[Skiing accidents in children (author's transl)].

PubMed

Schwarzenbach, M; Röthlisberger, M; Herwig, K; Biener, K

1981-03-13

In Arosa, a coherent skiing arena, all skiing accidents were systemically recorded by the two general practitioners for 10 years. The incidence of accidents to children compared with that of adolescents and adults was of particular interest. The incidence of accidents to children has more markedly decreased. The frequency of collisions is increasing. The most common injuries to children are fractures, followed by sprains and contusions. On the other hand sprains are the most common injury to adolescents and adults, followed by fractures and an almost equal number of contusions. The dangers of skiing and the severity of the injuries are discussed. Demands are made for prevention of skiing accidents.

Sports injuries and illnesses in the Sochi 2014 Olympic Winter Games.

PubMed

Soligard, Torbjørn; Steffen, Kathrin; Palmer-Green, Debbie; Aubry, Mark; Grant, Marie-Elaine; Meeuwisse, Willem; Mountjoy, Margo; Budgett, Richard; Engebretsen, Lars

2015-04-01

Systematic surveillance of injuries and illnesses is the foundation for developing preventive measures in sport. To analyse the injuries and illnesses that occurred during the XXII Olympic Winter Games, held in Sochi in 2014. We recorded the daily occurrence (or non-occurrence) of injuries and illnesses (1) through the reporting of all National Olympic Committee (NOC) medical teams and (2) in the polyclinic and medical venues by the Sochi 2014 medical staff. NOC and Sochi 2014 medical staff reported 391 injuries and 249 illnesses among 2780 athletes from 88 NOCs, equalling incidences of 14 injuries and 8.9 illnesses per 100 athletes over an 18-day period of time. Altogether, 12% and 8% of the athletes incurred at least one injury or illness, respectively. The percentage of athletes injured was highest in aerial skiing, snowboard slopestyle, snowboard cross, slopestyle skiing, halfpipe skiing, moguls skiing, alpine skiing, and snowboard halfpipe. Thirty-nine per cent of the injuries were expected to prevent the athlete from participating in competition or training. Women suffered 50% more illnesses than men. The rate of illness was highest in skeleton, short track, curling, cross-country skiing, figure skating, bobsleigh and aerial skiing. A total of 159 illnesses (64%) affected the respiratory system, and the most common cause of illness was infection (n=145, 58%). Overall, 12% of the athletes incurred at least one injury during the games, and 8% an illness, which is similar to prior Olympic Games. The incidence of injuries and illnesses varied substantially between sports. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

[Changes in skiing accidents during the last 20 years].

PubMed

Röthlisberger, M

1990-01-01

Since 23 years the skiing-accidents are statistically surveyed in the private practice of the author. The number of injured patients is continuously decreasing. Specially the injuries in years with little snow fall are analyzed. It is evident that leg fractures are quite rare but severe injuries of the knee are increasing. 50% of ski accidents are minor injuries.

Safety knowledge and risk behaviour of injured and uninjured young skiers and snowboarders

PubMed Central

Macnab, Andrew J; Cadman, Robert E; Greenlaw, Julia V

1998-01-01

BACKGROUND: Earlier studies of ski injury indicated that youths were at increased risk of injury, that males were most likely to injure the head or face, and that females were most likely to injure the knee. OBJECTIVE: To obtain information about safety knowledge and risk behaviour that might contribute to injury among young skiers and snow-boarders. DESIGN: Survey of knowledge and behaviour in injured and noninjured cohorts. SETTING: Blackcomb Mountain, Whistler, British Columbia. PARTICIPANTS: A total of 863 noninjured and 118 injured skiers and snowboarders aged five to 17 years using Blackcomb during 1993/94. INTERVENTION: Skier Knowledge Inventory Questionnaire. RESULTS: The injured cohort had less knowledge of the Skiers Responsibility Code. In both groups, almost half had had no lessons, 31% had had bindings adjusted by nonprofessionals and chair lift safety bars were used one ride in four by children age 13 to 17 years. The injuried cohort wore helmets slightly less often. Both groups regularly skied through the trees (60% to 70%), and one-thirds had skied on closed runs. Excessive speed was identified as the major cause of injury. Skiers did not recognize jumping as contributing to injury. CONCLUSIONS: Lack of knowledge of safety rules was more prevalent among the injured cohort. Skiing without due care – including skiing through tress, skiing on closed runs, skiing with excessive speed and jumping, particularly by snowboarders – were identified as potential causes of injury. PMID:20401273

Sidecut radius and kinetic energy: equipment designed to reduce risk of severe traumatic knee injuries in alpine giant slalom ski racing

PubMed Central

Kröll, Josef; Spörri, Jörg; Gilgien, Matthias; Schwameder, Hermann; Müller, Erich

2016-01-01

Background Kinetic energy (Ekin) increases with speed by the power of 2 and is considered a major risk factor for injuries in alpine ski racing. There is no empirical knowledge about the effect of ski geometry on Ekin. Consequently, the aim of this study was to investigate the influence of sidecut radius on the progress of Ekin while skiing through a multigate section in giant slalom (GS). Methods 5 European-Cup level athletes skied on three different pairs of GS skis varying in sidecut radii (30, 35 and 40 m). Each athlete's position over time within a six gate section (including flat and steep terrain) was captured by the use of a differential Global Navigational Satellite System. Ekin, speed, time and path length were analysed for each pair of skis used. Results When using skis with greater sidecut radius, average Ekin was significantly lower over the entire six gate section, but not locally at every turn cycle. Particular decreases of Ekin were observed for both turns on the flat terrain, as well as for the turn at the terrain transition and the first turn on the steep terrain. The observed decreases in Ekin were found to be primarily explainable by increases in turn time. Conclusions With respect to typical sport mechanisms that cause severe knee injuries, using skis with greater sidecut radius potentially provides additional injury preventative gain, particularly in specific areas within a run. However, this injury preventative gain during falls in GS should not be overestimated. PMID:26702015

Effect of ski geometry on aggressive ski behaviour and visual aesthetics: equipment designed to reduce risk of severe traumatic knee injuries in alpine giant slalom ski racing

PubMed Central

Kröll, Josef; Spörri, Jörg; Gilgien, Matthias; Schwameder, Hermann; Müller, Erich

2016-01-01

Background/Aim Aggressive ski-snow interaction is characterised by direct force transmission and difficulty of getting the ski off its edge once the ski is carving. This behaviour has been suggested to be a main contributor to severe knee injuries in giant slalom (GS). The aim of the current study was to provide a foundation for new equipment specifications in GS by considering two perspectives: Reducing the ski's aggressiveness for injury prevention and maintaining the external attractiveness of a ski racer's technique for spectators. Methods Three GS ski prototypes were defined based on theoretical considerations and were compared to a reference ski (Pref). Compared to Pref, all prototypes were constructed with reduced profile width and increased ski length. The construction radius (sidecut radius) of Pref was ≥27 m and was increased for the prototypes: 30 m (P30), 35 m (P35), and 40 m (P40). Seven World Cup level athletes performed GS runs on each of the three prototypes and Pref. Kinetic variables related to the ski-snow interaction were assessed to quantify the ski's aggressiveness. Additionally, 13 athletes evaluated their subjective perception of aggressiveness. 15 sports students rated several videotaped runs to assess external attractiveness. Results Kinetic variables quantifying the ski's aggressiveness showed decreased values for P35 and P40 compared to Pref and P30. Greater sidecut radius reduced subjectively perceived aggressiveness. External attractiveness was reduced for P40 only. Conclusions This investigation revealed the following evaluation of the prototypes concerning injury prevention and external attractiveness: P30: no preventative gain, no loss in attractiveness; P35: substantial preventative gain, no significant loss in attractiveness; P40: highest preventative gain, significant loss in attractiveness. PMID:26603647

Injuries and illnesses in a cohort of elite youth alpine ski racers and the influence of biological maturity and relative age: a two-season prospective study

PubMed Central

Müller, Lisa; Hildebrandt, Carolin; Müller, Erich; Oberhoffer, Renate; Raschner, Christian

2017-01-01

Background Studies on injuries and illnesses involving youth ski racers younger than 15 years are lacking in the literature. The aim of this study was prospectively to assess the incidence, prevalence, and severity of traumatic and overuse injuries, as well as illnesses of elite youth ski racers with regard to sex, biological maturity status, and relative age. Subjects and methods A prospective, longitudinal cohort design was used to monitor the anthropometrics, training characteristics, traumatic and overuse injuries, and illnesses of 82 elite youth ski racers (51 males, 31 females, age 9–14 years) over 2 consecutive years. The exact training exposure (skiing and athletic) was recorded. Relative age and estimated biological maturity status were assessed. Results Relatively low injury incidence or prevalence (traumatic, 0.86/1,000 hours of training; overuse, 0.28/1,000 hours) and comparably high illness prevalence (2.4/athlete) were reported. The knee was the most commonly affected body part (traumatic injuries 36.5%, overuse injuries 82%). A high number of bone fractures were revealed (46%), while no stress fractures occurred; 66% of the illnesses were respiratory tract infections. No differences were found between males and females, the differing maturity groups, or relative age quartiles. Early-maturing athletes had comparably low traumatic and overuse-injury rates. Relatively younger athletes had low traumatic injury rates. Conclusion The injury-prevention measures implemented in the training process of youth ski racers seem to contribute to a low incidence of injury. Biological maturity status should be considered in the training process to prevent injuries in late-maturing athletes. PMID:28546774

Myths Concerning Alpine Skiing Injuries

PubMed Central

Johnson, Robert J.; Ettlinger, Carl F.; Shealy, Jasper E.

2009-01-01

There are many commonly discussed myths about ski safety that are propagated by industry, physicians, and skiers. Through a review of the literature concerning 12 such topics, this article demonstrates that the following are untrue: (1) Broken legs have been traded for blown-out knees. (2) If you know your DIN (a slang term for release indicator value), you can adjust your own bindings. (3) Toe and heel piece settings must be the same to function properly. (4) Formal ski instruction will make you safer. (5) Very short skis do not need release bindings. (6) Spending a lot of money on children’s equipment is not worth the cost. (7) Children need plenty of room in ski boots for their growing feet. (8) If you think you are going to fall, just relax. (9) Exercise can prevent skiing injuries. (10) Lower release settings can reduce the risk of anterior cruciate ligament injury. (11) Buying new ski equipment is safer than renting. (12) Skiing is among the most dangerous of activities. It is important for the skiing public, physicians, and all those interested in improving skiing safety to verify the measures they advocate. The statements analyzed here are simply untrue and have the potential to cause harm if taken as fact by those exposed to these unsupported opinions. PMID:23015911

Risk Factors for Anterior Cruciate Ligament Injury in Competitive Adolescent Alpine Skiers

PubMed Central

Westin, Maria; Harringe, Marita L.; Engström, Björn; Alricsson, Marie; Werner, Suzanne

2018-01-01

Background: There is a high risk for anterior cruciate ligament (ACL) injuries in alpine skiers. To reduce or try to prevent these injuries, intrinsic and extrinsic risk factors need to be identified. Purpose: To identify possible intrinsic and extrinsic ACL injury risk factors among competitive adolescent alpine skiers. Study Design: Case-control study; Level of evidence, 3. Methods: Between 2006 and 2009, a cohort of 339 alpine ski students (176 male, 163 female) from Swedish ski high schools were prospectively observed in terms of ACL injuries. First-time ACL injuries were recorded. In September, prior to each ski season, the skiers were clinically examined according to a specific knee protocol. Results: Overall, 11 male and 14 female skiers sustained a total of 25 first-episode ACL injuries. The majority of injuries occurred in the left knee (P < .05). Skiers who had participated in alpine skiing for >13 years (hazard ratio, 0.83; 95% CI, 0.68-1.00; P < .05) had a reduced risk of sustaining an ACL injury. Eighteen ACL injuries occurred during training, 12 in the technical discipline of giant slalom, and 8 in slalom. Fourteen skiers reported not to be fatigued at all at the time of injury, and 8 skiers reported that they were somewhat fatigued. Conclusion: ACL injuries occurred more often in the left knee than the right. This should be taken into consideration in the design of ACL injury prevention programs. Those who reported a higher number of active years in alpine skiing showed a reduced risk of sustaining an ACL injury. No other factor among those studied could be identified as an independent risk factor for ACL injury. PMID:29780835

Downhill ski injuries in children and adolescents.

PubMed

Meyers, Michael C; Laurent, C Matthew; Higgins, Robert W; Skelly, William A

2007-01-01

Downhill skiing is considered to be an enjoyable activity for children and adolescents, but it is not without its risks and injuries. Injury rates now range between 3.9 and 9.1 injuries per 1000 skier days, and there has been a well documented increase in the number of trauma cases and fatalities associated with this sport. Head and neck injuries are considered the primary cause of fatal injuries and constitute 11-20% of total injuries among children and adolescents. Cranial trauma is responsible for up to 54% of total hospital injuries and 67% of all fatalities, whereas thoracoabdominal and spine injuries comprise 4-10% of fatalities. Furthermore, there has been an increase in the proportion of upper extremity trauma with acromioclavicular dislocations, and clavicle and humeral fractures accounting for the majority (22-79%) of the injuries. However, the most common and potentially serious injuries in children and adolescents are those to the lower extremity, with knee sprains and anterior cruciate ligament tears accounting for up to 47.7% of total injuries. Knee sprains and grade III ligament trauma associated with lower leg fractures account for 39-77% of ski injuries in this young population. Approximately 15% of downhill skiing injuries among children and adolescents are caused by musculoskeletal immaturity. Other factors include excessive fatigue, age, level of experience, and inappropriate or improperly adjusted equipment. Collisions and falls constitute a significant portion (up to 76%) of trauma, and are commonly associated with excessive speed, adverse slope conditions, overconfidence leading to carelessness, and behavioural patterns within and among gender. The type and severity of injuries are typically functions of biomechanical efficiency, skiing velocity or slope conditions; however, a multiplicative array of intrinsic and extrinsic factors may simultaneously be involved. Despite extensive efforts to provide a comprehensive picture of the aetiology of injury, limitations have hampered reporting. These limitations include age and injury awareness, data collection challenges, lack of uniformity in the definition or delineation of age classification and lack of knowledge of predisposing factors prior to injury. Since skill level is the primary impetus in minimising ski injuries, formal instruction focusing on strategies such as collision avoidance and helmet use, fall training minimising lower extremity trauma, altering ski technique and avoiding behaviours that lead to excessive risk are, therefore, highly recommended. Skiing equipment should be outfitted to match the young skier's height, weight, level of experience, boot size and slope conditions. Additionally, particular attention should be paid to slope management (i.e. overcrowding, trail and obstacle marker upkeep) and minimising any opportunity for excessive speed where children are present. Whether increases in knowledge, education and technology will reduce predisposition to injury among this population remains to be seen. As with all high-risk sports, the answer may lie in increased wisdom and responsibility of both the skier and the parent to ensure an adequate level of ability, self-control and simply common sense as they venture out on the slopes.

The skiers knee without swelling or instability, a difficult diagnosis: a case report

PubMed Central

O'Donnell, Mark E; Badger, Stephen A; Campbell, David; Loan, Willie; Sinnott, Brendan

2007-01-01

Skiing as a recreational activity has increased exponentially in the last twenty-years. Similar to any sporting activity, participants can sustain various types of injury, which provides the emergency departments with a continuous supply of patients. The injury pattern from the slopes has also changed over this time period, due to alterations and improvements in ski equipment. An increased diversity in alpine skiing techniques, as well as snowboarding and cross-terrain disciplines has also influenced this change. We present a multi-media experience of a high-speed ski fall that caused a valgus-external rotation injury to the right knee that precluded the patient from further ski activity. There was no bruising, swelling or instability demonstrated and the patient returned to ski activities 24-hours post-injury. Although this injury appeared clinically benign initially, the patient complained of persistent pain around the right knee which was causing occupational difficulties. Following normal clinical assessment, the patient returned to work but continued to complain of persistent pain at the lateral aspect of the right knee. Magnetic Resonance Imaging (MRI) demonstrated extensive bone marrow oedema (BMO), a mild depression of the articular cortex compression with a small focus of articular cartilage disruption and microfractures of the lateral tibial plateau. The patient was treated conservatively and remains well with avoidance of impact exercises 14-months post-injury. In the presence of any high speed injury, we would stress that regardless of initial normal investigations, clinical suspicion should remain paramount and not deter the physician from further investigation in the presence of continuing symptomatology. PMID:17448236

Musculoskeletal Injury in Paddle Sport Athletes.

PubMed

Griffin, Andrew R; Perriman, Diana M; Neeman, Teresa M; Smith, Paul N

2018-05-16

Kayak racing has been an Olympic sport since 1936. The sport is evolving with the introduction of ocean skis and stand-up-paddle boards (SUP). Musculoskeletal injury incidence surveys have been conducted for ultra-marathon events, but no data have been published for other racing formats. To identify and compare the rates and types of injuries sustained by paddling athletes as a function of discipline and training parameters in Sprint, Marathon, Ultra-Marathon, and Ocean events. Competitors from 6 kayak and/or ocean surf-ski races in Australia were surveyed. Before each race, competitors were asked to complete a questionnaire. The questionnaire investigated paddling-related injuries over the previous 5 years, athlete morphology, flexibility, equipment and its setup, training volume, and environment. Five hundred eighty-three competitors were surveyed. Disciplines included 173 racing-kayak (K1), 202 touring-kayak, 146 ocean-skis, 42 SUP, and 20 other. The top 5 paddling-related injuries were shoulder (31%), low back (23.5%), wrist (16.5%), neck (13.7%), and elbow (11.0%). The highest percentage of injury was found in K1 paddlers for shoulder (40.5%), SUP for low back (33.3%), and ocean-ski for wrist (22.6%). After controlling for on-water training hours, the relative risk (RR) of wrist injury was significantly increased in ocean-ski paddlers (1.86) and in paddlers with decreased flexibility (1.53-1.83). Relative risk of shoulder and low-back injury was significantly increased in athletes with lower training volumes (1.82-2.07). Younger athletes had lower RR of wrist and shoulder injury (0.58-0.62).

[Snow trauma: comparison between skiers and snowboarders].

PubMed

Gigli Berzolari, Francesca; Marchetti, Pierpaolo; Mancini, Matteo

2009-01-01

skiing is practiced by million of persons every year, while snowboard is an emerging sport. This study compares the types of injury produced by the two sports. an observational study based on current data concerning traumas in skiing and snowboard. 1,264 skiers and 228 snowboarders injured were studied. Student's t test and chi-square test, logistic regression. snow injuries occurring in the ski resorts of agordino (Belluno), Arabba-Marmolada, Alleghe and Falcade between December 2006 and April 2007. Data were collected from the database of the Agordo Public Hospital, of the 118 Emergency service of Pieve di Cadore, and of several ski resorts. age, sex, country area, kind of injury, numbers, severity and type of trauma, injury time, prognosis, part of the body injured. the two sports differ with regard to trauma types: sprains and distortions are more frequent in skiers, whereas fractures (breaks) are more frequent in the snowboard. Lower limbs (knee) in ski and upper limbs (wrist) in snowboard are the main lesion sites. With regard to the ankle's injuries, no difference was found between the two sport: this contrasts with previous findings reported in the literature. Severity of trauma is not related to the kind of sport. the results of the present study agree with previous findings with regard to the type of lesions observed in the two sports. Among snowboarders, it is possible that recent materials and equipments reduce ankle injury risk. In spite of the differences in equipment and gestures, the consequences of injury are similar in the two sports.

INJURY PATTERNS IN ADOLESCENT ELITE ENDURANCE ATHLETES PARTICIPATING IN RUNNING, ORIENTEERING, AND CROSS-COUNTRY SKIING

PubMed Central

Floström, Frida; Frohm, Anna; Heijne, Annette

2017-01-01

Background Prospective injury registration studies, monitoring adolescent elite athletes, are sparse in running, orienteering and cross-country skiing, yet essential for developing prevention programs. Purpose The aims of this study were to describe the injury prevalence/incidence, severity grade, injury location, risk factors and the prevalence of illness in running (RU), orienteering (OR) and cross-country skiing athletes (CR). Study Design Prospective cohort study. Methods One hundred fifty adolescent elite athletes (age range 16-19), participating in orienteering (25 females, 20 males), running (13 females, 18 males), cross-country skiing (38 females, 36 males), from 12 National Sports High Schools in Sweden, were prospectively followed over one calendar year using a reliable and validated web-based questionnaire. Results The main finding was that the average weekly injury prevalence was higher during the pre-season compared to the competitive season in all three sports. RU reported the significantly (p<0.05) highest average weekly injury prevalence (32.4%) and substantial injury prevalence (17.0%), compared to OR (26.0, 8.2%) and CR (21.1%, 8.9%). Most injuries occurred in the lower extremity (RU 94.4%; OR 91.9%; CR 49.9%) and foot and knee injuries had the highest severity grade in all three sports. History of serious injury (p=0.002, OR 4.0, 95% CI 1.6-9.7) and current injury at study start (p=0.004, OR 4.0, 95% CI 1.5-11.2) were identified as the strongest risk factors for substantial injury. Younger athletes aged 16 (p=0.019, OR 2.6, 95% CI 1.2-5.8) and 17 (p=0.045, OR 2.4, 95% CI 1.0-5.9), had a significantly higher injury risk for substantial injury compared to older athletes aged 18-19. Conclusion Practitioners should be aware of the increased injury risk during pre-season and in younger athletes. By focus on prevention of foot and knee injuries, the injuries with the highest severity grade will be targeted in adolescent elite athletes participating in running, orienteering and cross-country skiing. Level of evidence 2b PMID:29181259

INJURY PATTERNS IN ADOLESCENT ELITE ENDURANCE ATHLETES PARTICIPATING IN RUNNING, ORIENTEERING, AND CROSS-COUNTRY SKIING.

PubMed

von Rosen, Philip; Floström, Frida; Frohm, Anna; Heijne, Annette

2017-10-01

Prospective injury registration studies, monitoring adolescent elite athletes, are sparse in running, orienteering and cross-country skiing, yet essential for developing prevention programs. The aims of this study were to describe the injury prevalence/incidence, severity grade, injury location, risk factors and the prevalence of illness in running (RU), orienteering (OR) and cross-country skiing athletes (CR). Prospective cohort study. One hundred fifty adolescent elite athletes (age range 16-19), participating in orienteering (25 females, 20 males), running (13 females, 18 males), cross-country skiing (38 females, 36 males), from 12 National Sports High Schools in Sweden, were prospectively followed over one calendar year using a reliable and validated web-based questionnaire. The main finding was that the average weekly injury prevalence was higher during the pre-season compared to the competitive season in all three sports. RU reported the significantly (p<0.05) highest average weekly injury prevalence (32.4%) and substantial injury prevalence (17.0%), compared to OR (26.0, 8.2%) and CR (21.1%, 8.9%). Most injuries occurred in the lower extremity (RU 94.4%; OR 91.9%; CR 49.9%) and foot and knee injuries had the highest severity grade in all three sports. History of serious injury (p=0.002, OR 4.0, 95% CI 1.6-9.7) and current injury at study start (p=0.004, OR 4.0, 95% CI 1.5-11.2) were identified as the strongest risk factors for substantial injury. Younger athletes aged 16 (p=0.019, OR 2.6, 95% CI 1.2-5.8) and 17 (p=0.045, OR 2.4, 95% CI 1.0-5.9), had a significantly higher injury risk for substantial injury compared to older athletes aged 18-19. Practitioners should be aware of the increased injury risk during pre-season and in younger athletes. By focus on prevention of foot and knee injuries, the injuries with the highest severity grade will be targeted in adolescent elite athletes participating in running, orienteering and cross-country skiing. 2b.

Effect of ski geometry and standing height on kinetic energy: equipment designed to reduce risk of severe traumatic injuries in alpine downhill ski racing.

PubMed

Gilgien, Matthias; Spörri, Jörg; Kröll, Josef; Müller, Erich

2016-01-01

Injuries in downhill (DH) are often related to high speed and, therefore, to high energy and forces which are involved in injury situations. Yet to date, no study has investigated the effect of ski geometry and standing height on kinetic energy (EKIN) in DH. This knowledge would be essential to define appropriate equipment rules that have the potential to protect the athletes' health. During a field experiment on an official World Cup DH course, 2 recently retired world class skiers skied on 5 different pairs of skis varying in width, length and standing height. Course characteristics, terrain and the skiers' centre of mass position were captured by a differential Global Navigational Satellite System-based methodology. EKIN, speed, ski-snow friction force (FF), ground reaction force (FGRF) and ski-snow friction coefficient (CoeffF) were calculated and analysed in dependency of the used skis. In the steep terrain, longer skis with reduced width and standing height significantly decreased average EKIN by ∼ 3%. Locally, even larger reductions of EKIN were observed (up to 7%). These local decreases in EKIN were mainly explainable by higher FF. Moreover, CoeffF differences seem of greater importance for explaining local FF differences than the differences in FGRF. Knowing that increased speed and EKIN likely lead to increased forces in fall/crash situations, the observed equipment-induced reduction in EKIN can be considered a reasonable measure to improve athlete safety, even though the achieved preventative gains are rather small and limited to steep terrain. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Sidecut radius and the mechanics of turning—equipment designed to reduce risk of severe traumatic knee injuries in alpine giant slalom ski racing

PubMed Central

Spörri, Jörg; Kröll, Josef; Gilgien, Matthias; Müller, Erich

2016-01-01

Background There is limited empirical knowledge about the effect of ski geometry, particularly in the context of injury prevention in alpine ski racing. We investigated the effect of sidecut radius on biomechanical variables related to the mechanics of turning. Methods During a field experiment, six European Cup level athletes skied on three different pairs of giant slalom (GS) skis varying in sidecut radii (30 m, 35 m and 40 m). Using a video-based three-dimensional (3D) kinematic system, a 22-point body segment model of the athletes was reconstructed in 3D, and the variables ground reaction force, centre of mass (COM) speed, COM turn radius, ski turn radius, edge angle, fore/aft position and skid angle were calculated. Results While steering out of the fall line after gate passage, ground reaction force significantly differed between the 30 m and 40 m skis and between the 35 m and 40 m skis. These differences were mainly explainable by larger COM turn radii when skiing on the 40 m ski. During the same turn phase, significant differences in ski turn radius also were found, but there were no differences in edge angle, fore/aft position and skid angle. Summary The sidecut-induced reduction in ground reaction force and the sidecut-induced increase in centre of mass and ski turn radius observed in this study provides indirect evidence of reduced self-steering of the ski. Self-steering plays a central role in the mechanism of anterior cruciate ligament rupture in alpine ski racing. PMID:26702014

[Head injuries in childhood caused by skiing and their optimal prevention].

PubMed

Oh, S; Schmid, U D

1983-04-01

During the last three skiing seasons we have treated a total of 105 children in our clinical wards for skull-brain injuries caused by skiing accidents. 25 of these cases (25.2%) were operated on, mostly because of a depressed fracture (92%) with or without brain lesion/bleeding, which the children incurred by colliding with various obstacles. Uncontrolled excessive speed and careless skiing methods are the main reasons for these injuries. However, the responsibility for the increasing number of skisport-connected skull-brain injuries does not lie with the children alone, but more so with us grown-ups, i.e. the parents, teachers and physicians, as long as we do not preach and emphatically insist on the implementation of indirect and direct specific measures of accident prevention. Based on an analysis of typical injuries and their many causes we come to the conclusion that, aside from the usual precautions, only one simple, sensible and effective prevention of skull-brain injuries is feasible, namely the "protection helmet". Similar to the existing crash-helmet law for motorcylists and just like for the professional skiracers, whom the children try to imitate more and more with regard to style and speed, we earnestly urge legislation to make the wearing of a protective helmet compulsory for all skiers up to 17 years of age.

[Epidemiology of winter sport injuries].

PubMed

Heim, D; Weymann, A; Loeliger, U; Matter, P

1993-01-01

The region Davos/Klosters is a big wintersport area in Switzerland, where more than 5 million kilometers of vertical drop are skied per year. Over the last 20 years 28,777 patients with wintersport accidents have been treated in the 100-bed hospital of Davos, 85% of these patients have sustained their accident while skiing. An analysis of these datas show an increase of ski accidents as well as an increase of the distance skied. Especially an increase in snowboard accidents is noted over the last few years with a preponderance of lesions of the upper extremity. Injuries of the head, the trunk and simple skin lacerations remain stable over that period. Injuries of the upper extremity are increasing, whereas lower extremity lesions are slightly decreasing. There is a significant decrease of fractures of the leg, while at the same time an important increase of knee injuries is noted. Young patients below 20 years and those between 31 and 40 years of age sustained less accidents over the last 20 years, while the rest of the alpine skiers remain more or less stable in their accident incidence.

Space-Spurred Metallized Materials

NASA Technical Reports Server (NTRS)

1988-01-01

Among a score of applications for a space spinoff reflective material called TXG is the emergency blanket manufactured by Metallized Products, Inc. Used by ski patrol to protect a skier shaken by a fall, the blanket retains up to 80% of user's body heat preventing post accident shock or chills. Carried by many types of emergency teams, blanket is large when unfolded, but folds into a package no larger than a deck of cards. Many other uses include, emergency blankets, all weather blanket, tanning blanket, window shields, radar reflector life raft canopies, etc.

The increasing incidence of snowboard-related trauma

PubMed Central

Hayes, John R.; Groner, Jonathan I.

2013-01-01

Purpose To investigate injuries among children and adolescents who participate in downhill sports. Methods We collected trauma registry data (January 1999–May 2006) from a level 1 pediatric trauma center with an average snowfall of 28 in (71 cm)/y. Cases were analyzed for injury mechanism, injury type, organ injured, Injury Severity Score, age, sex, and whether or not an operation was required. Results There were 57 snowboarders and 22 skiers admitted during the study period. Forty-one (72%) of snowboarders and 16 (73%) of skiers required operations; 32 (56%) of snowboarders and 9 (41%) of skiers sustained fractures; and 14 (25%) of snowboarders and 6 (27%) of skiers sustained abdominal injuries. (P = NS for all comparisons). Serious splenic injuries were more common in snowboarders (14% vs 4%), but the difference was not statistically significant. All skiing injuries occurred at recreational facilities (commercial skiing areas), whereas 12% of snowboard injuries occurred at home, other residence, or public parks (P = .08). The most striking finding is the rising number of snowboarding injuries and the relatively stable rate of skiing injuries (see graph). Conclusions As the popularity of snowboarding rises, snowboarding injuries in children are increasing. Pediatric surgeons should be wary of the “snowboard spleen.” PMID:18485968

The injury experience at the 2010 winter paralympic games.

PubMed

Webborn, Nick; Willick, Stuart; Emery, Carolyn A

2012-01-01

The objective of this study was to examine incidence proportion and the characteristics of athlete injuries sustained during the 2010 Vancouver Paralympic Games. Descriptive epidemiological study. All medical venues at the 2010 Vancouver Paralympic Games, Canada. A total of 505 athletes from 44 National Paralympic Committees participating in the 2010 Vancouver Winter Paralympic Games. Baseline covariates included sport specificity (ie, ice sledge hockey, alpine skiing, Nordic skiing, wheelchair curling), gender, age, and disability classification. All injuries that occurred during the 2010 Vancouver Paralympic Games. "Injury" was defined as any sport-related musculoskeletal complaint that caused the athlete to seek medical attention during the study period, regardless of the athlete's ability to continue with training or competition. The Injury Surveillance System identified a total of 120 injuries among 505 athletes [incidence proportion = 23.8% (95% confidence interval, 20.11-27.7)] participating in the 2010 Winter Paralympic Games. There was a similar injury incidence proportion among male (22.8%) and female (26.6%) athletes [incidence rate ratio = 1.1 (95% confidence interval, 0.7-1.7)]. Medical encounters for musculoskeletal complaints were generated in 34% of all sledge hockey athletes, 22% of alpine ski racers, 19% of Nordic skiers, and 18% of wheelchair curling athletes. The Injury Surveillance System identified sport injuries in 24% of all athletes participating in the 2010 Winter Paralympic Games. The injury risk was significantly higher than during the 2002 (9.4%) and 2006 (8.4%) Winter Paralympic Games. This may reflect improved data collection systems but also highlights the high risk of acute injury in alpine skiing and ice sledge hockey at Paralympic Games. These data will assist future Organizing Committees with the delivery of medical care to athletes with a disability and guide future injury prevention research.

High Injury Burden in Elite Adolescent Athletes: A 52-Week Prospective Study.

PubMed

von Rosen, Philip; Heijne, Annette; Frohm, Anna; Fridén, Cecilia; Kottorp, Anders

2018-03-01

  Our understanding of the injury burden in elite adolescent athletes in most sports is limited or unknown because of the lack of prospective, long-term injury studies.   To describe injury patterns in terms of type, location, prevalence and incidence, recurrence, and severity grade; time to first injury; and prevalence of illness in elite adolescent athletes and to compare differences in injury data by sex and sport type.   Cohort study.   Fifteen national sports high schools in Sweden.   Participants were 284 elite adolescent athletes (boys = 147, girls = 137; median age = 17 years; 25th-75th percentile range = 16-18 years) competing at a high national level for their age in athletics (track and field), cross-country skiing, downhill skiing, freestyle skiing, handball, orienteering, or ski orienteering.   All athletes were monitored weekly over 52 weeks, using a validated online questionnaire to identify injury type, location, prevalence or incidence, and severity grade; time to first injury; and prevalence of illness.   Among all athletes, 57.4% reported at least 1 new injury, whereas the 1-year injury prevalence was 91.6%. The overall injury incidence was 4.1/1000 hours of exposure to sport, and every week, on average, 3 of 10 (30.8%) elite adolescent athletes reported being injured. Of all injuries from which athletes recovered, 22.2% (n = 35) resulted in absence from normal training for at least 2 months. Female athletes reported higher ( P < .05) average weekly injury prevalence and substantial injury prevalence (injuries leading to a moderate or severe reduction in sport performance or participation or time loss) than male athletes.   A considerable number of elite adolescent athletes were injured weekly, resulting in serious consequences for sport participation, training, or performance (or a combination of these). Appropriately designed interventions to prevent knee and foot injuries will target both the greatest number of injuries and the injuries with the most serious consequences in elite adolescent athletes.

Effect of ski geometry and standing height on kinetic energy: equipment designed to reduce risk of severe traumatic injuries in alpine downhill ski racing

PubMed Central

Gilgien, Matthias; Spörri, Jörg; Kröll, Josef; Müller, Erich

2016-01-01

Background Injuries in downhill (DH) are often related to high speed and, therefore, to high energy and forces which are involved in injury situations. Yet to date, no study has investigated the effect of ski geometry and standing height on kinetic energy (EKIN) in DH. This knowledge would be essential to define appropriate equipment rules that have the potential to protect the athletes’ health. Methods During a field experiment on an official World Cup DH course, 2 recently retired world class skiers skied on 5 different pairs of skis varying in width, length and standing height. Course characteristics, terrain and the skiers’ centre of mass position were captured by a differential Global Navigational Satellite System-based methodology. EKIN, speed, ski–snow friction force (FF), ground reaction force (FGRF) and ski–snow friction coefficient (CoeffF) were calculated and analysed in dependency of the used skis. Results In the steep terrain, longer skis with reduced width and standing height significantly decreased average EKIN by ∼3%. Locally, even larger reductions of EKIN were observed (up to 7%). These local decreases in EKIN were mainly explainable by higher FF. Moreover, CoeffF differences seem of greater importance for explaining local FF differences than the differences in FGRF. Conclusions Knowing that increased speed and EKIN likely lead to increased forces in fall/crash situations, the observed equipment-induced reduction in EKIN can be considered a reasonable measure to improve athlete safety, even though the achieved preventative gains are rather small and limited to steep terrain. PMID:26702013

Sports injuries and illnesses in the Lillehammer 2016 Youth Olympic Winter Games.

PubMed

Steffen, Kathrin; Moseid, Christine Holm; Engebretsen, Lars; Søberg, Pia K; Amundsen, Olav; Holm, Kristian; Moger, Thomas; Soligard, Torbjørn

2017-01-01

Injury and illness surveillance during high-level youth sports events is an important first step in health prevention and caretaking of the young elite athletes. To analyse injuries and illnesses that occurred during the 10 days 2nd Youth Olympic Winter Games (YOG), held in Lillehammer 2016. We recorded the daily occurrence (or non-occurrence) of injuries and illnesses through the reporting of (1) all National Olympic Committee (NOC) medical teams and (2) the polyclinic and medical venues by the Lillehammer Organising Committee (LYOCOG) medical staff. In total, 1083 athletes (48 double-starters), 46% (n=502) of them females, from 70 NOCs were registered in the study. NOCs and LYOCOG reported 108 injuries and 81 illnesses, equalling to 9.5 injuries and 7.2 illnesses per 100 athletes. The percentage of injured athletes was highest in the snowboard and ski slopestyle and cross disciplines, alpine skiing and skeleton, and lowest in the Nordic skiing disciplines. Approximately, two-thirds of the injuries (n=71, 65.7%) prevented the athlete from training or competition, while 10 injuries (9.3%) were registered with an estimated absence from sport for >7 days. The rate of illness was highest in curling and the Nordic skiing disciplines with most of them being respiratory tract infections (81.5%). Overall, 9% of the athletes incurred at least one injury during the games, and 7% an illness, which is similar to the first YOG in Innsbruck 2012 and slightly lower compared with previous Winter Olympic Games. The incidence of injuries and illnesses varied substantially between sports. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

[Comparison between ski and snowboarding accidents. Current overview from the ski area Arosa (Switzerland) (1988/89 to 1994/95)].

PubMed

Fischler, L; Röthlisberger, M

1996-06-11

The ski resort of Arosa (Switzerland) is geographically isolated and has recorded it winter sports accidents since 1969. Based on this reliable data, the ski (3877 in total) and snowboard (512 in total) accidents of the last seven years were statistically analyzed. The study showed that snowboarding isn't much more dangerous than skiing the number of accidents was about the same in both groups, whereas snowboarders were less likely to be admitted to a hospital or to get injured by collision. The average age of snowboarders was 21.6 years, almost 20 years lower than that of the skiers. Both sexes were about equally represented. Most snowboarders had injuries of the upper extremity (14% fractures of the radius, 9% distortions), particularly because of falling backward after losing balance. In both groups (skiers and snowboarders) 60% of all injuries were of low grade, which did not lead to long absence from work. The results are discussed and compared with already existing publications.

Three-Dimensional Lower Extremity Joint Loading in a Carved Ski and Snowboard Turn: A Pilot Study

PubMed Central

Müller, Erich

2014-01-01

A large number of injuries to the lower extremity occur in skiing and snowboarding. Due to the difficulty of collecting 3D kinematic and kinetic data with high accuracy, a possible relationship between injury statistic and joint loading has not been studied. Therefore, the purpose of the current study was to compare ankle and knee joint loading at the steering leg between carved ski and snowboard turns. Kinetic data were collected using mobile force plates mounted under the toe and heel part of the binding on skies or snowboard (KISTLER). Kinematic data were collected with five synchronized, panning, tilting, and zooming cameras. An extended version of the Yeadon model was applied to calculate inertial properties of the segments. Ankle and knee joint forces and moments were calculated using inverse dynamic analysis. Results showed higher forces along the longitudinal axis in skiing and similar forces for skiing and snowboarding in anterior-posterior and mediolateral direction. Joint moments were consistently greater during a snowboard turn, but more fluctuations were observed in skiing. Hence, when comparing joint loading between carved ski and snowboard turns, one should differentiate between forces and moments, including the direction of forces and moments and the turn phase. PMID:25317202

What are the exercise-based injury prevention recommendations for recreational alpine skiing and snowboarding? A systematic review.

PubMed

Hébert-Losier, Kim; Holmberg, Hans-Christer

2013-05-01

Skiing and snowboarding are two activities that significantly contribute to the total number of sports-related injuries reported per year. Strength, endurance and cardiovascular fitness are central components in sports injury prevention. Providing exercises and training recommendations specific to recreational skiers and snowboarders is important in both injury prevention and reducing the prevalence and cost associated with alpine winter sports injuries. The aim of this paper was to systematically review the literature for injury prevention recommendations specific to recreational alpine skiers and snowboarders. The focus was to discern recommendations that targeted physical fitness, exercise and/or training in the prevention of musculoskeletal injuries in these two sports. Fourteen electronic databases were searched in October 2011 using relevant MeSH terms and key words. Articles were included if they addressed injury prevention, recreational alpine skiing or snowboarding and musculoskeletal injuries. Only original research articles published in peer-reviewed journals, and in the English-language, were reviewed. Articles on elite athletes were excluded. Two independent reviewers quality assessed articles meeting inclusion criteria using a modified version of the Downs and Black Quality Assessment Checklist. Data on study population, study design, study location and injury prevention recommendation(s) were extracted from articles using a standard form and subsequently categorized to facilitate data synthesis. A total of 30 articles met the inclusion criteria and were reviewed, having an average ± standard deviation quality score of 72% ± 17% (range: 23-100 %). Overall, 80 recommendations for the prevention of musculoskeletal injuries in recreational alpine skiers and snowboarders were identified and classified into five main groups: equipment (n = 24), education and knowledge (n = 11), awareness and behaviour (n = 15), experience (n = 10) and third-party involvement (n = 20). No recommendations pertained to physical fitness, exercise and/or training per se, or its role in preventing injury. A comprehensive meta-analysis was not possible because several articles did not report data in sufficient detail. The importance of targeting physical fitness in injury prevention is accepted in sports medicine and rehabilitation; yet, there was a paucity of articles included in this review that explicitly investigated this aspect with regards to recreational alpine skiing and snowboarding. The most frequent recommendations for preventing skiing and snowboarding injuries concerned equipment or the involvement of third parties. The dominance of equipment-related measures in the injury prevention literature may be rationalized from a sports biomechanics viewpoint, as these activities involve high velocities and impact forces. Nonetheless, this also indicates a need for appropriate levels of strength, endurance and conditioning to meet the technical demands of these sports. Bearing this in mind, future research is encouraged to investigate the role of physical fitness, exercise and training in decreasing the incidence and severity of skiing and snowboarding injuries in recreational athletes.

Supervision of School and Youth Groups on Lift-Served Ski Slopes: A Research Perspective

ERIC Educational Resources Information Center

Brookes, Andrew; Holmes, Peter

2014-01-01

Supervised practice is a common feature of many snow sports excursions to downhill ski resorts by school or youth groups, often in combination with lessons from a ski school. What is the role of supervision in preventing mishaps, injury, or fatalities? This article presents results of a search of published snow sports safety research for evidence…

The Risks and Benefits of Snow Sports for People with Disabilities: A Review of the Literature

ERIC Educational Resources Information Center

Nasuti, Gabriella; Temple, Viviene A.

2010-01-01

Snow sports are popular pastimes with therapeutic potential. The aim of this review is to evaluate the risk of injury and evidence of benefits of alpine skiing (including sit-skiing), Nordic skiing, and snowboarding for people with disabilities. Ten studies met the inclusion criteria from 357 citations. Research in this area is still in its…

The Waist Width of Skis Influences the Kinematics of the Knee Joint in Alpine Skiing

PubMed Central

Zorko, Martin; Nemec, Bojan; Babič, Jan; Lešnik, Blaz; Supej, Matej

2015-01-01

Recently alpine skis with a wider waist width, which medially shifts the contact between the ski edge and the snow while turning, have appeared on the market. The aim of this study was to determine the knee joint kinematics during turning while using skis of different waist widths (65mm, 88mm, 110mm). Six highly skilled skiers performed ten turns on a predefined course (similar to a giant slalom course). The relation of femur and tibia in the sagital, frontal and coronal planes was captured by using an inertial motion capture suit, and Global Navigation Satellite System was used to determine the skiers’ trajectories. With respect of the outer ski the knee joint flexion, internal rotation and abduction significantly decreased with the increase of the ski waist width for the greatest part of the ski turn. The greatest abduction with the narrow ski and the greatest external rotation (lowest internal rotation) with the wide ski are probably the reflection of two different strategies of coping the biomechanical requirements in the ski turn. These changes in knee kinematics were most probably due to an active adaptation of the skier to the changed biomechanical conditions using wider skis. The results indicated that using skis with large waist widths on hard, frozen surfaces could bring the knee joint unfavorably closer to the end of the range of motion in transversal and frontal planes as well as potentially increasing the risk of degenerative knee injuries. Key points The change in the skis’ waist width caused a change in the knee joint movement strategies, which had a tendency to adapt the skier to different biomechanical conditions. The use of wider skis or, in particular, skis with a large waist width, on a hard or frozen surface, could unfavourably bring the knee joint closer to the end of range of motion in transversal and frontal planes as well as may potentially increase the risk of degenerative knee injuries. The overall results of the abduction and internal rotation in respect to turn radii and ground reaction forces indicated that the knee joint movements are likely one of the key points in alpine skiing techniques. However, the skiing equipment used can still significantly influence the movement strategy. PMID:26336348

Cross-Country Skiing Injuries and Training Methods.

PubMed

Nagle, Kyle B

2015-01-01

Cross-country skiing is a low injury-risk sport that has many health benefits and few long-term health risks. Some concern exists that cross-country skiing may be associated with a higher incidence of atrial fibrillation; however, mortality rates among skiers are lower than those among the general population. While continuing to emphasize aerobic and anaerobic training, training methods also should promote ski-specific strength training to increase maximum force and its rate of delivery and to build muscular endurance to maintain that power through a race. Multiple tests are available to monitor training progress. Which tests are most appropriate depends on the specific events targeted. In addition to laboratory-based tests, there also are many simpler, more cost-effective tests, such as short time trials, that can be used to monitor training progress and predict performance particularly at the junior skier level where access and cost may be more prohibitive.

An Analysis of US Emergency Department Visits From Falls From Skiing, Snowboarding, Skateboarding, Roller-Skating, and Using Nonmotorized Scooters.

PubMed

Nathanson, Brian H; Ribeiro, Kara; Henneman, Philip L

2016-07-01

We analyzed the US incidence of emergency department (ED) visits and hospitalizations for falls from skiing, snowboarding, skateboarding, roller-skating, and nonmotorized scooters in 2011. The outcome was hospital admission from the ED. The primary analysis compared pediatric patients aged 1 to 17 years to adults aged 18 to 44 years. The analysis used ICD-9 E-codes E885.0 to E885.4 using discharge data from the Nationwide Emergency Department Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality. Approximately 214 000 ED visits met study criteria. Skiing injuries had the highest percentage of hospitalizations (3.30% in pediatric patients and 6.65% in adults 18-44 years old). Skateboard and snowboard injuries were more likely to require hospitalization than roller skating injuries in pediatric patients (odds ratio = 2.42; 95% CI = 2.14-2.75 and odds ratio = 1.83; 95% CI =1.55-2.15, respectively). In contrast, skateboard and snowboard injuries were less severe than roller-skating injuries in adults. © The Author(s) 2015.

Fundamental considerations in ski binding analysis.

PubMed

Mote, C D; Hull, M L

1976-01-01

1. The static adjustment of a ski binding by hand or by available machines is only an adjustment and is neither a static nor a dynamic evaluation of the binding design. Bindings of different design with identical static adjustments will perform differently in environments in which the forces are static or dynamic. 2. The concept of binding release force is a useful measure of binding adjustment, but it is inappropriate as a criterion for binding evaluation. First, it does not direct attention toward the injury causing mechanism, strain, or displacement in the leg. Second, it is only part of the evaluation in dynamic problems. 3. The binding release decision in present bindings is displacement controlled. The relative displacement of the boot and ski is the system variable. For any specified relative displacement the binding force can be any of an infinite number of possibilities determined by the loading path. 4. The response of the leg-ski system to external impulses applied to the ski is independent of the boot-ski relative motion as long as the boot recenters quickly in the binding. Response is dependent upon the external impulse plus system inertia, damping and stiffness. 5. When tested under half sinusoidal forces applied to a test ski, all bindings will demonstrate static and impulse loading regions. In the static region the force drives the binding to a relative release displacement. In the impulse region the initial velocity of the ski drives the binding to a release displacement. 6. The transition between the static and impulse loading regions is determined by the binding's capacity to store and dissipate energy along the principal loading path. Increased energy capacity necessitates larger external impulses to produce release. 7. In all bindings examined to date, the transmitted leg displacement or strain at release under static loading exceeds leg strain under dynamic or impact loading. Because static loading is responsible for many injuries, a skier should be able to release his bindings in every mode by simply pulling or twisting his foot outward. If that cannot be done without injury, the skier has identified for himself one type of fall that will result in injury. 8. And lastly, a little advice from Ben Franklin--"Carelessness does more harm than a want of knowledge."

[Skiing and snowboarding trauma in children: epidemiology, physiopathology, prevention and main injuries].

PubMed

Dohin, B; Kohler, R

2008-11-01

Skiing and snowboarding are leading to a risk of injuries in children. Beginners and experienced have higher risk of injuries, however, the first have less severe injuries than the latest. Risk factors of injury are: ability and experience, binding adjustment, slope characteristics, speed, collisions with objects or jumping and risky behavior of the young skiers and snowboarders. Lower limb injuries are most common in skier, especially knee sprains, conversely snowboarders present more upper limb injuries, especially wrist fractures. The frequency of head injuries does not decrease while helmet use increases but severity decreases. Despite prevention and wearing protections, the frequency of trauma does not decrease significantly, which could be in relation with higher speed and increased risky behavior. Main prevention factors are safety knowledge and safety behavior, correct binding adjustment, and use of protections.

[How frequent and why are skiers and snowboarders falling?].

PubMed

Philippe, M; Ruedl, G; Feltus, G; Woldrich, T; Burtscher, M

2014-12-01

Injuries in alpine skiing and snowboarding are mainly caused by falls. In 2002, a study was conducted to gain insight into the risk factors for falls when skiing or snowboarding. Since then, the evolution of skiing, snowboarding and safety equipment, as well as slope preparation, may have altered the frequency of falls while skiing or snowboarding. In total, 1436 male and female skiers and snowboarders from all age groups were interviewed from February until April 2012, in 6 Tyrolean ski resorts. The questionnaire was nearly identical to that used in 2002. It contained questions concerning personal characteristics, falls, equipment and risk taking behaviour. The incidence of falls among skiers was 0.076 ± 0.21 per hour and that among snowboarders was 0.429 ± 0.70 per hour. Age (OR: 0.96; CI: 0.95 - 0.97), soft snow conditions (OR: 4.1; CI: 1.9 - 8.8) and poor skiing skills (beginners and intermediates) (OR: 2.6; CI: 1.2 - 8.1) were predictive for falls during skiing. Poor snowboarding skills (beginners and intermediates) (OR: 8.3; CI: 3.1 - 27.4), wearing a helmet (OR: 2.3; CI: 1.2 - 4.6) and alcohol consumption (OR: 2.1; CI: 1.2 - 3.9) were predictive for falls during snowboarding. The incidence of falls among skiers and snowboarders was substantially lower when compared to that in 2002. Improvements in skiing and snowboarding equipment as well as slope preparation may have contributed to this favourable development. We strongly assume that the lowering in fall incidence may positively affect the injury incidence. © Georg Thieme Verlag KG Stuttgart · New York.

Explosive-residue compounds resulting from snow avalanche control in the Wasatch Mountains of Utah

USGS Publications Warehouse

Naftz, David L.; Kanagy, Leslie K.; Susong, David D.; Wydoski, Duane S.; Kanagy, Christopher J.

2003-01-01

A snow avalanche is a powerful force of nature that can play a significant role in developing mountain landscapes (Perla and Martinelli, 1975). More importantly, loss of life can occur when people are caught in the path of snow avalanches (Grossman, 1999). Increasing winter recreation, including skiing, snowboarding, snowmobiling, snowshoeing, and climbing in mountainous areas, has increased the likelihood of people encountering snow avalanches (fig. 1). Explosives are used by most ski areas and State highway departments throughout the Western United States to control the release of snow avalanches, thus minimizing the loss of human life during winter recreation and highway travel (fig. 2).Common explosives used for snow avalanche control include trinitrotoluene (TNT), pentaerythritoltetranitrate (PETN), cyclotrimethylenetrinitramine (RDX), tetrytol, ammonium nitrate, and nitroglycerin (Perla and Martinelli, 1975). During and after snowfall or wind loading of potential avalanche slopes, ski patrollers and Utah Department of Transportation personnel deliver explosive charges onto predetermined targets to artificially release snow avalanches, thereby rendering the slope safer for winter activities. Explosives can be thrown by hand onto target zones or shot from cannons for more remote delivery of explosive charges. Hand-delivered charges typically contain about 2 pounds of TNT or its equivalent (Perla and Martinelli, 1975).Depending on the size of the ski area, acreage of potential avalanche terrain, and weather conditions, the annual quantity of explosives used during a season of snow avalanche control can be substantial. For example, the three ski areas of Alta, Snowbird, and Brighton, plus the Utah Department of Transportation, may use as many as 11,200 hand charges per year (Wasatch Powderbird Guides, unpub. data, 1999) for snow avalanche control in Big and Little Cottonwood Canyons (fig. 3). If each charge is assumed to weigh 2 pounds, this equates to about 22,400 pounds of explosive hand charges per year. In addition, 2,240 to 3,160 Avalauncher rounds and 626 to 958 military artillery rounds (explosive mass not specified) are used each year by the three ski areas and the Utah Department of Transportation for snow avalanche control in Big and Little Cottonwood Canyons (Wasatch Powderbird Guides, unpub. data, 1999). The other ski area in Big Cottonwood Canyon, Brighton, uses about 2,000 pounds of explosives per year for snow avalanche control (Michele Weidner, Cirrus Ecological Solutions consultant, written commun., 2001).

Injury case-control studies using "other injuries" as controls.

PubMed

Marshall, Stephen W

2008-03-01

Studies of event-related (or "event-phase") interventions (such as ski helmets) can address injury at a specific body site (such as the head) by using as controls a group of people who experienced the same event (fall) and suffered injuries at other body sites (other than the head). The research question addressed by this type of study is the effect of an exposure or intervention (helmet) during the event phase (fall) of the causal chain. However, this is a valid case-control design only if the controls (skiers with other injuries) provide a reasonable proxy for the prevalence of exposure (helmet-wearing) in the underlying event-phase source population (skiers who fell). This assumption needs to be carefully assessed. Factors associated with both helmet-wearing and injury given a fall (eg, previous injury history, skiing inexperience, or risk-taking behavior) have considerable potential to create bias.

Sports injuries and illnesses during the Granada Winter Universiade 2015

PubMed Central

Gallo-Vallejo, Miguel Ángel; de la Cruz-Márquez, Juan Carlos; de la Cruz-Campos, Adrián; de la Cruz-Campos, Juan Carlos; Pestaña-Melero, Francisco Luis; Carmona-Ruiz, Ginés; Gallo-Galán, Luz María

2016-01-01

Objective To analyse the incidence of diseases and injuries suffered by athletes participating in the 27th Winter Sports Universiade held in Granada, Spain. Methods The daily occurrence of injuries and diseases was registered at the point of first aid (Borreguiles, 2665 metres above sea level (masl)) and in the clinic of Pradollano (2017 masl), both in Sierra Nevada, as well as in medical services provided by the organising committee of Granada 2015 Universiade and located in sport pavilions in which indoor competitions are held. Results A total of 1109 athletes (650 men, 58.61%; 459 women, 41.39%). Nine diseases and 68 injuries were recorded. In total, the rate of injury was 6.13% (7.07% for men and 4.79% for women). The percentage of injury was highest in alpine skiing (10.34%) followed by freestyle skiing (8.62%). In relation to the time of exposure, freestyle skiing showed the shortest time of exposure (0.31 hours) before suffering an injury. Short track speed skating showed the longest exposure (9.80 hours), before suffering an injury. The most common anatomical areas of injury were the head, shoulder and knee (13.23%). Only nine diseases were suffered (four women and five men) of which six were infections, one was a friction burn, one was a lipothymy and one a cluster headache due to height. Conclusion In general, 6.13% of the athletes sustained at least one injury and 0.81% a disease, which is a much lower percentage than that recorded in similar events. The incidence of injuries and diseases varied among sport specialities. PMID:28879023

Sports injuries and illnesses during the Granada Winter Universiade 2015.

PubMed

Gallo-Vallejo, Miguel Ángel; de la Cruz-Márquez, Juan Carlos; de la Cruz-Campos, Adrián; de la Cruz-Campos, Juan Carlos; Pestaña-Melero, Francisco Luis; Carmona-Ruiz, Ginés; Gallo-Galán, Luz María

2016-01-01

To analyse the incidence of diseases and injuries suffered by athletes participating in the 27th Winter Sports Universiade held in Granada, Spain. The daily occurrence of injuries and diseases was registered at the point of first aid (Borreguiles, 2665 metres above sea level (masl)) and in the clinic of Pradollano (2017 masl), both in Sierra Nevada, as well as in medical services provided by the organising committee of Granada 2015 Universiade and located in sport pavilions in which indoor competitions are held. A total of 1109 athletes (650 men, 58.61%; 459 women, 41.39%). Nine diseases and 68 injuries were recorded. In total, the rate of injury was 6.13% (7.07% for men and 4.79% for women). The percentage of injury was highest in alpine skiing (10.34%) followed by freestyle skiing (8.62%). In relation to the time of exposure, freestyle skiing showed the shortest time of exposure (0.31 hours) before suffering an injury. Short track speed skating showed the longest exposure (9.80 hours), before suffering an injury. The most common anatomical areas of injury were the head, shoulder and knee (13.23%). Only nine diseases were suffered (four women and five men) of which six were infections, one was a friction burn, one was a lipothymy and one a cluster headache due to height. In general, 6.13% of the athletes sustained at least one injury and 0.81% a disease, which is a much lower percentage than that recorded in similar events. The incidence of injuries and diseases varied among sport specialities.

A biomechanical model for actively controlled snow ski bindings.

PubMed

Hull, M L; Ramming, J E

1980-11-01

Active control of snow ski bindings is a new design concept which potentially offers improved protection from lower extremity injury. Implementation of this concept entails measuring physical variables and calculating loading and/or deformation in injury prone musculoskeletal components. The subject of this paper is definition of a biomechanical model for calculating tibia torsion based on measurements of torsion loading between the boot and ski. Previous control schemes have used leg displacement only to indicate tibia torsion. The contributions of both inertial and velocity-dependent torques to tibia loading are explored and it is shown that both these moments must be included in addition to displacement-dependent moments. A new analog controller design which includes inertia, damping, and stiffness terms in the tibia load calculation is also presented.

The risks and benefits of snow sports for people with disabilities: a review of the literature.

PubMed

Nasuti, Gabriella; Temple, Viviene A

2010-09-01

Snow sports are popular pastimes with therapeutic potential. The aim of this review is to evaluate the risk of injury and evidence of benefits of alpine skiing (including sit-skiing), Nordic skiing, and snowboarding for people with disabilities. Ten studies met the inclusion criteria from 357 citations. Research in this area is still in its infancy, but the risks of engaging in snow sports appear no greater than those of the general population, and there is some evidence that skiing can positively influence self-esteem, physical self-worth, standing balance, and gross motor function among individuals with a disability.

Whole-Body Vibrations Associated With Alpine Skiing: A Risk Factor for Low Back Pain?

PubMed Central

Supej, Matej; Ogrin, Jan; Holmberg, Hans-Christer

2018-01-01

Alpine skiing, both recreational and competitive, is associated with high rates of injury. Numerous studies have shown that occupational exposure to whole-body vibrations is strongly related to lower back pain and some suggest that, in particular, vibrations of lower frequencies could lead to overuse injuries of the back in connection with alpine ski racing. However, it is not yet known which forms of skiing involve stronger vibrations and whether these exceed safety thresholds set by existing standards and directives. Therefore, this study was designed to examine whole-body vibrations connected with different types of skiing and the associated potential risk of developing low back pain. Eight highly skilled ski instructors, all former competitive ski racers and equipped with five accelerometers and a Global Satellite Navigation System to measure vibrations and speed, respectively, performed six different forms of skiing: straight running, plowing, snow-plow swinging, basic swinging, short swinging, and carved turns. To estimate exposure to periodic, random and transient vibrations the power spectrum density (PSD) and standard ISO 2631-1:1997 parameters [i.e., the weighted root-mean-square acceleration (RMS), crest factor, maximum transient vibration value and the fourth-power vibration dose value (VDV)] were calculated. Ground reaction forces were estimated from data provided by accelerometers attached to the pelvis. The major novel findings were that all of the forms of skiing tested produced whole-body vibrations, with highest PSD values of 1.5–8 Hz. Intensified PSD between 8.5 and 35 Hz was observed only when skidding was involved. The RMS values for 10 min of short swinging or carved turns, as well as all 10-min equivalent VDV values exceeded the limits set by European Directive 2002/44/EC for health and safety. Thus, whole-body vibrations, particularly in connection with high ground reaction forces, contribute to a high risk for low back pain among active alpine skiers. PMID:29593563

The National Shipbuilding Research Program. Ergonomic Study of Shipbuilding and Repair

DTIC Science & Technology

2000-10-09

syndrome, tendinitis , epicondylitis, bicipital tendinitis , rotator cuff tendinitis , disorders due to repetitive trauma, repetitive motion syndrome...Health & Safety is peer of all other managing directors. Ex. Mandatory safety rotation of two months in safety patrol group for all workers. Ex...Mandatory safety rotation of two months in safety patrol group for all workers. Ex. Each team reviews each work-related injury for cause and prevention

Annual trauma load of the world's largest indoor skiing center.

PubMed

Van Laarhoven, S N; Latten, G; de Loos, E; van Hemert, W; Vles, G F

2017-04-01

There is limited data on the trauma load caused by indoor skiing centers. Therefore, all patients treated at the accident and emergency department of our level I trauma center who sustained injuries at the world's largest indoor skiing center were analyzed during a 3-year period. Business intelligence was used to identify all patients who sustained injury at SnowWorld, Landgraaf, The Netherlands, and were seen at the accident and emergency department of the Zuyderland Medical Center from January 1, 2012 till December 31, 2014. Data were collected on patient characteristics, trauma mechanism, transportation, admission, diagnostics, injury and its severity, and treatment. Of the 732 patients seen, 305 had a fracture and 80 a dislocation. Most patients were male snowboarders and most injuries were sustained during winter. More than 2000 X-rays and 100 CT scans were required. Seventy-two patients were admitted and immediate surgery was performed in 21 patients. Ten patients had Injury Severity Scores of 10 or higher. Snowboarders differed significantly from skiers on several parameters, e.g., 1 in 4 snowboarders seen had sustained a distal radius fracture compared to 1 in 100 skiers. Acquiring more insight into the characteristics of this specific patient population could benefit clinical care and help clinicians identify and target preventive strategies. IV.

The Association between Regional Environmental Factors and Road Trauma Rates: A Geospatial Analysis of 10 Years of Road Traffic Crashes in British Columbia, Canada

PubMed Central

Brubacher, Jeffrey R.; Chan, Herbert; Erdelyi, Shannon; Schuurman, Nadine; Amram, Ofer

2016-01-01

Background British Columbia, Canada is a geographically large jurisdiction with varied environmental and socio-cultural contexts. This cross-sectional study examined variation in motor vehicle crash rates across 100 police patrols to investigate the association of crashes with key explanatory factors. Methods Eleven crash outcomes (total crashes, injury crashes, fatal crashes, speed related fatal crashes, total fatalities, single-vehicle night-time crashes, rear-end collisions, and collisions involving heavy vehicles, pedestrians, cyclists, or motorcyclists) were identified from police collision reports and insurance claims and mapped to police patrols. Six potential explanatory factors (intensity of traffic law enforcement, speed limits, climate, remoteness, socio-economic factors, and alcohol consumption) were also mapped to police patrols. We then studied the association between crashes and explanatory factors using negative binomial models with crash count per patrol as the response variable and explanatory factors as covariates. Results Between 2003 and 2012 there were 1,434,239 insurance claim collisions, 386,326 police reported crashes, and 3,404 fatal crashes. Across police patrols, there was marked variation in per capita crash rate and in potential explanatory factors. Several factors were associated with crash rates. Percent roads with speed limits ≤ 60 km/hr was positively associated with total crashes, injury crashes, rear end collisions, and collisions involving pedestrians, cyclists, and heavy vehicles; and negatively associated with single vehicle night-time crashes, fatal crashes, fatal speeding crashes, and total fatalities. Higher winter temperature was associated with lower rates of overall collisions, single vehicle night-time collisions, collisions involving heavy vehicles, and total fatalities. Lower socio-economic status was associated with higher rates of injury collisions, pedestrian collisions, fatal speeding collisions, and fatal collisions. Regions with dedicated traffic officers had fewer fatal crashes and fewer fatal speed related crashes but more rear end crashes and more crashes involving cyclists or pedestrians. The number of traffic citations per 1000 drivers was positively associated with total crashes, fatal crashes, total fatalities, fatal speeding crashes, injury crashes, single vehicle night-time crashes, and heavy vehicle crashes. Possible explanations for these associations are discussed. Conclusions There is wide variation in per capita rates of motor vehicle crashes across BC police patrols. Some variation is explained by factors such as climate, road type, remoteness, socioeconomic variables, and enforcement intensity. The ability of explanatory factors to predict crash rates would be improved if considered with local traffic volume by all travel modes. PMID:27099930

Standing Height as a Prevention Measure for Overuse Injuries of the Back in Alpine Ski Racing: A Kinematic and Kinetic Study of Giant Slalom

PubMed Central

Spörri, Jörg; Kröll, Josef; Fasel, Benedikt; Aminian, Kamiar; Müller, Erich

2018-01-01

Background: In alpine ski racing, typical loading patterns of the back include a combined occurrence of spinal bending, torsion, and high peak loads. These factors are known to be associated with high spinal disc loading and have been suggested to be attributable to different types of spine deterioration. However, little is known about the effect of standing height (ie, the distance between the bottom of the running surface of the ski and the ski boot sole) on the aforementioned back loading patterns. Purpose: To investigate the effect of reduced standing height on the skier’s overall trunk kinematics and the acting ground-reaction forces in giant slalom (GS) from an overuse injury prevention perspective. Study Design: Controlled laboratory study. Methods: Seven European Cup–level athletes skied a total of 224 GS turns with 2 different pairs of skis varying in standing height. Their overall trunk movement (frontal bending, lateral bending, and torsion angles) was measured based on 2 inertial measurement units located at the sacrum and sternum. Pressure insoles were used to determine the total ground-reaction force. Results: During the turn phase in which the greatest spinal disc loading is expected to occur, significantly lower total ground-reaction forces were observed for skis with a decreased standing height. Simultaneously, the skier’s overall trunk movement (ie, frontal bending, lateral bending, and torsion angles) remained unwaveringly high. Conclusion: Standing height is a reasonable measure to reduce the skier’s overall back loading in GS. Yet, when compared with the effects achievable by increased gate offsets in slalom, for instance, the preventative benefits of decreased standing height seem to be rather small. Clinical Relevance: To reduce the magnitude of overall back loading in GS and to prevent overuse injuries of the back, decreasing standing height might be an efficient approach. Nevertheless, the clinical relevance of the current findings, as well as the effectiveness of the measure “reduced standing height,” must be verified by epidemiological studies before its preventative potential can be judged as conclusive. PMID:29344540

Prolonged mounted patrolling is a risk factor for developing knee pain in Danish military personnel deployed to the Helmand Province.

PubMed

Lundin, Christina Rydahl; Houe, T; Sevelsted, A; Nissen, L

2016-10-01

Non-battle injuries have been the leading cause of medical evacuation in the recent wars in Afghanistan and Iraq. This study investigates the hypothesis, that the occurrence of knee problems could be associated with mounted patrolling in armoured vehicles independent of other risk factors. Retrospective questionnaire-based cohort study of Danish soldiers deployed to Afghanistan during 1 February-31 July 2013. 307 soldiers included. Response rate 70%. 33% reported knee pain. Significant association between knee pain and time spent weekly on mounted patrols (OR 1.23, CI 1.07 to 1.41, p=0.003). Controlled for confounders age, body mass index and duration of military employment (OR 1.22, CI 1.06 to 1.41, p=0.006). Adjusted for confounders and all other risk factors (OR 1.25, CI 1.07 to 1.48, p=0.007). The main finding in a subset of the 33% with knee pain: Significant association between more severe knee problems with Knee injury and Osteoarthritis Outcome Score below 400 and time spent weekly on mounted patrols (OR 1.49, CI 1.17 to 1.56, p=0.002). A major concern regarding knee problems among Danish deployed military personnel is identified. The risk of suffering from knee problems and the severity of symptoms increase with the amount of time spent inside a vehicle on mounted patrols. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Sports injuries and illnesses during the Winter Olympic Games 2010.

PubMed

Engebretsen, Lars; Steffen, Kathrin; Alonso, Juan Manuel; Aubry, Mark; Dvorak, Jiri; Junge, Astrid; Meeuwisse, Willem; Mountjoy, Margo; Renström, Per; Wilkinson, Mike

2010-09-01

Identification of high-risk sports, including their most common and severe injuries and illnesses, will facilitate the identification of sports and athletes at risk at an early stage. To analyse the frequencies and characteristics of injuries and illnesses during the XXI Winter Olympic Games in Vancouver 2010. All National Olympic Committees' (NOC) head physicians were asked to report daily the occurrence (or non-occurrence) of newly sustained injuries and illnesses on a standardised reporting form. In addition, the medical centres at the Vancouver and Whistler Olympic clinics reported daily on all athletes treated for injuries and illnesses. Physicians covering 2567 athletes (1045 females, 1522 males) from 82 NOCs participated in the study. The reported 287 injuries and 185 illnesses resulted in an incidence of 111.8 injuries and 72.1 illnesses per 1000 registered athletes. In relation to the number of registered athletes, the risk of sustaining an injury was highest for bobsleigh, ice hockey, short track, alpine freestyle and snowboard cross (15-35% of registered athletes were affected in each sport). The injury risk was lowest for the Nordic skiing events (biathlon, cross country skiing, ski jumping, Nordic combined), luge, curling, speed skating and freestyle moguls (less than 5% of registered athletes). Head/cervical spine and knee were the most common injury locations. Injuries were evenly distributed between training (54.0%) and competition (46.0%; p=0.18), and 22.6% of the injuries resulted in an absence from training or competition. In skeleton, figure and speed skating, curling, snowboard cross and biathlon, every 10th athlete suffered from at least one illness. In 113 illnesses (62.8%), the respiratory system was affected. At least 11% of the athletes incurred an injury during the games, and 7% of the athletes an illness. The incidence of injuries and illnesses varied substantially between sports. Analyses of injury mechanisms in high-risk Olympic winter sports are essential to better direct injury-prevention strategies.

Analysis of a severe head injury in World Cup alpine skiing.

PubMed

Yamazaki, Junya; Gilgien, Matthias; Kleiven, Svein; McIntosh, Andrew S; Nachbauer, Werner; Müller, Erich; Bere, Tone; Bahr, Roald; Krosshaug, Tron

2015-06-01

Traumatic brain injury (TBI) is the leading cause of death in alpine skiing. It has been found that helmet use can reduce the incidence of head injuries between 15% and 60%. However, knowledge on optimal helmet performance criteria in World Cup alpine skiing is currently limited owing to the lack of biomechanical data from real crash situations. This study aimed to estimate impact velocities in a severe TBI case in World Cup alpine skiing. Video sequences from a TBI case in World Cup alpine skiing were analyzed using a model-based image matching technique. Video sequences from four camera views were obtained in full high-definition (1080p) format. A three-dimensional model of the course was built based on accurate measurements of piste landmarks and matched to the background video footage using the animation software Poser 4. A trunk-neck-head model was used for tracking the skier's trajectory. Immediately before head impact, the downward velocity component was estimated to be 8 m·s⁻¹. After impact, the upward velocity was 3 m·s⁻¹, whereas the velocity parallel to the slope surface was reduced from 33 m·s⁻¹ to 22 m·s⁻¹. The frontal plane angular velocity of the head changed from 80 rad·s⁻¹ left tilt immediately before impact to 20 rad·s⁻¹ right tilt immediately after impact. A unique combination of high-definition video footage and accurate measurements of landmarks in the slope made possible a high-quality analysis of head impact velocity in a severe TBI case. The estimates can provide crucial information on how to prevent TBI through helmet performance criteria and design.

Sport injuries in adolescents

PubMed Central

Habelt, Susanne; Hasler, Carol Claudius; Steinbrück, Klaus; Majewski, Martin

2011-01-01

In spite of the wide range of injuries in adolescents during sports activities, there are only a few studies investigating the type and frequency of sport injuries in puberty. However, this information may help to prevent, diagnose and treat sports injuries among teens. 4468 injuries in adolescent patients were treated over a ten year period of time: 66,97% were boys and 32.88% girls. The most frequent sports injuries were football (31.13%) followed by handball (8.89%) and sports during school (8.77%). The lower extremity was involved in 68.71% of the cases. Knee problems were seen in 29.79% of the patients; 2.57% spine and 1.99% head injuries. Injuries consisted primarily of distortions (35.34%) and ligament tears (18.76%); 9,00% of all injuries were fractures. We found more skin wounds (6:1) and fractures (7:2) in male patients compared to females. The risk of ligament tears was highest during skiing. Three of four ski injuries led to knee problems. Spine injuries were observed most often during horse riding (1:6). Head injuries were seen in bicycle accidents (1:3). Head injuries were seen in male patients much more often then in female patients (21:1). Fractures were noted during football (1:9), skiing (1:9), inline (2:3), and during school sports (1:11). Many adolescents participate in various sports. Notwithstanding the methodological problems with epidemiological data, there is no doubt about the large number of athletes sustain musculoskeletal injuries, sometimes serious. In most instances, the accident does not happened during professional sports and training. Therefore, school teachers and low league trainer play an important role preventing further accidence based on knowledge of individual risk patterns of different sports. It is imperative to provide preventive medical check-ups, to monitor the sport-specific needs for each individual sports, to observe the training skills as well as physical fitness needed and to evaluation coaches education. PMID:22355484

Impact of Physical Activity on Participation and Quality of Life in Individuals who use Prostheses and other Assistive Technology/Lower Extremity Prostheses versus Wheelchair for Functional Performance and Participation of Military and Veteran Personnel

DTIC Science & Technology

2007-03-01

skiing injuries in physically disabled skiers . Am J Sports Med. 1992; 20:553-557 13. Cooper RA, Thorman T, Cooper R, Dvorznak MJ, Fitzgerald SG...Laskowski ER, Murtaugh PA. Snow skiing injuries in physically disabled skiers . Am J Sports Med. 1992; 20: 553-557 8. International Paralympic Committee...competitive skier with a disability. Am J Sports Med. 1992; 20: 55-60 10. Kirkby RJ, Cull J, Foreman P. Association of prelesion sports participation and

How I Manage Abdominal Injuries.

ERIC Educational Resources Information Center

Haycock, Christine E.

1986-01-01

In sports, abdominal injuries occur most frequently in cycling, horseback riding, and skiing. Most involve children, not adults. Any athlete sustaining a severe blow to the abdomen should be examined. Guidelines are provided for recognizing and treating injuries to the abdominal muscles, kidneys, spleen, and liver. (Author/MT)

High incidence of injury at the Sochi 2014 Winter Paralympic Games: a prospective cohort study of 6564 athlete days.

PubMed

Derman, W; Schwellnus, M P; Jordaan, E; Runciman, P; Van de Vliet, P; Blauwet, C; Webborn, N; Willick, S; Stomphorst, J

2016-09-01

To describe the epidemiology of injuries at the Sochi 2014 Winter Paralympic Games. A total of 547 athletes from 45 countries were monitored daily for 12 days during the Sochi 2014 Winter Paralympic Games (6564 athlete days). Daily injury data were obtained from teams with their own medical support (32 teams, 510 athletes) and teams without their own medical support (13 teams, 37 athletes) through electronic data capturing systems. There were 174 total injuries reported, with an injury incidence rate (IR) of 26.5 per 1000 athlete days (95% CI 22.7% to 30.8%). There was a significantly higher IR recorded in alpine skiing/snowboarding (IR of 41.1 (95% CI 33.7% to 49.6%) p=0.0001) compared to cross-country skiing/biathlon, ice sledge hockey or wheelchair curling. Injuries in the shoulder region were the highest single-joint IR (IR of 6.4 (95% CI 4.6% to 8.6%)), although total upper and lower body IR were similar (IR 8.5 vs 8.4 (95% CI 6.4% to 11.1%)). Furthermore, the IR of acute injuries was significantly higher than other types of injury onset (IR of 17.8 (95% CI 14.7% to 21.4%)). In a Winter Paralympic Games setting, athletes report higher injury incidence than do Olympic athletes or athletes in a Summer Paralympic Games setting. The highest incidence of injury was reported in the alpine skiing/snowboarding sporting category. There was a similar incidence of injury in the upper and lower limbs. The joint with the greatest rate of injury reported was the shoulder joint. Our data can inform injury prevention programmes and policy considerations regarding athlete safety in future Winter Paralympic Games. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Forensic epidemiologic and biomechanical analysis of a pelvic cavity blowout injury associated with ejection from a personal watercraft (jet-ski).

PubMed

Freeman, Michael D; Everson, Todd M; Kohles, Sean S

2013-01-01

Jet-propelled personal watercraft (PWC) or jet-skis have become increasingly popular. The means of propulsion of PWC, which is a jet of water forced out of small nozzle at the rear of the craft, combined with a high risk of falling off of the seat and into close proximity with the water jet stream, raise the potential for a unique type of injury mechanism. The most serious injuries associated with PWC falls are those that occur when the perineum passes in close proximity to the jet nozzle and the high-pressure water stream enters the vaginal or rectal orifice. We describe the forensic investigation into a case of an anovaginal "blowout" injury in a passenger who was ejected from the rear seat position of a PWC and subsequently suffered life-threatening injuries to the pelvic organs. The investigation included a biomechanical analysis of the injury mechanism, a summary of prior published reports of internal pelvic injuries resulting from PWC falls as well as other water sports and activities, and a comparison of the severity of the injuries resulting from differing mechanisms using the New Injury Severity Score (NISS). The mean (± standard deviation [SD]) NISS values for reported PWC injuries [not including the NISS of 38 in this case study] were 11.2 (± 9.5), while the mean value for reported water-skiing falls was half that of the PWC group at 5.6 (± 5.2). It was concluded that the analyzed injuries were unique to a PWC ejection versus other previously described non-PWC-associated water sport injuries. It is recommended that PWC manufacturers help consumers understand the potential risks to passengers with highly visible warnings and reduce injury risk with revised seat design, and/or passenger seat "deadman" switches. © 2012 American Academy of Forensic Sciences.

Social Support and Recovery from Sport Injury: Elite Skiers Share Their Experiences.

ERIC Educational Resources Information Center

Bianco, Theresa

2001-01-01

Interviewed elite skiers who had recovered from serious injuries about stress associated with injury and the role of social support in recovery. Skiers needed various types of emotional, informational, and tangible support from the occurrence of injury through the return to full activity. Treatment team members, ski team members and home support…

Searching hospital discharge records for snow sport injury: no easy run?

PubMed

Smartt, Pamela F M; Chalmers, David J

2012-01-01

When using hospital discharge data to shape sports injury prevention policy, it is important to correctly identify cases. The objectives of this study were to examine the ease with which snow-skiing and snowboarding injury cases could be identified from national hospital discharge data and to assess the suitability of the information obtained for shaping policy. Hospital discharges for 2000-2004 were linked to compensated claims and searched sequentially using coded and narrative information. One thousand three hundred seventy-six eligible cases were identified, with 717 classified as snowboarding and 659 as snow-skiing. For the most part, cases could not be identified and distinguished using simple searches of coded data; keyword searches of narratives played a key role in case identification but not in describing the mechanism of injury. Identification and characterisation of snow sport injury from in-patient discharge records is problematic due to inadequacies in the coding systems and/or their implementation. Narrative reporting could be improved.

Comparison of tibial shaft ski fractures in children and adults.

PubMed

Hamada, Tomo; Matsumoto, Kazu; Ishimaru, Daichi; Sumi, Hiroshi; Shimizu, Katsuji

2014-09-01

To examine whether child and adult skiers have different risk factors or mechanisms of injury for tibial shaft fractures. Descriptive epidemiological study. Prospectively analyzed the epidemiologic factors, injury types, and injury mechanisms at Sumi Memorial Hospital. This study analyzed information obtained from 276 patients with tibial fractures sustained during skiing between 2004 and 2012. We focused on 174 ski-related tibial shaft fractures with respect to the following factors: age, gender, laterality of fracture, skill level, mechanism of fracture (fall vs collision), scene of injury (steepness of slope), snow condition, and weather. Fracture pattern was graded according to Arbeitsgemeinschaft für Osteosynthesefragen (AO) classification and mechanical direction [external (ER) or internal rotation (IR)]. Tibial shaft fractures were the most common in both children (89.3%) and adults (47.4%). There were no significant differences in gender, side of fracture, mechanism of fracture, snow condition, or weather between children and adults. Skill levels were significantly lower in children than in adults (P < 0.0001). Type A fractures were more dominant in children (73 cases, 72.3%) than in adults (39 cases, 53.4%). There was significantly more ER in children than in adults (P < 0.0001). Among children, female patients had significantly more IR than ER; in contrast, among adults, women were injured by ER. We found significant differences in some of these parameters, suggesting that child and adult skiers have different risk factors or mechanisms of injury for tibial shaft fractures.

Let it snow: how snowfall and injury mechanism affect ski and snowboard injuries in Vail, Colorado, 2011-2012.

PubMed

Moore, S Jason; Knerl, Dana

2013-08-01

Current research examining the impact of mechanism of injury and daily snowfall amounts on injury severity among skiers and snowboarders is limited. The purpose of this study was to define correlations between injury mechanism and daily snowfall on injury patterns and severity among skiers and snowboarders. This observational study analyzed daily snowfall measurements coupled with trauma admissions during the 2011 and 2012 ski seasons from a Level III trauma center servicing a large North American ski resort. Post hoc adjusted analyses and multivariate modeling was used to determine independent predictors of increased injury severity. Six hundred forty-four trauma admissions were analyzed, with primary research considerations detailing the variances in injury severity resulting from collisions with other skiers or snowboarders and daily total snowfall. Findings demonstrated that collisions were independently associated with increased (1) injury severity (Injury Severity Score [ISS ≥ 16]) (odds ratio [OR], 3.9; 95% confidence interval [CI], 2.0-7.6; p < 0.001), (2) thoracic injury severity (Abbreviated Injury Scale [AIS] score ≥ 3) (OR, 7.5; 95% CI, 3.7-15.0; p < 0.001), and (3) renal injuries (OR, 3.2; 95% CI, 1.2-8.1; p = 0.017) as well as and axial skeleton fractures (OR, 4.5; 95% CI, 2.6-7.7; p < 0.001). In addition, mean ISS was significantly higher in the setting of a collision when compared with a fall (8.6 vs. 5.8; p < 0.001). Findings regarding total snowfall demonstrate a negative correlation between snowfall and injury severity (r = -0.08, p = 0.05); the majority (65.5%) of injuries were sustained when there was 1 inch or less of recent snowfall, and a snowfall total of 2 inches or less was independently associated with increased injury severity (ISS ≥ 16) (OR, 3.1; 95% CI, 1.1-9.1; p = 0.036). Collisions between snowsport enthusiasts and total trace snowfall predict an increase in injury severity among alpine skiers and snowboarders. Findings from this project may lead to an increased understanding of predictive factors contributing to injury, alter the diagnostic evaluation of patients, provide educational opportunities for alpine enthusiasts, and enhance resort safety initiatives tailored to ambient conditions.

Advanced patrol routing with on-call response for effective resource management.

DOT National Transportation Integrated Search

2011-12-01

Traffic incidents not only greatly impact individuals, but also affect the general population. : Depending on the incident severity, incidents are likely to cause both private and public property : damage and possibly cause injury and fatalities. Due...

Injuries and illnesses in working dogs used during the disaster response after the bombing in Oklahoma City.

PubMed

Duhaime, R A; Norden, D; Corso, B; Mallonee, S; Salman, M D

1998-04-15

To determine characteristics of working dogs used during the disaster response after the bombing in Oklahoma City and risk factors for injuries and illnesses of those dogs, and to document recommendations for future disaster responses. Survey. Information for 74 working dogs used at the bombing site. Dog handlers were identified and asked to complete a questionnaire. Questions were asked about the training and use of each dog, use of paw protection, injuries and illnesses incurred, possible effects after completion of duty at Oklahoma City, and handler's experience. Data were obtained for all 74 dogs used at the site. Handlers of 69 of 74 (93%) dogs responded. The dogs had been extensively trained and were used 491 dog-days at the site, with 46 dogs used in search, 14 in patrol, 12 in explosive-detection duty, and 2 in search/patrol. Fifteen (22%) dogs became ill. Nineteen (28%) dogs incurred 20 injuries. Footpad injuries constituted 18 of the injuries. Only 16 of 69 (23%) dogs were provided with paw protection. Dogs were more likely to be injured when they were used in a search capacity, were used during the first 2 days after the bombing, were German Shepherd Dogs, or were older. Although working in a high-risk environment, injuries to dogs were few, and most were minor. Specific recommendations could facilitate use of dogs in disaster situations and improve safety for those dogs.

[Fractures of the lower leg in professional skiers].

PubMed

Mückley, T; Kruis, C; Schütz, T; Brucker, P; Bühren, V

2004-03-01

Fractures of the lower leg due to skiing accidents remain an important concern. Few studies have focussed on the special demands of professional athletes who sustain these injuries. We present our experience with three cases of lower leg fractures in competitive professional downhill skiers and discuss management and treatment concepts. We performed limited reamed compression nailing in all the patients presented because it offers the advantages of high mechanical stability and optimized fragment apposition. Plate osteosynthesis of the fibula is not required in most typical fractures. All patients resumed ski training. Two of them returned to World Cup. Only one achieved her pre-injury World Cup level of performance and success. In conclusion, a successful return for professional skiers with lower leg fractures is feasible using an optimized treatment strategy.

Meteorological variables associated with deep slab avalanches on persistent weak layers

USGS Publications Warehouse

Marienthal, Alex; Hendrikx, Jordy; Birkeland, Karl; Irvine, Kathryn M.

2014-01-01

Deep slab avalanches are a particularly challenging avalanche forecasting problem. These avalanches are typically difficult to trigger, yet when they are triggered they tend to propagate far and result in large and destructive avalanches. For this work we define deep slab avalanches as those that fail on persistent weak layers deeper than 0.9m (3 feet), and that occur after February 1st. We utilized a 44-year record of avalanche control and meteorological data from Bridger Bowl Ski Area to test the usefulness of meteorological variables for predicting deep slab avalanches. As in previous studies, we used data from the days preceding deep slab cycles, but we also considered meteorological metrics over the early months of the season. We utilized classification trees for our analyses. Our results showed warmer temperatures in the prior twenty-four hours and more loading over the seven days before days with deep slab avalanches on persistent weak layers. In line with previous research, extended periods of above freezing temperatures led to days with deep wet slab avalanches on persistent weak layers. Seasons with either dry or wet avalanches on deep persistent weak layers typically had drier early months, and often had some significant snow depth prior to those dry months. This paper provides insights for ski patrollers, guides, and avalanche forecasters who struggle to forecast deep slab avalanches on persistent weak layers late in the season.

A population-based study of sport and recreation-related head injuries treated in a Canadian health region.

PubMed

Harris, Andrew W; Jones, C Allyson; Rowe, Brian H; Voaklander, Donald C

2012-07-01

To report the rates of SR-related HIs presenting to EDs in a Canadian population-based sample. Descriptive epidemiology study. Using administrative data, sport and recreation-related emergency department presentations for persons 0-35 years of age, from April 1997 through March 2008, were obtained from the Edmonton Zone (formerly the Capital Health Region), Alberta Health Services through the Ambulatory Care Classification System. Of the 3,230,890 visits to the emergency departments of the five hospitals in Edmonton, 63,219 sport and recreation-related injury records and 4935 sport and recreation-head injury records were identified. Head injuries were most frequently treated for the activities of hockey (20.7%), cycling (12.0%), and skiing/snowboarding/sledding. Males accounted for 71.9% (n=3546) and patients less than 18 years of age sustained 3446 (69.8%) sport and recreation-head injuries. Sport and recreation-related head injuries most frequently treated in emergency departments involve common activities such as hockey, cycling, skiing/snowboarding/sledding, and soccer. Males and those less than 18 years of age sustain the majority of sport and recreation-related head injuries treated in emergency departments. These findings underscore the importance of sport-specific policies and safety promotion for the prevention of head injuries, in sports and recreational activities. Copyright © 2011 Sports Medicine Australia. All rights reserved.

Facial Sports Injuries

MedlinePlus

... high speed or contact sports, such as boxing, football, soccer, ice hockey, bicycling skiing, and snowmobiling. Most ... protective equipment - such as helmets and padding for football, bicycling and rollerblading; face masks, head and mouth ...

Epidemiology of Feature-Specific Injuries Sustained by Skiers in a Snow Park.

PubMed

Carús, Luis; Escorihuela, María

2016-09-01

The objective of the present case series study was to analyze injury types and injured anatomic locations resulting from skiing in snow park (SP) features and to determine potential risk factors for ski injuries in an SP. The study was conducted during the 2013-2014 winter season in the SP of a major winter resort located in the Spanish Pyrenees. Cases involved skiers who experienced feature-related injuries in the SP. A total of 113 cases met the inclusion criteria. Logistic regression was used to calculate the odds of injury types and injury to anatomic locations on aerial versus nonaerial features. The overall injury rate was 0.9 per 1000 skier runs. The proportion of injuries was higher for aerials (1.18% of uses) than for nonaerials (0.66% of uses). Results revealed that the upper extremities were the most commonly injured body region, and sprains/strains/dislocations and fractures were the most common injury type. The most commonly injured anatomic location on nonaerial features was the face, while on aerial features it was the head. A higher proportion of fractures was observed on aerial features, while a higher proportion of sprains/strains/dislocations was observed on nonaerial features. Prevention strategies to reduce injury risk include SP redesign, safety and communication policies, instruction on technical skills, and promotion of the use of protective equipment. Copyright © 2016 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

Sports and Exercise Safety

MedlinePlus

... risk of injury almost as much as playing football without shoulder pads? Using the wrong — or not ... helmets : They're important for sports such as football , hockey, baseball, softball, biking, skateboarding, inline skating, skiing , ...

Anterior cruciate ligament (ACL) injury

MedlinePlus

... side of your knee, such as during a football tackle Overextend your knee joint Quickly stop moving ... running, landing from a jump, or turning Basketball, football, soccer, and skiing are common sports linked to ...

Physician-directed injury prevention for young skiers and snowboarders

PubMed Central

Macnab, Andrew J; Cadman, Robert E; Greenlaw, Julia V

1998-01-01

Based on earlier studies of ski injury, which indicated that youths were at increased risk of injury, that males were most likely to injure the head or face and that females were most likely to injure the knee, a study to identify factors relevant for physicians to use in injury prevention initiatives was undertaken. The authors then conducted a search for effective injury prevention strategies using MEDLINE. The results of both undertakings were the basis for proposed guidelines for prevention strategies that physicians can use when counselling skiers and snowboarders. PMID:20401274

Epidemiology and mortality of glacier crevasse accidents.

PubMed

Pasquier, Mathieu; Taffé, Patrick; Kottmann, Alexandre; Mosimann, Ueli; Reisten, Oliver; Hugli, Olivier

2014-11-01

Crevasse accidents can lead to severe injuries and even death, but little is known about their epidemiology and mortality. We retrospectively reviewed helicopter-based emergency services rescue missions for crevasse victims in Switzerland between 2000 and 2010. Demographic and epidemiological data were collected. Injury severity was graded according to the National Advisory Committee for Aeronautics (NACA) score. A total of 415 victims of crevasse falls were included in the study. The mean victim age was 40 years (SD 13) (range 6-75), 84% were male, and 67% were foreigners. The absolute number of victims was much higher during the months of March, April, July, and August, amounting to 73% of all victims; 77% of victims were practicing mountaineering or ski touring. The mean depth of fall was 16.5m (SD 9.0) (range 1-35). Overall on-site mortality was 11%, and it was higher during the ski season than the ski offseason (14% vs. 7%; P=0.01), for foreigners (14% vs. 5%; P=0.01), and with higher mean depth of fall (22 vs. 15m; P=0.01). The NACA score was ≥4 for 22% of the victims, indicating potential or overt vital threatening injuries, but 24% of the victims were uninjured (NACA 0). Multivariable analyses revealed that depth of the fall, summer season, and snowshoeing were associated with higher NACA scores, whereas depth of the fall, snowshoeing, and foreigners but not season were associated with higher risk of death. The clinical spectrum of injuries sustained by the 415 patients in this study ranged from benign to life-threatening. Death occurred in 11% of victims and seems to be determined primarily by the depth of the fall. Copyright © 2014 Elsevier Ltd. All rights reserved.

Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils.

PubMed

Itagaki, Kiyoshi; Zhang, Qin; Hauser, Carl J

2010-04-01

Inflammation and microvascular thrombosis are interrelated causes of acute lung injury in the systemic inflammatory response syndrome. Neutrophils (polymorphonuclear neutrophil [PMN]) and endothelial cells (EC) activated by systemic inflammatory response syndrome interact to increase pulmonary vascular permeability, but the interactions between PMN and EC are difficult to study. Recently, we reported that sphingosine 1-phosphate is a second messenger eliciting store-operated calcium entry (SOCE) in response to inflammatory agonists in both PMN and EC. Store-operated calcium entry is therefore a target mechanism for the therapeutic modulation of inflammatory PMN-EC interactions. Here, we isolated, modeled, and studied the effects of pharmacologic SOCE inhibition using real-time systems to monitor EC permeability after exposure to activated PMN. We created systems to continuously assess permeability of human pulmonary artery endothelial cells and human microvascular endothelial cells from lung. Endothelial cells show increased permeability after challenge by activated PMN. Such permeability increases can be attenuated by exposure of the cocultures to sphingosine kinase (SK) inhibitors (SKI-2, N,N-dimethylsphingosine [DMS]) or Ca2+ entry inhibitors (Gd3+, MRS-1845). Human microvascular endothelial cells from lung pretreated with SKI-2 or DMS showed decreased permeability when later exposed to activated PMN. Likewise, when PMNs were activated with thapsigargin (TG) in the presence of SKI-2, DMS, Gd, or MRS-1845, their ability to cause EC permeability subsequently was reduced. SKI-2 also inhibited the activation of human pulmonary artery ECs by thrombin. These studies will provide a firm mechanistic foundation for understanding how systemic SOCE inhibition may be used to prevent acute lung injury in vivo.

Sports Injury and Illness Epidemiology: Great Britain Olympic Team (TeamGB) surveillance during the Sochi 2014 Winter Olympic Games

PubMed Central

Palmer-Green, Debbie; Elliott, Niall

2015-01-01

Background Sports injury and illness surveillance is the first step in injury and illness prevention, and is important for the protection of both athlete health and performance in major competitions. Aim To identify the prevalence, severity nature and causes of athlete injuries and illnesses in the Great Britain Olympic Team (TeamGB) during the Sochi 2014 Winter Olympic Games. Methods The observational prospective cohort study followed the Great Britain Injury/Illness Performance Project surveillance methodology and obtained information on injuries and illnesses that occurred during the Games between 30 January and 23 February 2014 in TeamGB athletes (n=56). Results Among the 56 TeamGB athletes, there were 27 injuries and 11 illnesses during the Olympic Games period. This equated to 39% sustaining at least one injury and 18% at least one illness, with an incidence of 48.2 injuries and 19.6 illnesses per 100 athletes, respectively. Of all injuries and illnesses, 9% and 7%, respectively, resulted in time loss. The risk of sustaining an injury was highest for freestyle skiing, skeleton and snowboarding; and lowest for curling, biathlon and Alpine skiing (with no reported injuries); with the lower limb being the most commonly injured location. Respiratory system illnesses were most frequently reported overall, and older female athletes were the ones most affected by illness. Conclusions The risk of injury was double the risk of illness for TeamGB athletes. Overall, the rate of time-loss issues was low. Methodological considerations are important when interpreting data, and prevention strategies should focus on those issues causing the greatest risk, in terms of prevalence and severity, to athlete health and performance. PMID:25425714

Helmet use and injury severity among pediatric skiers and snowboarders in Colorado.

PubMed

Milan, Melissa; Jhajj, Sandeep; Stewart, Camille; Pyle, Laura; Moulton, Steven

2017-02-01

Skiing and snowboarding are popular winter recreational activities that are commonly associated with orthopedic type injuries. Unbeknownst to most parents, however, are the significant but poorly described risks for head, cervical spine and solid organ injuries. Although helmet use is not mandated for skiers and snowboarders outside of resort sponsored activities, we hypothesized that helmet use is associated with a lower risk of severe head injury, shorter ICU stay and shorter hospital length of stay. The trauma registry at a level I pediatric trauma center in the state of Colorado was queried for children ages 3-17years, who sustained an injury while skiing or snowboarding from 1/1/1999 to 12/31/2014. Injury severity was assessed by Abbreviated Injury Severity (AIS) score, injury severity score (ISS) and admission location. Head injury was broadly defined as any trauma to the body above the lower border of the mandible. Regression analysis was used to test associations of variables with injury severity. 549 children sustained snow sport related injuries during the 16year study period. The mean patient age was11±3years, most were male (74%) and the majority were Colorado residents (54%). The overall median ISS was 9 (IQR 4-9) and 78 children (14%) were admitted to the ICU. Colorado residents were nearly twice as likely to be wearing a helmet at the time of injury, compared to visitors from out-of-state (adjusted OR 1.86, 95% CI 1.24-2.76, p=0.002). In a multivariate analysis injury severity was significantly associated with injury while skiing (p=0.026), helmet use (p=0.0416), and sustaining a head injury (p<0.0001). In a separate multivariate analysis ICU admission was associated with head injury (p<0.0001) and wearing a helmet (p=0.0257); however, those wearing a helmet and admitted to the ICU had significantly lower ISS (p=0.007) and head AIS (p=0.011) scores than those who were not wearing a helmet at the time of injury. Visitors from out of state were less likely to be wearing a helmet when injured and more likely to be severely injured, suggesting Colorado residents have a better understanding of the benefits of helmet usage. Helmeted skiers and snowboarders who were admitted to the ICU had significantly lower ISS and head AIS scores than those who were not helmeted. Pediatric skiers, snowboarders and their parents should be educated on the significant risks associated with these activities and the benefits of helmet usage. III. Copyright © 2016 Elsevier Inc. All rights reserved.

[Ski boots versus the knee joint. 2: What produces the forward leaning position of the ski boot?].

PubMed

Schaff, P; Hauser, W

1990-03-01

In contrast to the drop in the incidence of fracture of the lower leg that has been observed in recent years, the incidence of knee injuries has not decreased in skiing. There has even been a relative increase of severe knee lesions and isolated ACL ruptures, prompting us to conduct a comprehensive study of the causes of this phenomena. The goal of part 2 of the study was to comprehensively examine the forward movement in skiboots in the lab and on the slope. Studying nine beginners and eight experts, we found a 20% (sign. 0.05) lower forward-lean capability for the beginner group in the same boot. A randomized study with crossover design conducted on the slope, where we equipped 16 skiers with either soft or stiff boots for the duration of five ski days, revealed the learning behaviour and forward position on the slope depending on the boot. The pupils became definitely less adept at learning if they were required to wear stiff skiboots and showed a sign, lower forward flex angle. A skiiing style in backward lean position was adopted and supported by the fixed backward spoiler. Therefore another study was necessary and will follow (part 3) to examine the effect of a stiff backward spoiler and skiing in a backward lean position. In consideration of the facts known up to now, it is concluded that to improve safety in skiing recommendations must be given as to which boot to choose, according to the skiing level. In addition, the setting of safety bindings must consider the type of skiboot used.

Shoulder and Lower Back Joint Reaction Forces in Seated Double Poling.

PubMed

Lund Ohlsson, Marie; Danvind, Jonas; Holmberg, L Joakim

2018-04-13

Overuse injuries in the shoulders and lower back are hypothesized to be common in cross-country sit-skiing. Athletes with reduced trunk muscle control mainly sits with their knees higher than hips (KH). To reduce spinal flexion, a position with the knees below the hips (KL) was enabled for these athletes using a frontal trunk support. The aim of the study was to compare the shoulder joint (glenohumeral joint) and L4-L5 joint reactions between the sitting positions KL and KH. Five able-bodied female athletes performed submaximal and maximal exercise tests in the sitting positions KL and KH on a ski-ergometer. Measured pole forces and 3-dimensional kinematics served as input for inverse-dynamics simulations to compute the muscle forces and joint reactions in the shoulder and L4-L5 joint. This was the first musculoskeletal simulation study of seated double poling. The results showed that the KH position was favorable for higher performance and decreased values of the shoulder joint reactions for female able-bodied athletes with full trunk control. The KL position was favorable for lower L4-L5 joint reactions and might therefore reduce the risk of lower back injuries. These results indicate that it is hard to optimize both performance and safety in the same sit-ski.

Self-reported musculoskeletal complaints and injuries and exposure of physical workload in Swedish soldiers serving in Afghanistan

PubMed Central

Hagman, Ingela; Tegern, Matthias; Broman, Lisbet; Larsson, Helena

2018-01-01

Background Musculoskeletal complaints and injuries (MSCI) are common in military populations. However, only a limited number of studies have followed soldiers during international deployments and investigated the prevalence of MSCI during and at the end of their deployment. The aim was to describe the prevalence of MSCI in different military occupational specialties and categorise their most common tasks in terms of exposures to physical workloads during a six-month long international deployment in Afghanistan. Methods Cross-sectional survey, including 325 soldiers (300 men), aged 20–62 participating in an international deployment in Afghanistan during the spring of 2012. Soldiers were clustered into different military occupational specialties: Infantry, Administration, Logistics, Logistics/Camp, Medical and Other. Data were collected through the use of the Musculoskeletal Screening Protocol at the end of the international mission. Results Forty-seven percent reported MSCI during deployment, with 28% at the end. The most common locations of MSCI during the mission were lower back, knee, shoulders, upper back, neck and foot, while the knee and lower back prevailed at the end of the mission. Almost half of the soldiers who had MSCI reported affected work ability. The most common duties during the mission were vehicle patrolling, staff duties, guard/security duties, foot patrols and transportation. Soldiers reported that vehicle patrolling, staff duties and transportation were demanding with respect to endurance strength, guard/security duties challenged both maximum and endurance strength while foot patrolling challenged maximum and endurance strength, aerobic and anaerobic endurance and speed. Conclusions MSCI during international deployment are common among Swedish soldiers. The results indicate the need to further develop strategies focusing on matching the soldiers’ capacity to the job requirements, with relevant and fair physical selection-tests during the recruitment process and proactive interventions targeting MSCI before and during deployment, in order to enhance soldiers’ readiness and promote operational readiness. PMID:29621324

Propeller injuries.

PubMed

Mann, R J

1976-05-01

Water skiing, boat racing, skin and scuba diving, and pleasure boat cruising are increasing in popularity. As a result the incidence of injuries secondary to motor propellers is becoming more frequent. In a ten-year period from 1963 to 1973, I collected a total of nine cases. In some amputations were necessary, and in other cases amputations occurred at the time of injury. Problems with bacterial flora occurring in open sea water versus salt water enclosed near docks and fresh lake water are discussed. A review of the orthopedic literature revealed sparse information regarding propeller injuries.

Adventure and Extreme Sports.

PubMed

Gomez, Andrew Thomas; Rao, Ashwin

2016-03-01

Adventure and extreme sports often involve unpredictable and inhospitable environments, high velocities, and stunts. These activities vary widely and include sports like BASE jumping, snowboarding, kayaking, and surfing. Increasing interest and participation in adventure and extreme sports warrants understanding by clinicians to facilitate prevention, identification, and treatment of injuries unique to each sport. This article covers alpine skiing and snowboarding, skateboarding, surfing, bungee jumping, BASE jumping, and whitewater sports with emphasis on epidemiology, demographics, general injury mechanisms, specific injuries, chronic injuries, fatality data, and prevention. Overall, most injuries are related to overuse, trauma, and environmental or microbial exposure. Copyright © 2016 Elsevier Inc. All rights reserved.

Crash Injury Management for Traffic Law Enforcement Officers; Emergency Medical Services; Course Guide.

ERIC Educational Resources Information Center

Cleven, Arlene M.

The course guide has been prepared to aid in planning and conducting a training program in emergency medical care for first responders to traffic accidents (expected to be patrolling law enforcement officers). This document contains a detailed description of the training program; suggestions for course planning including class size, scheduling…

Helmet use and reduction in skull fractures in skiers and snowboarders admitted to the hospital.

PubMed

Rughani, Anand I; Lin, Chih-Ta; Ares, Wiliam J; Cushing, Deborah A; Horgan, Michael A; Tranmer, Bruce I; Jewell, Ryan P; Florman, Jeffrey E

2011-03-01

Helmet use has been associated with fewer hospital visits among injured skiers and snowboarders, but there remains no evidence that helmets alter the intracranial injury patterns. The authors hypothesized that helmet use among skiers and snowboarders reduces the incidence of head injury as defined by findings on head CT scans. The authors performed a retrospective review of head-injured skiers and snowboarders at 2 Level I trauma centers in New England over a 6-year period. The primary outcome of interest was intracranial injury evident on CT scans. Secondary outcomes included the following: need for a neurosurgical procedure, presence of spine injury, need for ICU admission, length of stay, discharge location, and death. Of the 57 children identified who sustained a head injury while skiing or snowboarding, 33.3% were wearing a helmet at the time of injury. Of the helmeted patients, 5.3% sustained a calvarial fracture compared with 36.8% of the unhelmeted patients (p = 0.009). Although there was a favorable trend, there was no significant difference in the incidence of epidural hematoma, subdural hematoma, intraparenchymal hemorrhage, subarachnoid hemorrhage, or contusion in helmeted and unhelmeted patients. With regard to secondary outcomes, there were no significant differences between the 2 groups in percentage of patients requiring neurosurgical intervention, percentage requiring admission to an ICU, total length of stay, or percentage discharged home. There was no difference in the incidence of cervical spine injury. There was 1 death in an unhelmeted patient, and there were no deaths among helmeted patients. Among hospitalized children who sustained a head injury while skiing or snowboarding, a significantly lower number of patients suffered a skull fracture if they were wearing helmets at the time of the injury.

Paralysis from sport and diving accidents.

PubMed

Schmitt, H; Gerner, H J

2001-01-01

To examine the causes of sport-related spinal cord injuries that developed into paraplegia or tetraplegia, and to compare data from different sports with previous studies in the same geographical region. A retrospective epidemiological study and comparison with previous studies. The Orthopedic Department, specializing in the treatment and rehabilitation of paralyzed patients, at the University of Heidelberg, Germany. Between 1985 and 1997, 1,016 cases of traumatic spinal cord injury presented at the Orthopedic Department at the University of Heidelberg: 6.8% were caused by sport and 7.7% by diving accidents. Sport-related spinal cord injuries with paralysis. A total of 1.016 cases of traumatic spinal cord injury were reviewed. Of these, 14.5% were caused by sport accidents (n = 69) or diving accidents (n = 78). Age of patients ranged from 9 to 52 years. 83% were male. 77% of the patients developed tetraplegia, and 23%, paraplegia. 16 of the sport accidents resulted from downhill skiing, 9 resulted from horseback riding, 7 from modern air sports, 6 from gymnastics, 5 from trampolining, and 26 from other sports. Previous analyses had revealed that paraplegia had mainly occurred from gymnastics, trampolining, or high diving accidents. More recently, however, the number of serious spinal injuries caused by risk-filled sports such as hang gliding and paragliding has significantly increased (p = 0.095), as it has for horseback riding and skiing. Examinations have shown that all patients who were involved in diving accidents developed tetraplegia. An analysis of injury from specific sports is still under way. Analysis of accidents resulting in damage to the spinal cord in respect to different sports shows that sports that have become popular during the last 10 years show an increasing risk of injury. Modern air sports hold the most injuries. Injury-preventing strategies also are presented.

Management of Syndesmotic Ankle Injuries in Children and Adolescents.

PubMed

Shore, Benjamin J; Kramer, Dennis E

2016-06-01

Pediatric ankle injuries are common, especially in athletes; however, the incidence of syndesmosis injuries in children has been scarcely reported. Injuries to the ankle syndesmosis, termed "high ankle sprains," can affect high-level and recreational athletes and have been related to delayed return to play, persistent pain, and adult injuries have been associated with long-term disability. Syndesmotic injuries do occur in children, especially those who participate in sports that involve cutting and pivoting (football, soccer) or sports with rigid immobilization of the ankle (skiing, hockey). Unstable pediatric syndesmosis injuries requiring surgical fixation are often associated with concomitant fibular fracture in skeletally mature children. Physician vigilance and careful clinical examination coupled with appropriate radiographs can determine the extent of the injury in the majority of circumstances.

Relationship between jump landing kinematics and peak ACL force during a jump in downhill skiing: a simulation study.

PubMed

Heinrich, D; van den Bogert, A J; Nachbauer, W

2014-06-01

Recent data highlight that competitive skiers face a high risk of injuries especially during off-balance jump landing maneuvers in downhill skiing. The purpose of the present study was to develop a musculo-skeletal modeling and simulation approach to investigate the cause-and-effect relationship between a perturbed landing position, i.e., joint angles and trunk orientation, and the peak force in the anterior cruciate ligament (ACL) during jump landing. A two-dimensional musculo-skeletal model was developed and a baseline simulation was obtained reproducing measurement data of a reference landing movement. Based on the baseline simulation, a series of perturbed landing simulations (n = 1000) was generated. Multiple linear regression was performed to determine a relationship between peak ACL force and the perturbed landing posture. Increased backward lean, hip flexion, knee extension, and ankle dorsiflexion as well as an asymmetric position were related to higher peak ACL forces during jump landing. The orientation of the trunk of the skier was identified as the most important predictor accounting for 60% of the variance of the peak ACL force in the simulations. Teaching of tactical decisions and the inclusion of exercise regimens in ACL injury prevention programs to improve trunk control during landing motions in downhill skiing was concluded. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The Use of Body Worn Sensors for Detecting the Vibrations Acting on the Lower Back in Alpine Ski Racing.

PubMed

Spörri, Jörg; Kröll, Josef; Fasel, Benedikt; Aminian, Kamiar; Müller, Erich

2017-01-01

This study explored the use of body worn sensors to evaluate the vibrations that act on the human body in alpine ski racing from a general and a back overuse injury prevention perspective. In the course of a biomechanical field experiment, six male European Cup-level athletes each performed two runs on a typical giant slalom (GS) and slalom (SL) course, resulting in a total of 192 analyzed turns. Three-dimensional accelerations were measured by six inertial measurement units placed on the right and left shanks, right and left thighs, sacrum, and sternum. Based on these data, power spectral density (PSD; i.e., the signal's power distribution over frequency) was determined for all segments analyzed. Additionally, as a measure expressing the severity of vibration exposure, root-mean-square (RMS) acceleration acting on the lower back was calculated based on the inertial acceleration along the sacrum's longitudinal axis. In both GS and SL skiing, the PSD values of the vibrations acting at the shank were found to be largest for frequencies below 30 Hz. While being transmitted through the body, these vibrations were successively attenuated by the knee and hip joint. At the lower back (i.e., sacrum sensor), PSD values were especially pronounced for frequencies between 4 and 10 Hz, whereas a corresponding comparison between GS and SL revealed higher PSD values and larger RMS values for GS. Because vibrations in this particular range (i.e., 4 to 10 Hz) include the spine's resonant frequency and are known to increase the risk of structural deteriorations/abnormalities of the spine, they may be considered potential components of mechanisms leading to overuse injuries of the back in alpine ski racing. Accordingly, any measure to control and/or reduce such skiing-related vibrations to a minimum should be recognized and applied. In this connection, wearable sensor technologies might help to better monitor and manage the overall back overuse-relevant vibration exposure of athletes in regular training and or competition settings in the near future.

Sports injury and illness epidemiology: Great Britain Olympic Team (TeamGB) surveillance during the Sochi 2014 Winter Olympic Games.

PubMed

Palmer-Green, Debbie; Elliott, Niall

2015-01-01

Sports injury and illness surveillance is the first step in injury and illness prevention, and is important for the protection of both athlete health and performance in major competitions. To identify the prevalence, severity nature and causes of athlete injuries and illnesses in the Great Britain Olympic Team (TeamGB) during the Sochi 2014 Winter Olympic Games. The observational prospective cohort study followed the Great Britain Injury/Illness Performance Project surveillance methodology and obtained information on injuries and illnesses that occurred during the Games between 30 January and 23 February 2014 in TeamGB athletes (n=56). Among the 56 TeamGB athletes, there were 27 injuries and 11 illnesses during the Olympic Games period. This equated to 39% sustaining at least one injury and 18% at least one illness, with an incidence of 48.2 injuries and 19.6 illnesses per 100 athletes, respectively. Of all injuries and illnesses, 9% and 7%, respectively, resulted in time loss. The risk of sustaining an injury was highest for freestyle skiing, skeleton and snowboarding; and lowest for curling, biathlon and Alpine skiing (with no reported injuries); with the lower limb being the most commonly injured location. Respiratory system illnesses were most frequently reported overall, and older female athletes were the ones most affected by illness. The risk of injury was double the risk of illness for TeamGB athletes. Overall, the rate of time-loss issues was low. Methodological considerations are important when interpreting data, and prevention strategies should focus on those issues causing the greatest risk, in terms of prevalence and severity, to athlete health and performance. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

HSP-70 mitigates LPS/SKI-induced cell damage by increasing sphingosine kinase 1 (SK1).

PubMed

Ding, Xuan Z; Feng, Xiao R; Borschel, Richard H; Nikolich, Mikeljon P; Feng, Jie; Li, Yan S; Hoover, David L

2010-06-01

Heat shock proteins (HSPs) are potent protectors of cellular integrity against environmental stresses, including toxic microbial products. To investigate the mechanism of HSP-70 cell protection against bacterial lipopolysaccharide (LPS), we established a stable HSP-70 gene-transfected RAW 264.7 murine macrophage model of LPS-induced cell death. Bacterial LPS increases the activity of sphingosine kinase 1 (SK1), which catalyzes formation of sphingosine-1-phosphate (S1P). S1P functions as a critical signal for initiation and maintenance of diverse aspects of immune cell activation and function. When mouse macrophages were incubated with Escherichia coli LPS (1 microg/ml) and sphingosine kinase inhibitor (SKI, 5 microM), 90% of cells died. Neither LPS nor SKI alone at these doses damaged the cells. The LPS/SKI-induced cell death was partially reversed by overexpression of HSP-70 in gene-transfected macrophages. The specificity of HSP-70 in this reversal was demonstrated by transfection of HSP-70-specific siRNA. Down-regulation of HSP-70 expression after transfection of siRNA specific for HSP-70 was associated with increased LPS/SKI-induced cell damage. Overexpression of human or murine HSP-70 (HSPA1A and Hspa1a, respectively) increased both cellular SK1 mRNA and protein levels. Cellular heat shock also increased SK1 protein. These studies confirm the importance of SK1 as a protective moiety in LPS-induced cell injury and demonstrate that HSP-70-mediated protection from cells treated with LPS/SKI is accompanied by upregulating expression of SK1. HSP-70-mediated increases in SK1 and consequent increased levels of S1P may also play a role in protection of cells from other processes that lead to programmed cell death. Published by Elsevier Inc.

[Chiasma lesions in sport accidents (author's transl)].

PubMed

Fulmek, R

1975-09-01

With reference to a chiasma contusion, proved at autopsy, sustained by a football player after a temporal impression fracture due to contact of a knee with his skull, the pathological mechanism causing chiasma injuries in blunt head injuries is explained. Finally, from our own experience we report on 2 water-sports accidents sustained by young men (a jump from the trampoline, and a fall during water-skiing) where chiasma-lesions were diagnosed from typical field defects.

Helmets for skiers and snowboarders: an injury prevention program.

PubMed

Levy, A Stewart; Hawkes, Allison P; Rossie, George V

2007-07-01

The authors' Level I trauma center has advocated the use of ski helmets for several years and in 1998, undertook a social-marketing campaign and a helmet loaner program to increase helmet use among skiers and snowboarders. The loaner program's effect on helmet acceptance was measured by comparing helmet acceptance in participating rental stores with acceptance in nonparticipating stores during 3 years. For the 1998-1999 season, 13.8% of renters in the participating stores accepted a helmet compared to 1.38% in the nonparticipating stores (p < .01); for 2000-2001, 33.5% to 3.93% (p < .01); and for 2001-2002, 30.3% to 4.48% (p < .01). The authors believe that efforts to increase helmet use--by increasing education and public awareness and decreasing barriers, such as through helmet loaner programs or routinely including helmets in rental packages--have significant potential to decrease the incidence and severity of brain injuries from skiing and/or snowboarding accidents in Colorado.

Epidemiology of sport-related spinal cord injuries: A systematic review.

PubMed

Chan, Christie Wl; Eng, Janice J; Tator, Charles H; Krassioukov, Andrei

2016-05-01

Despite the recognition of sports as a significant contributor in the etiology of spinal cord injury (SCI), no studies have systematically explored the epidemiology of SCI caused by sports. This paper aims to give a systematic overview of the epidemiology of sport-related spinal cord injury around the world. A systematic review was conducted to identify published literature reporting the epidemiology of SCI caused by sports. The literature search was conducted in MEDLINE/PubMed, CINAHL, EMBASE, PsycINFO and Sportdiscus with date limits 1980 through to July 2015. Data from 54 studies covering 25 countries was extracted and collated. Important findings include identification of 6 countries in which sports accounts for over 13% of SCI (highest to lowest: Russia, Fiji, New Zealand, Iceland, France and Canada); individual sports with high risk for SCI (diving, skiing, rugby, and horseback riding); and the most common level of injury for various sports (almost entirely cervical for hockey, skiing, diving and American football, while over half of horseback riding and snowboarding injuries are thoracic or lumbosacral). This paper identifies countries and sports with higher rates of sport-related SCIs where implementation of prevention programs and reporting systems to track SCI epidemiology may be helpful, and highlights gaps in our current knowledge for further investigation. The comparison of SCI occurrence for each sport across countries, as well as examination of the specific characteristics of SCI incurred for individual sports will assist in directing efforts for prevention.

Epidemiology of sport-related spinal cord injuries: A systematic review

PubMed Central

Chan, Christie WL; Tator, Charles H.

2016-01-01

Context Despite the recognition of sports as a significant contributor in the etiology of spinal cord injury (SCI), no studies have systematically explored the epidemiology of SCI caused by sports. Objective This paper aims to give a systematic overview of the epidemiology of sport-related spinal cord injury around the world. Methods A systematic review was conducted to identify published literature reporting the epidemiology of SCI caused by sports. The literature search was conducted in MEDLINE/PubMed, CINAHL, EMBASE, PsycINFO and Sportdiscus with date limits 1980 through to July 2015. Data from 54 studies covering 25 countries was extracted and collated. Results Important findings include identification of 6 countries in which sports accounts for over 13% of SCI (highest to lowest: Russia, Fiji, New Zealand, Iceland, France and Canada); individual sports with high risk for SCI (diving, skiing, rugby, and horseback riding); and the most common level of injury for various sports (almost entirely cervical for hockey, skiing, diving and American football, while over half of horseback riding and snowboarding injuries are thoracic or lumbosacral). Conclusion This paper identifies countries and sports with higher rates of sport-related SCIs where implementation of prevention programs and reporting systems to track SCI epidemiology may be helpful, and highlights gaps in our current knowledge for further investigation. The comparison of SCI occurrence for each sport across countries, as well as examination of the specific characteristics of SCI incurred for individual sports will assist in directing efforts for prevention. PMID:26864974

Effect of ski simulator training on kinematic and muscle activation of the lower extremities

PubMed Central

Moon, Jeheon; Koo, Dohoon; Kim, Kitae; Shin, Insik; Kim, Hyeyoung; Kim, Jinhae

2015-01-01

[Purpose] This study aimed to verify the effectiveness of an augmented reality-based ski simulator through analyzing the changes in movement patterns as well as the engagement of major muscles of the lower body. [Subjects] Seven subjects participated in the study. All were national team-level athletes studying at “K” Sports University in Korea who exhibited comparable performance levels and had no record of injuries in the preceding 6 months (Age 23.4 ± 3.8 years; Height 172.6 ± 12.1 cm; Weight 72.3 ± 16.2 kg; Experience 12.3 ± 4.8 years). [Methods] A reality-based ski simulator developed by a Korean manufacturer was used for the study. Three digital video cameras and a wireless electromyography system were used to perform 3-dimensional motion analysis and measure muscle activation level. [Results] Left hip angulation was found to increase as the frequency of the turns increased. Electromyography data revealed that the activation level of the quadriceps group’s extension muscles and the biceps femoris group’s flexing muscles had a crossing pattern. [Conclusion] Sustained training using an augmented reality-based ski simulator resulted in movements that extended the lower body joints, which is thought to contribute to increasing muscle fatigue. PMID:26357449

Prescriptive Package. Improving Patrol Productivity. Volume I. Routine Patrol.

ERIC Educational Resources Information Center

Gay, William G.; Schack, Stephen

Designed to assist police departments in improving the productivity of their patrol operations, this volume on routine patrol and a companion volume on specialized patrol operations are intended for use by various sizes of departments. The volume on routine patrol focuses on the major issues of patrol productivity and recommends a number of…

Stretching & Flexibility: An Interactive Encyclopedia of Stretching. [CD-ROM].

ERIC Educational Resources Information Center

2002

This CD-ROM offers 140 different stretches in full-motion video sequences. It focuses on the proper techniques for overall physical fitness, injury prevention and rehabilitation, and 23 different sports (e.g., golf, running, soccer, skiing, climbing, football, and baseball). Topics include stretching for sports; stretching awareness and education…

Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration.

PubMed

Macias-Silva, Marina; Li, Wei; Leu, Julia I; Crissey, Mary Ann S; Taub, Rebecca

2002-08-09

Transforming growth factor-beta (TGF-beta) functions as an antiproliferative factor for hepatocytes. However, for unexplained reasons, hepatocytes become resistant to TGF-beta signals and can proliferate despite the presence of TGF-beta during liver regeneration. TGF-beta is up-regulated during liver regeneration, although it is not known whether it is active or latent. TGF-beta activity may be examined by assessing Smad activation, a downstream signaling pathway. Smad pathway activation during liver regeneration induced by partial hepatectomy or CC4 injury was examined by assessing the levels of phospho-Smad2 and Smad2-Smad4 complexes. We found that Smad proteins were slightly activated in quiescent liver, but that their activation was further enhanced in regenerating liver. Interestingly, TGF-beta/Smad pathway inhibitors (SnoN and Ski) were up-regulated during regeneration, and notably, SnoN was induced mainly in hepatocytes. SnoN and Ski are transcriptional repressors that may render some cells resistant to TGF-beta via binding Smad proteins. Complexes between SnoN, Ski, and the activated Smad proteins were detected from 2 to 120 h during the major proliferative phase in regenerating liver. Inhibitory complexes decreased after liver mass restitution (5-15 days), suggesting that persistently activated Smad proteins might participate in returning the liver to a quiescent state. Our data show that active TGF-beta/Smad signals are present during regeneration and suggest that SnoN/Ski induction might explain hepatocyte resistance to TGF-beta during the proliferative phase.

Determination of the centre of mass kinematics in alpine skiing using differential global navigation satellite systems.

PubMed

Gilgien, Matthias; Spörri, Jörg; Chardonnens, Julien; Kröll, Josef; Limpach, Philippe; Müller, Erich

2015-01-01

In the sport of alpine skiing, knowledge about the centre of mass (CoM) kinematics (i.e. position, velocity and acceleration) is essential to better understand both performance and injury. This study proposes a global navigation satellite system (GNSS)-based method to measure CoM kinematics without restriction of capture volume and with reasonable set-up and processing requirements. It combines the GNSS antenna position, terrain data and the accelerations acting on the skier in order to approximate the CoM location, velocity and acceleration. The validity of the method was assessed against a reference system (video-based 3D kinematics) over 12 turn cycles on a giant slalom skiing course. The mean (± s) position, velocity and acceleration differences between the CoM obtained from the GNSS and the reference system were 9 ± 12 cm, 0.08 ± 0.19 m · s(-1) and 0.22 ± 1.28 m · s(-2), respectively. The velocity and acceleration differences obtained were smaller than typical differences between the measures of several skiers on the same course observed in the literature, while the position differences were slightly larger than its discriminative meaningful change. The proposed method can therefore be interpreted to be technically valid and adequate for a variety of biomechanical research questions in the field of alpine skiing with certain limitations regarding position.

Biomechanical factors influencing the performance of elite Alpine ski racers.

PubMed

Hébert-Losier, Kim; Supej, Matej; Holmberg, Hans-Christer

2014-04-01

Alpine ski racing is a popular international winter sport that is complex and challenging from physical, technical, and tactical perspectives. Despite the vast amount of scientific literature focusing on this sport, including topical reviews on physiology, ski-snow friction, and injuries, no review has yet addressed the biomechanics of elite alpine ski racers and which factors influence performance. In World Cup events, winning margins are often mere fractions of a second and biomechanics may well be a determining factor in podium place finishes. The aim of this paper was to systematically review the scientific literature to identify the biomechanical factors that influence the performance of elite alpine ski racers, with an emphasis on slalom, giant slalom, super-G, and downhill events. Four electronic databases were searched using relevant medical subject headings and key words, with an additional manual search of reference lists, relevant journals, and key authors in the field. Articles were included if they addressed human biomechanics, elite alpine skiing, and performance. Only original research articles published in peer-reviewed journals and in the English language were reviewed. Articles that focused on skiing disciplines other than the four of primary interest were excluded (e.g., mogul, ski-cross and freestyle skiing). The articles subsequently included for review were quality assessed using a modified version of a validated quality assessment checklist. Data on the study population, design, location, and findings relating biomechanics to performance in alpine ski racers were extracted from each article using a standard data extraction form. A total of 12 articles met the inclusion criteria, were reviewed, and scored an average of 69 ± 13% (range 40-89%) upon quality assessment. Five of the studies focused on giant slalom, four on slalom, and three on downhill disciplines, although these latter three articles were also relevant to super-G events. Investigations on speed skiing (i.e., downhill and super-G) primarily examined the effect of aerodynamic drag on performance, whereas the others examined turn characteristics, energetic principles, technical and tactical skills, and individual traits of high-performing skiers. The range of biomechanical factors reported to influence performance included energy dissipation and conservation, aerodynamic drag and frictional forces, ground reaction force, turn radius, and trajectory of the skis and/or centre of mass. The biomechanical differences between turn techniques, inter-dependency of turns, and abilities of individuals were also identified as influential factors in skiing performance. In the case of slalom and giant slalom events, performance could be enhanced by steering the skis in such a manner to reduce the ski-snow friction and thereby energy dissipated. This was accomplished by earlier initiation of turns, longer path length and trajectory, earlier and smoother application of ground reaction forces, and carving (rather than skidding). During speed skiing, minimizing the exposed frontal area and positioning the arms close to the body were shown to reduce the energy loss due to aerodynamic drag and thereby decrease run times. In actual races, a consistently good performance (i.e., fast time) on different sections of the course, terrains, and snow conditions was a characteristic feature of winners during technical events because these skiers could maximize gains from their individual strengths and minimize losses from their respective weaknesses. Most of the articles reviewed were limited to investigating a relatively small sample size, which is a usual limitation in research on elite athletes. Of further concern was the low number of females studied, representing less than 4% of all the subjects examined in the articles reviewed. In addition, although overall run time is the ultimate measure of performance in alpine ski racing, several other measures of instantaneous performance were also employed to compare skiers, including the aerodynamic drag coefficient, velocity, section time, time lost per change in elevation, and mechanical energy behaviours, which makes cross-study inferences problematic. Moreover, most studies examined performance through a limited number of gates (i.e., 2-4 gates), presumably because the most commonly used measurement systems can only capture small volumes on a ski field with a reasonable accuracy for positional data. Whether the biomechanical measures defining high instantaneous performance can be maintained throughout an entire race course remains to be determined for both male and female skiers. Effective alpine skiing performance involves the efficient use of potential energy, the ability to minimize ski-snow friction and aerodynamic drag, maintain high velocities, and choose the optimal trajectory. Individual tactics and techniques should also be considered in both training and competition. To achieve better run times, consistency in performance across numerous sections and varied terrains should be emphasized over excellence in individual sections and specific conditions.

Substantial injuries influence ranking position in young elite athletes of athletics, cross-country skiing and orienteering.

PubMed

von Rosen, P; Heijne, A

2018-04-01

The relationship between injury and performance in young athletes is scarcely studied. The aim of this study was therefore to explore the association between injury prevalence and ranking position among adolescent elite athletes. One hundred and sixty-two male and female adolescent elite athletes (age range 15-19), competing in athletics (n = 59), cross-country skiing (n = 66), and orienteering (n = 37), were monitored weekly over 22-47 weeks using a web-based injury questionnaire. Ranking lists were collected. A significant (P = .003) difference was found in the seasonal substantial injury prevalence across the ranked athletes over the season, where the top-ranked (median 3.6%, 25-75th percentiles 0%-14.3%) and middle-ranked athletes (median 2.3%, 25-75th percentiles 0%-10.0%) had a lower substantial injury prevalence compared to the low-ranked athletes (median 11.3%, 25-75th percentiles 2.5%-27.1%), during both preseason (P = .002) and competitive season (P = .031). Athletes who improved their ranking position (51%, n = 51) reported a lower substantial injury prevalence (median 0%, 25-75th percentiles 0%-10.0%) compared to those who decreased (49%, n = 49) their ranking position (md 6.7%, 25-75th percentiles 0%-22.5%). In the top-ranked group, no athlete reported substantial injury more than 40% of all data collection time points compared to 9.6% (n = 5) in the middle-ranked, and 17.3% (n = 9) in the low-ranked group. Our results provide supporting evidence that substantial injuries, such as acute and overuse injuries leading to moderate or severe reductions in training or sports performance, influence ranking position in adolescent elite athletes. The findings are crucial to stakeholders involved in adolescent elite sports and support the value of designing effective preventive interventions for substantial injuries. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

How safe is adventure tourism in New Zealand? An exploratory analysis.

PubMed

Bentley, T; Page, S; Meyer, D; Chalmers, D; Laird, I

2001-08-01

The paper reports findings from a multidisciplinary programme of research, the major aims of which were to determine the nature and extent of the New Zealand adventure tourism injury problem. Analysis of hospital discharge and mortality data for a 15-year period identified adventure tourism-related activities as contributing to approximately 20% of overseas visitor injuries, and 22% of fatalities. Activities that commonly involve independent-unguided adventure tourism, notably mountaineering, skiing and tramping, contributed most to injury and fatality incidence. Horse riding and cycling activities were identified from hospital discharge data and adventure tourism operators' reported client injury-incidence, as the commercial adventure tourism activities most frequently involved in client injuries. Falls were the most common injury events, and a range of client, equipment, environmental and organisational risk factors were identified. Possible interventions to reduce injury risk among overseas and domestic adventure tourists are discussed.

Non-minor injuries among children sustained in an outdoor environment--a retrospective register study.

PubMed

Gyllencreutz, Lina; Rolfsman, Ewa; Saveman, Britt-Inger

2015-01-01

The aim was to investigate non-minor injuries sustained during outdoor activities among 0-12 year old children and to explore self-reported circumstances surrounding these incidents. During 2007-2009, the Umeå University Hospital injury database (IDB) registered 795 children with moderate (n = 778) and serious (n = 17) injuries, such as fractures. The IDB includes data from a questionnaire completed in the emergency department by the injured child or a parent. The open-ended questions catch the injured child's description of what circumstances precede the injury incident. The most commonly reported activities contributing to injuries were play, sport, and transport. Surface impacts were also reported as contributing factors along with products such as trampolines, bicycles, and downhill skis. By achieving a deeper knowledge about the activities and circumstances that precede non-minor injury incidents, creating safer outdoor environments may be feasible.

The incidence of inflatable rescue boat injuries in Queensland surf lifesavers.

PubMed

Bigby, K J; McClure, R J; Green, A C

2000-05-15

To estimate the current incidence of serious injuries in Queensland surf lifesavers related to inflatable rescue boat (IRB) use, and to describe the nature of the injuries. Descriptive study. The 3050 members of Queensland's 57 surf life saving clubs who drove or crewed an IRB in Queensland between July 1997 and June 1998. Incidence of serious IRB-related injuries that resulted in claims for workers compensation in 1997-1998, and type and anatomical location of injury. Thirty-six IRB-related injuries were lodged with WorkCover Queensland by surf lifesavers during 1997-1998, giving an estimated crude incidence of 1.2%. Sixty-one per cent of injuries affected the right side of the body; two-thirds of these involved the knee, leg and ankle. IRB injuries occurred most often during patrol duty (39% of cases) and it was usually the crewperson (86% of cases) who was injured. Fracture and fracture-dislocations constituted a third of the injuries, with 75% occurring in the right leg and ankle. Despite the known incomplete reporting of these injuries, our findings suggest that IRB-related injury caused substantial morbidity among volunteer surf lifesavers. The pattern of injuries suggests biomechanically preventable causes.

[François Girardot (1773-1831) the surgeon of Light - Cavalrymen Regiment of Napoleon I Guard].

PubMed

Witczak, W

1996-01-01

The paper is the first wider biographic study presentif life and activity of François Girardot (1773-1831), a French physician, a surgeon of Polish light-cavalrymen regiment of Napoleon I guard for many years; since 1816 permanently domiciled in the Congress Kingdom of Poland, in Warsaw and Opinogóra, as a family doctor of Krasińskis family. There are his relations with Poland recalled, started in 1798 already, there are shown some famous patients of Girardot - Klementyna Hoffman of Tańskis, Zygmunt Krasiński and Fryderyk Chopin. There is also the attention drawn to his medical activity among poor population of Warsaw. The fact is underlined, that Girardot as the only physician was made by Napoleon the baron of Empire at the battle field (Craonne, 7th March, 1814), directly after injury, the effect of which there was an amputation of leg. It is also indicated, that despite unquestionable military merits, confirmed by numerous awards and the title of baron granted, and also medical merits of Girardot, he is still remaining a personage not well known to the historians of Napoleonic period.

Research on application of GIS and GPS in inspection and management of city gas pipeline network

NASA Astrophysics Data System (ADS)

Zhou, Jin; Meng, Xiangyin; Tao, Tao; Zhang, Fengpei

2018-01-01

To solve the problems existing in the current Gas Company patrol management, such as inaccurate attendance, whether or not the patrol personnel exceed the scope of patrol inspection. This paper Proposed that we apply the SuperMap iDeskTop 8C plug-in desktop GIS application and development platform, the positioning function of GPS and the data transmission function of 3G/4G/GPRS/Ethernet to develop a gas pipeline inspection management system. We build association between real-time data, pipe network information, patrol data, map information, spatial data and so on to realize the bottom data fusion, use the mobile location system and patrol management client to achieve real-time interaction between the client and the mobile terminal. Practical application shows that the system has completed the standardized management of patrol tasks, the reasonable evaluation of patrol work and the maximum utilization of patrol resources.

[Factors affecting the pressure distribution underneath the foot sole in ski boots].

PubMed

Schaff, P; Kulot, M; Hauser, W; Rosemeyer, B

1988-12-01

The determination of pressure patterns underneath the footsole inside skiboots, may reveal reasons for footpain and injury risk. In our study, a new developed 72 point measuring mat was used in 5 different skiboots. Data were collected in 10 subjects in different forward flexion positions. In addition a determination of the pressure distribution over the instep was done by means of single measuring points. The results proof, that a proper adapting along the dorsum of the foot does lower the forefoot load during flexion. A tightly closed and well adapted boot will lead to a significant reduction of the total load on the footsole. High shaft models show similar pressure patterns even at earlier forward flexion angles. A pressure related discrimination between rear entry and traditional boots, that was found along the tibia, was not the case underneath the footsole. The force transmission is mainly performed along the shaft of the boot. The effect of orthotics designed mainly to support steerability of the ski, is therefore doubtful. The results may help to improve our knowledge of the interaction between boot and skier and lead, together with future field research, to a reduction of equipment related injuries.

Jules and Augusta Dejerine, Pierre Marie, Joseph Babiński, Georges Guillain and their students during World War I.

PubMed

Walusinski, O

2017-03-01

World War I (1914-1918), however tragic, was nonetheless an "edifying school of nervous system experimental pathology" not only because of the various types of injuries, but also because their numbers were greater than any physician could have foreseen. The peripheral nervous system, the spine and the brain were all to benefit from the subsequent advances in clinical and anatomo-functional knowledge. Neurosurgeons took on nerve sutures, spinal injury exploration, and the localization and extraction of intracranial foreign bodies. Little by little, physical medicine and rehabilitation were established. A few of the most famous Parisian neurologists at the time-Jules and Augusta Dejerine, Pierre Marie, Joseph Babiński and Georges Guillain, who directed the military neurology centers-took up the physically and emotionally exhausting challenge of treating thousands of wounded soldiers. They not only cared for them, but also studied them scientifically, with the help of a small but devoted band of colleagues. The examples presented here reveal their courage and their efforts to make discoveries for which we remain grateful today. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Retrospective case evaluation of gender differences in sports injuries in a Japanese sports medicine clinic.

PubMed

Iwamoto, Jun; Takeda, Tsuyoshi; Sato, Yoshihiro; Matsumoto, Hideo

2008-12-01

Although both gender- and sports-specific injuries exist among athletes, gender differences in the types of injuries caused by sports activities, except for anterior cruciate ligament (ACL) injury and anterior knee pain, are not well established. An observational study with a retrospective case-series design was conducted to investigate gender-specific differences in the types of injuries sustained while engaging in sports activities common to both males and females. We analyzed injuries sustained during sports activities including basketball, volleyball, tennis, skiing, track and field, and swimming, using data on age, sex, sports activities, activity levels, and sports injuries that had been computerized at our sports medicine (orthopedics) clinic. Inclusion criteria were sports activities that had a record of >100 injuries in total and athletes aged <50 years who were engaging in only 1 sports activity. We determined the absolute number of patients in each category and their percentage (proportion) of our cohort. The proportions of common injuries caused by sports activities were investigated, and gender-specific differences in the types of common injuries caused by sports activities were clarified. The Fisher exact test was used to determine the significance (P < 0.01) of the gender-specific differences in the types of sports injuries. According to our database, during the 14-year period between October 1992 and December 2006, a total of 2,989 athletes (1,624 males and 1,365 females) aged <50 years who engaged in 1 of the 6 sports activities described consulted our sports medicine clinic. The most common sports injuries were ACL injury (14.3%) and knee pain (13.7%), followed by ankle sprain (9.4%), lumbar disc disease (7.0%), meniscus injury (5.1%), stress fracture (2.9%), low back pain (2.5%), patellar tendinitis (2.1%), injury of the medial collateral ligament of the knee (2.0%), lumbar spondylolysis (1.7%), and muscle strain (1.5%). Among these 11 types of sports injuries, a significantly higher proportion of females who engaged in basketball (24.4% vs 10.5%), volleyball (20.5% vs 4.5%), or skiing (41.4% vs 26.5%) presented with an ACL injury, compared with their male counterparts (all, P < 0.001). There was also a significantly higher proportion of females than of males among the track and field athletes who presented with stress fractures (18.7% vs 3.9%; P < 0.001). The findings of this retrospective study suggest that there are gender-specific differences in the types of injuries sustained during sports activities.

An evaluation of the benefits of the Alabama service and assistance patrol : final report.

DOT National Transportation Integrated Search

2009-12-01

The Alabama Service and Assistance Patrol (A.S.A.P.) is a freeway service patrol operated by : the Alabama Department of Transportation (ALDOT) in the Birmingham region of Alabama. : This patrol of service vehicles travels continuously on approximate...

46 CFR 78.47-23 - Supervised patrol stations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 3 2012-10-01 2012-10-01 false Supervised patrol stations. 78.47-23 Section 78.47-23... Fire and Emergency Equipment, Etc. § 78.47-23 Supervised patrol stations. (a) Each supervised patrol clock or key station shall be numbered. (b) [Reserved] ...

46 CFR 78.47-23 - Supervised patrol stations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 3 2011-10-01 2011-10-01 false Supervised patrol stations. 78.47-23 Section 78.47-23... Fire and Emergency Equipment, Etc. § 78.47-23 Supervised patrol stations. (a) Each supervised patrol clock or key station shall be numbered. (b) [Reserved] ...

46 CFR 78.47-23 - Supervised patrol stations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Supervised patrol stations. 78.47-23 Section 78.47-23... Fire and Emergency Equipment, Etc. § 78.47-23 Supervised patrol stations. (a) Each supervised patrol clock or key station shall be numbered. (b) [Reserved] ...

Optimal Patrol to Detect Attacks at Dispersed Heterogeneous Locations

DTIC Science & Technology

2013-12-01

path with one revisit SPR2 Shortest path with two revisits SPR3 Shortest path with three revisits TSP Traveling salesman problem UAV Unmanned aerial...path patrol pattern. Finding the shortest-path patrol pattern is an example of solving a traveling salesman problem , as described in Section 16.5 of...use of patrol paths based on the traveling salesman prob- lem (TSP), where patrollers follow the shortest Hamiltonian cycle in a graph in order to

Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yi; Pirisi, Lucia; Creek, Kim E., E-mail: creekk@sccp.sc.edu

2013-09-15

We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in HKc/HPV16 and even further in HKc/DR, compared to HKc. TGF-β treatment of HKc, HKc/HPV16, and HKc/DR dramatically decreased Ski. TGF-β-induced Ski degradation was delayed in HKc/DR. Ski and phospho-Ski protein levels are cell cycle dependent with maximal Ski expression and localization to centrosomes and mitotic spindles during G2/M. ShRNA knock down of Ski in HKc/DR inhibited cellmore » proliferation. More intense nuclear and cytoplasmic Ski staining and altered Ski localization were found in cervical cancer samples compared to adjacent normal tissue in a cervical cancer tissue array. Overall, these studies demonstrate altered Ski protein levels, degradation and localization in HPV16-transformed human keratinocytes and in cervical cancer. - Highlights: • Ski oncoprotein levels increase during progression of HPV16-transformed cells. • Ski and phospho-Ski protein levels are cell cycle dependent. • Ski knock-down in HPV16-transformed keratinocytes inhibited cell proliferation. • Cervical cancer samples overexpress Ski.« less

Ski jumping takeoff in a wind tunnel with skis.

PubMed

Virmavirta, Mikko; Kivekäs, Juha; Komi, Paavo

2011-11-01

The effect of skis on the force-time characteristics of the simulated ski jumping takeoff was examined in a wind tunnel. Takeoff forces were recorded with a force plate installed under the tunnel floor. Signals from the front and rear parts of the force plate were collected separately to examine the anteroposterior balance of the jumpers during the takeoff. Two ski jumpers performed simulated takeoffs, first without skis in nonwind conditions and in various wind conditions. Thereafter, the same experiments were repeated with skis. The jumpers were able to perform very natural takeoff actions (similar to the actual takeoff) with skis in wind tunnel. According to the subjective feeling of the jumpers, the simulated ski jumping takeoff with skis was even easier to perform than the earlier trials without skis. Skis did not much influence the force levels produced during the takeoff but they still changed the force distribution under the feet. Contribution of the forces produced under the rear part of the feet was emphasized probably because the strong dorsiflexion is needed for lifting the skis to the proper flight position. The results presented in this experiment emphasize that research on ski jumping takeoff can be advanced by using wind tunnels.

Suppression of p53 Activity through the Cooperative Action of Ski and Histone Deacetylase SIRT1*

PubMed Central

Inoue, Yasumichi; Iemura, Shun-ichiro; Natsume, Tohru; Miyazawa, Keiji; Imamura, Takeshi

2011-01-01

Ski was originally identified as an oncogene based on the fact that Ski overexpression transformed chicken and quail embryo fibroblasts. Consistent with these proposed oncogenic roles, Ski is overexpressed in various human tumors. However, whether and how Ski functions in mammalian tumorigenesis has not been fully investigated. Here, we show that Ski interacts with p53 and attenuates the biological functions of p53. Ski overexpression attenuated p53-dependent transactivation, whereas Ski knockdown enhanced the transcriptional activity of p53. Interestingly, Ski bound to the histone deacetylase SIRT1 and stabilized p53-SIRT1 interaction to promote p53 deacetylation, which subsequently decreased the DNA binding activity of p53. Consistent with the ability of Ski to inactivate p53, overexpressing Ski desensitized cells to genotoxic drugs and Nutlin-3, a small-molecule antagonist of Mdm2 that stabilizes p53 and activates the p53 pathway, whereas knocking down Ski increased the cellular sensitivity to these agents. These results indicate that Ski negatively regulates p53 and suggest that the p53-Ski-SIRT1 axis is an attractive target for cancer therapy. PMID:21149449

Design of Ski Boots for Alpine Ski Racing Based on Leg Frame of the Skier

NASA Astrophysics Data System (ADS)

Suzuki, Soichiro; Hayashi, Sueyoshi

A ski boot is important to make progress in ski turning technique as an interface between a skier and a ski. Especially in alpine ski races, suitability of design of the boots for racers becomes more important to achieve accurate and quick lean of the leg in ski turns. This study is aimed at building a new design concept of a ski boot that can improve the results of alpine ski races. In this paper, new design of an upper shell of a ski boot that was adjusted to the features of the frame of alpine ski racers was experimentally examined. As a result, it was demonstrated that a front and a rear part of the upper shell of a ski boot should be separately adjusted to the length of a shank of each player for well-balanced quick lean of the leg in the ski turn. Finally, the effect of new design of an upper shell was examined in giant slalom and slalom tests by Japanese alpine ski racers of the first rank. Consequently, the results showed that lean angle during turns was increased and finish time was shortened when the skiers wore the newly designed boots.

Forest Service patrol captain and patrol commanders report: nationwide study

Treesearch

Deborah J. Chavez; Joanne F. Tynon

2007-01-01

This is the third in a series of studies to evaluate perceptions of USDA Forest Service law enforcement personnel of the roles, responsibilities, and issues entailed in their jobs. An e-mail survey was administered to the 79 Forest Service patrol captains and patrol commanders (PCs) across the United States. Seventy completed and returned the questionnaire....

Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1

PubMed Central

Feld, Christine; Sahu, Peeyush; Frech, Miriam; Finkernagel, Florian; Nist, Andrea; Stiewe, Thorsten; Bauer, Uta-Maria; Neubauer, Andreas

2018-01-01

Abstract SKI is a transcriptional co-regulator and overexpressed in various human tumors, for example in acute myeloid leukemia (AML). SKI contributes to the origin and maintenance of the leukemic phenotype. Here, we use ChIP-seq and RNA-seq analysis to identify the epigenetic alterations induced by SKI overexpression in AML cells. We show that approximately two thirds of differentially expressed genes are up-regulated upon SKI deletion, of which >40% harbor SKI binding sites in their proximity, primarily in enhancer regions. Gene ontology analysis reveals that many of the differentially expressed genes are annotated to hematopoietic cell differentiation and inflammatory response, corroborating our finding that SKI contributes to a myeloid differentiation block in HL60 cells. We find that SKI peaks are enriched for RUNX1 consensus motifs, particularly in up-regulated SKI targets upon SKI deletion. RUNX1 ChIP-seq displays that nearly 70% of RUNX1 binding sites overlap with SKI peaks, mainly at enhancer regions. SKI and RUNX1 occupy the same genomic sites and cooperate in gene silencing. Our work demonstrates for the first time the predominant co-repressive function of SKI in AML cells on a genome-wide scale and uncovers the transcription factor RUNX1 as an important mediator of SKI-dependent transcriptional repression. PMID:29471413

Peculiarities of Professional Training of the Us Border Patrol Special Operations Group's Agents

ERIC Educational Resources Information Center

Bloshchynskyi, Ihor

2017-01-01

Professional training of the agents of the US Border Patrol Special Operations Groups has been substantiated in the article. Special attention has been paid to revealing Selection and Training Course (STC) of the Border Patrol Tactical Unit (BORTAC) and the Border Patrol Search, Trauma, and Rescue Unit (BORSTAR). It has been determined that BORTAC…

Reconstruction of head impacts in FIS World Cup alpine skiing.

PubMed

Steenstrup, Sophie Elspeth; Mok, Kam-Ming; McIntosh, Andrew S; Bahr, Roald; Krosshaug, Tron

2018-06-01

Prior to the 2013/2014 season, the International Ski Federation (FIS) increased the helmet testing speed from 5.4 to 6.8 m/s for alpine downhill, super-G and giant slalom. Whether this increased testing speed reflects head impact velocities in real head injury situations on snow is unclear. We therefore investigated the injury mechanisms and gross head impact biomechanics in seven real head injury situations among World Cup (WC) alpine skiers. We analysed nine head impacts from seven head injury videos from the FIS Injury Surveillance System, throughout nine WC seasons (2006-2015) in detail. We used commercial video-based motion analysis software to estimate head impact kinematics in two dimensions, including directly preimpact and postimpact, from broadcast video. The sagittal plane angular movement of the head was also measured using angle measurement software. In seven of nine head impacts, the estimated normal to slope preimpact velocity was higher than the current FIS helmet rule of 6.8 m/s (mean 8.1 (±SD 0.6) m/s, range 1.9±0.8 to 12.1±0.4 m/s). The nine head impacts had a mean normal to slope velocity change of 9.3±1.0 m/s, range 5.2±1.1 to 13.5±1.3 m/s. There was a large change in sagittal plane angular velocity (mean 43.3±2.9 rad/s (range 21.2±1.5 to 64.2±3.0 rad/s)) during impact. The estimated normal to slope preimpact velocity was higher than the current FIS helmet rule of 6.8 m/s in seven of nine head impacts. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer

PubMed Central

Chen, Yi; Pirisi, Lucia; Creek, Kim E.

2013-01-01

We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in HKc/HPV16 and even further in HKc/DR, compared to HKc. TGF-β treatment of HKc, HKc/HPV16, and HKc/DR dramatically decreased Ski. TGF-β-induced Ski degradation was delayed in HKc/DR. Ski and phospho-Ski protein levels are cell cycle dependent with maximal Ski expression and localization to centrosomes and mitotic spindles during G2/M. ShRNA knock down of Ski in HKc/DR inhibited cell proliferation. More intense nuclear and cytoplasmic Ski staining and altered Ski localization were found in cervical cancer samples compared to adjacent normal tissue in a cervical cancer tissue array. Overall, these studies demonstrate altered Ski protein levels, degradation and localization in HPV16-transformed human keratinocytes and in cervical cancer. PMID:23809940

Identification of Ski as a target for Aurora A kinase

PubMed Central

Mosquera, Jocelyn; Armisen, Ricardo; Zhao, Hong Ling; Rojas, Diego A.; Maldonado, Edio; Tapia, Julio C; Colombo, Alicia; Hayman, Michael J; Marcelain, Katherine

2011-01-01

Ski is a negative regulator of the transforming growth factor-β and other signalling pathways. The absence of SKI in mouse fibroblasts leads to chromosome segregation defects and genomic instability, suggesting a role for Ski during mitosis. At this stage, Ski is phosphorylated but to date little is known about the kinases involved in this process. Here, we show that Aurora A kinase is able to phosphorylate Ski in vitro. In vivo, Aurora A and Ski co-localized at the centrosomes and co-immunoprecipitated. Conversely, a C-terminal truncation mutant of Ski (SkiΔ491–728) lacking a coiled-coil domain, displayed decreased centrosomal localization. This mutant no longer co-immunoprecipitated with Aurora-A in vivo, but was still phosphorylated in vitro, indicating that the Ski-Aurora A interaction takes place at the centrosomes. These data identify Ski as a novel target of Aurora A and contribute to an understanding of the role of these proteins in the mitotic process. PMID:21600873

Epidemiology of Snow Skiing- Versus Snowboarding-Related Concussions Presenting to the Emergency Department in the United States from 2010 to 2014.

PubMed

Gil, Joseph A; DeFroda, Steven F; Kriz, Peter; Owens, Brett D

2017-09-01

To examine the trend of concussions in skiers and snowboarders from 2010 to 2014; and to quantify and compare the incidence of concussions injuries in skiers and snowboarders who presented to emergency departments in the United States in 2014. Cross-sectional study of concussions in skiers and snowboarders who were evaluated in emergency departments in the United States. Incidence of concussions. The trend of the annual incidence of concussions for skiers and snowboarders remained stable from 2010 to 2014. An estimated total of 5388 skiing-related concussions and 5558 snowboarding-related concussions presented to emergency departments in the United States between January 1st, 2014, and December 31st, 2014. This represented an incidence of 16.9 concussions per 1 000 000 person-years for skiers and 17.4 concussions per 1 000 000 person-years for snowboarders. The incidence of concussions in the pediatric and young adult population of skiers was significantly higher than the incidence in the adult population. Similarly, the incidence of concussions in the pediatric and young adult population of snowboarders was significantly higher than the incidence in the adult population. The incidence of concussions was significantly higher in males compared with females in both skiing and snowboarding. The incidence of concussions from 2010 to 2014 plateaued in both skiers and snowboarders. Pediatric and young adult skiers and snowboarders had significantly higher incidences of concussion than the adult population. In contrast to the higher incidence of concussions in females in several sports including ice hockey, soccer, and basketball, the incidence of concussions was higher in males compared with females in both skiing and snowboarding.

Effects of North Carolina's mandatory safety belt law on children.

PubMed Central

Margolis, L. H.; Bracken, J.; Stewart, J. R.

1996-01-01

OBJECTIVES: To assess the effect of the North Carolina law mandating that all front seat passengers use a safety belt on children 4 through 15 years of age. METHODS: North Carolina collision reports, completed by local police or the state highway patrol for crashes with greater than $500 worth of damage, were analyzed using time series analysis on the monthly percentage of deaths and serious injuries between January of 1980 and February of 1994. RESULTS: Following the 1985 implementation of the law, children 4 to 15 years of age experienced a 42% decline in deaths and serious injuries. CONCLUSIONS: The mandatory safety belt law in North Carolina has been associated with a decline in deaths and serious injuries. Additional research in needed to assess the seat belt behaviors of this age group as well as the specific effects of seat belt use using outcome measures more precise than those available in police crash reports. PMID:9346051

The influence of grip on oxygen consumption and leg forces when using classical style roller skis.

PubMed

Ainegren, M; Carlsson, P; Laaksonen, M S; Tinnsten, M

2014-04-01

The purpose of this study was to investigate the influence of classical style roller skis' grip (static friction coefficients, μS) on cross-country skiers' oxygen consumption and leg forces during treadmill roller skiing, when using the diagonal stride and kick double poling techniques. The study used ratcheted wheel roller skis from the open market and a uniquely designed roller ski with an adjustable camber and grip function. The results showed significantly (P ≤ 0.05) higher oxygen consumption (∼ 14%), heart rate (∼ 7%), and lower propulsive forces from the legs during submaximal exercise and a shorter time to exhaustion (∼ 30%) in incremental maximal tests when using roller skis with a μS similar to on-snow skiing, while there was no difference between tests when using different pairs of roller skis with a similar, higher μS. Thus, we concluded that oxygen consumption (skiing economy), propulsive leg forces, and performance time are highly changed for the worse when using roller skis with a lower μS, such as for on-snow skiing with grip-waxed cross-country skis, in comparison to ratcheted wheel roller skis with several times higher μS. © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A Coupled Snow Operations-Skier Demand Model for the Ontario (Canada) Ski Region

NASA Astrophysics Data System (ADS)

Pons, Marc; Scott, Daniel; Steiger, Robert; Rutty, Michelle; Johnson, Peter; Vilella, Marc

2016-04-01

The multi-billion dollar global ski industry is one of the tourism subsectors most directly impacted by climate variability and change. In the decades ahead, the scholarly literature consistently projects decreased reliability of natural snow cover, shortened and more variable ski seasons, as well as increased reliance on snowmaking with associated increases in operational costs. In order to develop the coupled snow, ski operations and demand model for the Ontario ski region (which represents approximately 18% of Canada's ski market), the research utilized multiple methods, including: a in situ survey of over 2400 skiers, daily operations data from ski resorts over the last 10 years, climate station data (1981-2013), climate change scenario ensemble (AR5 - RCP 8.5), an updated SkiSim model (building on Scott et al. 2003; Steiger 2010), and an agent-based model (building on Pons et al. 2014). Daily snow and ski operations for all ski areas in southern Ontario were modeled with the updated SkiSim model, which utilized current differential snowmaking capacity of individual resorts, as determined from daily ski area operations data. Snowmaking capacities and decision rules were informed by interviews with ski area managers and daily operations data. Model outputs were validated with local climate station and ski operations data. The coupled SkiSim-ABM model was run with historical weather data for seasons representative of an average winter for the 1981-2010 period, as well as an anomalously cold winter (2012-13) and the record warm winter in the region (2011-12). The impact on total skier visits and revenues, and the geographic and temporal distribution of skier visits were compared. The implications of further climate adaptation (i.e., improving the snowmaking capacity of all ski areas to the level of leading resorts in the region) were also explored. This research advances system modelling, especially improving the integration of snow and ski operations models with demand and socioeconomic implications. This innovative integrated systems model approach can be exported to other major ski tourism markets (e.g., Canada, USA, Western and Eastern Europe, Australia, Japan) to facilitate global comparative assessments of ski tourism vulnerability to climate change, establishing the standard for ski tourism vulnerability assessments and advancing scholarly work on sustainable tourism and climate-compatible development in mountain communities.

Changes in the Balance Performance of Polish Recreational Skiers after Seven Days of Alpine Skiing

PubMed Central

Wojtyczek, Beata; Pasławska, Małgorzata; Raschner, Christian

2014-01-01

Alpine skiing is one of the most popular leisure time winter sporting activities. Skiing imposes high requirements concerning physical fitness, particularly regarding balance abilities. The main objective of this study was to evaluate the changes in balance performance of recreational skiers after a seven-day ski camp. A total of 78 students - 24 women and 54 men - participated in the study. The ski course was held in accordance with the official program of the Polish Ski Federation. The study sample was comprised of 43 beginners and 35 intermediate skiers. All students were tested with the MFT S3-Check, the day before and the day after the ski camp. The test system consisted of an unstable uniaxial platform, with an integrated sensor and corresponding software. Changes in balance performance (sensory and stability index) were evaluated using paired t-tests. Additionally, changes in sensory and stability categories, which were based on the norm data, were analyzed. Female and male participants showed significantly better sensory and stability indices after skiing. Considerable changes from weak or very weak to average or good balance categories could be seen after skiing for both sexes. Regarding skiing experience, both beginners and intermediate skiers improved their sensory and stability indices significantly after skiing. Hence, recreational alpine skiing resulted in better balance performance regardless of sex or skiing experience. Skiing as an outdoor activity offers the opportunity to improve balance performance with a positive impact on everyday life activities. PMID:25713663

Changes in the balance performance of polish recreational skiers after seven days of alpine skiing.

PubMed

Wojtyczek, Beata; Pasławska, Małgorzata; Raschner, Christian

2014-12-09

Alpine skiing is one of the most popular leisure time winter sporting activities. Skiing imposes high requirements concerning physical fitness, particularly regarding balance abilities. The main objective of this study was to evaluate the changes in balance performance of recreational skiers after a seven-day ski camp. A total of 78 students - 24 women and 54 men - participated in the study. The ski course was held in accordance with the official program of the Polish Ski Federation. The study sample was comprised of 43 beginners and 35 intermediate skiers. All students were tested with the MFT S3-Check, the day before and the day after the ski camp. The test system consisted of an unstable uniaxial platform, with an integrated sensor and corresponding software. Changes in balance performance (sensory and stability index) were evaluated using paired t-tests. Additionally, changes in sensory and stability categories, which were based on the norm data, were analyzed. Female and male participants showed significantly better sensory and stability indices after skiing. Considerable changes from weak or very weak to average or good balance categories could be seen after skiing for both sexes. Regarding skiing experience, both beginners and intermediate skiers improved their sensory and stability indices significantly after skiing. Hence, recreational alpine skiing resulted in better balance performance regardless of sex or skiing experience. Skiing as an outdoor activity offers the opportunity to improve balance performance with a positive impact on everyday life activities.

Improving mobility : saving lives : safety service patrols

DOT National Transportation Integrated Search

1999-01-01

This brochure describes how safety service patrols can be of value in minimizing disruption of incidents and maximizing traffic flow. The service patrols are equipped to handle emergencies and are a cost effective component of traffic management syst...

Vulnerability assessment of skiing-dependent businesses to the effects of climate change in Banff and Jasper National Parks, Canada

NASA Astrophysics Data System (ADS)

Reynolds, David Michael

This qualitative study examines the potential positive and negative socio-economic impacts that may emerge from the long-term effects of climate change on skiing-dependent businesses in Banff and Jasper National Parks, Canada. My goal was to determine whether or not skiing-related tourism in the parks in the 2020s and 2050s is more or less socio-economically vulnerable to the effects of climate change on snow cover, temperatures and ski season length at ski resorts in the parks. My study explored the level of awareness and personal perceptions of 60 skiing-dependent business managers about how the impact of climate change on ski resorts may influence future socio-economics of ski tourism businesses. I employed a vulnerability assessment approach and adopted some elements of grounded theory. My primary data sources are interviews with managers and the outcome of the geographical factors index (GFI). Supporting methods include: an analysis and interpretation of climate model data and an interpretation of the economic analysis of skiing in the parks. The interview data were sorted and coded to establish concepts and findings by interview questions, while the GFI model rated and ranked 24 regional ski resorts in the Canadian Cordillera. The findings answered the research questions and helped me conclude what the future socio-economic vulnerability may be of skiing-dependent businesses in the parks. The interviews revealed that managers are not informed about climate change and they have not seen any urgency to consider the effects on business. The GFI revealed that the ski resorts in the parks ranked in the top ten of 24 ski resorts in the Cordillera based on 14 common geographical factors. The economic reports suggest skiing is the foundation of the winter economy in the parks and any impact on skiing would directly impact other skiing-dependent businesses. Research indicates that the effects of climate change may have less economic impact on skiing-dependent businesses in Banff and Jasper in the 2020s and 2050s compared with other ski resorts located in the Cordillera. Recommendations are provided to explore future research opportunities and for skiing-dependent businesses and government organizations.

SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Li; Weng, Wei; Sun, Zhi-Xin

Previous studies have identified sphingosine kinase 1 (SphK1) as a potential drug target for treatment of acute myeloid leukemia (AML). In the current study, we investigated the potential anti-leukemic activity of a novel and specific SphK1 inhibitor, SKI-II. We demonstrated that SKI-II inhibited growth and survival of human AML cell lines (HL-60 and U937 cells). SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk. SKI-II treatment inhibited SphK1 activation, andmore » concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells. Conversely, exogenously-added S1P protected against SKI-II-induced cytotoxicity, while cell permeable short-chain ceramide (C6) aggravated SKI-II's lethality against AML cells. Notably, SKI-II induced potent apoptotic death in primary human AML cells, but was generally safe to the human peripheral blood mononuclear cells (PBMCs) isolated from healthy donors. In vivo, SKI-II administration suppressed growth of U937 leukemic xenograft tumors in severe combined immunodeficient (SCID) mice. These results suggest that SKI-II might be further investigated as a promising anti-AML agent. - Highlights: • SKI-II inhibits proliferation and survival of primary and transformed AML cells. • SKI-II induces apoptotic death of AML cells, but is safe to normal PBMCs. • SKI-II is more efficient than two known SphK1 inhibitors in inhibiting AML cells. • SKI-II inhibits SphK1 activity, while increasing ceramide production in AML cells. • SKI-II dose-dependently inhibits U937 xenograft growth in SCID mice.« less

Evaluation of arterial service patrol programs.

DOT National Transportation Integrated Search

2009-12-01

This evaluation of the Arterial Service Patrol named I-64 Traffic Response (TR) is an interim report covering the first full year of operation. This Arterial Service Patrol was part of a regional traffic management strategy to address mobility issues...

Flower-visiting behavior of male bees is triggered by nectar-feeding insects.

PubMed

Sugiura, Shinji; Abe, Tetsuto; Yamaura, Yuichi; Makino, Shun'ichi

2007-08-01

Bees are important pollinators for many flowering plants. Female bees are thought to be more effective pollinators than male bees because they carry much more pollen than males. Males of some solitary bee species are known to patrol near flowers that females visit. Because patrolling males visit flowers to mate or defend their territories, they may function as pollinators. However, the significance of patrolling males to pollination has not been studied. We studied males of a solitary bee, Heriades fulvohispidus (Megachilidae), patrolling near flowers and visiting flowers that attracted nectar-feeding insects, including conspecifics, on the Ogasawara (Bonin) Islands. To test the hypothesis that patrolling male bees may function as pollen vectors, we compared the frequency of visits by H. fulvohispidus to flowers of an endemic plant, Schima mertensiana (Theaceae); comparisons were made among flowers with a dead H. fulvohispidus, a dead beetle, a piece of plastic, and nothing (control flowers). Patrolling H. fulvohispidus more frequently visited flowers with a dead conspecific, a dead beetle, or a piece of plastic than the control flowers. Our experiment demonstrates that nectar-feeding insects (including conspecifics and other insects) enhance the flower-visiting frequency of patrolling H. fulvohispidus males on S. mertensiana flowers. Furthermore, we observed S. mertensiana pollen on patrolling males as well as females, suggesting that male bees may also function as pollen vectors.

Flower-visiting behavior of male bees is triggered by nectar-feeding insects

NASA Astrophysics Data System (ADS)

Sugiura, Shinji; Abe, Tetsuto; Yamaura, Yuichi; Makino, Shun'ichi

2007-08-01

Bees are important pollinators for many flowering plants. Female bees are thought to be more effective pollinators than male bees because they carry much more pollen than males. Males of some solitary bee species are known to patrol near flowers that females visit. Because patrolling males visit flowers to mate or defend their territories, they may function as pollinators. However, the significance of patrolling males to pollination has not been studied. We studied males of a solitary bee, Heriades fulvohispidus (Megachilidae), patrolling near flowers and visiting flowers that attracted nectar-feeding insects, including conspecifics, on the Ogasawara (Bonin) Islands. To test the hypothesis that patrolling male bees may function as pollen vectors, we compared the frequency of visits by H. fulvohispidus to flowers of an endemic plant, Schima mertensiana (Theaceae); comparisons were made among flowers with a dead H. fulvohispidus, a dead beetle, a piece of plastic, and nothing (control flowers). Patrolling H. fulvohispidus more frequently visited flowers with a dead conspecific, a dead beetle, or a piece of plastic than the control flowers. Our experiment demonstrates that nectar-feeding insects (including conspecifics and other insects) enhance the flower-visiting frequency of patrolling H. fulvohispidus males on S. mertensiana flowers. Furthermore, we observed S. mertensiana pollen on patrolling males as well as females, suggesting that male bees may also function as pollen vectors.

Skiing trends

Treesearch

Charles R. Goeldner; Stacy Standley

1980-01-01

A brief historical overview of skiing is presented, followed by a review of factors such as energy, population trends, income, sex, occupation and attitudes which affect the future of skiing. A. C. Neilson's Sports Participation Surveys show that skiing is the second fastest growing sport in the country. Skiing Magazine's study indicates there are...

Ski can negatively regulates macrophage differentiation through its interaction with PU.1

PubMed Central

Ueki, N; Zhang, L; Haymann, MJ

2010-01-01

In the hematopoietic cell system, the oncoprotein Ski dramatically affects growth and differentiation programs, in some cases leading to malignant leukemia. However, little is known about the interaction partners or signaling pathways involved in the Ski-mediated block of differentiation in hematopoietic cells. Here we show that Ski interacts with PU.1, a lineage-specific transcription factor essential for terminal myeloid differentiation, and thereby represses PU.1-dependent transcriptional activation. Consistent with this, Ski inhibits the biological function of PU.1 to promote myeloid cells to differentiate into macrophage colony-stimulating factor receptor (M-CSFR)-positive macrophages. Using a Ski mutant deficient in PU.1 binding, we demonstrate that Ski–PU.1 interaction is critical for Ski's ability to repress PU.1-dependent transcription and block macrophage differentiation. Furthermore, we provide evidence that Ski-mediated repression of PU.1 is due to Ski's ability to recruit histone deacetylase 3 to PU.1 bound to DNA. Since inactivation of PU.1 is closely related to the development of myeloid leukemia and Ski strongly inhibits PU.1 function, we propose that aberrant Ski expression in certain types of myeloid cell lineages might contribute to leukemogenesis. PMID:17621263

Warrants, design, and safety of road ranger service patrols : draft final report.

DOT National Transportation Integrated Search

2016-11-01

This research project created a decision support system for managers who must decide if a roadway warrants the addition of the Safety Service Patrol (SSP). Meetings with Florida Department of Transportation (FDOT) service patrol program manager...

Multi-A Graph Patrolling and Partitioning

NASA Astrophysics Data System (ADS)

Elor, Y.; Bruckstein, A. M.

2012-12-01

We introduce a novel multi agent patrolling algorithm inspired by the behavior of gas filled balloons. Very low capability ant-like agents are considered with the task of patrolling an unknown area modeled as a graph. While executing the proposed algorithm, the agents dynamically partition the graph between them using simple local interactions, every agent assuming the responsibility for patrolling his subgraph. Balanced graph partition is an emergent behavior due to the local interactions between the agents in the swarm. Extensive simulations on various graphs (environments) showed that the average time to reach a balanced partition is linear with the graph size. The simulations yielded a convincing argument for conjecturing that if the graph being patrolled contains a balanced partition, the agents will find it. However, we could not prove this. Nevertheless, we have proved that if a balanced partition is reached, the maximum time lag between two successive visits to any vertex using the proposed strategy is at most twice the optimal so the patrol quality is at least half the optimal. In case of weighted graphs the patrol quality is at least (1)/(2){lmin}/{lmax} of the optimal where lmax (lmin) is the longest (shortest) edge in the graph.

U.S. Border Patrol OCONUS: Possible Contributions to the Whole of Government Approach to Stability Operations

DTIC Science & Technology

2010-06-11

Force–Rural Area Police Patrol Unit (Unidad Móvil Policial Para Reas Rurales) also known as Los Leopardos (the Leopards ). USBP U.S. Border Patrol...99Ibid. 38 Antinarcotics Force--Rural Area Police Patrol Unit (Unidad Móvil Policial Para Reas Rurales) also known as Los Leopardos (the Leopards ). The...training or preparation time for this mission. Upon arrival he found that the inclement cold weather included snow , sleet, ice, and frigid cold

Characterization of chicken c-ski oncogene products expressed by retrovirus vectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutrave, P.; Copeland, T.D.; Hughes, S.H.

1990-06-01

The authors have constructed replication-competent avian retrovirus vectors that contain two of the three known types of chicken c-{ital ski} cDNAs and a third vector that contains a truncated c-{ital ski} cDNA. They developed antisera that recognize the c-{ital ski} proteins made by the three transforming c-{ital ski} viruses. All three proteins (apparent molecular masses, 50, 60, and 90 kilodaltons) are localized primarily in the nucleus. The proteins are differentially phosphorylated; immunofluorescence also suggests that there are differences in subnuclear localization of the c-{ital ski} proteins and that c-{ital ski} protein is associated with condensed chromatin in dividing cells.

Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling.

PubMed

Ueki, Nobuhide; Hayman, Michael J

2003-08-29

The oncoprotein Ski represses transforming growth factor (TGF)-beta signaling in an N-CoR-independent manner. However, the molecular mechanism(s) underlying this event has not been elucidated. Here, we identify an additional domain in Ski that mediates interaction with Smad3 which is important for this repression. This domain is distinct from the previously reported N-terminal Smad3 binding domain in Ski. Individual alanine substitution of several residues in the domain significantly affected Ski-Smad3 interaction. Furthermore, combined mutations within this domain, together with those in the previously identified Smad3 binding domain, can completely abolish the interaction of Ski with Smad3, while mutation in each domain alone retained partial interaction. By introducing those mutations that abolish direct interaction with Smad3 or Smad4 individually, or in combination, we show that interaction of Ski with either Smad3 or Smad4 is sufficient for Ski-mediated repression of TGF-beta signaling. Furthermore our results clearly demonstrate that Ski does not disrupt Smad3-Smad4 heteromer formation, and recruitment of Ski to the Smad3/4 complex through binding to either Smad3 or Smad4 is both necessary and sufficient for repression.

Biomechanical comparison of the double-push technique and the conventional skate skiing technique in cross-country sprint skiing.

PubMed

Stöggl, Thomas; Müller, Erich; Lindinger, Stefan

2008-09-01

The aims of the study were to: (1) adapt the "double-push" technique from inline skating to cross-country skiing; (2) compare this new skiing technique with the conventional skate skiing cross-country technique; and (3) test the hypothesis that the double-push technique improves skiing speed in a short sprint. 13 elite skiers performed maximum-speed sprints over 100 m using the double-push skate skiing technique and using the conventional "V2" skate skiing technique. Pole and plantar forces, knee angle, cycle characteristics, and electromyography of nine lower body muscles were analysed. We found that the double-push technique could be successfully transferred to cross-country skiing, and that this new technique is faster than the conventional skate skiing technique. The double-push technique was 2.9 +/- 2.2% faster (P < 0.001), which corresponds to a time advantage of 0.41 +/- 0.31 s over 100 m. The double-push technique had a longer cycle length and a lower cycle rate, and it was characterized by higher muscle activity, higher knee extension amplitudes and velocities, and higher peak foot forces, especially in the first phase of the push-off. Also, the foot was more loaded laterally in the double-push technique than in the conventional skate skiing technique.

78 FR 38842 - Definition of a Ski Area

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... snow sports. The definition for a ski area in Forest Service regulations at 36 CFR 251.51 implementing... skiing. Accordingly, the Department is amending the definition for a ski area in 36 CFR 251.51 to provide... area in 36 CFR 251.51 that the preponderance of revenue at a ski area derive from activities and...

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements.

PubMed

Suzuki, Hiroyuki; Yagi, Ken; Kondo, Miki; Kato, Mitsuyasu; Miyazono, Kohei; Miyazawa, Keiji

2004-06-24

c-Ski inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. c-Ski represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. c-Ski also inhibits TGF-beta-induced downregulation of genes such as c-myc. However, mechanisms for transcriptional regulation of target genes by c-Ski have not been fully determined. In this study, we examined how c-Ski inhibits both TGF-beta-induced transcriptional activation and repression. DNA-affinity precipitation analysis revealed that c-Ski enhances the binding of Smad2 and 4, and to a lesser extent Smad3, to both CAGA and TGF-beta1 inhibitory element probes. A c-Ski mutant, which is unable to interact with Smad4, failed to enhance the binding of Smad complex on these probes and to inhibit the Smad-responsive promoter. These results suggest that stabilization of inactive Smad complexes on DNA is a critical event in c-Ski-mediated inhibition of TGF-beta signaling.

Novel Regulation of Ski Protein Stability and Endosomal Sorting by Actin Cytoskeleton Dynamics in Hepatocytes*

PubMed Central

Vázquez-Victorio, Genaro; Caligaris, Cassandre; Del Valle-Espinosa, Eugenio; Sosa-Garrocho, Marcela; González-Arenas, Nelly R.; Reyes-Cruz, Guadalupe; Briones-Orta, Marco A.; Macías-Silva, Marina

2015-01-01

TGF-β-induced antimitotic signals are highly regulated during cell proliferation under normal and pathological conditions, such as liver regeneration and cancer. Up-regulation of the transcriptional cofactors Ski and SnoN during liver regeneration may favor hepatocyte proliferation by inhibiting TGF-β signals. In this study, we found a novel mechanism that regulates Ski protein stability through TGF-β and G protein-coupled receptor (GPCR) signaling. Ski protein is distributed between the nucleus and cytoplasm of normal hepatocytes, and the molecular mechanisms controlling Ski protein stability involve the participation of actin cytoskeleton dynamics. Cytoplasmic Ski is partially associated with actin and localized in cholesterol-rich vesicles. Ski protein stability is decreased by TGF-β/Smads, GPCR/Rho signals, and actin polymerization, whereas GPCR/cAMP signals and actin depolymerization promote Ski protein stability. In conclusion, TGF-β and GPCR signals differentially regulate Ski protein stability and sorting in hepatocytes, and this cross-talk may occur during liver regeneration. PMID:25561741

Physics and Skiing.

ERIC Educational Resources Information Center

Swinson, Derek B.

1992-01-01

Presents examples of physics as applied to the sport of skiing. Examples examine the physics of sliding, unweighting, ski turning, wind resistance, the parabolic and circular motion of aerial skiers, and the aerial maneuvers of ski jumpers. (MDH)

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor

PubMed Central

Xu, Weidong; Angelis, Konstantina; Danielpour, David; Haddad, Maher M.; Bischof, Oliver; Campisi, Judith; Stavnezer, Ed; Medrano, Estela E.

2000-01-01

The c-ski protooncogene encodes a transcription factor that binds DNA only in association with other proteins. To identify co-binding proteins, we performed a yeast two-hybrid screen. The results of the screen and subsequent co-immunoprecipitation studies identified Smad2 and Smad3, two transcriptional activators that mediate the type β transforming growth factor (TGF-β) response, as Ski-interacting proteins. In Ski-transformed cells, all of the Ski protein was found in Smad3-containing complexes that accumulated in the nucleus in the absence of added TGF-β. DNA binding assays showed that Ski, Smad2, Smad3, and Smad4 form a complex with the Smad/Ski binding element GTCTAGAC (SBE). Ski repressed TGF-β-induced expression of 3TP-Lux, the natural plasminogen activator inhibitor 1 promoter and of reporter genes driven by the SBE and the related CAGA element. In addition, Ski repressed a TGF-β-inducible promoter containing AP-1 (TRE) elements activated by a combination of Smads, Fos, and/or Jun proteins. Ski also repressed synergistic activation of promoters by combinations of Smad proteins but failed to repress in the absence of Smad4. Thus, Ski acts in opposition to TGF-β-induced transcriptional activation by functioning as a Smad-dependent co-repressor. The biological relevance of this transcriptional repression was established by showing that overexpression of Ski abolished TGF-β-mediated growth inhibition in a prostate-derived epithelial cell line. PMID:10811875

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor.

PubMed

Xu, W; Angelis, K; Danielpour, D; Haddad, M M; Bischof, O; Campisi, J; Stavnezer, E; Medrano, E E

2000-05-23

The c-ski protooncogene encodes a transcription factor that binds DNA only in association with other proteins. To identify co-binding proteins, we performed a yeast two-hybrid screen. The results of the screen and subsequent co-immunoprecipitation studies identified Smad2 and Smad3, two transcriptional activators that mediate the type beta transforming growth factor (TGF-beta) response, as Ski-interacting proteins. In Ski-transformed cells, all of the Ski protein was found in Smad3-containing complexes that accumulated in the nucleus in the absence of added TGF-beta. DNA binding assays showed that Ski, Smad2, Smad3, and Smad4 form a complex with the Smad/Ski binding element GTCTAGAC (SBE). Ski repressed TGF-beta-induced expression of 3TP-Lux, the natural plasminogen activator inhibitor 1 promoter and of reporter genes driven by the SBE and the related CAGA element. In addition, Ski repressed a TGF-beta-inducible promoter containing AP-1 (TRE) elements activated by a combination of Smads, Fos, and/or Jun proteins. Ski also repressed synergistic activation of promoters by combinations of Smad proteins but failed to repress in the absence of Smad4. Thus, Ski acts in opposition to TGF-beta-induced transcriptional activation by functioning as a Smad-dependent co-repressor. The biological relevance of this transcriptional repression was established by showing that overexpression of Ski abolished TGF-beta-mediated growth inhibition in a prostate-derived epithelial cell line.

Tank Investigation of the EDO Model 142 Hydro-Ski Research Airplane

NASA Technical Reports Server (NTRS)

Ramsen, John A.; Wadlin, Kenneth L.; Gray, George R.

1951-01-01

A tank investigation has been conducted of a 1/10-size powered-dynamic model of the Edo model 142 hydra-ski research airplane. The results of tests of two configurations are presented: One included a large ski and a ski well; the other, a small ski without a well. Water take-offs would be possible with the available thrust for either configuration: however, the configuration with the large ski emerged sooner and had less resistance from ski emergence until take-off. Longitudinal stability and landing behavior in smooth water were satisfactory for both configurations. Some alteration to the design of the tail would be desirable in order to reduce the spray loads.

A sit-ski design aimed at controlling centre of mass and inertia.

PubMed

Langelier, Eve; Martel, Stéphane; Millot, Anne; Lessard, Jean-Luc; Smeesters, Cécile; Rancourt, Denis

2013-01-01

This article introduces a sit-ski developed for the Canadian Alpine Ski Team in view of the Vancouver 2010 Paralympic games. The design is predominantly based on controlling the mass distribution of the sit-ski, a critical factor in skiing performance and control. Both the antero-posterior location of the centre of mass and the sit-ski moment of inertia were addressed in our design. Our design provides means to adjust the antero-posterior centre of mass location of a sit-ski to compensate for masses that would tend to move the antero-posterior centre of mass location away from the midline of the binding area along the ski axis. The adjustment range provided is as large as 140 mm, thereby providing sufficient adaptability for most situations. The suspension mechanism selected is a four-bar linkage optimised to limit antero-posterior seat movement, due to suspension compression, to 7 mm maximum. This is about 5% of the maximum antero-posterior centre of mass control capacity (151 mm) of a human participant. Foot rest inclination was included in the design to modify the sit-ski inertia by as much as 11%. Together, these mass adjustment features were shown to drastically help athletes' skiing performance.

Numerical investigation of the early flight phase in ski-jumping.

PubMed

Gardan, N; Schneider, A; Polidori, G; Trenchard, H; Seigneur, J M; Beaumont, F; Fourchet, F; Taiar, R

2017-07-05

The purpose of this study is to develop a numerical methodology based on real data from wind tunnel experiments to investigate the effect of the ski jumper's posture and speed on aerodynamic forces in a wide range of angles of attack. To improve our knowledge of the aerodynamic behavior of the ski jumper and his equipment during the early flight phase of the ski jump, we applied CFD methodology to evaluate the influence of angle of attack (α=14°, 21.5°, 29°, 36.5° and 44°) and speed (u=23, 26 and 29m/s) on aerodynamic forces in the situation of stable attitude of the ski jumper's body and skis. The standard k-ω turbulence model was used to investigate both the influence of the ski jumper's posture and speed on aerodynamic performance during the early flight phase. Numerical results show that the ski jumper's speed has very little impact on the lift and drag coefficients. Conversely, the lift and drag forces acting on the ski jumper's body during the early flight phase of the jump are strongly influenced by the variations of the angle of attack. The present results suggest that the greater the ski jumper's angle of inclination, with respect to the relative flow, the greater the pressure difference between the lower and upper parts of the skier. Further studies will focus on the dependency of the parameters with both the angle of attack α and the body-ski angle β as control variables. It will be possible to test and optimize different ski jumping styles in different ski jumping hills and investigate different environmental conditions such as temperature, altitude or crosswinds. Copyright © 2017 Elsevier Ltd. All rights reserved.

Effect of SKI2670, a novel, orally active, non-peptide GnRH antagonist, on hypothalamic-pituitary-gonadal axis.

PubMed

Kim, Seon Mi; Yoo, Taekyung; Lee, So Young; Kim, Eun Jeong; Lee, Soo Min; Lee, Min Hee; Han, Min Young; Jung, Seung-Hyun; Choi, Jung-Hye; Ryu, Keun Ho; Kim, Hun-Taek

2015-10-15

Suppression of the hypothalamic-pituitary-gonadal axis has been widely utilized for the management of gonadal-hormone-dependent diseases such as endometriosis. Efforts to develop orally available gonadotropin-releasing hormone (GnRH) antagonists for the treatment of gonadal-hormone-dependent diseases led to the discovery of SKI2670, a novel non-peptide GnRH antagonist. The present study was undertaken to pharmacologically characterize SKI2670 in vitro and in vivo. We measured binding affinity and antagonistic activity of SKI2670 for the GnRH receptors. Immediate suppression of gonadotropins by single dosing of SKI2670 was examined in castrated monkeys. Subsequently, influence on gonadal hormones by prolonged administration of SKI2670 was assessed in naive female monkeys. To investigate in vivo efficacy of SKI2670, regression of ectopic implants by repeated administration of SKI2670 was examined in a rat endometriosis model. SKI2670 is a potent functional antagonist for the human GnRH receptor, with subnanomolar binding affinity. In castrated monkeys, single administration of SKI2670 lowered serum luteinizing hormone (LH) levels stronger with longer duration when compared to elagolix at equivalent doses. Moreover, repeated dosing of SKI2670 suppressed serum levels of gonadotropins and gonadal hormones in intact female monkeys while elagolix suppressed serum LH levels only. Finally, it exhibited regressive effects on ectopic implants in a rat endometriosis model without bone loss. Our findings demonstrate robust GnRH antagonistic efficacy of SKI2670 in animal models, suggesting that SKI2670-induced suppression of the hypothalamic-pituitary-gonadal axis may be beneficial for the treatment of gonadal-hormone-dependent diseases such as endometriosis in humans. Copyright © 2015 Elsevier Inc. All rights reserved.

46 CFR 193.05-1 - Fire detecting, manual alarm, and supervised patrol systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Fire detecting, manual alarm, and supervised patrol...) OCEANOGRAPHIC RESEARCH VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 193.05-1 Fire detecting, manual alarm, and supervised patrol systems. (a) Fire detecting, manual...

46 CFR 193.05-1 - Fire detecting, manual alarm, and supervised patrol systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Fire detecting, manual alarm, and supervised patrol...) OCEANOGRAPHIC RESEARCH VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 193.05-1 Fire detecting, manual alarm, and supervised patrol systems. (a) Fire detecting, manual...

46 CFR 193.05-1 - Fire detecting, manual alarm, and supervised patrol systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Fire detecting, manual alarm, and supervised patrol...) OCEANOGRAPHIC RESEARCH VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 193.05-1 Fire detecting, manual alarm, and supervised patrol systems. (a) Fire detecting, manual...

46 CFR 193.05-1 - Fire detecting, manual alarm, and supervised patrol systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Fire detecting, manual alarm, and supervised patrol...) OCEANOGRAPHIC RESEARCH VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 193.05-1 Fire detecting, manual alarm, and supervised patrol systems. (a) Fire detecting, manual...

46 CFR 95.05-1 - Fire detecting, manual alarm, and supervised patrol systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Fire detecting, manual alarm, and supervised patrol... AND MISCELLANEOUS VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 95.05-1 Fire detecting, manual alarm, and supervised patrol systems. (a) Fire detecting, manual...

46 CFR 95.05-1 - Fire detecting, manual alarm, and supervised patrol systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Fire detecting, manual alarm, and supervised patrol... AND MISCELLANEOUS VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 95.05-1 Fire detecting, manual alarm, and supervised patrol systems. (a) Fire detecting, manual...

46 CFR 193.05-1 - Fire detecting, manual alarm, and supervised patrol systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Fire detecting, manual alarm, and supervised patrol...) OCEANOGRAPHIC RESEARCH VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 193.05-1 Fire detecting, manual alarm, and supervised patrol systems. (a) Fire detecting, manual...

46 CFR 95.05-1 - Fire detecting, manual alarm, and supervised patrol systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Fire detecting, manual alarm, and supervised patrol... AND MISCELLANEOUS VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 95.05-1 Fire detecting, manual alarm, and supervised patrol systems. (a) Fire detecting, manual...

46 CFR 169.821 - Patrol person.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Patrol person. 169.821 Section 169.821 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Operations § 169.821 Patrol person. (a) The master shall designate a member of the ship's company to be a roving...

46 CFR 169.821 - Patrol person.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Patrol person. 169.821 Section 169.821 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Operations § 169.821 Patrol person. (a) The master shall designate a member of the ship's company to be a roving...

Forensic science information needs of patrol officers: The perceptions of the patrol officers, their supervisors and administrators, detectives, and crime scene technicians

NASA Astrophysics Data System (ADS)

Aydogdu, Eyup

Thanks to the rapid developments in science and technology in recent decades, especially in the past two decades, forensic sciences have been making invaluable contributions to criminal justice systems. With scientific evaluation of physical evidence, policing has become more effective in fighting crime and criminals. On the other hand, law enforcement personnel have made mistakes during the detection, protection, collection, and evaluation of physical evidence. Law enforcement personnel, especially patrol officers, have been criticized for ignoring or overlooking physical evidence at crime scenes. This study, conducted in a large American police department, was aimed to determine the perceptions of patrol officers, their supervisors and administrators, detectives, and crime scene technicians about the forensic science needs of patrol officers. The results showed no statistically significant difference among the perceptions of the said groups. More than half of the respondents perceived that 14 out of 16 areas of knowledge were important for patrol officers to have: crime scene documentation, evidence collection, interviewing techniques, firearm evidence, latent and fingerprint evidence, blood evidence, death investigation information, DNA evidence, document evidence, electronically recorded evidence, trace evidence, biological fluid evidence, arson and explosive evidence, and impression evidence. Less than half of the respondents perceived forensic entomology and plant evidence as important for patrol officers.

Chemical exposure among professional ski waxers--characterization of individual work operations.

PubMed

Freberg, Baard Ingegerdsson; Olsen, Raymond; Thorud, Syvert; Ellingsen, Dag G; Daae, Hanne Line; Hersson, Merete; Molander, Paal

2013-04-01

Preparation of skis prior to skiing competitions involves several individual work operations and the use of a wide variety of chemically based ski waxing products to improve the performance of the skis, including products used after skiing for wax removal and ski sole cleaning. Modern ski waxes consist mainly of petroleum-derived straight-chain aliphatic hydrocarbons, perfluoro-n-alkanes or polyfluorinated n-alkanes. The wax cleaning products contain solvents such as neat aliphatic hydrocarbons (aliphates) or a mixture with limonene. Different ski waxing work operations can result in contaminated workroom atmospheres. The aim of this study was to assess the chemical exposures related to the individual ski waxing work operations by investigating the specific work operations in controlled model experiments. Four main work operations with potential exposures were identified: (i) application of glider waxes, (ii) scraping and brushing of applied glider waxes, (iii) application of base/grip waxes, and (iv) ski sole cleaning. Aerosol particle masses were sampled using conical samplers equipped with 37-mm PVC, 5-µm pore size filters and cyclones equipped with 37-mm PVC, 0.8-µm pore size filters for the inhalable and the respirable aerosol mass fractions, respectively. For measurements of particle number concentrations, a Scanning Mobility Particle Sizer was used. Mean aerosol particle mass concentrations of 18.6 mg m(-3) and 32.2 mg m(-3) were measured during application of glider wax powders in the respirable and in the inhalable aerosol mass fractions, respectively. Particle number concentration of ~900 000 particles cm(-3) was measured during application of glider wax powder products. Ski sole cleaning with products containing aliphates displayed solvent air concentrations up to 62.5 p.p.m. This study shows that the potential exposure to generated particles during ski waxing and ski preparation is considerable, especially during work using glide wax powders.

Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.

PubMed

Wu, Jia Wei; Krawitz, Ariel R; Chai, Jijie; Li, Wenyu; Zhang, Fangjiu; Luo, Kunxin; Shi, Yigong

2002-11-01

The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with that required for binding of the R-Smads. Indeed, Ski disrupts the formation of a functional complex between the Co- and R-Smads, explaining how it could lead to repression of TGF-beta, activin, and BMP responses. Intriguingly, the structure of the Ski fragment, stabilized by a bound zinc atom, resembles the SAND domain, in which the corresponding I loop is responsible for DNA binding.

[Ski and SnoN: antagonistic proteins of TGFbeta signaling].

PubMed

Vignais, M L

2000-02-01

Ski and SnoN are two proto-oncogenes that, at high cellular concentrations, are associated with tumors. Up to now, apart the fact that SnoN and Ski were known to bind to DNA indirectly, very little was known about the mechanism which enables these factors to induce tumorigenesis. We know now that SnoN and Ski interact with the SMAD proteins which are mediators of TGFbeta signaling. These SMADs enable recruitment to target gene promoters of SnoN and Ski as well as the histone deacetylase activity which is associated with them. Whereas physiologic concentrations of SnoN and Ski allow a feedback regulation of TGFbeta signaling, deregulation of SnoN or Ski expression leads to total inhibition of TGFbeta signaling and of the tumor suppressors Smad2 and Smad4, which can explain the role of SnoN and Ski as oncogenes.

Involvement of the c-Ski oncoprotein in cell cycle arrest and transformation during nurse cell formation after Trichinella spiralis infection.

PubMed

Wu, Z; Nagano, I; Boonmars, T; Takahashi, Y

2006-09-01

The role of c-Ski, an oncoprotein encoded by the oncogene, c-ski, in Trichinella spiralis-infected muscle tissues during nurse cell formation, was investigated by following the expression kinetics and distribution of c-Ski (both protein and mRNA) in the infected muscle cell, as well as the expression kinetics of the transforming growth factor beta (TGF-beta) signaling pathway factor genes (TGF-beta, Smad2 and Smad4) which cooperate with c-Ski. Immunohistochemical analysis using an anti-c-Ski antibody indicated that in the early stages of infection (13 and 18 days post-infection (p.i.)) the increased expression of the c-Ski protein was limited to the eosinophilic cytoplasm and not the enlarged nuclei or basophilic cytoplasm. At a later stage of infection (23 and 28 days p.i.) the c-Ski protein was limited to the enlarged nuclei in the basophilic cytoplasm, rather than the eosinophilic cytoplasm. At 48 days p.i., the c-Ski protein was barely detectable. Real-time PCR analysis showed that expression of the c-ski gene increased from 13 days p.i., reached a peak at 23-28 days p.i. and then decreased to a low level by 48 days p.i. Expression kinetics for the TGF-beta signaling pathway factor genes (TGF-beta, Smad2 and Smad4) were similar to that of c-ski. These findings provide evidence that the c-Ski protein is involved in nurse cell formation through the TGF-beta signaling pathway process in the host cell nucleus.

A Comparison between Alpine Skiing, Cross-Country Skiing and Indoor Cycling on Cardiorespiratory and Metabolic Response

PubMed Central

Stöggl, Thomas; Schwarzl, Christoph; Müller, Edith E.; Nagasaki, Masaru; Stöggl, Julia; Scheiber, Peter; Schönfelder, Martin; Niebauer, Josef

2016-01-01

Since physical inactivity especially prevails during winter months, we set out to identify outdoor alternatives to indoor cycling (IC) by comparing the metabolic and cardiorespiratory responses during alpine skiing (AS), cross-country skiing (XCS) and IC and analyse the effects of sex, age and fitness level in this comparison. Twenty one healthy subjects performed alpine skiing (AS), cross-country skiing (XCS), and IC. Oxygen uptake (VO2), total energy expenditure (EE), heart rate (HR), lactate, blood glucose and rate of perceived exertion (RPE) were determined during three 4-min stages of low, moderate and high intensity. During XCS and IC VO2max and EE were higher than during AS. At least 2½ hours of AS are necessary to reach the same EE as during one hour of XCS or IC. HR, VO2, lactate, and RPEarms were highest during XCS, whereas RPEwhole-body was similar and RPElegs lower than during AS and IC, respectively. Weight adjusted VO2 and EE were higher in men than in women while fitness level had no effect. Male, fit and young participants were able to increase their EE and VO2 values more pronounced. Both AS and XCS can be individually tailored to serve as alternatives to IC and may thus help to overcome the winter activity deficit. XCS was found to be the most effective activity for generating a high EE and VO2 while AS was the most demanding activity for the legs. Key points During cross-country skiing and indoor cycling VO2max and energy expenditure were higher than during alpine skiing Approximately 2½ hours of alpine skiing are necessary to reach the same energy expenditure of one hour of cross-country skiing or indoor cycling. Alpine skiing and cross-country skiing can be individually tailored to serve as sports alternatives in winter to activity deficit. By applying different skiing modes as parallel ski steering, carving long radii and short turn skiing, metabolic and cardiorespiratory response can be increased during alpine skiing. Male, fit and young participants were able to increase their energy expenditure and VO2 more pronounced with an increase in intensity compared with their counterparts PMID:26957942

SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta.

PubMed

Lin, Qiushi; Chen, Dahu; Timchenko, Nikolai A; Medrano, Estela E

2010-05-01

The transcriptional co-regulator SKI is a potent inhibitor of TGFbeta-growth inhibitory signals. SKI binds to receptor-activated Smads in the nucleus, forming repressor complexes containing HDACs, mSin3, NCoR, and other protein partners. Alternatively, SKI binds to activated Smads in the cytoplasm, preventing their nuclear translocation. SKI is necessary for anchorage-independent growth of melanoma cells in vitro, and most important, for human melanoma xenograft growth in vivo. We recently identified a novel role of SKI in TGFbeta signaling. SKI promotes the switch of Smad3 from repressor of proliferation to activator of oncogenesis by facilitating phosphorylations in the linker domain. High levels of endogenous SKI are required by the tumor promoting trait of TGFbeta to induce expression of the plasminogen-activator inhibitor-1 (PAI-1), sustained expression of C-Myc and for aborting upregulation of p21(Waf-1). Here we discuss how SKI diversifies and amplifies its functions by associating with multiple protein partners and by promoting Smad3 linker phosphorylation(s) in response to TGFbeta signaling in melanoma cells.

Tank Investigation of the Grumman JRF-5 Airplane Equipped with Twin Hydro-Skis TED No. NACA DE 357

NASA Technical Reports Server (NTRS)

Ramsen, John A.; Gray, George R.

1951-01-01

A tank investigation has been conducted on a 1/8-size powered dynamic model of the Grumman JRF-5 airplane equipped with twin hydro-skis. The results of tests using two types of skis are presented: one had vertical sides joining the top surface to the chine; the other had the top surface faired to the chine to eliminate the vertical sides. Both configurations had satisfactory longitudinal stability although the model had a slightly greater stable elevator range available when the skis without the vertical sides were attached. Free model tests indicated no instability present when one ski emerged before the other. Considerable excess thrust was available at all speeds with either type of skis. A hump gross load-resistance ratio of 3.37 was obtained with the skis with the vertical sides and 3.53 with the other skis. Landing behavior in smooth water with yaw up to 15deg and roll up to 15deg in opposite directions was satisfactory with either type of skis.

Exertion injuries in adolescent athletes.

PubMed

Orava, S; Puranen, J

1978-03-01

A series of 147 cases of exertion injuries in less than or equal to 15 years old athletes is presented. All injuries occurred during training or athletic performances without trauma and caused symptoms that prevented athletic exercises. There were 67 girls (46%) and 80 boys (54%) in the material. About 90% of them had been training for more than one year before the onset of the symptoms; 65% were interested in track and field athletics, 13% in ball games, 11% in skiing, 4% in swimming, and 3% in orienteering. The rest were interested in other sports. About 33% of the injuries were growth disturbances or osteochondroses seen also in other children. About 15% were anomalies, deformities or earlier osteochondritic changes, which caused first symptoms during the physical exercise; 50% were typical overuse injuries that may bother adult athletes, too; 43% of the injuries were localized in ankle, foot and heel, 31% in knee, 8% in back and trunk, 7% in pelvic and hip region, and the rest in other parts of the body. The injuries were generally slight, no permanent disability was noticed. Rest and conservation therapy cured most cases; operative treatment was used in only eight cases.

Athlete exertion injuries.

PubMed

Orava, S; Puranen, J

1978-01-01

Over a period of three years 829 cases of greater than or equal to 16-year-old athlete exertion injuries and syndromes were collected. There were 75 women and 754 men in the series. About 90% of the athletes had been training regularly for more than two years, and 75% of them trained 6 times a week or more. Approximately 52% of the injuries occurred in track and field athletics, about 17% in ball events, 13.6% in skiing, 7.4% in orienteering, and 4.7% in power events. Other sports were associated with fewer exertion injuries. 28.7% of the conditions occurred in the knee, 17% in the ankle, foot and heel, 14.8% in the leg, 8.2% in the back and trunk, 8.1% in the thigh, 7.4% in the achilles tendon. The rest were in the shoulder, neck and upper extremities. In 92% of the patients conservative treatment and rest were used. Only 8% of the cases were treated surgically.

78 FR 21610 - Expansion Funds for the Support of the Senior Medicare Patrol (SMP) Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... the Support of the Senior Medicare Patrol (SMP) Program ACTION: Notice of intent to provide expansion... funds for the support of the Senior Medicare Patrol (SMP) Program. This additional funding opportunity... program capacity to recruit, train, and support the SMP volunteer network. In addition, this funding...

Integrating mobile GIS, real-time D-GPS, and high-resolution satellite imagery for land use patrolling

NASA Astrophysics Data System (ADS)

Xu, Zhu; Chen, Xianwei; Liu, Guoxiang; Chen, Tao; Meng, Yanzi; Jiang, Lianjiang; Wang, Mei

2009-06-01

The illegal use of lands has come to impose a serious threat to land resources protection and land use plan implementation in China. Land use patrolling has long been proven to be an effective means for detection, investigation and prevention of illegal land use. However, land use patrolling performed in the traditional way is laborious and cumbersome. Central and regional government authorities are both seeking high-technology solution to enhance this job. In an effort to satisfy such requirements, we have designed and implemented an integrated system of mobile GIS, D-GPS and wireless Internet to assist land use patrolling and investigation. Details of this system are presented in this paper, including those of the system architecture, the field work-assisting subsystem, the Internet-based D-GPS subsystem ... etc. The main finding is that such technology is indispensable for land use patrolling and similar tasks. It can dramatically promote the patrolling or field work efficiency and tightly connect field and office staff to better perform the mission. Problems encountered in building the system are also discussed.

Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5.

PubMed

Tabata, Takanori; Kokura, Kenji; Ten Dijke, Peter; Ishii, Shunsuke

2009-01-01

The products encoded by ski and its related gene, sno, (Ski and Sno) act as transcriptional co-repressors and interact with other co-repressors such as N-CoR/SMRT and mSin3A. Ski and Sno mediate transcriptional repression by various repressors, including Mad, Rb and Gli3. Ski/Sno also suppress transcription induced by multiple activators, such as Smads and c-Myb. In particular, the inhibition of TGF-beta-induced transcription by binding to Smads is correlated with the oncogenic activity of Ski and Sno. However, the molecular mechanism by which Ski and Sno mediate transcriptional repression remains unknown. In this study, we report the purification and characterization of Ski complexes. The Ski complexes purified from HeLa cells contained histone deacetylase 3 (HDAC3) and protein arginine methyltransferase 5 (PRMT5), in addition to multiple Smad proteins (Smad2, Smad3 and Smad4). Chromatin immunoprecipitation assays indicated that these components of the Ski complexes were localized on the SMAD7 gene promoter, which is the TGF-beta target gene, in TGF-beta-untreated HepG2 cells. Knockdown of these components using siRNA led to up-regulation of SMAD7 mRNA. These results indicate that Ski complexes serve to maintain a TGF-beta-responsive promoter at a repressed basal level via the activities of histone deacetylase and histone arginine methyltransferase.

Skiing in the Great Lakes States: the industry and the skier.

Treesearch

William A. Leuschner

1970-01-01

Describes the skiers and ski areas in the Midwest. Analyzes market structure for the industry, the factors associated with financial success, the impact of spending on local economies, and the potential of ski area investment. Includes ski area financial statements.

Chinese Arms Production and Sales for the Third World

DTIC Science & Technology

1991-01-01

Egypt J-6 fighter 60 Guinea Shanghai-class patrol boat 4 Kampuchea (Khmer Rouge) Type-59 MBT NA HJ-73 ATGW 200+ J-5 fighter 4 J-6 fighter 16 North Korea...Shanghai-class patrol boat 6 Tunisia Shanghai-class patrol boat 2 Zaire T-62 light tank 50 Type-56/-59/- 60 /-63 arty 80 Huanchen-class FAC(T) 4 Zambia T-59...fighter 75+ J-7 fighter 60 Chaho-class patrol boat 3 HY-2/FL-1 antishipping missile 72+ C-801 antishipping missile 100 Iraq Type-59 MBT 1000 Type-69 MBT

Do Maximal Roller Skiing Speed and Double Poling Performance Predict Youth Cross-Country Skiing Performance?

PubMed Central

Stöggl, Roland; Müller, Erich; Stöggl, Thomas

2017-01-01

The aims of the current study were to analyze whether specific roller skiing tests and cycle length are determinants of youth cross-country (XC) skiing performance, and to evaluate sex specific differences by applying non-invasive diagnostics. Forty-nine young XC skiers (33 boys; 13.8 ± 0.6 yrs and 16 girls; 13.4 ± 0.9 yrs) performed roller skiing tests consisting of both shorter (50 m) and longer durations (575 m). Test results were correlated with on snow XC skiing performance (PXC) based on 3 skating and 3 classical distance competitions (3 to 6 km). The main findings of the current study were: 1) Anthropometrics and maturity status were related to boys’, but not to girls’ PXC; 2) Significant moderate to acceptable correlations between girls’ and boys’ short duration maximal roller skiing speed (double poling, V2 skating, leg skating) and PXC were found; 3) Boys’ PXC was best predicted by double poling test performance on flat and uphill, while girls’ performance was mainly predicted by uphill double poling test performance; 4) When controlling for maturity offset, boys’ PXC was still highly associated with the roller skiing tests. The use of simple non-invasive roller skiing tests for determination of PXC represents practicable support for ski clubs, schools or skiing federations in the guidance and evaluation of young talent. Key points Double poling tests on flat and uphill terrain and short duration maximal speed tests were the highest cross-country skiing predicting factors in girls and boys. Only in the boys there was an effect of maturation on the performance outcomes, pointing out that girls seem to be almost fully matured at the age of 13 in contrast to the boys. Roller skiing tests over short distance (50-m) and longer distance 225 m and 350 m are stable and valid measures and suitable for performance prediction in youth cross-country skiers. PMID:28912656

Characterization of Course and Terrain and Their Effect on Skier Speed in World Cup Alpine Ski Racing

PubMed Central

Gilgien, Matthias; Crivelli, Philip; Spörri, Jörg; Kröll, Josef; Müller, Erich

2015-01-01

World Cup (WC) alpine ski racing consists of four main competition disciplines (slalom, giant slalom, super-G and downhill), each with specific course and terrain characteristics. The International Ski Federation (FIS) has regulated course length, altitude drop from start to finish and course setting in order to specify the characteristics of the respective competition disciplines and to control performance and injury-related aspects. However to date, no detailed data on course setting and its adaptation to terrain is available. It is also unknown how course and terrain characteristics influence skier speed. Therefore, the aim of the study was to characterize course setting, terrain geomorphology and their relationship to speed in male WC giant slalom, super-G and downhill. The study revealed that terrain was flatter in downhill compared to the other disciplines. In all disciplines, variability in horizontal gate distance (gate offset) was larger than in gate distance (linear distance from gate to gate). In giant slalom the horizontal gate distance increased with terrain inclination, while super-G and downhill did not show such a connection. In giant slalom and super-G, there was a slight trend towards shorter gate distances as the steepness of the terrain increased. Gates were usually set close to terrain transitions in all three disciplines. Downhill had a larger proportion of extreme terrain inclination changes along the skier trajectory per unit time skiing than the other disciplines. Skier speed decreased with increasing steepness of terrain in all disciplines except for downhill. In steep terrain, speed was found to be controllable by increased horizontal gate distances in giant slalom and by shorter gate distances in giant slalom and super-G. Across the disciplines skier speed was largely explained by course setting and terrain inclination in a multiple linear model. PMID:25760039

Selection for protection in an ant–plant mutualism: host sanctions, host modularity, and the principal–agent game

PubMed Central

Edwards, David P; Hassall, Mark; Sutherland, William J; Yu, Douglas W

2005-01-01

Retaliation against cheaters can prevent the breakdown of cooperation. Here we ask whether the ant–plant Cordia nodosa is able to apply retaliatory sanctions against its ant symbiont Allomerus octoarticulatus, which patrols new shoots to prevent herbivory. We test the hypothesis that the modular design of C. nodosa physiologically ties the growth of housing (stem swellings known as domatia) to the successful development of the attached leaves. We experimentally simulated herbivory by cutting leaves from patrolled shoots and found that the domatia on such ‘cheated’ shoots suffered higher mortality and lower growth than did controls, evidence for a host sanction. On the other hand, patrolling is costly to the ant, and experiment shows that non-patrollers run a low risk of being sanctioned because most leaves (and the attached domatia) escape heavy herbivory even when patrollers are absent. This suggests that cheaters might enjoy a higher fitness than do mutualists, despite sanctions, but we find that patrolling provides a net fecundity benefit when the colony and plant exceed a minimum size, which requires sustained ant investment in patrolling. These results map directly onto the principal–agent (P–A) game from economics, which we suggest can be used as a framework for studying stability in mutualisms, where high sampling costs and cheating do not allow market effects to select for mutual benefits. PMID:16537131

Selection for protection in an ant-plant mutualism: host sanctions, host modularity, and the principal-agent game.

PubMed

Edwards, David P; Hassall, Mark; Sutherland, William J; Yu, Douglas W

2006-03-07

Retaliation against cheaters can prevent the breakdown of cooperation. Here we ask whether the ant-plant Cordia nodosa is able to apply retaliatory sanctions against its ant symbiont Allomerus octoarticulatus, which patrols new shoots to prevent herbivory. We test the hypothesis that the modular design of C. nodosa physiologically ties the growth of housing (stem swellings known as domatia) to the successful development of the attached leaves. We experimentally simulated herbivory by cutting leaves from patrolled shoots and found that the domatia on such 'cheated' shoots suffered higher mortality and lower growth than did controls, evidence for a host sanction. On the other hand, patrolling is costly to the ant, and experiment shows that non-patrollers run a low risk of being sanctioned because most leaves (and the attached domatia) escape heavy herbivory even when patrollers are absent. This suggests that cheaters might enjoy a higher fitness than do mutualists, despite sanctions, but we find that patrolling provides a net fecundity benefit when the colony and plant exceed a minimum size, which requires sustained ant investment in patrolling. These results map directly onto the principal-agent (P-A) game from economics, which we suggest can be used as a framework for studying stability in mutualisms, where high sampling costs and cheating do not allow market effects to select for mutual benefits.

Coast Guard Cutter Procurement: Background and Issues for Congress

DTIC Science & Technology

2015-07-28

Research Service Summary The Coast Guard’s program of record (POR) calls for procuring 8 National Security Cutters (NSCs), 25 Offshore Patrol Cutters...3 Figure 2. Offshore Patrol Cutter (Generic Conceptual... Offshore Patrol Cutters (OPCs), and 58 Fast Response Cutters (FRCs). These 91 planned cutters are intended as replacements for 90 aging Coast Guard cutters

PRELIMINARY FINDINGS ON THE ASSESSMENT OF POTENTIAL CAR-RELATED OCCUPATIONAL PM AND AIR TOXIC EXPOSURE TO PATROL TROOPERS (COPP STUDY)

EPA Science Inventory

In-vehicle, roadside and community-based measurements of particulate matter (PM) and select air toxics were measured as part of a study involving patrol cars from the North Carolina Highway Patrol. One goal of this study was to characterize PM and related air pollutant concentra...

Flying High With Civil Air Patrol: The Sierra Blanca Civil Air Patrol Squadron.

ERIC Educational Resources Information Center

Carnicom, Gene E.

The Sierra Blanca Civil Air Patrol (CAP) Cadet Squadron from Mescalero, New Mexico, is a program funded by the tribe and the state of New Mexico for Mescalero Apache youth. The national CAP Cadet Program promotes moral leadership, aerospace education, leadership, and physical fitness; Mescalero cadets have learned self-confidence and leadership…

Balancing Play, Meaning and Reality: The Design Philosophy of LEVEE PATROLLER

ERIC Educational Resources Information Center

Harteveld, Casper; Guimaraes, Rui; Mayer, Igor S.; Bidarra, Rafael

2010-01-01

Most serious games have been developed without a proper and comprehensive design theory. To contribute to the development of such a theory, this article presents the underlying design philosophy of LEVEE PATROLLER, a game to train levee patrollers in the Netherlands. This philosophy stipulates that the design of a digital serious game is a…

33 CFR 100.40 - Patrol of the regatta or marine parade.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Patrol of the regatta or marine parade. 100.40 Section 100.40 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.40 Patrol of the regatta or...

A Practical Spanish Grammar for Border Patrol Officers.

ERIC Educational Resources Information Center

Border Patrol Academy, El Paso, TX.

Designed to be used in the Spanish training program for probationary officers at the Border Patrol Academy in El Paso, Texas, this revised 21-lesson traditional grammar text includes special features that make it pertinent to the job of a patrol inspector in the Mexican border area. An extensive appendix is comprised of exercise translations,…

Overexpression of SKI Oncoprotein Leads to p53 Degradation through Regulation of MDM2 Protein Sumoylation*

PubMed Central

Ding, Boxiao; Sun, Yin; Huang, Jiaoti

2012-01-01

Protooncogene Ski was identified based on its ability to transform avian fibroblasts in vitro. In support of its oncogenic activity, SKI was found to be overexpressed in a variety of human cancers, although the exact molecular mechanism(s) responsible for its oncogenic activity is not fully understood. We found that SKI can negatively regulate p53 by decreasing its level through up-regulation of MDM2 activity, which is mediated by the ability of SKI to enhance sumoylation of MDM2. This stimulation of MDM2 sumoylation is accomplished through a direct interaction of SKI with SUMO-conjugating enzyme E2, Ubc9, resulting in enhanced thioester bond formation and mono-sumoylation of Ubc9. A mutant SKI defective in transformation fails to increase p53 ubiquitination and is unable to increase MDM2 levels and to increase mono-sumoylation of Ubc9, suggesting that the ability of SKI to enhance Ubc9 activity is essential for its transforming function. These results established a detailed molecular mechanism that underlies the ability of SKI to cause cellular transformation while unraveling a novel connection between sumoylation and tumorigenesis, providing potential new therapeutic targets for cancer. PMID:22411991

The Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Transforming Growth Factor-β Signaling by Destabilizing Ski and Inducing Smad7*

PubMed Central

Band, Arja M.; Björklund, Mia; Laiho, Marikki

2009-01-01

Ski is an oncoprotein that negatively regulates transforming growth factor (TGF)-β signaling. It acts as a transcriptional co-repressor by binding to TGF-β signaling molecules, Smads. Efficient TGF-β signaling is facilitated by rapid proteasome-mediated degradation of Ski by TGF-β. Here we report that Ski is phosphorylated by Akt/PKB kinase. Akt phosphorylates Ski on a highly conserved Akt motif at threonine 458 both in vitro and in vivo. The phosphorylation of Ski at threonine 458 is induced by Akt pathway activators including insulin, insulin-like growth factor-1, and hepatocyte growth factor. The phosphorylation of Ski causes its destabilization and reduces Ski-mediated inhibition of expression of another negative regulator of TGF-β, Smad7. Induction of Smad7 levels leads to inactivation of TGF-β receptors and TGF-β signaling cascade, as indicated by reduced induction of TGF-β target p15. Therefore, Akt modulates TGF-β signaling by temporarily adjusting the levels of two TGF-β pathway negative regulators, Ski and Smad7. These novel findings demonstrate that Akt pathway activation directly impacts TGF-β pathway. PMID:19875456

Motor abilities and anthropometrics in youth cross-country skiing.

PubMed

Stöggl, R; Müller, E; Stöggl, T

2015-02-01

The purposes were to validate whether general motor abilities and anthropometrics are determinants of youth cross-country (XC) skiing performance; evaluate gender-specific differences; and to establish noninvasive diagnostics. Fifty-one youth XC skiers (34 boys; 13.8 ± 0.6 years and 17 girls; 13.4 ± 0.9 years) performed motor skill and laboratory tests, and anthropometric data were collected and correlated with XC skiing performance. Anthropometrics and maturity status were related to boys but not to girls XC skiing performance. Push-ups and 20-m sprint were correlated to XC skiing performance in both boys and girls. XC skiing performance of boys was predominantly influenced by upper body and trunk strength capacities (medicine ball throw, push-ups, and pull-ups) and jumping power (standing long and triple jump), whereas XC skiing of girls was mainly influenced by aerobic capacities (3000-m run). Laboratory measures did not reveal greater correlations to XC skiing performance compared with simple test concepts of speed, strength, and endurance. Maturity was a major confounding variable in boys but not girls. Use of noninvasive simple test concepts for determination of upper body strength, speed, and endurance represent practicable support for ski clubs, schools, or skiing federations in the guidance and evaluation of young talent, being aware of the effect of maturity especially in boys. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.

PubMed

Kiyono, Kunihiko; Suzuki, Hiroshi I; Morishita, Yasuyuki; Komuro, Akiyoshi; Iwata, Caname; Yashiro, Masakazu; Hirakawa, Kosei; Kano, Mitsunobu R; Miyazono, Kohei

2009-10-01

c-Ski, originally identified as a proto-oncogene product, is an important negative regulator of transforming growth factor (TGF)-beta family signaling through interaction with Smad2, Smad3, and Smad4. High expression of c-Ski has been found in some cancers, including gastric cancer. We previously showed that disruption of TGF-beta signaling by dominant-negative TGF-beta type II receptor in a diffuse-type gastric carcinoma model accelerated tumor growth through induction of tumor angiogenesis by decreased expression of the anti-angiogenic factor thrombospondin (TSP)-1. Here, we examined the function of c-Ski in human diffuse-type gastric carcinoma OCUM-2MLN cells. Overexpression of c-Ski inhibited TGF-beta signaling in OCUM-2MLN cells. Interestingly, c-Ski overexpression resulted in extensive acceleration of the growth of subcutaneous xenografts in BALB/c nu/nu female mice (6 weeks of age). Similar to tumors expressing dominant-negative TGF-beta type II receptor, histochemical studies revealed less fibrosis and increased angiogenesis in xenografted tumors expressing c-Ski compared to control tumors. Induction of TSP-1 mRNA by TGF-beta was attenuated by c-Ski in vitro, and expression of TSP-1 mRNA was decreased in tumors expressing c-Ski in vivo. These findings suggest that c-Ski overexpression promotes the growth of diffuse-type gastric carcinoma through induction of angiogenesis.

Ski and SnoN, potent negative regulators of TGF-β signaling

PubMed Central

Deheuninck, Julien; Luo, Kunxin

2011-01-01

Ski and the closely related SnoN were discovered as oncogenes by their ability to transform chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and SnoN have also been reported in many human cancer cells and tissues, consistent with their pro-oncogenic activity, emerging evidence also suggests a potential anti-oncogenic activity for both. In addition, Ski and SnoN have been implicated in regulation of cell differentiation, especially in the muscle and neuronal lineages. Multiple cellular partners of Ski and SnoN have been identified in an effort to understand the molecular mechanisms underlying the complex roles of Ski and SnoN. In this review, we summarize recent findings on the biological functions of Ski and SnoN, their mechanisms of action and how their levels of expression are regulated. PMID:19114989

78 FR 21343 - New Ski Area Water Rights Clause

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... DEPARTMENT OF AGRICULTURE Forest Service New Ski Area Water Rights Clause AGENCY: Forest Service... initial public input on a new water rights clause for ski area permits issued by the Forest Service. There... comments and suggestions that the Forest Service will consider in developing a new ski area water rights...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

Barriers and Enablers to Enacting Child and Youth Related Injury Prevention Legislation in Canada

PubMed Central

Rothman, Linda; Pike, Ian; Belton, Kathy; Olsen, Lise; Fuselli, Pam; Macpherson, Alison

2016-01-01

Injury prevention policy is crucial for the safety of Canada’s children; however legislation is not adopted uniformly across the country. This study aimed to identify key barriers and enablers to enacting injury prevention legislation. Purposive snowball sampling identified individuals involved in injury prevention throughout Canada. An online survey asked respondents to identify policies that were relevant to them, and whether legislation existed in their province. Respondents rated the importance of barriers or enablers using a 5-point Likert type scale and included open-ended comments. Fifty-seven respondents identified the most common injury topics: bicycle helmets (44, 77%), cell phone-distracted driving (36, 63%), booster seats (28, 49%), ski helmets (24, 42%), and graduated driver’s licensing (21, 37%). The top enablers were research/surveillance, managerial/political support and professional group consultation, with much variability between injury topics. Open-ended comments emphasized the importance of a united opinion as an enabler and barriers included costs of protective equipment and inadequate enforcement of legislation. The results highlighted the importance of strategies that include research, management and community collaboration and that injury prevention topics should be addressed individually as information may be lost if topics are considered together. Findings can inform the process of turning injury prevention evidence into action. PMID:27399745

Medical Care Before and During the Winter Paralympic Games in Turin 2006, Vancouver 2010 and Sochi 2014.

PubMed

Gawroński, Wojciech; Sobiecka, Joanna

2015-11-22

Medical care in disabled sports is crucial both as prophylaxis and as ongoing medical intervention. The aim of this paper was to present changes in the quality of medical care over the consecutive Paralympic Games (PG). The study encompassed 31 paralympians: Turin (11), Vancouver (12), and Sochi (8) competing in cross-country skiing, alpine skiing, biathlon and snowboarding. The first, questionnaire-based, part of the study was conducted in Poland before the PG. The athletes assessed the quality of care provided by physicians, physiologists, dieticians, and physiotherapists, as well as their cooperation with the massage therapist and the psychologist. The other part of the study concerned the athletes' health before leaving for the PG, as well as their diseases and injuries during the PG. The quality of medical care was poor before the 2006 PG, but satisfactory before the subsequent PG. Only few athletes made use of psychological support, assessing it as poor before the 2006 PG and satisfactory before the 2010 and 2014 PG. The athletes' health condition was good during all PG. The health status of cross-country skiers was confirmed by a medical fitness certificate before all PG, while that of alpine skiers only before the 2014 PG. There were no serious diseases; training injuries precluded two athletes from participation. The quality of medical care before the PG was poor, however, became satisfactory during the actual PG. The resulting ad hoc pattern deviates from the accepted standards in medical care in disabled sports.

Ski jump takeoff performance predictions for a mixed-flow, remote-lift STOVL aircraft

NASA Technical Reports Server (NTRS)

Birckelbaw, Lourdes G.

1992-01-01

A ski jump model was developed to predict ski jump takeoff performance for a short takeoff and vertical landing (STOVL) aircraft. The objective was to verify the model with results from a piloted simulation of a mixed flow, remote lift STOVL aircraft. The prediction model is discussed. The predicted results are compared with the piloted simulation results. The ski jump model can be utilized for basic research of other thrust vectoring STOVL aircraft performing a ski jump takeoff.

33 CFR 100.40 - Patrol of the regatta or marine parade.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Patrol of the regatta or marine... SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.40 Patrol of the regatta or marine parade. (a) The Commander of a Coast Guard District in which a regatta or marine parade is to be...

33 CFR 100.40 - Patrol of the regatta or marine parade.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Patrol of the regatta or marine... SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.40 Patrol of the regatta or marine parade. (a) The Commander of a Coast Guard District in which a regatta or marine parade is to be...

Coast Guard Cutter Procurement: Background and Issues for Congress

DTIC Science & Technology

2016-04-04

and 58 Fast Response Cutters (FRCs) as replacements for 90 aging Coast Guard cutters and patrol craft. The Coast Guard’s proposed FY2017 budget...Offshore Patrol Cutter (Generic Conceptual Rendering) ................................................. 5 Figure 3. Fast Response Cutter...National Security Cutters (NSCs), 25 Offshore Patrol Cutters (OPCs), and 58 Fast Response Cutters (FRCs). These 91 planned cutters are intended as

GATEWAY Demonstrations: Trial Demonstration of Area Lighting Retrofit, Yuma Border Patrol, Yuma, Arizona

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkerson, A. M.; McCullough, J. J.

Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments.

Cell Damage, Antioxidant Status, and Cortisol Levels Related to Nutrition in Ski Mountaineering During a Two-Day Race

PubMed Central

Diaz, Elena; Ruiz, Fatima; Hoyos, Itziar; Zubero, Jaime; Gravina, Leyre; Gil, Javier; Irazusta, Jon; Gil, Susana Maria

2010-01-01

The aim of this study was to measure the effect of nutrition on cell damage, antioxidant enzymes, and cortisol during a two-day ski mountaineering competition. Twenty-one male skiers participated in the study. Creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH), alkaline phosphatase (AP), cortisol and C-reactive protein (CRP), glutathione peroxidase (GPx) and reductase activities (GR) and C-reactive protein (CRP) levels, total antioxidant status, and cortisol levels were measured in serum the day before and immediately after the race. Their diet was also analysed during the competition. Enzymes and cortisol levels significantly increased after the competition. CK and LDH and cortisol levels were negatively correlated to total energy, protein, and fat intake. Intake of vitamin A, B1, B2, B6 and niacin was negatively correlated to LDH and AP. A negative correlation was also found between CK activity and Na, Fe, and Zn intake. Cortisol levels were negatively correlated to the intake of vitamins C, B1 and B2, and niacin. A positive correlation was found between serum GPx and intake of energy, carbohydrates, proteins, A and B vitamins, and folic acid. Skiers with the lowest nutrient intake during the competition were the ones who showed greater cell damage and lower antioxidant enzyme activity and cortisol levels, which may impair performance and also cause injuries and accidents. Particularly, skiers should have high intakes of total energy, macronutrients, vitamins A and B, Na, Zn, and Fe in order to decrease the deleterious effect of strenuous exercise. Key points A two-day ski mountaineering race produced muscle cell damage and oxidative stress and an increase in cortisol levels. There was a marked insufficient intake of carbohydrates which has been shown to affect performance Those skiers with lowest nutrient intake showed greater cell damage, lower antioxidant activity and higher cortisol levels. Nutrition should be carefully monitored and assessed in order to minimize the mentioned blood changes to avoid fatigue, injuries and also accidents in this type of sport; particularly when skiers must carry their own food. PMID:24149705

Cross-Country Skiing Today.

ERIC Educational Resources Information Center

Caldwell, John

This book presents changes in cross country skiing which have taken place in the last several years and is directed toward both beginning and seasoned tour skiers. Discussed are the following topics: (1) the cross-country revolution (new fiberglass skis); (2) equipment (how to choose from the new waxless touring skis); (3) care of equipment; (4)…

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.

PubMed

Takeda, Masafumi; Mizuide, Masafumi; Oka, Masako; Watabe, Tetsuro; Inoue, Hirofumi; Suzuki, Hiroyuki; Fujita, Toshiro; Imamura, Takeshi; Miyazono, Kohei; Miyazawa, Keiji

2004-03-01

c-Ski is a transcriptional corepressor that interacts strongly with Smad2, Smad3, and Smad4 but only weakly with Smad1 and Smad5. Through binding to Smad proteins, c-Ski suppresses signaling of transforming growth factor-beta (TGF-beta) as well as bone morphogenetic proteins (BMPs). In the present study, we found that a mutant of c-Ski, termed c-Ski (ARPG) inhibited TGF-beta/activin signaling but not BMP signaling. Selectivity was confirmed in luciferase reporter assays and by determination of cellular responses in mammalian cells (BMP-induced osteoblastic differentiation of C2C12 cells and TGF-beta-induced epithelial-to-mesenchymal transdifferentiation of NMuMG cells) and Xenopus embryos. The ARPG mutant recruited histone deacetylases 1 (HDAC1) to the Smad3-Smad4 complex but not to the Smad1/5-Smad4 complex. c-Ski (ARPG) was unable to interact with Smad4, and the selective loss of suppression of BMP signaling by c-Ski (ARPG) was attributed to the lack of Smad4 binding. We also found that c-Ski interacted with Smad3 or Smad4 without disrupting Smad3-Smad4 heteromer formation. c-Ski (ARPG) would be useful for selectively suppressing TGF-beta/activin signaling.

Interaction with Smad4 Is Indispensable for Suppression of BMP Signaling by c-Ski

PubMed Central

Takeda, Masafumi; Mizuide, Masafumi; Oka, Masako; Watabe, Tetsuro; Inoue, Hirofumi; Suzuki, Hiroyuki; Fujita, Toshiro; Imamura, Takeshi; Miyazono, Kohei; Miyazawa, Keiji

2004-01-01

c-Ski is a transcriptional corepressor that interacts strongly with Smad2, Smad3, and Smad4 but only weakly with Smad1 and Smad5. Through binding to Smad proteins, c-Ski suppresses signaling of transforming growth factor-β (TGF-β) as well as bone morphogenetic proteins (BMPs). In the present study, we found that a mutant of c-Ski, termed c-Ski (ARPG) inhibited TGF-β/activin signaling but not BMP signaling. Selectivity was confirmed in luciferase reporter assays and by determination of cellular responses in mammalian cells (BMP-induced osteoblastic differentiation of C2C12 cells and TGF-β–induced epithelial-to-mesenchymal transdifferentiation of NMuMG cells) and Xenopus embryos. The ARPG mutant recruited histone deacetylases 1 (HDAC1) to the Smad3-Smad4 complex but not to the Smad1/5-Smad4 complex. c-Ski (ARPG) was unable to interact with Smad4, and the selective loss of suppression of BMP signaling by c-Ski (ARPG) was attributed to the lack of Smad4 binding. We also found that c-Ski interacted with Smad3 or Smad4 without disrupting Smad3-Smad4 heteromer formation. c-Ski (ARPG) would be useful for selectively suppressing TGF-β/activin signaling. PMID:14699069

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression

PubMed Central

Rashidian, Juliet; Le Scolan, Erwan; Ji, Xiaodan; Zhu, Qingwei; Mulvihill, Melinda M.; Nomura, Daniel; Luo, Kunxin

2015-01-01

Ski, the transforming protein of the avian Sloan-Kettering retrovirus, inhibits transforming growth factor–β (TGF-β)/Smad signaling and displays both pro-oncogenic and anti-oncogenic activities in human cancer. Inhibition of TGF-β signaling is likely responsible for the pro-oncogenic activity of Ski. We investigated the mechanism(s) underlying the tumor suppressor activity of Ski and found that Ski suppressed the activity of the Hippo signaling effectors TAZ and YAP to inhibit breast cancer progression. TAZ and YAP are transcriptional coactivators that can contribute to cancer by promoting proliferation, tumorigenesis, and cancer stem cell expansion. Hippo signaling activates the the Lats family of kinases, which phosphorylate TAZ and YAP, resulting in cytoplasmic retention and degradation and inhibition of their transcriptional activity. We showed that Ski interacted with multiple components of the Hippo pathway to facilitate activation of Lats2, resulting in increased phosphorylation and subsequent degradation of TAZ. Ski also promoted the degradation of a constitutively active TAZ mutant that is not phosphorylated by Lats, suggesting the existence of a Lats2-independent degradation pathway. Finally, we showed that Ski repressed the transcriptional activity of TAZ by binding to the TAZ partner TEAD and recruiting the transcriptional co-repressor NCoR1 to the TEAD-TAZ complex. Ski effectively reversed transformation and epithelial-to-mesenchyme transition in cultured breast cancer cells and metastasis in TAZ-expressing xenografted tumors. Thus, Ski inhibited the function of TAZ through multiple mechanisms in human cancer cells. PMID:25670202

The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins.

PubMed

He, Jun; Tegen, Sarah B; Krawitz, Ariel R; Martin, G Steven; Luo, Kunxin

2003-08-15

The regulation of cell growth and differentiation by transforming growth factor-beta (TGF-beta) is mediated by the Smad proteins. In the nucleus, the Smad proteins are negatively regulated by two closely related nuclear proto-oncoproteins, Ski and SnoN. When overexpressed, Ski and SnoN induce oncogenic transformation of chicken embryo fibroblasts. However, the mechanism of transformation by Ski and SnoN has not been defined. We have previously reported that Ski and SnoN interact directly with Smad2, Smad3, and Smad4 and repress their ability to activate TGF-beta target genes through multiple mechanisms. Because Smad proteins are tumor suppressors, we hypothesized that the ability of Ski and SnoN to inactivate Smad function may be responsible for their transforming activity. Here, we show that the receptor regulated Smad proteins (Smad2 and Smad3) and common mediator Smad (Smad4) bind to different regions in Ski and SnoN. Mutation of both regions, but not each region alone, markedly impaired the ability of Ski and SnoN to repress TGF-beta-induced transcriptional activation and cell cycle arrest. Moreover, when expressed in chicken embryo fibroblasts, mutant Ski or SnoN defective in binding to the Smad proteins failed to induce oncogenic transformation. These results suggest that the ability of Ski and SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity. This may account for the resistance to TGF-beta-induced growth arrest in some human cancer cell lines that express high levels of Ski or SnoN.

Differential role of Sloan–Kettering Institute (Ski) protein in Nodal and transforming growth factor-beta (TGF-β)-induced Smad signaling in prostate cancer cells

PubMed Central

Khan, Shafiq A.

2012-01-01

Transforming growth factor-beta (TGF-β) signaling pathways contain both tumor suppressor and tumor promoting activities. We have demonstrated that Nodal, another member of the TGF-β superfamily, and its receptors are expressed in prostate cancer cells. Nodal and TGF-β exerted similar biological effects on prostate cells; both inhibited proliferation in WPE, RWPE1 and DU145 cells, whereas neither had any effect on the proliferation of LNCaP or PC3 cells. Interestingly, Nodal and TGF-β induced migration in PC3 cells, but not in DU145 cells. TGF-β induced predominantly phosphorylation of Smad3, whereas Nodal induced phosphorylation of only Smad2. We also determined the expression and differential role of Ski, a corepressor of Smad2/3, in Nodal and TGF-β signaling in prostate cancer cells. Similar levels of Ski mRNA were found in several established prostate cell lines; however, high levels of Ski protein were only detected in prostate cancer cells and prostate cancer tissue samples. Exogenous Nodal and TGF-β had no effects on Ski mRNA levels. On the other hand, TGF-β induced a rapid degradation of Ski protein mediated by the proteasomal pathway, whereas Nodal had no effect on Ski protein. Reduced Ski levels correlated with increased basal and TGF-β-induced Smad2/3 phosphorylation. Knockdown of endogenous Ski reduced proliferation in DU145 cells and enhanced migration of PC3 cells. We conclude that high levels of Ski expression in prostate cancer cells may be responsible for repression of TGF-β and Smad3 signaling, but Ski protein levels do not influence Nodal and Smad2 signaling. PMID:22843506

Ski Inhibits TGF-β/phospho-Smad3 Signaling and Accelerates Hypertrophic Differentiation in Chondrocytes

PubMed Central

Kim, Kyung-Ok; Sampson, Erik R.; Maynard, Robert D; O'Keefe, Regis J.; Chen, Di; Drissi, Hicham; Rosier, Randy N.; Hilton, Matthew J.; Zuscik, Michael J.

2012-01-01

Since TGF-β/Smad signaling inhibits chondrocyte maturation, endogenous negative regulators of TGF-β signaling are likely also important regulators of the chondrocyte differentiation process. One such negative regulator, Ski, is an oncoprotein that is known to inhibit TGF-β/Smad3 signaling via its interaction with phospho-Smad3 and recruitment of histone deacetylases (HDACs) to the DNA binding complex. Based on this, we hypothesized that Ski inhibits TGF-β signaling and accelerates maturation in chondrocytes via recruitment of HDACs to transcriptional complexes containing Smads. We tested this hypothesis in chick upper sternal chondrocytes (USCs), where gain and loss of Ski expression experiments were performed. Over-expression of Ski not only reversed the inhibitory effect of TGF-β on the expression of hypertrophic marker genes such as type × collagen (colX) and osteocalcin, it induced these genes basally as well. Conversely, knockdown of Ski by RNA interference led to a reduction of colX and osteocalcin expression under basal conditions. Furthermore, Ski blocked TGF-β induction of cyclinD1 and caused a basal up-regulation of Runx2, consistent with the observed acceleration of hypertrophy. Regarding mechanism, not only does Ski associate with phospho-Smad2 and 3, but its association with phospho-Smad3 is required for recruitment of HDAC4 and 5. Implicating this recruitment of HDACs in the phenotypic effects of Ski in chondrocytes, the HDAC inhibitor SAHA reversed the up-regulation of colX and osteocalcin in Ski over-expressing cells. These results suggest that inhibition of TGF-β signaling by Ski, which involves its association with phospho-Smad3 and recruitment of HDAC4 and 5, leads to accelerated chondrocyte differentiation. PMID:22461172

Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling.

PubMed

Chen, Weijun; Lam, Suvana S; Srinath, Hema; Schiffer, Celia A; Royer, William E; Lin, Kai

2007-04-13

The family of Smad proteins mediates transforming growth factor-beta (TGF-beta) signaling in cell growth and differentiation. Smads repress or activate TGF-beta signaling by interacting with corepressors (e.g. Ski) or coactivators (e.g. CREB-binding protein (CBP)), respectively. Specifically, Ski has been shown to interfere with the interaction between Smad3 and CBP. However, it is unclear whether Ski competes with CBP for binding to Smads and whether they can interact with Smad3 at the same binding surface on Smad3. We investigated the interactions among purified constructs of Smad, Ski, and CBP in vitro by size-exclusion chromatography, isothermal titration calorimetry, and mutational studies. Here, we show that Ski-(16-192) interacted directly with a homotrimer of receptor-regulated Smad protein (R-Smad), e.g. Smad2 or Smad3, to form a hexamer; Ski-(16-192) interacted with an R-Smad.Smad4 heterotrimer to form a pentamer. CBP-(1941-1992) was also found to interact directly with an R-Smad homotrimer to form a hexamer and with an R-Smad.Smad4 heterotrimer to form a pentamer. Moreover, these domains of Ski and CBP competed with each other for binding to Smad3. Our mutational studies revealed that domains of Ski and CBP interacted with Smad3 at a portion of the binding surface of the Smad anchor for receptor activation. Our results suggest that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes. Our working model suggests that Smad protein activity is delicately balanced by Ski and CBP in the TGF-beta pathway.

Snow management practices in French ski resorts

NASA Astrophysics Data System (ADS)

Spandre, Pierre; Francois, Hugues; George-Marcelpoil, Emmanuelle; Morin, Samuel

2016-04-01

Winter tourism plays a fundamental role in the economy of French mountain regions but also in other countries such as Austria, USA or Canada. Ski operators originally developed grooming methods to provide comfortable and safe skiing conditions. The interannual variability of snow conditions and the competition with international destinations and alternative tourism activities encouraged ski resorts to mitigate their dependency to weather conditions through snowmaking facilities. However some regions may not be able to produce machine made snow due to inadequate conditions and low altitude resorts are still negatively impacted by low snow seasons. In the meantime, even though the operations of high altitude resorts do not show any dependency to the snow conditions they invest in snowmaking facilities. Such developments of snowmaking facilities may be related to a confused and contradictory perception of climate change resulting in individualistic evolutions of snowmaking facilities, also depending on ski resorts main features such as their altitude and size. Concurrently with the expansion of snowmaking facilities, a large range of indicators have been used to discuss the vulnerability of ski resorts such as the so-called "100 days rule" which was widely used with specific thresholds (i.e. minimum snow depth, dates) and constraints (i.e. snowmaking capacity). The present study aims to provide a detailed description of snow management practices and major priorities in French ski resorts with respect to their characteristics. We set up a survey in autumn 2014, collecting data from 56 French ski operators. We identify the priorities of ski operators and describe their snowmaking and grooming practices and facilities. The operators also provided their perception of the ski resort vulnerability to snow and economic challenges which we could compare with the actual snow conditions and ski lift tickets sales during the period from 2001 to 2012.

Investigations on socio economic indicators of French Alps ski industry from an explicit spatial modelling of managed snow on ski slopes

NASA Astrophysics Data System (ADS)

Spandre, Pierre; François, Hugues; Morin, Samuel; George-Marcelpoil, Emmanuelle; Lafaysse, Matthieu

2017-04-01

Investigations of the capacity of ski resorts to anticipate, cope with and recover from the impact of natural snow scarcity through snow management (grooming, snowmaking) have been realized in most of the major regions in terms of international ski offer although not in the French Alps hitherto. The present work therefore introduces an innovative approach for the investigation of socio economic implications of changes in snow conditions for the French Alps ski resorts based on a panel of 129 resorts representing 96% of the total French Alps ski lifts infrastructures. We integrated detailed spatial representations of ski resorts (including priority areas for snowmaking equipment) along with physically based snowpack modelling (including the physical impact of grooming and snowmaking). The viability of ski resorts was further adressed thanks to a commonly used rule based on the snow season duration at the village and ski lifts average elevations along with the development of original viability indicators of snow conditions in the French Alps ski resorts based on the specific periods for the economic success of winter sports: Christmas and February school holidays. Such indicators were correlated to the number of ski lifts tickets sales over the 2001 - 2014 period and proved to be relevant to investigate and predict the evolutions of ski lifts tickets sales under the current ski market conditions in the French Alps. Our results outlined the contrast of snow conditions between French Alps ski resorts, even when accounting for snow management, particularly regarding the geographical location of resorts (Southern versus Northern Alps), the size and related elevation range of ski resorts. Our physically based approach also allowed to compute the water and energy requirements for the production of Machine Made snow since the start of the development of snowguns in the French Alps. Our computations proved to be strongly correlated to the observed amounts of water from the existing literature and confirmed that the increasing surface equipped with snowmaking facilities in the French Alps is the major factor for the increasing water and energy requirements since 1985. Such approach therefore provides objective information on the impact of snow conditions on the economic activity of winter sports in the French Alps under past and present conditions and may be considered as a relevant approach for further investigations, including the impact of climate change on the winter tourism in the French Alps.

Patrol force allocation for law enforcement: An introductory planning guide

NASA Technical Reports Server (NTRS)

Sohn, R. L.; Kennedy, R. D.

1976-01-01

Previous and current methods for analyzing police patrol forces are reviewed and discussed. The steps in developing an allocation analysis procedure are defined, including the prediction of the rate of calls for service, determination of the number of patrol units needed, designing sectors, and analyzing dispatch strategies. Existing computer programs used for this purpose are briefly described, and some results of their application are given.

Industry sources of trend data - skiing

Treesearch

William F., Jr. Malcolm

1980-01-01

With precious few exceptions, ski industry trend data does not exist. This paper will enumerate sources of trend data known to the author. The paper considers the probable causes of the lack of ski industry trend data and means to ameliorate the lack of trend data. Finally, the paper presents a rationale for acquiring improved ski industry trend data.

A Comparison of Work Health and Safety Incidents and Injuries in Part-Time and Full-Time Australian Army Personnel.

PubMed

McDonald, Dylan; Orr, Robin M; Pope, Rodney

2016-11-01

 Part-time personnel are an integral part of the Australian Army. With operational deployments increasing, it is essential that medical teams identify the patterns of injuries sustained by part-time personnel in order to mitigate the risks of injury and optimize deployability.  To compare the patterns of reported work health and safety incidents and injuries in part-time and full-time Australian Army personnel.  Retrospective cohort study.  The Australian Army.  Australian Army Reserve and Australian regular Army populations, July 1, 2012, through June 30, 2014.  Proportions of reported work health and safety incidents that resulted in injuries among Army Reserve and regular Army personnel and specifically the (a) body locations affected by incidents, (b) nature of resulting injuries, (c) injury mechanisms, and (d) activities being performed when the incidents occurred.  Over 2 years, 15 065 work health and safety incidents and 11 263 injuries were reported in Army Reserve and regular Army populations combined. In the Army Reserve population, 85% of reported incidents were classified as involving minor personal injuries; 4% involved a serious personal injury. In the regular Army population, 68% of reported incidents involved a minor personal injury; 5% involved a serious personal injury. Substantially lower proportions of Army reservist incidents involved sports, whereas substantially higher proportions were associated with combat training, manual handling, and patrolling when compared with regular Army incidents.  Army reservists had a higher proportion of injuries from Army work-related activities than did regular Army soldiers. Proportions of incidents arising from combat tasks and manual handling were higher in the Army Reserve. Understanding the sources of injuries will allow the medical teams to implement injury-mitigation strategies.

A Comparison of Work Health and Safety Incidents and Injuries in Part-Time and Full-Time Australian Army Personnel

PubMed Central

McDonald, Dylan; Orr, Robin M.; Pope, Rodney

2016-01-01

Context: Part-time personnel are an integral part of the Australian Army. With operational deployments increasing, it is essential that medical teams identify the patterns of injuries sustained by part-time personnel in order to mitigate the risks of injury and optimize deployability. Objective: To compare the patterns of reported work health and safety incidents and injuries in part-time and full-time Australian Army personnel. Design: Retrospective cohort study. Setting: The Australian Army. Patients or Other Participants: Australian Army Reserve and Australian regular Army populations, July 1, 2012, through June 30, 2014. Main Outcome Measure(s): Proportions of reported work health and safety incidents that resulted in injuries among Army Reserve and regular Army personnel and specifically the (a) body locations affected by incidents, (b) nature of resulting injuries, (c) injury mechanisms, and (d) activities being performed when the incidents occurred. Results: Over 2 years, 15 065 work health and safety incidents and 11 263 injuries were reported in Army Reserve and regular Army populations combined. In the Army Reserve population, 85% of reported incidents were classified as involving minor personal injuries; 4% involved a serious personal injury. In the regular Army population, 68% of reported incidents involved a minor personal injury; 5% involved a serious personal injury. Substantially lower proportions of Army reservist incidents involved sports, whereas substantially higher proportions were associated with combat training, manual handling, and patrolling when compared with regular Army incidents. Conclusions: Army reservists had a higher proportion of injuries from Army work-related activities than did regular Army soldiers. Proportions of incidents arising from combat tasks and manual handling were higher in the Army Reserve. Understanding the sources of injuries will allow the medical teams to implement injury-mitigation strategies. PMID:27710093

Decentralized Patrolling Under Constraints in Dynamic Environments.

PubMed

Shaofei Chen; Feng Wu; Lincheng Shen; Jing Chen; Ramchurn, Sarvapali D

2016-12-01

We investigate a decentralized patrolling problem for dynamic environments where information is distributed alongside threats. In this problem, agents obtain information at a location, but may suffer attacks from the threat at that location. In a decentralized fashion, each agent patrols in a designated area of the environment and interacts with a limited number of agents. Therefore, the goal of these agents is to coordinate to gather as much information as possible while limiting the damage incurred. Hence, we model this class of problem as a transition-decoupled partially observable Markov decision process with health constraints. Furthermore, we propose scalable decentralized online algorithms based on Monte Carlo tree search and a factored belief vector. We empirically evaluate our algorithms on decentralized patrolling problems and benchmark them against the state-of-the-art online planning solver. The results show that our approach outperforms the state-of-the-art by more than 56% for six agents patrolling problems and can scale up to 24 agents in reasonable time.

Multi-Agent Patrolling under Uncertainty and Threats.

PubMed

Chen, Shaofei; Wu, Feng; Shen, Lincheng; Chen, Jing; Ramchurn, Sarvapali D

2015-01-01

We investigate a multi-agent patrolling problem where information is distributed alongside threats in environments with uncertainties. Specifically, the information and threat at each location are independently modelled as multi-state Markov chains, whose states are not observed until the location is visited by an agent. While agents will obtain information at a location, they may also suffer damage from the threat at that location. Therefore, the goal of the agents is to gather as much information as possible while mitigating the damage incurred. To address this challenge, we formulate the single-agent patrolling problem as a Partially Observable Markov Decision Process (POMDP) and propose a computationally efficient algorithm to solve this model. Building upon this, to compute patrols for multiple agents, the single-agent algorithm is extended for each agent with the aim of maximising its marginal contribution to the team. We empirically evaluate our algorithm on problems of multi-agent patrolling and show that it outperforms a baseline algorithm up to 44% for 10 agents and by 21% for 15 agents in large domains.

Ecological Impacts of Revegetation and Management Practices of Ski Slopes in Northern Finland

NASA Astrophysics Data System (ADS)

Kangas, Katja; Tolvanen, Anne; Kälkäjä, Tarja; Siikamäki, Pirkko

2009-09-01

Outdoor recreation and nature-based tourism represent an increasingly intensive form of land use that has considerable impacts on native ecosystems. The aim of this paper is to investigate how revegetation and management of ski runs influence soil nutrients, vegetation characteristics, and the possible invasion of nonnative plant species used in revegetation into native ecosystems. A soil and vegetation survey at ski runs and nearby forests, and a factorial experiment simulating ski run construction and management (factors: soil removal, fertilization, and seed sowing) were conducted at Ruka ski resort, in northern Finland, during 2003-2008. According to the survey, management practices had caused considerable changes in the vegetation structure and increased soil nutrient concentrations, pH, and conductivity on the ski runs relative to nearby forests. Seed mixture species sown during the revegetation of ski runs had not spread to adjacent forests. The experimental study showed that the germination of seed mixture species was favored by treatments simulating the management of ski runs, but none of them could eventually establish in the study forest. As nutrient leaching causes both environmental deterioration and changes in vegetation structure, it may eventually pose a greater environmental risk than the spread of seed mixture species alone. Machine grading and fertilization, which have the most drastic effects on soils and vegetation, should, therefore, be minimized when constructing and managing ski runs.

Ecological impacts of revegetation and management practices of ski slopes in northern Finland.

PubMed

Kangas, Katja; Tolvanen, Anne; Kälkäjä, Tarja; Siikamäki, Pirkko

2009-09-01

Outdoor recreation and nature-based tourism represent an increasingly intensive form of land use that has considerable impacts on native ecosystems. The aim of this paper is to investigate how revegetation and management of ski runs influence soil nutrients, vegetation characteristics, and the possible invasion of nonnative plant species used in revegetation into native ecosystems. A soil and vegetation survey at ski runs and nearby forests, and a factorial experiment simulating ski run construction and management (factors: soil removal, fertilization, and seed sowing) were conducted at Ruka ski resort, in northern Finland, during 2003-2008. According to the survey, management practices had caused considerable changes in the vegetation structure and increased soil nutrient concentrations, pH, and conductivity on the ski runs relative to nearby forests. Seed mixture species sown during the revegetation of ski runs had not spread to adjacent forests. The experimental study showed that the germination of seed mixture species was favored by treatments simulating the management of ski runs, but none of them could eventually establish in the study forest. As nutrient leaching causes both environmental deterioration and changes in vegetation structure, it may eventually pose a greater environmental risk than the spread of seed mixture species alone. Machine grading and fertilization, which have the most drastic effects on soils and vegetation, should, therefore, be minimized when constructing and managing ski runs.

Global information sampling in the honey bee

NASA Astrophysics Data System (ADS)

Johnson, Brian R.

2008-06-01

Central to the question of task allocation in social insects is how workers acquire information. Patrolling is a curious behavior in which bees meander over the face of the comb inspecting cells. Several authors have suggested it allows bees to collect global information, but this has never been formally evaluated. This study explores this hypothesis by answering three questions. First, do bees gather information in a consistent manner as they patrol? Second, do they move far enough to get a sense of task demand in distant areas of the nest? And third, is patrolling a commonly performed task? Focal animal observations were used to address the first two predictions, while a scan sampling study was used to address the third. The results were affirmative for each question. While patrolling, workers collected information by performing periodic clusters of cell inspections. Patrolling bees not only traveled far enough to frequently change work zone; they often visited every part of the nest. Finally, the majority of the bees in the middle-age caste were shown to move throughout the nest over the course of a few hours in a manner suggestive of patrolling. Global information collection is contrary to much current theory, which assumes that workers respond to local information only. This study thus highlights the nonmutually exclusive nature of various information collection regimes in social insects.

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.

PubMed

Singbrant, Sofie; Wall, Meaghan; Moody, Jennifer; Karlsson, Göran; Chalk, Alistair M; Liddicoat, Brian; Russell, Megan R; Walkley, Carl R; Karlsson, Stefan

2014-04-01

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compartments, and a marked enhancement of myeloid differentiation at the expense of other lineages. Accordingly, enforced expression of SKI induced a gene signature associated with hematopoietic stem cells and myeloid differentiation, as well as hepatocyte growth factor signaling. Here we demonstrate that, in contrast to what has generally been assumed, the significant impact of SKI on hematopoiesis is independent of its ability to inhibit TGF-beta signaling. Instead, myeloid progenitors expressing SKI are partially dependent on functional hepatocyte growth factor signaling. Collectively our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease.

Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition.

PubMed

Tessé, Sophie; Storlazzi, Aurora; Kleckner, Nancy; Gargano, Silvana; Zickler, Denise

2003-10-28

Ski8p is implicated in degradation of non-poly(A) and double-stranded RNA, and in meiotic DNA recombination. We have identified the Sordaria macrospora SKI8 gene. Ski8p is cytoplasmically localized in all vegetative and sexual cycle cells, and is nuclear localized, specifically in early-mid-meiotic prophase, in temporal correlation with Spo11p, the meiotic double-strand break (DSB) transesterase. Localizations of Ski8p and Spo11p are mutually interdependent. ski8 mutants exhibit defects in vegetative growth, entry into the sexual program, and sporulation. Diverse meiotic defects, also seen in spo11 mutants, are diagnostic of DSB absence, and they are restored by exogenous DSBs. These results suggest that Ski8p promotes meiotic DSB formation by acting directly within meiotic prophase chromosomes. Mutant phenotypes also divide meiotic homolog juxtaposition into three successive, mechanistically distinct steps; recognition, presynaptic alignment, and synapsis, which are distinguished by their differential dependence on DSBs.

Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition

PubMed Central

Tessé, Sophie; Storlazzi, Aurora; Kleckner, Nancy; Gargano, Silvana; Zickler, Denise

2003-01-01

Ski8p is implicated in degradation of non-poly(A) and double-stranded RNA, and in meiotic DNA recombination. We have identified the Sordaria macrospora SKI8 gene. Ski8p is cytoplasmically localized in all vegetative and sexual cycle cells, and is nuclear localized, specifically in early-mid-meiotic prophase, in temporal correlation with Spo11p, the meiotic double-strand break (DSB) transesterase. Localizations of Ski8p and Spo11p are mutually interdependent. ski8 mutants exhibit defects in vegetative growth, entry into the sexual program, and sporulation. Diverse meiotic defects, also seen in spo11 mutants, are diagnostic of DSB absence, and they are restored by exogenous DSBs. These results suggest that Ski8p promotes meiotic DSB formation by acting directly within meiotic prophase chromosomes. Mutant phenotypes also divide meiotic homolog juxtaposition into three successive, mechanistically distinct steps; recognition, presynaptic alignment, and synapsis, which are distinguished by their differential dependence on DSBs. PMID:14563920

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease

PubMed Central

Singbrant, Sofie; Wall, Meaghan; Moody, Jennifer; Karlsson, Göran; Chalk, Alistair M.; Liddicoat, Brian; Russell, Megan R.; Walkley, Carl R.; Karlsson, Stefan

2014-01-01

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compartments, and a marked enhancement of myeloid differentiation at the expense of other lineages. Accordingly, enforced expression of SKI induced a gene signature associated with hematopoietic stem cells and myeloid differentiation, as well as hepatocyte growth factor signaling. Here we demonstrate that, in contrast to what has generally been assumed, the significant impact of SKI on hematopoiesis is independent of its ability to inhibit TGF-beta signaling. Instead, myeloid progenitors expressing SKI are partially dependent on functional hepatocyte growth factor signaling. Collectively our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease. PMID:24415629

Pedestrian injuries resulting from road traffic accidents: the Azare experience.

PubMed

Umaru, H; Ahidjo, A; Dogo, H

2007-01-01

Road traffic accident (RTA) is a leading cause of serious morbidity and mortality world wide. The pedestrians are not spared from this epidemic. The aim of this study is to identify factors that puts the pedestrian at risk of injuries from RTA and the anatomical regions most commonly involved in our environment and suggest ways of curbing them. This was a one-year retrospective study of 122 pedestrian casualties resulting from road traffic accident attending the Accident and Emergency (A/E) Unit of the Federal Medical Centre, Azare. Majority of the patients (72%) were males with a male to female ratio of 2.6:1. Children and adolescents constitute 54.1% of the casualties. Motorcycles were responsible for most of the pedestrian injuries (73%). The head and neck was the most frequently injured anatomical region of the body (43.4%), followed by the extremities (37%). The months of August and January were the peak periods of injuries. The safety of pedestrian is seriously threatened by the growing popularity of commercial motorcycles on our roads. Preventive measures are advocated to ensure only licensed cyclists are allowed on the roads. Adequate personnel training to manage head injury in our centers is also advised. More patrol by the road safety agents is advised in the months of January and August.

Physiological Responses of Elderly Recreational Alpine Skiers of Different Fitness and Skiing Abilities

PubMed Central

Krautgasser, Sabine; Scheiber, Peter; von Duvillard, Serge P.; Müller, Erich

2011-01-01

We measured physiological responses of elderly recreational skiers of different fitness and skiing abilities. Six subjects (mean age: 61.2 ± 4.6 yrs; Wt: 76.8 ± 15.6 kg; Ht: 1.69 ± 0.10 m; BMI: 26.9 ± 5.0) were tested in a laboratory and during 30 and 75 min of recreational downhill skiing. Oxygen uptake (VO2), heart rate (HR), blood lactate (LA) concentration, and diastolic (DBP) and systolic (SBP) blood pressure were used to estimate energy demands while skiing. During maximal testing in a laboratory, subjects achieved a mean maximal VO2max of 28.2 ± 7.5 ml.kg-1.min-1 and a mean HRpeak of 165 ± 4 bpm (98 ± 1% of HRmax). Mean maximal workload measured on a cycle ergometer was 2.2 ± 0.7 W.kg-1 with a mean LApeak of 7.4 ± 1 mmol.l-1. During field testing, mean VO2 during skiing was 12 ± 2 ml.kg-1.min-1 (45 ± 16% of VO2max). Skiing VO2peak was 19 ± 5 ml. kg-1.min-1 (72 ± 23% of VO2max) was lower than VO2max in the lab (p = 0.04). Mean HR during skiing was 126 ± 2 bpm (77 ± 1% of HRmax from lab tests). Skiing HRpeak was 162 ± 2 bpm. This was not different from HRmax in the lab (p = 0.68). Mean LA after 30 and 75 min of skiing was not different (2.2 ± 0.8 mmol.l-1 and 2.0 ± 0.8, respectively, p = 0.71). Both LA samples during skiing were lower than lab tests (p < 0.0001). There was no difference for DBP between field and laboratory tests; however, SBP increased after 30 min of skiing to 171 ± 20 (p < 0.009) and 165 ± 17 (p < 0.003) after 75 min. These remained below the mean peak SBP determined in lab tests (218+31). Mean oxygen demand during 30 and 75 min of recreational skiing is only 45% of VO2max while mean HR is 77% of HRmax. This departure from linearity not often seen in typical aerobic activities suggests that alpine skiing requires a combination of aerobic and anaerobic activity. Blood LA remained low during skiing suggesting that elderly skiers may govern their intensity via signals closer to VO2 and LA compared to HR or BP. Key points Recreational Alpine skiing for elderly population does not pose health risks Blood pressure and heart rate during recreational Alpine skiing is retain within normal limits Blood lactate levels remain relatively low and do not contribute to fatigue Oxygen uptake and blood lactate are better markers of intensity in elderly Alpine skier compared to heart rate and blood pressure. PMID:24149569

Impact of climate change on the operation of ski slopes in South Korea

NASA Astrophysics Data System (ADS)

Kim, S.; Park, J. H.; Lee, D. K.

2017-12-01

The purpose of this study is to predict changes in the operation of ski slopes due to climate change and offer meaningful implications that the ski industry can refer to when preparing to address climate change. All 17 ski resorts in South Korea were selected as study sites. To determine the weather and managerial conditions for the operation of ski slopes, interviews with operators and a review of past weather and operational conditions were conducted. To project future changes in the season of operation for ski slopes, future weather data for the 2030s, 2060s, and 2090s from RCP scenarios were adapted to the conditions for the operation of ski slopes.The study found that the artificial snowmaking begins when the temperature reaches -2 °C, the slope is opened 9 days after artificial snowmaking starts, and the slope is closed when the temperature reaches 0 °C. By applying future weather data to these conditions, it is estimated that the ski season will decrease in the future as follows: from around 130 days at present to around 120 days based on RCP 2.0 and RCP 6.0, around 130 days based on RCP 4.5, and 90 days based on RCP 8.5 in the areas where the average temperature of the ski season is below -2 °C; from around 120 days at present to around 120 days based on RCP 2.0 and 4.5, around 100-days based on RCP 6.0, and 60 days based on RCP 8.5 in the areas where the average temperature of the ski season is below 0 °C; from around 90 days at present to around 80 days based on RCP 2.0, around 90 days based on RCP 4.5, around 50 days based on RCP 6.0, and 10 days based on RCP 8.5 in the areas where the average temperature of the ski season is above 0 °C. In addition, it is also estimated that in the 2090s, 16 of 17 ski resorts can survive based on RCP 2.6 and RCP 4.5, 13 ski resorts can survive based on RCP 6.0, and none of the resorts can survive based on RCP 8.5, according to the 100-days rule, which is the minimum required duration of the operation of ski resorts. The results of this study show that there will be major changes in the ski industry due to climate change. It is expected that operators, who already invested massive budgets into the development of ski slopes, will experience difficulties in management due to the deterioration of destinations and the loss of skiers due to climate change. Thus, managerial strategies that helps operators flexibly respond to climate change are required.

Crossing physical simulations of snow conditions and a geographic model of ski area to assess ski resorts vulnerability

NASA Astrophysics Data System (ADS)

François, Hugues; Spandre, Pierre; Morin, Samuel; George-Marcelpoil, Emmanuelle; Lafaysse, Matthieu; Lejeune, Yves

2016-04-01

In order to face climate change, meteorological variability and the recurrent lack of natural snow on the ground, ski resorts adaptation often rely on technical responses. Indeed, since the occurrence of episodes with insufficient snowfalls in the early 1990's, snowmaking has become an ordinary practice of snow management, comparable to grooming, and contributes to optimise the operation of ski resorts. It also participates to the growth of investments and is associated with significant operating costs, and thus represents a new source of vulnerability. The assessment of the actual effects of snowmaking and of snow management practices in general is a real concern for the future of the ski industry. The principal model use to simulate snow conditions in resorts, Ski Sim, has also been moving this way. Its developers introduced an artificial input of snow on ski area to complete natural snowfalls and considered different organisations of ski lifts (lower and upper zones). However the use of a degree-day model prevents them to consider the specific properties of artificial snow and the impact of grooming on the snowpack. A first proof of concept in the French Alps has shown the feasibility and the interest to cross the geographic model of ski areas and the output of the physically-based reanalysis of snow conditions SAFRAN - Crocus (François et al., CRST 2014). Since these initial developments, several ways have been explored to refine our model. A new model of ski areas has been developed. Our representation is now based on gravity derived from a DEM and ski lift localisation. A survey about snow management practices also allowed us to define criteria in order to model snowmaking areas given ski areas properties and tourism infrastructures localisation. We also suggest to revisit the assessment of ski resort viability based on the "one hundred days rule" based on natural snow depth only. Indeed, the impact of snow management must be considered so as to propose reliability indices that are both physically and socio-economically meaningful. Our contribution proposes to present these works in the context of a test resort in the French Alps and its snow conditions during the period 2000-2012. In order to show the impact of different management practices three configurations are considered: natural snowfalls, groomed natural snowfalls and managed snow (natural and artificial snowpack combined with grooming) and discuss the implications of the results in terms of the assessment of the climate vulnerability of ski resorts.

Border Injuries: An Analysis of Prehospital Demographics, Mechanisms, and Patterns of Injuries Encountered by USBP EMS Agents in the El Paso (Texas USA) Sector.

PubMed

Baker, Russell A

2017-08-01

Study Objective The aim of this study was to evaluate Emergency Medical Services (EMS), use, injury mechanisms, prehospital assessments, and injuries among those receiving aid from the United States Border Patrol (USBP) in the El Paso (Texas USA) Sector. This is a time-series, retrospective analysis of all prehospital data for injuries among patients receiving care from USBP EMS on the US Mexico border in the El Paso sector from February 6, 2014 to February 6, 2016. A total of 473 documented EMS encounters occurred in this two-year period and demonstrated a male gender predominance (male 63%; female 37%) with the most prominent ages between 22-40 years old. The most prevalent EMS call types were medical (55%) and trauma (42%). The most common chief complaints were an injured or painful extremity (35%) and rash (13%). The most common USBP EMS provider primary impression was traumatic injury (34%), followed by fever/infection (17%) and extremity injury (7%); however, the most common secondary impression was also extremity injury (20%). The most common mechanism of injury was fall (26%) and motor vehicle accident (MVA; 22%). The USBP EMS was the first provider on scene in 96% of the MVAs. The author reports on injury patterns, mechanisms, chief complaints, EMS impressions, as well as demographics of patients reporting to USBP EMS. A knowledge of these injury patterns will be useful to EMS administrators and physicians along the US Mexico border. Baker RA . Border injuries: an analysis of prehospital demographics, mechanisms, and patterns of injuries encountered by USBP EMS agents in the El Paso (Texas USA) Sector. Prehosp Disaster Med. 2017;32(4):431-436.

Determinants of a simulated cross-country skiing sprint competition using V2 skating technique on roller skis.

PubMed

Mikkola, Jussi; Laaksonen, Marko; Holmberg, Hans-Christer; Vesterinen, Ville; Nummela, Ari

2010-04-01

The present study investigated the performance-predicting factors of a simulated cross-country (XC) skiing sprint competition on roller skis, on a slow surface. Sixteen elite male XC skiers performed a simulated sprint competition (4 x 850 m heat with a 20-minute recovery) using V2 skating technique on an indoor tartan track. Heat velocities, oxygen consumption, and peak lactate were measured during or after the heats. Maximal skiing velocity was measured by performing a 30-m speed test. Explosive and maximal force production in the upper body was determined by bench press (BP). Subjects also performed maximal anaerobic skiing test (MAST) and the 2 x 2-km double poling (DP) test. The maximal velocity of MAST (VMAST) and velocities at 3 (V3), 5 (V5), 7 (V7) mmol.L lactate levels in MAST were determined. In the 2 x 2-km test, DP economy (VO2SUBDP) and maximal 2-km DP velocity (VDP2KM) were determined. The best single performance-predicting factors for the sprint performance were VDP2KM (r = 0.73, p < 0.01), V7 (r = 0.70, p < 0.01), and VO2SUBDP (r = -0.70, p < 0.01). Faster skiers in sprint simulation had a higher absolute VO2 (L.min) (p < 0.05-0.01) during sprint heats, and higher anaerobic skiing power (VMAST, p < 0.05) and better anaerobic skiing economy (V3, V5, V7, p < 0.05-0.001) than slower skiers. Faster skiers were also stronger in BP, with regard to both absolute (p < 0.01) and relative (p < 0.05) values. In addition, anaerobic characteristics seem to be of importance at the beginning of the XC skiing sprint competition, whereas the aerobic characteristics become more important as the XC skiing sprint competition progressed. This study indicates that sprint skiers should emphasize sport-specific upper body training, and training skiing economy at high speeds.

Modelling technical snow production for skiing areas in the Austrian Alps with the physically based snow model AMUNDSEN

NASA Astrophysics Data System (ADS)

Hanzer, F.; Marke, T.; Steiger, R.; Strasser, U.

2012-04-01

Tourism and particularly winter tourism is a key factor for the Austrian economy. Judging from currently available climate simulations, the Austrian Alps show a particularly high vulnerability to climatic changes. To reduce the exposure of ski areas towards changes in natural snow conditions as well as to generally enhance snow conditions at skiing sites, technical snowmaking is widely utilized across Austrian ski areas. While such measures result in better snow conditions at the skiing sites and are important for the local skiing industry, its economic efficiency has also to be taken into account. The current work emerges from the project CC-Snow II, where improved future climate scenario simulations are used to determine future natural and artificial snow conditions and their effects on tourism and economy in the Austrian Alps. In a first step, a simple technical snowmaking approach is incorporated into the process based snow model AMUNDSEN, which operates at a spatial resolution of 10-50 m and a temporal resolution of 1-3 hours. Locations of skiing slopes within a ski area in Styria, Austria, were digitized and imported into the model environment. During a predefined time frame in the beginning of the ski season, the model produces a maximum possible amount of technical snow and distributes the associated snow on the slopes, whereas afterwards, until to the end of the ski season, the model tries to maintain a certain snow depth threshold value on the slopes. Due to only few required input parameters, this approach is easily transferable to other ski areas. In our poster contribution, we present first results of this snowmaking approach and give an overview of the data and methodology applied. In a further step in CC-Snow, this simple bulk approach will be extended to consider actual snow cannon locations and technical specifications, which will allow a more detailed description of technical snow production as well as cannon-based recordings of water and energy consumption.

Security Games Involving Search and Patrolling

DTIC Science & Technology

2017-04-28

AFRL-AFOSR-UK-TR-2017-0032 Security Games Involving Search and Patrolling Steve Alpern UNIVERSITY OF WARWICK Final Report 04/28/2017 DISTRIBUTION A...From - To) 01 Feb 2014 to 31 Jan 2017 4. TITLE AND SUBTITLE Security Games Involving Search and Patrolling 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER...interview sequentially has been recently published. Work of Alpern and Howard (2016) solves a class of winner-take-all games which include the

U. S. Naval Forces, Vietnam Monthly Historical Supplement for December 1967

DTIC Science & Technology

1968-05-07

Coastal Surveillance Force 1 Operation MARKiiT TIME 1 MARKET TIME Unit 13 MARKET TIM£. Statistical Sunnary U Operation STABLE DOOR 16 River...Patrol Force 19 Rung Sfit Special Zone River Patrol Group 21 Delta Uiver Patrol Group 25 GAME WARDEN Unit 42 GAME WARDEN Statistical Sumnfixy 43...Bassac River Operations 38 GAME GARDEN Detections, Inspections, Boardings . . 44 TF 117 units land troops in the Delta 46 CAFT SALZiÄ relieves CAPT

Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression

PubMed Central

2011-01-01

Background SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN protein levels co-exist with active autocrine TGF-β signaling in cancer cells is yet to be understood. Results In this study, we found elevated SKI and SnoN protein levels in a panel of melanoma cell lines, as compared to normal melanocytes. There was no correlation between SKI protein content and the capacity of melanoma cells to invade Matrigel™, to form subcutaneous tumors, or to metastasize to bone after intracardiac inoculation into nude mice. Nor did we find a correlation between SKI expression and histopathological staging of human melanoma. TGF-β induced a rapid and dose-dependent degradation of SKI protein, associated with SMAD3/4 specific transcriptional response and induction of pro-metastatic target genes, partially prevented by pharmacologic blockade of proteasome activity. SKI knockdown in 1205Lu melanoma cells did not alter their invasive capacity or transcriptional responses to TGF-β, and did not allow p21 expression in response to TGF-β or reveal any growth inhibitory activity of TGF-β. Conclusions Despite high expression in melanoma cells, the role of SKI in melanoma remains elusive: SKI does not efficiently interfere with the pro-oncogenic activities of TGF-β, unless stabilized by proteasome blockade. Its highly labile nature makes it an unlikely target for therapeutic intervention. PMID:21211030

SKI knockdown inhibits human melanoma tumor growth in vivo.

PubMed

Chen, Dahu; Lin, Qiushi; Box, Neil; Roop, Dennis; Ishii, Shunsuke; Matsuzaki, Koichi; Fan, Tao; Hornyak, Thomas J; Reed, Jon A; Stavnezer, Ed; Timchenko, Nikolai A; Medrano, Estela E

2009-12-01

The SKI protein represses the TGF-beta tumor suppressor pathway by associating with the Smad transcription factors. SKI is upregulated in human malignant melanoma tumors in a disease-progression manner and its overexpression promotes proliferation and migration of melanoma cells in vitro. The mechanisms by which SKI antagonizes TGF-beta signaling in vivo have not been fully elucidated. Here we show that human melanoma cells in which endogenous SKI expression was knocked down by RNAi produced minimal orthotopic tumor xenograft nodules that displayed low mitotic rate and prominent apoptosis. These minute tumors exhibited critical signatures of active TGF-beta signaling including high levels of nuclear Smad3 and p21(Waf-1), which are not found in the parental melanomas. To understand how SKI promotes tumor growth we used gain- and loss-of-function approaches and found that simultaneously to blocking the TGF-beta-growth inhibitory pathway, SKI promotes the switch of Smad3 from tumor suppression to oncogenesis by favoring phosphorylations of the Smad3 linker region in melanoma cells but not in normal human melanocytes. In this context, SKI is required for preventing TGF-beta-mediated downregulation of the oncogenic protein c-MYC, and for inducing the plasminogen activator inhibitor-1, a mediator of tumor growth and angiogenesis. Together, the results indicate that SKI exploits multiple regulatory levels of the TGF-beta pathway and its deficiency restores TGF-beta tumor suppressor and apoptotic activities in spite of the likely presence of oncogenic mutations in melanoma tumors.

The epidemiology of sports-related injuries in older adults: a central European epidemiologic study.

PubMed

Kammerlander, Christian; Braito, Matthias; Kates, Stephen; Jeske, Christian; Roth, Tobias; Blauth, Michael; Dallapozza, Christian

2012-10-01

The population is rapidly aging and remaining more active over the age of 65. An increasing number of sports related injuries in individuals 65 and older are thus anticipated. The aim of this study is to analyze the epidemiology of sports injuries in the age group aged 65 and older. Data from the medical records of adults aged 65 years and older who were treated for sports-related injuries at a level one trauma center between December 1994 and February 2008 was collected and statistically analyzed. A total of 2635 patients met our inclusion criteria. There were 1647 men (62.5%) and 988 women (37.5%) with a mean age of 70.9 years. The yearly number of injuries doubled during the study period (1996-2007). The most common mechanism of injury was a simple fall from standing height (69%). Nearly 75% of all injuries occurred during alpine skiing, cycling or mountain climbing. The median Injury Severity Score was 4. Minor injuries and wounds (40%) were recorded most commonly followed by fractures (27%), sprains, ligament injuries (19%) and injuries of muscles and tendons (6%). The most frequent diagnoses were minor injuries to the head and ligament injuries around the knee joint. Injuries to the upper extremities occurred in 33.7%, injuries to the lower extremities in 29.4% and injuries to the head occurred in 20% of the patients. Women sustained substantially more fractures than men. Adults aged 65 and older are remaining active in sports, which results in higher numbers of sports related injuries in this age group. Identification of type, mechanism and distribution of the injuries can help with the recognition of risk factors for injury. This may enable us to develop appropriate preventative measures to reduce the incidence, and morbidity of such injuries.

Repression of endogenous Smad7 by Ski.

PubMed

Denissova, Natalia G; Liu, Fang

2004-07-02

The Ski protein has been proposed to serve as a corepressor for Smad4 to maintain a transforming growth factor-beta (TGF-beta)-responsive promoter at a repressed, basal level. However, there have been no reports so far that it indeed acts on a natural promoter. We have previously cloned the human Smad7 promoter and shown that it contains the 8-base pair palindromic Smad-binding element (SBE) necessary for TGF-beta induction. In this report, we have characterized the negative regulation of Smad7 promoter basal activity by Ski. We show that Ski inhibits the Smad7 promoter basal activity in a SBE-dependent manner. Mutation of the SBE abrogates the inhibitory effect of Ski on the Smad7 promoter. Moreover, mutation of the SBE increases the Smad7 promoter basal activity. Using the chromatin immunoprecipitation assay, we further show that Ski together with Smad4 binds to the endogenous Smad7 promoter. Finally, we show that RNAi knockdown of Ski increases Smad7 reporter gene activity in transient transfection assays as well as elevating the endogenous level of Smad7 mRNA. Taken together, our results provide the first evidence that Ski is indeed a corepressor for Smad4, which can inhibit a natural TGF-beta responsive gene at the basal state.

Translation of a Ski School Sun Safety Program to North American Ski and Snowboard Schools

PubMed Central

Walkosz, B.J.; Buller, D.B.; Andersen, P.A.; Scott, M.D.; Liu, X.; Cutter, G.R.; Dignan, M.B.

2015-01-01

Unprotected and excessive exposure to ultraviolet radiation is the primary risk factor for skin cancer. Promoting sun safety practices to children and adolescents who recreate outdoors has the potential to reduce skin cancer occurrence later in life. Go Sun Smart (GSS), a sun safety program for employees and guests of ski areas was distributed to determine if an enhanced disseminations strategy was more effective than a basic dissemination strategy at reaching parents at ski and snowboard schools. On-site observations of GSS use and surveys of 909 parents/caregivers with children enrolled in ski and snowboard schools were conducted and analyzed using techniques for clustered designs. No differences were identified by dissemination strategy. Greater implementation of GSS was associated with greater parental recall of materials but not greater sun protection practices. Greater recall of messages, regardless of level of implementation, resulted in greater sun protection practices for children. GSS effectiveness trial’s favorable findings may have been successfully translated to ski and snowboard school across the North American ski industry. Ski areas that used more of the program materials appeared to reach parents with sun safety advice and thus convinced them to take more precautions for their children. Sun safety need not be at odds with children’s outdoor recreation activities. PMID:25761916

Impact assessment of proposed ski areas: A GIS approach integrating biological, physical and landscape indicators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geneletti, Davide

Ski centres are characterized by significant environmental impacts that occur during both the construction and the operation phase. In Trentino, a well-known ski destination located in northern Italy, new ski areas were identified by planning tools without conducting a formal assessment of their effects on the environment. This paper presents a study to assess and compare the impacts of the proposed ski areas within two valleys strongly linked to winter tourism: the Fiemme and Fassa Valleys. The method is based on the computation of spatial indicators using a Geographical Information System (GIS) to predict and quantify critical impacts, such asmore » ecosystem loss and fragmentation, soil erosion, geomorphologic hazards, interference with flora and fauna, and visibility. Subsequently, multicriteria analysis was applied to generate composite indices, and to rank ski areas according to their overall suitability. Finally, sensitivity analyses allowed to test the stability of the results. The study concluded that two of the proposed ski areas are located in highly unsuitable environment, and the relevant plan provisions should be revised.« less

A simulation of cross-country skiing on varying terrain by using a mathematical power balance model

PubMed Central

Moxnes, John F; Sandbakk, Øyvind; Hausken, Kjell

2013-01-01

The current study simulated cross-country skiing on varying terrain by using a power balance model. By applying the hypothetical inductive deductive method, we compared the simulated position along the track with actual skiing on snow, and calculated the theoretical effect of friction and air drag on skiing performance. As input values in the model, air drag and friction were estimated from the literature, whereas the model included relationships between heart rate, metabolic rate, and work rate based on the treadmill roller-ski testing of an elite cross-country skier. We verified this procedure by testing four models of metabolic rate against experimental data on the treadmill. The experimental data corresponded well with the simulations, with the best fit when work rate was increased on uphill and decreased on downhill terrain. The simulations predicted that skiing time increases by 3%–4% when either friction or air drag increases by 10%. In conclusion, the power balance model was found to be a useful tool for predicting how various factors influence racing performance in cross-country skiing. PMID:24379718

A simulation of cross-country skiing on varying terrain by using a mathematical power balance model.

PubMed

Moxnes, John F; Sandbakk, Oyvind; Hausken, Kjell

2013-01-01

The current study simulated cross-country skiing on varying terrain by using a power balance model. By applying the hypothetical inductive deductive method, we compared the simulated position along the track with actual skiing on snow, and calculated the theoretical effect of friction and air drag on skiing performance. As input values in the model, air drag and friction were estimated from the literature, whereas the model included relationships between heart rate, metabolic rate, and work rate based on the treadmill roller-ski testing of an elite cross-country skier. We verified this procedure by testing four models of metabolic rate against experimental data on the treadmill. The experimental data corresponded well with the simulations, with the best fit when work rate was increased on uphill and decreased on downhill terrain. The simulations predicted that skiing time increases by 3%-4% when either friction or air drag increases by 10%. In conclusion, the power balance model was found to be a useful tool for predicting how various factors influence racing performance in cross-country skiing.

Sustainability of the Dissemination of an Occupational Sun Protection Program in a Randomized Trial

PubMed Central

Buller, David B.; Walkosz, Barbara J.; Andersen, Peter A.; Scott, Michael D.; Dignan, Mark B.; Cutter, Gary R.; Zhang, Xiao; Kane, Ilima L.

2012-01-01

The sustainability of an occupational sun safety program, Go Sun Smart (GSS), was explored in a randomized trial, testing dissemination strategies at 68 U.S. and Canadian ski areas in 2004-2007. All ski areas received GSS from the National Ski Areas Association through a Basic Dissemination Strategy (BDS) using conference presentations and free materials. Half of the ski areas were randomly assigned to a theory-based Enhanced Dissemination Strategy (EDS) with personal contact supporting GSS use. Use of GSS was assessed at immediate and long-term follow-up posttests by on-site observation. Use of GSS declined from the immediate (M=5.72) to the long-term follow-up (M=6.24), F[1,62]=6.95, p=.01, but EDS ski areas (M=6.53) continued to use GSS more than BDS ski areas (M=4.49), F(1,62)=5.75, p=0.02, regardless of observation, F(1,60)=0.05, p=.83. Despite declines over time, a group of ski areas had sustained high program use and active dissemination methods had sustained positive effects on GSS implementation. PMID:22102323

Effects of seasonal vitamin D deficiency and respiratory acidosis on bone metabolism markers in submarine crewmembers during prolonged patrols.

PubMed

Holy, Xavier; Collombet, Jean-Marc; Labarthe, Frédéric; Granger-Veyron, Nicolas; Bégot, Laurent

2012-02-01

The aim of the study was to determine the seasonal influence of vitamin D status on bone metabolism in French submariners over a 2-mo patrol. Blood samples were collected as follows: prepatrol and patrol days 20, 41, and 58 on crewmembers from both a winter (WP; n = 20) and a summer patrol (SP; n = 20), respectively. Vitamin D status was evaluated for WP and SP. Moreover, extended parameters for acid-base balance (Pco(2), pH, and bicarbonate), bone metabolism (bone alkaline phosphatase and COOH-terminal telopeptide of type I collagen), and mineral homeostasis (parathyroid hormone, ionized calcium and phosphorus) were scrutinized. As expected, SP vitamin D status was higher than WP vitamin D status, regardless of the considered experimental time. A mild chronic respiratory acidosis (CRA) was identified in both SP and WP submariners, up to patrol day 41. Such an occurrence paired up with an altered bone remodeling coupling (decreased bone alkaline phosphatase-to-COOH-terminal telopeptide of type I collagen ratio). At the end of the patrol (day 58), a partial compensation of CRA episode, combined with a recovered normal bone remodeling coupling, was observed in SP, not, however, in WP submariners. The mild CRA episode displayed over the initial 41-day submersion period was mainly induced by a hypercapnia resulting from the submarine-enriched CO(2) level. The correlated impaired bone remodeling may imply a physiological attempt to compensate this acidosis via bone buffering. On patrol day 58, the discrepancy observed in terms of CRA compensation between SP and WP may result from the seasonal influence on vitamin D status.

Securing the Borders: Creation of the Border Patrol Auxiliary

DTIC Science & Technology

2007-05-05

auxiliary members will be the elite members of the BPA who will attend training at the Border Patrol Academy to gain the knowledge and skills required to...recruits and greatly reducing start-up costs for the Border Patrol. It would appeal directly to ideal candidates for the elite tier-two service: new...program, which is a small, elite , and highly selective service. Tier-two members will have to be recruited from specific target populations. Based on the

Geosynchronous Patrol Orbit for Space Situational Awareness

NASA Astrophysics Data System (ADS)

Thompson, B.; Kelecy, T.; Kubancik, T.; Flora, T.; Chylla, M.; Rose, D.

Applying eccentricity to a geosynchronous orbit produces both longitudinal and radial motion when viewed in Earth-fixed coordinates. An interesting family of orbits emerges, useful for “neighborhood patrol” space situational awareness and other missions. The basic result is a periodic (daily), quasielliptical, closed path around a fixed region of the geosynchronous (geo) orbit belt, keeping a sensor spacecraft in relatively close vicinity to designated geo objects. The motion is similar, in some regards, to the relative motion that may be encountered during spacecraft proximity operations, but on a much larger scale. The patrol orbit does not occupy a fixed slot in the geo belt, and the east-west motion can be combined with north-south motion caused by orbital inclination, leading to even greater versatility. Some practical uses of the geo patrol orbit include space surveillance (including catalog maintenance), and general space situational awareness. The patrol orbit offers improved, diverse observation geometry for angles-only sensors, resulting in faster, more accurate orbit determination compared to simple inclined geo orbits. In this paper, we analyze the requirements for putting a spacecraft in a patrol orbit, the unique station keeping requirements to compensate for perturbations, repositioning the patrol orbit to a different location along the geo belt, maneuvering into, around, and out of the volume for proximity operations with objects within the volume, and safe end-of-life disposal requirements.

Medical Care Before and During the Winter Paralympic Games in Turin 2006, Vancouver 2010 and Sochi 2014

PubMed Central

Gawroński, Wojciech; Sobiecka, Joanna

2015-01-01

Medical care in disabled sports is crucial both as prophylaxis and as ongoing medical intervention. The aim of this paper was to present changes in the quality of medical care over the consecutive Paralympic Games (PG). The study encompassed 31 paralympians: Turin (11), Vancouver (12), and Sochi (8) competing in cross-country skiing, alpine skiing, biathlon and snowboarding. The first, questionnaire-based, part of the study was conducted in Poland before the PG. The athletes assessed the quality of care provided by physicians, physiologists, dieticians, and physiotherapists, as well as their cooperation with the massage therapist and the psychologist. The other part of the study concerned the athletes’ health before leaving for the PG, as well as their diseases and injuries during the PG. The quality of medical care was poor before the 2006 PG, but satisfactory before the subsequent PG. Only few athletes made use of psychological support, assessing it as poor before the 2006 PG and satisfactory before the 2010 and 2014 PG. The athletes’ health condition was good during all PG. The health status of cross-country skiers was confirmed by a medical fitness certificate before all PG, while that of alpine skiers only before the 2014 PG. There were no serious diseases; training injuries precluded two athletes from participation. The quality of medical care before the PG was poor, however, became satisfactory during the actual PG. The resulting ad hoc pattern deviates from the accepted standards in medical care in disabled sports. PMID:26834868

Ski Boots

NASA Technical Reports Server (NTRS)

1995-01-01

In cooperation with Raichle Molitor USA Inc. and the international Raichle organization, Comfort Products developed the Raichle Flexon concept in ski boots. The Flexon concept is an adaptation of the accordion-like corrugations of extravehicular space suit joints, which allows ski boots to flex without significant distortion. The design provides immediate transmission of power and therefore precision skiing. Comfort Products also applied heating element circuitry from Apollo astronaut's clothing to foot-warming devices in their boots in the 1970s.

Risk factors for the severity of injury incurred in crashes involving on-duty police cars.

PubMed

Chu, Hsing-Chung

2016-07-03

This article explores the risk factors associated with police cars on routine patrol and/or on an emergency run and their effects on the severity of injuries in crashes. The binary probit model is used to examine the effects of important factors on the risk of injuries sustained in crashes involving on-duty police cars. Several factors significantly increase the probability of crashes that cause severe injuries. Among those causes are police officers who drive at excessive speeds, traffic violations during emergency responses or pursuits, and driving during the evening (6 to 12 p.m.) or in rainy weather. Findings also indicate some potential issues associated with an increase in the probability of crashes that cause injuries. Younger police drivers were found to be more likely to be involved in crashes causing injuries than middle-aged drivers were. Distracted driving by on-duty police officers as well as civilian drivers who did not pull over to let a police car pass in emergency situations also caused serious crashes. Police cars are exempted from certain traffic laws under emergency circumstances. However, to reduce the probability of being involved in a crash resulting in severe injuries, officers are still obligated to drive safely and follow safety procedures when responding to emergencies or pursuing a car. Enhancement of training techniques for emergency situations or driving in pursuit of an offender and following the safety procedures are essential for safety in driving during an emergency run by police.

Wetlands and ski resorts in the French Alps: main issues and innovative ideas for the preservation of wetlands in ski areas

NASA Astrophysics Data System (ADS)

Gaucherand, S.; Evette, A.; François, H.; Paccard, P.; Perretier, C.; Wlerick, L.

2009-04-01

This presentation is a synthesis of a symposium held last October in Cemagref, Grenoble with contributions from scientists as well as lift operators, NGO's, and administrations. In the context of global change, ski resorts must rethink their development models. The diversification of the touristic offer is encouraged and the specificity of the mountain territory is at the heart of a sustainable development. In this context, the preservation of interesting and fragile habitats such as wetlands is topical. Wetlands have many recognized functions: flooding reduction, water remediation, fertilization, biodiversity conservation… In mountain areas, wetlands are small and scattered. They are of special interest in particular for their role in biodiversity conservation and for their cultural and recreational benefits. However, in ski areas, wetlands can interact with the ski activity. Indeed, wetlands can speed up snow melting in spring and they often occupy ledges, which are strategic positions for the establishment of ski resort's facilities. The development of ski resorts can lead to the destruction or the deterioration of wetlands because of hydrologic interferences, fill in, pollution, etc. However, a few judicious steps can be taken to reduce or suppress these negative effects. In the Alps, geographical and administrative tools have been developed to help the decisions of ski-resort's administrators. Meetings between lift-operators, administrators of protected areas scientists and NGO's have also proved efficient when done at an early stage of a project, as shown by the example of the ski-resort "Les Saisies".

The effects of poling on physiological, kinematic and kinetic responses in roller ski skating.

PubMed

Grasaas, Erik; Hegge, Ann Magdalen; Ettema, Gertjan; Sandbakk, Øyvind

2014-09-01

We investigated the effects of poling on physiological, kinematic and kinetic responses in the G4 skating technique where the poling movement is synchronized with the leg push-off on one side (strong side) followed by a forward arm swing during the leg push-off on the other side (weak side). G4 skating with (G4-P) and without (G4-NP) poling was compared in 17 elite male cross-country skiers during 4-min submaximal tests on a 2% inclined roller ski treadmill at 10, 15 and 20 km h(-1). G4-P demonstrated less ventilatory stress and higher gross efficiency compared to G4-NP at all velocities, and the blood lactate concentration was lower at the high velocity (all P < 0.05). Furthermore, longer cycle lengths and lower cycle rates were found with G4-P at all velocities, with correspondingly lower peak ski forces, increased ski velocities and less angling and edging of the skis (all P < 0.05). The peak ski forces on the strong side were lower than on the weak side with G4-P at all velocities (all P < 0.05), but no differences between the sides were found with G4-NP. The reduced physiological cost, higher gross efficiency and longer cycle lengths together with the lower ski forces at a given work rate with G4-P demonstrate the effectiveness of poling in the G4 skating technique. Thus, poling provides possibilities to increase total propulsion, to reduce ski forces and to enhance skiing efficiency.

How Do World-Class Nordic Combined Athletes Differ From Specialized Cross-Country Skiers and Ski Jumpers in Sport-Specific Capacity and Training Characteristics?

PubMed

Sandbakk, Øyvind; Rasdal, Vegard; Bråten, Steinar; Moen, Frode; Ettema, Gertjan

2016-10-01

To compare sport-specific laboratory capacities and the annual training of world-class Nordic combined (NC) athletes with specialized ski jumpers (SJ) and cross-country (XC) skiers. Five world-class athletes from each sports discipline were compared. Ski jump imitations were performed on a 3-dimensional force plate in NC athletes and SJ, whereas XC skiing characteristics were obtained from submaximal and maximal roller ski skating on a treadmill in NC athletes and XC skiers. In addition, anthropometrics and annual training characteristics were determined. NC athletes demonstrated 9% higher body mass and showed 17% lower vertical speed in the ski jump imitation than SJ (all P < .05). NC athletes had 12% lower body mass and showed 10% lower peak treadmill speed and 12% lower body-mass-normalized peak oxygen uptake than XC skiers (all P < .05). NC athletes performed half the number of ski-jumping-specific sessions and outdoor ski jumps compared with SJ. NC athletes performed 31% less endurance training, mainly caused by lower amounts of low- and moderate-intensity training in the classical technique, whereas high-intensity strength and speed training and endurance training in the skating technique did not differ substantially from XC skiers. To simultaneously optimize endurance, explosive, and technical capacities in 2 different disciplines, world-class NC athletes train approximately two-thirds of the XC skier's endurance training volume and perform one-half of the ski-jump-specific training compared with SJ. Still, the various laboratory capacities differed only 10-17% compared with SJ and XC skiers.

Risk of Severe Knee and Hip Osteoarthritis in Relation to Level of Physical Exercise: A Prospective Cohort Study of Long-Distance Skiers in Sweden

PubMed Central

Michaëlsson, Karl; Byberg, Liisa; Ahlbom, Anders; Melhus, Håkan; Farahmand, Bahman Y.

2011-01-01

Background To complete long-distance ski races, regular physical exercise is required. This includes not only cross-country skiing but also endurance exercise during the snow-free seasons. The aim of this study was to determine whether the level of physical exercise is associated with future risk of severe osteoarthritis independent of previous diseases and injuries. Methodology/Principal Findings We used a cohort that consisted of 48 574 men and 5 409 women who participated in the 90 km ski race Vasaloppet at least once between 1989 and 1998. Number of performed races and finishing time were used as estimates of exercise level. By matching to the National Patient Register we identified participants with severe osteoarthritis, defined as arthroplasty of knee or hip due to osteoarthritis. With an average follow-up of 10 years, we identified 528 men and 42 women with incident osteoarthritis. The crude rate was 1.1/1000 person-years for men and 0.8/1000 person-years for women. Compared with racing once, participation in ≥5 races was associated with a 70% higher rate of osteoarthritis (multivariable-adjusted hazard ratio (HR) 1.72, 95% confidence interval (CI) 1.33 to 2.22). The association was dose-dependent with an adjusted HR of 1.09, 95% CI 1.05 to 1.13 for each completed race. A faster finishing time, in comparison with a slow finishing time, was also associated with an increased rate (adjusted HR 1.51, 95% CI 1.14 to 2.01). Contrasting those with 5 or more ski races and a fast finish time to those who only participated once with a slow finish time, the adjusted HR of osteoarthritis was 2.73, 95% CI 1.78 to 4.18. Conclusions/Significance Participants with multiple and fast races have an increased risk of subsequent arthroplasty of knee and hip due to osteoarthritis, suggesting that intensive exercise may increase the risk. PMID:21479136

Coast Guard Acquisitions: Enhanced Oversight of Testing Could Benefit National Security Cutter Program and Future DHS Acquisitions

DTIC Science & Technology

2016-02-03

Response Cutter program and plans for its upcoming Offshore Patrol Cutter program, that the Coast Guard has matured its acquisition process. The process to...Cutter and Offshore Patrol Cutter programs. GAO reviewed these two programs in June 2014 (GAO-14-450) and April 2015 (GAO- 15-171SP) and also...Government Accountability Office areas of competition and the schedule for initial testing. Furthermore, as the $12 billion Offshore Patrol Cutter program

U. S. Naval Forces, Vietnam Monthly Historical Supplement for June 1967

DTIC Science & Technology

1967-09-17

Sat Special Zone River Patrol Group ..••««•.«.. e 3 Delta River Patrol Group ...o.....«•...« 6 GAME WARDM Units 0 .... . 12 GAME WARDEN...at certain Operation GAME WARDEN and Ojreratxcn MARKET TIME support bas5So The work performed by the Seabees was part of th« continuing "Level of...operational availability of MARKET TIME and GAME WARDEN patrol boats continued to be generally excellent 5, ranging from 80 percent for WPBs and PCFs

Development and validation of a new method for the registration of overuse injuries in sports injury epidemiology: the Oslo Sports Trauma Research Centre (OSTRC) overuse injury questionnaire.

PubMed

Clarsen, Benjamin; Myklebust, Grethe; Bahr, Roald

2013-05-01

Current methods for injury registration in sports injury epidemiology studies may substantially underestimate the true burden of overuse injuries due to a reliance on time-loss injury definitions. To develop and validate a new method for the registration of overuse injuries in sports. A new method, including a new overuse injury questionnaire, was developed and validated in a 13-week prospective study of injuries among 313 athletes from five different sports, cross-country skiing, floorball, handball, road cycling and volleyball. All athletes completed a questionnaire by email each week to register problems in the knee, lower back and shoulder. Standard injury registration methods were also used to record all time-loss injuries that occurred during the study period. The new method recorded 419 overuse problems in the knee, lower back and shoulder during the 3-month-study period. Of these, 142 were classified as substantial overuse problems, defined as those leading to moderate or severe reductions in sports performance or participation, or time loss. Each week, an average of 39% of athletes reported having overuse problems and 13% reported having substantial problems. In contrast, standard methods of injury registration registered only 40 overuse injuries located in the same anatomical areas, the majority of which were of minimal or mild severity. Standard injury surveillance methods only capture a small percentage of the overuse problems affecting the athletes, largely because few problems led to time loss from training or competition. The new method captured a more complete and nuanced picture of the burden of overuse injuries in this cohort.

The influence of increased distal loading on metabolic cost, efficiency, and kinematics of roller ski skating.

PubMed

Bolger, Conor M; Bessone, Veronica; Federolf, Peter; Ettema, Gertjan; Sandbakk, Øyvind

2018-01-01

The purpose of the present study was to examine the influence of increased loading of the roller ski on metabolic cost, gross efficiency, and kinematics of roller ski skating in steep and moderate terrain, while employing two incline-specific techniques. Ten nationally ranked male cross-country skiers were subjected to four 7-minute submaximal intervals, with 0, 0.5, 1.0, and 1.5 kg added beneath the roller-ski in a randomized order. This was done on two separate days, with the G2 skating at 12% incline and 7 km/h speed and G3 skating at 5% incline and 14 km/h speed, respectively. At 12% incline, there was a significant increase in metabolic rate and a decrease in gross efficiency with added weight (P<0.001 and P = 0.002). At 5% incline, no change in metabolic rate or gross efficiency was found (P = 0.89 and P = 0.11). Rating of perceived exertion (RPE) increased gradually with added weight at both inclines (P>0.05). No changes in cycle characteristics were observed between the different ski loadings at either incline, although the lateral and vertical displacements of the foot/skis were slightly altered at 12% incline with added weight. In conclusion, the present study demonstrates that increased loading of the ski increases the metabolic cost and reduces gross efficiency during steep uphill roller skiing in G2 skating, whereas no significant effect was revealed when skating on relatively flat terrain in G3. Cycle characteristics remained unchanged across conditions at both inclines, whereas small adjustments in the displacement of the foot coincided with the efficiency changes in uphill terrain. The increased RPE values with added ski-weight at both inclines indicates that other factors than those measured here could have influenced effort and/or fatigue when lifting a heavier ski.

Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma.

PubMed

Fukuchi, Minoru; Nakajima, Masanobu; Fukai, Yasuyuki; Miyazaki, Tatsuya; Masuda, Norihiro; Sohda, Makoto; Manda, Ryokuhei; Tsukada, Katsuhiko; Kato, Hiroyuki; Kuwano, Hiroyuki

2004-03-01

Transforming growth factor-beta (TGF-beta) regulates cell growth inhibition, and inactivation of the TGF-beta signaling pathway contributes to tumor development. In our previous study, altered expression of TGF-beta, TGF-beta-specific receptors and Smad4 was shown to correlate with tumor progression in esophageal squamous cell carcinoma (SCC). These components, however, were maintained normally in some patients with esophageal SCC. In our study, the mechanism by which aggressive esophageal SCC maintains these components was investigated, with particular emphasis on the participation of c-Ski and SnoN as transcriptional co-repressors in TGF-beta signaling. Immunohistochemistry for c-Ski and SnoN was carried out on surgical specimens obtained from 80 patients with esophageal SCC. The expression of c-Ski and SnoN was also studied in 6 established cell lines derived from esophageal SCC and compared to an immortalized human esophageal cell line by Western blotting. High levels of expression of c-Ski, detected immunohistologically, were found to correlate with depth of invasion (p = 0.0080) and pathologic stage (p = 0.0447). There was, however, no significant correlation between expression of SnoN and clinicopathologic characteristics. A significant correlation between c-Ski and TGF-beta expression was observed. Moreover, in patients with TGF-beta negative expression, the survival rates of patients with c-Ski positive expression were significantly lower than those of patients with c-Ski negative expression (p = 0.0486). c-Ski was expressed at a high level in 5 of 6 cell lines derived from esophageal SCC compared to immortalized esophageal keratinocytes. Furthermore, the cyclin-dependent kinase (CDK) inhibitor, p21 that was up-regulated by TGF-beta signaling was expressed at a low level in the 5 cell lines. The expression of c-Ski protein as a transcriptional co-repressor in TGF-beta signaling seems to be correlated with tumor progression of esophageal SCC. Copyright 2003 Wiley-Liss, Inc.

"no snow - no skiing excursion - consequences of climatic change?"

NASA Astrophysics Data System (ADS)

Neunzig, Thilo

2014-05-01

Climatology and climate change have become central topics in Geography at our school. Because of that we set up a climatological station at our school. The data are an important basis to observe sudden changes in the weather. The present winter (2013/2014) shows the importance of climate change in Alzey / Germany. In winter many students think of the yearly skiing trip to Schwaz / Austria which is part of our school programme. Due to that the following questions arise: Will skiing still be possible if climate change accelerates? How are the skiing regions in the Alpes going to change? What will happen in about 20 years? How does artificial snow change the landscape and the skiing sport? Students have to be aware of the ecological damage of skiing trips. Each class has to come up with a concept how these trips can be as environmentally friendly as possible. - the trip is for a restricted number of students only (year 8 only) - a small skiing region is chosen which is not overcrowded - snow has to be guaranteed in the ski area to avoid the production of artificial snow (avoidance of high water consumption) - the bus arrives with a class and returns with the one that had been there before These are but a few ideas of students in order to make their trip as environmentally friendly as possible. What is missing is only what is going to happen in the future. What will be the effect of climate change for skiing regions in the secondary mountains? How is the average temperature for winter going to develop? Are there possibilities for summer tourism (e.g. hiking) instead of skiing in winter? The students are going to try to find answers to these questions which are going to be presented on a poster on the GIFT-Workshop in Vienna.

32 CFR 700.922 - Shore patrol.

Code of Federal Regulations, 2010 CFR

2010-07-01

... on the part of any person on liberty. The senior patrol officer shall communicate with the chief of... the parent command, and providing other services that favorably influence discipline and morale. (b) A...

Service patrol handbook.

DOT National Transportation Integrated Search

2008-11-01

This Handbook provides an overview of the Full-Function Service Patrol (FFSP) and describes desired program characteristics from the viewpoint of an agency that is responsible for funding, managing, and operating the services. Presented guidelines an...

Dissemination of go sun smart in outdoor recreation: effect of program exposure on sun protection of guests at high-altitude ski areas.

PubMed

Walkosz, Barbara J; Buller, David B; Andersen, Peter A; Scott, Michael D; Dignan, Mark B; Cutter, Gary R; Liu, Xia; Maloy, Julie A

2014-09-01

Go Sun Smart is a theory-based health communication program designed to influence sun-protection behaviors of employees and guests at high-altitude ski areas to reduce skin cancer risk. The effects of Go Sun Smart, in a Phase IV dissemination randomized posttest-only trial, on sun-protection behaviors of ski area guests are reported. Program use was assessed by on-site observation and guest message exposure, and sun protection was measured in intercept surveys at ski areas. Dissemination strategy-enhanced versus basic-was not significantly related to sun safety practices. Additional analyses examined the relation between message exposure and guests' sun safety practices. Ski areas displaying at least 6 Go Sun Smart materials in guest-only areas and 9 Go Sun Smart materials throughout the area increased guests' message exposure. Higher message exposure within the high-use ski areas was associated with improved sun protection by guests but not within the low-use ski areas. The authors underscore the importance of program implementation and message exposure on the success of evidence-based health communication efforts applied industrywide.

Biomechanics research in ski jumping, 1991-2006.

PubMed

Schwameder, Hermann

2008-01-01

In this paper, I review biomechanics research in ski jumping with a specific focus on publications presented between 1991 and 2006 on performance enhancement, limiting factors of the take-off, specific training and conditioning, aerodynamics, and safety. The first section presents a brief description of ski jumping phases (in-run, take-off, early flight, stable flight, and landing) regarding the biomechanical and functional fundamentals. The most important and frequently used biomechanical methods in ski jumping (kinematics, ground reaction force analyses, muscle activation patterns, aerodynamics) are summarized in the second section. The third section focuses on ski jumping articles and research findings published after the establishment of the V-technique in 1991, as the introduction of this technique has had a major influence on performance enhancement, ski jumping regulations, and the construction of hill profiles. The final section proposes topics for future research in the biomechanics of ski jumping, including: take-off and early flight and the relative roles of vertical velocity and forward somersaulting angular momentum; optimal jumping patterns utilizing the capabilities of individual athletes; development of kinematic and kinetic feedback systems for hill jumps; comparisons of simulated and hill jumps; effect of equipment modifications on performance and safety enhancement.

The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor.

PubMed

Ferrand, Nathalie; Atfi, Azeddine; Prunier, Céline

2010-11-01

The oncoprotein c-Ski has been implicated in the negative regulation of transforming growth factor-β (TGF-β) signaling owing to its ability to repress Smad transcriptional activity via recruitment of a transcriptional corepressor complex containing histone deacetylases. However, c-Ski has also been shown to localize to the cytoplasm, raising the interesting possibility that it might disable TGF-β signaling through alternative mechanisms. Here, we provide evidence that c-Ski can restrict TGF-β signaling by interacting directly with the activated TGF-β type I receptor (TβRI). We explored the physiologic relevance of the c-Ski/TβRI interaction and found that it can culminate in a constitutive association of TβRI with a nonfunctional R-Smad/Smad4 complex. Based on these findings, we hypothesize that the interaction between c-Ski and TβRI might interfere with nuclear translocation of the R-Smad/Smad4 complex, thereby attenuating TGF-β signaling. Such a mechanism may play a crucial role in tumor progression, because many tumors that express high levels of c-Ski also display impaired nuclear accumulation of Smads. ©2010 AACR.

Musculoskeletal injury review in the U.S. space program.

PubMed

Jennings, R T; Bagian, J P

1996-08-01

Astronauts in NASA's space program are expected to remain fit to complete their on-orbit tasks and to function effectively in the event of contingency operations. Due to the generally self-directed exercise program and reliance on competitive sports and running for conditioning, plus limited emphasis on training techniques and rehabilitation, there have been a surprising number of orthopedic injuries and surgeries in this small adult population. This article examines the orthopedic injury history of U.S. astronauts during the period from 1987-95. The type of injury, activity involved, and subsequent surgical interventions are cataloged. There were a total of 26 fractures, 36 serious ligament, cartilage, or soft tissue injuries, and 28 orthopedic surgical procedures in this adult group with a mean astronaut corps size of only 94. Women accounted for 16% of the study population but accounted for only 1 of 28 surgical procedures. Knee injuries required surgical intervention 19 times. Running, skiing, and basketball were most frequently associated with injuries. The descriptive data regarding frequency of adverse events and activity associated with injuries is presented. These injury patterns are analyzed and suggestions made for future improvement, including decreased reliance on running and competitive athletics for conditioning, improved personal fitness training preflight, and coordinated rehabilitation postflight. Also recommended is the use of a lap pool for preflight total body fitness training, since swimming provides conditioning to those muscle groups used during spaceflight, and for variably weighted gravity rehabilitation postflight.

Appalachia's Winter Secret: Downhill on the Mountains.

ERIC Educational Resources Information Center

Johnson, Randy

1991-01-01

Describes ski-industry and winter-tourism growth in Appalachia. Sketches ski-resort developments in Maryland, Pennsylvania, North Carolina, and West Virginia. Describes economic threats to industry, its economic impact on Appalachian states and region, resorts' general qualities, and ski industry's promotional efforts. (TES)

14 CFR 27.505 - Ski landing conditions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Ski landing conditions. 27.505 Section 27.505 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Strength Requirements Ground Loads § 27.505 Ski landing...

14 CFR 29.505 - Ski landing conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Ski landing conditions. 29.505 Section 29.505 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Strength Requirements Ground Loads § 29.505 Ski landing...

14 CFR 27.505 - Ski landing conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Ski landing conditions. 27.505 Section 27.505 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Strength Requirements Ground Loads § 27.505 Ski landing...

14 CFR 29.505 - Ski landing conditions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Ski landing conditions. 29.505 Section 29.505 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Strength Requirements Ground Loads § 29.505 Ski landing...

Additional Smooth and Rough Water Trials of SKI-CAT.

DTIC Science & Technology

1981-08-01

REPORT & PERIOD COVERED ADDITIONAL SMOOTH AND ROUGH WATER TRIALS OF FINAL SKI- CAT S. PERFORMING ORO. REPORT NUMSER 7. AUTHOR() I. CONTRACT OR GRANT NUMUr...Identif by bloc membe) ’ " -Further tests of SKI- CAT were made in smooth and rough water. Smooth water results confirmed the performance results of...reductions in the accelerations and motions of SKI- CAT over against the head seasreut DD , +A ,3 1473 EDITION OF I NOVS IS OBSOLETE UNCIbSJFIED SIME 0102-014

Aligning policing and public health promotion: Insights from the world of foot patrol

PubMed Central

Wood, Jennifer D.; Taylor, Caitlin J.; Groff, Elizabeth R.; Ratcliffe, Jerry H.

2013-01-01

Foot patrol work is rarely described in relation to public health, even though police routinely encounter health risk behaviors and environments. Through a qualitative study of foot patrol policing in violent ‘hotspots’ of Philadelphia, we explore some prospects and challenges associated with bridging security and public health considerations in law enforcement. Noting existing efforts to help advance police officer knowledge of, and attitudes toward health vulnerabilities, we incorporate perspectives from environmental criminology to help advance this bridging agenda. Extending the notion of capable guardianship to understand foot patrol work, we suggest that the way forward for theory, policy and practice is not solely to rely on changing officer culture and behavior, but rather to advance a wider agenda for enhancing collective guardianship, and especially ‘place management’ for harm reduction in the city. PMID:26085825

Aligning policing and public health promotion: Insights from the world of foot patrol.

PubMed

Wood, Jennifer D; Taylor, Caitlin J; Groff, Elizabeth R; Ratcliffe, Jerry H

2015-05-01

Foot patrol work is rarely described in relation to public health, even though police routinely encounter health risk behaviors and environments. Through a qualitative study of foot patrol policing in violent 'hotspots' of Philadelphia, we explore some prospects and challenges associated with bridging security and public health considerations in law enforcement. Noting existing efforts to help advance police officer knowledge of, and attitudes toward health vulnerabilities, we incorporate perspectives from environmental criminology to help advance this bridging agenda. Extending the notion of capable guardianship to understand foot patrol work, we suggest that the way forward for theory, policy and practice is not solely to rely on changing officer culture and behavior, but rather to advance a wider agenda for enhancing collective guardianship, and especially 'place management' for harm reduction in the city.

Pregnancy outcomes after paternal radiofrequency field exposure aboard fast patrol boats.

PubMed

Baste, Valborg; Moen, Bente E; Oftedal, Gunnhild; Strand, Leif Age; Bjørge, Line; Mild, Kjell Hansson

2012-04-01

To investigate adverse reproductive outcomes among male employees in the Royal Norwegian Navy exposed to radiofrequency electromagnetic fields aboard fast patrol boats. Cohort study of Royal Norwegian Navy servicemen linked to the Medical Birth Registry of Norway, including singleton offspring born between 1967 and 2008 (n = 37,920). Exposure during the last 3 months before conception (acute) and exposure more than 3 months before conception (nonacute) were analyzed. Perinatal mortality and preeclampsia increased after service aboard fast patrol boats during an acute period and also after increased estimated radiofrequency exposure during an acute period, compared with service aboard other vessels. No associations were found between nonacute exposure and any of the reproductive outcomes. Paternal work aboard fast patrol boats during an acute period was associated with perinatal mortality and preeclampsia, but the cause is not clear.

Sex Differences in Balance Among Alpine Ski Racers: Cross-Sectional Age Comparisons.

PubMed

Raschner, Christian; Hildebrandt, Carolin; Mohr, Johanna; Müller, Lisa

2017-12-01

Although balance is a key ability in the strength demands of alpine ski racing, affecting both performance and injury prevention, few studies have examined balance or related sex differences among still-maturing athletes. In this 10-year study, we investigated cross-sectional balance performances at different age periods of a representative sample of over 500 11-18-year-old elite skiers of both genders. Participants performed balance tests using the MFT S3-Check. Left-right and forward-backward movements were used to calculate sensory and symmetry balance scores, which were both incorporated into a stability score. Mann-Whitney U tests assessed gender-specific differences by age-group with a significance level set at p < .05. Results showed gender differences only on forward-backward measurements for 14-16-year-olds, with females showing better stability and sensory (but not symmetry) scores than males. Thus, gender interacted with age and maturation to influence balance ability in these participants. Additionally, these rare 10-year data support coaches in their training and talent development of maturing athletes by providing important sport-, age-, and gender-specific normative comparison data for individual trainees.

Soil nitrogen dynamics in high-altitude ski runs during the winter season (Monterosaski - Vallée d

NASA Astrophysics Data System (ADS)

Freppaz, M.; Icardi, M.; Filippa, G.; Zanini, E.

2009-04-01

In many Alpine catchments, the development of winter tourism determined a widespread change in land use, shifting from forested and cultivated lands to ski slopes. The construction of a ski slope implies a strong impact on the landscape, with potential consequences on the soil quality. In most cases, the construction procedures include the total or partial removal of the soil body, the reallocation of the fine hearth fraction, the subsequent seeding of plants and the use of organic fertilizers. This work aims to evaluate soil physical and chemical properties and nitrogen (N) dynamics in anthropogenic soils from ski slopes of different age. Study sites were located in Champoluc (AO)- NW Italy between 2400 and 2700 m ASL. Topsoils (0-10 cm depth) were sampled in 4 ski slopes hydroseeded with commercial mixtures 4, 6, 10 and 12 years earlier, and in 4 control plots at the same exposure and altitude as the ski slopes. Soil samples were characterized, N dynamics in winter was evaluated with the buried bag technique and snowpack was analyzed for chemical and physical properties. Total nitrogen (TN) content in topsoil ranged 0.75-1.06 g kg-1 and was not correlated with the ski slope age. In all but one site, the TN content was significantly lower in the ski slope than in the control plot. A positive net ammonification and nitrification throughout the winter were found in all but one ski runs. These results suggest a high variability in the evolution degree of these anthropogenic soils. The net overwinter N mineralization that we report demonstrates that these soils are biologically active during the winter season. Such activity results in a pool of labile inorganic nitrogen potentially available for plant demand at the spring snowmelt.

Migration, Knowledge Transfer, and the Emergence of Australian Post-War Skiing: The Story of Charles William Anton

PubMed Central

Strobl, Philipp

2016-01-01

Abstract Skiing underwent substantial changes during the post-war years when the sport turned into a multi-billion dollar industry and a leisure activity for the masses. Despite its global nature and popularity, skiing in academic writing has not gained much recognition. This paper explores the role of knowledge transfer during the pioneering phase of post-war skiing in Australia. It describes the life of Charles William Anton, an Austrian refugee from the Anschluss who migrated to Sydney and subsequently became one of the founding fathers of Australian post-war skiing. The following pages show the multi-layered nature of skiing as a global sport by exemplifying how ideas spread from pre-war Europe to post-war Australia. The paper will also provide a case study about refugee knowledge transfer and the ‘productive process of absorption, adoption or rejection of knowledge’ that takes place once an idea has been introduced into a new environment. PMID:29170603

Migration, Knowledge Transfer, and the Emergence of Australian Post-War Skiing: The Story of Charles William Anton.

PubMed

Strobl, Philipp

2016-11-01

Skiing underwent substantial changes during the post-war years when the sport turned into a multi-billion dollar industry and a leisure activity for the masses. Despite its global nature and popularity, skiing in academic writing has not gained much recognition. This paper explores the role of knowledge transfer during the pioneering phase of post-war skiing in Australia. It describes the life of Charles William Anton, an Austrian refugee from the Anschluss who migrated to Sydney and subsequently became one of the founding fathers of Australian post-war skiing. The following pages show the multi-layered nature of skiing as a global sport by exemplifying how ideas spread from pre-war Europe to post-war Australia. The paper will also provide a case study about refugee knowledge transfer and the 'productive process of absorption, adoption or rejection of knowledge' that takes place once an idea has been introduced into a new environment.

In-Frame Mutations in Exon 1 of SKI Cause Dominant Shprintzen-Goldberg Syndrome

PubMed Central

Carmignac, Virginie; Thevenon, Julien; Adès, Lesley; Callewaert, Bert; Julia, Sophie; Thauvin-Robinet, Christel; Gueneau, Lucie; Courcet, Jean-Benoit; Lopez, Estelle; Holman, Katherine; Renard, Marjolijn; Plauchu, Henri; Plessis, Ghislaine; De Backer, Julie; Child, Anne; Arno, Gavin; Duplomb, Laurence; Callier, Patrick; Aral, Bernard; Vabres, Pierre; Gigot, Nadège; Arbustini, Eloisa; Grasso, Maurizia; Robinson, Peter N.; Goizet, Cyril; Baumann, Clarisse; Di Rocco, Maja; Sanchez Del Pozo, Jaime; Huet, Frédéric; Jondeau, Guillaume; Collod-Beroud, Gwenaëlle; Beroud, Christophe; Amiel, Jeanne; Cormier-Daire, Valérie; Rivière, Jean-Baptiste; Boileau, Catherine; De Paepe, Anne; Faivre, Laurence

2012-01-01

Shprintzen-Goldberg syndrome (SGS) is characterized by severe marfanoid habitus, intellectual disability, camptodactyly, typical facial dysmorphism, and craniosynostosis. Using family-based exome sequencing, we identified a dominantly inherited heterozygous in-frame deletion in exon 1 of SKI. Direct sequencing of SKI further identified one overlapping heterozygous in-frame deletion and ten heterozygous missense mutations affecting recurrent residues in 18 of the 19 individuals screened for SGS; these individuals included one family affected by somatic mosaicism. All mutations were located in a restricted area of exon 1, within the R-SMAD binding domain of SKI. No mutation was found in a cohort of 11 individuals with other marfanoid-craniosynostosis phenotypes. The interaction between SKI and Smad2/3 and Smad 4 regulates TGF-β signaling, and the pattern of anomalies in Ski-deficient mice corresponds to the clinical manifestations of SGS. These findings define SGS as a member of the family of diseases associated with the TGF-β-signaling pathway. PMID:23103230

SKIV2L Mutations Cause Syndromic Diarrhea, or Trichohepatoenteric Syndrome

PubMed Central

Fabre, Alexandre; Charroux, Bernard; Martinez-Vinson, Christine; Roquelaure, Bertrand; Odul, Egritas; Sayar, Ersin; Smith, Hilary; Colomb, Virginie; Andre, Nicolas; Hugot, Jean-Pierre; Goulet, Olivier; Lacoste, Caroline; Sarles, Jacques; Royet, Julien; Levy, Nicolas; Badens, Catherine

2012-01-01

Syndromic diarrhea (or trichohepatoenteric syndrome) is a rare congenital bowel disorder characterized by intractable diarrhea and woolly hair, and it has recently been associated with mutations in TTC37. Although databases report TTC37 as being the human ortholog of Ski3p, one of the yeast Ski-complex cofactors, this lead was not investigated in initial studies. The Ski complex is a multiprotein complex required for exosome-mediated RNA surveillance, including the regulation of normal mRNA and the decay of nonfunctional mRNA. Considering the fact that TTC37 is homologous to Ski3p, we explored a gene encoding another Ski-complex cofactor, SKIV2L, in six individuals presenting with typical syndromic diarrhea without variation in TTC37. We identified mutations in all six individuals. Our results show that mutations in genes encoding cofactors of the human Ski complex cause syndromic diarrhea, establishing a link between defects of the human exosome complex and a Mendelian disease. PMID:22444670

Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation

PubMed Central

Zhang, Song; Takaku, Motoki; Zou, Liyun; Gu, Ai-di; Chou, Wei-chun; Zhang, Ge; Wu, Bing; Kong, Qing; Thomas, Seddon Y.; Serody, Jonathan S.; Chen, Xian; Xu, Xiaojiang; Wade, Paul A.; Cook, Donald N.; Ting, Jenny P.; Wan, Yisong Y.

2017-01-01

Th17 cells are critically involved in host defense, inflammation, and autoimmunity1–5. TGF-β is instrumental in Th17 differentiation by cooperating with IL-66,7. Yet, the mechanism of how TGF-β enables Th17 differentiation remains elusive. Here we reveal that TGF-β licenses Th17 differentiation by releasing Ski-Smad4-complex suppressed RORγt expression. We found serendipitously that, unlike wild-type T cells, Smad4-deficient T cells differentiated into Th17 cells in the absence of TGF-β signaling in a RORγt-dependent manner. Ectopic Smad4 expression suppressed the RORγt expression and Th17 differentiation of Smad4-deficient T cells. Unexpectedly however, TGF-β neutralized Smad4 mediated suppression without affecting Smad4 binding to Rorc locus. Proteomic analysis revealed that Smad4 interacted with Ski, a transcriptional repressor degraded upon TGF-β stimulation. Ski controlled the histone acetylation/de-acetylation of Rorc locus and Th17 differentiation via Smad4 because ectopic Ski expression inhibited H3K9Ac of Rorc locus, Rorc expression and Th17 differentiation in a Smad4-dependent manner. Therefore, TGF-β-induced disruption of Ski releases Ski-Smad4 complex imposed suppression of RORγt to license Th17 differentiation. This study reveals a critical mechanism by which TGF-β controls Th17 differentiation and uncovers Ski-Smad4 axis as a potential therapeutic target for treating Th17 related diseases. PMID:29072299

Epidemiology of sports-related injuries in children and youth presenting to Canadian emergency departments from 2007-2010.

PubMed

Fridman, Liraz; Fraser-Thomas, Jessica L; McFaull, Steven R; Macpherson, Alison K

2013-12-23

Although injuries related to sports and recreation represent a significant burden to children and youth, few studies have examined the descriptive epidemiology of sports-related injury since 2005, and some sports such as ringette have not been evaluated to date. The primary purpose of this study was to provide the descriptive epidemiology of sports-related injuries treated in emergency departments for children and youth aged 5 - 19. A retrospective data analysis was performed using data from the Canadian Hospitals Injury Reporting and Prevention Program [CHIRPP] from fiscal years (April - March) 2007/08 to 2009/10. CHIRPP is a computerized information system designed by the Public Health Agency of Canada that collects information about injuries to people evaluated in emergency departments across 11 pediatric hospitals and 5 general hospitals in Canada. Thirteen sports or activities were analyzed (baseball, basketball, cycling, football, ice hockey, lacrosse, ringette, rugby, skiing, sledding, snowboarding, soccer, and volleyball). Descriptive statistics, including frequency by sport, age and sex, as well as the percent of concussions within each sport were calculated. Out of a total of 56, 691 reported sports and recreational injuries, soccer accounted for the largest proportion of injuries with 11,941 reported cases over the 3 year time period. Of these, approximately 30% were fractures. The 10 - 14 year age group reported the greatest proportion of injuries in 10 out of the 13 sports analyzed. In addition, males reported a greater number of overall injuries than females in 11 out of the 13 sports analyzed. The largest percentage of concussions was reported in ringette; these injuries accounted for 17.1% of overall injuries within this sport. Injury prevention programs in Canada should focus on improving evidence-based programs to reduce the burden of injuries in all sports.

Development of a safety service patrol uniform standard.

DOT National Transportation Integrated Search

1998-01-01

The Virginia Department of Transportation's (VDOT) Safety Service Patrollers (SSP) use different color uniforms depending on their geographic location. Red jumpsuits are used in the Northern Virginia District, orange jumpsuits are used in the Frederi...

Effects of an Alpine Ski Resort on Hydrology and Water Quality in the Northeastern U.S.: Preliminary Findings from a Field Study

NASA Astrophysics Data System (ADS)

Wemple, B.; Shanley, J.; Denner, J.

2002-12-01

High elevation, forested watersheds are particularly vulnerable to stresses from development. Steep slopes and thin soils rapidly transmit water, nutrients and sediment when disturbed by logging, road construction or other activities associated with development. The effects of forest harvesting practices on streamflow and water quality in high-elevation, forested watersheds have been well studied and provide relevant information about the susceptibility of these ecosystems to anthropogenic disturbance. Few studies have directly addressed the hydrologic or water quality effects of ski resort development on mountain streams, and these studies draw almost entirely from western U.S. examples. Ski resorts in the eastern U.S. face particular development pressures. Transient and unpredictable snow conditions generate extensive need for snowmaking. Competitive economic pressure has motivated plans for slope-side village development and summer recreation facilities at many eastern U.S. ski resorts. Here, we report preliminary findings of a recently initiated paired-watershed study to examine the effects of alpine ski area development on water quantity and quality. Our study area is located on the eastern slope of Mt. Mansfield, Vermont, and includes the basins of Ranch Brook (9.6 sq km) and West Branch (11.7 sq km). Ranch Brook is undeveloped, except for a network of cross-country ski trails and unsurfaced access roads, and serves as our control watershed. West Branch encompasses nearly an entire major ski resort, with an extensive network of alpine ski lifts and trails, day lodges, snowmaking facilities, and vacation homes. A major expansion of resort facilities and ski trails has recently received state approval. Our preliminary analysis indicates distinct differences in runoff and water quality between the two basins. Differences in basin hydrographs suggest that ski trails alter the timing and magnitude of runoff, particularly during spring snowmelt. Elevated concentrations of total suspended solids in West Branch streamwater suggest that exposed surfaces (trails, parking lots) may be important sources of sediment in the ski resort basin. Streamwater chemistry at West Branch also suggests contamination by deicing salts. Variability in summer low flows between the two basins indicates unexplained differences in precipitation capture or groundwater loss in the basins and must be resolved in future analysis. These findings provide important baseline information for ski area management in the eastern U.S., where field studies have been sparse. Our future plans include hydrologic modeling to assess the effects of current development and various future development scenarios on streamflow and water quality.

Application of ant colony algorithm in path planning of the data center room robot

NASA Astrophysics Data System (ADS)

Wang, Yong; Ma, Jianming; Wang, Ying

2017-05-01

According to the Internet Data Center (IDC) room patrol robot as the background, the robot in the search path of autonomous obstacle avoidance and path planning ability, worked out in advance of the robot room patrol mission. The simulation experimental results show that the improved ant colony algorithm for IDC room patrol robot obstacle avoidance planning, makes the robot along an optimal or suboptimal and safe obstacle avoidance path to reach the target point to complete the task. To prove the feasibility of the method.

Coast Guard: Strategies for Mitigating the Loss of Patrol Boats Are Achieving Results in the Near Term, but They Come at a Cost and Longer Term Sustainability Is Unknown

DTIC Science & Technology

2008-06-01

Committee on Commerce, Science, and Transportation, U.S. Senate The Coast Guard’s 110-foot patrol boats are used for a number of missions, such as...implemented a number of strategies. These mitigation strategies nclude: using the crews from the eight patrol boats removed from service to ugment...55 Page i GAO-08-660 Coast Guard Tables Table 1: Information on the Vessel Classes Used to Provide Operational Hours in

On the asteroid hazard

NASA Astrophysics Data System (ADS)

Eneev, T. M.; Akhmetshin, R. Z.; Efimov, G. B.

2012-04-01

The concept of "space patrol" is considered, aimed at discovering and cataloging the majority of celestial bodies that constitute a menace for the Earth [1, 2]. The scheme of "optical barrier" formed by telescopes of the space patrol is analyzed, requirements to the observation system are formulated, and some schemes of sighting the optical barrier region are suggested (for reliable detection of the celestial bodies approaching the Earth and for determination of their orbits). A comparison is made of capabilities of electro-jet engines and traditional chemical engines for arrangement of patrol spacecraft constellation in the Earth's orbit.

Study of ground handling characteristics of a maritime patrol airship

NASA Technical Reports Server (NTRS)

1981-01-01

Mooring concepts appropriate for maritime patrol airship (MPA) vehicles are investigated. The evolution of ground handling systems and procedures for all airship types is reviewed to ensure that appropriate consideration is given to past experiences. A tri-rotor maritime patrol airship is identified and described. Wind loads on a moored airship and the effects of these loads on vehicle design are analyzed. Several mooring concepts are assessed with respect to the airship design, wind loads, and mooring site considerations. Basing requirements and applicability of expeditionary mooring also are addressed.

GATEWAY Demonstrations: LED System Performance in a Trial Installation--Two Years Later, Yuma Border Patrol, Yuma, Arizona

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkerson, Andrea M.; Sullivan, Gregory P.; Davis, Robert G.

Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This report follows the GATEWAY Yuma Phase 1.1 Report and reflects LED system results documented two years after the demonstration began.

GATEWAY Demonstrations: LED System Performance in a Trial Installation--One Year Later, Yuma Border Patrol, Yuma, Arizona

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkerson, A. M.; Davis, R. G.

Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This report follows the GATEWAY Yuma Phase 1.0 Report and reflects LED system results documented one year after the demonstration began.

Notes on Antarctic Aviation

DTIC Science & Technology

1993-08-01

4 5. Curtiss-Wright T -32 biplane used by the second Byrd Antarctic Expedition...pack ice north of Mawson ............................................ 7 10. USN ski-wheel Douglas R4D-8 at McMurdo...McMurdo ................. 11 17. ANARE ski-wheel DHC-2 Beaver over Mawson ............................................ 12 18. USN ski-wheel DHC-3 Otter

Alpine Skiing in the Classroom

ERIC Educational Resources Information Center

Mendez-Gimenez, Antonio; Fernandez-Rio, Javier

2012-01-01

Many students settle indoors in the winter. However, this does not mean that winter should be a period of time with no physical activity. Several snow activities could be practiced during those months, such as ice-skating, ice-hockey, snowshoeing, cross-country skiing, alpine skiing, or snowboarding. In order to counteract the tendency for…

Projected climate change impacts on skiing and snowmobiling: A case study of the United States

EPA Science Inventory

A physically-based water and energy balance model is used to simulate natural snow accumulation at 247 winter recreation locations across the continental United States. We combine this model with projections of snowmaking conditions to determine downhill skiing, cross-country ski...

a Study on Mental Representations for Realistic Visualization the Particular Case of Ski Trail Mapping

NASA Astrophysics Data System (ADS)

Balzarini, R.; Dalmasso, A.; Murat, M.

2015-08-01

This article presents preliminary results from a research project in progress that brings together geographers, cognitive scientists, historians and computer scientists. The project investigates the evolution of a particular territorial model: ski trails maps. Ski resorts, tourist and sporting innovations for mountain economies since the 1930s, have needed cartographic representations corresponding to new practices of the space.Painter artists have been involved in producing ski maps with painting techniques and panoramic views, which are by far the most common type of map, because they allow the resorts to look impressive to potential visitors. These techniques have evolved throughout the mutations of the ski resorts. Paper ski maps no longer meet the needs of a large part of the customers; the question now arises of their adaptation to digital media. In a computerized process perspective, the early stage of the project aims to identify the artist-representations, based on conceptual and technical rules, which are handled by users-skiers to perform a task (location, wayfinding, decision-making) and can be transferred to a computer system. This article presents the experimental phase that analyzes artist and user mental representations that are at stake during the making and the reading of a paper ski map. It particularly focuses on how the invention of the artist influences map reading.

Targeting Sphingosine Kinase-1 To Inhibit Melanoma

PubMed Central

Madhunapantula, SubbaRao V.; Hengst, Jeremy; Gowda, Raghavendra; Fox, Todd E.; Yun, Jong K; Robertson, Gavin P.

2012-01-01

SUMMARY Resistance to therapies develops rapidly for melanoma leading to more aggressive disease. Therefore, agents are needed that specifically inhibit proteins or pathways controlling the development of this disease, which can be combined, dependent on genes deregulated in a particular patient’s tumors. This study shows that elevated sphingosine-1-phosphate (S-1-P) levels resulting from increased activity of sphingosine kinase-1 (SPHK1) occur in advanced melanomas. Targeting SPHK1 using siRNA decreased anchorage dependent and independent growth as well as sensitized melanoma cells to apoptosis inducing agents. Pharmacological SPHK1 inhibitors SKI-I but not SKI-II decreased S-1-P content, elevated ceramide levels, caused a G2-M block and induced apoptotic cell death in melanomas. Targeting SPHK1 using siRNA or the pharmacological agent called SKI-I, decreased the levels of pAKT. Furthermore, SKI-I inhibited the expression of CYCLIN D1 protein and increased the activity of caspase-3/7, which in turn led to the degradation of PARP. In animals, SKI-I but not SKI-II retarded melanoma growth by 25-40%. Thus, targeting SPHK1 using siRNAs or SKI-I has therapeutic potential for melanoma treatment either alone or in combination with other targeted agents. PMID:22236408

Translation of a Ski School Sun Safety Program to North American Ski and Snowboard Schools.

PubMed

Walkosz, Barbara J; Buller, David B; Andersen, Peter A; Scott, M D; Liu, X; Cutter, G R; Dignan, M B

2015-07-01

Health promotion programs that develop and implement strategies to promote sun safety practices to children have the potential to reduce skin cancer occurrence later in life. Go Sun Smart (GSS), a sun safety program for employees and guests of ski areas, was distributed to determine if an enhanced dissemination strategy was more effective than a basic dissemination strategy at reaching parents at ski and snowboard schools. On-site observations of GSS use and surveys of 909 parents/caregivers with children enrolled in ski and snowboard schools at 63 ski areas were conducted and analyzed using techniques for clustered designs. No differences were identified by dissemination strategy. Greater implementation of GSS (>5 messages posted) was associated with greater parental recall, 36.6% versus 16.7%, of materials, but not greater sun protection practices. Greater recall of messages, regardless of level of implementation, resulted in greater sun protection practices including applying sunscreen (p < .05), providing sunglasses and goggles (p < .01), and more use of all sun protection practices (p < .01). Ski areas with more program materials appeared to reach parents with sun safety advice and thus convinced them to take more precautions for their children. Sun safety need not be at odds with children's outdoor recreation activities. © 2015 Society for Public Health Education.

The importance of being light: aerodynamic forces and weight in ski jumping.

PubMed

Schmölzer, B; Müller, W

2002-08-01

Many contemporary world class ski jumpers are alarmingly underweight and several cases of anorexia nervosa have come to light. Athletes strive for low body weight because it gives them a major competitive advantage. In order to stop this hazardous development, changes to the regulations are being discussed, and the International Ski Federation and the International Olympic Committee wish to be proactive in safe guarding the interest of the athletes and their health. This study of ski jumping uses field studies conducted during World Cup competitions, large-scale wind tunnel measurements with 1:1 models of ski jumpers in current equipment and highly accurate computer simulations of the flight phase that include the effects due to the athlete's position changes. Particular attention has been directed to the design of a reference jump that mirrors current flight style and equipment regulations (2001), and to the investigation of effects associated with variation in body mass, air density, and wind gusts during the simulated flight. The detailed analysis of the physics of ski jumping described here can be used for the investigation of all initial value and parameter variations that determine the flight path of a ski jumper and will form a reliable basis for setting regulations that will make it less attractive or even disadvantageous for the athlete to be extremely light.

Soil properties in high-elevation ski slopes

NASA Astrophysics Data System (ADS)

Filippa, Gianluca; Freppaz, Michele; Letey, Stéphanie; Corti, Giuseppe; Cocco, Stefania; Zanini, Ermanno

2010-05-01

The development of winter sports determines an increasing impact on the high altitude ecosystems, as a consequence of increased participation and an increasing demand of high quality standards for skiable areas. The construction of a ski slope is associated with a certain impact on soil, which varies as a function of the degree of human-induced disturbance to the native substrata. In this work, we provide a description of the characteristics of alpine tundra ski-slope soils and their nutrient status, contrasted with undisturbed areas. The study site is located in the Monterosaski Resort, Aosta Valley, NW Italy (45°51' N; 7°48' E). We chose 5 sites along an altitudinal gradient between 2700 and 2200 m a.s.l.. Per each site, one plot was established on the ski slope, while a control plot was chosen under comparable topographic conditions a few meters apart. Soils were described and samples were collected and analysed for main chemical-physical properties. In addition an evaluation of N forms, organic matter fractionation and microbial biomass was carried out. Soil depth ranged between 10 to more than 70 cm, both on the ski slope and in the undisturbed areas. A true organo-mineral (A) horizon was firstly identified at 2500 m a.s.l., while a weathering horizon (Bw) was detected at 2400 m a.s.l.. However, a Bw horizon thick enough to be recognised as diagnostic for shifting soil classification order from Entisols to Inceptisols (USDA-Soil Taxonomy) was detected only below 2400 m a.s.l.. Lithic Cryorthents were predominant in the upper part of the sequence (above 2500 m a.s.l.), both in the ski slope and the undisturbed areas; Typic Cryorthents were identified between 2500 and 2400 m a.s.l., while Inceptisols were predominant between 2400 and 2200 m a.s.l.. Chemical-physical properties will be discussed focusing on the main differences between ski slope and undisturbed soils, as determined by the ski slope construction. Pedogenetic processes at high altitude are strongly limited by extreme climatic conditions, resulting in low resistance and resilience with respect to any human-induced changes; therefore, it is key to quantify the impact of ski slope construction and management on such fragile pedo-ecosystems. KEYWORDS: alpine tundra, pedogenesis, ski slope construction, ski slope management

33 CFR 5.48 - Auxiliary Patrol Boat ensign.

Code of Federal Regulations, 2014 CFR

2014-07-01

... this part. (b) The field of the Auxiliary Patrol Boat ensign is white. A medium blue (Coast Guard blue... hoist, by two narrow, parallel stripes, first a white stripe and then a medium blue (Coast Guard blue...

33 CFR 5.48 - Auxiliary Patrol Boat ensign.

Code of Federal Regulations, 2011 CFR

2011-07-01

... this part. (b) The field of the Auxiliary Patrol Boat ensign is white. A medium blue (Coast Guard blue... hoist, by two narrow, parallel stripes, first a white stripe and then a medium blue (Coast Guard blue...

33 CFR 5.48 - Auxiliary Patrol Boat ensign.

Code of Federal Regulations, 2012 CFR

2012-07-01

... this part. (b) The field of the Auxiliary Patrol Boat ensign is white. A medium blue (Coast Guard blue... hoist, by two narrow, parallel stripes, first a white stripe and then a medium blue (Coast Guard blue...

33 CFR 5.48 - Auxiliary Patrol Boat ensign.

Code of Federal Regulations, 2013 CFR

2013-07-01

... this part. (b) The field of the Auxiliary Patrol Boat ensign is white. A medium blue (Coast Guard blue... hoist, by two narrow, parallel stripes, first a white stripe and then a medium blue (Coast Guard blue...

33 CFR 5.48 - Auxiliary Patrol Boat ensign.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this part. (b) The field of the Auxiliary Patrol Boat ensign is white. A medium blue (Coast Guard blue... hoist, by two narrow, parallel stripes, first a white stripe and then a medium blue (Coast Guard blue...

Tone-activated, remote, alert communication system

NASA Technical Reports Server (NTRS)

Baker, C. D.; Couvillon, L. A.; Hubbard, W. P.; Kollar, F. J.; Postal, R. B.; Tegnelia, C. R.

1971-01-01

Pocket sized transmitter, frequency modulated by crystal derived tones, with integral loop antenna provides police with easy operating alert signal communicator which uses patrol car radio to relay signal. Communication channels are time shared by several patrol units.

Ten years of major equestrian injury: are we addressing functional outcomes?

PubMed Central

Ball, Jill E; Ball, Chad G; Mulloy, Robert H; Datta, Indraneel; Kirkpatrick, Andrew W

2009-01-01

Background Horseback riding is considered more dangerous than motorcycle riding, skiing, automobile racing, football and rugby. The integral role of rehabilitation therapy in the recovery of patients who have sustained a major horse-related injury is previously not described. The goals of this paper were to (1) define the incidence and pattern of severe equestrian trauma, (2) identify the current level of in-patient rehabilitation services, (3) describe functional outcomes for patients, and (4) discuss methods for increasing rehabilitation therapy in this unique population. Methods and results A retrospective review of the trauma registry at a level 1 center (1995–2005) was completed in conjunction with a patient survey outlining formal in-hospital therapy. Forty-nine percent of patients underwent in-patient rehabilitation therapy. Injuries predictive of receiving therapy included musculoskeletal and spinal cord trauma. Previous injury while horseback riding was predictive of not receiving therapy. The majority (55%) of respondents had chronic physical difficulties following their accident. Conclusion Rehabilitation therapy is significantly underutilized following severe equestrian trauma. Increased therapy services should target patients with brain, neck and skull injuries. Improvements in the initial provision, and follow-up of rehabilitation therapy could enhance functional outcomes in the treatment resistant Western equestrian population. PMID:19228424

SkiSim - A semi-distributed model to assess the impact of climate change on ski season length and snowmaking

NASA Astrophysics Data System (ADS)

Steiger, R.

2009-04-01

Winter tourism is highly sensitive to climate change. The altitudinally- dependent line of natural snow reliability (e.g. Abegg et al. 2007) is losing its relevance for skilift operators, as for example in Tyrol 70% of the ski slopes are already covered by technical snow production. Less snowfall at lower altitudes and rising temperatures increase the demand for technical snow. Simultaneously, periods cold enough for snowmaking will get shorter and less frequent. Studies incorporating snowmaking are still rare and there is need for an assessment of the suitability of snowmaking as a successful adaptation strategy. The aim of this study is to assess the development of ski season lengths and snowmaking requirements under different climate change scenarios for ski areas in North and South Tyrol. A semi-distributed ski season model "SkiSim" was developed based on the temperature-index snow model of Kleindienst (2000) and the ski season model of Scott et al. (2007). As input variables only daily minimum and maximum temperature and precipitation are needed. Additionally, measured snowfall and snow depth are used for the calibration of the snowfall temperature at each climate station. Further snow model parameters (e.g. degree-day factor, snow metamorphosis) were adopted from Kleindienst (2000) and tested at all stations. Snowmaking module parameters were derived from interviews with ski area managers based on the methodology of Scott et al. (2007). Daily data (1960-2100) of the high resolution climate model REMO (10x10km) was used to produce climate change scenarios for four time horizons (2020s, 2030s, 2050s, 2080s) under two emission scenarios (A1B and B1). The climate change signal for change in temperature, (in standard deviation of temperature, in precipitation and in dry and wet spells) was processed on climate station data by the LARS weather generator. In winter (DJF), the change signal for daily average temperature from the 2020s to 2080s compared to 1971-2000 is +1,4°C to +3,5°C in the B1 scenario, and from +1,2°C to 5,7°C in the A1B scenario. Precipitation change in the A1B scenario is between +5% and +10%, in B1 it is +5% to +20%. The synthetic daily data produced by LARS-WG is the input data for the ski season model. Temperature and precipitation are distributed for each 100m altitude band, ranging from the lowest to the highest point of the ski area. The ski season model produces results for the whole ski area and not just for one single point (e.g. the lowest point in a ski area). Thus it is possible to assess the impact of climate change on ski season length and snowmaking in much greater detail than in previous studies. Based on these results, the consequences for winter tourism destinations can be assessed. Following the methodology of Breiling et al. (1997, 2008), the contribution of winter tourism to the regional economy and the number employments in tourism serve as an indicator for the vulnerability of communities and regions to climate change. In total 120 ski areas in North and South Tyrol are investigated in the running project. Results of three ski areas, different in size and altitude, will be presented. Sources: Abegg, B., S. Agrawala, Crick, F., de Montfalcon, A. (2007): Climate change impacts and adaptation in winter tourism. In: S. Agrawala, Climate Change in the European Alps. Adapting Winter Tourism and Natural Hazards Management. Paris, OECD: 25-60. Breiling, M., Charamza, P., Skage, O. (1997): Klimasensibilität österreichischer Bezirke mit besonderer Berücksichtigung des Wintertourismus. Rapport 1,Department of Landscape Planning Alnarp, Swedish University of Agricultural Sciences. Breiling, M., Charamza, P.,Feilmayr, W. (2008): Klimasensibilität des Salzburger Wintertourismus nach Bezirken, TTL, TU Vienna. Kleindienst, H. (2000): Snow hydrological models as tools for snow cover assessment and water resources management, Bern. Phd. Scott, D., G. McBoyle, Minogue, A. (2007): Climate Change and Quebećs Ski Industry. In: Global Environmental Change 17, 181-190.

Group augmentation, collective action, and territorial boundary patrols by male chimpanzees

PubMed Central

Langergraber, Kevin E.; Watts, David P.; Mitani, John C.

2017-01-01

How can collective action evolve when individuals benefit from cooperation regardless of whether they pay its participation costs? According to one influential perspective, collective action problems are common, especially when groups are large, but may be solved when individuals who have more to gain from the collective good or can produce it at low costs provide it to others as a byproduct. Several results from a 20-y study of one of the most striking examples of collective action in nonhuman animals, territorial boundary patrolling by male chimpanzees, are consistent with these ideas. Individuals were more likely to patrol when (i) they had more to gain because they had many offspring in the group; (ii) they incurred relatively low costs because of their high dominance rank and superior physical condition; and (iii) the group size was relatively small. However, several other findings were better explained by group augmentation theory, which proposes that individuals should bear the short-term costs of collective action even when they have little to gain immediately if such action leads to increases in group size and long-term increases in reproductive success. In support of this theory, (i) individual patrolling effort was higher and less variable than participation in intergroup aggression in other primate species; (ii) males often patrolled when they had no offspring or maternal relatives in the group; and (iii) the aggregate patrolling effort of the group did not decrease with group size. We propose that group augmentation theory deserves more consideration in research on collective action. PMID:28630310

An overview of the "Positive Action for Today's Health" (PATH) trial for increasing walking in low income, ethnic minority communities.

PubMed

Wilson, Dawn K; Trumpeter, Nevelyn N; St George, Sara M; Coulon, Sandra M; Griffin, Sarah; Lee Van Horn, M; Lawman, Hannah G; Wandersman, Abe; Egan, Brent; Forthofer, Melinda; Goodlett, Benjamin D; Kitzman-Ulrich, Heather; Gadson, Barney

2010-11-01

Ethnic minorities and lower-income adults have among the highest rates of obesity and lowest levels of regular physical activity (PA). The Positive Action for Today's Health (PATH) trial compares three communities that are randomly assigned to different levels of an environmental intervention to improve safety and access for walking in low income communities. Three communities matched on census tract information (crime, PA, ethnic minorities, and income) were randomized to receive either: an intervention that combines a police-patrolled-walking program with social marketing strategies to promote PA, a police-patrolled-walking only intervention, or no-walking intervention (general health education only). Measures include PA (7-day accelerometer estimates), body composition, blood pressure, psychosocial measures, and perceptions of safety and access for PA at baseline, 6, 12, 18, and 24 months. The police-patrolled walking plus social marketing intervention targets increasing safety (training community leaders as walking captains, hiring off-duty police officers to patrol the walking trail, and containing stray dogs), increasing access for PA (marking a walking route), and utilizes a social marketing campaign that targets psychosocial and environmental mediators for increasing PA. MAIN HYPOTHESES/OUTCOMES: It is hypothesized that the police-patrolled walking plus social marketing intervention will result in greater increases in moderate-to-vigorous PA as compared to the police-patrolled-walking only or the general health intervention after 12 months and that this effect will be maintained at 18 and 24 months. Implications of this community-based trial are discussed. Copyright © 2010. Published by Elsevier Inc.

An overview of the “Positive Action for Today's Health” (PATH) trial for increasing walking in low income, ethnic minority communities

PubMed Central

Wilson, Dawn K.; Trumpeter, Nevelyn N.; St. George, Sara M.; Coulon, Sandra M.; Griffin, Sarah; Van Horn, M. Lee; Lawman, Hannah G.; Wandersman, Abe; Egan, Brent; Forthofer, Melinda; Goodlett, Benjamin D.; Kitzman-Ulrich, Heather; Gadson, Barney

2012-01-01

Background Ethnic minorities and lower-income adults have among the highest rates of obesity and lowest levels of regular physical activity (PA). The Positive Action for Today's Health (PATH) trial compares three communities that are randomly assigned to different levels of an environmental intervention to improve safety and access for walking in low income communities. Design and setting Three communities matched on census tract information (crime, PA, ethnic minorities, and income) were randomized to receive either: an intervention that combines a police-patrolled-walking program with social marketing strategies to promote PA, a police-patrolled-walking only intervention, or no-walking intervention (general health education only). Measures include PA (7-day accelerometer estimates), body composition, blood pressure, psychosocial measures, and perceptions of safety and access for PA at baseline, 6, 12, 18, and 24 months. Intervention The police-patrolled walking plus social marketing intervention targets increasing safety (training community leaders as walking captains, hiring off-duty police officers to patrol the walking trail, and containing stray dogs), increasing access for PA (marking a walking route), and utilizes a social marketing campaign that targets psychosocial and environmental mediators for increasing PA. Main hypotheses/outcomes It is hypothesized that the police-patrolled walking plus social marketing intervention will result in greater increases in moderate-to-vigorous PA as compared to the police-patrolled-walking only or the general health intervention after 12 months and that this effect will be maintained at 18 and 24 months. Conclusions Implications of this community-based trial are discussed. PMID:20801233

Incident management assistance patrols - assessment of benefits/costs, route selection, and prioritization : final report.

DOT National Transportation Integrated Search

2016-09-21

The North Carolina Department of Transportation's (NCDOTs) Incident Management Assistance Patrol (IMAP) program provides a critically important service to North Carolinas traveling public. The highly trained and well-equipped IMAP operators pro...

Repression of TGF-beta signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasis.

PubMed

Medrano, Estela E

2003-05-19

Transforming growth factor-beta (TGF-beta ) has dual and paradoxical functions as a tumor suppressor and promoter of tumor progression and metastasis. TGF-Ji-mediated growth inhibition is gradually lost during melanoma tumor progression, but there are no measurable defects at the receptor level. Furthermore, melanoma cells release high levels of TGF-beta to the microenvironment, which upon activation induces matrix deposition, angiogenesis, survival, and transition to more aggressive phenotypes. The SKI and SnoN protein family associate with and repress the activity of Smad2, Smad3, and Smad4, three members of the TGF-fl signaling pathway. SKI also facilitates cell-cycle progression by targeting the RB pathway by at least two ways: it directly associates with RB and represses its activity when expressed at high levels, and indirectly, it represses Smad-mediated induction of p21(Waf-1) This results in increased CDK2 activity, RB phosphorylation,and inactivation. Therefore, high levels of SKI result in lesions to the RB pathway in a manner similar to p16 (INK4a) loss. SKI mRNA and protein levels dramatically increase during human melanoma tumor progression. In addition,the SKI protein shifts from nuclear localization in intraepidermal melanoma cells to nuclear and cytoplasmic in invasive and metastatic melanomas. Here, I discuss the basis for repression of intracellular TGF-beta signaling by SKI, some additional activities of this protein, and propose that by disrupting multiple tumor suppressor pathways, SKI functions as a melanoma oncogene.

High Performance Skiing. How to Become a Better Alpine Skier.

ERIC Educational Resources Information Center

Yacenda, John

This book is intended for people who desire to improve their skiing by exploring high performance techniques leading to: (1) more consistent performance; (2) less fatigue and more endurance; (3) greater strength and flexibility; (4) greater versatility; (5) greater confidence in all skiing conditions; and (6) the knowledge to participate in…

78 FR 60816 - Proposed Directive for Additional Seasonal or Year-Round Recreation Activities at Ski Areas

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... Authorized Officers to ensure that ski area operations comply with Forest Service regulations and permit... significant modifications to topography to facilitate construction or operations. The Agency is also proposing... in the ski area's master development plan; (2) Not compromise snow sports operations or functions...

Go Sun Smart

ERIC Educational Resources Information Center

Scott, Michael D.; Buller, David B.; Walkosz, Barbara J.; Andersen, Peter A.; Cutter, Gary R.; Dignan, Mark B.

2008-01-01

This is the story of Go Sun Smart, a worksite wellness program endorsed by the North American Ski Area Association and funded by the National Cancer Institute. Between 2000 and 2002 we designed and implemented a large-scale worksite intervention at over 300 ski resorts in North America with the objective of reducing ski area employees and guests…

Applied Biomechanics Research for the United States Ski Team.

ERIC Educational Resources Information Center

Dillman, Charles J.

1982-01-01

Assisted by a team of physicians and sports scientists, the United States Ski Team has developed its own sports medicine program, the purpose of which is to assist coaches and athletes in controlling and optimizing factors which influence skiing performance. A number of biomechanical research projects which have been undertaken as part of this…

Ski areas affect Pacific marten movement, habitat use, and density

Treesearch

Keith M. Slauson; William J. Zielinski; Michael K. Schwartz

2017-01-01

Alpine ski recreation is one of the most popular outdoor winter sports globally but often involves habitat modification and dense human activity, both of which can harm wildlife. We investigated the effects of ski area development and winter recreation activities on movement, occupancy, and density of Pacific martens (Martes caurina) in the Lake...

The Evolution of Oscillatory Behavior during Learning on a Ski Simulator

ERIC Educational Resources Information Center

Teulier, Caroline; Nourrit, Deborah; Delignieres, Didier

2006-01-01

Recent experiments on the ski simulator produced ambiguous results and raised unanswered questions concerning the true nature of "novice" behavior and the occurrence of behavioral changes during learning. The aim of the present experiment was to analyze the evolving behavior of three beginners during six practice sessions on a ski simulator. The…

Axillary nerve injury associated with sports.

PubMed

Lee, Sangkook; Saetia, Kriangsak; Saha, Suparna; Kline, David G; Kim, Daniel H

2011-11-01

The aim of this retrospective study was to present and investigate axillary nerve injuries associated with sports. This study retrospectively reviewed 26 axillary nerve injuries associated with sports between the years 1985 and 2010. Preoperative status of the axillary nerve was evaluated by using the Louisiana State University Health Science Center (LSUHSC) grading system published by the senior authors. Intraoperative nerve action potential recordings were performed to check nerve conduction and assess the possibility of resection. Neurolysis, suture, and nerve grafts were used for the surgical repair of the injured nerves. In 9 patients with partial loss of function and 3 with complete loss, neurolysis based on nerve action potential recordings was the primary treatment. Two patients with complete loss of function were treated with resection and suturing and 12 with resection and nerve grafting. The minimum follow-up period was 16 months (mean 20 months). The injuries were associated with the following sports: skiing (12 cases), football (5), rugby (2), baseball (2), ice hockey (2), soccer (1), weightlifting (1), and wrestling (1). Functional recovery was excellent. Neurolysis was performed in 9 cases, resulting in an average functional recovery of LSUHSC Grade 4.2. Recovery with graft repairs averaged LSUHSC Grade 3 or better in 11 of 12 cases Surgical repair can restore useful deltoid function in patients with sports-associated axillary nerve injuries, even in cases of severe stretch-contusion injury.

In-frame mutations in exon 1 of SKI cause dominant Shprintzen-Goldberg syndrome.

PubMed

Carmignac, Virginie; Thevenon, Julien; Adès, Lesley; Callewaert, Bert; Julia, Sophie; Thauvin-Robinet, Christel; Gueneau, Lucie; Courcet, Jean-Benoit; Lopez, Estelle; Holman, Katherine; Renard, Marjolijn; Plauchu, Henri; Plessis, Ghislaine; De Backer, Julie; Child, Anne; Arno, Gavin; Duplomb, Laurence; Callier, Patrick; Aral, Bernard; Vabres, Pierre; Gigot, Nadège; Arbustini, Eloisa; Grasso, Maurizia; Robinson, Peter N; Goizet, Cyril; Baumann, Clarisse; Di Rocco, Maja; Sanchez Del Pozo, Jaime; Huet, Frédéric; Jondeau, Guillaume; Collod-Beroud, Gwenaëlle; Beroud, Christophe; Amiel, Jeanne; Cormier-Daire, Valérie; Rivière, Jean-Baptiste; Boileau, Catherine; De Paepe, Anne; Faivre, Laurence

2012-11-02

Shprintzen-Goldberg syndrome (SGS) is characterized by severe marfanoid habitus, intellectual disability, camptodactyly, typical facial dysmorphism, and craniosynostosis. Using family-based exome sequencing, we identified a dominantly inherited heterozygous in-frame deletion in exon 1 of SKI. Direct sequencing of SKI further identified one overlapping heterozygous in-frame deletion and ten heterozygous missense mutations affecting recurrent residues in 18 of the 19 individuals screened for SGS; these individuals included one family affected by somatic mosaicism. All mutations were located in a restricted area of exon 1, within the R-SMAD binding domain of SKI. No mutation was found in a cohort of 11 individuals with other marfanoid-craniosynostosis phenotypes. The interaction between SKI and Smad2/3 and Smad 4 regulates TGF-β signaling, and the pattern of anomalies in Ski-deficient mice corresponds to the clinical manifestations of SGS. These findings define SGS as a member of the family of diseases associated with the TGF-β-signaling pathway. Copyright © 2012 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylation.

PubMed

Prunier, Celine; Pessah, Marcia; Ferrand, Nathalie; Seo, Su Ryeon; Howe, Philip; Atfi, Azeddine

2003-07-11

The phosphorylation of Smad2 and Smad3 by the transforming growth factor (TGF)-beta-activated receptor kinases and their subsequent heterodimerization with Smad4 and translocation to the nucleus form the basis for a model how Smad proteins work to transmit TGF-beta signals. The transcriptional activity of Smad2-Smad4 or Smad3-Smad4 complexes can be limited by the corepressor Ski, which is believed to interact with Smad complexes on TGF-beta-responsive promoters and represses their ability to activate TGF-beta target genes by assembling on DNA a repressor complex containing histone deacetylase. Here we show that Ski can block TGF-beta signaling by interfering with the phosphorylation of Smad2 and Smad3 by the activated TGF-beta type I receptor. Furthermore, we demonstrate that overexpression of Ski induces the assembly of Smad2-Smad4 and Smad3-Smad4 complexes independent of TGF-beta signaling. The ability of Ski to engage Smad proteins in nonproductive complexes provides new insights into the molecular mechanism used by Ski for disabling TGF-beta signaling.

A microcomputer controlled snow ski binding system--I. Instrumentation and field evaluation.

PubMed

MacGregor, D; Hull, M L; Dorius, L K

1985-01-01

This paper presents the design and field evaluation of the first microcomputer controlled ski binding system. This system incorporates an Intel 8086 microcomputer controller and an integral binding/dynamometer. This instrumentation system not only undertakes real time control, but also it records dynamometer data via a miniature digital cassette tape recorder. The integral binding/dynamometer offers the same operational and mounting convenience of commercially available mechanical bindings. The binding may be released either manually or electrically via the controller. Comprised of four octagonal half strain rings, the strain gage dynamometer measures the three moment load components at the boot. To enable the user to conveniently operate the computer, extensive operating software was developed. The operating software is discussed in relation to both the acquisition and storage of data from the dynamometer and the control of the electro-mechanical snow ski binding. The binding system has been used successfully to both record boot moment components and control ski binding release during actual skiing maneuvers. Moment histories typical of three common recreational skiing maneuvers are presented.

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury

PubMed Central

Dal-Secco, Daniela; Wang, Jing; Zeng, Zhutian; Kolaczkowska, Elzbieta; Wong, Connie H.Y.; Petri, Björn; Ransohoff, Richard M.; Charo, Israel F.

2015-01-01

Monocytes are recruited from the blood to sites of inflammation, where they contribute to wound healing and tissue repair. There are at least two subsets of monocytes: classical or proinflammatory (CCR2hiCX3CR1low) and nonclassical, patrolling, or alternative (CCR2lowCX3CR1hi) monocytes. Using spinning-disk confocal intravital microscopy and mice with fluorescent reporters for each of these subsets, we were able to track the dynamic spectrum of monocytes that enter a site of sterile hepatic injury in vivo. We observed that the CCR2hiCX3CR1low monocytes were recruited early and persisted for at least 48 h, forming a ringlike structure around the injured area. These monocytes transitioned, in situ, from CCR2hiCx3CR1low to CX3CR1hiCCR2low within the ringlike structure and then entered the injury site. This phenotypic conversion was essential for optimal repair. These results demonstrate a local, cytokine driven reprogramming of classic, proinflammatory monocytes into nonclassical or alternative monocytes to facilitate proper wound-healing. PMID:25800956

MiR-34a/miR-93 target c-Ski to modulate the proliferaton of rat cardiac fibroblasts and extracellular matrix deposition in vivo and in vitro.

PubMed

Zhang, Chengliang; Zhang, Yanfeng; Zhu, Hong; Hu, Jiajia; Xie, Zhongshang

2018-06-01

Cardiac fibrosis is associated with diverse heart diseases. In response to different pathological irritants, cardiac fibroblasts may be induced to proliferate and differentiate into cardiac myofibroblasts, thus contributing to cardiac fibrosis. TGF-β signaling is implicated in the development of heart failure through the induction of cardiac fibrosis. C-Ski, an inhibitory regulator of TGF-β signaling, has been reported to suppress TGF-β1-induced human cardiac fibroblasts' proliferation and ECM protein increase; however, the underlying molecular mechanism needs further investigation. In the present study, we demonstrated that c-Ski could ameliorate isoproterenol (ISO)-induced rat myocardial fibrosis model and TGF-β1-induced primary rat cardiac fibroblasts' proliferation, as well as extracellular matrix (ECM) deposition. The protein level of c-Ski was dramatically decreased in cardiac fibrosis and TGF-β1-stimulated primary rat cardiac fibroblasts. In recent decades, a family of small non-coding RNA, namely miRNAs, has been reported to regulate gene expression by interacting with diverse mRNAs and inducing either translational suppression or mRNA degradation. Herein, we selected miR-34a and miR-93 as candidate miRNAs that might target to regulate c-Ski expression. After confirming that miR-34a/miR-93 targeted c-Ski to inhibit its expression, we also revealed that miR-34a/miR-93 affected TGF-β1-induced fibroblasts' proliferation and ECM deposition through c-Ski. Taken together, we demonstrated a miR-34a/miR-93-c-Ski axis which modulates TGF-β1- and ISO-induced cardiac fibrosis in vitro and in vivo; targeting the inhibitory factors of c-Ski to rescue its expression may be a promising strategy for the treatment of cardiac fibrosis. Copyright © 2018 Elsevier Inc. All rights reserved.

Changes in Quadriceps Muscle Activity During Sustained Recreational Alpine Skiing

PubMed Central

Kröll, Josef; Müller, Erich; Seifert, John G.; Wakeling, James M.

2011-01-01

During a day of skiing thousands of repeated contractions take place. Previous research on prolonged recreational alpine skiing show that physiological changes occur and hence some level of fatigue is inevitable. In the present paper the effect of prolonged skiing on the recruitment and coordination of the muscle activity was investigated. Six subjects performed 24 standardized runs. Muscle activity during the first two (PREskiing) and the last two (POSTskiing) runs was measured from the vastus lateralis (VL) and rectus femoris (RF) using EMG and quantified using wavelet and principal component analysis. The frequency content of the EMG signal shifted in seven out of eight cases significantly towards lower frequencies with highest effects observed for RF on outside leg. A significant pronounced outside leg loading occurred during POSTskiing and the timing of muscle activity peaks occurred more towards turn completion. Specific EMG frequency changes were observed at certain time points throughout the time windows and not over the whole double turn. It is suggested that general muscular fatigue, where additional specific muscle fibers have to be recruited due to the reduced power output of other fibers did not occur. The EMG frequency decrease and intensity changes for RF and VL are caused by altered timing (coordination) within the turn towards a most likely more uncontrolled skiing technique. Hence, these data provide evidence to suggest recreational skiers alter their skiing technique before a potential change in muscle fiber recruitment occurs. Key points The frequency content of the EMG signal shifted in seven out of eight cases significantly towards lower frequencies with highest effects observed for RF. General muscular fatigue, where additional specific fibers have to be recruited due to the reduced power output of other fibers, did not occur. A modified skiing style towards a less functional and hence more uncontrolled skiing technique seems to be a key issue with respect to the influence on muscle recruitment for applied prolonged skiing session. PMID:24149299

Performance analysis of Virginia's safety service patrol programs : a case study approach.

DOT National Transportation Integrated Search

2006-01-01

Many state departments of transportation (DOTs) operate safety service patrols (SSPs) as part of their incident management programs. The primary objectives of SSPs are to minimize the duration of freeway incidents, restore full capacity of the freewa...

Evaluation of the Washington state target zero teams project : traffic tech.

DOT National Transportation Integrated Search

2015-01-01

In late 2006, the Washington State Patrol (WSP) assembled : a full-time, high-visibility saturation patrol called the Night : Emphasis Enforcement Team (NEET). This pilot program, : based in Snohomish County and funded by the Washington : Traffic Saf...

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Science.gov Websites

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Trust Based Evaluation of Wikipedia's Contributors

NASA Astrophysics Data System (ADS)

Krupa, Yann; Vercouter, Laurent; Hübner, Jomi Fred; Herzig, Andreas

Wikipedia is an encyclopedia on which anybody can change its content. Some users, self-proclaimed "patrollers", regularly check recent changes in order to delete or correct those which are ruining articles integrity. The huge quantity of updates leads some articles to remain polluted a certain time before being corrected. In this work, we show how a multiagent trust model can help patrollers in their task of controlling the Wikipedia. To direct the patrollers verification towards suspicious contributors, our work relies on a formalisation of Castelfranchi & Falcone's social trust theory to assist them by representing their trust model in a cognitive way.

Land degradation at the Stara Planina ski resort.

PubMed

Ristić, Ratko; Kašanin-Grubin, Milica; Radić, Boris; Nikić, Zoran; Vasiljević, Nevena

2012-03-01

The environmental impacts of ski resorts in the Balkan region are great and can lead to landscape degradation and loss of land functionality. In this study, we present an example of the negative effects of human activities at the Stara Planina ski resort in southeastern Serbia. The objective of this study is detailed analysis of the characteristics of environmental impacts at the Stara Planina. The management of the ski area and ski slope development caused severe degradation of topsoil and native vegetation. The morphological characteristics of the area, lithological properties of the exposed material and climate conditions resulted in various geomorphic impacts, including rills, deep gullies, solifluctions and debris from rock weathering. Significant changes in land usage altered hydrological conditions, resulting in more frequent torrential floods in the downstream sections of the Zubska River and increased the sediment yield. Environmental impacts were analyzed in the immediate and wider zones of the ski resort in accordance with the specific topography and visual exposure. The restoration and erosion control measures have stopped degradation processes and helped to rehabilitate the appearance and functions of the landscape. The results show the importance of considering lithological (the type and characteristics of minerals present) and hydrological (precipitation, water storage capacity of soil, runoff) factors under the conditions of significant changes in land usage. The results of this investigation can contribute to the improvement of planning processes and the implementation of development projects in ski areas.

Dual role of Ski in pancreatic cancer cells: tumor-promoting versus metastasis-suppressive function.

PubMed

Wang, Peng; Chen, Zhen; Meng, Zhi-Qiang; Fan, Jie; Luo, Jian-Min; Liang, Wang; Lin, Jun-Hua; Zhou, Zhen-Hua; Chen, Hao; Wang, Kun; Shen, Ye-Hua; Xu, Zu-De; Liu, Lu-Ming

2009-09-01

Ski used to be defined as an oncogene that contributes to the resistance of tumor cells to transforming growth factor-beta (TGF-beta)-induced growth arrest. As TGF-beta has a dual effect on tumor growth with both tumor-suppressing and -promoting activity depending on the stage of carcinogenesis and the cell type, the precise role of Ski in carcinogenesis remains unclear. In this study, we show that downregulation of Ski through lentivirus-mediated RNA interference decreases tumor growth both in vitro and in vivo, yet promotes cell invasiveness in vitro, and lung metastasis in vivo in the pancreatic cancer cell line SW1990, which contain wild-type Smad4 expression, and the BxPC3 cell line, which is Smad4 deficient. We also show that the downregulation of Ski increases TGF-beta-induced transcriptional activity, which is associated with increased TGF-beta-dependent Smad2/3 phosphorylation, and results in an altered expression profile of TGF-beta-inducible genes involved in metastasis, angiogenesis and cell proliferation and epithelial-mesenchymal transition. Immunohistochemical analysis of specimens from 71 patients with pancreatic adenocarcinoma showed a significant association between overexpression of Ski and decreased patient survival time (P = 0.0024). Our results suggest that Ski may act as a tumor proliferation-promoting factor or as a metastatic suppressor in human pancreatic cancer.

Involvement of c-Ski oncoprotein in carcinogenesis of cholangiocacinoma induced by Opisthorchis viverrini and N-nitrosodimethylamine.

PubMed

Boonmars, Thidarut; Wu, Zhiliang; Boonjaruspinyo, Sirintip; Puapairoj, Anucha; Kaewsamut, Butsara; Nagano, Isao; Pinlaor, Somchai; Yongvanit, Puangrat; Wonkchalee, Orasa; Juasook, Amornrat; Sudsarn, Pakkayanee; Srisawangwong, Tuanchai

2011-06-01

Opisthorchiasis is the major public health problem in the endemic areas of Thailand and Laos because Opisthorchis viverrini infection causes serious hepatobiliary diseases including CCA. The molecular mechanism of the CCA carcinogenesis induced by the infection remains obscure. To reveal the potential genes and signaling pathways to involve in the carcinogenesis, the present study investigated the expression of c-Ski, an oncogene, and two TGF-β signaling pathway relative genes, TGF-β and Smad4, during the development of CCA induced by O. viverrini infection in hamster model, and in human opisthorchiasis associated CCA. The results showed that the expression of c-Ski gene was greatly up-regulated during the carcinogenesis of CCA in hamster model. The overexpression of c-Ski was confirmed by immunohistological staining result which showed the increased expression of c-Ski protein in cytoplasm of the epithelial lining of hepatic bile ducts. Moreover, the immunohistological staining of the specimens of human opisthorchiasis associated CCA revealed the up-regulated expression of c-Ski and Smad4 proteins in the cytoplasm of the epithelial lining of hepatic bile ducts and stomal fibrosis respectively. The expression of TGF-β and Smad4 were up-regulated, which expression kinetics was time-dependent of CCA development. These results suggest that c-Ski is likely involved in the carcinogenesis of CCA induced by O. viverrini infection through regulating TGF-β signaling pathway.

Does listening to music with an audio ski helmet impair reaction time to peripheral stimuli?

PubMed

Ruedl, G; Pocecco, E; Wolf, M; Schöpf, S; Burtscher, M; Kopp, M

2012-12-01

With the recent worldwide increase in ski helmet use, new market trends are developing, including audio helmets for listening to music while skiing or snowboarding. The aim of this study was to evaluate whether listening to music with an audio ski helmet impairs reaction time to peripheral stimuli. A within-subjects design study using the Compensatory-Tracking-Test was performed on 65 subjects (36 males and 29 females) who had a mean age of 23.3 ± 3.9 years. Using repeated measures analysis of variance, we found significant differences in reaction times between the 4 test conditions (p=0.039). The lowest mean reaction time (± SE) was measured for helmet use while listening to music (507.9 ± 13.2 ms), which was not different from helmet use alone (514.6 ± 12.5 ms) (p=0.528). However, compared to helmet use while listening to music, reaction time was significantly longer for helmet and ski goggles used together (535.8 ± 14.2 ms, p=0.005), with a similar trend for helmet and ski goggles used together while listening to music (526.9 ± 13.8 ms) (p=0.094). In conclusion, listening to music with an audio ski helmet did not increase mean reaction time to peripheral stimuli in a laboratory setting. © Georg Thieme Verlag KG Stuttgart · New York.

Enhanced UV exposure on a ski-field compared with exposures at sea level.

PubMed

Allen, Martin; McKenzie, Richard

2005-05-01

Personal erythemal UV monitoring badges, which were developed to monitor the UV exposure of school children, were used to measure UV exposures received by one of the authors (MA) at the Mt Hutt ski-field, in New Zealand. These were then compared with measurements taken at the same times from a nearby sea level site in Christchurch city. The badges were designed to give instantaneous readings of erythemally-weighted (i.e., "sun burning") UV radiation and were cross-calibrated against meteorological grade UV instruments maintained by the National Institute of Water & Atmospheric Research (NIWA). All skiing and calibration days were clear and almost exclusively cloud free. It was found that the UV maxima for horizontal surfaces at the ski-field (altitude approximately 2 km) were 20-30% greater than at the low altitude site. Larger differences between the sites were observed when the sensor was oriented perpendicular to the sun. The personal doses of UV received by a sensor on the skier's lapel during two days of skiing activity were less than those received by a stationary detector on a horizontal surface near sea level. The exposures depended strongly on the time of year, and in mid-October the maximum UV intensity on the ski-field was 60% greater than in mid-September. The UV exposure levels experienced during skiing were smaller than the summer maxima at low altitudes.

77 FR 36994 - Questa Ranger District, Carson National Forest; Taos County, NM; Taos Ski Valley's 2010 Master...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

... County, NM; Taos Ski Valley's 2010 Master Development Plan--Phase 1 Projects; Additional Filings AGENCY... environmental impact statement for a proposal to authorize several (Phase 1) projects included in the Taos Ski... (ROD) are expected in July 2012. Change in Responsible Official: In addition, this notice changes the...

Kick, Glide, Pole! Cross-Country Skiing Fun (Part II)

ERIC Educational Resources Information Center

Duoos, Bridget A.

2012-01-01

Part I of Kick, Glide, Pole! Cross-Country Skiing Fun, which was published in last issue, discussed how to select cross-country ski equipment, dress for the activity and the biomechanics of the diagonal stride. Part II focuses on teaching the diagonal stride technique and begins with a progression of indoor activities. Incorporating this fun,…

Reducing the Odds: Backcountry Powder Skiing in Avalanche Terrain.

ERIC Educational Resources Information Center

Daffern, Tony

This paper provides information and strategies to reduce the risk of encountering an avalanche when skiing or climbing on steep slopes. Skiers must recognize that the risk exists, be aware of their own tolerance for risk, and not allow companions to pressure them into taking more risk than they can tolerate. Ideally, one should ski with a small…

Sustainability of the Dissemination of an Occupational Sun Protection Program in a Randomized Trial

ERIC Educational Resources Information Center

Buller, David B.; Walkosz, Barbara J.; Andersen, Peter A.; Scott, Michael D.; Dignan, Mark B.; Cutter, Gary R.; Zhang, Xiao; Kane, Ilima L.

2012-01-01

Sustainability of an occupational sun safety program, Go Sun Smart (GSS), was explored in a randomized trial, testing dissemination strategies at 68 U.S. and Canadian ski areas in 2004-2007. All ski areas received GSS from the National Ski Areas Association through a Basic Dissemination Strategy (BDS) using conference presentations and free…

Kick, Glide, Pole! Cross-Country Skiing Fun (Part I)

ERIC Educational Resources Information Center

Duoos, Bridget A.

2011-01-01

Cross-country skiing is a great activity for taking a physical education class outside during the cold winter months. It is also a diverse activity that appeals to students of all ages, and is an excellent cardio-respiratory activity to keep students active. This article has provided the first steps in preparing a cross-country skiing lesson in…

A return on investment study of the Hampton Roads Safety Service Patrol program.

DOT National Transportation Integrated Search

2007-01-01

Safety Service Patrol (SSP) programs are widely used to help mitigate the effects of nonrecurring congestion on our nation's highways and have become an increasingly vital element of incident management programs. SSPs are typically deployed in areas ...

Melting in the Arctic: Preparing Now for Possibilities in the Future

DTIC Science & Technology

2016-04-04

shipping, exploration, research, tourism , military patrols, and unfortunately the potential for conflict. So far, climate change, diplomacy, and economic...presence such as shipping, exploration, research, tourism , military patrols, and unfortunately the potential for conflict. So far, climate change...3 Tourism

A survey of Canadian Alpine ski racing coaches regarding spinal protective devices for their athletes

PubMed Central

Stainsby, Brynne; Law, Jeremy; Mackinnon, Amy

2014-01-01

Introduction: Spinal protective devices are a recent addition to the protective equipment worn by competitive and recreational alpine skiers and snowboarders. Their rate of use is not documented at the time of publication. The objective of this study was to examine the current attitudes and recommendations of Canadian alpine ski racing coaches towards spinal protective devices. Methods: A convenience sample of alpine ski racing coaches across Canada were contacted in each provincial sport governing body in the ski racing community. A ten question online survey was attached to the initial email. Descriptive statistical analysis was utilized. Results: A total of 29 Canadian alpine ski racing coaches completed the study survey. All participants were familiar with spinal protective devices and 51.7% of respondents reported that they do not actively enforce spinal protective device use with their ski racing athletes. 80% of respondents reported that their Canadian ski racing club did not have guidelines or policies regarding spinal protective device use. 86.2% of respondents were unaware if their provincial sport organization had a policy regarding their use. Discussion: The majority of coaches reporting training athletes aged 10–15, which may help to explain why only half of those surveyed enforce the use of spinal protective devices. This group of athletes may not participate in speed events as frequently as older athletes, where the use of spinal protective devices is more common. Conclusion: The majority of Canadian Alpine ski coaches report a belief that spinal protective device use is important, however, far fewer enforce their use, or work in an environment with a policy requiring it. Further research is required to determine the differences in beliefs and practice. PMID:25550668

Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.

PubMed

Zhang, Song; Takaku, Motoki; Zou, Liyun; Gu, Ai-di; Chou, Wei-Chun; Zhang, Ge; Wu, Bing; Kong, Qing; Thomas, Seddon Y; Serody, Jonathan S; Chen, Xian; Xu, Xiaojiang; Wade, Paul A; Cook, Donald N; Ting, Jenny P Y; Wan, Yisong Y

2017-11-02

T helper 17 (T H 17) cells are critically involved in host defence, inflammation, and autoimmunity. Transforming growth factor β (TGFβ) is instrumental in T H 17 cell differentiation by cooperating with interleukin-6 (refs 6, 7). Yet, the mechanism by which TGFβ enables T H 17 cell differentiation remains elusive. Here we reveal that TGFβ enables T H 17 cell differentiation by reversing SKI-SMAD4-mediated suppression of the expression of the retinoic acid receptor (RAR)-related orphan receptor γt (RORγt). We found that, unlike wild-type T cells, SMAD4-deficient T cells differentiate into T H 17 cells in the absence of TGFβ signalling in a RORγt-dependent manner. Ectopic SMAD4 expression suppresses RORγt expression and T H 17 cell differentiation of SMAD4-deficient T cells. However, TGFβ neutralizes SMAD4-mediated suppression without affecting SMAD4 binding to the Rorc locus. Proteomic analysis revealed that SMAD4 interacts with SKI, a transcriptional repressor that is degraded upon TGFβ stimulation. SKI controls histone acetylation and deacetylation of the Rorc locus and T H 17 cell differentiation via SMAD4: ectopic SKI expression inhibits H3K9 acetylation of the Rorc locus, Rorc expression, and T H 17 cell differentiation in a SMAD4-dependent manner. Therefore, TGFβ-induced disruption of SKI reverses SKI-SMAD4-mediated suppression of RORγt to enable T H 17 cell differentiation. This study reveals a critical mechanism by which TGFβ controls T H 17 cell differentiation and uncovers the SKI-SMAD4 axis as a potential therapeutic target for treating T H 17-related diseases.

(124)I-iodopyridopyrimidinone for PET of Abl kinase-expressing tumors in vivo.

PubMed

Doubrovin, Mikhail; Kochetkova, Tatiana; Santos, Elmer; Veach, Darren R; Smith-Jones, Peter; Pillarsetty, Nagavarakishore; Balatoni, Julius; Bornmann, William; Gelovani, Juri; Larson, Steven M

2010-01-01

Because of the recent development of an iodopyridopyrimidinone Abl protein kinase inhibitor (PKI), (124)I-SKI-212230 ((124)I-SKI230), we investigated the feasibility of a PET-based molecular imaging method for the direct visualization of Abl kinase expression and PKI treatment. In vitro pharmacokinetic properties, including specific and nonspecific binding of (124)I-SKI230 to its Abl kinase target and interaction with other PKIs, were assessed in cell-free medium and chronic myelogenous leukemia (CML) cells overexpressing BCR-Abl (K562), in comparison with BT-474 cells that are low in Abl expression. In a xenograft tumor model, we assessed the in vivo pharmacokinetics of (124)I-SKI230 using PET and postmortem tissue sampling. We also tested a paradigm of (124)I-SKI230 PET after treatment of the animal with a dose of Abl-specific PKI for the monitoring of the tumor response. In vitro studies confirmed that SKI230 binds to Abl kinase with nanomolar affinity, that selective uptake occurs in cell lines known to express Abl kinase, that RNAi knock-down supports specificity of cellular uptake due to Abl kinase, and that imatinib, an archetype Abl PKI, completely displaces SKI230. With SKI230, we obtained successful in vivo PET of Abl-expressing human tumors in a nude rat. We were also able to demonstrate evidence of substrate inhibition of in vivo radiotracer uptake in the xenograft tumor after treatment of the animal as a model of PKI treatment monitoring. These results support the hypothesis that molecular imaging using PET will be useful for the study of in vivo pharmacodynamics of Abl PKI molecular therapy in humans.

Calcium, magnesium, and phosphorus metabolism, and parathyroid-calcitonin function during prolonged exposure to elevated CO2 concentrations on submarines.

PubMed

Messier, A A; Heyder, E; Braithwaite, W R; McCluggage, C; Peck, A; Schaefer, K E

1979-01-01

Studies of calcium and phosphorus metabolism and acid-base balance were carried out on three Fleet Ballistic Missile (FBM) submarines during prolonged exposure to elevated concentrations of CO2. The average CO2 concentration in the submarine atmosphere during patrols ranged from 0.85% to 1% CO2. In the three studies, in which 9--15 subjects participated, the urinary excretion of calcium and phosphate fell during the first three weeks to a level commensurate with a decrease in plasma calcium and increase in phosphorus. In the fourth week of one patrol, a marked increase was found in urinary calcium excretion, associated with a rise in blood PCO2 and bicarbonate. Urinary calcium excretion decreased again during the 5th to 8th week, with a secondary decrease in blood pH and plasma calcium. During the third patrol, the time course of acid-base changes corresponded well with that found during the second patrol. There was a trend toward an increase in plasma calcium between the fourth and fifth week commensurate with the transient rise in pH and bicarbonate. Plasma parathyroid and calcitonin hormone activities were measured in two patrols and no significant changes were found. Hydroxyproline excretion decreased in the three-week study and remained unchanged in the second patrol, which lasted 57 days. It is suggested that during prolonged exposure to low levels of CO2 (up to 1% CO2), calcium metabolism is controlled by the uptake and release of CO2 in the bones. The resulting phases in bone buffering, rather than renal regulation, determine acid-base balance.

Goodyear aerospace conceptual design maritime patrol airship ZP3G. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, N.D.

1979-04-01

A Conceptual design of a modern technology airship with precision hover capability for use in maritime patrol is described. The size and major characteristics are established by a series of United States Coast Guard missions set forth by the contracting agency.

Change detection on UGV patrols with respect to a reference tour using VIS imagery

NASA Astrophysics Data System (ADS)

Müller, Thomas

2015-05-01

Autonomous driving robots (UGVs, Unmanned Ground Vehicles) equipped with visual-optical (VIS) cameras offer a high potential to automatically detect suspicious occurrences and dangerous or threatening situations on patrol. In order to explore this potential, the scene of interest is recorded first on a reference tour representing the 'everything okay' situation. On further patrols changes are detected with respect to the reference in a two step processing scheme. In the first step, an image retrieval is done to find the reference images that are closest to the current camera image on patrol. This is done efficiently based on precalculated image-to-image registrations of the reference by optimizing image overlap in a local reference search (after a global search when that is needed). In the second step, a robust spatio-temporal change detection is performed that widely compensates 3-D parallax according to variations of the camera position. Various results document the performance of the presented approach.

76 FR 31800 - Airworthiness Directives; Viking Air Limited Model DHC-3 (Otter) Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

...: ``Airspeed limitation: VMO = 144 MPH for the effective date of this land/ski plane and VMO = 134 MPH for... limit for land/ in-service (TIS) after the ski plane and 134 MPH, VMO speed limit for seaplane... land/ski the effective date of this plane and/or with a red radial at 134 MPH for a seaplane. This...

[Role of Ski/SnoN protein in the regulation of TGF-beta signal pathway].

PubMed

Lu, Zhao-hui; Chen, Jie

2003-04-01

TGF-beta signal pathway plays an important role in the cell growth, differentiation, formation of extracellular matrix, embryo development and carcinogenesis, etc. However, the regulation of TGF-beta pathway is not totally understood. In 1999, three independent research groups found that Ski/SnoN protein could inhibit the TGF-beta mediated transcription by recruiting N-CoR, a transcription co-repressor. Later studies suggested that TGF-beta and SMADs degraded the Ski/SnoN protein by mediating ubiquitin linkage, showing negative feedback regulation. The important findings in Ski/SnoN laid the theoretical foundation for demonstrating the function of TGF-beta signal pathway.

Skiing economy and efficiency in recreational and elite cross-country skiers.

PubMed

Ainegren, Mats; Carlsson, Peter; Tinnsten, Mats; Laaksonen, Marko S

2013-05-01

The purpose of this study was to investigate and compare skiing economy and gross efficiency in cross-country skiers of different performance levels, ages and genders; male recreational skiers and elite senior and junior cross-country skiers of both genders. The skiers performed tests involving roller skiing on a treadmill using the gear 3 and diagonal stride techniques. The elite cross-country skiers were found to have better skiing economy and higher gross efficiency (5-18%) compared with the recreational skiers (p < 0.05) and the senior elite had better economy and higher efficiency (4-5%) than their junior counterparts (p < 0.05), whereas no differences could be found between the genders. Also, large ranges in economy and gross efficiency were found in all groups. It was concluded that, in addition to V[Combining Dot Above]O2peak, skiing economy and gross efficiency have a great influence on the differences in performance times between recreational and junior and senior elite cross-country skiers, as well as between individual skiers within the different categories. Thus, we recommend cross-country skiers at all performance levels to test not only V[Combining Dot Above]O2peak, but also skiing economy and efficiency.

Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.

PubMed

Arndt, Stephanie; Poser, Ina; Moser, Markus; Bosserhoff, Anja-Katrin

2007-04-01

The Ski family of nuclear oncoproteins represses transforming growth factor-beta (TGF-beta) signaling through inhibition of transcriptional activity of Smad proteins. In this study, we identified a novel gene, fussel-15 (functional smad suppressing element on chromosome 15) with high homology to the recently discovered Fussel-18 protein. Both, Fussel-15 and Fussel-18, share important structural features, significant homology and similar genomic organization with the homolog Ski family members, Ski and SnoN. Unlike Ski and SnoN, which are ubiquitously expressed in human tissues, Fussel-15 expression, like Fussel-18, is much more restricted in its expression and is principally found in the nervous system of mouse and humans. Interestingly, Fussel-15 expression is even more restricted in adulthood to Purkinje cells of human cerebellum. In contrast to Fussel-18 that interacts with Smad 2, Smad3 and Smad4 and has an inhibitory activity on TGF-beta signaling, Fussel-15 interacts with Smad1, Smad2 and Smad3 molecules and suppresses mainly BMP signaling pathway but has only minor effects on TGF-beta signaling. This new protein expands the family of Ski/Sno proto-oncoproteins and represents a novel molecular regulator of BMP signaling.

Cardiovascular and thermal strain during 3-4 days of a metabolically demanding cold-weather military operation.

PubMed

Castellani, John W; Spitz, Marissa G; Karis, Anthony J; Martini, Svein; Young, Andrew J; Margolis, Lee M; Phillip Karl, J; Murphy, Nancy E; Xu, Xiaojiang; Montain, Scott J; Bohn, Jamie A; Teien, Hilde K; Stenberg, Pål H; Gundersen, Yngvar; Pasiakos, Stefan M

2017-01-01

Cardiovascular (CV) and thermal responses to metabolically demanding multi-day military operations in extreme cold-weather environments are not well described. Characterization of these operations will provide greater insights into possible performance capabilities and cold injury risk. Soldiers from two cold-weather field training exercises (FTX) were studied during 3-day (study 1, n  = 18, age: 20 ± 1 year, height: 182 ± 7 cm, mass: 82 ± 9 kg) and 4-day (study 2, n  = 10, age: 20 ± 1 year, height: 182 ± 6 cm, mass: 80.7 ± 8.3 kg) ski marches in the Arctic. Ambient temperature ranged from -18 to -4 °C during both studies. Total daily energy expenditure (TDEE, from doubly labeled water), heart rate (HR), deep body ( T pill ), and torso ( T torso ) skin temperature (obtained in studies 1 and 2) as well as finger ( T fing ), toe ( T toe ), wrist, and calf temperatures (study 2) were measured. TDEE was 6821 ± 578 kcal day -1 and 6394 ± 544 for study 1 and study 2, respectively. Mean HR ranged from 120 to 140 bpm and mean T pill ranged between 37.5 and 38.0 °C during skiing in both studies. At rest, mean T pill ranged from 36.0 to 36.5 °C, (lowest value recorded was 35.5 °C). Mean T fing ranged from 32 to 35 °C during exercise and dropped to 15 °C during rest, with some T fing values as low as 6-10 °C. T toe was above 30 °C during skiing but dropped to 15-20 °C during rest. Daily energy expenditures were among the highest observed for a military training exercise, with moderate exercise intensity levels (~65% age-predicted maximal HR) observed. The short-term cold-weather training did not elicit high CV and T pill strain. T fing and T toe were also well maintained while skiing, but decreased to values associated with thermal discomfort at rest.

Practical results from a mathematical analysis of guard patrols

DOE Office of Scientific and Technical Information (OSTI.GOV)

Indusi, Joseph P.

1978-12-01

Using guard patrols as a primary detection mechanism is not generally viewed as a highly efficient detection method when compared to electronic means. Many factors such as visibility, alertness, and the space-time coincidence of guard and adversary presence all have an effect on the probability of detection. Mathematical analysis of the guard patrol detection problem is related to that of classical search theory originally developed for naval search operations. The results of this analysis tend to support the current practice of using guard forces to assess and respond to previously detected intrusions and not as the primary detection mechanism. 6more » refs.« less

A reappraisal of success factors for Olympic cross-country skiing.

PubMed

Sandbakk, Øyvind; Holmberg, Hans-Christer

2014-01-01

Cross-country (XC) skiing has been an Olympic event since the first Winter Games in Chamonix, France, in 1924. Due to more effective training and tremendous improvements in equipment and track preparation, the speed of Olympic XC-ski races has increased more than that of any other Olympic endurance sport. Moreover, pursuit, mass-start, and sprint races have been introduced. Indeed, 10 of the 12 current Olympic competitions in XC skiing involve mass starts, in which tactics play a major role and the outcome is often decided in the final sprint. Accordingly, reappraisal of the success factors for performance in this context is required. The very high aerobic capacity (VO2max) of many of today's world-class skiers is similar that of their predecessors. At the same time, the new events provide more opportunities to profit from anaerobic capacity, upper-body power, high-speed techniques, and "tactical flexibility." The wide range of speeds and slopes involved in XC skiing requires skiers to continuously alternate between and adapt different subtechniques during a race. This technical complexity places a premium on efficiency. The relative amounts of endurance training performed at different levels of intensity have remained essentially constant during the past 4 decades. However, in preparation for the Sochi Olympics in 2014, XC skiers are performing more endurance training on roller skis on competition-specific terrain, placing greater focus on upper-body power and more systematically performing strength training and skiing at high speeds than previously.

Are Ski and SnoN Involved in the Tumorigenesis of Oral Squamous Cell Carcinoma Through Smad4?

PubMed

Alaeddini, Mojgan; Etemad-Moghadam, Shahroo

2018-05-04

Transforming growth factor-β has been implicated in the tumorigenesis of oral squamous cell carcinoma (OSCC). Ski and SnoN are negative regulators of transforming growth factor-β/Smad pathway with both prooncogenic and antioncogenic functions in different cancers. The aim of this study was to assess the expression of Ski and SnoN in OSCC for the first time. Smad4 was also evaluated in these tumors. Clinical data on 61 primary OSCCs were gathered, and the specimens were subjected to immunohistochemical staining with monoclonal antibodies against SKI, SnoN, and Smad4 and scored semiquantitatively. Spearman rank, Fisher exact, and χ tests were used for statistical analysis, and P-value <0.05 was considered significant. Ski positivity and SnoN positivity were mostly cytoplasmic and found in 96.7% and 100% of the cases, respectively. Smad4 staining was low to negative in 65% of the specimens. No significant relationship was found either among the markers or between each of the proteins and the clinicopathologic data (P>0.05). According to our findings, Ski, SnoN, and Smad4 seem to play a role in OSCC oncogenesis, and we suggest that Ski and SnoN functions may take place independent of Smad4. Considering the dual and complex role of these proteins in tumorigenesis, further investigation to clarify the molecular pathways involved in their mode of action is suggested.

Confronting the demand and supply of snow seasonal forecasts for ski resorts : the case of French Alps

NASA Astrophysics Data System (ADS)

Dubois, Ghislain

2017-04-01

Alpine ski resorts are highly dependent on snow, which availability is characterized by a both a high inter-annual variability and a gradual diminution due to climate change. Due to this dependency to climatic resources, the ski industry is increasingly affected by climate change: higher temperatures limit snow falls, increase melting and limit the possibilities of technical snow making. Therefore, since the seventies, managers drastically improved their practices, both to adapt to climate change and to this inter-annual variability of snow conditions. Through slope preparation and maintenance, snow stock management, artificial snow making, a typical resort can approximately keep the same season duration with 30% less snow. The ski industry became an activity of high technicity The EUPORIAS FP7 (www.euporias.eu) project developed between 2012 and 2016 a deep understanding of the supply and demand conditions for the provision of climate services disseminating seasonal forecasts. In particular, we developed a case study, which allowed conducting several activities for a better understanding of the demand and of the business model of future services applied to the ski industry. The investigations conducted in France inventoried the existing tools and databases, assessed the decision making process and data needs of ski operators, and provided evidences that some discernable skill of seasonal forecasts exist. This case study formed the basis of the recently funded PROSNOW H2020 project. We will present the main results of EUPORIAS project for the ski industry.

A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease.

PubMed

Oppliger, Joel; da Palma, Joel Ramos; Burri, Dominique J; Bergeron, Eric; Khatib, Abdel-Majid; Spiropoulou, Christina F; Pasquato, Antonella; Kunz, Stefan

2016-01-15

Arenaviruses are emerging viruses including several causative agents of severe hemorrhagic fevers in humans. The advent of next-generation sequencing technology has greatly accelerated the discovery of novel arenavirus species. However, for many of these viruses, only genetic information is available, and their zoonotic disease potential remains unknown. During the arenavirus life cycle, processing of the viral envelope glycoprotein precursor (GPC) by the cellular subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P) is crucial for productive infection. The ability of newly emerging arenaviruses to hijack human SKI-1/S1P appears, therefore, to be a requirement for efficient zoonotic transmission and human disease potential. Here we implement a newly developed cell-based molecular sensor for SKI-1/S1P to characterize the processing of arenavirus GPC-derived target sequences by human SKI-1/S1P in a quantitative manner. We show that only nine amino acids flanking the putative cleavage site are necessary and sufficient to accurately recapitulate the efficiency and subcellular location of arenavirus GPC processing. In a proof of concept, our sensor correctly predicts efficient processing of the GPC of the newly emergent pathogenic Lujo virus by human SKI-1/S1P and defines the exact cleavage site. Lastly, we employed our sensor to show efficient GPC processing of a panel of pathogenic and nonpathogenic New World arenaviruses, suggesting that GPC cleavage represents no barrier for zoonotic transmission of these pathogens. Our SKI-1/S1P sensor thus represents a rapid and robust test system for assessment of the processing of putative cleavage sites derived from the GPCs of newly discovered arenavirus by the SKI-1/S1P of humans or any other species, based solely on sequence information. Arenaviruses are important emerging human pathogens that can cause severe hemorrhagic fevers with high mortality in humans. A crucial step in productive arenavirus infection of human cells is the processing of the viral envelope glycoprotein by the cellular subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P). In order to break the species barrier during zoonotic transmission and cause severe disease in humans, newly emerging arenaviruses must be able to hijack human SKI-1/S1P efficiently. Here we implement a newly developed cell-based molecular sensor for human SKI-1/S1P to characterize the processing of arenavirus glycoproteins in a quantitative manner. We further use our sensor to correctly predict efficient processing of the glycoprotein of the newly emergent pathogenic Lujo virus by human SKI-1/S1P. Our sensor thus represents a rapid and robust test system with which to assess whether the glycoprotein of any newly emerging arenavirus can be efficiently processed by human SKI-1/S1P, based solely on sequence information. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Using satellite communications for a mobile computer network

NASA Technical Reports Server (NTRS)

Wyman, Douglas J.

1993-01-01

The topics discussed include the following: patrol car automation, mobile computer network, network requirements, network design overview, MCN mobile network software, MCN hub operation, mobile satellite software, hub satellite software, the benefits of patrol car automation, the benefits of satellite mobile computing, and national law enforcement satellite.

Employment of Personnel at the Tucson Border Patrol Station

DTIC Science & Technology

2017-06-09

RESEARCH METHODOLOGY How should the Tucson Border Patrol Station optimally employ personnel? Using a case study research methodology141 provided...BORSTAR provide better capabilities to respond and greater mobility in risk management.155 The methodologies of case study comparatives include the...35 CHAPTER 3 RESEARCH METHODOLOGY

Cardiometabolic Health in Submariners Returning from a 3-Month Patrol

PubMed Central

Gasier, Heath G.; Young, Colin R.; Gaffney-Stomberg, Erin; McAdams, Douglas C.; Lutz, Laura J.; McClung, James P.

2016-01-01

Confined space, limited exercise equipment, rotating shift work and reduced sleep may affect cardiometabolic health in submariners. To test this hypothesis, 53 male U.S. Submariners (20–39 years) were studied before and after a 3-month routine submarine patrol. Measures included anthropometrics, dietary and physical activity, biomarkers of cardiometabolic health, energy and appetite regulation, and inflammation. Before deployment, 62% of submariners had a body fat % (BF%) ≥ 25% (obesity), and of this group, 30% met the criteria for metabolic syndrome. In obese volunteers, insulin, the homeostatic model assessment of insulin resistance (HOMA-IR), leptin, the leptin/adiponectin ratio, and pro-inflammatory chemokines growth-related oncogene and macrophage-derived chemokine were significantly higher compared to non-obese submariners. Following the patrol, a significant mean reduction in body mass (5%) and fat-mass (11%) occurred in the obese group as a result of reduced energy intake (~2000 kJ) during the patrol; and, independent of group, modest improvements in serum lipids and a mean reduction in interferon γ-induced protein 10 and monocyte chemotactic protein 1 were observed. Since 43% of the submariners remained obese, and 18% continued to meet the criteria for metabolic syndrome following the patrol, the magnitude of weight loss was insufficient to completely abolish metabolic dysfunction. Submergence up to 3-months, however, does not appear to be the cause of obesity, which is similar to that of the general population. PMID:26867201

Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols

PubMed Central

Holy, Xavier; Bégot, Laurent; Renault, Sylvie; Butigieg, Xavier; André, Catherine; Bonneau, Dominique; Savourey, Gustave; Collombet, Jean-Marc

2015-01-01

Within the framework of earlier publications, we have consistently dedicated our investigations to eliciting the effects of both seasonal vitamin D deficiency and submarine-induced hypercapnia on serum parameters for acid–base balance and bone metabolism in submariners over a 2-month winter (WP) or summer (SP) patrols. The latest findings reported herein, contribute further evidence with regard to overall physiological regulations in the same submariner populations that underwent past scrutiny. Hence, urine and blood samples were collected in WP and SP submariners at control prepatrol time as well as on submarine patrol days 20, 41, and 58. Several urine and serum metabolic markers were quantified, namely, deoxypyridinoline (DPD), lactate, albumin, creatinine, nonesterified fatty acids (NEFA), and ionized sodium (Na+) or potassium (K+), with a view to assessing bone, muscle, liver, or kidney metabolisms. We evidenced bone metabolism alteration (urine DPD, calcium, and phosphorus) previously recorded in submarine crewmembers under prolonged patrols. We also highlighted transitory modifications in liver metabolism (serum albumin) occurring within the first 20 days of submersion. We further evidenced changes in submariners’ renal physiology (serum creatinine) throughout the entire patrol time span. Measurements of ionic homeostasis (serum Na+ and K+) displayed potential seasonal impact over active ionic pumps in submariners. Finally, there is some evidence that submersion provides beneficial conditions prone to fend off seasonal lactic acidosis (serum lactate) detected in WP submariners. PMID:26265754

The use of computer graphics in the visual analysis of the proposed Sunshine Ski Area expansion

Treesearch

Mark Angelo

1979-01-01

This paper describes the use of computer graphics in designing part of the Sunshine Ski Area in Banff National Park. The program used was capable of generating perspective landscape drawings from a number of different viewpoints. This allowed managers to predict, and subsequently reduce, the adverse visual impacts of ski-run development. Computer graphics have proven,...

The Effects of Short-Term Ski Trainings on Dynamic Balance Performance and Vertical Jump in Adolescents

ERIC Educational Resources Information Center

Camliguney, Asiye Filiz

2013-01-01

Skiing is a sport where balance and strength are critical and which can be practiced actively especially from early years to old age. The purpose of this study is to examine the effect of a 5-day training of skiing skills on dynamic balance performance and development of vertical jump strength in adolescents. Sixteen adolescent volunteers who do…

Factors that Influence the Performance of Elite Sprint Cross-Country Skiers.

PubMed

Hébert-Losier, Kim; Zinner, Christoph; Platt, Simon; Stöggl, Thomas; Holmberg, Hans-Christer

2017-02-01

Sprint events in cross-country skiing are unique not only with respect to their length (0.8-1.8 km), but also in involving four high-intensity heats of ~3 min in duration, separated by a relatively short recovery period (15-60 min). Our aim was to systematically review the scientific literature to identify factors related to the performance of elite sprint cross-country skiers. Four electronic databases were searched using relevant medical subject headings and keywords, as were reference lists, relevant journals, and key authors in the field. Only original research articles addressing physiology, biomechanics, anthropometry, or neuromuscular characteristics and elite sprint cross-country skiers and performance outcomes were included. All articles meeting inclusion criteria were quality assessed. Data were extracted from each article using a standardized form and subsequently summarized. Thirty-one articles met the criteria for inclusion, were reviewed, and scored an average of 66 ± 7 % (range 56-78 %) upon quality assessment. All articles except for two were quasi-experimental, and only one had a fully-experimental research design. In total, articles comprised 567 subjects (74 % male), with only nine articles explicitly reporting their skiers' sprint International Skiing Federation points (weighted mean 116 ± 78). A similar number of articles addressed skating and classical techniques, with more than half of the investigations involving roller-skiing assessments under laboratory conditions. A range of physiological, biomechanical, anthropometric, and neuromuscular characteristics was reported to relate to sprint skiing performance. Both aerobic and anaerobic capacities are important qualities, with the anaerobic system suggested to contribute more to the performance during the first of repeated heats; and the aerobic system during subsequent heats. A capacity for high speed in all the following instances is important for the performance of sprint cross-country skiers: at the start of the race, at any given point when required (e.g., when being challenged by a competitor), and in the final section of each heat. Although high skiing speed is suggested to rely primarily on high cycle rates, longer cycle lengths are commonly observed in faster skiers. In addition, faster skiers rely on different technical strategies when approaching peak speeds, employ more effective techniques, and use better coordinated movements to optimize generation of propulsive force from the resultant ski and pole forces. Strong uphill technique is critical to race performance since uphill segments are the most influential on race outcomes. A certain strength level is required, although more does not necessarily translate to superior sprint skiing performance, and sufficient strength-endurance capacities are also of importance to minimize the impact and accumulation of fatigue during repeated heats. Lastly, higher lean mass does appear to benefit sprint skiers' performance, with no clear advantage conferred via body height and mass. Generalization of findings from one study to the next is challenging considering the array of experimental tasks, variables defining performance, fundamental differences between skiing techniques, and evolution of sprint skiing competitions. Although laboratory-based measures can effectively assess on-snow skiing performance, conclusions drawn from roller-skiing investigations might not fully apply to on-snow skiing performance. A low number of subjects were females (only 17 %), warranting further studies to better understand this population. Lastly, more training studies involving high-level elite sprint skiers and investigations pertaining to the ability of skiers to maintain high-sprint speeds at the end of races are recommended to assist in understanding and improving high-level sprint skiing performance, and resilience to fatigue. Successful sprint cross-country skiing involves well-developed aerobic and anaerobic capacities, high speed abilities, effective biomechanical techniques, and the ability to develop high forces rapidly. A certain level of strength is required, particularly ski-specific strength, as well as the ability to withstand fatigue across the repeated heats of sprint races. Cross-country sprint skiing is demonstrably a demanding and complex sport, where high-performance skiers need to simultaneously address physiological, biomechanical, anthropometric, and neuromuscular aspects to ensure success.

Cyber-Cops: Angels on the Net.

ERIC Educational Resources Information Center

Educom Review, 1996

1996-01-01

Curtis Sliwa, founder of the Guardian Angels citizens' safety patrol, discusses the development of the Cyber Angels, an online citizens' patrol group that monitors Internet communication. Cyber Angels voluntarily look for and report any illegal activity conducted over the Internet, such as pyramid scams, transmission of stolen credit card and…

Identification of core functions and development of a deployment planning tool for safety service patrols in Virginia.

DOT National Transportation Integrated Search

2006-01-01

The purpose of this study was to identify and document the core functions of the Virginia Department of Transportation's (VDOT) Safety Service Patrol (SSP) programs and to develop a deployment planning tool that would help VDOT decision-makers when c...

EXPOSURE TO PARTICULATE MATTER, VOLATILE ORGANIC COMPOUNDS, AND OTHER AIR POLLUTANTS INSIDE PATROL CARS

EPA Science Inventory

People driving in a vehicle might receive an enhanced dose of mobile source pollutants that are considered a potential risk for cardiovascular diseases. The exposure to components of air pollution in highway patrol vehicles, at an ambient, and a roadside location was determined d...

Pediatric trauma in the Austrian Alps: the epidemiology of sport-related injuries in helicopter emergency medical service.

PubMed

Selig, Harald F; Hüpfl, Michael; Trimmel, Helmut; Voelckel, Wolfgang G; Nagele, Peter

2012-06-01

We aimed to examine the epidemiological characteristics and injury patterns of pediatric trauma in helicopter emergency medical service (HEMS) caused by sports/outdoor activities in alpine environment. This retrospective cohort study analyzed 912 primary HEMS missions for pediatric trauma (0-14 years of age) in Austrian Alps between 1 January 2006 and 30 June 2007. Children were stratified by age into toddlers (3-5 years), children in early (6-9 years), and late school age (10-14 years). The majority of pediatric sports-related trauma in alpine environment was caused by skiing (82.1%; n=749). Pediatric patients were predominately in late school age and boys (72.8%, n=664 and 61.0%, n=556, respectively) and a minority (16.0%, n=146) was severely injured. Overall, fracture (47.0%, n=429), contusion (17.9%, n=163), and traumatic brain injury (17.0%, n=155) were the most common prehospital diagnoses. The most frequent pattern of injury was related to the head/face and spine (36.3%, n=331). The knowledge about epidemiological characteristics of HEMS use for injured children in alpine environment may be essential for training requirements of HEMS crews and operational considerations of HEMS providers. The incidence of head and spinal injuries requires support for initiatives to promote helmet wear and appropriate risk behavior amongst skiers and snowboarders.

The Effect of 12 Weeks of Ski Training on Some Biometric Features of Girls

ERIC Educational Resources Information Center

Tas, Murat; Kiyici, Elif; Kiyci, Fatih

2018-01-01

The aim of this study was to investigate the effect of skiing on the biomotoric characteristics of children with evaluating tests of girls between the ages of eight and 14 before and after the season. The experimental group of this study was 15 girls who had just started skiing and the control group of 30 girls. In total, 45 volunteers joined the…

Simulation Model of Mobile Detection Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Edmunds, T; Faissol, D; Yao, Y

2009-01-27

In this paper, we consider a mobile source that we attempt to detect with man-portable, vehicle-mounted or boat-mounted radiation detectors. The source is assumed to transit an area populated with these mobile detectors, and the objective is to detect the source before it reaches a perimeter. We describe a simulation model developed to estimate the probability that one of the mobile detectors will come in to close proximity of the moving source and detect it. We illustrate with a maritime simulation example. Our simulation takes place in a 10 km by 5 km rectangular bay patrolled by boats equipped withmore » 2-inch x 4-inch x 16-inch NaI detectors. Boats to be inspected enter the bay and randomly proceed to one of seven harbors on the shore. A source-bearing boat enters the mouth of the bay and proceeds to a pier on the opposite side. We wish to determine the probability that the source is detected and its range from target when detected. Patrol boats select the nearest in-bound boat for inspection and initiate an intercept course. Once within an operational range for the detection system, a detection algorithm is started. If the patrol boat confirms the source is not present, it selects the next nearest boat for inspection. Each run of the simulation ends either when a patrol successfully detects a source or when the source reaches its target. Several statistical detection algorithms have been implemented in the simulation model. First, a simple k-sigma algorithm, which alarms with the counts in a time window exceeds the mean background plus k times the standard deviation of background, is available to the user. The time window used is optimized with respect to the signal-to-background ratio for that range and relative speed. Second, a sequential probability ratio test [Wald 1947] is available, and configured in this simulation with a target false positive probability of 0.001 and false negative probability of 0.1. This test is utilized when the mobile detector maintains a constant range to the vessel being inspected. Finally, a variation of the sequential probability ratio test that is more appropriate when source and detector are not at constant range is available [Nelson 2005]. Each patrol boat in the fleet can be assigned a particular zone of the bay, or all boats can be assigned to monitor the entire bay. Boats assigned to a zone will only intercept and inspect other boats when they enter their zone. In our example simulation, each of two patrol boats operate in a 5 km by 5 km zone. Other parameters for this example include: (1) Detection range - 15 m range maintained between patrol boat and inspected boat; (2) Inbound boat arrival rate - Poisson process with mean arrival rate of 30 boats per hour; (3) Speed of boats to be inspected - Random between 4.5 and 9 knots; (4) Patrol boat speed - 10 knots; (5) Number of detectors per patrol boat - 4-2-inch x 4-inch x 16-inch NaI detectors; (6) Background radiation - 40 counts/sec per detector; and (7) Detector response due to radiation source at 1 meter - 1,589 counts/sec per detector. Simulation results indicate that two patrol boats are able to detect the source 81% of the time without zones and 90% of the time with zones. The average distances between the source and target at the end of the simulation is 5,866 km and 5,712 km for non-zoned and zoned patrols, respectively. Of those that did not reach the target, the average distance to the target is 7,305 km and 6,441 km respectively. Note that a design trade-off exists. While zoned patrols provide a higher probability of detection, the nonzoned patrols tend to detect the source farther from its target. Figure 1 displays the location of the source at the end of 1,000 simulations for the 5 x 10 km bay simulation. The simulation model and analysis described here can be used to determine the number of mobile detectors one would need to deploy in order to have a have reasonable chance of detecting a source in transit. By fixing the source speed to zero, the same model could be used to estimate how long it would take to detect a stationary source. For example, the model could predict how long it would take plant staff performing assigned duties carrying dosimeters to discover a contaminated spot in the facility.« less

Kinematics and Kinetics of Squats, Drop Jumps and Imitation Jumps of Ski Jumpers.

PubMed

Pauli, Carole A; Keller, Melanie; Ammann, Fabian; Hübner, Klaus; Lindorfer, Julia; Taylor, William R; Lorenzetti, Silvio

2016-03-01

Squats, drop jumps, and imitation jumps are commonly used training exercises in ski jumping to enhance maximum force, explosive force, and sport-specific skills. The purpose of this study was to evaluate the kinetics and kinematics of training exercises in ski jumping and to find objective parameters in training exercises that most correlate with the competition performance of ski jumpers. To this end, barbell squats, drop jumps, and imitation jumps were measured in a laboratory environment for 10 elite ski jumpers. Force and motion data were captured, and the influence of maximum vertical force, force difference, vertical take-off velocity, knee moments, knee joint power, and a knee valgus/varus index was evaluated and correlated with their season jump performance. The results indicate that, especially for the imitation jumps, a good correlation exists between the vertical take-off velocity and the personal jump performance on the hill (R = 0.718). Importantly, however, the more the athletes tended toward a valgus knee alignment during the measured movements, the worse their performance (R = 0.729 imitation jumps; R = 0.685 squats). Although an evaluation of the athletes' lower limb alignment during competitive jumping on the hill is still required, these preliminary data suggest that performance training should additionally concentrate on improving knee alignment to increase ski jumping performance.

The Current State of Head and Neck Injuries in Extreme Sports

PubMed Central

Sharma, Vinay K.; Rango, Juan; Connaughton, Alexander J.; Lombardo, Daniel J.; Sabesan, Vani J.

2015-01-01

Background: Since their conception during the mid-1970s, international participation in extreme sports has grown rapidly. The recent death of extreme snowmobiler Caleb Moore at the 2013 Winter X Games has demonstrated the serious risks associated with these sports. Purpose: To examine the incidence and prevalence of head and neck injuries (HNIs) in extreme sports. Study Design: Descriptive epidemiological study. Methods: The National Electronic Injury Surveillance System (NEISS) was used to acquire data from 7 sports (2000-2011) that were included in the Winter and Summer X Games. Data from the NEISS database were collected for each individual sport per year and type of HNI. Cumulative data for overall incidence and injuries over the entire 11-year period were calculated. National estimates were determined using NEISS-weighted calculations. Incidence rates were calculated for extreme sports using data from Outdoor Foundation Participation Reports. Results: Over 4 million injuries were reported between 2000 and 2011, of which 11.3% were HNIs. Of all HNIs, 83% were head injuries and 17% neck injuries. The 4 sports with the highest total incidence of HNI were skateboarding (129,600), snowboarding (97,527), skiing (83,313), and motocross (78,236). Severe HNI (cervical or skull fracture) accounted for 2.5% of extreme sports HNIs. Of these, skateboarding had the highest percentage of severe HNIs. Conclusion: The number of serious injuries suffered in extreme sports has increased as participation in the sports continues to grow. A greater awareness of the dangers associated with these sports offers an opportunity for sports medicine and orthopaedic physicians to advocate for safer equipment, improved on-site medical care, and further research regarding extreme sports injuries. PMID:26535369

Balance, Basic Anthropometrics and Performance in Young Alpine Skiers; Longitudinal Analysis of the Associations During two Competitive Seasons

PubMed Central

Lesnik, Blaz; Sekulic, Damir; Supej, Matej; Esco, Michael R; Zvan, Milan

2017-01-01

Abstract Balance is hypothesized to be important in alpine skiing, while it is known that balance depends on anthropometric indices. The aim of this investigation was to explore the association between balance, anthropometrics and skiing-results over two competitive seasons among youth alpine-skiers. Eighty-one skiers (40 females) participated in this study. The participants were tested twice over two competitive seasons: when they were 12-13 years old (U14) and when they were 14-15 years old (U16). The variables consisted of anthropometrics (body height and body mass) and three balance indexes (medio-lateral-, anterio-posterior- and overall-stability-index). Additionally, skiing results in U14 and U16 were evaluated. The balance status did not change significantly over the observed period of time regardless of the significant changes in body mass and height. The relationships between balance and skiing results were higher in the U14 (Pearson’s r = 0.45-0.54) than in the U16 (Pearson’s r = 0.05-0.28). The relationships between anthropometrics and competitive results were generally stronger in girls (Pearson’s r = 0.39-0.88) than in boys (Pearson’s r = 0.26-0.58). After clustering athletes into three achievement groups on a basis of their competitive performance, discriminant canonical analysis showed that relationships between balance and skiing results decreased, while the relationships between anthropometrics and skiing results increased over the two observed seasons. This study highlighted the importance of balance in youth alpine skiing in the age range of 11-14 years. PMID:28713454

Balance, Basic Anthropometrics and Performance in Young Alpine Skiers; Longitudinal Analysis of the Associations During two Competitive Seasons.

PubMed

Lesnik, Blaz; Sekulic, Damir; Supej, Matej; Esco, Michael R; Zvan, Milan

2017-06-01

Balance is hypothesized to be important in alpine skiing, while it is known that balance depends on anthropometric indices. The aim of this investigation was to explore the association between balance, anthropometrics and skiing-results over two competitive seasons among youth alpine-skiers. Eighty-one skiers (40 females) participated in this study. The participants were tested twice over two competitive seasons: when they were 12-13 years old (U14) and when they were 14-15 years old (U16). The variables consisted of anthropometrics (body height and body mass) and three balance indexes (medio-lateral-, anterio-posterior- and overall-stability-index). Additionally, skiing results in U14 and U16 were evaluated. The balance status did not change significantly over the observed period of time regardless of the significant changes in body mass and height. The relationships between balance and skiing results were higher in the U14 (Pearson's r = 0.45-0.54) than in the U16 (Pearson's r = 0.05-0.28). The relationships between anthropometrics and competitive results were generally stronger in girls (Pearson's r = 0.39-0.88) than in boys (Pearson's r = 0.26-0.58). After clustering athletes into three achievement groups on a basis of their competitive performance, discriminant canonical analysis showed that relationships between balance and skiing results decreased, while the relationships between anthropometrics and skiing results increased over the two observed seasons. This study highlighted the importance of balance in youth alpine skiing in the age range of 11-14 years.

Stretch-shortening cycle in roller ski skating: effects of technique.

PubMed

Perrey, S; Millet, G Y; Candau, R; Rouillon, J D

1998-11-01

The purposes of this study were 1) to examine the occurrence of the stretch-shortening cycle (SSC) in the three principal techniques of ski skating and 2) to test the hypothesis that differences in SSC behaviour may explain the choice of a technique when the grade is altered. Ten highly skilled male cross-country skiers roller skied at 5.3+/-0.1 m x s(-1) using the V1 skate (V1), V2-alternate (V2A), and V2 skate (V2) techniques. Knee and ankle joint kinematics, EMG of the vastus lateralis (VL) and gastrocnemius lateralis (GL) muscles, and roller ski velocity were recorded during the last 40 s of each bout of roller skiing. The existence of an EMG signal during the eccentric phase prior to the thrust, as well as the lack of significant delay between the two phases, showed that SSC occurs in the three techniques of roller ski skating with the exception of 50% of the subjects at the weak side knee with V1. The VL stretching velocity over the eccentric phase was higher (p < 0.005) with V2 and V2A than V1, indicating that less elastic energy was stored in the lower limbs extensor muscles with V1. This could partly explain why this technique is not used on flat terrains during races. However, no differences of average EMG activity or IEMG existed between techniques for either GL or VL during the concentric phase, suggesting that the theoretical advantage due to the SSC behaviour is minor in roller ski skating.

Kinematics and Kinetics of Squats, Drop Jumps and Imitation Jumps of Ski Jumpers

PubMed Central

Pauli, Carole A.; Keller, Melanie; Ammann, Fabian; Hübner, Klaus; Lindorfer, Julia; Taylor, William R.

2016-01-01

Abstract Pauli, CA, Keller, M, Ammann, F, Hübner, K, Lindorfer, J, Taylor, WR, and Lorenzetti, S. Kinematics and kinetics of squats, drop jumps and imitation jumps of ski jumpers. J Strength Cond Res 30(3): 643–652, 2016—Squats, drop jumps, and imitation jumps are commonly used training exercises in ski jumping to enhance maximum force, explosive force, and sport-specific skills. The purpose of this study was to evaluate the kinetics and kinematics of training exercises in ski jumping and to find objective parameters in training exercises that most correlate with the competition performance of ski jumpers. To this end, barbell squats, drop jumps, and imitation jumps were measured in a laboratory environment for 10 elite ski jumpers. Force and motion data were captured, and the influence of maximum vertical force, force difference, vertical take-off velocity, knee moments, knee joint power, and a knee valgus/varus index was evaluated and correlated with their season jump performance. The results indicate that, especially for the imitation jumps, a good correlation exists between the vertical take-off velocity and the personal jump performance on the hill (R = 0.718). Importantly, however, the more the athletes tended toward a valgus knee alignment during the measured movements, the worse their performance (R = 0.729 imitation jumps; R = 0.685 squats). Although an evaluation of the athletes' lower limb alignment during competitive jumping on the hill is still required, these preliminary data suggest that performance training should additionally concentrate on improving knee alignment to increase ski jumping performance. PMID:26418370

Yeast RNA viruses as indicators of exosome activity: human exosome hCsl4p participates in RNA degradation in Saccharomyces cerevisiae'.

PubMed

Ramírez-Garrastacho, Manuel; Esteban, Rosa

2011-12-01

The exosome is an evolutionarily conserved 10-mer complex involved in RNA metabolism, located in both the nucleus and the cytoplasm. The cytoplasmic exosome plays an important role in mRNA turnover through its 3'→5' exonucleolytic activity. The superkiller (SKI) phenotype of yeast was originally identified as an increase of killer toxin production due to elevated levels of the L-A double-stranded RNA (dsRNA) Totivirus and its satellite toxin-encoding M dsRNA. Most SKI genes were later shown to be either components of the exosome or modulators of its activity. Variations in the amount of Totivirus are, thus, good indicators of yeast exosome activity, and can be used to analyse its components. Furthermore, if exosome proteins of higher eukaryotes were functional in S. cerevisiae, these viruses would provide a simple tool to analyse their function. In this work, we have found that hCSL4, the human orthologue of SKI4 in the yeast exosome, rescues the null phenotype of the deletion mutant. hCsl4p shares with Ski4p conserved S1 RNA-binding domains, but lacks the N-terminal third of Ski4p. Nevertheless, it interacts with the Dis3p exonuclease of yeast exosome, and partially complements the superkiller phenotype of ski4-1 mutation. The elimination of the N-terminal third of Ski4p does not affect its activity, indicating that it is dispensable for RNA degradation. We have also identified the point mutation G152E in hCSL4, equivalent to the ski4-1 mutation G253E, which impairs the activity of the protein, thus validating our approach of using yeast RNA virus to analyse the exosome of higher eukaryotes. Copyright © 2011 John Wiley & Sons, Ltd.

DOE Office of Scientific and Technical Information (OSTI.GOV)

English, P.B.; Shaw, G.M.; Windham, G.C.

Highway patrol officers are the primary responders to hazardous material spills in California, yet little is known regarding the health effects resulting from this exposure. A historical cohort study of 993 California highway patrol officers who responded to hazardous material spills in 1984 was conducted. The records of officers who were exposed to acutely toxic chemicals were followed for the subsequent week to determine if they demonstrated more absenteeism or illness compared to officers who were not exposed to toxic chemicals. No significant differences in the frequency of absenteeism or illness was found between the two groups during the weekmore » following exposure. No indication was found that exposure to hazardous materials during a highway patrol spill response results in increased absenteeism.« less

In depth review of the 1979 AIAA Lighter-Than-Air Systems Technology Conference

NASA Technical Reports Server (NTRS)

Ardema, M. D.

1979-01-01

The lighter than air (LTA) systems technology conference is reviewed. Highlights of the conference were: (1) the interest shown in patrol and surveillance airships, particularly for coastal patrol missions; (2) the session devoted to overviews of foreign activity; and (3) heavy lift and long range transport aircraft design considerations.

CHANGES IN LUNG FUNCTION OBSERVED IN A STUDY OF PM AND AIR TOXICS EXPOSURE TO NC HIGHWAY PATROL TROOPERS (COPP-STUDY)

EPA Science Inventory

Introduction: Car emissions have been identified as a major source of respirable particles. Individuals whose jobs involve being on the road, such as patrol troopers, may be exposed to high cencentrations of toxic air pollutants from vehicle emissions. This exposure might a...

An analysis of arthropod interceptions by APHIS-PPQ and Customs and Border Patrol in Puerto Rico

USDA-ARS?s Scientific Manuscript database

USDA Animal Plant Health Inspection Service Plant Protection and Quarantine (APHIS-PPQ) and Customs and Border Patrol (CBP) inspect traffic entering the United States for arthropods that pose a threat to national agriculture and/or ecosystems. We analyzed interceptions made by these agencies in Puer...

RxPATROL: a Web-based tool for combating pharmacy theft.

PubMed

Smith, Meredith Y; Graham, J Aaron; Haddox, J David; Steffey, Amy

2009-01-01

To report the incidence of pharmacy-related burglaries and robberies and characteristics of pharmacies where such crimes have occurred using recent data from Rx Pattern Analysis Tracking Robberies & Other Losses (RxPATROL), a national Web-based information clearinghouse on pharmacy-related theft of prescription medications and over-the-counter products. Descriptive, nonexperimental study. United States between 2005 and 2006. Not applicable. Not applicable. Number of pharmacy theft reports received; incident type, date, and location; point of entry; and pharmacy security features. Between 2005 and 2006, 202 pharmacy burglary and 299 pharmacy robbery reports from 45 different states were filed with RxPATROL. More than 70% of pharmacies reporting such crimes lacked a security camera. Among those reporting a burglary, 60% lacked dead bolt locks, a solid exterior door, a motion detector device, or a safe or vault for storage of controlled substances. Burglars most often obtained access to the pharmacy via the front door. RxPATROL is a Web-based tool that can assist pharmacies and law enforcement in collaborating more effectively to combat and prevent pharmacy-related crimes.

Separation of variables in Maxwell equations in Plebański-Demiański spacetime

NASA Astrophysics Data System (ADS)

Frolov, Valeri P.; Krtouš, Pavel; KubizÅák, David

2018-05-01

A new method for separating variables in the Maxwell equations in four- and higher-dimensional Kerr-(A)dS spacetimes proposed recently by Lunin is generalized to any off-shell metric that admits a principal Killing-Yano tensor. The key observation is that Lunin's ansatz for the vector potential can be formulated in a covariant form—in terms of the principal tensor. In particular, focusing on the four-dimensional case we demonstrate separability of Maxwell's equations in the Kerr-NUT-(A)dS and the Plebański-Demiański family of spacetimes. The new method of separation of variables is quite different from the standard approach based on the Newman-Penrose formalism.

Sports injuries and illnesses during the 2015 Winter European Youth Olympic Festival.

PubMed

Ruedl, G; Schnitzer, M; Kirschner, W; Spiegel, R; Platzgummer, H; Kopp, M; Burtscher, M; Pocecco, E

2016-05-01

The prevention of injury and illness remains an important issue among young elite athletes. Systematic surveillance of injuries and illnesses during multi-sport events might provide a valuable basis to develop preventive measures, focusing especially on adequate information for youth athletes. To analyse the frequencies and characteristics of injuries and illnesses during the 2015 Winter European Youth Olympic Festival (W-EYOF). All National Olympic Committees were asked to report daily the occurrence or non-occurrence of newly sustained injuries and illnesses on a standardised reporting form. Among the 899 registered athletes (37% female) with a mean age of 17.1±0.8 years, a total of 38 injuries and 34 illnesses during the 5 competition days of the W-EYOF were reported, resulting in an incidence of 42.3 injuries and 37.8 illnesses per 1000 athletes, respectively. Injury frequency was highest in snowboard cross (11%), Nordic combined (9%), alpine skiing (6%), and ice hockey (6%), taking into account the respective number of registered athletes. In snowboard cross, females showed a significant higher injury frequency compared to males (22% vs 4%, p=0.033). The lower back (16%), the pelvis (13%), the knee (11%), and the face (11%) were the most common injury locations. About 58% of injuries occurred in competition and about 42% in training. In total, 42% of injuries resulted in an absence of training or competition. The prevalence of illness was highest in figure skating (10%) and Nordic combined (9%), and the respiratory system was affected most often (53%). Four per cent of the athletes suffered from an injury and 4% from illnesses during the 2015 W-EYOF, which is about twofold lower compared to the first Winter Youth Olympic Games in 2012. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

The Uses and Impacts of Mobile Computing Technology in Hot Spots Policing.

PubMed

Koper, Christopher S; Lum, Cynthia; Hibdon, Julie

2015-12-01

Recent technological advances have much potential for improving police performance, but there has been little research testing whether they have made police more effective in reducing crime. To study the uses and crime control impacts of mobile computing technology in the context of geographically focused "hot spots" patrols. An experiment was conducted using 18 crime hot spots in a suburban jurisdiction. Nine of these locations were randomly selected to receive additional patrols over 11 weeks. Researchers studied officers' use of mobile information technology (IT) during the patrols using activity logs and interviews. Nonrandomized subgroup and multivariate analyses were employed to determine if and how the effects of the patrols varied based on these patterns. Officers used mobile computing technology primarily for surveillance and enforcement (e.g., checking automobile license plates and running checks on people during traffic stops and field interviews), and they noted both advantages and disadvantages to its use. Officers did not often use technology for strategic problem-solving and crime prevention. Given sufficient (but modest) dosages, the extra patrols reduced crime at the hot spots, but this effect was smaller in places where officers made greater use of technology. Basic applications of mobile computing may have little if any direct, measurable impact on officers' ability to reduce crime in the field. Greater training and emphasis on strategic uses of IT for problem-solving and crime prevention, and greater attention to its behavioral effects on officers, might enhance its application for crime reduction. © The Author(s) 2016.

Microsensors for border patrol applications

NASA Astrophysics Data System (ADS)

Falkofske, Dwight; Krantz, Brian; Shimazu, Ron; Berglund, Victor

2005-05-01

A top concern in homeland security efforts is the lack of ability to monitor the thousands of miles of open border with our neighbors. It is not currently feasible to continually monitor the borders for illegal intrusions. The MicroSensor System (MSS) seeks to achieve a low-cost monitoring solution that can be efficiently deployed for border patrol applications. The modifications and issues regarding the unique requirements of this application will be discussed and presented. The MicroSensor System was developed by the Defense Microelectronics Activity (DMEA) for military applications, but border patrol applications, with their unique sensor requirements, demand careful adaptation and modification from the military application. Adaptation of the existing sensor design for border applications has been initiated. Coverage issues, communications needs, and other requirements need to be explored for the border patrol application. Currently, border patrol has a number of deficiencies that can be addressed with a microsensor network. First, a distributed networked sensor field could mitigate the porous border intruder detection problem. Second, a unified database needs to be available to identify aliens attempting to cross into the United States. This database needs to take unique characteristics (e.g. biometrics, fingerprints) recovered from a specialized field unit to reliably identify intruders. Finally, this sensor network needs to provide a communication ability to allow border patrol officers to have quick access to intrusion information as well as equipment tracking and voice communication. MSS already addresses the sensing portion of the solution, including detection of acoustic, infrared, magnetic, and seismic events. MSS also includes a low-power networking protocol to lengthen the battery life. In addition to current military requirements, MSS needs a solar panel solution to extend its battery life to 5 years, and an additional backbone communication link. Expanding the capabilities of MSS will go a long way to improving the security of the nation's porous borders.

Risk factors for dermatitis in submariners during a submerged patrol: an observational cohort study.

PubMed

Flaxman, Amy; Allen, Elizabeth; Lindemann, Claudia; Yamaguchi, Yuko; O'Shea, Matthew K; Fallowfield, Joanne L; Lindsay, Michael; Gunner, Frances; Knox, Kyle; Wyllie, David H

2016-06-02

The aim of this pilot study was to determine risk factors, including Staphylococcus aureus nasal carriage, for dermatitis in submariners during a submarine patrol. 36 submariners undertaking a submerged 6-week patrol participated in the study. Severity of dermatitis and its impact was assessed using visual analogue scales and questionnaires at baseline and weekly throughout the patrol. S. aureus carriage levels in submariners were determined by nasal swabbing at baseline and shortly before disembarking the submarine. Occurrence of any skin or soft tissue infections (SSTI) were reported to the medical officer and swabs of the area were taken for subsequent analysis. S. aureus carriers were significantly more likely than non-carriers to have previously received treatment for a cutaneous abscess (39% vs 5%, OR=13 (95% CI 1.3 to 130)) with a trend to being submariners longer (p=0.051). Skin scores at baseline and on patrol were not significantly associated with carriage status. Higher dermatitis scores were observed in those who had been submariners longer (p=0.045). Smoking and allergies were not found to be linked to carriage status or skin health score in this cohort. This small pilot study investigates S. aureus carriage status and skin health in submariners. Length of submarine service but not S. aureus carriage was identified as a risk factor for worsening skin health in this small cohort during a 6-week patrol. This does not support S. aureus decolonisation to improve skin health in this population. Further investigation into causes of dermatitis in submariners is required. This data supports a better understanding of the potential impact of exposure to environmental factors that could affect skin health in submariners. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Are ranger patrols effective in reducing poaching-related threats within protected areas?

USGS Publications Warehouse

Moore, Jennnifer F.; Mulindahabi, Felix; Masozera, Michel K.; Nichols, James; Hines, James; Turikunkiko, Ezechiel; Oli, Madan K.

2018-01-01

Poaching is one of the greatest threats to wildlife conservation world-wide. However, the spatial and temporal patterns of poaching activities within protected areas, and the effectiveness of ranger patrols and ranger posts in mitigating these threats, are relatively unknown.We used 10 years (2006–2015) of ranger-based monitoring data and dynamic multi-season occupancy models to quantify poaching-related threats, to examine factors influencing the spatio-temporal dynamics of these threats and to test the efficiency of management actions to combat poaching in Nyungwe National Park (NNP), Rwanda.The probability of occurrence of poaching-related threats was highest at lower elevations (1,801–2,200 m), especially in areas that were close to roads and tourist trails; conversely, occurrence probability was lowest at high elevation sites (2,601–3,000 m), and near the park boundary and ranger posts. The number of ranger patrols substantially increased the probability that poaching-related threats disappear at a site if threats were originally present (i.e. probability of extinction of threats). Without ranger visits, the annual probability of extinction of poaching-related threats was an estimated 7%; this probability would increase to 20% and 57% with 20 and 50 ranger visits per year, respectively.Our results suggest that poaching-related threats can be effectively reduced in NNP by adding ranger posts in areas where they do not currently exist, and by increasing the number of patrols to sites where the probability of poaching activities is high.Synthesis and applications. Our application of dynamic occupancy models to predict the probability of presence of poaching-related threats is novel, and explicitly considers imperfect detection of illegal activities. Based on the modelled relationships, we identify areas that are most vulnerable to poaching, and offer insights regarding how ranger patrols can be optimally deployed to reduce poaching-related threats and other illegal activites, while taking into account potential sampling biases. We show that poaching can be effectively reduced by increasing ranger patrols to areas under high risk of poaching activities, and by adding ranger patrols near these sites. These findings are broadly applicable to national parks and protected areas experiencing a high degree of poaching and other illegal activities.

Multi-Axis Prosthetic Knee Resembles Alpine Skiing Movements of an Intact Leg

PubMed Central

Demšar, Ivan; Duhovnik, Jože; Lešnik, Blaž; Supej, Matej

2015-01-01

The purpose of the study was to analyse the flexion angles of the ski boot, ankle and knee joints of an above-knee prosthesis and to compare them with an intact leg and a control group of skiers. One subject with an above-knee amputation of the right leg and eight healthy subjects simulated the movement of a skiing turn by performing two-leg squats in laboratory conditions. By adding additional loads in proportion to body weight (BW; +1/3 BW, +2/3 BW, +3/3 BW), various skiing regimes were simulated. Change of Flexion Angle (CoFA) and Range of Motion (RoM) in the ski boot, ankle and knee joints were calculated and compared. An average RoM in the skiing boot on the side of prosthesis (4.4 ± 1.1°) was significantly lower compared to an intact leg (5.9 ± 1.8°) and the control group (6.5 ± 2.3°). In the ankle joint, the average RoM was determined to be 13.2±2.9° in the prosthesis, 12.7 ± 2.8° in an intact leg and 14.8±3.6 in the control group. However, the RoM of the knee joint in the prosthesis (42.2 ± 4.2°) was significantly larger than that of the intact leg (34.7 ± 4.4°). The average RoM of the knee joint in the control group was 47.8 ± 5.4°. The influences of additional loads on the kinematics of the lower extremities were different on the side of the prosthesis and on the intact leg. In contrast, additional loads did not produce any significant differences in the control group. Although different CoFAs in the ski boot, ankle and knee joints were used, an above-knee prosthesis with a built-in multi-axis prosthetic knee enables comparable leg kinematics in simulated alpine skiing. Key points The RoM in the ski boot on the side of the prosthetic leg was smaller than the RoM of the intact leg and the control group of healthy subjects. The RoM in the ankle joint of prosthetic leg was comparable to that of the intact leg and the control group of healthy subjects. The RoM in the prosthetic knee joint was greater than the RoM in the knee joint of the intact leg and smaller than that of the control group. The total knee flexions in the laboratory measurements were comparable with field measurements. Additional load affects the RoM of the ski boot, ankle and knee joints for the amputated skier in both legs. No significant influence from the additional load was found on the RoM in the control group of healthy subjects. The above-knee prosthesis with a multiple-axis prosthetic knee reproduces the alpine skiing kinematics of an intact leg. PMID:26664282

Psychological skills training of an elite wheelchair water-skiing athlete: a single-case study.

PubMed

de Bressy de Guast, Virginie; Golby, Jim; Van Wersch, Anna; d'Arripe-Longueville, Fabienne

2013-10-01

This study presents a complete psychological skills training (PST) program with a wheelchair athlete and examines the program effectiveness using a mixed-method approach. After initial testing, the athlete followed a two-month program of self-confidence building, motivational, visualization/relaxation, and injury management techniques. Quantitative and qualitative methods were used to examine the impacts on performance and psychological abilities. The triangulated results suggest that the PST program was perceived as effective by the athlete in terms of his sporting performances and mental skills. The characteristics and implications of a PST program with this wheelchair athlete are discussed, as well as the study limitations and the perspectives for future research.

NFI-Ski interactions mediate transforming growth factor beta modulation of human papillomavirus type 16 early gene expression.

PubMed

Baldwin, Amy; Pirisi, Lucia; Creek, Kim E

2004-04-01

Human papillomaviruses (HPVs) are present in virtually all cervical cancers. An important step in the development of malignant disease, including cervical cancer, involves a loss of sensitivity to transforming growth factor beta (TGF-beta). HPV type 16 (HPV16) early gene expression, including that of the E6 and E7 oncoprotein genes, is under the control of the upstream regulatory region (URR), and E6 and E7 expression in HPV16-immortalized human epithelial cells is inhibited at the transcriptional level by TGF-beta. While the URR contains a myriad of transcription factor binding sites, including seven binding sites for nuclear factor I (NFI), the specific sequences within the URR or the transcription factors responsible for TGF-beta modulation of the URR remain unknown. To identify potential transcription factors and binding sites involved in TGF-beta modulation of the URR, we performed DNase I footprint analysis on the HPV16 URR using nuclear extracts from TGF-beta-sensitive HPV16-immortalized human keratinocytes (HKc/HPV16) treated with and without TGF-beta. Differentially protected regions were found to be located around NFI binding sites. Electrophoretic mobility shift assays, using the NFI binding sites as probes, showed decreased binding upon TGF-beta treatment. This decrease in binding was not due to reduced NFI protein or NFI mRNA levels. Mutational analysis of individual and multiple NFI binding sites in the URR defined their role in TGF-beta sensitivity of the promoter. Overexpression of the NFI family members in HKc/HPV16 decreased the ability of TGF-beta to inhibit the URR. Since the oncoprotein Ski has been shown to interact with and increase the transcriptional activity of NFI and since cellular Ski levels are decreased by TGF-beta treatment, we explored the possibility that Ski may provide a link between TGF-beta signaling and NFI activity. Anti-NFI antibodies coimmunoprecipitated endogenous Ski in nuclear extracts from HKc/HPV16, confirming that NFI and Ski interact in these cells. Ski levels dramatically decreased upon TGF-beta treatment of HKc/HPV16, and overexpression of Ski eliminated the ability of TGF-beta to inhibit the URR. Based on these studies, we propose that TGF-beta inhibition of HPV16 early gene expression is mediated by a decrease in Ski levels, which in turn dramatically reduces NFI activity.

[Mountain biking : Breezy ups and traumatic downs].

PubMed

Schueller, G

2010-05-01

For more than two decades the popularity of mountain biking as a national pastime as well as a competitive sport has been undiminished. However, its related risks are not monitored as closely as those, for example, of skiing. The injuries caused by mountain biking are specific and cannot be compared with those caused by other cycling sports. This is due not only to the characteristics of the terrain but also to the readiness to assume a higher risk compared to cycle racing.The particular value of radiology is in the acute trauma setting. Most often musculoskeletal lesions must be examined and digital radiography and MRI are the most useful techniques. Severe trauma of the cranium, face, spine, thorax and abdomen are primarily evaluated with CT, particularly in dedicated trauma centers. Therefore, radiology can play a role in the rapid diagnosis and optimal treatment of the trauma-related injuries of mountain biking. Thus, the unnecessarily high economical damage associated with mountain biking can be avoided.

Lift mechanics of downhill skiing and snowboarding.

PubMed

Wu, Qianhong; Igci, Yesim; Andreopoulos, Yiannis; Weinbaum, Sheldon

2006-06-01

This study is conducted to develop a simplified mathematical model to describe the lift mechanics of downhill skiing and snowboarding, where the lift contributions due to both the transiently trapped air and the compressed solid phase (snow crystals) are determined. To our knowledge, this is the first time that anyone has attempted to realistically estimate the relative contribution of the transiently trapped air to the total lift in skiing and snowboarding. The model uses Shimizu's empirical relation to predict the local variation in Darcy permeability due to the compression of the solid phase. The forces and moments on the skier or snowboarder are used to predict the angle of attack of the planing surface, the penetration depth at the leading edge, and the shift in the center of pressure for two typical snow types, fresh and wind-packed snow. We present numerical solutions for snowboarding and asymptotic analytic solutions for skiing for the case where there are no edging or turning maneuvers. The force and moment balance are then used to develop a theory for control and stability in response to changes in the center of mass as the individual shifts his/her weight. Our model predicts that for fine-grained, windpacked snow that when the velocity (U) of the snowboarder or skier is 20 m.s, approximately 50% of the total lift force is generated by the trapped air for snowboarding and 40% for skiing. For highly permeable fresh powder snow, the lift contribution from the pore air pressure drops substantially. This paper develops a new theoretical framework for analyzing the lift mechanics and stability of skis and snowboards that could have important applications in future ski and snowboard design.

The physiological and biomechanical contributions of poling to roller ski skating.

PubMed

Sandbakk, Øyvind; Ettema, Gertjan; Holmberg, Hans-Christer

2013-08-01

Poling is considered to make a significant contribution to cross-country skiing with the skating technique. To better understand this contribution, the current investigation compared roller ski skating on a treadmill with the so-called G3 skating technique with (G3-P) and without poling (G3-NP). Seven male elite skiers performed 5-min submaximal tests at 8, 12, and 15 km h(-1), as well as an incremental test to exhaustion with both techniques on a 5 % incline. Ventilatory variables were assessed by open-circuit indirect calorimetry and three-dimensional kinematics analyzed using the Qualisys Pro Reflex system. G3-P was associated with approximately 15 % higher peak velocity and 10 % higher peak oxygen uptake than G3-NP in the incremental test (both P < 0.01). All ventilatory variables, as well as heart rate and blood lactate concentration were lower with G3-P as compared to G3-NP at 12 and 15 km h(-1) (all P < 0.01). Gross efficiency (i.e., the ratio of work rate to metabolic rate) at 12 km h(-1) was higher in G3-P (14.9 %) than G3-NP (13.5 %) (P < 0.01). Moreover, with G3-P cycle time and length were both 30 % longer, with correspondingly reduced cycle rates (all P < 0.01). In addition, the ski gliding and swing phases were longer and the angle between the skis smaller with G3-P (both P < 0.01), whereas the push-off time was independent of technique and velocity. Taken together, these results indicate that poling makes an important contribution to propulsion and velocity during ski skating, specifically by enhancing peak oxygen uptake, skiing efficiency and associated biomechanical variables.

Effects of winter military training on energy balance, whole-body protein balance, muscle damage, soreness, and physical performance.

PubMed

Margolis, Lee M; Murphy, Nancy E; Martini, Svein; Spitz, Marissa G; Thrane, Ingjerd; McGraw, Susan M; Blatny, Janet-Martha; Castellani, John W; Rood, Jennifer C; Young, Andrew J; Montain, Scott J; Gundersen, Yngvar; Pasiakos, Stefan M

2014-12-01

Physiological consequences of winter military operations are not well described. This study examined Norwegian soldiers (n = 21 males) participating in a physically demanding winter training program to evaluate whether short-term military training alters energy and whole-body protein balance, muscle damage, soreness, and performance. Energy expenditure (D2(18)O) and intake were measured daily, and postabsorptive whole-body protein turnover ([(15)N]-glycine), muscle damage, soreness, and performance (vertical jump) were assessed at baseline, following a 4-day, military task training phase (MTT) and after a 3-day, 54-km ski march (SKI). Energy intake (kcal·day(-1)) increased (P < 0.01) from (mean ± SD (95% confidence interval)) 3098 ± 236 (2985, 3212) during MTT to 3461 ± 586 (3178, 3743) during SKI, while protein (g·kg(-1)·day(-1)) intake remained constant (MTT, 1.59 ± 0.33 (1.51, 1.66); and SKI, 1.71 ± 0.55 (1.58, 1.85)). Energy expenditure increased (P < 0.05) during SKI (6851 ± 562 (6580, 7122)) compared with MTT (5480 ± 389 (5293, 5668)) and exceeded energy intake. Protein flux, synthesis, and breakdown were all increased (P < 0.05) 24%, 18%, and 27%, respectively, during SKI compared with baseline and MTT. Whole-body protein balance was lower (P < 0.05) during SKI (-1.41 ± 1.11 (-1.98, -0.84) g·kg(-1)·10 h) than MTT and baseline. Muscle damage and soreness increased and performance decreased progressively (P < 0.05). The physiological consequences observed during short-term winter military training provide the basis for future studies to evaluate nutritional strategies that attenuate protein loss and sustain performance during severe energy deficits.

Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.

PubMed

Reyes-Gordillo, Karina; Shah, Ruchi; Arellanes-Robledo, Jaime; Hernández-Nazara, Zamira; Rincón-Sánchez, Ana Rosa; Inagaki, Yutaka; Rojkind, Marcos; Lakshman, M Raj

2014-05-01

Alcohol-induced liver fibrosis and eventually cirrhosis is a leading cause of death. Acetaldehyde, the first metabolite of ethanol, up-regulates expression of the human α2(I) collagen gene (COL1A2). Early acetaldehyde-mediated effects involve phosphorylation and nuclear translocation of SMAD3/4-containing complexes that bind to COL1A2 promoter to induce fibrogenesis. We used human and mouse hepatic stellate cells to elucidate the mechanisms whereby acetaldehyde up-regulates COL1A2 by modulating the role of Ski and the expression of SMADs 3, 4, and 7. Acetaldehyde induced up-regulation of COL1A2 by 3.5-fold, with concomitant increases in the mRNA (threefold) and protein (4.2- and 3.5-fold) levels of SMAD3 and SMAD4, respectively. It also caused a 60% decrease in SMAD7 expression. Ski, a member of the Ski/Sno oncogene family, is colocalized in the nucleus with SMAD4. Acetaldehyde induces translocation of Ski and SMAD4 to the cytoplasm, where Ski undergoes proteasomal degradation, as confirmed by the ability of the proteasomal inhibitor lactacystin to blunt up-regulation of acetaldehyde-dependent COL1A2, but not of the nonspecific fibronectin gene (FN1). We conclude that acetaldehyde up-regulates COL1A2 by enhancing expression of the transactivators SMAD3 and SMAD4 while inhibiting the repressor SMAD7, along with promoting Ski translocation from the nucleus to cytoplasm. We speculate that drugs that prevent proteasomal degradation of repressors targeting COL1A2 may have antifibrogenic properties. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

[Doctor's degree thesis of Tomasz Adolf Wołkowiński "Carditidis rheumaticae historia"].

PubMed

Stembrowicz, W

2001-01-01

In 1817 on the University of Vilnius Faculty of Medicine, T. A. Wołkowiński, a student of the eminent clinician Józef Frank, defended his doctor's degree thesis about a direct relation between rheumatic disease and cardiomegaly. It was probably the first paper in Poland describing with details the rheumatic heart disease. Unfortunately we don't know much about T. A. Wołkowiński's life.

SKI2 mediates degradation of RISC 5′-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis

PubMed Central

Branscheid, Anja; Marchais, Antonin; Schott, Gregory; Lange, Heike; Gagliardi, Dominique; Andersen, Stig Uggerhøj; Voinnet, Olivier; Brodersen, Peter

2015-01-01

Small regulatory RNAs are fundamental in eukaryotic and prokaryotic gene regulation. In plants, an important element of post-transcriptional control is effected by 20–24 nt microRNAs (miRNAs) and short interfering RNAs (siRNAs) bound to the ARGONAUTE1 (AGO1) protein in an RNA induced silencing complex (RISC). AGO1 may cleave target mRNAs with small RNA complementarity, but the fate of the resulting cleavage fragments remains incompletely understood. Here, we show that SKI2, SKI3 and SKI8, subunits of a cytoplasmic cofactor of the RNA exosome, are required for degradation of RISC 5′, but not 3′-cleavage fragments in Arabidopsis. In the absence of SKI2 activity, many miRNA targets produce siRNAs via the RNA-dependent RNA polymerase 6 (RDR6) pathway. These siRNAs are low-abundant, and map close to the cleavage site. In most cases, siRNAs were produced 5′ to the cleavage site, but several examples of 3′-spreading were also identified. These observations suggest that siRNAs do not simply derive from RDR6 action on stable 5′-cleavage fragments and hence that SKI2 has a direct role in limiting secondary siRNA production in addition to its function in mediating degradation of 5′-cleavage fragments. PMID:26464441

The ERK/CREB pathway is involved in the c-Ski expression induced by low TGF-β1 concentrations during primary fibroblast proliferation.

PubMed

Li, Ping; Liu, Ping; Peng, Yan; Zhang, Zhuo-Hang; Li, Xiao-Ming; Xiong, Ren-Ping; Chen, Xing; Zhao, Yan; Ning, Ya-Lei; Yang, Nan; Zhang, Bo; Zhou, Yuan-Guo

2018-06-27

Increasing evidence has suggested that bidirectional regulation of cell proliferation is one important effect of TGF-β1 in wound healing. Increased c-Ski expression plays a role in promoting fibroblast proliferation at low TGF-β1 concentrations, but the mechanism by which low TGF-β1 concentrations regulate c-Ski levels remains unclear. In this study, the proliferation of rat primary fibroblasts was assessed with an ELISA BrdU kit. The mRNA and protein expression and phosphorylation levels of corresponding factors were measured by RT-qPCR, immunohistochemistry or Western blotting. We first found that low TGF-β1 concentrations not only promoted c-Ski mRNA and protein expression in rat primary fibroblasts but also increased the phosphorylation levels of Extracellular Signal-Regulated Kinases (ERK) and cAMP response element binding (CREB) protein. An ERK kinase (mitogen-activated protein kinase kinase, MEK) inhibitor significantly inhibited ERK1/2 phosphorylation levels, markedly reducing c-Ski expression and CREB phosphorylation levels and abrogating the growth-promoting effect of low TGF-β1 concentrations. At the same time, Smad2/3 phosphorylation levels were not significantly changed. Taken together, these results suggest that the increased cell proliferation induced by low TGF-β1 concentrations mediates c-Ski expression potentially through the ERK/CREB pathway rather than through the classic TGF-β1/Smad pathway.

Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.

PubMed

Marcelain, Katherine; Armisen, Ricardo; Aguirre, Adam; Ueki, Nobuhide; Toro, Jessica; Colmenares, Clemencia; Hayman, Michael J

2012-01-01

Ski is a transcriptional regulator that has been considered an oncoprotein given its ability to induce oncogenic transformation in avian model systems. However, studies in mouse and in some human tumor cells have also indicated a tumor suppressor activity for this protein. We found that Ski-/- mouse embryo fibroblasts exhibit high levels of genome instability, namely aneuploidy, consistent with a tumor suppressor function for Ski. Time-lapse microscopy revealed lagging chromosomes and chromatin/chromosome bridges as the major cause of micronuclei (MN) formation and the subsequent aneuploidy. Although these cells arrested in mitosis after treatment with spindle disrupting drugs and exhibited a delayed metaphase/anaphase transition, spindle assembly checkpoint (SAC) was not sufficient to prevent chromosome missegregation, consistent with a weakened SAC. Our in vivo analysis also showed dynamic metaphase plate rearrangements with switches in polarity in cells arrested in metaphase. Importantly, after ectopic expression of Ski the cells that displayed this metaphase arrest died directly during metaphase or after aberrant cell division, relating SAC activation and mitotic cell death. This increased susceptibility to undergo mitosis-associated cell death reduced the number of MN-containing cells. The presented data support a new role for Ski in the mitotic process and in maintenance of genetic stability, providing insights into the mechanism of tumor suppression mediated by this protein. Copyright © 2011 Wiley Periodicals, Inc.

High-grade renal injuries are often isolated in sports-related trauma.

PubMed

Patel, Darshan P; Redshaw, Jeffrey D; Breyer, Benjamin N; Smith, Thomas G; Erickson, Bradley A; Majercik, Sarah D; Gaither, Thomas W; Craig, James R; Gardner, Scott; Presson, Angela P; Zhang, Chong; Hotaling, James M; Brant, William O; Myers, Jeremy B

2015-07-01

Most high-grade renal injuries (American Association for Surgery of Trauma (AAST) grades III-V) result from motor vehicle collisions associated with numerous concomitant injuries. Sports-related blunt renal injury tends to have a different mechanism, a solitary blow to the flank. We hypothesized that high-grade renal injury is often isolated in sports-related renal trauma. We identified patients with AAST grades III-V blunt renal injuries from four level 1 trauma centres across the United States between 1/2005 and 1/2014. Patients were divided into "Sport" or "Non-sport" related groups. Outcomes included rates of hypotension (systolic blood pressure <90mm Hg), tachycardia (>110bpm), concomitant abdominal injury, and procedural/surgical intervention between sports and non-sports related injury. 320 patients met study criteria. 18% (59) were sports-related injuries with the most common mechanisms being skiing, snowboarding and contact sports (25%, 25%, and 24%, respectively). Median age was 24 years for sports and 30 years for non-sports related renal injuries (p=0.049). Males were more commonly involved in sports related injuries (85% vs. 72%, p=0.011). Median injury severity score was lower for sports related injuries (10 vs. 27, p<0.001). There was no difference in renal abbreviated injury scale scores. Sports related trauma was more likely to be isolated without other significant injury (69% vs. 39% (p<0.001)). Haemodynamic instability was present in 40% and 51% of sports and non-sports renal injuries (p=0.30). Sports injuries had lower transfusion (7% vs. 47%, p<0.001) and lower mortality rates (0% vs. 6%, p=0.004). There was no difference in renal-specific procedural interventions between the two groups (17% sports vs. 18% non-sports, p=0.95). High-grade sports-related blunt renal trauma is more likely to occur in isolation without other abdominal or thoracic injuries and clinicians must have a high suspicion of renal injury with significant blows to the flank during sports activities. Copyright © 2015 Elsevier Ltd. All rights reserved.

High-grade renal injuries are often isolated in sports-related trauma

PubMed Central

Patel, Darshan P.; Redshaw, Jeffrey D.; Breyer, Benjamin N.; Smith, Thomas G.; Erickson, Bradley A.; Majercik, Sarah D.; Gaither, Thomas W.; Craig, James R.; Gardner, Scott; Presson, Angela P.; Zhang, Chong; Hotaling, James M.; Brant, William O.; Myers, Jeremy B.

2016-01-01

Introduction Most high-grade renal injuries (American Association for Surgery of Trauma (AAST) grades III–V) result from motor vehicle collisions associated with numerous concomitant injuries. Sports-related blunt renal injury tends to have a different mechanism, a solitary blow to the flank. We hypothesized that high-grade renal injury is often isolated in sports-related renal trauma. Material and methods We identified patients with AAST grades III–V blunt renal injuries from four level 1 trauma centres across the United States between 1/2005 and 1/2014. Patients were divided into “Sport” or “Non-sport” related groups. Outcomes included rates of hypotension (systolic blood pressure <90 mm Hg), tachycardia (>110 bpm), concomitant abdominal injury, and procedural/surgical intervention between sports and non-sports related injury. Results 320 patients met study criteria. 18% (59) were sports-related injuries with the most common mechanisms being skiing, snowboarding and contact sports (25%, 25%, and 24%, respectively). Median age was 24 years for sports and 30 years for non-sports related renal injuries (p = 0.049). Males were more commonly involved in sports related injuries (85% vs. 72%, p = 0.011). Median injury severity score was lower for sports related injuries (10 vs. 27, p < 0.001). There was no difference in renal abbreviated injury scale scores. Sports related trauma was more likely to be isolated without other significant injury (69% vs. 39% (p < 0.001)). Haemodynamic instability was present in 40% and 51% of sports and non-sports renal injuries (p = 0.30). Sports injuries had lower transfusion (7% vs. 47%, p < 0.001) and lower mortality rates (0% vs. 6%, p = 0.004). There was no difference in renal-specific procedural interventions between the two groups (17% sports vs. 18% non-sports, p = 0.95). Conclusions High-grade sports-related blunt renal trauma is more likely to occur in isolation without other abdominal or thoracic injuries and clinicians must have a high suspicion of renal injury with significant blows to the flank during sports activities. PMID:25769197

Helmets and Mouth Guards: The Role of Personal Equipment in Preventing Sport-Related Concussions

PubMed Central

Daneshvar, Daniel H.; Baugh, Christine M.; Nowinski, Christopher J.; McKee, Ann C.; Stern, Robert A.; Cantu, Robert C.

2010-01-01

Every year, millions of athletes in the United States experience concussions. With athletes at all levels of play getting bigger, faster, and stronger, it has been suggested that newer technologies may provide an opportunity to reduce the risk and severity of these all too frequent injuries. Although helmets have been shown to decrease the rate of catastrophic head injuries, and mouth guards have decreased the risk of dental and oral injuries, the protective effect of helmets and mouth guards on concussions has not been conclusively demonstrated. In this review, the current literature pertaining to the effect that equipment has on concussions is evaluated. Understanding the role that this equipment plays in preventing concussions is complicated by many factors, such as selection bias in non-randomized studies, variations in playing style, and risk compensation in sports with mandatory protective equipment. At this point, there is little evidence supporting the use of specific helmets or mouth guards to prevent concussions outside of specific sports such as cycling, skiing, and snowboarding. Improving coach and player education about proper concussion management, encouraging neck strengthening exercises, and minimizing high-risk impacts may provide a more fruitful avenue to reduce concussions in sports. PMID:21074089

33 CFR 165.T11-0551 - Safety Zone; America's Cup Sailing Events.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Sailing Events. 165.T11-0551 Section 165.T11-0551 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... § 165.T11-0551 Safety Zone; America's Cup Sailing Events. (a) Definitions—(1) America's Cup Racing... 34th America's Cup sailing events. (2) Patrol Commander. As used in this section, “Patrol Commander” or...

33 CFR 165.805 - Security Zones; Calcasieu River and Ship Channel, Louisiana.

Code of Federal Regulations, 2010 CFR

2010-07-01

... authorized by the Captain of the Port. Coast Guard patrol assets will be on scene with flashing blue lights... regulations, contact Marine Safety Unit Lake Charles at (337) 491-7800 or the on scene patrol vessel. (5) All... municipal law enforcement agencies. (c) Informational broadcasts: The Captain of the Port, Port Arthur will...

U.S. border patrol potential applications of internetted unattended ground sensors

NASA Astrophysics Data System (ADS)

Eaton, Wilbur W., Jr.; Schatzmann, Larry A.

1997-07-01

The U.S. Border Patrol monitors the traffic on the Mexican/U.S. Border, the Canadian/U.S. Border and along some coastal areas. Measures have been taken to reduce or eliminate illegal immigration and smuggling. An automated border surveillance sub-system based on the DARPA Internetted Unattended Ground Sensors Program is discussed.

Education Requirements of Command Positions in the U.S. Border Patrol

DTIC Science & Technology

2015-06-12

BIBLIOGRAPHY ............................................................................................................110 viii ACRONYMS BPA ...and ports of entry.3 As the USBP changed, so did the requirements of its positions. The duties of the Border Patrol Agent ( BPA ) position today are...more complex, challenging, and demanding than they were twenty years ago.4 In just over a decade, most BPA positions increased in grade, including

77 FR 28538 - Special Local Regulations; Annual Bayview Mackinac Race

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

... contacted on Channel 16 (156.8 MHZ) by the call sign ``Coast Guard Patrol Commander.'' Vessels allowed... PATCOM to transit the area of the event by hailing call sign ``Coast Guard Patrol Commander'' on Channel... seven hours on a single day in July. Also, the regulated area will be a relatively small and only in...

20 CFR 1002.62 - Does USERRA cover a member of the Commissioned Corps of the National Oceanic and Atmospheric...

Code of Federal Regulations, 2014 CFR

2014-04-01

... Commissioned Corps of the National Oceanic and Atmospheric Administration, the Civil Air Patrol, or the Coast... and Atmospheric Administration, the Civil Air Patrol, or the Coast Guard Auxiliary? No. Although the Commissioned Corps of the National Oceanic and Atmospheric Administration (NOAA) is a “uniformed service” for...

20 CFR 1002.62 - Does USERRA cover a member of the Commissioned Corps of the National Oceanic and Atmospheric...

Code of Federal Regulations, 2010 CFR

2010-04-01

... Commissioned Corps of the National Oceanic and Atmospheric Administration, the Civil Air Patrol, or the Coast... and Atmospheric Administration, the Civil Air Patrol, or the Coast Guard Auxiliary? No. Although the Commissioned Corps of the National Oceanic and Atmospheric Administration (NOAA) is a “uniformed service” for...

20 CFR 1002.62 - Does USERRA cover a member of the Commissioned Corps of the National Oceanic and Atmospheric...

Code of Federal Regulations, 2011 CFR

2011-04-01

... Commissioned Corps of the National Oceanic and Atmospheric Administration, the Civil Air Patrol, or the Coast... and Atmospheric Administration, the Civil Air Patrol, or the Coast Guard Auxiliary? No. Although the Commissioned Corps of the National Oceanic and Atmospheric Administration (NOAA) is a “uniformed service” for...

20 CFR 1002.62 - Does USERRA cover a member of the Commissioned Corps of the National Oceanic and Atmospheric...

Code of Federal Regulations, 2013 CFR

2013-04-01

... Commissioned Corps of the National Oceanic and Atmospheric Administration, the Civil Air Patrol, or the Coast... and Atmospheric Administration, the Civil Air Patrol, or the Coast Guard Auxiliary? No. Although the Commissioned Corps of the National Oceanic and Atmospheric Administration (NOAA) is a “uniformed service” for...

20 CFR 1002.62 - Does USERRA cover a member of the Commissioned Corps of the National Oceanic and Atmospheric...

Code of Federal Regulations, 2012 CFR

2012-04-01

... Commissioned Corps of the National Oceanic and Atmospheric Administration, the Civil Air Patrol, or the Coast... and Atmospheric Administration, the Civil Air Patrol, or the Coast Guard Auxiliary? No. Although the Commissioned Corps of the National Oceanic and Atmospheric Administration (NOAA) is a “uniformed service” for...

Environmental Activities of the U.S. Coast Guard

DTIC Science & Technology

2009-05-07

Antarctic , and provides supplies to remote stations. The USCG also participates in the International Ice Patrol, which monitors iceberg danger in...the northwest Atlantic, particularly in the area of the Grand Banks of Newfoundland. The iceberg season is usually from February to July, but the Ice...Patrol is logistically flexible and can commence operations when iceberg conditions dictate

Commander, U.S. Pacific Fleet

Science.gov Websites

Us SAN DIEGO (May 22, 2018) Sailors assigned to Coastal Riverine Squadron (CRS) 3 operate a Mark VI patrol boat during a final evaluation problem conducted by Coastal Riverine Group (CRG) 1's training and ./Released) Sailors assigned to Coastal Riverine Squadron 3 operate a Mark VI patrol boat in waters off San

Changes in water quality along the course of a river - Classic monitoring versus patrol monitoring

NASA Astrophysics Data System (ADS)

Absalon, Damian; Kryszczuk, Paweł; Rutkiewicz, Paweł

2017-11-01

Monitoring of water quality is a tool necessary to assess the condition of waterbodies in order to properly formulate water management plans. The paper presents the results of patrol monitoring of a 40-kilometre stretch of the Oder between Racibórz and Koźle. It has been established that patrol monitoring is a good tool for verifying the distribution of points of classic stationary monitoring, particularly in areas subject to varied human impact, where tributaries of the main river are very diversified as regards hydrochemistry. For this reason the results of operational monitoring carried out once every few years may not be reliable and the presented condition of the monitored waterbodies may be far from reality.

CryoEM structure of yeast cytoplasmic exosome complex.

PubMed

Liu, Jun-Jie; Niu, Chu-Ya; Wu, Yao; Tan, Dan; Wang, Yang; Ye, Ming-Da; Liu, Yang; Zhao, Wenwei; Zhou, Ke; Liu, Quan-Sheng; Dai, Junbiao; Yang, Xuerui; Dong, Meng-Qiu; Huang, Niu; Wang, Hong-Wei

2016-07-01

The eukaryotic multi-subunit RNA exosome complex plays crucial roles in 3'-to-5' RNA processing and decay. Rrp6 and Ski7 are the major cofactors for the nuclear and cytoplasmic exosomes, respectively. In the cytoplasm, Ski7 helps the exosome to target mRNAs for degradation and turnover via a through-core pathway. However, the interaction between Ski7 and the exosome complex has remained unclear. The transaction of RNA substrates within the exosome is also elusive. In this work, we used single-particle cryo-electron microscopy to solve the structures of the Ski7-exosome complex in RNA-free and RNA-bound forms at resolutions of 4.2 Å and 5.8 Å, respectively. These structures reveal that the N-terminal domain of Ski7 adopts a structural arrangement and interacts with the exosome in a similar fashion to the C-terminal domain of nuclear Rrp6. Further structural analysis of exosomes with RNA substrates harboring 3' overhangs of different length suggests a switch mechanism of RNA-induced exosome activation in the through-core pathway of RNA processing.

Smad3 allostery links TGF-β receptor kinase activation to transcriptional control

PubMed Central

Qin, Bin Y.; Lam, Suvana S.; Correia, John J.; Lin, Kai

2002-01-01

Smad3 transduces the signals of TGF-βs, coupling transmembrane receptor kinase activation to transcriptional control. The membrane-associated molecule SARA (Smad Anchor for Receptor Activation) recruits Smad3 for phosphorylation by the receptor kinase. Upon phosphorylation, Smad3 dissociates from SARA and enters the nucleus, in which its transcriptional activity can be repressed by Ski. Here, we show that SARA and Ski recognize specifically the monomeric and trimeric forms of Smad3, respectively. Thus, trimerization of Smad3, induced by phosphorylation, simultaneously activates the TGF-β signal by driving Smad3 dissociation from SARA and sets up the negative feedback mechanism by Ski. Structural models of the Smad3/SARA/receptor kinase complex and Smad3/Ski complex provide insights into the molecular basis of regulation. PMID:12154125

Analysis and Comparison of the Temperature and Snowfall Conditions for the Winters of 2014/15 and 2015/16 at Three Ski Resorts in British Columbia, Canada

NASA Astrophysics Data System (ADS)

Pidwirny, M. J.; Pedersen, S.

2016-12-01

Most ski resorts located close to the west coast of Canada experienced extremely poor weather conditions during the winter of 2014/15. During this year, a persistent area of high pressure created "the Blob" in the North Pacific Ocean, which influenced weather patterns on the west coast of North America producing very mild temperatures inland. Further, for many ski resorts winter precipitation that normally arrives in the form of snow, instead fell as rain on many occasions. In Western Canada, ski resorts saw an 18% decrease in skier visits in 2014/15 relative to the average of the previous 8 years. NOAA forecasts for the winter of 2015/16 suggested another mild winter because of a strong El Nino event. Despite this forecast, ski resorts in Western Canada experienced a very good ski season. This research examines the climate characteristics of the winters of 2014/15 and 2015/16 in detail for three ski resorts in British Columbia, Canada: Whistler-Blackcomb, Cypress Mountain, and Big White. The climatic characteristics of these 2 years were also compared to the winter of 2012/13, the most recent banner ski year in the last decade. Data for this study came from Snow-Forecast.com, a web-based company that creates tailor-made weather forecasts for ski resorts around the world using climate model output from NOAA. From Snow-Forecast.com, we mined archived hindcast data that was available at the daily level to analyze and compare mean air temperature and snowfall patterns from November 1 to March 31. Daily temperature data was plotted in a line graph for each year. To better clarify trends, we also graphed an 11-year running mean for the temperature data. Snowfall data was plotted in a cumulative line graph. The winter of 2014/15 was on average warmer by 3.9°C for Cypress, 5.4°C for Whistler, and 4.4°C for Big White than the winter of 2012/13. The winter of 2015/16 was on average 2.5°C, 3.6°C, and 3.6°C warmer than the winter of 2012/13, respectively. Snowfall accumulations decreased by about 79% for Cypress, 57% for Whistler, and 9% for Big White in 2014/15 when compared to 2012/13. In contrast, the winter of 2015/16 saw snowfall increases of 10% for Cypress, 35% for Whistler, and 97% for Big White relative to 2012/13. Together, the colder temperatures and higher snowfall produced better than expected ski conditions in 2015/16.

36 CFR 3.12 - May I use a vessel to tow a person for water skiing or other similar activities?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false May I use a vessel to tow a person for water skiing or other similar activities? 3.12 Section 3.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.12 May I use a vessel to tow a person for water skiing o...

36 CFR 3.12 - May I use a vessel to tow a person for water skiing or other similar activities?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false May I use a vessel to tow a person for water skiing or other similar activities? 3.12 Section 3.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.12 May I use a vessel to tow a person for water skiing o...

Spatial Analysis of the Effects of the Anomalous Winter of 2014/15 on 157 Ski Resorts Located in Western North America

NASA Astrophysics Data System (ADS)

Bahbahani, K. M.; Pidwirny, M. J.

2017-12-01

The winter of 2014/2015 was one of the warmest in recent history for many locations in western North America. The cause of this climate irregularity was the development of extremely warm ocean surface waters (The Blob) over much of the eastern North Pacific Ocean. During this winter season, many ski resorts in western Canada and the United States either did not open or were forced to close their ski season early. Here, we examine climate data from 157 ski resorts to develop a picture of where the effected locations were in western North America. Using the climate database software ClimateBC and ClimateNA, high quality downscaled historical data was generated for the winter season (December, January, and February) for the variables mean temperature, snowfall, and rainfall. Values for winter of 2014/15 were statistically compared to the 30-year normal period from 1981-2010. Z-scores were calculated for 2014/15 relative to the selected 30-year normal period. These Z-score values were then mapped using ArcGIS. From the mean winter temperature map, it is apparent that abnormally warm temperatures influenced many ski resorts in California, Nevada, western Oregon, Washington, Arizona, Utah, southern Idaho, and parts of southern British Columbia. The winter snowfall map shows anomalous below normal conditions only at two resorts in south-central British Columbia and a single above normal situation at one site in central Colorado. The winter rainfall map displays that many ski resorts in New Mexico, Arizona, southern Utah, Colorado, Wyoming, Montana, Idaho, western Washington, and southwestern British Columbia experienced exceptional above normal winter season rainfalls. It is highly likely that the next Blob will be forecasted many months in advance of its occurrence. The results of this study have identified which ski resorts could be climatically influenced by such an event. This information may help reduce potential financial losses to ski resorts and their associated stakeholders when the next Blob shows up.

A local scale assessment of the climate change sensitivity of snow in Pyrenean ski resorts

NASA Astrophysics Data System (ADS)

Pesado, Cristina; Pons, Marc; Vilella, Marc; López-Moreno, Juan Ignacio

2016-04-01

The Pyrenees host one of the largest ski area in Europe after the Alps that encompasses the mountain area of the south of France, the north of Spain and the small country of Andorra. In this region, winter tourism is one of the main source of income and driving force of local development on these mountain communities. However, this activity was identified as one of the most vulnerable to a future climate change due to the projected decrease of natural snow and snowmaking capacity. However, within the same ski resorts different areas showed to have a very different vulnerability within the same resort based on the geographic features of the area and the technical management of the slopes. Different areas inside a same ski resort could have very different vulnerability to future climate change based on aspect, steepness or elevation. Furthermore, the technical management of ski resorts, such as snowmaking and grooming were identified to have a significant impact on the response of the snowpack in a warmer climate. In this line, two different ski resorts were deeply analyzed taken into account both local geographical features as well as the effect of the technical management of the runs. Principal Component Analysis was used to classify the main areas of the resort based on the geographic features (elevation, aspect and steepness) and identify the main representative areas with different local features. Snow energy and mass balance was simulated in the different representative areas using the Cold Regions Hydrological Model (CRHM) assuming different magnitudes of climate warming (increases of 2°C and 4°C in the mean winter temperature) both in natural conditions and assuming technical management of the slopes. Theses first results showed the different sensitivity and vulnerability to climate changes based on the local geography of the resort and the management of the ski runs, showing the importance to include these variables when analyzing the local vulnerability of a ski resort and the potential adaptation measures in each particular case.

Spatially explicit modeling of conflict zones between wildlife and snow sports: prioritizing areas for winter refuges.

PubMed

Braunisch, Veronika; Patthey, Patrick; Arlettaz, Raphaël

2011-04-01

Outdoor winter recreation exerts an increasing pressure upon mountain ecosystems, with unpredictable, free-ranging activities (e.g., ski mountaineering, snowboarding, and snowshoeing) representing a major source of stress for wildlife. Mitigating anthropogenic disturbance requires the spatially explicit prediction of the interference between the activities of humans and wildlife. We applied spatial modeling to localize conflict zones between wintering Black Grouse (Tetrao tetrix), a declining species of Alpine timberline ecosystems, and two free-ranging winter sports (off-piste skiing [including snow-boarding] and snowshoeing). Track data (snow-sports and birds' traces) obtained from aerial photographs taken over a 585-km transect running along the timberline, implemented within a maximum entropy model, were used to predict the occurrence of snow sports and Black Grouse as a function of landscape characteristics. By modeling Black Grouse presence in the theoretical absence of free-ranging activities and ski infrastructure, we first estimated the amount of habitat reduction caused by these two factors. The models were then extrapolated to the altitudinal range occupied by Black Grouse, while the spatial extent and intensity of potential conflict were assessed by calculating the probability of human-wildlife co-occurrence. The two snow-sports showed different distribution patterns. Skiers' occurrence was mainly determined by ski-lift presence and a smooth terrain, while snowshoers' occurrence was linked to hiking or skiing routes and moderate slopes. Wintering Black Grouse avoided ski lifts and areas frequented by free-ranging snow sports. According to the models, Black Grouse have faced a substantial reduction of suitable wintering habitat along the timberline transect: 12% due to ski infrastructure and another 16% when adding free-ranging activities. Extrapolating the models over the whole study area results in an overall habitat loss due to ski infrastructure of 10%, while there was a > 10% probability of human-wildlife encounters on 67% of the remaining area of suitable wintering habitat. Only 23% of the wintering habitat was thus free of anthropogenic disturbance. By identifying zones of potential conflict, while rating its relative intensity, our model provides a powerful tool to delineate and prioritize areas where wildlife winter refuges and visitor steering measures should be implemented.

Fluorine-labeled Dasatinib Nanoformulations as Targeted Molecular Imaging Probes in a PDGFB-driven Murine Glioblastoma Model12

PubMed Central

Benezra, Miriam; Hambardzumyan, Dolores; Penate-Medina, Oula; Veach, Darren R; Pillarsetty, Nagavarakishore; Smith-Jones, Peter; Phillips, Evan; Ozawa, Tatsuya; Zanzonico, Pat B; Longo, Valerie; Holland, Eric C; Larson, Steven M; Bradbury, Michelle S

2012-01-01

Dasatinib, a new-generation Src and platelet-derived growth factor receptor (PDGFR) inhibitor, is currently under evaluation in high-grade glioma clinical trials. To achieve optimum physicochemical and/or biologic properties, alternative drug delivery vehicles may be needed. We used a novel fluorinated dasatinib derivative (F-SKI249380), in combination with nanocarrier vehicles and metabolic imaging tools (microPET) to evaluate drug delivery and uptake in a platelet-derived growth factor B (PDGFB)-driven genetically engineered mouse model (GEMM) of high-grade glioma. We assessed dasatinib survival benefit on the basis of measured tumor volumes. Using brain tumor cells derived from PDGFB-driven gliomas, dose-dependent uptake and time-dependent inhibitory effects of F-SKI249380 on biologic activity were investigated and compared with the parent drug. PDGFR receptor status and tumor-specific targeting were non-invasively evaluated in vivo using 18F-SKI249380 and 18F-SKI249380-containing micellar and liposomal nanoformulations. A statistically significant survival benefit was found using dasatinib (95 mg/kg) versus saline vehicle (P < .001) in tumor volume-matched GEMM pairs. Competitive binding and treatment assays revealed comparable biologic properties for F-SKI249380 and the parent drug. In vivo, Significantly higher tumor uptake was observed for 18F-SKI249380-containing micelle formulations [4.9 percentage of the injected dose per gram tissue (%ID/g); P = .002] compared to control values (1.6%ID/g). Saturation studies using excess cold dasatinib showed marked reduction of tumor uptake values to levels in normal brain (1.5%ID/g), consistent with in vivo binding specificity. Using 18F-SKI249380-containing micelles as radiotracers to estimate therapeutic dosing requirements, we calculated intratumoral drug concentrations (24–60 nM) that were comparable to in vitro 50% inhibitory concentration values. 18F-SKI249380 is a PDGFR-selective tracer, which demonstrates improved delivery to PDGFB-driven high-grade gliomas and facilitates treatment planning when coupled with nanoformulations and quantitative PET imaging approaches. PMID:23308046

Melting in the Arctic: Preparing Now for Possibilities in the Future

DTIC Science & Technology

2016-04-04

shipping, exploration, research, tourism , military patrols, and unfortunately the potential for conflict. So far, climate change, diplomacy, and economic...presence such as shipping, exploration, research, tourism , military patrols, and unfortunately the potential for conflict. So far, climate change...Two, as well as the rest of the students, faculty, and staff, made this year a tremendous learning experience . ii

Preparing to Prevent: Conflict-Related Sexual Violence Mitigation Scenario-Based Training

DTIC Science & Technology

2014-11-26

role in the absence of adequate local authorities? 5) The patrol may have to provide first aid if the children are injured. Longer term assistance...Encounter: Rape Victim 26 5. Patrol Encounter: Report of Abducted Children 28 6. Sexual... Discrimination against Women, women and girls are frequently victims of rape, sexual molestation, culturally-sanctioned oppression, domestic violence

Predictors of patrol officer interest in cybercrime training and investigation in selected United States police departments.

PubMed

Holt, Thomas J; Bossler, Adam M

2012-09-01

Cybercrime has created substantial challenges for law enforcement, particularly at the local level. Most scholars and police administrators believe that patrol officers need to become more effective first responders to cybercrime calls. The evidence illustrates, however, that many patrol officers are neither adequately prepared nor strongly interested in taking an active role in addressing cybercrime at the local level. This study, therefore, examined the factors that predicted patrol officer interest in cybercrime training and investigations in two southeastern U.S. cities. The study specifically examined the relationship between demographics, cybercrime exposure, computer training, computer proficiency, Internet and cybercrime perceptions, and views on policing cybercrime with officer interest in cybercrime investigation training and conducting cybercrime investigations in the future. Officer views on policing cybercrime, particularly whether they valued cybercrime investigations and believed that cybercrime would dramatically change policing, along with their computer skills, were the strongest predictors of interest in cybercrime efforts. Officers who had received previous computer training were less interested in additional training and conducting investigations. These findings support the argument that more command and departmental meetings focusing on the value of investigating these types of crime need to be held in order to increase officer interest.

Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN.

PubMed

Mizuide, Masafumi; Hara, Takane; Furuya, Toshio; Takeda, Masafumi; Kusanagi, Kiyoshi; Inada, Yuri; Mori, Masatomo; Imamura, Takeshi; Miyazawa, Keiji; Miyazono, Kohei

2003-01-03

c-Ski and SnoN are transcriptional co-repressors that inhibit transforming growth factor-beta signaling through interaction with Smad proteins. Among receptor-regulated Smads, c-Ski and SnoN bind more strongly to Smad2 and Smad3 than to Smad1. Here, we show that c-Ski and SnoN bind to the "SE" sequence in the C-terminal MH2 domain of Smad3, which is exposed on the N-terminal upper side of the toroidal structure of the MH2 oligomer. The "QPSMT" sequence, located in the vicinity of SE, supports the interaction with c-Ski and SnoN. Sequences similar to SE and QPSMT are found in Smad2, but not in Smad1. The N-terminal MH1 domain and linker region of Smad3 protrude from the N-terminal upper side of the MH2 oligomer toroid. Smurf2 induces ubiquitin-dependent degradation of SnoN, since it appears to be located close to SnoN through binding to the linker region of Smad2. In contrast, transcription factors Mixer and FoxH3 (FAST1) bind to the bottom side of the Smad3 MH2 toroid; therefore, c-Ski does not affect the interaction of Smads with these transcription factors. Our findings thus demonstrate the stoichiometry of how multiple molecules can associate with the Smad oligomers and how the Smad-interacting proteins functionally interact with each other.

Technical snow production in skiing areas: conditions, practice, monitoring and modelling. A case study in Mayrhofen/Austria

NASA Astrophysics Data System (ADS)

Strasser, Ulrich; Hanzer, Florian; Marke, Thomas; Rothleitner, Michael

2017-04-01

The production of technical snow today is a self-evident feature of modern alpine skiing resort management. Millions of Euros are invested every year for the technical infrastructure and its operation to produce a homogeneous and continuing snow cover on the skiing slopes for the winter season in almost every larger destination in the Alps. In Austria, skiing tourism is a significant factor of the national economic structure. We present the framing conditions of technical snow production in the mid-size skiing resort of Mayrhofen (Zillertal Alps/Austria, 136 km slopes, elevation range 630 - 2.500 m a.s.l.). Production conditions are defined by the availability of water, the planned date for the season opening, and the climatic conditions in the weeks before. By means of an adapted snow production strategy an attempt is made to ecologically and economically optimize the use of water and energy resources. Monitoring of the snow cover is supported by a network of low-cost sensors and mobile snow depth recordings. Finally, technical snow production is simulated with the spatially distributed, physically based hydroclimatological model AMUNDSEN. The model explicitly considers individual snow guns and distributes the produced snow along the slopes. The amount of simulated snow produced by each device is a function of its type, of actual wet-bulb temperature at the location, of ski area infrastructure (in terms of water supply and pumping capacity), and of snow demand.

SKI2 mediates degradation of RISC 5'-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis.

PubMed

Branscheid, Anja; Marchais, Antonin; Schott, Gregory; Lange, Heike; Gagliardi, Dominique; Andersen, Stig Uggerhøj; Voinnet, Olivier; Brodersen, Peter

2015-12-15

Small regulatory RNAs are fundamental in eukaryotic and prokaryotic gene regulation. In plants, an important element of post-transcriptional control is effected by 20-24 nt microRNAs (miRNAs) and short interfering RNAs (siRNAs) bound to the ARGONAUTE1 (AGO1) protein in an RNA induced silencing complex (RISC). AGO1 may cleave target mRNAs with small RNA complementarity, but the fate of the resulting cleavage fragments remains incompletely understood. Here, we show that SKI2, SKI3 and SKI8, subunits of a cytoplasmic cofactor of the RNA exosome, are required for degradation of RISC 5', but not 3'-cleavage fragments in Arabidopsis. In the absence of SKI2 activity, many miRNA targets produce siRNAs via the RNA-dependent RNA polymerase 6 (RDR6) pathway. These siRNAs are low-abundant, and map close to the cleavage site. In most cases, siRNAs were produced 5' to the cleavage site, but several examples of 3'-spreading were also identified. These observations suggest that siRNAs do not simply derive from RDR6 action on stable 5'-cleavage fragments and hence that SKI2 has a direct role in limiting secondary siRNA production in addition to its function in mediating degradation of 5'-cleavage fragments. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

The relative efficiency of Iranian's rural traffic police: a three-stage DEA model.

PubMed

Rahimi, Habibollah; Soori, Hamid; Nazari, Seyed Saeed Hashemi; Motevalian, Seyed Abbas; Azar, Adel; Momeni, Eskandar; Javartani, Mehdi

2017-10-13

Road traffic Injuries (RTIs) as a health problem imposes governments to implement different interventions. Target achievement in this issue required effective and efficient measures. Efficiency evaluation of traffic police as one of the responsible administrators is necessary for resource management. Therefore, this study conducted to measure Iran's rural traffic police efficiency. This was an ecological study. To obtain pure efficiency score, three-stage DEA model was conducted with seven inputs and three output variables. At the first stage, crude efficiency score was measured with BCC-O model. Next, to extract the effects of socioeconomic, demographic, traffic count and road infrastructure as the environmental variables and statistical noise, the Stochastic Frontier Analysis (SFA) model was applied and the output values were modified according to similar environment and statistical noise conditions. Then, the pure efficiency score was measured using modified outputs and BCC-O model. In total, the efficiency score of 198 police stations from 24 provinces of 31 provinces were measured. The annual means (standard deviation) of damage, injury and fatal accidents were 247.7 (258.4), 184.9 (176.9), and 28.7 (19.5), respectively. Input averages were 5.9 (3.0) patrol teams, 0.5% (0.2) manpower proportions, 7.5 (2.9) patrol cars, 0.5 (1.3) motorcycles, 77,279.1 (46,794.7) penalties, 90.9 (2.8) cultural and educational activity score, 0.7 (2.4) speed cameras. The SFA model showed non-significant differences between police station performances and the most differences attributed to the environmental and random error. One-way main road, by road, traffic count and the number of household owning motorcycle had significant positive relations with inefficiency score. The length of freeway/highway and literacy rate variables had negative relations, significantly. Pure efficiency score was with mean of 0.95 and SD of 0.09. Iran's traffic police has potential opportunity to reduce RTIs. Adjusting police performance with environmental conditions is necessary. Capability of DEA method in setting quantitative targets for every station induces motivation for managers to reduce RTIs. Repetition of this study is recommended, annually.

PROSNOW - Provision of a prediction system allowing for management and optimization of snow in Alpine ski resorts

NASA Astrophysics Data System (ADS)

Morin, Samuel; Ghislain, Dubois

2017-04-01

Snow on the ground is a critical resource for mountain regions to sustain river flow, to provide freshwater input to ecosystems and to support winter tourism, in particular in ski resorts. The level of activity, employment, turnover and profit of hundreds of ski resorts in the European Alps primarily depends on meteorological conditions, in particular natural snowfall but also increasingly conditions favourable for snowmaking (production of machine made snow, also referred to as technical snow). Ski resorts highly depend on appropriate conditions for snowmaking (mainly the availability of cold water, as well as sub-freezing temperature with sufficiently low humidity conditions). However, beyond the time scale of weather forecasts (a few days), managers of ski resorts have to rely on various and scattered sources of information, hampering their ability to cope with highly variable meteorological conditions. Improved anticipation capabilities at all time scales, spanning from "weather forecast" (up to 5 days typically) to "climate prediction" at the seasonal scale (up to several months) holds significant potential to increase the resilience of socio-economic stakeholders and supports their real-time adaptation potential. To address this issue, the recently funded (2017-2020) H2020 PROSNOW project will build a demonstrator of a meteorological and climate prediction and snow management system from one week to several months ahead, specifically tailored to the needs of the ski industry. PROSNOW will apply state-of-the-art knowledge relevant to the predictability of atmospheric and snow conditions, and investigate and document the added value of such services. The project proposes an Alpine-wide system (including ski resorts located in France, Switzerland, Germany, Austria and Italy). It will join and link providers of weather forecasts and climate predictions at the seasonal scale, research institutions specializing in snowpack modelling, a relevant ensemble of at least 8 representative resorts in the Alps, technical bodies representing ski resorts managers, and private technology companies. These companies are already providing services for snow management such as snow depth monitoring, snowmaking operations monitoring and planning using latest technologies. The added value of the demonstrator will be assessed for the ski industry, but also for additional stakeholders including local and regional tourism authorities, hydropower managers, and natural hazard forecasters and planners. This presentation will introduce the main goals and concepts of the PROSNOW project, in order to foster interactions with the specialized scientific communities relevant to this challenge.

Comprehensive outreach, prevention education, and skin cancer screening for Utah ski resorts.

PubMed

Varedi, Amir; Secrest, Aaron M; Harding, Garrett; Maness, Lori; Branson, Donna; Smith, Kristi; Hull, Christopher M

2018-02-15

Outdoor recreation can lead to substantial sun exposure. Employees of outdoor recreation establishments with extended time outdoors have amplified cumulative exposure to ultraviolet (UV) radiation and an increased risk of skin cancer. The "Sun Safe on the Slopes" program was created by Huntsman Cancer Institute at the University of Utah and the Utah Cancer Action Network to address increased UV exposure and skin cancer risk with free skin cancer screenings, outreach, and prevention education to local ski resorts. Herein, we describe the processes and barriers to implementation of a ski resort skin screening and education program and our 5-year report of the experience and screening data. Nine free skin cancer screenings were held at Utah ski resorts between 2011 and 2016, resulting in the presumptive diagnosis of 38 skin cancers (9.6%) in 394 participants. Behavioral data collected from participants indicates suboptimal sun safety practices, including underuse of sunscreen and protective clothing. Ski resort employees who experience sun exposure during peak hours at high altitudes and UV reflection from the snow are at an increased risk of skin cancer. These data indicate a need for emphasis on sun safety education and screening and can serve as a model for future endeavors.

Negative regulation of BMP signaling by the ski oncoprotein.

PubMed

Luo, Kunxin

2003-01-01

The bone morphogenetic proteins (BMPs) play important roles in the regulation of multiple aspects of vertebrate development. BMPs signal through the cell surface receptors and downstream Smad molecules. Upon stimulation with BMP, Smad1, Smad5, and Smad8 are phosphorylated by the activated BMP receptors, form a complex with Smad4, and translocate into the nucleus, where they regulate the expression of BMP target genes. The activity of this signal pathway can be modulated both by extracellular factors that regulate the binding of BMPs to the receptor and by intracellular proteins that interact with the Smad proteins. We have shown that Ski is an important negative regulator of the Smad proteins. Ski can bind to the BMP-Smad protein complexes in response to BMP and repress their ability to activate BMP target genes through disruption of a functional Smad complex and through recruitment of transcriptional co-repressors. The antagonism of BMP signaling by Ski results in neural specification in Xenopus embryos and inhibition of osteoblast differentiation in mouse bone-marrow stromal progenitor cells. This ability to modulate BMP signaling by Ski may play an important role in the regulation of craniofacial, neuronal, and skeletal muscle development.

SnoN co-repressor binds and represses smad7 gene promoter.

PubMed

Briones-Orta, Marco A; Sosa-Garrocho, Marcela; Moreno-Alvarez, Paola; Fonseca-Sánchez, Miguel A; Macías-Silva, Marina

2006-03-17

SnoN and Ski oncoproteins are co-repressors for Smad proteins and repress TGF-beta-responsive gene expression. The smad7 gene is a TGF-beta target induced by Smad signaling, and its promoter contains the Smad-binding element (SBE) required for a positive regulation by the TGF-beta/Smad pathway. SnoN and Ski co-repressors also bind SBE but regulate negatively smad7 gene. Ski along with Smad4 binds and represses the smad7 promoter, whereas the repression mechanism by SnoN is not clear. Ski and SnoN overexpression inhibits smad7 reporter expression induced through TGF-beta signaling. Using chromatin immunoprecipitation assays, we found that SnoN binds smad7 promoter at the basal condition, whereas after a short TGF-beta treatment for 15-30 min SnoN is downregulated and no longer bound smad7 promoter. Interestingly, after a prolonged TGF-beta treatment SnoN is upregulated and returns to its position on the smad7 promoter, functioning probably as a negative feedback control. Thus, SnoN also seems to regulate negatively the TGF-beta-responsive smad7 gene by binding and repressing its promoter in a similar way to Ski.

Sex-Specific Predictors of Intra-articular Injuries Observed During Anterior Cruciate Ligament Reconstruction.

PubMed

Kluczynski, Melissa A; Marzo, John M; Rauh, Michael A; Bernas, Geoffrey A; Bisson, Leslie J

2015-02-01

Male patients tend to have more meniscal and chondral injuries at the time of anterior cruciate ligament (ACL) reconstruction than females. No studies have examined sex-specific predictors of meniscal and chondral lesions in ACL-injured patients. To identify sex-specific predictors of meniscal and chondral lesions, as well as meniscal tear management, in patients undergoing ACL reconstruction. Cohort study; Level of evidence, 3. Data were collected prospectively from 689 patients (56.2% males) undergoing ACL reconstruction between 2005 and 2014. Predictors of meniscal tears, meniscal tear management, and chondral injuries were determined using multivariate logistic regression models stratified by sex. Predictors were age, body mass index (BMI; 25-29.99 and ≥30 vs ≤24.99 kg/m(2)), mechanism (contact vs noncontact) and type (high-impact sports [basketball, football, soccer, and skiing] and other sports vs not sports-related) of injury, interval from injury to surgery (≤6 vs >6 weeks), and instability episodes (vs none). Odds ratios and 95% CIs were reported. Males had more lateral (46% vs 27.8%; P < .0001) and medial (40.2% vs 31.5%; P = .01) meniscal tears, as well as more lateral (72.1% vs 27.9%; P < .0001) and medial (61.4% vs 38.6%; P = .01) meniscectomies than females. For males, age predicted chondral injuries and medial meniscectomy; BMI ≥30 kg/m(2) predicted medial meniscal tears; high-impact and other sports predicted medial meniscal tears, medial meniscectomies, and medial meniscal repairs; injuries ≤6 weeks from surgery predicted lateral meniscal repairs; and instability episodes predicted medial meniscal tears, medial tears left in situ, medial meniscectomies, and medial meniscal repairs. For females, age predicted chondral injuries, BMI ≥30 kg/m(2) predicted lateral meniscectomies and repairs, and instability episodes predicted medial meniscectomies. Sex differences were observed. For males, predictors included age, BMI, sports-related injuries, injuries ≤6 weeks from surgery, and instability episodes. For females, predictors included age, BMI, and instability episodes.

CHANGES IN HEART RATE VARIABILITY AND LUNG FUNCTION OBSERVED IN NC PATROL TROOPERS EXPOSED TO PM AND AIR TOXICS

EPA Science Inventory

Changes in Heart Rate Variability and Lung Function in NC Patrol Troopers exposed to PM and Air Toxics

Michael Riediker1, Wayne E Cascio1, Robert B Devlin2, Thomas Griggs1&4, Margaret Herbst1, Ronald W Williams3, Steve P McCorquodale4, Philip A Bromberg1
1) University o...

Environmental Activities of the U.S. Coast Guard

DTIC Science & Technology

2007-01-16

icebreakers in the Arctic and Antarctic , and provides supplies to remote stations. These icebreakers typically carry about 40 scientists from universities as...the International Ice Patrol, which monitors iceberg danger in the northwest Atlantic, particularly in the area of the Grand Banks of Newfoundland...The iceberg season is usually from February to July, but the Ice Patrol is logistically flexible and can commence operations when iceberg conditions

Environmental Activities of the U.S. Coast Guard

DTIC Science & Technology

2007-04-25

Guard operates three icebreakers in the Arctic and Antarctic , and provides supplies to remote stations. These icebreakers typically carry about 40...USCG also participates in the International Ice Patrol, which monitors iceberg danger in the northwest Atlantic, particularly in the area of the Grand...Banks of Newfoundland. The iceberg season is usually from February to July, but the Ice Patrol is logistically flexible and can commence operations

United States Coast Guard Fiscal Year 2009 Performance Report

DTIC Science & Technology

2010-02-01

flooding. The International Ice Patrol facilitates interna- tional commerce by broadcasting information on iceberg locations to vessels transiting...SEA also provided back-up capability for the U.S. Antarctic Deep Freeze resupply mission. • The United States Coast Guard International Ice Patrol...tracked over 1,200 icebergs which drifted into the transatlantic shipping lanes continuing its perfect record, 96 years, of preventing ship collisions

Tactical Plan Generation Software for Maritime Interdiction Using Conceptual Blending Theory

DTIC Science & Technology

2007-12-01

littoral states of Indonesia, Malaysia , and Singapore are so important that they received international support from fifty countries and seventeen maritime...Marine Electronic Highway (MEH) along the Malacca Strait, by Malaysia [12]. C. MARITIME INTERDICTION 1. Surveillance and Data Fusion In maritime...operations. 4 Examples of patrols include the coordinated naval patrols conducted by Malaysia , Indonesia, and Singapore (Operation MALSINDO), which were

Antipoaching standards in onshore hydrocarbon concessions drawn from a Central African case study.

PubMed

Vanthomme, Hadrien P A; Tobi, Elie; Todd, Angelique F; Korte, Lisa; Alonso, Alfonso

2017-06-01

Unsustainable hunting outside protected areas is threatening tropical biodiversity worldwide and requires conservationists to engage increasingly in antipoaching activities. Following the example of ecocertified logging companies, we argue that other extractive industries managing large concessions should engage in antipoaching activities as part of their environmental management plans. Onshore hydrocarbon concessions should also adopt antipoaching protocols as a standard because they represent a biodiversity threat comparable to logging. We examined the spatiotemporal patterns of small- and large-mammal poaching in an onshore oil concession in Gabon, Central Africa, with a Bayesian occupancy model based on signs of poaching collected from 2010 to 2015 on antipoaching patrols. Patrol locations were initially determined based on local intelligence and past patrol successes (adaptive management) and subsequently with a systematic sampling of the concession. We generated maps of poaching probability in the concession and determined the temporal trends of this threat over 5 years. The spatiotemporal patterns of large- and small-mammal poaching differed throughout the concession, and likely these groups will need different management strategies. By elucidating the relationship between site-specific sampling effort and detection probability, the Bayesian method allowed us to set goals for future antipoaching patrols. Our results indicate that a combination of systematic sampling and adaptive management data is necessary to infer spatiotemporal patterns with the statistical method we used. On the basis of our case study, we recommend hydrocarbon companies interested in implementing efficient antipoaching activities in their onshore concessions to lay the foundation of long-needed industry standards by: adequately measuring antipoaching effort; mixing adaptive management and balanced sampling; setting goals for antipoaching effort; pairing patrols with large-mammal monitoring; supporting antipoaching patrols across the landscape; restricting access to their concessions; performing random searches for bushmeat and mammal products at points of entry; controlling urban and agricultural expansion; supporting bushmeat alternatives; and supporting land-use planning. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Conservation Biology published by Wiley Periodicals, Inc. on behalf of Society for Conservation Biology.

Collecting Kinematic Data on a Ski Track with Optoelectronic Stereophotogrammetry: A Methodological Study Assessing the Feasibility of Bringing the Biomechanics Lab to the Field.

PubMed

Spörri, Jörg; Schiefermüller, Christian; Müller, Erich

2016-01-01

In the laboratory, optoelectronic stereophotogrammetry is one of the most commonly used motion capture systems; particularly, when position- or orientation-related analyses of human movements are intended. However, for many applied research questions, field experiments are indispensable, and it is not a priori clear whether optoelectronic stereophotogrammetric systems can be expected to perform similarly to in-lab experiments. This study aimed to assess the instrumental errors of kinematic data collected on a ski track using optoelectronic stereophotogrammetry, and to investigate the magnitudes of additional skiing-specific errors and soft tissue/suit artifacts. During a field experiment, the kinematic data of different static and dynamic tasks were captured by the use of 24 infrared-cameras. The distances between three passive markers attached to a rigid bar were stereophotogrammetrically reconstructed and, subsequently, were compared to the manufacturer-specified exact values. While at rest or skiing at low speed, the optoelectronic stereophotogrammetric system's accuracy and precision for determining inter-marker distances were found to be comparable to those known for in-lab experiments (< 1 mm). However, when measuring a skier's kinematics under "typical" skiing conditions (i.e., high speeds, inclined/angulated postures and moderate snow spraying), additional errors were found to occur for distances between equipment-fixed markers (total measurement errors: 2.3 ± 2.2 mm). Moreover, for distances between skin-fixed markers, such as the anterior hip markers, additional artifacts were observed (total measurement errors: 8.3 ± 7.1 mm). In summary, these values can be considered sufficient for the detection of meaningful position- or orientation-related differences in alpine skiing. However, it must be emphasized that the use of optoelectronic stereophotogrammetry on a ski track is seriously constrained by limited practical usability, small-sized capture volumes and the occurrence of extensive snow spraying (which results in marker obscuration). The latter limitation possibly might be overcome by the use of more sophisticated cluster-based marker sets.

78 FR 53500 - Petition for Exemption From the Federal Motor Vehicle Theft Prevention Standard; Chrysler

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

...) transceiver and a microprocessor and it initiates the ignition process by communicating with the BCM through SKIS. The microprocessor-based SKIS hardware and software also use electronic messages to communicate...

A simulation model for forecasting downhill ski participation

Treesearch

Daniel J. Stynes; Daniel M. Spotts

1980-01-01

The purpose of this paper is to describe progress in the development of a general computer simulation model to forecast future levels of outdoor recreation participation. The model is applied and tested for downhill skiing in Michigan.

Adaptive downhill skiing in children with cerebral palsy: effect on gross motor function.

PubMed

Sterba, John A

2006-01-01

The study was designed to examine the effect of adaptive downhill skiing (ADS) on gross motor function in children with spastic cerebral palsy. One girl and four boys participated (mean age = eight years, five months). All were ambulatory. Participants' Gross Motor Function Measure (GMFM) classifications were: Level I (n = 2); Level II (n = 2); Level III (n = 1). ADS was conducted for a 10-week period at one ski resort. Each participant had the same ski instructor. GMFM was obtained every five weeks: beginning five weeks before ADS instruction and continuing to 10 weeks after ADS instruction. After 10 weeks of ADS GMFM-D, and GMFM-Total Score increased 5.4% (p = 0.022) and 3.2% (p = 0.035), respectively, and remained increased 10 weeks after ADS. ADS could be recommended by clinicians as a recreational activity for the gross motor rehabilitation of ambulatory children with spastic cerebral palsy.

Patrol car and agent tracking/suspect tagging and tracking

NASA Astrophysics Data System (ADS)

Wilkins, Steven C.

1997-01-01

Emerging technologies in the field of law enforcement are providing today's law enforcement personnel with the advantage of an innovative and faster means of providing safety and service to the public. The use of open such technology, the Automatic Vehicle Locator (AVL) tracking device, is fast becoming a commonplace and cost-effective solution for agencies to efficiently command and control their 'officer' assets. Through the use of AVL's global positioning satellite-based system, the response time of law enforcement is greatly enhanced by permitting a dispatcher to visually identify and assign the officer closest to the location of an accident or incident. The system is effective in reducing delays due to highway blockages, improving the level of protection to the motoring public, and promoting the flow of traffic on busy freeways. Likewise, an officer or agent in distress can be assured that a dispatcher will be constantly aware of his or her location in the field. In the 1990's the demands on law enforcement agencies have grown tremendously. this is due primarily to population increases, limited funding or resources, and increases in drug, property and violent crimes. Frequently, the automobile is used for escape after the commission of these crimes. This often results in high speed pursuits involving law enforcement agencies. In California, by statute, the California Highway Patrol is the central repository for data regarding all pursuits involving state and local law enforcement agencies. Statistics show that more than 10 percent of pursuits result in injuries to the violator and/or innocent bystanders. Most pursuits last less than 10 minutes, and the AVL system provides a tremendous advantage to law enforcement's ability to immediately deploy and direct units into pursuits for rapid closure of the incident. AVL systems not only reduce the risk of personal injury by minimizing public exposure to the unsafe incident, but also enhance officer safety during the high speed chase by pinpointing officer deployment. Officer safety is a primary concern for all law enforcement agencies, nationwide. In addition to the aforementioned benefits of AVL, this system ensures that dispatchers are continually aware of an officer's location. This is a critical feature for an officer who is unable to verbally provide his/her location over the radio due to adversarial or injury circumstances. AVL technology is neither rate nor risky, and it is fast becoming an accepted and cost-effective solution in law enforcement agencies, large and small. The challenge to industry is not merely the development of new AVL technology, but also the ease in which it will integrate with existing law enforcement systems.

Epidemiology of non-submersion injuries in aquatic sporting and recreational activities.

PubMed

Chalmers, David; Morrison, Luke

2003-01-01

Although the issues of drowning and near-drowning in aquatic sporting and recreational activities receive considerable attention in the epidemiological literature, there is not a recognised literature on non-submersion injuries occurring in these activities. This review draws together the epidemiological literature on non-submersion injuries and describes the incidence, nature and causes of these injuries, common risk factors, and strategies for prevention. Activities covered by the review include swimming, diving, boating, surf sports, fishing, water polo and water sliding. For most activities there is a dearth of good quality descriptive studies, with most involving cases-series designs and few providing estimates of incidence. Inconsistencies in inclusion criteria and the reporting of incidence rates makes comparisons within and between activities difficult. Incidence rates were identified for most activities and in general the incidence of injury was low, especially for more serious injury. However, some activities were associated with severely disabling injury, such as spinal cord injury (diving) and amputation (from propeller strikes in water skiing and swimming). Only three studies reporting the significance of postulated risk factors were identified. Lack of knowledge about the water being entered and alcohol consumption are significant risk factors in recreational diving; increased blood alcohol concentrations were reported to increase the risk of death in boating; and obesity and tandem riding were reported to increase the risk of injury on public water slides. Few evaluations of preventive measures were identified. Two studies reported reductions in the incidence of water slide injuries following the introduction of design changes and supervision, but neither had a non-intervention comparison group. Improvements in swimming and diving skills were reported in three studies, but these were not designed to measure changes in the risk of injury.This review demonstrates that there is a need for well-designed epidemiological research on non-submersion injury in aquatic sporting and recreational activities. The first priority should be for studies designed to describe accurately the incidence, nature, severity and circumstances of these injuries, followed by research on the significance of postulated risk factors. Once this research has been undertaken, interventions targeted at reducing the incidence of injury in aquatic sporting and recreational activities can be designed and evaluated.

Take-off analysis of the Olympic ski jumping competition (HS-106m).

PubMed

Virmavirta, Mikko; Isolehto, Juha; Komi, Paavo; Schwameder, Hermann; Pigozzi, Fabio; Massazza, Giuseppe

2009-05-29

The take-off phase (approximately 6m) of the jumps of all athletes participating in the individual HS-106m hill ski jumping competition at the Torino Olympics was filmed with two high-speed cameras. The high altitude of the Pragelato ski jumping venue (1600m) and slight tail wind in the final jumping round were expected to affect the results of this competition. The most significant correlation with the length of the jump was found in the in-run velocity (r=0.628, p<0.001, n=50). This was a surprise in Olympic level ski jumping, and suggests that good jumpers simply had smaller friction between their skis and the in-run tracks and/or the aerodynamic quality of their in-run position was better. Angular velocity of the hip joint of the best jumpers was also correlated with jumping distance (r=0.651, p<0.05, n=10). The best jumpers in this competition exhibited very different take-off techniques, but still they jumped approximately the same distance. This certainly improves the interests in ski jumping among athletes and spectators. The comparison between the take-off techniques of the best jumpers showed that even though the more marked upper body movement creates higher air resistance, it does not necessarily result in shorter jumping distance if the exposure time to high air resistance is not too long. A comparison between the first and second round jumps of the same jumpers showed that the final results in this competition were at least partly affected by the wind conditions.

Protective Effect of Triptolide against Glomerular Mesangial Cell Proliferation and Glomerular Fibrosis in Rats Involves the TGF-β1/Smad Signaling Pathway

PubMed Central

Cao, Yingjie; Huang, Xinzhong; Fan, Yaping; Chen, Xiaolan

2015-01-01

Triptolide as a main active ingredient of Tripterygium wilfordii is known to be exerting anti-inflammatory, marked immunosuppressive, and podocyte-protective effects. In this study, we investigated the protective effect of triptolide in kidney disease. Rat glomerular mesangial cells were randomly divided into three groups: (1) control group, (2) TGF-β1 (10 μg/mL) group, and (3) triptolide group (triptolide 10 μg/L + TGF-β1 10 μg/L). Sixty male Sprague-Dawley rats were randomly divided into three groups: (1) control group, (2) chronic serum sickness glomerulonephritis model group, and (3) triptolide (0.2 mg/kg·d) group. Reverse transcription PCR was used to assess Ski and Smad3 mRNA expression in the mesangial cells and renal tissues. Western blotting was used to determine Ski and Smad3 protein expressions. Laser confocal fluorescence microscopy was used to observe the subcellular localization of Smad3 and Ski proteins in the mesangial cells. Triptolide inhibited the TGF-β1-induced proliferation of mesangial cells. It significantly upregulated Ski protein expression and downregulated Smad3 mRNA and protein expressions in a time-dependent manner. Laser confocal fluorescence microscopy detected high Smad3 fluorescence intensity in the cytoplasm and low Smad3 and high Ski fluorescence intensity in the nucleus. By upregulating Ski protein expression triptolide decreased the extent of fibrosis by affecting the TGF-β1/Smad3 signaling pathway. PMID:26451157

Sphingosine kinase inhibitor suppresses IL-18-induced interferon-gamma production through inhibition of p38 MAPK activation in human NK cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheon, Soyoung; Song, Seok Bean; Jung, Minkyung

2008-09-12

Natural killer (NK) cells play an important role in the innate immune response. Interleukin-18 (IL-18) is a well-known interferon-gamma (IFN-{gamma} inducing factor, which stimulates immune response in NK and T cells. Sphingosine kinase (SPHK) catalyzes the formation of sphingosine 1-phosphate (S1P), which acts as a second messenger to function as an anti-apoptotic factor and proliferation stimulator of immune cells. In this study, to elucidate whether SPHK is involved in IL-18-induced IFN-{gamma} production, we measured IL-18-induced IFN-{gamma} production after pre-treatment with SPHK inhibitor (SKI) in NK-92MI cells. We found that IL-18-induced IFN-{gamma} expression was blocked by SKI pre-treatment in both mRNAmore » and protein levels. In addition, the increased IFN-{gamma} production by stimulation with IL-18 is mediated through both SPHK and p38 MAPK. To determine the upstream signals of SKI and p38 MAPK in IL-18-induced IFN-{gamma} production, phosphorylation levels of p38 MAPK was measured after SKI pre-treatment. As a result, inhibition of SPHK by SKI blocked phosphorylation of p38 MAPK, showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation. Inhibition of SPHK by SKI also inhibited IL-18-induced IFN-{gamma} production in human primary NK cells. In conclusion, SPHK activation is an essential factor for IL-18-induced IFN-{gamma} production via p38 MAPK.« less

76 FR 62785 - Nordica USA, Provisional Acceptance of a Settlement Agreement and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... (``Skis''). The binding plates on the skis could crack or break causing the skier to lose control or fall.... This knowledge required Nordica to immediately inform the Commission of the defect and risk associated...

ENERGY MANAGEMENT INNOVATION IN THE US SKI INDUSTRY

EPA Science Inventory

Ski areas represent a unique opportunity to develop innovative energy management practices in an industrial setting. Through a unique synergy of onsite generation, preferably by renewable sources and innovative technologies, and the energy storage potential of exis...

Economic Impacts of Climate Change on Winter Tourism: Challenges for Ski Area Operators

NASA Astrophysics Data System (ADS)

Damm, A.; Köberl, J.; Prettenthaler, F.; Töglhofer, C.

2012-04-01

Increasing temperatures and snow scarce winter seasons pose a big challenge for the winter tourism industry. Changing natural snow reliability influences tourism demand and ski area operators are faced with an enhanced need of technical snow production. The goal of the present research work is to analyze the economic effects of technical snow production under future climate conditions. Snowmaking as an adaptation strategy to climate change impacts on the ski tourism industry is already taken into consideration in several studies from a scientific perspective concerning snowmaking potentials under future climate conditions and the impacts on ski season length (e.g. Scott et al. 2003; Scott & McBoyle 2007; Hennessy et al. 2008; Steiger 2010). A few studies considered economic aspects of technical snowmaking (e.g. Teich et al. 2007; Gonseth 2008). However, a detailed analysis of the costs and benefits of snowmaking under future climate and snow conditions based on sophisticated climate and snow models has not been carried out yet. The present study addresses the gap of knowledge concerning the economic profitability of prospective snowmaking requirements under future climate scenarios. We carry out a detailed cost-revenue analysis of snowmaking under current and future climate conditions for a case study site in Styria (Austria) using dynamic investment models. The starting point of all economic calculations is the daily demand for artificial snow that determines the requirements for additional snowmaking investments and additional operating costs. The demand for artificial snow is delivered by the snow cover model AMUNDSEN (see Strasser et al. 2011) and is driven by four climate scenarios. Apart from future climate conditions the profitability of snowmaking depends on changes in costs and visitor numbers. The results of a ski tourism demand model analyzing daily visitor numbers and their dependencies of prevailing weather conditions enter the cost-revenue analysis of snowmaking and enable the determination of the immediate benefits in terms of additional revenues of ski ticket sales. Furthermore, we conduct an econometric analysis of how snowmaking investments changed ski ticket prices in previous years, as the positive effects of snowmaking on snow reliability could be offset in the longer term by the effects of higher prices for skiing, possibly resulting in lower demand.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This document is a summary brief of the Phase 1.0 and 1.1 reports previously published on this demonstration.

Forest research notes, Pacific Northwest Forest Experiment Station, No. 34, August 15, 1946.

Treesearch

William G. Morris; Thornton T. Munger; Harold A. Rapraeger; Leo A. Isaac

1946-01-01

With the recent use of airplane patrol to discover fires it has become important to review what is known about the visibility of smoke and to study any new theories or applications of present knowledge that are suggested, Airplane patrol is expensive on an hourly basis, The time available for the observer to see a smoke before he has passed too far beyond it is short....

Sochi, Russia Winter Olympic Sites Mountain Cluster

NASA Image and Video Library

2014-02-05

The 2014 Winter Olympic ski runs may be rated double black diamond, but theyre not quite as steep as they appear in this image acquired by NASA Terra spacecraft, of the skiing and snowboarding sites for the Sochi Winter Olympic Games.

Skier and Snowboarder Motivations and Knowledge Related to Voluntary Environmental Programs at an Alpine Ski Area

NASA Astrophysics Data System (ADS)

Little, Christopher M.; Needham, Mark D.

2011-11-01

Many alpine ski areas have recently adopted voluntary environmental programs (VEPs) such as using recycling, renewable energy, and biofuels to help reduce their environmental impacts. Studies have addressed the performance of these VEPs in mitigating environmental impacts of this industry, but little is known about visitor awareness and perceptions of these programs. This article addresses this knowledge gap by exploring skier and snowboarder knowledge of VEPs at a ski area and the influence of these programs on their motivations to visit this area currently and behavioral intentions to visit again in the future. Data were obtained from an onsite survey at the Mt. Bachelor ski area in Oregon, USA ( n = 429, 89.7% response rate). Few skiers and snowboarders were knowledgeable of VEPs at this area and fewer than 20% were motivated to visit on their current trip because of these programs. Other attributes such as scenery, snow conditions, and access were more important for influencing visitation. Up to 38% of skiers and snowboarders, however, intend to visit this ski area more often if it adopts and promotes more VEPs. Managers can use these results to inform communication and marketing of their environmental programs and performance to visitors. Additional implications for management and future research are discussed.

Skier and snowboarder motivations and knowledge related to voluntary environmental programs at an alpine ski area.

PubMed

Little, Christopher M; Needham, Mark D

2011-11-01

Many alpine ski areas have recently adopted voluntary environmental programs (VEPs) such as using recycling, renewable energy, and biofuels to help reduce their environmental impacts. Studies have addressed the performance of these VEPs in mitigating environmental impacts of this industry, but little is known about visitor awareness and perceptions of these programs. This article addresses this knowledge gap by exploring skier and snowboarder knowledge of VEPs at a ski area and the influence of these programs on their motivations to visit this area currently and behavioral intentions to visit again in the future. Data were obtained from an onsite survey at the Mt. Bachelor ski area in Oregon, USA (n = 429, 89.7% response rate). Few skiers and snowboarders were knowledgeable of VEPs at this area and fewer than 20% were motivated to visit on their current trip because of these programs. Other attributes such as scenery, snow conditions, and access were more important for influencing visitation. Up to 38% of skiers and snowboarders, however, intend to visit this ski area more often if it adopts and promotes more VEPs. Managers can use these results to inform communication and marketing of their environmental programs and performance to visitors. Additional implications for management and future research are discussed.

Home advantage in the Winter Olympics (1908-1998).

PubMed

Balmer, N J; Nevill, A M; Williams, A M

2001-02-01

We obtained indices of home advantage, based on the medals won by competing nations, for each event held at the Winter Olympics from 1908 to 1998. These indices were designed to assess home advantage while controlling for nation strength, changes in the number of medals on offer and the performance of 'non-hosting' nations. Some evidence of home advantage was found in figure skating, freestyle skiing, ski jumping, alpine skiing and short track speed skating. In contrast, little or no home advantage was observed in ice hockey, Nordic combined, Nordic skiing, bobsled, luge, biathlon or speed skating. When all events were combined, a significant home advantage was observed (P = 0.029), although no significant differences in the extent of home advantage were found between events (P > 0.05). When events were grouped according to whether they were subjectively assessed by judges, significantly greater home advantage was observed in the subjectively assessed events (P = 0.037). This was a reflection of better home performances, suggesting that judges were scoring home competitors disproportionately higher than away competitors. Familiarity with local conditions was shown to have some effect, particularly in alpine skiing, although the bobsled and luge showed little or no advantage over other events. Regression analysis showed that the number of time zones and direction of travel produced no discernible trends or differences in performance.

Biomechanical and energetic determinants of technique selection in classical cross-country skiing.

PubMed

Pellegrini, Barbara; Zoppirolli, Chiara; Bortolan, Lorenzo; Holmberg, Hans-Christer; Zamparo, Paola; Schena, Federico

2013-12-01

Classical cross-country skiing can be performed using three main techniques: diagonal stride (DS), double poling (DP), and double poling with kick (DK). Similar to other forms of human and animal gait, it is currently unclear whether technique selection occurs to minimize metabolic cost or to keep some mechanical factors below a given threshold. The aim of this study was to find the determinants of technique selection. Ten male athletes roller skied on a treadmill at different slopes (from 0° to 7° at 10km/h) and speeds (from 6 to 18km/h at 2°). The technique preferred by skiers was gathered for every proposed condition. Biomechanical parameters and metabolic cost were then measured for each condition and technique. Skiers preferred DP for skiing on the flat and they transitioned to DK and then to DS with increasing slope steepness, when increasing speed all skiers preferred DP. Data suggested that selections mainly occur to remain below a threshold of poling force. Second, critically low values of leg thrust time may limit the use of leg-based techniques at high speeds. A small role has been identified for the metabolic cost of locomotion, which determined the selection of DP for flat skiing. Copyright © 2013 Elsevier B.V. All rights reserved.

Effect of a skiing intervention on the psycho-physiological reactivity and recovery in the elderly.

PubMed

Finkenzeller, T; Müller, E; Amesberger, G

2011-08-01

This study determined the effects of a skiing intervention lasting 12 weeks on the psycho-physiological reactivity to and recovery from mental stressors in individuals who are 60+ years of age. In accordance with the cross-stressor hypothesis, it was assumed that a skiing intervention optimizes psycho-physiological pre-conditions for coping with stress. A cognitive task was used to investigate stress-induced changes (reactivity) in the high-frequency (HF) component of the heart rate variability (HRV) and in the skin conductance level (SCL) as well as recovery from this stressor. The intervention group demonstrated a significant increase in maximal oxygen consumption that was not accompanied by alterations in HRV at rest. In comparison with the control group, there was no difference in the alteration of the reactivity and recovery in the HF component and in the SCL after completing the training. The findings indicate that neither the psycho-physiological reactivity nor the recovery was influenced by the skiing intervention. It may be speculated that the intensity of the skiing intervention was too low to induce such adaptations. Therefore, further studies are encouraged to enhance the duration and intensity of the exercises to achieve adaptations of the autonomous nervous system of elderly individuals. © 2011 John Wiley & Sons A/S.

Alpine Skiing With total knee ArthroPlasty (ASWAP): metabolism, inflammation, and skeletal muscle fiber characteristics.

PubMed

Kristensen, M; Pötzelsberger, B; Scheiber, P; Bergdahl, A; Hansen, C N; Andersen, J L; Narici, M; Salvioli, S; Conte, M; Müller, E; Dela, F

2015-08-01

We investigated the effect of alpine skiing for 12 weeks on skeletal muscle characteristics and biomarkers of glucose homeostasis and cardiovascular risk factors. Twenty-three patients with a total knee arthroplasty (TKA) were studied 2.9 ± 0.9 years (mean ± SD) after the operation. Fourteen patients participated in the intervention group (IG) and nine in the control group (CG). Blood samples and muscle biopsies were obtained before (PRE) and 7.3 ± 0.8 days after (POST) the intervention, and blood samples again after a retention (RET) phase of 8 weeks. With skiing, glucose homeostasis improved in IG (decrease in fasting insulin, increase in muscle glycogen) but not in CG. Fiber type distribution and size, as well as capillary density and number of capillaries around the fibers (CAF), were not different between the operated and the non-operated leg in either group. The relative number of type I fibers increased with skiing in IG with no change in CG. Inflammatory biomarkers, plasma lipids, and mitochondrial proteins and activity did not change. Alpine skiing is metabolically beneficial and can be used as a training modality by elderly people with TKA. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Cardiorespiratory endurance evaluation using heart rate analysis during ski simulator exercise and the Harvard step test in elementary school students.

PubMed

Lee, Hyo Taek; Roh, Hyo Lyun; Kim, Yoon Sang

2016-01-01

[Purpose] Efficient management using exercise programs with various benefits should be provided by educational institutions for children in their growth phase. We analyzed the heart rates of children during ski simulator exercise and the Harvard step test to evaluate the cardiopulmonary endurance by calculating their post-exercise recovery rate. [Subjects and Methods] The subjects (n = 77) were categorized into a normal weight and an overweight/obesity group by body mass index. They performed each exercise for 3 minutes. The cardiorespiratory endurance was calculated using the Physical Efficiency Index formula. [Results] The ski simulator and Harvard step test showed that there was a significant difference in the heart rates of the 2 body mass index-based groups at each minute. The normal weight and the ski-simulator group had higher Physical Efficiency Index levels. [Conclusion] This study showed that a simulator exercise can produce a cumulative load even when performed at low intensity, and can be effectively utilized as exercise equipment since it resulted in higher Physical Efficiency Index levels than the Harvard step test. If schools can increase sport durability by stimulating students' interests, the ski simulator exercise can be used in programs designed to improve and strengthen students' physical fitness.

Spinal column and spinal cord injuries in mountain bikers: a 13-year review.

PubMed

Dodwell, Emily R; Kwon, Brian K; Hughes, Barbara; Koo, David; Townson, Andrea; Aludino, Allan; Simons, Richard K; Fisher, Charles G; Dvorak, Marcel F; Noonan, Vanessa K

2010-08-01

Multiple studies have described in general the injuries associated with mountain biking, and detailed accounts of spine injuries sustained in hockey, gymnastics, skiing, snowboarding, rugby, and paragliding have previously been published. However, no large-scale detailed assessment of mountain biking associated spinal fractures and spinal cord injuries has previously been published. This study was undertaken to describe the patient demographics, injuries, mechanisms, treatments, outcomes, and resource requirements associated with spine injuries sustained while mountain biking. Case series; Level of evidence, 4. Patients who were injured while mountain biking, and who were seen at a provincial spine referral center between 1995 and 2007 inclusive, with spinal cord injuries and/or spine fracture were included. A chart review was performed to obtain demographic data, and details of the injury, treatment, outcome, and resource requirements. A total of 102 men and 5 women were identified for inclusion. The mean age at injury was 32.7 years (95% confidence interval 30.6, 35.0). Seventy-nine patients (73.8%) sustained cervical injuries, while the remainder sustained thoracic or lumbar injuries. Forty-three patients (40.2%) sustained a spinal cord injury. Of those with cord injuries, 18 (41.9%) were American Spinal Injury Association (ASIA) A, 5 (11.6%) were ASIA B, 10 (23.3%) ASIA C, and 10 (23.3%) ASIA D. Sixty-seven patients (62.6%) required surgical treatment. The mean length of stay in an acute hospital bed was 16.9 days (95% confidence interval 13.1, 30.0). Thirty-three patients (30.8%) required intensive care unit attention, and 31 patients (29.0%) required inpatient rehabilitation. Of the 43 patients (40.2%) seen with spinal cord injuries, 14 (32.5%) improved by 1 ASIA category, and 1 (2.3%) improved by 2 ASIA categories. Two patients remained ventilator-dependent at discharge. Spine fractures and spinal cord injuries caused by mountain biking accidents typically affect young, male, recreational riders. The medical, personal, and societal costs of these injuries are high. Injury prevention should remain a primary goal, and further research is necessary to explore the utility of educational programs, and the effect of helmets and other protective gear on spine injuries sustained while mountain biking.

Return to sports after plate fixation of humeral head fractures 65 cases with minimum 24-month follow-up.

PubMed

Ahrens, Philipp; Martetschläger, Frank; Siebenlist, Sebastian; Attenberger, Johann; Crönlein, Moritz; Biberthaler, Peter; Stöckle, Ulrich; Sandmann, Gunther H

2017-04-26

Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding their sporting activities after surgically treated humeral head fractures. Despite a long rehabilitation program physical activities will change and an avoidance of overhead activities will be noticed. Case series with 65 Patients, with a minimum follow-up of 24 months participated in this study. All patients were treated using a locking plate fixation. Their sporting activity was investigated at the time of the injury and re-investigated after an average of 3.83 years. The questionnaire setup included the evaluation of shoulder function, sporting activities, intensity, sport level and frequency evaluation. Level of evidence IV. At the time of injury 61 Patients (94%) were engaged in recreational sporting activities. The number of sporting activities declined from 26 to 23 at the follow-up examination. There was also a decline in sports frequency and duration of sports activities. The majority of patients remains active in their recreational sporting activity at a comparable duration and frequency both pre- and postoperatively. Nevertheless, shoulder centered sport activities including golf, water skiing and martial arts declined or were given up.

Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis.

PubMed

Yuan, Xiaodong; Li, Dawei; Chen, Xiaosong; Han, Conghui; Xu, Longmei; Huang, Tao; Dong, Zhen; Zhang, Ming

2017-12-11

Renal ischemia-reperfusion is a main cause of acute kidney injury (AKI), which is associated with high mortality. Here we show that extracellular vesicles (EVs) secreted from hiPSC-MSCs play a critical role in protection against renal I/R injury. hiPSC-MSCs-EVs can fuse with renal cells and deliver SP1 into target cells, subsequently active SK1 expression and increase S1P formation. Chromatin immunoprecipitation (ChIP) analyses and luciferase assay were used to confirm SP1 binds directly to the SK1 promoter region and promote promoter activity. Moreover, SP1 inhibition (MIT) or SK1 inhibition (SKI-II) completely abolished the renal protective effect of hiPSC-MSCs-EVs in rat I/R injury mode. However, pre-treatment of necroptosis inhibitor Nec-1 showed no difference with the administration of hiPSC-MSCs-EVs only. We then generated an SP1 knockout hiPSC-MSC cell line by CRISPR/Cas9 system and found that SP1 knockout failed to show the protective effect of hiPSC-MSCs-EVs unless restoring the level of SP1 by Ad-SP1 in vitro and in vivo. In conclusion, this study describes an anti-necroptosis effect of hiPSC-MSCs-EVs against renal I/R injury via delivering SP1 into target renal cells and intracellular activating the expression of SK1 and the generation of S1P. These findings suggest a novel mechanism for renal protection against I/R injury, and indicate a potential therapeutic approach for a variety of renal diseases and renal transplantation.

A description of the severity of equestrian-related injuries (ERIs) using clinical parameters and patient-reported outcomes.

PubMed

Papachristos, Alexander; Edwards, Elton; Dowrick, Adam; Gosling, Cameron

2014-09-01

Despite a number of injury prevention campaigns and interventions, horse riding continues to be a dangerous activity, resulting in more accidents per hour than motorcycling, skiing and football. Injuries are often serious, with one in four patients requiring admission to hospital. This study aims to describe the severity of equestrian-related injuries (ERIs) using both clinical parameters and patient-reported outcomes. A retrospective study of all patients aged ≥18 years admitted to The Alfred Hospital between January 2003 and January 2008 with an ERI was performed. Specific clinical data were extracted from the medical record. In addition, a questionnaire was conducted identifying the details of the accident, the required recovery time and levels of ongoing pain and physical disability. During the study period 172 patients met the inclusion criteria. There were three deaths (2%). Eighty-two patients (48%) suffered head injuries. Forty-one patients (24%) were admitted to the ICU and 31 patients (18%) required mechanical ventilation. On discharge, 41 patients (24%) required transfer to a sub-acute rehabilitation facility. One-hundred-and-twenty-four patients (72%) completed the questionnaire. Thirty-nine respondents (31%) were not wearing a helmet. Among patients injured for more than 6 months, 38 (35%) still experienced moderate or severe pain or disability. Ninety-five patients had returned to work at the time of review, among which 47(50%) required longer than 6 months to recover, and 40 (42%) returned at a reduced capacity. The clinical and patient-reported outcomes of ERIs requiring hospital admission are poor. Persistent pain and disability are common, even up to 5 years post-injury. A large proportion of patients required longer than 6 months to return to work and many return at a reduced capacity. Copyright © 2014 Elsevier Ltd. All rights reserved.

78 FR 45061 - Safety Zone; Sister Bay Marina Fest Fireworks and Ski Show, Sister Bay, WI

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-26

... involved in the ski show. C. Discussion of the Final Rule With the aforementioned hazards in mind, the... on the human environment. This rule involves the establishment of a safety zone and, therefore it is...

France and Portugal in the Spanish Civil War - Domestic and International Policies

DTIC Science & Technology

1988-12-01

to fear from the spread of Spanish anarchy. The Portuguese had historically regarded Spain as the traditional enemy based on Spain’s past attempt to...Salazar’s crusade prompted drastic military reactions that, like the French Communist Party, greatly affected the outcome of the war. The Portuguese ...was decided that 130 British observers would patrol the Spanish- Portuguese border, another 130 undetermined observers would patrol the Franco-Spanish 3

Physiological Stresses Related to Hypercapnia during Patrols on Submarines

DTIC Science & Technology

1975-12-01

Acid- base balance, CO., storage, and calcium homeostasis | I am trying to show that this delayed renal response in low level chronic hypercapnia is 1...C02 Co, P BONE 4 1 BLOOD Fig. 11. Cycles in acid- base balance, bone buffering, and renal regulation during prolonged exposure to 0.7...patrols on submarines K. E. SCHAEFER Naval Submarine Medical Research Laboratory, Naval Submarine Base . Groton. CT 06340 Schaefer, K. E. 1979

A New Catalog of Contact Binary Stars from ROTSE-I Sky Patrols

NASA Astrophysics Data System (ADS)

Gettel, S. J.; McKay, T. A.; Geske, M. T.

2005-05-01

Over 65,000 variable stars have been detected in the data from the ROTSE-I Sky Patrols. Using period-color and light curve selection techniques, about 5000 objects have been identified as contact binaries. This selection is tested for completeness against EW objects in the GCVS. By utilizing infrared color data from 2MASS, we fit a period-color-luminosity relation to these stars and estimate their distances.

Bio-inspired group modeling and analysis for intruder detection in mobile sensor/robotic networks.

PubMed

Fu, Bo; Xiao, Yang; Liang, Xiannuan; Philip Chen, C L

2015-01-01

Although previous bio-inspired models have concentrated on invertebrates (such as ants), mammals such as primates with higher cognitive function are valuable for modeling the increasingly complex problems in engineering. Understanding primates' social and communication systems, and applying what is learned from them to engineering domains is likely to inspire solutions to a number of problems. This paper presents a novel bio-inspired approach to determine group size by researching and simulating primate society. Group size does matter for both primate society and digital entities. It is difficult to determine how to group mobile sensors/robots that patrol in a large area when many factors are considered such as patrol efficiency, wireless interference, coverage, inter/intragroup communications, etc. This paper presents a simulation-based theoretical study on patrolling strategies for robot groups with the comparison of large and small groups through simulations and theoretical results.

A 2D chaotic path planning for mobile robots accomplishing boundary surveillance missions in adversarial conditions

NASA Astrophysics Data System (ADS)

Curiac, Daniel-Ioan; Volosencu, Constantin

2014-10-01

The path-planning algorithm represents a crucial issue for every autonomous mobile robot. In normal circumstances a patrol robot will compute an optimal path to ensure its task accomplishment, but in adversarial conditions the problem is getting more complicated. Here, the robot’s trajectory needs to be altered into a misleading and unpredictable path to cope with potential opponents. Chaotic systems provide the needed framework for obtaining unpredictable motion in all of the three basic robot surveillance missions: area, points of interests and boundary monitoring. Proficient approaches have been provided for the first two surveillance tasks, but for boundary patrol missions no method has been reported yet. This paper addresses the mentioned research gap by proposing an efficient method, based on chaotic dynamic of the Hénon system, to ensure unpredictable boundary patrol on any shape of chosen closed contour.

The dangerousness of mountain recreation: A quantitative overview of fatal and non-fatal accidents in France.

PubMed

Soulé, Bastien; Lefèvre, Brice; Boutroy, Eric

2017-08-01

In France, there is a growing enthusiasm for outdoor sports and recreation. In the meantime, the risk of both severe and frequent injury associated with active pursuits in mountain areas is acknowledged. This paper tackles accidents related to mountain sports, with a focus on three critical activities: hiking, mountaineering and ski touring. The aim consists of estimating the actual number of accidents (whether they entailed deaths or injuries) in the three above-mentioned activities. In order to align the information collected, then provide estimations based on the reasoned crossing of these secondary data, we consulted and summarised all the databases available on the French territory. Results address the trauma-related mortality in absolute values, and a comparison with the death rate of other sports. The calculation of a mortality index, including secondary mortality, is then provided. Elements of mountain sports accidentality are also presented, intending to clarify how many casualities occur each year in the French mountains. Last, a focus on the particularities of each mountain sport is provided.

Sports Injury-Related Fingers and Thumb Deformity Due to Tendon or Ligament Rupture.

PubMed

Bai, Rong-Jie; Zhang, Hui-Bo; Zhan, Hui-Li; Qian, Zhan-Hua; Wang, Nai-Li; Liu, Yue; Li, Wen-Ting; Yin, Yu-Ming

2018-05-05

Hand injuries are very common in sports, such as skiing and ball sports. One of the major reasons causing hand and finger deformity is due to ligament and tendon injury. The aim of this study was to investigate if the high-resolution 3T magnetic resonance imaging (MRI) can demonstrate the complex anatomy of the fingers and thumb, especially the tendons and ligaments, and provide the accurate diagnosis of clinically important fingers and thumbs deformity due to ligamentous and tendinous injuries during sport activities. Sixteen fresh un-embalmed cadaveric hands were harvested from eight cadavers. A total of 20 healthy volunteers' hands and 44 patients with fingers or thumb deformity due to sports-related injuries were included in this study. All subjects had MR examination with T1-weighted images and proton density-weighted imaging with fat suppression (PD FS) in axial, coronal, and sagittal plane, respectively. Subsequently, all 16 cadaveric hands were sliced into 2-mm thick slab with a band saw (six in coronal plane, six in sagittal plane, and four in axial plane). The correlation of anatomic sections and the MRI characteristics of tendons of fingers and the ulnar collateral ligament (UCL) at the metacarpal phalangeal joint (MCPJ) of thumb between 20 healthy volunteers and 44 patients (confirmed by surgery) were analyzed. The normal ligaments and tendons in 16 cadaveric hands and 20 volunteers' hands showed uniform low-signal intensity on all the sequences of the MRI. Among 44 patients with tendinous and ligamentous injuries in the fingers or thumb, 12 cases with UCL injury at MCPJ of the thumb (Stener lesion = 8 and non-Stener lesion = 4), 6 cases with the central slip injury, 12 cases with terminal tendon injury, and 14 cases with flexor digitorum profundus injury. The ligaments and tendons disruption manifested as increased signal intensity and poor definition, discontinuity, and heterogeneous signal intensity of the involved ligaments and tendons. Sports injury-related fingers and thumb deformity are relatively common. MRI is an accurate method for evaluation of the anatomy and pathologic conditions of the fingers and thumb. It is a useful tool for accurate diagnosis of the sports-related ligaments and tendons injuries in hand.

Intra-articular temperatures of the knee in sports – An in-vivo study of jogging and alpine skiing

PubMed Central

Becher, Christoph; Springer, Jan; Feil, Sven; Cerulli, Guiliano; Paessler, Hans H

2008-01-01

Background Up to date, no information exists about the intra-articular temperature changes of the knee related to activity and ambient temperature. Methods In 6 healthy males, a probe for intra-articular measurement was inserted into the notch of the right knee. Each subject was jogging on a treadmill in a closed room at 19°C room temperature and skiing in a ski resort at -3°C outside temperature for 60 minutes. In both conditions, temperatures were measured every fifteen minutes intra-articulary and at the skin surface of the knee. A possible influence on joint function and laxity was evaluated before and after activity. Statistical analysis of intra-articular and skin temperatures was done using nonparametric Wilcoxon's sign rank sum test and Mann-Whitney's-U-Test. Results Median intra-articular temperatures increased from 31.4°C before activity by 2.1°C, 4°C, 5.8°C and 6.1°C after 15, 30, 45 and 60 min of jogging (all p ≤ 0.05). Median intra-articular temperatures dropped from 32.2°C before activity by 0.5°C, 1.9°C, 3.6°C and 1.1°C after 15, 30, 45 and 60 min of skiing (all n.s.). After 60 minutes of skiing (jogging), the median intra-articular temperature was 19.6% (8.7%) higher than the skin surface temperature at the knee. Joint function and laxity appeared not to be different before and after activity within both groups. Conclusion This study demonstrates different changes of intra-articular and skin temperatures during sports in jogging and alpine skiing and suggests that changes are related to activity and ambient temperature. PMID:18405365

Grade influences blood lactate kinetics during cross-country skiing.

PubMed

LaRoche, Dain P; Amann, Markus; Rundell, Kenneth W

2010-01-01

The purpose of this study was to examine the effects of level vs. graded skate skiing on capillary blood lactate (B(La)), heart rate (HR), oxygen consumption (V(O2)), and training intensity prescriptions. Eleven Nordic skiers completed 2 submaximal skate roller skiing treadmill protocols during which intensity was increased either by grade (G(inc)) or by speed (S(inc)). The protocols were compared for prethreshold BLa, HR, and V(O2) at lactate threshold (LT) and the HR/V(O2) relationship. Additionally, double-pole (primarily upper body) and skating (arms and legs combined) protocols were used to measure peak V(O2) and peak HR. Heart rate and V(O2) at LT were lower during G(inc) compared with S(inc) (154.9 +/- 6.8 b.min(-1) vs. 162.0 +/- 9.1 b.min(-1) and 46.3 +/- 2.8 ml.kg(-1).min(-1) vs. 49.1 +/- 1.6 ml.kg(-1).min(-1), respectively, both p < 0.01). Pre-threshold B(La) and the HR/V(O2) relationship were not different between the submaximal protocols. V(O2) and HRpeak were higher in skating compared with double poling (64.6 +/- 1.8 ml.kg(-1).min(-1) vs. 60.3 +/- 2.8 ml.kg(-1).min(-1), 192.6 +/- 5.8 b.min(-1) vs. 187.8 +/- 6.7 b.min(-1), respectively, both p < 0.01). Greater reliance on upper-body musculature during graded skiing and its associated lower aerobic capacity increases B(La) when compared with level skiing. The leftward shift in the B(La) vs. intensity curve during uphill skiing should be recognized to properly prescribe training intensity as well as interpret laboratory results.