Science.gov

Sample records for skewness

  1. Skew chromaticity

    SciTech Connect

    Peggs, S.; Dell, G.F.

    1994-12-31

    The on-momentum description of linear coupling between horizontal and vertical betatron motion is extended to include off-momentum particles, introducing a vector quantity called the ``skew chromaticity``. This vector tends to be long in large superconducting storage rings, where it restricts the available working space in the tune plane, and modifies collective effect stability criteria. Skew chromaticity measurements at the Cornell Electron Storage Ring (CESR) and at the Fermilab Tevatron are reported, as well as tracking results from the Relativistic Heavy Ion Collider (RHIC). The observation of anomalous head-tail beam Iowa new the tune diagonal in the Tevatron are explained in terms of the extended theory, including modified criteria for headtail stability. These results are confirmed in head-tail simulations. Sources of skew chromaticity are investigated.

  2. Quantum skew divergence

    SciTech Connect

    Audenaert, Koenraad M. R.

    2014-11-15

    In this paper, we study the quantum generalisation of the skew divergence, which is a dissimilarity measure between distributions introduced by Lee in the context of natural language processing. We provide an in-depth study of the quantum skew divergence, including its relation to other state distinguishability measures. Finally, we present a number of important applications: new continuity inequalities for the quantum Jensen-Shannon divergence and the Holevo information, and a new and short proof of Bravyi's Small Incremental Mixing conjecture.

  3. Skew resisting hydrodynamic seal

    DOEpatents

    Conroy, William T.; Dietle, Lannie L.; Gobeli, Jeffrey D.; Kalsi, Manmohan S.

    2001-01-01

    A novel hydrodynamically lubricated compression type rotary seal that is suitable for lubricant retention and environmental exclusion. Particularly, the seal geometry ensures constraint of a hydrodynamic seal in a manner preventing skew-induced wear and provides adequate room within the seal gland to accommodate thermal expansion. The seal accommodates large as-manufactured variations in the coefficient of thermal expansion of the sealing material, provides a relatively stiff integral spring effect to minimize pressure-induced shuttling of the seal within the gland, and also maintains interfacial contact pressure within the dynamic sealing interface in an optimum range for efficient hydrodynamic lubrication and environment exclusion. The seal geometry also provides for complete support about the circumference of the seal to receive environmental pressure, as compared the interrupted character of seal support set forth in U.S. Pat. Nos. 5,873,576 and 6,036,192 and provides a hydrodynamic seal which is suitable for use with non-Newtonian lubricants.

  4. Detecting skewness from summary information.

    PubMed

    Altman, D G; Bland, J M

    1996-11-01

    Many statistical methods of analysis assume that the data have a normal distribution. When the data do not, they can often be changed to make them more normal. However, readers of published papers may wish to be certain that the authors have conducted a proper analysis. One can clearly see whether the distributional assumption is met when data are presented in the form of a histogram or scatter diagram. However, when only summary statistics are presented, the task becomes far more difficult. An idea of the distribution can be gleaned if the summary statistics include the range of the data. For example, a range from 7 to 41 around a mean of 15 suggests that the data are positively skewed. Belief in that assumption may be unreliable because the range is based upon the two most extreme, and atypical, values. Similar asymmetry affecting the lower and upper quartiles would better indicate a skewed distribution. it is suggested that for measurements which must be positive, if the mean is smaller than twice the standard deviation, the data are likely to be skewed. A second indicator of skewness can be used when there are data for several groups of individuals. Deviations from the normal distribution and a relation between the standard deviation and mean across groups often go together. A standard deviation which increases as the mean increases is a strong indication of positively skewed data, and specifically that a log transformation may be needed.

  5. Skew chromaticity in large accelerators

    SciTech Connect

    Peggs, S.; Dell, G.F.

    1995-05-01

    The 2-D ``skew chromaticity`` vector k is introduced when the standard on-momentum description of linear coupling is extended to include off-momentum particles. A lattice that is well decoupled on-momentum may be badly decoupled off-momentum, inside the natural momentum spread of the beam. There are two general areas of concern: (1) the free space in the tune plane is decreased; (2) collective phenomena may be destabilized. Two strong new criteria for head-tail stability in the presence of off-momentum coupling are derived, which are consistent with experimental and operational observations at the Tevatron, and with tracking data from RHIC.

  6. Kinematic correction for roller skewing

    NASA Technical Reports Server (NTRS)

    Savage, M.; Loewenthal, S. H.

    1980-01-01

    A theory of kinematic stabilization of rolling cylinders is developed for high-speed cylindrical roller bearings. This stabilization requires race and roller crowning to product changes in the rolling geometry as the roller shifts axially. These changes put a reverse skew in the rolling elements by changing the rolling taper. Twelve basic possible bearing modifications are identified in this paper. Four have single transverse convex curvature in the rollers while eight have rollers with compound transverse curvature composed of a central cylindrical band of constant radius surrounded by symmetric bands with both slope and transverse curvature.

  7. Mixture of Skewed α-Stable Distributions

    NASA Astrophysics Data System (ADS)

    Shojaei, S. R. Hosseini; Nassiri, V.; Mohammadian, Gh. R.; Mohammadpour, A.

    2011-03-01

    Expectation maximization (EM) algorithm and the Bayesian techniques are two approaches for statistical inference of mixture models [3, 4]. By noting the advantages of the Bayesian methods, practitioners prefer them. However, implementing Markov chain Monte Carlo algorithms can be very complicated for stable distributions, due to the non-analytic density or distribution function formulas. In this paper, we introduce a new class of mixture of heavy-tailed distributions, called mixture of skewed stable distributions. Skewed stable distributions belongs to the exponential family and they have analytic density representation. It is shown that skewed stable distributions dominate skew stable distribution functions and they can be used to model heavy-tailed data. The class of skewed stable distributions has an analytic representation for its density function and the Bayesian inference can be done similar to the exponential family of distributions. Finally, mixture of skewed stable distributions are compared to the mixture of stable distributions through a simulations study.

  8. Roller skewing measurements in cylindrical roller bearings

    NASA Technical Reports Server (NTRS)

    Nypan, L. J.

    1981-01-01

    Measurements of roller skewing in a 118 mm bore roller bearing operating at shaft speeds to 12,000 rpm are reported. High speed motion pictures of a modified roller were taken through a derotation prism to record skewing as the roller moved through loaded and unloaded regions of the bearing. Subsequent frame by frame measurement of the photographic film provided information on roller skewing. Radial and tangential skew amplitudes of 0.4 to 0.5 degrees were observed with 0.5 degree misalignment.

  9. Modeling skewness in human transcriptomes.

    PubMed

    Casellas, Joaquim; Varona, Luis

    2012-01-01

    Gene expression data are influenced by multiple biological and technological factors leading to a wide range of dispersion scenarios, although skewed patterns are not commonly addressed in microarray analyses. In this study, the distribution pattern of several human transcriptomes has been studied on free-access microarray gene expression data. Our results showed that, even in previously normalized gene expression data, probe and differential expression within probe effects suffer from substantial departures from the commonly assumed symmetric gaussian distribution. We developed a flexible mixed model for non-competitive microarray data analysis that accounted for asymmetric and heavy-tailed (Student's t distribution) dispersion processes. Random effects for gene expression data were modeled under asymmetric Student's t distributions where the asymmetry parameter (λ) took values from perfect symmetry (λ = 0) to right- (λ>0) or left-side (λ>0) over-expression patterns. This approach was applied to four free-access human data sets and revealed clearly better model performance when comparing with standard approaches accounting for traditional symmetric gaussian distribution patterns. Our analyses on human gene expression data revealed a substantial degree of right-hand asymmetry for probe effects, whereas differential gene expression addressed both symmetric and left-hand asymmetric patterns. Although these results cannot be extrapolated to all microarray experiments, they highlighted the incidence of skew dispersion patterns in human transcriptome; moreover, we provided a new analytical approach to appropriately address this biological phenomenon. The source code of the program accommodating these analytical developments and additional information about practical aspects on running the program are freely available by request to the corresponding author of this article. PMID:22701729

  10. Portfolio optimization with skewness and kurtosis

    NASA Astrophysics Data System (ADS)

    Lam, Weng Hoe; Jaaman, Saiful Hafizah Hj.; Isa, Zaidi

    2013-04-01

    Mean and variance of return distributions are two important parameters of the mean-variance model in portfolio optimization. However, the mean-variance model will become inadequate if the returns of assets are not normally distributed. Therefore, higher moments such as skewness and kurtosis cannot be ignored. Risk averse investors prefer portfolios with high skewness and low kurtosis so that the probability of getting negative rates of return will be reduced. The objective of this study is to compare the portfolio compositions as well as performances between the mean-variance model and mean-variance-skewness-kurtosis model by using the polynomial goal programming approach. The results show that the incorporation of skewness and kurtosis will change the optimal portfolio compositions. The mean-variance-skewness-kurtosis model outperforms the mean-variance model because the mean-variance-skewness-kurtosis model takes skewness and kurtosis into consideration. Therefore, the mean-variance-skewness-kurtosis model is more appropriate for the investors of Malaysia in portfolio optimization.

  11. Skew-flavored dark matter

    DOE PAGES

    Agrawal, Prateek; Chacko, Zackaria; Fortes, Elaine C. F. S.; Kilic, Can

    2016-05-10

    We explore a novel flavor structure in the interactions of dark matter with the Standard Model. We consider theories in which both the dark matter candidate, and the particles that mediate its interactions with the Standard Model fields, carry flavor quantum numbers. The interactions are skewed in flavor space, so that a dark matter particle does not directly couple to the Standard Model matter fields of the same flavor, but only to the other two flavors. This framework respects minimal flavor violation and is, therefore, naturally consistent with flavor constraints. We study the phenomenology of a benchmark model in whichmore » dark matter couples to right-handed charged leptons. In large regions of parameter space, the dark matter can emerge as a thermal relic, while remaining consistent with the constraints from direct and indirect detection. The collider signatures of this scenario include events with multiple leptons and missing energy. In conclusion, these events exhibit a characteristic flavor pattern that may allow this class of models to be distinguished from other theories of dark matter.« less

  12. Reproductive skew in the polygynandrous acorn woodpecker.

    PubMed

    Haydock, Joseph; Koenig, Walter D

    2002-05-14

    Reproductive skew models, which focus on the degree to which reproduction is shared equally (low skew) or monopolized by a single individual (high skew) within groups, have been heralded as providing a general unifying framework for understanding the factors determining social evolution. Here, we test the ability of optimal skew, or "transactional," models, which predict the level of skew necessary to promote stable associations of dominants and subordinates, rather than independent breeding, to predict reproductive partitioning in the acorn woodpecker (Melanerpes formicivorus). This species provides a key test case because only a few vertebrates exhibit polygynandry (multiple breeders of both sexes within a group). Contrary to the predictions of the models, joint-nesting females share reproduction more equitably than expected, apparently because egg destruction and the inability of females to defend their eggs from cobreeders eliminate any possibility for one female to control reproduction. For males, however, reproductive skew is high, with the most successful male siring over three times as many young as the next most successful male. Although this result is consistent with optimal skew models, other aspects of male behavior are not; in particular, the reproductively most successful male frequently switches between nests produced by the same set of cobreeders, and we were unable to detect any phenotypic correlate of success. These results are consistent with an alternative null model in which cobreeder males have equal chance of paternity, but paternity of offspring within broods is nonindependent as a consequence of female, rather than male, control.

  13. SKEW QUADRUPOLE FOCUSING LATTICES AND APPLICATIONS.

    SciTech Connect

    PARKER,B.

    2001-06-18

    In this paper we revisit using skew quadrupole fields in place of traditional normal upright quadrupole fields to make beam focusing structures. We illustrate by example skew lattice decoupling, dispersion suppression and chromatic correction using the neutrino factory Study-II muon storage ring design. Ongoing BNL investigation of flat coil magnet structures that allow building a very compact muon storage ring arc and other flat coil configurations that might bring significant magnet cost reduction to a VLHC motivate our study of skew focusing.

  14. Tunable skewed edges in puckered structures

    NASA Astrophysics Data System (ADS)

    Grujić, Marko M.; Ezawa, Motohiko; Tadić, Milan Ž.; Peeters, François M.

    2016-06-01

    We propose a type of edges arising due to the anisotropy inherent in the puckered structure of a honeycomb system such as in phosphorene. Skewed-zigzag and skewed-armchair nanoribbons are semiconducting and metallic, respectively, in contrast to their normal edge counterparts. Their band structures are tunable, and a metal-insulator transition is induced by an electric field. We predict a field-effect transistor based on the edge states in skewed-armchair nanoribbons, where the edge state is gapped by applying arbitrary small electric field Ez. A topological argument is presented, revealing the condition for the emergence of such edge states.

  15. Women's Memory Advantage Might Skew Alzheimer's Diagnosis

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_161328.html Women's Memory Advantage Might Skew Alzheimer's Diagnosis Women tend to hold on to better verbal memory skills as they age compared to men, study ...

  16. Skew estimation of document images using bagging.

    PubMed

    Meng, Gaofeng; Pan, Chunhong; Zheng, Nanning; Sun, Chen

    2010-07-01

    This paper proposes a general-purpose method for estimating the skew angles of document images. Rather than to derive a skew angle merely from text lines, the proposed method exploits various types of visual cues of image skew available in local image regions. The visual cues are extracted by Radon transform and then outliers of them are iteratively rejected through a floating cascade. A bagging (bootstrap aggregating) estimator is finally employed to combine the estimations on the local image blocks. Our experimental results show significant improvements against the state-of-the-art methods, in terms of execution speed and estimation accuracy, as well as the robustness to short and sparse text lines, multiple different skews and the presence of nontextual objects of various types and quantities.

  17. High reproductive skew in tropical hover wasps.

    PubMed

    Sumner, Seirian; Casiraghi, Maurizio; Foster, William; Field, Jeremy

    2002-01-22

    A plethora of recent models examines how genetic and environmental factors might influence partitioning of reproduction ('skew') in animal societies, but empirical data are sparse. We used three microsatellite loci to estimate skew on 13 nests of the Malaysian hover wasp, Liostenogaster flavolineata. Groups are small in L. flavolineata (1-10 females) and all females are capable of mating and laying eggs. Despite considerable variation between nests in parameters expected to influence skew, skew was uniformly high. On 11 of the 13 nests, all female eggs had been laid by a single dominant female. A second female had laid one to two out of 5-10 eggs respectively on the two remaining nests. A likelihood analysis suggested that on average, 90% of the male eggs had also been laid by the dominant. The slightly lower skew among male eggs might reflect the lower average relatedness of subordinates to male versus female offspring of the dominant. We suggest that high skew in L. flavolineata may result from strong ecological constraints and a relatively high probability that a subordinate will eventually inherit the dominant, egg-laying position.

  18. Static ocular counterroll reflex in skew deviation

    PubMed Central

    Chandrakumar, M.; Blakeman, A.; Goltz, H.C.; Sharpe, J.A.

    2011-01-01

    Objective: The static ocular counterroll (OCR) reflex generates partially compensatory torsional eye movements during head roll. It is mediated by the utricle in the inner ear. Skew deviation is a vertical strabismus thought to be caused by imbalance in the utriculo-ocular pathway. We hypothesized that if skew deviation is indeed caused by damage to this reflex pathway, patients with skew deviation would show abnormal OCR. Methods: Eighteen patients with skew deviation caused by brainstem or cerebellar lesions and 18 normal participants viewed a target at 1 m. Ocular responses to static passive head roll-tilts of approximately 20° were recorded using search coils. Static OCR gain was calculated as the change in torsional eye position divided by the change in head position during sustained head roll. Perception of the subjective visual vertical (SVV) was also measured. Results: Group mean OCR gain was reduced by 45% in patients. At an individual level, OCR gains were asymmetric between eyes and between torsional directions in 90% of patients. In addition, the hypotropic eye incyclotorting gain was lower than the hypertropic eye excyclotorting gain during head roll toward the hypotropic eye in 94% of patients. No consistent pattern of gain asymmetry was found during head roll toward the hypertropic eye. The SVV was tilted toward the hypotropic eye. Conclusion: Static OCR gain is significantly reduced in skew deviation. Interocular and directional gain asymmetries are also prevalent. The asymmetries provide further evidence that disruption of the utriculo-ocular pathway is a mechanism for skew deviation. PMID:21813791

  19. Skewness and Kurtosis in Statistical Kinetics

    NASA Astrophysics Data System (ADS)

    Barato, Andre C.; Seifert, Udo

    2015-10-01

    We obtain lower and upper bounds on the skewness and kurtosis associated with the cycle completion time of unicyclic enzymatic reaction schemes. Analogous to a well-known lower bound on the randomness parameter, the lower bounds on skewness and kurtosis are related to the number of intermediate states in the underlying chemical reaction network. Our results demonstrate that evaluating these higher order moments with single molecule data can lead to information about the enzymatic scheme that is not contained in the randomness parameter.

  20. Skew chicane based betatron eigenmode exchange module

    DOEpatents

    Douglas, David

    2010-12-28

    A skewed chicane eigenmode exchange module (SCEEM) that combines in a single beamline segment the separate functionalities of a skew quad eigenmode exchange module and a magnetic chicane. This module allows the exchange of independent betatron eigenmodes, alters electron beam orbit geometry, and provides longitudinal parameter control with dispersion management in a single beamline segment with stable betatron behavior. It thus reduces the spatial requirements for multiple beam dynamic functions, reduces required component counts and thus reduces costs, and allows the use of more compact accelerator configurations than prior art design methods.

  1. Optimal Weak-Lensing Skewness Measurements

    NASA Astrophysics Data System (ADS)

    Zhang, Tong-Jie; Pen, Ue-Li; Zhang, Pengjie; Dubinski, John

    2003-12-01

    Weak-lensing measurements are starting to provide statistical maps of the distribution of matter in the universe that are increasingly precise and complementary to cosmic microwave background maps. The most common measurement is the correlation in alignments of background galaxies, which can be used to infer the variance of the projected surface density of matter. This measurement of the fluctuations is insensitive to the total mass content and is analogous to using waves on the ocean to measure its depths. However, when the depth is shallow, as happens near a beach, waves become skewed. Similarly, a measurement of skewness in the projected matter distribution directly measures the total matter content of the universe. While skewness has already been convincingly detected, its constraint on cosmology is still weak. We address optimal analyses for the Canada-France-Hawaii Telescope Legacy Survey in the presence of noise. We show that a compensated Gaussian filter with a width of 2.5‧ optimizes the cosmological constraint, yielding ΔΩm/Ωm~10%. This is significantly better than other filters that have been considered in the literature. This can be further improved with tomography and other sophisticated analyses.

  2. Generalized skew coefficients for flood-frequency analysis in Minnesota

    USGS Publications Warehouse

    Lorenz, D.L.

    1997-01-01

    This report presents an evaluation of generalized skew coefficients used in flood-frequency analysis. Station skew coefficients were computed for 267 long-term stream-gaging stations in Minnesota and the surrounding states of Iowa, North and South Dakota, Wisconsin, and the provinces of Manitoba and Ontario, Canada. Generalized skew coefficients were computed from station skew coefficients using a locally weighted regression technique. The resulting regression trend surface was the generalized skew coefficient map, except for the North Shore area, and has a mean square error of 0.182.

  3. Dynamic Modeling from Flight Data with Unknown Time Skews

    NASA Technical Reports Server (NTRS)

    Morelli, Eugene A.

    2016-01-01

    A method for estimating dynamic model parameters from flight data with unknown time skews is described and demonstrated. The method combines data reconstruction, nonlinear optimization, and equation-error parameter estimation in the frequency domain to accurately estimate both dynamic model parameters and the relative time skews in the data. Data from a nonlinear F-16 aircraft simulation with realistic noise, instrumentation errors, and arbitrary time skews were used to demonstrate the approach. The approach was further evaluated using flight data from a subscale jet transport aircraft, where the measured data were known to have relative time skews. Comparison of modeling results obtained from time-skewed and time-synchronized data showed that the method accurately estimates both dynamic model parameters and relative time skew parameters from flight data with unknown time skews.

  4. Inferring climate variability from skewed proxy records

    NASA Astrophysics Data System (ADS)

    Emile-Geay, J.; Tingley, M.

    2013-12-01

    Many paleoclimate analyses assume a linear relationship between the proxy and the target climate variable, and that both the climate quantity and the errors follow normal distributions. An ever-increasing number of proxy records, however, are better modeled using distributions that are heavy-tailed, skewed, or otherwise non-normal, on account of the proxies reflecting non-normally distributed climate variables, or having non-linear relationships with a normally distributed climate variable. The analysis of such proxies requires a different set of tools, and this work serves as a cautionary tale on the danger of making conclusions about the underlying climate from applications of classic statistical procedures to heavily skewed proxy records. Inspired by runoff proxies, we consider an idealized proxy characterized by a nonlinear, thresholded relationship with climate, and describe three approaches to using such a record to infer past climate: (i) applying standard methods commonly used in the paleoclimate literature, without considering the non-linearities inherent to the proxy record; (ii) applying a power transform prior to using these standard methods; (iii) constructing a Bayesian model to invert the mechanistic relationship between the climate and the proxy. We find that neglecting the skewness in the proxy leads to erroneous conclusions and often exaggerates changes in climate variability between different time intervals. In contrast, an explicit treatment of the skewness, using either power transforms or a Bayesian inversion of the mechanistic model for the proxy, yields significantly better estimates of past climate variations. We apply these insights in two paleoclimate settings: (1) a classical sedimentary record from Laguna Pallcacocha, Ecuador (Moy et al., 2002). Our results agree with the qualitative aspects of previous analyses of this record, but quantitative departures are evident and hold implications for how such records are interpreted, and

  5. GC skew and mitochondrial origins of replication.

    PubMed

    Sahyoun, Abdullah H; Bernt, Matthias; Stadler, Peter F; Tout, Kifah

    2014-07-01

    The comprehensive understanding of mitochondrial genome evolution requires a detailed mechanistic picture of mitogenomic replication. Despite many previous efforts it has remained a non-trivial problem to determine the origins of replication and trace their fate across rearrangements of the gene order even in the small genomes of animal mitochondria. We elaborate here on the observation that the GC skew is correlated with the distance from the replication origins. This effect has been explained as a consequence of the standard model of mitochondrial DNA replication, i.e. the strand displacement model. According to this model chemical damage accumulates proportional to the duration that DNA is exposed in single-stranded form during replication (Dssh) which depends on the relative position with respect to the replication origins. Based on this model we developed a computational method to infer the positions of both the heavy strand and the light strand origin from nucleotide skew data. In a comprehensive survey of deuterostome mitochondria we infer conserved replication origins for the vast majority of vertebrates and cephalochordates. Deviations from the consensus picture are presumably associated with genome rearrangements.

  6. Temperature-Compensated Clock Skew Adjustment

    PubMed Central

    Castillo-Secilla, Jose María; Palomares, Jose Manuel; Olivares, Joaquín

    2013-01-01

    This work analyzes several drift compensation mechanisms in wireless sensor networks (WSN). Temperature is an environmental factor that greatly affects oscillators shipped in every WSN mote. This behavior creates the need of improving drift compensation mechanisms in synchronization protocols. Using the Flooding Time Synchronization Protocol (FTSP), this work demonstrates that crystal oscillators are affected by temperature variations. Thus, the influence of temperature provokes a low performance of FTSP in changing conditions of temperature. This article proposes an innovative correction factor that minimizes the impact of temperature in the clock skew. By means of this factor, two new mechanisms are proposed in this paper: the Adjusted Temperature (AT) and the Advanced Adjusted Temperature (A2T). These mechanisms have been combined with FTSP to produce AT-FTSP and A2T-FTSP Both have been tested in a network of TelosB motes running TinyOS. Results show that both AT-FTSP and A2T-FTSP improve the average synchronization errors compared to FTSP and other temperature-compensated protocols (Environment-Aware Clock Skew Estimation and Synchronization for WSN (EACS) and Temperature Compensated Time Synchronization (TCTS)). PMID:23966192

  7. Evolution and models for skewed parton distribution

    SciTech Connect

    Musatov, I.C.; Radyushkin, A.V.

    1999-05-17

    The authors discuss the structure of the ''forward visible'' (FW) parts of double and skewed distributions related to usual distributions through reduction relations. They use factorized models for double distributions (DDs) {tilde f}(x,{alpha}) in which one factor coincides with the usual (forward) parton distribution and another specifies the profile characterizing the spread of the longitudinal momentum transfer. The model DDs are used to construct skewed parton distributions (SPDs). For small skewedness, the FW parts of SPDs H ({tilde x},{xi}) can be obtained by averaging forward parton densities f({tilde x}-{xi}{alpha}) with the weight {rho}({alpha}) coinciding with the profile function of the double distribution {tilde f}(x, {alpha}) at small x. They show that if the x{sup n} moments {tilde f}{sub n}({alpha}) of DDs have the asymptotic (1-{alpha}{sup 2}){sup n+1} profile, then the {alpha}-profile of {tilde f}(x,{alpha}) for small x is completely determined by small-x behavior of the usual parton distribution. They demonstrate that, for small {xi}, the model with asymptotic profiles for {tilde f}{sub n}({alpha}) is equivalent to that proposed recently by Shuvaev et al., in which the Gegenbauer moments of SPDs do not depend on {xi}. They perform a numerical investigation of the evolution patterns of SPDs and give interpretation of the results of these studies within the formalism of double distributions.

  8. Coefficient of variation calculated from the range for skewed distributions.

    PubMed

    Rhiel, G Steven

    2006-02-01

    In this research a coefficient of variation (CVS(high.low)) is developed that is calculated from the highest and lowest values in a set of data for samples from skewed distributions. A correction factor is determined such that CVS(high-low) is a dose estimate of the population coefficient of variation when sampling from three skewed chi-squared distributions and three skewed empirical distributions. The empirical distributions are from "real-world" data sets in psychology and education.

  9. Analysis of skew plate problems with various constraints

    NASA Astrophysics Data System (ADS)

    Mizusawa, T.; Kajita, T.; Naruoka, M.

    1980-12-01

    This paper presents the application of the modified Rayleigh-Ritz method with Lagrange multipliers to analyze skew plate problems with various constraints. By this procedure one can satisfy both geometric and natural boundary conditions of skew plates. To demonstrate the accuracy and versatility of the method, several examples of bending, vibration and buckling of skew plates are solved, and results are compared with those obtained by other approximate methods.

  10. Robust skew estimation using straight lines in document images

    NASA Astrophysics Data System (ADS)

    Koo, Hyung Il; Cho, Nam Ik

    2016-05-01

    A skew-estimation method using straight lines in document images is presented. Unlike conventional approaches exploiting the properties of text, we formulate the skew-estimation problem as an estimation task using straight lines in images and focus on robust and accurate line detection. To be precise, we adopt a block-based edge detector followed by a progressive line detector to take clues from a variety of sources such as text lines, boundaries of figures/tables, vertical/horizontal separators, and boundaries of textblocks. Extensive experiments on the datasets of skewed images and competition results reveal that the proposed method works robustly and yields accurate skew-estimation results.

  11. Cracked shells under skew-symmetric loading

    NASA Technical Reports Server (NTRS)

    Lelale, F.

    1982-01-01

    A shell containing a through crack in one of the principal planes of curvature and under general skew-symmetric loading is considered. By employing a Reissner type shell theory which takes into account the effect of transverse shear strains, all boundary conditions on the crack surfaces are satisfied separately. Consequently, unlike those obtained from the classical shell theory, the angular distributions of the stress components around the crack tips are shown to be identical to the distributions obtained from the plane and antiplane elasticity solutions. Extensive results are given for axially and circumferentially cracked cylindrical shells, spherical shells, and toroidal shells under uniform inplane shearing, out of plane shearing, and torsion. The effect of orthotropy on the results is also studied.

  12. Incorporating covariates in skewed functional data models.

    PubMed

    Li, Meng; Staicu, Ana-Maria; Bondell, Howard D

    2015-07-01

    We introduce a class of covariate-adjusted skewed functional models (cSFM) designed for functional data exhibiting location-dependent marginal distributions. We propose a semi-parametric copula model for the pointwise marginal distributions, which are allowed to depend on covariates, and the functional dependence, which is assumed covariate invariant. The proposed cSFM framework provides a unifying platform for pointwise quantile estimation and trajectory prediction. We consider a computationally feasible procedure that handles densely as well as sparsely observed functional data. The methods are examined numerically using simulations and is applied to a new tractography study of multiple sclerosis. Furthermore, the methodology is implemented in the R package cSFM, which is publicly available on CRAN.

  13. Accounting for Skewness in Ensemble Data Assimilation

    NASA Astrophysics Data System (ADS)

    Hodyss, D.

    2011-12-01

    I will discuss a new framework for understanding how a non-normal probability density function (pdf) may affect a state estimate and how one might usefully exploit the non-normal properties of the pdf when constructing a state estimate. A Bayesian framework is constructed that leads naturally to an expansion of the expected forecast error in a polynomial series consisting of powers of the innovation vector. This polynomial expansion in the innovation reveals a new view of the geometric nature of the state estimation problem. Among other things a direct relationship is shown between the degree to which the state estimate varies with the innovation and the moments of the distribution. A practical data assimilation algorithm will also be presented that explicitly accounts for skewness in the prior distribution. The algorithm operates as a global-solve using a conjugate-gradient technique and Schur/Hadamard (element-wise) localization, and as a general rule is only a factor of four more expensive than the traditional ensemble Kalman filter. The central feature of this technique is the squaring of the innovation and the ensemble perturbations so as to create an extended state-space that accounts for the second, third and fourth moments of the prior distribution. This new technique is illustrated in a simple scalar system as well as in a Boussinesq model of O(10000) variables configured to simulate nonlinearly evolving Kelvin-Helmholtz waves in shear flow. It is shown that ensemble sizes of at least 100 members is needed to adequately resolve the third and fourth moments required for the algorithm. For ensembles of this size it is shown that this new technique is superior to a state-of-the-art Ensemble Kalman Filter in situations with significant skewness, otherwise the new algorithm reduces to the performance of the Ensemble Kalman Filter.

  14. Evolution and models for skewed parton distributions

    SciTech Connect

    Musatov, I. V.; Radyushkin, A. V.

    2000-04-01

    We discuss the structure of the ''forward visible'' (FV) parts of double and skewed distributions related to the usual distributions through reduction relations. We use factorized models for double distributions (DD's) f(tilde sign)(x,{alpha}) in which one factor coincides with the usual (forward) parton distribution and another specifies the profile characterizing the spread of the longitudinal momentum transfer. The model DD's are used to construct skewed parton distributions (SPD's). For small skewedness, the FV parts of SPD's H(x(tilde sign),{xi}) can be obtained by averaging forward parton densities f(x(tilde sign)-{xi}{alpha}) with the weight {rho}({alpha}) coinciding with the profile function of the double distribution f(tilde sign)(x,{alpha}) at small x. We show that if the x{sup n} moments f(tilde sign){sub n}({alpha}) of DD's have the asymptotic (1-{alpha}{sup 2}){sup n+1} profile, then the {alpha} profile of f(tilde sign)(x,{alpha}) for small x is completely determined by the small-x behavior of the usual parton distribution. We demonstrate that, for small {xi}, the model with asymptotic profiles for f(tilde sign){sub n}({alpha}) is equivalent to that proposed recently by Shuvaev et al., in which the Gegenbauer moments of SPD's do not depend on {xi}. We perform a numerical investigation of the evolution patterns of SPD's and give an interpretation of the results of these studies within the formalism of double distributions. (c) 2000 The American Physical Society.

  15. Learning a Novel Pattern through Balanced and Skewed Input

    ERIC Educational Resources Information Center

    McDonough, Kim; Trofimovich, Pavel

    2013-01-01

    This study compared the effectiveness of balanced and skewed input at facilitating the acquisition of the transitive construction in Esperanto, characterized by the accusative suffix "-n" and variable word order (SVO, OVS). Thai university students (N = 98) listened to 24 sentences under skewed (one noun with high token frequency) or…

  16. A Method for Controlling Skew on Linked Surfaces

    SciTech Connect

    BENZLEY,STEVEN E.; KERR,ROBERT A.; MITCHELL,SCOTT A.; WHITE,DAVID R.

    1999-09-27

    A new method for lessening skew in mapped meshes is presented. This new method involves progressive subdivision of a surface into loops consisting of four sides. Using these loops, constraints can then be set on the curves of the surface, which will propagate interval assignments across the surface, allowing a mesh with a better skew metric to be generated.

  17. Analysis of carbon dioxide concentration skewness at a rural site.

    PubMed

    Pérez, Isidro A; Sánchez, M Luisa; García, M Ángeles; Ozores, Marta; Pardo, Nuria

    2014-04-01

    This paper provides evidence that symmetry of CO2 concentration distribution may indicate sources or dispersive processes. Skewness was calculated by different procedures with CO2 measured at a rural site using a Picarro G1301 analyser over a two-year period. The usual skewness coefficient was considered together with fourteen robust estimators. A noticeable contrast was obtained between day and night, and skewness decreased linearly with the logarithm of the height. One coefficient was selected from its satisfactory relationship with the median concentration in daily evolution. Three analyses based on the kernel smoothing method were conducted with this coefficient to investigate its response to yearly and daily evolutions, wind direction, and wind speed. Left-skewed distributions were linked to thermal turbulence during midday, especially in spring-summer, or with high wind speeds. Almost symmetric distributions were associated with sources, such as the Valladolid City plume reinforced with spring emissions and the lack of emissions in summer in the remaining directions. Finally, right-skewed distributions were related to low wind speeds and stable stratification at night, furthered by strong emissions in spring. Skewness intervals were proposed and their average median concentrations were calculated such that the relationship between skewness and concentration depends on the analysis performed. Since some skewness coefficients may also be negative, they provide better information about sources or dispersive processes than concentration.

  18. Investigating the Investigative Task: Testing for Skewness--An Investigation of Different Test Statistics and Their Power to Detect Skewness

    ERIC Educational Resources Information Center

    Tabor, Josh

    2010-01-01

    On the 2009 AP[c] Statistics Exam, students were asked to create a statistic to measure skewness in a distribution. This paper explores several of the most popular student responses and evaluates which statistic performs best when sampling from various skewed populations. (Contains 8 figures, 3 tables, and 4 footnotes.)

  19. Female reproductive synchrony predicts skewed paternity across primates

    PubMed Central

    Nunn, Charles L.; Schülke, Oliver

    2008-01-01

    Recent studies have uncovered remarkable variation in paternity within primate groups. To date, however, we lack a general understanding of the factors that drive variation in paternity skew among primate groups and across species. Our study focused on hypotheses from reproductive skew theory involving limited control and the use of paternity “concessions” by investigating how paternity covaries with the number of males, female estrous synchrony, and rates of extragroup paternity. In multivariate and phylogenetically controlled analyses of data from 27 studies on 19 species, we found strong support for a limited control skew model, with reproductive skew within groups declining as female reproductive synchrony and the number of males per group increase. Of these 2 variables, female reproductive synchrony explained more of the variation in paternity distributions. To test whether dominant males provide incentives to subordinates to resist matings by extragroup males, that is, whether dominants make concessions of paternity, we derived a novel prediction that skew is lower within groups when threat from outside the group exists. This prediction was not supported as a primary factor underlying patterns of reproductive skew among primate species. However, our approach revealed that if concessions occur in primates, they are most likely when female synchrony is low, as these conditions provide alpha male control of paternity that is assumed by concessions models. Collectively, our analyses demonstrate that aspects of male reproductive competition are the primary drivers of reproductive skew in primates. PMID:19018288

  20. Utility functions predict variance and skewness risk preferences in monkeys.

    PubMed

    Genest, Wilfried; Stauffer, William R; Schultz, Wolfram

    2016-07-26

    Utility is the fundamental variable thought to underlie economic choices. In particular, utility functions are believed to reflect preferences toward risk, a key decision variable in many real-life situations. To assess the validity of utility representations, it is therefore important to examine risk preferences. In turn, this approach requires formal definitions of risk. A standard approach is to focus on the variance of reward distributions (variance-risk). In this study, we also examined a form of risk related to the skewness of reward distributions (skewness-risk). Thus, we tested the extent to which empirically derived utility functions predicted preferences for variance-risk and skewness-risk in macaques. The expected utilities calculated for various symmetrical and skewed gambles served to define formally the direction of stochastic dominance between gambles. In direct choices, the animals' preferences followed both second-order (variance) and third-order (skewness) stochastic dominance. Specifically, for gambles with different variance but identical expected values (EVs), the monkeys preferred high-variance gambles at low EVs and low-variance gambles at high EVs; in gambles with different skewness but identical EVs and variances, the animals preferred positively over symmetrical and negatively skewed gambles in a strongly transitive fashion. Thus, the utility functions predicted the animals' preferences for variance-risk and skewness-risk. Using these well-defined forms of risk, this study shows that monkeys' choices conform to the internal reward valuations suggested by their utility functions. This result implies a representation of utility in monkeys that accounts for both variance-risk and skewness-risk preferences. PMID:27402743

  1. Utility functions predict variance and skewness risk preferences in monkeys

    PubMed Central

    Genest, Wilfried; Stauffer, William R.; Schultz, Wolfram

    2016-01-01

    Utility is the fundamental variable thought to underlie economic choices. In particular, utility functions are believed to reflect preferences toward risk, a key decision variable in many real-life situations. To assess the validity of utility representations, it is therefore important to examine risk preferences. In turn, this approach requires formal definitions of risk. A standard approach is to focus on the variance of reward distributions (variance-risk). In this study, we also examined a form of risk related to the skewness of reward distributions (skewness-risk). Thus, we tested the extent to which empirically derived utility functions predicted preferences for variance-risk and skewness-risk in macaques. The expected utilities calculated for various symmetrical and skewed gambles served to define formally the direction of stochastic dominance between gambles. In direct choices, the animals’ preferences followed both second-order (variance) and third-order (skewness) stochastic dominance. Specifically, for gambles with different variance but identical expected values (EVs), the monkeys preferred high-variance gambles at low EVs and low-variance gambles at high EVs; in gambles with different skewness but identical EVs and variances, the animals preferred positively over symmetrical and negatively skewed gambles in a strongly transitive fashion. Thus, the utility functions predicted the animals’ preferences for variance-risk and skewness-risk. Using these well-defined forms of risk, this study shows that monkeys’ choices conform to the internal reward valuations suggested by their utility functions. This result implies a representation of utility in monkeys that accounts for both variance-risk and skewness-risk preferences. PMID:27402743

  2. Utility functions predict variance and skewness risk preferences in monkeys.

    PubMed

    Genest, Wilfried; Stauffer, William R; Schultz, Wolfram

    2016-07-26

    Utility is the fundamental variable thought to underlie economic choices. In particular, utility functions are believed to reflect preferences toward risk, a key decision variable in many real-life situations. To assess the validity of utility representations, it is therefore important to examine risk preferences. In turn, this approach requires formal definitions of risk. A standard approach is to focus on the variance of reward distributions (variance-risk). In this study, we also examined a form of risk related to the skewness of reward distributions (skewness-risk). Thus, we tested the extent to which empirically derived utility functions predicted preferences for variance-risk and skewness-risk in macaques. The expected utilities calculated for various symmetrical and skewed gambles served to define formally the direction of stochastic dominance between gambles. In direct choices, the animals' preferences followed both second-order (variance) and third-order (skewness) stochastic dominance. Specifically, for gambles with different variance but identical expected values (EVs), the monkeys preferred high-variance gambles at low EVs and low-variance gambles at high EVs; in gambles with different skewness but identical EVs and variances, the animals preferred positively over symmetrical and negatively skewed gambles in a strongly transitive fashion. Thus, the utility functions predicted the animals' preferences for variance-risk and skewness-risk. Using these well-defined forms of risk, this study shows that monkeys' choices conform to the internal reward valuations suggested by their utility functions. This result implies a representation of utility in monkeys that accounts for both variance-risk and skewness-risk preferences.

  3. Spin Hall Effects Due to Phonon Skew Scattering

    NASA Astrophysics Data System (ADS)

    Gorini, Cosimo; Eckern, Ulrich; Raimondi, Roberto

    2015-08-01

    A diversity of spin Hall effects in metallic systems is known to rely on Mott skew scattering. In this work its high-temperature counterpart, phonon skew scattering, which is expected to be of foremost experimental relevance, is investigated. In particular, the phonon skew scattering spin Hall conductivity is found to be practically T independent for temperatures above the Debye temperature TD. As a consequence, in Rashba-like systems a high-T linear behavior of the spin Hall angle demonstrates the dominance of extrinsic spin-orbit scattering only if the intrinsic spin splitting is smaller than the temperature.

  4. PRINCIPLE OF SKEW QUADRUPOLE MODULATION TO MEASURE BETATRON COUPLING.

    SciTech Connect

    LUO.Y.PILAT,F.ROSER,T.ET AL.

    2004-07-05

    The measurement of the residual betatron coupling via skew quadrupole modulation is a new diagnostics technique that has been developed and tested at the Relativistic Heavy Ion Collider (RHIC) as a very promising method for the linear decoupling on the ramp. By modulating the strengths of different skew quadrupole families the two eigentunes are precisely measured with the phase lock loop system. The projections of the residual coupling coefficient onto the skew quadrupole coupling modulation directions are determined. The residual linear coupling could be corrected according to the measurement. An analytical solution for skew quadrupole modulation based on Hamiltonian perturbation approximation is given, and simulation code using smooth accelerator model is also developed. Some issues concerning the practical applications of this technique are discussed.

  5. 2. Skew Span on left to Span 3 on right ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Skew Span on left to Span 3 on right from north bank-up river. - Monongahela Connecting Railroad Company, Hot Metal Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  6. 4. From Skew Span to portal on span 1 looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. From Skew Span to portal on span 1 looking up grade toward the south end. - Monongahela Connecting Railroad Company, Hot Metal Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  7. 3. Span 4 on right to Skew Span on leftfrom ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Span 4 on right to Skew Span on left-from south bank-up river. - Monongahela Connecting Railroad Company, Hot Metal Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  8. Systems of Differential Equations with Skew-Symmetric, Orthogonal Matrices

    ERIC Educational Resources Information Center

    Glaister, P.

    2008-01-01

    The solution of a system of linear, inhomogeneous differential equations is discussed. The particular class considered is where the coefficient matrix is skew-symmetric and orthogonal, and where the forcing terms are sinusoidal. More general matrices are also considered.

  9. LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE (HAER No. PA-116). - Philadelphia & Reading Railroad, Reading Depot Bridge, North Sixth Street at Woodward Street, Reading, Berks County, PA

  10. 7. William E. Barrett, Photographer, 1974. SKEWED VIEW SHOWING CHEAT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. William E. Barrett, Photographer, 1974. SKEWED VIEW SHOWING CHEAT RIVER VALLEY, REMAINS OF 1887 PIER AND c. 1900 MASONRY ARCHES. - Baltimore & Ohio Railroad, Tray Run Viaduct, Spanning Tray Run, Rowlesburg, Preston County, WV

  11. Vibration of skewed cantilever plates and helicoidal shells

    NASA Technical Reports Server (NTRS)

    Beres, D. P.; Bailey, C. D.

    1975-01-01

    Theoretical vibration frequencies and mode shapes are obtained for skewed plates and helicoidal shells with a cantilever boundary. Using Hamilton's law of varying action, a power series solution is developed to obtain converged numerical results for the five lowest frequencies. Effects of geometrical variables such as aspect ratio, sweep angle and shell radius to thickness ratio are investigated. Accuracy of the solution method is substantiated by comparison with existing skewed plate spherical cap, and conical shell results.

  12. Flow in Rotating Serpentine Coolant Passages With Skewed Trip Strips

    NASA Technical Reports Server (NTRS)

    Tse, David G.N.; Steuber, Gary

    1996-01-01

    Laser velocimetry was utilized to map the velocity field in serpentine turbine blade cooling passages with skewed trip strips. The measurements were obtained at Reynolds and Rotation numbers of 25,000 and 0.24 to assess the influence of trips, passage curvature and Coriolis force on the flow field. The interaction of the secondary flows induced by skewed trips with the passage rotation produces a swirling vortex and a corner recirculation zone. With trips skewed at +45 deg, the secondary flows remain unaltered as the cross-flow proceeds from the passage to the turn. However, the flow characteristics at these locations differ when trips are skewed at -45 deg. Changes in the flow structure are expected to augment heat transfer, in agreement with the heat transfer measurements of Johnson, et al. The present results show that trips are skewed at -45 deg in the outward flow passage and trips are skewed at +45 deg in the inward flow passage maximize heat transfer. Details of the present measurements were related to the heat transfer measurements of Johnson, et al. to relate fluid flow and heat transfer measurements.

  13. Sample skewness as a statistical measurement of neuronal tuning sharpness.

    PubMed

    Samonds, Jason M; Potetz, Brian R; Lee, Tai Sing

    2014-05-01

    We propose using the statistical measurement of the sample skewness of the distribution of mean firing rates of a tuning curve to quantify sharpness of tuning. For some features, like binocular disparity, tuning curves are best described by relatively complex and sometimes diverse functions, making it difficult to quantify sharpness with a single function and parameter. Skewness provides a robust nonparametric measure of tuning curve sharpness that is invariant with respect to the mean and variance of the tuning curve and is straightforward to apply to a wide range of tuning, including simple orientation tuning curves and complex object tuning curves that often cannot even be described parametrically. Because skewness does not depend on a specific model or function of tuning, it is especially appealing to cases of sharpening where recurrent interactions among neurons produce sharper tuning curves that deviate in a complex manner from the feedforward function of tuning. Since tuning curves for all neurons are not typically well described by a single parametric function, this model independence additionally allows skewness to be applied to all recorded neurons, maximizing the statistical power of a set of data. We also compare skewness with other nonparametric measures of tuning curve sharpness and selectivity. Compared to these other nonparametric measures tested, skewness is best used for capturing the sharpness of multimodal tuning curves defined by narrow peaks (maximum) and broad valleys (minima). Finally, we provide a more formal definition of sharpness using a shape-based information gain measure and derive and show that skewness is correlated with this definition.

  14. Quantum Fisher and skew information for Unruh accelerated Dirac qubit

    NASA Astrophysics Data System (ADS)

    Banerjee, Subhashish; Alok, Ashutosh Kumar; Omkar, S.

    2016-08-01

    We develop a Bloch vector representation of the Unruh channel for a Dirac field mode. This is used to provide a unified, analytical treatment of quantum Fisher and skew information for a qubit subjected to the Unruh channel, both in its pure form as well as in the presence of experimentally relevant external noise channels. The time evolution of Fisher and skew information is studied along with the impact of external environment parameters such as temperature and squeezing. The external noises are modelled by both purely dephasing phase damping and the squeezed generalised amplitude damping channels. An interesting interplay between the external reservoir temperature and squeezing on the Fisher and skew information is observed, in particular, for the action of the squeezed generalised amplitude damping channel. It is seen that for some regimes, squeezing can enhance the quantum information against the deteriorating influence of the ambient environment. Similar features are also observed for the analogous study of skew information, highlighting a similar origin of the Fisher and skew information.

  15. Determining collective barrier operation skew in a parallel computer

    SciTech Connect

    Faraj, Daniel A.

    2015-11-24

    Determining collective barrier operation skew in a parallel computer that includes a number of compute nodes organized into an operational group includes: for each of the nodes until each node has been selected as a delayed node: selecting one of the nodes as a delayed node; entering, by each node other than the delayed node, a collective barrier operation; entering, after a delay by the delayed node, the collective barrier operation; receiving an exit signal from a root of the collective barrier operation; and measuring, for the delayed node, a barrier completion time. The barrier operation skew is calculated by: identifying, from the compute nodes' barrier completion times, a maximum barrier completion time and a minimum barrier completion time and calculating the barrier operation skew as the difference of the maximum and the minimum barrier completion time.

  16. OPERATIONAL MEASUREMENT OF COUPLING BY SKEW QUADRUPOLE MODULATION.

    SciTech Connect

    LUO.Y.CAMERON,P.LEE,R.ET AL.

    2004-07-05

    The measurement and correction of the residual betatron coupling via skew quadrupole modulation is a new diagnostics technique that has been developed and tested at the Relativistic Heavy Ion Collider (RHIC) as a very promising method for the linear decoupling on the ramp. By modulating the strengths of the skew quadrupole families the two eigentune modulations are precisely measured with a high resolution phase lock loop system. The projections of the residual coupling coefficient onto the skew quadrupole coupling modulation direction are determined. The residual linear coupling could be corrected according the measurement. We report the results from the dedicated beam studies carried on at RHIC injection, store and on the ramp. A capability of measuring coupling on the ramp opens possibility of continuous coupling corrections during acceleration.

  17. Uniqueness: skews bit occurrence frequencies in randomly generated fingerprint libraries.

    PubMed

    Chen, Nelson G

    2016-08-01

    Requiring that randomly generated chemical fingerprint libraries have unique fingerprints such that no two fingerprints are identical causes a systematic skew in bit occurrence frequencies, the proportion at which specified bits are set. Observed frequencies (O) at which each bit is set within the resulting libraries systematically differ from frequencies at which bits are set at fingerprint generation (E). Observed frequencies systematically skew toward 0.5, with the effect being more pronounced as library size approaches the compound space, which is the total number of unique possible fingerprints given the number of bit positions each fingerprint contains. The effect is quantified for varying library sizes as a fraction of the overall compound space, and for changes in the specified frequency E. The cause and implications for this systematic skew are subsequently discussed. When generating random libraries of chemical fingerprints, the imposition of a uniqueness requirement should either be avoided or taken into account.

  18. Bayesian partial linear model for skewed longitudinal data.

    PubMed

    Tang, Yuanyuan; Sinha, Debajyoti; Pati, Debdeep; Lipsitz, Stuart; Lipshultz, Steven

    2015-07-01

    Unlike majority of current statistical models and methods focusing on mean response for highly skewed longitudinal data, we present a novel model for such data accommodating a partially linear median regression function, a skewed error distribution and within subject association structures. We provide theoretical justifications for our methods including asymptotic properties of the posterior and associated semiparametric Bayesian estimators. We also provide simulation studies to investigate the finite sample properties of our methods. Several advantages of our method compared with existing methods are demonstrated via analysis of a cardiotoxicity study of children of HIV-infected mothers.

  19. Power and Skew Aware Point Diffusion Clock Network

    NASA Astrophysics Data System (ADS)

    Jung, Gunok; Kim, Chunghee; Chae, Kyoungkuk; Park, Giho; Park, Sung Bae

    This letter presents point diffusion clock network (PDCN) with local clock tree synthesis (CTS) scheme. The clock network is implemented with ten times wider metal line space than typical mesh networks for low power and utilized to nine times smaller area CTS execution for minimized clock skew amount. The measurement results show that skew amount of PDCN with local CTS is reduced to 36% and latency is shrunk to 45% of the amount in a 4.81mm2 CortexA-8 core with 65nm Samsung process.

  20. Skewness of steady-state current fluctuations in nonequilibrium systems.

    PubMed

    Belousov, Roman; Cohen, E G D; Wong, Chun-Shang; Goree, John A; Feng, Yan

    2016-04-01

    A skewness of the probability for instantaneous current fluctuations, in a nonequilibrium steady state, is observed experimentally in a dusty plasma. This skewness is attributed to the spatial asymmetry, which is imminent to the nonequilibrium systems due to the external hydrodynamic gradient. Using the modern framework of the large deviation theory, we extend the Onsager-Machlup ansatz for equilibrium fluctuations to systems with a preferred spatial direction, and provide a modulated Gaussian probability distribution, which is tested by simulations. This probability distribution is also of potential interest for other statistical disciplines. Connections with the principles of statistical mechanics, due to Boltzmann and Gibbs, are discussed as well. PMID:27176272

  1. On Optimal Backward Perturbation Analysis for the Linear System with Skew Circulant Coefficient Matrix

    PubMed Central

    Jiang, Zhaolin; Shen, Nuo; Zhou, Jianwei

    2013-01-01

    We first give the style spectral decomposition of a special skew circulant matrix C and then get the style decomposition of arbitrary skew circulant matrix by making use of the Kronecker products between the elements of first row in skew circulant and the special skew circulant C. Besides that, we obtain the singular value of skew circulant matrix as well. Finally, we deal with the optimal backward perturbation analysis for the linear system with skew circulant coefficient matrix on the base of its style spectral decomposition. PMID:24369488

  2. Thermocline Feedback Influence on Indian Ocean Dipole Skewness

    NASA Astrophysics Data System (ADS)

    Ng, B.; Cai, W.; Walsh, K. J.

    2014-12-01

    A positive Indian Ocean Dipole (IOD) tends to have stronger cold sea surface temperature anomalies (SSTAs) over the eastern Indian Ocean with greater impacts than warm SSTAs that occur during its negative phase. These impacts from positive IODs range from drought over Australia and Indonesia, to flooding over East Africa and India. Two feedbacks have been suggested as the cause of positive IOD skewness, a positive Bjerknes feedback and a negative SST-cloud-radiation (SCR) feedback, but their relative importance is debated. Using models from phase 5 of the Coupled Model Intercomparison Project (CMIP5) and inter-model statistics, we show that the most important process for IOD skewness is an asymmetry in the thermocline feedback, whereby SSTAs respond to thermocline depth anomalies more strongly during the positive phase than negative phase. This asymmetric thermocline feedback drives IOD skewness despite positive IODs receiving greater damping from the SCR feedback. In response to global warming, although the thermocline feedback strengthens, its asymmetry between positive and negative IODs weakens. This behaviour change explains the reduction in IOD skewness that many models display under global warming.

  3. Skewness and Comparability of School Based Continuous Assessment Scores

    ERIC Educational Resources Information Center

    Gbore, Lawrence Olu; Olabode, Abe Thomas; Olufemi, Adodo Sunday

    2011-01-01

    This study examined skewness as means of determining the nature of distribution of school based continuous assessment (SBCA) scores in selected subjects among Secondary Schools in Ondo State, Nigeria, to determine whether or not there is need for moderation of the SBCA Scores. This is an ex-post-facto research design involving no treatment and…

  4. 4. North portal of Skew Span looking south and leading ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. North portal of Skew Span looking south and leading to Span 1 Main Bridge on the left and Span 1 Hot Metal Bridge on the right. - Monongahela Connecting Railroad Company, Main Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  5. Root waving and skewing: unexpectedly in micro-g.

    PubMed

    Roux, Stanley J

    2012-12-07

    Gravity has major effects on both the form and overall length of root growth. Numerous papers have documented these effects (over 300 publications in the last 5 years), the most well-studied being gravitropism, which is a growth re-orientation directed by gravity toward the earth's center. Less studied effects of gravity are undulations due to the regular periodic change in the direction root tips grow, called waving, and the slanted angle of growth roots exhibit when they are growing along a nearly-vertical surface, called skewing. Although diverse studies have led to the conclusion that a gravity stimulus is needed for plant roots to show waving and skewing, the novel results just published by Paul et al. (2012) reveal that this conclusion is not correct. In studies carried out in microgravity on the International Space Station, the authors used a new imaging system to collect digital photographs of plants every six hours during 15 days of spaceflight. The imaging system allowed them to observe how roots grew when their orientation was directed not by gravity but by overhead LED lights, which roots grew away from because they are negatively phototropic. Surprisingly, the authors observed both skewing and waving in spaceflight plants, thus demonstrating that both growth phenomena were gravity independent. Touch responses and differential auxin transport would be common features of root waving and skewing at 1-g and micro-g, and the novel results of Paul et al. will focus the attention of cell and molecular biologists more on these features as they try to decipher the signaling pathways that regulate root skewing and waving.

  6. Arc voltage distribution skewness as an indicator of electrode gap during vacuum arc remelting

    DOEpatents

    Williamson, Rodney L.; Zanner, Frank J.; Grose, Stephen M.

    1998-01-01

    The electrode gap of a VAR is monitored by determining the skewness of a distribution of gap voltage measurements. A decrease in skewness indicates an increase in gap and may be used to control the gap.

  7. Correcting Quadrupole Roll in Magnetic Lenses with Skew Quadrupoles

    SciTech Connect

    Walstrom, Peter Lowell

    2014-11-10

    Quadrupole rolls (i.e. rotation around the magnet axis) are known to be a significant source of image blurring in magnetic quadrupole lenses. These rolls may be caused by errors in mechanical mounting of quadrupoles, by uneven radiation-induced demagnetization of permanent-magnet quadrupoles, etc. Here a four-quadrupole ×10 lens with so-called ”Russian” or A -B B-A symmetry is used as a model problem. Existing SLAC 1/2 in. bore high-gradient quadrupoles are used in the design. The dominant quadrupole roll effect is changes in the first-order part of the transfer map (the R matrix) from the object to the image plane (Note effects on the R matrix can be of first order in rotation angle for some R-matrix elements and second order in rotation angle for other elements, as shown below). It is possible to correct roll-induced image blur by mechanically adjusting the roll angle of one or more of the quadrupoles. Usually, rotation of one quadrupole is sufficient to correct most of the combined effect of rolls in all four quadrupoles. There are drawbacks to this approach, however, since mechanical roll correction requires multiple entries into experimental area to make the adjustments, which are made according to their effect on images. An alternative is to use a single electromagnetic skew quadrupole corrector placed either between two of the quadrupoles or after the fourth quadrupole (so-called “non-local” correction). The basic feasibility of skew quadrupole correction of quadrupole roll effects is demonstrated here. Rolls of the third lens quadrupole of up to about 1 milliradian can be corrected with a 15 cm long skew quadrupole with a gradient of up to 1 T/m. Since the effect of rolls of the remaining three lens quadrupoles are lower, a weaker skew quadrupole can be used to correct them. Non-local correction of quadrupole roll effects by skew quadrupoles is shown to be about one-half as effective as local correction (i.e. rotating individual quadrupoles to zero

  8. Skewed Brownian Fluctuations in Single-Molecule Magnetic Tweezers

    PubMed Central

    Burnham, Daniel R.; De Vlaminck, Iwijn; Henighan, Thomas; Dekker, Cees

    2014-01-01

    Measurements in magnetic tweezers rely upon precise determination of the position of a magnetic microsphere. Fluctuations in the position due to Brownian motion allows calculation of the applied force, enabling deduction of the force-extension response function for a single DNA molecule that is attached to the microsphere. The standard approach relies upon using the mean of position fluctuations, which is valid when the microsphere axial position fluctuations obey a normal distribution. However, here we demonstrate that nearby surfaces and the non-linear elasticity of DNA can skew the distribution. Through experiment and simulations, we show that such a skewing leads to inaccurate position measurements which significantly affect the extracted DNA extension and mechanical properties, leading to up to two-fold errors in measured DNA persistence length. We develop a simple, robust and easily implemented method to correct for such mismeasurements. PMID:25265383

  9. SKEW QUADRUPOLES IN RHIC DIPOLE MAGNETS AT HIGH FIELDS.

    SciTech Connect

    JAIN, A.; GUPTA, P.; THOMPSON, P.; WANDERER, P.

    1995-06-11

    In the RHIC arc dipoles, the center of the cold mass lies above the center of the cryostat. At the maximum design field, the magnetic flux lines leak through the yoke to the asymmetrically located cryostat, which provides an additional return path. This introduces a systematic top-bottom asymmetry leading to a skew quadrupole term at high fields. A similar asymmetry is also created by any difference in weights of the upper and the lower yoke halves. Data from measurements of several RHIC dipoles are presented to study this effect. In the current production series of the RDIC dipoles, an attempt is made to compensate the effect of the cryostat by an asymmetry in the iron yoke. Seven dipoles with this type of yoke have been cold tested, and show a reduced saturation in the skew quadrupole term, as expected.

  10. Quantifying Correlations via the Wigner-Yanase-Dyson Skew Information

    NASA Astrophysics Data System (ADS)

    Fan, Yajing; Cao, Huaixin

    2016-09-01

    In this paper, based on a discussion about the Wigner-Yanase-Dyson (WYD) skew information, the measure F a, α ( ρ a b ) for correlations in terms of the WYD skew information is introduced and discussed. The following conclusions are obtained. For a classical-quantum state ρ a b , F a, α ( ρ a b )=0 if and only if ρ a b is a product state; F a, α ( ρ a b ) is locally unitary invariant and convex on the set of states with the fixed marginal ρ a ; F a, α ( ρ a b ) decreases under local random unitary operation on H b ; For a quantum-classical state ρ a b , F a, α ( ρ a b ) decreases under local operation on H b ; Lastly, F a, α ( ρ a b ) is computed for the pure states and the Bell-diagonal states, respectively.

  11. Identification of spots in rotated and skewed microarray images

    NASA Astrophysics Data System (ADS)

    Le Brese, Christopher; Zou, Ju Jia

    2009-12-01

    DNA microarray image processing has vast potential in the measurement of mass gene expression. A common approach to processing microarrays consists of spot identification, spot segmentation, and information extraction. We are concerned with spot identification. We aim to tackle the problem of identifying spots in rotated and skewed arrays via an automated process. The method proposed is composed of three steps, namely, array orientation calculation based on the Hough transform, affine calculation and correction, and gridding. The method is able to correctly identify spots in a microarray that has been rotated or skewed at an angle between 0 and +/-30 deg and corrupted by various types of noise such as high-intensity streaks, Gaussian noise, and salt-and-pepper noise.

  12. Free vibration analyses of generally laminated tapered skew plates

    NASA Astrophysics Data System (ADS)

    Kapania, Rakesh K.; Singhvi, Sarvesh

    1992-04-01

    An efficient method is developed for the free vibration analyses of generally laminated composite skew plates having arbitrary edge conditions, such as clamped, simply supported or free. The procedure consists of the Rayleigh-Ritz method utilizing a strain energy functional containing both bending and stretching effects and accommodating arbitrary ply stacking sequences. A set of Chebyshev polynomials is used as trial functions to represent the three components of the displacement at a given point. The geometric boundary conditions are satisfied by providing appropriate springs with large stiffnesses at a given edge. Results are obtained for isotropic, specially orthotropic, symmetrically laminated and unsymmetrically laminated plates. Both rectangular and skewed tapered plates are analyzed. The capability to perform the static analysis of a composite plate is also demonstrated. To establish the correctness and effectiveness of the method, whenever possible, the numerical results are compared with those obtained by other researchers.

  13. Universal relation between skewness and kurtosis in complex dynamics

    NASA Astrophysics Data System (ADS)

    Cristelli, Matthieu; Zaccaria, Andrea; Pietronero, Luciano

    2012-06-01

    We identify an important correlation between skewness and kurtosis for a broad class of complex dynamic systems and present a specific analysis of earthquake and financial time series. Two regimes of non-Gaussianity can be identified: a parabolic one, which is common in various fields of physics, and a power law one, with exponent 4/3, which at the moment appears to be specific of earthquakes and financial markets. For this property we propose a model and an interpretation in terms of very rare events dominating the statistics independently on the nature of the events considered. The predicted scaling relation between skewness and kurtosis matches very well the experimental pattern of the second regime. Regarding price fluctuations, this situation characterizes a universal stylized fact.

  14. Incorporating Skew into RMS Surface Roughness Probability Distribution

    NASA Technical Reports Server (NTRS)

    Stahl, Mark T.; Stahl, H. Philip.

    2013-01-01

    The standard treatment of RMS surface roughness data is the application of a Gaussian probability distribution. This handling of surface roughness ignores the skew present in the surface and overestimates the most probable RMS of the surface, the mode. Using experimental data we confirm the Gaussian distribution overestimates the mode and application of an asymmetric distribution provides a better fit. Implementing the proposed asymmetric distribution into the optical manufacturing process would reduce the polishing time required to meet surface roughness specifications.

  15. Skew and twist resistant hydrodynamic rotary shaft seal

    DOEpatents

    Dietle, Lannie; Kalsi, Manmohan Singh

    1999-01-01

    A hydrodynamically lubricated squeeze packing type rotary shaft seal suitable for lubricant retention and environmental exclusion which incorporates one or more resilient protuberances which and cooperate with the gland walls to hold the seal straight in its installation groove in unpressurized and low pressure lubricant retention applications thereby preventing skew-induced wear caused by impingement of abrasive contaminants present in the environment, and which also serve as radial bearings to prevent tipping of the seal within its installation gland.

  16. Skew and twist resistant hydrodynamic rotary shaft seal

    DOEpatents

    Dietle, L.; Kalsi, M.S.

    1999-02-23

    A hydrodynamically lubricated squeeze packing type rotary shaft seal suitable for lubricant retention and environmental exclusion which incorporates one or more resilient protuberances which cooperate with the gland walls to hold the seal straight in its installation groove in unpressurized and low pressure lubricant retention applications thereby preventing skew-induced wear caused by impingement of abrasive contaminants present in the environment, and which also serve as radial bearings to prevent tipping of the seal within its installation gland. 14 figs.

  17. MEASURING LOCAL GRADIENT AND SKEW QUADRUPOLE ERRORS IN RHIC IRS.

    SciTech Connect

    CARDONA,J.; PEGGS,S.; PILAT,R.; PTITSYN,V.

    2004-07-05

    The measurement of local linear errors at RHIC interaction regions using an ''action and phase'' analysis of difference orbits has already been presented. This paper evaluates the accuracy of this technique using difference orbits that were taken when known gradient errors and skew quadrupole errors were intentionally introduced. It also presents action and phase analysis of simulated orbits when controlled errors are intentionally placed in a RHIC simulation model.

  18. Kurtosis, skewness, and non-Gaussian cosmological density perturbations

    NASA Technical Reports Server (NTRS)

    Luo, Xiaochun; Schramm, David N.

    1993-01-01

    Cosmological topological defects as well as some nonstandard inflation models can give rise to non-Gaussian density perturbations. Skewness and kurtosis are the third and fourth moments that measure the deviation of a distribution from a Gaussian. Measurement of these moments for the cosmological density field and for the microwave background temperature anisotropy can provide a test of the Gaussian nature of the primordial fluctuation spectrum. In the case of the density field, the importance of measuring the kurtosis is stressed since it will be preserved through the weakly nonlinear gravitational evolution epoch. Current constraints on skewness and kurtosis of primeval perturbations are obtained from the observed density contrast on small scales and from recent COBE observations of temperature anisotropies on large scales. It is also shown how, in principle, future microwave anisotropy experiments might be able to reveal the initial skewness and kurtosis. It is shown that present data argue that if the initial spectrum is adiabatic, then it is probably Gaussian, but non-Gaussian isocurvature fluctuations are still allowed, and these are what topological defects provide.

  19. Caste load and the evolution of reproductive skew.

    PubMed

    Holman, Luke

    2014-01-01

    Reproductive skew theory seeks to explain how reproduction is divided among group members in animal societies. Existing theory is framed almost entirely in terms of selection, though nonadaptive processes must also play some role in the evolution of reproductive skew. Here I propose that a genetic correlation between helper fecundity and breeder fecundity may frequently constrain the evolution of reproductive skew. This constraint is part of a wider phenomenon that I term "caste load," which is defined as the decline in mean fitness caused by caste-specific selection pressures, that is, differential selection on breeding and nonbreeding individuals. I elaborate the caste load hypothesis using quantitative and population genetic arguments and individual-based simulations. Although selection can sometimes erode genetic correlations and resolve caste load, this may be constrained when mutations have similar pleiotropic effects on breeder and helper traits. I document evidence for caste load, identify putative genomic adaptations to it, and suggest future research directions. The models highlight the value of considering adaptation within the boundaries imposed by genetic architecture and incidentally reaffirm that monogamy promotes the evolutionary transition to eusociality. PMID:24334738

  20. Validation of an Acoustic Impedance Prediction Model for Skewed Resonators

    NASA Technical Reports Server (NTRS)

    Howerton, Brian M.; Parrott, Tony L.

    2009-01-01

    An impedance prediction model was validated experimentally to determine the composite impedance of a series of high-aspect ratio slot resonators incorporating channel skew and sharp bends. Such structures are useful for packaging acoustic liners into constrained spaces for turbofan noise control applications. A formulation of the Zwikker-Kosten Transmission Line (ZKTL) model, incorporating the Richards correction for rectangular channels, is used to calculate the composite normalized impedance of a series of six multi-slot resonator arrays with constant channel length. Experimentally, acoustic data was acquired in the NASA Langley Normal Incidence Tube over the frequency range of 500 to 3500 Hz at 120 and 140 dB OASPL. Normalized impedance was reduced using the Two-Microphone Method for the various combinations of channel skew and sharp 90o and 180o bends. Results show that the presence of skew and/or sharp bends does not significantly alter the impedance of a slot resonator as compared to a straight resonator of the same total channel length. ZKTL predicts the impedance of such resonators very well over the frequency range of interest. The model can be used to design arrays of slot resonators that can be packaged into complex geometries heretofore unsuitable for effective acoustic treatment.

  1. Tide and skew surge independence: New insights for flood risk

    NASA Astrophysics Data System (ADS)

    Williams, Joanne; Horsburgh, Kevin J.; Williams, Jane A.; Proctor, Robert N. F.

    2016-06-01

    Storm surges are a significant hazard to coastal communities around the world, putting lives at risk and costing billions of dollars in damage. Understanding how storm surges and high tides interact is crucial for estimating extreme water levels so that we can protect coastal communities. We demonstrate that in a tidal regime the best measure of a storm surge is the skew surge, the difference between the observed and predicted high water within a tidal cycle. Based on tide gauge records spanning decades from the UK, U.S., Netherlands, and Ireland we show that the magnitude of high water exerts no influence on the size of the most extreme skew surges. This is the first systematic proof that any storm surge can occur on any tide, which is essential for understanding worst-case scenarios. The lack of surge generation dependency on water depth emphasizes the dominant natural variability of weather systems in an observation-based analysis. Weak seasonal relationships between skew surges and high waters were identified at a minority of locations where long-period changes to the tidal cycle interact with the storm season. Our results allow advances to be made in methods for estimating the joint probabilities of storm surges and tides.

  2. Skew And Twist Resistant Hydrodynamic Rotary Shaft Seal

    DOEpatents

    Dietle, Lannie; Kalsi, Manmohan Singh

    2000-03-14

    A hydrodynamically lubricated squeeze packing type rotary shaft seal suitable for lubricant retention and environmental exclusion which incorporates one or more resilient protuberances which and cooperate with the gland walls to hold the seal straight in its installation groove in unpressurized and low pressure lubricant retention applications thereby preventing skew-induced wear caused by impingement of abrasive contaminants present in the environment, and which also serve as radial bearings to prevent tipping of the seal within its installation gland. Compared to prior art, this invention provides a dramatic reduction of seal and shaft wear in abrasive environments and provides a significant increase in seal life.

  3. Light transmission for polymer fibers using skew and meridional rays

    NASA Astrophysics Data System (ADS)

    Tekelioglu, Murat

    This dissertation is concerned with the development of a light transmission model for polymer optical fibers having application in hybrid solar lighting (HSL) systems. Conceptually, the HSL system consists of a solar collector/receiver that focuses concentrated visible solar light onto a polymer optical fiber (up to 10-m-long) that transports the solar light to an interior space. For this study, the polymer optical fiber is a large-core (0.2-40 mm diameter) plastic optical fiber (POF) comprised of various lengths of straight and bent sections. Although there has been extensive research on the transmission of monochromatic light through optical fibers for the communications industry, there are relatively few publications for visible light transmission through POFs. These publications were critically reviewed in this research. It is shown that the light transmission can be described with either skew or meridional rays. For each ray type, the HSL system light transmission was determined as a function of fiber geometrical properties (core and cladding radii, bend radius, bend angle, and fiber length) and optical properties (core and clad refractive indices, absorption and scattering coefficients, core-clad rms roughness height, and core-clad interface defects loss coefficient). To do this, first, models were developed for separate straight and bent sections for multiple skew and meridional rays. Second, the straight and bent models were combined into a FORTRAN simulation program for an arbitrary fiber with a combination of arbitrary straight and bent sections. The input condition of the rays (arrangement of rays, incident angle, and intensity profile) is user-defined. Third, the simulation results were experimentally validated using two different POFs, twelve configurations of straight and bent fiber subsystems, and two ray types. These experimental comparisons show that the transmission model using meridional rays is slightly better than that with the skew rays. But

  4. Wigner-Yanase skew information as tests for quantum entanglement

    SciTech Connect

    Chen Zeqian

    2005-05-15

    A Bell-type inequality is proposed in terms of Wigner-Yanase skew information, which is quadratic and involves only one local spin observable at each site. This inequality presents a hierarchic classification of all states of multipartite quantum systems from separable to fully entangled states, which is more powerful than the one presented by quadratic Bell inequalities from two-entangled to fully entangled states. In particular, it is proved that the inequality provides an exact test to distinguish entangled from nonentangled pure states of two qubits. Our inequality sheds considerable light on relationships between quantum entanglement and information theory.

  5. Effect of Resonator Axis Skew on Normal Incidence Impedance

    NASA Technical Reports Server (NTRS)

    Parrott, Tony L.; Jones, Michael G.; Homeijer, Brian

    2003-01-01

    High by-pass turbofan engines have fewer fan blades and lower rotation speeds than their predecessors. Consequently, the noise suppression at the low frequency end of the noise spectra has become an increasing concern. This has led to a renewed emphasis on improving noise suppression efficiency of passive, duct liner treatments at the lower frequencies. For a variety of reasons, passive liners are comprised of locally-reacting, resonant absorbers. One reason for this design choice is to satisfy operational and economic requirements. The simplest liner design consists of a single layer of honeycomb core sandwiched between a porous facesheet and an impervious backing plate. These resonant absorbing structures are integrated into the nacelle wall and are very ef- ficient over a limited bandwidth centered on their resonance frequency. Increased noise suppression bandwidth and greater suppression at lower frequencies is typically achieved for conventional liners by increasing the liner depth and incorporating thin porous septa into the honeycomb core. However, constraints on liner depth in modern high by-pass engine nacelles severely limit the suppression bandwidth extension to lower frequencies. Also, current honeycomb core liners may not be suitable for irregular geometric volumes heretofore not considered. It is of interest, therefore, to find ways to circumvent liner depth restrictions and resonator cavity shape constraints. One way to increase effective liner depth is to skew the honeycomb core axis relative to the porous facesheet surface. Other possibilities are to alter resonator cavity shape, e.g. high aspect ratio, narrow channels that possibly include right angle bends, 180. channel fold-backs, and splayed channel walls to conform to irregular geometric constraints. These possibilities constitute the practical motivation for expanding impedance modeling capability to include unconventional resonator orientations and shapes. The work reported in this paper is

  6. Pattern formation of underwater sand ripples with a skewed drive.

    PubMed

    Bundgaard, F; Ellegaard, C; Scheibye-Knudsen, K; Bohr, T; Sams, T

    2004-12-01

    In this paper we present an experimental study of the dynamics of underwater sand ripples when a regular pattern of ripples is subjected to a skewed oscillatory flow, i.e., one not perpendicular to the direction of the ripple crests. Striking patterns with new, superposed ripples on top of the original ones occur very quickly with a characteristic angle, which is, in general, not perpendicular to the flow. A slower, more complex transition then follows, leading to the final state where the ripples are again perpendicular to the flow. We investigate the variation of the superposed pattern as a function of the direction, amplitude, and frequency of the drive, and as a function of the viscosity (by changing the temperature). We quantify the dynamics of the entire transition process and finally study the grain motion around idealized (solid) skewed ripples. This leads to a characteristic mean path of a single particle. The path has a shape close to a parallelogram, with no apparent connection to the pattern of real, superposed ripples. On the other hand, a thin layer of sand sprinkled on the solid ripples leads to qualitatively similar patterns.

  7. Characterising Uncertainty in Expert Assessments: Encoding Heavily Skewed Judgements

    PubMed Central

    O’Leary, Rebecca A.; Low-Choy, Samantha; Fisher, Rebecca; Mengersen, Kerrie; Caley, M. Julian

    2015-01-01

    When limited or no observed data are available, it is often useful to obtain expert knowledge about parameters of interest, including point estimates and the uncertainty around these values. However, it is vital to elicit this information appropriately in order to obtain valid estimates. This is particularly important when the experts’ uncertainty about these estimates is strongly skewed, for instance when their best estimate is the same as the lowest value they consider possible. Also this is important when interest is in the aggregation of elicited values. In this paper, we compare alternative distributions for describing such estimates. The distributions considered include the lognormal, mirror lognormal, Normal and scaled Beta. The case study presented here involves estimation of the number of species in coral reefs, which requires eliciting counts within broader taxonomic groups, with highly skewed uncertainty estimates. This paper shows substantial gain in using the scaled Beta distribution, compared with Normal or lognormal distributions. We demonstrate that, for this case study on counting species, applying the novel encoding methodology developed in this paper can facilitate the acquisition of more rigorous estimates of (hierarchical) count data and credible bounds. The approach can also be applied to the more general case of enumerating a sampling frame via elicitation. PMID:26517835

  8. Multiple mating and reproductive skew in Trinidadian guppies.

    PubMed Central

    Becher, S. A.; Magurran, A. E.

    2004-01-01

    Male offspring production in promiscuously mating species is typically more skewed than female offspring production. It is therefore advantageous for males to seek as many mating partners as possible. However, given the documented benefits of polyandry we expect females, as well as males, to mate multiply. We tested these ideas using Trinidadian guppies, Poecilia reticulata. Fishes were collected from the wild, housed in groups of 10 males and 10 females and allowed to reproduce freely over a period of three months. We used hypervariable microsatellite loci to identify the parents of 840 offspring and to quantify the variance in mating success. As anticipated, and in line with the Bateman gradient, there was greater skew in the number of progeny produced by males. By contrast, we found no sex difference in mating partner number over the duration of the experiment. A median of two males fathered each brood and there was marked turnover in the identities of the sires of successive broods. Female partner turnover was, however, less than expected under random mating. We suggest that partner switching over time, as well as polyandry within broods, could contribute to the maintenance of genetic diversity in guppy populations. PMID:15293853

  9. Crossover ensembles of random matrices and skew-orthogonal polynomials

    SciTech Connect

    Kumar, Santosh; Pandey, Akhilesh

    2011-08-15

    Highlights: > We study crossover ensembles of Jacobi family of random matrices. > We consider correlations for orthogonal-unitary and symplectic-unitary crossovers. > We use the method of skew-orthogonal polynomials and quaternion determinants. > We prove universality of spectral correlations in crossover ensembles. > We discuss applications to quantum conductance and communication theory problems. - Abstract: In a recent paper (S. Kumar, A. Pandey, Phys. Rev. E, 79, 2009, p. 026211) we considered Jacobi family (including Laguerre and Gaussian cases) of random matrix ensembles and reported exact solutions of crossover problems involving time-reversal symmetry breaking. In the present paper we give details of the work. We start with Dyson's Brownian motion description of random matrix ensembles and obtain universal hierarchic relations among the unfolded correlation functions. For arbitrary dimensions we derive the joint probability density (jpd) of eigenvalues for all transitions leading to unitary ensembles as equilibrium ensembles. We focus on the orthogonal-unitary and symplectic-unitary crossovers and give generic expressions for jpd of eigenvalues, two-point kernels and n-level correlation functions. This involves generalization of the theory of skew-orthogonal polynomials to crossover ensembles. We also consider crossovers in the circular ensembles to show the generality of our method. In the large dimensionality limit, correlations in spectra with arbitrary initial density are shown to be universal when expressed in terms of a rescaled symmetry breaking parameter. Applications of our crossover results to communication theory and quantum conductance problems are also briefly discussed.

  10. Experimental and finite element studies on free vibration of skew plates

    NASA Astrophysics Data System (ADS)

    Srinivasa, C. V.; Suresh, Y. J.; Prema Kumar, W. P.

    2014-03-01

    The present paper deals with the experimental and finite element studies carried out on free vibration of isotropic and laminated composite skew plates. The natural frequencies were determined using CQUAD8 finite element of MSC/NASTRAN and comparison made between the experimental values and the finite element solution. The effects of the skew angle and aspect ratio on the natural frequencies of isotropic skew plates were studied. The effects of skew angle, aspect ratio, fiber orientation angle and laminate stacking sequence (keeping total number of layers in the laminate constant) on the natural frequencies of antisymmetric laminated composite skew plates were also studied. The experimental values of the natural frequencies are in good agreement with the finite element solution. The natural frequencies generally increase with an increase in the skew angle for any given value of aspect ratio.

  11. Skew-normal/independent linear mixed models for censored responses with applications to HIV viral loads

    PubMed Central

    Bandyopadhyay, Dipankar; Lachos, Victor H.; Castro, Luis M.; Dey, Dipak K.

    2012-01-01

    Often in biomedical studies, the routine use of linear mixed-effects models (based on Gaussian assumptions) can be questionable when the longitudinal responses are skewed in nature. Skew-normal/elliptical models are widely used in those situations. Often, those skewed responses might also be subjected to some upper and lower quantification limits (viz. longitudinal viral load measures in HIV studies), beyond which they are not measurable. In this paper, we develop a Bayesian analysis of censored linear mixed models replacing the Gaussian assumptions with skew-normal/independent (SNI) distributions. The SNI is an attractive class of asymmetric heavy-tailed distributions that includes the skew-normal, the skew-t, skew-slash and the skew-contaminated normal distributions as special cases. The proposed model provides flexibility in capturing the effects of skewness and heavy tail for responses which are either left- or right-censored. For our analysis, we adopt a Bayesian framework and develop a MCMC algorithm to carry out the posterior analyses. The marginal likelihood is tractable, and utilized to compute not only some Bayesian model selection measures but also case-deletion influence diagnostics based on the Kullback-Leibler divergence. The newly developed procedures are illustrated with a simulation study as well as a HIV case study involving analysis of longitudinal viral loads. PMID:22685005

  12. Binomial Markov-Switching Multifractal model with Skewed t innovations and applications to Chinese SSEC Index

    NASA Astrophysics Data System (ADS)

    Liu, Yufang; Zhang, Weiguo; Fu, Junhui

    2016-11-01

    This paper presents the Binomial Markov-switching Multifractal (BMSM) model of asset returns with Skewed t innovations (BMSM-Skewed t for short), which considers the fat tails, skewness and multifractality in asset returns simultaneously. The parameters of BMSM-Skewed t model can be estimated by Maximum Likelihood (ML) methods, and volatility forecasting can be accomplished via Bayesian updating. In order to evaluate the performance of BMSM-Skewed t model, BMSM model with Normal innovations (BMSM-N), BMSM model with Student-t innovations (BMSM-t) and GARCH(1,1) models (GARCH-N, GARCH-t and GARCH-Skewed t) are chosen for comparison. Through empirical studies on Shanghai Stock Exchange Composite Index (SSEC), we find that for sample estimation, BMSM models outperform the GARCH(1,1) models through BIC and AIC rules, and BMSM-Skewed t performs the best among all the models due to its fat tails, skewness and multifractality. In addition, BMSM-Skewed t model dominates other models at most forecasting horizons for out-of-sample volatility forecasts in terms of MSE, MAE and SPA test.

  13. Skewness and shock formation in laboratory-scale supersonic jet data.

    PubMed

    Gee, Kent L; Neilsen, Tracianne B; Atchley, Anthony A

    2013-06-01

    Spatial properties of noise statistics near unheated, laboratory-scale supersonic jets yield insights into source characteristics and near-field shock formation. Primary findings are (1) waveforms with positive pressure skewness radiate from the source with a directivity upstream of maximum overall level and (2) skewness of the time derivative of the pressure waveforms increases significantly with range, indicating formation of shocks during propagation. These results corroborate findings of a previous study involving full-scale engine data. Further, a comparison of ideally and over-expanded laboratory data show that while derivative skewness maps are similar, waveform skewness maps are substantially different for the two cases. PMID:23742445

  14. Demographic corrections appear to compromise classification accuracy for severely skewed cognitive tests.

    PubMed

    O'Connell, Megan E; Tuokko, Holly; Kadlec, Helena

    2011-04-01

    Demographic corrections for cognitive tests should improve classification accuracy by reducing age or education biases, but empirical support has been equivocal. Using a simulation procedure, we show that creating moderate or extreme skewness in cognitive tests compromises the classification accuracy of demographic corrections, findings that appear replicated within clinical data for the few neuropsychological test scores with an extreme degree of skew. For most neuropsychological tests, the dementia classification accuracy of raw and demographically corrected scores was equivalent. These findings suggest that the dementia classification accuracy of demographic corrections is robust to slight degrees of skew (i.e., skewness <1.5). PMID:21154077

  15. COMPENSATION OF FAST KICKER ROLLS WITH SKEW QUADRUPOLES

    SciTech Connect

    Pinayev, I.

    2011-03-28

    The development of the third generation light sources lead to the implementation of the top-up operation, when injection occurs while users collect data. The beam excursions due to the non-closure of the injection bump can spoil the data and need to be suppressed. In the horizontal plane compensation can be achieved by adjusting timing and kick amplitudes. The rolls of the kicker magnets create non-closure in the vertical plane and usually there is no means for correction. In the paper we describe proposed compensation scheme utilizing two skew quadrupoles placed inside the injection bump. The third generation light sources implement top-up operation firstly introduced at Advanced Photon Source. In this mode the circulating beam current is supported near constant by frequent injection of small charge, while photon beam is delivered for users. The beam perturbations caused by the mismatched injection bump can provide undesired noise in the user data. Usually the injection trigger is distributed to the users end stations so that those affected would be able to blank data acquisition. Nevertheless, as good operational practice such transients should be suppressed as much as possible. In the horizontal plane (which is commonly used for injection) one can adjust individual kicker strength as well as trigger delay while observing motion of the stored beam centroid. In the vertical plane such means are unavailable in the most cases. The possible solutions include dedicated weak vertical kickers and motorized adjustment of the roll angle of the injection kickers. Both abovementioned approaches are expensive and can significantly deteriorate reliability. We suggest two employ two skew quadrupoles (to correct both angle and position) placed inside the injection bump. In this case the beam position itself serves as measure of the kicker strength (assuming that kickers are well matched) and vertical kicks from the skew quadrupoles will be self synchronized with injection bump

  16. Cracked shells under skew-symmetric loading. [Reissner theory

    NASA Technical Reports Server (NTRS)

    Delale, F.

    1981-01-01

    The general problem of a shell containing a through crack in one of the principal planes of curvature and under general skew-symmetric loading is considered. By employing a Reissner type shell theory which takes into account the effect of transverse shear strains, all boundary conditions on the crack surfaces are satisfied separately. Consequently, unlike those obtained from the classical shell theory, the angular distributions of the stress components around the crack tips are shown to be identical to the distributions obtained from the plane and anti-plane elasticity solutions. Results are given for axially and circumferentially cracked cylindrical shells, spherical shells, and toroidal shells under uniform in-plane shearing, out of plane shearing, and torsion. The problem is formulated for specially orthostropic materials, therefore, the effect of orthotropy on the results is also studied.

  17. Soft bounds on diffusion produce skewed distributions and Gompertz growth.

    PubMed

    Mandrà, Salvatore; Lagomarsino, Marco Cosentino; Gherardi, Marco

    2014-09-01

    Constraints can affect dramatically the behavior of diffusion processes. Recently, we analyzed a natural and a technological system and reported that they perform diffusion-like discrete steps displaying a peculiar constraint, whereby the increments of the diffusing variable are subject to configuration-dependent bounds. This work explores theoretically some of the revealing landmarks of such phenomenology, termed "soft bound." At long times, the system reaches a steady state irreversibly (i.e., violating detailed balance), characterized by a skewed "shoulder" in the density distribution, and by a net local probability flux, which has entropic origin. The largest point in the support of the distribution follows a saturating dynamics, expressed by the Gompertz law, in line with empirical observations. Finally, we propose a generic allometric scaling for the origin of soft bounds. These findings shed light on the impact on a system of such "scaling" constraint and on its possible generating mechanisms.

  18. Soft bounds on diffusion produce skewed distributions and Gompertz growth

    NASA Astrophysics Data System (ADS)

    Mandrà, Salvatore; Lagomarsino, Marco Cosentino; Gherardi, Marco

    2014-09-01

    Constraints can affect dramatically the behavior of diffusion processes. Recently, we analyzed a natural and a technological system and reported that they perform diffusion-like discrete steps displaying a peculiar constraint, whereby the increments of the diffusing variable are subject to configuration-dependent bounds. This work explores theoretically some of the revealing landmarks of such phenomenology, termed "soft bound." At long times, the system reaches a steady state irreversibly (i.e., violating detailed balance), characterized by a skewed "shoulder" in the density distribution, and by a net local probability flux, which has entropic origin. The largest point in the support of the distribution follows a saturating dynamics, expressed by the Gompertz law, in line with empirical observations. Finally, we propose a generic allometric scaling for the origin of soft bounds. These findings shed light on the impact on a system of such "scaling" constraint and on its possible generating mechanisms.

  19. Restoring the skew quadrupole moment in the Tevatron dipoles

    SciTech Connect

    Harding, D.J.; Bauer, P.C.; Blowers, J.N.; DiMarco, J.; Glass, H.D.; Hanft, R.W.; Carson, J.A.; Robotham, W.F.; Tartaglia, M.A.; Tompkins, J.C.; Velev, G.; /Fermilab

    2005-05-01

    In early 2003 it was realized that mechanical changes in the Tevatron dipoles had led to a deterioration of the magnetic field quality that was hindering operation of the accelerator. After extensive study, a remediation program was started in late 2003 that will continue through 2005. The mechanical and magnetic effects are discussed. The readjustment process and experience are reported, along with other observations on aging magnets. In January 2003 two lines of inquiry converged, leading to the recognition that the severe betatron coupling that was hindering operation of the Tevatron could be explained by a systematic shift on the skew quadrupole field in the dipole magnets of the same size expected from observed mechanical movement of the coils inside the magnet yokes [1]. This paper reports on subsequent magnet studies that were conducted in parallel with additional beam studies and accelerator modeling [2] exploring the feasibility of the eventual remediation effort [3].

  20. GC skew is a conserved property of unmethylated CpG island promoters across vertebrates

    PubMed Central

    Hartono, Stella R.; Korf, Ian F.; Chédin, Frédéric

    2015-01-01

    GC skew is a measure of the strand asymmetry in the distribution of guanines and cytosines. GC skew favors R-loops, a type of three stranded nucleic acid structures that form upon annealing of an RNA strand to one strand of DNA, creating a persistent RNA:DNA hybrid. Previous studies show that GC skew is prevalent at thousands of human CpG island (CGI) promoters and transcription termination regions, which correspond to hotspots of R-loop formation. Here, we investigated the conservation of GC skew patterns in 60 sequenced chordates genomes. We report that GC skew is a conserved sequence characteristic of the CGI promoter class in vertebrates. Furthermore, we reveal that promoter GC skew peaks at the exon 1/ intron1 junction and that it is highly correlated with gene age and CGI promoter strength. Our data also show that GC skew is predictive of unmethylated CGI promoters in a range of vertebrate species and that it imparts significant DNA hypomethylation for promoters with intermediate CpG densities. Finally, we observed that terminal GC skew is conserved for a subset of vertebrate genes that tend to be located significantly closer to their downstream neighbors, consistent with a role for R-loop formation in transcription termination. PMID:26253743

  1. Assessment of seismic performance of skew reinforced concrete box girder bridges

    NASA Astrophysics Data System (ADS)

    Abdel-Mohti, Ahmed; Pekcan, Gokhan

    2013-12-01

    The seismic vulnerability of highway bridges remains an important problem and has received increased attention as a consequence of unprecedented damage observed during several major earthquakes. A significant number of research studies have examined the performance of skew bridges under service and seismic loads. The results of these studies are particularly sensitive to modeling assumptions in view of the interacting parameters. In the present study, three-dimensional improved beam-stick models of two-span highway bridges with skew angles varying from 0° to 60° are developed to investigate the seismic response characteristics of skew box girder bridges. The relative accuracy of beam-stick models is verified against counterpart finite element models. The effect of various parameters and conditions on the overall seismic response was examined such as skew angle, ground motion intensity, soil condition, abutment support conditions, bridge aspect ratio, and foundation-base conditions. The study shows that the improved beam-stick models can be used to conduct accurate nonlinear time history analysis of skew bridges. Skew angle and interacting parameters were found to have significant effect on the behavior of skewed highway bridges. Furthermore, the performance of shear keys may have a predominant effect on the overall seismic response of the skew bridges.

  2. A proof for Rhiel's range estimator of the coefficient of variation for skewed distributions.

    PubMed

    Rhiel, G Steven

    2007-02-01

    In this research study is proof that the coefficient of variation (CV(high-low)) calculated from the highest and lowest values in a set of data is applicable to specific skewed distributions with varying means and standard deviations. Earlier Rhiel provided values for d(n), the standardized mean range, and a(n), an adjustment for bias in the range estimator of micro. These values are used in estimating the coefficient of variation from the range for skewed distributions. The d(n) and an values were specified for specific skewed distributions with a fixed mean and standard deviation. In this proof it is shown that the d(n) and an values are applicable for the specific skewed distributions when the mean and standard deviation can take on differing values. This will give the researcher confidence in using this statistic for skewed distributions regardless of the mean and standard deviation.

  3. Flexural Vibration Of Skew Mindlin Plates With Oblique Internal Line Supports

    NASA Astrophysics Data System (ADS)

    Xiang, Y.; Kitipornchai, S.; Liew, K. M.; Wang, C. M.

    1994-12-01

    A free vibration analysis of moderately thick skew plates with oblique internal line supports is presented. Mindlin's plate theory is employed and the pb -2 Rayleigh-Ritz method is applied to obtain the governing eigenvalue equation for internally supported skew plates. A set of natural frequencies for skew Mindlin plates with oblique internal line supports having different combinations of boundary conditions has been determined for various aspect ratios a/b, relative thickness ratios t/b and skew angles α. The validity of the approach is illustrated by comparing the results with other established values. From literature searches, it appears that no work has previously been done on the free vibration of moderately thick skew plates with oblique internal line supports. Thus this paper may provide some important information to designers and engineers for use in practical applications.

  4. Skewness of cloud droplet spectrum and an improved estimation for its relative dispersion

    NASA Astrophysics Data System (ADS)

    Liu, Yu; Lu, Chunsong; Li, Weiliang

    2016-05-01

    The relative dispersion of the cloud droplet spectrum is a very important parameter in describing and modeling cloud microphysical processes. Based on the definition of skewness as well as theoretical and data analyses, a linear fitting relationship (α = 2.91ɛ-0.59) between skewness (α) and relative dispersion (ɛ) is established and a new method is developed to estimate the relative dispersion of the cloud droplet spectrum. The new method does not depend on any assumption of a particular distribution for the cloud droplet spectrum and has broader applicability than the previous methods. Comparisons of the three methods for the relative dispersion with the observed data supported the following conclusions. (1) The skewness of the cloud droplet spectrum is asymmetrically distributed. An assumption of zero skewness in quantifying the relative dispersion inevitably results in relatively large deviations from the observations. Errors of the estimated relative dispersion due to the omission of the skewness term are not solely related to the skewness, but rather to the product of the skewness and relative dispersion. (2) The use of the assumption that the cloud droplet spectrum takes a gamma distribution is similar to the assumption that the skewness is twice the relative dispersion. This leads to a better accuracy in estimating the relative dispersion than that with zero skewness assumption. (3) Comparisons with observations show that the new method is more accurate than the one under gamma distribution assumption and is the best among all the three methods. (4) It is believed that finding a better correlation between the skewness and the relative dispersion would further reduce the deviations for the estimated relative dispersion.

  5. Skew redundant MEMS IMU calibration using a Kalman filter

    NASA Astrophysics Data System (ADS)

    Jafari, M.; Sahebjameyan, M.; Moshiri, B.; Najafabadi, T. A.

    2015-10-01

    In this paper, a novel calibration procedure for skew redundant inertial measurement units (SRIMUs) based on micro-electro mechanical systems (MEMS) is proposed. A general model of the SRIMU measurements is derived which contains the effects of bias, scale factor error and misalignments. For more accuracy, the effect of lever arms of the accelerometers to the center of the table are modeled and compensated in the calibration procedure. Two separate Kalman filters (KFs) are proposed to perform the estimation of error parameters for gyroscopes and accelerometers. The predictive error minimization (PEM) stochastic modeling method is used to simultaneously model the effect of bias instability and random walk noise on the calibration Kalman filters to diminish the biased estimations. The proposed procedure is simulated numerically and has expected experimental results. The calibration maneuvers are applied using a two-axis angle turntable in a way that the persistency of excitation (PE) condition for parameter estimation is met. For this purpose, a trapezoidal calibration profile is utilized to excite different deterministic error parameters of the accelerometers and a pulse profile is used for the gyroscopes. Furthermore, to evaluate the performance of the proposed KF calibration method, a conventional least squares (LS) calibration procedure is derived for the SRIMUs and the simulation and experimental results compare the functionality of the two proposed methods with each other.

  6. Time Variations of Scour Below Submerged Skewed Pipelines

    NASA Astrophysics Data System (ADS)

    Yusoff, M. A. M.; Azamathulla, H. M.; Ghani, A. A.

    2016-07-01

    The presence of pipe across river initiates the piping effect combined with the stagnation eddy and vortex system in the vicinity of the pipeline. The main objective of the research is to investigate the physics of scour below skewed pipeline in river crossing as well as the time variations of the scour development. In this study, the experiments were conducted for four different angles of pipe (30°, 45°, 60° and 90°) across a channel and placed on the sediment bed with e/D = 0. The scour development for flow shallowness y/D = 3 and y/D = 4, initiated at downstream side of the pipe, where the bed sediment appeared to be ejected from the bed due to the piping effect process. At the initial stage, the scour process for 150mm flow depth enlarged rapidly. Whilst, the scour process for 200 mm flow depth slowly developed and after certain time, the sediment bed scoured rapidly. The scour depth increased considerably at development stage and the suspended load near the bed especially below the pipe decreased significantly compared to the initial stage. The rate of sediment eroded from the sediment bed decreased at the stabilization phase. The equilibrium phase of the scour depth considered achieved as the dimensions of the scour hole do not change significantly.

  7. Abundant rich phase transitions in step-skew products

    NASA Astrophysics Data System (ADS)

    Díaz, L. J.; Gelfert, K.; Rams, M.

    2014-09-01

    We study phase transitions for the topological pressure of geometric potentials of transitive sets. The sets considered are partially hyperbolic having a step-skew product dynamics over a horseshoe with one-dimensional fibres corresponding to the central direction. The sets are genuinely non-hyperbolic, containing intermingled horseshoes of different hyperbolic, behaviour (contracting and expanding centre). We construct for every k ⩾ 1 a diffeomorphism F with a transitive set Λ as above such that the pressure map P(t) = P(t φ) of the potential \\varphi= -log \\,\\Vert \\rmd F|_{E^c}\\Vert (Ec the central direction) defined on Λ has k rich phase transitions. This means that there are parameters tℓ, ℓ = 0, …, k - 1, where P(t) is not differentiable and this lack of differentiability is due to the coexistence of two equilibrium states of tℓ φ with positive entropy and different Birkhoff averages. Each phase transition is associated with a gap in the central Lyapunov spectrum of F on Λ.

  8. Regression for skewed biomarker outcomes subject to pooling.

    PubMed

    Mitchell, Emily M; Lyles, Robert H; Manatunga, Amita K; Danaher, Michelle; Perkins, Neil J; Schisterman, Enrique F

    2014-03-01

    Epidemiological studies involving biomarkers are often hindered by prohibitively expensive laboratory tests. Strategically pooling specimens prior to performing these lab assays has been shown to effectively reduce cost with minimal information loss in a logistic regression setting. When the goal is to perform regression with a continuous biomarker as the outcome, regression analysis of pooled specimens may not be straightforward, particularly if the outcome is right-skewed. In such cases, we demonstrate that a slight modification of a standard multiple linear regression model for poolwise data can provide valid and precise coefficient estimates when pools are formed by combining biospecimens from subjects with identical covariate values. When these x-homogeneous pools cannot be formed, we propose a Monte Carlo expectation maximization (MCEM) algorithm to compute maximum likelihood estimates (MLEs). Simulation studies demonstrate that these analytical methods provide essentially unbiased estimates of coefficient parameters as well as their standard errors when appropriate assumptions are met. Furthermore, we show how one can utilize the fully observed covariate data to inform the pooling strategy, yielding a high level of statistical efficiency at a fraction of the total lab cost. PMID:24521420

  9. Statistics on Cannabis Users Skew Perceptions of Cannabis Use

    PubMed Central

    Burns, Rachel M.; Caulkins, Jonathan P.; Everingham, Susan S.; Kilmer, Beau

    2013-01-01

    Collecting information about the prevalence of cannabis use is necessary but not sufficient for understanding the size, dynamics, and outcomes associated with cannabis markets. This paper uses two data sets describing cannabis consumption in the United States and Europe to highlight (1) differences in inferences about sub-populations based on the measure used to quantify cannabis-related activity; (2) how different measures of cannabis-related activity can be used to more accurately describe trends in cannabis usage over time; and (3) the correlation between frequency of use in the past-month and average grams consumed per use-day. Key findings: focusing on days of use instead of prevalence shows substantially greater increases in U.S. cannabis use in recent years; however, the recent increase is mostly among adults, not youth. Relatively more rapid growth in use days also occurred among the college-educated and Hispanics. Further, data from a survey conducted in seven European countries show a strong positive correlation between frequency of use and quantity consumed per day of use, suggesting consumption is even more skewed toward the minority of heavy users than is suggested by days-of-use calculations. PMID:24223560

  10. Social and genetic structure of paper wasp cofoundress associations: tests of reproductive skew models.

    PubMed

    Field, J; Solís, C R; Queller, D C; Strassmann, J E

    1998-06-01

    Recent models postulate that the members of a social group assess their ecological and social environments and agree a "social contract" of reproductive partitioning (skew). We tested social contracts theory by using DNA microsatellites to measure skew in 24 cofoundress associations of paper wasps, Polistes bellicosus. In contrast to theoretical predictions, there was little variation in cofoundress relatedness, and relatedness either did not predict skew or was negatively correlated with it; the dominant/subordinate size ratio, assumed to reflect relative fighting ability, did not predict skew; and high skew was associated with decreased aggression by the rank 2 subordinate toward the dominant. High skew was associated with increased group size. A difficulty with measuring skew in real systems is the frequent changes in group composition that commonly occur in social animals. In P. bellicosus, 61% of egg layers and an unknown number of non-egg layers were absent by the time nests were collected. The social contracts models provide an attractive general framework linking genetics, ecology, and behavior, but there have been few direct tests of their predictions. We question assumptions underlying the models and suggest directions for future research.

  11. Modulation of Root Skewing in Arabidopsis by Apyrases and Extracellular ATP.

    PubMed

    Yang, Xingyan; Wang, Bochu; Farris, Ben; Clark, Greg; Roux, Stanley J

    2015-11-01

    When plant primary roots grow along a tilted surface that is impenetrable, they can undergo a slanted deviation from the direction of gravity called skewing. Skewing is induced by touch stimuli which the roots experience as they grow along the surface. Touch stimuli also induce the release of extracellular ATP (eATP) into the plant's extracellular matrix, and two apyrases (NTPDases) in Arabidopsis, APY1 and APY2, can help regulate the concentration of eATP. The primary roots of seedlings overexpressing APY1 show less skewing than wild-type plants. Plants suppressed in their expression of APY1 show more skewing than wild-type plants. Correspondingly, chemical inhibition of apyrase activity increased skewing in mutants and wild-type roots. Exogenous application of ATP or ATPγS also increased skewing in wild-type roots, which could be blocked by co-incubation with a purinergic receptor antagonist. These results suggest a model in which gradients of eATP set up by differential touch stimuli along roots help direct skewing in roots growing along an impenetrable surface.

  12. Log Pearson type 3 quantile estimators with regional skew information and low outlier adjustments

    USGS Publications Warehouse

    Griffis, V.W.; Stedinger, J.R.; Cohn, T.A.

    2004-01-01

    [1] The recently developed expected moments algorithm (EMA) [Cohn et al., 1997] does as well as maximum likelihood estimations at estimating log-Pearson type 3 (LP3) flood quantiles using systematic and historical flood information. Needed extensions include use of a regional skewness estimator and its precision to be consistent with Bulletin 17B. Another issue addressed by Bulletin 17B is the treatment of low outliers. A Monte Carlo study compares the performance of Bulletin 17B using the entire sample with and without regional skew with estimators that use regional skew and censor low outliers, including an extended EMA estimator, the conditional probability adjustment (CPA) from Bulletin 17B, and an estimator that uses probability plot regression (PPR) to compute substitute values for low outliers. Estimators that neglect regional skew information do much worse than estimators that use an informative regional skewness estimator. For LP3 data the low outlier rejection procedure generally results in no loss of overall accuracy, and the differences between the MSEs of the estimators that used an informative regional skew are generally modest in the skewness range of real interest. Samples contaminated to model actual flood data demonstrate that estimators which give special treatment to low outliers significantly outperform estimators that make no such adjustment.

  13. Identification of Intellectual Disability Genes in Female Patients with a Skewed X-Inactivation Pattern.

    PubMed

    Fieremans, Nathalie; Van Esch, Hilde; Holvoet, Maureen; Van Goethem, Gert; Devriendt, Koenraad; Rosello, Monica; Mayo, Sonia; Martinez, Francisco; Jhangiani, Shalini; Muzny, Donna M; Gibbs, Richard A; Lupski, James R; Vermeesch, Joris R; Marynen, Peter; Froyen, Guy

    2016-08-01

    Intellectual disability (ID) is a heterogeneous disorder with an unknown molecular etiology in many cases. Previously, X-linked ID (XLID) studies focused on males because of the hemizygous state of their X chromosome. Carrier females are generally unaffected because of the presence of a second normal allele, or inactivation of the mutant X chromosome in most of their cells (skewing). However, in female ID patients, we hypothesized that the presence of skewing of X-inactivation would be an indicator for an X chromosomal ID cause. We analyzed the X-inactivation patterns of 288 females with ID, and found that 22 (7.6%) had extreme skewing (>90%), which is significantly higher than observed in the general population (3.6%; P = 0.029). Whole-exome sequencing of 19 females with extreme skewing revealed causal variants in six females in the XLID genes DDX3X, NHS, WDR45, MECP2, and SMC1A. Interestingly, variants in genes escaping X-inactivation presumably cause both XLID and skewing of X-inactivation in three of these patients. Moreover, variants likely accounting for skewing only were detected in MED12, HDAC8, and TAF9B. All tested candidate causative variants were de novo events. Hence, extreme skewing is a good indicator for the presence of X-linked variants in female patients.

  14. Bordered tug-of-war models are neither general nor predictive of reproductive skew.

    PubMed

    Nonacs, Peter

    2010-10-21

    Models of reproductive skew assume reproductive shares are either conceded, competed over, or both. Previous mathematical evaluations found that simultaneous concessions and contests are evolutionarily unstable. Recently, Shen and Reeve (2010) challenged these conclusions and developed a series of sub-models they argued to be a unified approach to reproductive skew: the general bordered tug-of-war (BTOW). However, BTOW fails as a general model for two reasons: (1) the BTOW strategy cannot invade populations where individuals either only compete for or only concede reproductive shares and (2) contrary to Shen and Reeve's assertion, BTOW populations are easily invaded by strategies with fewer or no concessions, but competing at lower levels. The failure of BTOW as a general model has major implications for interpreting experiments on reproductive skew. A large number of studies have measured the effects of genetic relatedness and competitive ability on reproductive skew, with a great majority finding no significant correlation between variation in within-group relatedness or competitive ability and across-group differences in skew. No model of reproductive skew except one variant of the BTOW predicts such results. With the rejection of BTOW as a valid general model, it is clear that these results are contradictory to reproductive skew theory rather than supportive of it.

  15. Spreading-rate-dependent anomalous skewness and the estimate of the chron 32 palaeomagnetic pole for the Pacific plate

    NASA Astrophysics Data System (ADS)

    Koivisto, E.; Gordon, R.; Dyment, J.; Arkani-Hamed, J.

    2006-12-01

    Palaeomagnetic poles can be determined from asymmetry (skewness) of marine magnetic anomalies. Early works applying the skewness method were limited by the discovery of an apparently systematic error known as anomalous skewness (Cande 1976). Anomalous skewness can be thought of as the systematic difference between the observed skewness and the skewness predicted by a simple magnetization model with rectangular 2-D layer 2A prisms of alternating polarity separated by vertical boundaries. In the early works, anomalous skewness could be isolated for anomalies with counterparts across a mid-ocean ridge, but was much harder to estimate for anomalies with subducted counterparts, as is mostly the case in the Pacific plate. Petronotis et al. (1992) presented a solution to this problem by simultaneously estimating anomalous skewness and a best-fitting palaeomagnetic pole from skewness data from a single plate. In their approach, anomalous skewness is assumed to be identical for different crossings of the same plate and any spreading-rate dependence of anomalous skewness is neglected. Nonetheless, anomalous skewness of marine magnetic anomalies is observed to decrease with increasing spreading rate and become negligible above spreading rates of about 50 mm yr-1 (e.g. Roest et al. 1992; Dyment et al. 1994). Dyment &Arkani-Hamed (1995) proposed a model in which the magnetic structure of the oceanic lithosphere is dependent on spreading rate with parameters adjusted to fit the observed spreading- rate dependence of anomalous skewness for some key anomalies. Here we apply their model to determine a new Maastrichtian palaeomagnetic pole for the Pacific plate from skewness estimates of magnetic anomaly 32. Previously Petronotis &Gordon (1999) obtained a palaeopole assuming spreading-rate independent anomalous skewness for the same data used here. They also investigated the possible dependence of anomalous skewness on spreading rate and found it to have negligible effect on their

  16. Skewness in large-scale structure and non-Gaussian initial conditions

    NASA Technical Reports Server (NTRS)

    Fry, J. N.; Scherrer, Robert J.

    1994-01-01

    We compute the skewness of the galaxy distribution arising from the nonlinear evolution of arbitrary non-Gaussian intial conditions to second order in perturbation theory including the effects of nonlinear biasing. The result contains a term identical to that for a Gaussian initial distribution plus terms which depend on the skewness and kurtosis of the initial conditions. The results are model dependent; we present calculations for several toy models. At late times, the leading contribution from the initial skewness decays away relative to the other terms and becomes increasingly unimportant, but the contribution from initial kurtosis, previously overlooked, has the same time dependence as the Gaussian terms. Observations of a linear dependence of the normalized skewness on the rms density fluctuation therefore do not necessarily rule out initially non-Gaussian models. We also show that with non-Gaussian initial conditions the first correction to linear theory for the mean square density fluctuation is larger than for Gaussian models.

  17. On some properties of reflected skew Brownian motions and applications to dispersion in heterogeneous media

    NASA Astrophysics Data System (ADS)

    Song, Shiyu; Wang, Suxin; Wang, Yongjin

    2016-08-01

    Motivated by the close connection between the skew Brownian motion and the random particle motion in heterogeneous media, we investigate the reflected skew Brownian motion and try to find out its relationship with the corresponding dispersion problem when there exists a reflecting boundary. Through the use of the knowledge of stochastic analysis, we provide some basic properties of reflected skew Brownian motions, including the transition density, the Laplace transform of the first passage time, and some related results. A simple method to generate the sample path is also proposed. At the end of this paper, we reveal the strong relationship between the reflected skew Brownian motion and the solute dispersion in the presence of a sharp interface and a reflecting boundary.

  18. Fast frequency domain method to detect skew in a document image

    NASA Astrophysics Data System (ADS)

    Mehta, Sunita; Walia, Ekta; Dutta, Maitreyee

    2015-12-01

    In this paper, a new fast frequency domain method based on Discrete Wavelet Transform and Fast Fourier Transform has been implemented for the determination of the skew angle in a document image. Firstly, image size reduction is done by using two-dimensional Discrete Wavelet Transform and then skew angle is computed using Fast Fourier Transform. Skew angle error is almost negligible. The proposed method is experimented using a large number of documents having skew between -90° and +90° and results are compared with Moments with Discrete Wavelet Transform method and other commonly used existing methods. It has been determined that this method works more efficiently than the existing methods. Also, it works with typed, picture documents having different fonts and resolutions. It overcomes the drawback of the recently proposed method of Moments with Discrete Wavelet Transform that does not work with picture documents.

  19. Asymptotic performance of the quadratic discriminant function to skewed training samples.

    PubMed

    Adebanji, Atinuke; Asamoah-Boaheng, Michael; Osei-Tutu, Olivia

    2016-01-01

    This study investigates the asymptotic performance of the quadratic discriminant function (QDF) under skewed training samples. The main objective of this study is to evaluate the performance of the QDF under skewed distribution considering different sample size ratios, varying the group centroid separators and the number of variables. Three populations [Formula: see text] with increasing group centroid separator function were considered. A multivariate normal distributed data was simulated with MatLab R2009a. There was an increase in the average error rates of the sample size ratios 1:2:2 and 1:2:3 as the total sample size increased asymptotically in the skewed distribution when the centroid separator increased from 1 to 3. The QDF under the skewed distribution performed better for the sample size ratio 1:1:1 as compared to the other sampling ratios and under centroid separator [Formula: see text]. PMID:27652103

  20. 12. Underside of Skew SpanHot Metal system on right, toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Underside of Skew Span-Hot Metal system on right, toward Rocker Bent. - Monongahela Connecting Railroad Company, Hot Metal Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  1. An Adaptive Method for Reducing Clock Skew in an Accumulative Z-Axis Interconnect System

    NASA Technical Reports Server (NTRS)

    Bolotin, Gary; Boyce, Lee

    1997-01-01

    This paper will present several methods for adjusting clock skew variations that occur in a n accumulative z-axis interconnect system. In such a system, delay between modules in a function of their distance from one another. Clock distribution in a high-speed system, where clock skew must be kept to a minimum, becomes more challenging when module order is variable before design.

  2. A study on the effects of a skewed distribution on the EWMA and MA charts

    NASA Astrophysics Data System (ADS)

    Liew, Jeng Young; Khoo, Michael Boon Chong; Neoh, Siang Gee

    2014-07-01

    The control chart is the most powerful tool in statistical process control. A control chart is a graphical display used to determine the presence of assignable causes so that prompt corrective actions can be taken to remove such causes before many nonconforming products are produced. The exponentially weighted moving average (EWMA) and moving average (MA) charts are very effective in detecting small and moderate shifts in the process mean. These two charts are constructed based on the properties of the normal distribution. In many practical applications, the validity of the normality assumption is always doubted as the process distribution could be skewed. A skewed distribution can result in a higher incidence of false alarms. This is due to the inconsistencies between the spread of a skewed distribution and the normality assumption employed in setting up a control chart. This paper studies the effects of a skewed distribution on the performances of the EWMA and MA charts, in terms of the charts' false alarm rates. We compare the in-control average run length (ARL0) performance of these two charts when the underlying distributions are normal and skewed. The gamma distribution is selected to represent the skewed distribution. A Monte Carlo simulation using the Statistical Analysis System (SAS) software is carried out to compute the necessary ARL0s. The findings of this study show that the ARL0 performance of the EWMA and MA charts is substantially affected by the skewed distribution. However, the MA chart is not as robust as the EWMA chart, in terms of the ARL0, when the distribution is skewed.

  3. Normalization of high dimensional genomics data where the distribution of the altered variables is skewed.

    PubMed

    Landfors, Mattias; Philip, Philge; Rydén, Patrik; Stenberg, Per

    2011-01-01

    Genome-wide analysis of gene expression or protein binding patterns using different array or sequencing based technologies is now routinely performed to compare different populations, such as treatment and reference groups. It is often necessary to normalize the data obtained to remove technical variation introduced in the course of conducting experimental work, but standard normalization techniques are not capable of eliminating technical bias in cases where the distribution of the truly altered variables is skewed, i.e. when a large fraction of the variables are either positively or negatively affected by the treatment. However, several experiments are likely to generate such skewed distributions, including ChIP-chip experiments for the study of chromatin, gene expression experiments for the study of apoptosis, and SNP-studies of copy number variation in normal and tumour tissues. A preliminary study using spike-in array data established that the capacity of an experiment to identify altered variables and generate unbiased estimates of the fold change decreases as the fraction of altered variables and the skewness increases. We propose the following work-flow for analyzing high-dimensional experiments with regions of altered variables: (1) Pre-process raw data using one of the standard normalization techniques. (2) Investigate if the distribution of the altered variables is skewed. (3) If the distribution is not believed to be skewed, no additional normalization is needed. Otherwise, re-normalize the data using a novel HMM-assisted normalization procedure. (4) Perform downstream analysis. Here, ChIP-chip data and simulated data were used to evaluate the performance of the work-flow. It was found that skewed distributions can be detected by using the novel DSE-test (Detection of Skewed Experiments). Furthermore, applying the HMM-assisted normalization to experiments where the distribution of the truly altered variables is skewed results in considerably higher

  4. Higher-order skewness and excess coefficients of some probability distributions applicable to optical propagation phenomena

    NASA Technical Reports Server (NTRS)

    Majumdar, A. K.

    1979-01-01

    Expressions are derived for higher-order skewness and excess coefficients using central moments and cumulants up to 8th order. These coefficients are then calculated for three probability distributions: (1) Log-normal, (2) Rice-Nakagami, and (3) Gamma distributions. Curves are given to shown the variation of skewness with excess coefficients for these distributions. These curves are independent of the particular distribution parameters. This method is useful for studying fluctuating phenomena, which obey non-Gaussian statistics.

  5. Intracolonial genetic variation affects reproductive skew and colony productivity during colony foundation in a parthenogenetic termite

    PubMed Central

    2014-01-01

    Background In insect societies, intracolonial genetic variation is predicted to affect both colony efficiency and reproductive skew. However, because the effects of genetic variation on these two colony characteristics have been tested independently, it remains unclear whether they are affected by genetic variation independently or in a related manner. Here we test the effect of genetic variation on colony efficiency and reproductive skew in a rhinotermitid termite, Reticulitermes speratus, a species in which female-female pairs can facultatively found colonies. We established colonies using two types of female-female pairs: colonies founded by sisters (i.e., sister-pair colonies) and those founded by females from different colonies (i.e., unrelated-pair colonies). Colony growth and reproductive skew were then compared between the two types of incipient colonies. Results At 15 months after colony foundation, unrelated-pair colonies were larger than sister-pair colonies, although the caste ratio between workers and nymphs, which were alternatively differentiated from young larvae, did not differ significantly. Microsatellite DNA analyses of both founders and their parthenogenetically produced offspring indicated that, in both sister-pair and unrelated-pair colonies, there was no significant skew in the production of eggs, larvae, workers and soldiers. Nymph production, however, was significantly more skewed in the sister-pair colonies than in unrelated-pair colonies. Because nymphs can develop into winged adults (alates) or nymphoid reproductives, they have a higher chance of direct reproduction than workers in this species. Conclusions Our results support the idea that higher genetic variation among colony members could provide an increase in colony productivity, as shown in hymenopteran social insects. Moreover, this study suggests that low genetic variation (high relatedness) between founding females increases reproductive skew via one female preferentially

  6. Static performance investigation of a skewed-throat multiaxis thrust-vectoring nozzle concept

    NASA Technical Reports Server (NTRS)

    Wing, David J.

    1994-01-01

    The static performance of a jet exhaust nozzle which achieves multiaxis thrust vectoring by physically skewing the geometric throat has been characterized in the static test facility of the 16-Foot Transonic Tunnel at NASA Langley Research Center. The nozzle has an asymmetric internal geometry defined by four surfaces: a convergent-divergent upper surface with its ridge perpendicular to the nozzle centerline, a convergent-divergent lower surface with its ridge skewed relative to the nozzle centerline, an outwardly deflected sidewall, and a straight sidewall. The primary goal of the concept is to provide efficient yaw thrust vectoring by forcing the sonic plane (nozzle throat) to form at a yaw angle defined by the skewed ridge of the lower surface contour. A secondary goal is to provide multiaxis thrust vectoring by combining the skewed-throat yaw-vectoring concept with upper and lower pitch flap deflections. The geometric parameters varied in this investigation included lower surface ridge skew angle, nozzle expansion ratio (divergence angle), aspect ratio, pitch flap deflection angle, and sidewall deflection angle. Nozzle pressure ratio was varied from 2 to a high of 11.5 for some configurations. The results of the investigation indicate that efficient, substantial multiaxis thrust vectoring was achieved by the skewed-throat nozzle concept. However, certain control surface deflections destabilized the internal flow field, which resulted in substantial shifts in the position and orientation of the sonic plane and had an adverse effect on thrust-vectoring and weight flow characteristics. By increasing the expansion ratio, the location of the sonic plane was stabilized. The asymmetric design resulted in interdependent pitch and yaw thrust vectoring as well as nonzero thrust-vector angles with undeflected control surfaces. By skewing the ridges of both the upper and lower surface contours, the interdependency between pitch and yaw thrust vectoring may be eliminated

  7. Modeling absolute differences in life expectancy with a censored skew-normal regression approach

    PubMed Central

    Clough-Gorr, Kerri; Zwahlen, Marcel

    2015-01-01

    Parameter estimates from commonly used multivariable parametric survival regression models do not directly quantify differences in years of life expectancy. Gaussian linear regression models give results in terms of absolute mean differences, but are not appropriate in modeling life expectancy, because in many situations time to death has a negative skewed distribution. A regression approach using a skew-normal distribution would be an alternative to parametric survival models in the modeling of life expectancy, because parameter estimates can be interpreted in terms of survival time differences while allowing for skewness of the distribution. In this paper we show how to use the skew-normal regression so that censored and left-truncated observations are accounted for. With this we model differences in life expectancy using data from the Swiss National Cohort Study and from official life expectancy estimates and compare the results with those derived from commonly used survival regression models. We conclude that a censored skew-normal survival regression approach for left-truncated observations can be used to model differences in life expectancy across covariates of interest. PMID:26339544

  8. Starving the competition: a proximate cause of reproductive skew in burying beetles (Nicrophorus vespilloides)

    PubMed Central

    Eggert, Anne-Katrin; Otte, Tobias; Müller, Josef K

    2008-01-01

    Proximate mechanisms underlying reproductive skew are obscure in many animals that breed communally. Here, we address causes of reproductive skew in brood-parasitic associations of burying beetles (Nicrophorus vespilloides). Male and female burying beetles feed and defend their larvae on buried carcasses. When several females locate the same small carcass, they engage in violent physical altercations. The subordinate then acts as an intraspecific brood parasite, laying eggs, but not providing care. The dominant female largely monopolizes access to the carcass; she alone provides parental care and her share of the brood is much larger than the subordinate's. On larger carcasses, subordinates have greater access to the carcass than on small ones, and reproductive skew is reduced. Differential fecundity, ovicide and larvicide have been suggested as causes of skew on small carcasses. Here, we report the results of the experiments pertaining to the first two of these potential mechanisms. Ovicide did not significantly contribute to reproductive skew on small carcasses, but differential fecundity did. Fecundity differences were due to dominance status, not body size per se. Fecundity differences disappeared when supplemental food was available, suggesting that reduced access to the carcass limits fecundity by causing nutritional deficiencies. Supplemental food prevented such nutritional deficiencies and allowed subordinates to produce as many eggs as dominants. Apparently, aggressive behaviour by dominants functions in the context of reproductive competition, limiting subordinate reproduction by preventing food intake on the carcass. PMID:18647719

  9. Skew-laplace and cell-size distribution in microbial axenic cultures: statistical assessment and biological interpretation.

    PubMed

    Julià, Olga; Vidal-Mas, Jaume; Panikov, Nicolai S; Vives-Rego, Josep

    2010-01-01

    We report a skew-Laplace statistical analysis of both flow cytometry scatters and cell size from microbial strains primarily grown in batch cultures, others in chemostat cultures and bacterial aquatic populations. Cytometry scatters best fit the skew-Laplace distribution while cell size as assessed by an electronic particle analyzer exhibited a moderate fitting. Unlike the cultures, the aquatic bacterial communities clearly do not fit to a skew-Laplace distribution. Due to its versatile nature, the skew-Laplace distribution approach offers an easy, efficient, and powerful tool for distribution of frequency analysis in tandem with the flow cytometric cell sorting.

  10. Skew-Laplace and Cell-Size Distribution in Microbial Axenic Cultures: Statistical Assessment and Biological Interpretation

    PubMed Central

    Julià, Olga; Vidal-Mas, Jaume; Panikov, Nicolai S.; Vives-Rego, Josep

    2010-01-01

    We report a skew-Laplace statistical analysis of both flow cytometry scatters and cell size from microbial strains primarily grown in batch cultures, others in chemostat cultures and bacterial aquatic populations. Cytometry scatters best fit the skew-Laplace distribution while cell size as assessed by an electronic particle analyzer exhibited a moderate fitting. Unlike the cultures, the aquatic bacterial communities clearly do not fit to a skew-Laplace distribution. Due to its versatile nature, the skew-Laplace distribution approach offers an easy, efficient, and powerful tool for distribution of frequency analysis in tandem with the flow cytometric cell sorting. PMID:20592754

  11. Effective step-skew method for cogging torque reduction in surface-mounted permanent magnet synchronous motor

    NASA Astrophysics Data System (ADS)

    Kim, Tae-Woo; Chang, Jung-Hwan

    2013-08-01

    This paper suggests an effective step-skew method to reduce the cogging torque of a surface-mounted permanent magnet synchronous motor (SPMSM). The main concept of the proposed method is to adjust each step length by considering the non-uniform air gap flux density distribution in the axial direction. The results show that the proposed step-skew method reduces the net cogging torque compared with the conventional step-skew method and is more effective for smaller stacking lengths and larger skew steps.

  12. Distribution of mean Doppler shift, spectral width, and skewness of coherent 50-MHz auroral radar backscatter

    SciTech Connect

    Watermann, J.; McNamara, A.G. ); Sofko, G.J.; Koehler, J.A. )

    1989-06-01

    Some 7,700 radio aurora spectra obtained from a six link 50-MHz CW radar network set up on the Canadian prairies were analyzed with respect to the distributions of mean Doppler shift, spectral width and skewness. A comparison with recently published SABRE results obtained at 153 MHz shows substantial differences in the distributions which are probably due to different experimental and geophysical conditions. The spectra are mostly broad with mean Doppler shifts close to zero (type II spectra). The typical groupings of type I and type III spectra are clearly identified. All types appear to be in general much more symmetric than those recorded with SABRE, and the skewness is only weakly dependent on the sign of the mean Doppler shift. Its distribution peaks near zero and shows a weak positive correlation with the type II Doppler shifts while the mostly positive type I Doppler shifts are slightly negatively correlated with the skewness.

  13. A Berger-type theorem for metric connections with skew-symmetric torsion

    NASA Astrophysics Data System (ADS)

    Reggiani, Silvio

    2013-03-01

    We prove a Berger-type theorem which asserts that if the orthogonal subgroup generated by the torsion tensor (pulled back to a point by parallel transport) of a metric connection with skew-symmetric torsion is not transitive on the sphere, then the space must be locally isometric to a Lie group with a bi-invariant metric or its symmetric dual (we assume the space to be locally irreducible). We also prove that a (simple) Lie group with a bi-invariant metric admits only two flat metric connections with skew-symmetric torsion: the two flat canonical connections. In particular, we get a refinement of a well-known theorem of Cartan and Schouten. Finally, we show that the holonomy group of a metric connection with skew-symmetric torsion on these spaces generically coincides with the Riemannian holonomy.

  14. Modeling the effects of wave skewness and beach cusps on littoral sand transport

    USGS Publications Warehouse

    Haas, K.A.; Check, L.A.; Hanes, D.M.

    2008-01-01

    A process-based numerical modeling system is utilized for predicting littoral sand transport. The intent is to examine conditions slightly more complex than linear waves impinging upon a plane beach. Two factors that we examine are wave skewness and longshore varying bathymetry. An empirical model is used for calculating the skewed bottom wave orbital velocity. The advection of sediment due to the skewed wave velocity is larger and in the direction of the waves, opposite to the results with sinusoidal wave velocities, due to the increase in the bottom shear stress under the wave crests. The model system is also applied to bathymetry containing beach cusps. When the wave field has relatively weak longshore wave power, the currents and the littoral transport exhibit significant longshore variability, thereby altering the overall mean littoral transport.

  15. Perceived quality of wood images influenced by the skewness of image histogram

    NASA Astrophysics Data System (ADS)

    Katsura, Shigehito; Mizokami, Yoko; Yaguchi, Hirohisa

    2015-08-01

    The shape of image luminance histograms is related to material perception. We investigated how the luminance histogram contributed to improvements in the perceived quality of wood images by examining various natural wood and adhesive vinyl sheets with printed wood grain. In the first experiment, we visually evaluated the perceived quality of wood samples. In addition, we measured the colorimetric parameters of the wood samples and calculated statistics of image luminance. The relationship between visual evaluation scores and image statistics suggested that skewness and kurtosis affected the perceived quality of wood. In the second experiment, we evaluated the perceived quality of wood images with altered luminance skewness and kurtosis using a paired comparison method. Our result suggests that wood images are more realistic if the skewness of the luminance histogram is slightly negative.

  16. Gaudin-type models, non-skew-symmetric classical r-matrices and nested Bethe ansatz

    NASA Astrophysics Data System (ADS)

    Skrypnyk, T.

    2015-02-01

    We consider quantum integrable systems associated with the Lie algebra gl (n) and Cartan-invariant non-dynamical non-skew-symmetric classical r-matrices. We describe the sub-class of Cartan-invariant non-skew-symmetric r-matrices for which exists the standard procedure of the nested Bethe ansatz associated with the chain of embeddings gl (n) ⊃ gl (n - 1) ⊃ gl (n - 2) ⊃ ⋯ ⊃ gl (1). We diagonalize the corresponding quantum integrable systems by its means. We illustrate the obtained results by the examples of the generalized Gaudin systems with and without external magnetic field associated with three classes of non-dynamical non-skew-symmetric classical r-matrices.

  17. Skewness in CMB temperature fluctuations from curved cosmic (super-)strings

    SciTech Connect

    Yamauchi, Daisuke; Sendouda, Yuuiti; Yoo, Chul-Moon; Naruko, Atsushi; Sasaki, Misao; Takahashi, Keitaro E-mail: sendouda@yukawa.kyoto-u.ac.jp E-mail: keitaro@a.phys.nagoya-u.ac.jp E-mail: misao@yukawa.kyoto-u.ac.jp

    2010-05-01

    We compute the one-point probability distribution function of small-angle cosmic microwave background temperature fluctuations due to curved cosmic (super-)strings with a simple model of string network by performing Monte Carlo simulations. Taking into account of the correlation between the curvature and the velocity of string segments, there appear non-Gaussian features, specifically non-Gaussian tails and a skewness, in the one-point pdf. The obtained sample skewness for the conventional field-theoretic cosmic strings is g{sub 1} ≈ −0.14, which is consistent with the result reported by Fraisse et al. We also discuss the dependence of the pdf on the intercommuting probability. We find that the standard deviation of the Gaussian part increases and non-Gaussian features are suppressed as the intercommuting probability decreases. For sufficiently small intercommuting probability, the skewness is given by ∼< (a few) × 10{sup −2}.

  18. The log-dynamic brain: how skewed distributions affect network operations

    PubMed Central

    Buzsáki, György; Mizuseki, Kenji

    2014-01-01

    We often assume that the variables of functional and structural brain parameters — such as synaptic weights, the firing rates of individual neurons, the synchronous discharge of neural populations, the number of synaptic contacts between neurons and the size of dendritic boutons — have a bell-shaped distribution. However, at many physiological and anatomical levels in the brain, the distribution of numerous parameters is in fact strongly skewed with a heavy tail, suggesting that skewed (typically lognormal) distributions are fundamental to structural and functional brain organization. This insight not only has implications for how we should collect and analyse data, it may also help us to understand how the different levels of skewed distributions — from synapses to cognition — are related to each other. PMID:24569488

  19. An uncertainty relation in terms of generalized metric adjusted skew information and correlation measure

    NASA Astrophysics Data System (ADS)

    Fan, Ya-Jing; Cao, Huai-Xin; Meng, Hui-Xian; Chen, Liang

    2016-09-01

    The uncertainty principle in quantum mechanics is a fundamental relation with different forms, including Heisenberg's uncertainty relation and Schrödinger's uncertainty relation. In this paper, we prove a Schrödinger-type uncertainty relation in terms of generalized metric adjusted skew information and correlation measure by using operator monotone functions, which reads, U_ρ ^{(g,f)}(A)U_ρ ^{(g,f)}(B)≥ f(0)^2l/k| {Corr}_ρ ^{s(g,f)}(A,B)| ^2 for some operator monotone functions f and g, all n-dimensional observables A, B and a non-singular density matrix ρ . As applications, we derive some new uncertainty relations for Wigner-Yanase skew information and Wigner-Yanase-Dyson skew information.

  20. Isomonodromic deformations, generalized Knizhnik-Zamolodchikov equations and non-skew-symmetric classical r-matrices

    NASA Astrophysics Data System (ADS)

    Skrypnyk, T.

    2010-08-01

    Using non-skew-symmetric classical r-matrices r12(u,v) with spectral parameters, we generalize Fuchsian systems and Schlesinger equations (isomonodromy equations) viewing the last as the nonautonomous Hamiltonian equations corresponding to the generalized Gaudin Hamiltonians. Quantizing these systems we construct generalization of Knizhnik-Zamolodchikov equations corresponding to the non-skew-symmetric classical r-matrices r12(u,v) with spectral parameters. In the case of an ordinary skew-symmetric classical r-matrix r12(u-v) depending on the difference of the spectral parameters, we reobtain, as special partial cases, a standard generalization of Fuchsian systems, Schlesinger, and Knizhnik-Zamolodchikov equations.

  1. Random Regression Models Based On The Skew Elliptically Contoured Distribution Assumptions With Applications To Longitudinal Data *

    PubMed Central

    Zheng, Shimin; Rao, Uma; Bartolucci, Alfred A.; Singh, Karan P.

    2011-01-01

    Bartolucci et al.(2003) extended the distribution assumption from the normal (Lyles et al., 2000) to the elliptical contoured distribution (ECD) for random regression models used in analysis of longitudinal data accounting for both undetectable values and informative drop-outs. In this paper, the random regression models are constructed on the multivariate skew ECD. A real data set is used to illustrate that the skew ECDs can fit some unimodal continuous data better than the Gaussian distributions or more general continuous symmetric distributions when the symmetric distribution assumption is violated. Also, a simulation study is done for illustrating the model fitness from a variety of skew ECDs. The software we used is SAS/STAT, V. 9.13. PMID:21637734

  2. Separating the effects of mutation and selection in producing DNA skew in bacterial chromosomes

    PubMed Central

    Morton, Richard A; Morton, Brian R

    2007-01-01

    Background Many bacterial chromosomes display nucleotide asymmetry, or skew, between the leading and lagging strands of replication. Mutational differences between these strands result in an overall pattern of skew that is centered about the origin of replication. Such a pattern could also arise from selection coupled with a bias for genes coded on the leading strand. The relative contributions of selection and mutation in producing compositional skew are largely unknown. Results We describe a model to quantify the contribution of mutational differences between the leading and lagging strands in producing replication-induced skew. When the origin and terminus of replication are known, the model can be used to estimate the relative accumulation of G over C and of A over T on the leading strand due to replication effects in a chromosome with bidirectional replication arms. The model may also be implemented in a maximum likelihood framework to estimate the locations of origin and terminus. We find that our estimations for the origin and terminus agree very well with the location of genes that are thought to be associated with the replication origin. This indicates that our model provides an accurate, objective method of determining the replication arms and also provides support for the hypothesis that these genes represent an ancestral cluster of origin-associated genes. Conclusion The model has several advantages over other methods of analyzing genome skew. First, it quantifies the role of mutation in generating skew so that its effect on composition, for example codon bias, can be assessed. Second, it provides an objective method for locating origin and terminus, one that is based on chromosome-wide accumulation of leading vs lagging strand nucleotide differences. Finally, the model has the potential to be utilized in a maximum likelihood framework in order to analyze the effect of chromosome rearrangements on nucleotide composition. PMID:17935620

  3. Atypical AT Skew in Firmicute Genomes Results from Selection and Not from Mutation

    PubMed Central

    Charneski, Catherine A.; Honti, Frank; Bryant, Josephine M.

    2011-01-01

    The second parity rule states that, if there is no bias in mutation or selection, then within each strand of DNA complementary bases are present at approximately equal frequencies. In bacteria, however, there is commonly an excess of G (over C) and, to a lesser extent, T (over A) in the replicatory leading strand. The low G+C Firmicutes, such as Staphylococcus aureus, are unusual in displaying an excess of A over T on the leading strand. As mutation has been established as a major force in the generation of such skews across various bacterial taxa, this anomaly has been assumed to reflect unusual mutation biases in Firmicute genomes. Here we show that this is not the case and that mutation bias does not explain the atypical AT skew seen in S. aureus. First, recently arisen intergenic SNPs predict the classical replication-derived equilibrium enrichment of T relative to A, contrary to what is observed. Second, sites predicted to be under weak purifying selection display only weak AT skew. Third, AT skew is primarily associated with largely non-synonymous first and second codon sites and is seen with respect to their sense direction, not which replicating strand they lie on. The atypical AT skew we show to be a consequence of the strong bias for genes to be co-oriented with the replicating fork, coupled with the selective avoidance of both stop codons and costly amino acids, which tend to have T-rich codons. That intergenic sequence has more A than T, while at mutational equilibrium a preponderance of T is expected, points to a possible further unresolved selective source of skew. PMID:21935355

  4. Correction for Rhiel's theory for the range estimator of the coefficient of variation for skewed distributions.

    PubMed

    Rhiel, G Steven

    2010-02-01

    In 2007, Rhiel presented a technique to estimate the coefficient of variation from the range when sampling from skewed distributions. To provide an unbiased estimate, a correction factor (a(n)) for the mean was included. Numerical correction factors for a number of skewed distributions were provided. In a follow-up paper, he provided a proof he claimed showed the correction factor was independent of the mean and standard deviation, making the factors useful as these parameters vary; however, that proof did not establish independence. Herein is a proof which establishes the independence.

  5. Mixed-derivative skewness for high Prandtl and Reynolds numbers in homogeneous isotropic turbulence

    NASA Astrophysics Data System (ADS)

    Briard, Antoine; Gomez, Thomas

    2016-08-01

    The mixed-derivative skewness Suθ of a passive scalar field in high Reynolds and Prandtl numbers decaying homogeneous isotropic turbulence is studied numerically using eddy-damped quasi-normal Markovian closure, for Reλ ≥ 103 up to Pr = 105. A convergence of Suθ for Pr ≥ 103 is observed for any high enough Reynolds number. This asymptotic high Pr regime can be interpreted as a saturation of the mixing properties of the flow at small scales. The decay of the derivative skewnesses from high to low Reynolds numbers and the influence of large scales initial conditions are investigated as well.

  6. Multivariate skew- t approach to the design of accumulation risk scenarios for the flooding hazard

    NASA Astrophysics Data System (ADS)

    Ghizzoni, Tatiana; Roth, Giorgio; Rudari, Roberto

    2010-10-01

    The multivariate version of the skew- t distribution provides a powerful analytical description of the joint behavior of multivariate processes. It enjoys valuable properties: from the aptitude to model skewed as well as leptokurtic datasets to the availability of moments and likelihood analytical expressions. Moreover, it offers a wide range of extremal dependence strength, allowing for upper and lower tail dependence. The idea underneath this work is to employ the multivariate skew- t distribution to provide an estimation of the joint probability of flood events in a multi-site multi-basin approach. This constitutes the basis for the design and evaluation of flood hazard scenarios for large areas in terms of their intensity, extension and frequency, i.e. those information required by civil protection agencies to put in action mitigation strategies and by insurance companies to price the flooding risk and to evaluate portfolios. Performances of the skew- t distribution and the corresponding t copula function, introduced to represent the state of the art for multivariate simulations, are discussed with reference to the Tanaro Basin, North-western Italy. To enhance the characteristics of the correlation structure, three nested and non-nested gauging stations are selected with contributing areas from 1500 to 8000 km 2. A dataset of 76 trivariate flood events is extracted from a mean daily discharges database available for the time period from January 1995 to December 2003. Applications include the generation of multivariate skew- t and t copula samples and models' comparison through the principle of minimum cross-entropy, here revised for the application to multivariate samples. Copula and skew- t based scenario return period estimations are provided for the November 1994 flood event, i.e. the worst on record in the 1801-2001 period. Results are encouraging: the skew- t distribution seems able to describe the joint behavior, being close to the observations. Marginal

  7. Alternating skew deviation in association with anti-glutamic acid decarboxylase antibodies

    PubMed Central

    Farooq, Asim V.; Soin, Ketki; Moss, Heather E.

    2015-01-01

    The presence of an elevated anti-glutamic acid decarboxylase (GAD) antibody level has been associated with a number of eye movement abnormalities, as well as other findings including cerebellar ataxia and insulin dependent diabetes mellitus. Skew deviation in association with anti-GAD antibodies has not been previously reported. Here we report a case of alternating skew deviation along with cerebellar-brainstem signs in a patient with an elevated anti-GAD antibody titer. Follow-up neurologic evaluation after treatment with intravenous immunoglobulin revealed improvement in cerebellar-brainstem signs, while ophthalmic evaluation was stable. PMID:26594078

  8. An analytical algorithm for skew-slit imaging geometry with nonuniform attenuation correction

    SciTech Connect

    Huang Qiu; Zeng, Gengsheng L.

    2006-04-15

    The pinhole collimator is currently the collimator of choice in small animal single photon emission computed tomography (SPECT) imaging because it can provide high spatial resolution and reasonable sensitivity when the animal is placed very close to the pinhole. It is well known that if the collimator rotates around the object (e.g., a small animal) in a circular orbit to form a cone-beam imaging geometry with a planar trajectory, the acquired data are not sufficient for an exact artifact-free image reconstruction. In this paper a novel skew-slit collimator is mounted instead of the pinhole collimator in order to significantly reduce the image artifacts caused by the geometry. The skew-slit imaging geometry is a more generalized version of the pinhole imaging geometry. The multiple pinhole geometry can also be extended to the multiple-skew-slit geometry. An analytical algorithm for image reconstruction based on the tilted fan-beam inversion is developed with nonuniform attenuation compensation. Numerical simulation shows that the axial artifacts are evidently suppressed in the skew-slit images compared to the pinhole images and the attenuation correction is effective.

  9. Using social parasitism to test reproductive skew models in a primitively eusocial wasp.

    PubMed

    Green, Jonathan P; Cant, Michael A; Field, Jeremy

    2014-08-22

    Remarkable variation exists in the distribution of reproduction (skew) among members of cooperatively breeding groups, both within and between species. Reproductive skew theory has provided an important framework for understanding this variation. In the primitively eusocial Hymenoptera, two models have been routinely tested: concessions models, which assume complete control of reproduction by a dominant individual, and tug-of-war models, which assume on-going competition among group members over reproduction. Current data provide little support for either model, but uncertainty about the ability of individuals to detect genetic relatedness and difficulties in identifying traits conferring competitive ability mean that the relative importance of concessions versus tug-of-war remains unresolved. Here, we suggest that the use of social parasitism to generate meaningful variation in key social variables represents a valuable opportunity to explore the mechanisms underpinning reproductive skew within the social Hymenoptera. We present a direct test of concessions and tug-of-war models in the paper wasp Polistes dominulus by exploiting pronounced changes in relatedness and power structures that occur following replacement of the dominant by a congeneric social parasite. Comparisons of skew in parasitized and unparasitized colonies are consistent with a tug-of-war over reproduction within P. dominulus groups, but provide no evidence for reproductive concessions.

  10. The curious anomaly of skewed judgment distributions and systematic error in the wisdom of crowds.

    PubMed

    Nash, Ulrik W

    2014-01-01

    Judgment distributions are often skewed and we know little about why. This paper explains the phenomenon of skewed judgment distributions by introducing the augmented quincunx (AQ) model of sequential and probabilistic cue categorization by neurons of judges. In the process of developing inferences about true values, when neurons categorize cues better than chance, and when the particular true value is extreme compared to what is typical and anchored upon, then populations of judges form skewed judgment distributions with high probability. Moreover, the collective error made by these people can be inferred from how skewed their judgment distributions are, and in what direction they tilt. This implies not just that judgment distributions are shaped by cues, but that judgment distributions are cues themselves for the wisdom of crowds. The AQ model also predicts that judgment variance correlates positively with collective error, thereby challenging what is commonly believed about how diversity and collective intelligence relate. Data from 3053 judgment surveys about US macroeconomic variables obtained from the Federal Reserve Bank of Philadelphia and the Wall Street Journal provide strong support, and implications are discussed with reference to three central ideas on collective intelligence, these being Galton's conjecture on the distribution of judgments, Muth's rational expectations hypothesis, and Page's diversity prediction theorem. PMID:25406078

  11. Large-scale age-dependent skewed sex ratio in a sexually dimorphic avian scavenger.

    PubMed

    Lambertucci, Sergio A; Carrete, Martina; Donázar, José Antonio; Hiraldo, Fernando

    2012-01-01

    Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus) is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females). By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed.

  12. Large-Scale Age-Dependent Skewed Sex Ratio in a Sexually Dimorphic Avian Scavenger

    PubMed Central

    Lambertucci, Sergio A.; Carrete, Martina; Donázar, José Antonio; Hiraldo, Fernando

    2012-01-01

    Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus) is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females). By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed. PMID:23029488

  13. On Some Confidence Intervals for Estimating the Mean of a Skewed Population

    ERIC Educational Resources Information Center

    Shi, W.; Kibria, B. M. Golam

    2007-01-01

    A number of methods are available in the literature to measure confidence intervals. Here, confidence intervals for estimating the population mean of a skewed distribution are considered. This note proposes two alternative confidence intervals, namely, Median t and Mad t, which are simple adjustments to the Student's t confidence interval. In…

  14. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization

    PubMed Central

    Tan, Kun; An, Lei; Miao, Kai; Ren, Likun; Hou, Zhuocheng; Tao, Li; Zhang, Zhenni; Wang, Xiaodong; Xia, Wei; Liu, Jinghao; Wang, Zhuqing; Xi, Guangyin; Gao, Shuai; Sui, Linlin; Zhu, De-Sheng; Wang, Shumin; Wu, Zhonghong; Bach, Ingolf; Chen, Dong-bao; Tian, Jianhui

    2016-01-01

    Dynamic epigenetic reprogramming occurs during normal embryonic development at the preimplantation stage. Erroneous epigenetic modifications due to environmental perturbations such as manipulation and culture of embryos during in vitro fertilization (IVF) are linked to various short- or long-term consequences. Among these, the skewed sex ratio, an indicator of reproductive hazards, was reported in bovine and porcine embryos and even human IVF newborns. However, since the first case of sex skewing reported in 1991, the underlying mechanisms remain unclear. We reported herein that sex ratio is skewed in mouse IVF offspring, and this was a result of female-biased peri-implantation developmental defects that were originated from impaired imprinted X chromosome inactivation (iXCI) through reduced ring finger protein 12 (Rnf12)/X-inactive specific transcript (Xist) expression. Compensation of impaired iXCI by overexpression of Rnf12 to up-regulate Xist significantly rescued female-biased developmental defects and corrected sex ratio in IVF offspring. Moreover, supplementation of an epigenetic modulator retinoic acid in embryo culture medium up-regulated Rnf12/Xist expression, improved iXCI, and successfully redeemed the skewed sex ratio to nearly 50% in mouse IVF offspring. Thus, our data show that iXCI is one of the major epigenetic barriers for the developmental competence of female embryos during preimplantation stage, and targeting erroneous epigenetic modifications may provide a potential approach for preventing IVF-associated complications. PMID:26951653

  15. Skewing (n +1) Tensor Indices where the Index Range is n

    ERIC Educational Resources Information Center

    Agacy, R. L.

    2005-01-01

    It is known that any totally skew quantity with (n + 1) indices, each of which ranges over n values, vanishes identically. The aim of this short note is to show that this is equivalent to the simple fact that any (n + 1) vectors in an n-dimensional vector space are linearly dependent.

  16. A Monte Carlo Study of Skewed Theta Distributions on DIF Indices.

    ERIC Educational Resources Information Center

    Monaco, Malina

    The effects of skewed theta distributions on indices of differential item functioning (DIF) were studied, comparing Mantel Haenszel (N. Mantel and W. Haenszel, 1959) and DFIT (N. S. Raju, W. J. van der Linden, and P. F. Fleer) (noncompensatory DIF). The significance of the study is that in educational and psychological data, the distributions one…

  17. Bayesian Comparison of GARCH Processes with Skewness Mechanism in Conditional Distributions

    NASA Astrophysics Data System (ADS)

    Pipien, M.

    2006-11-01

    The main goal of this paper is an application of Bayesian model comparison, based on the posterior probabilities and posterior odds ratios, in testing the explanatory power of a set of competing GARCH (Generalized Autoregressive Conditionally Heteroscedastic) specifications, all with asymmetric and heavy tailed conditional distributions. In building competing volatility models we consider, as an initial specification, conditionally Student-t GARCH process with unknown degrees of freedom parameter. By introducing skewness into Student-t family and incorporating the resulting class as a conditional distribution we generated various GARCH models, which compete in explaining possible asymmetry of both conditional and unconditional distribution of financial data. In order to make Student-t family skewed we consider various alternative mechanisms recently proposed in the literature. In particular, we apply the hidden truncation mechanism, an approach based on the inverse scale factors in the positive and the negative orthant, order statistics concept, Beta distribution transformation and Bernstein density transformation. Additionally, we consider GARCH process with conditional alpha -Stable distribution. Based on the daily returns of hypothetical financial time series, we discuss the results of Bayesian comparison of alternative skewing mechanisms applied in the initial Student-t GARCH framework. Additionally, we present formal Bayesian inference about conditional asymmetry of the distribution of the daily returns in all competing specifications on the basis of the skewness measure defined by Arnold and Groenveld.

  18. The Curious Anomaly of Skewed Judgment Distributions and Systematic Error in the Wisdom of Crowds

    PubMed Central

    Nash, Ulrik W.

    2014-01-01

    Judgment distributions are often skewed and we know little about why. This paper explains the phenomenon of skewed judgment distributions by introducing the augmented quincunx (AQ) model of sequential and probabilistic cue categorization by neurons of judges. In the process of developing inferences about true values, when neurons categorize cues better than chance, and when the particular true value is extreme compared to what is typical and anchored upon, then populations of judges form skewed judgment distributions with high probability. Moreover, the collective error made by these people can be inferred from how skewed their judgment distributions are, and in what direction they tilt. This implies not just that judgment distributions are shaped by cues, but that judgment distributions are cues themselves for the wisdom of crowds. The AQ model also predicts that judgment variance correlates positively with collective error, thereby challenging what is commonly believed about how diversity and collective intelligence relate. Data from 3053 judgment surveys about US macroeconomic variables obtained from the Federal Reserve Bank of Philadelphia and the Wall Street Journal provide strong support, and implications are discussed with reference to three central ideas on collective intelligence, these being Galton's conjecture on the distribution of judgments, Muth's rational expectations hypothesis, and Page's diversity prediction theorem. PMID:25406078

  19. Skew-varicose instability in two-dimensional generalized Swift-Hohenberg equations.

    PubMed

    Weliwita, J A; Rucklidge, A M; Tobias, S M

    2011-09-01

    We apply analytical and numerical methods to study the linear stability of stripe patterns in two generalizations of the two-dimensional Swift-Hohenberg equation that include coupling to a mean flow. A projection operator is included in our models to allow exact stripe solutions. In the generalized models, stripes become unstable to the skew-varicose, oscillatory skew-varicose, and cross-roll instabilities, in addition to the usual Eckhaus and zigzag instabilities. We analytically derive stability boundaries for the skew-varicose instability in various cases, including several asymptotic limits. We also use numerical techniques to determine eigenvalues and hence stability boundaries of other instabilities. We extend our analysis to both stress-free and no-slip boundary conditions and we note a crossover from the behavior characteristic of no-slip to that of stress-free boundaries as the coupling to the mean flow increases or as the Prandtl number decreases. Close to the critical value of the bifurcation parameter, the skew-varicose instability has the same curvature as the Eckhaus instability provided the coupling to the mean flow is greater than a critical value. The region of stable stripes is completely eliminated by the cross-roll instability for large coupling to the mean flow.

  20. Large-scale age-dependent skewed sex ratio in a sexually dimorphic avian scavenger.

    PubMed

    Lambertucci, Sergio A; Carrete, Martina; Donázar, José Antonio; Hiraldo, Fernando

    2012-01-01

    Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus) is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females). By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed. PMID:23029488

  1. Skew angle effects in shingled magnetic recording system with double/triple reader head array

    NASA Astrophysics Data System (ADS)

    Elidrissi, Moulay Rachid; Sann Chan, Kheong; Greaves, Simon; Kanai, Yasushi; Muraoka, Hiroaki

    2014-05-01

    Shingled Magnetic Recording (SMR) is a scheme used to extend the life of the current perpendicular magnetic recording technology. SMR enables writing narrow tracks with a wide writer. Currently, SMR employs a single reader and will suffer inter-track interference (ITI) as the tracks become comparable in width to the reader. ITI can be mitigated by using narrower readers; however, narrower readers suffer from increased reader noise. Another approach to combat ITI is to process 2D readback and use ITI cancellation schemes to retrieve the data track. Multiple readbacks can be obtained either with a single reader and multiple revolutions or with a reader array. The former suffers from increased readback latency. In this work, we focus on the latter. When using a reader array, the skew angle poses major challenges. During writing, there is increased adjacent track erasure, and during readback the effective reader pitch varies and there is an increase in the 2D intersymbol interference caused by the rotated reader profile. In this work, we run micromagnetic simulations at different skew angles to train the grain flipping probability model, and then evaluate raw bit channel error rate performance at skew. In particular, we investigate the performance degradation caused by skewing of the 2 or 3 read head array for various read-head geometries.

  2. Numerical solution for the velocity-derivative skewness of a low-Reynolds-number decaying Navier-Stokes flow

    NASA Technical Reports Server (NTRS)

    Deissler, Robert G.

    1990-01-01

    The variation of the velocity-derivative skewness of a Navier-Stokes flow as the Reynolds number goes toward zero is calculated numerically. The value of the skewness, which has been somewhat controversial, is shown to become small at low Reynolds numbers.

  3. Reproductive skew and relatedness in social groups of European badgers, Meles meles.

    PubMed

    Dugdale, Hannah L; Macdonald, David W; Pope, Lisa C; Johnson, Paul J; Burke, Terry

    2008-04-01

    Reproductive skew is a measure of the proportion of individuals of each sex that breed in a group and is a valuable measure for understanding the evolution and maintenance of sociality. Here, we provide the first quantification of reproductive skew within social groups of European badgers Meles meles, throughout an 18-year study in a high-density population. We used 22 microsatellite loci to analyse within-group relatedness and demonstrated that badger groups contained relatives. The average within-group relatedness was high (R = 0.20) and approximately one-third of within-group dyads were more likely to represent first-order kin than unrelated pairs. Adult females within groups had higher pairwise relatedness than adult males, due to the high frequency of extra-group paternities, rather than permanent physical dispersal. Spatial clustering of relatives occurred among neighbouring groups, which we suggest was due to the majority of extra-group paternities being attributable to neighbouring males. Reproductive skew was found among within-group candidate fathers (B = 0.26) and candidate mothers (B = 0.07), but not among breeding individuals; our power to detect skew in the latter was low. We use these results to evaluate reproductive skew models. Although badger society best fits the assumptions of the incomplete-control models, our results were not consistent with their predictions. We suggest that this may be due to female control of paternity, female-female reproductive suppression occurring only in years with high food availability resulting in competition over access to breeding sites, extra-group paternity masking the benefits of natal philopatry, and/or the inconsistent occurrence of hierarchies that are linear when established. PMID:18371017

  4. Effects of trophic skewing of species richness on ecosystem functioning in a diverse marine community.

    PubMed

    Reynolds, Pamela L; Bruno, John F

    2012-01-01

    Widespread overharvesting of top consumers of the world's ecosystems has "skewed" food webs, in terms of biomass and species richness, towards a generally greater domination at lower trophic levels. This skewing is exacerbated in locations where exotic species are predominantly low-trophic level consumers such as benthic macrophytes, detritivores, and filter feeders. However, in some systems where numerous exotic predators have been added, sometimes purposefully as in many freshwater systems, food webs are skewed in the opposite direction toward consumer dominance. Little is known about how such modifications to food web topology, e.g., changes in the ratio of predator to prey species richness, affect ecosystem functioning. We experimentally measured the effects of trophic skew on production in an estuarine food web by manipulating ratios of species richness across three trophic levels in experimental mesocosms. After 24 days, increasing macroalgal richness promoted both plant biomass and grazer abundance, although the positive effect on plant biomass disappeared in the presence of grazers. The strongest trophic cascade on the experimentally stocked macroalgae emerged in communities with a greater ratio of prey to predator richness (bottom-rich food webs), while stronger cascades on the accumulation of naturally colonizing algae (primarily microalgae with some early successional macroalgae that recruited and grew in the mesocosms) generally emerged in communities with greater predator to prey richness (the more top-rich food webs). These results suggest that trophic skewing of species richness and overall changes in food web topology can influence marine community structure and food web dynamics in complex ways, emphasizing the need for multitrophic approaches to understand the consequences of marine extinctions and invasions.

  5. Risk-sensitive foraging and the evolution of cooperative breeding and reproductive skew

    PubMed Central

    Poethke, Hans J; Liebig, Jürgen

    2008-01-01

    Background Group formation and food sharing in animals may reduce variance in resource supply to breeding individuals. For some species it has thus been interpreted as a mechanism of risk avoidance. However, in many groups reproduction is extremely skewed. In such groups resources are not shared equally among the members and inter-individual variance in resource supply may be extreme. The potential consequences of this aspect of group living have not attained much attention in the context of risk sensitive foraging. Results We develop a model of individually foraging animals that share resources for reproduction. The model allows analyzing how mean foraging success, inter-individual variance of foraging success, and the cost of reproduction and offspring raising influence the benefit of group formation and resource sharing. Our model shows that the effects are diametrically opposed in egalitarian groups versus groups with high reproductive skew. For individuals in egalitarian groups the relative benefit of group formation increases under conditions of increasing variance in foraging success and decreasing cost of reproduction. On the other hand individuals in groups with high skew will profit from group formation under conditions of decreasing variance in individual foraging success and increasing cost of reproduction. Conclusion The model clearly demonstrates that reproductive skew qualitatively changes the influence of food sharing on the reproductive output of groups. It shows that the individual benefits of variance reduction in egalitarian groups and variance enhancement in groups with reproductive skew depend critically on ecological and life-history parameters. Our model of risk-sensitive foraging thus allows comparing animal societies as different as spiders and birds in a single framework. PMID:18366668

  6. Toward Quantifying the Spreading-Rate Dependence of Anomalous Skewness of Marine Magnetic Anomalies due to Seafloor Spreading

    NASA Astrophysics Data System (ADS)

    Boswell, S. M.; Zheng, L.; Gordon, R. G.; Dyment, J.

    2010-12-01

    In past work, reliable paleomagnetic poles have been determined from skewness data by solving for a single additional adjustable parameter, anomalous skewness, assumed to be independent of spreading rate [Petronotis et al. 1992, 1994; Petronotis & Gordon 1999]. Nonetheless, analysis of anomalies in several ocean basins indicate that anomalous skewness depends on spreading rate for spreading half rates less than ≈50 mm/yr [Roest et al., 1992; Dyment et al. 1994]. To facilitate investigation of the influence of spreading-rate dependent anomalous skewness on the determination of paleomagnetic poles determined from skewness, we build on the model for marine magnetic anomalies due to seafloor spreading of Dyment and Arkani-Hamed [1995]. We use this model to estimate anomalous skewness as a function of spreading rate for many anomalies. Synthetic magnetic anomaly profiles for oceanic lithosphere with sloping curving reversal boundaries were produced by forward modeling. Anomalous skewness values for chrons 25n to 33r were visually determined at various spreading rates using two approaches: balancing the shoulders of an anomaly corresponding to a single chron and best matching an anomaly corresponding to a single chron to a synthetic anomaly determined assuming vertical reversal boundaries. The new results may facilitate the determination of paleomagnetic poles from less widely distributed crossings of a magnetic anomaly than were used before. Further implications for determination of paleomagnetic poles for the Pacific plate will be discussed.

  7. Construction engineering of steel tub-girder bridge systems for skew effects

    NASA Astrophysics Data System (ADS)

    Jimenez Chong, Juan Manuel

    Closed structural sections, such as those having circular, rectangular or trapezoidal shape, possess high rotational rigidity when compared to open sections such as I-girders. The high torsional rigidity of closed sections makes them ideal for use in highly curved bridges. In this case, the geometry of the bridge results in large torsional forces. Because of structural efficiency and economy reasons, most of these closed-section bridges consist of a trapezoidal cross-section, with a top concrete slab and bottom and side steel plates. The slab is cast after the steel is erected and thus a system of internal diaphragms and braces is necessary to stabilize the system during erection. During the steel erection and the early stages of the concrete deck placement, the section can be considered as quasi-closed as the top concrete flange has not been cast or is not yet effective. During steel erection, undetermined and/or large torsional forces and/or displacements may result in fit-up problems requiring large stresses to overcome. During concrete deck placement, the undetermined displacements can affect the control of the deck thickness and the final deck geometry, such as the alignment of deck joints and the matching of stages in phased constructions projects. Due to the interactions between their various components, the behavior of curved and skewed tub-girder bridges is significantly more complex than that of straight bridges. When skewed supports are used in tub-girders, the interaction of the girder bending rotations and the displacement constraints induced by the skewed support diaphragms causes twisting of the girders at the supports. These twist rotations introduce additional torques into the system. Both curvature and skew can cause design and construction difficulties, especially at the supports, where the corresponding steel dead load deflections and the large torsional stiffness of the girders may lead to large fit-up forces. Currently, the general

  8. Commutative n-ary superalgebras with an invariant skew-symmetric form

    NASA Astrophysics Data System (ADS)

    Vishnyakova, E. G.

    2015-12-01

    We study n-ary commutative superalgebras and L∞-algebras that possess a skew-symmetric invariant form, using the derived bracket formalism. This class of superalgebras includes for instance Lie algebras and their n-ary generalizations, commutative associative and Jordan algebras with an invariant form. We give a classification of anti-commutative m-dimensional (m - 3) -ary algebras with an invariant form, and a classification of real simple m-dimensional Lie (m - 3) -algebras with a positive definite invariant form up to isometry. Furthermore, we develop the Hodge Theory for L∞-algebras with a symmetric invariant form, and we describe quasi-Frobenius structures on skew-symmetric n-ary algebras.

  9. Semiparametric Bayesian inference on skew-normal joint modeling of multivariate longitudinal and survival data.

    PubMed

    Tang, An-Min; Tang, Nian-Sheng

    2015-02-28

    We propose a semiparametric multivariate skew-normal joint model for multivariate longitudinal and multivariate survival data. One main feature of the posited model is that we relax the commonly used normality assumption for random effects and within-subject error by using a centered Dirichlet process prior to specify the random effects distribution and using a multivariate skew-normal distribution to specify the within-subject error distribution and model trajectory functions of longitudinal responses semiparametrically. A Bayesian approach is proposed to simultaneously obtain Bayesian estimates of unknown parameters, random effects and nonparametric functions by combining the Gibbs sampler and the Metropolis-Hastings algorithm. Particularly, a Bayesian local influence approach is developed to assess the effect of minor perturbations to within-subject measurement error and random effects. Several simulation studies and an example are presented to illustrate the proposed methodologies. PMID:25404574

  10. Optimization Of Mean-Semivariance-Skewness Portfolio Selection Model In Fuzzy Random Environment

    NASA Astrophysics Data System (ADS)

    Chatterjee, Amitava; Bhattacharyya, Rupak; Mukherjee, Supratim; Kar, Samarjit

    2010-10-01

    The purpose of the paper is to construct a mean-semivariance-skewness portfolio selection model in fuzzy random environment. The objective is to maximize the skewness with predefined maximum risk tolerance and minimum expected return. Here the security returns in the objectives and constraints are assumed to be fuzzy random variables in nature and then the vagueness of the fuzzy random variables in the objectives and constraints are transformed into fuzzy variables which are similar to trapezoidal numbers. The newly formed fuzzy model is then converted into a deterministic optimization model. The feasibility and effectiveness of the proposed method is verified by numerical example extracted from Bombay Stock Exchange (BSE). The exact parameters of fuzzy membership function and probability density function are obtained through fuzzy random simulating the past dates.

  11. Skew Projection of Echo-Detected EPR Spectra for Increased Sensitivity and Resolution

    PubMed Central

    Bowman, Michael K.; Krzyaniak, Matthew D.; Cruce, Alex A.; Weber, Ralph T.

    2013-01-01

    The measurement of EPR spectra during pulsed EPR experiments is commonly accomplished by recording the integral of the electron spin echo as the applied magnetic field is stepped through the spectrum. This approach to echo-detected EPR spectral measurement (ED-EPR) limits sensitivity and spectral resolution and can cause gross distortions in the resulting spectra because some of the information present in the electron spin echo is discarded in such measurements. However, Fourier Transformation of echo shapes measured at a series of magnetic field values followed by skew projection onto either a magnetic field or resonance frequency axis can increase both spectral resolution and sensitivity without the need to trade one against the other. Examples of skew-projected spectra with single crystals, glasses and powders show resolution improvements as large as a factor of seven with sensitivity increases of as much as a factor of five. PMID:23644351

  12. Skewed X-chromosome inactivation in women affected by Alzheimer's disease.

    PubMed

    Bajic, Vladan; Mandusic, Vesna; Stefanova, Elka; Bozovic, Ana; Davidovic, Radoslav; Zivkovic, Lada; Cabarkapa, Andrea; Spremo-Potparevic, Biljana

    2015-01-01

    X-chromosome instability has been a long established feature in Alzheimer's disease (AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes of women affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes of women with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women. PMID:25159673

  13. Muon Tracking Studies in a Skew Parametric Resonance Ionization Cooling Channel

    SciTech Connect

    Sy, Amy; Afanaciev, Andre; Derbenev, Yaroslav S.; Johnson, Rolland; Morozov, Vasiliy

    2015-09-01

    Skew Parametric-resonance Ionization Cooling (SPIC) is an extension of the Parametric-resonance Ionization Cooling (PIC) framework that has previously been explored as the final 6D cooling stage of a high-luminosity muon collider. The addition of skew quadrupoles to the PIC magnetic focusing channel induces coupled dynamic behavior of the beam that is radially periodic. The periodicity of the radial motion allows for the avoidance of unwanted resonances in the horizontal and vertical transverse planes, while still providing periodic locations at which ionization cooling components can be implemented. A first practical implementation of the magnetic field components required in the SPIC channel is modeled in MADX. Dynamic features of the coupled correlated optics with and without induced parametric resonance are presented and discussed.

  14. Skew-Quad Parametric-Resonance Ionization Cooling: Theory and Modeling

    SciTech Connect

    Afanaciev, Andre; Derbenev, Yaroslav S.; Morozov, Vasiliy; Sy, Amy; Johnson, Rolland P.

    2015-09-01

    Muon beam ionization cooling is a key component for the next generation of high-luminosity muon colliders. To reach adequately high luminosity without excessively large muon intensities, it was proposed previously to combine ionization cooling with techniques using a parametric resonance (PIC). Practical implementation of PIC proposal is a subject of this report. We show that an addition of skew quadrupoles to a planar PIC channel gives enough flexibility in the design to avoid unwanted resonances, while meeting the requirements of radially-periodic beam focusing at ionization-cooling plates, large dynamic aperture and an oscillating dispersion needed for aberration corrections. Theoretical arguments are corroborated with models and a detailed numerical analysis, providing step-by-step guidance for the design of Skew-quad PIC (SPIC) beamline.

  15. Truck loading positions for maximum live load girder moment in skewed integral bridges

    NASA Astrophysics Data System (ADS)

    Yalcin, O. Fatih

    2015-12-01

    In this study, the effect of the longitudinal and transverse truck positions on the distribution of live load moment among the girders of skewed integral abutment bridges (SIBs) is investigated. For this purpose, three dimensional finite element models (FEMs) of several single-span SIBs are built and analyzed. In the analyses, bridges with various skew angles under all possible single and double truck loading positions both in longitudinal and transverse directions are considered. An automated analysis procedure managed by a visual basic program is developed to obtain the structural models and apply the wheel loads of trucks. The finite element analyses (FEA) results are then used to find the most critical loading cases of single truck and adjacent two trucks for the live load moment in the girders of SIBs. The results revealed that, the trucks should be placed nearby the midline of the bridge deck in a diagonal manner.

  16. Surveying and optical tooling technologies combined to align a skewed beamline at the LAMPF accelerator

    SciTech Connect

    Bauke, W.; Clark, D.A.; Trujillo, P.B.

    1985-01-01

    Optical Tooling evolved from traditional surveying, and both technologies are sometimes used interchangeably in large industrial installations, since the instruments and their specialized adapters and supports complement each other well. A unique marriage of both technologies was accomplished in a novel application at LAMPF, the Los Alamos Meson Physics Facility. LAMPF consists of a linear accelerator with multiple target systems, one of which had to be altered to accommodate a new beamline for a neutrino experiment. The new line was to be installed into a crowded beam tunnel and had to be skewed and tilted in compound angles to avoid existing equipment. In this paper we describe how Optical Tooling was used in conjunction with simple alignment and reference fixtures to set fiducials on the magnets and other mechanical components of the beamline, and how theodolites and sight levels were then adapted to align these components along the calculated skew planes. Design tolerances are compared with measured alignment results.

  17. Kinetic investigation of the extrinsic spin Hall effect induced by skew scattering

    NASA Astrophysics Data System (ADS)

    Cheng, J. L.; Wu, M. W.

    2008-02-01

    A study of the kinetics of the extrinsic spin Hall conductivity induced by skew scattering is performed using the fully microscopic kinetic spin Bloch equation approach to the (001) GaAs symmetric quantum well. In the steady state, the extrinsic spin Hall current/conductivity vanishes for the linear k dependent spin-orbit coupling and is very small for the cubic k dependent spin-orbit coupling. The spin precession induced by the Dresselhaus/Rashba spin-orbit coupling plays a very important role in the vanishing of the extrinsic spin Hall conductivity in the steady state. An in-plane spin polarization is induced by the skew scattering, with the help of the spin-orbit coupling. This spin polarization is very different from the current-induced spin polarization.

  18. Research on the optimal structure configuration of dither RLG used in skewed redundant INS

    NASA Astrophysics Data System (ADS)

    Gao, Chunfeng; Wang, Qi; Wei, Guo; Long, Xingwu

    2016-05-01

    The actual combat effectiveness of weapon equipment is restricted by the performance of Inertial Navigation System (INS), especially in high reliability required situations such as fighter, satellite and submarine. Through the use of skewed sensor geometries, redundant technique has been applied to reduce the cost and improve the reliability of the INS. In this paper, the structure configuration and the inertial sensor characteristics of Skewed Redundant Strapdown Inertial Navigation System (SRSINS) using dithered Ring Laser Gyroscope (RLG) are analyzed. For the dither coupling effects of the dither gyro, the system measurement errors can be amplified either the individual gyro dither frequency is near one another or the structure of the SRSINS is unreasonable. Based on the characteristics of RLG, the research on coupled vibration of dithered RLG in SRSINS is carried out. On the principle of optimal navigation performance, optimal reliability and optimal cost-effectiveness, the comprehensive evaluation scheme of the inertial sensor configuration of SRINS is given.

  19. Olfactory learning skews mushroom body output pathways to steer behavioral choice in Drosophila

    PubMed Central

    Owald, David; Waddell, Scott

    2015-01-01

    Learning permits animals to attach meaning and context to sensory stimuli. How this information is coded in neural networks in the brain, and appropriately retrieved and utilized to guide behavior, is poorly understood. In the fruit fly olfactory memories of particular value are represented within sparse populations of odor-activated Kenyon cells (KCs) in the mushroom body ensemble. During learning reinforcing dopaminergic neurons skew the mushroom body network by driving zonally restricted plasticity at synaptic junctions between the KCs and subsets of the overall small collection of mushroom body output neurons. Reactivation of this skewed KC-output neuron network retrieves memory of odor valence and guides appropriate approach or avoidance behavior. PMID:26496148

  20. Permanent Magnet Skew Quadrupoles for the Low Emittance LER Lattice of PEP-II

    SciTech Connect

    Decker, F.-J.; Anderson, S.; Kharakh, D.; Sullivan, M.; /SLAC

    2011-07-05

    The vertical emittance of the low energy ring (LER) in the PEP-II B-Factory was reduced by using skew quadrupoles consisting of permanent magnet material. The advantages over electric quadrupoles or rotating existing normal quadrupoles are discussed. To assure a high field quality, a Biot-Savart calculation was used to cancel the natural 12-pole component by using different size poles over a few layers. A magnetic measurement confirmed the high quality of the magnets. After installation and adjusting the original electric 12 skew and 16 normal quadrupoles the emittance contribution from the region close to the interaction point, which was the biggest part in the original design, was considerably reduced. To strengthen the vertical behavior of the LER beam, a low emittance lattice was developed. It lowered the original vertical design emittance from 0.54 nm-rad to 0.034 nm-rad. In order to achieve this, additional skew quadrupoles were required to bring the coupling correction out of the arcs and closer to the detector solenoid in the straight (Fig. 1). It is important, together with low vertical dispersion, that the low vertical emittance is not coupled into the horizontal, which is what we get if the coupling correction continues into the arcs. Further details of the lattice work is described in another paper; here we concentrate on the development of the permanent skew (PSK) quadrupole solution. Besides the permanent magnets there are two other possibilities, using electric magnets or rotating normal quadrupoles. Electric magnets would have required much more additional equipment like magnets stands, power supply, and new vacuum chamber sections. Rotating existing quadrupoles was also not feasible since they are mostly mounted together with a bending magnet on the same support girder.

  1. Skewness-induced asymmetric modulation of small-scale turbulence by large-scale structures

    NASA Astrophysics Data System (ADS)

    Agostini, Lionel; Leschziner, Michael; Gaitonde, Datta

    2016-01-01

    Several recent studies discuss of role of skewness of the turbulent velocity fluctuations in near-wall shear layers, in the context of quantifying the correlation between large-scale motions and amplitude variations of small-scale fluctuations—referred to as "modulation." The present study is based on the premise that the skewness of the small-scale fluctuations should be accounted for explicitly in the process of defining their envelope, which characterizes their amplitude variations. This leads to the notion of two envelopes, one for positive and the other for negative small-scale fluctuations, and hence also to two corresponding correlation coefficients. Justification for this concept is provided first by an examination of a high-frequency synthetic signal subjected to realistic skewness-inducing modulation. A new formalism is provided for deriving the two envelopes, and its fidelity is demonstrated for the synthetic test case. The method is then applied to a channel flow at a friction Reynolds number of 4200, for which direct numerical simulation (DNS) data are available. The large-scale and small-scale fields are separated by the empirical mode decomposition method, and the modulation of the small-scale fluctuations by the large scales is examined. Separate maps of the correlation coefficient and of two-point correlations, the latter linking the large-scale motions and the envelopes of the small-scale motions, are derived for the two envelopes pertaining to positive and negative small-scale fluctuations, and these demonstrate a significant sensitivity to the envelope-definition process, especially close to the wall where the skewness of the small-scale fluctuations is the dominant contributor to the total value.

  2. Measuring skewness of red blood cell deformability distribution by laser ektacytometry

    SciTech Connect

    Nikitin, S Yu; Priezzhev, A V; Lugovtsov, A E; Ustinov, V D

    2014-08-31

    An algorithm is proposed for measuring the parameters of red blood cell deformability distribution based on laser diffractometry of red blood cells in shear flow (ektacytometry). The algorithm is tested on specially prepared samples of rat blood. In these experiments we succeeded in measuring the mean deformability, deformability variance and skewness of red blood cell deformability distribution with errors of 10%, 15% and 35%, respectively. (laser biophotonics)

  3. Effects of Trophic Skewing of Species Richness on Ecosystem Functioning in a Diverse Marine Community

    PubMed Central

    Reynolds, Pamela L.; Bruno, John F.

    2012-01-01

    Widespread overharvesting of top consumers of the world’s ecosystems has “skewed” food webs, in terms of biomass and species richness, towards a generally greater domination at lower trophic levels. This skewing is exacerbated in locations where exotic species are predominantly low-trophic level consumers such as benthic macrophytes, detritivores, and filter feeders. However, in some systems where numerous exotic predators have been added, sometimes purposefully as in many freshwater systems, food webs are skewed in the opposite direction toward consumer dominance. Little is known about how such modifications to food web topology, e.g., changes in the ratio of predator to prey species richness, affect ecosystem functioning. We experimentally measured the effects of trophic skew on production in an estuarine food web by manipulating ratios of species richness across three trophic levels in experimental mesocosms. After 24 days, increasing macroalgal richness promoted both plant biomass and grazer abundance, although the positive effect on plant biomass disappeared in the presence of grazers. The strongest trophic cascade on the experimentally stocked macroalgae emerged in communities with a greater ratio of prey to predator richness (bottom-rich food webs), while stronger cascades on the accumulation of naturally colonizing algae (primarily microalgae with some early successional macroalgae that recruited and grew in the mesocosms) generally emerged in communities with greater predator to prey richness (the more top-rich food webs). These results suggest that trophic skewing of species richness and overall changes in food web topology can influence marine community structure and food web dynamics in complex ways, emphasizing the need for multitrophic approaches to understand the consequences of marine extinctions and invasions. PMID:22693549

  4. Detection of microscopic defects in optical fiber coatings using angle-resolved skew rays.

    PubMed

    Chen, George Y; Monro, Tanya M; Lancaster, David G

    2016-09-01

    Microscopic defects in optical fiber coatings can be an impending catastrophe for high-power fiber laser and telecommunications systems and are difficult to detect with conventional methods. We demonstrate a highly sensitive interrogation technique that can readily identify faults such as microscopic nicks, scrapes, low-quality recoatings, and internal defects in fibers and their coatings, based on skew ray excitation and angle-resolved analysis.

  5. Detection of microscopic defects in optical fiber coatings using angle-resolved skew rays.

    PubMed

    Chen, George Y; Monro, Tanya M; Lancaster, David G

    2016-09-01

    Microscopic defects in optical fiber coatings can be an impending catastrophe for high-power fiber laser and telecommunications systems and are difficult to detect with conventional methods. We demonstrate a highly sensitive interrogation technique that can readily identify faults such as microscopic nicks, scrapes, low-quality recoatings, and internal defects in fibers and their coatings, based on skew ray excitation and angle-resolved analysis. PMID:27607966

  6. Reproductive skew drives patterns of sexual dimorphism in sponge-dwelling snapping shrimps.

    PubMed

    Chak, Solomon Tin Chi; Duffy, J Emmett; Rubenstein, Dustin R

    2015-06-22

    Sexual dimorphism is typically a result of strong sexual selection on male traits used in male-male competition and subsequent female choice. However, in social species where reproduction is monopolized by one or a few individuals in a group, selection on secondary sexual characteristics may be strong in both sexes. Indeed, sexual dimorphism is reduced in many cooperatively breeding vertebrates and eusocial insects with totipotent workers, presumably because of increased selection on female traits. Here, we examined the relationship between sexual dimorphism and sociality in eight species of Synalpheus snapping shrimps that vary in social structure and degree of reproductive skew. In species where reproduction was shared more equitably, most members of both sexes were physiologically capable of breeding. However, in species where reproduction was monopolized by a single individual, a large proportion of females--but not males--were reproductively inactive, suggesting stronger reproductive suppression and conflict among females. Moreover, as skew increased across species, proportional size of the major chela--the primary antagonistic weapon in snapping shrimps--increased among females and sexual dimorphism in major chela size declined. Thus, as reproductive skew increases among Synalpheus, female-female competition over reproduction appears to increase, resulting in decreased sexual dimorphism in weapon size.

  7. Reproductive skew drives patterns of sexual dimorphism in sponge-dwelling snapping shrimps

    PubMed Central

    Chak, Solomon Tin Chi; Duffy, J. Emmett; Rubenstein, Dustin R.

    2015-01-01

    Sexual dimorphism is typically a result of strong sexual selection on male traits used in male–male competition and subsequent female choice. However, in social species where reproduction is monopolized by one or a few individuals in a group, selection on secondary sexual characteristics may be strong in both sexes. Indeed, sexual dimorphism is reduced in many cooperatively breeding vertebrates and eusocial insects with totipotent workers, presumably because of increased selection on female traits. Here, we examined the relationship between sexual dimorphism and sociality in eight species of Synalpheus snapping shrimps that vary in social structure and degree of reproductive skew. In species where reproduction was shared more equitably, most members of both sexes were physiologically capable of breeding. However, in species where reproduction was monopolized by a single individual, a large proportion of females—but not males—were reproductively inactive, suggesting stronger reproductive suppression and conflict among females. Moreover, as skew increased across species, proportional size of the major chela—the primary antagonistic weapon in snapping shrimps—increased among females and sexual dimorphism in major chela size declined. Thus, as reproductive skew increases among Synalpheus, female–female competition over reproduction appears to increase, resulting in decreased sexual dimorphism in weapon size. PMID:26041357

  8. A QTL Study for Regions Contributing to Arabidopsis thaliana Root Skewing on Tilted Surfaces.

    PubMed

    Vaughn, Laura M; Masson, Patrick H

    2011-07-01

    Plant root systems must grow in a manner that is dictated by endogenous genetic pathways, yet sensitive to environmental input. This allows them to provide the plant with water and nutrients while navigating a heterogeneous soil environment filled with obstacles, toxins, and pests. Gravity and touch, which constitute important cues for roots growing in soil, have been shown to modulate root architecture by altering growth patterns. This is illustrated by Arabidopsis thaliana roots growing on tilted hard agar surfaces. Under these conditions, the roots are exposed to both gravity and touch stimulation. Consequently, they tend to skew their growth away from the vertical and wave along the surface. This complex growth behavior is believed to help roots avoid obstacles in nature. Interestingly, A. thaliana accessions display distinct growth patterns under these conditions, suggesting the possibility of using this variation as a tool to identify the molecular mechanisms that modulate root behavior in response to their mechanical environment. We have used the Cvi/Ler recombinant inbred line population to identify quantitative trait loci that contribute to root skewing on tilted hard agar surfaces. A combination of fine mapping for one of these QTL and microarray analysis of expression differences between Cvi and Ler root tips identifies a region on chromosome 2 as contributing to root skewing on tilted surfaces, potentially by modulating cell wall composition.

  9. Stress Analysis of a New Disk-Type Variable Torque Slipping Clutch with Skewed Rollers

    NASA Astrophysics Data System (ADS)

    Feng, Ming; Ono, Kyosuke; Mimura, Kenji

    In this paper a new disk type of the variable torque slipping clutch with skewed rollers (VTSCSR) is presented and investigated both theoretically and experimentally. It is comprised of two flat disks, a number of skewed cylindrical rollers, and a cage. The slipping torque is produced by the skewed rollers rolling and slipping between the two disks. Based on the integral equation of the Boussinesq solution, the contact pressures are numerically calculated under the condition that the nonlinear equilibrium equations of the clutch elements are satisfied. By considering both pressure and friction, the components of subsurface stress are calculated from the integration of the Mindlin's subsurface stress equations of concentrated force. A numerical solver is then successfully developed by which the characteristics of the disk-type VTSCSR, including the torque capacity, angular velocities of the roller and cage, contact pressure and von Mises stress, etc, are calculated and illustrated for the typical designs. The influences on the distribution of the von Mises stress by applying various types of profiled rollers to the disk-type VTSCSR are also discussed. It has been found that the full crown with two arcs profiled roller can approximately give rise to the axially uniform distribution of the von Mises stress and therefore satisfies the design principle of the average damage of materials. In addition, the preliminary experiment was done in order to show the feasibility of this design idea and to verify the theoretical torque capacity.

  10. An inconvenient sea truth: spread, steepness, and skewness of surface slopes.

    PubMed

    Munk, Walter

    2009-01-01

    Bréon and Henriot (BH) have collected eight million globally distributed satellite images of sunglitter, which yield a few simple, robust rules about the statistics of surface slopes: 1) constant angular spread, 2) linear steepness, and 3) sigmoid (near stepwise) skewness (all with respect to wind speed). Yet the information is sparse because it says nothing about time and space scales. The BH rules are an inconvenient sea truth, too fundamental to be ignored, too incomplete to be understood. With regard to BH rule 1 (BH:1), I suggest that the constant spread is associated with a wake-like geometry of the short gravities. Steepness linearity (BH:2) remains an enigma. Skewness (BH:3) appears to be correlated with a rather sudden onset of breaking for winds above 4 m s(-1). I do not think that skewness comes from parasitic capillaries. These are tentative conclusions; I look forward to intensive sea-going experiments over the next few years demolishing the proposed interpretations.

  11. A Bayesian estimate of the concordance correlation coefficient with skewed data.

    PubMed

    Feng, Dai; Baumgartner, Richard; Svetnik, Vladimir

    2015-01-01

    Concordance correlation coefficient (CCC) is one of the most popular scaled indices used to evaluate agreement. Most commonly, it is used under the assumption that data is normally distributed. This assumption, however, does not apply to skewed data sets. While methods for the estimation of the CCC of skewed data sets have been introduced and studied, the Bayesian approach and its comparison with the previous methods has been lacking. In this study, we propose a Bayesian method for the estimation of the CCC of skewed data sets and compare it with the best method previously investigated. The proposed method has certain advantages. It tends to outperform the best method studied before when the variation of the data is mainly from the random subject effect instead of error. Furthermore, it allows for greater flexibility in application by enabling incorporation of missing data, confounding covariates, and replications, which was not considered previously. The superiority of this new approach is demonstrated using simulation as well as real-life biomarker data sets used in an electroencephalography clinical study. The implementation of the Bayesian method is accessible through the Comprehensive R Archive Network. PMID:26033433

  12. TVD differencing on three-dimensional unstructured meshes with monotonicity-preserving correction of mesh skewness

    NASA Astrophysics Data System (ADS)

    Denner, Fabian; van Wachem, Berend G. M.

    2015-10-01

    Total variation diminishing (TVD) schemes are a widely applied group of monotonicity-preserving advection differencing schemes for partial differential equations in numerical heat transfer and computational fluid dynamics. These schemes are typically designed for one-dimensional problems or multidimensional problems on structured equidistant quadrilateral meshes. Practical applications, however, often involve complex geometries that cannot be represented by Cartesian meshes and, therefore, necessitate the application of unstructured meshes, which require a more sophisticated discretisation to account for their additional topological complexity. In principle, TVD schemes are applicable to unstructured meshes, however, not all the data required for TVD differencing is readily available on unstructured meshes, and the solution suffers from considerable numerical diffusion as a result of mesh skewness. In this article we analyse TVD differencing on unstructured three-dimensional meshes, focusing on the non-linearity of TVD differencing and the extrapolation of the virtual upwind node. Furthermore, we propose a novel monotonicity-preserving correction method for TVD schemes that significantly reduces numerical diffusion caused by mesh skewness. The presented numerical experiments demonstrate the importance of accounting for the non-linearity introduced by TVD differencing and of imposing carefully chosen limits on the extrapolated virtual upwind node, as well as the efficacy of the proposed method to correct mesh skewness.

  13. Squaring the Circle: Geometric Skewness and Symmetry Breaking for Passive Scalar Transport in Ducts and Pipes.

    PubMed

    Aminian, Manuchehr; Bernardi, Francesca; Camassa, Roberto; McLaughlin, Richard M

    2015-10-01

    We study the role geometry plays in the emergence of asymmetries in diffusing passive scalars advected by pressure-driven flows in ducts and pipes of different aspect ratios. We uncover nonintuitive, multi-time-scale behavior gauged by a new statistic, which we term "geometric skewness" S^{G}, which measures instantaneously forming asymmetries at short times due to flow geometry. This signature distinguishes elliptical pipes of any aspect ratio, for which S^{G}=0, from rectangular ducts whose S^{G} is generically nonzero, and, interestingly, shows that a special duct of aspect ratio ≈0.53335 behaves like a circular pipe as its geometric skewness vanishes. Using a combination of exact solutions, novel short-time asymptotics, and Monte Carlo simulations, we establish the relevant time scales for plateaus and extrema in the evolution of the skewness and kurtosis for our class of geometries. For ducts limiting to channel geometries, we present new exact, single-series formulas for the first four moments on slices used to benchmark Monte Carlo simulations. PMID:26550727

  14. Free vibration of composite skewed cylindrical shell panel by finite element method

    NASA Astrophysics Data System (ADS)

    Haldar, Salil

    2008-03-01

    In this paper a composite triangular shallow shell element has been used for free vibration analysis of laminated composite skewed cylindrical shell panels. In the present element first-order shear deformation theory has been incorporated by taking transverse displacement and bending rotations as independent field variables. The interpolation function used to approximate transverse displacement is one order higher than for bending rotations. This has made the element free from locking in shear. Two types of mass lumping schemes have been recommended. In one of the mass lumping scheme the effect of rotary inertia has been incorporated in the element formulations. Free vibration of skewed composite cylindrical shell panels having different thickness to radius ratios ( h/R=0.01-0.2), length to radius ratios ( L/R), number of layers and fiber orientation angles have been analyzed following the shallow shell method. The results for few examples obtained in the present analysis have compared with the published results. Some new results of composite skewed cylindrical shell panels have been presented which are expected to be useful to future research in this direction.

  15. Coil Creep and Skew-Quadrupole Field Components in the Tevatron

    SciTech Connect

    Annala, G.; Harding, D.J.; Syphers, M.J.; /Fermilab

    2011-07-11

    During the start-up of Run II of the Tevatron Collider program, several issues surfaced which were not present, or not seen as detrimental, during Run I. These included the repeated deterioration of the closed orbit requiring orbit smoothing every two weeks or so, the inability to correct the closed orbit to desired positions due to various correctors running at maximum limits, regions of systematically strong vertical dipole corrections, and the identification of very strong coupling between the two transverse degrees-of-freedom. It became apparent that many of the problems being experienced operationally were connected to a deterioration of the main dipole magnet alignment, and remedial actions were undertaken. However, the alignment alone was not enough to explain the corrector strengths required to handle transverse coupling. With one exception, strong coupling had generally not been an issue in the Tevatron during Run I. Based on experience with the Main Ring, the Tevatron was designed with a very strong skew quadrupole circuit to compensate any quadrupole alignment and skew quadrupole field errors that might present themselves. The circuit was composed of 48 correctors placed evenly throughout the arcs, 8 per sector, evenly placed in every other cell. Other smaller circuits were installed but not initially needed or commissioned. These smaller circuits were composed of individual skew quadrupole correctors on either side of the long straight sections. These circuits were tuned by first bringing the horizontal and vertical tunes near each other. The skew quadrupoles were then adjusted to minimize tune split, usually to less than 0.003. Initially, the main skew quad circuit (designated T:SQ) could accomplish this global decoupling with only 4% of its possible current, and the smaller circuits were not required at all. The start-up of Run Ib was complicated by what was later discovered to be a rolled triplet quadrupole magnet in one of the Interaction Regions

  16. The role of the SST-thermocline relationship in Indian Ocean Dipole skewness and its response to global warming.

    PubMed

    Ng, Benjamin; Cai, Wenju; Walsh, Kevin

    2014-08-12

    A positive Indian Ocean Dipole (IOD) tends to have stronger cold sea surface temperature anomalies (SSTAs) over the eastern Indian Ocean with greater impacts than warm SSTAs that occur during its negative phase. Two feedbacks have been suggested as the cause of positive IOD skewness, a positive Bjerknes feedback and a negative SST-cloud-radiation (SCR) feedback, but their relative importance is debated. Using inter-model statistics, we show that the most important process for IOD skewness is an asymmetry in the thermocline feedback, whereby SSTAs respond to thermocline depth anomalies more strongly during the positive phase than negative phase. This asymmetric thermocline feedback drives IOD skewness despite positive IODs receiving greater damping from the SCR feedback. In response to global warming, although the thermocline feedback strengthens, its asymmetry between positive and negative IODs weakens. This behaviour change explains the reduction in IOD skewness that many models display under global warming.

  17. Using skew-logistic probability density function as a model for age-specific fertility rate pattern.

    PubMed

    Asili, Sahar; Rezaei, Sadegh; Najjar, Lotfollah

    2014-01-01

    Fertility rate is one of the most important global indexes. Past researchers found models which fit to age-specific fertility rates. For example, mixture probability density functions have been proposed for situations with bi-modal fertility patterns. This model is less useful for unimodal age-specific fertility rate patterns, so a model based on skew-symmetric (skew-normal) pdf was proposed by Mazzuco and Scarpa (2011) which was flexible for unimodal and bimodal fertility patterns. In this paper, we introduce skew-logistic probability density function as a better model: its residuals are less than those of the skew-normal model and it can more precisely estimate the parameters of the model. PMID:24967404

  18. Detection of skewed X-chromosome inactivation in Fragile X syndrome and X chromosome aneuploidy using quantitative melt analysis.

    PubMed

    Godler, David E; Inaba, Yoshimi; Schwartz, Charles E; Bui, Quang M; Shi, Elva Z; Li, Xin; Herlihy, Amy S; Skinner, Cindy; Hagerman, Randi J; Francis, David; Amor, David J; Metcalfe, Sylvia A; Hopper, John L; Slater, Howard R

    2015-01-01

    Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGG > 200) females. XCI skewing has been also linked to abnormal X-linked gene expression with the broader clinical impact for sex chromosome aneuploidies (SCAs). In this study, 10 FREE2 CpG sites were targeted using methylation specific quantitative melt analysis (MS-QMA), including 3 sites that could not be analysed with previously used EpiTYPER system. The method was applied for detection of skewed XCI in FM females and in different types of SCA. We tested venous blood and saliva DNA collected from 107 controls (CGG < 40), and 148 FM and 90 SCA individuals. MS-QMA identified: (i) most SCAs if combined with a Y chromosome test; (ii) locus-specific XCI skewing towards the hypomethylated state in FM females; and (iii) skewed XCI towards the hypermethylated state in SCA with 3 or more X chromosomes, and in 5% of the 47,XXY individuals. MS-QMA output also showed significant correlation with the EpiTYPER reference method in FM males and females (P < 0.0001) and SCAs (P < 0.05). In conclusion, we demonstrate use of MS-QMA to quantify skewed XCI in two applications with diagnostic utility. PMID:26132880

  19. Detection of skewed X-chromosome inactivation in Fragile X syndrome and X chromosome aneuploidy using quantitative melt analysis.

    PubMed

    Godler, David E; Inaba, Yoshimi; Schwartz, Charles E; Bui, Quang M; Shi, Elva Z; Li, Xin; Herlihy, Amy S; Skinner, Cindy; Hagerman, Randi J; Francis, David; Amor, David J; Metcalfe, Sylvia A; Hopper, John L; Slater, Howard R

    2015-07-01

    Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGG > 200) females. XCI skewing has been also linked to abnormal X-linked gene expression with the broader clinical impact for sex chromosome aneuploidies (SCAs). In this study, 10 FREE2 CpG sites were targeted using methylation specific quantitative melt analysis (MS-QMA), including 3 sites that could not be analysed with previously used EpiTYPER system. The method was applied for detection of skewed XCI in FM females and in different types of SCA. We tested venous blood and saliva DNA collected from 107 controls (CGG < 40), and 148 FM and 90 SCA individuals. MS-QMA identified: (i) most SCAs if combined with a Y chromosome test; (ii) locus-specific XCI skewing towards the hypomethylated state in FM females; and (iii) skewed XCI towards the hypermethylated state in SCA with 3 or more X chromosomes, and in 5% of the 47,XXY individuals. MS-QMA output also showed significant correlation with the EpiTYPER reference method in FM males and females (P < 0.0001) and SCAs (P < 0.05). In conclusion, we demonstrate use of MS-QMA to quantify skewed XCI in two applications with diagnostic utility.

  20. Numerical investigations of the spreading-rate dependence of anomalous skewness of marine magnetic anomalies due to seafloor spreading

    NASA Astrophysics Data System (ADS)

    Boswell, S. M.; Zheng, L.; Gordon, R. G.; Dyment, J.

    2011-12-01

    An improved understanding of the spreading-rate dependence of anomalous skewness from magnetic anomalies due to seafloor spreading will allow for better constraints on apparent polar wander paths, plate reconstructions, and the magnetic and thermal structure of oceanic lithosphere. Anomalous skewness, which is the difference between experimentally determined skewness and skewness expected from simple magnetization models with vertical reversal boundaries, has been observed to vary as a function of spreading rate, decreasing with increasing spreading rate and becoming negligible at spreading half-rates exceeding about 55 mm/a [Roest et al. 1992; Dyment et al. 1994]. In our analysis, we determine model-based estimates of anomalous skewness as a function of spreading rate for each anomaly. We do so by creating many synthetic profiles using the model of Dyment and Arkani-Hamed (1995), which was specifically constructed to produce anomalies with anomalous skewness consistent with observed anomalies. We experimentally determine the phase shift that causes the resulting synthetic magnetic anomaly to best match a profile produced from a "standard" model for anomalies due to seafloor spreading that assumes simple vertical reversal boundaries. We present results for those anomalies between 12r and 33r from which reliable paleomagnetic poles may potentially be determined. Differences in anomalous skewness for different anomalies determined at the same spreading rate can be attributed to the sequence effect, that is, the effect on the shape of a magnetic anomaly above seafloor of a single polarity chron of the magnetization of neighboring blocks of lithosphere magnetized during other chrons. We find that the sequence effect is smaller than we expected with the largest difference being between the results for anomaly 25r and those for anomaly 33r, for which the difference is 14 degrees at a 10 mm/a half-rate. Results for other anomalies lie between these two. We also infer a

  1. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Astrophysics Data System (ADS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass, heat transfer model with both radially inward and outward flow. Trip strips, skewed at 45 deg to the flow direction, were machined on the leading and trailing surfaces of the radial coolant passages. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. The first three of these four parameters were varied over ranges which are typical of advanced gas turbine engine operating conditions. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. The heat transfer coefficients on surfaces, where the heat transfer decreased with rotation and buoyancy, decreased to as low as 40 percent of the value without rotation. However, the maximum values of the heat transfer coefficients with high rotation were only slightly above the highest levels previously obtained with the smooth wall models. It was concluded that (1) both Coriolis and buoyancy effects must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer in models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design information.

  2. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1992-01-01

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass, heat transfer model with both radially inward and outward flow. Trip strips, skewed at 45 deg to the flow direction, were machined on the leading and trailing surfaces of the radial coolant passages. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. The first three of these four parameters were varied over ranges which are typical of advanced gas turbine engine operating conditions. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. The heat transfer coefficients on surfaces, where the heat transfer decreased with rotation and buoyancy, decreased to as low as 40 percent of the value without rotation. However, the maximum values of the heat transfer coefficients with high rotation were only slightly above the highest levels previously obtained with the smooth wall models. It was concluded that (1) both Coriolis and buoyancy effects must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer in models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design information.

  3. Measuring skew in average surface roughness as a function of surface preparation

    NASA Astrophysics Data System (ADS)

    Stahl, Mark T.

    2015-08-01

    Characterizing surface roughness is important for predicting optical performance. Better measurement of surface roughness reduces polishing time, saves money and allows the science requirements to be better defined. This study characterized statistics of average surface roughness as a function of polishing time. Average surface roughness was measured at 81 locations using a Zygo® white light interferometer at regular intervals during the polishing process. Each data set was fit to a normal and Largest Extreme Value (LEV) distribution; then tested for goodness of fit. We show that the skew in the average data changes as a function of polishing time.

  4. Eigenvalue analysis of an irreversible random walk with skew detailed balance conditions.

    PubMed

    Sakai, Yuji; Hukushima, Koji

    2016-04-01

    An irreversible Markov-chain Monte Carlo (MCMC) algorithm with skew detailed balance conditions originally proposed by Turitsyn et al. is extended to general discrete systems on the basis of the Metropolis-Hastings scheme. To evaluate the efficiency of our proposed method, the relaxation dynamics of the slowest mode and the asymptotic variance are studied analytically in a random walk on one dimension. It is found that the performance in irreversible MCMC methods violating the detailed balance condition is improved by appropriately choosing parameters in the algorithm. PMID:27176439

  5. A method for skew-free distribution of digital signals using matched variable delay lines

    NASA Astrophysics Data System (ADS)

    Knight, Thomas; Wu, Henry

    1992-03-01

    The ability to distribute signals to all parts of a circuit with precisely controlled and known delays is essential in large, high-speed digital systems. We present a technique by which a signal driver can adjust the arrival time of the signal at the end of the wire using a pair of matched variable delay lines. We show how this idea can be implemented requiring no extra wiring, and how it can be extended to distribute signals skew-free to receivers along the signal run as well as the receiving end. We demonstrate how this scheme can be implemented as part of the pad and scan logic of a VLSI chip.

  6. Asymptotic of the Solutions of Hyperbolic Equations with a Skew-Symmetric Perturbation

    NASA Astrophysics Data System (ADS)

    Gallagher, Isabelle

    1998-12-01

    Using methods introduced by S. Schochet inJ. Differential Equations114(1994), 476-512, we compute the first term of an asymptotic expansion of the solutions of hyperbolic equations perturbated by a skew-symmetric linear operator. That result is first applied to two systems describing the motion of geophysic fluids: the rotating Euler equations and the primitive system of the quasigeostrophic equations. Finally in the last part, we study the slightly compressible Euler equations by application of that same result.

  7. Stability of a cantilevered skew inhomogeneous plate in supersonic gas flow

    NASA Astrophysics Data System (ADS)

    Isaulova, T. N.; Lavit, I. M.

    2011-07-01

    This paper considers the vibrations of a skew inhomogeneous plate in gas flow. The plate is clamped in a certain section of one of its sides. Interaction of the flow with the plate is described using piston theory. The problem solution is based on the Hamilton's variational principle and finite element method. The calculation results are compared with known data of theoretical studies and experiments. For the inhomogeneous plate, similarity parameters were established for the problem, which, in practically important cases, appears to be self-similar for one of the similarity parameters. This allows one to reduce the solution of this problem to the solution of an algebraic eigenvalue problem.

  8. Extrinsic spin Hall effect induced by resonant skew scattering in graphene.

    PubMed

    Ferreira, Aires; Rappoport, Tatiana G; Cazalilla, Miguel A; Castro Neto, A H

    2014-02-14

    We show that the extrinsic spin Hall effect can be engineered in monolayer graphene by decoration with small doses of adatoms, molecules, or nanoparticles originating local spin-orbit perturbations. The analysis of the single impurity scattering problem shows that intrinsic and Rashba spin-orbit local couplings enhance the spin Hall effect via skew scattering of charge carriers in the resonant regime. The solution of the transport equations for a random ensemble of spin-orbit impurities reveals that giant spin Hall currents are within the reach of the current state of the art in device fabrication. The spin Hall effect is robust with respect to thermal fluctuations and disorder averaging.

  9. Extrinsic Spin Hall Effect Induced by Resonant Skew Scattering in Graphene

    NASA Astrophysics Data System (ADS)

    Ferreira, Aires; Rappoport, Tatiana G.; Cazalilla, Miguel A.; Castro Neto, A. H.

    2014-02-01

    We show that the extrinsic spin Hall effect can be engineered in monolayer graphene by decoration with small doses of adatoms, molecules, or nanoparticles originating local spin-orbit perturbations. The analysis of the single impurity scattering problem shows that intrinsic and Rashba spin-orbit local couplings enhance the spin Hall effect via skew scattering of charge carriers in the resonant regime. The solution of the transport equations for a random ensemble of spin-orbit impurities reveals that giant spin Hall currents are within the reach of the current state of the art in device fabrication. The spin Hall effect is robust with respect to thermal fluctuations and disorder averaging.

  10. Measuring Skew in Average Surface Roughness as a Function of Surface Preparation

    NASA Technical Reports Server (NTRS)

    Stahl, Mark

    2015-01-01

    Characterizing surface roughness is important for predicting optical performance. Better measurement of surface roughness reduces polishing time, saves money and allows the science requirements to be better defined. This study characterized statistics of average surface roughness as a function of polishing time. Average surface roughness was measured at 81 locations using a Zygo white light interferometer at regular intervals during the polishing process. Each data set was fit to a normal and Largest Extreme Value (LEV) distribution; then tested for goodness of fit. We show that the skew in the average data changes as a function of polishing time.

  11. Measuring Skew in Average Surface Roughness as a Function of Surface Preparation

    NASA Technical Reports Server (NTRS)

    Stahl, Mark T.

    2015-01-01

    Characterizing surface roughness is important for predicting optical performance. Better measurement of surface roughness reduces grinding saving both time and money and allows the science requirements to be better defined. In this study various materials are polished from a fine grind to a fine polish. Each sample's RMS surface roughness is measured at 81 locations in a 9x9 square grid using a Zygo white light interferometer at regular intervals during the polishing process. Each data set is fit with various standard distributions and tested for goodness of fit. We show that the skew in the RMS data changes as a function of polishing time.

  12. A variational Bayesian approach for inverse problems with skew-t error distributions

    NASA Astrophysics Data System (ADS)

    Guha, Nilabja; Wu, Xiaoqing; Efendiev, Yalchin; Jin, Bangti; Mallick, Bani K.

    2015-11-01

    In this work, we develop a novel robust Bayesian approach to inverse problems with data errors following a skew-t distribution. A hierarchical Bayesian model is developed in the inverse problem setup. The Bayesian approach contains a natural mechanism for regularization in the form of a prior distribution, and a LASSO type prior distribution is used to strongly induce sparseness. We propose a variational type algorithm by minimizing the Kullback-Leibler divergence between the true posterior distribution and a separable approximation. The proposed method is illustrated on several two-dimensional linear and nonlinear inverse problems, e.g. Cauchy problem and permeability estimation problem.

  13. Maximum Parsimony and the Skewness Test: A Simulation Study of the Limits of Applicability

    PubMed Central

    Määttä, Jussi; Roos, Teemu

    2016-01-01

    The maximum parsimony (MP) method for inferring phylogenies is widely used, but little is known about its limitations in non-asymptotic situations. This study employs large-scale computations with simulated phylogenetic data to estimate the probability that MP succeeds in finding the true phylogeny for up to twelve taxa and 256 characters. The set of candidate phylogenies are taken to be unrooted binary trees; for each simulated data set, the tree lengths of all (2n − 5)!! candidates are computed to evaluate quantities related to the performance of MP, such as the probability of finding the true phylogeny, the probability that the tree with the shortest length is unique, the probability that the true phylogeny has the shortest tree length, and the expected inverse of the number of trees sharing the shortest length. The tree length distributions are also used to evaluate and extend the skewness test of Hillis for distinguishing between random and phylogenetic data. The results indicate, for example, that the critical point after which MP achieves a success probability of at least 0.9 is roughly around 128 characters. The skewness test is found to perform well on simulated data and the study extends its scope to up to twelve taxa. PMID:27035667

  14. Using Skewness and the First-Digit Phenomenon to Identify Dynamical Transitions in Cardiac Models

    PubMed Central

    Seenivasan, Pavithraa; Easwaran, Soumya; Sridhar, Seshan; Sinha, Sitabhra

    2016-01-01

    Disruptions in the normal rhythmic functioning of the heart, termed as arrhythmia, often result from qualitative changes in the excitation dynamics of the organ. The transitions between different types of arrhythmia are accompanied by alterations in the spatiotemporal pattern of electrical activity that can be measured by observing the time-intervals between successive excitations of different regions of the cardiac tissue. Using biophysically detailed models of cardiac activity we show that the distribution of these time-intervals exhibit a systematic change in their skewness during such dynamical transitions. Further, the leading digits of the normalized intervals appear to fit Benford's law better at these transition points. This raises the possibility of using these observations to design a clinical indicator for identifying changes in the nature of arrhythmia. More importantly, our results reveal an intriguing relation between the changing skewness of a distribution and its agreement with Benford's law, both of which have been independently proposed earlier as indicators of regime shift in dynamical systems. PMID:26793114

  15. Changes of skewness and sharpness of partially coherent decentered annular beams on propagation

    NASA Astrophysics Data System (ADS)

    Yang, Ting; Ji, Xiaoling; Li, Xiaoqing; Zhang, Hao; Wang, Tao

    2016-01-01

    Changes of skewness and sharpness of partially coherent decentered annular beams (PCDA beams) on propagation both in free space and in oceanic turbulence are studied. Based on the Wigner distribution function, the analytical expressions for the skewness parameter A and the kurtosis parameter K of PCDA beams are derived. The analytical expression for the oceanic turbulence parameter T‧ related to K is also derived, and characteristics of T‧ are examined. It is found that the behaviors of A and K in oceanic turbulence are quite different from those in free space. In free space, the mass of the intensity distribution may move from one side of the centroid position axis yc to another side at a certain propagation distance z0, and z0 is independent of the correlation parameter τ. The mass of the intensity distribution is concentrated on one side of yc on propagation only for a poorly coherent beam in free space, but it is always this situation for different value of τ when oceanic turbulence is not weak. In free space, it takes a leptokurtic profile in the far field, and a Gaussian profile appears only for a poorly coherent beam. However, in oceanic turbulence it always reaches a Gaussian profile for different value of τ in the far field.

  16. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Astrophysics Data System (ADS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1992-06-01

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass heat transfer model with both radially inward and outward flow. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. It was concluded that (1) both Coriolis and buoyancy must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design.

  17. Hematopoietic lineage skewing and intestinal epithelia degeneration in aged mice with telomerase RNA component deletion.

    PubMed

    Chen, Jichun; Bryant, Mark A; Dent, James J; Sun, Yu; Desierto, Marie J; Young, Neal S

    2015-12-01

    A deletion of a telomerase RNA component (Terc(-/-)) in C57BL/6 (B6) mice resulted in hematopoietic lineage skewing with increased neutrophils and CD11b(+) myeloid cells and decreased red blood cells and CD45R(+) B lymphocytes when animals reach ages older than 12 months. There was no decline in bone marrow (BM) c-Kit(+)Sca-1(+)Lin(-) (KSL) cells in old Terc(-/-) mice, and the lineage skewing phenomenon was not transferred when BM cells from old Terc(-/-) donors were transplanted into young B6 recipients. Necropsy and histological examinations found minimal to no change in the lung, spleen and liver but detected severe epithelia degeneration, ulceration and infection in small and large intestines, leading to enteritis, typhlitis and colitis in old Terc(-/-) mice. In a mouse model of dextran-sulfate-sodium-induced typhlitis and colitis, development of intestinal pathology was associated with increases in neutrophils and CD11b(+) myeloid cells and a decrease in CD45R(+) B cells, similar to those observed in old Terc(-/-) mice. Treatment of 11-13 month old Terc(-/-) mice with antibiotic trimethoprim-sulfa water reduced neutrophils and myeloid cells and increased B lymphocytes in the blood, indicating that mitigation of intestinal infection and inflammation could alleviate hematological abnormalities in old Terc(-/-) animals. PMID:26523501

  18. Hematopoietic lineage skewing and intestinal epithelia degeneration in aged mice with telomerase RNA component deletion.

    PubMed

    Chen, Jichun; Bryant, Mark A; Dent, James J; Sun, Yu; Desierto, Marie J; Young, Neal S

    2015-12-01

    A deletion of a telomerase RNA component (Terc(-/-)) in C57BL/6 (B6) mice resulted in hematopoietic lineage skewing with increased neutrophils and CD11b(+) myeloid cells and decreased red blood cells and CD45R(+) B lymphocytes when animals reach ages older than 12 months. There was no decline in bone marrow (BM) c-Kit(+)Sca-1(+)Lin(-) (KSL) cells in old Terc(-/-) mice, and the lineage skewing phenomenon was not transferred when BM cells from old Terc(-/-) donors were transplanted into young B6 recipients. Necropsy and histological examinations found minimal to no change in the lung, spleen and liver but detected severe epithelia degeneration, ulceration and infection in small and large intestines, leading to enteritis, typhlitis and colitis in old Terc(-/-) mice. In a mouse model of dextran-sulfate-sodium-induced typhlitis and colitis, development of intestinal pathology was associated with increases in neutrophils and CD11b(+) myeloid cells and a decrease in CD45R(+) B cells, similar to those observed in old Terc(-/-) mice. Treatment of 11-13 month old Terc(-/-) mice with antibiotic trimethoprim-sulfa water reduced neutrophils and myeloid cells and increased B lymphocytes in the blood, indicating that mitigation of intestinal infection and inflammation could alleviate hematological abnormalities in old Terc(-/-) animals.

  19. Analyzing Fish Condition Factor Index Through Skew-Gaussian Information Theory Quantifiers

    NASA Astrophysics Data System (ADS)

    Contreras-Reyes, Javier E.

    2016-06-01

    Biological-fishery indicators have been widely studied. As such the condition factor (CF) index, which interprets the fatness level of a certain species based on length and weight, has been investigated, too. However, CF has been studied without considering its temporal features and distribution. In this paper, we analyze the CF time series via skew-gaussian distributions that consider the asymmetry produced by extreme events. This index is characterized by a threshold autoregressive model and corresponds to a stationary process depending on the shape parameter of the skew-gaussian distribution. Then we use the Jensen-Shannon (JS) distance to compare CF by length classes. This distance has mathematical advantages over other divergences such as Kullback-Leibler and Jeffrey’s, and the triangular inequality property. Our results are applied to a biological catalogue of anchovy (Engraulis ringens) from the northern coast of Chile, for the period 1990-2010 that consider monthly CF time series by length classes and sex. We find that for high values of shape parameter, JS distance tends to be more sensible to detect discrepancies than Jeffrey’s divergence. In addition, the body condition of male anchovies with higher lengths coincides with the ending of the moderate-strong El Niño event 91-92 and for both males and females, the smaller lengths coincide with the beginning of the strong El Niño event 97-98.

  20. Skewness and kurtosis as indicators of non-Gaussianity in galactic foreground maps

    SciTech Connect

    Ben-David, Assaf; Jackson, Andrew D.; Hausegger, Sebastian von E-mail: s.vonhausegger@nbi.dk

    2015-11-01

    Observational cosmology is entering an era in which high precision will be required in both measurement and data analysis. Accuracy, however, can only be achieved with a thorough understanding of potential sources of contamination from foreground effects. Our primary focus will be on non-Gaussian effects in foregrounds. This issue will be crucial for coming experiments to determine B-mode polarization. We propose a novel method for investigating a data set in terms of skewness and kurtosis in locally defined regions that collectively cover the entire sky. The method is demonstrated on two sky maps: (i) the SMICA map of Cosmic Microwave Background fluctuations provided by the Planck Collaboration and (ii) a version of the Haslam map at 408 MHz that describes synchrotron radiation. We find that skewness and kurtosis can be evaluated in combination to reveal local physical information. In the present case, we demonstrate that the statistical properties of both maps in small local regions are predominantly Gaussian. This result was expected for the SMICA map. It is surprising that it also applies for the Haslam map given its evident large scale non-Gaussianity. The approach described here has a generality and flexibility that should make it useful in a variety of astrophysical and cosmological contexts.

  1. Near and Far Field Acoustic Pressure Skewness in a Heated Supersonic Jet

    NASA Astrophysics Data System (ADS)

    Gutmark, Ephraim; Mora, Pablo; Kastner, Jeff; Heeb, Nick; Kailasanath, Kailas; Liu, Junhui; University of Cincinnati Collaboration; Naval Research Laboratory Collaboration

    2012-11-01

    The dominant component of turbulent mixing noise in high speed jets is the Mach wave radiation generated by large turbulent structures in the shear layer The Over-All Sound Pressure Level (OASPL) in the far field peaks in a direction near the Mach wave angle. ``Crackle'' is another important component of high speed jet noise. Crackle cannot be recognized in the spectrum of the acoustic pressure signal, but it appears in the temporal waveform of the pressure as sharply rising peaks. Skewness levels of the pressure and dP/dt have been used as a measure of crackle in high specific thrust engines and rockets. In this paper, we focus on recognizing a technique that identifies the impact of different test conditions on the near-field and far-field statistics of the pressure and dP/dt signals of a supersonic jet with a design Mach number of Md=1.5 produced by a C-D conical nozzle. Cold and hot jets, T0=300K and 600K, are tested at over, design, and under-expanded conditions, with NPRs=2.5, 3.671, 4.5, respectively. Second, Third and Forth order statistics are examined in the near and far fields. Rms, skewness and kurtosis intensity levels and propagation are better identified in the dP/dt than in the pressure signal. Statistics of the dP/dt demonstrate to be a better measure for crackle. Project funded by ONR grant.

  2. Homoclinic snaking in plane Couette flow: bending, skewing and finite-size effects

    NASA Astrophysics Data System (ADS)

    Gibson, J. F.; Schneider, T. M.

    2016-05-01

    Invariant solutions of shear flows have recently been extended from spatially periodic solutions in minimal flow units to spatially localized solutions on extended domains. One set of spanwise-localized solutions of plane Couette flow exhibits homoclinic snaking, a process by which steady-state solutions grow additional structure smoothly at their fronts when continued parametrically. Homoclinic snaking is well understood mathematically in the context of the one-dimensional Swift-Hohenberg equation. Consequently, the snaking solutions of plane Couette flow form a promising connection between the largely phenomenological study of laminar-turbulent patterns in viscous shear flows and the mathematically well-developed field of pattern-formation theory. In this paper we present a numerical study of the snaking solutions, generalizing beyond the fixed streamwise wavelength of previous studies. We find a number of new solution features, including bending, skewing, and finite-size effects. We show that the finite-size effects result from the shift-reflect symmetry of the traveling wave and establish the parameter regions over which snaking occurs. A new winding solution of plane Couette flow is derived from a strongly skewed localized equilibrium.

  3. Langevin equation modeling of convective boundary layer dispersion assuming homogeneous, skewed turbulence

    SciTech Connect

    Hasstrom, J.S.; Ermak, D.L.

    1997-10-01

    Vertical dispersion of material in the convective boundary layer, CBL, is dramatically different than in natural or stable boundary layers, as has been shown by field and laboratory experiments. Lagrangian stochastic modeling based on the Langevin equation has been shown to be useful for simulating vertical dispersion in the CBL. This modeling approach can account for the effects of the long Lagrangian time scales (associated with large-scale turbulent structures), skewed vertical velocity distributions, and vertically inhomogeneous turbulent properties found in the CBL. It has been recognized that simplified Langevin equation models that assume skewed but homogeneous velocity statistics can capture the important aspects of dispersion from sources the the CBL. The assumption of homogeneous turbulence has a significant practical advantage, specifically, longer time steps can be used in numerical simulations. In this paper, we compare two Langevin equations models that use the homogeneous turbulence assumption. We also compare and evaluate three reflection boundary conditions, the method for determining a new velocity for a particle that encounters a boundary. Model results are evaluated using data from Willis and Deardorff`s laboratory experiments for three different source heights.

  4. Understanding the distinctively skewed and heavy tailed character of atmospheric and oceanic probability distributions

    SciTech Connect

    Sardeshmukh, Prashant D.

    2015-03-15

    The probability distributions of large-scale atmospheric and oceanic variables are generally skewed and heavy-tailed. We argue that their distinctive departures from Gaussianity arise fundamentally from the fact that in a quadratically nonlinear system with a quadratic invariant, the coupling coefficients between system components are not constant but depend linearly on the system state in a distinctive way. In particular, the skewness arises from a tendency of the system trajectory to linger near states of weak coupling. We show that the salient features of the observed non-Gaussianity can be captured in the simplest such nonlinear 2-component system. If the system is stochastically forced and linearly damped, with one component damped much more strongly than the other, then the strongly damped fast component becomes effectively decoupled from the weakly damped slow component, and its impact on the slow component can be approximated as a stochastic noise forcing plus an augmented nonlinear damping. In the limit of large time-scale separation, the nonlinear augmentation of the damping becomes small, and the noise forcing can be approximated as an additive noise plus a correlated additive and multiplicative noise (CAM noise) forcing. Much of the diversity of observed large-scale atmospheric and oceanic probability distributions can be interpreted in this minimal framework.

  5. Comment on "Universal relation between skewness and kurtosis in complex dynamics"

    NASA Astrophysics Data System (ADS)

    Celikoglu, Ahmet; Tirnakli, Ugur

    2015-12-01

    In a recent paper [M. Cristelli, A. Zaccaria, and L. Pietronero, Phys. Rev. E 85, 066108 (2012), 10.1103/PhysRevE.85.066108], the authors analyzed the relation between skewness and kurtosis for complex dynamical systems, and they identified two power-law regimes of non-Gaussianity, one of which scales with an exponent of 2 and the other with 4 /3 . They concluded that the observed relation is a universal fact in complex dynamical systems. In this Comment, we test the proposed universal relation between skewness and kurtosis with a large number of synthetic data, and we show that in fact it is not a universal relation and originates only due to the small number of data points in the datasets considered. The proposed relation is tested using a family of non-Gaussian distribution known as q -Gaussians. We show that this relation disappears for sufficiently large datasets provided that the fourth moment of the distribution is finite. We find that kurtosis saturates to a single value, which is of course different from the Gaussian case (K =3 ), as the number of data is increased, and this indicates that the kurtosis will converge to a finite single value if all moments of the distribution up to fourth are finite. The converged kurtosis value for the finite fourth-moment distributions and the number of data points needed to reach this value depend on the deviation of the original distribution from the Gaussian case.

  6. Random sampling of skewed distributions implies Taylor's power law of fluctuation scaling.

    PubMed

    Cohen, Joel E; Xu, Meng

    2015-06-23

    Taylor's law (TL), a widely verified quantitative pattern in ecology and other sciences, describes the variance in a species' population density (or other nonnegative quantity) as a power-law function of the mean density (or other nonnegative quantity): Approximately, variance = a(mean)(b), a > 0. Multiple mechanisms have been proposed to explain and interpret TL. Here, we show analytically that observations randomly sampled in blocks from any skewed frequency distribution with four finite moments give rise to TL. We do not claim this is the only way TL arises. We give approximate formulae for the TL parameters and their uncertainty. In computer simulations and an empirical example using basal area densities of red oak trees from Black Rock Forest, our formulae agree with the estimates obtained by least-squares regression. Our results show that the correlated sampling variation of the mean and variance of skewed distributions is statistically sufficient to explain TL under random sampling, without the intervention of any biological or behavioral mechanisms. This finding connects TL with the underlying distribution of population density (or other nonnegative quantity) and provides a baseline against which more complex mechanisms of TL can be compared. PMID:25852144

  7. Diffuse holographic interferometric observation of shock wave reflection from a skewed wedge

    NASA Astrophysics Data System (ADS)

    Numata, D.; Ohtani, K.; Takayama, K.

    2009-06-01

    The pattern of shock wave reflection over a wedge is, in general, either a regular reflection or a Mach reflection, depending on wedge angles, shock wave Mach numbers, and specific heat ratios of gases. However, regular and Mach reflections can coexist, in particular, over a three-dimensional wedge surface, whose inclination angles locally vary normal to the direction of shock propagation. This paper reports a result of diffuse double exposure holographic interferometric observations of shock wave reflections over a skewed wedge surface placed in a 100 × 180 mm shock tube. The wedge consists of a straight generating line whose local inclination angle varies continuously from 30° to 60°. Painting its surface with fluorescent spray paint and irradiating its surface with a collimated object beam at a time interval of a few microseconds, we succeeded in visualizing three-dimensional shock reflection over the skewed wedge surface. Experiments were performed at shock Mach numbers, 1.55, 2.02, and 2.53 in air. From reconstructed holographic images, we estimated critical transition angles at these shock wave Mach numbers and found that these were very close to those over straight wedges. This is attributable to the flow three-dimensionality.

  8. Fuel cell plates with skewed process channels for uniform distribution of stack compression load

    DOEpatents

    Granata, Jr., Samuel J.; Woodle, Boyd M.

    1989-01-01

    An electrochemical fuel cell includes an anode electrode, a cathode electrode, an electrolyte matrix sandwiched between electrodes, and a pair of plates above and below the electrodes. The plate above the electrodes has a lower surface with a first group of process gas flow channels formed thereon and the plate below the electrodes has an upper surface with a second group of process gas flow channels formed thereon. The channels of each group extend generally parallel to one another. The improvement comprises the process gas flow channels on the lower surface of the plate above the anode electrode and the process gas flow channels on the upper surface of the plate below the cathode electrode being skewed in opposite directions such that contact areas of the surfaces of the plates through the electrodes are formed in crisscross arrangements. Also, the plates have at least one groove in areas of the surfaces thereof where the channels are absent for holding process gas and increasing electrochemical activity of the fuel cell. The groove in each plate surface intersects with the process channels therein. Also, the opposite surfaces of a bipolar plate for a fuel cell contain first and second arrangements of process gas flow channels in the respective surfaces which are skewed the same amount in opposite directions relative to the longitudinal centerline of the plate.

  9. Deconstructing risk: Separable encoding of variance and skewness in the brain

    PubMed Central

    Symmonds, Mkael; Wright, Nicholas D.; Bach, Dominik R.; Dolan, Raymond J.

    2011-01-01

    Risky choice entails a need to appraise all possible outcomes and integrate this information with individual risk preference. Risk is frequently quantified solely by statistical variance of outcomes, but here we provide evidence that individuals’ choice behaviour is sensitive to both dispersion (variance) and asymmetry (skewness) of outcomes. Using a novel behavioural paradigm in humans, we independently manipulated these ‘summary statistics’ while scanning subjects with fMRI. We show that a behavioural sensitivity to variance and skewness is mirrored in neuroanatomically dissociable representations of these quantities, with parietal cortex showing sensitivity to the former and prefrontal cortex and ventral striatum to the latter. Furthermore, integration of these objective risk metrics with subjective risk preference is expressed in a subject-specific coupling between neural activity and choice behaviour in anterior insula. Our findings show that risk is neither monolithic from a behavioural nor neural perspective and its decomposition is evident both in distinct behavioural preferences and in segregated underlying brain representations. PMID:21763444

  10. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1992-01-01

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass heat transfer model with both radially inward and outward flow. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. It was concluded that (1) both Coriolis and buoyancy must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design.

  11. Maximum Parsimony and the Skewness Test: A Simulation Study of the Limits of Applicability.

    PubMed

    Määttä, Jussi; Roos, Teemu

    2016-01-01

    The maximum parsimony (MP) method for inferring phylogenies is widely used, but little is known about its limitations in non-asymptotic situations. This study employs large-scale computations with simulated phylogenetic data to estimate the probability that MP succeeds in finding the true phylogeny for up to twelve taxa and 256 characters. The set of candidate phylogenies are taken to be unrooted binary trees; for each simulated data set, the tree lengths of all (2n - 5)!! candidates are computed to evaluate quantities related to the performance of MP, such as the probability of finding the true phylogeny, the probability that the tree with the shortest length is unique, the probability that the true phylogeny has the shortest tree length, and the expected inverse of the number of trees sharing the shortest length. The tree length distributions are also used to evaluate and extend the skewness test of Hillis for distinguishing between random and phylogenetic data. The results indicate, for example, that the critical point after which MP achieves a success probability of at least 0.9 is roughly around 128 characters. The skewness test is found to perform well on simulated data and the study extends its scope to up to twelve taxa. PMID:27035667

  12. Patterns of paternity skew among polyandrous social insects: what can they tell us about the potential for sexual selection?

    PubMed

    Jaffé, Rodolfo; Garcia-Gonzalez, Francisco; den Boer, Susanne P A; Simmons, Leigh W; Baer, Boris

    2012-12-01

    Monogamy results in high genetic relatedness among offspring and thus it is generally assumed to be favored by kin selection. Female multiple mating (polyandry) has nevertheless evolved several times in the social Hymenoptera (ants, bees, and wasps), and a substantial amount of work has been conducted to understand its costs and benefits. Relatedness and inclusive fitness benefits are, however, not only influenced by queen mating frequency but also by paternity skew, which is a quantitative measure of paternity biases among the offspring of polyandrous females. We performed a large-scale phylogenetic analysis of paternity skew across polyandrous social Hymenoptera. We found a general and significant negative association between paternity frequency and paternity skew. High paternity skew, which increases relatedness among colony members and thus maximizes inclusive fitness gains, characterized species with low paternity frequency. However, species with highly polyandrous queens had low paternity skew, with paternity equalized among potential sires. Equal paternity shares among fathers are expected to maximize fitness benefits derived from genetic diversity among offspring. We discuss the potential for postcopulatory sexual selection to influence patterns of paternity in social insects, and suggest that sexual selection may have played a key, yet overlooked role in social evolution.

  13. Modeling Landscape-Level Spatial Variation in Sex Ratio Skew in the Mountain Pine Beetle (Coleoptera: Curculionidae).

    PubMed

    James, Patrick M A; Janes, Jasmine K; Roe, Amanda D; Cooke, Barry J

    2016-08-01

    Through their influence on effective population sizes, sex ratio skew affects population dynamics. We examined spatial variation in female-biased sex ratios in the mountain pine beetle (Dendroctonus ponderosae Hopkins) outbreak in western Canada to better understand how environmental context affects sex ratio skew. Our specific objectives were to: 1) characterize spatial variation in mountain pine beetle sex ratio; 2) test previously asserted hypotheses that beetle sex ratio varies with tree diameter and year in outbreak; and 3) develop predictive models of sex ratio skew for larval and adult populations. Using logistic regression, we modeled the probability that an individual beetle (n = 2,369) was female as a function of multiple environmental variables across 34 stands in British Columbia and Alberta, Canada. We identified a consistent female-biased sex ratio with significantly greater skew in adults (2:1, n = 713) than in larvae (1.76:1, n = 1,643). We found that the proportion of larval females increased with decreasing tree size and with outbreak age. However, adults did not respond to tree size and larvae did not respond to outbreak age. Predictive models differed between larvae and adults. All identified models perform well and included predictors related to weather, tree diameter, and year in outbreak. Female-biased sex ratios appear to originate from differential male mortality during development rather than from sex-biased oviposition, suggesting sex ratio skew is not the cause of outbreaks, but rather a consequence. PMID:27209334

  14. Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females.

    PubMed

    Gentilini, Davide; Garagnani, Paolo; Pisoni, Serena; Bacalini, Maria Giulia; Calzari, Luciano; Mari, Daniela; Vitale, Giovanni; Franceschi, Claudio; Di Blasio, Anna Maria

    2015-08-01

    In this study we applied a new analytical strategy to investigate the relations between stochastic epigenetic mutations (SEMs) and aging. We analysed methylation levels through the Infinium HumanMethylation27 and HumanMethylation450 BeadChips in a population of 178 subjects ranging from 3 to 106 years. For each CpG probe, epimutated subjects were identified as the extreme outliers with methylation level exceeding three times interquartile ranges the first quartile (Q1-(3 x IQR)) or the third quartile (Q3+(3 x IQR)). We demonstrated that the number of SEMs was low in childhood and increased exponentially during aging. Using the HUMARA method, skewing of X chromosome inactivation (XCI) was evaluated in heterozygotes women. Multivariate analysis indicated a significant correlation between log(SEMs) and degree of XCI skewing after adjustment for age (β = 0.41; confidence interval: 0.14, 0.68; p-value = 0.0053). The PATH analysis tested the complete model containing the variables: skewing of XCI, age, log(SEMs) and overall CpG methylation. After adjusting for the number of epimutations we failed to confirm the well reported correlation between skewing of XCI and aging. This evidence might suggest that the known correlation between XCI skewing and aging could not be a direct association but mediated by the number of SEMs.

  15. Modeling Landscape-Level Spatial Variation in Sex Ratio Skew in the Mountain Pine Beetle (Coleoptera: Curculionidae).

    PubMed

    James, Patrick M A; Janes, Jasmine K; Roe, Amanda D; Cooke, Barry J

    2016-08-01

    Through their influence on effective population sizes, sex ratio skew affects population dynamics. We examined spatial variation in female-biased sex ratios in the mountain pine beetle (Dendroctonus ponderosae Hopkins) outbreak in western Canada to better understand how environmental context affects sex ratio skew. Our specific objectives were to: 1) characterize spatial variation in mountain pine beetle sex ratio; 2) test previously asserted hypotheses that beetle sex ratio varies with tree diameter and year in outbreak; and 3) develop predictive models of sex ratio skew for larval and adult populations. Using logistic regression, we modeled the probability that an individual beetle (n = 2,369) was female as a function of multiple environmental variables across 34 stands in British Columbia and Alberta, Canada. We identified a consistent female-biased sex ratio with significantly greater skew in adults (2:1, n = 713) than in larvae (1.76:1, n = 1,643). We found that the proportion of larval females increased with decreasing tree size and with outbreak age. However, adults did not respond to tree size and larvae did not respond to outbreak age. Predictive models differed between larvae and adults. All identified models perform well and included predictors related to weather, tree diameter, and year in outbreak. Female-biased sex ratios appear to originate from differential male mortality during development rather than from sex-biased oviposition, suggesting sex ratio skew is not the cause of outbreaks, but rather a consequence.

  16. Development of a contour map showing generalized skew coefficients of annual peak discharges of rural, unregulated streams in New York, excluding Long Island

    USGS Publications Warehouse

    Lumia, Richard; Baevsky, Yvonne H.

    2000-01-01

    Flood-frequency relations that are developed by fitting the logarithms of annual peak discharges to a Pearson Type-III distribution are sensitive to skew coefficients. Estimates of population skew for a site are improved when computed from the weighted average of (1) the sample (station) skew, and (2) an unbiased, generalized skew estimate. A weighting technique based on the number of years of record at each of 226 sites was used to develop a contour map of unbiased, generalized skew coefficients for New York. An attempt was made to group (regionalize) the station skew coefficients into five hydrologically similar areas of New York, but the statewide version proved to be as accurate as the regionalized version and therefore was adopted as the final generalized skew-coefficient map for New York. An error analysis showed the statewide contour map to have lower MSE?s (mean square errors) than those computed from (1) the five regional skewcoefficient contour maps, (2) a previously used (1982) nationwide skew coefficient map, and (3) the weighted mean of skew coefficients for sites within each of five hydrologically uniform, but distinct areas of New York.

  17. Uniform and strict persistence in monotone skew-product semiflows with applications to non-autonomous Nicholson systems

    NASA Astrophysics Data System (ADS)

    Obaya, Rafael; Sanz, Ana M.

    2016-10-01

    We determine sufficient conditions for uniform and strict persistence in the case of skew-product semiflows generated by solutions of non-autonomous families of cooperative systems of ODEs or delay FDEs in terms of the principal spectrums of some associated linear skew-product semiflows which admit a continuous separation. Our conditions are also necessary in the linear case. We apply our results to a noncooperative almost periodic Nicholson system with a patch structure, whose persistence turns out to be equivalent to the persistence of the linearized system along the null solution.

  18. Random X-chromosome inactivation: skewing lessons for mice and men.

    PubMed

    Clerc, Philippe; Avner, Philip

    2006-06-01

    The mammalian X-chromosome exists in two flavors, active and inactive, in each cell of the adult female. This phenomenon originates from the process of random choice occurring early in development in a small number of progenitor cells in which the decision is made to inactivate either one or the other X chromosome on a cell-autonomous basis. Once made, this initial decision is irreversible, although exceptions exist in specific chromosomal territories and cell lineages. Recent findings implicate various factors, including non-coding RNAs and chromatin modification complexes, as effectors in the initiation and maintenance of X-chromosome inactivation. The functional redundancy of such factors almost certainly plays an important role in the stability of the inactive X. Studying skewing or bias opens an important opportunity for understanding facets of the random choice process.

  19. A Simple Simulation Technique for Nonnormal Data with Prespecified Skewness, Kurtosis, and Covariance Matrix.

    PubMed

    Foldnes, Njål; Olsson, Ulf Henning

    2016-01-01

    We present and investigate a simple way to generate nonnormal data using linear combinations of independent generator (IG) variables. The simulated data have prespecified univariate skewness and kurtosis and a given covariance matrix. In contrast to the widely used Vale-Maurelli (VM) transform, the obtained data are shown to have a non-Gaussian copula. We analytically obtain asymptotic robustness conditions for the IG distribution. We show empirically that popular test statistics in covariance analysis tend to reject true models more often under the IG transform than under the VM transform. This implies that overly optimistic evaluations of estimators and fit statistics in covariance structure analysis may be tempered by including the IG transform for nonnormal data generation. We provide an implementation of the IG transform in the R environment.

  20. Extrinsic Spin Hall Effect Induced by Resonant Skew Scattering in Graphene

    NASA Astrophysics Data System (ADS)

    Ferreira, Aires; Rappoport, Tatiana G.; Cazalilla, Miguel A.; Castro Neto, A. H.

    2015-03-01

    We show that the extrinsic spin Hall effect can be engineered in monolayer graphene by decoration with small doses of adatoms, molecules, or nanoparticles originating local spin-orbit perturbations. The analysis of the single impurity scattering problem shows that intrinsic and Rashba spin-orbit local couplings enhance the spin Hall effect via skew scattering of charge carriers in the resonant regime. The solution of the transport equations for a random ensemble of spin-orbit impurities reveals that giant spin Hall currents are within the reach of the current state of the art in device fabrication. The spin Hall effect is robust with respect to thermal fluctuations and disorder averaging. The author acknowledges support from the National Research Foundation-Competitive Research Programme through Grant No. R-144-000-295-281.

  1. The Modified Concorde Position with an Intraoperative Skew Head Rotation: Technical Note

    PubMed Central

    TAKASUNA, Hiroshi; TANAKA, Yuichiro

    2015-01-01

    The Concorde position was developed to approach pineal and cerebellar lesions with a midline suboccipital craniotomy. The neutral head position is needed to divide the occipital muscles symmetrically. The patient’s head is tilted to the right and the face is turned to the right for the microscopic procedure to keep the midline of the patient’s head axis straight in the surgical field for comfortable and accurate surgical manipulation. However, intraoperative repositioning of the patient’s head is somewhat difficult to release the holding arm of the Sugita head holder in the original method. We found that a skew head rotation by fixing the head asymmetrically in the Sugita head holder is very quick and convenient to obtain the optimal head position both for a craniotomy and a microscopic procedure. PMID:26226983

  2. The Modified Concorde Position with an Intraoperative Skew Head Rotation: Technical Note.

    PubMed

    Takasuna, Hiroshi; Tanaka, Yuichiro

    2015-01-01

    The Concorde position was developed to approach pineal and cerebellar lesions with a midline suboccipital craniotomy. The neutral head position is needed to divide the occipital muscles symmetrically. The patient's head is tilted to the right and the face is turned to the right for the microscopic procedure to keep the midline of the patient's head axis straight in the surgical field for comfortable and accurate surgical manipulation. However, intraoperative repositioning of the patient's head is somewhat difficult to release the holding arm of the Sugita head holder in the original method. We found that a skew head rotation by fixing the head asymmetrically in the Sugita head holder is very quick and convenient to obtain the optimal head position both for a craniotomy and a microscopic procedure.

  3. Two generalized Wigner-Yanase skew information and their uncertainty relations

    NASA Astrophysics Data System (ADS)

    Chen, Zheng-Li; Liang, Li-Li; Li, Hao-Jing; Wang, Wen-Hua

    2016-09-01

    In this paper, we first define two generalized Wigner-Yanase skew information |K_{ρ ,α }|(A) and |L_{ρ ,α }|(A) for any non-Hermitian Hilbert-Schmidt operator A and a density operator ρ on a Hilbert space H and discuss some properties of them, respectively. We also introduce two related quantities |S_{ρ ,α }|(A) and |T_{ρ ,α }|(A) . Then, we establish two uncertainty relations in terms of |W_{ρ ,α }|(A) and |widetilde{W}_{ρ ,α }|(A) , which read |W_{ρ ,α }|(A)|W_{ρ ,α }|(B)≥ 1/4| {tr}( [ ρ ^{α }+ρ ^{1-α }/2 ] 2[A,B]0) | 2, √{|widetilde{W}_{ρ ,α }|(A)| widetilde{W}_{ρ ,α }|(B)}≥ 1/4 | {tr}( ρ ^{2α }[A,B]0) {tr} ( ρ ^{2(1-α )}[A,B]0) | .

  4. Low paternity skew and the influence of maternal kin in an egalitarian, patrilocal primate

    PubMed Central

    Strier, Karen B.; Chaves, Paulo B.; Mendes, Sérgio L.; Fagundes, Valéria; Di Fiore, Anthony

    2011-01-01

    Levels of reproductive skew vary in wild primates living in multimale groups depending on the degree to which high-ranking males monopolize access to females. Still, the factors affecting paternity in egalitarian societies remain unexplored. We combine unique behavioral, life history, and genetic data to evaluate the distribution of paternity in the northern muriqui (Brachyteles hypoxanthus), a species known for its affiliative, nonhierarchical relationships. We genotyped 67 individuals (22 infants born over a 3-y period, their 21 mothers, and all 24 possible sires) at 17 microsatellite marker loci and assigned paternity to all infants. None of the 13 fathers were close maternal relatives of females with which they sired infants, and the most successful male sired a much lower percentage of infants (18%) than reported for the most successful males in other species. Our findings of inbreeding avoidance and low male reproductive skew are consistent with the muriqui's observed social and sexual behavior, but the long delay (≥2.08 y) between the onset of male sexual behavior and the age at which males first sire young is unexpected. The allocation of paternity implicates individual male life histories and access to maternal kin as key factors influencing variation in paternal—and grandmaternal—fitness. The apparent importance of lifelong maternal investment in coresident sons resonates with other recent examinations of maternal influences on offspring reproduction. This importance also extends the implications of the “grandmother hypothesis” in human evolution to include the possible influence of mothers and other maternal kin on male reproductive success in patrilocal societies. PMID:22065786

  5. A missing model in reproductive skew theory: the bordered tug-of-war.

    PubMed

    Reeve, Hudson Kern; Shen, Sheng-Feng

    2006-05-30

    Models of reproductive skew can be classified into two groups: transactional models, in which group members yield shares of reproduction to each other in return for cooperation, and tug-of-war models, in which group members invest group resources in a tug-of-war over their respective reproductive shares. We synthesize these two models to yield a "bordered tug-of-war" model in which the internal tug-of-war is limited ("bordered") by the requirement that group members must achieve a certain amount of reproduction lest they pursue a noncooperative option leading to group breakup. Previous attempts to synthesize these two models did not allow for the fact that the tug-of-war will affect group output, which in turn feeds back on the reproductive payments required by group members to remain cooperative. The bordered tug-of-war model, which does not assume complete reproductive control by any individual and allows for conflict within groups, predicts that the degree of within-group selfishness will increase as the noncooperative options become less attractive, e.g., as ecological constraints on solitary breeding increase. When the noncooperative option involves fighting for the group resource (e.g., territory) and leaving if the fight is lost, the subordinate's overall share of reproduction is predicted to be independent of its relatedness to the dominant and to increase the greater its probability of winning the fight, the less the value of the territory, and the greater its personal payoff for leaving. The unique predictions of the bordered tug-of-war model may fit skew data from a number of species, including meerkats, lions, and wood mice.

  6. Ultra-High Energy Cosmic Rays: Composition, Early Air Shower Interactions, and Xmax Skewness

    NASA Astrophysics Data System (ADS)

    Stapleton, James

    The composition of Ultra-High Energy Cosmic Rays (UHECRs) is still not completely understood, and must be inferred from Extended Air Shower (EAS), particle cascades which they initiate upon entering the atmosphere. The atmospheric depth at which the shower contains the maximum number of particles ( Xmax) is the most composition-sensitive property of the air shower, but its interpretation is hindered by intrinsic statistical fluctuations in EAS development which cause distinct compositions to produce overlapping Xmax distributions as well as our limited knowledge at these energies of hadronic physics which strongly impacts the Xmax distribution's shape. These issues ultimately necessitate a variety of complementary approaches to interpreting UHECR composition from Xmax data. The current work advances these approaches by connecting X max skewness to the uncertainties above. The study of X max has historically focused only on the mean and standard deviation of its distribution, but skewness is shown here to be strongly related to both the statistical fluctuations in EAS development as well as the least-understood hadronic cross-sections in the air shower. This leads into a treatment of the Exponentially-Modified Gaussian (EMG) distribution, whose little-known properties make it very useful for Xmax analysis and for data analysis in general. A powerful method emerges which uses only descriptive statistics in a robust check for energy-dependent changes in UHECR mass or EAS development. The application of these analyses to X max data provides tantalizing clues concerning issues of critical importance, such as the relationship between Xmax and the 'ankle' break in the UHECR energy spectrum, or the inferred properties of the UHECR mass distribution and its strong dependence on hadronic model systematics.

  7. Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques

    SciTech Connect

    Morita, Daisuke; Miyamoto, Ayumi; Hattori, Yuki; Komori, Takaya; Nakamura, Takashi; Igarashi, Tatsuhiko; Harashima, Hideyoshi; Sugita, Masahiko

    2013-11-08

    Highlights: •Glucose monomycolate (GMM) is a marker glycolipid for active tuberculosis. •Tissue responses to GMM involved up-regulation of Th1-attracting chemokines. •Th1-skewed local responses were mounted at the GMM-injected tissue. -- Abstract: Trehalose 6,6′-dimycolate (TDM) is a major glycolipid of the cell wall of mycobacteria with remarkable adjuvant functions. To avoid detection by the host innate immune system, invading mycobacteria down-regulate the expression of TDM by utilizing host-derived glucose as a competitive substrate for their mycolyltransferases; however, this enzymatic reaction results in the concomitant biosynthesis of glucose monomycolate (GMM) which is recognized by the acquired immune system. GMM-specific, CD1-restricted T cell responses have been detected in the peripheral blood of infected human subjects and monkeys as well as in secondary lymphoid organs of small animals, such as guinea pigs and human CD1-transgenic mice. Nevertheless, it remains to be determined how tissues respond at the site where GMM is produced. Here we found that rhesus macaques vaccinated with Mycobacterium bovis bacillus Calmette–Guerin mounted a chemokine response in GMM-challenged skin that was favorable for recruiting T helper (Th)1 T cells. Indeed, the expression of interferon-γ, but not Th2 or Th17 cytokines, was prominent in the GMM-injected tissue. The GMM-elicited tissue response was also associated with the expression of monocyte/macrophage-attracting CC chemokines, such as CCL2, CCL4 and CCL8. Furthermore, the skin response to GMM involved the up-regulated expression of granulysin and perforin. Given that GMM is produced primarily by pathogenic mycobacteria proliferating within the host, the Th1-skewed tissue response to GMM may function efficiently at the site of infection.

  8. A missing model in reproductive skew theory: the bordered tug-of-war.

    PubMed

    Reeve, Hudson Kern; Shen, Sheng-Feng

    2006-05-30

    Models of reproductive skew can be classified into two groups: transactional models, in which group members yield shares of reproduction to each other in return for cooperation, and tug-of-war models, in which group members invest group resources in a tug-of-war over their respective reproductive shares. We synthesize these two models to yield a "bordered tug-of-war" model in which the internal tug-of-war is limited ("bordered") by the requirement that group members must achieve a certain amount of reproduction lest they pursue a noncooperative option leading to group breakup. Previous attempts to synthesize these two models did not allow for the fact that the tug-of-war will affect group output, which in turn feeds back on the reproductive payments required by group members to remain cooperative. The bordered tug-of-war model, which does not assume complete reproductive control by any individual and allows for conflict within groups, predicts that the degree of within-group selfishness will increase as the noncooperative options become less attractive, e.g., as ecological constraints on solitary breeding increase. When the noncooperative option involves fighting for the group resource (e.g., territory) and leaving if the fight is lost, the subordinate's overall share of reproduction is predicted to be independent of its relatedness to the dominant and to increase the greater its probability of winning the fight, the less the value of the territory, and the greater its personal payoff for leaving. The unique predictions of the bordered tug-of-war model may fit skew data from a number of species, including meerkats, lions, and wood mice. PMID:16717185

  9. Resonance multiphoton ionization and dissociation of dimethyl ether via the {\\skew1\\tilde{\\rm C}^{\\prime}}, {\\skew1\\tilde{\\rm C}} and \\tilde{\\rm B} states

    NASA Astrophysics Data System (ADS)

    Mejia-Ospino, E.; García, G.; Guerrero, A.; Alvarez, I.; Cisneros, C.

    2005-01-01

    The three-photon resonance four-photon ionization and dissociation spectra of dimethyl ether (DME) are presented in the wavelength range 450-550 nm at 1 nm intervals. The (3+1) REMPI spectra show three prominent bands corresponding to the \\tildeB \\leftarrow \\skew1\\tildeX, {\\skew1\\tildeC} \\leftarrow \\skew1\\tildeX and {\\skew1\\tildeC^{\\prime}} \\leftarrow \\skew1\\tildeX transitions with origins at 61 457 cm-1 (7.615 eV), 59 055 cm-1 (7.322 eV) and 58 010 cm-1 (7.194 eV), respectively. Several ionized species, CH3+, CHnO+ (n = 1-3) and CH3OCH3+, are observed in the region of wavelengths studied here. In order to compare the results, a shorter wavelength multiphoton dissociation and ionization of DME at 355 nm is also presented. At this wavelength, DME undergoes neutral dissociation to CH3 and CH3O and each fragment is then ionized by multiphoton absorption. The fragmentation at 355 nm is very intense and only small fragments such as CH3+, CHO+, CH2+, CH+ and C+ ions are observed. The measurement of photoelectron energy allows us to establish that the DME ionization potential is at least 9.55 ± 0.15 eV. The experiments were performed using a Nd:YAG-OPO (optical parametric oscillator) tunable laser system coupled to a time-of-flight mass spectrometer and a hemispherical electron energy analyser.

  10. Genetic variation in nuclear and mitochondrial markers supports a large sex difference in lifetime reproductive skew in a lekking species

    PubMed Central

    Verkuil, Yvonne I; Juillet, Cedric; Lank, David B; Widemo, Fredrik; Piersma, Theunis

    2014-01-01

    Sex differences in skews of vertebrate lifetime reproductive success are difficult to measure directly. Evolutionary histories of differential skew should be detectable in the genome. For example, male-biased skew should reduce variation in the biparentally inherited genome relative to the maternally inherited genome. We tested this approach in lek-breeding ruff (Class Aves, Philomachus pugnax) by comparing genetic variation of nuclear microsatellites (θn; biparental) versus mitochondrial D-loop sequences (θm; maternal), and conversion to comparable nuclear (Ne) and female (Nef) effective population size using published ranges of mutation rates for each marker (μ). We provide a Bayesian method to calculate Ne (θn = 4Neμn) and Nef (θm = 2Nefμm) using 95% credible intervals (CI) of θn and θm as informative priors, and accounting for uncertainty in μ. In 96 male ruffs from one population, Ne was 97% (79–100%) lower than expected under random mating in an ideal population, where Ne:Nef = 2. This substantially lower autosomal variation represents the first genomic support of strong male reproductive skew in a lekking species. PMID:25478153

  11. Social Justice and South African University Student Enrolment Data by "Race", 1998-2012: From "Skewed Revolution" to "Stalled Revolution"

    ERIC Educational Resources Information Center

    Cooper, David

    2015-01-01

    The paper looks closely at student enrolment trends through a case study of South African "race" enrolment data, including some hypotheses about how student social class has influenced these trends. First, data on 1988-1998 enrolments showing a "skewed revolution" in student africanisation are summarised. Then, using 2000-2012…

  12. Determining the role of skewed X-chromosome inactivation in developing muscle symptoms in carriers of Duchenne muscular dystrophy.

    PubMed

    Viggiano, Emanuela; Ergoli, Manuela; Picillo, Esther; Politano, Luisa

    2016-07-01

    Duchenne and Becker dystrophinopathies (DMD and BMD) are X-linked recessive disorders caused by mutations in the dystrophin gene that lead to absent or reduced expression of dystrophin in both skeletal and heart muscles. DMD/BMD female carriers are usually asymptomatic, although about 8 % may exhibit muscle or cardiac symptoms. Several mechanisms leading to a reduced dystrophin have been hypothesized to explain the clinical manifestations and, in particular, the role of the skewed XCI is questioned. In this review, the mechanism of XCI and its involvement in the phenotype of BMD/DMD carriers with both a normal karyotype or with X;autosome translocations with breakpoints at Xp21 (locus of the DMD gene) will be analyzed. We have previously observed that DMD carriers with moderate/severe muscle involvement, exhibit a moderate or extremely skewed XCI, in particular if presenting with an early onset of symptoms, while DMD carriers with mild muscle involvement present a random XCI. Moreover, we found that among 87.1 % of the carriers with X;autosome translocations involving the locus Xp21 who developed signs and symptoms of dystrophinopathy such as proximal muscle weakness, difficulty to run, jump and climb stairs, 95.2 % had a skewed XCI pattern in lymphocytes. These data support the hypothesis that skewed XCI is involved in the onset of phenotype in DMD carriers, the X chromosome carrying the normal DMD gene being preferentially inactivated and leading to a moderate-severe muscle involvement. PMID:27098336

  13. The role of semantics, pre-emption and skew in linguistic distributions: the case of the un-construction

    PubMed Central

    Ibbotson, Paul

    2013-01-01

    We use the Google Ngram database, a corpus of 5,195,769 digitized books containing ~4% of all books ever published, to test three ideas that are hypothesized to account for linguistic generalizations: verbal semantics, pre-emption and skew. Using 828,813 tokens of un-forms as a test case for these mechanisms, we found verbal semantics was a good predictor of the frequency of un-forms in the English language over the past 200 years—both in terms of how the frequency changed over time and their frequency rank. We did not find strong evidence for the direct competition of un-forms and their top pre-emptors, however the skew of the un-construction competitors was inversely correlated with the acceptability of the un-form. We suggest a cognitive explanation for this, namely, that the more the set of relevant pre-emptors is skewed then the more easily it is retrieved from memory. This suggests that it is not just the frequency of pre-emptive forms that must be taken into account when trying to explain usage patterns but their skew as well. PMID:24399991

  14. Multiple paternity in an aggregate breeding amphibian: the effect of reproductive skew on estimates of male reproductive success.

    PubMed

    Myers, E M; Zamudio, K R

    2004-07-01

    Aggregate, or explosive, breeding is widespread among vertebrates and likely increases the probability of multiple paternity. We assessed paternity in seven field-collected clutches of the explosively breeding spotted salamander (Ambystoma maculatum) using 10 microsatellite loci to determine the frequency of multiple paternity and the number of males contributing to a female's clutch. Using the Minimum Method of allele counts, multiple paternity was evident in 70% of these egg masses. Simple allele counts underestimate the number of contributing males because this method cannot distinguish multiple fathers with common or similar alleles. Therefore, we used computer simulations to estimate from the offspring genotypes the most likely number of contributing fathers given the distributions of allele frequencies in this population. We determined that two to eight males may contribute to A. maculatum clutches; therefore, multiple paternity is a common strategy in this aggregate breeding species. In aggregate mating systems competition for mates can be intense, thus differential reproductive success (reproductive skew) among males contributing to a female's clutch could be a probable outcome. We use our data to evaluate the potential effect of reproductive skew on estimates of the number of contributing males. We simulated varying scenarios of differential male reproductive success, ranging from equal contribution to high reproductive skew among contributing sires in multiply sired clutches. Our data suggest that even intermediate levels of reproductive skew decrease confidence substantially in estimates of the number of contributing sires when parental genotypes are unknown. PMID:15189216

  15. On the Empirical Importance of the Conditional Skewness Assumption in Modelling the Relationship between Risk and Return

    NASA Astrophysics Data System (ADS)

    Pipień, M.

    2008-09-01

    We present the results of an application of Bayesian inference in testing the relation between risk and return on the financial instruments. On the basis of the Intertemporal Capital Asset Pricing Model, proposed by Merton we built a general sampling distribution suitable in analysing this relationship. The most important feature of our assumptions is that the skewness of the conditional distribution of returns is used as an alternative source of relation between risk and return. This general specification relates to Skewed Generalized Autoregressive Conditionally Heteroscedastic-in-Mean model. In order to make conditional distribution of financial returns skewed we considered the unified approach based on the inverse probability integral transformation. In particular, we applied hidden truncation mechanism, inverse scale factors, order statistics concept, Beta and Bernstein distribution transformations and also a constructive method. Based on the daily excess returns on the Warsaw Stock Exchange Index we checked the empirical importance of the conditional skewness assumption on the relation between risk and return on the Warsaw Stock Market. We present posterior probabilities of all competing specifications as well as the posterior analysis of the positive sign of the tested relationship.

  16. Association of skewed X chromosome inactivation and idiopathic recurrent spontaneous abortion: a systematic review and meta-analysis.

    PubMed

    Sui, Yilun; Chen, Qianqian; Sun, Xiaoxi

    2015-08-01

    Evidence of an association between skewed X chromosome inactivation (SXCI) and idiopathic recurrent spontaneous abortion (RSA) is conflicting. No consensus has been reached on the degree of SXCI and the number of pregnancy losses in patients who have experienced RSA. In this systematic review and meta-analysis, different degrees of skewing and definitions of RSA are used to establish an association between SXCI and idiopathic RSA. Twelve studies comprising 1594 women who had experienced RSA and 1924 controls were included. No significant association was found between SXCI and RSA when 80 or 90% was used as cut-off value of skewing; more stringent 95% or greater SXCI was significantly higher in women who had experienced RSA than in controls (odds ratio [OR] = 4.27, 95% confidence interval [CI] 1.46 to 12.46). A significantly higher incidence of SXCI when defined as greater than 90% (or ≥90%) was found in women who had experienced RSA with three or more pregnancy losses (OR = 2.31, 95% CI 1.41, 3.78); significance diminished when RSA was defined as two or more losses. Extreme skewing of SXCI is associated with idiopathic RSA with three or more losses. More studies are needed to validate the potential genetic mechanism.

  17. Numerical solution for the velocity-derivative skewness of a low Reynolds-number turbulent-like decaying Navier-Stokes flow

    NASA Technical Reports Server (NTRS)

    Deissler, Robert G.

    1991-01-01

    The variation of the velocity-derivative skewness of a Navier-Stokes flow as the Reynolds number goes toward zero is calculated numerically. The value of the skewness, which has been somewhat controversial, is shown to become small at low Reynolds numbers.

  18. Bayesian WLS/GLS regression for regional skewness analysis for regions with large crest stage gage networks

    USGS Publications Warehouse

    Veilleux, Andrea G.; Stedinger, Jery R.; Eash, David A.

    2012-01-01

    This paper summarizes methodological advances in regional log-space skewness analyses that support flood-frequency analysis with the log Pearson Type III (LP3) distribution. A Bayesian Weighted Least Squares/Generalized Least Squares (B-WLS/B-GLS) methodology that relates observed skewness coefficient estimators to basin characteristics in conjunction with diagnostic statistics represents an extension of the previously developed B-GLS methodology. B-WLS/B-GLS has been shown to be effective in two California studies. B-WLS/B-GLS uses B-WLS to generate stable estimators of model parameters and B-GLS to estimate the precision of those B-WLS regression parameters, as well as the precision of the model. The study described here employs this methodology to develop a regional skewness model for the State of Iowa. To provide cost effective peak-flow data for smaller drainage basins in Iowa, the U.S. Geological Survey operates a large network of crest stage gages (CSGs) that only record flow values above an identified recording threshold (thus producing a censored data record). CSGs are different from continuous-record gages, which record almost all flow values and have been used in previous B-GLS and B-WLS/B-GLS regional skewness studies. The complexity of analyzing a large CSG network is addressed by using the B-WLS/B-GLS framework along with the Expected Moments Algorithm (EMA). Because EMA allows for the censoring of low outliers, as well as the use of estimated interval discharges for missing, censored, and historic data, it complicates the calculations of effective record length (and effective concurrent record length) used to describe the precision of sample estimators because the peak discharges are no longer solely represented by single values. Thus new record length calculations were developed. The regional skewness analysis for the State of Iowa illustrates the value of the new B-WLS/BGLS methodology with these new extensions.

  19. Effect of velocity profile skewing on blood velocity and volume flow waveforms derived from maximum Doppler spectral velocity.

    PubMed

    Mynard, Jonathan P; Steinman, David A

    2013-05-01

    Given evidence that fully developed axisymmetric flow may be the exception rather than the rule, even in nominally straight arteries, maximum velocity (V(max)) can lie outside the Doppler sample volume (SV). The link between V(max) and derived quantities, such as volume flow (Q), may therefore be more complex than commonly thought. We performed idealized virtual Doppler ultrasound on data from image-based computational fluid dynamics (CFD) models of the normal human carotid artery and investigated how velocity profile skewing and choice of sample volume affected V(max) waveforms and derived Q variables, considering common assumptions about velocity profile shape (i.e., Poiseuille or Womersley). Severe velocity profile skewing caused substantial errors in V(max) waveforms when using a small, centered SV, although peak V(max) was reliably detected; errors with a long SV covering the vessel diameter were orientation dependent but lower overall. Cycle-averaged Q calculated from V(max) was typically within ±15%, although substantial skewing and use of a small SV caused 10%-25% underestimation. Peak Q derived from Womersley's theory was generally accurate to within ±10%. V(max) pulsatility and resistance indexes differed from Q-based values, although the Q-based resistance index could be predicted reliably. Skewing introduced significant error into V(max)-derived Q waveforms, particularly during mid-to-late systole. Our findings suggest that errors in the V(max) and Q waveforms related to velocity profile skewing and use of a small SV, or orientation-dependent errors for a long SV, could limit their use in wave analysis or for constructing characteristic or patient-specific flow boundary conditions for model studies.

  20. NPIP: A skew line needle configuration optimization system for HDR brachytherapy

    SciTech Connect

    Siauw, Timmy; Cunha, Adam; Berenson, Dmitry; Atamtuerk, Alper; Hsu, I-Chow; Goldberg, Ken; Pouliot, Jean

    2012-07-15

    Purpose: In this study, the authors introduce skew line needle configurations for high dose rate (HDR) brachytherapy and needle planning by integer program (NPIP), a computational method for generating these configurations. NPIP generates needle configurations that are specific to the anatomy of the patient, avoid critical structures near the penile bulb and other healthy structures, and avoid needle collisions inside the body. Methods: NPIP consisted of three major components: a method for generating a set of candidate needles, a needle selection component that chose a candidate needle subset to be inserted, and a dose planner for verifying that the final needle configuration could meet dose objectives. NPIP was used to compute needle configurations for prostate cancer data sets from patients previously treated at our clinic. NPIP took two user-parameters: a number of candidate needles, and needle coverage radius, {delta}. The candidate needle set consisted of 5000 needles, and a range of {delta} values was used to compute different needle configurations for each patient. Dose plans were computed for each needle configuration. The number of needles generated and dosimetry were analyzed and compared to the physician implant. Results: NPIP computed at least one needle configuration for every patient that met dose objectives, avoided healthy structures and needle collisions, and used as many or fewer needles than standard practice. These needle configurations corresponded to a narrow range of {delta} values, which could be used as default values if this system is used in practice. The average end-to-end runtime for this implementation of NPIP was 286 s, but there was a wide variation from case to case. Conclusions: The authors have shown that NPIP can automatically generate skew line needle configurations with the aforementioned properties, and that given the correct input parameters, NPIP can generate needle configurations which meet dose objectives and use as many

  1. Viruses-to-mobile genetic elements skew in the deep Atlantis II brine pool sediments.

    PubMed

    Adel, Mustafa; Elbehery, Ali H A; Aziz, Sherry K; Aziz, Ramy K; Grossart, Hans-Peter; Siam, Rania

    2016-01-01

    The central rift of the Red Sea has 25 brine pools with different physical and geochemical characteristics. Atlantis II (ATIID), Discovery Deeps (DD) and Chain Deep (CD) are characterized by high salinity, temperature and metal content. Several studies reported microbial communities in these brine pools, but few studies addressed the brine pool sediments. Therefore, sediment cores were collected from ATIID, DD, CD brine pools and an adjacent brine-influenced site. Sixteen different lithologic sediment sections were subjected to shotgun DNA pyrosequencing to generate 1.47 billion base pairs (1.47 × 10(9) bp). We generated sediment-specific reads and attempted to annotate all reads. We report the phylogenetic and biochemical uniqueness of the deepest ATIID sulfur-rich brine pool sediments. In contrary to all other sediment sections, bacteria dominate the deepest ATIID sulfur-rich brine pool sediments. This decrease in virus-to-bacteria ratio in selected sections and depth coincided with an overrepresentation of mobile genetic elements. Skewing in the composition of viruses-to-mobile genetic elements may uniquely contribute to the distinct microbial consortium in sediments in proximity to hydrothermally active vents of the Red Sea and possibly in their surroundings, through differential horizontal gene transfer. PMID:27596223

  2. Effect of Slot Combination and Skewed Slot on Electromagnetic Vibration of Capacitor Motor under Load

    NASA Astrophysics Data System (ADS)

    Hirotsuka, Isao; Tsuboi, Kazuo

    The capacitor motor (CRM) is widely used to drive industrial equipments and electric home appliances. Recently, the reduction in the vibration and noise of the CRM has become increasingly important from the standpoint of environmental improvement. However, the electromagnetic vibration of the CRM under load has not been analyzed sufficiently. Therefore, we have studied the electromagnetic vibration of CRM for the purpose of reducing it. In a previous paper, the relationships for a backward magnetic field, the equivalent circuit current, and the vibration of the CRM were clarified. The present paper theoretically and experimentally discusses the effect of the slot combination and skewed slot on the electromagnetic vibration of CRM under load. The primary conclusions are as follows: (1) In the case of 4-pole and 6-pole CRMs, the dominant electromagnetic vibration of CRMs was theoretically attributed to three types of electromagnetic force waves. Two types of electromagnetic force waves are generated: one wave is generated by the interaction of two forward magnetic fluxes, such as those of a three-phase squirrel-cage induction motor, and the other wave is generated under the influence of a backward magnetic flux. (2) The characteristics of dominant electromagnetic vibration depending on load and running capacitor were classified theoretically and experimentally into three types based on the characteristics of the electromagnetic force wave and equivalent circuit current. (3) The influences of magnetic saturation in dominant electromagnetic vibration were verified experimentally and their causes were clarified theoretically in relation to electromagnetic force waves.

  3. Gluten-containing grains skew gluten assessment in oats due to sample grind non-homogeneity.

    PubMed

    Fritz, Ronald D; Chen, Yumin; Contreras, Veronica

    2017-02-01

    Oats are easily contaminated with gluten-rich kernels of wheat, rye and barley. These contaminants are like gluten 'pills', shown here to skew gluten analysis results. Using R-Biopharm R5 ELISA, we quantified gluten in gluten-free oatmeal servings from an in-market survey. For samples with a 5-20ppm reading on a first test, replicate analyses provided results ranging <5ppm to >160ppm. This suggests sample grinding may inadequately disperse gluten to allow a single accurate gluten assessment. To ascertain this, and characterize the distribution of 0.25-g gluten test results for kernel contaminated oats, twelve 50g samples of pure oats, each spiked with a wheat kernel, showed that 0.25g test results followed log-normal-like distributions. With this, we estimate probabilities of mis-assessment for a 'single measure/sample' relative to the <20ppm regulatory threshold, and derive an equation relating the probability of mis-assessment to sample average gluten content.

  4. Skew of mantle upwelling beneath the East Pacific Rise governs segmentation.

    PubMed

    Toomey, Douglas R; Jousselin, David; Dunn, Robert A; Wilcock, William S D; Detrick, R S

    2007-03-22

    Mantle upwelling is essential to the generation of new oceanic crust at mid-ocean ridges, and it is generally assumed that such upwelling is symmetric beneath active ridges. Here, however, we use seismic imaging to show that the isotropic and anisotropic structure of the mantle is rotated beneath the East Pacific Rise. The isotropic structure defines the pattern of magma delivery from the mantle to the crust. We find that the segmentation of the rise crest between transform faults correlates well with the distribution of mantle melt. The azimuth of seismic anisotropy constrains the direction of mantle flow, which is rotated nearly 10 degrees anticlockwise from the plate-spreading direction. The mismatch between the locus of mantle melt delivery and the morphologic ridge axis results in systematic differences between areas of on-axis and off-axis melt supply. We conclude that the skew of asthenospheric upwelling and transport governs segmentation of the East Pacific Rise and variations in the intensity of ridge crest processes. PMID:17377578

  5. Application of derivative matrices of skew rays to design of compound dispersion prisms.

    PubMed

    Lin, Psang Dain

    2016-09-01

    Numerous optimization methods have been developed in recent decades for optical system design. However, these methods rely heavily on ray tracing and finite difference techniques to estimate the derivative matrices of the rays. Consequently, the accuracy of the results obtained from these methods is critically dependent on the incremental step size used in the tuning stage. To overcome this limitation, the present study proposes a comprehensive methodology for the design of compound dispersion prisms based on the first- and second-order derivative matrices of skew rays. The proposed method facilitates the analysis and design of prisms with respect to arbitrary system variables and provides an ideal basis for automatic prism design applications. Four illustrative examples are given. It is shown that the optical quantities required to evaluate the prism performance can be extracted directly from the proposed derivative matrices. In addition, it is shown in this study that the single-element 3D prism can have the same deviation angle and spectral dispersion as the 2D compound prism. PMID:27607509

  6. Effect of phase response curve skewness on synchronization of electrically coupled neuronal oscillators.

    PubMed

    Dodla, Ramana; Wilson, Charles J

    2013-10-01

    We investigate why electrically coupled neuronal oscillators synchronize or fail to synchronize using the theory of weakly coupled oscillators. Stability of synchrony and antisynchrony is predicted analytically and verified using numerical bifurcation diagrams. The shape of the phase response curve (PRC), the shape of the voltage time course, and the frequency of spiking are freely varied to map out regions of parameter spaces that hold stable solutions. We find that type 1 and type 2 PRCs can hold both synchronous and antisynchronous solutions, but the shape of the PRC and the voltage determine the extent of their stability. This is achieved by introducing a five-piecewise linear model to the PRC and a three-piecewise linear model to the voltage time course, and then analyzing the resultant eigenvalue equations that determine the stability of the phase-locked solutions. A single time parameter defines the skewness of the PRC, and another single time parameter defines the spike width and frequency. Our approach gives a comprehensive picture of the relation of the PRC shape, voltage time course, and stability of the resultant synchronous and antisynchronous solutions.

  7. Strong reproductive skew among males in the multiply mated swordtail Xiphophorus multilineatus (Teleostei).

    PubMed

    Luo, J; Sanetra, M; Schartl, M; Meyer, A

    2005-01-01

    Male swordtails in the genus Xiphophorus display a conspicuous ventral elongation of the caudal fin, the sword, which arose through sexual selection due to female preference. Females mate regularly and are able to store sperm for at least 6 months. If multiple mating is frequent, this would raise the intriguing question about the role of female choice and male-male competition in shaping the mating system of these fishes. Size-dependent alternate mating strategies occur in Xiphophorus; one such strategy is courtship with a sigmoid display by large dominant males, while the other is gonopodial thrusting, in which small subordinate males sneak copulations. Using microsatellite markers, we observed a frequency of multiple paternity in wild-caught Xiphophorus multilineatus in 28% of families analyzed, but the actual frequency of multiple mating suggested by the correction factor PrDM was 33%. The number of fathers contributing genetically to the brood ranged from one to three. Compared to other species in the family Poeciliidae, both frequency and degree of multiple paternity were low. Paternity was found to be highly skewed, with one male on average contributing more than 70% to the offspring. Hence in this Xiphophorus mating system, typically one male dominates and sneaker males do not appear to be particularly effective. Postcopulatory mechanisms, however, such as sperm competition, are also indicated by our data, using sex-linked phenotypes among the offspring. PMID:15743903

  8. Allele-Skewed DNA Modification in the Brain: Relevance to a Schizophrenia GWAS.

    PubMed

    Gagliano, Sarah A; Ptak, Carolyn; Mak, Denise Y F; Shamsi, Mehrdad; Oh, Gabriel; Knight, Joanne; Boutros, Paul C; Petronis, Arturas

    2016-05-01

    Numerous recent studies have suggested that phenotypic effects of DNA sequence variants can be mediated or modulated by their epigenetic marks, such as allele-skewed DNA modification (ASM). Using Affymetrix SNP microarrays, we performed a comprehensive search of ASM effects in human post-mortem brain and sperm samples (total n = 256) from individuals with major psychosis and control individuals. Depending on the phenotypic category of the brain samples, 1.4%-7.5% of interrogated SNPs exhibited ASM effects. Next, we investigated ASM in the context of genetic studies of schizophrenia and detected that brain ASM SNPs were significantly overrepresented among sub-threshold SNPs from a schizophrenia genome-wide association study (GWAS). Brain ASM SNPs showed a much stronger enrichment in a schizophrenia GWAS than in 17 large GWASs of non-psychiatric diseases and traits, arguing that ASM effects are at least partially tissue specific. Studies of germline and control brain ASM SNPs supported a causal association between ASM and schizophrenia. Finally, significantly higher proportions of ASM SNPs than of non-ASM SNPs were detected at loci exhibiting epigenetic signatures of enhancers and promoters, and they were overrepresented within transcription factor binding regions and DNase I hypersensitive sites. All of these findings collectively indicate that ASM SNPs should be prioritized in follow-up GWASs. PMID:27087318

  9. Skewed Riskscapes and Gentrified Inequities: Environmental Exposure Disparities in Seattle, Washington

    PubMed Central

    White, Jonah

    2011-01-01

    Objectives. Few studies have considered the sociohistorical intersection of environmental injustice and gentrification; a gap addressed by this case study of Seattle, Washington. This study explored the advantages of integrating air toxic risk screening with gentrification research to enhance proximity and health equity analysis methodologies. It was hypothesized that Seattle's industrial air toxic exposure risk was unevenly dispersed, that gentrification stratified the city's neighborhoods, and that the inequities of both converged. Methods. Spatial characterizations of air toxic pollution risk exposures from 1990 to 2007 were combined with longitudinal cluster analysis of census block groups in Seattle, Washington, from 1990 to 2000. Results. A cluster of air toxic exposure inequality and socioeconomic inequity converged in 1 area of south central Seattle. Minority and working class residents were more concentrated in the same neighborhoods near Seattle's worst industrial pollution risks. Conclusions. Not all pollution was distributed equally in a dynamic urban landscape. Using techniques to examine skewed riskscapes and socioeconomic urban geographies provided a foundation for future research on the connections among environmental health hazard sources, socially vulnerable neighborhoods, and health inequity. PMID:21836115

  10. Viruses-to-mobile genetic elements skew in the deep Atlantis II brine pool sediments

    NASA Astrophysics Data System (ADS)

    Adel, Mustafa; Elbehery, Ali H. A.; Aziz, Sherry K.; Aziz, Ramy K.; Grossart, Hans-Peter; Siam, Rania

    2016-09-01

    The central rift of the Red Sea has 25 brine pools with different physical and geochemical characteristics. Atlantis II (ATIID), Discovery Deeps (DD) and Chain Deep (CD) are characterized by high salinity, temperature and metal content. Several studies reported microbial communities in these brine pools, but few studies addressed the brine pool sediments. Therefore, sediment cores were collected from ATIID, DD, CD brine pools and an adjacent brine-influenced site. Sixteen different lithologic sediment sections were subjected to shotgun DNA pyrosequencing to generate 1.47 billion base pairs (1.47 × 109 bp). We generated sediment-specific reads and attempted to annotate all reads. We report the phylogenetic and biochemical uniqueness of the deepest ATIID sulfur-rich brine pool sediments. In contrary to all other sediment sections, bacteria dominate the deepest ATIID sulfur-rich brine pool sediments. This decrease in virus-to-bacteria ratio in selected sections and depth coincided with an overrepresentation of mobile genetic elements. Skewing in the composition of viruses-to-mobile genetic elements may uniquely contribute to the distinct microbial consortium in sediments in proximity to hydrothermally active vents of the Red Sea and possibly in their surroundings, through differential horizontal gene transfer.

  11. Gluten-containing grains skew gluten assessment in oats due to sample grind non-homogeneity.

    PubMed

    Fritz, Ronald D; Chen, Yumin; Contreras, Veronica

    2017-02-01

    Oats are easily contaminated with gluten-rich kernels of wheat, rye and barley. These contaminants are like gluten 'pills', shown here to skew gluten analysis results. Using R-Biopharm R5 ELISA, we quantified gluten in gluten-free oatmeal servings from an in-market survey. For samples with a 5-20ppm reading on a first test, replicate analyses provided results ranging <5ppm to >160ppm. This suggests sample grinding may inadequately disperse gluten to allow a single accurate gluten assessment. To ascertain this, and characterize the distribution of 0.25-g gluten test results for kernel contaminated oats, twelve 50g samples of pure oats, each spiked with a wheat kernel, showed that 0.25g test results followed log-normal-like distributions. With this, we estimate probabilities of mis-assessment for a 'single measure/sample' relative to the <20ppm regulatory threshold, and derive an equation relating the probability of mis-assessment to sample average gluten content. PMID:27596406

  12. A Timing Estimation Method Based-on Skewness Analysis in Vehicular Wireless Networks.

    PubMed

    Cui, Xuerong; Li, Juan; Wu, Chunlei; Liu, Jian-Hang

    2015-01-01

    Vehicle positioning technology has drawn more and more attention in vehicular wireless networks to reduce transportation time and traffic accidents. Nowadays, global navigation satellite systems (GNSS) are widely used in land vehicle positioning, but most of them are lack precision and reliability in situations where their signals are blocked. Positioning systems base-on short range wireless communication are another effective way that can be used in vehicle positioning or vehicle ranging. IEEE 802.11p is a new real-time short range wireless communication standard for vehicles, so a new method is proposed to estimate the time delay or ranges between vehicles based on the IEEE 802.11p standard which includes three main steps: cross-correlation between the received signal and the short preamble, summing up the correlated results in groups, and finding the maximum peak using a dynamic threshold based on the skewness analysis. With the range between each vehicle or road-side infrastructure, the position of neighboring vehicles can be estimated correctly. Simulation results were presented in the International Telecommunications Union (ITU) vehicular multipath channel, which show that the proposed method provides better precision than some well-known timing estimation techniques, especially in low signal to noise ratio (SNR) environments. PMID:26580628

  13. Natural frequencies of thick, symmetrically-laminated, skew, trapezoidal plates with various boundary supports

    SciTech Connect

    Kapania, R.K.; Lovejoy, A.E.

    1994-12-31

    Increasing use of composite materials in structures requires an accurate method of predicting response. Transverse shear effects can play an important role in laminated structures, even those that are considered thin, and as a result, should not be neglected. The free vibration response of generally laminated, thick, skewed, trapezoidal plates is investigated due of the lack of information in this area. In the method developed, Chebychev polynomials are used as displacement functions in the Rayleigh-Ritz method. To account for various edge supports, free, simply supported, and clamped, appropriate linear and rotational springs are introduced to satisfy the essential boundary conditions. First-order shear theory is used to account for transverse shear effects, and rotary inertia is also included in the model. Convergence of the solution resulting from changes in spring values and number of terms in the series is investigated. To demonstrate the accuracy of the method, results for thin isotropic and laminated plates are compared to past results for various planforms and boundary conditions. Next, thick isotropic plate results are compared to available published results. Thick laminated plate results for various planforms and boundary conditions are then presented. Variations in natural frequencies due to geometric parameter changes, such as taper ratio and sweep angle, are also studied.

  14. A Timing Estimation Method Based-on Skewness Analysis in Vehicular Wireless Networks

    PubMed Central

    Cui, Xuerong; Li, Juan; Wu, Chunlei; Liu, Jian-Hang

    2015-01-01

    Vehicle positioning technology has drawn more and more attention in vehicular wireless networks to reduce transportation time and traffic accidents. Nowadays, global navigation satellite systems (GNSS) are widely used in land vehicle positioning, but most of them are lack precision and reliability in situations where their signals are blocked. Positioning systems base-on short range wireless communication are another effective way that can be used in vehicle positioning or vehicle ranging. IEEE 802.11p is a new real-time short range wireless communication standard for vehicles, so a new method is proposed to estimate the time delay or ranges between vehicles based on the IEEE 802.11p standard which includes three main steps: cross-correlation between the received signal and the short preamble, summing up the correlated results in groups, and finding the maximum peak using a dynamic threshold based on the skewness analysis. With the range between each vehicle or road-side infrastructure, the position of neighboring vehicles can be estimated correctly. Simulation results were presented in the International Telecommunications Union (ITU) vehicular multipath channel, which show that the proposed method provides better precision than some well-known timing estimation techniques, especially in low signal to noise ratio (SNR) environments. PMID:26580628

  15. A measure of sexual selection in hermaphroditic animals: parentage skew and the opportunity for selection.

    PubMed

    Lorenzi, M C; Sella, G

    2008-05-01

    The role of sexual selection in shaping the mating system of hermaphrodites is currently widely accepted. However, a quantification of the intensity of sexual selection in hermaphroditic animals has never been accomplished. We evaluated the opportunity for sexual selection for both the female and the male functions in the simultaneous outcrossing hermaphrodite Ophryotrocha diadema by measuring focal hermaphrodites' paternal and maternal offspring in experimental replicated monogamous and promiscuous populations, using genetic markers to estimate paternity. Opportunity for sexual selection for each of the two sexual functions was quantified by means of the Crow's index, i.e. the ratio of variance in progeny number to the squared mean number of progeny. In addition, the extent to which the reproductive success was shared among competing individuals was estimated by means of the Nonacs's B index. We documented that the strength of selection on the male and female function in hermaphrodites with external fertilization depends on the reproductive context. Under a promiscuous regime, hermaphrodites have higher opportunities for selection for both the male and the female function than under the monogamous regime. Moreover, the reproductive skew for the female function becomes greater than that for the male function, moving from monogamy to promiscuity. In our model system, allocation to one sexual function is opposed by any degree of allocation to the other, indicating that sex-specific patterns of selection operate in this model species.

  16. Viruses-to-mobile genetic elements skew in the deep Atlantis II brine pool sediments.

    PubMed

    Adel, Mustafa; Elbehery, Ali H A; Aziz, Sherry K; Aziz, Ramy K; Grossart, Hans-Peter; Siam, Rania

    2016-09-06

    The central rift of the Red Sea has 25 brine pools with different physical and geochemical characteristics. Atlantis II (ATIID), Discovery Deeps (DD) and Chain Deep (CD) are characterized by high salinity, temperature and metal content. Several studies reported microbial communities in these brine pools, but few studies addressed the brine pool sediments. Therefore, sediment cores were collected from ATIID, DD, CD brine pools and an adjacent brine-influenced site. Sixteen different lithologic sediment sections were subjected to shotgun DNA pyrosequencing to generate 1.47 billion base pairs (1.47 × 10(9) bp). We generated sediment-specific reads and attempted to annotate all reads. We report the phylogenetic and biochemical uniqueness of the deepest ATIID sulfur-rich brine pool sediments. In contrary to all other sediment sections, bacteria dominate the deepest ATIID sulfur-rich brine pool sediments. This decrease in virus-to-bacteria ratio in selected sections and depth coincided with an overrepresentation of mobile genetic elements. Skewing in the composition of viruses-to-mobile genetic elements may uniquely contribute to the distinct microbial consortium in sediments in proximity to hydrothermally active vents of the Red Sea and possibly in their surroundings, through differential horizontal gene transfer.

  17. Failure detection and isolation investigation for strapdown skew redundant tetrad laser gyro inertial sensor arrays

    NASA Technical Reports Server (NTRS)

    Eberlein, A. J.; Lahm, T. G.

    1976-01-01

    The degree to which flight-critical failures in a strapdown laser gyro tetrad sensor assembly can be isolated in short-haul aircraft after a failure occurrence has been detected by the skewed sensor failure-detection voting logic is investigated along with the degree to which a failure in the tetrad computer can be detected and isolated at the computer level, assuming a dual-redundant computer configuration. The tetrad system was mechanized with two two-axis inertial navigation channels (INCs), each containing two gyro/accelerometer axes, computer, control circuitry, and input/output circuitry. Gyro/accelerometer data is crossfed between the two INCs to enable each computer to independently perform the navigation task. Computer calculations are synchronized between the computers so that calculated quantities are identical and may be compared. Fail-safe performance (identification of the first failure) is accomplished with a probability approaching 100 percent of the time, while fail-operational performance (identification and isolation of the first failure) is achieved 93 to 96 percent of the time.

  18. Viruses-to-mobile genetic elements skew in the deep Atlantis II brine pool sediments

    PubMed Central

    Adel, Mustafa; Elbehery, Ali H. A.; Aziz, Sherry K.; Aziz, Ramy K.; Grossart, Hans-Peter; Siam, Rania

    2016-01-01

    The central rift of the Red Sea has 25 brine pools with different physical and geochemical characteristics. Atlantis II (ATIID), Discovery Deeps (DD) and Chain Deep (CD) are characterized by high salinity, temperature and metal content. Several studies reported microbial communities in these brine pools, but few studies addressed the brine pool sediments. Therefore, sediment cores were collected from ATIID, DD, CD brine pools and an adjacent brine-influenced site. Sixteen different lithologic sediment sections were subjected to shotgun DNA pyrosequencing to generate 1.47 billion base pairs (1.47 × 109 bp). We generated sediment-specific reads and attempted to annotate all reads. We report the phylogenetic and biochemical uniqueness of the deepest ATIID sulfur-rich brine pool sediments. In contrary to all other sediment sections, bacteria dominate the deepest ATIID sulfur-rich brine pool sediments. This decrease in virus-to-bacteria ratio in selected sections and depth coincided with an overrepresentation of mobile genetic elements. Skewing in the composition of viruses-to-mobile genetic elements may uniquely contribute to the distinct microbial consortium in sediments in proximity to hydrothermally active vents of the Red Sea and possibly in their surroundings, through differential horizontal gene transfer. PMID:27596223

  19. Application of derivative matrices of skew rays to design of compound dispersion prisms.

    PubMed

    Lin, Psang Dain

    2016-09-01

    Numerous optimization methods have been developed in recent decades for optical system design. However, these methods rely heavily on ray tracing and finite difference techniques to estimate the derivative matrices of the rays. Consequently, the accuracy of the results obtained from these methods is critically dependent on the incremental step size used in the tuning stage. To overcome this limitation, the present study proposes a comprehensive methodology for the design of compound dispersion prisms based on the first- and second-order derivative matrices of skew rays. The proposed method facilitates the analysis and design of prisms with respect to arbitrary system variables and provides an ideal basis for automatic prism design applications. Four illustrative examples are given. It is shown that the optical quantities required to evaluate the prism performance can be extracted directly from the proposed derivative matrices. In addition, it is shown in this study that the single-element 3D prism can have the same deviation angle and spectral dispersion as the 2D compound prism.

  20. Skew of mantle upwelling beneath the East Pacific Rise governs segmentation.

    PubMed

    Toomey, Douglas R; Jousselin, David; Dunn, Robert A; Wilcock, William S D; Detrick, R S

    2007-03-22

    Mantle upwelling is essential to the generation of new oceanic crust at mid-ocean ridges, and it is generally assumed that such upwelling is symmetric beneath active ridges. Here, however, we use seismic imaging to show that the isotropic and anisotropic structure of the mantle is rotated beneath the East Pacific Rise. The isotropic structure defines the pattern of magma delivery from the mantle to the crust. We find that the segmentation of the rise crest between transform faults correlates well with the distribution of mantle melt. The azimuth of seismic anisotropy constrains the direction of mantle flow, which is rotated nearly 10 degrees anticlockwise from the plate-spreading direction. The mismatch between the locus of mantle melt delivery and the morphologic ridge axis results in systematic differences between areas of on-axis and off-axis melt supply. We conclude that the skew of asthenospheric upwelling and transport governs segmentation of the East Pacific Rise and variations in the intensity of ridge crest processes.

  1. Boundedness of the mixed velocity-temperature derivative skewness in homogeneous isotropic turbulence

    NASA Astrophysics Data System (ADS)

    Tang, S. L.; Antonia, R. A.; Djenidi, L.; Danaila, L.; Zhou, Y.

    2016-09-01

    The transport equation for the mean scalar dissipation rate ɛ ¯ θ is derived by applying the limit at small separations to the generalized form of Yaglom's equation in two types of flows, those dominated mainly by a decay of energy in the streamwise direction and those which are forced, through a continuous injection of energy at large scales. In grid turbulence, the imbalance between the production of ɛ ¯ θ due to stretching of the temperature field and the destruction of ɛ ¯ θ by the thermal diffusivity is governed by the streamwise advection of ɛ ¯ θ by the mean velocity. This imbalance is intrinsically different from that in stationary forced periodic box turbulence (or SFPBT), which is virtually negligible. In essence, the different types of imbalance represent different constraints imposed by the large-scale motion on the relation between the so-called mixed velocity-temperature derivative skewness ST and the scalar enstrophy destruction coefficient Gθ in different flows, thus resulting in non-universal approaches of ST towards a constant value as Reλ increases. The data for ST collected in grid turbulence and in SFPBT indicate that the magnitude of ST is bounded, this limit being close to 0.5.

  2. Improved estimates of the range of errors on photomasks using measured values of skewness and kurtosis

    NASA Astrophysics Data System (ADS)

    Hamaker, Henry Chris

    1995-12-01

    Statistical process control (SPC) techniques often use six times the standard deviation sigma to estimate the range of errors within a process. Two assumptions are inherent in this choice of metric for the range: (1) the normal distribution adequately describes the errors, and (2) the fraction of errors falling within plus or minus 3 sigma, about 99.73%, is sufficiently large that we may consider the fraction occurring outside this range to be negligible. In state-of-the-art photomasks, however, the assumption of normality frequently breaks down, and consequently plus or minus 3 sigma is not a good estimate of the range of errors. In this study, we show that improved estimates for the effective maximum error Em, which is defined as the value for which 99.73% of all errors fall within plus or minus Em of the mean mu, may be obtained by quantifying the deviation from normality of the error distributions using the skewness and kurtosis of the error sampling. Data are presented indicating that in laser reticle- writing tools, Em less than or equal to 3 sigma. We also extend this technique for estimating the range of errors to specifications that are usually described by mu plus 3 sigma. The implications for SPC are examined.

  3. Bayesian inference for a nonlinear mixed-effects Tobit model with multivariate skew-t distributions: application to AIDS studies.

    PubMed

    Dagne, Getachew; Huang, Yangxin

    2012-01-01

    Censored data are characteristics of many bioassays in HIV/AIDS studies where assays may not be sensitive enough to determine gradations in viral load determination among those below a detectable threshold. Not accounting for such left-censoring appropriately can lead to biased parameter estimates in most data analysis. To properly adjust for left-censoring, this paper presents an extension of the Tobit model for fitting nonlinear dynamic mixed-effects models with skew distributions. Such extensions allow one to specify the conditional distributions for viral load response to account for left-censoring, skewness and heaviness in the tails of the distributions of the response variable. A Bayesian modeling approach via Markov Chain Monte Carlo (MCMC) algorithm is used to estimate model parameters. The proposed methods are illustrated using real data from an HIV/AIDS study. PMID:22992288

  4. Development and Validation of a New Blade Element Momentum Skewed-Wake Model within AeroDyn: Preprint

    SciTech Connect

    Ning, S. A.; Hayman, G.; Damiani, R.; Jonkman, J.

    2014-12-01

    Blade element momentum methods, though conceptually simple, are highly useful for analyzing wind turbines aerodynamics and are widely used in many design and analysis applications. A new version of AeroDyn is being developed to take advantage of new robust solution methodologies, conform to a new modularization framework for National Renewable Energy Laboratory's FAST, utilize advanced skewed-wake analysis methods, fix limitations with previous implementations, and to enable modeling of highly flexible and nonstraight blades. This paper reviews blade element momentum theory and several of the options available for analyzing skewed inflow. AeroDyn implementation details are described for the benefit of users and developers. These new options are compared to solutions from the previous version of AeroDyn and to experimental data. Finally, recommendations are given on how one might select from the various available solution approaches.

  5. De novo MECP2 duplications in two females with intellectual disability and unfavorable complete skewed X-inactivation.

    PubMed

    Fieremans, Nathalie; Bauters, Marijke; Belet, Stefanie; Verbeeck, Jelle; Jansen, Anna C; Seneca, Sara; Roelens, Filip; De Baere, Elfride; Marynen, Peter; Froyen, Guy

    2014-11-01

    Xq28 microduplications of MECP2 are a prominent cause of a severe syndromic form of intellectual disability (ID) in males. Females are usually unaffected through near to complete X-inactivation of the aberrant X chromosome (skewing). In rare cases, affected females have been described due to random X-inactivation. Here, we report on two female patients carrying de novo MECP2 microduplications on their fully active X chromosomes. Both patients present with ID and additional clinical features. Mono-allelic expression confirmed complete skewing of X-inactivation. Consequently, significantly enhanced MECP2 mRNA levels were observed. We hypothesize that the cause for the complete skewing is due to a more harmful mutation on the other X chromosome, thereby forcing the MECP2 duplication to become active. However, we could not unequivocally identify such a second mutation by array-CGH or exome sequencing. Our data underline that, like in males, increased MECP2 dosage in females can contribute to ID too, which should be taken into account in diagnostics.

  6. Flow Style Investigation and Noise Reduction of a Cross-Flow Fan with Varied Rotor-Skew-Angle Rotor

    NASA Astrophysics Data System (ADS)

    Tsai, Go-Long; Tu, Tsung-Hsien; Li, Tung-Chen; Wang, Kuang-Hsieng

    The purpose of this study was investigating the noise emission, flow-style, fan’s performance regarding to cross-fan with three different rotor-skew angle (RSA) rotors. The special flow visualization setups for both vertical and parallel investigation of smoke slice were used to overcome the blind sight of a Laser-Doppler or a particle-tracking velocimeter, and the three-dimensional flow differences were confirmed with streamline images. The experimental results indicated that RSA-5, which is a rotor with a nearly a pitch skew within blade’s two end shrouds, has a lower sound emission and little pressure drops relative to that of no skew angle case, RSA-0. RSA-10, two pitches twisting case, also has a better acoustics quietness than that of RSA-0, but it excited undesired noise in a high frequency components around 2-4kHz. In this work, for a compromise between flow and acoustics performances, RSA-5 shows the most suitable design for cross-flow fan rotor.

  7. Skewness and Kurtosis of the Switching Current Distribution in Superconductor-Graphene-Superconductor Junctions and Superconductor-Nanowire-Superconductor Devices

    NASA Astrophysics Data System (ADS)

    Murphy, Andrew; Aref, Thomas; Coskun, Ulas; Weinberg, Phillip; Levchenko, Alex; Vakaryuk, Victor; Bezryadin, Alexey

    2013-03-01

    We study statistical properties of the switching current in superconductor-graphene-superconductor proximity junctions and superconductor-nanowire-superconductor devices. The fluctuations of the switching current are related to Little's phase slips, generated by thermal and quantum fluctuations of the superconducting order parameter. The study focuses on higher moments of the statistical probability distributions of the switching current. Namely we study the skewness, which defines the asymmetry of the distribution, and kurtosis, which is a measure of the ``peakedness.'' The skewness is defined as sk= m3 /m23 / 2 where m2 is the second moment of the distribution, called the variance, and m3 is the third moment. Kurtosis is defined as kur= m4 /m22 , where m4 is the fourth moment of the distribution. It is known that for Gaussian distributions sk=0 and kur=3. On our devices we find, in most cases, sk ~ -1 and kur ~ 5. These results are in agreement with numerical simulations as well as an analytic model. Finally we present preliminary experimental results for a two-nanowire device. We have found that the standard deviation, skewness and kurtosis of the switching current distributions in these devices vary periodically with magnetic field.

  8. Bayesian semiparametric nonlinear mixed-effects joint models for data with skewness, missing responses, and measurement errors in covariates.

    PubMed

    Huang, Yangxin; Dagne, Getachew

    2012-09-01

    It is a common practice to analyze complex longitudinal data using semiparametric nonlinear mixed-effects (SNLME) models with a normal distribution. Normality assumption of model errors may unrealistically obscure important features of subject variations. To partially explain between- and within-subject variations, covariates are usually introduced in such models, but some covariates may often be measured with substantial errors. Moreover, the responses may be missing and the missingness may be nonignorable. Inferential procedures can be complicated dramatically when data with skewness, missing values, and measurement error are observed. In the literature, there has been considerable interest in accommodating either skewness, incompleteness or covariate measurement error in such models, but there has been relatively little study concerning all three features simultaneously. In this article, our objective is to address the simultaneous impact of skewness, missingness, and covariate measurement error by jointly modeling the response and covariate processes based on a flexible Bayesian SNLME model. The method is illustrated using a real AIDS data set to compare potential models with various scenarios and different distribution specifications.

  9. Serotonin skews human macrophage polarization through HTR2B and HTR7.

    PubMed

    de las Casas-Engel, Mateo; Domínguez-Soto, Angeles; Sierra-Filardi, Elena; Bragado, Rafael; Nieto, Concha; Puig-Kroger, Amaya; Samaniego, Rafael; Loza, Mabel; Corcuera, María Teresa; Gómez-Aguado, Fernando; Bustos, Matilde; Sánchez-Mateos, Paloma; Corbí, Angel L

    2013-03-01

    Besides its role as a neurotransmitter, serotonin (5-hydroxytryptamine, 5HT) regulates inflammation and tissue repair via a set of receptors (5HT(1-7)) whose pattern of expression varies among cell lineages. Considering the importance of macrophage polarization plasticity for inflammatory responses and tissue repair, we evaluated whether 5HT modulates human macrophage polarization. 5HT inhibited the LPS-induced release of proinflammatory cytokines without affecting IL-10 production, upregulated the expression of M2 polarization-associated genes (SERPINB2, THBS1, STAB1, COL23A1), and reduced the expression of M1-associated genes (INHBA, CCR2, MMP12, SERPINE1, CD1B, ALDH1A2). Whereas only 5HT(7) mediated the inhibitory action of 5HT on the release of proinflammatory cytokines, both 5HT(2B) and 5HT(7) receptors mediated the pro-M2 skewing effect of 5HT. In fact, blockade of both receptors during in vitro monocyte-to-macrophage differentiation preferentially modulated the acquisition of M2 polarization markers. 5HT(2B) was found to be preferentially expressed by anti-inflammatory M2(M-CSF) macrophages and was detected in vivo in liver Kupffer cells and in tumor-associated macrophages. Therefore, 5HT modulates macrophage polarization and contributes to the maintenance of an anti-inflammatory state via 5HT(2B) and 5HT(7), whose identification as functionally relevant markers for anti-inflammatory/homeostatic human M2 macrophages suggests their potential therapeutic value in inflammatory pathologies. PMID:23355731

  10. Androgen receptor blockade using flutamide skewed sex ratio of litters in mice.

    PubMed

    Gharagozlou, Faramarz; Youssefi, Reza; Vojgani, Mehdi; Akbarinejad, Vahid; Rafiee, Ghazaleh

    2016-01-01

    Maternal testosterone has been indicated to affect sex ratio of offspring. The present study was conducted to elucidate the role of androgen receptor in this regard by blockade of androgen receptor using flutamide in female mice. Mice were randomly assigned to two experimental groups. Mice in the control (n = 20) and treatment (n = 20) groups received 8 IU equine chorionic gonadotropin (eCG) followed by human chorionic gonadotropin (hCG) injection (8 IU) 47 hr later. In addition, mice in the control and treatment groups received four injections of ethanol-saline vehicle and flutamide solution (2.50 mg), respectively, started from 1 hr before eCG injection until hCG injection at 12-hr intervals. Conception rate was not different between the treatment (18/20: 90.00%) and control (19/20: 95.00%) groups (p > 0.05). Litter size was higher in the treatment (8.22 ± 0.26) than control (7.21 ± 0.28) group (p < 0.05). Male sex ratio was lower in the flutamide-treated mice (67/148: 45.30%) as compared with the untreated ones (80/137: 58.40%; odds ratio = 1.69; p < 0.05). In conclusion, the results showed that androgen receptor blockade could skew sex ratio of offspring toward females implying that the effect of testosterone on sex ratio might be through binding to androgen receptor. In addition, the blockade of androgen receptor using flutamide appeared to enhance litter size. PMID:27482363

  11. Intergenerational and sibling conflict under patrilocality. A model of reproductive skew applied to human kinship.

    PubMed

    Ji, Ting; Xu, Jing-Jing; Mace, Ruth

    2014-03-01

    Here we argue that models developed to examine cooperation and conflict in communal breeders, using a "tug-of-war" model of reproductive skew generated by incomplete control, are an appropriate way to model human kinship systems. We apply such models to understand the patterns of effort put into competition between father and son and between brothers in conflict over family resources in a patrilineal kinship system. Co-resident kin do not necessarily emerge with equal shares of the cake in terms of reproductive output. The models show that, depending on the efficiency with which they can gain more control of the resource, on the marriage system, and on the relatedness of the partners in conflict, individuals can do better to help their relatives breed rather than fight each other for the resources needed to reproduce. The models show that when a son's father is still breeding with his mother, sons should not compete for any share of reproduction. However, under polygyny, increased effort is spent on father/son and brother/brother conflict. Fathers will win the majority of reproduction if dominant to sons (in contrast to the finding that daughters-in-law win in conflict over mothers-in-law in patrilocal kinship systems, which has been suggested as explaining the evolution of menopause). Hence who wins in the sharing of reproduction depends not just on which sex disperses but also on the relative competitive ability of all individuals to exploit family resources. Anthropologists have long argued that cultural norms can reduce conflict. These formal evolutionary models help us to quantify the effects of reproductive conflict in families, throwing light on the evolutionary basis not just of patterns of reproductive scheduling, but also human kinship and marriage systems.

  12. Androgen receptor blockade using flutamide skewed sex ratio of litters in mice

    PubMed Central

    Gharagozlou, Faramarz; Youssefi, Reza; Vojgani, Mehdi; Akbarinejad, Vahid; Rafiee, Ghazaleh

    2016-01-01

    Maternal testosterone has been indicated to affect sex ratio of offspring. The present study was conducted to elucidate the role of androgen receptor in this regard by blockade of androgen receptor using flutamide in female mice. Mice were randomly assigned to two experimental groups. Mice in the control (n = 20) and treatment (n = 20) groups received 8 IU equine chorionic gonadotropin (eCG) followed by human chorionic gonadotropin (hCG) injection (8 IU) 47 hr later. In addition, mice in the control and treatment groups received four injections of ethanol-saline vehicle and flutamide solution (2.50 mg), respectively, started from 1 hr before eCG injection until hCG injection at 12-hr intervals. Conception rate was not different between the treatment (18/20: 90.00%) and control (19/20: 95.00%) groups (p > 0.05). Litter size was higher in the treatment (8.22 ± 0.26) than control (7.21 ± 0.28) group (p < 0.05). Male sex ratio was lower in the flutamide-treated mice (67/148: 45.30%) as compared with the untreated ones (80/137: 58.40%; odds ratio = 1.69; p < 0.05). In conclusion, the results showed that androgen receptor blockade could skew sex ratio of offspring toward females implying that the effect of testosterone on sex ratio might be through binding to androgen receptor. In addition, the blockade of androgen receptor using flutamide appeared to enhance litter size. PMID:27482363

  13. Tumors skew endothelial cells to disrupt NK cell, T-cell and macrophage functions

    PubMed Central

    Mulligan, Jennifer K.; Lathers, Deanne M. R.

    2012-01-01

    Introduction Patients and mice with solid tumors, such as Lewis lung carcinoma (LLC), have defects in functions of immune effector cells. Endothelial cells, a component of the tumor vasculature, are potential regulators of immune cell functions. Therefore, these studies examined the impact of exposure to LLC tumor on the ability of endothelial cells to modulate immune cell functions. Materials and methods Endothelial cells were pre-treated with LLC tumor-conditioned medium (EndoT-sup) for 24 h. Control endothelial cells that were exposed to medium (EndoMedia) or epithelial cell-conditioned medium (EndoEpi-sup). After the initial 24 h incubation, endothelial cells were washed and fresh media was added. Cells were allowed to incubate for an additional 24 h. Supernatants from EndoMedia, EndoEpi-sup or EndoT-sup were collected and assayed for immune modulatory products and for immune modulatory activity. Results Supernatant from EndoT-sup contained increased levels of PGE2, IL-6 and VEGF as compared to EndoMedia and EndoEpi-sup controls. NK cell activity, as measured by TNF-α and IFN-γ secretion, was increased following exposure to media conditioned by EndoMedia and EndoEpi-sup. Exposure of NK cells to supernatants of EndoT-sup, also increases TNF-α and IFN-γ secretion, but to a lesser extent than by EndoMedia and EndoEpi-sup. Examination of macrophage functions demonstrated that supernatant from EndoT-sup decreased microbead phagocytosis and increased production of the immune suppressive mediators, IL-10 and PGE2. Lastly, T-cell responses to stimulation with anti-CD3 in the presence of supernatants from EndoT-sup were examined. IFN-γ production by CD8+ T-cells was reduced after exposure to EndoT-sup-conditioned medium, as compared to cells treatments with medium or control conditioned medium. Production of IFN-γ by CD4+ T-cells exposed to EndoT-sup was not altered. Conclusions Taken together, these studies demonstrate that tumors skew endothelial cells to

  14. Jointly Modeling Event Time and Skewed-Longitudinal Data with Missing Response and Mismeasured Covariate for AIDS Studies.

    PubMed

    Huang, Yangxin; Yan, Chunning; Xing, Dongyuan; Zhang, Nanhua; Chen, Henian

    2015-01-01

    In longitudinal studies it is often of interest to investigate how a repeatedly measured marker in time is associated with a time to an event of interest. This type of research question has given rise to a rapidly developing field of biostatistics research that deals with the joint modeling of longitudinal and time-to-event data. Normality of model errors in longitudinal model is a routine assumption, but it may be unrealistically obscuring important features of subject variations. Covariates are usually introduced in the models to partially explain between- and within-subject variations, but some covariates such as CD4 cell count may be often measured with substantial errors. Moreover, the responses may encounter nonignorable missing. Statistical analysis may be complicated dramatically based on longitudinal-survival joint models where longitudinal data with skewness, missing values, and measurement errors are observed. In this article, we relax the distributional assumptions for the longitudinal models using skewed (parametric) distribution and unspecified (nonparametric) distribution placed by a Dirichlet process prior, and address the simultaneous influence of skewness, missingness, covariate measurement error, and time-to-event process by jointly modeling three components (response process with missing values, covariate process with measurement errors, and time-to-event process) linked through the random-effects that characterize the underlying individual-specific longitudinal processes in Bayesian analysis. The method is illustrated with an AIDS study by jointly modeling HIV/CD4 dynamics and time to viral rebound in comparison with potential models with various scenarios and different distributional specifications. PMID:24905593

  15. Biased morph ratios and skewed mating success contribute to loss of genetic diversity in the distylous Pulmonaria officinalis

    PubMed Central

    Meeus, Sofie; Honnay, Olivier; Brys, Rein; Jacquemyn, Hans

    2012-01-01

    Background and Aims In heterostylous plant species, skewed morph ratios are not uncommon and may arise from a range of factors. Despite the recognized importance of skewed morph ratios on overall reproductive success within populations, little is known about the impact of skewed morph ratios on population genetic diversity and differentiation in heterostylous species. This study specifically aimed to clarify the effect of population size and morph bias on population genetic diversity and differentiation in the temperate forest herb Pulmonaria officinalis. This species is characterized by a distylous breeding system and shows morph-specific differences in reproductive success. Methods Genetic diversity was determined for 27 P. officinalis populations in northern Belgium by using eight recently developed microsatellite markers. Multiple regressions were used to assess the relationship between genetic diversity, morph bias and population size, and FST-values were calculated for short- and long-styled morphs separately to study genetic differentiation as a function of morph type. Key Results For all genetic measures used, morph bias was more important in explaining patterns of genetic diversity than population size, and in all cases patterns of population genetic diversity followed a quadratic function, which showed a symmetrical decrease in genetic diversity with increasing morph bias. However, probably due to the reproductive advantage of L-morphs relative to S-morphs, maximum genetic diversity was found in populations showing an excess of L-morphs (60·7 % L-morph). On the other hand, no significant difference in pairwise genetic distances between populations was observed between L- (0·107) and S-morphs (0·106). Conclusions Our results indicate that significant deviations from equal morph ratios not only affect plant reproductive success but also population genetic diversity of heterostylous plant species. Hence, when defining conservation measures for populations

  16. The origin of the skewed amplitude distribution of spontaneous excitatory junction potentials in poorly coupled smooth muscle cells

    PubMed Central

    Young, J.S.; Brain, K.L.; Cunnane, T.C.

    2007-01-01

    The skewed amplitude distribution of spontaneous excitatory junction potentials (sEJPs) in the mouse vas deferens and other electrically-coupled smooth muscle syncytia has been attributed to electrically-attenuated depolarizations resulting from the spontaneous release of quantized packets of ATP acting on remote smooth muscle cells (SMCs). However, in the present investigation surface SMCs of the mouse isolated vas deferens were poorly electrically coupled, with input resistances (176±18 MΩ, range: 141–221 MΩ, n=4) similar to those of dissociated cells. Furthermore, the amplitude of evoked EJPs was more variable in surface compared with deeper SMCs (F test, F=17.4, P<0.0001). Using simultaneous electrophysiology and confocal microscopy to investigate these poorly-coupled cells, it is shown that α-latrotoxin-stimulated sEJPs correlate, in timing (median delay ranged from −30 to −57 ms, P<0.05 in all experiments, n=5) and amplitude (Pearson product moment correlation, ρ>0.55 and P<0.001), with purinergic neuroeffector Ca2+ transients (NCTs) in SMCs. The temporal correlation between sEJPs of widely ranging amplitude with NCTs in the impaled SMC demonstrates that all sEJPs could arise from neurotransmitter action on the impaled cell and that the skewed distribution of sEJPs can be explained by the variable effect of packets of ATP on a single SMC. The amplitude correlation of sEJPs and NCTs argues against the attenuation of electrical signal amplitude along the length of a single SMC. The skewed sEJP amplitude distribution arising from neurotransmitter release on single SMCs is consistent with a broad neurotransmitter packet size distribution at sympathetic neuroeffector junctions. PMID:17208381

  17. Regional skew for California, and flood frequency for selected sites in the Sacramento-San Joaquin River Basin, based on data through water year 2006

    USGS Publications Warehouse

    Parrett, Charles; Veilleux, Andrea; Stedinger, J.R.; Barth, N.A.; Knifong, Donna L.; Ferris, J.C.

    2011-01-01

    Improved flood-frequency information is important throughout California in general and in the Sacramento-San Joaquin River Basin in particular, because of an extensive network of flood-control levees and the risk of catastrophic flooding. A key first step in updating flood-frequency information is determining regional skew. A Bayesian generalized least squares (GLS) regression method was used to derive a regional-skew model based on annual peak-discharge data for 158 long-term (30 or more years of record) stations throughout most of California. The desert areas in southeastern California had too few long-term stations to reliably determine regional skew for that hydrologically distinct region; therefore, the desert areas were excluded from the regional skew analysis for California. Of the 158 long-term stations used to determine regional skew, 145 have minimally regulated annual-peak discharges, and 13 stations are dam sites for which unregulated peak discharges were estimated from unregulated daily maximum discharge data furnished by the U.S. Army Corp of Engineers. Station skew was determined by using an expected moments algorithm (EMA) program for fitting the Pearson Type 3 flood-frequency distribution to the logarithms of annual peak-discharge data. The Bayesian GLS regression method previously developed was modified because of the large cross correlations among concurrent recorded peak discharges in California and the use of censored data and historical flood information with the new expected moments algorithm. In particular, to properly account for these cross-correlation problems and develop a suitable regression model and regression diagnostics, a combination of Bayesian weighted least squares and generalized least squares regression was adopted. This new methodology identified a nonlinear function relating regional skew to mean basin elevation. The regional skew values ranged from -0.62 for a mean basin elevation of zero to 0.61 for a mean basin elevation

  18. A robust approach for skewed and heavy-tailed outcomes in the analysis of health care expenditures.

    PubMed

    Cantoni, Eva; Ronchetti, Elvezio

    2006-03-01

    In this paper robust statistical procedures are presented for the analysis of skewed and heavy-tailed outcomes as they typically occur in health care data. The new estimators and test statistics are extensions of classical maximum likelihood techniques for generalized linear models. In contrast to their classical counterparts, the new robust techniques show lower variability and excellent efficiency properties in the presence of small deviations from the assumed model, i.e. when the underlying distribution of the data lies in a neighborhood of the model. A simulation study, an analysis on real data, and a sensitivity analysis confirm the good theoretical statistical properties of the new techniques.

  19. Irreversible simulated tempering algorithm with skew detailed balance conditions: a learning method of weight factors in simulated tempering

    NASA Astrophysics Data System (ADS)

    Sakai, Yuji; Hukushima, Koji

    2016-09-01

    Recent numerical studies concerning simulated tempering algorithm without the detailed balance condition are reviewed and an irreversible simulated tempering algorithm based on the skew detailed balance condition is described. A method to estimate weight factors in simulated tempering by sequentially implementing the irreversible simulated tempering algorithm is studied in comparison with the conventional simulated tempering algorithm satisfying the detailed balance condition. It is found that the total amount of Monte Carlo steps for estimating the weight factors is successfully reduced by applying the proposed method to an two-dimensional ferromagnetic Ising model.

  20. Grid generation in three dimensions by Poisson equations with control of cell size and skewness at boundary surfaces

    NASA Technical Reports Server (NTRS)

    Sorenson, R. L.; Steger, J. L.

    1983-01-01

    An algorithm for generating computational grids about arbitrary three-dimensional bodies is developed. The elliptic partial differential equation (PDE) approach developed by Steger and Sorenson and used in the NASA computer program GRAPE is extended from two to three dimensions. Forcing functions which are found automatically by the algorithm give the user the ability to control mesh cell size and skewness at boundary surfaces. This algorithm, as is typical of PDE grid generators, gives smooth grid lines and spacing in the interior of the grid. The method is applied to a rectilinear wind-tunnel case and to two body shapes in spherical coordinates.

  1. Development of regional skews for selected flood durations for the Central Valley Region, California, based on data through water year 2008

    USGS Publications Warehouse

    Lamontagne, Jonathan R.; Stedinger, Jery R.; Berenbrock, Charles; Veilleux, Andrea G.; Ferris, Justin C.; Knifong, Donna L.

    2012-01-01

    Flood-frequency information is important in the Central Valley region of California because of the high risk of catastrophic flooding. Most traditional flood-frequency studies focus on peak flows, but for the assessment of the adequacy of reservoirs, levees, other flood control structures, sustained flood flow (flood duration) frequency data are needed. This study focuses on rainfall or rain-on-snow floods, rather than the annual maximum, because rain events produce the largest floods in the region. A key to estimating flood-duration frequency is determining the regional skew for such data. Of the 50 sites used in this study to determine regional skew, 28 sites were considered to have little to no significant regulated flows, and for the 22 sites considered significantly regulated, unregulated daily flow data were synthesized by using reservoir storage changes and diversion records. The unregulated, annual maximum rainfall flood flows for selected durations (1-day, 3-day, 7-day, 15-day, and 30-day) for all 50 sites were furnished by the U.S. Army Corps of Engineers. Station skew was determined by using the expected moments algorithm program for fitting the Pearson Type 3 flood-frequency distribution to the logarithms of annual flood-duration data. Bayesian generalized least squares regression procedures used in earlier studies were modified to address problems caused by large cross correlations among concurrent rainfall floods in California and to address the extensive censoring of low outliers at some sites, by using the new expected moments algorithm for fitting the LP3 distribution to rainfall flood-duration data. To properly account for these problems and to develop suitable regional-skew regression models and regression diagnostics, a combination of ordinary least squares, weighted least squares, and Bayesian generalized least squares regressions were adopted. This new methodology determined that a nonlinear model relating regional skew to mean basin elevation

  2. High rates of pregnancy loss by subordinates leads to high reproductive skew in wild golden lion tamarins (Leontopithecus rosalia)

    PubMed Central

    Henry, MaLinda D.; Hankerson, Sarah J.; Siani, Jennifer M.; French, Jeffrey A.; Dietz, James M.

    2013-01-01

    Across taxa, cooperative breeding has been associated with high reproductive skew. Cooperatively breeding golden lion tamarins (Leontopithecus rosalia) were long thought to have a monogynous mating system in which reproduction was limited to a single dominant female. Subordinates with few reproductive opportunities delayed dispersal and remained in the natal group to provide alloparental care to siblings, thus allowing dominant reproductive females to meet the energetic needs associated with high rates of reproduction and successful infant rearing. The goal of this study was to re-assess monogyny in wild golden lion tamarin groups based upon pregnancy diagnoses that used non-invasive enzyme immunoassay for progesterone and cortisol, combined with weekly data on individual weight gain, bi-annual physical examinations noting pregnancy and lactation status and daily behavioral observations. We established quantitative and qualitative criteria to detect and determine the timing of pregnancies that did not result in the birth of infants. Pregnancy polygyny occurred in 83% of golden lion tamarin groups studied. The loss of 64% of subordinate pregnancies compared to only 15% by dominant females limited reproductive success mainly to dominant females, thus maintaining high reproductive skew in female golden lion tamarins. Pregnancy loss by subordinate adults did not appear to result from dominant interference in subordinate hormonal mechanisms, but more likely resulted from subordinate abandonment of newborn infants to mitigate dominant aggression. PMID:23454002

  3. Quantitative Method for the Optimal Subtraction of Continuum Emission from Narrow-band Images: Skewness Transition Analysis

    NASA Astrophysics Data System (ADS)

    Hong, Sungryong; Calzetti, Daniela; Dickinson, Mark

    2014-01-01

    We present an objective method to remove the stellar continuum emission from narrow-band images to derive emission-line images. The method is based on the skewness of the pixel histogram of the residual images. Specifically, we exploit a transition in the skewness of the signal in the continuum-subtracted image, which appears when the image changes from being undersubtracted to oversubtracted. Tests on one-dimensional artificial images demonstrate that the transition identifies the optimal scaling factor μ to be used on the broad-band image IB in order to produce the optimal line-emission image IE, i.e., IE = IN-μIB, with IN the original (unsubtracted) narrow-band image. The advantage of this method is that it uses all information-bearing pixels in the final image, and not just a subset of those pixels (the latter being common in many traditional approaches to stellar continuum removal from narrow-band images). We apply our method to actual images, both from ground-based and space facilities, in particular to WFPC2 and ACS images from the Hubble Space Telescope, and we show that it is successful irrespective of the nature of the sources (point-like or extended). We also discuss the impact on the accuracy of the method of nonoptimal images, such as those containing saturated sources or nonuniform background, and present workarounds for those problems.

  4. A Bayesian mixture of semiparametric mixed-effects joint models for skewed-longitudinal and time-to-event data.

    PubMed

    Chen, Jiaqing; Huang, Yangxin

    2015-09-10

    In longitudinal studies, it is of interest to investigate how repeatedly measured markers in time are associated with a time to an event of interest, and in the mean time, the repeated measurements are often observed with the features of a heterogeneous population, non-normality, and covariate measured with error because of longitudinal nature. Statistical analysis may complicate dramatically when one analyzes longitudinal-survival data with these features together. Recently, a mixture of skewed distributions has received increasing attention in the treatment of heterogeneous data involving asymmetric behaviors across subclasses, but there are relatively few studies accommodating heterogeneity, non-normality, and measurement error in covariate simultaneously arose in longitudinal-survival data setting. Under the umbrella of Bayesian inference, this article explores a finite mixture of semiparametric mixed-effects joint models with skewed distributions for longitudinal measures with an attempt to mediate homogeneous characteristics, adjust departures from normality, and tailor accuracy from measurement error in covariate as well as overcome shortages of confidence in specifying a time-to-event model. The Bayesian mixture of joint modeling offers an appropriate avenue to estimate not only all parameters of mixture joint models but also probabilities of class membership. Simulation studies are conducted to assess the performance of the proposed method, and a real example is analyzed to demonstrate the methodology. The results are reported by comparing potential models with various scenarios.

  5. An 8-bit 100-MS/s digital-to-skew converter embedded switch with a 200-ps range for time-interleaved sampling

    NASA Astrophysics Data System (ADS)

    Xiaoshi, Zhu; Chixiao, Chen; Jialiang, Xu; Fan, Ye; Junyan, Ren

    2013-03-01

    A sampling switch with an embedded digital-to-skew converter (DSC) is presented. The proposed switch eliminates time-interleaved ADCs' skews by adjusting the boosted voltage. A similar bridged capacitors' charge sharing structure is used to minimize the area. The circuit is fabricated in a 0.18 μm CMOS process and achieves sub-1 ps resolution and 200 ps timing range at a rate of 100 MS/s. The power consumption is 430 μW at maximum. The measurement result also includes a 2-channel 14-bit 100 MS/s time-interleaved ADCs (TI-ADCs) with the proposed DSC switch's demonstration. This scheme is widely applicable for the clock skew and aperture error calibration demanded in TI-ADCs and SHA-less ADCs.

  6. Estimating the mean and standard deviation of environmental data with below detection limit observations: Considering highly skewed data and model misspecification.

    PubMed

    Shoari, Niloofar; Dubé, Jean-Sébastien; Chenouri, Shoja'eddin

    2015-11-01

    In environmental studies, concentration measurements frequently fall below detection limits of measuring instruments, resulting in left-censored data. Some studies employ parametric methods such as the maximum likelihood estimator (MLE), robust regression on order statistic (rROS), and gamma regression on order statistic (GROS), while others suggest a non-parametric approach, the Kaplan-Meier method (KM). Using examples of real data from a soil characterization study in Montreal, we highlight the need for additional investigations that aim at unifying the existing literature. A number of studies have examined this issue; however, those considering data skewness and model misspecification are rare. These aspects are investigated in this paper through simulations. Among other findings, results show that for low skewed data, the performance of different statistical methods is comparable, regardless of the censoring percentage and sample size. For highly skewed data, the performance of the MLE method under lognormal and Weibull distributions is questionable; particularly, when the sample size is small or censoring percentage is high. In such conditions, MLE under gamma distribution, rROS, GROS, and KM are less sensitive to skewness. Related to model misspecification, MLE based on lognormal and Weibull distributions provides poor estimates when the true distribution of data is misspecified. However, the methods of rROS, GROS, and MLE under gamma distribution are generally robust to model misspecifications regardless of skewness, sample size, and censoring percentage. Since the characteristics of environmental data (e.g., type of distribution and skewness) are unknown a priori, we suggest using MLE based on gamma distribution, rROS and GROS.

  7. A decomposition theorem for the space of C{sup 1}-smooth skew products with complicated dynamics of the quotient map

    SciTech Connect

    Efremova, L S

    2013-11-30

    We use the notions of the Ω-function and functions suitable to it, to give a detailed proof of a decomposition theorem for the space of C{sup 1}-smooth skew products of interval maps whose quotient maps have complicated dynamics and satisfy the additional condition of Ω-stability with respect to the C{sup 1}-norm. In our theorem, the space of C{sup 1}-smooth skew products is decomposed into a union of four nonempty, pairwise disjoint subspaces. We give examples of maps contained in each of the four subspaces. Bibliography: 46 titles.

  8. Influence of complex disorder on skew-scattering Hall effects in L 10 -ordered FePt alloy

    NASA Astrophysics Data System (ADS)

    Zimmermann, Bernd; Long, Nguyen H.; Mavropoulos, Phivos; Blügel, Stefan; Mokrousov, Yuriy

    2016-08-01

    We show by first-principles calculations that the skew-scattering anomalous Hall and spin Hall angles of L 10 -ordered FePt drastically depend on different types of disorder. A different sign of the anomalous Hall angle is obtained when slightly deviating from the stoichiometric ratio towards the Fe-rich side as compared to the Pt-rich side. For stoichiometric samples, short-range ordering of defects has a profound effect on the Hall angles and can change them by a factor of 2 as compared to the case of uncorrelated disorder. This might explain the vast range of anomalous Hall angles measured in experiments, which undergo different preparation procedures and thus might differ in their crystallographic quality.

  9. Study of Row Phase Dependent Skew Quadrupole Fields in Apple-II Type EPUs at the ALS

    SciTech Connect

    Steier, C.; Marks, S.; Prestemon, Soren; Robin, David; Schlueter, Ross; Wolski, Andrzej

    2004-05-07

    Since about 5 years, Apple-II type Elliptically Polarizing Undulators (EPU) have been used very successfully at the ALS to generate high brightness photon beams with arbitrary polarization. However, both EPUs installed so far cause significant changes of the vertical beamsize, especially when the row phase is changed to change the polarization of the photons emitted. Detailed measurements indicate this is caused by a row phase dependent skew quadrupole term in the EPUs. Magnetic measurements revealed the same effect for the third EPU to be installed later this year. All measurements to identify and quantify the effect with beam will be presented, as well as some results of magnetic bench measurements and numeric field simulations.

  10. Approximation of skewed interfaces with tensor-based model reduction procedures: Application to the reduced basis hierarchical model reduction approach

    NASA Astrophysics Data System (ADS)

    Ohlberger, Mario; Smetana, Kathrin

    2016-09-01

    In this article we introduce a procedure, which allows to recover the potentially very good approximation properties of tensor-based model reduction procedures for the solution of partial differential equations in the presence of interfaces or strong gradients in the solution which are skewed with respect to the coordinate axes. The two key ideas are the location of the interface either by solving a lower-dimensional partial differential equation or by using data functions and the subsequent removal of the interface of the solution by choosing the determined interface as the lifting function of the Dirichlet boundary conditions. We demonstrate in numerical experiments for linear elliptic equations and the reduced basis-hierarchical model reduction approach that the proposed procedure locates the interface well and yields a significantly improved convergence behavior even in the case when we only consider an approximation of the interface.

  11. Skewness, long-time memory, and non-stationarity: Application to leverage effect in financial time series

    NASA Astrophysics Data System (ADS)

    Roman, H. E.; Porto, M.; Dose, C.

    2008-10-01

    We analyze daily log-returns data for a set of 1200 stocks, taken from US stock markets, over a period of 2481 trading days (January 1996-November 2005). We estimate the degree of non-stationarity in daily market volatility employing a polynomial fit, used as a detrending function. We find that the autocorrelation function of absolute detrended log-returns departs strongly from the corresponding original data autocorrelation function, while the observed leverage effect depends only weakly on trends. Such effect is shown to occur when both skewness and long-time memory are simultaneously present. A fractional derivative random walk model is discussed yielding a quantitative agreement with the empirical results.

  12. White-Matter Tract Connecting Anterior Insula to Nucleus Accumbens Correlates with Reduced Preference for Positively Skewed Gambles

    PubMed Central

    Leong, Josiah K.; Pestilli, Franco; Wu, Charlene C.; Samanez-Larkin, Gregory R.; Knutson, Brian

    2016-01-01

    SUMMARY Individuals sometimes show inconsistent risk preferences, including excessive attraction to gambles featuring small chances of winning large amounts (called “positively skewed” gambles). While functional neuroimaging research indicates that nucleus accumbens (NAcc) and anterior insula (AIns) activity inversely predict risky choice, structural connections between these regions have not been described in humans. By combining diffusion-weighted MRI with tractography, we identified the anatomical trajectory of white-matter tracts projecting from the AIns to the NAcc and statistically validated these tracts using Linear Fascicle Evaluation (LiFE) and virtual lesions. Coherence of the right AIns-NAcc tract correlated with reduced preferences for positively skewed gambles. Further, diminished NAcc activity during gamble presentation mediated the association between tract structure and choice. These results identify an unreported tract connecting the AIns to the NAcc in humans and support the notion that structural connections can alter behavior by influencing brain activity as individuals weigh uncertain gains against uncertain losses. PMID:26748088

  13. It takes two to tango: reproductive skew and social correlates of male mating success in a lek-breeding bird.

    PubMed

    Ryder, Thomas B; Parker, Patricia G; Blake, John G; Loiselle, Bette A

    2009-07-01

    Variance in reproductive success among individuals is a defining characteristic of many social vertebrates. Yet, our understanding of which male attributes contribute to reproductive success is still fragmentary in most cases. Male-male reproductive coalitions, where males jointly display to attract females, are of particular interest to evolutionary biologists because one male appears to forego reproduction to assist the social partner. By examining the relationship between social behaviour and reproductive success, we can elucidate the proximate function of coalitions in the context of mate choice. Here, we use data from a 4-year study of wire-tailed manakins (Pipra filicauda) to provide molecular estimates of reproductive skew and to test the hypothesis that male-male social interactions, in the context of coordinated displays, positively influence a male's reproductive success. More specifically, we quantify male-male social interactions using network metrics and predict that greater connectivity will result in higher relative reproductive success. Our data show that four out of six leks studied had significant reproductive skew, with success apportioned to very few individuals in each lek. Metrics of male social affiliations derived from our network analysis, especially male connectivity, measured as the number of males with whom the focal male has extended interactions, were strong predictors of the number of offspring sired. Thus, network connectivity is associated with male fitness in wire-tailed manakins. This pattern may be the result of shared cues used by both sexes to assess male quality, or the result of strict female choice for coordinated display behaviour.

  14. Haemophilia A and cardiovascular morbidity in a female SHAM syndrome carrier due to skewed X chromosome inactivation.

    PubMed

    Janczar, Szymon; Kosinska, Joanna; Ploski, Rafal; Pastorczak, Agata; Wegner, Olga; Zalewska-Szewczyk, Beata; Paige, Adam J W; Borowiec, Maciej; Mlynarski, Wojciech

    2016-01-01

    We have recently described a severe haemophilia A and moyamoya (SHAM) syndrome caused by Xq28 deletions encompassing F8 and the BRCC3 familial moyamoya gene. The phenotype includes haemophilia A, moyamoya angiopathy, dysmorphia and hypertension. The genetic analysis of the family of our SHAM patient demonstrated carrier state in proband's mother and sister. The patient's mother is apparently well, whereas his currently 18-years-old sister presents with mild haemophilia A, coarctation of the aorta, hypertension, and ventricular arrhythmia. We performed X chromosome inactivation assay based on HpaII methylation analysis of a polymorphic short tandem repeat (STR) in the X linked AR (androgen receptor) gene and used quantitative real-time RT PCR to measure the expression of genes from the deleted region in proband's family members. We found an extremely skewed X chromosome inactivation pattern in the female members of the family leading to preferential inactivation of the X chromosome without Xq28 deletion in patient's sister. We demonstrated differential expression of the genes from the deleted region in four members of the family, that tightly correlates with the clinical features. In conclusion, we show that the haematologic and cardiovascular morbidity and the discrepancy between patient's sister and mother despite the same genetic lesion are due to skewed X chromosome inactivation leading to clinically relevant differential expression of SHAM syndrome genes. This report highlights the role for BRCC3 in cardiovascular physiology and disease, and demonstrates that in some complex hereditary syndromes full diagnostics may require the examination of both genetic and epigenetic events. PMID:26691666

  15. T helper cell 2 immune skewing in pregnancy/early life: chemical exposure and the development of atopic disease and allergy.

    PubMed

    McFadden, J P; Thyssen, J P; Basketter, D A; Puangpet, P; Kimber, I

    2015-03-01

    During the last 50 years there has been a significant increase in Western societies of atopic disease and associated allergy. The balance between functional subpopulations of T helper cells (Th) determines the quality of the immune response provoked by antigen. One such subpopulation - Th2 cells - is associated with the production of IgE antibody and atopic allergy, whereas, Th1 cells antagonize IgE responses and the development of allergic disease. In seeking to provide a mechanistic basis for this increased prevalence of allergic disease, one proposal has been the 'hygiene hypothesis', which argues that in Westernized societies reduced exposure during early childhood to pathogenic microorganisms favours the development of atopic allergy. Pregnancy is normally associated with Th2 skewing, which persists for some months in the neonate before Th1/Th2 realignment occurs. In this review, we consider the immunophysiology of Th2 immune skewing during pregnancy. In particular, we explore the possibility that altered and increased patterns of exposure to certain chemicals have served to accentuate this normal Th2 skewing and therefore further promote the persistence of a Th2 bias in neonates. Furthermore, we propose that the more marked Th2 skewing observed in first pregnancy may, at least in part, explain the higher prevalence of atopic disease and allergy in the first born. PMID:25354210

  16. Parentage analysis of Ansell's mole-rat family groups indicates a high reproductive skew despite relatively relaxed ecological constraints on dispersal.

    PubMed

    Patzenhauerová, Hana; Šklíba, Jan; Bryja, Josef; Šumbera, Radim

    2013-10-01

    To better understand evolutionary pathways leading to eusociality, interspecific comparisons are needed, which would use a common axis, such as that of reproductive skew, to array species. African mole-rats (Bathyergidae, Rodentia) provide an outstanding model of social evolution because of a wide range of social organizations within a single family; however, their reproductive skew is difficult to estimate, due to their cryptic lifestyle. A maximum skew could theoretically be reached in groups where reproduction is monopolized by a stable breeding pair, but the value could be decreased by breeding-male and breeding-female turnover, shared reproduction and extra-group mating. The frequency of such events should be higher in species or populations inhabiting mesic environments with relaxed ecological constraints on dispersal. To test this prediction, we studied patterns of parentage and relatedness within 16 groups of Ansell's mole-rat (Fukomys anselli) in mesic miombo woodland. Contrary to expectation, there was no shared reproduction (more than one breeder of a particular sex) within the studied groups, and proportion of immigrants and offspring not assigned to current breeding males was low. The within-group parentage and relatedness patterns observed resemble arid populations of 'eusocial' Fukomys damarensis, rather than a mesic population of 'social' Cryptomys hottentotus. As a possible explanation, we propose that the extent ecological conditions affect reproductive skew may be markedly affected by life history and natural history traits of the particular species and genera.

  17. The actin cytoskeleton is a suppressor of the endogenous skewing behaviour of Arabidopsis primary roots in microgravity.

    PubMed

    Nakashima, J; Liao, F; Sparks, J A; Tang, Y; Blancaflor, E B

    2014-01-01

    Before plants can be effectively utilised as a component of enclosed life-support systems for space exploration, it is important to understand the molecular mechanisms by which they develop in microgravity. Using the Biological Research in Canisters (BRIC) hardware on board the second to the last flight of the Space Shuttle Discovery (STS-131 mission), we studied how microgravity impacts root growth in Arabidopsis thaliana. Ground-based studies showed that the actin cytoskeleton negatively regulates root gravity responses on Earth, leading us to hypothesise that actin might also be an important modulator of root growth behaviour in space. We investigated how microgravity impacted root growth of wild type (ecotype Columbia) and a mutant (act2-3) disrupted in a root-expressed vegetative actin isoform (ACTIN2). Roots of etiolated wild-type and act2-3 seedlings grown in space skewed vigorously toward the left, which was unexpected given the reduced directional cue provided by gravity. The left-handed directional root growth in space was more pronounced in act2-3 mutants than wild type. To quantify differences in root orientation of these two genotypes in space, we developed an algorithm where single root images were converted into binary images using computational edge detection methods. Binary images were processed with Fast Fourier Transformation (FFT), and histogram and entropy were used to determine spectral distribution, such that high entropy values corresponded to roots that deviated more strongly from linear orientation whereas low entropy values represented straight roots. We found that act2-3 roots had a statistically stronger skewing/coiling response than wild-type roots, but such differences were not apparent on Earth. Ultrastructural studies revealed that newly developed cell walls of space-grown act2-3 roots were more severely disrupted compared to space-grown wild type, and ground control wild-type and act2-3 roots. Collectively, our results provide

  18. The actin cytoskeleton is a suppressor of the endogenous skewing behaviour of Arabidopsis primary roots in microgravity.

    PubMed

    Nakashima, J; Liao, F; Sparks, J A; Tang, Y; Blancaflor, E B

    2014-01-01

    Before plants can be effectively utilised as a component of enclosed life-support systems for space exploration, it is important to understand the molecular mechanisms by which they develop in microgravity. Using the Biological Research in Canisters (BRIC) hardware on board the second to the last flight of the Space Shuttle Discovery (STS-131 mission), we studied how microgravity impacts root growth in Arabidopsis thaliana. Ground-based studies showed that the actin cytoskeleton negatively regulates root gravity responses on Earth, leading us to hypothesise that actin might also be an important modulator of root growth behaviour in space. We investigated how microgravity impacted root growth of wild type (ecotype Columbia) and a mutant (act2-3) disrupted in a root-expressed vegetative actin isoform (ACTIN2). Roots of etiolated wild-type and act2-3 seedlings grown in space skewed vigorously toward the left, which was unexpected given the reduced directional cue provided by gravity. The left-handed directional root growth in space was more pronounced in act2-3 mutants than wild type. To quantify differences in root orientation of these two genotypes in space, we developed an algorithm where single root images were converted into binary images using computational edge detection methods. Binary images were processed with Fast Fourier Transformation (FFT), and histogram and entropy were used to determine spectral distribution, such that high entropy values corresponded to roots that deviated more strongly from linear orientation whereas low entropy values represented straight roots. We found that act2-3 roots had a statistically stronger skewing/coiling response than wild-type roots, but such differences were not apparent on Earth. Ultrastructural studies revealed that newly developed cell walls of space-grown act2-3 roots were more severely disrupted compared to space-grown wild type, and ground control wild-type and act2-3 roots. Collectively, our results provide

  19. Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact on Clinical Outcome

    PubMed Central

    Toia, Francesca; Buccheri, Simona; Anfosso, Ampelio; Moschella, Francesco; Dieli, Francesco; Meraviglia, Serena; Cordova, Adriana

    2016-01-01

    Objective The aim of this study was to evaluate over time circulating γδ T lymphocytes in melanoma patients in terms of frequency, effector functions, and relationship with clinical stage and evolution, by comparing preoperative values to those obtained at a mean follow-up of 36 months or in the event of recurrence or disease progression, and to those of healthy controls. Also, we correlated the presence of tumor-infiltrating γδ T lymphocytes with clinical evolution of melanoma. Results Mean frequencies of circulating γδ T cells before and after melanoma removal were very similar and comparable to healthy subjects, but patients who progressed to stage III or IV showed a significantly decreased frequency of circulating Vγ9Vδ2 T cells. The distribution of Vγ9Vδ2 memory and effector subsets was similar in healthy subjects and melanoma patients at diagnosis, but circulating γδ T cells of patients after melanoma removal had a skewed terminally-differentiated effector memory phenotype. Highly suggestive of progressive differentiation toward a cytotoxic phenotype, Vγ9Vδ2T cells from patients at follow up had increased cytotoxic potential and limited cytokine production capability, while the opposite pattern was detected in Vγ9Vδ2T cells from patients before melanoma removal. Conclusions Follow-up data also showed that tumor infiltrating γδ T cells were significantly associated with lower mortality and relapse rates, suggesting that they may serve as a prognostic biomarker, for human melanoma. PMID:26915072

  20. De novo interstitial direct duplication of Xq21.1q25 associated with skewed X-inactivation pattern.

    PubMed

    Tachdjian, G; Aboura, A; Benkhalifa, M; Creveaux, I; Foix-Hélias, L; Gadisseux, J F; Boespflug-Tanguy, O; Mohammed, M; Labrune, P

    2004-12-15

    Genotype-phenotype correlation in women with an abnormal phenotype associated with a duplication of the long arm of the X chromosome remains unclear. We report on prenatal diagnosis and follow-up of a girl with an Xq duplication and dysmorphic features. The abnormal phenotype included growth retardation, hypotonia, and nystagmus. In order to improve the resolution of the cytogenetic analysis, we used both conventional and array-based comparative genomic hybridization to perform a global molecular cytogenetic analysis of the genome. These molecular cytogenetic analyses showed a direct duplication Xq21.1 --> q25 without other chromosomal abnormalities. This duplication was originating from the paternal X chromosome. Moreover, a skewed X-inactivation pattern was observed leading to a partial functional disomy of the chromosomal region Xq21.1q25. This report and review of the literature suggest that functional disomy for chromosome X could explain the abnormal phenotype. In prenatal diagnosis, this can have implication for patient management and genetic counseling.

  1. Next Generation Sequencing Reveals Skewing of the T and B Cell Receptor Repertoires in Patients with Wiskott–Aldrich Syndrome

    PubMed Central

    O’Connell, Amy E.; Volpi, Stefano; Dobbs, Kerry; Fiorini, Claudia; Tsitsikov, Erdyni; de Boer, Helen; Barlan, Isil B.; Despotovic, Jenny M.; Espinosa-Rosales, Francisco J.; Hanson, I. Celine; Kanariou, Maria G.; Martínez-Beckerat, Roxana; Mayorga-Sirera, Alvaro; Mejia-Carvajal, Carmen; Radwan, Nesrine; Weiss, Aaron R.; Pai, Sung-Yun; Lee, Yu Nee; Notarangelo, Luigi D.

    2014-01-01

    The Wiskott–Aldrich syndrome (WAS) is due to mutations of the WAS gene encoding for the cytoskeletal WAS protein, leading to abnormal downstream signaling from the T cell and B cell antigen receptors (TCR and BCR). We hypothesized that the impaired signaling through the TCR and BCR in WAS would subsequently lead to aberrations in the immune repertoire of WAS patients. Using next generation sequencing (NGS), the T cell receptor β and B cell immunoglobulin heavy chain (IGH) repertoires of eight patients with WAS and six controls were sequenced. Clonal expansions were identified within memory CD4+ cells as well as in total, naïve and memory CD8+ cells from WAS patients. In the B cell compartment, WAS patient IGH repertoires were also clonally expanded and showed skewed usage of IGHV and IGHJ genes, and increased usage of IGHG constant genes, compared with controls. To our knowledge, this is the first study that demonstrates significant abnormalities of the immune repertoire in WAS patients using NGS. PMID:25101082

  2. Airway epithelial cell-derived insulin-like growth factor-1 triggers skewed CD8(+) T cell polarization.

    PubMed

    Zou, Jian-Yong; Huang, Shao-hong; Li, Yun; Chen, Hui-guo; Rong, Jian; Ye, Sheng

    2014-10-01

    Skewed CD8(+) T cell responses are important in airway inflammation. This study investigates the role of the airway epithelial cell-derived insulin-like growth factor 1 (IGF1) in contributing to CD8(+) T cell polarization. Expression of IGF1 in the airway epithelial cell line, RPMI2650 cells, was assessed by quantitative real time RT-PCR and Western blotting. The role of IGF1 in regulating CD8(+) T cell activation was observed by coculture of mite allergen-primed RPMI2650 cells and naïve CD8(+) T cells. CD8(+) T cell polarization was assessed by the carboxyfluorescein succinimidyl ester-dilution assay and the determination of cytotoxic cytokine levels in the culture medium. Exposure to mite allergen, Der p1, increased the expression of IGF1 by RPMI2650 cells. The epithelial cell-derived IGF1 prevented the activation-induced cell death by inducing the p53 gene hypermethylation. Mite allergen-primed RPMI2650 cells induced an antigen-specific CD8(+) T cell polarization. We conclude that mite allergens induce airway epithelial cell line, RPMI2650 cells, to produce IGF1; the latter contributes to antigen-specific CD8(+) T cell polarization. PMID:24844927

  3. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

    PubMed Central

    Tinti, Michele; Dissanayake, Kumara; Synowsky, Silvia; Albergante, Luca; MacKintosh, Carol

    2014-01-01

    The complexity of signalling pathways was boosted at the origin of the vertebrates, when two rounds of whole genome duplication (2R-WGD) occurred. Those genes and proteins that have survived from the 2R-WGD—termed 2R-ohnologues—belong to families of two to four members, and are enriched in signalling components relevant to cancer. Here, we find that while only approximately 30% of human transcript-coding genes are 2R-ohnologues, they carry 42–60% of the gene mutations in 30 different cancer types. Across a subset of cancer datasets, including melanoma, breast, lung adenocarcinoma, liver and medulloblastoma, we identified 673 2R-ohnologue families in which one gene carries mutations at multiple positions, while sister genes in the same family are relatively mutation free. Strikingly, in 315 of the 322 2R-ohnologue families displaying such a skew in multiple cancers, the same gene carries the heaviest mutation load in each cancer, and usually the second-ranked gene is also the same in each cancer. Our findings inspire the hypothesis that in certain cancers, heterogeneous combinations of genetic changes impair parts of the 2R-WGD signalling networks and force information flow through a limited set of oncogenic pathways in which specific non-mutated 2R-ohnologues serve as effectors. The non-mutated 2R-ohnologues are therefore potential therapeutic targets. These include proteins linked to growth factor signalling, neurotransmission and ion channels. PMID:24806839

  4. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers.

    PubMed

    Tinti, Michele; Dissanayake, Kumara; Synowsky, Silvia; Albergante, Luca; MacKintosh, Carol

    2014-05-01

    The complexity of signalling pathways was boosted at the origin of the vertebrates, when two rounds of whole genome duplication (2R-WGD) occurred. Those genes and proteins that have survived from the 2R-WGD—termed 2R-ohnologues—belong to families of two to four members, and are enriched in signalling components relevant to cancer. Here, we find that while only approximately 30% of human transcript-coding genes are 2R-ohnologues, they carry 42–60% of the gene mutations in 30 different cancer types. Across a subset of cancer datasets, including melanoma, breast, lung adenocarcinoma, liver and medulloblastoma, we identified 673 2R-ohnologue families in which one gene carries mutations at multiple positions, while sister genes in the same family are relatively mutation free. Strikingly, in 315 of the 322 2R-ohnologue families displaying such a skew in multiple cancers, the same gene carries the heaviest mutation load in each cancer, and usually the second-ranked gene is also the same in each cancer. Our findings inspire the hypothesis that in certain cancers, heterogeneous combinations of genetic changes impair parts of the 2R-WGD signalling networks and force information flow through a limited set of oncogenic pathways in which specific non-mutated 2R-ohnologues serve as effectors. The non-mutated 2R-ohnologues are therefore potential therapeutic targets. These include proteins linked to growth factor signalling, neurotransmission and ion channels.

  5. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers.

    PubMed

    Tinti, Michele; Dissanayake, Kumara; Synowsky, Silvia; Albergante, Luca; MacKintosh, Carol

    2014-01-01

    The complexity of signalling pathways was boosted at the origin of the vertebrates, when two rounds of whole genome duplication (2R-WGD) occurred. Those genes and proteins that have survived from the 2R-WGD-termed 2R-ohnologues-belong to families of two to four members, and are enriched in signalling components relevant to cancer. Here, we find that while only approximately 30% of human transcript-coding genes are 2R-ohnologues, they carry 42-60% of the gene mutations in 30 different cancer types. Across a subset of cancer datasets, including melanoma, breast, lung adenocarcinoma, liver and medulloblastoma, we identified 673 2R-ohnologue families in which one gene carries mutations at multiple positions, while sister genes in the same family are relatively mutation free. Strikingly, in 315 of the 322 2R-ohnologue families displaying such a skew in multiple cancers, the same gene carries the heaviest mutation load in each cancer, and usually the second-ranked gene is also the same in each cancer. Our findings inspire the hypothesis that in certain cancers, heterogeneous combinations of genetic changes impair parts of the 2R-WGD signalling networks and force information flow through a limited set of oncogenic pathways in which specific non-mutated 2R-ohnologues serve as effectors. The non-mutated 2R-ohnologues are therefore potential therapeutic targets. These include proteins linked to growth factor signalling, neurotransmission and ion channels.

  6. On the effect of intermittency of turbulence on the parabolic relation between skewness and kurtosis in magnetized plasmas

    SciTech Connect

    Guszejnov, Dávid; Lazányi, Nóra; Bencze, Attila; Zoletnik, Sándor

    2013-11-15

    This paper is aimed to contribute to the scientific discussions that have been triggered by the experimental observation of a quadratic relation between the kurtosis and skewness of turbulent fluctuations present in fusion plasmas and other nonlinear physical systems. In this paper, we offer a general statistical model which attributes the observed K=aS{sup 2}+b relation to the varying intermittency of the experimental signals. The model is a two random variable model constructed to catch the essential intermittent feature of the real signal. One of the variables is the amplitude of the underlying intermittent event (e.g., turbulent structure) while the other is connected to the intermittency level of the system. This simple model can attribute physical meaning to the a and b coefficients, as they characterize the spatio-temporal statistics of intermittent events. By constructing a particle-conserving Gaussian model for the underlying coherent structures, the experimentally measured a and b coefficients could be adequately reproduced.

  7. Effects of rotation on coolant passage heat transfer. Volume 2: Coolant passages with trips normal and skewed to the flow

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.

    1993-01-01

    An experimental program was conducted to investigate heat transfer and pressure loss characteristics of rotating multipass passages, for configurations and dimensions typical of modem turbine blades. This experimental program is one part of the NASA Hot Section Technology (HOST) Initiative, which has as its overall objective the development and verification of improved analysis methods that will form the basis for a design system that will produce turbine components with improved durability. The objective of this program was the generation of a data base of heat transfer and pressure loss data required to develop heat transfer correlations and to assess computational fluid dynamic techniques for rotating coolant passages. The experimental work was broken down into two phases. Phase 1 consists of experiments conducted in a smooth wall large scale heat transfer model. A detailed discussion of these results was presented in volume 1 of a NASA Report. In Phase 2 the large scale model was modified to investigate the effects of skewed and normal passage turbulators. The results of Phase 2 along with comparison to Phase 1 is the subject of this Volume 2 NASA Report.

  8. Discovery of the Red-Skewed K-alpha Iron Line in Cyg X-2 with Suzaku

    NASA Technical Reports Server (NTRS)

    Shaposhnikov, Nikolai; Titarchuk, Lev; Laurent, Philippe

    2008-01-01

    We report on the Suzaku observation of neutron star low-mass X-ray binary Cygnus X-2 which reveals strong iron K-alpha emission line. The line profile shows a prominent red wing extending down to 4 keV. This discovery increases the number of neutron star sources where red-skewed iron lines were observed and strongly suggests that this phenomenon is common not only in black holes but also in other types of compact objects. We examine the line profile by fitting it with the model which attributes its production to the relativistic effects due to disk reflection of X-ray radiation. We also apply an alternative model where the red wing is a result of down-scattering effect of the first order with respect to electron velocity in the wind outflow. Both models describe adequately the observed line profile. However, the X-ray variability in a state similar to that in the Suzaku observation which we establish by analysing RXTE observation favors the wind origin of the line formation.

  9. Simultaneous Bayesian Inference for Linear, Nonlinear and Semiparametric Mixed-Effects Models with Skew-Normality and Measurement Errors in Covariates

    PubMed Central

    Huang, Yangxin; Chen, Ren; Dagne, Getachew

    2011-01-01

    In recent years, various mixed-effects models have been suggested for estimating viral decay rates in HIV dynamic models for complex longitudinal data. Among those models are linear mixed-effects (LME), nonlinear mixed-effects (NLME), and semiparametric nonlinear mixed-effects (SNLME) models. However, a critical question is whether these models produce coherent estimates of viral decay rates, and if not, which model is appropriate and should be used in practice. In addition, one often assumes that a model random error is normally distributed, but the normality assumption may be unrealistic, particularly if the data exhibit skewness. Moreover, some covariates such as CD4 cell count may be often measured with substantial errors. This paper addresses these issues simultaneously by jointly modeling the response variable with skewness and a covariate process with measurement errors using a Bayesian approach to investigate how estimated parameters are changed or different under these three models. A real data set from an AIDS clinical trial study was used to illustrate the proposed models and methods. It was found that there was a significant incongruity in the estimated decay rates in viral loads based on the three mixed-effects models, suggesting that the decay rates estimated by using Bayesian LME or NLME joint models should be interpreted differently from those estimated by using Bayesian SNLME joint models. The findings also suggest that the Bayesian SNLME joint model is preferred to other models because an arbitrary data truncation is not necessary; and it is also shown that the models with a skew-normal distribution and/or measurement errors in covariate may achieve reliable results when the data exhibit skewness. PMID:22848189

  10. A novel skew analysis reveals substitution asymmetries linked to genetic code GC-biases and PolIII a-subunit isoforms

    PubMed Central

    Apostolou-Karampelis, Konstantinos; Nikolaou, Christoforos; Almirantis, Yannis

    2016-01-01

    Strand biases reflect deviations from a null expectation of DNA evolution that assumes strand-symmetric substitution rates. Here, we present strong evidence that nearest-neighbour preferences are a strand-biased feature of bacterial genomes, indicating neighbour-dependent substitution asymmetries. To detect such asymmetries we introduce an alignment free index (relative abundance skews). The profiles of relative abundance skews along coding sequences can trace the phylogenetic relations of bacteria, suggesting that the patterns of neighbour-dependent substitution strand-biases are not common among different lineages, but are rather species-specific. Analysis of neighbour-dependent and codon-site skews sheds light on the origins of substitution asymmetries. Via a simple model we argue that the structure of the genetic code imposes position-dependent substitution strand-biases along coding sequences, as a response to GC mutation pressure. Thus, the organization of the genetic code per se can lead to an uneven distribution of nucleotides among different codon sites, even when requirements for specific codons and amino-acids are not accounted for. Moreover, our results suggest that strand-biases in replication fidelity of PolIII α-subunit induce substitution asymmetries, both neighbour-dependent and independent, on a genome scale. The role of DNA repair systems, such as transcription-coupled repair, is also considered. PMID:27345720

  11. Digital-map grids of mean-annual precipitation for 1961-90, and generalized skew coefficients of annual maximum streamflow for Oklahoma

    USGS Publications Warehouse

    Rea, A.H.; Tortorelli, R.L.

    1997-01-01

    This digital report contains two digital-map grids of data that were used to develop peak-flow regression equations in Tortorelli, 1997, 'Techniques for estimating peak-streamflow frequency for unregulated streams and streams regulated by small floodwater retarding structures in Oklahoma,' U.S. Geological Survey Water-Resources Investigations Report 97-4202. One data set is a grid of mean annual precipitation, in inches, based on the period 1961-90, for Oklahoma. The data set was derived from the PRISM (Parameter-elevation Regressions on Independent Slopes Model) mean annual precipitation grid for the United States, developed by Daly, Neilson, and Phillips (1994, 'A statistical-topographic model for mapping climatological precipitation over mountainous terrain:' Journal of Applied Meteorology, v. 33, no. 2, p. 140-158). The second data set is a grid of generalized skew coefficients of logarithms of annual maximum streamflow for Oklahoma streams less than or equal to 2,510 square miles in drainage area. This grid of skew coefficients is taken from figure 11 of Tortorelli and Bergman, 1985, 'Techniques for estimating flood peak discharges for unregulated streams and streams regulated by small floodwater retarding structures in Oklahoma,' U.S. Geological Survey Water-Resources Investigations Report 84-4358. To save disk space, the skew coefficient values have been multiplied by 100 and rounded to integers with two significant digits. The data sets are provided in an ASCII grid format.

  12. Highly skewed sex ratios and biased fossil deposition of moa: ancient DNA provides new insight on New Zealand's extinct megafauna

    NASA Astrophysics Data System (ADS)

    Allentoft, Morten E.; Bunce, Michael; Scofield, R. Paul; Hale, Marie L.; Holdaway, Richard N.

    2010-03-01

    Ancient DNA was isolated from the bones of 267 individuals of the extinct New Zealand moa (Aves: Dinornithiformes) from two late Holocene deposits [Pyramid Valley (PV) and Bell Hill Vineyard (BHV)] located 5.7 km apart in North Canterbury, South Island. The two sites' combined fossil record cover the last 3000 years of pre-human New Zealand and mitochondrial DNA confirmed that four species ( Dinornis robustus, Euryapteryx curtus, Emeus crassus, and Pachyornis elephantopus) were sympatric in the region. However, the relative species compositions in the two deposits differed significantly with D. robustus and E. crassus being most abundant at PV while E. curtus outnumbered the other three moa taxa combined at BHV. A subsample of 227 individuals had sufficient nuclear DNA preservation to warrant the use of molecular sexing techniques, and the analyses uncovered a remarkable excess of females in both deposits with an overall male to female ratio of 1:5.1. Among juveniles of E. curtus, the only species which was represented by a substantial fraction of juveniles, the sex ratio was not skewed (10 ♂, 10 ♀), suggesting that the observed imbalance arose as a result of differential mortality during maturation. Surprisingly, sex ratios proved significantly different between sites with a 1:2.2 ratio at BHV ( n = 90) and 1:14.2 at PV ( n = 137). Given the mobility of large ratites, and the proximity of the two fossil assemblages in space and time, these differences in taxonomic and gender composition indicate that moa biology and the local environment have affected the fossil representation dramatically and several possible explanations are offered. Apart from adding to our understanding of moa biology, these discoveries reinforce the need for caution when basing interpretation of the fossil record on material from a single site.

  13. HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells.

    PubMed

    Riou, Catherine; Strickland, Natalie; Soares, Andreia P; Corleis, Björn; Kwon, Douglas S; Wherry, E John; Wilkinson, Robert J; Burgers, Wendy A

    2016-04-01

    HIV-infected persons are at greater risk of developing tuberculosis (TB) even before profound CD4 loss occurs, suggesting that HIV alters CD4(+) T cell functions capable of containing bacterial replication. An effective immune response to Mycobacterium tuberculosis most likely relies on the development of a balanced CD4 response, in which distinct CD4(+) Th subsets act in synergy to control the infection. To define the diversity of M. tuberculosis-specific CD4(+) Th subsets and determine whether HIV infection impacts such responses, the expression of lineage-defining transcription factors T-bet, Gata3, RORγt, and Foxp3 was measured in M. tuberculosis-specific CD4(+) T cells in HIV-uninfected (n = 20) and HIV-infected individuals (n = 20) with latent TB infection. Our results show that, upon 5-d restimulation in vitro, M. tuberculosis-specific CD4(+) T cells from healthy individuals have the ability to exhibit a broad spectrum of Th subsets, defined by specific patterns of transcription factor coexpression. These transcription factor profiles were skewed in HIV-infected individuals where the proportion of T-bet(high)Foxp3(+) M. tuberculosis-specific CD4(+) T cells was significantly decreased (p = 0.002) compared with HIV-uninfected individuals, a change that correlated inversely with HIV viral load (p = 0.0007) and plasma TNF-α (p = 0.027). Our data demonstrate an important balance in Th subset diversity defined by lineage-defining transcription factor coexpression profiles that is disrupted by HIV infection and suggest a role for HIV in impairing TB immunity by altering the equilibrium of M. tuberculosis-specific CD4(+) Th subsets.

  14. Human casein alpha s1 (CSN1S1) skews in vitro differentiation of monocytes towards macrophages

    PubMed Central

    2013-01-01

    skews in vitro differentiation of monocytes towards a macrophage-like phenotype. Data is accumulating that functions of CSN1S1 are beyond nutritional properties and include immunomodulatory effects. PMID:24083466

  15. Preparation and structural characterization of cDHAP-cyclic form of dihydroxyacetone phosphate-revealing chair and skew conformations of 1,3,2-dioxaphosphorinane ring.

    PubMed

    Slepokura, Katarzyna

    2013-03-01

    A cyclic form of dihydroxyacetone phosphate, cDHAP, was obtained by the acidic hydrolysis of its dimethyl acetal (MeO)(2)cDHAP, and was crystallized in the hydrate, cDHAP-H (gem-diol; 1,3,2-dioxaphosphinane-2,5,5-triol 2-oxide) and the ketone, cDHAP-K (2-hydroxy-1,3,2-dioxaphosphinan-5-one 2-oxide) forms. The synthesis, MS and NMR analyses, crystallization and solid state structures determined by X-ray crystallography are described. The equilibrium state between the hydrate and ketone was established, revealing ∼86% of cDHAP-H in aqueous solution at room temperature. The striking structural feature of the ketone and hydrate forms of the same cyclic phosphate diester in the crystalline state is different conformations of the six-membered P/O/C/C/C/O 1,3,2-dioxaphosphorinane ring, namely chair (C) in cDHAP-H·H2O (9a-H) and skew (S) in cDHAP-K (9a-K). Apart from one previous report on the non-chair-puckered, disordered [(MeO)2cDHAP]- anion in the crystal of its ammonium salt (Ślepokura, K. Carbohydr. Res. 2008, 343, 113-131), this is the unique example of the cyclic phosphate diester in skew conformation. Both 9a-H and 9a-K crystallize with the phosphate group protonated, which has been so far rarely observed in the cyclic phosphates. Deformation of the phosphate group and flattening of the chair-puckered ring in 9a-H is typical of protonated P/O/C/C/C/O rings. However, the skew-puckered 9a-K shows different values of O-P-O angles versus the same lengths of P-O(endo) and P-O(exo) bonds. PMID:23353635

  16. Skewed T-helper (Th)1/2- and Th17/T regulatory‑cell balances in patients with renal cell carcinoma.

    PubMed

    Li, Long; Yang, Cheng; Zhao, Zitong; Xu, Bin; Zheng, Minghuan; Zhang, Chao; Min, Zhihui; Guo, Jianming; Rong, Ruiming

    2015-02-01

    The characterization of CD4+ T-cell subsets reflects the immune status and is important in the maintenance of tumorigenesis and homeostasis. To identify changes in the balance of T helper (Th)1, Th2, Th17 and regulatory T cells (Treg) in individuals with renal cell carcinoma (RCC), the present study investigated a total of 131 patients with RCC and 36 healthy volunteers. The number of CD4+ T‑bet+ cells, CD4+ GATA binding protein 3+ cells, CD4+ RAR-related orphan receptor γt+ cells, CD4+ CD25hi CD127lo CD45RA‑ cells and CD4+ CD25hi CD127lo CD45RA+ cells, defined as Th1, Th2, Th17, activated and naïve Treg cells, respectively, were detected in the peripheral blood using flow cytometric analysis. In addition, tumor‑infiltrating forkhead box P3 (Foxp3)+ cells were examined using immunohistochemistry. Compared with healthy volunteers, a significant decrease in the peripheral percentages of Th1, activated and naïve Treg cells was observed in patients with RCC, while those of the Th2 and Th17 cells were increased. In particular, as the tumor stage and grade progressed, the levels of Th1, activated and naïve Treg cells in the peripheral blood decreased; however, the levels of Th2 and Th17 cells increased. Furthermore, the number of tumor-infiltrating Foxp3+ cells increased with increasing tumor stage. These results demonstrated that the balance of Th1 and Th2 cells was skewed towards the Th2 profile and the balance of Th17 and Treg cells was skewed towards the Th17 profile in the peripheral blood of patients with renal cell carcinoma (RCC) and Treg cells were recruited to the tumor sites. Therefore, dysfunctional host anti‑tumor immunity was observed in patients with RCC, with a skewed Th1/Th2 and Th17/Treg balance.

  17. p-hacking by post hoc selection with multiple opportunities: Detectability by skewness test?: Comment on Simonsohn, Nelson, and Simmons (2014).

    PubMed

    Ulrich, Rolf; Miller, Jeff

    2015-12-01

    Simonsohn, Nelson, and Simmons (2014) have suggested a novel test to detect p-hacking in research, that is, when researchers report excessive rates of "significant effects" that are truly false positives. Although this test is very useful for identifying true effects in some cases, it fails to identify false positives in several situations when researchers conduct multiple statistical tests (e.g., reporting the most significant result). In these cases, p-curves are right-skewed, thereby mimicking the existence of real effects even if no effect is actually present. PMID:26595841

  18. p-hacking by post hoc selection with multiple opportunities: Detectability by skewness test?: Comment on Simonsohn, Nelson, and Simmons (2014).

    PubMed

    Ulrich, Rolf; Miller, Jeff

    2015-12-01

    Simonsohn, Nelson, and Simmons (2014) have suggested a novel test to detect p-hacking in research, that is, when researchers report excessive rates of "significant effects" that are truly false positives. Although this test is very useful for identifying true effects in some cases, it fails to identify false positives in several situations when researchers conduct multiple statistical tests (e.g., reporting the most significant result). In these cases, p-curves are right-skewed, thereby mimicking the existence of real effects even if no effect is actually present.

  19. Skew-t fits to mortality data--can a Gaussian-related distribution replace the Gompertz-Makeham as the basis for mortality studies?

    PubMed

    Clark, Jeremy S C; Kaczmarczyk, Mariusz; Mongiało, Zbigniew; Ignaczak, Paweł; Czajkowski, Andrzej A; Klęsk, Przemysław; Ciechanowicz, Andrzej

    2013-08-01

    Gompertz-related distributions have dominated mortality studies for 187 years. However, nonrelated distributions also fit well to mortality data. These compete with the Gompertz and Gompertz-Makeham data when applied to data with varying extents of truncation, with no consensus as to preference. In contrast, Gaussian-related distributions are rarely applied, despite the fact that Lexis in 1879 suggested that the normal distribution itself fits well to the right of the mode. Study aims were therefore to compare skew-t fits to Human Mortality Database data, with Gompertz-nested distributions, by implementing maximum likelihood estimation functions (mle2, R package bbmle; coding given). Results showed skew-t fits obtained lower Bayesian information criterion values than Gompertz-nested distributions, applied to low-mortality country data, including 1711 and 1810 cohorts. As Gaussian-related distributions have now been found to have almost universal application to error theory, one conclusion could be that a Gaussian-related distribution might replace Gompertz-related distributions as the basis for mortality studies.

  20. Expected constraints on models of the epoch of reionization with the variance and skewness in redshifted 21 cm-line fluctuations

    NASA Astrophysics Data System (ADS)

    Kubota, Kenji; Yoshiura, Shintaro; Shimabukuro, Hayato; Takahashi, Keitaro

    2016-08-01

    The redshifted 21 cm-line signal from neutral hydrogen in the intergalactic medium (IGM) gives a direct probe of the epoch of reionization (EoR). In this paper, we investigate the potential of the variance and skewness of the probability distribution function of the 21 cm brightness temperature for constraining EoR models. These statistical quantities are simple, easy to calculate from the observed visibility, and thus suitable for the early exploration of the EoR with current telescopes such as the Murchison Widefield Array (MWA) and LOw Frequency ARray (LOFAR). We show, by performing Fisher analysis, that the variance and skewness at z = 7-9 are complementary to each other to constrain the EoR model parameters such as the minimum virial temperature of halos which host luminous objects, ionizing efficiency, and mean free path of ionizing photons in the IGM. Quantitatively, the constraining power highly depends on the quality of the foreground subtraction and calibration. We give a best case estimate of the constraints on the parameters, neglecting the systematics other than the thermal noise.

  1. The Atacama Cosmology Telescope: A Measurement of the Thermal Sunyaev-Zel'dovich Effect Using the Skewness of the CMB Temperature Distribution

    NASA Technical Reports Server (NTRS)

    Wilson, Michael J.; Sherwin, Blake D.; Hill, J. Collin; Addison, Graeme; Battaglia, Nick; Bond, J. Richard; Das, Sudeep; Devlin, Mark J.; Dunkley, Joanna; Duenner, Rolando; Fowler, Joseph W.; Gralla, Megan, B.; Hajian, Amir; Halpern, Mark; Hilton, Matt; Hincks, Adam D.; Hlozek, Renee; Huffenberger, Kevin; Hughes, John P.; Kosowsky, Arthur; Louis, Thibaut; Marriage, Tobias A.; Marsden, Danica; Menanteau, Felipe; Wollack, Ed

    2012-01-01

    We present a detection of the unnormalized skewness (T(sup )(sup 2)(n(circumflex)) induced by the thermal Sunyaev-Zel'dovich (tSZ) effect in filtered Atacama Cosmology Telescope (ACT) 148 GHz cosmic microwave background temperature maps. Contamination due to infrared and radio sources is minimized by template subtraction of resolved sources and by constructing a mask using outlying values in the 218 GHz (tSZ-null) ACT maps. We measure (T(sup )(sup 3) (n(circumflex)) = -31 plus or minus 6 micro-K(sup 3) (measurement error only) or plus or minus 14 micro-K(sup 3) (including cosmic variance error) in the filtered ACT data, a 5sigma detection. We show that the skewness is a sensitive probe of sigma(sub 8), and use analytic calculations and tSZ simulations to obtain cosmological constraints from this measurement. From this signal alone we infer a value of sigma(sub 8) = 0.78 sup +0.03 sub -0.04 (68% C.L.) sup +0.05 sub -0.16. Our results demonstrate that measurements of nonGaussianity can be a useful method for characterizing the tSZ effect and extracting the underlying cosmological information.

  2. Flexible mixture modeling via the multivariate t distribution with the Box-Cox transformation: an alternative to the skew-t distribution

    PubMed Central

    Lo, Kenneth

    2011-01-01

    Cluster analysis is the automated search for groups of homogeneous observations in a data set. A popular modeling approach for clustering is based on finite normal mixture models, which assume that each cluster is modeled as a multivariate normal distribution. However, the normality assumption that each component is symmetric is often unrealistic. Furthermore, normal mixture models are not robust against outliers; they often require extra components for modeling outliers and/or give a poor representation of the data. To address these issues, we propose a new class of distributions, multivariate t distributions with the Box-Cox transformation, for mixture modeling. This class of distributions generalizes the normal distribution with the more heavy-tailed t distribution, and introduces skewness via the Box-Cox transformation. As a result, this provides a unified framework to simultaneously handle outlier identification and data transformation, two interrelated issues. We describe an Expectation-Maximization algorithm for parameter estimation along with transformation selection. We demonstrate the proposed methodology with three real data sets and simulation studies. Compared with a wealth of approaches including the skew-t mixture model, the proposed t mixture model with the Box-Cox transformation performs favorably in terms of accuracy in the assignment of observations, robustness against model misspecification, and selection of the number of components. PMID:22125375

  3. Estimation of flood discharges at selected annual exceedance probabilities for unregulated, rural streams in Vermont, with a section on Vermont regional skew regression

    USGS Publications Warehouse

    Olson, Scott A.; with a section by Veilleux, Andrea G.

    2014-01-01

    This report provides estimates of flood discharges at selected annual exceedance probabilities (AEPs) for streamgages in and adjacent to Vermont and equations for estimating flood discharges at AEPs of 50-, 20-, 10-, 4-, 2-, 1-, 0.5-, and 0.2-percent (recurrence intervals of 2-, 5-, 10-, 25-, 50-, 100-, 200-, and 500-years, respectively) for ungaged, unregulated, rural streams in Vermont. The equations were developed using generalized least-squares regression. Flood-frequency and drainage-basin characteristics from 145 streamgages were used in developing the equations. The drainage-basin characteristics used as explanatory variables in the regression equations include drainage area, percentage of wetland area, and the basin-wide mean of the average annual precipitation. The average standard errors of prediction for estimating the flood discharges at the 50-, 20-, 10-, 4-, 2-, 1-, 0.5-, and 0.2-percent AEP with these equations are 34.9, 36.0, 38.7, 42.4, 44.9, 47.3, 50.7, and 55.1 percent, respectively. Flood discharges at selected AEPs for streamgages were computed by using the Expected Moments Algorithm. To improve estimates of the flood discharges for given exceedance probabilities at streamgages in Vermont, a new generalized skew coefficient was developed. The new generalized skew for the region is a constant, 0.44. The mean square error of the generalized skew coefficient is 0.078. This report describes a technique for using results from the regression equations to adjust an AEP discharge computed from a streamgage record. This report also describes a technique for using a drainage-area adjustment to estimate flood discharge at a selected AEP for an ungaged site upstream or downstream from a streamgage. The final regression equations and the flood-discharge frequency data used in this study will be available in StreamStats. StreamStats is a World Wide Web application providing automated regression-equation solutions for user-selected sites on streams.

  4. Method and structure for skewed block-cyclic distribution of lower-dimensional data arrays in higher-dimensional processor grids

    DOEpatents

    Chatterjee, Siddhartha; Gunnels, John A.

    2011-11-08

    A method and structure of distributing elements of an array of data in a computer memory to a specific processor of a multi-dimensional mesh of parallel processors includes designating a distribution of elements of at least a portion of the array to be executed by specific processors in the multi-dimensional mesh of parallel processors. The pattern of the designating includes a cyclical repetitive pattern of the parallel processor mesh, as modified to have a skew in at least one dimension so that both a row of data in the array and a column of data in the array map to respective contiguous groupings of the processors such that a dimension of the contiguous groupings is greater than one.

  5. Hydrologic and geochemical data collected near Skewed Reservoir, an impoundment for coal-bed natural gas produced water, Powder River Basin, Wyoming

    USGS Publications Warehouse

    Healy, Richard W.; Rice, Cynthia A.; Bartos, Timothy T.

    2012-01-01

    The Powder River Structural Basin is one of the largest producers of coal-bed natural gas (CBNG) in the United States. An important environmental concern in the Basin is the fate of groundwater that is extracted during CBNG production. Most of this produced water is disposed of in unlined surface impoundments. A 6-year study of groundwater flow and subsurface water and soil chemistry was conducted at one such impoundment, Skewed Reservoir. Hydrologic and geochemical data collected as part of that study are contained herein. Data include chemistry of groundwater obtained from a network of 21 monitoring wells and three suction lysimeters and chemical and physical properties of soil cores including chemistry of water/soil extracts, particle-size analyses, mineralogy, cation-exchange capacity, soil-water content, and total carbon and nitrogen content of soils.

  6. First-principles evaluation of intrinsic, side-jump, and skew-scattering parts of anomalous Hall conductivities in disordered alloys

    NASA Astrophysics Data System (ADS)

    Hyodo, K.; Sakuma, A.; Kota, Y.

    2016-09-01

    We develop a first-principles procedure for the individual evaluation of the intrinsic, side-jump, and skew-scattering contributions to the anomalous Hall conductivity σx y. This method is based on the different microscopic conductive processes of each origin of σx y in the Kubo-Bastin formula. We also present an approach for implementing this scheme in the tight-binding linear muffin-tin orbital (TB-LMTO) method with the coherent potential approximation (CPA). The validity of this calculation method is demonstrated for disordered FePt and FePd alloys. We find that the estimated value of each origin of σx y exhibits reasonable dependencies on the electron scattering in these disordered alloys.

  7. Incorporation of 5-ethynyl-2'-deoxyuridine (EdU) as a novel strategy for identification of the skewed X inactivation pattern in balanced and unbalanced X-rearrangements.

    PubMed

    Sisdelli, Luiza; Vidi, Angela Cristina; Moysés-Oliveira, Mariana; Di Battista, Adriana; Bortolai, Adriana; Moretti-Ferreira, Danilo; da Silva, Magnus R Dias; Melaragno, Maria Isabel; Carvalheira, Gianna

    2016-02-01

    X-chromosome inactivation occurs randomly in normal female cells. However, the inactivation can be skewed in patients with alterations in X-chromosome. In balanced X-autosome translocations, normal X is preferentially inactivated, while in unbalanced X alterations, the aberrant X is usually inactivated. Here, we present a novel strategy to verify the skewed X inactivation pattern through the incorporation of 5-ethynyl-2'-deoxyuridine (EdU) into cells, in 11 patients: five carriers of balanced X-autosome translocations and six of unbalanced X-chromosome alterations. Since EdU is a labeled nucleoside analog of thymidine, its incorporation during DNA synthesis can reveal late replication regions and the inactive X-chromosome. All EdU findings were validated by the human androgen receptor gene (HUMARA) assay. The late replication regions were easily and quickly visualized in all cells, where inactive Xs are marked with strong green fluorescence. It was observed that the normal X-chromosome was preferentially inactivated in patients with balanced X-autosome translocations; while the aberrant X-chromosome was inactivated in most cells from patients with unbalanced alterations. By performing the fluorescence-based EdU assay, the differences between the active and inactive X-chromosomes are more easily recognizable than by classic cytogenetic methods. Furthermore, EdU incorporation allows the observation of the late replication regions in autosomal segments present in X derivatives from X-autosome translocations. Therefore, EdU assay permits an accurate and efficient cytogenetic evaluation of the X inactivation pattern with a low-cost, easy to perform and highly reproducible technique. PMID:26670424

  8. Heavy metal mediated innate immune responses of the Indian green frog, Euphlyctis hexadactylus (Anura: Ranidae): Cellular profiles and associated Th1 skewed cytokine response.

    PubMed

    Jayawardena, Uthpala A; Ratnasooriya, Wanigasekara D; Wickramasinghe, Deepthi D; Udagama, Preethi V

    2016-10-01

    Immune cell and cytokine profiles in relation to metal exposure though much studied in mammals has not been adequately investigated in amphibians, due mainly to lack of suitable reagents for cytokine profiling in non-model species. However, interspecies cross reactivity of cytokines permitted us to assay levels of IFNγ, TNFα, IL6 and IL10in a common anuran, the Indian green frog (Euphlyctis hexadactylus), exposed to heavy metals (Cd, Cr, Cu, Zn and Pb, at ~5ppm each) under field and laboratory settings in Sri Lanka. Enumeration of immune cells in blood and melanomacrophages in the liver, assay of serum and hepatic cytokines, and Th1/Th2 cytokine polarisation were investigated. Immune cell counts indicated overall immunosuppression with decreasing total WBC and splenocyte counts while neutrophil/lymphocyte ratio increased with metal exposure, indicating metal mediated stress. Serum IL6 levels of metal exposed frogs reported the highest (~9360pg/mL) of all cytokines tested. Significantly elevated IFNγ production (P<0.05) was evident in heavy metal exposed frogs. Th1/Th2 cytokine ratio in both serum and liver tissue homogenates was Th1 skewed due to significantly higher production of pro-inflammatory cytokines, IFNγ in serum and TNFα in the liver (P<0.01).Metal mediated aggregations of melanomacrophages in the liver were positively and significantly (P<0.05) correlated with the hepatic expression of TNFα, IL6 and IL10 activity. Overall, Th1 skewed response may well be due to oxidative stress mediated nuclear factor κ-light chain enhancer of activated B cells (NFκB) which enhances the transcription of pro-inflammatory cytokines. Xenobiotic stress has recently imposed an unprecedented level of threat to wildlife, particularly to sensitive species such as amphibians. Therefore, understanding the interactions between physiological stress and related immune responses is fundamental to conserve these environmental sentinels in the face of emerging eco

  9. Heavy metal mediated innate immune responses of the Indian green frog, Euphlyctis hexadactylus (Anura: Ranidae): Cellular profiles and associated Th1 skewed cytokine response.

    PubMed

    Jayawardena, Uthpala A; Ratnasooriya, Wanigasekara D; Wickramasinghe, Deepthi D; Udagama, Preethi V

    2016-10-01

    Immune cell and cytokine profiles in relation to metal exposure though much studied in mammals has not been adequately investigated in amphibians, due mainly to lack of suitable reagents for cytokine profiling in non-model species. However, interspecies cross reactivity of cytokines permitted us to assay levels of IFNγ, TNFα, IL6 and IL10in a common anuran, the Indian green frog (Euphlyctis hexadactylus), exposed to heavy metals (Cd, Cr, Cu, Zn and Pb, at ~5ppm each) under field and laboratory settings in Sri Lanka. Enumeration of immune cells in blood and melanomacrophages in the liver, assay of serum and hepatic cytokines, and Th1/Th2 cytokine polarisation were investigated. Immune cell counts indicated overall immunosuppression with decreasing total WBC and splenocyte counts while neutrophil/lymphocyte ratio increased with metal exposure, indicating metal mediated stress. Serum IL6 levels of metal exposed frogs reported the highest (~9360pg/mL) of all cytokines tested. Significantly elevated IFNγ production (P<0.05) was evident in heavy metal exposed frogs. Th1/Th2 cytokine ratio in both serum and liver tissue homogenates was Th1 skewed due to significantly higher production of pro-inflammatory cytokines, IFNγ in serum and TNFα in the liver (P<0.01).Metal mediated aggregations of melanomacrophages in the liver were positively and significantly (P<0.05) correlated with the hepatic expression of TNFα, IL6 and IL10 activity. Overall, Th1 skewed response may well be due to oxidative stress mediated nuclear factor κ-light chain enhancer of activated B cells (NFκB) which enhances the transcription of pro-inflammatory cytokines. Xenobiotic stress has recently imposed an unprecedented level of threat to wildlife, particularly to sensitive species such as amphibians. Therefore, understanding the interactions between physiological stress and related immune responses is fundamental to conserve these environmental sentinels in the face of emerging eco-challenges.

  10. The LMNA mutation p.Arg321Ter associated with dilated cardiomyopathy leads to reduced expression and a skewed ratio of lamin A and lamin C proteins

    SciTech Connect

    Al-Saaidi, Rasha; Rasmussen, Torsten B.; Palmfeldt, Johan; Nissen, Peter H.; Beqqali, Abdelaziz; Hansen, Jakob; Pinto, Yigal M.; Boesen, Thomas; Mogensen, Jens; Bross, Peter

    2013-11-15

    heterozygosity for the nonsense mutation causes NMD degradation of the mutant transcripts blocking expression of the truncated mutant protein and an additional trans effect on lamin A protein levels expressed from the wild type allele. We discuss the possibility that skewing of the lamin A to lamin C ratio may contribute to ensuing processes that destabilize cardiomyocytes and trigger cardiomyopathy - Highlights: • We study disease mechanisms in DCM patients carrying PTC mutations in the LMNA gene. • The mutant transcript is degraded by the nonsense mediated mRNA decay system. • Skewed lamin A to lamin C protein ratio expressed from the wild type allele. • We suggest a combined pathomechanism: haploinsuffiency plus lamin A/C imbalance.

  11. A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection.

    PubMed

    Bacchus, Charline; Cheret, Antoine; Avettand-Fenoël, Véronique; Nembot, Georges; Mélard, Adeline; Blanc, Catherine; Lascoux-Combe, Caroline; Slama, Laurence; Allegre, Thierry; Allavena, Clotilde; Yazdanpanah, Yazdan; Duvivier, Claudine; Katlama, Christine; Goujard, Cécile; Seksik, Bao Chau Phung; Leplatois, Anne; Molina, Jean-Michel; Meyer, Laurence; Autran, Brigitte; Rouzioux, Christine

    2013-01-01

    Optimizing therapeutic strategies for an HIV cure requires better understanding the characteristics of early HIV-1 spread among resting CD4+ cells within the first month of primary HIV-1 infection (PHI). We studied the immune distribution, diversity, and inducibility of total HIV-DNA among the following cell subsets: monocytes, peripheral blood activated and resting CD4 T cells, long-lived (naive [TN] and central-memory [TCM]) and short-lived (transitional-memory [TTM] and effector-memory cells [TEM]) resting CD4+T cells from 12 acutely-infected individuals recruited at a median 36 days from infection. Cells were sorted for total HIV-DNA quantification, phylogenetic analysis and inducibility, all studied in relation to activation status and cell signaling. One month post-infection, a single CCR5-restricted viral cluster was massively distributed in all resting CD4+ subsets from 88% subjects, while one subject showed a slight diversity. High levels of total HIV-DNA were measured among TN (median 3.4 log copies/million cells), although 10-fold less (p = 0.0005) than in equally infected TCM (4.5), TTM (4.7) and TEM (4.6) cells. CD3-CD4+ monocytes harbored a low viral burden (median 2.3 log copies/million cells), unlike equally infected resting and activated CD4+ T cells (4.5 log copies/million cells). The skewed repartition of resting CD4 subsets influenced their contribution to the pool of resting infected CD4+T cells, two thirds of which consisted of short-lived TTM and TEM subsets, whereas long-lived TN and TCM subsets contributed the balance. Each resting CD4 subset produced HIV in vitro after stimulation with anti-CD3/anti-CD28+IL-2 with kinetics and magnitude varying according to subset differentiation, while IL-7 preferentially induced virus production from long-lived resting TN cells. In conclusion, within a month of infection, a clonal HIV-1 cluster is massively distributed among resting CD4 T-cell subsets with a flexible inducibility, suggesting that

  12. True Polar Wander and Hotspot Fixity: A Paleomagnetic Investigation of the Skewness of Magnetic Anomaly 12r (32 Ma B.P.) on the Pacific Plate

    NASA Astrophysics Data System (ADS)

    Gordon, R. G.; Horner-Johnson, B. C.

    2010-12-01

    Prior studies have shown that Pacific hotspots and Indo-Atlantic hotspots have moved in approximate unison relative to the spin axis since 65 Ma B.P. [Morgan, 1981; Gordon and Cape, 1981; Gordon, 1982] and since 56 Ma B.P. [Petronotis et al., 1994], which is most simply interpreted as true polar wander. In contrast, Pacific hotspots and Indo-Atlantic hotspots give conflicting results for 72 Ma B.P. and for 81 Ma B.P., which may indicate motion between Pacific hotspots and Indo-Atlantic hotspots [Tarduno and Cottrell, 1997; Petronotis et al., 1999; Tarduno et al., 2003]. Thus it is important to estimate Pacific plate apparent polar wander (APW) for more time intervals. From such estimates the APW of Pacific hotspots can be inferred and compared with that of Indo-Atlantic hotspots [e.g., Besse and Courtillot 2002]. Here we present a study of the skewness of anomaly 12r between the Galapagos and Clipperton and between the Clipperton and Clarion fracture zones. We chose this region for several reasons: First, numerical experiments, like those conducted by Acton and Gordon [1991], indicate that magnetic profiles between the Galapagos and Clarion fracture zones should contain the most information about the Pacific plate paleomagnetic pole for chron C12r (32 Ma B.P.). Second, in these two spreading rate corridors, spreading half rates range from 72 to 86 mm/a and therefore have negligible anomalous skewness, given that they exceed ≈50 mm/a [Roest et al., 1992; Dyment et al. 1994]. Third, vector aeromagnetic profiles are available for analysis. One of the challenges to interpreting magnetic anomalies in low latitudes where the anomalies strike nearly north-south is the very low amplitude of the signal relative to the noise, the latter of which can be especially intense near the present magnetic equator due to the amplification of diurnal variation by the equatorial electrojet. Previously we showed that vector aeromagnetic profiles record low-latitude Pacific plate

  13. Treatment to sustain a Th17-type phenotype to prevent skewing toward Treg and to limit premalignant lesion progression to cancer.

    PubMed

    Young, M Rita I; Levingston, Corinne A; Johnson, Sara D

    2016-05-15

    While immune suppression is a hallmark of head and neck squamous cell carcinoma (HSNCC), the immunological impact of premalignant oral lesions, which often precedes development of HNSCC, is unknown. The present study assessed the changes in splenic and draining lymph node CD4(+) cell populations and their production of select cytokines that occur in mice with carcinogen-induced premalignant oral lesions and the changes that occur as lesions progress to oral cancer. These studies found skewing toward Th1 and Th17-type phenotypes in the spleen and lymph nodes of mice with premalignant oral lesions and a shift to Treg as lesions progress to cancer. Since the role of Th17 cells in the progression from premalignant lesions to cancer is not clear, studies determined the immunological and clinical effect of treating mice bearing premalignant oral lesions with a TGF-β type 1 receptor inhibitor plus IL-23 as an approach to sustain the Th17 phenotype. These studies showed that the treatment approach not only sustained the Th17 phenotype, but also increased distal spleen cell and regional lymph node cell production of other stimulatory/inflammatory mediators and slowed premalignant lesion progression to cancer.

  14. The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells

    PubMed Central

    1991-01-01

    To ascertain how the actual repertoire of T cell receptors (TCRs) deviates from the theoretical, we have generated a large number of junctional region sequences from TCRs carrying the V beta 17 variable region. The greater than 600 sequences analyzed represent transcripts from nine different cell populations, permitting several comparisons: transcripts from an expressed vs. a non-expressed V beta 17 allele, those from E+ vs. E- mice, transcripts from immature vs. mature thymocytes, those from thymic vs. peripheral T cells, and those from CD4+ vs. CD8+ cells. These comparisons have allowed us to distinguish between the influence of molecular events involved in TCR gene rearrangement and that of various selection events that shape the T cell repertoire. Our most striking findings are: (a) that J beta usage is markedly skewed, partly due to recombination mechanics and partly due to selection forces: in particular, those mediated by the class II E molecule in the thymus; and (b) that TCRs on CD4+ and CD8+ cells show intriguing dissimilarities. In addition, we present evidence that N nucleotide additions occur with clear biases, probably due to idiosyncrasies of the recombination enzymes, and provide arguments that TCR and immunoglobulin CDR3s have distinct structures. PMID:1940807

  15. Antimicrobial peptide LL-37 promotes antigen-specific immune responses in mice by enhancing Th17-skewed mucosal and systemic immunities.

    PubMed

    Kim, Sae-Hae; Yang, In-Young; Kim, Ju; Lee, Kyung-Yeol; Jang, Yong-Suk

    2015-05-01

    The human antimicrobial peptide LL-37 is known to have chemotactic and modulatory activities on various cells including monocytes, T cells, and epithelial cells. Given that LL-37 enhances chemotactic attraction and modulates the activity of DCs, it is conceivable that it might play a role as an immune adjuvant by skewing the immune environment toward immunostimulatory conditions. In this study, we characterized the mucosal adjuvant activity of LL-37 using model and pathogenic Ags. When LL-37-conjugated Ag was administered orally to mice, a tolerogenic Peyer's patch environment was altered to cell populations containing IL-6-secreting CD11c(+), CD11c(+) CD70(+), and Th17 cells capable of evoking a subsequent LL-37-conjugated Ag-specific immune response in both systemic and mucosal immune compartments. In addition, we showed presentation of formyl peptide receptor, an LL-37 receptor, on M cells, which may aid the initiation of an LL-37-mediated enhanced immune response through targeting and transcytosis of the conjugated Ag. Based on our findings, we conclude that LL-37 has potential as an oral mucosal adjuvant, not only by enhancing the delivery of LL-37-conjugated Ag to M cells, but also by triggering T-cell-mediated Ag-specific immune responses through modulation of the mucosal immune environment.

  16. Male-Biased Predation and Its Effect on Paternity Skew and Life History in a Population of Common Brushtail Possums (Trichosurus vulpecula)

    PubMed Central

    DeGabriel, Jane L.; Moore, Ben D.; Foley, William J.; Johnson, Christopher N.

    2014-01-01

    Differences in predation risk may exert strong selective pressures on life history strategies of populations. We investigated the potential for predation to shape male mating strategies in an arboreal folivore, the common brushtail possum (Trichosurus vulpecula Kerr). We predicted that possums in a tropical population exposed to high natural levels of predation would grow faster and reproduce earlier compared to those in temperate populations with lower predation. We trapped a population of possums in eucalypt woodland in northern Australia each month to measure life history traits and used microsatellites to genotype all individuals and assign paternity to all offspring. We observed very high levels of male-biased predation, with almost 60% of marked male possums being eaten by pythons, presumably as a result of their greater mobility due to mate-searching. Male reproductive success was also highly skewed, with younger, larger males fathering significantly more offspring. This result contrasts with previous studies of temperate populations experiencing low levels of predation, where older males were larger and the most reproductively successful. Our results suggest that in populations exposed to high levels of predation, male possums invest in increased growth earlier in life, in order to maximise their mating potential. This strategy is feasible because predation limits competition from older males and means that delaying reproduction carries a risk of failing to reproduce at all. Our results show that life histories are variable traits that can match regional predation environments in mammal species with widespread distributions. PMID:25372294

  17. Decreased IL7Rα and TdT expression underlie the skewed immunoglobulin repertoire of human B-cell precursors from fetal origin

    PubMed Central

    Rother, Magdalena B.; Jensen, Kristin; van der Burg, Mirjam; van de Bovenkamp, Fleur S.; Kroek, Roel; van IJcken, Wilfred F. J.; van der Velden, Vincent H. J.; Cupedo, Tom; Olstad, Ole K.; van Dongen, Jacques J. M.; van Zelm, Menno C.

    2016-01-01

    Newborns are unable to mount antibody responses towards certain antigens. This has been related to the restricted repertoire of immunoglobulin (Ig) genes of their B cells. The mechanisms underlying the restricted fetal Ig gene repertoire are currently unresolved. We here addressed this with detailed molecular and cellular analysis of human precursor-B cells from fetal liver, fetal bone marrow (BM), and pediatric BM. In the absence of selection processes, fetal B-cell progenitors more frequently used proximal V, D and J genes in complete IGH gene rearrangements, despite normal Ig locus contraction. Fewer N-nucleotides were added in IGH gene rearrangements in the context of low TdT and XRCC4 expression. Moreover, fetal progenitor-B cells expressed lower levels of IL7Rα than their pediatric counterparts. Analysis of progenitor-B cells from IL7Rα-deficient patients revealed that TdT expression and N-nucleotides additions in Dh-Jh junctions were dependent on functional IL7Rα. Thus, IL7Rα affects TdT expression, and decreased expression of this receptor underlies at least in part the skewed Ig repertoire formation in fetal B-cell precursors. These new insights provide a better understanding of the formation of adaptive immunity in the developing fetus. PMID:27658954

  18. Favorable outcomes of hydroxychloroquine in insulin resistance may be accomplished by adjustment of the endothelial dysfunction as well as the skewed balance of adipokines.

    PubMed

    Abdel-Hamid, Ahmed A M; Firgany, Alaa El-Din L

    2016-07-01

    Hydroxychloroquine (HCQ) has been demonstrated to reduce the risk to develop diabetes mellitus (DM). However no previous experimental study had investigated its effect on the structure of the endocrine pancreas, islets of Langerhans (IOL), in insulin resistance (IR). In addition, the mechanism by which HCQ can prevent DM is not well understood. In this study, we hypothesized that the possible favorable outcome of HCQ may be partly achieved by its molecular effect on the endothelial stress markers as well as on the imparied balance of the adipokines that usually accompanies IR. A total of 54 rats were divided equally into; control, high fat diet (HFD) and HFD+HCQ groups (received standard chow, HFD and HFD+HCQ respectively). After 12 weeks, samples from pancreas as well as visceral adipose tissue (VAT) were histologically studied for the consequent changes. In the HFD group, there were mild degenerative changes and expansion of the IOL accompanied with a significantly increased (p<0.05) β-cell area%, mass, proliferation and neogenesis as well as a significantly decreased (p<0.05) α-cell area% compared with the other groups. On combining HCQ with HFD, reversal of these changes along with correction of the impaired adipokines levels (leptin, adiponectin, resistin, visfatin and lipocalin-2) and significant decrease (p<0.05) of the vascular endothelial stress markers (sE-selectin, sICAM and sVICAM) were manifested compared with the HFD group. Therefore, HCQ favorable effects in IR may be attributed to relieving of the endothelial stress as well as normalization of the skewed balance of adipokines. PMID:27320898

  19. A unique anti-CD115 monoclonal antibody which inhibits osteolysis and skews human monocyte differentiation from M2-polarized macrophages toward dendritic cells.

    PubMed

    Haegel, Hélène; Thioudellet, Christine; Hallet, Rémy; Geist, Michel; Menguy, Thierry; Le Pogam, Fabrice; Marchand, Jean-Baptiste; Toh, Myew-Ling; Duong, Vanessa; Calcei, Alexandre; Settelen, Nathalie; Preville, Xavier; Hennequi, Marie; Grellier, Benoit; Ancian, Philippe; Rissanen, Jukka; Clayette, Pascal; Guillen, Christine; Rooke, Ronald; Bonnefoy, Jean-Yves

    2013-01-01

    Cancer progression has been associated with the presence of tumor-associated M2-macrophages (M2-TAMs) able to inhibit anti-tumor immune responses. It is also often associated with metastasis-induced bone destruction mediated by osteoclasts. Both cell types are controlled by the CD115 (CSF-1R)/colony-stimulating factor-1 (CSF-1, M-CSF) pathway, making CD115 a promising target for cancer therapy. Anti-human CD115 monoclonal antibodies (mAbs) that inhibit the receptor function have been generated in a number of laboratories. These mAbs compete with CSF-1 binding to CD115, dramatically affecting monocyte survival and preventing osteoclast and macrophage differentiation, but they also block CD115/CSF-1 internalization and degradation, which could lead to potent rebound CSF-1 effects in patients after mAb treatment has ended. We thus generated and selected a non-ligand competitive anti-CD115 mAb that exerts only partial inhibitory effects on CD115 signaling without blocking the internalization or the degradation of the CD115/CSF-1 complex. This mAb, H27K15, affects monocyte survival only minimally, but downregulates osteoclast differentiation and activity. Importantly, it inhibits monocyte differentiation to CD163(+)CD64(+) M2-polarized suppressor macrophages, skewing their differentiation toward CD14(-)CD1a(+) dendritic cells (DCs). In line with this observation, H27K15 also drastically inhibits monocyte chemotactic protein-1 secretion and reduces interleukin-6 production; these two molecules are known to be involved in M2-macrophage recruitment. Thus, the non-depleting mAb H27K15 is a promising anti-tumor candidate, able to inhibit osteoclast differentiation, likely decreasing metastasis-induced osteolysis, and able to prevent M2 polarization of TAMs while inducing DCs, hence contributing to the creation of more efficient anti-tumor immune responses. PMID:23924795

  20. A unique anti-CD115 monoclonal antibody which inhibits osteolysis and skews human monocyte differentiation from M2-polarized macrophages toward dendritic cells.

    PubMed

    Haegel, Hélène; Thioudellet, Christine; Hallet, Rémy; Geist, Michel; Menguy, Thierry; Le Pogam, Fabrice; Marchand, Jean-Baptiste; Toh, Myew-Ling; Duong, Vanessa; Calcei, Alexandre; Settelen, Nathalie; Preville, Xavier; Hennequi, Marie; Grellier, Benoit; Ancian, Philippe; Rissanen, Jukka; Clayette, Pascal; Guillen, Christine; Rooke, Ronald; Bonnefoy, Jean-Yves

    2013-01-01

    Cancer progression has been associated with the presence of tumor-associated M2-macrophages (M2-TAMs) able to inhibit anti-tumor immune responses. It is also often associated with metastasis-induced bone destruction mediated by osteoclasts. Both cell types are controlled by the CD115 (CSF-1R)/colony-stimulating factor-1 (CSF-1, M-CSF) pathway, making CD115 a promising target for cancer therapy. Anti-human CD115 monoclonal antibodies (mAbs) that inhibit the receptor function have been generated in a number of laboratories. These mAbs compete with CSF-1 binding to CD115, dramatically affecting monocyte survival and preventing osteoclast and macrophage differentiation, but they also block CD115/CSF-1 internalization and degradation, which could lead to potent rebound CSF-1 effects in patients after mAb treatment has ended. We thus generated and selected a non-ligand competitive anti-CD115 mAb that exerts only partial inhibitory effects on CD115 signaling without blocking the internalization or the degradation of the CD115/CSF-1 complex. This mAb, H27K15, affects monocyte survival only minimally, but downregulates osteoclast differentiation and activity. Importantly, it inhibits monocyte differentiation to CD163(+)CD64(+) M2-polarized suppressor macrophages, skewing their differentiation toward CD14(-)CD1a(+) dendritic cells (DCs). In line with this observation, H27K15 also drastically inhibits monocyte chemotactic protein-1 secretion and reduces interleukin-6 production; these two molecules are known to be involved in M2-macrophage recruitment. Thus, the non-depleting mAb H27K15 is a promising anti-tumor candidate, able to inhibit osteoclast differentiation, likely decreasing metastasis-induced osteolysis, and able to prevent M2 polarization of TAMs while inducing DCs, hence contributing to the creation of more efficient anti-tumor immune responses.

  1. Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.

    PubMed

    Aoki-Ota, Miyo; Torkamani, Ali; Ota, Takayuki; Schork, Nicholas; Nemazee, David

    2012-03-01

    Previous estimates of the diversity of the mouse Ab repertoire have been based on fragmentary data as a result of many technical limitations, in particular, the many samples necessary to provide adequate coverage. In this study, we used 5'-coding end amplification of Igκ mRNAs from bone marrow, splenic, and lymph node B cells of C57BL/6 mice combined with amplicon pyrosequencing to assess the functional and nonfunctional Vκ repertoire. To evaluate the potential effects of receptor editing, we also compared V/J associations and usage in bone marrows of mouse mutants under constitutive negative selection or an altered ability to undergo secondary recombination. To focus on preimmune B cells, our cell sorting strategy excluded memory B cells and plasma cells. Analysis of ~90 Mbp, representing >250,000 individual transcripts from 59 mice, revealed that 101 distinct functional Vκ genes are used but at frequencies ranging from ~0.001 to ~10%. Usage of seven Vκ genes made up >40% of the repertoire. A small class of transcripts from apparently nonfunctional Vκ genes was found, as were occasional transcripts from several apparently functional genes that carry aberrant recombination signals. Of 404 potential V-J combinations (101 Vκs × 4 Jκs), 398 (98.5%) were found at least once in our sample. For most Vκ transcripts, all Jκs were used, but V-J association biases were common. Usage patterns were remarkably stable in different selective conditions. Overall, the primary κ repertoire is highly skewed by preferred rearrangements, limiting Ab diversity, but potentially facilitating receptor editing.

  2. Lagrangian Stochastic Modelling of Dispersion in the Convective Boundary Layer with Skewed Turbulence Conditions and a Vertical Density Gradient: Formulation and Implementation in the FLEXPART Model

    NASA Astrophysics Data System (ADS)

    Cassiani, Massimo; Stohl, Andreas; Brioude, Jerome

    2015-03-01

    A correction for the vertical gradient of air density has been incorporated into a skewed probability density function formulation for turbulence in the convective boundary layer. The related drift term for Lagrangian stochastic dispersion modelling has been derived based on the well-mixed condition. Furthermore, the formulation has been extended to include unsteady turbulence statistics and the related additional component of the drift term obtained. These formulations are an extension of the drift formulation reported by Luhar et al. (Atmos Environ 30:1407-1418, 1996) following the well-mixed condition proposed by Thomson (J Fluid Mech 180:529-556, 1987). Comprehensive tests were carried out to validate the formulations including consistency between forward and backward simulations and preservation of a well-mixed state with unsteady conditions. The stationary state CBL drift term with density correction was incorporated into the FLEXPART and FLEXPART-WRF Lagrangian models, and included the use of an ad hoc transition function that modulates the third moment of the vertical velocity based on stability parameters. Due to the current implementation of the FLEXPART models, only a steady-state horizontally homogeneous drift term could be included. To avoid numerical instability, in the presence of non-stationary and horizontally inhomogeneous conditions, a re-initialization procedure for particle velocity was used. The criteria for re-initialization and resulting errors were assessed for the case of non-stationary conditions by comparing a reference numerical solution in simplified unsteady conditions, obtained using the non-stationary drift term, and a solution based on the steady drift with re-initialization. Two examples of "real-world" numerical simulations were performed under different convective conditions to demonstrate the effect of the vertical gradient in density on the particle dispersion in the CBL.

  3. Scour below submerged skewed pipeline

    NASA Astrophysics Data System (ADS)

    Azamathulla, H. Md.; Yusoff, M. A. M.; Hasan, Z. A.

    2014-02-01

    Local scour below pipelines commonly occurs due to the erosive action of currents and waves. Scour is a major cause for the failure of underwater pipelines which is very important in water resources management. In this study, experiments were conducted to investigate the effect of four different pipeline orientations (30°, 45°, 60° and 90°) across a channel. The data sets of the laboratory measurements were also collected from published works. The temporal variation of local pipelines scour depth was studied to estimate the scour depth. The scour depth below the pipeline was determined using a regression model with five dimensionless parameters. A regression model with a coefficient of determination (R2 = 0.55) and a low root mean square error (RMSE = 0.47) produced fairly good predictions of the relative scour depth. The proposed equation gave satisfactory results when compared with the existing predictors.

  4. Pacific plate apparent polar wander between 67 Ma and 44 Ma determined from the analysis of the skewness of both vector and scalar magnetic anomalies due to seafloor spreading

    NASA Astrophysics Data System (ADS)

    Zheng, L.; Gordon, R. G.; Horner-Johnson, B. C.

    2011-12-01

    Pacific plate apparent polar wander between 67 Ma and 44 Ma determined from the analysis of the skewness of both vector and scalar magnetic anomalies due to seafloor spreading The apparent polar wander (APW) path for the Pacific plate is important to the study of Pacific plate motions and their relation to circum-Pacific tectonics. It can be used to discriminate between alternative plate motion circuits, determine the motion of Pacific hotspots relative to the paleomagnetic axis, and test the fixed hotspot hypothesis. The pioneering investigations of Jean Francheteau and his colleagues of Pacific plate APW through the analysis of magnetic anomalies over seamounts helped to demonstrate that the Pacific plate has had substantial northward motion relative to the spin axis since Cretaceous time. We also investigate the APW of the Pacific plate through analysis of magnetic anomalies. Instead of anomalies over seamounts, however, we investigate the skewness (asymmetry) of magnetic anomalies due to seafloor spreading. In prior work, skewness analysis of shipboard magnetic profiles has been used to determine Pacific paleomagnetic poles for chron 25r (57 Ma B.P.; Petronotis et al., 1994), chron 27r to 31n (62 to 69 Ma B.P.; Acton and Gordon, 1991) and chron 32n (72 Ma B.P.; Petronotis and Gordon, 1999). Recently, vector aeromagnetic data from low paleolatitudes, combined with shipboard profiles from low paleolatitudes, were used to determine a paleomagnetic pole with compact confidence limits for anomaly 12r (32 Ma B.P.; Horner-Johnson and Gordon, 2010). Here we use the low-paleolatitude shipboard- and vector aero-magnetic profiles to determine new paleomagnetic poles for the Pacific plate. A new feature of our analysis is a correction for the spreading-rate dependence of anomalous skewness (Koivisto et al. 2011). We estimate anomalous skewness as a function of spreading rate for each anomaly by creating many synthetic profiles using the model of Dyment and Arkani

  5. The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4+CD25+ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment

    PubMed Central

    Yang, Jiezuan; Sheng, Guoping; Xiao, Dangsheng; Shi, Haiyan; Wu, Wei; Lu, Haifeng; Cao, Hongcui; Li, Lanjuan

    2016-01-01

    The frequency and T-cell receptor beta-chain variable (TCRBV) patterns of peripheral CD4+CD25+ regulatory T-cells (Tregs) are ambiguously altered in chronic hepatitis B (CHB) patients following tenofovir disoproxil fumarate (TDF) treatment. Moreover, the clinical significance of these parameters in relation to hepatitis B e antigen (HBeAg) seroconversion (SC) is largely unknown. In this study, the circulation of Tregs in HBeAg-positive CHB patients was determined by flow cytometry, and the molecular profiles of frequent TCRBV patterns of Tregs were analyzed using a gene melting spectral pattern. The parameters, such as Treg frequency, the number of skewed TCRBV patterns, hepatitis B virus (HBV) DNA levels, and alanine aminotransferase (ALT) levels, were analyzed by comparing their associations in seroconverting and non-seroconverting patients following TDF treatment. The Treg frequency was significantly correlated with the ALT level in seroconverting but not in non-seroconverting patients. Similarly, skewed TCRBV patterns were remarkably associated with HBV DNA levels in the SC group. Six TCRBV families (BV3, BV11, BV12, BV14, BV20, and BV24) were more prevalent than other TCRBV members in seroconverting patients pretreated with TDF, while BV12, BV15, and BV22 were predominant in non-seroconverting patients during TDF treatment. Taken together, the preferential TCRBV patterns may be associated with immune responses related to SC. The dynamic frequency and skewed TCRBV patterns of peripheral Tregs could contribute to predicting SC in CHB patients. Moreover, the conserved TCRBV complementarity-determining region (CDR3) motif may be targeted to develop personalized immunotherapy for CHB patients. PMID:26899927

  6. Early Skewed Distribution of Total and HIV-Specific CD8+ T-Cell Memory Phenotypes during Primary HIV Infection Is Related to Reduced Antiviral Activity and Faster Disease Progression

    PubMed Central

    Ghiglione, Yanina; Falivene, Juliana; Ruiz, María Julia; Laufer, Natalia; Socías, María Eugenia; Cahn, Pedro; Giavedoni, Luis; Sued, Omar; Gherardi, María Magdalena; Salomón, Horacio; Turk, Gabriela

    2014-01-01

    The important role of the CD8+ T-cells on HIV control is well established. However, correlates of immune protection remain elusive. Although the importance of CD8+ T-cell specificity and functionality in virus control has been underscored, further unraveling the link between CD8+ T-cell differentiation and viral control is needed. Here, an immunophenotypic analysis (in terms of memory markers and Programmed cell death 1 (PD-1) expression) of the CD8+ T-cell subset found in primary HIV infection (PHI) was performed. The aim was to seek for associations with functional properties of the CD8+ T-cell subsets, viral control and subsequent disease progression. Also, results were compared with samples from Chronics and Elite Controllers. It was found that normal maturation of total and HIV-specific CD8+ T-cells into memory subsets is skewed in PHI, but not at the dramatic level observed in Chronics. Within the HIV-specific compartment, this alteration was evidenced by an accumulation of effector memory CD8+ T (TEM) cells over fully differentiated terminal effector CD8+ T (TTE) cells. Furthermore, higher proportions of total and HIV-specific CD8+ TEM cells and higher HIV-specific TEM/(TEM+TTE) ratio correlated with markers of faster progression. Analysis of PD-1 expression on total and HIV-specific CD8+ T-cells from PHI subjects revealed not only an association with disease progression but also with skewed memory CD8+ T-cell differentiation. Most notably, significant direct correlations were obtained between the functional capacity of CD8+ T-cells to inhibit viral replication in vitro with higher proportions of fully-differentiated HIV-specific CD8+ TTE cells, both at baseline and at 12 months post-infection. Thus, a relationship between preservation of CD8+ T-cell differentiation pathway and cell functionality was established. This report presents evidence concerning the link among CD8+ T-cell function, phenotype and virus control, hence supporting the instauration of

  7. Early skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progression.

    PubMed

    Ghiglione, Yanina; Falivene, Juliana; Ruiz, María Julia; Laufer, Natalia; Socías, María Eugenia; Cahn, Pedro; Giavedoni, Luis; Sued, Omar; Gherardi, María Magdalena; Salomón, Horacio; Turk, Gabriela

    2014-01-01

    The important role of the CD8+ T-cells on HIV control is well established. However, correlates of immune protection remain elusive. Although the importance of CD8+ T-cell specificity and functionality in virus control has been underscored, further unraveling the link between CD8+ T-cell differentiation and viral control is needed. Here, an immunophenotypic analysis (in terms of memory markers and Programmed cell death 1 (PD-1) expression) of the CD8+ T-cell subset found in primary HIV infection (PHI) was performed. The aim was to seek for associations with functional properties of the CD8+ T-cell subsets, viral control and subsequent disease progression. Also, results were compared with samples from Chronics and Elite Controllers. It was found that normal maturation of total and HIV-specific CD8+ T-cells into memory subsets is skewed in PHI, but not at the dramatic level observed in Chronics. Within the HIV-specific compartment, this alteration was evidenced by an accumulation of effector memory CD8+ T (TEM) cells over fully differentiated terminal effector CD8+ T (TTE) cells. Furthermore, higher proportions of total and HIV-specific CD8+ TEM cells and higher HIV-specific TEM/(TEM+TTE) ratio correlated with markers of faster progression. Analysis of PD-1 expression on total and HIV-specific CD8+ T-cells from PHI subjects revealed not only an association with disease progression but also with skewed memory CD8+ T-cell differentiation. Most notably, significant direct correlations were obtained between the functional capacity of CD8+ T-cells to inhibit viral replication in vitro with higher proportions of fully-differentiated HIV-specific CD8+ TTE cells, both at baseline and at 12 months post-infection. Thus, a relationship between preservation of CD8+ T-cell differentiation pathway and cell functionality was established. This report presents evidence concerning the link among CD8+ T-cell function, phenotype and virus control, hence supporting the instauration of

  8. Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2b.

    PubMed

    Ackerman, Margaret E; Dugast, Anne-Sophie; McAndrew, Elizabeth G; Tsoukas, Stephen; Licht, Anna F; Irvine, Darrell J; Alter, Galit

    2013-05-01

    While development of an HIV vaccine that can induce neutralizing antibodies remains a priority, decades of research have proven that this is a daunting task. However, accumulating evidence suggests that antibodies with the capacity to harness innate immunity may provide some protection. While significant research has focused on the cytolytic properties of antibodies in acquisition and control, less is known about the role of additional effector functions. In this study, we investigated antibody-dependent phagocytosis of HIV immune complexes, and we observed significant differences in the ability of antibodies from infected subjects to mediate this critical effector function. We observed both quantitative differences in the capacity of antibodies to drive phagocytosis and qualitative differences in their FcγR usage profile. We demonstrate that antibodies from controllers and untreated progressors exhibit increased phagocytic activity, altered Fc domain glycosylation, and skewed interactions with FcγR2a and FcγR2b in both bulk plasma and HIV-specific IgG. While increased phagocytic activity may directly influence immune activation via clearance of inflammatory immune complexes, it is also plausible that Fc receptor usage patterns may regulate the immune response by modulating downstream signals following phagocytosis--driving passive degradation of internalized virus, release of immune modulating cytokines and chemokines, or priming of a more effective adaptive immune response.

  9. Nicotine can skew the characterization of the macrophage type-1 (M{Phi}1) phenotype differentiated with granulocyte-macrophage colony-stimulating factor to the M{Phi}2 phenotype

    SciTech Connect

    Yanagita, Manabu; Kobayashi, Ryohei; Murakami, Shinya

    2009-10-09

    Macrophages (M{Phi}s) exhibit functional heterogeneity and plasticity in the local microenvironment. Recently, it was reported that M{Phi}s can be divided into proinflammatory M{Phi}s (M{Phi}1) and anti-inflammatory M{Phi}s (M{Phi}2) based on their polarized functional properties. Here, we report that nicotine, the major ingredient of cigarette smoke, can modulate the characteristics of M{Phi}1. Granulocyte-macrophage colony-stimulating factor-driven M{Phi}1 with nicotine (Ni-M{Phi}1) showed the phenotypic characteristics of M{Phi}2. Like M{Phi}2, Ni-M{Phi}1 exhibited antigen-uptake activities. Ni-M{Phi}1 suppressed IL-12, but maintained IL-10 and produced high amounts of MCP-1 upon lipopolysaccharide stimulation compared with M{Phi}1. Moreover, we observed strong proliferative responses of T cells to lipopolysaccharide-stimulated M{Phi}1, whereas Ni-M{Phi}1 reduced T cell proliferation and inhibited IFN-{gamma} production by T cells. These results suggest that nicotine can change the functional characteristics of M{Phi} and skew the M{Phi}1 phenotype to M{Phi}2. We propose that nicotine is a potent regulator that modulates immune responses in microenvironments.

  10. Correlation between clinical severity in patients with Rett syndrome with a p.R168X or p.T158M MECP2 mutation, and the direction and degree of skewing of X‐chromosome inactivation

    PubMed Central

    Archer, Hayley; Evans, Julie; Leonard, Helen; Colvin, Lyn; Ravine, David; Christodoulou, John; Williamson, Sarah; Charman, Tony; Bailey, Mark E S; Sampson, Julian; de Klerk, Nicholas; Clarke, Angus

    2007-01-01

    Introduction Rett syndrome (RTT) is an X‐linked dominant neurodevelopmental disorder that is usually associated with mutations in the MECP2 gene. The most common mutations in the gene are p.R168X and p.T158M. The influence of X‐chromosome inactivation (XCI) on clinical severity in patients with RTT with these mutations was investigated, taking into account the extent and direction of skewing. Methods Female patients and their parents were recruited from the UK and Australia. Clinical severity was measured by the Pineda Severity and Kerr profile scores. The degree of XCI and its direction relative to the X chromosome parent of origin were measured in DNA prepared from peripheral blood leucocytes, and allele‐specific polymerase chain reaction was used to determine the parental origin of mutation. Combining these, the percentage of cells expected to express the mutant allele was calculated. Results Linear regression analysis was undertaken for fully informative cases with p.R168X (n = 23) and p.T158M (n = 20) mutations. A statistically significant increase in clinical severity with increase in the proportion of active mutated allele was shown for both the p.R168X and p.T158M mutations. Conclusions XCI may vary in neurological and haematological tissues. However, these data are the first to show a relationship between the degree and direction of XCI in leucocytes and clinical severity in RTT, although the clinical utility of this in giving a prognosis for individual patients is unclear. PMID:16905679

  11. Fluid flow in a skewed annulus

    SciTech Connect

    Haci, M.; Cartalos, U.

    1996-06-01

    A novel, realistic treatment of annular flow in an oil well is developed. The fluid flow in an annulus with an inclined or S-shaped inner pipe is considered. The model covers laminar and turbulent flow regimes and the results are experimentally verified. The study predicts axial and angular velocities and frictional pressure losses. The frictional pressure losses are shown to be higher than in the corresponding concentric annulus when the inner pipe is severely S-shaped. However, for typical drilling well geometries, the frictional pressure losses are found to approach the eccentric annular predictions asymptotically. Thus, the study finds the average eccentricity of a vertical or near vertical well, which is a difficult parameter for the engineer to estimate. The results of the study are of practical importance where high annular frictional pressure losses are encountered, such as in slim holes and coiled tubing operations. The frictional pressure losses in complex annular geometries are presented in an easily usable form.

  12. Experimental Persistent Infection of BALB/c Mice with Small-Colony Variants of Burkholderia pseudomallei Leads to Concurrent Upregulation of PD-1 on T Cells and Skewed Th1 and Th17 Responses

    PubMed Central

    See, Jia-Xiang; Samudi, Chandramathi; Saeidi, Alireza; Menon, Nivedita; Choh, Leang-Chung; Vadivelu, Jamuna; Shankar, Esaki M.

    2016-01-01

    Background Burkholderia pseudomallei (B. pseudomallei), the causative agent of melioidosis, is a deadly pathogen endemic across parts of tropical South East Asia and Northern Australia. B. pseudomallei can remain latent within the intracellular compartment of the host cell over prolonged periods of time, and cause persistent disease leading to treatment difficulties. Understanding the immunological mechanisms behind persistent infection can result in improved treatment strategies in clinical melioidosis. Methods Ten-day LD50 was determined for the small-colony variant (SCV) and its parental wild-type (WT) via intranasal route in experimental BALB/c mice. Persistent B. pseudomallei infection was generated by administrating sub-lethal dose of the two strains based on previously determined LD50. After two months, peripheral blood mononuclear cells (PBMCs) and plasma were obtained to investigate host immune responses against persistent B. pseudomallei infection. Lungs, livers, and spleens were harvested and bacterial loads in these organs were determined. Results Based on the ten-day LD50, the SCV was ~20-fold less virulent than the WT. The SCV caused higher bacterial loads in spleens compared to its WT counterparts with persistent B. pseudomallei infection. We found that the CD4+ T-cell frequencies were decreased, and the expressions of PD-1, but not CTLA-4 were significantly increased on the CD4+ and CD8+ T cells of these mice. Notably, persistent infection with the SCV led to significantly higher levels of PD-1 than the WT B. pseudomallei. Plasma IFN-γ, IL-6, and IL-17A levels were elevated only in SCV-infected mice. In addition, skewed plasma Th1 and Th17 responses were observed in SCV-infected mice relative to WT-infected and uninfected mice. Conclusion B. pseudomallei appears to upregulate the expression of PD-1 on T cells to evade host immune responses, which likely facilitates bacterial persistence in the host. SCVs cause distinct pathology and immune

  13. B3LYP/6-311++G** study of alpha- and beta-D-glucopyranose and 1,5-anhydro-D-glucitol: 4C1 and 1C4 chairs, (3,O)B and B(3,O) boats, and skew-boat conformations.

    PubMed

    Appell, M; Strati, G; Willett, J L; Momany, F A

    2004-02-25

    Geometry optimization, at the B3LYP/6-311++G** level of theory, was carried out on 4C1 and 1C4 chairs, (3,O)B and B(3,O) boats, and skew-boat conformations of alpha- and beta-D-glucopyranose. Similar calculations on 1,5-anhydro-D-glucitol allowed examination of the effect of removal of the 1-hydroxy group on the energy preference of the hydroxymethyl rotamers. Stable minimum energy boat conformers of glucose were found, as were stable skew boats, all having energies ranging from approximately 4-15 kcal/mol above the global energy 4C1 chair conformation. The 1C4 chair electronic energies were approximately 5-10 kcal/mol higher than the 4C1 chair, with the 1C4 alpha-anomers being lower in energy than the beta-anomers. Zero-point energy, enthalpy, entropy, and relative Gibbs free energies are reported at the harmonic level of theory. The alpha-anomer 4C1 chair conformations were found to be approximately 1 kcal/mol lower in electronic energy than the beta-anomers. The hydroxymethyl gt conformation was of lowest electronic energy for both the alpha- and beta-anomers. The glucose alpha/beta anomer ratio calculated from the relative free energies is 63/37%. From a numerical Hessian calculation, the tg conformations were found to be approximately 0.4-0.7 kcal/mol higher in relative free energy than the gg or gt conformers. Transition-state barriers to rotation about the C-5-C-6 bond were calculated for each glucose anomer with resulting barriers to rotation of approximately 3.7-5.8 kcal/mol. No energy barrier was found for the path between the alpha-gt and alpha-gg B(3,O) boat forms and the equivalent 4C1 chair conformations. The alpha-tg conformation has an energy minimum in the 1S3 twist form. Other boat and skew-boat forms are described. The beta-anomer boats retained their starting conformations, with the exception of the beta-tg-(3,O)B boat that moved to a skew form upon optimization.

  14. Write-Skewed: Writing in an Introductory Statistics Course

    ERIC Educational Resources Information Center

    Delcham, Hendrick; Sezer, Renan

    2010-01-01

    Statistics is used in almost every facet of our daily lives: crime reports, election results, environmental/climate change, advances in business, financial planning, and progress in multifarious research. Although understanding statistics is essential for efficient functioning in the modern world (Cerrito 1996), students often do not grasp…

  15. Although Relatively Few, "Doctor Shoppers" Skew Opioid Prescribing

    MedlinePlus

    ... integrating prescription history data into patients’ electronic medical records. “These doctor-shopping patients are clearly different, and they are exploiting the absence of good data management right now. The best way to improve the ...

  16. Carcinoma origin dictates differential skewing of monocyte function

    PubMed Central

    Bögels, Marijn; Braster, Rens; Nijland, Philip G.; Gül, Nuray; van de Luijtgaarden, Wendy; Fijneman, Remond J.A.; Meijer, Gerrit A.; Jimenez, Connie R.; Beelen, Robert H.J.; van Egmond, Marjolein

    2012-01-01

    Macrophages are versatile cells, which phenotype is profoundly influenced by their environment. Pro-inflammatory classically activated or M1 macrophages, and anti-inflammatory alternatively-activated or M2 macrophages represent two extremes of a continuum of functional states. Consequently, macrophages that are present in tumors can exert tumor-promoting and tumor-suppressing activity, depending on the tumor milieu. In this study we investigated how human monocytes—the precursors of macrophages—are influenced by carcinoma cells of different origin. We demonstrate that monocytes, stimulated with breast cancer supernatant, showed increased expression of interleukin (IL)-10, IL-8 and chemokines CCL17 and CCL22, which are associated with an alternatively-activated phenotype. By contrast, monocytes that were cultured in supernatants of colon cancer cells produced more pro-inflammatory cytokines (e.g., IL-12 and TNFα) and reactive oxygen species. Secretome analysis revealed differential secretion of proteins by colon and breast cancer cell lines, of which the proteoglycan versican was exclusively secreted by colon carcinoma cell lines. Reducing active versican by blocking with monoclonal antibodies or shRNA diminished pro-inflammatory cytokine production by monocytes. Thus, colon carcinoma cells polarize monocytes toward a more classically-activated anti-tumorigenic phenotype, whereas breast carcinomas predispose monocytes toward an alternatively activated phenotype. Interestingly, presence of macrophages in breast or colon carcinomas correlates with poor or good prognosis in patients, respectively. The observed discrepancy in macrophage activation by either colon or breast carcinoma cells may therefore explain the dichotomy between patient prognosis and macrophage presence in these different tumors. Designing new therapies, directing development of monocytes toward M1 activated tumor macrophages in cancer patients, may have great clinical benefits. PMID:23162747

  17. Incubation temperature causes skewed sex ratios in a precocial bird.

    PubMed

    DuRant, Sarah E; Hopkins, William A; Carter, Amanda W; Kirkpatrick, Laila T; Navara, Kristin J; Hawley, Dana M

    2016-07-01

    Many animals with genetic sex determination are nonetheless capable of manipulating sex ratios via behavioral and physiological means, which can sometimes result in fitness benefits to the parent. Sex ratio manipulation in birds is not widely documented, and revealing the mechanisms for altered sex ratios in vertebrates remains a compelling area of research. Incubation temperature is a key component of the developmental environment for birds, but despite its well-documented effects on offspring phenotype it has rarely been considered as a factor in avian sex ratios. Using ecologically relevant manipulations of incubation temperature within the range 35.0-37.0°C, we found greater mortality of female embryos during incubation than males regardless of incubation temperature, and evidence that more female than male embryos die at the lowest incubation temperature (35.0°C). Our findings in conjunction with previous work in brush turkeys suggest incubation temperature is an important determinant of avian secondary sex ratios that requires additional study, and should be considered when estimating the impact of climate change on avian populations. PMID:27143750

  18. Skewed Sex Ratios and Criminal Victimization in India

    PubMed Central

    South, Scott J.; Trent, Katherine; Bose, Sunita

    2014-01-01

    Although substantial research has explored the causes of India’s excessively masculine population sex ratio, few studies have examined the consequences of this surplus of males. We merge individual-level data from the 2004–2005 India Human Development Survey with data from the 2001 India population census to examine the association between the district-level male-to-female sex ratio at ages 15 to 39 and self-reports of victimization by theft, breaking and entering, and assault. Multilevel logistic regression analyses reveal positive and statistically significant albeit substantively modest effects of the district-level sex ratio on all three victimization risks. We also find that higher male-to-female sex ratios are associated with the perception that young unmarried women in the local community are frequently harassed. Household-level indicators of family structure, socioeconomic status, and caste, as well as areal indicators of women’s empowerment and collective efficacy, also emerge as significant predictors of self-reported criminal victimization and the perceived harassment of young women. The implications of these findings for India’s growing sex ratio imbalance are discussed. PMID:24682921

  19. The gestural misinformation effect: skewing eyewitness testimony through gesture.

    PubMed

    Gurney, Daniel J; Pine, Karen J; Wiseman, Richard

    2013-01-01

    The susceptibility of eyewitnesses to verbal suggestion has been well documented, although little attention has been paid to the role of nonverbal communication in misinformation. Three experiments are reported; in each, participants watched footage of a crime scene before being questioned about what they had observed. In Experiments 1 and 2, an on-screen interviewer accompanied identically worded questions with gestures that either conveyed accurate information about the scene or conveyed false, misleading information. The misleading gestures significantly influenced recall, and participants' responses were consistent with the gestured information. In Experiment 3, a live interview was conducted, and the gestural misinformation effect was found to be robust; participants were influenced by misleading gestures performed by the interviewer during questioning. These findings provide compelling evidence for the gestural misinformation effect, whereby subtle hand gestures can implant information and distort the testimony of eyewitnesses. The practical and legal implications of these findings are discussed. PMID:24027944

  20. Skewness for Maximum Likelihood Estimators of the Negative Binomial Distribution

    SciTech Connect

    Bowman, Kimiko o

    2007-01-01

    The probability generating function of one version of the negative binomial distribution being (p + 1 - pt){sup -k}, we study elements of the Hessian and in particular Fisher's discovery of a series form for the variance of k, the maximum likelihood estimator, and also for the determinant of the Hessian. There is a link with the Psi function and its derivatives. Basic algebra is excessively complicated and a Maple code implementation is an important task in the solution process. Low order maximum likelihood moments are given and also Fisher's examples relating to data associated with ticks on sheep. Efficiency of moment estimators is mentioned, including the concept of joint efficiency. In an Addendum we give an interesting formula for the difference of two Psi functions.

  1. Evaluating the performance of skewed prestressed concrete bridge after strengthening

    NASA Astrophysics Data System (ADS)

    Naser, Ali Fadhil; Zonglin, Wang

    2013-06-01

    The objectives of this paper are to explain the application of repairing and strengthening methods on the damaged members of the bridge structure, to analyze the static and dynamic structural response under static and dynamic loads after strengthening, and to evaluate the structural performance after application of strengthening method. The repairing and strengthening methods which are used in this study include treatment of the cracks, thickening the web of box girder along the bridge length and adding internal pre-stressing tendons in the thickening web, and construct reinforced concrete cross beams (diaphragms) between two box girders. The results of theoretical analysis of static and dynamic structural responses after strengthening show that the tensile stresses are decreased and become less than the allowable limit values in the codes. The values of vertical deflection are decreased after strengthening. The values of natural frequencies after strengthening are increased, indicating that the strengthening method is effective to reduce the vibration of the bridge structure. Therefore, the strengthening methods are effective to improve the bearing capacity and elastic working state of the bridge structure and to increase the service life of the bridge structure.

  2. Extracellular HSP110 skews macrophage polarization in colorectal cancer.

    PubMed

    Berthenet, Kevin; Boudesco, Christophe; Collura, Ada; Svrcek, Magali; Richaud, Sarah; Hammann, Arlette; Causse, Sebastien; Yousfi, Nadhir; Wanherdrick, Kristell; Duplomb, Laurence; Duval, Alex; Garrido, Carmen; Jego, Gaetan

    2016-07-01

    HSP110 is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps the cells to survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently showed that colorectal cancer (CRC) patients with microsatellite instability (MSI) had an improved response to chemotherapy because they harbor an HSP110 inactivating mutation (HSP110DE9). In this work, we have used patients' biopsies and human CRC cells grown in vitro and in vivo (xenografts) to demonstrate that (1) HSP110 is secreted by CRC cells and that the amount of this extracellular HSP110 is strongly decreased by the expression of the mutant HSP110DE9, (2) Supernatants from CRC cells overexpressing HSP110 or purified recombinant human HSP110 (LPS-free) affect macrophage differentiation/polarization by favoring a pro-tumor, anti-inflammatory profile, (3) Conversely, inhibition of HSP110 (expression of siRNA, HSP110DE9 or immunodepletion) induced the formation of macrophages with a cytotoxic, pro-inflammatory profile. (4) Finally, this effect of extracellular HSP110 on macrophages seems to implicate TLR4. These results together with the fact that colorectal tumor biopsies with HSP110 high were infiltrated with macrophages with a pro-tumoral profile while those with HSP110 low were infiltrated with macrophages with a cytotoxic profile, suggest that the effect of extracellular HSP110 function on macrophages may also contribute to the poor outcomes associated with HSP110 expression. PMID:27622020

  3. Schroedinger uncertainty relation with Wigner-Yanase skew information

    SciTech Connect

    Furuichi, Shigeru

    2010-09-15

    We shall give an alternative Schroedinger-type uncertainty relation for a quantity representing a quantum uncertainty, introduced by Luo [Phys. Rev. A 72, 042110 (2005)]. Our result improves the Heisenberg-type uncertainty relation shown in Luo's paper for a mixed state.

  4. The Heteroscedastic Graded Response Model with a Skewed Latent Trait: Testing Statistical and Substantive Hypotheses Related to Skewed Item Category Functions

    ERIC Educational Resources Information Center

    Molenaar, Dylan; Dolan, Conor V.; de Boeck, Paul

    2012-01-01

    The Graded Response Model (GRM; Samejima, "Estimation of ability using a response pattern of graded scores," Psychometric Monograph No. 17, Richmond, VA: The Psychometric Society, 1969) can be derived by assuming a linear regression of a continuous variable, Z, on the trait, [theta], to underlie the ordinal item scores (Takane & de Leeuw in…

  5. Heat transfer in rotating serpentine passages with selected model orientation for smooth or skewed trip walls

    NASA Astrophysics Data System (ADS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1993-04-01

    Experiments were conducted to determine the effects of model orientation as well as buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. Turbine blades have internal coolant passage surfaces at the leading and trailing edges of the airfoil with surfaces at angles which are as large as +/- 50 to 60 degrees to the axis of rotation. Most of the previously-presented, multiple-passage, rotating heat transfer experiments have focused on radial passages aligned with the axis of rotation. Results from serpentine passages with orientations 0 and 45 degrees to the axis of rotation which simulate the coolant passages for the mid chord and trailing edge regions of the rotating airfoil are compared. The experiments were conducted with rotation in both directions to simulate serpentine coolant passages with the rearward flow of coolant or with the forward flow of coolant. The experiments were conducted for passages with smooth surfaces and with 45 degree trips adjacent to airfoil surfaces for the radial portion of the serpentine passages. At a typical flow condition, the heat transfer on the leading surfaces for flow outward in the first passage with smooth walls was twice as much for the model at 45 degrees compared to the model at 0 degrees. However, the differences for the other passages and with trips were less. In addition, the effects of buoyancy and Coriolis forces on heat transfer in the rotating passage were decreased with the model at 45 degrees, compared to the results at 0 degrees. The heat transfer in the turn regions and immediately downstream of the turns in the second passage with flow inward and in the third passage with flow outward was also a function of model orientation with differences as large as 40 to 50 percent occurring between the model orientations with forward flow and rearward flow of coolant.

  6. Skewed probability densities in the ring laser gyroscope: A colored noise effect

    SciTech Connect

    Vogel, K.; Risken, H.; Schleich, W.; James, M.; Moss, F.; McClintock, P.V.E.

    1987-01-01

    The influence of noise color on the phase diffusion in a ring-laser gyroscope is studied by use of a (formally) exact solution of the time-independent Fokker-Planck equation. Novel asymmetries in the distribution which develop with increasing noise correlation time are predicted and verified with an electronic model of the corresponding Langevin equation.

  7. Is mate choice copying or aggregation responsible for skewed distributions of females on leks?

    PubMed

    McComb, K; Clutton-Brock, T

    1994-01-22

    In several lek-breeding populations of birds and mammals, females arriving on leks tend to join males that already have females in their territories. This might occur either because females have an evolved preference for mating with males that are attractive to other females, or because they join groups of other females to obtain greater safety from predation or dangerous harassment by males. We have previously used controlled experiments to show that oestrous fallow deer females join males with established harems because they are attracted to female groups rather than to the males themselves. Here we demonstrate that the preference for males with females over males without females is specific to oestrous females and weak or absent in anoestrous ones, and that it is not associated with a preference for mating with males that have previously been seen to mate with other females. Furthermore, oestrous females given the choice between males that do not already have females with them show no significant preference for antlered over deantlered males or for older males over younger ones. We conclude that female attraction to other females on the lek is likely to be an adaptation to avoiding harassment in mixed-sex herds. In this situation, a male's ability to maintain the cohesion of his harem may be the principal cause of variation in mating success between males.

  8. Confidence Intervals for True Scores Using the Skew-Normal Distribution

    ERIC Educational Resources Information Center

    Garcia-Perez, Miguel A.

    2010-01-01

    A recent comparative analysis of alternative interval estimation approaches and procedures has shown that confidence intervals (CIs) for true raw scores determined with the Score method--which uses the normal approximation to the binomial distribution--have actual coverage probabilities that are closest to their nominal level. It has also recently…

  9. Skewed sex ratios at birth and future marriage squeeze in China and India, 2005-2100.

    PubMed

    Guilmoto, Christophe Z

    2012-02-01

    I examine the potential impact of the anticipated future marriage squeeze on nuptiality patterns in China and India during the twenty-first century. I use population projections from 2005 to 2100 based on three different scenarios for the sex ratio at birth (SRB). To counteract the limitations of cross-sectional methods commonly used to assess the severity of marriage squeezes, I use a two-sex cohort-based procedure to simulate marriage patterns over the twenty-first century based on the female dominance model. I also examine two more-flexible marriage functions to illustrate the potential impact of changes in marriage schedules as a response to the marriage squeeze. Longitudinal indicators of marriage squeeze indicate that the number of prospective grooms in both countries will exceed that of prospective brides by more 50% for three decades in the most favorable scenario. Rates of male bachelorhood will not peak before 2050, and the squeeze conditions will be felt several decades thereafter, even among cohorts unaffected by adverse SRB. If the SRB is allowed to return to normalcy by 2020, the proportion of men unmarried at age 50 is expected to rise to 15% in China by 2055 and to 10% in India by 2065. India suffers from the additional impact of a delayed fertility transition on its age structures.

  10. Dynamics of mean-variance-skewness of cumulative crop yield impact temporal yield variance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Production risk associated with cropping systems influences farmers’ decisions to adopt a new management practice or a production system. Cumulative yield (CY), temporal yield variance (TYV) and coefficient of variation (CV) were used to assess the risk associated with adopting combinations of new m...

  11. Biased gene conversion skews allele frequencies in human populations, increasing the disease burden of recessive alleles.

    PubMed

    Lachance, Joseph; Tishkoff, Sarah A

    2014-10-01

    Gene conversion results in the nonreciprocal transfer of genetic information between two recombining sequences, and there is evidence that this process is biased toward G and C alleles. However, the strength of GC-biased gene conversion (gBGC) in human populations and its effects on hereditary disease have yet to be assessed on a genomic scale. Using high-coverage whole-genome sequences of African hunter-gatherers, agricultural populations, and primate outgroups, we quantified the effects of GC-biased gene conversion on population genomic data sets. We find that genetic distances (FST and population branch statistics) are modified by gBGC. In addition, the site frequency spectrum is left-shifted when ancestral alleles are favored by gBGC and right-shifted when derived alleles are favored by gBGC. Allele frequency shifts due to gBGC mimic the effects of natural selection. As expected, these effects are strongest in high-recombination regions of the human genome. By comparing the relative rates of fixation of unbiased and biased sites, the strength of gene conversion was estimated to be on the order of Nb ≈ 0.05 to 0.09. We also find that derived alleles favored by gBGC are much more likely to be homozygous than derived alleles at unbiased SNPs (+42.2% to 62.8%). This results in a curse of the converted, whereby gBGC causes substantial increases in hereditary disease risks. Taken together, our findings reveal that GC-biased gene conversion has important population genetic and public health implications.

  12. CD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging.

    PubMed

    Tang, Qianqiao; Koh, Liang Kai; Jiang, Dongsheng; Schwarz, Herbert

    2013-09-01

    CD137 is a costimulatory molecule expressed on activated T cells. Its ligand, CD137L, is expressed on the surface of hematopoietic progenitor cells, and upon binding to CD137 induces reverse signaling into hematopoietic progenitor cells promoting their activation, proliferation and myeloid differentiation. Since aging is associated with an increasing number of myeloid cells we investigated the role of CD137 and CD137L on myelopoiesis during aging. Comparing 3 and 12 months old WT, CD137‐/‐ and CD137L‐/‐ mice we found significantly more granulocytes and monocytes in the bone marrow of older WT mice, while this age‐dependent increase was absent in CD137‐/‐ and CD137L‐/‐ mice. Instead, the bone marrow of 12 months old CD137‐/‐ and CD137L‐/‐ mice was characterized by an accumulation of hematopoietic progenitor cells, suggesting that the differentiation of hematopoietic progenitor cells became arrested in the absence of CD137L signaling. CD137L signaling is initiated by activated CD137‐expressing, CD4+ T cells. These data identify a novel molecular mechanisms underlying immune aging by demonstrating that CD137‐expressing CD4+ T cells in the bone marrow engage CD137L on hematopoietic progenitor cells, and that this CD137L signaling biases hematopoiesis towards myelopoiesis during aging.

  13. Descriptive Statistics for Modern Test Score Distributions: Skewness, Kurtosis, Discreteness, and Ceiling Effects

    ERIC Educational Resources Information Center

    Ho, Andrew D.; Yu, Carol C.

    2015-01-01

    Many statistical analyses benefit from the assumption that unconditional or conditional distributions are continuous and normal. More than 50 years ago in this journal, Lord and Cook chronicled departures from normality in educational tests, and Micerri similarly showed that the normality assumption is met rarely in educational and psychological…

  14. Divorce and infidelity are associated with skewed adult sex ratios in birds.

    PubMed

    Liker, András; Freckleton, Robert P; Székely, Tamás

    2014-04-14

    Adult sex ratio (ASR) is a fundamental concept in population demography, and recent theory suggests that ASR plays a central role in social behavior, mating systems, and parental care. Unbalanced ASRs are predicted to influence pair-bond and mating behavior, since the rarer sex in the population has more potential partners to mate with than the more common sex. Here we use phylogenetic comparative analyses to test whether ASR is related to three major aspects of mating behavior: divorce, social polygamy, and pair-bond infidelity. ASR is strongly correlated with long-term pair bonds, since the divorce rate is higher in species with a female-biased sex ratio, indicating that mate change by pair members and/or breaking of pair bonds by unmated individuals is more frequent when females outnumber males. Short-term pair bonds are also associated with unbalanced ASRs: males are more commonly polygamous when females outnumber males, and conversely, females are more polygamous when males outnumber females. Furthermore, infidelity increases with male-biased ASR in socially monogamous birds, suggesting that male coercion and/or female willingness to cheat the partner are facilitated by male-biased ASR. Our results provide the first comprehensive support for the proposition that ASR influences multiple aspects of pair-bond and mating behavior in wild populations. PMID:24656831

  15. Skewed Riskscapes and Environmental Injustice: A Case Study of Metropolitan St. Louis

    NASA Astrophysics Data System (ADS)

    Abel, Troy D.

    2008-08-01

    This article presents a case study of Toxics Release Inventory (TRI) air pollution exposure risks across metropolitan St. Louis. The first section critically reviews environmental justice research and related barriers to environmental risk management. Second, the paper offers a conventional analysis of the spatial patterns of TRI facilities and their surrounding census block group demographics for metropolitan St. Louis. Third, the article describes the use of an exposure risk characterization for 319 manufacturers and their air releases of more than 126 toxic pollutants. This information could lead to more practical resolutions of urban environmental injustices. The analysis of TRIs across metropolitan St. Louis shows that minority and low-income residents were disproportionately closer to industrial pollution sources at nonrandom significance levels. Spatial concentrations of minority residents averaged nearly 40% within one kilometer of St. Louis TRI sites compared to 25% elsewhere. However, one-fifth of the region’s air pollution exposure risk over a decade was spatially concentrated among only six facilities on the southwestern border of East St. Louis. This disproportionate concentration of some of the greatest pollution risk would never be considered in most conventional environmental justice analyses. Not all pollution exposure risk is average, and the worst risks deserve more attention from environmental managers assessing and mitigating environmental injustices.

  16. Skewed riskscapes and environmental injustice: a case study of metropolitan St. Louis.

    PubMed

    Abel, Troy D

    2008-08-01

    This article presents a case study of Toxics Release Inventory (TRI) air pollution exposure risks across metropolitan St. Louis. The first section critically reviews environmental justice research and related barriers to environmental risk management. Second, the paper offers a conventional analysis of the spatial patterns of TRI facilities and their surrounding census block group demographics for metropolitan St. Louis. Third, the article describes the use of an exposure risk characterization for 319 manufacturers and their air releases of more than 126 toxic pollutants. This information could lead to more practical resolutions of urban environmental injustices. The analysis of TRIs across metropolitan St. Louis shows that minority and low-income residents were disproportionately closer to industrial pollution sources at nonrandom significance levels. Spatial concentrations of minority residents averaged nearly 40% within one kilometer of St. Louis TRI sites compared to 25% elsewhere. However, one-fifth of the region's air pollution exposure risk over a decade was spatially concentrated among only six facilities on the southwestern border of East St. Louis. This disproportionate concentration of some of the greatest pollution risk would never be considered in most conventional environmental justice analyses. Not all pollution exposure risk is average, and the worst risks deserve more attention from environmental managers assessing and mitigating environmental injustices.

  17. Male dominance rarely skews the frequency distribution of Y chromosome haplotypes in human populations

    PubMed Central

    Lansing, J. Stephen; Watkins, Joseph C.; Hallmark, Brian; Cox, Murray P.; Karafet, Tatiana M.; Sudoyo, Herawati; Hammer, Michael F.

    2008-01-01

    A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects that are subject to cultural selection. However, evidence for such selection is inconclusive because it is based on short-term statistical associations between behavior and fertility. Here, we show that the evolutionary effects of dominance at the population level can be detected using noncoding regions of DNA. Highly variable polymorphisms on the nonrecombining portion of the Y chromosome can be used to trace lines of descent from a common male ancestor. Thus, it is possible to test for the persistence of differential fertility among patrilines. We examine haplotype distributions defined by 12 short tandem repeats in a sample of 1269 men from 41 Indonesian communities and test for departures from neutral mutation-drift equilibrium based on the Ewens sampling formula. Our tests reject the neutral model in only 5 communities. Analysis and simulations show that we have sufficient power to detect such departures under varying demographic conditions, including founder effects, bottlenecks, and migration, and at varying levels of social dominance. We conclude that patrilines seldom are dominant for more than a few generations, and thus traits or behaviors that are strictly paternally inherited are unlikely to be under strong cultural selection. PMID:18703660

  18. Southern Hemisphere climate trends skewed by coarse temporal resolution of specified stratospheric ozone

    NASA Astrophysics Data System (ADS)

    Neely, R. R., III; Marsh, D. R.; Smith, K. L.; Davis, S. M.; Polvani, L. M.

    2014-12-01

    Global climate models that do not include interactive middle atmosphere chemistry, such as those contributing to the Coupled Model Intercomparison Project Phase 5, typically specify stratospheric ozone using monthly-mean zonal-mean values. Here we show that such coarse temporal resolution leads to significant biases in the simulated climate of the Southern Hemisphere (SH) over the late twentieth century. This is demonstrated using the Whole Atmosphere Community Climate Model in simulations with and without interactive chemistry. Previous studies have attributed similar differences in SH climate change simulations to biases created by the spatial smoothing of specified ozone, i.e., due to prescribing zonal-mean concentrations. We isolate the impact of undersampling the rapid temporal changes in ozone during the seasonal evolution of the Antarctic ozone hole from the impact of prescribing zonal-means, and show that temporal resolution of prescribed ozone is of equal importance to zonal asymmetries.

  19. Shared prefetching to reduce execution skew in multi-threaded systems

    DOEpatents

    Eichenberger, Alexandre E; Gunnels, John A

    2013-07-16

    Mechanisms are provided for optimizing code to perform prefetching of data into a shared memory of a computing device that is shared by a plurality of threads that execute on the computing device. A memory stream of a portion of code that is shared by the plurality of threads is identified. A set of prefetch instructions is distributed across the plurality of threads. Prefetch instructions are inserted into the instruction sequences of the plurality of threads such that each instruction sequence has a separate sub-portion of the set of prefetch instructions, thereby generating optimized code. Executable code is generated based on the optimized code and stored in a storage device. The executable code, when executed, performs the prefetches associated with the distributed set of prefetch instructions in a shared manner across the plurality of threads.

  20. Skewed distribution of hypothyroidism in the coastal communities of Newfoundland, Canada.

    PubMed

    Sarkar, Atanu; Knight, John C; Babichuk, Nicole A; Mulay, Shree

    2015-10-01

    Several studies published in the recent past have shown that rising levels of thyroid disrupting chemicals (TDCs) in the environment affect thyroid function in humans. These TDCs are the anthropogenic organic compounds that enter the human body mostly by ingestion and may trigger autoimmune thyroiditis, the most common cause of hypothyroidism. The studies also show the presence of high levels of TDCs in marine animals; therefore, consumption of contaminated seafood might trigger hypothyroidism. So far, there is no readily available population-based data, showing the regional distribution of hypothyroidism cases. We collected administrative data from the Newfoundland and Labrador Centre for Health Information on hospitalizations with hypothyroidism (from 1998 to 2012) in 41 coastal communities of Newfoundland and found that mean hypothyroidism rates of west and south coasts were significantly higher than in the east coast (1.8 and 1.9 times respectively). A one-way analysis of variance was used to test for regional differences in rates. A significant between-group difference in the rate of hypothyroidism was found (F2,38 = 8.309; p = 0.001). The St. Lawrence River, its estuary and the Gulf of St. Lawrence are heavily polluted with TDCs from industries, their effluents, and urbanization in the Great Lakes Watershed and along the river. Environment Canada has already identified this river along with the Great Lakes Watershed as one of the top TDCs polluted water sources in the country. The west and south coasts are in contact with the Gulf of St. Lawrence. Local marine products are a regular diet of the coastal communities of Newfoundland. Based on these available evidence, we hypothesize the role of TDCs in the rise of hypothyroidism on the western and southern coasts. However, further study will be needed to establish any association between abnormally high rates of hypothyroidism and exposure to TDCs.

  1. Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo

    PubMed Central

    Amoyel, Marc; Simons, Benjamin D; Bach, Erika A

    2014-01-01

    Neutral competition, an emerging feature of stem cell homeostasis, posits that individual stem cells can be lost and replaced by their neighbors stochastically, resulting in chance dominance of a clone at the niche. A single stem cell with an oncogenic mutation could bias this process and clonally spread the mutation throughout the stem cell pool. The Drosophila testis provides an ideal system for testing this model. The niche supports two stem cell populations that compete for niche occupancy. Here, we show that cyst stem cells (CySCs) conform to the paradigm of neutral competition and that clonal deregulation of either the Hedgehog (Hh) or Hippo (Hpo) pathway allows a single CySC to colonize the niche. We find that the driving force behind such behavior is accelerated proliferation. Our results demonstrate that a single stem cell colonizes its niche through oncogenic mutation by co-opting an underlying homeostatic process. PMID:25092766

  2. Effects of Mass and Volume Fraction Skewness in Variable Density Mixing Processes

    NASA Astrophysics Data System (ADS)

    Wachtor, Adam J.; Bakosi, Jozsef; Ristorcelli, Raymond

    2015-11-01

    Among the parameters characterizing mixing by variable density turbulence of fluids involving density variations of a factor of 5 to 10 are the Atwood, Froude, Schmidt, and Reynolds numbers. There is evidence that the amount of each fluid present when the two pure fluids mix, as described by the probability density function of the mass or molar (volume) fraction, also strongly affects the mixing process. To investigate this phenomena, implicit large-eddy simulations (ILES) are performed for binary fluid mixtures in statistically homogenous environments under constant acceleration. These coarse grained simulations are used as data for theory validation and mix model development. ILES has been demonstrated to accurately capture the mixing behavior of a passive scalar field through stirring and advection by a turbulent velocity field. The present work advances that research and studies the extent to which an under-resolved active scalar drives the subsequent fluid motion and determines the nature of the mixing process. Effects of initial distributions of the mass and molar (volume) fraction probability density function on the resulting variable density turbulence and mixing are investigated and compared to direct numerical simulations from the Johns Hopkins Turbulence Database. Funded by the LANL LDRD-ER on ``Inserting Nonlinear N-Material Coupling PDF Information into Turbulent Mixing Models'' through exploratory research project number 20150498ER.

  3. Heat transfer in rotating serpentine passages with selected model orientation for smooth or skewed trip walls

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1993-01-01

    Experiments were conducted to determine the effects of model orientation as well as buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. Turbine blades have internal coolant passage surfaces at the leading and trailing edges of the airfoil with surfaces at angles which are as large as +/- 50 to 60 degrees to the axis of rotation. Most of the previously-presented, multiple-passage, rotating heat transfer experiments have focused on radial passages aligned with the axis of rotation. Results from serpentine passages with orientations 0 and 45 degrees to the axis of rotation which simulate the coolant passages for the mid chord and trailing edge regions of the rotating airfoil are compared. The experiments were conducted with rotation in both directions to simulate serpentine coolant passages with the rearward flow of coolant or with the forward flow of coolant. The experiments were conducted for passages with smooth surfaces and with 45 degree trips adjacent to airfoil surfaces for the radial portion of the serpentine passages. At a typical flow condition, the heat transfer on the leading surfaces for flow outward in the first passage with smooth walls was twice as much for the model at 45 degrees compared to the model at 0 degrees. However, the differences for the other passages and with trips were less. In addition, the effects of buoyancy and Coriolis forces on heat transfer in the rotating passage were decreased with the model at 45 degrees, compared to the results at 0 degrees. The heat transfer in the turn regions and immediately downstream of the turns in the second passage with flow inward and in the third passage with flow outward was also a function of model orientation with differences as large as 40 to 50 percent occurring between the model orientations with forward flow and rearward flow of coolant.

  4. Stack zooming for multifocus interaction in skewed-aspect visual spaces.

    PubMed

    Javed, Waqas; Elmqvist, Niklas

    2013-08-01

    Many 2D visual spaces have a virtually one-dimensional nature with very high aspect ratio between the dimensions: examples include time-series data, multimedia data such as sound or video, text documents, and bipartite graphs. Common among these is that the space can become very large, e.g., temperature measurements could span a long time period, surveillance video could cover entire days or weeks, and documents can have thousands of pages. Many analysis tasks for such spaces require several foci while retaining context and distance awareness. In this extended version of our IEEE PacificVis 2010 paper, we introduce a method for supporting this kind of multifocus interaction that we call stack zooming. The approach is based on building hierarchies of 1D strips stacked on top of each other, where each subsequent stack represents a higher zoom level, and sibling strips represent branches in the exploration. Correlation graphics show the relation between stacks and strips of different levels, providing context and distance awareness for the foci. The zoom hierarchies can also be used as graphical histories and for communicating insights to stakeholders and can be further extended with annotation and integrated statistics. PMID:23744266

  5. Title I Weighted Grants Skewed Toward Largest Districts: Per Pupil Funding Varies Sharply by District Size

    ERIC Educational Resources Information Center

    Rural School and Community Trust, 2007

    2007-01-01

    Since 2002, some of the federal funds provided to local school districts under Title I of the Elementary and Secondary Education Act have been distributed through "weighted" grant formulas intended to better target funding to districts with the highest concentrations of poverty. These weighted grant formulas have produced some perverse effects:…

  6. Determination of quadric equation coefficients describing three-dimensional surfaces, their constraint and skewed planes, and view point areas

    NASA Technical Reports Server (NTRS)

    Paoletti, C. J.; Pond, J. E.; Vance, J. H.

    1969-01-01

    Mathematical model and a digital computer BLITZ language programming technique computes coefficients of quadric equations describing cylinders, paraboloids, ellipsoids, or planes with any orientation to a reference system, coordinates of a vector, and coefficients of quadric surfaces which limit the surface of three-dimensional space.

  7. Skew-symmetric Random Effect Models with Application to a Preventive Cohort Study: Improving Outcomes in Low Back Pain Patients

    PubMed Central

    Mansourian, Marjan; Mahdiyeh, Zahra; Park, Jongbae J; Haghjooyejavanmard, Shaghayegh

    2013-01-01

    Background: To investigate the respective contribution of various biologic and psychosocial factors, especially Health Related Quality of Life (HRQOL) as a main outcome, in the natural history of acute low back pain (LBP) and to evaluate the impact of this condition on HRQOL. Methods: In a prospective cohort study For 24 weeks, 150 patients were assessed at an outpatient clinic in Korea consulting for low back and confirmed disc herniation duration at inclusion and treated with treatment package comprised of herbal medicines, acupuncture, bee venom acupuncture, and a Korean version of spinal manipulation (Chuna). Study participants were evaluated at baseline and every 4 weeks for 24 weeks. Low back intensity levels were measured on a visual analog scale (0-10), back function was evaluated with the Oswestry Disability Index (0-100), disability assessed by HRQOL assessed by the short form 36 health survey (0-100 in 8 different sub-categories). Results: Out of 150 patients, 128 completed the 24 weeks of traditional therapy. Patients reported improvements SF-36 outcome measures. At the completion of the study, low back pain scores improved by a mean of 3.3 (95% CI = 2.8 to 3.8). According to the results of our modeling, low back intensity level, back function and BMI measures had significant effects on quality of life during study. Interpreting the coefficients of modeling, the impact of the decreasing acute LBP episode on HRQOL by VAS and ODI outcomes, was high and important. Conclusions: This study highlights the large contribution of integrative package therapy as an effective preventive method for improving LBP patient's HRQOL. PMID:23626884

  8. Monocyte Subpopulations from Pre-Eclamptic Patients Are Abnormally Skewed and Exhibit Exaggerated Responses to Toll-Like Receptor Ligands

    PubMed Central

    Al-ofi, Ebtisam

    2012-01-01

    The leading cause of pregnancy-associated mortality and morbidity is pre-eclampsia (PE). Although information regarding the etiology of this disease is scant, its pathophysiology is characterized by abnormal placentation, endothelial dysfunction as well as an exaggerated inflammatory response. Clinical evidence also indicates that the abundance of many immune cells at the feto-maternal interface and in the circulation of PE patients is abnormal, when compared with normal pregnant (NP) controls. In addition, the phenotype and function of some of these cells is altered. To further characterize the systemic effects of PE on circulating cells, we analyzed monocytic subpopulations in NP and PE patients by flow cytometry. We found that non-classical CD14lowCD16+ monocytes are significantly increased in women with PE and they display irregular expression of several chemokine receptors and antigen presentation molecules. The most striking phenotypic difference among the cell surface molecules was the marked upregulation of TLR4 expression, where both CD14highCD16+ and CD14lowCD16+ monocytes demonstrated higher levels than their NP counterparts. Stimulation of PE monocytes with TLR ligands resulted in profound secretion of various cytokines in comparison with NP controls. These data suggest that PE monocytes are hyper-responsive to TLR ligands and this may contribute to exacerbation of the disease. PMID:22848746

  9. The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies.

    PubMed

    Macrì, Simone; Ceci, Chiara; Altabella, Luisa; Canese, Rossella; Laviola, Giovanni

    2013-01-01

    All laboratory animals shall be provided some form of environmental enrichment (EE) in the nearest future (Directive 2010/63/EU). Displacing standard housing with EE entails the possibility that data obtained under traditional housing may be reconsidered. Specifically, while EE often contrasts the abnormalities of consolidated disease models, it also indirectly demonstrates that their validity depends on housing conditions. We mimicked a situation in which the consequences of a novel pharmacological compound were addressed before and after the adoption of the Directive. We sub-chronically exposed standard- or EE-reared adolescent CD1 mice (postnatal days 23-33) to the synthetic compound JWH-018, and evaluated its short- and long-term potential cannabinoid properties on: weight gain, locomotion, analgesia, motor coordination, body temperature, brain metabolism ((1)H MRI/MRS), anxiety- and depressive-related behaviours. While several parameters are modulated by JWH-018 independently of housing, other effects are environmentally mediated. The transition from standard housing to EE shall be carefully monitored.

  10. Anti‐Inflammatory Immune Skewing Is Atheroprotective: Apoe−/−FcγRIIb−/− Mice Develop Fibrous Carotid Plaques

    PubMed Central

    Harmon, Erin Y.; Fronhofer, Van; Keller, Rebecca S.; Feustel, Paul J.; Zhu, Xinmei; Xu, Hao; Avram, Dorina; Jones, David M.; Nagarajan, Shanmugam; Lennartz, Michelle R.

    2014-01-01

    Background Stroke, caused by carotid plaque rupture, is a major cause of death in the United States. Whereas vulnerable human plaques have higher Fc receptor (FcγR) expression than their stable counterparts, how FcγR expression impacts plaque histology is unknown. We investigated the role of FcγRIIb in carotid plaque development and stability in apolipoprotein (Apo)e−/− and Apoe−/−FcγRIIb−/− double knockout (DKO) animals. Methods and Results Plaques were induced by implantation of a shear stress‐modifying cast around the carotid artery. Plaque length and stenosis were followed longitudinally using ultrasound biomicroscopy. Immune status was determined by flow cytometry, cytokine release, immunoglobulin G concentration and analysis of macrophage polarization both in plaques and in vitro. Surprisingly, DKO animals had lower plaque burden in both carotid artery and descending aorta. Plaques from Apoe−/− mice were foam‐cell rich and resembled vulnerable human specimens, whereas those from DKO mice were fibrous and histologically stable. Plaques from DKO animals expressed higher arginase 1 (Arg‐1) and lower inducible nitric oxide synthase (iNOS), indicating the presence of M2 macrophages. Analysis of blood and cervical lymph nodes revealed higher interleukin (IL)‐10, immune complexes, and regulatory T cells (Tregs) and lower IL‐12, IL‐1β, and tumor necrosis factor alpha (TNF‐α) in DKO mice. Similarly, in vitro stimulation produced higher IL‐10 and Arg‐1 and lower iNOS, IL‐1β, and TNF‐α in DKO versus Apoe−/− macrophages. These results define a systemic anti‐inflammatory phenotype. Conclusions We hypothesized that removal of FcγRIIb would exacerbate atherosclerosis and generate unstable plaques. However, we found that deletion of FcγRIIb on a congenic C57BL/6 background induces an anti‐inflammatory Treg/M2 polarization that is atheroprotective. PMID:25516435

  11. Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers

    PubMed Central

    Mauri, Giorgio; Jachetti, Elena; Comuzzi, Barbara; Dugo, Matteo; Arioli, Ivano; Miotti, Silvia; Sangaletti, Sabina; Di Carlo, Emma; Tripodo, Claudio; Colombo, Mario P.

    2016-01-01

    Osteopontin (OPN) is a secreted glycoprotein, that belongs to the non-structural extracellular matrix (ECM), and its over expression in human prostate cancer has been associated with disease progression, androgen independence and metastatic ability. Nevertheless, the pathophysiology of OPN in prostate tumorigenesis has never been studied. We crossed TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice with OPN deficient (OPN−/−) mice and followed tumor onset and progression in these double mutants. Ultrasound examination detected the early onset of a rapidly growing, homogeneous and spherical tumor in about 60% of OPN−/− TRAMP mice. Such neoplasms seldom occurred in parental TRAMP mice otherwise prone to adenocarcinomas and were characterized for being androgen receptor negative, highly proliferative and endowed with neuroendocrine (NE) features. Gene expression profiling showed up-regulation of genes involved in tumor progression, cell cycle and neuronal differentiation in OPN-deficient versus wild type TRAMP tumors. Down-regulated genes included key genes of TGFa pathway, including SMAD3 and Filamin, which were confirmed at the protein level. Furthermore, NE genes and particularly those characterizing early prostatic lesions of OPN-deficient mice were found to correlate with those of human prostate NE tumours. These data underscore a novel role of OPN in the early stages of prostate cancer growth, protecting against the development of aggressive NE tumors. PMID:26700622

  12. The skewed N:P stoichiometry resulting from anthropogenic drivers regulate production of transparent exopolymer particles (TEP) in Ganga River.

    PubMed

    Pandey, Usha; Pandey, Jitendra

    2015-01-01

    Transparent exopolymer particles (TEP), generated from excretion products of microalgae, trigger flocculation of diatoms and sinking of organic matter. Investigations along 797 km stretch of Ganga River indicated that TEP declined with increasing N:P stoichiometric ratio downstream. The TEP showed positive relationship with chlorophyll a (R(2) = 0.9661; p < 0.0001) and biogenic silica (R(2) = 0.8797; p < 0.0001) and negative relationship (R(2) = 0.8547; p < 0.0001) with N:P ratio. The study that forms the first report on N:P linked changes in TEP in Ganga River showed that the shifting N:P stoichiometric ratios resulting from anthropogenic release may alter TEP production and, by implication, ecosystem functioning including carbon sequestration in the river.

  13. Higher numbers of memory B-cells and Th2-cytokine skewing in high responders to hepatitis B vaccination.

    PubMed

    Doedée, A M C M; Kannegieter, N; Öztürk, K; van Loveren, H; Janssen, R; Buisman, A M

    2016-04-27

    In the present study, differences in hepatitis B surface antigen (HBsAg)-specific memory B-cell responses between low and high responders to hepatitis B vaccine (HepB), based on levels of antibodies against HBsAg (anti-HBs), were determined. In addition, HBsAg specific T-cell responses between high (anti-HBs level >20,000 IU/L) and low (anti-HBs level <1500 IU/L) responders were compared. Numbers of HBsAg-specific B-cells, plasma immunoglobulin G (Ig) levels, and T-cell cytokine concentrations were measured in low and high responders directly before and one month after the second booster vaccination. In advance, an Enzyme-linked Immunosorbent Spot (ELISpot) Assay was optimized for the determination of HBsAg-specific B-cell responses. The number of HBsAg-specific B-cells was significantly higher (p<0.01) in the high responder group compared to the low responder group after a booster vaccination with HepB. In addition, the plasma IgG levels and numbers of HBsAg-specific B-cells were significantly correlated (RS=0.66, p<0.01). The HBsAg-specific Th1 cell response showed the same values in the low and high responder group and did not change by the booster vaccination with HepB. However, a significant correlation (RS=0.6975, p=0.007) between the IL-13 levels and the plasma IgG levels post-booster was found. Subsequently, the IL-13 level in the high-responder group post-booster was significantly higher compared to the low-responder group. Since activation of the B-cell response after vaccination is induced by Th2 cells and IL-13 is produced by these cells, we conclude that the difference in HBsAg-specific Th2 cells is involved in determining the differences in anti-HBs level and memory B-cell numbers between low and high responders.

  14. Arabinosylated Lipoarabinomannan Skews Th2 Phenotype towards Th1 during Leishmania Infection by Chromatin Modification: Involvement of MAPK Signaling

    PubMed Central

    Bhattacharya, Parna; Gupta, Gaurav; Majumder, Saikat; Adhikari, Anupam; Banerjee, Sayantan; Halder, Kuntal; Bhattacharya Majumdar, Suchandra; Ghosh, Moumita; Chaudhuri, Shubho; Roy, Syamal; Majumdar, Subrata

    2011-01-01

    The parasitic protozoan Leishmania donovani is the causative organism for visceral leishmaniasis (VL) which persists in the host macrophages by deactivating its signaling machinery resulting in a critical shift from proinflammatory (Th1) to an anti-inflammatory (Th2) response. The severity of this disease is mainly determined by the production of IL-12 and IL-10 which could be reversed by use of effective immunoprophylactics. In this study we have evaluated the potential of Arabinosylated Lipoarabinomannan (Ara-LAM), a cell wall glycolipid isolated from non pathogenic Mycobacterium smegmatis, in regulating the host effector response via effective regulation of mitogen-activated protein kinases (MAPK) signaling cascades in Leishmania donovani infected macrophages isolated from BALB/C mice. Ara-LAM, a Toll-like receptor 2 (TLR2) specific ligand, was found to activate p38 MAPK signaling along with subsequent abrogation of extracellular signal–regulated kinase (ERKs) signaling. The use of pharmacological inhibitors of p38MAPK and ERK signaling showed the importance of these signaling pathways in the regulation of IL-10 and IL-12 in Ara-LAM pretreated parasitized macrophages. Molecular characterization of this regulation of IL-10 and IL-12 was revealed by chromatin immunoprecipitation assay (CHIP) which showed that in Ara-LAM pretreated parasitized murine macrophages there was a significant induction of IL-12 by selective phosphorylation and acetylation of histone H3 residues at its promoter region. While, IL-10 production was attenuated by Ara-LAM pretreatment via abrogation of histone H3 phosphorylation and acetylation at its promoter region. This Ara-LAM mediated antagonistic regulations in the induction of IL-10 and IL-12 genes were further correlated to changes in the transcriptional regulators Signal transducer and activator of transcription 3 (STAT3) and Suppressor of cytokine signaling 3 (SOCS3). These results demonstrate the crucial role played by Ara-LAM in regulating the MAPK signaling pathway along with subsequent changes in host effector response during VL which might provide crucial clues in understanding the Ara-LAM mediated protection during Leishmania induced pathogenesis. PMID:21935379

  15. Bovine Immune Response to Papillomatous Digital Dermatitis (PDD)-associated Spirochetes is Skewed in Isolate Reactivity and Subclass Elicitation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Papillomatous digital dermatitis (PDD), also known as hairy heel wart, is a growing cause of lameness of cows in the U.S. dairy industry. Farms with PDD-afflicted cows experience economic loss due to treatment costs, decreased milk production, lower reproductive efficiency and premature culling. Cow...

  16. Bovine Immune Response to Papillomatous Digital Dermatitis (PDD)-Associated Spirochetes are Skewed in Isolate Reactivity and Subclass Elicitation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background: Papillomatous digital dermatitis (PDD), also known as hairy heel wart, is a growing cause of lameness of cows in the U.S. dairy industry. Previous work using lesion material from a dairy farm in Iowa resulted in the isolation of four different Treponema phagedenis-like spirochetes (1A, 3...

  17. The skewed N:P stoichiometry resulting from anthropogenic drivers regulate production of transparent exopolymer particles (TEP) in Ganga River.

    PubMed

    Pandey, Usha; Pandey, Jitendra

    2015-01-01

    Transparent exopolymer particles (TEP), generated from excretion products of microalgae, trigger flocculation of diatoms and sinking of organic matter. Investigations along 797 km stretch of Ganga River indicated that TEP declined with increasing N:P stoichiometric ratio downstream. The TEP showed positive relationship with chlorophyll a (R(2) = 0.9661; p < 0.0001) and biogenic silica (R(2) = 0.8797; p < 0.0001) and negative relationship (R(2) = 0.8547; p < 0.0001) with N:P ratio. The study that forms the first report on N:P linked changes in TEP in Ganga River showed that the shifting N:P stoichiometric ratios resulting from anthropogenic release may alter TEP production and, by implication, ecosystem functioning including carbon sequestration in the river. PMID:25106773

  18. Microsatellite marker analysis of an anther-derived potato family: skewed segregation and gene-centromere mapping.

    PubMed

    Chani, Eduard; Ashkenazi, Varda; Hillel, Jossi; Veilleux, Richard E

    2002-04-01

    Segregation patterns of polymorphic simple sequence repeat (SSR) primer pairs were investigated in monoploid potato families derived from anther culture. A total of 14 primers developed from the sequences in the database, as well as from a genomic library of potato, was used. Distorted segregation was observed for seven (50%) polymorphic loci among monoploids derived from an interspecific hybrid. Similar distortion was observed for only one of five loci that could be contrasted between the two monoploid families. Segregation distortion was less common in the sexually derived backcross population between the interspecific hybrid and either of its parents. One locus could be putatively linked to a lethal allele because it showed distorted segregation in both monoploid families, a group of 70 heterozygous diploids derived from unreduced gametes through anther culture, and a backcross population. These diploids were used to map the polymorphic SSR markers with respect to the centromeres using half-tetrad analysis. The majority of the SSR loci mapped more than 33 cM from the centromere, suggesting the occurrence of a single crossover per chromosome arm. PMID:11962620

  19. The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies

    PubMed Central

    Macrì, Simone; Ceci, Chiara; Altabella, Luisa; Canese, Rossella; Laviola, Giovanni

    2013-01-01

    All laboratory animals shall be provided some form of environmental enrichment (EE) in the nearest future (Directive 2010/63/EU). Displacing standard housing with EE entails the possibility that data obtained under traditional housing may be reconsidered. Specifically, while EE often contrasts the abnormalities of consolidated disease models, it also indirectly demonstrates that their validity depends on housing conditions. We mimicked a situation in which the consequences of a novel pharmacological compound were addressed before and after the adoption of the Directive. We sub-chronically exposed standard- or EE-reared adolescent CD1 mice (postnatal days 23-33) to the synthetic compound JWH-018, and evaluated its short- and long-term potential cannabinoid properties on: weight gain, locomotion, analgesia, motor coordination, body temperature, brain metabolism (1H MRI/MRS), anxiety- and depressive-related behaviours. While several parameters are modulated by JWH-018 independently of housing, other effects are environmentally mediated. The transition from standard housing to EE shall be carefully monitored. PMID:23924859

  20. Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

    PubMed Central

    Krejcik, Jakub; Casneuf, Tineke; Nijhof, Inger S.; Verbist, Bie; Bald, Jaime; Plesner, Torben; Syed, Khaja; Liu, Kevin; van de Donk, Niels W. C. J.; Weiss, Brendan M.; Ahmadi, Tahamtan; Lokhorst, Henk M.; Mutis, Tuna

    2016-01-01

    Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target nonplasma cells that express CD38, which prompted evaluation of daratumumab’s effects on CD38-positive immune subpopulations. Peripheral blood (PB) and bone marrow (BM) from patients with relapsed/refractory myeloma from 2 daratumumab monotherapy studies were analyzed before and during therapy and at relapse. Regulatory B cells and myeloid-derived suppressor cells, previously shown to express CD38, were evaluated for immunosuppressive activity and daratumumab sensitivity in the myeloma setting. A novel subpopulation of regulatory T cells (Tregs) expressing CD38 was identified. These Tregs were more immunosuppressive in vitro than CD38-negative Tregs and were reduced in daratumumab-treated patients. In parallel, daratumumab induced robust increases in helper and cytotoxic T-cell absolute counts. In PB and BM, daratumumab induced significant increases in CD8+:CD4+ and CD8+:Treg ratios, and increased memory T cells while decreasing naïve T cells. The majority of patients demonstrated these broad T-cell changes, although patients with a partial response or better showed greater maximum effector and helper T-cell increases, elevated antiviral and alloreactive functional responses, and significantly greater increases in T-cell clonality as measured by T-cell receptor (TCR) sequencing. Increased TCR clonality positively correlated with increased CD8+ PB T-cell counts. Depletion of CD38+ immunosuppressive cells, which is associated with an increase in T-helper cells, cytotoxic T cells, T-cell functional response, and TCR clonality, represents possible additional mechanisms of action for daratumumab and deserves further exploration. PMID:27222480

  1. Dead Lactobacillus plantarum Stimulates and Skews Immune Responses toward T helper 1 and 17 Polarizations in RAW 264.7 Cells and Mouse Splenocytes.

    PubMed

    Lee, Hyun Ah; Kim, Hyunung; Lee, Kwang-Won; Park, Kun-Young

    2016-03-01

    This study was undertaken to evaluate the immunomodulatory effect of dead nano-sized Lactobacillus plantarum (nLp) in RAW 264.7 cells and murine primary splenocytes. nLp is a dead, shrunken, processed form of L. plantarum nF1 isolated from kimchi (a traditional Korean fermented cabbage) and is less than 1 μm in size. It was found that nLp treatment stimulated nitric oxide (NO) production more in RAW 264.7 macrophages than pure live L. plantarum (pLp), and that the stimulatory properties were probably largely derived from its cell wall. In addition, nLp induced murine splenocyte proliferation more so than pLp; in particular, a high dose of nLp (1.0 X 10(11) CFU/ml) stimulated proliferation as much as lipopolysaccharide at 2 μg/ml. Moreover, according to our cytokine profile results in splenocytes, nLp treatment promoted Th1 (TNF-α, IL-12 p70) responses rather than Th2 (IL-4, IL-5) responses and also increased Th17 (IL-6, IL-17A) responses. Thus, nLp stimulated NO release in RAW 264.7 cells and induced splenocyte proliferation more so than pLp and stimulated Th1 and Th17 cytokine production. These findings suggested that dead nLp has potential use as a functional food ingredient to improve the immune response, and especially as a means of inducing Th1/Th17 immune responses.

  2. Non-random pairing of CD46 isoforms with skewing towards BC2 and C2 in activated and memory/effector T cells

    PubMed Central

    Hansen, Aida S.; Bundgaard, Bettina B.; Møller, Bjarne K.; Höllsberg, Per

    2016-01-01

    CD46 is a glycoprotein with important functions in innate and adaptive immune responses. Functionally different isoforms are generated by alternative splicing at exons 7–9 (BC and C isoforms) and exon 13 (CYT-1 and CYT-2 isoforms) giving rise to BC1, BC2, C1 and C2. We developed a novel real-time PCR assay that allows quantitative comparisons between these isoforms. Their relative frequency in CD4+ T cells from 100 donors revealed a distribution with high interpersonally variability. Importantly, the distribution between the isoforms was not random and although splicing favoured inclusion of exon 8 (BC isoforms), exclusion of exon 8 (C isoforms) was significantly linked to exclusion of exon 13 (CYT-2 isoforms). Despite inter-individual differences, CD4+ and CD8+ T cells, B cells, NK cells and monocytes expressed similar isoform profiles intra-individually. However, memory/effector CD4+ T cells had a significantly higher frequency of CYT-2 when compared with naïve CD4+ T cells. Likewise, in vitro activation of naïve and total CD4+ T cells increased the expression of CYT-2. This indicates that although splicing factors determine a certain expression profile in an individual, the profile can be modulated by external stimuli. This suggests a mechanism by which alterations in CD46 isoforms may temporarily regulate the immune response. PMID:27739531

  3. Indexing the relative abundance of age-0 white sturgeons in an impoundment of the lower Columbia River from highly skewed trawling data

    USGS Publications Warehouse

    Counihan, T.D.; Miller, A.I.; Parsley, M.J.

    1999-01-01

    The development of recruitment monitoring programs for age-0 white sturgeons Acipenser transmontanus is complicated by the statistical properties of catch-per-unit-effort (CPUE) data. We found that age-0 CPUE distributions from bottom trawl surveys violated assumptions of statistical procedures based on normal probability theory. Further, no single data transformation uniformly satisfied these assumptions because CPUE distribution properties varied with the sample mean (??(CPUE)). Given these analytic problems, we propose that an additional index of age-0 white sturgeon relative abundance, the proportion of positive tows (Ep), be used to estimate sample sizes before conducting age-0 recruitment surveys and to evaluate statistical hypothesis tests comparing the relative abundance of age-0 white sturgeons among years. Monte Carlo simulations indicated that Ep was consistently more precise than ??(CPUE), and because Ep is binomially rather than normally distributed, surveys can be planned and analyzed without violating the assumptions of procedures based on normal probability theory. However, we show that Ep may underestimate changes in relative abundance at high levels and confound our ability to quantify responses to management actions if relative abundance is consistently high. If data suggest that most samples will contain age-0 white sturgeons, estimators of relative abundance other than Ep should be considered. Because Ep may also obscure correlations to climatic and hydrologic variables if high abundance levels are present in time series data, we recommend ??(CPUE) be used to describe relations to environmental variables. The use of both Ep and ??(CPUE) will facilitate the evaluation of hypothesis tests comparing relative abundance levels and correlations to variables affecting age-0 recruitment. Estimated sample sizes for surveys should therefore be based on detecting predetermined differences in Ep, but data necessary to calculate ??(CPUE) should also be collected.

  4. Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity.

    PubMed

    Vallelian, Florence; Schaer, Christian A; Kaempfer, Theresa; Gehrig, Peter; Duerst, Elena; Schoedon, Gabriele; Schaer, Dominik J

    2010-12-01

    Glucocorticoids are used extensively to treat autoimmune hemolytic anemias. Some beneficial effects of glucocorticoid pulse therapy have also been reported in sickle cell disease and paroxysmal nocturnal hemoglobinuria. Based on established concepts of hemoglobin (Hb) toxicity and physiologic Hb scavenger systems, we evaluated whether glucocorticoids could support an adaptive response to extracellular Hb independently of their immunosuppressive activities. Using global proteome and transcriptome analysis with mass-spectrometry (isobaric tag for relative and absolute quantitation and liquid chromatography-mass spectrometry) and gene-array experiments, we found that glucocorticoid treatment in vitro and in patients on glucocorticoid-pulse therapy polarized monocytes into a M2/alternatively activated phenotype with high Hb-scavenger receptor (CD163) expression and enhanced Hb-clearance and detoxification capability. Monocytes concurrently exposed to the interactive activity of glucocorticoids and extracellular Hb were characterized by high expression of a group of antioxidant enzymes known to be regulated by the conserved oxidative response transcription factor nuclear factor E2-related factor. Further, suppressed transferrin receptor, together with high ferroportin expression, pointed to a shift in iron homeostasis directed toward an increased cellular export of heme-derived iron. Therefore, stimulating Hb-endocytosis by CD163 and enhancing antioxidative homeostasis and iron recycling may be an essential activity of glucocorticoids that helps alleviate the adverse effects of extracellular Hb. PMID:20739658

  5. A Model Comparison for Count Data with a Positively Skewed Distribution with an Application to the Number of University Mathematics Courses Completed

    ERIC Educational Resources Information Center

    Liou, Pey-Yan

    2009-01-01

    The current study examines three regression models: OLS (ordinary least square) linear regression, Poisson regression, and negative binomial regression for analyzing count data. Simulation results show that the OLS regression model performed better than the others, since it did not produce more false statistically significant relationships than…

  6. 1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

    PubMed Central

    Schedel, Michaela; Jia, Yi; Michel, Sven; Takeda, Katsuyuki; Domenico, Joanne; Joetham, Anthony; Ning, Fangkun; Strand, Matthew; Han, Junyan; Wang, Meiqin; Lucas, Joseph J.; Vogelberg, Christian; Kabesch, Michael; O'Connor, Brian P.; Gelfand, Erwin W.

    2016-01-01

    Effector CD8+ T cells convert from IFN-γ+ (Tc1) to IL-13+ (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here, we show that addition of 1,25D3, the active form of vitamin D3, during CD8+ T-cell differentiation prevents IL-4-induced conversion to IL-13-producers. Transfer of 1,25D3-treated CD8+ T cells into sensitized and challenged CD8+-deficient recipients fails to restore development of lung allergic responses. 1,25D3 alters vitamin D receptor (VDR) recruitment to the Cyp11a1 promoter in vitro and in vivo in the presence of IL-4. As a result, protein levels and enzymatic activity of CYP11A1, a steroidogenic enzyme regulating CD8+ T-cell conversion, are decreased. An epistatic effect between CYP11A1 and VDR polymorphisms may contribute to the predisposition to childhood asthma. These data identify a role for 1,25D3 in the molecular programming of CD8+ T-cell conversion to an IL-13-secreting phenotype through regulation of steroidogenesis, potentially governing asthma susceptibility. PMID:26750596

  7. Highly skewed distribution of miRNAs and proteins between colorectal cancer cells and their exosomes following Cetuximab treatment: biomolecular, genetic and translational implications

    PubMed Central

    Barbagallo, Cristina; Passanisi, Roberta; Alhamdani, Mohamed S.; Destri, Giovanni Li; Cappellani, Alessandro; Barbagallo, Davide; Scalia, Marina; Valadi, Hadi

    2014-01-01

    Exchange of molecules via exosomes is a means of eukaryotic intercellular communication, especially within tumour microenvironments. However, no data are available on alterations of exosomal molecular cargo by environmental cues (eg, pharmacological treatments). To approach this issue, we compared the abundance of 754 miRNAs and 741 cancer-related proteins in exosomes secreted by Caco-2 (Cetuximab-responsive) and HCT- 116 (Cetuximab-resistant) CRC cells, before and after Cetuximab treatment, with that in their source cells. Cetuximab significantly altered the cargo of Caco-2 exosomes: it increased abundance of miRNAs and proteins activating proliferation and inflammation and reduced miRNAs and proteins related to immune suppression. These alterations did not precisely mirror those in source cells, suggesting a Cetuximab-linked effect. Analogous alterations were detected in HCT-116. Transfection of exosomes from Cetuximab-treated Caco-2 into HCT-116 significantly increased HCT-116 viability; conversely, no viability alteration was detected in Caco-2 transfected with exosomes from Cetuximab-treated HCT-116. Analysis of networks, comprising targets of differentially expressed (DE) exosomal miRNAs and DE exosomal proteins, demonstrates a significant involvement of processes related to proliferation, inflammation, immune response, apoptosis. Our data extend existing knowledge on molecular mechanisms of eukaryotic intercellular communication, especially in oncological processes. Their translation to clinical settings may add new weapons to existing therapeutic repertoires against cancer. PMID:25594007

  8. Dead Lactobacillus plantarum Stimulates and Skews Immune Responses toward T helper 1 and 17 Polarizations in RAW 264.7 Cells and Mouse Splenocytes.

    PubMed

    Lee, Hyun Ah; Kim, Hyunung; Lee, Kwang-Won; Park, Kun-Young

    2016-03-01

    This study was undertaken to evaluate the immunomodulatory effect of dead nano-sized Lactobacillus plantarum (nLp) in RAW 264.7 cells and murine primary splenocytes. nLp is a dead, shrunken, processed form of L. plantarum nF1 isolated from kimchi (a traditional Korean fermented cabbage) and is less than 1 μm in size. It was found that nLp treatment stimulated nitric oxide (NO) production more in RAW 264.7 macrophages than pure live L. plantarum (pLp), and that the stimulatory properties were probably largely derived from its cell wall. In addition, nLp induced murine splenocyte proliferation more so than pLp; in particular, a high dose of nLp (1.0 X 10(11) CFU/ml) stimulated proliferation as much as lipopolysaccharide at 2 μg/ml. Moreover, according to our cytokine profile results in splenocytes, nLp treatment promoted Th1 (TNF-α, IL-12 p70) responses rather than Th2 (IL-4, IL-5) responses and also increased Th17 (IL-6, IL-17A) responses. Thus, nLp stimulated NO release in RAW 264.7 cells and induced splenocyte proliferation more so than pLp and stimulated Th1 and Th17 cytokine production. These findings suggested that dead nLp has potential use as a functional food ingredient to improve the immune response, and especially as a means of inducing Th1/Th17 immune responses. PMID:26699750

  9. The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart.

    PubMed

    Haan, Serge; Bahlawane, Christelle; Wang, Jiali; Nazarov, Petr V; Muller, Arnaud; Eulenfeld, René; Haan, Claude; Rolvering, Catherine; Vallar, Laurent; Satagopam, Venkata P; Sauter, Thomas; Wiesinger, Monique Yvonne

    2015-01-01

    Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRα kinase exhibits a significantly different signaling pattern compared to its PDGFRα wild type counterpart. Interestingly, the activation of primarily membrane-based signal transduction processes (such as PI3-kinase- and MAP-kinase- pathways) is remarkably shifted toward a prominent activation of STAT factors. This diverging signaling pattern compared to classical PDGF-receptor signaling is partially coupled to the aberrant cytoplasmic localization of the oncogene, since membrane targeting of FIP1L1-PDGFRα restores activation of MAPK- and PI3K-pathways. In stark contrast to the classical cytokine-induced STAT activation process, STAT activation by FIP1L1-PDGFRα does neither require Janus kinase activity nor Src kinase activity. Furthermore, we investigated the mechanism of STAT5 activation via FIP1L1-PDGFRα in more detail and found that STAT5 activation does not involve an SH2-domain-mediated binding mechanism. We thus demonstrate that STAT5 activation occurs via a non-canonical activation mechanism in which STAT5 may be subject to a direct phosphorylation by FIP1L1-PDGFRα. PMID:26413425

  10. The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

    PubMed Central

    Haan, Serge; Bahlawane, Christelle; Wang, Jiali; Nazarov, Petr V; Muller, Arnaud; Eulenfeld, René; Haan, Claude; Rolvering, Catherine; Vallar, Laurent; Satagopam, Venkata P; Sauter, Thomas; Wiesinger, Monique Yvonne

    2015-01-01

    Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRα kinase exhibits a significantly different signaling pattern compared to its PDGFRα wild type counterpart. Interestingly, the activation of primarily membrane-based signal transduction processes (such as PI3-kinase- and MAP-kinase- pathways) is remarkably shifted toward a prominent activation of STAT factors. This diverging signaling pattern compared to classical PDGF-receptor signaling is partially coupled to the aberrant cytoplasmic localization of the oncogene, since membrane targeting of FIP1L1-PDGFRα restores activation of MAPK- and PI3K-pathways. In stark contrast to the classical cytokine-induced STAT activation process, STAT activation by FIP1L1-PDGFRα does neither require Janus kinase activity nor Src kinase activity. Furthermore, we investigated the mechanism of STAT5 activation via FIP1L1-PDGFRα in more detail and found that STAT5 activation does not involve an SH2-domain-mediated binding mechanism. We thus demonstrate that STAT5 activation occurs via a non-canonical activation mechanism in which STAT5 may be subject to a direct phosphorylation by FIP1L1-PDGFRα. PMID:26413425

  11. Peripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen.

    PubMed

    Llorens-Martín, M; Jurado-Arjona, J; Fuster-Matanzo, A; Hernández, F; Rábano, A; Ávila, J

    2014-01-01

    Both familial and sporadic forms of Alzheimer disease (AD) present memory impairments. It has been proposed that these impairments are related to inflammation in relevant brain areas such as the hippocampus. Whether peripherally triggered and neuron-driven brain inflammation produce similar and equally reversible alterations is a matter of discussion. Here we studied the effects of ibuprofen administration on a familial AD mouse model overexpressing GSK-3β that presents severe brain inflammation. We compared these effects with those observed in a peripherally triggered brain inflammation model based on chronic lipopolysaccharide (LPS) administration. Both proinflammatory stimuli produced equivalent reversible morphological alterations in granule neurons; however, GSK-3β had a much more prominent role in newborn neuron connectivity, causing alterations that were not reversed by ibuprofen. Although both insults triggered similar behavioral impairments, ibuprofen rescued this defect in LPS-treated mice but did not produce any improvement in GSK-3β-overexpressing animals. This observation could be attributable to the different microglial phenotype induced by ibuprofen treatment. These data may be clinically relevant for AD therapies, as GSK-3β appears to determine the efficacy of ibuprofen treatment.

  12. Viable School Improvement Requires a Developmental Strategy that Moves beyond the Skewed Wish List and Reworks Operational Infrastructure. A Center Brief

    ERIC Educational Resources Information Center

    Center for Mental Health in Schools at UCLA, 2011

    2011-01-01

    factors affecting learning and teaching and how the operational infrastructure is reworked to enable strategic and effective development of essential interventions. This is especially so for schools that…

  13. Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells.

    PubMed

    Covarrubias, Roman; Wilhelm, Ashley J; Major, Amy S

    2014-01-01

    Expression of molecules involved in lipid homeostasis such as the low density lipoprotein receptor (LDLr) on antigen presenting cells (APCs) has been shown to enhance invariant natural killer T (iNKT) cell function. However, the contribution to iNKT cell activation by other lipoprotein receptors with shared structural and ligand binding properties to the LDLr has not been described. In this study, we investigated whether a structurally related receptor to the LDLr, known as LDL receptor-related protein (LRP), plays a role in iNKT cell activation. We found that, unlike the LDLr which is highly expressed on all immune cells, the LRP was preferentially expressed at high levels on F4/80+ macrophages (MΦ). We also show that CD169+ MΦs, known to present antigen to iNKT cells, exhibited increased expression of LRP compared to CD169- MΦs. To test the contribution of MΦ LRP to iNKT cell activation we used a mouse model of MΦ LRP conditional knockout (LRP-cKO). LRP-cKO MΦs pulsed with glycolipid alpha-galactosylceramide (αGC) elicited normal IL-2 secretion by iNKT hybridoma and in vivo challenge of LRP-cKO mice led to normal IFN-γ, but blunted IL-4 response in both serum and intracellular expression by iNKT cells. Flow cytometric analyses show similar levels of MHC class-I like molecule CD1d on LRP-cKO MΦs and normal glycolipid uptake. Survey of the iNKT cell compartment in LRP-cKO mice revealed intact numbers and percentages and no homeostatic disruption as evidenced by the absence of programmed death-1 and Ly-49 surface receptors. Mixed bone marrow chimeras showed that the inability iNKT cells to make IL-4 is cell extrinsic and can be rescued in the presence of wild type APCs. Collectively, these data demonstrate that, although MΦ LRP may not be necessary for IFN-γ responses, it can contribute to iNKT cell activation by enhancing early IL-4 secretion.

  14. Skew photonic Doppler velocimetry to investigate the expansion of a cloud of droplets created by micro-spalling of laser shock-melted metal foils

    SciTech Connect

    Loison, D.; Resseguier, T. de; Dragon, A.; Mercier, P.; Benier, J.; Deloison, G.; Lescoute, E.; Sollier, A.

    2012-12-01

    Dynamic fragmentation in the liquid state after shock-induced melting, usually referred to as micro-spallation, is an issue of great interest for both basic and applied sciences. Recent efforts have been devoted to the characterization of the resulting ejecta, which consist in a cloud of fine molten droplets. Major difficulties arise from the loss of free surface reflectivity at shock breakout and from the wide distribution of particle velocities within this cloud. We present laser shock experiments on tin and aluminium, to pressures ranging from about 70 to 160 GPa, with complementary diagnostics including a photonic Doppler velocimeter set at a small tilt angle from the normal to the free surface, which enables probing the whole cloud of ejecta. The records are roughly consistent with a one-dimensional theoretical description accounting for laser shock loading, wave propagation, phase transformations, and fragmentation. The main discrepancies between measured and calculated velocity profiles are discussed in terms of edge effects evidenced by transverse shadowgraphy.

  15. Wiskott-Aldrich syndrome in a girl caused by heterozygous WASP mutation and extremely skewed X-chromosome inactivation: a novel association with maternal uniparental isodisomy 6.

    PubMed

    Takimoto, Tomohito; Takada, Hidetoshi; Ishimura, Masataka; Kirino, Makiko; Hata, Kenichiro; Ohara, Osamu; Morio, Tomohiro; Hara, Toshiro

    2015-01-01

    Wiskott-Aldrich syndrome (WAS) is an X-linked disease characterized by microthrombocytopenia, eczema and immune deficiency, caused primarily by mutations in the WASP (Wiskott-Aldrich syndrome protein) gene. Female carriers are usually asymptomatic because of the preferential activation of the normal, nonmutated X-chromosome in their hematopoietic cells. We report our observations of a female child with WAS, who displayed symptoms of congenital thrombocytopenia. DNA sequencing analysis of the WASP gene revealed a heterozygous nonsense mutation in exon 10. The expressions of WASP and normal WASP mRNA were defective. We found preferential inactivation of the X-chromosome on which wild-type WASP was located. Single-nucleotide polymorphism microarray testing and the analysis of the polymorphic variable number of tandem repeat regions revealed maternal uniparental isodisomy of chromosome 6 (UPD6). Our results underscore the importance of WASP evaluation in females with congenital thrombocytopenia and suggest that UPD6 might be related to the pathophysiology of nonrandom X-chromosome inactivation. PMID:25633059

  16. Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic colitis

    PubMed Central

    Diao, Na; Zhang, Yao; Chen, Keqiang; Yuan, Ruoxi; Lee, Christina; Geng, Shuo; Kowalski, Elizabeth; Guo, Wen; Xiong, Huabao; Li, Mingsong; Li, Liwu

    2016-01-01

    Functionally compromised neutrophils contribute to adverse clinical outcomes in patients with severe inflammation and injury such as colitis and sepsis. However, the ontogeny of dysfunctional neutrophil during septic colitis remain poorly understood. We report that the dysfunctional neutrophil may be derived by the suppression of Toll-interacting-protein (Tollip). We observed that Tollip deficient neutrophils had compromised migratory capacity toward bacterial product fMLF due to reduced activity of AKT and reduction of FPR2, reduced potential to generate bacterial-killing neutrophil extra-cellular trap (NET), and compromised bacterial killing activity. On the other hand, Tollip deficient neutrophils had elevated levels of CCR5, responsible for their homing to sterile inflamed tissues. The inflamed and incompetent neutrophil phenotype was also observed in vivo in Tollip deficient mice subjected to DSS-induced colitis. We observed that TUDCA, a compound capable of restoring Tollip cellular function, can potently alleviate the severity of DSS-induced colitis. In humans, we observed significantly reduced Tollip levels in peripheral blood collected from human colitis patients as compared to blood samples from healthy donors. Collectively, our data reveal a novel mechanism in Tollip alteration that underlies the inflamed and incompetent polarization of neutrophils leading to severe outcomes of colitis. PMID:27703259

  17. An exploratory approach demonstrating immune skewing and a loss of coordination among cytokines in plasma and saliva of Veterans with combat-related PTSD.

    PubMed

    Wang, Zhewu; Mandel, Howard; Levingston, Corinne A; Young, M Rita I

    2016-08-01

    Studies have suggested PTSD to be associated with an inflammatory state, although few studies have examined the balances between stimulatory and inhibitory immune mediators in PTSD. An exploratory approach was taken to assess the immune imbalances between Th1 stimulatory, inflammatory and inhibitory mediators associated with PTSD. This approach focused on a tightly-controlled and relatively homogeneous population of Veterans, all with similar levels of combat exposure in the Afghanistan and Iraq wars, but some testing negative and others testing positive for PTSD. Although the sample size was small (6 controls and 7 with PTSD) and a limitation of this study, the results showed significant imbalances in immune cytokines favoring a Th1 and inflammatory state, with reduced levels of inhibitory cytokines in Veterans with PTSD. This was particularly prominent in the saliva of PTSD subjects compared to in their plasma. PMID:27216157

  18. Genetic Basis of Self-Incompatibility in the Lichen-Forming Fungus Lobaria pulmonaria and Skewed Frequency Distribution of Mating-Type Idiomorphs: Implications for Conservation

    PubMed Central

    Singh, Garima; Dal Grande, Francesco; Cornejo, Carolina; Schmitt, Imke; Scheidegger, Christoph

    2012-01-01

    Fungal populations that reproduce sexually are likely to be genetically more diverse and have a higher adaptive potential than asexually reproducing populations. Mating systems of fungal species can be self-incompatible, requiring the presence of isolates of different mating-type genes for sexual reproduction to occur, or self-compatible, requiring only one. Understanding the distribution of mating-type genes in populations can help to assess the potential of self-incompatible species to reproduce sexually. In the locally threatened epiphytic lichen-forming fungus Lobaria pulmonaria (L.) Hoffm., low frequency of sexual reproduction is likely to limit the potential of populations to adapt to changing environmental conditions. Our study provides direct evidence of self-incompatibility (heterothallism) in L. pulmonaria. It can thus be hypothesized that sexual reproduction in small populations might be limited by an unbalanced distribution of mating-type genes. We therefore assessed neutral genetic diversity (using microsatellites) and mating-type ratio in 27 lichen populations (933 individuals). We found significant differences in the frequency of the two mating types in 13 populations, indicating a lower likelihood of sexual reproduction in these populations. This suggests that conservation translocation activities aiming at maximizing genetic heterogeneity in threatened and declining populations should take into account not only presence of fruiting bodies in transplanted individuals, but also the identity and balanced representation of mating-type genes. PMID:23236495

  19. Adjusting skewness and maximum 0.5 hour intensity in CLIGEN to improve extreme event and sub-daily intensity generation for assessing climate change impacts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Both measured data and GCM/RCM projections show an general increasing trend in extreme rainfall events as temperature rises in US. Proper simulation of extreme events is particularly important for assessing climate change impacts on soil erosion and hydrology. The objective of this paper is to fin...

  20. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life

    PubMed Central

    Belderbos, M.E.; van Bleek, G.M.; Levy, O.; Blanken, M.O.; Houben, M.L.; Schuijff, L.; Kimpen, J.L.L.; Bont, L.

    2010-01-01

    Newborns are highly susceptible to infectious diseases, which may be due to impaired immune responses. This study aims to characterize the ontogeny of neonatal TLR-based innate immunity during the first month of life. Cellularity and Toll-like receptor (TLR) agonist-induced cytokine production were compared between cord blood obtained from healthy neonates born after uncomplicated gestation and delivery (n=18), neonatal venous blood obtained at the age of one month (n=96), and adult venous blood (n=17). Cord blood TLR agonist-induced production of the Th1-polarizing cytokines IL-12p70 and IFN-α was generally impaired, but for TLR3, 7 and 9 agonists, rapidly increased to adult levels during the first month of life. In contrast, TLR4 demonstrated a slower maturation, with low LPS-induced IL-12p70 production and high IL-10 production up until the age of one month. Polarization in neonatal cytokine responses to LPS could contribute to neonatal susceptibility to severe bacterial infection. PMID:19648060

  1. Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages.

    PubMed

    Giannoni, Paolo; Pietra, Gabriella; Travaini, Giorgia; Quarto, Rodolfo; Shyti, Genti; Benelli, Roberto; Ottaggio, Laura; Mingari, Maria Cristina; Zupo, Simona; Cutrona, Giovanna; Pierri, Ivana; Balleari, Enrico; Pattarozzi, Alessandra; Calvaruso, Marco; Tripodo, Claudio; Ferrarini, Manlio; de Totero, Daniela

    2014-06-01

    Hepatocyte growth factor, produced by stromal and follicular dendritic cells, and present at high concentrations in the sera of patients with chronic lymphocytic leukemia, prolongs the survival of leukemic B cells by interacting with their receptor, c-MET. It is, however, unknown whether hepatocyte growth factor influences microenvironmental cells, such as nurse-like cells, which deliver survival signals to the leukemic clone. We evaluated the expression of c-MET on nurse-like cells and monocytes from patients with chronic lymphocytic leukemia and searched for phenotypic/functional features supposed to be influenced by the hepatocyte growth factor/c-MET interaction. c-MET is expressed at high levels on nurse-like cells and at significantly higher levels than normal on monocytes from patients. Moreover, the hepatocyte growth factor/c-MET interaction activates STAT3(TYR705) phosphorylation in nurse-like cells. Indoleamine 2,3-dioxygenase, an enzyme modulating T-cell proliferation and induced on normal monocytes after hepatocyte growth factor treatment, was detected together with interleukin-10 on nurse-like cells, and on freshly-prepared patients' monocytes. Immunohistochemical/immunostaining analyses demonstrated the presence of c-MET(+) and indoleamine 2,3-dioxygenase(+) cells in lymph node biopsies, co-expressed with CD68 and vimentin. Furthermore nurse-like cells and chronic lymphocytic monocytes significantly inhibited T-cell proliferation, prevented by anti-transforming growth factor beta and interleukin-10 antibodies and indoleamine 2,3-dioxygenase inhibitors, and supported CD4(+)CD25(high+)/FOXP3(+) T regulatory cell expansion. We suggest that nurse-like cells display features of immunosuppressive type 2 macrophages: higher hepatocyte growth factor levels, produced by leukemic or other microenvironmental surrounding cells, may cooperate to induce M2 polarization. Hepatocyte growth factor may thus have a dual pathophysiological role: directly through enhancement of survival of the leukemic clone and indirectly by favoring T-cell immunosuppression.

  2. Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages

    PubMed Central

    Giannoni, Paolo; Pietra, Gabriella; Travaini, Giorgia; Quarto, Rodolfo; Shyti, Genti; Benelli, Roberto; Ottaggio, Laura; Mingari, Maria Cristina; Zupo, Simona; Cutrona, Giovanna; Pierri, Ivana; Balleari, Enrico; Pattarozzi, Alessandra; Calvaruso, Marco; Tripodo, Claudio; Ferrarini, Manlio; de Totero, Daniela

    2014-01-01

    Hepatocyte growth factor, produced by stromal and follicular dendritic cells, and present at high concentrations in the sera of patients with chronic lymphocytic leukemia, prolongs the survival of leukemic B cells by interacting with their receptor, c-MET. It is, however, unknown whether hepatocyte growth factor influences microenvironmental cells, such as nurse-like cells, which deliver survival signals to the leukemic clone. We evaluated the expression of c-MET on nurse-like cells and monocytes from patients with chronic lymphocytic leukemia and searched for phenotypic/functional features supposed to be influenced by the hepatocyte growth factor/c-MET interaction. c-MET is expressed at high levels on nurse-like cells and at significantly higher levels than normal on monocytes from patients. Moreover, the hepatocyte growth factor/c-MET interaction activates STAT3TYR705 phosphorylation in nurse-like cells. Indoleamine 2,3-dioxygenase, an enzyme modulating T-cell proliferation and induced on normal monocytes after hepatocyte growth factor treatment, was detected together with interleukin-10 on nurse-like cells, and on freshly-prepared patients’ monocytes. Immunohistochemical/immunostaining analyses demonstrated the presence of c-MET+ and indoleamine 2,3-dioxygenase+ cells in lymph node biopsies, co-expressed with CD68 and vimentin. Furthermore nurse-like cells and chronic lymphocytic monocytes significantly inhibited T-cell proliferation, prevented by anti-transforming growth factor beta and interleukin-10 antibodies and indoleamine 2,3-dioxygenase inhibitors, and supported CD4+CD25high+/FOXP3+ T regulatory cell expansion. We suggest that nurse-like cells display features of immunosuppressive type 2 macrophages: higher hepatocyte growth factor levels, produced by leukemic or other microenvironmental surrounding cells, may cooperate to induce M2 polarization. Hepatocyte growth factor may thus have a dual pathophysiological role: directly through enhancement of survival of the leukemic clone and indirectly by favoring T-cell immunosuppression. PMID:24561793

  3. System and method for adaptively deskewing parallel data signals relative to a clock

    DOEpatents

    Jenkins, Philip Nord; Cornett, Frank N.

    2008-10-07

    A system and method of reducing skew between a plurality of signals transmitted with a transmit clock is described. Skew is detected between the received transmit clock and each of received data signals. Delay is added to the clock or to one or more of the plurality of data signals to compensate for the detected skew. The delay added to each of the plurality of delayed signals is updated to adapt to changes in detected skew.

  4. System and method for adaptively deskewing parallel data signals relative to a clock

    DOEpatents

    Jenkins, Philip Nord; Cornett, Frank N.

    2011-10-04

    A system and method of reducing skew between a plurality of signals transmitted with a transmit clock is described. Skew is detected between the received transmit clock and each of received data signals. Delay is added to the clock or to one or more of the plurality of data signals to compensate for the detected skew. The delay added to each of the plurality of delayed signals is updated to adapt to changes in detected skew.

  5. System and method for adaptively deskewing parallel data signals relative to a clock

    DOEpatents

    Jenkins, Philip Nord; Cornett, Frank N.

    2006-04-18

    A system and method of reducing skew between a plurality of signals transmitted with a transmit clock is described. Skew is detected between the received transmit clock and each of received data signals. Delay is added to the clock or to one or more of the plurality of data signals to compensate for the detected skew. Each of the plurality of delayed signals is compared to a reference signal to detect changes in the skew. The delay added to each of the plurality of delayed signals is updated to adapt to changes in the detected skew.

  6. Preference for luminance histogram regularities in natural scenes.

    PubMed

    Graham, Daniel; Schwarz, Bianca; Chatterjee, Anjan; Leder, Helmut

    2016-03-01

    Natural scene luminance distributions typically have positive skew, and for single objects, there is evidence that higher skew is a correlate (but not a guarantee) of glossiness. Skewness is also relevant to aesthetics: preference for glossy single objects (with high skew) has been shown even in infants, and skewness is a good predictor of fruit freshness. Given that primate vision appears to efficiently encode natural scene luminance variation, and given evidence that natural scene regularities may be a prerequisite for aesthetic perception in the spatial domain, here we ask whether humans in general prefer natural scenes with more positively skewed luminance distributions. If humans generally prefer images with the higher-order regularities typical of natural scenes and/or shiny objects, we would expect this to be the case. By manipulating luminance distribution skewness (holding mean and variance constant) for individual natural images, we show that in fact preference varies inversely with increasing positive skewness. This finding holds for: artistic landscape images and calibrated natural scenes; scenes with and without glossy surfaces; landscape scenes and close-up objects; and noise images with natural luminance histograms. Across conditions, humans prefer images with skew near zero over higher skew images, and they prefer skew lower than that of the unmodified scenes. These results suggest that humans prefer images with luminances that are distributed relatively evenly about the mean luminance, i.e., images with similar amounts of light and dark. We propose that our results reflect an efficient processing advantage of low-skew images over high-skew images, following evidence from prior brain imaging results.

  7. Tuning of laser pulse shapes in grating-based compressors for optimal electron acceleration in plasmas

    SciTech Connect

    Toth, Cs.; Faure, J.; van Tilborg, J.; Geddes, C.G.R.; Schroeder, C.B.; Esare y, E.; Leemans, W.P.

    2003-01-22

    The temporal shape (rise time, fall time, skewness) of 50 - 200-fs Ti:sapphire laser pulses has been controlled by appropriate adjustment of a grating-pair compressor. It was found that the skewness of the laser pulse envelope is particularly sensitive to the third-order component of the spectral phase. Introducing such a third-order phase offset by detuning the grating pair relative to the optimum pulse compression settings allowed the generation of skewed pulses. As an example of an application, these skewed pulses were used to optimize a laser-plasma electron accelerator.

  8. Spin-tunnel investigation of a 1/13-scale model of the NASA AD-1 oblique-wing research aircraft

    NASA Technical Reports Server (NTRS)

    White, W. L.; Bowman, J. S., Jr.

    1982-01-01

    The spin and recovery characteristics of a 1/13-scale model of the NASA AD-1 oblique-wing research aircraft at wing-skew positions of 0, 25, 45, and 60 deg (right wing forward) were investigated. Spins were obtained for all wing-skew positions tested. For the unskewed wing position, two spin modes were possible. One spin mode was very steep and recoveries were obtained within 1 turn or less by rudder reversal. The second spin mode was flat and fast; the angle of attack was about 75 deg and the spin rate was about 145 deg/sec (2.5 seconds per turn). For the skewed wing positions, spins were obtained only in the direction of the forward-skewed wing (right wing forward). No spins were obtained to the left when the wing was skewed with the right wing forward. Recoveries should be attempted by deflecting the rudder to full against the spin, the ailerons to full with the spin, and movement of the wings to 0 deg skew. If the wing is skewed, the recovery may not be effected until the wing skew approaches 0 deg.

  9. Weak interactions, omnivory and emergent food-web properties.

    PubMed Central

    Emmerson, Mark; Yearsley, Jon M.

    2004-01-01

    Empirical studies have shown that, in real ecosystems, species-interaction strengths are generally skewed in their distribution towards weak interactions. Some theoretical work also suggests that weak interactions, especially in omnivorous links, are important for the local stability of a community at equilibrium. However, the majority of theoretical studies use uniform distributions of interaction strengths to generate artificial communities for study. We investigate the effects of the underlying interaction-strength distribution upon the return time, permanence and feasibility of simple Lotka-Volterra equilibrium communities. We show that a skew towards weak interactions promotes local and global stability only when omnivory is present. It is found that skewed interaction strengths are an emergent property of stable omnivorous communities, and that this skew towards weak interactions creates a dynamic constraint maintaining omnivory. Omnivory is more likely to occur when omnivorous interactions are skewed towards weak interactions. However, a skew towards weak interactions increases the return time to equilibrium, delays the recovery of ecosystems and hence decreases the stability of a community. When no skew is imposed, the set of stable omnivorous communities shows an emergent distribution of skewed interaction strengths. Our results apply to both local and global concepts of stability and are robust to the definition of a feasible community. These results are discussed in the light of empirical data and other theoretical studies, in conjunction with their broader implications for community assembly. PMID:15101699

  10. Development of Nonword and Irregular Word Lists for Australian Grade 3 Students Using Rasch Analysis

    ERIC Educational Resources Information Center

    Callinan, Sarah; Cunningham, Everarda; Theiler, Stephen

    2014-01-01

    Many tests used in educational settings to identify learning difficulties endeavour to pick up only the lowest performers. Yet these tests are generally developed within a Classical Test Theory (CTT) paradigm that assumes that data do not have significant skew. Rasch analysis is more tolerant of skew and was used to validate two newly developed…

  11. Generating Non-normal Data for Simulation of Structural Equation Models Using Mattson's Method.

    ERIC Educational Resources Information Center

    Reinartz, Werner J.; Echambadi, Raj; Cin, Wynne W.

    2002-01-01

    Tested empirically the applicability of a method developed by S. Mattson for generating data on latent variables with controlled skewness and kurtosis of the observed variables. Monte Carlo simulation results suggest that Mattson's method appears to be a good approach to generate data with defined levels of skewness and kurtosis. (SLD)

  12. Preliminary design of a redundant strapped down inertial navigation unit using two-degree-of-freedom tuned-gimbal gyroscopes

    NASA Technical Reports Server (NTRS)

    1976-01-01

    This redundant strapdown INS preliminary design study demonstrates the practicality of a skewed sensor system configuration by means of: (1) devising a practical system mechanization utilizing proven strapdown instruments, (2) thoroughly analyzing the skewed sensor redundancy management concept to determine optimum geometry, data processing requirements, and realistic reliability estimates, and (3) implementing the redundant computers into a low-cost, maintainable configuration.

  13. Journey to Centers in the Core

    ERIC Educational Resources Information Center

    Groth, Randall E.; Kent, Kristen D.; Hitch, Ebony D.

    2015-01-01

    Considerable discrepancies between the mean and median often occur in data sets that are skewed left, skewed right, or have other unusual features. In such cases, it is important to analyze the data and context carefully to decide how best to describe centers of distributions. The importance of this type of statistical thinking is acknowledged in…

  14. Brief Report: Non-Random X Chromosome Inactivation in Females with Autism

    ERIC Educational Resources Information Center

    Talebizadeh, Z.; Bittel, D. C.; Veatch, O. J.; Kibiryeva, N.; Butler, M. G.

    2005-01-01

    Autism is a heterogeneous neurodevelopmental disorder with a 3-4 times higher sex ratio in males than females. X chromosome genes may contribute to this higher sex ratio through unusual skewing of X chromosome inactivation. We studied X chromosome skewness in 30 females with classical autism and 35 similarly aged unaffected female siblings as…

  15. A Better Lemon Squeezer? Maximum-Likelihood Regression with Beta-Distributed Dependent Variables

    ERIC Educational Resources Information Center

    Smithson, Michael; Verkuilen, Jay

    2006-01-01

    Uncorrectable skew and heteroscedasticity are among the "lemons" of psychological data, yet many important variables naturally exhibit these properties. For scales with a lower and upper bound, a suitable candidate for models is the beta distribution, which is very flexible and models skew quite well. The authors present maximum-likelihood…

  16. Experimental investigation of the noise emission of axial fans under distorted inflow conditions

    NASA Astrophysics Data System (ADS)

    Zenger, Florian J.; Renz, Andreas; Becher, Marcus; Becker, Stefan

    2016-11-01

    An experimental investigation on the noise emission of axial fans under distorted inflow conditions was conducted. Three fans with forward-skewed fan blades and three fans with backward-skewed fan blades and a common operating point were designed with a 2D element blade method. Two approaches were adopted to modify the inflow conditions: first, the inflow turbulence intensity was increased by two different rectangular grids and second, the inflow velocity profile was changed to an asymmetric characteristic by two grids with a distinct bar stacking. An increase in the inflow turbulence intensity affects both tonal and broadband noise, whereas a non-uniform velocity profile at the inlet influences mainly tonal components. The magnitude of this effect is not the same for all fans but is dependent on the blade skew. The impact is greater for the forward-skewed fans than for the backward-skewed and thus directly linked to the fan blade geometry.

  17. Likelihood analysis of asymmetrical mutation bias gradients in vertebrate mitochondrial genomes.

    PubMed Central

    Faith, Jeremiah J; Pollock, David D

    2003-01-01

    Protein-coding genes in mitochondrial genomes have varying degrees of asymmetric skew in base frequencies at the third codon position. The variation in skew among genes appears to be caused by varying durations of time that the heavy strand spends in the mutagenic single-strand state during replication (D(ssH)). The primary data used to study skew have been the gene-by-gene base frequencies in individual taxa, which provide little information on exactly what kinds of mutations are responsible for the base frequency skew. To assess the contribution of individual mutation components to the ancestral vertebrate substitution pattern, here we analyze a large data set of complete vertebrate mitochondrial genomes in a phylogeny-based likelihood context. This also allows us to evaluate the change in skew continuously along the mitochondrial genome and to directly estimate relative substitution rates. Our results indicate that different types of mutation respond differently to the D(ssH) gradient. A primary role for hydrolytic deamination of cytosines in creating variance in skew among genes was not supported, but rather linearly increasing rates of mutation from adenine to hypoxanthine with D(ssH) appear to drive regional differences in skew. Substitutions due to hydrolytic deamination of cytosines, although common, appear to quickly saturate, possibly due to stabilization by the mitochondrial DNA single-strand-binding protein. These results should form the basis of more realistic models of DNA and protein evolution in mitochondria. PMID:14573484

  18. X Chromosome Inactivation in Opioid Addicted Women

    PubMed Central

    Vousooghi, Nasim; Shirazi, Mitra-Sadat Sadat; Goodarzi, Ali; Abharian, Peyman Hassani; Zarrindast, Mohammad-Reza

    2015-01-01

    Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DSM IV criteria for opioid addiction and 30 control females with no known history of addiction were included in the study. Digested and undigested DNA samples which were extracted from blood were analyzed after amplification of the polymorphic androgen receptor (AR) gene located on the X chromosome. XCI skewness was studied in 3 ranges: 50:50–64:36 (random inactivation), 65:35–80:20 (moderately skewed) and >80:20 (highly skewed). Results: XCI from informative females in control group was 63% (N=19) random, 27% (N=8) moderately skewed and 10% (N=3) highly skewed. Addicted women showed 57%, 23% and 20%, respectively. The distribution and frequency of XCI status in women with opioid addiction was not significantly different from control group (P=0.55). Discussion: Our data did not approve our hypothesis of increased XCI skewness among women with opioid addiction or unbalanced (non-random) expression of genes associated with X chromosome in female opioid addicted subjects. PMID:26904175

  19. Near-field shock formation in noise propagation from a high-power jet aircraft.

    PubMed

    Gee, Kent L; Neilsen, Tracianne B; Downing, J Micah; James, Michael M; McKinley, Richard L; McKinley, Robert C; Wall, Alan T

    2013-02-01

    Noise measurements near the F-35A Joint Strike Fighter at military power are analyzed via spatial maps of overall and band pressure levels and skewness. Relative constancy of the pressure waveform skewness reveals that waveform asymmetry, characteristic of supersonic jets, is a source phenomenon originating farther upstream than the maximum overall level. Conversely, growth of the skewness of the time derivative with distance indicates that acoustic shocks largely form through the course of near-field propagation and are not generated explicitly by a source mechanism. These results potentially counter previous arguments that jet "crackle" is a source phenomenon.

  20. Near-field shock formation in noise propagation from a high-power jet aircraft.

    PubMed

    Gee, Kent L; Neilsen, Tracianne B; Downing, J Micah; James, Michael M; McKinley, Richard L; McKinley, Robert C; Wall, Alan T

    2013-02-01

    Noise measurements near the F-35A Joint Strike Fighter at military power are analyzed via spatial maps of overall and band pressure levels and skewness. Relative constancy of the pressure waveform skewness reveals that waveform asymmetry, characteristic of supersonic jets, is a source phenomenon originating farther upstream than the maximum overall level. Conversely, growth of the skewness of the time derivative with distance indicates that acoustic shocks largely form through the course of near-field propagation and are not generated explicitly by a source mechanism. These results potentially counter previous arguments that jet "crackle" is a source phenomenon. PMID:23363199

  1. People Believe That They Are Prototypically Good or Bad

    PubMed Central

    Roy, Michael M.; Liersch, Michael J.; Broomell, Stephen

    2013-01-01

    People have been shown to view their beliefs as being prototypical (modal) but their abilities as (falsely) unique (above or below average). It is possible that these two viewpoints – self as prototypical and self as unique – can be reconciled. If the distribution of ability for a given skill is skewed such that many others have high (low) ability and few others have low (high) ability, it is possible that a majority of peoples’ self-assessments can be above (below) average. Participants in 5 studies demonstrated an understanding that various skills have skewed ability distributions and their self-assessments were related to distribution shape: high when negatively skewed and low when positively skewed. Further, participants tended to place themselves near the mode of their perceived skill distribution. Participants were most likely to think that they were good at skills for which they thought that most others were also good. PMID:24159253

  2. The characterization of radioaerosol deposition in the healthy lung by histogram distribution analysis

    SciTech Connect

    Garrard, C.S.; Gerrity, T.R.; Schreiner, J.F.; Yeates, D.B.

    1981-12-01

    Thirteen healthy nonsmoking volunteers inhaled an 8.1 micrometers (MMAD) radioaerosol on two occasions. Aerosol deposition pattern within the right lung, as recorded by a gamma camera, was expressed as the 3rd and 4th moments of the distribution histogram (skew and kurtosis) of radioactivity during the first ten minutes after aerosol inhalation. Deposition pattern was also expressed as the percentage of deposited activity retained within the lung at 24 hr (24 hr % retention) and found to be significantly correlated with measures of skew (P less than 0.001). Tests of pulmonary function (FEV1, FVC, and MMFR) were significantly correlated with skew. Correlations were also demonstrated for these pulmonary function tests with 24 hr % retention but at lower levels of significance. Results indicate that changes in measures of forced expiratory airflow in healthy human volunteers influence deposition pattern and that the skew of the distribution of inhaled radioactivity may provide an acceptable index of deposition pattern.

  3. The Effects of Race Conditions When Implementing Single-Source Redundant Clock Trees in Triple Modular Redundant Synchronous Architectures

    NASA Technical Reports Server (NTRS)

    Berg, Melanie D.; Kim, Hak S.; Phan, Anthony M.; Seidleck, Christina M.; Label, Kenneth A.; Pellish, Jonathan A.; Campola, Michael J.

    2016-01-01

    We present the challenges that arise when using redundant clock domains due to their time-skew. Radiation data show that a singular clock domain provides an improved triple modular redundant (TMR) scheme over redundant clocks.

  4. Scale Mixture Models with Applications to Bayesian Inference

    NASA Astrophysics Data System (ADS)

    Qin, Zhaohui S.; Damien, Paul; Walker, Stephen

    2003-11-01

    Scale mixtures of uniform distributions are used to model non-normal data in time series and econometrics in a Bayesian framework. Heteroscedastic and skewed data models are also tackled using scale mixture of uniform distributions.

  5. Coulomb corrections to the extrinsic spin-Hall effect of a two-dimensional electron gas

    NASA Astrophysics Data System (ADS)

    Hankiewicz, E. M.; Vignale, G.

    2006-03-01

    We develop the microscopic theory of the extrinsic spin-Hall conductivity of a two-dimensional electron gas, including skew-scattering, side-jump, and Coulomb interaction effects. We find that while the spin-Hall conductivity connected with the side jump is independent of the strength of electron-electron interactions, the skew-scattering term is reduced by the spin-Coulomb drag, so the total spin current and the total spin-Hall conductivity are reduced for typical experimental mobilities. Further, we predict that in paramagnetic systems the spin-Coulomb drag reduces the spin accumulations in two different ways: (i) directly through the reduction of the skew-scattering contribution, and (ii) indirectly through the reduction of the spin diffusion length. Explicit expressions for the various contributions to the spin-Hall conductivity are obtained using an exactly solvable model of the skew scattering.

  6. Susceptibility of Redundant Versus Singular Clock Domains Implemented in SRAM-Based FPGA TMR Designs

    NASA Technical Reports Server (NTRS)

    Berg, Melanie D.; LaBel, Kenneth A.; Pellish, Jonathan

    2016-01-01

    We present the challenges that arise when using redundant clock domains due to their clock-skew. Radiation data show that a singular clock domain (DTMR) provides an improved TMR methodology for SRAM-based FPGAs over redundant clocks.

  7. Restructuring for fault-tolerant systolic arrays

    SciTech Connect

    Li, H.F.; Jayakumar, R.; Lam, C.

    1989-02-01

    The problem of restructuring systolic arrays with faulty cells is considered. An approach to derive the required data flow paths and computational sites is proposed. The data skewing requirement, which must be satisfied to find an input schedule, is also discussed. Algorithms to restructure systolic arrays for three different architecture of the processing elements are presented. A systematic method to retime the restructure array using additional programmable delays so that the retimed array satisfies the data skewing requirement is developed.

  8. Effect of casing treatment on performance of an inlet stage for a transonic multistage compressor

    NASA Technical Reports Server (NTRS)

    Urasek, D. C.; Lewis, G. W., Jr.; Moore, R. D.

    1976-01-01

    An inlet stage of a transonic compressor was tested with three rotor tip casing treatment configurations: blade angle slots, circumferential grooves, and axial skewed slots. Significant increases in both rotor and stage total pressure ratio, total temperature ratio, efficiency, flow range, and very large improvements in stall margin were obtained with all three casing treatment configurations. The greatest improvement in performance was achieved with axial skewed slots.

  9. Uncertainty relation of mixed states by means of Wigner-Yanase-Dyson information

    SciTech Connect

    Li, D.; Li, X.; Wang, F.; Huang, H.; Li, X.; Kwek, L. C.

    2009-05-15

    The variance of an observable in a quantum state is usually used to describe Heisenberg uncertainty relation. For mixed states, the variance includes quantum and classical uncertainties. By means of the skew information and the decomposition of the variance, a stronger uncertainty relation was presented by Luo [ Phys. Rev. A 72, 042110 (2005)]. In this paper, by using Wigner-Yanase-Dyson information which is a generalization of the skew information, we propose a general uncertainty relation of mixed states.

  10. On the observation of multiple volume reflection from different planes inside one bent crystal

    SciTech Connect

    Guidi, Vincenzo; Mazzolari, Andrea; Tikhomirov, Victor

    2010-06-15

    An interpretation of the first experiment on the observation of 400 GeV proton multiple volume reflection from different skew planes of one bent crystal (MVROC) is given. The possibilities of experimental observation of MVROC at lower particle energies are demonstrated. New features of the effect of particle capture into the channeling regime by bent skew planes are revealed as well as optimal choice of main crystal axis, crystal thickness, and beam orientation with respect to the crystal is discussed.

  11. Choosing the Best Correction Formula for the Pearson r[superscript 2] Effect Size

    ERIC Educational Resources Information Center

    Skidmore, Susan Troncoso; Thompson, Bruce

    2011-01-01

    In the present Monte Carlo simulation study, the authors compared bias and precision of 7 sampling error corrections to the Pearson r[superscript 2] under 6 x 3 x 6 conditions (i.e., population ρ values of 0.0, 0.1, 0.3, 0.5, 0.7, and 0.9, respectively; population shapes normal, skewness = kurtosis = 1, and skewness = -1.5 with kurtosis = 3.5;…

  12. A Mixed Gamma ARMA(1, 1) Model for River Flow Time Series

    NASA Astrophysics Data System (ADS)

    Sim, C. H.

    1987-01-01

    In this paper we consider a time series model which can easily be used for simulating stationary river flow sequences with high skewness and the long-term correlation structure of an ARMA(1, 1) model. The model is fitted to monthly streamflows taken from a river in Malaysia. The simulated data bear a close resemblance to the historical sequence in terms of the mean, variance, skewness, and autocorrelation coefficients.

  13. Binomial and Poisson Mixtures, Maximum Likelihood, and Maple Code

    SciTech Connect

    Bowman, Kimiko o; Shenton, LR

    2006-01-01

    The bias, variance, and skewness of maximum likelihoood estimators are considered for binomial and Poisson mixture distributions. The moments considered are asymptotic, and they are assessed using the Maple code. Question of existence of solutions and Karl Pearson's study are mentioned, along with the problems of valid sample space. Large samples to reduce variances are not unusual; this also applies to the size of the asymptotic skewness.

  14. Structure determination of propanal by joint analysis of gas electron diffraction, microwave and infrared spectroscopy, including constraints and a valence force field from geometry relaxed ab-initio calculations

    NASA Astrophysics Data System (ADS)

    Van Nuffel, P.; Van Den Enden, L.; Van Alsenoy, C.; Geise, H. J.

    1984-04-01

    The structure and conformational equilibrium of CH 3-SYN and CH 3-SKEW conformers of propanal were studied by joint analysis of gas electron diffraction, microwave and infrared data, including constraints obtained after ab-initio relaxations (4-21G basis set) of the molecule. A valence force field was calculated for both conformers and scaled upon experimental IR frequencies; theoretical frequencies and band intensities are compared to experimental ones. Rotamer populations of CH 3-SYN and CH 3-SKEW were found to be 81 and 19%, respectively, at 300 K. The following best-fitting rg/ rα parameters were obtained as: r(OC) = 1.209(4) Å, r(C2C3) = 1.515(9) Å, r(C3C4) = 1.521(9) Å for CH 3-SYN and (with lower reliability) 1.569(45) Å for CH 3-SKEW, = 1.127(4) Å, ∠O=CC = 124.5(3)°(SYN) and 125.1(3)° (SKEW), ∠CCC = 113.8(4)° (SYN) and 110.2(4)° (SKEW), torsion angle around C2C3 = 123.7(2.6)° for CH 3-SKEW.

  15. Direct Measurement of Planar Flow Rate in Excised Canine Larynx Model

    PubMed Central

    Oren, Liran; Khosla, Sid; Dembinski, Doug; Ying, Jun; Gutmark, Ephraim

    2014-01-01

    Objective During phonation, skewing of the glottal flow waveform (Q) during phonation refers to a phenomenon that occurs when the flow decelerates more rapidly than it accelerates. This skewing is clinically important because it increases the glottal efficiency, which is defined by the acoustic intensity (units are sound pressure level or SPL) divided by the subglottal pressure. Current theoretical models predict that the only mechanism to cause skewing of Q involves changes in the vocal tract inertance. The purpose of the current work is to show that other factors at the vocal fold level can also cause skewing of Q and to determine if the acoustic intensity is correlated with MFDR. Study design Basic Science Methods Intraglottal geometry and velocity measurements were taken in five canine larynges at the mid-membranous plane using two-dimensional particle imaging velocimetry (PIV). The flow rate at the glottal exit was computed from the PIV measurements for low, medium, and high subglottal pressures. Results Vortices form in the superior aspect of the divergent glottis during closing. These vortices produce negative pressure that increases both the maximum value of Q and the rapid deceleration of the flow. The skewing of the flow rate is increased as the intraglottal vortices are increased by increasing the subglottal pressure. The increase in the acoustic intensity is highly correlated with certain properties of the flow rate waveform, such as maximum flow rate. Conclusion Flow skewing and the acoustic intensity can be increased by increasing the intraglottal vortices. PMID:25093928

  16. X-CHROMOSOME INACTIVATION PATTERNS IN MONOZYGOTIC TWINS AND SIB PAIRS DISCORDANT FOR NON-SYNDROMIC CLEFT LIP AND/OR PALATE

    PubMed Central

    Kimani, Jane W.; Shi, Min; Daack-Hirsch, Sandra; Christensen, Kaare; Moretti-Ferreira, Danilo; Marazita, Mary L.; Field, Leigh L.; Canady, John W.; Murray, Jeffrey C.

    2009-01-01

    Background Orofacial clefts are common birth defects with a complex etiology. While underlying mechanisms are still largely unknown, altered gender ratios for clefting phenotypes, evidence for linkage to the X chromosome and the occurrence of several X-linked clefting syndromes suggest that skewed X chromosome inactivation (XCI) may contribute to the etiology of orofacial clefting. We tested this hypothesis in a sample set of female monozygotic (MZ) twins and sister pairs discordant for clefting. Methods We determined XCI in peripheral blood lymphocyte DNA using a methylation based androgen receptor gene assay. We measured skewing of XCI as the deviation in XCI pattern from a 50:50 ratio and used a paired t-test to compare the degree of skewing in cases and their unaffected sisters. Results Our analysis revealed no significant difference in the degree of skewing between twin pairs (P=0.3). However, significant differences were observed in the sister pairs (P=0.02), with the cleft lip with cleft palate (CL+P) group showing the most significant result (P=0.01). Results from the cleft lip only (P=0.79) and cleft palate only (P=0.75) groups were not significant. Conclusions We did not find evidence for involvement of skewed XCI in the discordance for clefting in our sample of female MZ twins. However, results from the paired sister study suggest that skewed XCI may be important in orofacial clefting, particularly CL+P. PMID:18000982

  17. A Deeper Statistical Examination of Arrival Dates of Migratory Breeding Birds in Relation to Global Climate Change

    PubMed Central

    Wilson, W. Herbert

    2013-01-01

    Using an 18-year dataset of arrival dates of 65 species of Maine migratory breeding birds, I take a deeper view of the data to ask questions about the shapes of the distribution. For each year, most species show a consistent right-skewed pattern of distribution, suggesting that selection is stronger against individuals that arrive too early compared to those that arrive later. Distributions are consistently leptokurtic, indicating a narrow window of optimal arrival dates. Species that arrive earlier in the spring show higher skewness and kurtosis values. Nectarivorous species showed more pronounced skewness. Wintering area did not explain patterns of skewness or kurtosis. Deviations from average temperatures and the North Atlantic Oscillation index explained little variation in skewness and kurtosis. When arrival date distributions are broken down into different medians (e.g., 5% median and 75% median), stronger correlations emerge for portions of the distribution that are adjacent, suggesting species fine-tune the progress of their migration. Interspecific correlations for birds arriving around the same time are stronger for earliest migrants (the 25% median) compared to the true median and the 75% median. PMID:24832806

  18. Influence of particle size distribution on random close packing of spheres.

    PubMed

    Desmond, Kenneth W; Weeks, Eric R

    2014-08-01

    The densest amorphous packing of rigid particles is known as random close packing. It has long been appreciated that higher densities are achieved by using collections of particles with a variety of sizes. For spheres, the variety of sizes is often quantified by the polydispersity of the particle size distribution: the standard deviation of the radius divided by the mean radius. Several prior studies quantified the increase of the packing density as a function of polydispersity. A particle size distribution is also characterized by its skewness, kurtosis, and higher moments, but the influence of these parameters has not been carefully quantified before. In this work, we numerically generate many sphere packings with different particle radii distributions, varying polydispersity and skewness independently of one another. We find that the packing density can increase significantly with increasing skewness and in some cases skewness can have a larger effect than polydispersity. However, the packing fraction is relatively insensitive to the higher moment value of the kurtosis. We present a simple empirical formula for the value of the random close packing density as a function of polydispersity and skewness.

  19. Seasonality of submesoscale flows in the ocean surface boundary layer

    NASA Astrophysics Data System (ADS)

    Buckingham, Christian E.; Naveira Garabato, Alberto C.; Thompson, Andrew F.; Brannigan, Liam; Lazar, Ayah; Marshall, David P.; George Nurser, A. J.; Damerell, Gillian; Heywood, Karen J.; Belcher, Stephen E.

    2016-03-01

    A signature of submesoscale flows in the upper ocean is skewness in the distribution of relative vorticity. Expected to result for high Rossby number flows, such skewness has implications for mixing, dissipation, and stratification within the upper ocean. An array of moorings deployed in the Northeast Atlantic for 1 year as part of the experiment of the Ocean Surface Mixing, Ocean Submesoscale Interaction Study (OSMOSIS) reveals that relative vorticity is positively skewed during winter even though the scale of the Rossby number is less than 0.5. Furthermore, this skewness is reduced to zero during spring and autumn. There is also evidence of modest seasonal variations in the gradient Rossby number. The proposed mechanism by which relative vorticity is skewed is that the ratio of lateral to vertical buoyancy gradients, as summarized by the inverse gradient Richardson number, restricts its range during winter but less so at other times of the year. These results support recent observations and model simulations suggesting that the upper ocean is host to a seasonal cycle in submesoscale turbulence.

  20. Quantum diagrammatic theory of the extrinsic spin Hall effect in graphene

    NASA Astrophysics Data System (ADS)

    Milletarı, Mirco; Ferreira, Aires

    2016-10-01

    We present a rigorous microscopic theory of the extrinsic spin Hall effect in disordered graphene based on a nonperturbative quantum diagrammatic treatment incorporating skew scattering and anomalous (impurity-concentration-independent) quantum corrections on equal footing. The leading skew-scattering contribution to the spin Hall conductivity is shown to quantitatively agree with Boltzmann transport theory over a wide range of parameters. Our self-consistent approach, where all topologically equivalent noncrossing diagrams are resummed, unveils that the skewness generated by spin-orbit-active impurities deeply influences the anomalous component of the spin Hall conductivity, even in the weak-scattering regime. This seemingly counterintuitive result is explained by the rich sublattice structure of scattering potentials in graphene, for which traditional Gaussian disorder approximations fail to capture the intricate correlations between skew scattering and side jumps generated through diffusion. Finally, we assess the role of quantum interference corrections by evaluating an important subclass of crossing diagrams recently considered in the context of the anomalous Hall effect, the X and Ψ diagrams [A. Ado et al., Europhys. Lett. 111, 37004 (2015), 10.1209/0295-5075/111/37004]. We show that Ψ diagrams, encoding quantum coherent skew scattering, display a strong Fermi energy dependence, dominating the anomalous spin Hall component away from the Dirac point. Our findings have direct implications for nonlocal transport experiments in spin-orbit-coupled graphene systems.

  1. Data acquisition techniques for exploiting the uniqueness of the time-of-flight mass spectrometer: Application to sampling pulsed gas systems

    NASA Technical Reports Server (NTRS)

    Lincoln, K. A.

    1980-01-01

    Mass spectra are produced in most mass spectrometers by sweeping some parameter within the instrument as the sampled gases flow into the ion source. It is evident that any fluctuation in the gas during the sweep (mass scan) of the instrument causes the output spectrum to be skewed in its mass peak intensities. The time of flight mass spectrometer (TOFMS) with its fast, repetitive mode of operation produces spectra without skewing or varying instrument parameters and because all ion species are ejected from the ion source simultaneously, the spectra are inherently not skewed despite rapidly changing gas pressure or composition in the source. Methods of exploiting this feature by utilizing fast digital data acquisition systems, such as transient recorders and signal averagers which are commercially available are described. Applications of this technique are presented including TOFMS sampling of vapors produced by both pulsed and continuous laser heating of materials.

  2. Effects of asymmetry on the dynamic stability of aircraft

    NASA Technical Reports Server (NTRS)

    Fantino, R. E.; Parsons, E. K.; Powell, J. D.; Shevell, R. S.

    1975-01-01

    The oblique wing concept for transonic aircraft was proposed to reduce drag. The dynamic stability of the aircraft was investigated by analytically determining the stability derivatives at angles of skew ranging from 0 and 45 deg and using these stability derivatives in a linear analysis of the coupled aircraft behavior. The stability derivatives were obtained using a lifting line aerodynamic theory and found to give reasonable agreement with derivatives developed in a previous study for the same aircraft. In the dynamic analysis, no instability or large changes occurred in the root locations for skew angles varying from 0 to 45 deg with the exception of roll convergence. The damping in roll, however, decreased by an order of magnitude. Rolling was a prominent feature of all the oscillatory mode shapes at high skew angles.

  3. Design of supersonic Coanda jet nozzles

    NASA Technical Reports Server (NTRS)

    Bevilaqua, Paul M.; Lee, John D.

    1987-01-01

    The thrust vectoring of supersonic Coanda jets was improved by designing a nozzle to skew the initial jet velocity profile. A new nozzle design procedure, based on the method of characteristics, was developed to design a nozzle which produces a specified exit velocity profile. The thrust vectoring of a simple convergent nozzle, a convergent-divergent nozzle, and a nozzle which produces a skewed velocity profile matched to the curvature of the Coanda surface were expermentially compared over a range of pressure ratios from 1.5 to 3.5. Elimination of the expansion shocks with the C-D nozzle is shown to greatly improve the thrust vectoring; elimination of turning shocks with the skewed profile nozzle further improves the vectoring.

  4. Application of carrier testing to genetic counseling for X-linked agammaglobulinemia

    SciTech Connect

    Allen, R.C.; Nachtman, R.G.; Belmont, J.W.; Rosenblatt, H.M.

    1994-01-01

    Bruton X-linked agammaglobulinemia (XLA) is a phenotypically recessive genetic disorder of B lymphocyte development. Female carriers of XLA, although asymptomatic, have a characteristic B cell lineage-specific skewing of the pattern of X inactivation. Skewing apparently results from defective growth and maturation of B cell precursors bearing a mutant active X chromosome. In this study, carrier status was tested in 58 women from 22 families referred with a history of agammaglobulinemia. Primary carrier analysis to examine patterns of X inactivation in CD19[sup +] peripheral blood cells (B lymphocytes) was conducted using quantitative PCR at the androgen-receptor locus. Obligate carriers of XLA demonstrated >95% skewing of X inactivation in peripheral blood CD19[sup +] cells but not in CD19[sup [minus

  5. COUPLING MEASUREMENT AND CORRECTION AT RHIC.

    SciTech Connect

    PILAT,F.; BEEBE-WANG,J.; FISCHER,W.; PTITSYN,V.; SATOGATA,T.

    2002-06-02

    Coupling correction at RHIC has been operationally achieved through a two-step process: using local triplet skew quadrupoles to compensate coupling corn rolled low-beta triplet quadrupoles, and minimizing the tune separation and residual coupling with orthogonal global skew quadrupole families. An application has been developed for global correction that allows skew quadrupole tuning and tune display with a choice of different tune measurement techniques, including tune-meter, Schottky and phase lock loop (PLL). Coupling effects have been analysed by using 1024-turn (TBT) information from the beam position monitor (BPM) system. These data allow the reconstruction of the off-diagonal terms of the transfer matrix, a measure of global coupling. At both injection and storage energies, coordination of tune meter kicks with TBT acquisition at 322 BPM's in each ring allows the measurement of local coupling at all BPM locations.

  6. RESEARCH NOTE FROM COLLABORATION: Observability of bbZ events at CMS as a benchmark for MSSM bbH search

    NASA Astrophysics Data System (ADS)

    Lehti, S.

    2007-04-01

    The Z boson production in association with two b quarks is studied as a benchmark for MSSM \\rm b\\skew{-4}\\barbH production with H → ττ decay in CMS. An analysis using Z bosons in real data can be used to test the methods and techniques needed for reconstructing the Higgs boson. The \\rm b\\skew{-4}\\barbZ measured from data can be used to verify the theoretical predictions for the cross section, and Z boson and b quark transverse momentum distributions. Understanding the \\rm b\\skew{-4}\\barbZ production at LHC helps us to understand and better trust the predictions for the associated Higgs bosons production.

  7. Best Alternatives to Cronbach's Alpha Reliability in Realistic Conditions: Congeneric and Asymmetrical Measurements

    PubMed Central

    Trizano-Hermosilla, Italo; Alvarado, Jesús M.

    2016-01-01

    The Cronbach's alpha is the most widely used method for estimating internal consistency reliability. This procedure has proved very resistant to the passage of time, even if its limitations are well documented and although there are better options as omega coefficient or the different versions of glb, with obvious advantages especially for applied research in which the ítems differ in quality or have skewed distributions. In this paper, using Monte Carlo simulation, the performance of these reliability coefficients under a one-dimensional model is evaluated in terms of skewness and no tau-equivalence. The results show that omega coefficient is always better choice than alpha and in the presence of skew items is preferable to use omega and glb coefficients even in small samples. PMID:27303333

  8. Programmable Differential Delay Circuit With Fine Delay Adjustment

    DOEpatents

    DeRyckere, John F.; Jenkins, Philip Nord; Cornett, Frank Nolan

    2002-07-09

    Circuitry that provides additional delay to early arriving signals such that all data signals arrive at a receiving latch with same path delay. The delay of a forwarded clock reference is also controlled such that the capturing clock edge will be optimally positioned near quadrature (depending on latch setup/hold requirements). The circuitry continuously adapts to data and clock path delay changes and digital filtering of phase measurements reduce errors brought on by jittering data edges. The circuitry utilizes only the minimum amount of delay necessary to achieve objective thereby limiting any unintended jitter. Particularly, this programmable differential delay circuit with fine delay adjustment is designed to allow the skew between ASICS to be minimized. This includes skew between data bits, between data bits and clocks as well as minimizing the overall skew in a channel between ASICS.

  9. Effects of triggering mechanism on snow avalanche slope angles and slab depths from field data

    NASA Astrophysics Data System (ADS)

    McClung, David M.

    2013-04-01

    Field data from snow avalanche fracture lines for slope angle and slab depth (measured perpendicular to the weak layer) were analyzed for different triggering mechanisms. For slope angle, the results showed that the same probability density function (pdf) (of log-logistic type) and range (25 - 55 degrees) apply independent of triggering mechanism. For slab depth, the same pdf (generalized extreme value) applies independent of triggering mechanism. For both slope angle and slab depth, the data skewness differentiated between triggering mechanism and increased with applied triggering load. For slope angle, skewness is lowest for natural triggering by snow loads and highest for triggering from human intervention. For slab depth, the skewness is lowest for natural triggering and highest for a mix of triggers including explosive control with skier triggering being intermediate. The results reveal the effects of triggering mechanism which are important for risk analyses and to guide avalanche forecasting.

  10. Molecular events by which dendritic cells promote Th2 immune protection in helmith infection.

    PubMed

    Méndez-Samperio, Patricia

    2016-10-01

    Helminth parasites are a major cause of global infectious diseases, affecting nearly one quarter of the world's population. The common feature of helminth infections is to skew the immune system towards a T-helper 2 (Th2) response that helps to control disease. Dendritic cells (DCs), which are professional antigen-presenting cells, play a critical role for Th2 skewing against helminth parasites. However, the molecular mechanisms by which helminth antigens activate DCs for Th2 polarization have not yet been clearly defined. This review provides a focused update on the major role of DCs for inducing and/or enhancing Th2 immune responses in helminthic infection and will discuss the main signalling-dependent and independent mechanisms by which helminth antigens activate DCs for Th2 skewing. PMID:27348757

  11. Nonsinusoidal Current-Phase Relationship in Josephson Junctions from the 3D Topological Insulator HgTe

    NASA Astrophysics Data System (ADS)

    Sochnikov, Ilya; Maier, Luis; Watson, Christopher A.; Kirtley, John R.; Gould, Charles; Tkachov, Grigory; Hankiewicz, Ewelina M.; Brüne, Christoph; Buhmann, Hartmut; Molenkamp, Laurens W.; Moler, Kathryn A.

    2015-02-01

    We use superconducting quantum interference device microscopy to characterize the current-phase relation (CPR) of Josephson junctions from the three-dimensional topological insulator HgTe (3D HgTe). We find clear skewness in the CPRs of HgTe junctions ranging in length from 200 to 600 nm. The skewness indicates that the Josephson current is predominantly carried by Andreev bound states with high transmittance, and the fact that the skewness persists in junctions that are longer than the mean free path suggests that the effect may be related to the helical nature of the Andreev bound states in the surface of HgTe. These experimental results suggest that the topological properties of the normal state can be inherited by the induced superconducting state, and that 3D HgTe is a promising material for realizing the many exciting proposals that require a topological superconductor.

  12. Re-visit local coupling correction in the interaction regions of RHIC

    SciTech Connect

    Luo, Y.; Fischer, W.; Liu, C.; Marusic, A.; Minty, M.; Ptitsyn, V.; Schoefer, V.; Tepikian, S.; Trbojevic, D.; Zimmer, C.

    2011-11-01

    In this article we will re-visit the local coupling correction in the interaction regions (IRs) of the Relativistic Heavy Ion Collider (RHIC). We will review the measurement data of triplet quadrupole rolls, the local coupling correction strengths in the RHIC control system, and the methods for the local coupling correction with local skew quadrupole correctors. Based on the in-turnnel measurement data of triplet roll errors in 2011, we will analytically calculate and simulate IR-bump method to find out the local skew correction strengths and compare them at store and at injection with the Blue and Yellow ring lattices in the 2011 polarized proton (p-p) and Au-Au runs. The vertical dispersion from the triplet roll errors, local and global coupling correction skew quadrupoles, and the vertical dipole correctors are calculated and discussed.

  13. Techniques for estimating peak-flow frequency relations for North Dakota streams

    USGS Publications Warehouse

    Williams-Sether, Tara

    1992-01-01

    This report presents techniques for estimating peak-flow frequency relations for North Dakota streams. In addition, a generalized skew coefficient analysis was completed for North Dakota to test the validity of using the generalized skew coefficient map in Bulletin 17B of the Hydrology Subcommittee of the Interagency Advisory Committee on Water Data, 1982, 'Guidelines for Determining Flood Flow Frequency.' The analysis indicates that the generalized skew coefficient map in Bulletin 17B provides accurate estimates of generalized skew coefficient values for natural-flow streams in North Dakota. Peak-flow records through 1988 for 192 continuous- and partial-record streamflow gaging stations that had 10 or more years of record were used in a generalized least-squares regression analysis that relates peak flows for selected recurrence intervals to selected basin characteristics. Peak-flow equations were developed for recurrence intervals of 2, 10, 15, 25, 50, 100, and 500 years for three hydrologic regions in North Dakota. The peak-flow equations are applicable to natural-flow streams that have drainage areas of less than or equal to 1,000 square miles. The standard error of estimate for the three hydrologic regions ranges from 60 to 70 percent for the 100-year peak-flow equations. Methods are presented for transferring peak-flow data from gaging stations to ungaged sites on the same stream and for determining peak flows for ungaged sites on ungaged streams. Peak-flow relations, weighted estimates of peak flow, and selected basin characteristics are tabulated for the 192 gaging stations used in the generalized skew coefficient and regression analyses. Peak-flow relations also are provided for 63 additional gaging stations that were not used in the generalized skew coefficient and regression analyses. These 63 gaging stations generally represent streams that are significantly controlled by regulation and those that have drainage areas greater than 1,000 square miles.

  14. Modelling non-Gaussianity of background and observational errors by the Maximum Entropy method

    NASA Astrophysics Data System (ADS)

    Pires, Carlos; Talagrand, Olivier; Bocquet, Marc

    2010-05-01

    The Best Linear Unbiased Estimator (BLUE) has widely been used in atmospheric-oceanic data assimilation. However, when data errors have non-Gaussian pdfs, the BLUE differs from the absolute Minimum Variance Unbiased Estimator (MVUE), minimizing the mean square analysis error. The non-Gaussianity of errors can be due to the statistical skewness and positiveness of some physical observables (e.g. moisture, chemical species) or due to the nonlinearity of the data assimilation models and observation operators acting on Gaussian errors. Non-Gaussianity of assimilated data errors can be justified from a priori hypotheses or inferred from statistical diagnostics of innovations (observation minus background). Following this rationale, we compute measures of innovation non-Gaussianity, namely its skewness and kurtosis, relating it to: a) the non-Gaussianity of the individual error themselves, b) the correlation between nonlinear functions of errors, and c) the heteroscedasticity of errors within diagnostic samples. Those relationships impose bounds for skewness and kurtosis of errors which are critically dependent on the error variances, thus leading to a necessary tuning of error variances in order to accomplish consistency with innovations. We evaluate the sub-optimality of the BLUE as compared to the MVUE, in terms of excess of error variance, under the presence of non-Gaussian errors. The error pdfs are obtained by the maximum entropy method constrained by error moments up to fourth order, from which the Bayesian probability density function and the MVUE are computed. The impact is higher for skewed extreme innovations and grows in average with the skewness of data errors, especially if those skewnesses have the same sign. Application has been performed to the quality-accepted ECMWF innovations of brightness temperatures of a set of High Resolution Infrared Sounder channels. In this context, the MVUE has led in some extreme cases to a potential reduction of 20-60% error

  15. Making Nozzles From Hard Materials

    NASA Technical Reports Server (NTRS)

    Wells, Dennis L.

    1989-01-01

    Proposed method of electrical-discharge machining (EDM) cuts hard materials like silicon carbide into smoothly contoured parts. Concept developed for fabrication of interior and exterior surfaces and internal cooling channels of convergent/divergent nozzles. EDM wire at skew angle theta creates hyperboloidal cavity in tube. Wire offset from axis of tube and from axis of rotation by distance equal to throat radius. Maintaining same skew angle as that used to cut hyperboloidal inner surface but using larger offset, cooling channel cut in material near inner hyperboloidal surface.

  16. Observation of nonsinusoidal current-phase relation in graphene Josephson junctions

    NASA Astrophysics Data System (ADS)

    English, C. D.; Hamilton, D. R.; Chialvo, C.; Moraru, I. C.; Mason, N.; Van Harlingen, D. J.

    2016-09-01

    The current-phase relation of a Josephson junction can reveal valuable information about the processes influencing the supercurrent. In this paper we present direct measurements of the current-phase relation for Josephson junctions having a graphene barrier, obtained by a phase-sensitive SQUID interferometry technique. We find that the current-phase relation is forward skewed with respect to the commonly observed sinusoidal behavior for short junctions in the quasiballistic transport regime, consistent with predictions for the behavior of Dirac fermions in a Josephson junction. The skewness increases with critical current and decreases sharply with increasing temperature.

  17. The LaueUtil toolkit for Laue photocrystallography. II. Spot finding and integration

    SciTech Connect

    Kalinowski, Jaroslaw A.; Fournier, Bertrand; Makal, Anna; Coppens, Philip

    2015-10-15

    A spot-integration method is described which does not require prior indexing of the reflections. It is based on statistical analysis of the values from each of the pixels on successive frames, followed for each frame by morphological analysis to identify clusters of high value pixels which form an appropriate mask corresponding to a reflection peak. The method does not require prior assumptions such as fitting of a profile or definition of an integration box. The results are compared with those of the seed-skewness method which is based on minimizing the skewness of the intensity distribution within a peak's integration box. Applications in Laue photocrystallography are presented.

  18. Experimental research on secondary flows in annular turbine cascades at the Von Karman Institute

    NASA Astrophysics Data System (ADS)

    Boletis, E.

    Investigations of secondary flows in isolated annular cascades with collateral inlet boundary layers; in an annular turbine nozzle guide vane followed by a rotating blade row; in isolated annular cascades with skewed inlet boundary layers; and in a turbine stator preceded by a full stage are summarized. Secondary flow patterns in annular configurations, e.g., the mutual interference of the passage vortices and the radial pressure gradient, the radial migration of low momentum material, effects of tip contouring inlet skew are studied. Differences between the flow field in annular and straight cascades can be derived from comparison with other test results.

  19. Level II scour analysis for Bridge 28 (BRNATH00660028) on Town Highway 66, crossing Locust Creek, Barnard, Vermont

    USGS Publications Warehouse

    Severence, Timothy

    1997-01-01

    The Town Highway 66 crossing of the Locust Creek is a 41-ft-long, one-lane bridge consisting of a 39 ft steel stringer type bridge with a concrete deck (Vermont Agency of Transportation, written communication, August 24, 1994). The clear span is 36.8 ft. The bridge is supported by vertical, concrete abutments with wingwalls. The upstream right wingwall is protected by stone fill. The channel is skewed approximately 10 degrees to the opening while the opening-skew-to-roadway is 0 degrees. Additional details describing conditions at the site are included in the Level II Summary and Appendices D and E.

  20. Noncommutative Pfaffians associated with the orthogonal algebra

    SciTech Connect

    Artamonov, Dmitrii V; Golubeva, Valentina A

    2012-12-31

    Commutators of Pfaffians associated with the orthogonal algebra are found in skew-symmetric and root realizations of o{sub N}. A generating function of Pfaffians is proved to satisfy the reflection equation. A relation between Pfaffians in skew-symmetric and root realizations of o{sub N} is established. Using these results we construct an integrable equation of Knizhnik-Zamolodchikov type using the Capelli central elements in U(o{sub N}), which are sums of squares of the considered Pfaffians. A classical limit of the obtained Knizhnik-Zamolodchikov type equation turns out to be a very specific system of equations of isomonodromic deformations. Bibliography: 18 titles.