forecasted waste transportation information by rail, truck and inter-modal shipments. The Applied Research Center (ARC) at Florida International University (FIU) in Miami, Florida, developed and deployed the web-based forecast and transportation system and is responsible for updating the radioactive waste forecast and transportation data on a regular basis to ensure the long-term viability and value of this system. WIMS continues to successfully accomplish the goals and objectives set forth by DOE for this project. It has replaced the historic process of each DOE site gathering, organizing, and reporting their waste forecast information utilizing different databases and display technologies. In addition, WIMS meets DOE's objective to have the complex-wide waste forecast and transportation information available to all stakeholders and the public in one easy-to-navigate system. The enhancements to WIMS made since its initial deployment include the addition of new DOE sites and facilities, an updated waste and transportation information, and the ability to easily display and print customized waste forecast, the disposition maps, GIS maps and transportation information. The system also allows users to customize and generate reports over the web. These reports can be exported to various formats, such as Adobe{sup R} PDF, Microsoft Excel{sup R}, and Microsoft Word{sup R} and downloaded to the user's computer. Future enhancements will include database/application migration to the next level. A new data import interface will be developed to integrate 2012-13 forecast waste streams. In addition, the application is updated on a continuous basis based on DOE feedback. (authors)« less

AIR MONITOR SITING BY OBJECTIVE

EPA Science Inventory

A method is developed whereby measured pollutant concentrations can be used in conjunction with a mathematical air quality model to estimate the full spatial and temporal concentration distributions of the pollutants over a given region. The method is based on the application of ...

7 CFR 1948.84 - Application procedure for site development and acquisition grants.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Evidence that the land is stable if the land has been previously mined (include relevant data on soil and... qualified appraisers or engineers/architects; (9) A topographical map of the area; (10) Form FmHA or its...

7 CFR 1948.84 - Application procedure for site development and acquisition grants.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Evidence that the land is stable if the land has been previously mined (include relevant data on soil and... qualified appraisers or engineers/architects; (9) A topographical map of the area; (10) Form FmHA or its...

7 CFR 1948.84 - Application procedure for site development and acquisition grants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... project is a part of and consistent with the State Investment Strategy for Energy Impacted Areas; (3) Send... copy of the State Investment for Energy Areas; and (17) District, where appropriate, and State FmHA or...

PLUME-SCALER-EVALUATING LONG-TERM MONITORING WELL NETWORKS

EPA Science Inventory

EPA's Subsurface Protection and Remediation Division is developing a new computer application called PLUME-SCALER to evaluate long term monitoring well networks using typically available historical site water level data. PLUME-SCALER can be used to determine if there are enough ...

The Internet and education in surgery.

PubMed

Veldenz, H C; Dennis, J W

1998-09-01

The purpose of this review is to explain the developing role of the Internet and the World Wide Web (WWW) in promoting education in surgery. Internet sites relevant to surgery are appearing rapidly. Remote literature searches can query for surgery trials and results. Societies are using the WWW for transmission and review of publication materials. News groups interactively discuss current developments and trends. Surgeons are using personal and institutional sites to advertise services. Conventional slide shows migrate to the WWW for convenient downloading for surgeons and patients. Multimedia capabilities of the WWW expand the depth of information transmission, enabling education emanating from remote sites with narration and video depiction of procedures. These sophisticated tools can be demonstrated today with real online applications. One site facilitates surgical education using the WWW for program information, symposium coordination, links to regional subspecialty societies, residency cataloging, patient question and answer forums, and multimedia procedure descriptions. The principles of WWW communication used in this website can adapt to meet any educational need. The specialty of surgery is well suited to incorporation of online multimedia education over the Internet to follow new developments in our field.

Repeat 24-hour recalls and locally developed food composition databases: a feasible method to estimate dietary adequacy in a multi-site preconception maternal nutrition RCT.

PubMed

Lander, Rebecca L; Hambidge, K Michael; Krebs, Nancy F; Westcott, Jamie E; Garces, Ana; Figueroa, Lester; Tejeda, Gabriela; Lokangaka, Adrien; Diba, Tshilenge S; Somannavar, Manjunath S; Honnayya, Ranjitha; Ali, Sumera A; Khan, Umber S; McClure, Elizabeth M; Thorsten, Vanessa R; Stolka, Kristen B

2017-01-01

Background : Our aim was to utilize a feasible quantitative methodology to estimate the dietary adequacy of >900 first-trimester pregnant women in poor rural areas of the Democratic Republic of the Congo, Guatemala, India and Pakistan. This paper outlines the dietary methods used. Methods : Local nutritionists were trained at the sites by the lead study nutritionist and received ongoing mentoring throughout the study. Training topics focused on the standardized conduct of repeat multiple-pass 24-hr dietary recalls, including interview techniques, estimation of portion sizes, and construction of a unique site-specific food composition database (FCDB). Each FCDB was based on 13 food groups and included values for moisture, energy, 20 nutrients (i.e. macro- and micronutrients), and phytate (an anti-nutrient). Nutrient values for individual foods or beverages were taken from recently developed FAO-supported regional food composition tables or the USDA national nutrient database. Appropriate adjustments for differences in moisture and application of nutrient retention and yield factors after cooking were applied, as needed. Generic recipes for mixed dishes consumed by the study population were compiled at each site, followed by calculation of a median recipe per 100 g. Each recipe's nutrient values were included in the FCDB. Final site FCDB checks were planned according to FAO/INFOODS guidelines. Discussion : This dietary strategy provides the opportunity to assess estimated mean group usual energy and nutrient intakes and estimated prevalence of the population 'at risk' of inadequate intakes in first-trimester pregnant women living in four low- and middle-income countries. While challenges and limitations exist, this methodology demonstrates the practical application of a quantitative dietary strategy for a large international multi-site nutrition trial, providing within- and between-site comparisons. Moreover, it provides an excellent opportunity for local capacity building and each site FCDB can be easily modified for additional research activities conducted in other populations living in the same area.

The Human Transcript Database: A Catalogue of Full Length cDNA Inserts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bouckk John; Michael McLeod; Kim Worley

1999-09-10

The BCM Search Launcher provided improved access to web-based sequence analysis services during the granting period and beyond. The Search Launcher web site grouped analysis procedures by function and provided default parameters that provided reasonable search results for most applications. For instance, most queries were automatically masked for repeat sequences prior to sequence database searches to avoid spurious matches. In addition to the web-based access and arrangements that were made using the functions easier, the BCM Search Launcher provided unique value-added applications like the BEAUTY sequence database search tool that combined information about protein domains and sequence database search resultsmore » to give an enhanced, more complete picture of the reliability and relative value of the information reported. This enhanced search tool made evaluating search results more straight-forward and consistent. Some of the favorite features of the web site are the sequence utilities and the batch client functionality that allows processing of multiple samples from the command line interface. One measure of the success of the BCM Search Launcher is the number of sites that have adopted the models first developed on the site. The graphic display on the BLAST search from the NCBI web site is one such outgrowth, as is the display of protein domain search results within BLAST search results, and the design of the Biology Workbench application. The logs of usage and comments from users confirm the great utility of this resource.« less

Development and Applications of Portable Biosensors.

PubMed

Srinivasan, Balaji; Tung, Steve

2015-08-01

The significance of microfluidics-based and microelectromechanical systems-based biosensors has been widely acknowledged, and many reviews have explored their potential applications in clinical diagnostics, personalized medicine, global health, drug discovery, food safety, and forensics. Because health care costs are increasing, there is an increasing need to remotely monitor the health condition of patients by point-of-care-testing. The demand for biosensors for detection of biological warfare agents has increased, and research is focused on ways of producing small portable devices that would allow fast, accurate, and on-site detection. In the past decade, the demand for rapid and accurate on-site detection of plant disease diagnosis has increased due to emerging pathogens with resistance to pesticides, increased human mobility, and regulations limiting the application of toxic chemicals to prevent spread of diseases. The portability of biosensors for on-site diagnosis is limited due to various issues, including sample preparation techniques, fluid-handling techniques, the limited lifetime of biological reagents, device packaging, integrating electronics for data collection/analysis, and the requirement of external accessories and power. Many microfluidic, electronic, and biological design strategies, such as handling liquids in biosensors without pumps/valves, the application of droplet-based microfluidics, paper-based microfluidic devices, and wireless networking capabilities for data transmission, are being explored. © 2015 Society for Laboratory Automation and Screening.

Application of Near-Surface Remote Sensing and computer algorithms in evaluating impacts of agroecosystem management on Zea mays (corn) phenological development in the Platte River - High Plains Aquifer Long Term Agroecosystem Research Network field sites.

NASA Astrophysics Data System (ADS)

Okalebo, J. A.; Das Choudhury, S.; Awada, T.; Suyker, A.; LeBauer, D.; Newcomb, M.; Ward, R.

2017-12-01

The Long-term Agroecosystem Research (LTAR) network is a USDA-ARS effort that focuses on conducting research that addresses current and emerging issues in agriculture related to sustainability and profitability of agroecosystems in the face of climate change and population growth. There are 18 sites across the USA covering key agricultural production regions. In Nebraska, a partnership between the University of Nebraska - Lincoln and ARD/USDA resulted in the establishment of the Platte River - High Plains Aquifer LTAR site in 2014. The site conducts research to sustain multiple ecosystem services focusing specifically on Nebraska's main agronomic production agroecosystems that comprise of abundant corn, soybeans, managed grasslands and beef production. As part of the national LTAR network, PR-HPA participates and contributes near-surface remotely sensed imagery of corn, soybean and grassland canopy phenology to the PhenoCam Network through high-resolution digital cameras. This poster highlights the application, advantages and usefulness of near-surface remotely sensed imagery in agroecosystem studies and management. It demonstrates how both Infrared and Red-Green-Blue imagery may be applied to monitor phenological events as well as crop abiotic stresses. Computer-based algorithms and analytic techniques proved very instrumental in revealing crop phenological changes such as green-up and tasseling in corn. This poster also reports the suitability and applicability of corn-derived computer based algorithms for evaluating phenological development of sorghum since both crops have similarities in their phenology; with sorghum panicles being similar to corn tassels. This later assessment was carried out using a sorghum dataset obtained from the Transportation Energy Resources from Renewable Agriculture Phenotyping Reference Platform project, Maricopa Agricultural Center, Arizona.

Is There Segregation of Rare Earth Ions in Garnet Optical Ceramics?

NASA Astrophysics Data System (ADS)

Boulon, Georges; Epicier, T.; Zhao, W.; Guzik, M.; Pan, Y.; Jiang, B.

Research on advanced optical materials for a large variety of applications is always increasing. As an example, we can note high progress in solid-state laser sources like laser-diode (LD) - pumped solid-state lasers (DPSSL) including developments of new materials and high-power laser diode led to high-power and tuneable solid-state lasers. A wide variety of materials has been studied to develop more efficient and high power microchip lasers [1]. In end-pumping schemes, in particular, materials with a short absorption length for the LD pump beam are strongly anticipated for highly efficient operations because of the excellent match between the mode and pump beam profiles. High Nd3+ concentrations were so considered such as NdP5O14, LiNdP4O12 (LNP), and NdAl3(BO3)O4. However, crystal growths of these compositions are not so easy. Cubic crystals are much more researched. When looking at the literature for actual applications, we see immediately the importance of cubic garnet crystals for which dodecahedral (Y3+), octahedral (Al3+) and tetrahedral (Al3+) sites are considered as a reservoir for many activators like: Ce3+, Nd3+, Er3+, Tm3+, Ho3+, Yb3+ rare earth ions in dodecahedral symmetry sites and transition metal ions like Cr3+ in the octahedral symmetry sites or Cr4+ in the tetrahedral symmetry sites. Among garnet crystals, Y3Al5O12 (YAG) host is the most used, commercially produced by the Czochralski method. However, in the case of the most used Nd3+: YAG laser crystal, the Nd3+ concentration that affects the performance in laser applications, is strongly limited to 0.2-1.4 Nd3+ at. % as a result of the segregation distribution coefficient [1].

Development and Evaluation of Micro-Electrocorticography Arrays for Neural Interfacing Applications

NASA Astrophysics Data System (ADS)

Schendel, Amelia Ann

Neural interfaces have great promise for both electrophysiological research and therapeutic applications. Whether for the study of neural circuitry or for neural prosthetic or other therapeutic applications, micro-electrocorticography (micro-ECoG) arrays have proven extremely useful as neural interfacing devices. These devices strike a balance between invasiveness and signal resolution, an important step towards eventual human application. The objective of this research was to make design improvements to micro-ECoG devices to enhance both biocompatibility and device functionality. To best evaluate the effectiveness of these improvements, a cranial window imaging method for in vivo monitoring of the longitudinal tissue response post device implant was developed. Employment of this method provided valuable insight into the way tissue grows around micro-ECoG arrays after epidural implantation, spurring a study of the effects of substrate geometry on the meningeal tissue response. The results of the substrate footprint comparison suggest that a more open substrate geometry provides an easy path for the tissue to grow around to the top side of the device, whereas a solid device substrate encourages the tissue to thicken beneath the device, between the electrode sites and the brain. The formation of thick scar tissue between the recording electrode sites and the neural tissue is disadvantageous for long-term recorded signal quality, and thus future micro-ECoG device designs should incorporate open-architecture substrates for enhanced longitudinal in vivo function. In addition to investigating improvements for long-term device reliability, it was also desired to enhance the functionality of micro-ECoG devices for neural electrophysiology research applications. To achieve this goal, a completely transparent graphene-based device was fabricated for use with the cranial window imaging method and optogenetic techniques. The use of graphene as the conductive material provided the transparency necessary to image tissues directly below the micro-ECoG electrode sites, and to transmit light through the electrode sites to underlying neural tissue, for optical stimulation of neural cells. The flexibility and broad-spectrum transparency of graphene make it an ideal choice for thin-film, flexible electronic devices.

In silico fragment-based drug design.

PubMed

Konteatis, Zenon D

2010-11-01

In silico fragment-based drug design (FBDD) is a relatively new approach inspired by the success of the biophysical fragment-based drug discovery field. Here, we review the progress made by this approach in the last decade and showcase how it complements and expands the capabilities of biophysical FBDD and structure-based drug design to generate diverse, efficient drug candidates. Advancements in several areas of research that have enabled the development of in silico FBDD and some applications in drug discovery projects are reviewed. The reader is introduced to various computational methods that are used for in silico FBDD, the fragment library composition for this technique, special applications used to identify binding sites on the surface of proteins and how to assess the druggability of these sites. In addition, the reader will gain insight into the proper application of this approach from examples of successful programs. In silico FBDD captures a much larger chemical space than high-throughput screening and biophysical FBDD increasing the probability of developing more diverse, patentable and efficient molecules that can become oral drugs. The application of in silico FBDD holds great promise for historically challenging targets such as protein-protein interactions. Future advances in force fields, scoring functions and automated methods for determining synthetic accessibility will all aid in delivering more successes with in silico FBDD.

77 FR 75144 - Foreign-Trade Zone 277-Western Maricopa County, AZ; Application for Expansion; (New Magnet Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

... Maricopa County, AZ; Application for Expansion; (New Magnet Site) Under Alternative Site Framework An... additional new magnet sites in western Maricopa County, Arizona and request usage-driven designation for an..., Arizona. The current zone project includes the following magnet sites: Site 1 (230.25 acres)--within the...

Therapeutically equivalent pharmacokinetic profile across three application sites for AG200-15, a novel low-estrogen dose contraceptive patch.

PubMed

Stanczyk, Frank Z; Archer, David F; Rubin, Arkady; Foegh, Marie

2013-06-01

AG200-15 Agile Patch (AP) is a novel 7-day contraceptive patch providing ethinyl estradiol (EE) exposure comparable to low-dose combination oral contraceptives. This study determined whether application of the AP to three different anatomical sites (lower abdomen, buttock and upper torso) influences the pharmacokinetic profile of EE and levonorgestrel (LNG). In this open-label, three-period, crossover study, 24 subjects were randomized to one of six treatment sequences; each included application of patch to abdomen, buttock and upper torso, with the AP worn on one site for 7 days. After a 7-day washout, a new patch was applied to the next anatomical site. Multiple blood samples were collected up to 240 h after patch application. For plasma EE levels, median time to maximum drug concentration (Tmax, 24-48 h) and mean maximum concentration (Cmax, 47.9-61.5 pg/mL) were similar among application sites. Compared with lower abdomen, EE exposure was higher (16%-30%) at buttock and upper torso (15%-22%). For plasma LNG levels, median Tmax (72-120 h) and mean Cmax (1436-1589 pg/mL) were similar across application sites. Compared with lower abdomen, LNG exposure was higher at buttock (1%-7%) and upper torso (16%-17%). No serious adverse events (AEs) or AE-related discontinuations occurred. The most common treatment-emergent AEs were nausea, application site pruritus and headache, with frequencies comparable across anatomical sites. Absorption from the abdomen was slightly lower versus other sites; however, exposure to EE and LNG for all sites was therapeutically equivalent. The AP was well tolerated at all three anatomical sites. Copyright © 2013 Elsevier Inc. All rights reserved.

Novel Peptide Sequence (“IQ-tag”) with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging

PubMed Central

McCarthy, Jason R.; Weissleder, Ralph

2007-01-01

Background Probes that allow site-specific protein labeling have become critical tools for visualizing biological processes. Methods Here we used phage display to identify a novel peptide sequence with nanomolar affinity for near infrared (NIR) (benz)indolium fluorochromes. The developed peptide sequence (“IQ-tag”) allows detection of NIR dyes in a wide range of assays including ELISA, flow cytometry, high throughput screens, microscopy, and optical in vivo imaging. Significance The described method is expected to have broad utility in numerous applications, namely site-specific protein imaging, target identification, cell tracking, and drug development. PMID:17653285

10 CFR 2.604 - Notice of hearing on application for early review of site suitability issues in construction...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Notice of hearing on application for early review of site... AGENCY RULES OF PRACTICE AND PROCEDURE Additional Procedures Applicable to Early Partial Decisions on... Early Partial Decisions on Site Suitability-Construction Permit § 2.604 Notice of hearing on application...

10 CFR 2.604 - Notice of hearing on application for early review of site suitability issues in construction...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Notice of hearing on application for early review of site... AGENCY RULES OF PRACTICE AND PROCEDURE Additional Procedures Applicable to Early Partial Decisions on... Early Partial Decisions on Site Suitability-Construction Permit § 2.604 Notice of hearing on application...

New experimental sites for borehole geophysics, hydrodynamics and long-term monitoringITORING

NASA Astrophysics Data System (ADS)

Pezard, P.; Aliance/Saltrans Team

2003-04-01

In order to provide platforms for the development of new downhole geophysical and hydrodynamic sensors, 4 sites are being developped with a series of nearby 100 m deep boreholes located with a few meters to 100 meters, at the most. The objective is to set-up a cluster of extremely well characterized in-situ laboratories at scales where experiments cannot be conducted in traditionnal labs. At least one borehole is continuously cored at each of the sites, and the core is fully characterized in petrological, petrophysical and geochemical terms. An emphasis is placed on fundamental and environmental applications such as hydrogeology, waste storage or the study of seismogenic faults, whether for characterization purposes or the development of long-term monitoring sensors and methods. These sites are developped with the support of CNRS, the University of Montpellier and the ALIANCE program financed by the European Commission. The 4 sites span different lithologies with granite at Ploemeur (Brittany, France), Miocene carbonates from a reefal platform in south Mallorca (Baleares, Spain), Valanginian marly limestone at Lavalette, near Montpellier (Languedoc, France), and unconsolidated sands in a coastal setting also near Montpellier. In the context of ALIANCE, the goal is to improve the investigation, characterisation and monitoring of coastal aquifers for vulnerability assessment. For this, a set of geophysical approaches for the quantitative evaluation of brine intrusion will be developped. This includes the design of 5 new geophysical and hydrodynamical logging/testing sensors. Two end-member sites in terms of hydrogeological behavior will be set up for long-term experimentation, the testing of the new tools, and the validation of site-specific experimental and modelling protocols from µm- to 100 m-scale. Active in-situ testing from short and longer-term injections with variable salinity fluids will simulate overdrafting or saline water intrusion.

Construction site Voice Operated Information System (VOIS) test

NASA Astrophysics Data System (ADS)

Lawrence, Debbie J.; Hettchen, William

1991-01-01

The Voice Activated Information System (VAIS), developed by USACERL, allows inspectors to verbally log on-site inspection reports on a hand held tape recorder. The tape is later processed by the VAIS, which enters the information into the system's database and produces a written report. The Voice Operated Information System (VOIS), developed by USACERL and Automated Sciences Group, through a ESACERL cooperative research and development agreement (CRDA), is an improved voice recognition system based on the concepts and function of the VAIS. To determine the applicability of the VOIS to Corps of Engineers construction projects, Technology Transfer Test Bad (T3B) funds were provided to the Corps of Engineers National Security Agency (NSA) Area Office (Fort Meade) to procure and implement the VOIS, and to train personnel in its use. This report summarizes the NSA application of the VOIS to quality assurance inspection of radio frequency shielding and to progress payment logs, and concludes that the VOIS is an easily implemented system that can offer improvements when applied to repetitive inspection procedures. Use of VOIS can save time during inspection, improve documentation storage, and provide flexible retrieval of stored information.

Brazilian Consensus Recommendation on the Use of Polymethylmethacrylate Filler in Facial and Corporal Aesthetics.

PubMed

Blanco Souza, Túlio Armanini; Colomé, Letícia Marques; Bender, Eduardo André; Lemperle, Gottfriede

2018-06-05

Considering that aesthetic benefits can be obtained with the use of permanent filling materials, this work focuses on the development of a consensus regarding the facial and corporal use of polymethylmethacrylate (PMMA) filler in Brazil. A questionnaire regarding PMMA treatment, which included items on the main indication, application site, volume of product applied, criteria for selection of the material, complications, contraindications, and individual professional experience, was distributed to the Expert Group members. In addition, the responses were summarized, constituting the starting point for the debate regarding the use of PMMA-based fillers on The First Brazilian PMMA Symposium to create a guideline to be followed in PMMA facial and corporal treatments. This survey involved 87,371 cases. PMMA treatment is recommended for restorative and aesthetic purposes in facial and corporal cases, particularly for facial balance. PMMA 30% filler is recommended in specific facial sites (nose, mentum, mandible angle, zygomatic arc, and malar). PMMA filler is contraindicated in other sites (lips) regardless of concentration. With regard to facial treatment, the juxtaperiostal is the application plane most recommended. For PMMA corporal application, intramuscular is the application plane most indicated, while intradermal and justadermal planes are contraindicated. The submuscular plane application is relative to PMMA filler concentration. The experts also inquired regarding the amount of PMMA recommended in each corporal site (50 mL in the calf, 100-150 mL in the gluteal region). These recommendations provide a guideline for physicians, supporting them to perform safe and efficacious treatment with PMMA fillers. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors www.springer.com/00266 .

An ArcGIS decision support tool for artificial reefs site selection (ArcGIS ARSS)

NASA Astrophysics Data System (ADS)

Stylianou, Stavros; Zodiatis, George

2017-04-01

Although the use and benefits of artificial reefs, both socio-economic and environmental, have been recognized with research and national development programmes worldwide their development is rarely subjected to a rigorous site selection process and the majority of the projects use the traditional (non-GIS) approach, based on trial and error mode. Recent studies have shown that the use of Geographic Information Systems, unlike to traditional methods, for the identification of suitable areas for artificial reefs siting seems to offer a number of distinct advantages minimizing possible errors, time and cost. A decision support tool (DSS) has been developed based on the existing knowledge, the multi-criteria decision analysis techniques and the GIS approach used in previous studies in order to help the stakeholders to identify the optimal locations for artificial reefs deployment on the basis of the physical, biological, oceanographic and socio-economic features of the sites. The tool provides to the users the ability to produce a final report with the results and suitability maps. The ArcGIS ARSS support tool runs within the existing ArcMap 10.2.x environment and for the development the VB .NET high level programming language has been used along with ArcObjects 10.2.x. Two local-scale case studies were conducted in order to test the application of the tool focusing on artificial reef siting. The results obtained from the case studies have shown that the tool can be successfully integrated within the site selection process in order to select objectively the optimal site for artificial reefs deployment.

Conservation planning for offsetting the impacts of development: a case study of biodiversity and renewable energy in the Mojave Desert

USGS Publications Warehouse

Kreitler, Jason R.; Schloss, Carrie A.; Soong, Oliver; Lee Hannah,; Davis, Frank W.

2015-01-01

Balancing society’s competing needs of development and conservation requires careful consideration of tradeoffs. Renewable energy development and biodiversity conservation are often considered beneficial environmental goals. The direct footprint and disturbance of renewable energy, however, can displace species’ habitat and negatively impact populations and natural communities if sited without ecological consideration. Offsets have emerged as a potentially useful tool to mitigate residual impacts after trying to avoid, minimize, or restore affected sites. Yet the problem of efficiently designing a set of offset sites becomes increasingly complex where many species or many sites are involved. Spatial conservation prioritization tools are designed to handle this problem, but have seen little application to offset siting and analysis. To address this need we designed an offset siting support tool for the Desert Renewable Energy Conservation Plan (DRECP) of California, and present a case study of hypothetical impacts from solar development in the Western Mojave subsection. We compare two offset scenarios designed to mitigate a hypothetical 15,331 ha derived from proposed utility-scale solar energy development (USSED) projects. The first scenario prioritizes offsets based precisely on impacted features, while the second scenario offsets impacts to maximize biodiversity conservation gains in the region. The two methods only agree on 28% of their prioritized sites and differ in meeting species-specific offset goals. Differences between the two scenarios highlight the importance of clearly specifying choices and priorities for offset siting and mitigation in general. Similarly, the effects of background climate and land use change may lessen the durability or effectiveness of offsets if not considered. Our offset siting support tool was designed specifically for the DRECP area, but with minor code modification could work well in other offset analyses, and could provide continuing support for a potentially innovative mitigation solution to environmental impacts.

Conservation Planning for Offsetting the Impacts of Development: A Case Study of Biodiversity and Renewable Energy in the Mojave Desert.

PubMed

Kreitler, Jason; Schloss, Carrie A; Soong, Oliver; Hannah, Lee; Davis, Frank W

2015-01-01

Balancing society's competing needs of development and conservation requires careful consideration of tradeoffs. Renewable energy development and biodiversity conservation are often considered beneficial environmental goals. The direct footprint and disturbance of renewable energy, however, can displace species' habitat and negatively impact populations and natural communities if sited without ecological consideration. Offsets have emerged as a potentially useful tool to mitigate residual impacts after trying to avoid, minimize, or restore affected sites. Yet the problem of efficiently designing a set of offset sites becomes increasingly complex where many species or many sites are involved. Spatial conservation prioritization tools are designed to handle this problem, but have seen little application to offset siting and analysis. To address this need we designed an offset siting support tool for the Desert Renewable Energy Conservation Plan (DRECP) of California, and present a case study of hypothetical impacts from solar development in the Western Mojave subsection. We compare two offset scenarios designed to mitigate a hypothetical 15,331 ha derived from proposed utility-scale solar energy development (USSED) projects. The first scenario prioritizes offsets based precisely on impacted features, while the second scenario offsets impacts to maximize biodiversity conservation gains in the region. The two methods only agree on 28% of their prioritized sites and differ in meeting species-specific offset goals. Differences between the two scenarios highlight the importance of clearly specifying choices and priorities for offset siting and mitigation in general. Similarly, the effects of background climate and land use change may lessen the durability or effectiveness of offsets if not considered. Our offset siting support tool was designed specifically for the DRECP area, but with minor code modification could work well in other offset analyses, and could provide continuing support for a potentially innovative mitigation solution to environmental impacts.

Conservation Planning for Offsetting the Impacts of Development: A Case Study of Biodiversity and Renewable Energy in the Mojave Desert

PubMed Central

Kreitler, Jason; Schloss, Carrie A.; Soong, Oliver; Hannah, Lee; Davis, Frank W.

2015-01-01

Balancing society’s competing needs of development and conservation requires careful consideration of tradeoffs. Renewable energy development and biodiversity conservation are often considered beneficial environmental goals. The direct footprint and disturbance of renewable energy, however, can displace species’ habitat and negatively impact populations and natural communities if sited without ecological consideration. Offsets have emerged as a potentially useful tool to mitigate residual impacts after trying to avoid, minimize, or restore affected sites. Yet the problem of efficiently designing a set of offset sites becomes increasingly complex where many species or many sites are involved. Spatial conservation prioritization tools are designed to handle this problem, but have seen little application to offset siting and analysis. To address this need we designed an offset siting support tool for the Desert Renewable Energy Conservation Plan (DRECP) of California, and present a case study of hypothetical impacts from solar development in the Western Mojave subsection. We compare two offset scenarios designed to mitigate a hypothetical 15,331 ha derived from proposed utility-scale solar energy development (USSED) projects. The first scenario prioritizes offsets based precisely on impacted features, while the second scenario offsets impacts to maximize biodiversity conservation gains in the region. The two methods only agree on 28% of their prioritized sites and differ in meeting species-specific offset goals. Differences between the two scenarios highlight the importance of clearly specifying choices and priorities for offset siting and mitigation in general. Similarly, the effects of background climate and land use change may lessen the durability or effectiveness of offsets if not considered. Our offset siting support tool was designed specifically for the DRECP area, but with minor code modification could work well in other offset analyses, and could provide continuing support for a potentially innovative mitigation solution to environmental impacts. PMID:26529595

Watershed Regressions for Pesticides (WARP) models for predicting stream concentrations of multiple pesticides

USGS Publications Warehouse

Stone, Wesley W.; Crawford, Charles G.; Gilliom, Robert J.

2013-01-01

Watershed Regressions for Pesticides for multiple pesticides (WARP-MP) are statistical models developed to predict concentration statistics for a wide range of pesticides in unmonitored streams. The WARP-MP models use the national atrazine WARP models in conjunction with an adjustment factor for each additional pesticide. The WARP-MP models perform best for pesticides with application timing and methods similar to those used with atrazine. For other pesticides, WARP-MP models tend to overpredict concentration statistics for the model development sites. For WARP and WARP-MP, the less-than-ideal sampling frequency for the model development sites leads to underestimation of the shorter-duration concentration; hence, the WARP models tend to underpredict 4- and 21-d maximum moving-average concentrations, with median errors ranging from 9 to 38% As a result of this sampling bias, pesticides that performed well with the model development sites are expected to have predictions that are biased low for these shorter-duration concentration statistics. The overprediction by WARP-MP apparent for some of the pesticides is variably offset by underestimation of the model development concentration statistics. Of the 112 pesticides used in the WARP-MP application to stream segments nationwide, 25 were predicted to have concentration statistics with a 50% or greater probability of exceeding one or more aquatic life benchmarks in one or more stream segments. Geographically, many of the modeled streams in the Corn Belt Region were predicted to have one or more pesticides that exceeded an aquatic life benchmark during 2009, indicating the potential vulnerability of streams in this region.

33 CFR 401.2 - Interpretation.

Code of Federal Regulations, 2014 CFR

2014-07-01

...: (a) Corporation means the Saint Lawrence Seaway Development Corporation; (b) E-business means web applications on the St. Lawrence Seaway Management Corporation Web site which provides direct electronic...) Seaway means the deep waterway between the Port of Montreal and Lake Erie and includes all locks, canals...

State-and-transition models for heterogeneous landscapes: A strategy for development and application

USDA-ARS?s Scientific Manuscript database

Interpretation of assessment and monitoring data requires information about reference conditions and ecological resilience. Reference conditions used as benchmarks can be specified via potential-based land classifications (e.g., ecological sites) that describe the plant communities potentially obser...

Where Will LEAD Lead?

ERIC Educational Resources Information Center

Wildman, Louis

After setting forth eight assumptions concerning the education of educational administrators, findings about the Leadership in Educational Administration Development (LEAD) program are discussed. The analysis is based on the first-year applications, telephone conversations with staff at a majority of the project sites, and additional material…

Multimedia Sampling During The Application Of Biosolids On A Land Test Site

EPA Science Inventory

This report documents the approach, methodologies, results, and interpretation of a collaborative research study conducted by the National Risk Management Research Center (NRMRL) of the U.S. Environmental Protection Agency's (U.S. EPA's) Office of Research and Development (ORD); ...

caCORE: a common infrastructure for cancer informatics.

PubMed

Covitz, Peter A; Hartel, Frank; Schaefer, Carl; De Coronado, Sherri; Fragoso, Gilberto; Sahni, Himanso; Gustafson, Scott; Buetow, Kenneth H

2003-12-12

Sites with substantive bioinformatics operations are challenged to build data processing and delivery infrastructure that provides reliable access and enables data integration. Locally generated data must be processed and stored such that relationships to external data sources can be presented. Consistency and comparability across data sets requires annotation with controlled vocabularies and, further, metadata standards for data representation. Programmatic access to the processed data should be supported to ensure the maximum possible value is extracted. Confronted with these challenges at the National Cancer Institute Center for Bioinformatics, we decided to develop a robust infrastructure for data management and integration that supports advanced biomedical applications. We have developed an interconnected set of software and services called caCORE. Enterprise Vocabulary Services (EVS) provide controlled vocabulary, dictionary and thesaurus services. The Cancer Data Standards Repository (caDSR) provides a metadata registry for common data elements. Cancer Bioinformatics Infrastructure Objects (caBIO) implements an object-oriented model of the biomedical domain and provides Java, Simple Object Access Protocol and HTTP-XML application programming interfaces. caCORE has been used to develop scientific applications that bring together data from distinct genomic and clinical science sources. caCORE downloads and web interfaces can be accessed from links on the caCORE web site (http://ncicb.nci.nih.gov/core). caBIO software is distributed under an open source license that permits unrestricted academic and commercial use. Vocabulary and metadata content in the EVS and caDSR, respectively, is similarly unrestricted, and is available through web applications and FTP downloads. http://ncicb.nci.nih.gov/core/publications contains links to the caBIO 1.0 class diagram and the caCORE 1.0 Technical Guide, which provide detailed information on the present caCORE architecture, data sources and APIs. Updated information appears on a regular basis on the caCORE web site (http://ncicb.nci.nih.gov/core).

Mixed Reality in Visceral Surgery: Development of a Suitable Workflow and Evaluation of Intraoperative Use-cases.

PubMed

Sauer, Igor M; Queisner, Moritz; Tang, Peter; Moosburner, Simon; Hoepfner, Ole; Horner, Rosa; Lohmann, Rudiger; Pratschke, Johann

2017-11-01

The paper evaluates the application of a mixed reality (MR) headmounted display (HMD) for the visualization of anatomical structures in complex visceral-surgical interventions. A workflow was developed and technical feasibility was evaluated. Medical images are still not seamlessly integrated into surgical interventions and, thus, remain separated from the surgical procedure.Surgeons need to cognitively relate 2-dimensional sectional images to the 3-dimensional (3D) during the actual intervention. MR applications simulate 3D images and reduce the offset between working space and visualization allowing for improved spatial-visual approximation of patient and image. The surgeon's field of vision was superimposed with a 3D-model of the patient's relevant liver structures displayed on a MR-HMD. This set-up was evaluated during open hepatic surgery. A suitable workflow for segmenting image masks and texture mapping of tumors, hepatic artery, portal vein, and the hepatic veins was developed. The 3D model was positioned above the surgical site. Anatomical reassurance was possible simply by looking up. Positioning in the room was stable without drift and minimal jittering. Users reported satisfactory comfort wearing the device without significant impairment of movement. MR technology has a high potential to improve the surgeon's action and perception in open visceral surgery by displaying 3D anatomical models close to the surgical site. Superimposing anatomical structures directly onto the organs within the surgical site remains challenging, as the abdominal organs undergo major deformations due to manipulation, respiratory motion, and the interaction with the surgical instruments during the intervention. A further application scenario would be intraoperative ultrasound examination displaying the image directly next to the transducer. Displays and sensor-technologies as well as biomechanical modeling and object-recognition algorithms will facilitate the application of MR-HMD in surgery in the near future.

Chemical application strategies to protect water quality.

PubMed

Rice, Pamela J; Horgan, Brian P; Barber, Brian L; Koskinen, William C

2018-07-30

Management of turfgrass on golf courses and athletic fields often involves application of plant protection products to maintain or enhance turfgrass health and performance. However, the transport of fertilizer and pesticides with runoff to adjacent surface waters can enhance algal blooms, promote eutrophication and may have negative impacts on sensitive aquatic organisms and ecosystems. Thus, we evaluated the effectiveness of chemical application setbacks to reduce the off-site transport of chemicals with storm runoff. Experiments with water soluble tracer compounds confirmed an increase in application setback distance resulted in a significant increase in the volume of runoff measured before first off-site chemical detection, as well as a significant reduction in the total percentage of applied chemical transported with the storm runoff. For example, implementation of a 6.1 m application setback reduced the total percentage of an applied water soluble tracer by 43%, from 18.5% of applied to 10.5% of applied. Evaluation of chemographs revealed the efficacy of application setbacks could be observed with storms resulting in lesser (e.g. 100 L) and greater (e.g. > 300 L) quantities of runoff. Application setbacks offer turfgrass managers a mitigation approach that requires no additional resources or time inputs and may serve as an alternative practice when buffers are less appropriate for land management objectives or site conditions. Characterizing potential contamination of surface waters and developing strategies to safeguard water quality will help protect the environment and improve water resource security. This information is useful to grounds superintendents for designing chemical application strategies to maximize environmental stewardship. The data will also be useful to scientists and regulators working with chemical transport and risk models. Copyright © 2018. Published by Elsevier Inc.

Minimizing impacts of land use change on ecosystem services using multi-criteria heuristic analysis.

PubMed

Keller, Arturo A; Fournier, Eric; Fox, Jessica

2015-06-01

Development of natural landscapes to support human activities impacts the capacity of the landscape to provide ecosystem services. Typically, several ecosystem services are impacted at a single development site and various footprint scenarios are possible, thus a multi-criteria analysis is needed. Restoration potential should also be considered for the area surrounding the permanent impact site. The primary objective of this research was to develop a heuristic approach to analyze multiple criteria (e.g. impacts to various ecosystem services) in a spatial configuration with many potential development sites. The approach was to: (1) quantify the magnitude of terrestrial ecosystem service (biodiversity, carbon sequestration, nutrient and sediment retention, and pollination) impacts associated with a suite of land use change scenarios using the InVEST model; (2) normalize results across categories of ecosystem services to allow cross-service comparison; (3) apply the multi-criteria heuristic algorithm to select sites with the least impact to ecosystem services, including a spatial criterion (separation between sites). As a case study, the multi-criteria impact minimization algorithm was applied to InVEST output to select 25 potential development sites out of 204 possible locations (selected by other criteria) within a 24,000 ha property. This study advanced a generally applicable spatial multi-criteria approach for 1) considering many land use footprint scenarios, 2) balancing impact decisions across a suite of ecosystem services, and 3) determining the restoration potential of ecosystem services after impacts. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

A needs analysis method for land-use planning of illegal dumping sites: a case study in Aomori-Iwate, Japan.

PubMed

Ishii, Kazuei; Furuichi, Toru; Nagao, Yukari

2013-02-01

Land use at contaminated sites, following remediation, is often needed for regional redevelopment. However, there exist few methods of developing economically and socially feasible land-use plans based on regional needs because of the wide variety of land-use requirements. This study proposes a new needs analysis method for the conceptual land-use planning of contaminated sites and illustrates this method with a case study of an illegal dumping site for hazardous waste. In this method, planning factors consisting of the land-use attributes and related facilities are extracted from the potential needs of the residents through a preliminary questionnaire. Using the extracted attributes of land use and the related facilities, land-use cases are designed for selection-based conjoint analysis. A second questionnaire for respondents to the first one who indicated an interest in participating in the second questionnaire is conducted for the conjoint analysis to determine the utility function and marginal cost of each attribute in order to prioritize the planning factors to develop a quantitative and economically and socially feasible land-use plan. Based on the results, site-specific land-use alternatives are developed and evaluated by the utility function obtained from the conjoint analysis. In this case study of an illegal dumping site for hazardous waste, the uses preferred as part of a conceptual land-use plan following remediation of the site were (1) agricultural land and a biogas plant designed to recover energy from biomass or (2) a park with a welfare facility and an athletic field. Our needs analysis method with conjoint analysis is applicable to the development of conceptual land-use planning for similar sites following remediation, particularly when added value is considered. Copyright © 2012 Elsevier Ltd. All rights reserved.

Evaluation of physical activity web sites for use of behavior change theories.

PubMed

Doshi, Amol; Patrick, Kevin; Sallis, James F; Calfas, Karen

2003-01-01

Physical activity (PA) Web sites were assessed for their use of behavior change theories, including constructs of the health belief model, Transtheoretical Model, social cognitive theory, and the theory of reasoned action and planned behavior. An evaluation template for assessing PA Web sites was developed, and content validity and interrater reliability were demonstrated. Two independent raters evaluated 24 PA Web sites. Web sites varied widely in application of theory-based constructs, ranging from 5 to 48 on a 100-point scale. The most common intervention strategies were general information, social support, and realistic goal areas. Coverage of theory-based strategies was low, varying from 26% for social cognitive theory to 39% for health belief model. Overall, PA Web sites provided little assessment, feedback, or individually tailored assistance for users. They were unable to substantially tailor the on-line experience for users at different stages of change or different demographic characteristics.

Computational prediction of muon stopping sites using ab initio random structure searching (AIRSS)

NASA Astrophysics Data System (ADS)

Liborio, Leandro; Sturniolo, Simone; Jochym, Dominik

2018-04-01

The stopping site of the muon in a muon-spin relaxation experiment is in general unknown. There are some techniques that can be used to guess the muon stopping site, but they often rely on approximations and are not generally applicable to all cases. In this work, we propose a purely theoretical method to predict muon stopping sites in crystalline materials from first principles. The method is based on a combination of ab initio calculations, random structure searching, and machine learning, and it has successfully predicted the MuT and MuBC stopping sites of muonium in Si, diamond, and Ge, as well as the muonium stopping site in LiF, without any recourse to experimental results. The method makes use of Soprano, a Python library developed to aid ab initio computational crystallography, that was publicly released and contains all the software tools necessary to reproduce our analysis.

Assessing and Testing Hydrokinetic Turbine Performance and Effects on Open Channel Hydrodynamics: An Irrigation Canal Case Study.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gunawan, Budi; Neary, Vincent Sinclair; Mortensen, Josh

Hydrokinetic energy from flowing water in open channels has the potential to support local electricity needs with lower regulatory or capital investment than impounding water with more conventional means. MOU agencies involved in federal hydropower development have identified the need to better understand the opportunities for hydrokinetic (HK) energy development within existing canal systems that may already have integrated hydropower plants. This document provides an overview of the main considerations, tools, and assessment methods, for implementing field tests in an open-channel water system to characterize current energy converter (CEC) device performance and hydrodynamic effects. It describes open channel processes relevantmore » to their HK site and perform pertinent analyses to guide siting and CEC layout design, with the goal of streamlining the evaluation process and reducing the risk of interfering with existing uses of the site. This document outlines key site parameters of interest and effective tools and methods for measurement and analysis with examples drawn from the Roza Main Canal, in Yakima, WA to illustrate a site application.« less

Site occupancy models with heterogeneous detection probabilities

USGS Publications Warehouse

Royle, J. Andrew

2006-01-01

Models for estimating the probability of occurrence of a species in the presence of imperfect detection are important in many ecological disciplines. In these ?site occupancy? models, the possibility of heterogeneity in detection probabilities among sites must be considered because variation in abundance (and other factors) among sampled sites induces variation in detection probability (p). In this article, I develop occurrence probability models that allow for heterogeneous detection probabilities by considering several common classes of mixture distributions for p. For any mixing distribution, the likelihood has the general form of a zero-inflated binomial mixture for which inference based upon integrated likelihood is straightforward. A recent paper by Link (2003, Biometrics 59, 1123?1130) demonstrates that in closed population models used for estimating population size, different classes of mixture distributions are indistinguishable from data, yet can produce very different inferences about population size. I demonstrate that this problem can also arise in models for estimating site occupancy in the presence of heterogeneous detection probabilities. The implications of this are discussed in the context of an application to avian survey data and the development of animal monitoring programs.

Nanolithographic control of the spatial organization of cellular adhesion receptors at the single-molecule level

PubMed Central

Schvartzman, Mark; Palma, Matteo; Sable, Julia; Abramson, Justin; Hu, Xian; Sheetz, Michael P.; Wind, Shalom J.

2011-01-01

The ability to control the placement of individual molecules promises to enable a wide range of applications and is a key challenge in nanoscience and nanotechnology. Many biological interactions, in particular, are sensitive to the precise geometric arrangement of proteins. We have developed a technique which combines molecular-scale nanolithography with site-selective biochemistry to create biomimetic arrays of individual protein binding sites. The binding sites can be arranged in heterogeneous patterns of virtually any possible geometry with a nearly unlimited number of degrees of freedom. We have used these arrays to explore how the geometric organization of the extracellular matrix (ECM) binding ligand RGD (Arg-Gly-Asp) affects cell adhesion and spreading. Systematic variation of spacing, density and cluster size of individual integrin binding sites was used to elicit different cell behavior. Cell spreading assays on arrays of different geometric arrangements revealed a dramatic increase in spreading efficiency when at least 4 liganded sites were spaced within 60 nm or less, with no dependence on global density. This points to the existence of a minimal matrix adhesion unit for fibronectin defined in space and stoichiometry. Developing an understanding of the ECM geometries that activate specific cellular functional complexes is a critical step toward controlling cell behavior. Potential practical applications range from new therapeutic treatments to the rational design of tissue scaffolds that can optimize healing without scarring. More broadly, spatial control at the single-molecule level can elucidate factors controlling individual molecular interactions and can enable synthesis of new systems based on molecular-scale architectures. PMID:21319842

Development of nanowire arrays for neural probe

NASA Astrophysics Data System (ADS)

Abraham, Jose K.; Xie, Jining; Varadan, Vijay K.

2005-05-01

It is already established that functional electrical stimulation is an effective way to restore many functions of the brain in disabled individuals. The electrical stimulation can be done by using an array of electrodes. Neural probes stimulate or sense the biopotentials mainly through the exposed metal sites. These sites should be smaller relative to the spatial potential distribution so that any potential averaging in the sensing area can be avoided. At the same time, the decrease in size of these sensing sites is limited due to the increase in impedance levels and the thermal noise while decreasing its size. It is known that current density in a planar electrode is not uniform and a higher current density can be observer around the perimeter of the electrodes. Electrical measurements conducted on many nanotubes and nanowires have already proved that it could be possible to use for current density applications and the drawbacks of the present design in neural probes can be overcome by incorporating many nanotechnology solutions. In this paper we present the design and development of nanowire arrays for the neural probe for the multisite contact which has the ability to collect and analyze isolated single unit activity. An array of vertically grown nanowires is used as contact site and many of such arrays can be used for stimulating as well as recording sites. The nanolevel interaction and wireless communication solution can extend to applications involving the treatment of many neurological disorders including Parkinson"s disease, Alzheimer"s disease, spinal injuries and the treatment of blindness and paralyzed patients with minimal or no invasive surgical procedures.

Metamodeling-based approach for risk assessment and cost estimation: Application to geological carbon sequestration planning

NASA Astrophysics Data System (ADS)

Sun, Alexander Y.; Jeong, Hoonyoung; González-Nicolás, Ana; Templeton, Thomas C.

2018-04-01

Carbon capture and storage (CCS) is being evaluated globally as a geoengineering measure for significantly reducing greenhouse emission. However, long-term liability associated with potential leakage from these geologic repositories is perceived as a main barrier of entry to site operators. Risk quantification and impact assessment help CCS operators to screen candidate sites for suitability of CO2 storage. Leakage risks are highly site dependent, and a quantitative understanding and categorization of these risks can only be made possible through broad participation and deliberation of stakeholders, with the use of site-specific, process-based models as the decision basis. Online decision making, however, requires that scenarios be run in real time. In this work, a Python based, Leakage Assessment and Cost Estimation (PyLACE) web application was developed for quantifying financial risks associated with potential leakage from geologic carbon sequestration sites. PyLACE aims to assist a collaborative, analytic-deliberative decision making processes by automating metamodel creation, knowledge sharing, and online collaboration. In PyLACE, metamodeling, which is a process of developing faster-to-run surrogates of process-level models, is enabled using a special stochastic response surface method and the Gaussian process regression. Both methods allow consideration of model parameter uncertainties and the use of that information to generate confidence intervals on model outputs. Training of the metamodels is delegated to a high performance computing cluster and is orchestrated by a set of asynchronous job scheduling tools for job submission and result retrieval. As a case study, workflow and main features of PyLACE are demonstrated using a multilayer, carbon storage model.

Open challenges in structure-based virtual screening: Receptor modeling, target flexibility consideration and active site water molecules description.

PubMed

Spyrakis, Francesca; Cavasotto, Claudio N

2015-10-01

Structure-based virtual screening is currently an established tool in drug lead discovery projects. Although in the last years the field saw an impressive progress in terms of algorithm development, computational performance, and retrospective and prospective applications in ligand identification, there are still long-standing challenges where further improvement is needed. In this review, we consider the conceptual frame, state-of-the-art and recent developments of three critical "structural" issues in structure-based drug lead discovery: the use of homology modeling to accurately model the binding site when no experimental structures are available, the necessity of accounting for the dynamics of intrinsically flexible systems as proteins, and the importance of considering active site water molecules in lead identification and optimization campaigns. Copyright © 2015 Elsevier Inc. All rights reserved.

The JINR Tier1 Site Simulation for Research and Development Purposes

NASA Astrophysics Data System (ADS)

Korenkov, V.; Nechaevskiy, A.; Ososkov, G.; Pryahina, D.; Trofimov, V.; Uzhinskiy, A.; Voytishin, N.

2016-02-01

Distributed complex computing systems for data storage and processing are in common use in the majority of modern scientific centers. The design of such systems is usually based on recommendations obtained via a preliminary simulated model used and executed only once. However big experiments last for years and decades, and the development of their computing system is going on, not only quantitatively but also qualitatively. Even with the substantial efforts invested in the design phase to understand the systems configuration, it would be hard enough to develop a system without additional research of its future evolution. The developers and operators face the problem of the system behaviour predicting after the planned modifications. A system for grid and cloud services simulation is developed at LIT (JINR, Dubna). This simulation system is focused on improving the effciency of the grid/cloud structures development by using the work quality indicators of some real system. The development of such kind of software is very important for making a new grid/cloud infrastructure for such big scientific experiments like the JINR Tier1 site for WLCG. The simulation of some processes of the Tier1 site is considered as an example of our application approach.

Development of a mixed shrub–ponderosa pine community in a natural and treated condition

Treesearch

Philip M. McDonald; Gary O. Fiddler

1995-01-01

On a medium site in northern California, a mostly shrub community was treated by two manual release techniques and by two herbicides, to study its development in both a natural (control) and treated condition. Survival and growth of planted ponderosa pine seedlings were quantified for 8 to 11 years after initial treatment applications. Treatments included manual...

Developing and Testing an Online Tool for Teaching GIS Concepts Applied to Spatial Decision-Making

ERIC Educational Resources Information Center

Carver, Steve; Evans, Andy; Kingston, Richard

2004-01-01

The development and testing of a Web-based GIS e-learning resource is described. This focuses on the application of GIS for siting a nuclear waste disposal facility and the associated principles of spatial decision-making using Boolean and weighted overlay methods. Initial student experiences in using the system are analysed as part of a research…

The role of information communication technology (ICT) towards universal health coverage: the first steps of a telemedicine project in Ethiopia.

PubMed

Shiferaw, Fassil; Zolfo, Maria

2012-01-01

Eighty-five per cent of the Ethiopian population lives in remote areas, without access to modern health services. The limited health care budget, chronic shortage of health care workers and lack of incentives to retain those in remote areas further jeopardize the national health care delivery system. Recently, the application of information communication technology (ICT) to health care delivery and the use of telemedicine have raised hopes. This paper analyzes the challenges, failures and successes encountered in setting-up and implementing a telemedicine program in Ethiopia and provides possible recommendations for developing telemedicine strategies in countries with limited resources. Ten sites in Ethiopia were selected to participate in this pilot between 2004 and 2006 and twenty physicians, two per site, were trained in the use of a store and forward telemedicine system, using a dial-up internet connection. Teledermatology, teleradiology and telepathology were the chosen disciplines for the electronic referrals, across the selected ten sites. Telemedicine implementation does not depend only on technological factors, rather on e-government readiness, enabling policies, multisectoral involvement and capacity building processes. There is no perfect 'one size fits all' technology and the use of combined interoperable applications, according to the local context, is highly recommended. Telemedicine is still in a premature phase of development in Ethiopia and other sub-Saharan African countries, and it remains difficult to talk objectively about measurable impact of its use, even though it has demonstrated practical applicability beyond reasonable doubts.

Brownfields to green fields: Realising wider benefits from practical contaminant phytomanagement strategies.

PubMed

Cundy, A B; Bardos, R P; Puschenreiter, M; Mench, M; Bert, V; Friesl-Hanl, W; Müller, I; Li, X N; Weyens, N; Witters, N; Vangronsveld, J

2016-12-15

Gentle remediation options (GROs) are risk management strategies or technologies involving plant (phyto-), fungi (myco-), and/or bacteria-based methods that result in a net gain (or at least no gross reduction) in soil function as well as effective risk management. GRO strategies can be customised along contaminant linkages, and can generate a range of wider economic, environmental and societal benefits in contaminated land management (and in brownfields management more widely). The application of GROs as practical on-site remedial solutions is still limited however, particularly in Europe and at trace element (typically metal and metalloid) contaminated sites. This paper discusses challenges to the practical adoption of GROs in contaminated land management, and outlines the decision support tools and best practice guidance developed in the European Commission FP7-funded GREENLAND project aimed at overcoming these challenges. The GREENLAND guidance promotes a refocus from phytoremediation to wider GROs- or phyto-management based approaches which place realisation of wider benefits at the core of site design, and where gentle remediation technologies can be applied as part of integrated, mixed, site risk management solutions or as part of "holding strategies" for vacant sites. The combination of GROs with renewables, both in terms of biomass generation but also with green technologies such as wind and solar power, can provide a range of economic and other benefits and can potentially support the return of low-level contaminated sites to productive usage, while combining GROs with urban design and landscape architecture, and integrating GRO strategies with sustainable urban drainage systems and community gardens/parkland (particularly for health and leisure benefits), has large potential for triggering GRO application and in realising wider benefits in urban and suburban systems. Quantifying these wider benefits and value (above standard economic returns) will be important in leveraging funding for GRO application and soft site end-use more widely at vacant or underutilized sites. Copyright © 2016 Elsevier Ltd. All rights reserved.

Health system reform and the role of field sites based upon demographic and health surveillance.

PubMed Central

Tollman, S. M.; Zwi, A. B.

2000-01-01

Field sites for demographic and health surveillance have made well-recognized contributions to the evaluation of new or untested interventions, largely through efficacy trials involving new technologies or the delivery of selected services, e.g. vaccines, oral rehydration therapy and alternative contraceptive methods. Their role in health system reform, whether national or international, has, however, proved considerably more limited. The present article explores the characteristics and defining features of such field sites in low-income and middle-income countries and argues that many currently active sites have a largely untapped potential for contributing substantially to national and subnational health development. Since the populations covered by these sites often correspond with the boundaries of districts or subdistricts, the strategic use of information generated by demographic surveillance can inform the decentralization efforts of national and provincial health authorities. Among the areas of particular importance are the following: making population-based information available and providing an information resource; evaluating programmes and interventions; and developing applications to policy and practice. The question is posed as to whether their potential contribution to health system reform justifies arguing for adaptations to these field sites and expanded investment in them. PMID:10686747

Participatory Training to Improve Safety and Health in Small Construction Sites in Some Countries in Asia: Development and Application of the WISCON Training Program.

PubMed

Kawakami, Tsuyoshi

2016-08-01

A participatory training program, Work Improvement in Small Construction Sites, was developed to provide practical support measures to the small construction sector. Managers and workers from selected small sites were interviewed about their occupational safety and health risks. The Work Improvement in Small Construction Sites training program comprised a 45-item action checklist, photos, and illustrations showing local examples and group work methods. Pilot training workshops were carried out with workers and employers in Cambodia, Laos, Mongolia, Thailand, and Vietnam. Participants subsequently planned, and using locally available low-cost materials, implemented their own improvements such as hand-made hand trucks to carry heavy materials, removal of projecting nails from timber materials, and fences to protect roof workers from falling. Local Work Improvement in Small Construction Sites trainers consisting of government officials, workers, employers, and nongovernment organization representatives were then trained to implement the Work Improvement in Small Construction Sites training widely. Keys to success were easy-to-apply training tools aiming at immediate, low-cost improvements, and collaboration with various local people's networks. © The Author(s) 2016.

An Advanced Reservoir Simulator for Tracer Transport in Multicomponent Multiphase Compositional Flow and Applications to the Cranfield CO2 Sequestration Site

NASA Astrophysics Data System (ADS)

Moortgat, J.

2015-12-01

Reservoir simulators are widely used to constrain uncertainty in the petrophysical properties of subsurface formations by matching the history of injection and production data. However, such measurements may be insufficient to uniquely characterize a reservoir's properties. Monitoring of natural (isotopic) and introduced tracers is a developing technology to further interrogate the subsurface for applications such as enhanced oil recovery from conventional and unconventional resources, and CO2 sequestration. Oak Ridge National Laboratory has been piloting this tracer technology during and following CO2 injection at the Cranfield, Mississippi, CO2 sequestration test site. Two campaigns of multiple perfluorocarbon tracers were injected together with CO2 and monitored at two wells at 68 m and 112 m from the injection site. The tracer data suggest that multiple CO2 flow paths developed towards the monitoring wells, indicative of either channeling through high permeability pathways or of fingering. The results demonstrate that tracers provide an important complement to transient pressure data. Numerical modeling is essential to further explain and interpret the observations. To aid the development of tracer technology, we enhanced a compositional multiphase reservoir simulator to account for tracer transport. Our research simulator uses higher-order finite element (FE) methods that can capture the small-scale onset of fingering on the coarse grids required for field-scale modeling, and allows for unstructured grids and anisotropic heterogeneous permeability fields. Mass transfer between fluid phases and phase behavior are modeled with rigorous equation-of-state based phase-split calculations. We present our tracer simulator and preliminary results related to the Cranfield experiments. Applications to noble gas tracers in unconventional resources are presented by Darrah et al.

Develop and test fuel cell powered on-site integrated total energy system

NASA Technical Reports Server (NTRS)

Kaufman, A.; Feigenbaum, H.; Wang, C. L.; Werth, J.; Whelan, J. A.

1983-01-01

Test results are presented for a 24 cell, two sq ft (4kW) stack. This stack is a precursor to a 25kW stack that is a key milestone. Results are discussed in terms of cell performance, electrolyte management, thermal management, and reactant gas manifolding. The results obtained in preliminary testing of a 50kW methanol processing subsystem are discussed. Subcontracting activities involving application analysis for fuel cell on site integrated energy systems are updated.

Progress toward a circulation atlas for application to coastal water siting problems

NASA Technical Reports Server (NTRS)

Munday, J. C., Jr.; Gordon, H. H.

1978-01-01

Circulation data needed to resolve coastal siting problems are assembled from historical hydrographic and remote sensing studies in the form of a Circulation Atlas. Empirical data are used instead of numerical model simulations to achieve fine resolution and include fronts and convergence zones. Eulerian and Langrangian data are collected, transformed, and combined into trajectory maps and current vector maps as a function of tidal phase and wind vector. Initial Atlas development is centered on the Elizabeth River, Hampton Roads, Virgina.

Site-Specific Infrared Probes of Proteins

PubMed Central

Ma, Jianqiang; Pazos, Ileana M.; Zhang, Wenkai; Culik, Robert M.; Gai, Feng

2015-01-01

Infrared spectroscopy has played an instrumental role in studying a wide variety of biological questions. However, in many cases it is impossible or difficult to rely on the intrinsic vibrational modes of biological molecules of interest, such as proteins, to reveal structural and/or environmental information in a site-specific manner. To overcome this limitation, many recent efforts have been dedicated to the development and application of various extrinsic vibrational probes that can be incorporated into biological molecules and used to site-specifically interrogate their structural and/or environmental properties. In this Review, we highlight some recent advancements of this rapidly growing research area. PMID:25580624

U.S. Geological Survey research in radioactive waste disposal - Fiscal years 1986-1990

USGS Publications Warehouse

Trask, N.J.; Stevens, P.R.

1991-01-01

The report summarizes progress on geologic and hydrologic research related to the disposal of radioactive wastes. The research efforts are categorized according to whether they are related most directly to: (1) high-level wastes, (2) transuranic wastes, (3) low-level and mixed low-level and hazardous wastes, or (4) uranium mill tailings. Included is research applicable to the identification and geohydrologic characterization of waste-disposal sites, to investigations of specific sites where wastes have been stored, to development of techniques and methods for characterizing disposal sites, and to studies of geologic and hydrologic processes related to the transport and/or retention of waste radionuclides.

Engineering peptide ligase specificity by proteomic identification of ligation sites.

PubMed

Weeks, Amy M; Wells, James A

2018-01-01

Enzyme-catalyzed peptide ligation is a powerful tool for site-specific protein bioconjugation, but stringent enzyme-substrate specificity limits its utility. We developed an approach for comprehensively characterizing peptide ligase specificity for N termini using proteome-derived peptide libraries. We used this strategy to characterize the ligation efficiency for >25,000 enzyme-substrate pairs in the context of the engineered peptide ligase subtiligase and identified a family of 72 mutant subtiligases with activity toward N-terminal sequences that were previously recalcitrant to modification. We applied these mutants individually for site-specific bioconjugation of purified proteins, including antibodies, and in algorithmically selected combinations for sequencing of the cellular N terminome with reduced sequence bias. We also developed a web application to enable algorithmic selection of the most efficient subtiligase variant(s) for bioconjugation to user-defined sequences. Our methods provide a new toolbox of enzymes for site-specific protein modification and a general approach for rapidly defining and engineering peptide ligase specificity.

RIPiT-Seq: A high-throughput approach for footprinting RNA:protein complexes

PubMed Central

Singh, Guramrit; Ricci, Emiliano P.; Moore, Melissa J.

2013-01-01

Development of high-throughput approaches to map the RNA interaction sites of individual RNA binding proteins (RBPs) transcriptome-wide is rapidly transforming our understanding of post-transcriptional gene regulatory mechanisms. Here we describe a ribonucleoprotein (RNP) footprinting approach we recently developed for identifying occupancy sites of both individual RBPs and multi-subunit RNP complexes. RNA:protein immunoprecipitation in tandem (RIPiT) yields highly specific RNA footprints of cellular RNPs isolated via two sequential purifications; the resulting RNA footprints can then be identified by high-throughput sequencing (Seq). RIPiT-Seq is broadly applicable to all RBPs regardless of their RNA binding mode and thus provides a means to map the RNA binding sites of RBPs with poor inherent ultraviolet (UV) crosslinkability. Further, among current high-throughput approaches, RIPiT has the unique capacity to differentiate binding sites of RNPs with overlapping protein composition. It is therefore particularly suited for studying dynamic RNP assemblages whose composition evolves as gene expression proceeds. PMID:24096052

Automated container transportation using self-guided vehicles: Fernald site requirements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hazen, F.B.

1993-09-01

A new opportunity to improve the safety and efficiency of environmental restoration operations, using robotics has emerged from advances in industry, academia, and government labs. Self-Guided Vehicles (SGV`s) have recently been developed in industry and early systems have already demonstrated much, though not all, of the functionality necessary to support driverless transportation of waste within and between processing facilities. Improved materials databases are being developed by at least two DOE remediation sites, the Fernald Environmental Management Project (FEME) in the State of Ohio and the Hanford Complex in the State of Washington. SGV`s can be developed that take advantage ofmore » the information in these databases and yield improved dispatch, waste tracking, report and shipment documentation. In addition, they will reduce the radiation hazard to workers and the risk of damaging containers through accidental collision. In this document, features of remediation sites that dictate the design of both the individual SGV`s and the collective system of SGV`s are presented, through the example of the site requirements at Fernald. Some concepts borrowed from the world of manufacturing are explained and then used to develop an integrated, holistic view of the remediation site as a pseudo-factory. Transportation methods at Fernald and anticipated growth in transport demand are analyzed. The new site-wide database under development at Fernald is presented so that advantageous and synergistic links between SGV`s and information systems can be analyzed. Details of the SGV development proposed are submitted, and some results of a recently completed state of the art survey for SGV use in this application are also presented.« less

Glycopeptide Analysis, Recent Developments and Applications*

PubMed Central

Desaire, Heather

2013-01-01

Glycopeptide-based analysis is used to inform researchers about the glycans on one or more proteins. The method's key attractive feature is its ability to link glycosylation information to exact locations (glycosylation sites) on proteins. Numerous applications for glycopeptide analysis are known, and several examples are described herein. The techniques used to characterize glycopeptides are still emerging, and recently, research focused on facilitating aspects of glycopeptide analysis has advanced significantly in the areas of sample preparation, MS fragmentation, and automation of data analysis. These recent developments, described herein, provide the foundation for the growth of glycopeptide analysis as a blossoming field. PMID:23389047

Design of Single-Site Photocatalyst using Metal-Organic Framework as Matrix.

PubMed

Wen, Meicheng; Mori, Kohsuke; Kuwahara, Yasutaka; An, Taicheng; Yamashita, Hiromi

2018-05-14

Single-site photocatalyst generally displays excellent photocatalytic activtiy and considerable high stability as compared to homogeneous catalytic system. A rational structural design of single-site photocatalyst with isolated, uniform and spatially separated active sites in a given solid is of prime importance to achieve high photocatalytic activity. Intense attentions have been focused on the engineering and fabrication of single-site photocatalys by using porous materials as platform. Metal-organic frameworks (MOFs) hold great potential for the design and fabrication of single-site photocatalysts due to their remarkable porosity, ultrahigh surface area, extraordinary tailorability and significant diversity. MOFs can provide abundant number of binding sites for anchoring active sites, result in significant enhancement of photocatalytic performance. In this focus review, the development of single-site MOF photocatalysts that perform in important and challenging chemical redox reaction such as photocatalytic water splitting, photocatalytic CO₂ conversion and organic transformations is summarized thoroughly. The successful strategies applied for the construction of single-site MOF photocatalysts and major challenge toward practical application was summarized and pointed out, respectively. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Waste Information Management System with 2012-13 Waste Streams - 13095

DOE Office of Scientific and Technical Information (OSTI.GOV)

Upadhyay, H.; Quintero, W.; Lagos, L.

2013-07-01

The Waste Information Management System (WIMS) 2012-13 was updated to support the Department of Energy (DOE) accelerated cleanup program. The schedule compression required close coordination and a comprehensive review and prioritization of the barriers that impeded treatment and disposition of the waste streams at each site. Many issues related to waste treatment and disposal were potential critical path issues under the accelerated schedule. In order to facilitate accelerated cleanup initiatives, waste managers at DOE field sites and at DOE Headquarters in Washington, D.C., needed timely waste forecast and transportation information regarding the volumes and types of radioactive waste that wouldmore » be generated by DOE sites over the next 40 years. Each local DOE site historically collected, organized, and displayed waste forecast information in separate and unique systems. In order for interested parties to understand and view the complete DOE complex-wide picture, the radioactive waste and shipment information of each DOE site needed to be entered into a common application. The WIMS application was therefore created to serve as a common application to improve stakeholder comprehension and improve DOE radioactive waste treatment and disposal planning and scheduling. WIMS allows identification of total forecasted waste volumes, material classes, disposition sites, choke points, technological or regulatory barriers to treatment and disposal, along with forecasted waste transportation information by rail, truck and inter-modal shipments. The Applied Research Center (ARC) at Florida International University (FIU) in Miami, Florida, developed and deployed the web-based forecast and transportation system and is responsible for updating the radioactive waste forecast and transportation data on a regular basis to ensure the long-term viability and value of this system. (authors)« less

Mapping suitability areas for concentrated solar power plants using remote sensing data

DOE PAGES

Omitaomu, Olufemi A.; Singh, Nagendra; Bhaduri, Budhendra L.

2015-05-14

The political push to increase power generation from renewable sources such as solar energy requires knowing the best places to site new solar power plants with respect to the applicable regulatory, operational, engineering, environmental, and socioeconomic criteria. Therefore, in this paper, we present applications of remote sensing data for mapping suitability areas for concentrated solar power plants. Our approach uses digital elevation model derived from NASA s Shuttle Radar Topographic Mission (SRTM) at a resolution of 3 arc second (approx. 90m resolution) for estimating global solar radiation for the study area. Then, we develop a computational model built on amore » Geographic Information System (GIS) platform that divides the study area into a grid of cells and estimates site suitability value for each cell by computing a list of metrics based on applicable siting requirements using GIS data. The computed metrics include population density, solar energy potential, federal lands, and hazardous facilities. Overall, some 30 GIS data are used to compute eight metrics. The site suitability value for each cell is computed as an algebraic sum of all metrics for the cell with the assumption that all metrics have equal weight. Finally, we color each cell according to its suitability value. Furthermore, we present results for concentrated solar power that drives a stream turbine and parabolic mirror connected to a Stirling Engine.« less

U.S. Seismic Design Maps Web Application

NASA Astrophysics Data System (ADS)

Martinez, E.; Fee, J.

2015-12-01

The application computes earthquake ground motion design parameters compatible with the International Building Code and other seismic design provisions. It is the primary method for design engineers to obtain ground motion parameters for multiple building codes across the country. When designing new buildings and other structures, engineers around the country use the application. Users specify the design code of interest, location, and other parameters to obtain necessary ground motion information consisting of a high-level executive summary as well as detailed information including maps, data, and graphs. Results are formatted such that they can be directly included in a final engineering report. In addition to single-site analysis, the application supports a batch mode for simultaneous consideration of multiple locations. Finally, an application programming interface (API) is available which allows other application developers to integrate this application's results into larger applications for additional processing. Development on the application has proceeded in an iterative manner working with engineers through email, meetings, and workshops. Each iteration provided new features, improved performance, and usability enhancements. This development approach positioned the application to be integral to the structural design process and is now used to produce over 1800 reports daily. Recent efforts have enhanced the application to be a data-driven, mobile-first, responsive web application. Development is ongoing, and source code has recently been published into the open-source community on GitHub. Open-sourcing the code facilitates improved incorporation of user feedback to add new features ensuring the application's continued success.

Aquarius Radiometer and Scatterometer Weekly Polar-Gridded Products to Monitor Ice Sheets, Sea Ice, and Frozen Soil

NASA Technical Reports Server (NTRS)

Brucker, Ludovic; Dinnat, Emmanuel; Koenig, Lora

2014-01-01

Space-based microwave sensors have been available for several decades, and with time more frequencies have been offered. Observations made at frequencies between 7 and 183 GHz were often used for monitoring cryospheric properties (e.g. sea ice concentration, snow accumulation, snow melt extent and duration). Since 2009, satellite observations are available at the low frequency of 1.4 GHz. Such observations are collected by the Soil Moisture and Ocean Salinity (SMOS) mission, and the Aquarius/SAC-D mission. Even though these missions have been designed for the monitoring of soil moisture and sea surface salinity, new applications are being developed to study the cryosphere. For instance, L-band observations can be used to monitor soil freeze/thaw (e.g. Rautiainen et al., 2012), and thin sea ice thickness (e.g. Kaleschke et al., 2010, Huntemann et al., 2013). Moreover, with the development of satellite missions comes the need for calibration and validation sites. These sites must have stable characteristics, such as the Antarctic Plateau (Drinkwater et al., 2004, Macelloni et al., 2013). Therefore, studying the cryosphere with 1.4 GHz observations is relevant for both science applications, and remote sensing applications.

Aquarius Radiometer and Scatterometer Weekly-Polar-Gridded Products to Monitor Ice Sheets, Sea Ice, and Frozen Soil

NASA Technical Reports Server (NTRS)

Brucker, Ludovic; Dinnat, Emmanuel; Koenig, Lora

2014-01-01

Space-based microwave sensors have been available for several decades, and with time more frequencies have been offered. Observations made at frequencies between 7 and 183 GHz were often used for monitoring cryospheric properties (e.g. sea ice concentration, snow accumulation, snow melt extent and duration). Since 2009, satellite observations are available at the low frequency of 1.4 GHz. Such observations are collected by the Soil Moisture and Ocean Salinity (SMOS) mission, and the AquariusSAC-D mission. Even though these missions have been designed for the monitoring of soil moisture and sea surface salinity, new applications are being developed to study the cryosphere. For instance, L-band observations can be used to monitor soil freezethaw (e.g. Rautiainen et al., 2012), and thin sea ice thickness (e.g. Kaleschke et al., 2010, Huntemann et al., 2013). Moreover, with the development of satellite missions comes the need for calibration and validation sites. These sites must have stable characteristics, such as the Antarctic Plateau (Drinkwater et al., 2004, Macelloni et al., 2013). Therefore, studying the cryosphere with 1.4 GHz observations is relevant for both science applications, and remote sensing applications.

Double-u double-u double-u dot APIC dot org: a review of the APIC World Wide Web site.

PubMed

Harr, J

1996-12-01

The widespread use of the Internet and the development of the World Wide Web have led to a revolution in electronic communication and information access. The Association for Professional in Infection Control and Epidemiology (APIC) has developed a site on the World Wide Web to provide mechanisms for international on-line information access and exchange on issues related to the practice of infection control and the application of epidemiology. From the home page of the APIC Web site, users can access information on professional resources, publications, educational offering, governmental affairs, the APIC organization, and the infection control profession. Among the chief features of the site is a discussion forum for posing questions and sharing information about infection control and epidemiology. The site also contains a searchable database of practice-related abstracts and descriptions and order forms for APIC publications. Users will find continuing education course descriptions and registration forms, legislative and regulatory action alerts and a congressional mailer, chapter and committee information, and infection control information of interest to the general public. APIC is considering several potential future enhancements to their Web site and will continue to review the site's content and features to provide current and useful information to infection control professionals.

Rock Hill Business, Education, and Community Online Network.

ERIC Educational Resources Information Center

Broyles, Alan

The Business, Education & Community On-line Network (BEACON) is designed to support development and implementation of demonstration applications operating in an asynchronous transfer mode (ATM) fiber optic network environment. Initial origination and destination sites include high schools and universities around Rock Hill (South Carolina). The…

40 CFR 60.4880 - How do I develop a site-specific monitoring plan for my continuous monitoring, bag leak detection...

Code of Federal Regulations, 2012 CFR

2012-07-01

... section are met. (A) The zero (low-level), mid-level (if applicable), or high-level calibration drift... representative of the relative or absolute particulate matter loadings for each exhaust stack, roof vent, or...

40 CFR 60.4880 - How do I develop a site-specific monitoring plan for my continuous monitoring, bag leak detection...

Code of Federal Regulations, 2014 CFR

2014-07-01

... section are met. (A) The zero (low-level), mid-level (if applicable), or high-level calibration drift... representative of the relative or absolute particulate matter loadings for each exhaust stack, roof vent, or...

40 CFR 60.4880 - How do I develop a site-specific monitoring plan for my continuous monitoring, bag leak detection...

Code of Federal Regulations, 2013 CFR

2013-07-01

... section are met. (A) The zero (low-level), mid-level (if applicable), or high-level calibration drift... representative of the relative or absolute particulate matter loadings for each exhaust stack, roof vent, or...

Acceptability of smartphone application-based HIV prevention among young men who have sex with men.

PubMed

Holloway, Ian W; Rice, Eric; Gibbs, Jeremy; Winetrobe, Hailey; Dunlap, Shannon; Rhoades, Harmony

2014-02-01

Young men who have sex with men (YMSM) are increasingly using mobile smartphone applications ("apps"), such as Grindr, to meet sex partners. A probability sample of 195 Grindr-using YMSM in Southern California were administered an anonymous online survey to assess patterns of and motivations for Grindr use in order to inform development and tailoring of smartphone-based HIV prevention for YMSM. The number one reason for using Grindr (29 %) was to meet "hook ups." Among those participants who used both Grindr and online dating sites, a statistically significantly greater percentage used online dating sites for "hook ups" (42 %) compared to Grindr (30 %). Seventy percent of YMSM expressed a willingness to participate in a smartphone app-based HIV prevention program. Development and testing of smartphone apps for HIV prevention delivery has the potential to engage YMSM in HIV prevention programming, which can be tailored based on use patterns and motivations for use.

The application of quantum mechanics in structure-based drug design.

PubMed

Mucs, Daniel; Bryce, Richard A

2013-03-01

Computational chemistry has become an established and valuable component in structure-based drug design. However the chemical complexity of many ligands and active sites challenges the accuracy of the empirical potentials commonly used to describe these systems. Consequently, there is a growing interest in utilizing electronic structure methods for addressing problems in protein-ligand recognition. In this review, the authors discuss recent progress in the development and application of quantum chemical approaches to modeling protein-ligand interactions. The authors specifically consider the development of quantum mechanics (QM) approaches for studying large molecular systems pertinent to biology, focusing on protein-ligand docking, protein-ligand binding affinities and ligand strain on binding. Although computation of binding energies remains a challenging and evolving area, current QM methods can underpin improved docking approaches and offer detailed insights into ligand strain and into the nature and relative strengths of complex active site interactions. The authors envisage that QM will become an increasingly routine and valued tool of the computational medicinal chemist.

Acceptability of Smartphone Application-Based HIV Prevention Among Young Men Who Have Sex With Men

PubMed Central

Holloway, Ian W.; Rice, Eric; Gibbs, Jeremy; Winetrobe, Hailey; Dunlap, Shannon; Rhoades, Harmony

2014-01-01

Young men who have sex with men (YMSM) are increasingly using mobile smartphone applications (“apps”), such as Grindr, to meet sex partners. A probability sample of 195 Grindrusing YMSM in Southern California were administered an anonymous online survey to assess patterns of and motivations for Grindr use in order to inform development and tailoring of smartphone-based HIV prevention for YMSM. The number one reason for using Grindr (29%) was to meet “hook ups.” Among those participants who used both Grindr and online dating sites, a statistically significantly greater percentage used online dating sites for “hook ups” (42%) compared to Grindr (30%). Seventy percent of YMSM expressed a willingness to participate in a smartphone app-based HIV prevention program. Development and testing of smartphone apps for HIV prevention delivery has the potential to engage YMSM in HIV prevention programming, which can be tailored based on use patterns and motivations for use. PMID:24292281

Clean-ups at Aberdeen Proving Ground

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardenuto, R.A.

1994-12-31

The Department of Defense has utilized radiative material in numerous applications over several decades. Aberdeen Proving Ground has been an integral player in the Army`s Research, Development, and Testing of items incorporating radionuclides, as well as developing new and innovative applications. As new information becomes available and society progresses, we find that the best management practices used decades, or even sometimes years earlier are inadequate to meet the current demands. Aberdeen Proving Ground is committed to remediating historic disposal sites, and utilizing the best available technology in current operations to prevent future adverse impact. Two projects which are currently ongoingmore » at Aberdeen Proving Ground illustrates these points. The first, the remediation of contaminated metal storage areas, depicts how available technology has provided a means for recycling material whereby preventing the continued stock piling, and allowing for the decommissioning of the areas. The second, the 26Th Street Disposal Site Removal Action, shows how historic methods of disposition were inadequate to meet today`s needs.« less

Ultra-fast DNA-based multiplex convection PCR method for meat species identification with possible on-site applications.

PubMed

Song, Kyung-Young; Hwang, Hyun Jin; Kim, Jeong Hee

2017-08-15

The aim of this study was to develop an ultra-fast molecular detection method for meat identification using convection Palm polymerase chain reaction (PCR). The mitochondrial cytochrome b (Cyt b) gene was used as a target gene. Amplicon size was designed to be different for beef, lamb, and pork. When these primer sets were used, each species-specific set specifically detected the target meat species in singleplex and multiplex modes in a 24min PCR run. The detection limit was 1pg of DNA for each meat species. The convection PCR method could detect as low as 1% of meat adulteration. The stability of the assay was confirmed using thermal processed meats. We also showed that direct PCR can be successfully performed with mixed meats and food samples. These results suggest that the developed assay may be useful in the authentication of meats and meat products in laboratory and rapid on-site applications. Copyright © 2017 Elsevier Ltd. All rights reserved.

Site Characterization Technologies for DNAPL Investigations

EPA Pesticide Factsheets

This document is intended to help managers at sites with potential or confirmed DNAPL contamination identify suitable characterization technologies, screen the technologies for potential application, learn about applications at similar sites, and...

75 FR 27982 - Foreign-Trade Zone 14-Little Rock, Arkansas Application for Reorganization/Expansion Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

... Rock, Arkansas Application for Reorganization/Expansion Under Alternative Site Framework An application... current zone project includes the following sites: Site 1 (759.48 acres)--located at the Little Rock Port... of the Little Rock Port Industrial Park, on the McClellan-Kerr Arkansas River Navigation System...

Application of micro-solid-phase extraction for the on-site extraction of heterocyclic aromatic amines in seawater.

PubMed

Basheer, Chanbasha

2018-04-01

An efficient on-site extraction technique to determine carcinogenic heterocyclic aromatic amines in seawater has been reported. A micro-solid-phase extraction device placed inside a portable battery-operated pump was used for the on-site extraction of seawater samples. Before on-site applications, parameters that influence the extraction efficiency (extraction time, type of sorbent materials, suitable desorption solvent, desorption time, and sample volume) were investigated and optimized in the laboratory. The developed method was then used for the on-site sampling of heterocyclic aromatic amines determination in seawater samples close to distillation plant. Once the on-site extraction completed, the small extraction device with the analytes was brought back to the laboratory for analysis using high-performance liquid chromatography with fluorescence detection. Based on the optimized conditions, the calibration curves were linear over the concentration range of 0.05-20 μg/L with correlation coefficients up to 0.996. The limits of detection were 0.004-0.026 μg/L, and the reproducibility values were between 1.3 and 7.5%. To evaluate the extraction efficiency, a comparison was made with conventional solid-phase extraction and it was applied to various fortified real seawater samples. The average relative recoveries obtained from the spiked seawater samples varied in the range 79.9-95.2%. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Glass Property Models, Constraints, and Formulation Approaches for Vitrification of High-Level Nuclear Wastes at the US Hanford Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Dong-Sang

2015-03-02

The legacy nuclear wastes stored in underground tanks at the US Department of Energy’s Hanford site is planned to be separated into high-level waste and low-activity waste fractions and vitrified separately. Formulating optimized glass compositions that maximize the waste loading in glass is critical for successful and economical treatment and immobilization of nuclear wastes. Glass property-composition models have been developed and applied to formulate glass compositions for various objectives for the past several decades. The property models with associated uncertainties and combined with composition and property constraints have been used to develop preliminary glass formulation algorithms designed for vitrification processmore » control and waste form qualification at the planned waste vitrification plant. This paper provides an overview of current status of glass property-composition models, constraints applicable to Hanford waste vitrification, and glass formulation approaches that have been developed for vitrification of hazardous and highly radioactive wastes stored at the Hanford site.« less

Analysis of Alternative (Low Impact) Development on a Theoretical Residential Development in North Central Florida

NASA Astrophysics Data System (ADS)

Wise, W. R.

2001-05-01

Research currently in progress will evaluate land development options on a 161 +/- HA site in North Central Florida lying within a 292+/- HA watershed that contributes to Bullfrog Creek in the Camp Blanding Wildlife Management Area. The research analyzes aspects of an emerging storm-water management philosophy, called low-impact development (LID) by Prince Georges County, Maryland. LID seeks to preserve site hydrology by reducing the area of disturbance on the site, preserving natural drainage features on the site and by utilizing BMPs that promote infiltration and slower transport of runoff. This research investigates the benefits and problems associated with this design philosophy, particularly in Florida. Two scenarios will be investigated: Low density residential and Medium density residential. Within each scenario the hydrologic response of the site under conventional and LID will be explored. Furthermore, the impact of using cluster developments in LIDs will be investigated. Parameters to be measured include: peak flow, runoff volume, pollutant load generated/removed by BMPs, peak-flow timing and base flow. HEC-HMS will be used for hydrologic modeling (soil moisture accounting module). Pollutant loads generated and removed will be based on published data for land use and BMPs. An economic analysis, based on the estimated construction costs of conventional and LID, will also be done. Further sensitivity analyses will be conducted on the effect that various watershed conditions have on the hydrologic response of the site developed as a LID. This research will provide insight to several questions. In the most general sense it will indicate whether this emerging design philosophy, much of which was developed in other regions of the country, is beneficial to Florida watersheds "as it is" and what, if any, alterations should be considered. Secondly, this research will show the impact of development with different site-planning options, for example cluster development versus deed restrictions on lots. Thirdly, the research will give insight to the applicability of this land-development approach under different allowable residential densities. Lastly, the effect of different physical characteristics on the watershed can be explored.

Developing internet-based eHealth promotion programs: the Spiral Technology Action Research (STAR) model.

PubMed

Skinner, Harvey A; Maley, Oonagh; Norman, Cameron D

2006-10-01

Health education and health promotion have a tradition of using information and communication technology (ICT). In recent years, the rapid growth of the Internet has created innovative opportunities for Web-based health education and behavior change applications-termed eHealth promotion. However, many eHealth promotion applications are developed without an explicit model to guide the design, evaluation, and ongoing improvement of the program. The spiral technology action research (STAR) model was developed to address this need. The model comprises five cycles (listen, plan, do, study, act) that weave together technological development, community involvement, and continuous improvement. The model is illustrated by a case study describing the development of the Smoking Zine (www.SmokingZine.org), a youth smoking prevention and cessation Web site.

The TDR Tuberculosis Specimen Bank: a resource for diagnostic test developers.

PubMed

Nathanson, C-M; Cuevas, L E; Cunningham, J; Perkins, M D; Peeling, R W; Guillerm, M; Moussy, F; Ramsay, A

2010-11-01

The Special Programme for Research and Training in Tropical Diseases established a specimen bank in 1999 to support the development and evaluation of new tuberculosis (TB) diagnostic tools. To provide a narrative of the bank's development and discuss lessons learned, the bank's limitations and potential future applications. Collection sites were selected in high- and low-prevalence settings. Patients with TB symptoms, consenting to participate and to undergo human immunodeficiency virus testing were enrolled and diagnosed. Serum, sputum, saliva and urine samples were collected and sent to the bank's repositories. The bank has stocked 41,437 samples from 2524 patients at 11 sites worldwide. Ninety-five requests for specimens have been reviewed and 67 sets have been approved. Approved applicants have received sets of 20 or 200 samples. The bank allowed an evaluation of 19 commercial lateral flow tests and showed that none of them had broad global utility for TB diagnosis. The establishment and development of the specimen bank have provided a wealth of experience. It is fulfilling a need to provide quality specimens, but the type and number of samples may not fulfil the demands of future end-users. Plans are underway to review the mechanisms of specimen collection and distribution to maximise their impact on product development.

The application of consequence models in risk assessment: A regulator`s view

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nussey, C.; Carter, D.A.; Cassidy, K.

1995-12-31

Quantified risk assessment (QRA) is a technique for aiding decision making. The UK Health and Safety Executive (HSE) uses QRA in the Major Hazards (MH) area to formulate advice to Local Planning Authorities (LPAs) on the siting of MH installations and the development of land in the vicinity of existing MH installations. The region around UK MH sites within which LPAs are required to consult HSE on land-use planning matters (i.e. the Consultation Distance (CD)) is increasingly being redefined by adopting a risk based approach. The authors are now in the process of conducting or updated site specific QRAs tomore » redefine CDs. This process enables them to identify risk reduction measures and discuss them with companies, taking into consideration the ALARP--as low as is reasonably practicable--philosophy. The paper outlines the basis of the QRAs and the role of consequence assessment models and procedures in this process, and illustrates by examples the setting of CDs and the application of the ALARP philosophy.« less

Magnitude and Frequency of Floods on Nontidal Streams in Delaware

USGS Publications Warehouse

Ries, Kernell G.; Dillow, Jonathan J.A.

2006-01-01

Reliable estimates of the magnitude and frequency of annual peak flows are required for the economical and safe design of transportation and water-conveyance structures. This report, done in cooperation with the Delaware Department of Transportation (DelDOT) and the Delaware Geological Survey (DGS), presents methods for estimating the magnitude and frequency of floods on nontidal streams in Delaware at locations where streamgaging stations monitor streamflow continuously and at ungaged sites. Methods are presented for estimating the magnitude of floods for return frequencies ranging from 2 through 500 years. These methods are applicable to watersheds exhibiting a full range of urban development conditions. The report also describes StreamStats, a web application that makes it easy to obtain flood-frequency estimates for user-selected locations on Delaware streams. Flood-frequency estimates for ungaged sites are obtained through a process known as regionalization, using statistical regression analysis, where information determined for a group of streamgaging stations within a region forms the basis for estimates for ungaged sites within the region. One hundred and sixteen streamgaging stations in and near Delaware with at least 10 years of non-regulated annual peak-flow data available were used in the regional analysis. Estimates for gaged sites are obtained by combining the station peak-flow statistics (mean, standard deviation, and skew) and peak-flow estimates with regional estimates of skew and flood-frequency magnitudes. Example flood-frequency estimate calculations using the methods presented in the report are given for: (1) ungaged sites, (2) gaged locations, (3) sites upstream or downstream from a gaged location, and (4) sites between gaged locations. Regional regression equations applicable to ungaged sites in the Piedmont and Coastal Plain Physiographic Provinces of Delaware are presented. The equations incorporate drainage area, forest cover, impervious area, basin storage, housing density, soil type A, and mean basin slope as explanatory variables, and have average standard errors of prediction ranging from 28 to 72 percent. Additional regression equations that incorporate drainage area and housing density as explanatory variables are presented for use in defining the effects of urbanization on peak-flow estimates throughout Delaware for the 2-year through 500-year recurrence intervals, along with suggestions for their appropriate use in predicting development-affected peak flows. Additional topics associated with the analyses performed during the study are also discussed, including: (1) the availability and description of more than 30 basin and climatic characteristics considered during the development of the regional regression equations; (2) the treatment of increasing trends in the annual peak-flow series identified at 18 gaged sites, with respect to their relations with maximum 24-hour precipitation and housing density, and their use in the regional analysis; (3) calculation of the 90-percent confidence interval associated with peak-flow estimates from the regional regression equations; and (4) a comparison of flood-frequency estimates at gages used in a previous study, highlighting the effects of various improved analytical techniques.

Geomechanical Framework for Secure CO 2 Storage in Fractured Reservoirs and Caprocks for Sedimentary Basins in theMidwest United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sminchak, Joel

This report presents final technical results for the project Geomechanical Framework for Secure CO 2 Storage in Fractured Reservoirs and Caprocks for Sedimentary Basins in the Midwest United States (DE-FE0023330). The project was a three-year effort consisting of seven technical tasks focused on defining geomechanical factors for CO 2 storage applications in deep saline rock formations in Ohio and the Midwest United States, because geomechancial issues have been identified as a significant risk factor for large-scale CO 2 storage applications. A basin-scale stress-strain analysis was completed to describe the geomechanical setting for rock formations of Ordovician-Cambrian age in Ohio andmore » adjacent areas of the Midwest United States in relation to geologic CO 2 storage applications. The tectonic setting, stress orientation-magnitude, and geomechanical and petrophysical parameters for CO 2 storage zones and caprocks in the region were cataloged. Ten geophysical image logs were analyzed for natural fractures, borehole breakouts, and drilling-induced fractures. The logs indicated mostly less than 10 fractures per 100 vertical feet in the borehole, with mostly N65E principal stress orientation through the section. Geophysical image logs and other logs were obtained for three wells located near the sites where specific models were developed for geomechanical simulations: Arches site in Boone County, Kentucky; Northern Appalachian Basin site in Chautauqua County, New York; and E-Central Appalachian Basin site in Tuscarawas County, Ohio. For these three wells, 9,700 feet of image logs were processed and interpreted to provide a systematic review of the distribution within each well of natural fractures, wellbore breakouts, faults, and drilling induced fractures. There were many borehole breakouts and drilling-induced tensile fractures but few natural fractures. Concentrated fractures were present at the Rome-basal sandstone and basal sandstone-Precambrian contacts at the Arches and East-Central Appalachian Basin sites. Geophysical logs were utilized to develop local-scale geologic models by determining geomechanical and petrophysical parameters within the geologic formations. These data were ported to coupled fluid-flow and reservoir geomechanics multi-phase CO 2 injection simulations. The models were developed to emphasize the geomechanical layers within the CO 2 storage zones and caprocks. A series of simulations were completed for each site to evaluate whether commercial-scale CO 2 could be safely injected into each site, given site-specific geologic and geomechanical controls. This involved analyzing the simulation results for the integrity of the caprock, intermediate, and reservoir zones, as well quantifying the areal uplift at the surface. Simulation results were also examined to ensure that the stress-stress perturbations were isolated within the subsurface, and that there was only limited upward migration of the CO 2. Simulations showed capacity to inject more than 10 million metric tons of CO 2 in a single well at the Arches and East Central Appalachian Basin sites without excessive geomechanical risks. Low-permeability rock layers at the Northern Appalachian Basin study area well resulted in very low CO 2 injection capacity. Fracture models developed for the sites suggests that the sites have sparse fracture network in the deeper Cambrian rocks. However, there were indicators in image logs of a moderate fracture matrix in the Rose Run Sandstone at the Northern Appalachian Basin site. Dual permeability fracture matrix simulations suggest the much higher injection rates may be feasible in the fractured interval. Guidance was developed for geomechanical site characterization in the areas of geophysical logging, rock core testing, well testing, and site monitoring. The guidance demonstrates that there is a suitable array of options for addressing geomechanical issues at CO 2 storage sites. Finally, a review of Marcellus and Utica-Point Pleasant shale gas wells and CO 2 storage intervals indicates that these items are vertically separated, except for the Oriskany sandstone and Marcellus wells in southwest Pennsylvania and northern West Virginia. Together, project results present a more realistic portrayal of geomechanical risk factors related to CO 2 storage for existing and future coal-fired power plants in Ohio.« less

Revealing the Secrets of Stonehenge Through the Application of Laser Scanning, Photogrammetry and Visualisation Techniques

NASA Astrophysics Data System (ADS)

Bryan, P. G.; Abbott, M.; Dodson, A. J.

2013-07-01

Stonehenge is perhaps the most famous prehistoric monument in the world. Begun as a simple earthwork enclosure, it was built in several stages with the unique lintelled stone circle being erected in the Neolithic period in around 2,500 BC. Today Stonehenge, together with Avebury and other associated sites, form the heart of a World Heritage Site (WHS) with a unique and dense concentration of outstanding prehistoric monuments. In 2011 English Heritage (EH) embarked on a new survey of the monument. Undertaken by the Greenhatch Group, a commercial survey company based near Derby, a combination of laser scanning and photogrammetric approaches were used to generate the required scale and detailed level of output required by English Heritage. This paper will describe the background to this project and its context within previous survey activities at this World Heritage Site. It will explain the data acquisition technology and processes undertaken on site, the datasets derived from post-processing and their filtering and analysis within both subsequent research projects. Alongside a description of how the data is currently being exploited and proposed future applications within the conservation and management of the site, it will finish by considering the impact of developing geospatial imaging technologies.

Land Application of Wastes: An Educational Program. Drainage for Land Application Sites - Module 21, Objectives, and Script.

ERIC Educational Resources Information Center

Clarkson, W. W.; And Others

Drainage for land treatment sites must be evaluated with respect to the purpose the system is meant to achieve. Off-site drainage controls the flow of storm runoff onto the site or groundwater incursion into the soil within the site. On-site drainage is employed for a variety of reasons. These two areas of drainage control must be designed as a…

New developments in measurements technology relevant to the studies of deep geological repositories in bedded salt

NASA Astrophysics Data System (ADS)

Mao, N. H.; Ramirez, A. L.

1980-10-01

Developments in measurement technology are presented which are relevant to the studies of deep geological repositories for nuclear waste disposal during all phases of development, i.e., site selection, site characterization, construction, operation, and decommission. Emphasis was placed on geophysics and geotechnics with special attention to those techniques applicable to bedded salt. The techniques are grouped into sections as follows: tectonic environment, state of stress, subsurface structures, fractures, stress changes, deformation, thermal properties, fluid transport properties, and other approaches. Several areas that merit further research and developments are identified. These areas are: in situ thermal measurement techniques, fracture detection and characterization, in situ stress measurements, and creep behavior. The available instrumentations should generally be improved to have better resolution and accuracy, enhanced instrument survivability, and reliability for extended time periods in a hostile environment.

Introduction and a Quick Look at MUESR, the Magnetic Structure and mUon Embedding Site Refinement Suite

NASA Astrophysics Data System (ADS)

Bonfà, Pietro; Onuorah, Ifeanyi John; De Renzi, Roberto

The estimation of the magnetic field generated at a given point by magnetic dipoles is an undergraduate exercise. However, under certain approximation, this is all that is needed to evaluate the local field at the muon site once the interstitial position of the muon in the unit cell is known. The development of an application to specifically solve this problem may therefore seem an excessive effort. At the same time, the lack of a general solution leads to the development of small ad hoc codes that are generally rewritten or re-adapted for different experiments and are poorly optimized. This and other motivations led to the development of MuESR, a python+C tool to perform dipolar field simulations. In this manuscript we will describe the tool, its features and its development strategies.

Idaho National Laboratory (INL) Site Greenhouse Gas (GHG) Monitoring Plan - 40 CFR 98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deborah L. Layton; Kimberly Frerichs

2011-12-01

The purpose of this Greenhouse Gas (GHG) Monitoring Plan is to meet the monitoring plan requirements of Title 40 of the Code of Federal Regulations Part 98.3(g)(5). This GHG Monitoring Plan identifies procedures and methodologies used at the Idaho National Laboratory Site (INL Site) to collect data used for GHG emissions calculations and reporting requirements from stationary combustion and other regulated sources in accordance with 40 CFR 98, Subparts A and other applicable subparts. INL Site Contractors determined subpart applicability through the use of a checklist (Appendix A). Each facility/contractor reviews operations to determine which subparts are applicable and themore » results are compiled to determine which subparts are applicable to the INL Site. This plan is applicable to the 40 CFR 98-regulated activities managed by the INL Site contractors: Idaho National Laboratory (INL), Idaho Cleanup Project (ICP), Advanced Mixed Waste Treatment Project (AMWTP), and Naval Reactors Facilities (NRF).« less

Idaho National Laboratory (INL) Site Greenhouse Gas (GHG) Monitoring Plan - 40 CFR 98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deborah L. Layton; Kimberly Frerichs

2010-07-01

The purpose of this Greenhouse Gas (GHG) Monitoring Plan is to meet the monitoring plan requirements of Title 40 of the Code of Federal Regulations Part 98.3(g)(5). This GHG Monitoring Plan identifies procedures and methodologies used at the Idaho National Laboratory Site (INL Site) to collect data used for GHG emissions calculations and reporting requirements from stationary combustion and other regulated sources in accordance with 40 CFR 98, Subparts A and other applicable subparts. INL Site Contractors determined subpart applicability through the use of a checklist (Appendix A). Each facility/contractor reviews operations to determine which subparts are applicable and themore » results are compiled to determine which subparts are applicable to the INL Site. This plan is applicable to the 40 CFR 98-regulated activities managed by the INL Site contractors: Idaho National Laboratory (INL), Idaho Cleanup Project (ICP), Advanced Mixed Waste Treatment Project (AMWTP), and Naval Reactors Facilities (NRF).« less

Effect of application timing on efficacy of site preparation treatments using Chopper® GEN2™

Treesearch

A.W. Ezell; J.L. Yeiser; D.K. Lauer; H.E. Quicke

2013-01-01

Chopper® GEN2™ is a new imazapyr product for use in forestry site preparation. A single treatment (32 ounces of Chopper® GEN2™ per acre) was applied at three timings on three sites (Louisiana, Mississippi, and Virginia) to test the effect of application timing on treatment efficacy. Hardwood control was excellent for all applications. Pine growth varied by site, but...

An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.

PubMed

Bland, Michael J; Ducos-Galand, Magaly; Val, Marie-Eve; Mazel, Didier

2017-07-14

Direct manipulation of the genome is a widespread technique for genetic studies and synthetic biology applications. The tyrosine and serine site-specific recombination systems of bacteriophages HK022 and ΦC31 are widely used for stable directional exchange and relocation of DNA sequences, making them valuable tools in these contexts. We have developed site-specific recombination tools that allow the direct selection of recombination events by embedding the attB site from each system within the β-lactamase resistance coding sequence (bla). The HK and ΦC31 tools were developed by placing the attB sites from each system into the signal peptide cleavage site coding sequence of bla. All possible open reading frames (ORFs) were inserted and tested for recombination efficiency and bla activity. Efficient recombination was observed for all tested ORFs (3 for HK, 6 for ΦC31) as shown through a cointegrate formation assay. The bla gene with the embedded attB site was functional for eight of the nine constructs tested. The HK/ΦC31 att-bla system offers a simple way to directly select recombination events, thus enhancing the use of site-specific recombination systems for carrying out precise, large-scale DNA manipulation, and adding useful tools to the genetics toolbox. We further show the power and flexibility of bla to be used as a reporter for recombination.

Best Practices for Environmental Site Management: A Practical Guide for Applying Environmental Sequence Stratigraphy to Improve Conceptual Site Models

EPA Science Inventory

Presented here is a practical guide on the application of the geologic principles of sequence stratigraphy and facies models to the characterization of stratigraphic heterogeneity at hazardous waste sites. This technology is applicable to sites underlain by clastic aquifers (int...

Quality, range, and legibility in web sites related to orofacial functions.

PubMed

Corrêa, Camila de Castro; Ferrari, Deborah Viviane; Berretin-Felix, Giédre

2013-10-01

Introduction Plenty of information about health is available on the Internet; however, quality and legibility are not always evaluated. Knowledge regarding orofacial functions can be considered important for the population because it allows proper stimulus, early diagnosis, and prevention of the oral myofunctional alterations during early infancy. Objective The aim was evaluate the quality, legibility, and range of Web sites available in Brazilian Portuguese regarding the orofacial functions. Methods Selected Web sites with information directed to parents/caregivers of babies regarding breast-feeding, feeding after 6 months, deleterious oral habits, and breathing and speech were studied. The Web sites were evaluated through the application of Flesch Reading Ease Test and aspects of the Health on the Net (HON) modified code (HONCode); the range of the subjects addressed was compared with other aspects of infant development. Results From the access of 350 pages of the Internet, 35 Web sites were selected and 315 excluded because they did not meet the inclusion criteria. In relation to legibility, Web sites scored an average of 61.23% in the Flesch Test, and the application of the modified HONCode showed an average of 6.43 points; an average of 2.49 subjects were found per Web site evaluated, with information on breast-feeding being more frequent and subjects such as breathing and speech less frequent. Conclusions Web sites that deal with orofacial functions presented standard legibility classification. Only half of the ethical principles were considered by the modified HONCode in their majority, and most addressed subjects after "breast-feeding" were presented with restricted range.

Quality, Range, and Legibility in Web Sites Related to Orofacial Functions

PubMed Central

Corrêa, Camila de Castro; Ferrari, Deborah Viviane; Berretin-Felix, Giédre

2013-01-01

Introduction Plenty of information about health is available on the Internet; however, quality and legibility are not always evaluated. Knowledge regarding orofacial functions can be considered important for the population because it allows proper stimulus, early diagnosis, and prevention of the oral myofunctional alterations during early infancy. Objective The aim was evaluate the quality, legibility, and range of Web sites available in Brazilian Portuguese regarding the orofacial functions. Methods Selected Web sites with information directed to parents/caregivers of babies regarding breast-feeding, feeding after 6 months, deleterious oral habits, and breathing and speech were studied. The Web sites were evaluated through the application of Flesch Reading Ease Test and aspects of the Health on the Net (HON) modified code (HONCode); the range of the subjects addressed was compared with other aspects of infant development. Results From the access of 350 pages of the Internet, 35 Web sites were selected and 315 excluded because they did not meet the inclusion criteria. In relation to legibility, Web sites scored an average of 61.23% in the Flesch Test, and the application of the modified HONCode showed an average of 6.43 points; an average of 2.49 subjects were found per Web site evaluated, with information on breast-feeding being more frequent and subjects such as breathing and speech less frequent. Conclusions Web sites that deal with orofacial functions presented standard legibility classification. Only half of the ethical principles were considered by the modified HONCode in their majority, and most addressed subjects after “breast-feeding” were presented with restricted range. PMID:25992036

Corral Monitoring System assessment results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Filby, E.E.; Haskel, K.J.

1998-03-01

This report describes the results of a functional and operational assessment of the Corral Monitoring Systems (CMS), which was designed to detect and document accountable items entering or leaving a monitored site. Its development was motivated by the possibility that multiple sites in the nuclear weapons states of the former Soviet Union might be opened to such monitoring under the provisions of the Strategic Arms Reduction Treaty. The assessment was performed at three levels. One level evaluated how well the planned approach addressed the target application, and which involved tracking sensitive items moving into and around a site being monitoredmore » as part of an international treaty or other agreement. The second level examined the overall design and development approach, while the third focused on individual subsystems within the total package. Unfortunately, the system was delivered as disassembled parts and pieces, with very poor documentation. Thus, the assessment was based on fragmentary operating data coupled with an analysis of what documents were provided with the system. The system design seemed to be a reasonable match to the requirements of the target application; however, important questions about site manning and top level administrative control were left unanswered. Four weaknesses in the overall design and development approach were detected: (1) poor configuration control and management, (2) inadequate adherence to a well defined architectural standard, (3) no apparent provision for improving top level error tolerance, and (4) weaknesses in the object oriented programming approach. The individual subsystems were found to offer few features or capabilities that were new or unique, even at the conceptual level. The CMS might possibly have offered a unique combination of features, but this level of integration was never realized, and it had no unique capabilities that could be readily extracted for use in another system.« less

The Environmental Protection Agency's Safety Standards for Disposal of Spent Nuclear Fuel: Potential Path Forward in Response to the Report of the Blue Ribbon Commission on America's Nuclear Future - 13388

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forinash, Betsy; Schultheisz, Daniel; Peake, Tom

2013-07-01

Following the decision to withdraw the Yucca Mountain license application, the Department of Energy created a Blue Ribbon Commission (BRC) on America's Nuclear Future, tasked with recommending a national strategy to manage the back end of the nuclear fuel cycle. The BRC issued its final report in January 2012, with recommendations covering transportation, storage and disposal of spent nuclear fuel (SNF); potential reprocessing; and supporting institutional measures. The BRC recommendations on disposal of SNF and high-level waste (HLW) are relevant to the U.S. Environmental Protection Agency (EPA), which shares regulatory responsibility with the Nuclear Regulatory Commission (NRC): EPA issues 'generallymore » applicable' performance standards for disposal repositories, which are then implemented in licensing. For disposal, the BRC endorses developing one or more geological repositories, with siting based on an approach that is adaptive, staged and consent-based. The BRC recommends that EPA and NRC work cooperatively to issue generic disposal standards-applying equally to all sites-early in any siting process. EPA previously issued generic disposal standards that apply to all sites other than Yucca Mountain. However, the BRC concluded that the existing regulations should be revisited and revised. The BRC proposes a number of general principles to guide the development of future regulations. EPA continues to review the BRC report and to assess the implications for Agency action, including potential regulatory issues and considerations if EPA develops new or revised generic disposal standards. This review also involves preparatory activities to define potential process and public engagement approaches. (authors)« less

Innovative vitrification for soil remediation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jetta, N.W.; Patten, J.S.; Hart, J.G.

1995-12-01

The objective of this DOE demonstration program is to validate the performance and operation of the Vortec Cyclone Melting System (CMS{trademark}) for the processing of LLW contaminated soils found at DOE sites. This DOE vitrification demonstration project has successfully progressed through the first two phases. Phase 1 consisted of pilot scale testing with surrogate wastes and the conceptual design of a process plant operating at a generic DOE site. The objective of Phase 2, which is scheduled to be completed the end of FY 95, is to develop a definitive process plant design for the treatment of wastes at amore » specific DOE facility. During Phase 2, a site specific design was developed for the processing of LLW soils and muds containing TSCA organics and RCRA metal contaminants. Phase 3 will consist of a full scale demonstration at the DOE gaseous diffusion plant located in Paducah, KY. Several DOE sites were evaluated for potential application of the technology. Paducah was selected for the demonstration program because of their urgent waste remediation needs as well as their strong management and cost sharing financial support for the project. During Phase 2, the basic nitrification process design was modified to meet the specific needs of the new waste streams available at Paducah. The system design developed for Paducah has significantly enhanced the processing capabilities of the Vortec vitrification process. The overall system design now includes the capability to shred entire drums and drum packs containing mud, concrete, plastics and PCB`s as well as bulk waste materials. This enhanced processing capability will substantially expand the total DOE waste remediation applications of the technology.« less

Sediment quality criteria: A review with recommendations for developing criteria for the Hanford Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Driver, C.J.

1994-05-01

Criteria for determining the quality of liver sediment are necessary to ensure that concentrations of contaminants in aquatic systems are within acceptable limits for the protection of aquatic and human life. Such criteria should facilitate decision-making about remediation, handling, and disposal of contaminants. Several approaches to the development of sediment quality criteria (SQC) have been described and include both descriptive and numerical methods. However, no single method measures all impacts at all times to all organisms (U.S. EPA 1992b). The U.S. EPA`s interest is primarily in establishing chemically based, numerical SQC that are applicable nation-wide (Shea 1988). Of the approachesmore » proposed for SQC development, only three are being considered for numerical SQC on a national level. These approaches include an Equilibrium Partitioning Approach, a site-specific method using bioassays (the Apparent Effects Threshold Approach), and an approach similar to EPA`s water quality criteria (Pavlou and Weston 1984). Although national (or even regional) criteria address a number of political, litigative, and engineering needs, some researchers feel that protection of benthic communities require site-specific, biologically based criteria (Baudo et al. 1990). This is particularly true for areas where complex mixtures of contaminants are present in sediments. Other scientifically valid and accepted procedures for freshwater SQC include a background concentration approach, methods using field or spiked bioassays, a screening level concentration approach, the Apparent Effects Threshold Approach, the Sediment Quality Triad, the International Joint Commission Sediment Assessment Strategy, and the National Status and Trends Program Approach. The various sediment assessment approaches are evaluated for application to the Hanford Reach and recommendations for Hanford Site sediment quality criteria are discussed.« less

Marshall Space Flight Center Telescience Resource Kit

NASA Technical Reports Server (NTRS)

Wade, Gina

2016-01-01

Telescience Resource Kit (TReK) is a suite of software applications that can be used to monitor and control assets in space or on the ground. The Telescience Resource Kit was originally developed for the International Space Station program. Since then it has been used to support a variety of NASA programs and projects including the WB-57 Ascent Vehicle Experiment (WAVE) project, the Fast Affordable Science and Technology Satellite (FASTSAT) project, and the Constellation Program. The Payloads Operations Center (POC), also known as the Payload Operations Integration Center (POIC), provides the capability for payload users to operate their payloads at their home sites. In this environment, TReK provides local ground support system services and an interface to utilize remote services provided by the POC. TReK provides ground system services for local and remote payload user sites including International Partner sites, Telescience Support Centers, and U.S. Investigator sites in over 40 locations worldwide. General Capabilities: Support for various data interfaces such as User Datagram Protocol, Transmission Control Protocol, and Serial interfaces. Data Services - retrieve, process, record, playback, forward, and display data (ground based data or telemetry data). Command - create, modify, send, and track commands. Command Management - Configure one TReK system to serve as a command server/filter for other TReK systems. Database - databases are used to store telemetry and command definition information. Application Programming Interface (API) - ANSI C interface compatible with commercial products such as Visual C++, Visual Basic, LabVIEW, Borland C++, etc. The TReK API provides a bridge for users to develop software to access and extend TReK services. Environments - development, test, simulations, training, and flight. Includes standalone training simulators.

24 CFR 242.78 - Zoning, deed, and building restrictions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Zoning, deed, and building... AUTHORITIES MORTGAGE INSURANCE FOR HOSPITALS Miscellaneous Requirements § 242.78 Zoning, deed, and building... to the project site, and shall comply with all applicable building and other governmental codes...

Applications of remote-sensing technology to environmental problems of Delaware and Delaware Bay

NASA Technical Reports Server (NTRS)

Bartlett, D.; Klemas, V.; Philpot, W.; Rogers, R.

1975-01-01

Digital processing of multispectral LANDSAT data was used to develop a computerized model for predicting oil slick movement within the Delaware Bay. LANDSAT imagery was also used to monitor offshore waste disposal sites for mapping of wetlands, and charting of tidal currents.

[Ion mobility spectrometer (IMS): a novel online monitor of trace volatile organic compounds].

PubMed

Li, Fang; Xie, Zhi-yong; Schmidt, H; Sielemann, S; Baumbach, J I

2002-12-01

The principle, character and developments of the instrument of ion mobility spectrometry are introduced, the applications of IMS to chemical warfare agents, explosives, drugs, environments monitoring and on-site industrial sensing are discussed, and some work on IMS in ISAS is represented.

75 FR 12730 - Foreign-Trade Zone 163-Ponce, Puerto Rico; Application for Expansion

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

..., Puerto Rico; Application for Expansion An application has been submitted to the Foreign-Trade Zones (FTZ... include an additional site in the Ponce, Puerto Rico area, within the Ponce Customs and Border Protection.../15/09). The zone project currently consists of the following sites in Puerto Rico: Site 1 (106 acres...

Effect of application site, clothing barrier, and application site washing on testosterone transfer with a 1.62% testosterone gel.

PubMed

Stahlman, Jodi; Britto, Margaret; Fitzpatrick, Sherahe; McWhirter, Cecilia; Testino, Samuel A; Brennan, John J; Zumbrunnen, Troy L

2012-02-01

To evaluate the effect of application site location, clothing barrier, and application site washing on testosterone transfer from males dosed with 1.62% testosterone gel to female partners. Open-label, randomized, parallel group, crossover study performed in 24 healthy male/female couples. 2.5 or 5.0 g of gel was applied to upper arms and shoulders or abdomens of male subjects. Skin contact occurred 2 hours after gel application between male and female subjects to compare the effect of wearing or not wearing a t-shirt, washing or not washing before contact, and the effect of differing application sites. Treatments were separated by a 1-week washout period. On each dosing day, 15 minutes of supervised skin contact occurred between the dosed male and female partner. Contact was either abdomen to abdomen (male to female), or upper arms/shoulders (male) to upper arms/shoulders, wrists and hands (female), depending on the male application site. Serum samples were collected from females at baseline and after contact to assess secondary testosterone exposure. C(max) (maximum serum concentration), AUC(0-24) (area under serum concentration-time curve from 0-24 hours), and C(av) (time-averaged concentration over 24-hour post-contact period) were assessed. Subjects were monitored for adverse events. Testosterone exposure (C(av) and C(max)) in females increased by up to 27% (2.5 g) or up to 280% (5.0 g) from baseline after direct skin contact at 2 hours after gel application, although C(av) remained within the female eugonadal range. Transfer from the abdomen was prevented when a t-shirt was worn (2.5-g dose). When the application site was washed before contact, mean C(av) was comparable to baseline, and C(max) was slightly higher (14%). Transfer was higher after direct skin-to-skin contact when the application and contact sites were upper arms/shoulders versus the abdomen. Testosterone concentrations returned to baseline within 48 hours after last skin contact. There is a risk of testosterone transfer from males using 1.62% testosterone gel to others who come into direct skin contact with the application site. This can be prevented by covering the application site with a t-shirt (2.5-g dose), or washing the application site before contact. Women for these studies were not selected by menopausal status. The study was conducted under circumstances that were intended to simulate exaggerated conditions of contact and may not represent average contact under normal conditions. CLINICAL TRIAL REGISTRATION NCT NUMBERS: Study was not registered (first subject enrolled 28 November 2007).

CEO Sites Mission Management System (SMMS)

NASA Technical Reports Server (NTRS)

Trenchard, Mike

2014-01-01

Late in fiscal year 2011, the Crew Earth Observations (CEO) team was tasked to upgrade its science site database management tool, which at the time was integrated with the Automated Mission Planning System (AMPS) originally developed for Earth Observations mission planning in the 1980s. Although AMPS had been adapted and was reliably used by CEO for International Space Station (ISS) payload operations support, the database structure was dated, and the compiler required for modifications would not be supported in the Windows 7 64-bit operating system scheduled for implementation the following year. The Sites Mission Management System (SMMS) is now the tool used by CEO to manage a heritage Structured Query Language (SQL) database of more than 2,000 records for Earth science sites. SMMS is a carefully designed and crafted in-house software package with complete and detailed help files available for the user and meticulous internal documentation for future modifications. It was delivered in February 2012 for test and evaluation. Following acceptance, it was implemented for CEO mission operations support in April 2012. The database spans the period from the earliest systematic requests for astronaut photography during the shuttle era to current ISS mission support of the CEO science payload. Besides logging basic image information (site names, locations, broad application categories, and mission requests), the upgraded database management tool now tracks dates of creation, modification, and activation; imagery acquired in response to requests; the status and location of ancillary site information; and affiliations with studies, their sponsors, and collaborators. SMMS was designed to facilitate overall mission planning in terms of site selection and activation and provide the necessary site parameters for the Satellite Tool Kit (STK) Integrated Message Production List Editor (SIMPLE), which is used by CEO operations to perform daily ISS mission planning. The CEO team uses the SMMS for three general functions - database queries of content and status, individual site creation and updates, and mission planning. The CEO administrator of the science site database is able to create or modify the content of sites and activate or deactivate them based on the requirements of the sponsors. The administrator supports and implements ISS mission planning by assembling, reporting, and activating mission-specific site selections for management; deactivating sites as requirements are met; and creating new sites, such as International Charter sites for disasters, as circumstances warrant. In addition to the above CEO internal uses, when site planning for a specific ISS mission is complete and approved, the SMMS can produce and export those essential site database elements for the mission into XML format for use by onboard Earth-location systems, such as Worldmap. The design, development, and implementation of the SMMS resulted in a superior database management system for CEO science sites by focusing on the functions and applications of the database alone instead of integrating the database with the multipurpose configuration of the AMPS. Unlike the AMPS, it can function and be modified within the existing Windows 7 environment. The functions and applications of the SMMS were expanded to accommodate more database elements, report products, and a streamlined interface for data entry and review. A particularly elegant enhancement in data entry was the integration of the Google Earth application for the visual display and definition of site coordinates for site areas defined by multiple coordinates. Transfer between the SMMS and Google Earth is accomplished with a Keyhole Markup Language (KML) expression of geographic data (see figures 3 and 4). Site coordinates may be entered into the SMMS panel directly for display in Google Earth, or the coordinates may be defined on the Google Earth display as a mouse-controlled polygonal definition and transferred back into the SMMS as KML input. This significantly reduces the possibility of errors in coordinate entries and provides visualization of the scale of the site being defined. CEO now has a powerful tool for managing and defining sites on the Earth's surface for both targets of astronaut photography or other onboard remote sensing systems. It can also record and track results by sponsor, collaborator, or type of study.

7 CFR 1776.8 - Methods for submitting applications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... applications may be filed through Grants.gov, the official Federal Government Web site at http://www.grants.gov. The applicant must be registered with Grants.gov before they can submit a grant applicant. The applicant should refer to instructions found on the Grants.gov Web site for procedures for registering and...

7 CFR 1776.8 - Methods for submitting applications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... applications may be filed through Grants.gov, the official Federal Government Web site at http://www.grants.gov. The applicant must be registered with Grants.gov before they can submit a grant applicant. The applicant should refer to instructions found on the Grants.gov Web site for procedures for registering and...

7 CFR 1776.8 - Methods for submitting applications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... applications may be filed through Grants.gov, the official Federal Government Web site at http://www.grants.gov. The applicant must be registered with Grants.gov before they can submit a grant applicant. The applicant should refer to instructions found on the Grants.gov Web site for procedures for registering and...

7 CFR 1776.8 - Methods for submitting applications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... applications may be filed through Grants.gov, the official Federal Government Web site at http://www.grants.gov. The applicant must be registered with Grants.gov before they can submit a grant applicant. The applicant should refer to instructions found on the Grants.gov Web site for procedures for registering and...

7 CFR 1776.8 - Methods for submitting applications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... applications may be filed through Grants.gov, the official Federal Government Web site at http://www.grants.gov. The applicant must be registered with Grants.gov before they can submit a grant applicant. The applicant should refer to instructions found on the Grants.gov Web site for procedures for registering and...

Treatment Prevents Corrosion in Steel and Concrete Structures

NASA Technical Reports Server (NTRS)

2007-01-01

In the mid-1990s, to protect rebar from corrosion, NASA developed an electromigration technique that sends corrosion-inhibiting ions into rebar to prevent rust, corrosion, and separation from the surrounding concrete. Kennedy Space Center worked with Surtreat Holding LLC, of Pittsburgh, Pennsylvania, a company that had developed a chemical option to fight structural corrosion, combining Surtreat's TPS-II anti-corrosive solution and electromigration. Kennedy's materials scientists reviewed the applicability of the chemical treatment to the electromigration process and determined that it was an effective and environmentally friendly match. Ten years later, NASA is still using this approach to fight concrete corrosion, and it has also developed a new technology that will further advance these efforts-a liquid galvanic coating applied to the outer surface of reinforced concrete to protect the embedded rebar from corrosion. Surtreat licensed this new coating technology and put it to use at the U.S. Army Naha Port, in Okinawa, Japan. The new coating prevents corrosion of steel in concrete in several applications, including highway and bridge infrastructures, piers and docks, concrete balconies and ceilings, parking garages, cooling towers, and pipelines. A natural compliment to the new coating, Surtreat's Total Performance System provides diagnostic testing and site analysis to identify the scope of problems for each project, manufactures and prescribes site-specific solutions, controls material application, and verifies performance through follow-up testing and analysis.

40 CFR 221.5 - Processing fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... be charged in connection with each application for a permit for dumping in an existing dump site... with each application for a permit for dumping in a dump site other than a dump site designated in this...

40 CFR 221.5 - Processing fees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... be charged in connection with each application for a permit for dumping in an existing dump site... with each application for a permit for dumping in a dump site other than a dump site designated in this...

Strategies for detection of floodplain inundation with multi-frequency polarimetric SAR

NASA Technical Reports Server (NTRS)

Hess, Laura L.; Melack, John M.

1992-01-01

Mapping of floodplain inundation patterns is a key element in developing hydrological and biogeochemical models for large tropical river basins such as the Amazon. Knowledge of the time sequence of inundation is necessary to determine both water routing and biogenic gas fluxes. Synthetic Aperture Radar (SAR) is uniquely suited for this application because of its ability to penetrate cloud cover and, in many cases, to detect flooding beneath a forest or herbaceous canopy. A procedure for discriminating flooded forest, flooded herbaceous vegetation, and open water from other cover types for a coastal wetland site on the lower Altamaha floodplain, Georgia, emphasizing robust classifiers that are not site-specific is currently being developed.

Expanding rural primary care training by employing information technologies: the need for participation by medical reference librarians.

PubMed

Coggan, J M; Crandall, L A

1995-01-01

The use of rural sites to train badly needed primary care providers requires access to sophisticated medical information not traditionally available outside of academic health centers. Medical reference librarians can play a key role in the development of primary care training sites in rural settings. Electronic information technologies, with proactive support from medical reference librarians, can provide current and detailed information without concern for distance from the health science center library. This paper discusses recent developments in technology, describes current challenges to the application of this technology in rural settings, and provides policy recommendations for medical reference librarians to enhance rural primary care training.

A study on the application of topic models to motif finding algorithms.

PubMed

Basha Gutierrez, Josep; Nakai, Kenta

2016-12-22

Topic models are statistical algorithms which try to discover the structure of a set of documents according to the abstract topics contained in them. Here we try to apply this approach to the discovery of the structure of the transcription factor binding sites (TFBS) contained in a set of biological sequences, which is a fundamental problem in molecular biology research for the understanding of transcriptional regulation. Here we present two methods that make use of topic models for motif finding. First, we developed an algorithm in which first a set of biological sequences are treated as text documents, and the k-mers contained in them as words, to then build a correlated topic model (CTM) and iteratively reduce its perplexity. We also used the perplexity measurement of CTMs to improve our previous algorithm based on a genetic algorithm and several statistical coefficients. The algorithms were tested with 56 data sets from four different species and compared to 14 other methods by the use of several coefficients both at nucleotide and site level. The results of our first approach showed a performance comparable to the other methods studied, especially at site level and in sensitivity scores, in which it scored better than any of the 14 existing tools. In the case of our previous algorithm, the new approach with the addition of the perplexity measurement clearly outperformed all of the other methods in sensitivity, both at nucleotide and site level, and in overall performance at site level. The statistics obtained show that the performance of a motif finding method based on the use of a CTM is satisfying enough to conclude that the application of topic models is a valid method for developing motif finding algorithms. Moreover, the addition of topic models to a previously developed method dramatically increased its performance, suggesting that this combined algorithm can be a useful tool to successfully predict motifs in different kinds of sets of DNA sequences.

Optimization of a Time-Lapse Gravity Network for Carbon Sequestration

NASA Astrophysics Data System (ADS)

Appriou, D.; Strickland, C. E.; Ruprecht Yonkofski, C. M.

2017-12-01

The objective of this study is to evaluate what could be a comprehensive and optimal state of the art gravity monitoring network that would meet the UIC class VI regulation and insure that 90% of the CO2 injected remain underground. Time-lapse gravity surveys have a long history of effective applications of monitoring temporal density changes in the subsurface. For decades, gravity measurements have been used for a wide range of applications. The interest of time-lapse gravity surveys for monitoring carbon sequestration sites started recently. The success of their deployment in such sites depends upon a combination of favorable conditions, such as the reservoir geometry, depth, thickness, density change over time induced by the CO2 injection and the location of the instrument. In most cases, the density changes induced by the CO2 plume in the subsurface are not detectable from the surface but the use of borehole gravimeters can provide excellent results. In the framework of the National Assessment and Risk Partnership (NRAP) funded by the Department of Energy, the evaluation of the effectiveness of the gravity monitoring of a CO2 storage site has been assessed using multiple synthetic scenarios implemented on a community model developed for the Kimberlina site (e.g., fault leakage scenarios, borehole leakage). The Kimberlina carbon sequestration project was a pilot project located in southern San Joaquin Valley, California, aimed to safely inject 250,000 t CO2/yr for four years. Although the project was cancelled in 2012, the site characterization efforts resulted in the development of a geologic model. In this study, we present the results of the time-lapse gravity monitoring applied on different multiphase flow and reactive transport models developed by Lawrence Berkeley National Laboratory (i.e., no leakage, permeable fault zone, wellbore leakage). Our monitoring approach considers an ideal network, consisting of multiple vertical and horizontal instrumented boreholes that could be used to track the CO2 plume and potential leaks. A preliminary cost estimate will also be provided.

Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9.

PubMed

Prykhozhij, Sergey V; Fuller, Charlotte; Steele, Shelby L; Veinotte, Chansey J; Razaghi, Babak; Robitaille, Johane M; McMaster, Christopher R; Shlien, Adam; Malkin, David; Berman, Jason N

2018-06-14

We have optimized point mutation knock-ins into zebrafish genomic sites using clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 reagents and single-stranded oligodeoxynucleotides. The efficiency of knock-ins was assessed by a novel application of allele-specific polymerase chain reaction and confirmed by high-throughput sequencing. Anti-sense asymmetric oligo design was found to be the most successful optimization strategy. However, cut site proximity to the mutation and phosphorothioate oligo modifications also greatly improved knock-in efficiency. A previously unrecognized risk of off-target trans knock-ins was identified that we obviated through the development of a workflow for correct knock-in detection. Together these strategies greatly facilitate the study of human genetic diseases in zebrafish, with additional applicability to enhance CRISPR-based approaches in other animal model systems.

Physical techniques for delivering microwave energy to tissues.

PubMed Central

Hand, J. W.

1982-01-01

Some of the physical aspects of delivering microwave energy to tissues have been discussed. Effective penetration of a few cm may be achieved with external applicators whilst small coaxial or cylindrical devices can induce localized heating in sites accessible to catheters or to direct invasion. To heat deep tissue sites in general, systems of greater complexity involving a number of applicators with particular phase relationships between them are required. The problems of thermometry in the presence of electromagnetic fields fall outside the scope of this article. Their solution, however, is no less important to the future of clinical hyperthermia than the development of heating techniques. Finally, it should be remembered that physiological parameters such as blood flow have appreciable effects in determining the efficacy of the physical techniques described above. PMID:6950781

Proceedings from the Workshop on Phytoremediation of Inorganic Contaminants

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. T. Brown; G. Matthern; A. Glenn

The Metals and Radionuclides Product Line of the US Department of Energy (DOE) Subsurface Contaminants Focus Area (SCFA) is responsible for the development of technologies and systems that reduce the risk and cost of remediation of radionuclide and hazardous metal contamination in soils and groundwater. The rapid and efficient remediation of these sites and the areas surrounding them represents a technological challenge. Phytoremediation, the use of living plants to cleanup contaminated soils, sediments, surface water and groundwater, is an emerging technology that may be applicable to the problem. The use of phytoremediation to cleanup organic contamination is widely accepted andmore » is being implemented at numerous sites. This workshop was held to initiate a discussion in the scientific community about whether phytoremediation is applicable to inorganic contaminants, such as metals and radionuclides, across the DOE complex. The Workshop on Phytoremediation of Inorganic Contaminants was held at Argonne National Laboratory from November 30 through December 2, 1999. The purpose of the workshop was to provide SCFA and the DOE Environmental Restoration Program with an understanding of the status of phytoremediation as a potential remediation technology for DOE sites. The workshop was expected to identify data gaps, technologies ready for demonstration and deployment, and to provide a set of recommendations for the further development of these technologies.« less

Use of Emerging Grid Computing Technologies for the Analysis of LIGO Data

NASA Astrophysics Data System (ADS)

Koranda, Scott

2004-03-01

The LIGO Scientific Collaboration (LSC) today faces the challenge of enabling analysis of terabytes of LIGO data by hundreds of scientists from institutions all around the world. To meet this challenge the LSC is developing tools, infrastructure, applications, and expertise leveraging Grid Computing technologies available today, and making available to LSC scientists compute resources at sites across the United States and Europe. We use digital credentials for strong and secure authentication and authorization to compute resources and data. Building on top of products from the Globus project for high-speed data transfer and information discovery we have created the Lightweight Data Replicator (LDR) to securely and robustly replicate data to resource sites. We have deployed at our computing sites the Virtual Data Toolkit (VDT) Server and Client packages, developed in collaboration with our partners in the GriPhyN and iVDGL projects, providing uniform access to distributed resources for users and their applications. Taken together these Grid Computing technologies and infrastructure have formed the LSC DataGrid--a coherent and uniform environment across two continents for the analysis of gravitational-wave detector data. Much work, however, remains in order to scale current analyses and recent lessons learned need to be integrated into the next generation of Grid middleware.

PISCES: A "Stepping Stone" to International Space Exploration and Development

NASA Technical Reports Server (NTRS)

Howell, Joe T.; Henley, Mark W.; Schowengerdt, Frank

2007-01-01

The Pacific International Space Center for Exploration Systems (PISCES) was initiated by the Japan/US Science, Technology and Space Application Programs (JUSTSAP) to advance research and education in space exploration technology and systems working closely with the State of Hawaii. Hawaii has a heritage with space exploration including the training of Apollo astronauts and testing of lunar rover systems in some of the most realistic terrestrial sites available. The high altitude dry environment with greater solar insolation, and the dry lunar regolith-like volcanic ash and cratered terrain make Hawaiian sites ideal to support, international space exploration technology development, demonstration, education and training. This paper will summarize development and roles of PISCES in lunar surface analogs, simulations, technology demonstrations, research and training for space exploration technology and systems.

Evaluation of hybrid inverters for strategic environmental research and development program applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginn, J.W.

1995-11-01

The photovoltaic systems test facility at Sandia National Laboratories is evaluating the performance of large hybrid power-processing centers (PPC`s). The primary customer for this work has been the Strategic Environmental Research and Development Program (SERDP) of the Department of Defense. One of the goals of SERDP is to develop power-processing hardware to be used in photovoltaic-hybrid power systems at remote military installations. Power for these installations is presently provided by engine-generators. Currently, hardware for twelve such sites is in various stages of procurement. The subject of this talk is testing of the PPC for the first SERDP system, a 300-kWmore » unit for Superior Valley, a US Navy site at China Lake, California.« less

2010 NCCA oligochaete trophic index results to inform benthic ...

EPA Pesticide Factsheets

Over 400 sites were sampled in the nearshore of the U.S. Great Lakes during the National Coastal Condition Assessment (NCCA) field survey in summer 2010. To assess benthic ecological condition, 393 PONARs were attempted, and collected macroinvertebrates were identified and enumerated. Biological condition at each site was classified as good, fair or poor using the Oligochaete Trophic Index (OTI). The Great Lakes coasts were then classified by calculating percent area within a condition class: good (20.3%), fair (11.6%), and poor (18.0%). Due to unsuccessful PONARs, unclassified oligochaetes or no oligochaetes captured, 50.1% of the sampled area was classified as missing. In order to help focus future discussion and development of a Great Lakes benthic index, OTI results were compared to other traditional biotic integrity indices. In addition, unclassified sites were examined to determine possible methods or metrics that could prevent missing data in a newly developed index. not applicable

Microfluidic array platform for simultaneous lipid bilayer membrane formation.

PubMed

Zagnoni, M; Sandison, M E; Morgan, H

2009-01-01

In recent years, protein array technologies have found widespread applications in proteomics. However, new methods for high-throughput analysis of protein-protein and protein-compound interactions are still required. In this paper, an array of lipid bilayer membranes formed within a microfluidic system with integrated electrodes is presented. The system is comprised of three layers that are clamped together, thus rendering the device cleanable and reusable. The device microfluidics enable the simultaneous formation of an array of lipid bilayers using a previously developed air-exposure technique, thereby avoiding the need to manually form individual bilayers. The Ag/AgCl electrodes allow for ion channel measurements, each of the sites being independently addressable. Typically, a 50% yield in simultaneous lipid bilayer formation over 12 sites was obtained and ion channel recordings have been acquired over multiple sites. This system has great potential for the development of an automatable platform of suspended lipid bilayer arrays.

Geostatistics and GIS: tools for characterizing environmental contamination.

PubMed

Henshaw, Shannon L; Curriero, Frank C; Shields, Timothy M; Glass, Gregory E; Strickland, Paul T; Breysse, Patrick N

2004-08-01

Geostatistics is a set of statistical techniques used in the analysis of georeferenced data that can be applied to environmental contamination and remediation studies. In this study, the 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) contamination at a Superfund site in western Maryland is evaluated. Concern about the site and its future clean up has triggered interest within the community because residential development surrounds the area. Spatial statistical methods, of which geostatistics is a subset, are becoming increasingly popular, in part due to the availability of geographic information system (GIS) software in a variety of application packages. In this article, the joint use of ArcGIS software and the R statistical computing environment are demonstrated as an approach for comprehensive geostatistical analyses. The spatial regression method, kriging, is used to provide predictions of DDE levels at unsampled locations both within the site and the surrounding areas where residential development is ongoing.

Application of an automated natural language processing (NLP) workflow to enable federated search of external biomedical content in drug discovery and development.

PubMed

McEntire, Robin; Szalkowski, Debbie; Butler, James; Kuo, Michelle S; Chang, Meiping; Chang, Man; Freeman, Darren; McQuay, Sarah; Patel, Jagruti; McGlashen, Michael; Cornell, Wendy D; Xu, Jinghai James

2016-05-01

External content sources such as MEDLINE(®), National Institutes of Health (NIH) grants and conference websites provide access to the latest breaking biomedical information, which can inform pharmaceutical and biotechnology company pipeline decisions. The value of the sites for industry, however, is limited by the use of the public internet, the limited synonyms, the rarity of batch searching capability and the disconnected nature of the sites. Fortunately, many sites now offer their content for download and we have developed an automated internal workflow that uses text mining and tailored ontologies for programmatic search and knowledge extraction. We believe such an efficient and secure approach provides a competitive advantage to companies needing access to the latest information for a range of use cases and complements manually curated commercial sources. Copyright © 2016. Published by Elsevier Ltd.

Site-controlled quantum dots fabricated using an atomic-force microscope assisted technique

PubMed Central

Usuki, T; Ohshima, T; Sakuma, Y; Kawabe, M; Okada, Y; Takemoto, K; Miyazawa, T; Hirose, S; Nakata, Y; Takatsu, M; Yokoyama, N

2006-01-01

An atomic-force microscope assisted technique is developed to control the position and size of self-assembled semiconductor quantum dots (QDs). Presently, the site precision is as good as ± 1.5 nm and the size fluctuation is within ± 5% with the minimum controllable lateral diameter of 20 nm. With the ability of producing tightly packed and differently sized QDs, sophisticated QD arrays can be controllably fabricated for the application in quantum computing. The optical quality of such site-controlled QDs is found comparable to some conventionally self-assembled semiconductor QDs. The single dot photoluminescence of site-controlled InAs/InP QDs is studied in detail, presenting the prospect to utilize them in quantum communication as precisely controlled single photon emitters working at telecommunication bands.

A site-specific slurry application technique on grassland and on arable crops.

PubMed

Schellberg, Jürgen; Lock, Reiner

2009-01-01

There is evidence that unequal slurry application on agricultural land contributes to N losses to the environment. Heterogeneity within fields demands adequate response by means of variable rate application. A technique is presented which allows site-specific application of slurry on grassland and arable land based on pre-defined application maps. The system contains a valve controlling flow rate by an on-board PC. During operation, flow rate is measured and scaled against set point values given in the application map together with the geographic position of the site. The systems worked sufficiently precise at a flow rate between 0 and 25 l s(-1) and an offset of actual slurry flow from set point values between 0.33 and 0.67 l s(-1). Long-term experimentation is required to test if site-specific application de facto reduces N surplus within fields and so significantly contributes to the unloading of N in agricultural areas.

Visible emission from bismuth-doped yttrium oxide thin films for lighting and display applications.

PubMed

Scarangella, Adriana; Fabbri, Filippo; Reitano, Riccardo; Rossi, Francesca; Priolo, Francesco; Miritello, Maria

2017-12-11

Due to the great development of light sources for several applications from displays to lighting, great efforts are devoted to find stable and efficient visible emitting materials. Moreover, the requirement of Si compatibility could enlarge the range of applications inside microelectronic chips. In this scenario, we have studied the emission properties of bismuth doped yttrium oxide thin films grown on crystalline silicon. Under optical pumping at room temperature a stable and strong visible luminescence has been observed. In particular, by the involvement of Bi ions in the two available lattice sites, the emission can be tuned from violet to green by changing the excitation wavelength. Moreover, under electron beam at low accelerating voltages (3 keV) a blue emission with high efficiency and excellent stability has been recorded. The color is generated by the involvement of Bi ions in both the lattice sites. These peculiarities make this material interesting as a luminescent medium for applications in light emitting devices and field emission displays by opening new perspectives for the realization of silicon-technology compatible light sources operating at room temperature.

Advances and applications of occupancy models

USGS Publications Warehouse

Bailey, Larissa; MacKenzie, Darry I.; Nichols, James D.

2013-01-01

Summary: The past decade has seen an explosion in the development and application of models aimed at estimating species occurrence and occupancy dynamics while accounting for possible non-detection or species misidentification. We discuss some recent occupancy estimation methods and the biological systems that motivated their development. Collectively, these models offer tremendous flexibility, but simultaneously place added demands on the investigator. Unlike many mark–recapture scenarios, investigators utilizing occupancy models have the ability, and responsibility, to define their sample units (i.e. sites), replicate sampling occasions, time period over which species occurrence is assumed to be static and even the criteria that constitute ‘detection’ of a target species. Subsequent biological inference and interpretation of model parameters depend on these definitions and the ability to meet model assumptions. We demonstrate the relevance of these definitions by highlighting applications from a single biological system (an amphibian–pathogen system) and discuss situations where the use of occupancy models has been criticized. Finally, we use these applications to suggest future research and model development.

Estimating selected low-flow frequency statistics and harmonic-mean flows for ungaged, unregulated streams in Indiana

USGS Publications Warehouse

Martin, Gary R.; Fowler, Kathleen K.; Arihood, Leslie D.

2016-09-06

Information on low-flow characteristics of streams is essential for the management of water resources. This report provides equations for estimating the 1-, 7-, and 30-day mean low flows for a recurrence interval of 10 years and the harmonic-mean flow at ungaged, unregulated stream sites in Indiana. These equations were developed using the low-flow statistics and basin characteristics for 108 continuous-record streamgages in Indiana with at least 10 years of daily mean streamflow data through the 2011 climate year (April 1 through March 31). The equations were developed in cooperation with the Indiana Department of Environmental Management.Regression techniques were used to develop the equations for estimating low-flow frequency statistics and the harmonic-mean flows on the basis of drainage-basin characteristics. A geographic information system was used to measure basin characteristics for selected streamgages. A final set of 25 basin characteristics measured at all the streamgages were evaluated to choose the best predictors of the low-flow statistics.Logistic-regression equations applicable statewide are presented for estimating the probability that selected low-flow frequency statistics equal zero. These equations use the explanatory variables total drainage area, average transmissivity of the full thickness of the unconsolidated deposits within 1,000 feet of the stream network, and latitude of the basin outlet. The percentage of the streamgage low-flow statistics correctly classified as zero or nonzero using the logistic-regression equations ranged from 86.1 to 88.9 percent.Generalized-least-squares regression equations applicable statewide for estimating nonzero low-flow frequency statistics use total drainage area, the average hydraulic conductivity of the top 70 feet of unconsolidated deposits, the slope of the basin, and the index of permeability and thickness of the Quaternary surficial sediments as explanatory variables. The average standard error of prediction of these regression equations ranges from 55.7 to 61.5 percent.Regional weighted-least-squares regression equations were developed for estimating the harmonic-mean flows by dividing the State into three low-flow regions. The Northern region uses total drainage area and the average transmissivity of the entire thickness of unconsolidated deposits as explanatory variables. The Central region uses total drainage area, the average hydraulic conductivity of the entire thickness of unconsolidated deposits, and the index of permeability and thickness of the Quaternary surficial sediments. The Southern region uses total drainage area and the percent of the basin covered by forest. The average standard error of prediction for these equations ranges from 39.3 to 66.7 percent.The regional regression equations are applicable only to stream sites with low flows unaffected by regulation and to stream sites with drainage basin characteristic values within specified limits. Caution is advised when applying the equations for basins with characteristics near the applicable limits and for basins with karst drainage features and for urbanized basins. Extrapolations near and beyond the applicable basin characteristic limits will have unknown errors that may be large. Equations are presented for use in estimating the 90-percent prediction interval of the low-flow statistics estimated by use of the regression equations at a given stream site.The regression equations are to be incorporated into the U.S. Geological Survey StreamStats Web-based application for Indiana. StreamStats allows users to select a stream site on a map and automatically measure the needed basin characteristics and compute the estimated low-flow statistics and associated prediction intervals.

Applicability of a bioelectronic cardiac monitoring system for the detection of biological effects of pollution in bioindicator species in the Gulf of Finland

NASA Astrophysics Data System (ADS)

Kholodkevich, Sergey V.; Kuznetsova, Tatiana V.; Sharov, Andrey N.; Kurakin, Anton S.; Lips, Urmas; Kolesova, Natalia; Lehtonen, Kari K.

2017-07-01

Field testing of an innovative technology based on a bioelectronic cardiac monitoring system was carried out in the Gulf of Finland (Baltic Sea). The study shows that the bioelectronic system is suitable for the selected bivalve mollusks Mytilus trossulus, Macoma balthica and Anodonta anatina. Specimens taken from reference sites demonstrated a heart rate recovery time of < 60 min after testing with changed salinity load, while those collected from sites characterized by high anthropogenic pressure demonstrated a prolonged recovery time of up to 110-360 min. These results make possible a discrimination of the study sites based on the assessment of physiological adaptive capacities of inhabiting species. In addition, the approach of measuring heart rate characteristics in M. balthica transplanted in cages to specific target areas was successfully used to evaluate the decline in the adaptive potential of mollusks exposed at polluted sites. Application of the novel system is a useful tool for the biomonitoring of freshwater and brackish water areas. Development of methodological basis for the testing of adaptive capacities (health) of key aquatic organisms provides new knowledge of biological effects of anthropogenic chemical stress in aquatic organisms.

Modeling job sites in real time to improve safety during equipment operation

NASA Astrophysics Data System (ADS)

Caldas, Carlos H.; Haas, Carl T.; Liapi, Katherine A.; Teizer, Jochen

2006-03-01

Real-time three-dimensional (3D) modeling of work zones has received an increasing interest to perform equipment operation faster, safer and more precisely. In addition, hazardous job site environment like they exist on construction sites ask for new devices which can rapidly and actively model static and dynamic objects. Flash LADAR (Laser Detection and Ranging) cameras are one of the recent technology developments which allow rapid spatial data acquisition of scenes. Algorithms that can process and interpret the output of such enabling technologies into threedimensional models have the potential to significantly improve work processes. One particular important application is modeling the location and path of objects in the trajectory of heavy construction equipment navigation. Detecting and mapping people, materials and equipment into a three-dimensional computer model allows analyzing the location, path, and can limit or restrict access to hazardous areas. This paper presents experiments and results of a real-time three-dimensional modeling technique to detect static and moving objects within the field of view of a high-frame update rate laser range scanning device. Applications related to heavy equipment operations on transportation and construction job sites are specified.

A PDA-based flexible telecommunication system for telemedicine applications.

PubMed

Nazeran, Homer; Setty, Sunil; Haltiwanger, Emily; Gonzalez, Virgilio

2004-01-01

Technology has been used to deliver health care at a distance for many years. Telemedicine is a rapidly growing area and recently there are studies devoted to prehospital care of patients in emergency cases. In this work we have developed a compact, reliable, and low cost PDA-based telecommunication device for telemedicine applications to transmit audio, still images, and vital signs from a remote site to a fixed station such as a clinic or a hospital in real time. This was achieved based on a client-server architecture. A Pocket PC, a miniature camera, and a hands-free microphone were used at the client site and a desktop computer running the Windows XP operating system was used as a server. The server was located at a fixed station. The system was implemented on TCP/IP and HTTP protocol. Field tests have shown that the system can reliably transmit still images, audio, and sample vital signs from a simulated remote site to a fixed station either via a wired or wireless network in real time. The Pocket PC was used at the client site because of its compact size, low cost and processing capabilities.

Survey of existing underground openings for in-situ experimental facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wollenberg, H.; Graf, A.; Strisower, B.

1981-07-01

In an earlier project, a literature search identified 60 underground openings in crystalline rock capable of providing access for an in-situ experimental facility to develop geochemical and hydrological techniques for evaluating sites for radioactive waste isolation. As part of the current project, discussions with state geologists, owners, and operators narrowed the original group to 14. Three additional sites in volcanic rock and one site in granite were also identified. Site visits and application of technical criteria, including the geologic and hydrologic settings and depth, extent of the rock unit, condition, and accessibility of underground workings, determined four primary candidate sites:more » the Helms Pumped Storage Project in grandiodorite of the Sierra Nevada, California; the Tungsten Queen Mine in Precambrian granodiorite of the North Carolina Piedmont; the Mount Hope Mine in Precambrian granite and gneiss of northern New Jersey; and the Minnamax Project in the Duluth gabbro complex of northern Minnesota.« less

77 FR 31307 - Foreign-Trade Zone 41-Milwaukee, WI; Application for Reorganization (Expansion of Service Area...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... limit for a general-purpose zone project. The application was submitted pursuant to the Foreign-Trade... temporary sites as ``usage-driven'' sites: Site 12 (113.4 acres)-- Sigma-Aldrich Corporation, 5485 County Road ``V'', Sheboygan Falls, Sheboygan County; and, Site 13 (15.1 acres)--Sigma-Aldrich Corporation...

A Cost Comparison of Alternative Approaches to Distance Education in Developing Countries

NASA Technical Reports Server (NTRS)

Ventre, Gerard G.; Kalu, Alex

1996-01-01

This paper presents a cost comparison of three approaches to two-way interactive distance learning systems for developing countries. Included are costs for distance learning hardware, terrestrial and satellite communication links, and designing instruction for two-way interactive courses. As part of this project, FSEC is developing a 30-hour course in photovoltaic system design that will be used in a variety of experiments using the Advanced Communications Technology Satellite (ACTS). A primary goal of the project is to develop an instructional design and delivery model that can be used for other education and training programs. Over two-thirds of the world photovoltaics market is in developing countries. One of the objectives of this NASA-sponsored project was to develop new and better energy education programs that take advantage of advances in telecommunications and computer technology. The combination of desktop video systems and the sharing of computer applications software is of special interest. Research is being performed to evaluate the effectiveness of some of these technologies as part of this project. The design of the distance learning origination and receive sites discussed in this paper were influenced by the educational community's growing interest in distance education. The following approach was used to develop comparative costs for delivering interactive distance education to developing countries: (1) Representative target locations for receive sites were chosen. The originating site was assumed to be Cocoa, Florida, where FSEC is located; (2) A range of course development costs were determined; (3) The cost of equipment for three alternative two-way interactive distance learning system configurations was determined or estimated. The types of system configurations ranged from a PC-based system that allows instructors to originate instruction from their office using desktop video and shared application software, to a high cost system that uses a electronic classroom; (4) A range of costs for both satellite and terrestrial communications was investigated; (5) The costs of equipment and operation of the alternative configurations for the origination and receive sites were determined; (6) A range of costs for several alternative delivery scenarios (i.e., a mix of live-interactive; asynchronous interactive;use of videotapes) was determined; and (7) A preferred delivery scenario, including cost estimate, was developed.

Heterogeneity measures in hydrological frequency analysis: review and new developments

NASA Astrophysics Data System (ADS)

Requena, Ana I.; Chebana, Fateh; Ouarda, Taha B. M. J.

2017-03-01

Some regional procedures to estimate hydrological quantiles at ungauged sites, such as the index-flood method, require the delineation of homogeneous regions as a basic step for their application. The homogeneity of these delineated regions is usually tested providing a yes/no decision. However, complementary measures that are able to quantify the degree of heterogeneity of a region are needed to compare regions, evaluate the impact of particular sites, and rank the performance of different delineating methods. Well-known existing heterogeneity measures are not well-defined for ranking regions, as they entail drawbacks such as assuming a given probability distribution, providing negative values and being affected by the region size. Therefore, a framework for defining and assessing desirable properties of a heterogeneity measure in the regional hydrological context is needed. In the present study, such a framework is proposed through a four-step procedure based on Monte Carlo simulations. Several heterogeneity measures, some of which commonly known and others which are derived from recent approaches or adapted from other fields, are presented and developed to be assessed. The assumption-free Gini index applied on the at-site L-variation coefficient (L-CV) over a region led to the best results. The measure of the percentage of sites for which the regional L-CV is outside the confidence interval of the at-site L-CV is also found to be relevant, as it leads to more stable results regardless of the regional L-CV value. An illustrative application is also presented for didactical purposes, through which the subjectivity of commonly used criteria to assess the performance of different delineation methods is underlined.

A Restoration Suitability Index Model for the Eastern Oyster (Crassostrea virginica) in the Mission-Aransas Estuary, TX, USA

PubMed Central

Beseres Pollack, Jennifer; Cleveland, Andrew; Palmer, Terence A.; Reisinger, Anthony S.; Montagna, Paul A.

2012-01-01

Oyster reefs are one of the most threatened marine habitats on earth, with habitat loss resulting from water quality degradation, coastal development, destructive fishing practices, overfishing, and storm impacts. For successful and sustainable oyster reef restoration efforts, it is necessary to choose sites that support long-term growth and survival of oysters. Selection of suitable sites is critically important as it can greatly influence mortality factors and may largely determine the ultimate success of the restoration project. The application of Geographic Information Systems (GIS) provides an effective methodology for identifying suitable sites for oyster reef restoration and removes much of the uncertainty involved in the sometimes trial and error selection process. This approach also provides an objective and quantitative tool for planning future oyster reef restoration efforts. The aim of this study was to develop a restoration suitability index model and reef quality index model to characterize locations based on their potential for successful reef restoration within the Mission-Aransas Estuary, Texas, USA. The restoration suitability index model focuses on salinity, temperature, turbidity, dissolved oxygen, and depth, while the reef quality index model focuses on abundance of live oysters, dead shell, and spat. Size-specific Perkinsus marinus infection levels were mapped to illustrate general disease trends. This application was effective in identifying suitable sites for oyster reef restoration, is flexible in its use, and provides a mechanism for considering alternative approaches. The end product is a practical decision-support tool that can be used by coastal resource managers to improve oyster restoration efforts. As oyster reef restoration activities continue at small and large-scales, site selection criteria are critical for assisting stakeholders and managers and for maximizing long-term sustainability of oyster resources. PMID:22792410

EGIS - An Environmental GIS Developed for NASA Field Center Applications

NASA Technical Reports Server (NTRS)

Smoot, James; Cohan, Tyrus; O'Connor, Christina; Johnson, Gary; Carr, Hugh

2001-01-01

As the principal center for Environmental Geographic Information Systems (EGIS), the John C. Stennis Space Center (SSC), located in Hancock County, Mississippi, has been assigned technical support requirements to design and to implement a basic EGIS data base for all NASA Field Centers. The intent of this Phase I effort is to produce a baseline EGIS data base incorporating newly available remotely sensed data as well as existing environmental data. A example application of the use of the data base at Stennis Space Center will be to illustrate baseline environmental conditions for consideration with proposed propulsion test stand development and operation. To effectively answer questions related to environmental issues at each center, organization of the data layers and sources will include the following categories: Cadastral/Geodetic; Geopolitical; Hydrography; Infrastructure; Physical Geography; Socioeconomic; Remote Sensing Imagery; Associated Metadata. As part of a Phase II effort, site-specific data and applications will be implemented and added to the data base at each Field Center. This poster illustrates the framework of the design and implementation of a basic EGIS data base. Shown are example data sources, hardware and software, and data base delivery and installation. The poster also depicts future recommendations for a centrally located server to house each of the NASA Field Center data bases. The server will allow real-time data base updates with additional layers and models for each center. Expansion of the EGIS data base will continue to grow as site-specific applications are developed addressing the ongoing evolution of environmental concerns at all NASA Field Centers.

10 CFR 2.623 - Notice of hearing on application for early review of site suitability issues in combined license...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Notice of hearing on application for early review of site... AGENCY RULES OF PRACTICE AND PROCEDURE Additional Procedures Applicable to Early Partial Decisions on... Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part 52 § 2.623 Notice of...

10 CFR 2.623 - Notice of hearing on application for early review of site suitability issues in combined license...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Notice of hearing on application for early review of site... AGENCY RULES OF PRACTICE AND PROCEDURE Additional Procedures Applicable to Early Partial Decisions on... Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part 52 § 2.623 Notice of...

Browser-Based Online Applications: Something for Everyone!

ERIC Educational Resources Information Center

Descy, Don E.

2007-01-01

Just as many people log onto a Web mail site (Gmail, Yahoo, MSN, etc.) to read, write and store their email, there are Web sites out there with word processing, database, and a myriad of other software applications that are not downloadable but used on the site through a Web browser. The user does not have to download the applications to a…

10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Pre-Application Early Review of Site Suitability Issues Q Appendix Q to Part 50 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This...

10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Pre-Application Early Review of Site Suitability Issues Q Appendix Q to Part 50 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This...

10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Pre-Application Early Review of Site Suitability Issues Q Appendix Q to Part 50 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This...

ptchg: A FORTRAN program for point-charge calculations of electric field gradients (EFGs)

NASA Astrophysics Data System (ADS)

Spearing, Dane R.

1994-05-01

ptchg, a FORTRAN program, has been developed to calculate electric field gradients (EFG) around an atomic site in crystalline solids using the point-charge direct-lattice summation method. It uses output from the crystal structure generation program Atoms as its input. As an application of ptchg, a point-charge calculation of the EFG quadrupolar parameters around the oxygen site in SiO 2 cristobalite is demonstrated. Although point-charge calculations of electric field gradients generally are limited to ionic compounds, the computed quadrupolar parameters around the oxygen site in SiO 2 cristobalite, a highly covalent material, are in good agreement with the experimentally determined values from nuclear magnetic resonance (NMR) spectroscopy.

Development and Potential Applications of CRISPR-Cas9 Genome Editing Technology in Sarcoma

PubMed Central

Liu, Tang; Shen, Jacson K.; Li, Zhihong; Choy, Edwin; Hornicek, Francis J.; Duan, Zhenfeng

2016-01-01

Sarcomas include some of the most aggressive tumors and typically respond poorly to chemotherapy. In recent years, specific gene fusion/mutations and gene over-expression/activation have been shown to drive sarcoma pathogenesis and development. These emerging genomic alterations may provide targets for novel therapeutic strategies and have the potential to transform sarcoma patient care. The RNA-guided nuclease CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein-9 nuclease) is a convenient and versatile platform for site-specific genome editing and epigenome targeted modulation. Given that sarcoma is believed to develop as a result of genetic alterations in mesenchymal progenitor/stem cells, CRISPR-Cas9 genome editing technologies hold extensive application potentials in sarcoma models and therapies. We review the development and mechanisms of the CRISPR-Cas9 system in genome editing and introduce its application in sarcoma research and potential therapy in clinic. Additionally, we propose future directions and discuss the challenges faced with these applications, providing concise and enlightening information for readers interested in this area. PMID:26806808

Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.

PubMed

Liu, Tang; Shen, Jacson K; Li, Zhihong; Choy, Edwin; Hornicek, Francis J; Duan, Zhenfeng

2016-04-01

Sarcomas include some of the most aggressive tumors and typically respond poorly to chemotherapy. In recent years, specific gene fusion/mutations and gene over-expression/activation have been shown to drive sarcoma pathogenesis and development. These emerging genomic alterations may provide targets for novel therapeutic strategies and have the potential to transform sarcoma patient care. The RNA-guided nuclease CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein-9 nuclease) is a convenient and versatile platform for site-specific genome editing and epigenome targeted modulation. Given that sarcoma is believed to develop as a result of genetic alterations in mesenchymal progenitor/stem cells, CRISPR-Cas9 genome editing technologies hold extensive application potentials in sarcoma models and therapies. We review the development and mechanisms of the CRISPR-Cas9 system in genome editing and introduce its application in sarcoma research and potential therapy in clinic. Additionally, we propose future directions and discuss the challenges faced with these applications, providing concise and enlightening information for readers interested in this area. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

24 CFR 200.73 - Property development.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... (a) The property shall be suitable and principally designed for the intended use, as provided by the applicable section of the Act under which the mortgage is insured, and have long-term marketability. Design... or personal care units, 20 medical care beds, or 50 manufactured home pads, shall be on one site...

APPLICATION OF SUSTAINABILITY CRITERIA TO STELLA, MISSOURI-ENVIRONMENTAL PLANNING-PRELIMINARY SITE INFORMATION AND ELEMENTS OF THE MASTER PLAN

EPA Science Inventory

Natural systems provide essential goods and services that make human life possible. Because development of the built environment will cumulatively consume natural capital, it is essential that the conditions that maintain natural systems must become the constraints and performanc...

APPLICATION OF A "VITURAL FIELD REFERENCE DATABASE" TO ASSESS LAND-COVER MAP ACCURACIES

EPA Science Inventory

An accuracy assessment was performed for the Neuse River Basin, NC land-cover/use
(LCLU) mapping results using a "Virtual Field Reference Database (VFRDB)". The VFRDB was developed using field measurement and digital imagery (camera) data collected at 1,409 sites over a perio...

Coordinating Technological Resources in a Non-Technical Profession: The Administrative Computer User Group.

ERIC Educational Resources Information Center

Rollo, J. Michael; Marmarchev, Helen L.

1999-01-01

The explosion of computer applications in the modern workplace has required student affairs professionals to keep pace with technological advances for office productivity. This article recommends establishing an administrative computer user groups, utilizing coordinated web site development, and enhancing working relationships as ways of dealing…

--No Title--

Science.gov Websites

You may be trying to access this site from a secured browser on the server. Please enable scripts and utilizing to make their lives easier and access to information literally at their fingertips. To make information readily available, U. S. Fleet Forces developed mobile applications to provide the

Natural Phenomena Hazards Design Criteria and Other Characterization Information for the MFFF at SRS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wyatt, D.E.

This report is a comprehensive complication applicable to the general Savannah River Site area, developed by both the original contractor, the DuPont Company, and by the current plant operator, Westinghouse Savannah River Company, over the full plant lifetime period (1950 - 2000).

EXPERIMENTAL EVALUATION OF TWO SHARP FRONT MODELS FOR VADOSE ZONE NON-AQUEOUS PHASE LIQUID TRANSPORT

EPA Science Inventory

Recent research efforts on the transport of immiscible organic wastes in subsurface the development of numerical models of various levels of sophistication. Systems have focused on the site characterization data needed to obtain. However, in real field applications, the model p...

Landscape Metrics Arranged by Hydrological Proximity to Sites on Mississippi, Missouri, and Ohio Rivers

EPA Science Inventory

This work has been published to demonstrate an application that the authors made of the geospatial National Hydrography Dataset (NHDPlus) that was developed by Horizon Systems Corporation for the US EPA. NHDPlus was produced to enhance hydrological maps of the United States for ...

10 CFR Appendix A to Subpart D of... - Categorical Exclusions Applicable to General Agency Actions

Code of Federal Regulations, 2012 CFR

2012-01-01

... agreements for energy research and development A1Routine DOE business actions Routine actions necessary to... dissemination Information gathering (including, but not limited to, literature surveys, inventories, site visits... (including, but not limited to, conceptual design, feasibility studies, and analytical energy supply and...

10 CFR Appendix A to Subpart D of... - Categorical Exclusions Applicable to General Agency Actions

Code of Federal Regulations, 2014 CFR

2014-01-01

... International agreements for energy research and development A1 Routine DOE business actions Routine actions... dissemination Information gathering (including, but not limited to, literature surveys, inventories, site visits... (including, but not limited to, conceptual design, feasibility studies, and analytical energy supply and...

10 CFR Appendix A to Subpart D of... - Categorical Exclusions Applicable to General Agency Actions

Code of Federal Regulations, 2013 CFR

2013-01-01

... agreements for energy research and development A1Routine DOE business actions Routine actions necessary to... dissemination Information gathering (including, but not limited to, literature surveys, inventories, site visits... (including, but not limited to, conceptual design, feasibility studies, and analytical energy supply and...

TTIP: Texas Teacher Internship Program 1994 Curriculum Implementation Plans.

ERIC Educational Resources Information Center

Walenta, Brian T., Ed.

The Texas Teacher Internship Program (TTIP) is a competitive program for science, technology and mathematics teachers who serve as summer interns at industry and university sites in order to experience real world applications of the subjects they teach. This document contains curriculum implementation plans developed by the teachers to illustrate…

The Use of Molecular and Genomic Techniques Applied to Microbial Diversity, Community Structure, and Activities at DNAPL and Metal Contaminated Sites

EPA Science Inventory

A wide variety of in situ subsurface remediation strategies have been developed to mitigate contamination by chlorinated solvent dense non-aqueous phase liquids (DNAPLS) and metals. Geochemical methods include: zerovalent iron emplacement, various electrolytic applications, elec...

Watershed regressions for pesticides (warp) models for predicting atrazine concentrations in Corn Belt streams

USGS Publications Warehouse

Stone, Wesley W.; Gilliom, Robert J.

2012-01-01

Watershed Regressions for Pesticides (WARP) models, previously developed for atrazine at the national scale, are improved for application to the United States (U.S.) Corn Belt region by developing region-specific models that include watershed characteristics that are influential in predicting atrazine concentration statistics within the Corn Belt. WARP models for the Corn Belt (WARP-CB) were developed for annual maximum moving-average (14-, 21-, 30-, 60-, and 90-day durations) and annual 95th-percentile atrazine concentrations in streams of the Corn Belt region. The WARP-CB models accounted for 53 to 62% of the variability in the various concentration statistics among the model-development sites. Model predictions were within a factor of 5 of the observed concentration statistic for over 90% of the model-development sites. The WARP-CB residuals and uncertainty are lower than those of the National WARP model for the same sites. Although atrazine-use intensity is the most important explanatory variable in the National WARP models, it is not a significant variable in the WARP-CB models. The WARP-CB models provide improved predictions for Corn Belt streams draining watersheds with atrazine-use intensities of 17 kg/km2 of watershed area or greater.

Dual benefit robotics programs at Sandia National Laboratories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, A.T.

Sandia National Laboratories has one of the largest integrated robotics laboratories in the United States. Projects include research, development, and application of one-of-a-kind systems, primarily for the Department of Energy (DOE) complex. This work has been underway for more than 10 years. It began with on-site activities that required remote operation, such as reactor and nuclear waste handling. Special purpose robot systems were developed using existing commercial manipulators and fixtures and programs designed in-house. These systems were used in applications such as servicing the Sandia pulsed reactor and inspecting remote roof bolts in an underground radioactive waste disposal facility. Inmore » the beginning, robotics was a small effort, but with increasing attention to the use of robots for hazardous operations, efforts now involve a staff of more than 100 people working in a broad robotics research, development, and applications program that has access to more than 30 robotics systems.« less

Improving ATLAS grid site reliability with functional tests using HammerCloud

NASA Astrophysics Data System (ADS)

Elmsheuser, Johannes; Legger, Federica; Medrano Llamas, Ramon; Sciacca, Gianfranco; van der Ster, Dan

2012-12-01

With the exponential growth of LHC (Large Hadron Collider) data in 2011, and more coming in 2012, distributed computing has become the established way to analyse collider data. The ATLAS grid infrastructure includes almost 100 sites worldwide, ranging from large national computing centers to smaller university clusters. These facilities are used for data reconstruction and simulation, which are centrally managed by the ATLAS production system, and for distributed user analysis. To ensure the smooth operation of such a complex system, regular tests of all sites are necessary to validate the site capability of successfully executing user and production jobs. We report on the development, optimization and results of an automated functional testing suite using the HammerCloud framework. Functional tests are short lightweight applications covering typical user analysis and production schemes, which are periodically submitted to all ATLAS grid sites. Results from those tests are collected and used to evaluate site performances. Sites that fail or are unable to run the tests are automatically excluded from the PanDA brokerage system, therefore avoiding user or production jobs to be sent to problematic sites.

U.S. Geological Survey science for the Wyoming Landscape Conservation Initiative—2014 annual report

USGS Publications Warehouse

Bowen, Zachary H.; Aldridge, Cameron L.; Anderson, Patrick J.; Assal, Timothy J.; Bartos, Timothy T.; Biewick, Laura R; Boughton, Gregory K.; Chalfoun, Anna D.; Chong, Geneva W.; Dematatis, Marie K.; Eddy-Miller, Cheryl A.; Garman, Steven L.; Germaine, Stephen S.; Homer, Collin G.; Huber, Christopher; Kauffman, Matthew J.; Latysh, Natalie; Manier, Daniel; Melcher, Cynthia P.; Miller, Alexander; Miller, Kirk A.; Olexa, Edward M.; Schell, Spencer; Walters, Annika W.; Wilson, Anna B.; Wyckoff, Teal B.

2015-01-01

Finally, capabilities of the WLCI Web site and the USGS ScienceBase infrastructure were maintained and upgraded to help ensure access to and efficient use of all the WLCI data, products, assessment tools, and outreach materials that have been developed. Of particular note is the completion of three Web applications developed for mapping (1) the 1900−2008 progression of oil and gas development;(2) the predicted distributions of Wyoming’s Species of Greatest Conservation Need; and (3) the locations of coal and wind energy production, sage-grouse distribution and core management areas, and alternative routes for transmission lines within the WLCI region. Collectively, these applications tools provide WLCI planners and managers with powerful tools for better understanding the distributions of wildlife species and potential alternatives for energy development.

Working Up a Good Sweat – The Challenges of Standardising Sweat Collection for Metabolomics Analysis

PubMed Central

Hussain, Joy N; Mantri, Nitin; Cohen, Marc M

2017-01-01

Introduction Human sweat is a complex biofluid of interest to diverse scientific fields. Metabolomics analysis of sweat promises to improve screening, diagnosis and self-monitoring of numerous conditions through new applications and greater personalisation of medical interventions. Before these applications can be fully developed, existing methods for the collection, handling, processing and storage of human sweat need to be revised. This review presents a cross-disciplinary overview of the origins, composition, physical characteristics and functional roles of human sweat, and explores the factors involved in standardising sweat collection for metabolomics analysis. Methods A literature review of human sweat analysis over the past 10 years (2006–2016) was performed to identify studies with metabolomics or similarly applicable ‘omics’ analysis. These studies were reviewed with attention to sweat induction and sampling techniques, timing of sweat collection, sweat storage conditions, laboratory derivation, processing and analytical platforms. Results Comparative analysis of 20 studies revealed numerous factors that can significantly impact the validity, reliability and reproducibility of sweat analysis including: anatomical site of sweat sampling, skin integrity and preparation; temperature and humidity at the sweat collection sites; timing and nature of sweat collection; metabolic quenching; transport and storage; qualitative and quantitative measurements of the skin microbiota at sweat collection sites; and individual variables such as diet, emotional state, metabolic conditions, pharmaceutical, recreational drug and supplement use. Conclusion Further development of standard operating protocols for human sweat collection can open the way for sweat metabolomics to significantly add to our understanding of human physiology in health and disease. PMID:28798503

The role of information communication technology (ICT) towards universal health coverage: the first steps of a telemedicine project in Ethiopia

PubMed Central

Shiferaw, Fassil; Zolfo, Maria

2012-01-01

Background Eighty-five per cent of the Ethiopian population lives in remote areas, without access to modern health services. The limited health care budget, chronic shortage of health care workers and lack of incentives to retain those in remote areas further jeopardize the national health care delivery system. Recently, the application of information communication technology (ICT) to health care delivery and the use of telemedicine have raised hopes. Objective This paper analyzes the challenges, failures and successes encountered in setting-up and implementing a telemedicine program in Ethiopia and provides possible recommendations for developing telemedicine strategies in countries with limited resources. Design Ten sites in Ethiopia were selected to participate in this pilot between 2004 and 2006 and twenty physicians, two per site, were trained in the use of a store and forward telemedicine system, using a dial-up internet connection. Teledermatology, teleradiology and telepathology were the chosen disciplines for the electronic referrals, across the selected ten sites. Results Telemedicine implementation does not depend only on technological factors, rather on e-government readiness, enabling policies, multisectoral involvement and capacity building processes. There is no perfect ‘one size fits all’ technology and the use of combined interoperable applications, according to the local context, is highly recommended. Conclusions Telemedicine is still in a premature phase of development in Ethiopia and other sub-Saharan African countries, and it remains difficult to talk objectively about measurable impact of its use, even though it has demonstrated practical applicability beyond reasonable doubts. PMID:22479235

Programmable Automated Welding System (PAWS): Control of welding through software and hardware

NASA Technical Reports Server (NTRS)

Kline, Martin D.; Doyle, Thomas E.

1994-01-01

The ATD phase of the PAWS program ended in November 1992 and the follow-on ManTech program was started in September 1993. The system will be industrially hardened during the first year of this program. Follow-on years will focus upon the transition into specific end-user sites. These implementations will also expand the system into other welding processes (e.g. FCAW, GTAW, PAW). In addition, the architecture is being developed for application to other non-welding robotic processes (e.g. inspection, surface finishing). Future development is anticipated to encompass hardening for extreme environments, expanded exception handling techniques, and application to a range of manipulators.

GRAPHICS MANAGER (GFXMGR): An interactive graphics software program for the Advanced Electronics Design (AED) graphics controller, Model 767

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faculjak, D.A.

1988-03-01

Graphics Manager (GFXMGR) is menu-driven, user-friendly software designed to interactively create, edit, and delete graphics displays on the Advanced Electronics Design (AED) graphics controller, Model 767. The software runs on the VAX family of computers and has been used successfully in security applications to create and change site layouts (maps) of specific facilities. GFXMGR greatly benefits graphics development by minimizing display-development time, reducing tedium on the part of the user, and improving system performance. It is anticipated that GFXMGR can be used to create graphics displays for many types of applications. 8 figs., 2 tabs.

Data Integration Tool: From Permafrost Data Translation Research Tool to A Robust Research Application

NASA Astrophysics Data System (ADS)

Wilcox, H.; Schaefer, K. M.; Jafarov, E. E.; Strawhacker, C.; Pulsifer, P. L.; Thurmes, N.

2016-12-01

The United States National Science Foundation funded PermaData project led by the National Snow and Ice Data Center (NSIDC) with a team from the Global Terrestrial Network for Permafrost (GTN-P) aimed to improve permafrost data access and discovery. We developed a Data Integration Tool (DIT) to significantly speed up the time of manual processing needed to translate inconsistent, scattered historical permafrost data into files ready to ingest directly into the GTN-P. We leverage this data to support science research and policy decisions. DIT is a workflow manager that divides data preparation and analysis into a series of steps or operations called widgets. Each widget does a specific operation, such as read, multiply by a constant, sort, plot, and write data. DIT allows the user to select and order the widgets as desired to meet their specific needs. Originally it was written to capture a scientist's personal, iterative, data manipulation and quality control process of visually and programmatically iterating through inconsistent input data, examining it to find problems, adding operations to address the problems, and rerunning until the data could be translated into the GTN-P standard format. Iterative development of this tool led to a Fortran/Python hybrid then, with consideration of users, licensing, version control, packaging, and workflow, to a publically available, robust, usable application. Transitioning to Python allowed the use of open source frameworks for the workflow core and integration with a javascript graphical workflow interface. DIT is targeted to automatically handle 90% of the data processing for field scientists, modelers, and non-discipline scientists. It is available as an open source tool in GitHub packaged for a subset of Mac, Windows, and UNIX systems as a desktop application with a graphical workflow manager. DIT was used to completely translate one dataset (133 sites) that was successfully added to GTN-P, nearly translate three datasets (270 sites), and is scheduled to translate 10 more datasets ( 1000 sites) from the legacy inactive site data holdings of the Frozen Ground Data Center (FGDC). Iterative development has provided the permafrost and wider scientific community with an extendable tool designed specifically for the iterative process of translating unruly data.

Status of FEP encapsulated solar cell modules used in terrestrial applications

NASA Technical Reports Server (NTRS)

Ratajczak, A. F.; Forestieri, A. F.

1974-01-01

The Lewis Research Center has been engaged in transferring the FEP encapsulated solar cell technology developed for the space program to terrestrial applications. FEP encapsulated solar cell modules and arrays were designed and built expressly for terrestrial applications. Solar cell power systems were installed at three different land sites, while individual modules are undergoing marine environment tests. Four additional power systems are being completed for installation during the summer of 1974. These tests have revealed some minor problems which have been corrected. The results confirm the inherent utility of FEP encapsulated terrestrial solar cell systems.

New York Times Current News Physics Applications

NASA Astrophysics Data System (ADS)

Cise, John

2010-03-01

Since 2007 I have been using NYTimes current News articles rich in graphics and physics variables for developing edited one page web (http://CisePhysics.homestead.com/files/NYT.htm) physics questions based on current events in the news. The NYTimes home page listed above contains currently ten pages with about 40 one page current edited News related physics articles per page containing: rich graphics, graphic editions by the author, edited articles, introduction to a question, questions, and answers. I use these web pages to introduce new physics concepts to students with current applications of concepts in the news. I also use these one page physics applications as pop quizzes and extra credit for students. As news happens(e.g. the 2010 Vancouver Olympics) I find the physics applications in the NYTimes articles and generate applications and questions. These new one page applications with questions are added to the home page: http://CisePhysics.homestead.com/files/NYT.htm The newest pages start with page 10 and work back in time to 9, 8, etc. The ten web pages with about 40 news articles per page are arranged in the traditional manner: vectors, kinematics, projectiles, Newton, Work & Energy, properties of matter, fluids, temperature, heat, waves, and sound. This site is listed as a resource in AAPT's Compadre site.