Astronaut Owen Garriott at the Apollo Telescope Mount console

NASA Image and Video Library

1973-08-08

Scientist-Astronaut Owen K. Garriott, science pilot of the Skylab 3 mission, is stationed at the Apollo Telescope Mount (ATM) console in the Multiple Docking Adapter of the Skylab space station in Earth orbit. From this console the astronauts actively control the ATM solar physics telescope.

SKYLAB (SL)-4 - CREW TRAINING (ORBITAL WORKSTATION [OWS]) - JSC

NASA Image and Video Library

1973-08-22

S73-32847 (10 Sept. 1973) --- Astronaut Gerald P. Carr, Skylab 4 commander, changes a dial on the control and display panel for the Earth Resources Experiments package (EREP) during a training exercise in the Multiple Docking Adapter (MDA) one-G trainer at Johnson Space Center. Photo credit: NASA

Skylab

NASA Image and Video Library

1972-09-01

The Multiple Docking Adapter (MDA), designed and constructed under the direction of the Marshall Space Flight Center, was one of four principal sections comprising Skylab. The MDA provided the means by which the Command and Service Modules attached to the Skylab, enabling the crews to enter and work in it. Also included in the MDA was a control and display console for the Apollo Telescope Mount. This image shows an interior view of the MDA.

SKYLAB (SL)-3 CREW - TRAINING - ORBITAL WORKSHOP (OWS) TRAINER - JSC

NASA Image and Video Library

1973-06-19

S73-28411 (February 1973) --- The three members of the prime crew of the third of three scheduled manned Skylab missions (Skylab 4) go through Skylab preflight training in the Mission Training and Simulation Facility at the Johnson Space Center. Astronaut Gerald P. Carr (on right), Skylab 4 commander, is seated at a simulator which represents the control and display console of the Apollo Telescope Mount which is located in the space station's Multiple Docking Adapter. Seated on the left is scientist-astronaut Edward G. Gibson, Skylab 4 science pilot. In the left background is astronaut William R. Pogue, Skylab 4 pilot. (Unmanned Skylab 1 will carry the Skylab space station payload into Earth orbit). Photo credit: NASA

SKYLAB (SL)-3 - EXPERIMENT HARDWARE

NASA Image and Video Library

1973-11-08

S74-19675 (1974) --- Medium close-up view of the M512 materials processing equipment storage assembly and the M518 electric furnace in the Multiple Docking Adapter (MDA), one of the primary elements of the Skylab space station. The assembly holds equipment designed to explore space manufacturing capability in a weightless state. Photo credit: NASA

SKYLAB (SL)-4 - CREW TRAINING (ORBITAL WORKSHOP [OWS]) - JSC

NASA Image and Video Library

1973-08-22

S73-32839 (10 Sept. 1973) --- Scientist-astronaut Edward G. Gibson, science pilot for the third manned Skylab mission (Skylab 4), enters a notation in a manual while seated at the control and display panel for the Apollo Telescope Mount (ATM) during simulations inside the one-G trainer for the Multiple Docking Adapter (MDA) at the Johnson Space Center (JSC). Dr. Gibson will be joined by astronauts Gerald P. Carr, commander, and William R. Pogue, pilot, when the Skylab 4 mission begins in November 1973. Photo credit: NASA

Spacelab

NASA Image and Video Library

1970-11-01

At Marshall Space Flight Center, Skylab's Multiple Docking Adapter (MDA) flight article undergoes center-of-gravity testing. Developed and fabricated by MSFC, the MDA housed the control units for the Apollo Telescope Mount (ATM), Earth Resources Experiment Package (EREP), and the Zero-Gravity Material Processing Facility and provided a docking port for the Apollo Command Module.

SKYLAB (SL)-3 - TELEVISION (EXTRAVEHICULAR ACTIVITY [EVA])

NASA Image and Video Library

1973-08-27

S73-33161 (24 Aug. 1973) --- Astronaut Jack R. Lousma, Skylab 3 pilot, hooks up a 23-foot, two-inch connecting cable for the rate gyro six pack during extravehicular activity (EVA) on Aug. 24, 1973, as seen in this photographic reproduction taken from a color television transmission made by a TV camera aboard the Skylab space station in Earth orbit. The rate gyros were mounted inside the Multiple Docking Adapter opposite the Apollo Telescope Mount control and display console. Photo credit: NASA

SKYLAB (SL) PRIME CREW - BLDG. 5 - JSC

NASA Image and Video Library

1973-03-20

S73-20759 (1 March 1973) --- Astronaut Charles Conrad Jr., commander of the first manned Skylab mission, takes items from the M512 materials processing equipment storage assembly during Skylab training at Johnson Space Center. Conrad is standing in the Multiple Docking Adapter (MDA) trainer in the JSC Mission Simulation and Training Facility. The assembly holds equipment designed to explore space manufacturing capability in a weightless state. Conrad is holding one of the experiment parts in his left hand. Photo credit: NASA

Skylab

NASA Image and Video Library

1972-01-01

This photograph shows the flight article of the Airlock Module (AM)/Multiple Docking Adapter (MDA) assembly being readied for testing in a clean room at the McDornell Douglas Plant in St. Louis, Missouri. Although the AM and the MDA were separate entities, they were in many respects simply two components of a single module. The AM enabled crew members to conduct extravehicular activities outside Skylab as required for experiment support. Oxygen and nitrogen storage tanks needed for Skylab's life support system were mounted on the external truss work of the AM. Major components in the AM included Skylab's electric power control and distribution station, environmental control system, communication system, and data handling and recording systems. The MDA, forward of the AM, provided docking facilities for the Command and Service Module. It also accommodated several experiment systems, among them the Earth Resource Experiment Package, the materials processing facility, and the control and display console needed for the Apollo Telescope Mount solar astronomy studies. The AM was built by McDonnell Douglas and the MDA was built by Martin Marietta. The Marshall Space Flight Center was responsible for the design and development of the Skylab hardware and experiment management.

Skylab

NASA Image and Video Library

1972-03-01

This photograph shows the flight article of the mated Airlock Module (AM) and Multiple Docking Adapter (MDA) being lowering into horizontal position on a transporter. Although the AM and the MDA were separate entities, they were in many respects simply two components of a single module. The AM enabled crew members to conduct extravehicular activities outside Skylab as required for experiment support. Oxygen and nitrogen storage tanks needed for Skylab's life support system were mounted on the external truss work of the AM. Major components in the AM included Skylab's electric power control and distribution station, environmental control system, communication system, and data handling and recording systems. The MDA, forward of the AM, provided docking facilities for the Command and Service Module. It also accommodated several experiment systems, among them the Earth Resource Experiment Package, the materials processing facility, and the control and display console needed for the Apollo Telescope Mount solar astronomy studies. The AM was built by McDornell Douglas and the MDA was built by Martin Marietta. The Marshall Space Flight Center was responsible for the design and development of the Skylab hardware and experiment management.

Skylab

NASA Image and Video Library

1967-01-01

This photograph is of a model of the Skylab with the Command/Service Module being docked. In an early effort to extend the use of Apollo for further applications, NASA established the Apollo Applications Program (AAP) in August of 1965. The AAP was to include long duration Earth orbital missions during which astronauts would carry out scientific, technological, and engineering experiments in space by utilizing modified Saturn launch vehicles and the Apollo spacecraft. Established in 1970, the Skylab Program was the forerurner of the AAP. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

Skylab

NASA Image and Video Library

1971-01-01

This illustration depicts the Skylab-1 and Skylab-2 mission sequence. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

Skylab

NASA Image and Video Library

1972-01-01

This chart details Skylab's Materials Processing Facility experiment (M512). This facility, located in the Multiple Docking Adapter, was developed for Skylab and accommodated 14 different experiments that were carried out during the three marned missions. The abilities to melt and mix without the contaminating effects of containers, to suppress thermal convection and buoyancy in fluids, and to take advantage of electrostatic and magnetic forces and otherwise masked by gravitation opened the way to new knowledge of material properties and processes. This beginning would ultimately lead to the production of valuable new materials for use on Earth.

Material Processing Facility - Skylab Experiment M512

NASA Technical Reports Server (NTRS)

1972-01-01

This chart details Skylab's Materials Processing Facility experiment (M512). This facility, located in the Multiple Docking Adapter, was developed for Skylab and accommodated 14 different experiments that were carried out during the three marned missions. The abilities to melt and mix without the contaminating effects of containers, to suppress thermal convection and buoyancy in fluids, and to take advantage of electrostatic and magnetic forces and otherwise masked by gravitation opened the way to new knowledge of material properties and processes. This beginning would ultimately lead to the production of valuable new materials for use on Earth.

Skylab

NASA Image and Video Library

1974-01-01

This photograph shows the Skylab Materials Processing Facility (M512) and the Multipurpose Furnace System (M518). This facility, located in the Multiple Docking Adapter, was developed for Skylab and accommodated 14 different experiments that were carried out during the three marned missions. The abilities to melt and mix without the contaminating effects of containers, to suppress thermal convection and buoyancy in fluids, and to take advantage of electrostatic and magnetic forces and otherwise masked by gravitation opened the way to new knowledge of material properties and processes. This beginning would ultimately lead to the production of valuable new materials for use on Earth.

Skylab

NASA Image and Video Library

1974-01-01

This photograph shows the Skylab Materials Processing Facility (M512) and the Multipurpose Furnace System (M518). This facility, located in the Multiple Docking Adapter, was developed for Skylab,and accommodated 14 different experiments that were carried out during the three marned missions. The abilities to melt and mix without the contaminating effects of containers, to suppress thermal convection and buoyancy in fluids, and to take advantage of electrostatic and magnetic forces and otherwise masked by gravitation opened the way to new knowledge of material properties and processes. This beginning would ultimately lead to the production of valuable new materials for use on Earth.

Astronaut Jack Lousma hooks up cable for rate gyro six pack during EVA

NASA Technical Reports Server (NTRS)

1973-01-01

Astronaut Jack R. Lousma, Skylab 3 pilot, hooks up a 23 ft. 2 in. connecting cable for the rate gyro six pack during extravehicular activity (EVA) on August 24, 1973, as senn in this photographic reproduction taken from a color television tranmsission made by a TV camera aboard the Skylab space station in Earth orbit. The rate gyros were mounted inside the Multiple Docking Adapter opposite the Apollo Telescope Mount control and display console.

Skylab

NASA Image and Video Library

1972-01-01

This photograph depicts the flight article of the Airlock Module (AM) Flight Article being mated to the Fixed Airlock Shroud and aligned in a clean room of the McDornell Douglas Plant in St. Louis, Missouri. The AM enabled crew members to conduct extravehicular activities outside Skylab as required for experiment support. Separated from the Workshop and the Multiple Docking Adapter by doors, the AM could be evacuated for egress or ingress of a space-suited astronaut through a side hatch. Oxygen and nitrogen storage tanks needed for Skylab's life support system were mounted on the external truss work of the AM. Major components in the AM included Skylab's electric power control and distribution station, environmental control system, communication system, and data handling and recording systems. The Marshall Space Flight Center was responsible for the design and development of the Skylab hardware and experiment management.

SL3-108-01288

NASA Image and Video Library

1973-07-01

SL3-108-1288 (July-Sept. 1973) --- Astronaut Owen K. Garriott, science pilot of the Skylab 3 mission, is stationed at the Apollo Telescope Mount (ATM) console in the Multiple Docking Adapter (MDA) of the Skylab space station in Earth orbit. This picture was taken with a handheld 35mm Nikon camera. Astronauts Garriott, Alan L. Bean and Jack R. Lousma remained with the Skylab space station cluster in orbit for 59 days conducting numerous medical, scientific and technological experiments. In orbit the MDA functions as a major experiment control center for solar observations. From this console the astronauts actively control the ATM solar physics telescopes. Photo credit: NASA

sl2-x9-747

NASA Image and Video Library

2013-09-10

SL2-X9-747 (June 1973) --- Astronaut Paul J. Weitz, Skylab 2 pilot, mans the control and display console of the Apollo Telescope Mount (ATM) in this onboard view photographed in Earth orbit. The ATM C&D console is located in the Multiple Docking Adapter (MDA) of the Skylab 1/2 space station. Weitz, along with astronaut Charles Conrad Jr., commander, and scientist-astronaut Joseph P. Kerwin, science pilot, went on to successfully complete a 28-day mission in Earth orbit. Photo credit: NASA

Skylab 3,Skylab as the CM moves in for docking

NASA Image and Video Library

1973-07-28

SL3-114-1683 (28 July 1973) --- A close-up view of the Skylab space station photographed against an Earth background from the Skylab 3 Command and Service Modules (CSM) during station-keeping maneuvers prior to docking. Aboard the Command Module (CM) were astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma, who remained with the Skylab Space Station in Earth orbit for 59 days. This picture was taken with a hand-held 70mm Hasselblad camera using a 100mm lens and SO-368 medium speed Ektachrome film. Note the one solar array system wing on the Orbital Workshop (OWS) which was successfully deployed during extravehicular activity (EVA) on the first manned Skylab flight. The parasol solar shield which was deployed by the Skylab 2 crew can be seen through the support struts of the Apollo Telescope Mount (ATM). Photo credit: NASA

Skylab (SL)-4 Astronauts - "Open House" Press Day - SL Mockup - MSC

NASA Image and Video Library

1972-01-20

S72-17512 (19 Jan. 1972) --- These three men are the crewmen for the first manned Skylab mission. They are astronaut Charles Conrad Jr., commander, standing left; scientist-astronaut Joseph P. Kerwin, seated; and astronaut Paul J. Weitz, pilot. They were photographed and interviewed during an "open house" press day in the realistic atmosphere of the Multiple Docking Adapter (MDA) trainer in the Mission Simulation and Training Facility at the Manned Spacecraft Center (MSC). The control and display panel for the Apollo Telescope Mount (ATM) is at right. Photo credit: NASA

SKYLAB II - Making a Deep Space Habitat from a Space Launch System Propellant Tank

NASA Technical Reports Server (NTRS)

Griffin, Brand N.; Smitherman, David; Kennedy, Kriss J.; Toups, Larry; Gill, Tracy; Howe, A. Scott

2012-01-01

Called a "House in Space," Skylab was an innovative program that used a converted Saturn V launch vehicle propellant tank as a space station habitat. It was launched in 1973 fully equipped with provisions for three separate missions of three astronauts each. The size and lift capability of the Saturn V enabled a large diameter habitat, solar telescope, multiple docking adaptor, and airlock to be placed on-orbit with a single launch. Today, the envisioned Space Launch System (SLS) offers similar size and lift capabilities that are ideally suited for a Skylab type mission. An envisioned Skylab II mission would employ the same propellant tank concept; however serve a different mission. In this case, the SLS upper stage hydrogen tank is used as a Deep Space Habitat (DSH) for NASA s planned missions to asteroids, Earth-Moon Lagrangian point and Mars.

Emblem - NASA Skylab (SL) Program

NASA Image and Video Library

1973-04-25

S73-23952 (May 1973) --- This is the official emblem for the National Aeronautics and Space Administration's (NASA) Skylab Program. The emblem depicts the United States Skylab space station cluster in Earth orbit with the sun in the background. Skylab will evaluate systems and techniques designed to gather information on Earth resources and environmental problems. Solar telescopes will increase man's knowledge of our sun and the multitude of solar influences on Earth environment. Medical experiments will increase knowledge of man himself and his relationship to his earthly environment and adaptability to spaceflight. Additionally, Skylab will experiment with industrial processes which may be enhanced by the unique weightless, vacuum environment of orbital spaceflight. The 100-ton laboratory complex Skylab space station is composed of the Command/Service Module (CSM), Orbital Workshop (OW), Apollo Telescope Mount (ATM), Multiple Docking Adapter (MDA), and Airlock Module (AM). The NASA insignia design for Skylab is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the form of illustrations by the various news media. When and if there is any change in this policy, which we do not anticipate, it will be publicly announced. Photo credit: NASA

Skylab 2 crew during "open house" press day at Manned Spacecraft Center (MSC)

NASA Image and Video Library

1972-01-19

S72-17509 (19 Jan. 1972) --- These three men are the crewmen for the first manned Skylab mission. They are astronaut Charles Conrad Jr., commander, standing left; scientist-astronaut Joseph P. Kerwin, seated; and astronaut Paul J. Weitz, pilot. They were photographed and interviewed during an "open house" press day in the realistic atmosphere of the Multiple Docking Adapter (MDA) trainer in the Mission Simulation and Training Facility at the Manned Spacecraft Center (MSC). The control and display panel for the Apollo Telescope Mount (ATM) is at right. Photo credit: NASA

Skylab

NASA Image and Video Library

1974-01-01

This image is an artist's concept of the Skylab in orbit. In an early effort to extend the use of Apollo for further applications, NASA established the Apollo Applications Program (AAP) in August of 1965. The AAP was to include long duration Earth orbital missions during which astronauts would carry out scientific, technological, and engineering experiments in space by utilizing modified Saturn launch vehicles and the Apollo spacecraft. Established in 1970, the Skylab program was the forerurner of the AAP. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

Skylab

NASA Image and Video Library

1971-01-01

This image illustrates major areas of emphasis of the Skylab Program. In an early effort to extend the use of Apollo for further applications, NASA established the Apollo Applications Program (AAP) in August of 1965. The AAP was to include long duration Earth orbital missions during which astronauts would carry out scientific, technological, and engineering experiments in space by utilizing modified Saturn launch vehicles and the Apollo spacecraft. Established in 1970, the Skylab Program was the forerurner of the AAP. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

View of the Skylab 1 space station cluster from the Skylab 2 Command Module

NASA Image and Video Library

1973-05-25

S73-26738 (25 May 1973) --- A close-up view of the Skylab 1 space station cluster can be seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 2 Command Module during its ?fly-around? inspection of the cluster. The numbers across the top of the picture indicate the Skylab 1 ground lapse time. Note the missing portion of the micrometeoroid shield on the Orbital Workshop. The shield area was reported to be solid gold by the Skylab 2 crewmen. A cable appears to be wrapped around the damaged OWS solar array system wing. The crewmen reported that the other OWS solar panel was completely gone, with only tubes and wiring sticking out. One of the discone antennas extends out form the Airlock Module. The Multiple Docking Adapter is in the lower left corner of the picture. A portion of a solar panel on the Apollo Telescope Mount is visible at the bottom and at the left edge. In their ?fly around? inspection the crewmen noted that portions of the micrometeoroid shield had slid back underneath the OWS solar wing. Photo credit: NASA

Skylab

NASA Image and Video Library

1972-12-21

Hans F. Wuenscher, assistant director for Advanced Space Projects Engineering Laboratory at Marshall Space Flight Center (MSFC), examined the facility to be used by Skylab astronauts in performing a number of experiments in material science and manufacturing in space. The equipment shown here is a duplicate of the M512 Experiment hardware flown in the Multiple Docking Adapter section of the Sky lab. This equipment, itself an experiment, was be used for conducting 5 other experiments in the round vacuum chamber. Inside was a cavity which held the M518 Multipurpose Electric Furnace, a facility which was used for conducting other experiments. In all, a total of 17 experiments were conducted using this facility and furnace.

Space Station/Skylab Sketch

NASA Technical Reports Server (NTRS)

1966-01-01

Seldom in aerospace history has a major decision been as promptly and concisely recorded as with the Skylab shown in this sketch. At a meeting at the Marshall Space Flight Center on August 19, 1966, George E. Mueller, NASA Associate Administrator for Marned Space Flight, used a felt pen and poster paper to pin down the final conceptual layout for the budding space station's (established as the Skylab in 1970) major elements. General Davy Jones, first program director, added his initials and those of Dr. Mueller in the lower right corner. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

Skylab

NASA Image and Video Library

1969-01-01

This cutaway drawing illustrates major Skylab components in launch configuration on top of the Saturn V. In an early effort to extend the use of Apollo for further applications, NASA established the Apollo Applications Program (AAP) in August of 1965. The AAP was to include long duration Earth orbital missions during which astronauts would carry out scientific, technological, and engineering experiments in space by utilizing modified Saturn launch vehicles and the Apollo spacecraft. Established in 1970, the Skylab Program was the forerurner of the AAP. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

Skylab

NASA Image and Video Library

1970-01-01

This illustration shows general characteristics of the Skylab with callouts of its major components. In an early effort to extend the use of Apollo for further applications, NASA established the Apollo Applications Program (AAP) in August of 1965. The AAP was to include long duration Earth orbital missions during which astronauts would carry out scientific, technological, and engineering experiments in space by utilizing modified Saturn launch vehicles and the Apollo spacecraft. Established in 1970, the Skylab Program was the forerurner of the AAP. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

Skylab

NASA Image and Video Library

1974-01-01

This image is an artist's concept of the Skylab in orbit with callouts of its major components. In an early effort to extend the use of Apollo for further applications, NASA established the Apollo Applications Program (AAP) in August of 1965. The AAP was to include long duration Earth orbital missions during which astronauts would carry out scientific, technological, and engineering experiments in space by utilizing modified Saturn launch vehicles and the Apollo spacecraft. Established in 1970, the Skylab Program was the forerurner of the AAP. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

Skylab

NASA Image and Video Library

1966-01-01

Seldom in aerospace history has a major decision been as promptly and concisely recorded as with the Skylab shown in this sketch. At a meeting at the Marshall Space Flight Center on August 19, 1966, George E. Mueller, NASA Associate Administrator for Marned Space Flight, used a felt pen and poster paper to pin down the final conceptual layout for the budding space station's (established as the Skylab in 1970) major elements. General Davy Jones, first program director, added his initials and those of Dr. Mueller in the lower right corner. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

Mojave Desert, California

NASA Image and Video Library

1973-06-22

SL2-03-126 (June 1973) --- A color infrared photograph of the Los Angeles County and Kern County area, taken from the Skylab space station in Earth orbit during its first manned Skylab mission. The Mojave Desert occupies the northeast one-fourth of the photograph. Lake Isabella in the Sierra Nevada Mountains is the v-shaped body of water. The San Gabriel Mountains extend across the southern part of the picture. At lower center is the intersection of the San Andreas and Garlock faults. The San Joaquin Valley is in the center at the left edge. (The picture should be held with the heavy cloud cover at lower right corner so that north will be at top.) This picture was exposed by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility experiment in the Multiple Docking Adapter of the Skylab space station. Type 2443 film was used. Photo credit: NASA

The Skylab Airlock Module

NASA Technical Reports Server (NTRS)

1972-01-01

This artist's concept is a cutaway illustration of the Skylab Airlock Module and its characteristics. The aft end of the Docking Adapter mated to the Airlock Module (AM), and served as the environmental, electrical, and communications control center. The docking adapter also contained the port through which the astronauts exited to perform extravehicular activity. The AM contained a turnel section through which Skylab crewmen could move between the workshop and the forward end of the airlock. It was encircled, for part of its length, at its aft end by the fixed Airlock Shroud (FAS), that had the same diameter as the workshop (22 feet) and was attached to the workshop's forward end. High pressure containers for oxygen and nitrogen providing Skylab's atmosphere, were mounted in the annular space between the outside of the tunnel and the inside of the shroud. The forward end of the FAS was the base on which the tubular structure supporting the solar observatory was mounted. Many of the supplies, and most of the control systems for Skylab were located in the AM; this module could well be the 'utility center' of the Skylab cluster. McDonnell Douglas fabricated the module with close Marshall Space Flight Center's involvement in design, development, and test activities.

Skylab

NASA Image and Video Library

1972-01-01

This artist's concept is a cutaway illustration of the Skylab Airlock Module and its characteristics. The aft end of the Docking Adapter mated to the Airlock Module (AM), and served as the environmental, electrical, and communications control center. The docking adapter also contained the port through which the astronauts exited to perform extravehicular activity. The AM contained a turnel section through which Skylab crewmen could move between the workshop and the forward end of the airlock. It was encircled, for part of its length, at its aft end by the fixed Airlock Shroud (FAS), that had the same diameter as the workshop (22 feet) and was attached to the workshop's forward end. High pressure containers for oxygen and nitrogen providing Skylab's atmosphere, were mounted in the annular space between the outside of the tunnel and the inside of the shroud. The forward end of the FAS was the base on which the tubular structure supporting the solar observatory was mounted. Many of the supplies, and most of the control systems for Skylab were located in the AM; this module could well be the "utility center" of the Skylab cluster. McDonnell Douglas fabricated the module with close Marshall Space Flight Center's involvement in design, development, and test activities.

Feasibility study of the solar scientific instruments for Spacelab/Orbiter

NASA Technical Reports Server (NTRS)

Leritz, J.; Rasser, T.; Stone, E.; Lockhart, B.; Nobles, W.; Parham, J.; Eimers, D.; Peterson, D.; Barnhart, W.; Schrock, S.

1981-01-01

The feasibility and economics of mounting and operating a set of solar scientific instruments in the backup Skylab Apollo Telescope Mount (ATM) hardware was evaluated. The instruments used as the study test payload and integrated into the ATM were: the Solar EUV Telescope/Spectrometer; the Solar Active Region Observing Telescope; and the Lyman Alpha White Light Coronagraph. The backup ATM hardware consists of a central cruciform structure, called the "SPAR', a "Sun End Canister' and a "Multiple Docking Adapter End Canister'. Basically, the ATM hardware and software provides a structural interface for the instruments; a closely controlled thermal environment; and a very accurate attitude and pointing control capability. The hardware is an identical set to the hardware that flow on Skylab.

SL2-04-118

NASA Image and Video Library

1973-06-01

SL2-04-118 (June 1973) --- A color photograph of the San Francisco Bay, California area, taken from the Skylab space station in Earth orbit. (The picture should be held with the clouds and Pacific Ocean on the left.) Note the thickly populated and highly developed area around the bay. Among the cities visible are San Francisco, Oakland, Berkeley and San Jose. This view extends eastward to show a portion of the San Joaquin Valley. This photograph was taken by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the space station. Type SO-356 film was used. The S190-A experiment is part of the Skylab Earth Resources Experiments Package (EREP). Photo credit: NASA

SKYLAB (SL)-III - LAUNCH - KSC

NASA Image and Video Library

1973-08-17

S73-32570 (28 July 1973) --- The Skylab 3/Saturn 1B space vehicle is launched from Pad B, Launch Complex 39, Kennedy Space Center, Florida, at 7:11 a.m. (EDT), Saturday, July 28, 1973. Skylab 3 is the second of three scheduled Skylab manned missions. Aboard the Skylab 3 Command/Service Module were astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma. The Skylab 3 CSM later docked with the Skylab space station cluster in Earth orbit. In addition to the CSM and its launch escape system, the Skylab 3 space vehicle consisted of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-1VB) stage. (The Skylab 1/Saturn V space vehicle with the space station payload was launched from Pad A on May 14, 1973). Photo credit: NASA

The Skylab Airlock Module

NASA Technical Reports Server (NTRS)

1968-01-01

This illustration is a cutaway view of the external arrangement of the Airlock Module (AM). The aft end of the Docking Adapter mated to the AM, and served as the environmental, electrical, and communications control center. The docking adapter also contained the port through which the astronauts exited to perform extravehicular activity. The AM contained a turnel section through which Skylab crewmen could move between the workshop and the forward end of the airlock. It was encircled, for part of its length, at its aft end by the fixed Airlock Shroud (FAS), that had the same diameter as the workshop (22 feet) and was attached to the workshop's forward end. High pressure containers for oxygen and nitrogen providing Skylab's atmosphere, were mounted in the annular space between the outside of the tunnel and the inside of the shroud. The forward end of the FAS was the base on which the tubular structure supporting the solar observatory was mounted. Many of the supplies, and most of the control systems for Skylab were located in the AM; this module could well be the 'utility center' of the Skylab cluster. McDonnell Douglas fabricated the module with close Marshall Space Flight Center's involvement in design, development, and test activities.

Skylab

NASA Image and Video Library

1968-01-01

This illustration is a cutaway view of the internal arrangement of the Airlock Module (AM). The aft end of the Docking Adapter mated to the AM, and served as the environmental, electrical, and communications control center. The docking adapter also contained the port through which the astronauts exited to perform extravehicular activity. The AM contained a turnel section through which Skylab crewmen could move between the workshop and the forward end of the airlock. It was encircled, for part of its length, at its aft end by the fixed Airlock Shroud (FAS), that had the same diameter as the workshop (22 feet) and was attached to the workshop's forward end. High pressure containers for oxygen and nitrogen providing Skylab's atmosphere, were mounted in the annular space between the outside of the tunnel and the inside of the shroud. The forward end of the FAS was the base on which the tubular structure supporting the solar observatory was mounted. Many of the supplies, and most of the control systems for Skylab were located in the AM; this module could well be the "utility center" of the Skylab cluster. McDonnell Douglas fabricated the module with close Marshall Space Flight Center's involvement in design, development, and test activities.

Skylab

NASA Image and Video Library

1968-01-01

This illustration is a cutaway view of the external arrangement of the Airlock Module (AM). The aft end of the Docking Adapter mated to the AM, and served as the environmental, electrical, and communications control center. The docking adapter also contained the port through which the astronauts exited to perform extravehicular activity. The AM contained a turnel section through which Skylab crewmen could move between the workshop and the forward end of the airlock. It was encircled, for part of its length, at its aft end by the fixed Airlock Shroud (FAS), that had the same diameter as the workshop (22 feet) and was attached to the workshop's forward end. High pressure containers for oxygen and nitrogen providing Skylab's atmosphere, were mounted in the annular space between the outside of the tunnel and the inside of the shroud. The forward end of the FAS was the base on which the tubular structure supporting the solar observatory was mounted. Many of the supplies, and most of the control systems for Skylab were located in the AM; this module could well be the "utility center" of the Skylab cluster. McDonnell Douglas fabricated the module with close Marshall Space Flight Center's involvement in design, development, and test activities.

The Skylab Airlock Module

NASA Technical Reports Server (NTRS)

1968-01-01

This illustration is a cutaway view of the internal arrangement of the Airlock Module (AM). The aft end of the Docking Adapter mated to the AM, and served as the environmental, electrical, and communications control center. The docking adapter also contained the port through which the astronauts exited to perform extravehicular activity. The AM contained a turnel section through which Skylab crewmen could move between the workshop and the forward end of the airlock. It was encircled, for part of its length, at its aft end by the fixed Airlock Shroud (FAS), that had the same diameter as the workshop (22 feet) and was attached to the workshop's forward end. High pressure containers for oxygen and nitrogen providing Skylab's atmosphere, were mounted in the annular space between the outside of the tunnel and the inside of the shroud. The forward end of the FAS was the base on which the tubular structure supporting the solar observatory was mounted. Many of the supplies, and most of the control systems for Skylab were located in the AM; this module could well be the 'utility center' of the Skylab cluster. McDonnell Douglas fabricated the module with close Marshall Space Flight Center's involvement in design, development, and test activities.

San Francisco and Bay Area, CA, USA

NASA Image and Video Library

1973-06-22

SL2-03-118 (June 1973) --- An infrared photograph of the San Francisco Bay, California area, taken from the Skylab 1/2 space station in Earth orbit. THE PICTURE SHOULD BE HELD WITH THE CLOUDS AND PACIFIC OCEAN ON THE LEFT. This photograph was taken by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the space station. Type 2443 film was used. Note the thickly populated and highly developed area around the bay. Among the cities visible in this photograph are San Francisco, Oakland, Berkeley and San Jose. This view extends eastward to show a portion of the San Joaquin Valley. The S190-A experiment is part of the Skylab Earth Resources Experiment Package (EREP). Photo credit: NASA

View of the Skylab space station cluster photographed against black sky

NASA Image and Video Library

1973-07-28

SL3-114-1682 (28 July 1973) --- A close-up view of the Skylab Space Station photographed against an Earth background from the Skylab 3 Command and Service Modules (CSM) during station-keeping maneuvers prior to docking. Aboard the Command Module (CM) were astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma, who remained with the Skylab Space Station in Earth orbit for 59 days. This picture was taken with a hand-held 70mm Hasselblad camera using a 100mm lens and SO-368 medium speed Ektachrome film. Photo credit: NASA

Skylab: The Second Manned Mission. A Scientific Harvest

NASA Technical Reports Server (NTRS)

1974-01-01

This black and white video presentation covers the Skylab launch activities and docking with unmanned SL-1 workshop. Included are observations of student experiments (the Minchmog minnows and Arabella, the spider), observations of student experiments, exercise routines, and the enabling of the Earth Resources Experiments Package. Also shown is planet Earth documentation, manned operation of the Apollo Telescope Mount for observations of the Sun and beyond, outside EVA activity, testing of the Astronaut Maneuvering Unit, experiments to explore industrial uses of space, and the Skylab living routine.

SL2-06-102

NASA Image and Video Library

1973-06-01

SL2-06-102 (June 1973) --- A black and white photograph of the San Francisco Bay California area, taken from the Skylab 1-2 space station cluster in Earth orbit. THE PICTURE SHOULD BE HELD WITH THE CLOUDS AND PACIFIC OCEAN ON THE LEFT. This photograph was taken by one of six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the space station. Note the thickly populated and highly developed area around the Bay. Among the cities visible in this photograph are San Francisco, Oakland, Berkeley and San Jose. This view extends eastward to show a portion of the San Joaquin Valley. The S190-A experiment is part of the Skylab Earth Resources Experiments Package (EREP). Type SO-022 film was used. This station covered the spectral region from 0.5 to 0.6 micrometers. Photo credit: NASA

SL2-05-102

NASA Image and Video Library

1973-06-01

SL2-05-102 (June 1973) --- A black and white photograph of the San Francisco Bay California area, taken from the Skylab 1-2 space station cluster in Earth orbit. THE PICTURE SHOULD BE HELD WITH THE CLOUDS AND PACIFIC OCEAN ON THE LEFT. This photograph was taken by one of six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the space station. Note the thickly populated and highly developed area around the Bay. Among the cities visible in this photograph are San Francisco, Oakland, Berkeley and San Jose. This view extends eastward to show a portion of the San Joaquin Valley. The S190-A experiment is part of the Skylab Earth Resources Experiments Package (EREP). Type SO-022 film was used. This station covered the spectral region from 0.6 to .07 micrometers. Photo credit: NASA

Lake Powell, Colorado River, Utah and Grand Canyon, Arizona

NASA Image and Video Library

1973-06-22

SL2-04-018 (June 1973) --- A vertical view of the Arizona-Utah border area showing the Colorado River and Grand Canyon photographed from the Skylab 1/2 space station in Earth orbit. This picture was taken by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the space station. Type S0-356 film was used. The row of white clouds extend north-south over the dark colored Kaibab Plateau. The junction of the Colorado and Little Colorado rivers is in the southwest corner of the picture. The body of water is Lake Powell on the Colorado River upstream from the Grand Canyon. The lone peak at the eastern edge of the photograph south of Colorado River is the 10,416-foot Navajo Mountain. The S190-A experiment is part of the Skylab Earth Resources Experiments Package(EREP). Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment Motor Sensory Performance, proposed by Kathy L. Jackson of Houston, Texas. Her proposal was a very simple but effective test to measure the potential degradation of man's motor-sensory skills while weightless. Without knowing whether or not man can retain a high level of competency in the performance of various tasks after long exposure to weightlessness, this capability could not be fully known. Skylab, with its long-duration missions, provided an ideal testing situation. The experiment Kathy Jackson proposed was similar in application to the tasks involved in docking one spacecraft to another using manual control. It required one of the greatest tests of the motor-sensory capabilities of man. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Motor Sensory Performance - Skylab Student Experiment ED-41

NASA Technical Reports Server (NTRS)

1973-01-01

This chart describes the Skylab student experiment Motor Sensory Performance, proposed by Kathy L. Jackson of Houston, Texas. Her proposal was a very simple but effective test to measure the potential degradation of man's motor-sensory skills while weightless. Without knowing whether or not man can retain a high level of competency in the performance of various tasks after long exposure to weightlessness, this capability could not be fully known. Skylab, with its long-duration missions, provided an ideal testing situation. The experiment Kathy Jackson proposed was similar in application to the tasks involved in docking one spacecraft to another using manual control. It required one of the greatest tests of the motor-sensory capabilities of man. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

SKYLAB 1 SOLAR CELL ARRAY INSTALLATION IN VAB

NASA Technical Reports Server (NTRS)

1972-01-01

One of Skylab 1's solar cell arrays installed on the orbital space station in High Bay 2 of the Vehicle Assembly Building today. Skylab 2 in High Bay 1 in visible in the background. Each of the two solar cell arrays on the space station that will be deployed in orbit, is designed to provide 10,500 watts of power at 55 degrees centigrade while in the sunlight portion of each orbit. All power needed to operate the station and the Apollo Telescope mount will be taken from the arrays. The remainder of the power generated will be diverted to battery chargers which will keep the batteries at full charge and ready for use while the orbiting spacecraft cluster is in the Earth's shadow. Each array will have almost 1,177 square feet of surface area to turn sunlight into electrical power. Skylab 1 is schedule for launch April 30, 1973 and Skylab 2, carrying the astronauts Conrad, Kerwin and Weitz to dock with the space station and enter it to live and work for 28 days, will be launched a day later.

Skylab

NASA Image and Video Library

1973-05-01

After its launch on May 14, 1973, it was immediately known that there were some major problems with Skylab. The large, delicate, meteoroid shield on the outside of the workshop was ripped off by the vibration of the launch. Its tearing off caused serious damage to the two wings of solar cells that were to supply most of the electric power to the workshop. Once in orbit, the news worsened. The loss of the big shade exposed the metal skin of the workshop to the sun. Internal temperatures soared to 126 degrees F. This heat not only threatened its habitation by astronauts, but if prolonged, would cause serious damage to instruments and film. After twice delaying the launch of the first astronaut crew, engineers worked frantically to develop solutions to these problems and salvage the Skylab. After designing a protective solar sail to cover the workshop, crews needed to practice using the specially designed tools and materials to facilitate the repair procedure. Marshall Space Flight Center's Neutral Buoyancy Simulator (NBS), was used to practice these maneuvers. Pictured here are the astronauts in the NBS deploying the protecticve solar sail. On may 25, 1973, an Apollo command and service module was launched and later docked with Skylab. The next day, astronauts Conrad and Kerwin were able to complete the needed repairs to Skylab, salvaging the entire program.

Impingement effect of service module reaction control system engine plumes. Results of service module reaction control system plume model force field application to an inflight Skylab mission proximity operation situation with the inflight Skylab response

NASA Technical Reports Server (NTRS)

Lobb, J. D., Jr.

1978-01-01

Plume impingement effects of the service module reaction control system thruster firings were studied to determine if previous flight experience would support the current plume impingement model for the orbiter reaction control system engines. The orbiter reaction control system is used for rotational and translational maneuvers such as those required during rendezvous, braking, docking, and station keeping. Therefore, an understanding of the characteristics and effects of the plume force fields generated by the reaction control system thruster firings were examined to develop the procedures for orbiter/payload proximity operations.

View of Minneapolis-St.Paul, Minnesota area

NASA Image and Video Library

1973-08-30

SL3-28-009 (July-September 1973) --- A near vertical view of the Minneapolis-St. Paul, Minnesota area, as photographed from Earth orbit by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the Skylab space station. A 150mm lens, with SO-356 high definition Ektachrome film, was used to take this picture. The Mississippi River flows southeasterly through this large metropolitan area. Minneapolis is on the west bank of the Mississippi. The Minnesota River makes a large bend at the southern edge of the picture then flows northeasterly to empty into the Mississippi at Minneapolis-St. Paul. The St. Croix River, which serves as a portion of the boundary between Minnesota and Wisconsin, flows into the Mississippi downstream from the twin cities. A long, nearly straight, stretch of Interstate 35 leads southward from Minneapolis-St. Paul. Interstate 94 parallels the Mississippi toward the northwest. The highway and road network in the area is clearly visible. Note the numerous small lakes in the photograph. This view includes the smaller cities of Hastings, Faribault, Owatonna, Mankato, St. Peter, New Ulm and St. Cloud. The S190-A experiment is part of the Skylab Earth Resources Experiments Package. Photo credit: NASA

SL2-16-281

NASA Image and Video Library

1973-06-01

SL2-16-281 (June 1973) --- A vertical view of the Orlando and central Florida area photographed from the Skylab space station in Earth orbit. (The picture should be held with the heaviest cloud cover at the bottom.) The extensive road and highway network in the area is clearly visible. The Lakeland and Winter Haven area is near the center of the picture. Interstate 4 extends southwesterly out of Orlando through the center of the picture. The urban growth caused by the opening of the Disney World amusement complex is clearly evident. The giant recreational facility is just southwest of Orlando. This picture was taken by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the space station. Type SO-356 film was used. Photo credit: NASA

Eastern Iowa, Northwestern Illinois

NASA Image and Video Library

1973-06-22

SL2-10-250 (May-June 1973) --- A vertical view of eastern Iowa and northwestern Illinois, as photographed from Skylab space station in Earth orbit. Davenport, Burlington and Muscatine, Iowa; and Rock Island and Moline, Illinois can be delineated on opposite sides of the Mississippi River. The Iowa River and tributaries of it can also be delineated. This photograph was taken with one of six lenses of the Itek-furnished Multispectral Photographic Facility Experiment S190-A mounted in the Multiple Docking Adapter (MDA) of the space station. A six-inch lens, using 70mm medium speed Ektachrome (SO-356) film, was used. Agencies participating with NASA on the EREP project are the Departments of Agriculture, Commerce and Interior; the Environmental Protection Agency and the Corps of Engineers. All EREP photography is available to the public through the Department of Interior's Earth Resources Observations Systems Data Center, Sioux Falls, South Dakota, 57198. Photo credit: NASA

Manual control aspects of orbital flight

NASA Technical Reports Server (NTRS)

Brody, Adam R.

1990-01-01

Studies of spacecraft rendezvous and docking operations began in the Gemini program in preparation for the two dockings required to send a crew to the moon and return them safely to Earth. However, the goal of getting to the moon before the end of the decade was of greater concern than mission optimization so little or no time or money was expended in researching human factors implications of operational aspects such as braking gates or control modes. Also, with sixteen operational dockings over a six year period (12 Apollo, 3 Skylab, and 1 ASTP) in the United States space program, economies of scale were not yet available to justify extensive research into decreasing the time or fuel necessary for a successful docking. With an operational space station era approaching in which orbital maneuvering vehicle (OMV), orbital transfer vehicle (OTV), shuttle orbiter, and other traffic will play a major role, a concerted research effort now could help avoid many potential problems later in addition to increasing safety, fuel economy, and productivity. A knowledge of manual control capabilities associated with piloted spaceflight could help save a life if the operational flight envelope can be safely enlarged to include faster dockings that currently envisioned. For example, current and future research is designed to acquire the appropriate information.

SL3-34-336

NASA Image and Video Library

1973-07-01

SL3-34-336 (July-September 1973) --- A vertical view of a portion of northern California near the Pacific coast as photographed from Earth orbit by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the Skylab space station. A cloud deck covers the Pacific Ocean. Most of Cape Mendocino is clear of clouds and extends into the Pacific as the westernmost part of California. The sinuous pattern of the Bel River (in center) flows northward into the ocean and is characteristic of the rivers that drain the coastal ranges. This area is immediately southeast of Eureka. During Skylab 3 extensive forest fires occurred near Briceland and the smoke rising from the fires is clearly visible next to the cloud bank. Redwood and fir forests are sources of lumber in this region; and a variety of clear cut (timbering) patterns appear as light against the dark forest. The patterns appear to be related to the topography. Analysis of this photograph will aid Dr. P.G. Langley, Earth Satellite Corporation, in developing methods for forest inventory using space photography. Federal agencies participating with NASA on the EREP project are the Departments of Agriculture, Commerce, Interior, the Environmental Protection Agency and the Corps of Engineers. All EREP photography is available to the public through the Department of Interior?s Earth Resources Observations Systems Data Center, Sioux Falls, South Dakota, 57198. Photo credit: NASA

STS-71 astronauts training in Russia

NASA Image and Video Library

1994-09-20

S94-45647 (20 Sept 1994) --- Astronaut's Norman E. Thagard and Bonnie J. Dunbar by the Mir Space Station simulator at the Gagarin Cosmonaut Training Center (Star City), near Moscow, Russia. In March 1995, astronaut Thagard is scheduled to be launched in a Russian Soyuz spacecraft with two cosmonauts to begin a three-month tour of duty on the Russian Mir Space Station. Thagard, along with his back-up, astronaut Dunbar, has been training in Russia since February 1994. During his stay on Mir, he will conduct a variety of life sciences experiments that will provide U.S. investigators with the first long-duration exposure data since Skylab in the late 1970's. Thagard's mission will end in late May or early June when the Space Shuttle Atlantis, carrying the newly installed docking mechanism, docks with Mir Space Station for the first United States - Russian docking operation since Apollo-Soyuz in 1975. The Orbiter will remain attached to Mir for five days of joint scientific operations before returning home with Thagard and his Russian crew mates and leaving behind two cosmonauts on Mir.

STS-71 astronauts training in Russia

NASA Image and Video Library

1994-09-20

S94-45643 (20 Sept 1994) --- Astronaut Norman E. Thagard in a cosmonaut space suit in the Training Simulator Facility at the Gagarin Cosmonaut Training Center (Star City), near Moscow, Russia. In March 1995, astronaut Thagard is scheduled to be launched in a Russian Soyuz spacecraft with two cosmonauts to begin a three-month tour of duty on the Russian Mir Space Station. Thagard, along with his back-up, astronaut Bonnie J. Dunbar, has been training in Russia since February 1994. During his stay on Mir, he will conduct a variety of life sciences experiments that will provide U.S. investigators with the first long-duration exposure data since Skylab in the late 1970's. Thagard's mission will end in July when the Space Shuttle Atlantis, carrying the newly installed docking mechanism, docks with Mir Space Station for the first United States - Russian docking operation since Apollo-Soyuz in 1975. The Orbiter will remain attached to Mir for five days of joint scientific operations before returning home with Thagard and his Russian crew mates and leaving behind two cosmonauts on Mir.

Construction in space - Toward a fresh definition of the man/machine relation

NASA Technical Reports Server (NTRS)

Watters, H. H.; Stokes, J. W.

1979-01-01

The EVA (extravehicular activity) project forming part of the space construction process is reviewed. The manual EVA constuction, demonstrated by the crew of Skylab 3 by assembling a modest space structure in the form of the twin-pole sunshade, is considered, indicating that the experiment dispelled many doubts about man's ability to execute routine and contingency EVA operations. Tests demonstrating the feasibility of remote teleoperator rendezvous, station keeping, and docking operations, using hand controllers for direct input and television for feedback, are noted. Future plans for designing space construction machines are mentioned.

Performance of a capillary propellant management device with hydrazine

NASA Technical Reports Server (NTRS)

Tegart, J. R.

1979-01-01

The propellant management device that was successfully used in the Viking Orbiter spacecraft was selected for the main propulsion system of the Teleoperator Retrieval System (TRS). Due to differences in the missions and different propellants, the operation of this sheet metal vane device required reverification for the TRS application. An analytical investigation was performed considering the adverse acceleration environment and the high contract angle of the hydrazine propellant. Drop tower tests demonstrated that the device would provide propellant acquisition while the TRS was docked with Skylab, but its operation would have to be supplemented through propellant settling when free-flying.

Multiple grid arrangement improves ligand docking with unknown binding sites: Application to the inverse docking problem.

PubMed

Ban, Tomohiro; Ohue, Masahito; Akiyama, Yutaka

2018-04-01

The identification of comprehensive drug-target interactions is important in drug discovery. Although numerous computational methods have been developed over the years, a gold standard technique has not been established. Computational ligand docking and structure-based drug design allow researchers to predict the binding affinity between a compound and a target protein, and thus, they are often used to virtually screen compound libraries. In addition, docking techniques have also been applied to the virtual screening of target proteins (inverse docking) to predict target proteins of a drug candidate. Nevertheless, a more accurate docking method is currently required. In this study, we proposed a method in which a predicted ligand-binding site is covered by multiple grids, termed multiple grid arrangement. Notably, multiple grid arrangement facilitates the conformational search for a grid-based ligand docking software and can be applied to the state-of-the-art commercial docking software Glide (Schrödinger, LLC). We validated the proposed method by re-docking with the Astex diverse benchmark dataset and blind binding site situations, which improved the correct prediction rate of the top scoring docking pose from 27.1% to 34.1%; however, only a slight improvement in target prediction accuracy was observed with inverse docking scenarios. These findings highlight the limitations and challenges of current scoring functions and the need for more accurate docking methods. The proposed multiple grid arrangement method was implemented in Glide by modifying a cross-docking script for Glide, xglide.py. The script of our method is freely available online at http://www.bi.cs.titech.ac.jp/mga_glide/. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Project EGRESS: Earthbound Guaranteed Reentry from Space Station. the Design of an Assured Crew Recovery Vehicle for the Space Station

NASA Technical Reports Server (NTRS)

1990-01-01

Unlike previously designed space-based working environments, the shuttle orbiter servicing the space station will not remain docked the entire time the station is occupied. While an Apollo capsule was permanently available on Skylab, plans for Space Station Freedom call for a shuttle orbiter to be docked at the space station for no more than two weeks four times each year. Consideration of crew safety inspired the design of an Assured Crew Recovery Vehicle (ACRV). A conceptual design of an ACRV was developed. The system allows the escape of one or more crew members from Space Station Freedom in case of emergency. The design of the vehicle addresses propulsion, orbital operations, reentry, landing and recovery, power and communication, and life support. In light of recent modifications in space station design, Project EGRESS (Earthbound Guaranteed ReEntry from Space Station) pays particular attention to its impact on space station operations, interfaces and docking facilities, and maintenance needs. A water-landing medium-lift vehicle was found to best satisfy project goals of simplicity and cost efficiency without sacrificing safety and reliability requirements. One or more seriously injured crew members could be returned to an earth-based health facility with minimal pilot involvement. Since the craft is capable of returning up to five crew members, two such permanently docked vehicles would allow a full evacuation of the space station. The craft could be constructed entirely with available 1990 technology, and launched aboard a shuttle orbiter.

A cross docking pipeline for improving pose prediction and virtual screening performance

NASA Astrophysics Data System (ADS)

Kumar, Ashutosh; Zhang, Kam Y. J.

2018-01-01

Pose prediction and virtual screening performance of a molecular docking method depend on the choice of protein structures used for docking. Multiple structures for a target protein are often used to take into account the receptor flexibility and problems associated with a single receptor structure. However, the use of multiple receptor structures is computationally expensive when docking a large library of small molecules. Here, we propose a new cross-docking pipeline suitable to dock a large library of molecules while taking advantage of multiple target protein structures. Our method involves the selection of a suitable receptor for each ligand in a screening library utilizing ligand 3D shape similarity with crystallographic ligands. We have prospectively evaluated our method in D3R Grand Challenge 2 and demonstrated that our cross-docking pipeline can achieve similar or better performance than using either single or multiple-receptor structures. Moreover, our method displayed not only decent pose prediction performance but also better virtual screening performance over several other methods.

Intra-Extra Vehicular Activity Apollo Spacesuits

NASA Technical Reports Server (NTRS)

Thomas, Kenneth S.

2016-01-01

Kenneth Thomas will discuss the Apollo Intra-Extra Vehicular Activity (IEVA) spacesuits, which supported launch and reentry and extra-vehicular activity. This program was NASA's first attempt to develop a new suit design from requirements and concepts. Mr. Thomas will chronicle the challenges, developments, struggles, and solutions that culminated in the system that allowed the first human exploration of the Moon and deep space (outside low-Earth orbit). Apollo pressure suit designs allowed the heroic repair of the Skylab space station and supported the first U.S. and Russian spacecraft docking during the Apollo Soyuz Test Project. Mr. Thomas will also discuss the IEVA suits' successes and challenges associated with the IEVA developments of the 1960s.

CSM docked DAP/orbital assembly bending interaction-axial case

NASA Technical Reports Server (NTRS)

Turnbull, J. F.; Jones, J. E.

1972-01-01

A digital autopilot which can provide attitude control for the entire Skylab orbital assembly using the service module reaction control jets is described. An important consideration is the potential interaction of the control system with the bending modes of the orbital assembly. Two aspects of this potential interaction were considered. The first was the possibility that bending induced rotations feeding back through the attitude sensor into the control system could produce an instability or self-sustained oscillation. The second was whether the jet activity commanded by the control system could produce excessive loads at any of the critical load points of the orbital assembly. Both aspects were studied by using analytic techniques and by running simulations on the all-digital simulator.

SL3-34-056

NASA Image and Video Library

1973-07-01

SL3-34-056 (July-September 1973) --- A near vertical view of an 8,000 square-mile area of the Grand Erg Oriental in east central Algeria as photographed from Earth orbit by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the Skylab space station. The Grand Erg contains vast areas of sand dunes and sand plains. This photograph illustrates the variety of surface features that are characteristic of the Sahara Desert. The dark areas are relatively sand free, and may contain rock outcrops along which travel is considerably easier. Sand dunes are abundant in this picture, and their size, shape, location and pattern are due to the underlying topography and direction of the prevailing winds. Scientists interested in study of dune fields will be able to use this photograph for detailed analysis of the dune features, especially their characteristics adjacent to the sand-free areas. Federal agencies participating with NASA on the EREP project are the Departments of Agriculture, Commerce, Interior, the Environmental Protection Agency and the Corps of Engineers. All EREP photography is available to the public through the Department of Interior?s Earth Resources Observations Systems Data Center, Sioux Falls, South Dakota, 57198. Photo credit: NASA

S4MPLE--Sampler for Multiple Protein-Ligand Entities: Methodology and Rigid-Site Docking Benchmarking.

PubMed

Hoffer, Laurent; Chira, Camelia; Marcou, Gilles; Varnek, Alexandre; Horvath, Dragos

2015-05-19

This paper describes the development of the unified conformational sampling and docking tool called Sampler for Multiple Protein-Ligand Entities (S4MPLE). The main novelty in S4MPLE is the unified dealing with intra- and intermolecular degrees of freedom (DoF). While classically programs are either designed for folding or docking, S4MPLE transcends this artificial specialization. It supports folding, docking of a flexible ligand into a flexible site and simultaneous docking of several ligands. The trick behind it is the formal assimilation of inter-molecular to intra-molecular DoF associated to putative inter-molecular contact axes. This is implemented within the genetic operators powering a Lamarckian Genetic Algorithm (GA). Further novelty includes differentiable interaction fingerprints to control population diversity, and fitting a simple continuum solvent model and favorable contact bonus terms to the AMBER/GAFF force field. Novel applications-docking of fragment-like compounds, simultaneous docking of multiple ligands, including free crystallographic waters-were published elsewhere. This paper discusses: (a) methodology, (b) set-up of the force field energy functions and (c) their validation in classical redocking tests. More than 80% success in redocking was achieved (RMSD of top-ranked pose < 2.0 Å).

Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations.

PubMed

Sgobba, Miriam; Caporuscio, Fabiana; Anighoro, Andrew; Portioli, Corinne; Rastelli, Giulio

2012-12-01

In the last decades, molecular docking has emerged as an increasingly useful tool in the modern drug discovery process, but it still needs to overcome many hurdles and limitations such as how to account for protein flexibility and poor scoring function performance. For this reason, it has been recognized that in many cases docking results need to be post-processed to achieve a significant agreement with experimental activities. In this study, we have evaluated the performance of MM-PBSA and MM-GBSA scoring functions, implemented in our post-docking procedure BEAR, in rescoring docking solutions. For the first time, the performance of this post-docking procedure has been evaluated on six different biological targets (namely estrogen receptor, thymidine kinase, factor Xa, adenosine deaminase, aldose reductase, and enoyl ACP reductase) by using i) both a single and a multiple protein conformation approach, and ii) two different software, namely AutoDock and LibDock. The assessment has been based on two of the most important criteria for the evaluation of docking methods, i.e., the ability of known ligands to enrich the top positions of a ranked database with respect to molecular decoys, and the consistency of the docking poses with crystallographic binding modes. We found that, in many cases, MM-PBSA and MM-GBSA are able to yield higher enrichment factors compared to those obtained with the docking scoring functions alone. However, for only a minority of the cases, the enrichment factors obtained by using multiple protein conformations were higher than those obtained by using only one protein conformation. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Surflex-Dock: Docking benchmarks and real-world application

NASA Astrophysics Data System (ADS)

Spitzer, Russell; Jain, Ajay N.

2012-06-01

Benchmarks for molecular docking have historically focused on re-docking the cognate ligand of a well-determined protein-ligand complex to measure geometric pose prediction accuracy, and measurement of virtual screening performance has been focused on increasingly large and diverse sets of target protein structures, cognate ligands, and various types of decoy sets. Here, pose prediction is reported on the Astex Diverse set of 85 protein ligand complexes, and virtual screening performance is reported on the DUD set of 40 protein targets. In both cases, prepared structures of targets and ligands were provided by symposium organizers. The re-prepared data sets yielded results not significantly different than previous reports of Surflex-Dock on the two benchmarks. Minor changes to protein coordinates resulting from complex pre-optimization had large effects on observed performance, highlighting the limitations of cognate ligand re-docking for pose prediction assessment. Docking protocols developed for cross-docking, which address protein flexibility and produce discrete families of predicted poses, produced substantially better performance for pose prediction. Performance on virtual screening performance was shown to benefit by employing and combining multiple screening methods: docking, 2D molecular similarity, and 3D molecular similarity. In addition, use of multiple protein conformations significantly improved screening enrichment.

Skylab

NASA Image and Video Library

1969-07-01

This is an aerial view of the deep-sea research submarine "Ben Franklin" at dock. Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep-ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life, and also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effects of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

Dummy left behind by Skylab 3 crew for the Skylab 4 crew

NASA Image and Video Library

1973-08-16

SL3-113-1586 (July-September 1973) --- This photograph is an illustration of the humorous side of the Skylab 3 crew. This dummy was left behind in the Skylab space station by the Skylab 3 crew to be found by the Skylab 4 crew. The dummy is dressed in a flight suit and placed in the Lower Body Negative Pressure Device. The name tag indicates that it represents Gerald P. Carr, Skylab 4 commander, in the background is a partial view of the dummy for William R. Pogue, Skylab 4 pilot, propped upon the bicycle ergometer. The dummy representing Edward G. Gibson, Skylab science pilot, was left in the waste compartment. Astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma were the Skylab 3 crewmen. Photo credit: NASA

Dummy left behind by Skylab 3 crew for the Skylab 4 crew

NASA Image and Video Library

1973-08-16

SL3-113-1587 (July-September 1973) --- This photograph is an illustration of the humorous side of the Skylab 3 crew. This dummy was left behind in the Skylab space station by the Skylab 3 crew to be found by the Skylab 4 crew. The dummy is dressed in a flight suit and propped upon the bicycle ergometer. The name tag indicated that it represents William R. Pogue, Skylab pilot. The dummy for Gerald P. Carr, Skylab 4 commander, was placed in the Lower Body Negative Pressure Device. The dummy representing Edward G. Gibson was left in the waste compartment. Astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma were the Skylab 3 crewmen. Gibson is the Skylab 4 science pilot. Photo credit: NASA

Docking of small molecules to farnesoid X receptors using AutoDock Vina with the Convex-PL potential: lessons learned from D3R Grand Challenge 2

NASA Astrophysics Data System (ADS)

Kadukova, Maria; Grudinin, Sergei

2018-01-01

The 2016 D3R Grand Challenge 2 provided an opportunity to test multiple protein-ligand docking protocols on a set of ligands bound to farnesoid X receptor that has many available experimental structures. We participated in the Stage 1 of the Challenge devoted to the docking pose predictions, with the mean RMSD value of our submission poses of 2.9 Å. Here we present a thorough analysis of our docking predictions made with AutoDock Vina and the Convex-PL rescoring potential by reproducing our submission protocol and running a series of additional molecular docking experiments. We conclude that a correct receptor structure, or more precisely, the structure of the binding pocket, plays the crucial role in the success of our docking studies. We have also noticed the important role of a local ligand geometry, which seems to be not well discussed in literature. We succeed to improve our results up to the mean RMSD value of 2.15-2.33 Å dependent on the models of the ligands, if docking these to all available homologous receptors. Overall, for docking of ligands of diverse chemical series we suggest to perform docking of each of the ligands to a set of multiple receptors that are homologous to the target.

Dummy left behind by Skylab 3 crew for the Skylab 4 crew

NASA Technical Reports Server (NTRS)

1973-01-01

This photograph is an illustration of the humorous side of the Skylab 3 crew. This dummy was left behind in the Skylab space station by the Skylab 3 crew to be found by the Skylab 4 crew. The dummy is dressed in a flight suit and placed in the Lower Body Negative Pressure Device. The name tag indicates that it represents Gerald P. Carr, Skylab 4 commander. In the background is a partial view of the dummy for William R. Pogue, Skylab 4 pilot, propped upon the bicycle ergometer (1586); This dummy is dressed in a flight suit and propped upon the bicycle ergometer. The name tag indicates that it represents William R. Pogue, Skylab 4 pilot (1587).

Skylab 2 astronauts eat space food in wardroom of Skylab trainer

NASA Technical Reports Server (NTRS)

1973-01-01

The three members of the prime crew of the first manned Skylab mission dine on specially prepared Skylab space food in the wardromm of the crew quarters of the Skylab Orbital Workshop (OWS) trainer during Skylab training at the Johnson Space Center. They are, left to right, Scientist-Astronaut Joseph P. Kerwin, science pilot; Astronaut Paul J. Weitz, pilot; and Astronaut Charles Conrad Jr., commander.

Skylab reactivation mission report

NASA Technical Reports Server (NTRS)

Chubb, W. B.

1980-01-01

On July 11, 1979, Skylab impacted the Earth's surface. The debris dispersion area stretched from the South Eastern Indian Ocean across a sparsely populated section of Western Australia. The events leading to the reentry of Skylab are discussed and a final assessment of the Skylab debris impact footprint is presented. Also included are detailed evaluations of the various Skylab systems that were reactivated when control of Skylab was regained in mid-1978 after having been powered down since February 4, 1974.

Radiological protection and medical dosimetry for the Skylab crewmen

NASA Technical Reports Server (NTRS)

Bailey, J. V.; Hoffman, R. A.; English, R. A.

1977-01-01

Dosimetry results for Skylab crewmembers show that the Skylab 4 crewmen received the highest dose equivalents but remained well within the established limits for Skylab missions below the threshold of significant clinical effects. These dose equivalents apply specificially to long term effects such as general life shortening, increased neoplasm incidence, and cataract production. A Skylab crewman could fly a mission comparable to one 84-day Skylab 4 mission per year for 50 years before exceeding these career limits.

JADOPPT: java based AutoDock preparing and processing tool.

PubMed

García-Pérez, Carlos; Peláez, Rafael; Therón, Roberto; Luis López-Pérez, José

2017-02-15

AutoDock is a very popular software package for docking and virtual screening. However, currently it is hard work to visualize more than one result from the virtual screening at a time. To overcome this limitation we have designed JADOPPT, a tool for automatically preparing and processing multiple ligand-protein docked poses obtained from AutoDock. It allows the simultaneous visual assessment and comparison of multiple poses through clustering methods. Moreover, it permits the representation of reference ligands with known binding modes, binding site residues, highly scoring regions for the ligand, and the calculated binding energy of the best ranked results. JADOPPT, supplementary material (Case Studies 1 and 2) and video tutorials are available at http://visualanalytics.land/cgarcia/JADOPPT.html. carlosgarcia@usal.es or pelaez@usal.es. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Multiple ligand simultaneous docking: orchestrated dancing of ligands in binding sites of protein.

PubMed

Li, Huameng; Li, Chenglong

2010-07-30

Present docking methodologies simulate only one single ligand at a time during docking process. In reality, the molecular recognition process always involves multiple molecular species. Typical protein-ligand interactions are, for example, substrate and cofactor in catalytic cycle; metal ion coordination together with ligand(s); and ligand binding with water molecules. To simulate the real molecular binding processes, we propose a novel multiple ligand simultaneous docking (MLSD) strategy, which can deal with all the above processes, vastly improving docking sampling and binding free energy scoring. The work also compares two search strategies: Lamarckian genetic algorithm and particle swarm optimization, which have respective advantages depending on the specific systems. The methodology proves robust through systematic testing against several diverse model systems: E. coli purine nucleoside phosphorylase (PNP) complex with two substrates, SHP2NSH2 complex with two peptides and Bcl-xL complex with ABT-737 fragments. In all cases, the final correct docking poses and relative binding free energies were obtained. In PNP case, the simulations also capture the binding intermediates and reveal the binding dynamics during the recognition processes, which are consistent with the proposed enzymatic mechanism. In the other two cases, conventional single-ligand docking fails due to energetic and dynamic coupling among ligands, whereas MLSD results in the correct binding modes. These three cases also represent potential applications in the areas of exploring enzymatic mechanism, interpreting noisy X-ray crystallographic maps, and aiding fragment-based drug design, respectively. 2010 Wiley Periodicals, Inc.

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.

PubMed

Lu, Mingjian; Kinchen, Jason M; Rossman, Kent L; Grimsley, Cynthia; Hall, Matthew; Sondek, John; Hengartner, Michael O; Yajnik, Vijay; Ravichandran, Kodi S

2005-02-22

CDM (CED-5, Dock180, Myoblast city) family members have been recently identified as novel, evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases . They regulate multiple processes, including embryonic development, cell migration, apoptotic-cell engulfment, tumor invasion, and HIV-1 infection, in diverse model systems . However, the mechanism(s) of regulation of CDM proteins has not been well understood. Here, our studies on the prototype member Dock180 reveal a steric-inhibition model for regulating the Dock180 family of GEFs. At basal state, the N-terminal SH3 domain of Dock180 binds to the distant catalytic Docker domain and negatively regulates the function of Dock180. Further studies revealed that the SH3:Docker interaction sterically blocks Rac access to the Docker domain. Interestingly, ELMO binding to the SH3 domain of Dock180 disrupted the SH3:Docker interaction, facilitated Rac access to the Docker domain, and contributed to the GEF activity of the Dock180/ELMO complex. Additional genetic rescue studies in C. elegans suggested that the regulation of the Docker-domain-mediated GEF activity by the SH3 domain and its adjoining region is evolutionarily conserved. This steric-inhibition model may be a general mechanism for regulating multiple SH3-domain-containing Dock180 family members and may have implications for a variety of biological processes.

Skylab 2 Farewell View from the Departing Skylab Command/Service Module

NASA Image and Video Library

1973-06-22

SL2-07-667 (22 June 1973) --- This overhead view of the Skylab Space Station was taken from the Departing Skylab Command/Service Module during the Skylab 2's final fly-around inspection. The single solar panel is quite evident as well as the parasol solar shield, rigged to replace the missing micrometeoroid shield. Both the second solar panel and the micrometeoroid shield were torn away during a mishap in the original Skylab 1 liftoff and orbital insertion. Photo credit: NASA

Skylab 2 Farewell View from the Departing Skylab Command/Service Module

NASA Image and Video Library

1973-06-22

SL2-07-651 (22 June 1973) --- This overhead view of the Skylab Space Station was taken from the Departing Skylab Command/Service Module during the Skylab 2's final fly-around inspection. The single solar panel is quite evident as well as the parasol solar shield, rigged to replace the missing micrometeoroid shield. Both the second solar panel and the micrometeoroid shield were torn away during a mishap in the original Skylab 1 liftoff and orbital insertion. Photo credit: NASA

Skylab

NASA Image and Video Library

1974-01-01

This image of Skylab in orbit was taken as the third crew (Skylab-4) departed the space station after 84 days in the orbiting laboratory. A smiling Skylab seemed to wink good-bye for the job well done.

Skylab (SL)-3 Crew - KSC

NASA Image and Video Library

1973-08-03

S73-31801 (28 July 1973) --- The three crewmen of the second manned Skylab mission (Skylab 3) leave the Manned Spacecraft Operations Building at the Kennedy Space Center on the morning of the Skylab 3 launch. Leading is astronaut Alan L. Bean, commander; followed by scientist-astronaut Owen K. Garriott, science pilot; and astronaut Jack R. Lousma, pilot. They entered the special van which carried them to Pad B at KSC?s Launch Complex 39 where the Skylab 3/Saturn 1B space vehicle awaited them. The Skylab 3 liftoff was at 7:11 a.m. (EDT), Saturday, July 28, 1973. The three astronauts were scheduled to spend 59 days at the Skylab space station in Earth orbit. Photo credit: NASA

Skylab

NASA Image and Video Library

1974-01-01

This photograph was taken as the third crew (Skylab-4) departed the space station. The solar observatory was designed for full exposure to the Sun throughout most of the Skylab mission. Solar energy was transformed into electrical power for operation of all spacecraft systems. The proper operation of these solar arrays was vital to the mission. This Skylab in orbit view was taken by the Skylab-4 crew.

Pulmonary function evaluation during and following Skylab space flights

NASA Technical Reports Server (NTRS)

Sawin, C. F.; Nicogossian, A. E.; Schachter, A. P.; Rummel, J. A.; Michel, E. L.

1974-01-01

Previous experience during the Apollo postflight exercise testing indicated no major changes in pulmonary function. Although pulmonary function has been studied in detail following exposure to hypoxic and hyperoxic environments, few studies have dealt with normoxic environments at reduced total pressure as encountered during the Skylab missions. Forced vital capacity was measured during the preflight and postflight periods of the Skylab 2 mission. Initial in-flight measurements of vital capacity were obtained during the last two weeks of the second manned mission (Skylab 3). Comprehensive pulmonary function screening was accomplished during the Skylab 4 mission. The primary measurements made during Skylab 4 testing included residual volume determination, closing volume, vital capacity, and forced vital capacity and its derivatives. In addition, comprehensive in-flight vital capacity measurements were made during the Skylab 4 mission. Vital capacity was decreased slightly during flight in all Skylab 4 crewmen. No major preflight to postflight changes were observed in the other parameters.

Skylab

NASA Image and Video Library

1970-01-01

Assembling activities of the Skylab cluster are shown in this photograph. The Orbital Workshop (OWS) was lowered for joining to aft skirt and placed over the thrust structure inside the assembly tower. The OWS provided living and working quarters for the Skylab crew and the thruster provided short-term attitude control of the Skylab. The Marshall Space Flight Center had responsibilities for the design and development of the Skylab hardware, and management of experiments.

SKYLAB IV - LAUNCH

NASA Image and Video Library

1973-11-27

S73-37285 (16 Nov. 1973) --- The Skylab 4/Saturn 1B space vehicle is launched from Pad B, Launch Complex 39, Kennedy Space Center, Florida, at 9:01:23 a.m. (EST), Friday, Nov. 16, 1973. Skylab 4 is the third and last of three scheduled manned Skylab missions. Aboard the Skylab 4 Command/Service Module were astronauts Gerald P. Carr, Edward G. Gibson and William R. Pogue. In addition to the CSM and its launch escape system, the Skylab 4 space vehicle consisted of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-IVB) stage. (The Skylab 1/Saturn V unmanned space vehicle with the space station payload was launched from Pad A on May 14, 1973). Photo credit: NASA

SKYLAB IV - LAUNCH

NASA Image and Video Library

1973-11-27

S73-37286 (16 Nov. 1973) --- The Skylab 4/Saturn 1B space vehicle is launched from Pad B, Launch Complex 39, Kennedy Space Center, Florida, at 9:01:23 a.m. (EST), Friday, Nov. 16, 1973. Skylab 4 is the third and last of three scheduled manned Skylab missions. Aboard the Skylab 4 Command/Service Module were astronauts Gerald P. Carr, Edward G. Gibson and William R. Pogue. In addition to the CSM and its launch escape system, the Skylab 4 space vehicle consisted of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-IVB) stage. (The Skylab 1/Saturn V unmanned space vehicle with the space station payload was launched from Pad A on May 14, 1973). Photo credit: NASA

Skylab: A guidebook

NASA Technical Reports Server (NTRS)

Belew, L. F.; Stuhlinger, E.

1973-01-01

A description of the history and development of the Skylab program is presented. Mission objectives, launch preparations, and crew activities and training program are outlined. Skylab design and operation are presented, and research programs on Skylab are described along with ground-based supporting projects.

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment Objects Within Mercury's Orbit, proposed by Daniel C. Bochsler of Silverton, Oregon. This experiment utilized Skylab's White Light Coronagraph telescope to identify any objects orbiting the Sun within the orbit of Mercury. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab

NASA Image and Video Library

1973-06-01

This EREP color infrared photograph of the Uncompahgre Plateau area of Colorado was taken in June of 1973 by the Earth Terrain Camera (Skylab EREP Experiment S190B) of the Skylab's Multi-spectral Photographic Facility during the Skylab-2 mission. Skylab stereoscopic data provided the best identification of vegetation complexes and delineation of vegetation boundaries, particularly in areas where changes in relief were related to changes in vegetation type (a common occurrence in wild-land vegetation communities).

Skylab and the Sun

NASA Technical Reports Server (NTRS)

1973-01-01

Articles pertaining to the solar studies and the Skylab program are presented, with emphasis on the usefulness of the Apollo Telescope Mount (ATM) program. A description of Skylab objectives and key mission events is included along with articles about the sun. Skylab solar studies which are reported include these topics: ATM solar observatory, scientific instruments, crew operations and crew training, and the joint observing program. The Skylab associated solar programs are also reported.

Spaceflight tracking and data network operational reliability computer output for MTBF and availability. Appendix V to CSC-1-395

NASA Technical Reports Server (NTRS)

Seneca, V. I.; Mlynarczyk, R. H.

1974-01-01

Tables of data are provided to show the availability of Skylab data to selected ground stations during the phases of Skylab preflight, Skylab unmanned condition, and Skylab manned condition. The mean time between failure (MTBF) of the same Skylab functions is tabulated for the selected ground stations. All reliability data are based on a 90 percent confidence interval.

ASTRONAUT CHARLES CONRAD, JR. - SKYLAB (SL)-2 - JSC

NASA Image and Video Library

1973-02-27

S73-17859 (January 1973) --- Astronaut Paul J. Weitz, pilot for Skylab 2 (first Skylab manned) mission, looks over off-duty recreational equipment in the crew quarters of the Skylab Orbital Workshop (OWS) trainer during Skylab simulation activity at the Manned Spacecraft Center. The equipment includes such items as tape decks and stereo music equipment, playing cards, darts, etc. The OWS is a component of the Skylab space station cluster which will be launched unmanned aboard a Saturn V in summer of 1973, and will be visited three times by three-man crews over an eight month period. Photo credit: NASA

SKYLAB (SL) - ORBITAL WORKSHOP (OWS) - JSC

NASA Image and Video Library

1973-05-29

S73-26849 (25 May 1973) --- Four flight directors for the Skylab 1 and 2 mission are grouped around the flight director's console in the Mission Operations Control Room in the Mission Control Center at Johnson Space Center during the Skylab 2 Command/Service Module (CSM) "fly around" inspection of the Skylab 1 space station cluster. They are, going counterclockwise from center foreground, Donald R. Puddy (white shirt), Milton Windler, Philip C. Shaffer and M.P. Frank. A view of the Skylab 1 Orbital Workshop seen from the Skylab 2 CSM is visible on the television monitor in the background. Photo credit: NASA

Ligand-biased ensemble receptor docking (LigBEnD): a hybrid ligand/receptor structure-based approach

NASA Astrophysics Data System (ADS)

Lam, Polo C.-H.; Abagyan, Ruben; Totrov, Maxim

2018-01-01

Ligand docking to flexible protein molecules can be efficiently carried out through ensemble docking to multiple protein conformations, either from experimental X-ray structures or from in silico simulations. The success of ensemble docking often requires the careful selection of complementary protein conformations, through docking and scoring of known co-crystallized ligands. False positives, in which a ligand in a wrong pose achieves a better docking score than that of native pose, arise as additional protein conformations are added. In the current study, we developed a new ligand-biased ensemble receptor docking method and composite scoring function which combine the use of ligand-based atomic property field (APF) method with receptor structure-based docking. This method helps us to correctly dock 30 out of 36 ligands presented by the D3R docking challenge. For the six mis-docked ligands, the cognate receptor structures prove to be too different from the 40 available experimental Pocketome conformations used for docking and could be identified only by receptor sampling beyond experimentally explored conformational subspace.

Prediction of binding poses to FXR using multi-targeted docking combined with molecular dynamics and enhanced sampling

NASA Astrophysics Data System (ADS)

Bhakat, Soumendranath; Åberg, Emil; Söderhjelm, Pär

2018-01-01

Advanced molecular docking methods often aim at capturing the flexibility of the protein upon binding to the ligand. In this study, we investigate whether instead a simple rigid docking method can be applied, if combined with multiple target structures to model the backbone flexibility and molecular dynamics simulations to model the sidechain and ligand flexibility. The methods are tested for the binding of 35 ligands to FXR as part of the first stage of the Drug Design Data Resource (D3R) Grand Challenge 2 blind challenge. The results show that the multiple-target docking protocol performs surprisingly well, with correct poses found for 21 of the ligands. MD simulations started on the docked structures are remarkably stable, but show almost no tendency of refining the structure closer to the experimentally found binding pose. Reconnaissance metadynamics enhances the exploration of new binding poses, but additional collective variables involving the protein are needed to exploit the full potential of the method.

Prediction of binding poses to FXR using multi-targeted docking combined with molecular dynamics and enhanced sampling.

PubMed

Bhakat, Soumendranath; Åberg, Emil; Söderhjelm, Pär

2018-01-01

Advanced molecular docking methods often aim at capturing the flexibility of the protein upon binding to the ligand. In this study, we investigate whether instead a simple rigid docking method can be applied, if combined with multiple target structures to model the backbone flexibility and molecular dynamics simulations to model the sidechain and ligand flexibility. The methods are tested for the binding of 35 ligands to FXR as part of the first stage of the Drug Design Data Resource (D3R) Grand Challenge 2 blind challenge. The results show that the multiple-target docking protocol performs surprisingly well, with correct poses found for 21 of the ligands. MD simulations started on the docked structures are remarkably stable, but show almost no tendency of refining the structure closer to the experimentally found binding pose. Reconnaissance metadynamics enhances the exploration of new binding poses, but additional collective variables involving the protein are needed to exploit the full potential of the method.

Astronaut Charles Conrad trims hair of Astronaut Paul Weitz

NASA Technical Reports Server (NTRS)

1973-01-01

Astronaut Charles Conrad Jr., Skylab 2 commander, trims the hair of Astronaut Paul J. Weitz, Skylab 2 pilot, during the 28-day Skylab 2 mission in Earth orbit. They are in the crew quarters wardroom of the Orbital Workshop of the Skylab 1 and 2 space station. Weitz is holding a vacuum hose in his right hand. This picture was taken by Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot.

SKYLAB PRIME CREW IN BLDG. 5

NASA Image and Video Library

1973-03-19

S73-20236 (1 March 1973) --- The three members of the prime crew of the first manned Skylab mission dine on specially prepared Skylab space food in the wardroom of the crew quarters of the Skylab Orbital Workshop (OWS) trainer during Skylab training at the Johnson Space Center. They are, left to right, scientist-astronaut Joseph P. Kerwin, science pilot; astronaut Paul J. Weitz, pilot; and astronaut Charles Conrad Jr., commander. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment X-Ray Stellar Classes, proposed by Joe Reihs of Baton Rouge, Louisiana. This experiment utilized Skylab's X-Ray Spectrographic Telescope to observe and determine the general characteristics and location of x-ray sources. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Multiple receptor conformation docking, dock pose clustering and 3D QSAR studies on human poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.

PubMed

Fatima, Sabiha; Jatavath, Mohan Babu; Bathini, Raju; Sivan, Sree Kanth; Manga, Vijjulatha

2014-10-01

Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. Three-dimensional quantitative structure activity relationship (3D QSAR) models were developed using comparative molecular field analysis, comparative molecular similarity indices analysis and docking studies. A set of 88 molecules were docked into the active site of six X-ray crystal structures of poly(ADP-ribose)polymerase-1 (PARP-1), by a procedure called multiple receptor conformation docking (MRCD), in order to improve the 3D QSAR models through the analysis of binding conformations. The docked poses were clustered to obtain the best receptor binding conformation. These dock poses from clustering were used for 3D QSAR analysis. Based on MRCD and QSAR information, some key features have been identified that explain the observed variance in the activity. Two receptor-based QSAR models were generated; these models showed good internal and external statistical reliability that is evident from the [Formula: see text], [Formula: see text] and [Formula: see text]. The identified key features enabled us to design new PARP-1 inhibitors.

Skylab food system

NASA Technical Reports Server (NTRS)

Turner, T. R.; Sanford, J. D.

1974-01-01

A review of the Skylab food system requirements, package designs, and launch configurations was presented. In-flight anomalies were discussed, and between-mission changes in design were described. A discussion of support for Skylab 3 and Skylab 4 mission extensions and of new items launched on these missions is included.

Lower body negative pressure: Third manned Skylab mission

NASA Technical Reports Server (NTRS)

Johnson, R. L.; Hoffler, G. W.; Nicogossian, A. E.; Bergman, S. A., Jr.; Jackson, M. M.

1974-01-01

The crew of the Skylab 4 Mission exhibited physiological changes during their 84-day mission that resembled but in several important areas did not reach the magnitude of changes exhibited in crewmen of the two earlier Skylab flights. At rest all three crewmen showed, in comparison to preflight levels, elevated mean systolic and pulse pressures and decreased mean diastolic and mean arterial pressures. Similar changes were seen in most Skylab 2 and Skylab 3 crewmen. While mean resting heart rates of both the Skylab 3 and Skylab 4 crews were elevated, those of the Skylab 2 crew were, however, lower than during preflight tests. Stressed heart rates followed previous patterns in being consistently elevated over preflight values. Postflight changes in cardiovascular parameters for the most part resembled those seen in previous crewmen of space missions. Their recovery to preflight limits occurred rapidly. In-flight data and subjective impressions of the crewmen confirmed that lower body negative pressure in weightlessness imposed a greater stress upon the cardiovascular system than in earth's gravity.

Skylab

NASA Image and Video Library

1972-05-01

One of the most successful of the Skylab educational efforts was the Skylab Student Project. This was a nationwide contest in which secondary school students submitted proposals for experiments to fly on Skylab. After the official announcement of this project, over 4,000 students responded with 3,409 proposals from which 25 winners were selected. In the subsequent evaluation of these 25 proposed experiments in terms of their suitability for flight, the Marshall Space Flight Center, the lead center for Skylab, selected 19. This photograph is a group shot of the 25 winners in the Skylab student program when they met for the first time at the Marshall Space Flight Center in May 1972.

Pulmonary function evaluation during the Skylab and Apollo-Soyuz missions.

PubMed

Sawin, C F; Nicogossian, A E; Rummel, J A; Michel, E L

1976-02-01

Previous experience during Apollo postflight exercise testing indicated no major changes in pulmonary function. Pulmonary function has been studied in detail following exposure to hypoxic and hyperoxic normal gravity environments, but no previous study has reported on men exposed to an environment that was both normoxic at 258 torr total pressure and at null gravity as encountered in Skylab. Forced vital capacity (FVC) was measured during the preflight and postflight periods of the Skylab 2 mission. Inflight measurements of vital capacity (VC) were obtained during the last 2 weeks of the second manned mission (Skylab 3). More detailed pulmonary function screening was accomplished during the Skylab 4 mission. The primary measurements made during Skylab 4 testing included residual volume determination (RV), closing volume (CV), VC, FVC and its derivatives. In addition, VC was measured in flight at regular intervals during the Skylab 4 mission. Vital capacity was decreased slightly (-10%) in flight in all Skylab 4 crewmen. No major preflight-to-postflight changes were observed. The Apollo-Soyuz Test Project (ASTP) crewmen were studied using equipment and procedures similar to those employed during Skylab 4. Postflight evaluation of the ASTP crewmen was complicated by their inadvertent exposure to nitrogen tetroxide gas fumes upon reentry.

Pulmonary function evaluation during the Skylab and Apollo-Soyuz missions

NASA Technical Reports Server (NTRS)

Sawin, C. F.; Nicogossian, A. E.; Rummel, J. A.; Michel, E. L.

1976-01-01

Previous experience during Apollo postflight exercise testing indicated no major changes in pulmonary function. Pulmonary function has been studied in detail following exposure to hypoxic and hyperoxic normal gravity environments, but no previous study has reported on men exposed to an environment that was both normoxic at 258 torr total pressure and at null gravity as encountered in Skylab. Forced vital capacity (FVC) was measured during the preflight and postflight periods of the Skylab 2 mission. Inflight measurements of vital capacity (VC) were obtained during the last 2 weeks of the second manned mission (Skylab 3). More detailed pulmonary function screening was accomplished during the Skylab 4 mission. The primary measurements made during Skylab 4 testing included residual volume determination (RV), closing volume (CV), VC, FVC and its derivatives. In addition, VC was measured in flight at regular intervals during the Skylab 4 mission. Vital capacity was decreased slightly (-10%) in flight in all Skylab 4 crewmen. No major preflight-to-postflight changes were observed. The Apollo-Soyuz Test Project (ASTP) crewmen were studied using equipment and procedures similar to those employed during Skylab 4. Postflight evaluation of the ASTP crewmen was complicated by their inadvertent exposure to nitrogen tetroxide gas fumes upon reentry.

Astronaut Paul Weitz gets physical examination from Astronaut Joseph Kerwin

NASA Technical Reports Server (NTRS)

1973-01-01

Astronaut Paul J. Weitz, Skylab 2 pilot, gets a physical examination by a fellow crewman during the 28-day Skylab 2 mission. Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot and a doctor of medicine, uses a stethoscope to check the Weitz's heartbeat. They are in the Orbital Workshop crew quarters of the Skylab 1 and 2 space station in Earth orbit. This photograph was taken by Charles Conrad Jr., Skylab 2 commander.

SKYLAB (SL)-2 - EXPERIMENTS (M-114)

NASA Image and Video Library

1973-06-05

S73-27509 (6 June 1973) --- Scientist-astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from astronaut Charles Conrad Jr., Skylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment Bacteria and Spores, proposed by Robert L. Staehle of Rochester, New York. This experiment was intended to determine the effect of the Skylab environment (particularly weightlessness) on the survival, growth rates, and mutations of certain bacteria and spores. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment Libration Clouds, proposed by Alison Hopfield of Princeton, New Jersey. This experiment utilized Skylab's astronomical telescopes to observe the two zero-force regions (Lagrangian points) within the Earth-Moon System in which small space particles were expected to accumulate. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment Ultraviolet (UV) from Quasars, proposed by John C. Hamilton of Aiea, Hawaii. This experiment utilized Skylab's Ultraviolet Stellar Astronomy equipment to photograph quasars in the UV spectrum and compare those images to existing radio and visible data. In March 1972 NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling

NASA Astrophysics Data System (ADS)

Rosenfeld, Robin J.; Goodsell, David S.; Musah, Rabi A.; Morris, Garrett M.; Goodin, David B.; Olson, Arthur J.

2003-08-01

The W191G cavity of cytochrome c peroxidase is useful as a model system for introducing small molecule oxidation in an artificially created cavity. A set of small, cyclic, organic cations was previously shown to bind in the buried, solvent-filled pocket created by the W191G mutation. We docked these ligands and a set of non-binders in the W191G cavity using AutoDock 3.0. For the ligands, we compared docking predictions with experimentally determined binding energies and X-ray crystal structure complexes. For the ligands, predicted binding energies differed from measured values by ± 0.8 kcal/mol. For most ligands, the docking simulation clearly predicted a single binding mode that matched the crystallographic binding mode within 1.0 Å RMSD. For 2 ligands, where the docking procedure yielded an ambiguous result, solutions matching the crystallographic result could be obtained by including an additional crystallographically observed water molecule in the protein model. For the remaining 2 ligands, docking indicated multiple binding modes, consistent with the original electron density, suggesting disordered binding of these ligands. Visual inspection of the atomic affinity grid maps used in docking calculations revealed two patches of high affinity for hydrogen bond donating groups. Multiple solutions are predicted as these two sites compete for polar hydrogens in the ligand during the docking simulation. Ligands could be distinguished, to some extent, from non-binders using a combination of two trends: predicted binding energy and level of clustering. In summary, AutoDock 3.0 appears to be useful in predicting key structural and energetic features of ligand binding in the W191G cavity.

Skylab Explores the Earth.

ERIC Educational Resources Information Center

National Aeronautics and Space Administration, Washington, DC.

This book describes the Skylab 4 Earth Explorations Project. Photographs of the earth taken by the Skylab astronauts are reproduced here and accompanied by an analytical and explanatory text. Some of the geological and geographical topics covered are: (1) global tectonics - some geological analyses of observations and photographs from Skylab; (2)…

Lessons in molecular recognition. 2. Assessing and improving cross-docking accuracy.

PubMed

Sutherland, Jeffrey J; Nandigam, Ravi K; Erickson, Jon A; Vieth, Michal

2007-01-01

Docking methods are used to predict the manner in which a ligand binds to a protein receptor. Many studies have assessed the success rate of programs in self-docking tests, whereby a ligand is docked into the protein structure from which it was extracted. Cross-docking, or using a protein structure from a complex containing a different ligand, provides a more realistic assessment of a docking program's ability to reproduce X-ray results. In this work, cross-docking was performed with CDocker, Fred, and Rocs using multiple X-ray structures for eight proteins (two kinases, one nuclear hormone receptor, one serine protease, two metalloproteases, and two phosphodiesterases). While average cross-docking accuracy is not encouraging, it is shown that using the protein structure from the complex that contains the bound ligand most similar to the docked ligand increases docking accuracy for all methods ("similarity selection"). Identifying the most successful protein conformer ("best selection") and similarity selection substantially reduce the difference between self-docking and average cross-docking accuracy. We identify universal predictors of docking accuracy (i.e., showing consistent behavior across most protein-method combinations), and show that models for predicting docking accuracy built using these parameters can be used to select the most appropriate docking method.

An Evaluation of Explicit Receptor Flexibility in Molecular Docking Using Molecular Dynamics and Torsion Angle Molecular Dynamics.

PubMed

Armen, Roger S; Chen, Jianhan; Brooks, Charles L

2009-10-13

Incorporating receptor flexibility into molecular docking should improve results for flexible proteins. However, the incorporation of explicit all-atom flexibility with molecular dynamics for the entire protein chain may also introduce significant error and "noise" that could decrease docking accuracy and deteriorate the ability of a scoring function to rank native-like poses. We address this apparent paradox by comparing the success of several flexible receptor models in cross-docking and multiple receptor ensemble docking for p38α mitogen-activated protein (MAP) kinase. Explicit all-atom receptor flexibility has been incorporated into a CHARMM-based molecular docking method (CDOCKER) using both molecular dynamics (MD) and torsion angle molecular dynamics (TAMD) for the refinement of predicted protein-ligand binding geometries. These flexible receptor models have been evaluated, and the accuracy and efficiency of TAMD sampling is directly compared to MD sampling. Several flexible receptor models are compared, encompassing flexible side chains, flexible loops, multiple flexible backbone segments, and treatment of the entire chain as flexible. We find that although including side chain and some backbone flexibility is required for improved docking accuracy as expected, docking accuracy also diminishes as additional and unnecessary receptor flexibility is included into the conformational search space. Ensemble docking results demonstrate that including protein flexibility leads to to improved agreement with binding data for 227 active compounds. This comparison also demonstrates that a flexible receptor model enriches high affinity compound identification without significantly increasing the number of false positives from low affinity compounds.

An Evaluation of Explicit Receptor Flexibility in Molecular Docking Using Molecular Dynamics and Torsion Angle Molecular Dynamics

PubMed Central

Armen, Roger S.; Chen, Jianhan; Brooks, Charles L.

2009-01-01

Incorporating receptor flexibility into molecular docking should improve results for flexible proteins. However, the incorporation of explicit all-atom flexibility with molecular dynamics for the entire protein chain may also introduce significant error and “noise” that could decrease docking accuracy and deteriorate the ability of a scoring function to rank native-like poses. We address this apparent paradox by comparing the success of several flexible receptor models in cross-docking and multiple receptor ensemble docking for p38α mitogen-activated protein (MAP) kinase. Explicit all-atom receptor flexibility has been incorporated into a CHARMM-based molecular docking method (CDOCKER) using both molecular dynamics (MD) and torsion angle molecular dynamics (TAMD) for the refinement of predicted protein-ligand binding geometries. These flexible receptor models have been evaluated, and the accuracy and efficiency of TAMD sampling is directly compared to MD sampling. Several flexible receptor models are compared, encompassing flexible side chains, flexible loops, multiple flexible backbone segments, and treatment of the entire chain as flexible. We find that although including side chain and some backbone flexibility is required for improved docking accuracy as expected, docking accuracy also diminishes as additional and unnecessary receptor flexibility is included into the conformational search space. Ensemble docking results demonstrate that including protein flexibility leads to to improved agreement with binding data for 227 active compounds. This comparison also demonstrates that a flexible receptor model enriches high affinity compound identification without significantly increasing the number of false positives from low affinity compounds. PMID:20160879

Rational Drug Discovery of HCV Helicase Inhibitor: Improved Docking Accuracy with Multiple Seeding in AutoDock Vina and In Situ Minimization.

PubMed

Lim, See K; Othman, Rozana; Yusof, Rohana; Heh, Choon H

2017-01-01

Hepatitis C is a significant cause for end-stage liver diseases and liver transplantation which affects approximately 3% of the global populations. Despite the current several direct antiviral agents in the treatment of Hepatitis C, the standard treatment for HCV infection is accompanied by several drawbacks, such as adverse side effects, high pricing of medications and the rapid emerging rate of resistant HCV variants. To discover potential inhibitors for HCV helicase through an optimized in silico approach. In this study, a homology model (HCV Genotype 3 helicase) was used as the target and screened through a benzopyran-based virtual library. Multiple-seedings of AutoDock Vina and in situ minimization were to account for the non-deterministic nature of AutoDock Vina search algorithm and binding site flexibility, respectively. ADME/T and interaction analyses were also done on the top hits via FAFDRUG3 web server and Discovery Studio 4.5. This study involved the development of an improved flow for virtual screening via implemention of multiple-seeding screening approach and in situ minimization. With the new docking protocol, the redocked standards have shown better RMSD value in reference to their native conformations. Ten benzopyran-like compounds with satisfactory physicochemical properties were discovered to be potential inhibitors of HCV helicase. ZINC38649350 was identified as the most potential inhibitor. Ten potential HCV helicase inhibitors were discovered via a new docking optimization protocol with better docking accuracy. These findings could contribute to the discovery of novel HCV antivirals and serve as an alternative approach of in silico rational drug discovery. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Skylab

NASA Image and Video Library

1970-01-01

Shown here is the Skylab food heating and serving tray with food, drink, and utensils. The tray contained heating elements for preparing the individual food packets. The food on Skylab was a great improvement over that on earlier spaceflights. It was no longer necessary to squeeze liquified food from plastic tubes. Skylab's kitchen in the Orbital Workshop wardroom was so equipped that each crewman could select his own menu and prepare it to his own taste. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1973-01-01

This onboard photograph depicts Astronaut Owen Garriott atop the Apollo Telescope Mount, removing a film magazine (white box) from one of Skylab's solar telescopes during an Extravehicular Activity (EVA) in the second marned Skylab mission (Skylab-3). A long boom transported it back into the waiting hands of another crew member at the airlock door below. During the operation, Garriott, film, boom, and Skylab were 435 kilometers high and speeding around the Earth at 29,000 kilometers per/hour. Because they moved together with no wind resistance, there was little sense of motion.

ASTRONAUT LOUSMA, JACK - EGRESS - SKYLAB 3 COMMAND MODULE - PACIFIC

NASA Image and Video Library

1973-09-25

S73-36435 (25 Sept. 1973) --- Astronaut Jack R. Lousma, Skylab 3 pilot, egresses the Skylab 3 Command Module aboard the prime recovery ship, USS New Orleans, during recovery operations in the Pacific Ocean. Astronauts Lousma; Alan L. Bean, commander; and Owen L. Garriott, science pilot, had just completed a successful 59-day visit to the Skylab space station in Earth orbit. The Skylab 3 spacecraft splashed down in the Pacific about 230 miles southwest of San Diego, California. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment, Atmospheric Absorption of Heat, proposed by Joe B. Zmolek of Oshkosh, Wisconsin. This experiment utilized Skylab's Earth Resources Experiment spectrometers to determine the attenuation of radiant energy in the visible and near-infrared spectrums for both densely and sparsely populated areas. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

View of atmospheric wave patterns by effect of island on wind currents

NASA Image and Video Library

1973-12-14

SL4-137-3632 (February 1974) --- A photograph taken from the Skylab space station in Earth orbit illustrating an atmospheric wave pattern by the affect of a small mountainous island on wind currents. Various patterns can be seen downwind of small islands. Often a Von Karmon vortex can be seen which appears as a spiral pattern. Multiple vortices have been photographed on previous missions. This photograph illustrates a "bow wave" pattern which extends for hundreds of miles downwind from the island. The island itself is often clear when a wave pattern is formed downstream. This particular pattern is very symmetrical. These wave patterns are most common in the South Pacific. This picture was taken by a Skylab 4 crewmen using a hand-held 70mm Hasselblad camera. Photo credit: NASA

Skylab (SL)-3 Crew - KSC

NASA Image and Video Library

2006-03-21

S73-31800 (28 July 1973) --- The three crewmen of the second manned Skylab mission (Skylab 3) participate in prelaunch suiting up activities in the Manned Spacecraft Operations Building at the Kennedy Space Center on the morning of the Skylab 3 launch. They are (from foreground) astronaut Alan L. Bean, commander; scientist-astronaut Owen K. Garriott, science pilot; and astronaut Jack R. Lousma, pilot. Dr. Donald K. Slayton (left foreground), Director of Flight Crew Operations, Johnson Space Center, monitors the prelaunch activities. Skylab 3 lifted off at 7:11 a.m. (EDT), Saturday, July 28, 1973. The three astronauts were scheduled to spend 59 days at the Skylab space station in Earth orbit. Photo credit: NASA

Anthropometric changes and fluid shifts

NASA Technical Reports Server (NTRS)

Thornton, W. E.; Hoffler, G. W.; Rummel, J. A.

1977-01-01

In an effort to obtain the most comprehensive and coherent picture of changes under weightlessness, a set of measurements on Skylab 2 was initiated and at every opportunity, additional studies were added. All pertinent information from ancillary sources were gleaned and collated. On Skylab 2, the initial anthropometric studies were scheduled in conjunction with muscle study. A single set of facial photographs was made in-flight. Additional measurements were made on Skylab 3, with photographs and truncal and limb girth measurements in-flight. Prior to Skylab 4, it was felt there was considerable evidence for large and rapid fluid shifts, so a series of in-flight volume and center of mass measurements and infrared photographs were scheduled to be conducted in the Skylab 4 mission. A number of changes were properly documented for the first time, most important of which were the fluid shifts. The following description of Skylab anthropometrics address work done on Skylab 4 primarily.

Astronaut Alan Bean shaves while aboard Skylab

NASA Technical Reports Server (NTRS)

1973-01-01

Astronaut Alan L. Bean, Skylab 3 commander, uses battery powered shaver while in the crew quarters of the Skylab space station's Orbital Workshop (OWS) crew quarters. This photograph was taken with a 35mm Nikon camera held by one of Bean's fellow crewmen during the 56.5 day second manned Skylab mission in Earth orbit.

Exact docking flight controller for autonomous aerial refueling with back-stepping based high order sliding mode

NASA Astrophysics Data System (ADS)

Su, Zikang; Wang, Honglun; Li, Na; Yu, Yue; Wu, Jianfa

2018-02-01

Autonomous aerial refueling (AAR) exact docking control has always been an intractable problem due to the strong nonlinearity, the tight coupling of the 6 DOF aircraft model and the complex disturbances of the multiple environment flows. In this paper, the strongly coupled nonlinear 6 DOF model of the receiver aircraft which considers the multiple flow disturbances is established in the affine nonlinear form to facilitate the nonlinear controller design. The items reflecting the influence of the unknown flow disturbances in the receiver dynamics are taken as the components of the "lumped disturbances" together with the items which have no linear correlation with the virtual control variables. These unmeasurable lumped disturbances are estimated and compensated by a specially designed high order sliding mode observer (HOSMO) with excellent estimation property. With the compensation of the estimated lumped disturbances, a back-stepping high order sliding mode based exact docking flight controller is proposed for AAR in the presence of multiple flow disturbances. Extensive simulation results demonstrate the feasibility and superiority of the proposed docking controller.

Skylab

NASA Image and Video Library

1970-01-01

Shown here is the Skylab food heating and serving tray in its stowed position. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Catalog of Skylab information

NASA Technical Reports Server (NTRS)

1974-01-01

Reference materials related to the Skylab Program which were produced through October, 1974 are catalogued. Six categories are listed: publications, films, television tapes, exhibits, photographs, and Skylab reports.

Skylab

NASA Image and Video Library

1973-01-01

This striking image of Skylab was photographed by Astronaut Jack Lousma (Skylab-3), as the second crew reached the orbiting laboratory over the delta of the mighty Amazon River. Skylab's solar arrays were exposed directly to the Sun's rays. Solar energy was transformed into electrical power for operation of all spacecraft systems. The proper operation of these solar arrays was vital to the mission.

MSFC Skylab operations support summary

NASA Technical Reports Server (NTRS)

Martin, J. R.

1974-01-01

A summary of the actions and problems involved in preparing the Skylab-one vehicle is presented. The subjects discussed are: (1) flight operations support functions and organization, (2) launch operations and booster flight support functions and organization, (3) Skylab launch vehicle support teams, (4) Skylab orbital operations support performance analysis, (5) support manning and procedures, and (6) data support and facilities.

Skylab Food Heating and Serving Tray

NASA Technical Reports Server (NTRS)

1970-01-01

Shown here is the Skylab food heating and serving tray with food, drink, and utensils. The tray contained heating elements for preparing the individual food packets. The food on Skylab was a great improvement over that on earlier spaceflights. It was no longer necessary to squeeze liquified food from plastic tubes. Skylab's kitchen in the Orbital Workshop wardroom was so equipped that each crewman could select his own menu and prepare it to his own taste. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Astronaut Jack Lousma seen outside Skylab space station during EVA

NASA Image and Video Library

1973-08-06

S73-31976 (5 Aug. 1973) --- Astronaut Jack R. Lousma, Skylab 3 pilot, is seen outside the Skylab space station in Earth orbit during the Aug. 5, 1973 Skylab 3 extravehicular activity (EVA) in this photographic reproduction taken from a television transmission made by a color TV camera aboard the space station. Scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, participated in the EVA with Lousma. During the EVA the two crewmen deployed the twin pole solar shield to help shade the Orbital Workshop. Photo credit: NASA

Observing earth from Skylab

NASA Technical Reports Server (NTRS)

1975-01-01

Skylab technology and observations of earth resources are discussed. Special attention was given to application of Skylab data to mapmaking, geology/geodesy, water resources, oceanography, meteorology, and geography/ecology.

Skylab

NASA Image and Video Library

1973-01-01

This chart lists the various experiments that flew on Skylab, along with their assigned numerical designations. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1972-01-01

This chart details Skylab's Time and Motion experiment (M151), a medical study to measure performance differences between tasks undertaken on Earth and the same tasks performed by Skylab crew members in orbit. Data collected from this experiment evaluated crew members' zero-gravity behavior for designs and work programs for future space exploration. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Arabella

NASA Technical Reports Server (NTRS)

1973-01-01

Arabella, a common cross spider, spins an earthly web aboard the second Skylab mission in 1973 after initial disoriented attempts. The experiment, Web Formation in Zero Gravity, part of the Skylab Student Project, was submitted by Judith Miles, a junior at Lexington High School in Lexington, Massachusetts. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments, including the Skylab Student Project.

Skylab

NASA Image and Video Library

1974-07-26

In this photograph, a skylab-4 astronaut performs Extra Vehicular Activities (EVA) outside of the lab. The third crew (Skylab-4) spent 84 days in the orbiting laboratory. The solar observatory was designed for full exposure to the Sun throughout most of the Skylab mission. Solar energy was transformed into electrical power for operation of all spacecraft systems. The proper operation of these solar arrays was vital to the mission.

Skylab

NASA Image and Video Library

1970-01-01

This photograph shows a telescopic camera for ultraviolet star photography for Skylab's Ultraviolet Panorama experiment (S183) placed in the Skylab airlock. The S183 experiment was designed to obtain ultraviolet photographs, at three wavelengths, of hot stars, clusters of stars, large stellar clouds in the Milky Way, and nuclei of other galaxies. The Marshall Space Flight Center had program responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1970-11-18

After the end of the Apollo missions, NASA's next adventure into space was the marned spaceflight of Skylab. Using an S-IVB stage of the Saturn V launch vehicle, Skylab was a two-story orbiting laboratory, one floor being living quarters and the other a work room. The objectives of Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. At the Marshall Space Flight Center (MSFC), astronauts and engineers spent hundreds of hours in an MSFC Neutral Buoyancy Simulator (NBS) rehearsing procedures to be used during the Skylab mission, developing techniques, and detecting and correcting potential problems. The NBS was a 40-foot deep water tank that simulated the weightlessness environment of space. This photograph shows astronaut Ed Gibbon (a prime crew member of the Skylab-4 mission) during the neutral buoyancy Skylab extravehicular activity training at the Apollo Telescope Mount (ATM) mockup. One of Skylab's major components, the ATM was the most powerful astronomical observatory ever put into orbit to date.

Results of Skylab medical experiment M171: Metabolic activity

NASA Technical Reports Server (NTRS)

Michel, E. L.; Rummel, J. A.; Sawin, C. F.; Buderer, M. C.; Lem, J. D.

1974-01-01

The experiment was conducted to establish whether man's ability to perform mechanical work would be progressively altered as a result of exposure to the weightless environment of space flight. The Skylab crewmen exercised on a bicycle ergometer at workloads approximating 25, 50, and 75 percent of their maximum aerobic capacity. The physiological parameters monitored were respiratory gas exchange, blood pressure, and vectorcardiogram/heart rate. The results of these tests indicate that the crewmen had no significant decrement in their responses to exercise during their exposure to zero gravity. The results of the third manned Skylab mission (Skylab 4) are presented and a comparison is made of the overall results obtained from the three successively longer Skylab manned missions. The Skylab 4 crewmembers' 84-day in-flight responses to exercise were no worse and were probably better than the responses of the crewmen on the first two Skylab missions. Indications that exercise was an important contributing factor in maintaining this response are discussed.

Skylab

NASA Image and Video Library

1973-05-25

This is an image of the Saturn IB vehicle that lifted off on May 25, 1973, carrying the crew of the Skylab-2 (SL-2) mission. The Saturn IV launch vehicle was used to carry a crew of three astronauts to the Skylab. The SL-2 mission launched the first crew to the Skylab; astronauts Charles "Pete" Conrad, Joseph Kerwin and Paul Weitz. This crew made urgent repair work on the damaged Skylab to make it operational and habitable. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The duration of this mission was 28 days.

iScreen: world's first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan

NASA Astrophysics Data System (ADS)

Tsai, Tsung-Ying; Chang, Kai-Wei; Chen, Calvin Yu-Chian

2011-06-01

The rapidly advancing researches on traditional Chinese medicine (TCM) have greatly intrigued pharmaceutical industries worldwide. To take initiative in the next generation of drug development, we constructed a cloud-computing system for TCM intelligent screening system (iScreen) based on TCM Database@Taiwan. iScreen is compacted web server for TCM docking and followed by customized de novo drug design. We further implemented a protein preparation tool that both extract protein of interest from a raw input file and estimate the size of ligand bind site. In addition, iScreen is designed in user-friendly graphic interface for users who have less experience with the command line systems. For customized docking, multiple docking services, including standard, in-water, pH environment, and flexible docking modes are implemented. Users can download first 200 TCM compounds of best docking results. For TCM de novo drug design, iScreen provides multiple molecular descriptors for a user's interest. iScreen is the world's first web server that employs world's largest TCM database for virtual screening and de novo drug design. We believe our web server can lead TCM research to a new era of drug development. The TCM docking and screening server is available at http://iScreen.cmu.edu.tw/.

iScreen: world's first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan.

PubMed

Tsai, Tsung-Ying; Chang, Kai-Wei; Chen, Calvin Yu-Chian

2011-06-01

The rapidly advancing researches on traditional Chinese medicine (TCM) have greatly intrigued pharmaceutical industries worldwide. To take initiative in the next generation of drug development, we constructed a cloud-computing system for TCM intelligent screening system (iScreen) based on TCM Database@Taiwan. iScreen is compacted web server for TCM docking and followed by customized de novo drug design. We further implemented a protein preparation tool that both extract protein of interest from a raw input file and estimate the size of ligand bind site. In addition, iScreen is designed in user-friendly graphic interface for users who have less experience with the command line systems. For customized docking, multiple docking services, including standard, in-water, pH environment, and flexible docking modes are implemented. Users can download first 200 TCM compounds of best docking results. For TCM de novo drug design, iScreen provides multiple molecular descriptors for a user's interest. iScreen is the world's first web server that employs world's largest TCM database for virtual screening and de novo drug design. We believe our web server can lead TCM research to a new era of drug development. The TCM docking and screening server is available at http://iScreen.cmu.edu.tw/.

Skylab 4 crew at start of high altitude chamber test at KSC

NASA Technical Reports Server (NTRS)

1973-01-01

Astronaut Gerald P. Carr, fully suited, Skylab 4 commander, prepares to enter spacecraft 118 (the Skylab 4 vehicle) at the start of the high altitude chamber test at the Kennedy Space Center (KSC) (34093); The Skylab 4 crew, fully suited, are seated inside their Command Module, which has been undergoing high altitude chamber test runs at KSC after being considered as a possible rescue vehicle, if needed for the Skylab 3 crew. Facing the camera is Scientist-Astronaut Edward G. Gibson, science pilot. Astronauts Carr, commander; and William R. Pogue, pilot, are also pictured (34094).

Skylab

NASA Image and Video Library

1973-01-01

Shortly after liftoff on May 14, 1973, atmospheric drag tore off the thin metallic shield of Skylab that was designed to protect her from micro-meteorites and the Sun's intense heat. The Skylab-2 crew deployed a parasol sunshield to protect the orbiting laboratory. Concern over the possibility that materials used for the parasol would deteriorate with prolonged exposure to the Sun's rays prompted the installation of a second sunshield during the Skylab-3 mission. This time, the crew exited the space station and installed a twin-pole device to position the shield over the parasol. This photograph was taken by the Skylab-4 mission.

Skylab M518 multipurpose furnace convection analysis

NASA Technical Reports Server (NTRS)

Bourgeois, S. V.; Spradley, L. W.

1975-01-01

An analysis was performed of the convection which existed on ground tests and during skylab processing of two experiments: vapor growth of IV-VI compounds growth of spherical crystals. A parallel analysis was also performed on Skylab experiment indium antimonide crystals because indium antimonide (InSb) was used and a free surface existed in the tellurium-doped Skylab III sample. In addition, brief analyses were also performed of the microsegregation in germanium experiment because the Skylab crystals indicated turbulent convection effects. Simple dimensional analysis calculations and a more accurate, but complex, convection computer model, were used in the analysis.

View of Astronaut Owen Garriott taking video of two Skylab spiders experiment

NASA Technical Reports Server (NTRS)

1973-01-01

View of Scientist-Astronaut Owen K. Garriott, Skylab 3 science pilot, taking TV footage of Arabella and Anita, the two Skylab 3 common cross spiders 'aranous diadematus,' aboard the Skylab space station cluster in Earth orbit. During the 59 day Skylab 3 mission the two spiders Arabella and Anita, were housed in an enclosure onto which a motion picture and still camera were attached to record the spiders' attempts to build a web in the weightless environment. Note the automatic data acquisition camera (DAC) about 3.5 feet to Garriott's right (about waist level).

SKYLAB (SL)-3 CREWMEN - IN-ORBIT PRESS CONFERENCE - JSC

NASA Image and Video Library

1973-09-21

S73-34339 (21 Sept. 1973) --- Astronaut Alan L. Bean, right, Skylab 3 commander, answers a question during the Sept. 21, 1973 press conference from the Skylab space station in Earth orbit. This is a black and white reproduction taken from a television transmission made by a TV camera aboard the Skylab space station. Scientist-astronaut Owen K. Garriott, center, science pilot; and astronaut Jack R. Lousma, left, pilot, await queries from newsmen on the ground to be sent up by scientist-astronaut Story Musgrave, CAPCOM for this shift of Skylab 3. Photo credit: NASA

Skylab

NASA Image and Video Library

1972-08-21

Robert L. Staehle (center), high school student from Harley School, Rochester New York, talks with Steven Hall (advisor to Staehle) and Henry Floyd, both of the Marshall Space Flight Center (MSFC) about his experiment “Behavior of Bacteria and Bacterial Spores in the Skylab Space Environment”. He was one of the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment.

Fast and accurate grid representations for atom-based docking with partner flexibility.

PubMed

de Vries, Sjoerd J; Zacharias, Martin

2017-06-30

Macromolecular docking methods can broadly be divided into geometric and atom-based methods. Geometric methods use fast algorithms that operate on simplified, grid-like molecular representations, while atom-based methods are more realistic and flexible, but far less efficient. Here, a hybrid approach of grid-based and atom-based docking is presented, combining precalculated grid potentials with neighbor lists for fast and accurate calculation of atom-based intermolecular energies and forces. The grid representation is compatible with simultaneous multibody docking and can tolerate considerable protein flexibility. When implemented in our docking method ATTRACT, grid-based docking was found to be ∼35x faster. With the OPLSX forcefield instead of the ATTRACT coarse-grained forcefield, the average speed improvement was >100x. Grid-based representations may allow atom-based docking methods to explore large conformational spaces with many degrees of freedom, such as multiple macromolecules including flexibility. This increases the domain of biological problems to which docking methods can be applied. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Skylab Food Heating and Serving Tray

NASA Technical Reports Server (NTRS)

1970-01-01

Shown here is the Skylab food heating and serving tray in its stowed position. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows Skylab's Time and Motion experiment (M151) control unit, a medical study to measure performance differences between tasks undertaken on Earth and the same tasks performed by Skylab crew members in orbit. Data collected from this experiment evaluated crew members' zero-gravity behavior for designs and work programs for future space exploration. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1972-01-01

This photograph describes details of the telescopic camera for ultraviolet star photography for Skylab's Ultraviolet Panorama experiment (S183) placed in the Skylab airlock. The S183 experiment was designed to obtain ultraviolet photographs at three wavelengths of hot stars, clusters of stars, large stellar clouds in the Milky Way, and nuclei of other galaxies. The Marshall Space Flight Center had program responsibility for the development of Skylab hardware and experiments.

The Skylab Medical Operations Project: Recommendations to Improve Crew Health and Performance for Future Exploration Missions

NASA Technical Reports Server (NTRS)

Polk, James D.; Duncan, James M.; Davis, Jeffrey R.; Williams, Richard S.; Lindgren, Kjell N.; Mathes, Karen L.; Gillis, David B.; Scheuring, Richard A.

2009-01-01

From May of 1973 to February of 1974, the National Aeronautics and Space Administration conducted a series of three manned missions to the Skylab space station, a voluminous vehicle largely descendant of Apollo hardware, and America s first space station. The crewmembers of these three manned missions spent record breaking durations of time in microgravity (28 days, 59 days and 84 days, respectively) and gave the U.S. space program its first experiences with long-duration space flight. The program overcame a number of obstacles (including a significant crippling of the Skylab vehicle) to conduct a lauded scientific program that encompassed life sciences, astronomy, solar physics, materials sciences and Earth observation. Skylab has more to offer than the results of its scientific efforts. The operations conducted by the Skylab crews and ground personnel represent a rich legacy of operational experience. As we plan for our return to the moon and the subsequent manned exploration of Mars, it is essential to utilize the experiences and insights of those involved in previous programs. Skylab and SMEAT (Skylab Medical Experiments Altitude Test) personnel have unique insight into operations being planned for the Constellation Program, such as umbilical extra-vehicular activity and water landing/recovery of long-duration crewmembers. Skylab was also well known for its habitability and extensive medical suite; topics which deserve further reflection as we prepare for lunar habitation and missions beyond Earth s immediate sphere of influence. The Skylab Medical Operations Summit was held in January 2008. Crewmembers and medical personnel from the Skylab missions and SMEAT were invited to participate in a two day summit with representatives from the Constellation Program medical operations community. The purpose of the summit was to discuss issues pertinent to future Constellation operations. The purpose of this document is to formally present the recommendations of the Skylab and SMEAT participants.

Skylab Medical Experiments Altitude Test (SMEAT)

NASA Technical Reports Server (NTRS)

Johnston, R. S. (Compiler)

1973-01-01

The Skylab 56-day environment simulation test provided baseline biomedical data on medical experiments to be included in the Skylab program. Also identified are problems in operating life support systems and medical equipment.

The detection of geothermal areas from Skylab thermal data

NASA Technical Reports Server (NTRS)

Siegal, B. S.; Kahle, A. B.; Goetz, A. F. H.; Gillespie, A. R.; Abrams, M. J.; Pohn, H. A.

1975-01-01

Skylab-4 X-5 thermal data of the geysers area was analyzed to determine the feasibility of using midday Skylab images to detect geothermal areas. The hottest ground areas indicated on the Skylab image corresponded to south-facing barren or sparsely vegetated slopes. A geothermal area approximately 15 by 30 m coincided with one of the hottest areas indicated by Skylab. This area could not be unambiguously distinguished from the other areas which are believed to be hotter than their surroundings as a result of their topography, and micrometeorological conditions. A simple modification of a previous thermal model was performed and the predicted temperatures for the hottest slopes using representative values was in general agreement with the observed data. It is concluded that data from a single midday Skylab pass cannot be used to locate geothermal areas.

Skylab

NASA Image and Video Library

1972-08-21

Terry C. Quist (center), high school student from San Antonio, Texas, discusses his proposed Skylab experiment with Marshall Space Flight Center’s (MSFC) Henry Floyd (left), coordinator of the Skylab Student Experiment Project, and DR. Raymond Gause, scientific advisor to Quist. The student’s experiment, “Earth Orbital Neutron Analysis”, was aimed at learning more about the source of neutrons in the solar system by seeking the number and direction from which each comes. Quist was among the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment, such as Quist’s experiment, which required detector hardware.

Skylab mobile laboratory

NASA Technical Reports Server (NTRS)

Primeaux, G. R.; Larue, M. A.

1975-01-01

The Skylab mobile laboratory was designed to provide the capability to obtain necessary data on the Skylab crewmen 30 days before lift-off, within 1 hour after recovery, and until preflight physiological baselines were reattained. The mobile laboratory complex consisted of six laboratories that supported cardiovascular, metabolic, nutrition and endocrinology, operational medicine, blood, and microbiology experiments; a utility package; and two shipping containers. The objectives and equipment requirements of the Skylab mobile laboratory and the data acquisition systems are discussed along with processes such as permanently mounting equipment in the individual laboratories and methods of testing and transporting the units. The operational performance, in terms of amounts of data collected, and the concept of mobile laboratories for medical and scientific experiments are evaluated. The Skylab mobile laboratory succeeded in facilitating the data collection and sample preservation associated with the three Skylab manned flights.

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment X-Rays from Jupiter, proposed by Jearne Leventhal of Berkeley, California. This experiment was an investigation to detect x-rays from the planet Jupiter and determine any correlation with solar flare activity. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Analysis of structural dynamic data from Skylab. Volume 1: Technical discussion

NASA Technical Reports Server (NTRS)

Demchak, L.; Harcrow, H.

1976-01-01

A compendium of Skylab structural dynamics analytical and test programs is presented. These programs are assessed to identify lessons learned from the structural dynamic prediction effort and to provide guidelines for future analysts and program managers of complex spacecraft systems. It is a synopsis of the structural dynamic effort performed under the Skylab Integration contract and specifically covers the development, utilization, and correlation of Skylab Dynamic Orbital Models.

SKYLAB PRIME CREW IN BLDG. 5

NASA Image and Video Library

1973-03-19

S73-20276 (1 March 1973) --- Astronaut Paul J. Weitz, pilot of the first manned Skylab mission, lies in the lower body negative pressure device during Skylab training at Johnson Space Center. Operating the controls in the background is scientist-astronaut Joseph P. Kerwin, science pilot of the mission. They are in the work and experiments area of the crew quarters of the Skylab Orbital Workshop (OWS) trainer at JSC. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-11-01

This Skylab-4 mission onboard photograph shows Astronaut Ed Gibson getting ready to prepare his meal in the crew wardroom. The tray contained heating elements for preparing the individual food packets. The food on Skylab was a great improvement over that on earlier spaceflights. It was no longer necessary to squeeze liquified food from plastic tubes. Skylab's kitchen was so equipped that each crewman could select his own menu and prepare it to his own taste.

Saturn Apollo Program

NASA Image and Video Library

1973-05-01

SA-206 lifts off from Kennedy Space Center's launch complex 39B, in Florida, on May 25, 1973, for the first manned Skylab mission (SL-2) with astronauts Pete Conrad, Joseph Kerwin, and Paul Weitz. The Saturn IB, developed under the direction of the Marshall Space Flight Center (MSFC), launched five manned Earth-orbital missions between 1968 and 1975: Apollo 7, Skylab 2, Skylab 3, Skylab 4, and the Apollo-Soyuz Test Project (ASTP).

Skylab viscous damper study

NASA Technical Reports Server (NTRS)

1978-01-01

The proposed magnetically anchored viscous fluid damper can maintain the Skylab in a gravity-gradient stabilized mode at the anticipated reboost altitudes. The parameters influencing damper performance (and thereby affecting the degree of risk) are: (1) amount of skylab pitch bias in the orbit plane which will result from aerodynamic trim conditions of the post-reboost configuration Skylab; (2) the lowest altitude to which the post-reboost Skylab will be allowed to decay prior to the next rendezvous; (3) maximum allowable weight and size of the proposed damper in order to match shuttle/TRS mission constraints; (4) the amount of magnetic materials expected to be in the vicinity of the damper.

View of Astronaut Owen Garriott taking video of two Skylab spiders experiment

NASA Image and Video Library

1973-08-16

SL3-109-1345 (August 1973) --- View of scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, taking TV footage of Arabella and Anita, the two Skylab 3 common cross spiders "aranous diadematus," aboard the Skylab space station cluster in Earth orbit. During the 59-day Skylab 3 mission the two spiders Arabella and Anita, were housed in an enclosure onto which a motion picture and still camera were attached to record the spiders' attempts to build a web in the weightless environment. Note the automatic data acquisition camera (DAC) about 3.5 feet to Garriott's right (about waist level). Photo credit: NASA

Skylab: A chronology

NASA Technical Reports Server (NTRS)

Newkirk, R. W.; Ertel, I. D.; Brooks, C. G.

1977-01-01

The Skylab Program was specifically designed to conduct a series of experiments from beyond the earth's atmosphere. Since the number and types of experiments conducted during the operational phase of Skylab were constantly changing, rather than encumber the body of the chronology with these changes, a lengthy appendix on experiments is included in this document. This appendix identifies the principle investigators and coinvestigators; gives the types, numbers, and descriptions of the experiments; explains the purpose of the various experiments; and, where possible, gives the results or findings of the experiments. The body of the Skylab chronology is divided into three parts; early space station activities, Apollo applications, and Skylab development and operations.

SKYLAB IV - PRELAUNCH (KSC)

NASA Image and Video Library

1973-11-16

S73-36905 (8 Nov. 1973) --- Astronaut William R. Pogue, pilot of the Skylab 4 mission, relaxes during spacesuit pressure and fit checks at the Kennedy Space Center, Florida. This shoulder and head shot of Pogue was taken a few days before the scheduled Skylab 4 launch. This third and last visit to the Skylab space station in Earth orbit will return additional information on the Earth and sun, as well as provide favorable location from which to observe the recently discovered Comet Kohoutek. The other two members of the Skylab 4 crew will be astronaut Gerald P. Carr, commander; and scientist-astronaut Edward G. Gibson, science pilot. Photo credit: NASA

SKYLAB IV - PRELAUNCH (KSC)

NASA Image and Video Library

1973-11-16

S73-36908 (8 Nov. 1973) --- Astronaut Gerald P. Carr, commander of the Skylab 4 mission, undergoes spacesuit pressure and fit checks at the Kennedy Space Center, Florida. This shoulder and head shot of Carr was taken a few days before the scheduled Skylab 4 launch. This third and last visit to the Skylab space station in Earth orbit will return additional information on the Earth and sun, as well as provide a favorable location from which to observe the recently discovered Comet Kohoutek. The other two members of the Skylab 4 crew will be astronaut William R. Pogue, pilot; and scientist-astronaut Edward G. Gibson, science pilot. Photo credit: NASA

SKYLAB III - POSTLAUNCH (MISSION CONTROL CENTER [MCC]) - JSC

NASA Image and Video Library

1973-08-06

S73-31964 (5 August 1973) --- This group of flight controllers discuss today's approaching extravehicular activity (EVA) to be performed by the Skylab 3 crewmen. They are, left to right, scientist-astronaut Story Musgrave, a Skylab 3 spacecraft communicator; Robert Kain and Scott Millican, both of the Crew Procedures Division, EVA Procedures Section; William C. Schneider, Skylab Program Director, NASA Headquarters; and Milton Windler, flight director. Windler points to the model of the Skylab space station cluster to indicate the location of the ATM's film magazines. The group stands near consoles in the Mission Operations Control Room (MOCR) of the JSC Mission Control Center (MCC). Photo credit: NASA

Convection effects on Skylab experiments M551, M552, and M553, phase C report. [metal melting, exothermic brazing, and sphere forming under weightless conditions

NASA Technical Reports Server (NTRS)

Bourgeois, S. V.

1973-01-01

This report described an analysis of Skylab Experiments M551 (Metals Melting), M552 (Exothermic Brazing), and M553 (Sphere Forming). The primary objective is the study of convection in the molten metals and their attendant solidification theory. Particular attention is given to clarifying the effects of reduced gravity on molten metal flow and solidification. Based on an analysis of physical forces and solidification theory expected for ground-based and Skylab processing, low-g variations were predicted for each experiment. A comparison was then made with the Skylab results available to date. Both metallurgical analyses of other investigators and movies of ground-based and Skylab samples were utilized. Several low-g variations in Skylab processed materials were successfully predicted based on expected variations in physical forces and fluid convection. The same analysis also successfully predicted several features in the Skylab-processed materials which were identical to terrestrially-processed materials. These results are summarized in the conclusion section for each experiment.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows Skylab's Ultraviolet (UV) Stellar Astronomy experiment, a scientific airlock-based facility/experiment that would study UV spectra of early-type stars and galaxies. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Astronaut Charles Conrad Jr. working with control panel in Skylab simulation

NASA Image and Video Library

1973-02-01

S73-16765 (1 Feb. 1973) --- Astronaut Charles Conrad Jr. is seen working with the control panels of the Skylab Orbital Workshop trainer during Skylab training at the Johnson Space Center. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

This photograph was taken during the Skylab-3 mission (2nd marned mission), showing Astronaut Owen Garriott enjoying his meal in the Orbital Workshop crew wardroom. The tray contained heating elements for preparing the individual food packets. The food on Skylab was a great improvement over that on earlier spaceflights. It was no longer necessary to squeeze liquified food from plastic tubes. Skylab's kitchen was so equipped that each crewman could select his own menu and prepare it to his own taste.

Skylab medical experiments program. [for in-flight human physiological adaptive processes

NASA Technical Reports Server (NTRS)

Hessberg, R. R.

1973-01-01

With the completion of the historic Apollo Program, the significant medical findings will be reviewed and the medical results summarized. The medical objectives of Skylab will be presented. The medical experiments which will be conducted and their relationship to the Apollo medical findings and Skylab objectives will be discussed. The interrelationship of the Skylab medical experiments will be described and the anticipated information to be obtained will be postulated.

Evaluation of Skylab earth laser beacon imagery. [spaceborne photography

NASA Technical Reports Server (NTRS)

Piech, K. R.; Schott, J. R.

1975-01-01

During the Skylab 3 and 4 missions the Skylab spacecraft was illuminated by a low power argon ion and dye laser. The earth laser beacon was studied visually by the astronauts. In addition, they collected 35 mm hand-held color photographs of the beacons. Photographs are shown that were obtained on Skylab 3 and Skylab 4. The imagery collected during the Skylab mission was analyzed to evaluate the utility of beacon lasers as terrestial 'artificial stars' for space navigation. The analyses of the imagery revealed two unusual features of the earth laser beacon: (1) The beacon, even though of a low power (approximately 1 watt), is considerably brighter than any other terrain feature and is readily visible on imagery at a distance in excess of 1500 km (900 miles). (2) Another feature of the beacon is its large size. The typical beacon extends over about 5 resolution areas with a characteristic dimension of about 200 m.

Evaluation of the suitability of Skylab data for the purpose of petroleum exploration

NASA Technical Reports Server (NTRS)

Collins, R. J. (Principal Investigator); Petzel, G.; Everett, J. R.

1975-01-01

The author has identified the following significant results. Comparisons of the various photographic bands of Skylab imagery indicate that, overall, standard color (particularly S190B) is the most valuable for geological purposes. Detailed examination of all bands indicates that as with ERTS imagery each band contains useful information that is unique to it. The results of geological interpretations based on ERTS and Skylab imagery are strikingly similar. It appears that more information can be extracted from a single Skylab overpass than a single ERTS overpass, but that with repeated passes the lower resolution ERTS imagery may yield information comparable to that contained in S190B imagery. Comparison of Skylab photography to high altitude aircraft photography suggests that there are distinct advantages to using Skylab imagery for regional geologic interpretations. This is primarily because of the synoptic view provided by the space acquired imagery allows and encourages integration of regional geologic features.

Emblem for the second manned Skylab mission, Skylab 3

NASA Technical Reports Server (NTRS)

1973-01-01

This is the emblem for the second manned Skylab mission. It will be a mission of up to 56 days. The patch symbolizes the main objectives of the flight. The central figure, adapted from one by Leonardo da Vinci, illustrates the proportions of the human form and suggests the many studies of man himself to be conducted in the zero-gravity environment of space. This drawing is superimposed on two hemispheres representing the two additional main areas of research - studies of the Sun and the development of techniques for survey of the Earth's resources. The left hemisphere show the Sun as it will be seen in the red light radiated by hydrogen atoms in the solar atmosphere. The right hemisphere is intended to suggest the studies of Earth resources to be conducted on Skylab. Although the patch denotes this mission as Skylab II, it is actually consided to be the Skylab III mission.

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.

PubMed

Farid, Ramy; Day, Tyler; Friesner, Richard A; Pearlstein, Robert A

2006-05-01

We created a homology model of the homo-tetrameric pore domain of HERG using the crystal structure of the bacterial potassium channel, KvAP, as a template. We docked a set of known blockers with well-characterized effects on channel function into the lumen of the pore between the selectivity filter and extracellular entrance using a novel docking and refinement procedure incorporating Glide and Prime. Key aromatic groups of the blockers are predicted to form multiple simultaneous ring stacking and hydrophobic interactions among the eight aromatic residues lining the pore. Furthermore, each blocker can achieve these interactions via multiple docking configurations. To further interpret the docking results, we mapped hydrophobic and hydrophilic potentials within the lumen of each refined docked complex. Hydrophilic iso-potential contours define a 'propeller-shaped' volume at the selectivity filter entrance. Hydrophobic contours define a hollow 'crown-shaped' volume located above the 'propeller', whose hydrophobic 'rim' extends along the pore axis between Tyr652 and Phe656. Blockers adopt conformations/binding orientations that closely mimic the shapes and properties of these contours. Blocker basic groups are localized in the hydrophilic 'propeller', forming electrostatic interactions with Ser624 rather than a generally accepted pi-cation interaction with Tyr652. Terfenadine, cisapride, sertindole, ibutilide, and clofilium adopt similar docked poses, in which their N-substituents bridge radially across the hollow interior of the 'crown' (analogous to the hub and spokes of a wheel), and project aromatic/hydrophobic portions into the hydrophobic 'rim'. MK-499 docks with its longitudinal axis parallel to the axis of the pore and 'crown', and its hydrophobic groups buried within the hydrophobic 'rim'.

Multiple Exposure of Rendezvous Docking Simulator - Gemini Program

NASA Image and Video Library

1964-02-07

Multiple exposure of Rendezvous Docking Simulator. Francis B. Smith, described the simulator as follows: The rendezvous and docking operation of the Gemini spacecraft with the Agena and of the Apollo Command Module with the Lunar Excursion Module have been the subject of simulator studies for several years. This figure illustrates the Gemini-Agena rendezvous docking simulator at Langley. The Gemini spacecraft was supported in a gimbal system by an overhead crane and gantry arrangement which provided 6 degrees of freedom - roll, pitch, yaw, and translation in any direction - all controllable by the astronaut in the spacecraft. Here again the controls fed into a computer which in turn provided an input to the servos driving the spacecraft so that it responded to control motions in a manner which accurately simulated the Gemini spacecraft. -- Published in Barton C. Hacker and James M. Grimwood, On the Shoulders of Titans: A History of Project Gemini, NASA SP-4203 Francis B. Smith, Simulators for Manned Space Research, Paper presented at the 1966 IEEE International convention, March 21-25, 1966.

Combining Machine Learning Systems and Multiple Docking Simulation Packages to Improve Docking Prediction Reliability for Network Pharmacology

PubMed Central

Hsin, Kun-Yi; Ghosh, Samik; Kitano, Hiroaki

2013-01-01

Increased availability of bioinformatics resources is creating opportunities for the application of network pharmacology to predict drug effects and toxicity resulting from multi-target interactions. Here we present a high-precision computational prediction approach that combines two elaborately built machine learning systems and multiple molecular docking tools to assess binding potentials of a test compound against proteins involved in a complex molecular network. One of the two machine learning systems is a re-scoring function to evaluate binding modes generated by docking tools. The second is a binding mode selection function to identify the most predictive binding mode. Results from a series of benchmark validations and a case study show that this approach surpasses the prediction reliability of other techniques and that it also identifies either primary or off-targets of kinase inhibitors. Integrating this approach with molecular network maps makes it possible to address drug safety issues by comprehensively investigating network-dependent effects of a drug or drug candidate. PMID:24391846

Skylab Dental Examination

NASA Technical Reports Server (NTRS)

1973-01-01

Skylab 2 Commander Charles Conrad is seen undergoing a dental examination by the Medical Officer, Joseph Kerwin in the Skylab Medical Facility. In the absence of an examination chair, Conrad simply rotated his body to an upside down position to facilitate the procedure.

Skylab reuse study, reference data. Part 2: Appendixes

NASA Technical Reports Server (NTRS)

1978-01-01

Contents: (1) evaluations of the dysbarism risk associated with a Skylab revisit by shuttle; (2) mission model/payload data sheets; (3) life sciences utilization of on-board Skylab medical facilities; (4) airlock module description; and (5) orbital workshop description.

Lessons learned on the Skylab program

NASA Technical Reports Server (NTRS)

1974-01-01

Lessons learned in the Skylab program and their application and adaptation to other space programs are summarized. Recommendations and action taken on particular problems are described. The use of Skylab recommendations to identify potential problems of future space programs is discussed.

Skylab experiment M487 habitability/crew quarters

NASA Technical Reports Server (NTRS)

Johnson, C. C.

1975-01-01

Results of Skylab experiment M487 (habitability/crew quarters), which was designed to evaluate the habitability features of Skylab, were presented. General observations and conclusions drawn from the data obtained are presented in detail. The objectives of the experiment, the manner in which data was acquired, and the instruments used to support the experiments are described. Illustrations and photographs of the living and work areas of Skylab and some of the habitability features are provided. Samples of the subjective evaluation questionnaires used by the crewmen are included. Habitability-related documents, crewmen biographies, functional characteristics and photographs of the instruments used, and details of Skylab compartment sizes and color schemes are included as appendixes.

Skylab 4 crewmen passing trash bags in to the OWS waste disposal tank

NASA Technical Reports Server (NTRS)

1974-01-01

Two Skylab 4 crewmen are seen passing trash bags through the trash airlock of the Orbital Workshop (OWS) of the Skylab space station in Earth orbit. The trash airlock leads to the OWS waste disposal tank. Astronaut William R. Pogue, Skylab 4 pilot, holds onto the OWS crew quarters ceiling as he prepares to jump onto the OWS airlock hatch cover to force another trash bag further down into the airlock. Astronaut Gerald P. Carr, Skylab 4 commander, is assisting. Carr is holding onto the trash bags. A third trash bag is floating in the zero-gravity environment near Pogue's right leg. The wardroom can be seen behind Pogue.

Skylab

NASA Image and Video Library

1972-08-21

Kathy Jackson, high school student from Houston, Texas, discusses her experiment with Dr. Robert Allen (left) and her scintific advisor Arthur White, both of the Marshall Space Flight Center (MSFC). Miss Jackson’s experiment tested the motor sensory performance of an astronaut at various times during the Skylab flight to detect any degredation in his eye-hand coordination. She was one of the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment.

Microgravity

NASA Image and Video Library

2004-04-15

Comparison of ground-based (left) and Skylab (right) electron beam welds in pure tantalum (Ta) (10X magnification). Residual votices left behind in the ground-based sample after the electron beam passed were frozen into the grain structure. These occurred because of the rapid cooling rate at the high temperature. Although the thermal characteristics and electron beam travel speeds were comparable for the skylab sample, the residual vortices were erased in the grain structure. This may have been due to the fact that final grain size of the solidified material was smaller in the Skylab sample compared to the ground-based sample. The Skylab sample was processed in the M512 Materials Processing Facility (MPF) during Skylab SL-2 Mission. Principal Investigator was Richard Poorman.

Art Concepts- Skylab (Sun Shade)

NASA Image and Video Library

1973-05-18

S73-26127 (1973) --- An artist's concept of the Skylab space station cluster in Earth orbit illustrating the deployment of the twin pole thermal shield to shade the Orbital Workshop (OWS) from the sun. This is one of the sunshade possibilities considered to solve the problem of the overheated OWS. Here the two Skylab 2 astronauts have completely deployed the sunshade. Note the evidence of another Skylab problem - the solar panels on the OWS are not deployed as required. Photo credit: NASA

Skylab

NASA Image and Video Library

1967-09-01

This September 1967 photograph shows workmen removing a mockup of the Saturn V S-IVB stage that housed the Skylab Orbital Workshop (OWS) from the Marshall Space Flight Center (MSFC), building 4755. The mockup was shipped to McDornell Douglas in Huntington, California for design modifications. NASA used the mockup as an engineering design tool to plan structures, equipment, and experiments for Skylab, an orbiting space laboratory. The MSFC had program management responsibility for the development of Skylab hardware and experiments, including the OWS.

Skylab

NASA Image and Video Library

1970-01-01

This chart describes Skylab's Particle Collection device, a scientific experiment designed to study micro-meteoroid particles in near-Earth space and determine their abundance, mass distribution, composition, and erosive effects. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1970-01-01

This photograph shows Skylab's Particle Collection device, a scientific experiment designed to study micro-meteoroid particles in near-Earth space and determine their abundance, mass distribution, composition, and erosive effects. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Fluid shifts in weightlessness

NASA Technical Reports Server (NTRS)

Thornton, William E.; Moore, Thomas P.; Pool, Sam L.

1987-01-01

Studies of leg volumes in space by multiple girth measurements showed reductions of 1.9 l (12.8 percent of leg volume), with 1.1 l from the nondominant leg, on Skylab 4. On landing, 65 percent of postflight leg volume increase was complete at 1.5 h. Measurement of the dominant leg during the equivalent period on Shuttle showed a mean loss of 0.9 l which was 90-percent complete at 150 min. Postflight increases were 87-percent complete at 1.5 h postlanding. Mass measurements during and after Skylab 4 showed a loss of 2.5 kg over the first 4 d on orbit, with a gain of 2.7 kg over the first 4 d of recovery. These changes are assumed to be tissue fluids secondary to changes in hydrostatic pressures and are much greater than those seen in bed rest. Rate and magnitude of inflight and postflight changes have significant operational impact.

Urban and regional land use analysis: CARETS and Census Cities experiment package

NASA Technical Reports Server (NTRS)

Alexander, R. H. (Principal Investigator); Milazzo, V. A.

1973-01-01

The author has identified the following significant results. Areas of post 1970 and 1972 land use changes were identified solely from the Skylab imagery from comparisons with 1970 land use maps. Most land use changes identified involved transition from agriculture to single family residential land use. The second most prominent changes identified from the Skylab imagery were areas presently under construction. Post 1970 changes from Skylab were compared with the 1972 changes noted from the high altitude photographs. A good correlation existed between the change polygons mapped from Skylab and those mapped from the 1972 high altitude aerial photos. In addition, there were a number of instances where additional built-up land use not noted in the 1972 aerial photo as being developed were identified on the Skylab imagery. While these cases have not been documented by field observation, by correlating these areas with the appearance of similar land use areas whose identity has been determined, we can safely say that we have been able to map further occurrences of land use change beyond existing high altitude photo coverage from the Skylab imagery. It was concluded that Skylab data can be used to detect areas of land use change within an urban setting.

BP-Dock: A Flexible Docking Scheme for Exploring Protein–Ligand Interactions Based on Unbound Structures

PubMed Central

Bolia, Ashini; Gerek, Z. Nevin; Ozkan, S. Banu

2016-01-01

Molecular docking serves as an important tool in modeling protein–ligand interactions. However, it is still challenging to incorporate overall receptor flexibility, especially backbone flexibility, in docking due to the large conformational space that needs to be sampled. To overcome this problem, we developed a novel flexible docking approach, BP-Dock (Backbone Perturbation-Dock) that can integrate both backbone and side chain conformational changes induced by ligand binding through a multi-scale approach. In the BP-Dock method, we mimic the nature of binding-induced events as a first-order approximation by perturbing the residues along the protein chain with a small Brownian kick one at a time. The response fluctuation profile of the chain upon these perturbations is computed using the perturbation response scanning method. These response fluctuation profiles are then used to generate binding-induced multiple receptor conformations for ensemble docking. To evaluate the performance of BP-Dock, we applied our approach on a large and diverse data set using unbound structures as receptors. We also compared the BP-Dock results with bound and unbound docking, where overall receptor flexibility was not taken into account. Our results highlight the importance of modeling backbone flexibility in docking for recapitulating the experimental binding affinities, especially when an unbound structure is used. With BP-Dock, we can generate a wide range of binding site conformations realized in nature even in the absence of a ligand that can help us to improve the accuracy of unbound docking. We expect that our fast and efficient flexible docking approach may further aid in our understanding of protein–ligand interactions as well as virtual screening of novel targets for rational drug design. PMID:24380381

ConsDock: A new program for the consensus analysis of protein-ligand interactions.

PubMed

Paul, Nicodème; Rognan, Didier

2002-06-01

Protein-based virtual screening of chemical libraries is a powerful technique for identifying new molecules that may interact with a macromolecular target of interest. Because of docking and scoring limitations, it is more difficult to apply as a lead optimization method because it requires that the docking/scoring tool is able to propose as few solutions as possible and all of them with a very good accuracy for both the protein-bound orientation and the conformation of the ligand. In the present study, we present a consensus docking approach (ConsDock) that takes advantage of three widely used docking tools (Dock, FlexX, and Gold). The consensus analysis of all possible poses generated by several docking tools is performed sequentially in four steps: (i) hierarchical clustering of all poses generated by a docking tool into families represented by a leader; (ii) definition of all consensus pairs from leaders generated by different docking programs; (iii) clustering of consensus pairs into classes, represented by a mean structure; and (iv) ranking the different means starting from the most populated class of consensus pairs. When applied to a test set of 100 protein-ligand complexes from the Protein Data Bank, ConsDock significantly outperforms single docking with respect to the docking accuracy of the top-ranked pose. In 60% of the cases investigated here, ConsDock was able to rank as top solution a pose within 2 A RMSD of the X-ray structure. It can be applied as a postprocessing filter to either single- or multiple-docking programs to prioritize three-dimensional guided lead optimization from the most likely docking solution. Copyright 2002 Wiley-Liss, Inc.

DOCKSCORE: a webserver for ranking protein-protein docked poses.

PubMed

Malhotra, Sony; Mathew, Oommen K; Sowdhamini, Ramanathan

2015-04-24

Proteins interact with a variety of other molecules such as nucleic acids, small molecules and other proteins inside the cell. Structure-determination of protein-protein complexes is challenging due to several reasons such as the large molecular weights of these macromolecular complexes, their dynamic nature, difficulty in purification and sample preparation. Computational docking permits an early understanding of the feasibility and mode of protein-protein interactions. However, docking algorithms propose a number of solutions and it is a challenging task to select the native or near native pose(s) from this pool. DockScore is an objective scoring scheme that can be used to rank protein-protein docked poses. It considers several interface parameters, namely, surface area, evolutionary conservation, hydrophobicity, short contacts and spatial clustering at the interface for scoring. We have implemented DockScore in form of a webserver for its use by the scientific community. DockScore webserver can be employed, subsequent to docking, to perform scoring of the docked solutions, starting from multiple poses as inputs. The results, on scores and ranks for all the poses, can be downloaded as a csv file and graphical view of the interface of best ranking poses is possible. The webserver for DockScore is made freely available for the scientific community at: http://caps.ncbs.res.in/dockscore/ .

MSFC Skylab electrical power systems mission evaluation

NASA Technical Reports Server (NTRS)

Woosley, A. P.

1974-01-01

The design, development, and operation of the Skylab electrical power system are discussed. The electrical systems for the airlock module of the orbital workshop and the Apollo telescope mount are described. Skylab is considered an integral laboratory, however, both cluster and module hardware distinct sections are included. Significant concept and requirement evolution, testing, and modifications resulting from tests are briefly summarized to aid in understanding the launch configuration description and the procedures and performance discussed for in-orbit operation. Specific problems encountered during Skylab orbital missions are analyzed.

Physiological and psychological stress limits for astronautics Observations during the Skylab I-III missions

NASA Technical Reports Server (NTRS)

Burchard, E. C.

1975-01-01

The physiological and psychological factors of manned space flight had a particular significance in the Skylab missions during which astronauts were subjected to a life in a space environment for longer periods of time than on previous space missions. The Skylab missions demonstrated again the great adaptability of human physiology to the environment of man. The results of Skylab have indicated also approaches for enhancing the capability of man to tolerate the physiological and psychological stresses of space flight.

Skylab 2 astronauts seen in wardroom of crew quarters of Skylab 1 station

NASA Technical Reports Server (NTRS)

1973-01-01

Two of the three Skylab 2 astronauts are seen in the wardroom of the crew quarters of the Orbital Workshop of the Skylab 1 space station cluster in Earth orbit in this reproduction taken from a color television transmission made by a TV camera aboard the space station. They are preparing to eat a meal. Astronaut Charles Conrad Jr., commander, is in the right foreground. In the background is scientist-astronaut Joseph P. Kerwin, science pilot.

View of Arabella, one of two Skylab spiders and her web

NASA Technical Reports Server (NTRS)

1973-01-01

A close-up view of Arabella, one of the two Skylab 3 common cross spiders 'aranous diadematus,' and the web it had spun in the zero gravity of space aboard the Skylab space station cluster in Earth orbit. During the 59 day Skylab 3 mission the two spiders Arabella and Anita, were housed in an enclosure onto which a motion picture and still camera were attached to record the spiders' attempts to build a web in the weightless environment.

ASTRONAUT KERWIN, JOSEPH P. - EXTRAVEHICULAR ACTIVITY (EVA) - SKYLAB (SL)-2

NASA Image and Video Library

1973-06-01

S73-27562 (June 1973) --- Scientist-astronaut Joseph P. Kerwin, Skylab 2 science pilot, performs extravehicular activity (EVA) at the Skylab 1 and 2 space station cluster in Earth orbit, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the station. Kerwin is just outside the Airlock Module. Kerwin assisted astronaut Charles Conrad Jr., Skylab 2 commander, during the successful EVA attempt to free the stuck solar array system wing on the Orbital Workshop. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment In-Vitro Immunology, proposed by Todd A. Meister of Jackson Heights, New York. He suggested an in-vitro observation of the effects of zero-gravity on a presipitin-type antigen-antibody reaction, as compared with the same reaction carried out in an Earth-based laboratory. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab experiments. Volume 7: Living and working in space. [Skylab mission data on human factors engineering and spacecraft components for high school level education

NASA Technical Reports Server (NTRS)

1973-01-01

Experiments conducted on the Skylab vehicle that will measure and evaluate the ability of the crew to live and work effectively in space are discussed. The methods and techniques of human engineering as they relate to the design and evaluation of work spaces, requirements, and tools are described. The application of these methods and the Skylab measurements to the design of future spacecraft are analyzed.

Skylab

NASA Image and Video Library

1970-01-01

This photograph shows Skylab's Galactic X-Ray Mapping facility (S150), an astrophysics and space sciences investigation. An objective of this experiment was to extend the search for the origin of galactic x-rays beyond the sensitivity possible with short flights of small research rockets. This was accomplished by placing a large-area, soft x-ray detector in orbit to collect data for a much longer time. The S150 instrument was not in Skylab but in the instrument unit of the second stage of the Skylab-3 Saturn IB rocket.

Phase 1 research program overview

NASA Technical Reports Server (NTRS)

Uri, J. J.; Lebedev, O. N.

2001-01-01

The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success. c2001 AIAA. Published by Elsevier Science Ltd.

Phase 1 research program overview.

PubMed

Uri, J J; Lebedev, O N

2001-01-01

The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success. c2001 AIAA. Published by Elsevier Science Ltd.

Skylab short-lived event alert program

NASA Technical Reports Server (NTRS)

Citron, R. A.

1974-01-01

During the three manned Skylab missions, the Center for Short-Lived Phenomena (CSLP) reported a total of 39 significant events to the Johnson Space Center (JSC) as part of the Skylab Short-Lived Event Alert Program. The telegraphed daily status reports included the names and locations of the events, the track number and revolution number during which the event could be observed, the time (GMT) to within plus or minus 2 sec when Skylab was closest to the event area, and the light condition (daylight or darkness) at that time and place. The messages sent to JSC during the Skylab 4 mission also included information pertaining to ground-truth studies and observations being conducted on the events. Photographic priorities were assigned for each event.

Skylab

NASA Image and Video Library

1972-08-21

Rockford, Illinois high school student, Vincent Converse, discussed his proposed Skylab experiment with Dr. Robert Head (right) and Gene Greshman of Marshall Space Flight Center (MSFC). His experiment, “Zero Gravity Mass Measurement” used a simple leaf spring with the mass to be weighed attached to the end. The electronic package oscillated the spring at a specific rate and the results were recorded electronically. Converse was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment, such as that of Converse’s experiment.

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment Ultraviolet (UV) From Pulsars, proposed by Neal W. Sharnon of Atlanta, Georgia. This experiment was to observe several pulsars with Skylab's UV spectrometer to determine their intensities in that portion of their spectra. A more detailed description of a pulsar's electromagnetic emission profile would be expected to further define means by which its energy is released. Unfortunately, upon examination of the photographic plates containing the data from the experiment, it was found that an alignment error of the spectrometer prevented detection of any of the pulsars. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab 3 crewmen practice in the MDA

NASA Image and Video Library

1973-07-25

S73-31322 (30 June 1973) --- The three prime crewmen of the Skylab 3 mission practice procedures which will be used during the extravehicular activity (EVA) portion of the scheduled Skylab rate gyro six-pac installation. They are scientist-astronaut Owen K. Garriott (center), astronaut Alan L. Bean (center background) and astronaut Jack R. Lousma (right). Garriott is working with a mock-up of a trunion plug plate which is on the space station's deployment assembly. This picture was taken during Skylab 3 prelaunch training at Johnson Space Center. In the left foreground with back to camera is astronaut Russell L. Schweickart, who is assisting with the Skylab 3 training. Another training officer is in the left background. Photo credit: NASA

Floodlights illuminate view of Skylab 3 vehicle at Pad B, Launch Complex 39

NASA Image and Video Library

1973-07-20

S73-32568 (20 July 1973) --- Floodlights illuminate this nighttime view of the Skylab 3/Saturn 1B space vehicle at Pad B, Launch Complex 39, Kennedy Space Center, Florida, during prelaunch preparations. The reflection is the water adds to the scene. In addition to the Command/Service Module and its launch escapte system, the Skylab 3 space vehicle consists of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-IVB) stage. The crew for the scheduled 59-day Skylab 3 mission in Earth orbit will be astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma. Skylab 3 was launched on July 28, 1973. Photo credit: NASA

Particle Collections - Skylab Experiment S149

NASA Technical Reports Server (NTRS)

1970-01-01

This photograph shows Skylab's Particle Collection device, a scientific experiment designed to study micro-meteoroid particles in near-Earth space and determine their abundance, mass distribution, composition, and erosive effects. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Particle Collection - Skylab Experiment S149

NASA Technical Reports Server (NTRS)

1970-01-01

This chart describes Skylab's Particle Collection device, a scientific experiment designed to study micro-meteoroid particles in near-Earth space and determine their abundance, mass distribution, composition, and erosive effects. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Astronaut Alan Bean looks over data acquisition camera on Skylab trainer

NASA Technical Reports Server (NTRS)

1972-01-01

Astronaut Alan L. Bean, commander for Skylab 3, the second manned Skylab mission, looks over the data acquisition camera mounted on the water tank in the upper level of the Orbital Workshop (OWS) one-G trainer at the Manned Spacecraft Center (MSC).

A multilevel multispectral data set analysis in the visible and infrared wavelength regions. [for land use remote sensing

NASA Technical Reports Server (NTRS)

Biehl, L. L.; Silva, L. F.

1975-01-01

Skylab multispectral scanner data, digitized Skylab color infrared (IR) photography, digitized Skylab black and white multiband photography, and Earth Resources Technology Satellite (ERTS) multispectral scanner data collected within a 24-hr time period over an area in south-central Indiana near Bloomington on June 9 and 10, 1973, were compared in a machine-aided land use analysis of the area. The overall classification performance results, obtained with nine land use classes, were 87% correct classification using the 'best' 4 channels of the Skylab multispectral scanner, 80% for the channels on the Skylab multispectral scanner which are spectrally comparable to the ERTS multispectral scanner, 88% for the ERTS multispectral scanner, 83% for the digitized color IR photography, and 76% for the digitized black and white multiband photography. The results indicate that the Skylab multispectral scanner may yield even higher classification accuracies when a noise-filtered multispectral scanner data set becomes available in the near future.

Web Formation - Skylab Student Experiment ED-52

NASA Technical Reports Server (NTRS)

1973-01-01

This chart describes the Skylab student experiment Web Formation. Judith S. Miles of Lexington High School, Lexington, Massachusetts, proposed a study of the spider's behavior in a weightless environment. The geometrical structure of the web of the orb-weaving spider provides a good measure of the condition of its central nervous system. Since the spider senses its own weight to determine the required thickness of web material and uses both the wind and gravity to initiate construction of its web, the lack of gravitational force in Skylab provided a new and different stimulus to the spider's behavioral response. Two common cross spiders, Arabella and Anita, were used for the experiment aboard the Skylab-3 mission. After initial disoriented attempts, both spiders produced almost Earth-like webs once they had adapted to weightlessness. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment Web Formation. Judith S. Miles of Lexington High School, Lexington, Massachusetts, proposed a study of the spider's behavior in a weightless environment. The geometrical structure of the web of the orb-weaving spider provides a good measure of the condition of its central nervous system. Since the spider senses its own weight to determine the required thickness of web material and uses both the wind and gravity to initiate construction of its web, the lack of gravitational force in Skylab provided a new and different stimulus to the spider's behavioral response. Two common cross spiders, Arabella and Anita, were used for the experiment aboard the Skylab-3 mission. After initial disoriented attempts, both spiders produced almost Earth-like webs once they had adapted to weightlessness. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab

NASA Image and Video Library

1972-06-02

One of the most successful of the Skylab educational efforts was the Skylab Student Project. A nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA) in which secondary students were encouraged to submit proposals for experiments to be conducted on Skylan in Earth orbit the following year. After the official announcement of this project, over 4,000 students responded with 3,409 proposals. The winning 25 students, along with their parents and sponsor teachers, visited Marshall Space Flight Center (MSFC), the lead center for Skylab, where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. This photograph is a group shot of the 25 winners, parents, and sponsors when they met for the first time on the steps of Building 4200 at MSFC in the Spring of 1972.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows Skylab's Ultraviolet (UV)/X-Ray Solar Photography instrument, an Apollo Telescope Mount (ATM) facility designed to photograph normal and explosive areas in the solar atmosphere in the x-ray and UV spectra. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab, Classroom in Space.

ERIC Educational Resources Information Center

Summerlin, Lee B., Ed.

In the Skylab student project, high school students submitted proposals for experiments that could be performed on board Skylab by the astronauts. This book describes the experiments designed by the students and reports what happened to those experiments in the space laboratory. The student experiments included studies of the central nervous…

Skylab

NASA Image and Video Library

1972-01-01

This chart details Skylab's Ultraviolet (UV) X-Ray Solar Photography experiment (S020) in an Apollo Telescope Mount facility. It was designed to photograph normal and explosive areas within the solar atmosphere in the UV and x-ray spectra. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Stabilizing a spinning Skylab

NASA Technical Reports Server (NTRS)

Seltzer, S. M.; Patel, J. S.; Justice, D. W.; Schweitzer, G. E.

1972-01-01

The results are presented of a study of the dynamics of a spinning Skylab space station. The stability of motion of several simplified models with flexible appendages was investigated. A digital simulation model that more accurately portrays the complex Skylab vehicle is described, and simulation results are compared with analytically derived results.

Skylab

NASA Image and Video Library

1973-01-01

This chart describes scientific parameters of the Skylab Ultraviolet (UV) Scanning Polychromator Spectroheliometer, one the eight Apollo Telescope Mount facilities. It was designed to observe and provide temporal changes in UV radiation emitted by the Sun's chromosphere and lower corona. The Marshall Space Flight Center had program management responsibility for the development of skylab hardware and experiments.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows the flight unit for Skylab's Ultraviolet (UV) Scarning Polychromator Spectroheliometer, an Apollo Telescope Mount (ATM) facility. It was designed to observe temporal changes in UV radiation emitted by the Sun's chromosphere and lower corona. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab Trash Airlock

NASA Technical Reports Server (NTRS)

Price, L. R.

1975-01-01

The Skylab Trash Airlock (TAL) used throughout the Skylab mission to transfer trash materials that could support microbial growth from the pressurized cabin to the unpressurized waste tank is described. The TAL, which uses several basic mechanisms, was successfully operated daily for the 170 days of manned missions for a total of 637 cycles.

Skylab

NASA Image and Video Library

1972-09-01

This photograph shows the Skylab Orbital Workshop (OWS) assembled, with its Thruster Attitude Control System (TACS) and radiator, ready for placing on the transporter. Twenty-two titanium spheres above the radiator housed the nitrogen required for operation of the TACS. At one end of the OWS, the TACS provided short-term control of the attitude of the Skylab.

Skylab-3 Mission Onboard Photograph - Astronaut Bean working on Experiment S019

NASA Technical Reports Server (NTRS)

1973-01-01

This Skylab-3 mission onboard photograph shows Astronaut Alan Bean operating the Ultraviolet (UV) Stellar Astronomy experiment (S019) in the Skylab Airlock Module. The S019, a camera with a prism for UV star photography, studied the UV spectra of early-type stars and galaxies.

Astronaut Owen Garriott trims hair of Astronaut Alan Bean

NASA Image and Video Library

1973-08-19

SL3-108-1292 (19 Aug. 1973) --- Scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, trims the hair of astronaut Alan L. Bean, commander, in this onboard photograph from the Skylab Orbital Workshop (OWS) in Earth orbit. Astronaut Jack R. Lousma, pilot, took this picture with a 35mm Nikon camera. Bean holds a vacuum hose to gather in loose hair. The crew of the second manned Skylab flight went on to successfully complete 59 days aboard the Skylab space station cluster in Earth orbit. Photo credit: NASA

Skylab Medical Experiments Altitude Test /SMEAT/ facility design and operation.

NASA Technical Reports Server (NTRS)

Hinners, A. H., Jr.; Correale, J. V.

1973-01-01

This paper presents the design approaches and test facility operation methods used to successfully accomplish a 56-day test for Skylab to permit evaluation of selected Skylab medical experiments in a ground test simulation of the Skylab environment with an astronaut crew. The systems designed for this test include the two-gas environmental control system, the fire suppression and detection system, equipment transfer lock, ground support equipment, safety systems, potable water system, waste management system, lighting and power system, television monitoring, communications and recreation systems, and food freezer.

View of Arabella, one of the two Skylab 3 spiders used in experiment

NASA Technical Reports Server (NTRS)

1973-01-01

A close-up view of Arabella, one of the two Skylab 3 common cross spiders 'Araneus diadematus,' and the web it had spun in the zero gravity of space aboard the Skylab space station cluster in Earth orbit. This is a photographic reproduction made from a color television transmission aboard Skylab. Arabella and Anita, were housed in an enclosure onto which a motion picture camera and a still camera were attached to record the spiders' attempts to build a web in the weightless environment.

In-Vitro Immunology - Skylab Student Experiment ED-31

NASA Technical Reports Server (NTRS)

1973-01-01

This chart describes the Skylab student experiment In-Vitro Immunology, proposed by Todd A. Meister of Jackson Heights, New York. He suggested an in-vitro observation of the effects of zero-gravity on a presipitin-type antigen-antibody reaction, as compared with the same reaction carried out in an Earth-based laboratory. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab (SL)-3 Crewmen - Checklist - Crew Quarters - Orbital Workshop Simulator (OWS) Trainer - JSC

NASA Image and Video Library

1973-01-01

S73-28793 (16 July 1973) --- The three crewmen of the second manned Skylab mission (Skylab 3) go over a checklist during preflight training at the Johnson Space Center. They are, left to right, scientist-astronaut Owen K. Garriott, science pilot; astronaut Alan L. Bean, commander; and astronaut Jack R. Lousma, pilot. They are in the crew quarters of the Orbital Workshop trainer in the Mission Training and Simulation Facility, Building 5, at JSC. Skylab 3 is scheduled as a 59-day mission in Earth orbit. Photo credit: NASA

Retention and application of Skylab experiences to future programs. [a postflight review of technical programs.

NASA Technical Reports Server (NTRS)

Gillespie, V. G.; Kelly, R. O.

1974-01-01

The problems encountered and special techniques and procedures developed on the Skylab program are described along with the experiences and practical benefits obtained for dissemination and use on future programs. Three major topics are discussed: electrical problems, mechanical problems, and special techniques. Special techniques and procedures are identified that were either developed or refined during the Skylab program. These techniques and procedures came from all manufacturing and test phases of the Skylab program and include both flight and GSE items from component level to sophisticated spaceflight systems.

SKYLAB (SL)-2 - RECOVERY OPERATIONS - PACIFIC OCEAN

NASA Image and Video Library

1973-06-26

S73-29147 (22 June 1973) --- The Skylab 2 Command Module, with astronauts Charles Conrad Jr., Joseph P. Kerwin and Paul J. Weitz still inside, floats in the Pacific Ocean following successful splashdown about 835 miles southwest of San Diego, California. The prime recovery ship, USS Ticonderoga, approaches from the left background. A recovery helicopter hovers in the foreground. The three Skylab 2 crewmen had just completed a 28-day stay with the Skylab 1 space station in Earth orbit conducting numerous medical, scientific and technological experiments. Photo credit: NASA

SKYLAB (SL)-3 - ASTRONAUT GARRIOTT, OWEN

NASA Image and Video Library

1973-08-09

S73-32113 (9 Aug. 1973) --- Scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, serves as test subject for the Skylab ?Human Vestibular Function? M131 Experiment, as seen in this photographic reproduction taken from a television transmission made by a color TV camera aboard the Skylab space station in Earth orbit. The objectives of the Skylab M131 experiment are to obtain data pertinent to establishing the validity of measurements of specific behavioral/physiological responses influenced by vestibular activity under one-g and zero-g conditions; to determine man?s adaptability to unusual vestibular conditions and predict habitability of future spacecraft conditions involving reduced gravity and Coriollis forces; and to measure the accuracy and variability in man?s judgment of spatial coordinates based on atypical gravity receptor cues and inadequate visual cues. Photo credit: NASA

Assessing an ensemble docking-based virtual screening strategy for kinase targets by considering protein flexibility.

PubMed

Tian, Sheng; Sun, Huiyong; Pan, Peichen; Li, Dan; Zhen, Xuechu; Li, Youyong; Hou, Tingjun

2014-10-27

In this study, to accommodate receptor flexibility, based on multiple receptor conformations, a novel ensemble docking protocol was developed by using the naïve Bayesian classification technique, and it was evaluated in terms of the prediction accuracy of docking-based virtual screening (VS) of three important targets in the kinase family: ALK, CDK2, and VEGFR2. First, for each target, the representative crystal structures were selected by structural clustering, and the capability of molecular docking based on each representative structure to discriminate inhibitors from non-inhibitors was examined. Then, for each target, 50 ns molecular dynamics (MD) simulations were carried out to generate an ensemble of the conformations, and multiple representative structures/snapshots were extracted from each MD trajectory by structural clustering. On average, the representative crystal structures outperform the representative structures extracted from MD simulations in terms of the capabilities to separate inhibitors from non-inhibitors. Finally, by using the naïve Bayesian classification technique, an integrated VS strategy was developed to combine the prediction results of molecular docking based on different representative conformations chosen from crystal structures and MD trajectories. It was encouraging to observe that the integrated VS strategy yields better performance than the docking-based VS based on any single rigid conformation. This novel protocol may provide an improvement over existing strategies to search for more diverse and promising active compounds for a target of interest.

Skylab IV - Television

NASA Image and Video Library

1973-12-26

S73-38687 (24 Dec. 1973) --- This "Christmas tree" was created by the three crewmen of the third manned Skylab mission (Skylab 4) aboard the space station in Earth orbit. Food cans were used to fashion the tree. This photograph was made from a television transmission made from a video tape recording on Dec. 24, 1973. Photo credit: NASA

Astronaut Alan Bean looks over data acquisition camera on Skylab trainer

NASA Image and Video Library

1972-09-01

S72-39256 (1972) --- Astronaut Alan L. Bean, commander for Skylab 3, the second manned Skylab mission, looks over the data acquisition camera mounted on the water tank in the upper level of the Orbital Workshop (OWS) one-G trainer at the Manned Spacecraft Center (MSC). Photo credit: NASA

Skylab

NASA Image and Video Library

1971-01-01

This 1971 photograph was taken during the assembly of the Flight Article of the Skylab Airlock Module (AM). The Am, fabricated by McDornell Douglas under the direction of the Marshall Flight Center, allowed Skylab crew members an exit to perform extravehicular activities. The Module also contained many of the supplies and control panels for electrical power distribution and internal environment.

ARTIST CONCEPT - CUTAWAY VIEW SKYLAB 1 ORBITAL WORKSHOP (OWS)

NASA Image and Video Library

1973-05-23

S73-23919 (May 1973) --- An artist's concept illustrating a cutaway view of the Skylab 1 Orbital Workshop (OWS). The OWS is one of the five major components of the Skylab 1 space station cluster which was launched by a Saturn V on May 14, 1973 into Earth orbit. Photo credit: NASA

Artist Concept - Illustration Cutaway View - Skylab (SL)-1 Orbital Workshop (OWS)

NASA Image and Video Library

1973-05-23

S73-23918 (May 1973) --- An artist's concept illustrating a cutaway view of the Skylab 1 Orbital Workshop (OWS). The OWS is one of the five major components of the Skylab 1 space station cluster which was launched by a Saturn V on May 14, 1973 into Earth orbit. Photo credit: NASA

Skylab, Space Shuttle, Space Benefits Today and Tomorrow.

ERIC Educational Resources Information Center

National Aeronautics and Space Administration, Washington, DC.

The pamphlet "Skylab" describes very generally the kinds of activities to be conducted with the Skylab, America's first manned space station. "Space Shuttle" is a pamphlet which briefly states the benefits of the Space Shuttle, and a concise review of present and future benefits of space activities is presented in the pamphlet "Space Benefits…

Utilizing Skylab data in on-going resources management programs in the state of Ohio

NASA Technical Reports Server (NTRS)

Baldridge, P. E. (Principal Investigator); Goesling, P. H.; Martin, T. A.; Wukelic, G. E.; Stephan, J. G.; Smail, H. E.; Ebbert, T. F.

1975-01-01

The author has identified the following significant results. The use of Skylab imagery for total area woodland surveys was found to be more accurate and cheaper than conventional surveys using aerial photo-plot techniques. Machine-aided (primarily density slicing) analyses of Skylab 190A and 190B color and infrared color photography demonstrated the feasibility of using such data for differentiating major timber classes including pines, hardwoods, mixed, cut, and brushland providing such analyses are made at scales of 1:24,000 and larger. Manual and machine-assisted image analysis indicated that spectral and spatial capabilities of Skylab EREP photography are adequate to distinguish most parameters of current, coal surface mining concern associated with: (1) active mining, (2) orphan lands, (3) reclaimed lands, and (4) active reclamation. Excellent results were achieved when comparing Skylab and aerial photographic interpretations of detailed surface mining features. Skylab photographs when combined with other data bases (e.g., census, agricultural land productivity, and transportation networks), provide a comprehensive, meaningful, and integrated view of major elements involved in the urbanization/encroachment process.

Modeling and docking antibody structures with Rosetta

PubMed Central

Weitzner, Brian D.; Jeliazkov, Jeliazko R.; Lyskov, Sergey; Marze, Nicholas; Kuroda, Daisuke; Frick, Rahel; Adolf-Bryfogle, Jared; Biswas, Naireeta; Dunbrack, Roland L.; Gray, Jeffrey J.

2017-01-01

We describe Rosetta-based computational protocols for predicting the three-dimensional structure of an antibody from sequence (RosettaAntibody) and then docking the antibody to protein antigens (SnugDock). Antibody modeling leverages canonical loop conformations to graft large segments from experimentally-determined structures as well as (1) energetic calculations to minimize loops, (2) docking methodology to refine the VL–VH relative orientation, and (3) de novo prediction of the elusive complementarity determining region (CDR) H3 loop. To alleviate model uncertainty, antibody–antigen docking resamples CDR loop conformations and can use multiple models to represent an ensemble of conformations for the antibody, the antigen or both. These protocols can be run fully-automated via the ROSIE web server (http://rosie.rosettacommons.org/) or manually on a computer with user control of individual steps. For best results, the protocol requires roughly 1,000 CPU-hours for antibody modeling and 250 CPU-hours for antibody–antigen docking. Tasks can be completed in under a day by using public supercomputers. PMID:28125104

Skylab reuse study, reference data, part 1. [habitability of the orbital workshop and airlock modules for the space transportation system

NASA Technical Reports Server (NTRS)

1978-01-01

The accommodations provided by the airlock module and the orbital workshop were completely examined with the thought of total reactivation as an enhancement to the STS long duration missions. Each subsystem is described and a summary of subsystem performance during the Skylab missions is presented. End-of-mission status and the status of today for each subsystem is shown together with refurbishment/resupply requirements and refurb kit descriptions to restore Skylab to full operational capability. An inspection/refurbishment and operations plan for Skylab is included. The initial Shuttle-tended operational activity would provide a safe, effective phase of Skylab rehabilitation while simultaneously benefitting the Orbiter crew through the addition of private accommodations, off-duty recreation area, and physical conditioning equipment. This period would also permit exercising selected onboard experiments.

SKYLAB (SL)-4 - POSTLAUNCH - JSC

NASA Image and Video Library

1973-11-21

S73-37030 (November 1973) --- The procedures for repairing the coolant system aboard the Airlock Module of the Skylab space station in Earth orbit are discussed by flight controllers in the Mission Operations Control Room in the Mission Control Center at Johnson Space Center. Skylab 4 flight director Neil Hutchinson is on the right. Astronaut Russell L. Schweickart is wearing the sports shirt. Astronaut Bruce McCandless II, a Skylab 4 CAPCOM, is seated next to Schweickart. Items of equipment in the foreground are similar to components of a special coolant re-servicing kit which was taken to Earth orbit by the Skylab 4 crewmen. The kit consists of a tank containing 42 pounds of COOLANOL, a series of saddle valves, bolts and spacers, and leak-check hoses. The re-supply tank is a modified command module reaction control subsystem (RCS) fuel tank. Photo credit: NASA

Spider Anita - Skylab (SL)

NASA Image and Video Library

1973-08-27

S73-33164 (27 Aug. 1973) --- A close-up view of Anita, one of the two common cross spiders “Araneus diadematus” aboard Skylab, is seen in this photographic reproduction of a color television transmission made by a TV camera aboard the Skylab space station in Earth orbit. A finger of one of the Skylab 3 crewmen points to Anita. The two spiders are housed in an enclosure onto which a motion picture and still camera are attached to record the spider’s attempt to build a web in the zero-gravity of space. The spider experiment (ED52) is one of 25 experiments selected by NASA for Skylab from more than 3,400 experiment proposals submitted by high school students throughout the nation. ED52 was submitted by 17-year old Judith S. Miles of Lexington, Mass. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

Vincent W. Converse of Rockford, Illinois proposed Skylab's student experiment ED-74, Mass Measurement, to measure mass in a weightless environment. This chart describes Converse's experiment. Mass is the quantity of matter in any object. The gravitational force between an object and the Earth is called weight, which is a result of the Earth's gravity acting upon the object's mass. Even though objects in Skylab were apparently weightless, their mass properties were unchanged. Measurement of mass is therefore an acceptable alternative to measurement of weight. The devices used in this experiment provided accurate mass measurements of the astronauts' weights, intakes, and body wastes throughout the missions. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Hazard analysis of Clostridium perfringens in the Skylab Food System

NASA Technical Reports Server (NTRS)

Bourland, C. T.; Huber, C. S.; Kiser, P. R.; Heidelbaugh, N. D.; Rowley, D. B.

1974-01-01

The Skylab Food System presented unique microbiological problems because food was warmed in null-gravity and because the heat source was limited to 69.4 C (to prevent boiling in null-gravity). For these reasons, the foods were manufactured using critical control point techniques of quality control coupled with appropriate hazard analyses. One of these hazard analyses evaluated the threat from Clostridium perfringens. Samples of food were inoculated with C. perfringens and incubated for 2 h at temperatures ranging from 25 to 55 C. Generation times were determined for the foods at various temperatures. Results of these tests were evaluated taking into consideration: food-borne disease epidemiology, the Skylab food manufacturing procedures, and the performance requirements of the Skylab Food System. Based on this hazard analysis, a limit for C. perfringens of 100/g was established for Skylab foods.

Skylab

NASA Image and Video Library

1972-06-02

Berkley, California high school student, Jeanne L. Leventhal, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; and Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew during a tour of MSFC. Leventhal was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

ATM CMG bearing failure analysis

NASA Technical Reports Server (NTRS)

1975-01-01

The cause or causes for the failure of ATM CMG S/N 5 (Skylab 1) and the anomalies associated with ATM CMG S/N 6 (Skylab 2) were investigated. Skylab telemetry data were reviewed and presented in the form of parameter distributions. The theory that the problems were caused by marginal bearing lubrication was studied along with the effects of orbital conditions on lubricants. Bearing tests were performed to investigate the effect of lubricant or lack of lubricant in the ATM CMG bearings and the dispersion and migration of the lubricant. The vacuum and weightless conditions of space were simulated in the bearing tests. Analysis of the results of the tests conducted points to inadequate lubrication as the predominant factor causing the failure of ATM CMG S/N 5 (Skylab 1) and the anomalies associated with ATM CMG S/N 6 (Skylab 2).

Low drag attitude control for Skylab orbital lifetime extension

NASA Technical Reports Server (NTRS)

Glaese, J. R.; Kennel, H. F.

1981-01-01

In the fall of 1977 it was determined that Skylab had started to tumble and that the original orbit lifetime predictions were much too optimistic. A decision had to be made whether to accept an early uncontrolled reentry with its inherent risks or try to attempt to control Skylab to a lower drag attitude in the hope that there was enough time to develop a Teleoperator Retrieval System, bring it up on the Space Shuttle and then decide whether to boost Skylab to a higher longer life orbit or to reenter it in a controlled fashion. The end-on-velocity (EOVV) control method is documented, which was successfully applied for about half a year to keep Skylab in a low drag attitude with the aid of the control moment gyros and a minimal expenditure of attitude control gas.

Human and Server Docking Prediction for CAPRI Round 30–35 Using LZerD with Combined Scoring Functions

PubMed Central

Peterson, Lenna X.; Kim, Hyungrae; Esquivel-Rodriguez, Juan; Roy, Amitava; Han, Xusi; Shin, Woong-Hee; Zhang, Jian; Terashi, Genki; Lee, Matt; Kihara, Daisuke

2016-01-01

We report the performance of protein-protein docking predictions by our group for recent rounds of the Critical Assessment of Prediction of Interactions (CAPRI), a community-wide assessment of state-of-the-art docking methods. Our prediction procedure uses a protein-protein docking program named LZerD developed in our group. LZerD represents a protein surface with 3D Zernike descriptors (3DZD), which are based on a mathematical series expansion of a 3D function. The appropriate soft representation of protein surface with 3DZD makes the method more tolerant to conformational change of proteins upon docking, which adds an advantage for unbound docking. Docking was guided by interface residue prediction performed with BindML and cons-PPISP as well as literature information when available. The generated docking models were ranked by a combination of scoring functions, including PRESCO, which evaluates the native-likeness of residues’ spatial environments in structure models. First, we discuss the overall performance of our group in the CAPRI prediction rounds and investigate the reasons for unsuccessful cases. Then, we examine the performance of several knowledge-based scoring functions and their combinations for ranking docking models. It was found that the quality of a pool of docking models generated by LZerD, i.e. whether or not the pool includes near-native models, can be predicted by the correlation of multiple scores. Although the current analysis used docking models generated by LZerD, findings on scoring functions are expected to be universally applicable to other docking methods. PMID:27654025

Technology Development of Automated Rendezvous and Docking/Capture Sensors and Docking Mechanism for the Asteroid Redirect Crewed Mission

NASA Technical Reports Server (NTRS)

Hinkel, Heather; Cryan, Scott; Zipay, John; Strube, Matthew

2015-01-01

This paper will describe the technology development efforts NASA has underway for Automated Rendezvous and Docking/Capture (AR&D/C) sensors and a docking mechanism and the challenges involved. The paper will additionally address how these technologies will be extended to other missions requiring AR&D/C whether robotic or manned. NASA needs AR&D/C sensors for both the robotic and crewed segments of the Asteroid Redirect Mission (ARM). NASA recently conducted a commonality assessment of the concept of operations for the robotic Asteroid Redirect Vehicle (ARV) and the crewed mission segment using the Orion crew vehicle. The commonality assessment also considered several future exploration and science missions requiring an AR&D/C capability. Missions considered were asteroid sample return, satellite servicing, and planetary entry, descent, and landing. This assessment determined that a common sensor suite consisting of one or more visible wavelength cameras, a threedimensional LIDAR along with long-wavelength infrared cameras for robustness and situational awareness could be used on each mission to eliminate the cost of multiple sensor developments and qualifications. By choosing sensor parameters at build time instead of at design time and, without having to requalify flight hardware, a specific mission can design overlapping bearing, range, relative attitude, and position measurement availability to suit their mission requirements with minimal nonrecurring engineering costs. The resulting common sensor specification provides the union of all performance requirements for each mission and represents an improvement over the current systems used for AR&D/C today. These sensor specifications are tightly coupled to the docking system capabilities and requirements for final docking conditions. The paper will describe NASA's efforts to develop a standard docking system for use across NASA human spaceflight missions to multiple destinations. It will describe the current design status and the considerations and technologies involved in developing this docking mechanism.

Technology Development of Automated Rendezvous and Docking/Capture Sensors and Docking Mechanism for the Asteroid Redirect Crewed Mission

NASA Technical Reports Server (NTRS)

Hinkel, Heather; Strube, Matthew; Zipay, John J.; Cryan, Scott

2015-01-01

This paper will describe the technology development efforts NASA has underway for Automated Rendezvous and Docking/Capture (AR and D/C) sensors and a docking mechanism and the challenges involved. The paper will additionally address how these technologies will be extended to other missions requiring AR and D/C whether robotic or manned. NASA needs AR&D/C sensors for both the robotic and crewed segments of the Asteroid Redirect Mission (ARM). NASA recently conducted a commonality assessment of the concept of operations for the robotic Asteroid Redirect Vehicle (ARV) and the crewed mission segment using the Orion crew vehicle. The commonality assessment also considered several future exploration and science missions requiring an AR and D/C capability. Missions considered were asteroid sample return, satellite servicing, and planetary entry, descent, and landing. This assessment determined that a common sensor suite consisting of one or more visible wavelength cameras, a threedimensional LIDAR along with long-wavelength infrared cameras for robustness and situational awareness could be used on each mission to eliminate the cost of multiple sensor developments and qualifications. By choosing sensor parameters at build time instead of at design time and, without having to requalify flight hardware, a specific mission can design overlapping bearing, range, relative attitude, and position measurement availability to suit their mission requirements with minimal nonrecurring engineering costs. The resulting common sensor specification provides the union of all performance requirements for each mission and represents an improvement over the current systems used for AR and D/C today. These sensor specifications are tightly coupled to the docking system capabilities and requirements for final docking conditions. The paper will describe NASA's efforts to develop a standard docking system for use across NASA human spaceflight missions to multiple destinations. It will describe the current design status and the considerations and technologies involved in developing this docking mechanism.

Technology Development of Automated Rendezvous and Docking/Capture Sensors and Docking Mechanism for the Asteroid Redirect Crewed Mission

NASA Technical Reports Server (NTRS)

Hinkel, Heather; Strube, Matthew; Zipay, John J.; Cryan, Scott

2016-01-01

This paper will describe the technology development efforts NASA has underway for Automated Rendezvous and Docking/Capture (AR&D/C) sensors and a docking mechanism and the challenges involved. The paper will additionally address how these technologies will be extended to other missions requiring AR&D/C whether robotic or manned. NASA needs AR&D/C sensors for both the robotic and crewed segments of the Asteroid Redirect Mission (ARM). NASA recently conducted a commonality assessment of the concept of operations for the robotic Asteroid Redirect Vehicle (ARV) and the crewed mission segment using the Orion spacecraft. The commonality assessment also considered several future exploration and science missions requiring an AR&D/C capability. Missions considered were asteroid sample return, satellite servicing, and planetary entry, descent, and landing. This assessment determined that a common sensor suite consisting of one or more visible wavelength cameras, a three-dimensional LIDAR along with long-wavelength infrared cameras for robustness and situational awareness could be used on each mission to eliminate the cost of multiple sensor developments and qualifications. By choosing sensor parameters at build-time instead of at design-time and, without having to requalify flight hardware, a specific mission can design overlapping bearing, range, relative attitude, and position measurement availability to suit their mission requirements with minimal non-recurring engineering costs. The resulting common sensor specification provides the union of all performance requirements for each mission and represents an improvement over the current systems used for AR&D/C today. These sensor specifications are tightly coupled to the docking system capabilities and requirements for final docking conditions. The paper will describe NASA's efforts to develop a standard docking system for use across NASA human spaceflight missions to multiple destinations. It will describe the current design status and the considerations and technologies involved in developing this docking mechanism.

View of Skylab space station cluster in Earth orbit from CSM

NASA Image and Video Library

1974-02-08

SL4-143-4707 (8 Feb. 1974) --- An overhead view of the Skylab space station cluster in Earth orbit as photographed from the Skylab 4 Command and Service Modules (CSM) during the final fly-around by the CSM before returning home. The space station is contrasted against a cloud-covered Earth. Note the solar shield which was deployed by the second crew of Skylab and from which a micrometeoroid shield has been missing since the cluster was launched on May 14, 1973. The OWS solar panel on the left side was also lost on workshop launch day. Photo credit: NASA

MSFC Skylab Apollo Telescope Mount summary mission report

NASA Technical Reports Server (NTRS)

Morse, A. R.

1974-01-01

A summary of the Apollo Telescope Mount (ATM) performance during the 8.5-month Skylab mission is presented. A brief description of each ATM system, system performance summaries, discussion of all significant ATM anomalies which occurred during the Skylab mission, and, in an appendix, a summary of the Skylab ATM Calibration Rocket Project (CALROC) are provided. The text is supplemented and amplified by photographs, drawings, curves, and tables. The report shows that the ATM not only met, but exceeded premission performance criteria, and that participation of man in space for this scientific investigation greatly enhanced the quality and quantity of the data attained.

SKYLAB (SL)-2 PRIME CREW - BLDG. 5 - JSC

NASA Image and Video Library

1973-03-20

S73-20713 (1 March 1973) --- Astronaut Charles Conrad Jr., commander of the first manned Skylab mission, wipes perspiration from his face following an exercise session on the bicycle ergometer during Skylab training at Johnson Space Center. Conrad is in the work and experiments compartment of the crew quarters of the Skylab Orbital Workshop (OWS) trainer at JSC. In addition to being the prime exercise for the crewmen, the ergometer is also used for the vector-cardiogram test and the metabolic activity experiment. The bicycle ergometer produces measured workloads for use in determining man's metabolic effectiveness. Photo credit: NASA

Astronaut Robert Crippen simulates preparation of Skylab meal

NASA Image and Video Library

1972-06-15

S72-41855 (15 June 1972) --- Astronaut Robert L. Crippen, Skylab Medical Experiment Altitude Test (SMEAT) commander, simulates the preparation of a Skylab meal. Crippen is a member of a three-man crew who will spend up to 56 days in the Crew Systems Division's 20-foot altitude chamber at the NASA Manned Spacecraft Center (MSC) beginning in mid-July to obtain medical data and evaluate medical experiment equipment for Skylab. The two crew members not shown in this view are astronauts Karol J. Bobko, SMEAT pilot, and Dr. William E. Thornton, SMEAT science pilot. Photo credit: NASA

Skylab

NASA Image and Video Library

1972-01-01

This set of photographs details Skylab's Human Vestibular Function experiment (M131). This experiment was a set of medical studies designed to determine the effect of long-duration space missions on astronauts' coordination abilities. This experiment tested the astronauts susceptibility to motion sickness in the Skylab environment, acquired data fundamental to an understanding of the functions of human gravity reception under prolonged absence of gravity, and tested for changes in the sensitivity of the semicircular canals. Data from this experiment was collected before, during, and after flight. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Detectability of geothermal areas using Skylab X-5 data

NASA Technical Reports Server (NTRS)

Siegal, B. S.; Kahle, A. B.; Goetz, A. F. H.; Gillespie, A. R.; Abrams, M. J.

1975-01-01

The results are presented of a study which was undertaken to determine if data from a single near-noon pass of Skylab could be used to detect geothermal areas. The size and temperature requirements for a geothermally heated area to be seen by Skylab S-192 MSS X-5 thermal sensor were calculated. This sensor obtained thermal data with the highest spatial resolution of any nonmilitary satellite system. Only very large hot areas could be expected to be unambiguously recognized with a single data set from this instrument. The study area chosen was The Geysers geothermal field in Sonoma County, California, the only geothermal area of significant size scanned by Skylab. Unfortunately, 95% of the Skylab thermal channel data was acquired within 3 hours of local noon. For The Geysers area only daytime X-5 data were available. An analysis of the thermal channel data (10.2 to 12.5 um) revealed that ground temperatures determined by Skylab were normally distributed. No anomalous hot spots were apparent. Computer enhancement techniques were used to delineate the hottest 100 and 300 ground areas (pixel, 75 m by 75 m) within the study region. It was found that the Skylab MSS with the X-5 thermal detector does not have sufficient spatial resolution to locate unambiguously from daytime data any but the largest and hottest convectively created geothermal features, which in general are prominent enough to have been previously recognized.

Skylab

NASA Image and Video Library

1972-08-21

San Antonio, Texas high school student, Terry C. Quist (left), and Dr. Raymond Gause of the Marshall Space Flight Center (MSFC), discuss the student’s experiment to be performed aboard the Skylab the following year. His experiment, “Earth Orbital Neutron Analysis” required detectors such as the one he is examining in this photo. The detector was to be attached to a water tank in Skylab. Neutrons striking the detectors left traces that were brought out by a chemical etching process after the Skylab mission. Quist’s experiment seeked to record neutron hits, count them, and determine their direction. This information was to help determine the source of neutrons in the solar system. Quist was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC two months earlier where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

President Gerald Ford holds crystal manufactured in space during Skylab 4

NASA Technical Reports Server (NTRS)

1974-01-01

President Gerald R. Ford, center, holds encased crystal manufactured in space during Skylab 4. Dr. James C. Fletcher, left, NASA Administrator, explains the article to the Chief Executive as Dr. Harold Johnson of M.I.T. looks on. The indium-antimonide crystal was formed in Earth orbit on January 6, 1974, by the Skylab 4 astronauts.

Space radiation hazards to Project Skylab photographic film, phase 2

NASA Technical Reports Server (NTRS)

Hill, C. W.; Neville, C. F.

1971-01-01

The results of a study of space radiation hazards to Project Skylab photographic film are presented. Radiation components include trapped protons, trapped electrons, bremsstrahlung, and galactic cosmic radiation. The shielding afforded by the Skylab cluster is taken into account with a 5000 volume element mathematical model. A preliminary survey of expected proton spectrometer data is reported.

Skylab program CSM verification analysis report

NASA Technical Reports Server (NTRS)

Schaefer, J. L.; Vanderpol, G. A.

1970-01-01

The application of the SINDA computer program for the transient thermodynamic simulation of the Apollo fuel cell/radiator system for the limit condition of the proposed Skylab mission is described. Results are included for the thermal constraints imposed upon the Pratt and Whitney fuel cell power capability by the Block 2 EPS radiator system operating under the Skylab fixed attitude orbits.

Skylab Experiments, Volume 7, Living and Working in Space.

ERIC Educational Resources Information Center

National Aeronautics and Space Administration, Washington, DC.

Basic knowledge about Skylab experiments is presented in this book for the purpose of informing high school teachers about scientific research performed in orbit and enabling the teachers to broaden their scope of material selection. The seventh volume deals with the ability of the Skylab crew to live and work effectively in space. The content is…

SKYLAB (SL)-4 - CREW TRAINING (ORBITAL WORKSTATION [OWS]) - JSC

NASA Image and Video Library

1973-08-22

S73-32848 (10 Sept. 1973) --- Scientist-astronaut Edward G. Gibson, science pilot for the third manned Skylab mission (Skylab 4), reads the markings on a magazine of 400 feet of film for the 16mm Data Acquisition Camera (DAC), during a training exercise in the Orbital Workshop (OWS) trainer at Johnson Space Center. Photo credit: NASA

Skylab lessons learned as applicable to a large space station, 1967-1974. Ph.D. Thesis - Catholic Univ. of Am.

NASA Technical Reports Server (NTRS)

Schneider, W. C.

1976-01-01

This report records some of the lessons learned during Skylab development. The approach taken is to list lessons which could have wide application in the development of a large space station. The lessons are amplified and explained in light of the background and experiences of the Skylab development.

Skylab experiments. Volume 6: Mechanics. [Skylab program accomplishments for high school level education

NASA Technical Reports Server (NTRS)

1973-01-01

Skylab program activities are presented in a form adapted to instruction of high school students. The overall goals of the program are discussed. The specific accomplishments of the mechanics investigations are described. The subjects involved are as follows: (1) evaluation of mobility aids, (2) mass measurement devices, and (3) space guidance crew/vehicle disturbances.

View of Arabella, one of two Skylab spiders and her web

NASA Image and Video Library

1973-08-16

SL3-108-1307 (July-September 1973) --- A close-up view of Arabella, one of the two Skylab 3 common cross spiders "Araneus diadematus," and the web it had spun in the zero-gravity of space aboard the Skylab space station cluster in Earth orbit. This picture was taken with a hand-held 35mm Nikon camera. During the 59-day Skylab 3 mission the two spiders, Arabella and Anita, were housed in an enclosure onto which a motion picture and a still camera were attempts to build a web in the weightless environment. The spider experiment (ED52) was one of 25 experiments selected for Skylab by NASA from more than 3,400 experiment proposals submitted by high school students throughout the nation. ED52 was submitted by 17-year-old Judith S. Miles of Lexington, Massachusetts. Anita died during the last week of the mission. Photo credit: NASA

Mass Measurement - Skylab Student Experiment ED-74

NASA Technical Reports Server (NTRS)

1973-01-01

Vincent W. Converse of Rockford, Illinois proposed Skylab's student experiment ED-74, Mass Measurement, to measure mass in a weightless environment. This chart describes Converse's experiment. Mass is the quantity of matter in any object. The gravitational force between an object and the Earth is called weight, which is a result of the Earth's gravity acting upon the object's mass. Even though objects in Skylab were apparently weightless, their mass properties were unchanged. Measurement of mass is therefore an acceptable alternative to measurement of weight. The devices used in this experiment provided accurate mass measurements of the astronauts' weights, intakes, and body wastes throughout the missions. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Report of 14-day bedrest simulation of Skylab

NASA Technical Reports Server (NTRS)

Johnson, P. C. (Compiler); Mitchell, C. (Compiler)

1976-01-01

Part one of a two-phase bedrest project in which the physiological effects of weightlessness were simulated is presented. The project was designed to approximate the medical testing and dietary control of Skylab. The test period included a three week pre-flight period, a two week bedrest period and a two week post-flight period. The test subjects ate measured amounts of the Skylab diet and drank deionized water to recreate the metabolic balance studies of Skylab. The medical testing program, pre- and postbedrest, was similar to that of Skylab including: lower body negative pressure testing the orthostatic intolerance noted after both spaceflights and bedrest, bicycle ergometry testing the cardiovascular response to graded exercise, postural equilibrium, vestibular studies and electromyograms. Fluid and electrolyte shifts and balance were documented with intake and output records and radionuclide studies. The subjects were observed by a psychiatrist who watched for signs of mental stress in the test environment and changes in mental status.

SKYLAB (SL) PRIME CREW - BLDG 5 - JSC

NASA Image and Video Library

1973-03-20

S73-20622 (March 1973) --- Scientist-astronaut Joseph P. Kerwin, science pilot of the first manned Skylab mission, demonstrates the Body Mass Measurement Experiment (M172) during Skylab training at the Johnson Space Center. Dr. Kerwin is in the work and experiments area of the crew quarters of the Skylab Orbital Workshop (OWS) trainer at JSC. The M172 experiment will demonstrate body mass measurement in a null gravity environment, validate theoretical behavior of this method, and support those medical experiments for which body mass measurements are required. The data to be collected in support of M172 are: preflight calibration of the body mass measurement device and measurements of known masses up to 100 kilograms (220 pounds) three times during each Skylab mission. The device, a spring/flexure pivot-mounted chair, will also be used for daily determination of the crewmen?s weight, which will be manually logged and voice recorded for subsequent telemetered transmission. Photo credit: NASA

Skylab

NASA Image and Video Library

1972-06-02

Downey, California high school student, Donald W. Shellack, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Shellack was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

North Rochester, New York high school student, Robert L. Staehle, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Staehle was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Littleton, Colorado high school student, Cheryl A. Peltz, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Peltz was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Bayport, New York high school student, James E. Healy, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Healy was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Berkley, Michigan high school student, Kirk M. Sherhart, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Sherhart was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Springfield, Massachusetts high school student, Gregory A. Merkel, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Merkel was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab Mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Youngstown, Ohio high school student, W. Brian Dunlap, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Dunlap was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Garland, Texas high school student, Keith D. McGee, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. McGee was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab Mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Atlanta, Georgia high school student, Neal W. Shannon, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Shannon was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Oshkosh, Wisconsin high school student, Joe B. Zmolek, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Zmolek was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Baton Rouge, Louisiana high school student, Joe W. Reihs, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Reihs was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Houston, Texas high school student, Kathy L. Jackson, is greeted by astronauts Russell L. Schweickart (left) and Owen K. Garriott (center), and Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew during a tour of the Marshall Space Flight Center (MSFC). Jackson was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1962-06-02

St. Paul, Minnesota high school student, Roger Johnston, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Johnston was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

West Point, Nebraska high school student, Joel C. Wordekemper, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Wordekemper was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Aiea, Hawaii high school student, John C. Hamilton, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Hamilton was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Westbury, New York high school student, Keith L.Stein , is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Stein was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Silverton, Oregon high school student, Daniel C. Bochsler, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Bochsler was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-05-02

Kent, Washinton high school student, Troy A. Crites, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Crites was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Biochemical and hematologic changes after short-term space flight

NASA Technical Reports Server (NTRS)

Leach, Carolyn S.

1991-01-01

Clinical laboratory data from blood samples obtained from astronauts before and after 28 flights (average duration = 6 days) of the Space Shuttle were analyzed by the paired t-test and the Wilcoxon signed-rank test and compared with data from the Skylab flights (duration = 28, 56, and 84 days). Angiotensin I and aldosterone were elevated immediately after short-term space flights, but the response of angiotensin I was delayed after Skylab flights. Serum calcium was not elevated after Shuttle flights, but magnesium and uric acid decreased after both Shuttle and Skylab. Creatine phosphokinase in serum was reduced after Shuttle but not Skylab flights, probably because exercises to prevent deconditioning were not performed on the Shuttle. Total cholesterol was unchanged after Shuttle flights, but low density lipoprotein cholesterol increased and high density lipoprotein cholesterol decreased. The concentration of red blood cells was elevated after Shuttle flights and reduced after Skylab flights.

Lineaments on Skylab photographs: Detection, mapping, and hydrologic significance in central Tennessee

NASA Technical Reports Server (NTRS)

Moore, G. K.

1976-01-01

An investigation was carried out to determine the feasibility of mapping lineaments on SKYLAB photographs of central Tennessee and to determine the hydrologic significance of these lineaments, particularly as concerns the occurrence and productivity of ground water. Sixty-nine percent more lineaments were found on SKYLAB photographs by stereo viewing than by projection viewing, but longer lineaments were detected by projection viewing. Most SKYLAB lineaments consisted of topographic depressions and they followed or paralleled the streams. The remainder were found by vegetation alinements and the straight sides of ridges. Test drilling showed that the median yield of wells located on SKYLAB lineaments were about six times the median yield of wells located by random drilling. The best single detection method, in terms of potential savings, was stereo viewing. Larger savings might be achieved by locating wells on lineaments detected by both stereo viewing and projection.

Similarities among receptor pockets and among compounds: analysis and application to in silico ligand screening.

PubMed

Fukunishi, Yoshifumi; Mikami, Yoshiaki; Nakamura, Haruki

2005-09-01

We developed a new method to evaluate the distances and similarities between receptor pockets or chemical compounds based on a multi-receptor versus multi-ligand docking affinity matrix. The receptors were classified by a cluster analysis based on calculations of the distance between receptor pockets. A set of low homologous receptors that bind a similar compound could be classified into one cluster. Based on this line of reasoning, we proposed a new in silico screening method. According to this method, compounds in a database were docked to multiple targets. The new docking score was a slightly modified version of the multiple active site correction (MASC) score. Receptors that were at a set distance from the target receptor were not included in the analysis, and the modified MASC scores were calculated for the selected receptors. The choice of the receptors is important to achieve a good screening result, and our clustering of receptors is useful to this purpose. This method was applied to the analysis of a set of 132 receptors and 132 compounds, and the results demonstrated that this method achieves a high hit ratio, as compared to that of a uniform sampling, using a receptor-ligand docking program, Sievgene, which was newly developed with a good docking performance yielding 50.8% of the reconstructed complexes at a distance of less than 2 A RMSD.

Analysis of metabolic energy utilization in the Skylab astronauts

NASA Technical Reports Server (NTRS)

Leonard, J. I.

1977-01-01

Skylab biomedical data regarding man's metabolic processes for extended periods of weightlessness is presented. The data was used in an integrated metabolic balance analysis which included analysis of Skylab water balance, electrolyte balance, evaporative water loss, and body composition. A theoretical analysis of energy utilization in man is presented. The results of the analysis are presented in tabular and graphic format.

SKYLAB (SL)-2 - TELEVISION (INFLIGHT)

NASA Image and Video Library

1973-05-27

S73-26776 (26 May 1973) --- An interior view of the Orbital Workshop of the Skylab 1 space station cluster in Earth orbit can be seen in this reproduction taken from a color television transmission made by a TV camera aboard the space station. Astronaut Charles Conrad Jr., Skylab 2 commander, is floating up through the hatch. Food lockers are in the foreground. Photo credit: NASA

SL3-111-01516

NASA Image and Video Library

1973-07-01

SL3-111-1516 (July-September 1973) --- Astronaut Alan L. Bean, Skylab 3 commander, uses a battery powered shaver in the crew quarters of the Orbital Workshop (OWS) aboard the Skylab space station cluster in Earth orbit. Astronaut Bean, Owen K. Garriott, science pilot, and Jack R. Lousma, pilot, went on to successfully complete 59 days aboard the Skylab cluster in Earth orbit. Photo credit: NASA

Skylab: Its anguish and triumph - A memoir

NASA Technical Reports Server (NTRS)

Von Puttkamer, J.

1982-01-01

During its ascent to earth orbit, Skylab, launched May 14, 1973, sustained severe damage due to the premature deployment of its micrometeoroid shield. In this paper, a participating engineer describes how a thermal shield repair concept was developed and appropriate hardware was built and tested within 11 days of the mishap, and how the repair concept was sucessfully implemented in space to rescue Skylab.

Skylab

NASA Image and Video Library

1973-01-01

This chart describes Skylab's Extreme Ultraviolet (XUV) Coronal Spectroheliograph, one of the eight Apollo Telescope Mount facilities. It was designed to sequentially photograph the solar chromosphere and corona in selected ultraviolet wavelengths . The instrument also obtained information about composition, temperature, energy conversion and transfer, and plasma processes of the chromosphere and lower corona. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Living and Working in Space: A History of Skylab.

ERIC Educational Resources Information Center

Compton, W. David; Benson, Charles D.

The history of the National Aeronautics and Space Administration Skylab program is provided in this three-part book. Part I (chapters 1 to 5) traces the origins of the Skylab concept from its emergence in the period 1962-65 through its evolution into final form in 1969. Part II (chapters 6 to 13) focuses on the period from 1969-73, considering the…

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows the Rotating Litter Chair, a major component of Skylab's Human Vestibular Function experiment (M131). The experiment was a set of medical studies designed to determine the effect of long-duration space missions on astronauts' coordination abilities. The M131 experiment tested the astronauts susceptibility to motion sickness in the Skylab environment, acquired data fundamental to an understanding of the functions of human gravity reception under prolonged absence of gravity, and tested for changes in the sensitivity of the semicircular canals. Data from this experiment was collected before, during, and after flight. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1973-05-01

This photograph was taken during testing of an emergency procedure to free jammed solar array panels on the Skylab workshop. A metal strap became tangled over one of the folded solar array panels when Skylab lost its micrometeoroid shield during the launch. This photograph shows astronauts Schweickart and Gibson in the Marshall Space Flight Center (MSFC) Neutral Buoyancy Simulator (NBS) using various cutting tools and methods developed by the MSFC to free the jammed solar wing. Extensive testing and many hours of practice in simulators such as the NBS tank helped prepare the Skylab crewmen for extravehicular performance in the weightless environment. This huge water tank simulated the weightless environment that the astronauts would encounter in space.

The Proceedings of the Skylab Life Sciences Symposium, volume 2

NASA Technical Reports Server (NTRS)

Johnston, R. S.; Dietlein, L. F.

1974-01-01

The three manned Skylab missions resulted in biomedical experiment data in the areas of neurophysiology, musculoskeletal physiology, biochemistry, hematology, cytology, cardiovascular and respiratory metabolic functions: as well as detailed test objectives involving crew health and environment procedures. Major emphasis was placed on results from the last mission, Skylab 4, which covered 84 days of in-flight data collection. Many new norms were defined for normal man living and operating in a unique environment. While man is quite adaptable to this unique environment, many of the changes observed in Skylab require additional research for future flights lasting very long periods of time such as a Mars mission requiring 18 months.

SkyLab (SL)-3 - Recovery

NASA Image and Video Library

1973-11-08

S73-36451 (25 Sept. 1973) --- The three crewmen of the Skylab 3 mission are seen aboard the prime recovery ship, USS New Orleans, following their successful 59-day visit to the Skylab space station in Earth orbit. They are, left to right, astronaut Jack R. Lousma, pilot; scientist-astronaut Owen K. Garriott, science pilot; and astronaut Alan L. Bean, commander. The Skylab 3 Command Module with the three crewmen aboard splashed down in the Pacific about 230 miles southwest of San Diego, California. They are seated atop a platform of a fork-lift dolly. Recovery support personnel are wearing face masks to prevent exposing the crewmen to disease. Photo credit: NASA

Skylab

NASA Image and Video Library

1972-08-21

Miss Cheryl Peltz, high school student from Littleton, Colorado, discusses her “Cytoplasmic Streaming in Zero Gravity” experiment with Ed Armstrong (left) of the NASA Manned Spacecraft Center, and her advisor Charles Cothran (right) of the NASA Marshall Space Flight Center (MSFC). She was one of the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab Mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment, of which Miss Peltz’s was one.

The Proceedings of the Skylab Life Sciences Symposium, Volume 1

NASA Technical Reports Server (NTRS)

Johnston, R. S.; Dietlein, L. F.

1974-01-01

The three manned Skylab missions resulted in biomedical experiment data in the areas of neurophysiology, musculoskeletal physiology, biochemistry, hematology, cytology, cardiovascular and respiratory metabolic functions: as well as detailed test objectives involving crew health and environment procedures. Major emphasis was placed on results from the last mission, Skylab 4, which covered 84 days of in-flight data collection. Many new norms were defined for normal man living and operating in a unique environment. While man is quite adaptable to this unique environment, many of the changes observed in Skylab require additional research for future flights lasting very long periods of time such as a Mars mission requiring 18 months.

Astronaut Robert Crippen holds training model of Skylab experiment

NASA Image and Video Library

1972-06-15

S72-43280 (15 June 1972) --- Astronaut Robert L. Crippen, Skylab Medical Experiment Altitude Test (SMEAT) commander, holds the training model of Skylab experiment T003, the aerosol analysis test, in this preview of SMEAT activity. He is part of a three-man SMEAT crew who will spend up to 56 days in the Crew Systems Division's 20-foot altitude chamber at the NASA Manned Spacecraft Center (MSC) beginning in mid-July to obtain medical data and evaluate medical experiment equipment for Skylab. The two crew members not shown in this view are astronauts Karol J. Bobko, SMEAT pilot, and Dr. William E. Thornton, SMEAT science pilot. Photo credit: NASA

Planning and management of science programs on Skylab

NASA Technical Reports Server (NTRS)

Parker, R. A. R.; Sevier, J. R.

1974-01-01

Discussion of the experience gained in experiment operation planning during the Skylab mission. The Skylab flight planning activity allowed the experimenters to interact with the system and provided the flexibility to respond to contingencies both major and minor. Both these aspects contributed to make efficient use of crew time thus helping to increase the science return from the mission. Examples of the need for real time scheduling response and of the tradeoffs considered between conflicting experiment requirements are presented. General management principles derived from this experience are developed. The Skylab mission experiences, together with previous Apollo mission experiences, are shown to provide a good background for Shuttle flight planning.

SKYLAB (SL) PRIME CREW - BLDG. 5 - JSC

NASA Image and Video Library

1973-03-20

S73-20695 (1 March 1973) --- Astronaut Charles Conrad Jr., commander of the first manned Skylab mission, checks out the Human Vestibular Function, Experiment M131, during Skylab training at Johnson Space Center. Conrad is in the work and experiments compartment of the crew quarters of the Skylab Orbital Workshop (OWS) trainer at JSC. The reference sphere with a magnetic rod is used by the astronaut to indicate body orientation non-visually. The litter chair in which he is seated can be rotated by a motor at its base or, when not being rotated, can tilt forward, backward or to either side. Photo credit: NASA

Lineaments on Skylab photographs: Detection, mapping, and hydrologic significance in central Tennessee

NASA Technical Reports Server (NTRS)

Moore, G. K. (Principal Investigator)

1976-01-01

The author has identified the following significant results. Lineaments were detected on Skylab photographs by stereo viewing, projection viewing, and composite viewing. Sixty-nine percent more lineaments were found by stereo viewing than by projection, but segments of projection lineaments are longer; total length of lineaments found by these two methods is nearly the same. Most Skylab lineaments consist of topographic depression: stream channel alinements, straight valley walls, elongated swales, and belts where sinkholes are abundant. Most of the remainder are vegetation alinements. Lineaments are most common in dissected areas having a thin soil cover. Results of test drilling show: (1) the median yield of test wells on Skylab lineaments is about six times the median yield of all existing wells; (2) three out of seven wells on Skylab lineaments yield more than 6.3 1/s (110 gal/min): (3) low yields are possible on lineaments as well as in other favorable locations; and (4) the largest well yields can be obtained at well locations of Skylab lineaments that also are favorably located with respect to topography and geologic structure, and are in the vicinity of wells with large yields.

Human and server docking prediction for CAPRI round 30-35 using LZerD with combined scoring functions.

PubMed

Peterson, Lenna X; Kim, Hyungrae; Esquivel-Rodriguez, Juan; Roy, Amitava; Han, Xusi; Shin, Woong-Hee; Zhang, Jian; Terashi, Genki; Lee, Matt; Kihara, Daisuke

2017-03-01

We report the performance of protein-protein docking predictions by our group for recent rounds of the Critical Assessment of Prediction of Interactions (CAPRI), a community-wide assessment of state-of-the-art docking methods. Our prediction procedure uses a protein-protein docking program named LZerD developed in our group. LZerD represents a protein surface with 3D Zernike descriptors (3DZD), which are based on a mathematical series expansion of a 3D function. The appropriate soft representation of protein surface with 3DZD makes the method more tolerant to conformational change of proteins upon docking, which adds an advantage for unbound docking. Docking was guided by interface residue prediction performed with BindML and cons-PPISP as well as literature information when available. The generated docking models were ranked by a combination of scoring functions, including PRESCO, which evaluates the native-likeness of residues' spatial environments in structure models. First, we discuss the overall performance of our group in the CAPRI prediction rounds and investigate the reasons for unsuccessful cases. Then, we examine the performance of several knowledge-based scoring functions and their combinations for ranking docking models. It was found that the quality of a pool of docking models generated by LZerD, that is whether or not the pool includes near-native models, can be predicted by the correlation of multiple scores. Although the current analysis used docking models generated by LZerD, findings on scoring functions are expected to be universally applicable to other docking methods. Proteins 2017; 85:513-527. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Skylab 2 Solar Physics Experiment

NASA Technical Reports Server (NTRS)

1973-01-01

Skylab 2 Solar Physics Experiment. This black and white view of a solar flare was taken from the skylab remote solar experiment module mounted on top of the vehicle and worked automatically without any interaction from the crew. Solar flares or sunspots are eruptions on the sun's surface and appear to occur in cycles. When these cycles occur, there is worldwide electromagnetic interference affecting radio and television transmission.

Astronaut Jack Lousma looks at map of Earth in ward room of Skylab cluster

NASA Image and Video Library

1973-08-01

S73-34193 (1 Aug. 1973) --- Astronaut Jack R. Lousma, Skylab 3 pilot, looks at a map of Earth at the food table in the ward room of the Orbital Workshop (OWS). In this photographic reproduction taken from a television transmission made by a color TV camera aboard the Skylab space station cluster in Earth orbit. Photo credit: NASA

Skylab medical experiments altitude test crew observations.

NASA Technical Reports Server (NTRS)

Bobko, K. J.

1973-01-01

The paper deals with the crew's observations during training and the SMEAT 56-day test. Topics covered include the crew's adaptation to the SMEAT environment and medical experiments protocol. Personal observations are made of daily activities surrounding the medical experiments hardware, Skylab clothing, supplementary activities, recreational equipment, food, and waste management. An assessment of these items and their contributions to the Skylab flight program is made.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows the flight unit for Skylab's White Light Coronagraph, an Apollo Telescope Mount (ATM) facility that photographed the solar corona in the visible light spectrum. A TV camera in the instrument provided real-time pictures of the occulted Sun to the astronauts at the control console and also transmitted the images to the ground. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

SL3-115-01837

NASA Image and Video Library

1973-08-01

SL3-115-1837 (August 1973) --- Astronaut Owen K. Garriott, Skylab 3 science pilot, retrieves an imagery experiment from the Apollo Telescope Mount (ATM) attached to the Skylab in Earth orbit. Garriott’s was a special extravehicular activity (EVA) to remove from the attached ATM/orbiting observatory magazines which will be returned to Earth when the second manning of the Skylab space station has been completed. Photo credit: NASA

Skylab consolidated instrumentation plan for SL-1/SL-2

NASA Technical Reports Server (NTRS)

Clark, D. E.

1972-01-01

The consolidated instrumentation plan is presented for employing optical and electronic data acquisition systems to monitor the performance and trajectory of Skylab 1 and Skylab 2 vehicles during the launch phase. Telemetry, optical, and electronic tracking equipment on board the vehicles, and data acquisition systems monitoring the flights are discussed. Flight safety instrumentation, vehicle data transmission systems, and instrumentation geography are also described.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows Skylab's Ultraviolet (UV) Airglow Horizon Photography experiment. It was an astrophysics investigation designed to photograph the twilight airflow and Earth's ozone layer simultaneously in visible and UV wavelengths. These observations provided information on oxygen, nitrogen, and ozone layers in the Earth's atmosphere, and on their variation during night and day cycles. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab communications carrier 16536G and filter bypass adapter assembly 12535G. [development of communications equipment for use with Skylab spacecraft

NASA Technical Reports Server (NTRS)

1974-01-01

Communications equipment for use with the Skylab project is examined to show compliance with contract requirements. The items of equipment considered are: (1) communications carrier assemblies, (2) filter bypass adapter assemblies, and (3) sub-assemblies, parts, and repairs. Additional information is provided concerning contract requirements, test requirements, and failure investigation actions.

Empirical entropic contributions in computational docking: evaluation in APS reductase complexes.

PubMed

Chang, Max W; Belew, Richard K; Carroll, Kate S; Olson, Arthur J; Goodsell, David S

2008-08-01

The results from reiterated docking experiments may be used to evaluate an empirical vibrational entropy of binding in ligand-protein complexes. We have tested several methods for evaluating the vibrational contribution to binding of 22 nucleotide analogues to the enzyme APS reductase. These include two cluster size methods that measure the probability of finding a particular conformation, a method that estimates the extent of the local energetic well by looking at the scatter of conformations within clustered results, and an RMSD-based method that uses the overall scatter and clustering of all conformations. We have also directly characterized the local energy landscape by randomly sampling around docked conformations. The simple cluster size method shows the best performance, improving the identification of correct conformations in multiple docking experiments. 2008 Wiley Periodicals, Inc.

Protein-Protein Docking with F2Dock 2.0 and GB-Rerank

PubMed Central

Chowdhury, Rezaul; Rasheed, Muhibur; Keidel, Donald; Moussalem, Maysam; Olson, Arthur; Sanner, Michel; Bajaj, Chandrajit

2013-01-01

Motivation Computational simulation of protein-protein docking can expedite the process of molecular modeling and drug discovery. This paper reports on our new F2 Dock protocol which improves the state of the art in initial stage rigid body exhaustive docking search, scoring and ranking by introducing improvements in the shape-complementarity and electrostatics affinity functions, a new knowledge-based interface propensity term with FFT formulation, a set of novel knowledge-based filters and finally a solvation energy (GBSA) based reranking technique. Our algorithms are based on highly efficient data structures including the dynamic packing grids and octrees which significantly speed up the computations and also provide guaranteed bounds on approximation error. Results The improved affinity functions show superior performance compared to their traditional counterparts in finding correct docking poses at higher ranks. We found that the new filters and the GBSA based reranking individually and in combination significantly improve the accuracy of docking predictions with only minor increase in computation time. We compared F2 Dock 2.0 with ZDock 3.0.2 and found improvements over it, specifically among 176 complexes in ZLab Benchmark 4.0, F2 Dock 2.0 finds a near-native solution as the top prediction for 22 complexes; where ZDock 3.0.2 does so for 13 complexes. F2 Dock 2.0 finds a near-native solution within the top 1000 predictions for 106 complexes as opposed to 104 complexes for ZDock 3.0.2. However, there are 17 and 15 complexes where F2 Dock 2.0 finds a solution but ZDock 3.0.2 does not and vice versa; which indicates that the two docking protocols can also complement each other. Availability The docking protocol has been implemented as a server with a graphical client (TexMol) which allows the user to manage multiple docking jobs, and visualize the docked poses and interfaces. Both the server and client are available for download. Server: http://www.cs.utexas.edu/~bajaj/cvc/software/f2dock.shtml. Client: http://www.cs.utexas.edu/~bajaj/cvc/software/f2dockclient.shtml. PMID:23483883

Skylab

NASA Image and Video Library

1972-01-01

This image depicts a layout of the Skylab workshop 1-G trainer crew quarters. At left, in the sleep compartment, astronauts slept strapped to the walls of cubicles and showered at the center. Next right was the waste management area where wastes were processed and disposed. Upper right was the wardroom where astronauts prepared their meals and foods were stored. In the experiment operation area, upper left, against the far wall, was the lower-body negative-pressure device (Skylab Experiment M092) and the Ergometer for the vectorcardiogram experiment (Skylab Experiment M063). The trainers and mockups were useful in the developmental phase, while engineers and astronauts were still working out optimum designs. They provided much data applicable to the manufacture of the flight articles.

Skylab

NASA Image and Video Library

1972-08-21

Todd Meister(center), high school student of the Bronx High School of Science, discusses his experiment “An Invitro Study of Selected Isolated Immune Phenomena” with his advisor, Dr. Robert Allen (right) and Henry Floyd, both of the Marshall Space Flight Center (MSFC). His experiment was aimed at discovering whether or not the absence of gravity affects the representative life processes. Meister was one of the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment.

Emblem - First (1st) Manned Skylab (SL) Mission

NASA Image and Video Library

1972-01-01

S72-52630 (February 1972) --- This is the emblem for the first manned Skylab mission. It will be a mission of up to 28 days. Skylab is an experimental space station consisting of a 100-ton laboratory complex in which medical, scientific and technological experiments will be performed in Earth orbit. The prime crew of this mission will be astronaut Charles Conrad Jr., commander; scientist-astronaut Joseph P. Kerwin, science pilot; and astronaut Paul J. Weits, pilot. The patch, designed by artist Kelly Freas, shows the Skylab silhouetted against the Earth's globe, which in turn is eclipsing the sun--showing the brilliant signet-ring pattern of the instant before the total eclipse. Photo credit: NASA

Skylab experiments. Volume 5: Astronomy and space physics. [Skylab observations of galactic radiation, solar energy, and interplanetary composition for high school level education

NASA Technical Reports Server (NTRS)

1973-01-01

The astronomy and space physics investigations conducted in the Skylab program include over 20 experiments in four categories to explore space phenomena that cannot be observed from earth. The categories of space research are as follows: (1) phenomena within the solar system, such as the effect of solar energy on Earth's atmosphere, the composition of interplanetary space, the possibility of an inner planet, and the X-ray radiation from Jupiter, (2) analysis of energetic particles such as cosmic rays and neutrons in the near-earth space, (3) stellar and galactic astronomy, and (4) self-induced environment surrounding the Skylab spacecraft.

The Skylab program - An overview

NASA Technical Reports Server (NTRS)

Disher, J. H.

1975-01-01

A brief survey is made of significant aspects of the Skylab missions, with emphasis on atmospheric control, electrical power, stabilization and attitude control, prevention of instrument contamination, habitability of the spacecraft, in-flight maintenance and repair, and crew training. Skylab, unlike previous manned spacecraft, had a two-gas atmosphere of oxygen and nitrogen. The station's 25-kW capability was the largest electrical system ever flown in space. Skylab was the first flight application of large control-moment gyroscopes for attitude control. The missions provided significant scientific data in the fields of solar physics, biomedicine, earth resources, and materials processing. Particularly important was the finding of no physical limitation to men's ability to work in space for long periods.

Geologic and mineral and water resources investigations in western Colorado, using Skylab EREP data

NASA Technical Reports Server (NTRS)

Lee, K. (Principal Investigator); Prost, G. L.; Knepper, D. H.; Sawatzky, D. L.; Huntley, D.; Weimer, R. J.

1975-01-01

The author has identified the following significant results. Skylab photographs are superior to ERTS images for photogeologic interpretation, primarily because of improved resolution. Lithologic contacts can be detected consistently better on Skylab S190A photos than on ERTS images. Color photos are best; red and green band photos are somewhat better than color-infrared photos; infrared band photos are worst. All major geologic structures can be recognized on Skylab imagery. Large folds, even those with very gentle flexures, can be mapped accurately and with confidence. Bedding attitudes of only a few degrees are recognized; vertical exaggeration factor is about 2.5X. Mineral deposits in central Colorado may be indicated on Skylab photos by lineaments and color anomalies, but positive identification of these features is not possible. S190A stereo color photography is adequate for defining drainage divides that in turn define the boundaries and distribution of ground water recharge and discharge areas within a basin.

Skylab

NASA Image and Video Library

1973-01-01

Judith S. Miles of Lexington High School, Lexington, Massachusetts, proposed skylab student experiment ED-52, Web Formation. This experiment was a study of a spider's behavior in a weightless environment. The geometrical structure of the web of the orb-weaving spider provides a good measure of the condition of its central nervous system. Since the spider senses its own weight to determine the required thickness of web material and uses both the wind and gravity to initiate construction of its web, the lack of gravitational force in Skylab provided a new and different stimulus to the spider's behavioral response. Two common cross spiders, Arabella and Anita, were used for the experiment aboard the Skylab-3 mission. After initial disoriented attempts, both spiders produced almost Earth-like webs once they had adapted to weightlessness. This photograph is of Arabella, a cross spider, in her initial attempt at spirning a web. This picture was taken by the crew of the Skylab 3 mission before Arabella adapted to her new environment.

Skylab

NASA Image and Video Library

1972-08-21

Lexington, Massachusetts high school student, Judith Miles, discusses her proposed Skylab experiment with Keith Demorest (right) and Henry Floyd, both of Marshall Space Flight Center (MSFC). In her experiment, called the “Web Formation in Zero Gravity”, called for spiders to be released into a box and their actions recorded to determine how well they adapt to the absence of gravity. Spiders are known to adapt quickly to other changes in the environment but nothing was known of their ability to adapt to weightlessness. At the same time spiders were weaving webs in Earth orbit, similar spiders were spinning webs in identical boxes on Earth under full gravity conditions. Miles was among the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab Mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment.

Web Formation - Skylab Student Experiment ED-52

NASA Technical Reports Server (NTRS)

1973-01-01

Judith S. Miles of Lexington High School, Lexington, Massachusetts, proposed skylab student experiment ED-52, Web Formation. This experiment was a study of a spider's behavior in a weightless environment. The geometrical structure of the web of the orb-weaving spider provides a good measure of the condition of its central nervous system. Since the spider senses its own weight to determine the required thickness of web material and uses both the wind and gravity to initiate construction of its web, the lack of gravitational force in Skylab provided a new and different stimulus to the spider's behavioral response. Two common cross spiders, Arabella and Anita, were used for the experiment aboard the Skylab-3 mission. After initial disoriented attempts, both spiders produced almost Earth-like webs once they had adapted to weightlessness. This photograph is of Arabella, a cross spider, in her initial attempt at spirning a web. This picture was taken by the crew of the Skylab 3 mission before Arabella adapted to her new environment.

Performance of solar shields. [Skylab 1 micrometeoroid shield difficulties

NASA Technical Reports Server (NTRS)

Schwinghamer, R. J.

1974-01-01

The loss of the micrometeoroid shield from the Orbital Workshop section of Skylab 1 about 63 seconds after lift-off, was the catalyst for a prodigious effort to develop a substitute for the passive portion of the thermal control system. An intensive effort is described in which numerous potential thermal shield materials were assessed, and during which period ten specific shield designs were developed and carried through various stages of development and test. Thermal shield materials data are discussed, including optical, strength, fatigue, outgassing, tackiness, ultraviolet radiation, and material memory properties. Specifically addressed are thermal shield materials selection criteria and the design, development, and test requirements associated with the successful development of Skylab thermal shields, and specifically the two thermal shields subsequently deployed over the exposed gold foil skin of the Orbital Workshop. Also considered are the general performance and thermal improvements provided by both the parasol design deployed by the Skylab 1 crew, and the sail design deployed by the Skylab 2 crew.

Skylab

NASA Image and Video Library

1972-06-02

Kirk M. Sherhart, high school student from Berkley, Michigan, discussed a his proposed Skylab experiment with Dr. Robert Head of the Marshall Space Flight Center (MSFC) during his visit to the center. The lunar surface scene in the background is one of many space exhibits at the Alabama Space and Rocket Center in nearby Huntsville, Alabama. Sherhart was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-05-02

Vincent W. Converse, high school student from Rockford, Illinois, discussed a mass measurement device he proposed for the Skylab mission with Dr. Robert Head of the Marshall Space Flight Center (MSFC) during his visit to the center. The lunar surface scene in the background is one of many space exhibits at the Alabama Space and Rocket Center in nearby Huntsville, Alabama. Converse was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Wreath for Bill Pogue Memorial

NASA Image and Video Library

2014-03-14

CAPE CANAVERAL, Fla. – NASA Kennedy Space Center Director Robert Cabana welcomes guests to the United States Astronaut Hall of Fame at the Kennedy Space Center Visitor Complex for a wreath laying ceremony to honor former NASA astronaut William R. Pogue. Col. Pogue, pilot on NASA's Skylab 4 mission in 1973-74, died March 3. He was 84 years old. Skylab 4 was the third and final manned visit to the Skylab orbital workshop, launched Nov. 16, 1973, and concluded Feb. 8, 1974. At 84 days, 1 hour and 15 minutes, Skylab 4 was the longest manned space flight to that date. Pogue was accompanied on the record-setting 34.5-million-mile flight by Commander Gerald P. Carr and science-pilot Dr. Edward G. Gibson. They conducted dozens of experiments and science demonstrations during their 1,214 orbits of Earth. Pogue logged 13 hours and 31 minutes in two spacewalks outside the orbital workshop. For more information, visit http://www.nasa.gov/content/skylab-4-pilot-william-pogue-dies. Photo credit: NASA/Kim Shiflett

Wreath for Bill Pogue Memorial

NASA Image and Video Library

2014-03-14

CAPE CANAVERAL, Fla. – The United States Astronaut Hall of Fame at the Kennedy Space Center Visitor Complex is the site for a wreath laying ceremony for former NASA astronaut William R. Pogue. Col. Pogue, pilot on NASA's Skylab 4 mission in 1973-74, died March 3. He was 84 years old. Skylab 4 was the third and final manned visit to the Skylab orbital workshop, launched Nov. 16, 1973, and concluded Feb. 8, 1974. At 84 days, 1 hour and 15 minutes, Skylab 4 was the longest manned space flight to that date. Pogue was accompanied on the record-setting 34.5-million-mile flight by Commander Gerald P. Carr and science-pilot Dr. Edward G. Gibson. They conducted dozens of experiments and science demonstrations during their 1,214 orbits of Earth. Pogue logged 13 hours and 31 minutes in two spacewalks outside the orbital workshop. For more information, visit http://www.nasa.gov/content/skylab-4-pilot-william-pogue-dies. Photo credit: NASA/Kim Shiflett

Wreath for Bill Pogue Memorial

NASA Image and Video Library

2014-03-14

CAPE CANAVERAL, Fla. – Former NASA astronaut Edward G. Gibson, Ph.D., remarks on his friendship with former NASA astronaut William R. Pogue during a wreath laying ceremony at the United States Astronaut Hall of Fame at the Kennedy Space Center Visitor Complex. Col. Pogue, pilot on NASA's Skylab 4 mission in 1973-74, died March 3. He was 84 years old. Skylab 4 was the third and final manned visit to the Skylab orbital workshop, launched Nov. 16, 1973, and concluded Feb. 8, 1974. At 84 days, 1 hour and 15 minutes, Skylab 4 was the longest manned space flight to that date. Pogue was accompanied on the record-setting 34.5-million-mile flight by Commander Gerald P. Carr and science-pilot Gibson. They conducted dozens of experiments and science demonstrations during their 1,214 orbits of Earth. Pogue logged 13 hours and 31 minutes in two spacewalks outside the orbital workshop. For more information, visit http://www.nasa.gov/content/skylab-4-pilot-william-pogue-dies. Photo credit: NASA/Kim Shiflett

Wreath for Bill Pogue Memorial

NASA Image and Video Library

2014-03-14

CAPE CANAVERAL, Fla. – A wreath is placed next to a photo of former NASA astronaut William R. Pogue during a ceremony to honor Pogue held at the United States Astronaut Hall of Fame at the Kennedy Space Center Visitor Complex. Col. Pogue, pilot on NASA's Skylab 4 mission in 1973-74, died March 3. He was 84 years old. Skylab 4 was the third and final manned visit to the Skylab orbital workshop, launched Nov. 16, 1973, and concluded Feb. 8, 1974. At 84 days, 1 hour and 15 minutes, Skylab 4 was the longest manned space flight to that date. Pogue was accompanied on the record-setting 34.5-million-mile flight by Commander Gerald P. Carr and science-pilot Dr. Edward G. Gibson. They conducted dozens of experiments and science demonstrations during their 1,214 orbits of Earth. Pogue logged 13 hours and 31 minutes in two spacewalks outside the orbital workshop. For more information, visit http://www.nasa.gov/content/skylab-4-pilot-william-pogue-dies. Photo credit: NASA/Kim Shiflett

Skylab program payload integration. Skylab film environmental effects

NASA Technical Reports Server (NTRS)

1975-01-01

The effects of the Skylab environments on the 22 types of film used for data recording on Skylab were evaluated. Environmental histories and sensitometric curves for 114 rolls of film used for this evaluation are presented. Photographic parameters evaluated in detail were film fogging of black and white films, changes in maximum density of color film, latent image fading, and changes in film sensitivity. Other photographic and film physical anomalies such as electrostatic exposure, emulsion cracking, and reciprocity failure were also documented. Results based upon comparison of film sensitometric data for flight film with ground control film and ground test film are presented independently for each film type. The study showed that photographic film fulfilled the requirements of the Skylab applications in which it was used. Environmental film degradation, although present on almost every roll, did not preclude recording sufficient data to meet experiment requirements for all film, except film type SC-5. Specific conclusions are provided in the areas of further analyses, tests, and developments.

Skylab

NASA Image and Video Library

1972-08-21

St. Paul Minnesota high school student, Roger Johnston (center), Gene Vacca (left) of NASA Headquarters, and Ann Whitaker of the Marshall Space Flight Center (MSFC) discuss the equipment to be used for the student’s experiment, “Capillary Action Studies in a State of Free Fall”, to be performed aboard the Skylab the following year. Johnston was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC two months earlier where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

Skylab

NASA Image and Video Library

1973-05-01

The Saturn V vehicle, carrying the unmarned orbital workshop for the Skylab-1 mission, lifted off successfully and all systems performed normally. Sixty-three seconds into the flight, engineers in the operation support and control center saw an unexpected telemetry indication that signalled that damages occurred on one solar array and the micrometeoroid shield during the launch. The micrometeoroid shield, a thin protective cylinder surrounding the workshop protecting it from tiny space particles and the sun's scorching heat, ripped loose from its position around the workshop. This caused the loss of one solar wing and jammed the other. Still unoccupied, the Skylab was stricken with the loss of the heat shield and sunlight beat mercilessly on the lab's sensitive skin. Internal temperatures soared, rendering the station uninhabitable, threatening foods, medicines, films, and experiments. This image, taken during a fly-around inspection by the Skylab-2 crew, shows the station's remaining solar panel jammed against its side. The Marshall Space Flight Center had a major role in developing the procedures to repair the damaged Skylab.

Wreath for Bill Pogue Memorial

NASA Image and Video Library

2014-03-14

CAPE CANAVERAL, Fla. – Former NASA astronaut Gerald P. Carr remarks on his friendship with former NASA astronaut William R. Pogue during a wreath laying ceremony at the United States Astronaut Hall of Fame at the Kennedy Space Center Visitor Complex. Col. Pogue, pilot on NASA's Skylab 4 mission in 1973-74, died March 3. He was 84 years old. Skylab 4 was the third and final manned visit to the Skylab orbital workshop, launched Nov. 16, 1973, and concluded Feb. 8, 1974. At 84 days, 1 hour and 15 minutes, Skylab 4 was the longest manned space flight to that date. Pogue was accompanied on the record-setting 34.5-million-mile flight by Commander Carr and science-pilot Dr. Edward G. Gibson. They conducted dozens of experiments and science demonstrations during their 1,214 orbits of Earth. Pogue logged 13 hours and 31 minutes in two spacewalks outside the orbital workshop. For more information, visit http://www.nasa.gov/content/skylab-4-pilot-william-pogue-dies. Photo credit: NASA/Kim Shiflett

Skylab/EREP application to ecological, geological and oceanographic investigations of Delaware Bay

NASA Technical Reports Server (NTRS)

Klemas, V. (Principal Investigator)

1974-01-01

The author has identified the following significant results. NASA's ERTS-1 satellite and Skylab-EREP have both provided imagery suitable for investigating coastal vegetation, land use, current circulation, water turbidity, waste disposal, and sea state. Based on high contrast targets, such as piers and breakwaters, the ERTS-1 MSS seems to have a resolution of 70-100 meters, Skylab's S190A about 30-70 meters, and its S190B about 10-30 meters. Important coastal land use details can be more readily mapped using Skylab's imagery. On the other hand, the regular eighteen day cycle of ERTS-1 allows observation of important man-made and natural changes, and facilitates collection of ground truth. The Skylab/EREP multispectral scanner offers 13 spectral bands as compared to 4 bands on ERTS-1. However, EREP scanner tapes require special filtering to remove several types of noise and their conical line scan pattern must be linearized before small targets can be identified based on spatial features.

Applications of Skylab EREP photographs to mapping landforms and environmental geomorphology in the Great Plains and Midwest

NASA Technical Reports Server (NTRS)

Morrison, R. B.; Lineback, J. A.; Fuller, H. K.; Rinkenberger, R. K.

1975-01-01

The following evaluations of Skylab photographs were undertaken: (1) the 1290 Skylab S190A and S190B photographs of Illinois, Iowa, Kansas, Missouri, Nebraska, and South Dakota were evaluated in detail in terms of coverage, cloud cover, photographic quality, endlap, detectability of roads and stereorelief, and utility for geomorphologic mapping, and (2) the utility of the Skylab photos were tested for interpretive analytic mapping of geomorphologic features over large areas representative of different parts of this region. Photointerpretative maps of analytic geomorphology were obtained for various test areas representative of the varied landscapes in the region. These maps are useful for regional land-use planning, ground-water exploration, and other environmental geomorphologic-geologic applications. Compared with LANDSAT-1 MSS images, Skylab photos afford almost as extensive overviews of large areas but in considerably greater detail, and for many SL photos, moderate stereorelief. However, repetitive multiseasonal, cloud-free coverage by high-quality photos is very limited and many areas have no coverage at all.

Low Impact Docking System (LIDS)

NASA Technical Reports Server (NTRS)

LaBauve, Tobie E.

2009-01-01

Since 1996, NASA has been developing a docking system that will simplify operations and reduce risks associated with mating spacecraft. This effort has focused on developing and testing an original, reconfigurable, active, closed-loop, force-feedback controlled docking system using modern technologies. The primary objective of this effort has been to design a docking interface that is tunable to the unique performance requirements for all types of mating operations (i.e. docking and berthing, autonomous and piloted rendezvous, and in-space assembly of vehicles, modules and structures). The docking system must also support the transfer of crew, cargo, power, fluid, and data. As a result of the past 10 years of docking system advancement, the Low Impact Docking System or LIDS was developed. The current LIDS design incorporates the lessons learned and development experiences from both previous and existing docking systems. LIDS feasibility was established through multiple iterations of prototype hardware development and testing. Benefits of LIDS include safe, low impact mating operations, more effective and flexible mission implementation with an anytime/anywhere mating capability, system level redundancy, and a more affordable and sustainable mission architecture with reduced mission and life cycle costs. In 1996 the LIDS project, then known as the Advanced Docking Berthing System (ADBS) project, launched a four year developmental period. At the end of the four years, the team had built a prototype of the soft-capture hardware and verified the control system that will be used to control the soft-capture system. In 2001, the LIDS team was tasked to work with the X- 38 Crew Return Vehicle (CRV) project and build its first Engineering Development Unit (EDU).

Mapping multiple potential ATP binding sites on the matrix side of the bovine ADP/ATP carrier by the combined use of MD simulation and docking.

PubMed

Di Marino, Daniele; Oteri, Francesco; della Rocca, Blasco Morozzo; D'Annessa, Ilda; Falconi, Mattia

2012-06-01

The mitochondrial adenosine diphosphate/adenosine triphosphate (ADP/ATP) carrier-AAC-was crystallized in complex with its specific inhibitor carboxyatractyloside (CATR). The protein consists of a six-transmembrane helix bundle that defines the nucleotide translocation pathway, which is closed towards the matrix side due to sharp kinks in the odd-numbered helices. In this paper, we describe the interaction between the matrix side of the AAC transporter and the ATP(4-) molecule using carrier structures obtained through classical molecular dynamics simulation (MD) and a protein-ligand docking procedure. Fifteen structures were extracted from a previously published MD trajectory through clustering analysis, and 50 docking runs were carried out for each carrier conformation, for a total of 750 runs ("MD docking"). The results were compared to those from 750 docking runs performed on the X-ray structure ("X docking"). The docking procedure indicated the presence of a single interaction site in the X-ray structure that was conserved in the structures extracted from the MD trajectory. MD docking showed the presence of a second binding site that was not found in the X docking. The interaction strategy between the AAC transporter and the ATP(4-) molecule was analyzed by investigating the composition and 3D arrangement of the interaction pockets, together with the orientations of the substrate inside them. A relationship between sequence repeats and the ATP(4-) binding sites in the AAC carrier structure is proposed.

Evaluation of protein docking predictions using Hex 3.1 in CAPRI rounds 1 and 2.

PubMed

Ritchie, David W

2003-07-01

This article describes and reviews our efforts using Hex 3.1 to predict the docking modes of the seven target protein-protein complexes presented in the CAPRI (Critical Assessment of Predicted Interactions) blind docking trial. For each target, the structure of at least one of the docking partners was given in its unbound form, and several of the targets involved large multimeric structures (e.g., Lactobacillus HPr kinase, hemagglutinin, bovine rotavirus VP6). Here we describe several enhancements to our original spherical polar Fourier docking correlation algorithm. For example, a novel surface sphere smothering algorithm is introduced to generate multiple local coordinate systems around the surface of a large receptor molecule, which may be used to define a small number of initial ligand-docking orientations distributed over the receptor surface. High-resolution spherical polar docking correlations are performed over the resulting receptor surface patches, and candidate docking solutions are refined by using a novel soft molecular mechanics energy minimization procedure. Overall, this approach identified two good solutions at rank 5 or less for two of the seven CAPRI complexes. Subsequent analysis of our results shows that Hex 3.1 is able to place good solutions within a list of

Development of Skylab environmental protection for photographic film

NASA Technical Reports Server (NTRS)

Askew, W. C.; Clarke, W. A.; Best, C. A.

1971-01-01

The problems of providing adequate environmental protection for photographic film on three Skylab missions and the technical and management approach to resolving these problems are presented. The radiation, temperature, and humidity environments to which film will be exposed for up to 230 days in space and the effects of these environments on film are discussed. The report concludes with a definition of the design requirements for the Skylab film repository.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows equipment for the Skylab's Sleep Monitoring Experiment (M133), a medical evaluation designed to objectively determine the amount and quality of crewmembers' inflight sleep. The experiment monitored and recorded electroencephalographic (EEG) and electrooculographic (EOG) activity during astronauts' sleep periods. One of the astronauts was selected for this experiment and wore a fitted cap during his sleep periods. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Experimenters' reference based upon Skylab experiment management

NASA Technical Reports Server (NTRS)

1974-01-01

The methods and techniques for experiment development and integration that evolved during the Skylab Program are described to facilitate transferring this experience to experimenters in future manned space programs. Management responsibilities and the sequential process of experiment evolution from initial concept through definition, development, integration, operation and postflight analysis are outlined and amplified, as appropriate. Emphasis is placed on specific lessons learned on Skylab that are worthy of consideration by future programs.

The Final Skylab Mission: Man at Home and at Work in Space

NASA Technical Reports Server (NTRS)

1974-01-01

The accomplishments of the Skylab 4 mission are discussed. The medical experiments and dietary aspects of the mission are reported. The observation of the Comet Kohoutek is described. The remote sensing of earth resources is examined to show the areas of coverage. The repair of the space station and the accomplishment of unscheduled requirements are discussed. Statistical data of all the Skylab missions are tabulated.

Skylab

NASA Image and Video Library

1971-04-01

This photograph shows Skylab's Extreme Ultraviolet (XUV) Spectroheliograph during an acceptance test and checkout procedures in April 1971. The unit was an Apollo Telescope Mount (ATM) instrument designed to sequentially photograph the solar chromosphere and corona in selected ultraviolet wavelengths. The instrument also obtained information about composition, temperature, energy conversion and transfer, and plasma processes of the chromosphere and lower corona. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab study of water quality. [Kansas

NASA Technical Reports Server (NTRS)

Yarger, H. L. (Principal Investigator); Mccauley, J. R.

1975-01-01

The author has identified the following significant results. Apparent reflectance levels in the Skylab S190A and S192 bands, from one pass over three Kansas reservoirs, exhibit good statistical correlation with suspended solids. Band ratios appear to yield the best results. The concentration of suspended solids, mostly inorganic sediment, has the most effect on the reflected energy. Dissolved solids concentrations up to 200 ppm were not detectable by the Skylab sensors.

Astronaut Alan Bean reads data from book while holding teleprinter tape

NASA Technical Reports Server (NTRS)

1973-01-01

Astronaut Alan L. Bean, Skylab 3 commander, reads data from book in his right hand while holding teleprinter tape in his left hand, in the ward room of the Skylab space station's Orbital Workshop (OWS) crew quarters. This photograph was taken with a 35mm Nikon camera held by one of Bean's fellow crewmen during the 56.5 day second manned Skylab mission in Earth orbit.

Skylab

NASA Image and Video Library

1973-01-01

Pictures 1 and 2 show samples of Bacillus Subtillus grown during the first performance of Robert Staehle's experiment (ED-31) aboard Skylab. Pictures 3 and 4 show colonies of the same bacteria that developed during the second performance of the experiment. The experiment ED-31 was proposed by Robert L. Staehle of Rochester, New York to determine the effect of the Skylab environment (particularly weightlessness) on the survival, growth rates, and mutations of certain bacteria and spores.

An evaluation of the ATM man/machine interface. Phase 3: Analysis of SL-3 and SL-4 data

NASA Technical Reports Server (NTRS)

Bathurst, J. R., Jr.; Pain, R. F.; Ludewig, D. B.

1974-01-01

The functional adequacy of human factored crew operated systems under operational zero-gravity conditions is considered. Skylab ATM experiment operations generated sufficient telemetry and voice transcript data to support such an assessment effort. Discussions are presented pertaining to the methodology and procedures used to evaluate the hardware, training and directive aspects of Skylab 3 and Skylab 4 manned ATM experiment operations.

Skylab astronaut life support assembly

NASA Technical Reports Server (NTRS)

Brown, J. T.

1972-01-01

A comparative study was performed to define an optimum portable life support system for suited operations inside and outside the Skylab Program. Emphasis was placed on utilization of qualified equipment, modified versions of qualified equipment, and new systems made up to state-of-the-art components. Outlined are the mission constraints, operational modes, and evaluation ground rules by which the Skylab portable life support system was selected and the resulting design.

SKYLAB (SL)-4 - TELEVISION (APOLLO TELESCOPE MOUNT [ATM])

NASA Image and Video Library

1974-01-18

S74-15696 (1974) --- The solar disk photographed through the Skylab S082 Ultraviolet Spectrograph/Heliograph can be seen in this reproduction taken from a television tranmission made by a TV camera aboard the Skylab space station in Earth orbit. The S082 experiment is located in the Apollo Telescope Mount. This spectroheliogram shows specific emission features greatly enhanced over photographs of the solar disk in white light. Photo credit: NASA

The medical story. [of Skylab

NASA Technical Reports Server (NTRS)

Johnston, R. S.; Dietlein, L. F.; Michel, E. L.

1975-01-01

The paper discusses the medical program of the Skylab missions. The major medical systems discussed include the food system, the waste-management system, the personal-hygiene system, and the inflight medical support system. The life-sciences experiments conducted on Skylab are reviewed. These dealt with the cardiovascular system, mineral balance and bioassay of fluids, sleep, blood, metabolic activity, vestibular function, and time and motion studies. The medical operations were accomplished with only minor problems.

Saturn Apollo Program

NASA Image and Video Library

1975-07-01

SA-210 Apollo-Soyuz Test Project (ASTP) awaits the launch scheduled on July 15, 1975 on the launch pad at the Kennedy Space Center, the ASTP mission with astronauts Thomas Stafford, Vance Brand, and Donald "Deke" Slayton. The Saturn IB, developed under the direction of the Marshall Space Flight Center (MSFC), launched five manned Earth-orbital missions between 1968 and 1975: Apollo 7, Skylab 2, Skylab 3, Skylab 4, and the Apollo-Soyuz Test Project .

View of Arabella, one of the two Skylab 3 spiders used in experiment

NASA Image and Video Library

1973-08-08

S73-34206 (8 Aug. 1973) --- A closeup view of Arabella, one of two Skylab 3 common cross spiders ?Araneus diadematus,? and the web it had spun in the zero-gravity of space aboard the Skylab space station cluster in Earth orbit. This is a photographic reproduction made a color television transmission aboard Skylab. During the 59-day Skylab 3 mission the two spiders, Arabella and Anita, were housed in an enclosure onto which a motion picture camera and a still camera were attached to record the spiders? attempts to build a web in the weightless environment. The spider experiment (ED52) was one of 25 experiments selected for Skylab by NASA from more than 3,400 experiment proposals submitted by 17-year-old Judith S. Miles of Lexington, Massachusetts. Anita died during the last week of the mission. THIS PHOTOGRAPH IS A GOVERNMENT PUBLICATION ?NOT SUBJECT TO COPYRIGHT. It may not be used to state or imply the endorsement by NASA or by any NASA employee of a commercial product, process or service, or used in any way that might mislead. Accordingly, it is requested that if this photograph is used in advertising and other commercial promotions, layout and copy be submitted to NASA prior to release. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

The rate of neutron flow is commonly referred to as a flux. The measurement of neutron fluxes in Skylab was the subject of a proposal by Terry Quist of San Antonio, Texas. This chart describes Quist's experiment, Neutron Analysis, Skylab student experiment ED-76. These measurements were considered important not only by NASA but also by the scientific community for four reasons. High energy neutrons can be harmful to human tissue if they are present in significant quantities. Fluxes of neutrons can damage film and other sensitive experimental equipment in a marner similar to those produced by x-rays or other radiation. Furthermore, neutron fluxes can be used as a calibration source for other space-oriented particle physics experiments. Finally, neutron fluxes can affect sensitive x-ray and gamma-ray astronomy observations. Quist's objectives were to measure the neutron fluxes present in Skylab and, with the assistance of NASA and other physicists, to attempt determination of their origin as well as their energy range or spectrum. This experiment had stimulated interest in further studies of neutron phenomena in space. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Neutron Analysis - Skylab Student Experiment ED-76

NASA Technical Reports Server (NTRS)

1973-01-01

The rate of neutron flow is commonly referred to as a flux. The measurement of neutron fluxes in Skylab was the subject of a proposal by Terry Quist of San Antonio, Texas. This chart describes Quist's experiment, Neutron Analysis, Skylab student experiment ED-76. These measurements were considered important not only by NASA but also by the scientific community for four reasons. High energy neutrons can be harmful to human tissue if they are present in significant quantities. Fluxes of neutrons can damage film and other sensitive experimental equipment in a marner similar to those produced by x-rays or other radiation. Furthermore, neutron fluxes can be used as a calibration source for other space-oriented particle physics experiments. Finally, neutron fluxes can affect sensitive x-ray and gamma-ray astronomy observations. Quist's objectives were to measure the neutron fluxes present in Skylab and, with the assistance of NASA and other physicists, to attempt determination of their origin as well as their energy range or spectrum. This experiment had stimulated interest in further studies of neutron phenomena in space. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Computer-aided analysis of Skylab multispectral scanner data in mountainous terrain for land use, forestry, water resource, and geologic applications

NASA Technical Reports Server (NTRS)

Hoffer, R. M. (Principal Investigator)

1975-01-01

The author has identified the following significant results. One of the most significant results of this Skylab research involved the geometric correction and overlay of the Skylab multispectral scanner data with the LANDSAT multispectral scanner data, and also with a set of topographic data, including elevation, slope, and aspect. The Skylab S192 multispectral scanner data had distinct differences in noise level of the data in the various wavelength bands. Results of the temporal evaluation of the SL-2 and SL-3 photography were found to be particularly important for proper interpretation of the computer-aided analysis of the SL-2 and SL-3 multispectral scanner data. There was a quality problem involving the ringing effect introduced by digital filtering. The modified clustering technique was found valuable when working with multispectral scanner data involving many wavelength bands and covering large geographic areas. Analysis of the SL-2 scanner data involved classification of major cover types and also forest cover types. Comparison of the results obtained wth Skylab MSS data and LANDSAT MSS data indicated that the improved spectral resolution of the Skylab scanner system enabled a higher classification accuracy to be obtained for forest cover types, although the classification performance for major cover types was not significantly different.

Docking and scoring protein interactions: CAPRI 2009.

PubMed

Lensink, Marc F; Wodak, Shoshana J

2010-11-15

Protein docking algorithms are assessed by evaluating blind predictions performed during 2007-2009 in Rounds 13-19 of the community-wide experiment on critical assessment of predicted interactions (CAPRI). We evaluated the ability of these algorithms to sample docking poses and to single out specific association modes in 14 targets, representing 11 distinct protein complexes. These complexes play important biological roles in RNA maturation, G-protein signal processing, and enzyme inhibition and function. One target involved protein-RNA interactions not previously considered in CAPRI, several others were hetero-oligomers, or featured multiple interfaces between the same protein pair. For most targets, predictions started from the experimentally determined structures of the free (unbound) components, or from models built from known structures of related or similar proteins. To succeed they therefore needed to account for conformational changes and model inaccuracies. In total, 64 groups and 12 web-servers submitted docking predictions of which 4420 were evaluated. Overall our assessment reveals that 67% of the groups, more than ever before, produced acceptable models or better for at least one target, with many groups submitting multiple high- and medium-accuracy models for two to six targets. Forty-one groups including four web-servers participated in the scoring experiment with 1296 evaluated models. Scoring predictions also show signs of progress evidenced from the large proportion of correct models submitted. But singling out the best models remains a challenge, which also adversely affects the ability to correctly rank docking models. With the increased interest in translating abstract protein interaction networks into realistic models of protein assemblies, the growing CAPRI community is actively developing more efficient and reliable docking and scoring methods for everyone to use. © 2010 Wiley-Liss, Inc.

Blind predictions of protein interfaces by docking calculations in CAPRI.

PubMed

Lensink, Marc F; Wodak, Shoshana J

2010-11-15

Reliable prediction of the amino acid residues involved in protein-protein interfaces can provide valuable insight into protein function, and inform mutagenesis studies, and drug design applications. A fast-growing number of methods are being proposed for predicting protein interfaces, using structural information, energetic criteria, or sequence conservation or by integrating multiple criteria and approaches. Overall however, their performance remains limited, especially when applied to nonobligate protein complexes, where the individual components are also stable on their own. Here, we evaluate interface predictions derived from protein-protein docking calculations. To this end we measure the overlap between the interfaces in models of protein complexes submitted by 76 participants in CAPRI (Critical Assessment of Predicted Interactions) and those of 46 observed interfaces in 20 CAPRI targets corresponding to nonobligate complexes. Our evaluation considers multiple models for each target interface, submitted by different participants, using a variety of docking methods. Although this results in a substantial variability in the prediction performance across participants and targets, clear trends emerge. Docking methods that perform best in our evaluation predict interfaces with average recall and precision levels of about 60%, for a small majority (60%) of the analyzed interfaces. These levels are significantly higher than those obtained for nonobligate complexes by most extant interface prediction methods. We find furthermore that a sizable fraction (24%) of the interfaces in models ranked as incorrect in the CAPRI assessment are actually correctly predicted (recall and precision ≥50%), and that these models contribute to 70% of the correct docking-based interface predictions overall. Our analysis proves that docking methods are much more successful in identifying interfaces than in predicting complexes, and suggests that these methods have an excellent potential of addressing the interface prediction challenge. © 2010 Wiley-Liss, Inc.

AnchorDock for Blind Flexible Docking of Peptides to Proteins.

PubMed

Slutzki, Michal; Ben-Shimon, Avraham; Niv, Masha Y

2017-01-01

Due to increasing interest in peptides as signaling modulators and drug candidates, several methods for peptide docking to their target proteins are under active development. The "blind" docking problem, where the peptide-binding site on the protein surface is unknown, presents one of the current challenges in the field. AnchorDock protocol was developed by Ben-Shimon and Niv to address this challenge.This protocol narrows the docking search to the most relevant parts of the conformational space. This is achieved by pre-folding the free peptide and by computationally detecting anchoring spots on the surface of the unbound protein. Multiple flexible simulated annealing molecular dynamics (SAMD) simulations are subsequently carried out, starting from pre-folded peptide conformations, constrained to the various precomputed anchoring spots.Here, AnchorDock is demonstrated using two known protein-peptide complexes. A PDZ-peptide complex provides a relatively easy case due to the relatively small size of the protein, and a typical peptide conformation and binding region; a more challenging example is a complex between USP7 N-term and a p53-derived peptide, where the protein is larger, and the peptide conformation and a binding site are generally assumed to be unknown. AnchorDock returned native-like solutions ranked first and third for the PDZ and USP7 complexes, respectively. We describe the procedure step by step and discuss possible modifications where applicable.

wFReDoW: A Cloud-Based Web Environment to Handle Molecular Docking Simulations of a Fully Flexible Receptor Model

PubMed Central

De Paris, Renata; Frantz, Fábio A.; Norberto de Souza, Osmar; Ruiz, Duncan D. A.

2013-01-01

Molecular docking simulations of fully flexible protein receptor (FFR) models are coming of age. In our studies, an FFR model is represented by a series of different conformations derived from a molecular dynamic simulation trajectory of the receptor. For each conformation in the FFR model, a docking simulation is executed and analyzed. An important challenge is to perform virtual screening of millions of ligands using an FFR model in a sequential mode since it can become computationally very demanding. In this paper, we propose a cloud-based web environment, called web Flexible Receptor Docking Workflow (wFReDoW), which reduces the CPU time in the molecular docking simulations of FFR models to small molecules. It is based on the new workflow data pattern called self-adaptive multiple instances (P-SaMIs) and on a middleware built on Amazon EC2 instances. P-SaMI reduces the number of molecular docking simulations while the middleware speeds up the docking experiments using a High Performance Computing (HPC) environment on the cloud. The experimental results show a reduction in the total elapsed time of docking experiments and the quality of the new reduced receptor models produced by discarding the nonpromising conformations from an FFR model ruled by the P-SaMI data pattern. PMID:23691504

Boring crustaceans damage polystyrene floats under docks polluting marine waters with microplastic.

PubMed

Davidson, Timothy M

2012-09-01

Boring isopods damage expanded polystyrene floats under docks and, in the process, expel copious numbers of microplastic particles. This paper describes the impacts of boring isopods in aquaculture facilities and docks, quantifies and discusses the implications of these microplastics, and tests if an alternate foam type prevents boring. Floats from aquaculture facilities and docks were heavily damaged by thousands of isopods and their burrows. Multiple sites in Asia, Australia, Panama, and the USA exhibited evidence of isopod damage. One isopod creates thousands of microplastic particles when excavating a burrow; colonies can expel millions of particles. Microplastics similar in size to these particles may facilitate the spread of non-native species or be ingested by organisms causing physical or toxicological harm. Extruded polystyrene inhibited boring, suggesting this foam may prevent damage in the field. These results reveal boring isopods cause widespread damage to docks and are a novel source of microplastic pollution. Copyright © 2012 Elsevier Ltd. All rights reserved.

Skylab fluid mechanics simulations: Oscillation, rotation, collision and coalescence of water droplets under low-gravity environment

NASA Technical Reports Server (NTRS)

Vaughan, O. H., Jr.; Hung, R. J.

1975-01-01

Skylab 4 crew members performed a series of demonstrations showing the oscillations, rotations, as well as collision coalescence of water droplets which simulate various physical models of fluids under low gravity environment. The results from Skylab demonstrations provide information and illustrate the potential of an orbiting space-oriented research laboratory for the study of more sophisticated fluid mechanic experiments. Experiments and results are discussed.

Polarization of the zodiacal light - First results from Skylab

NASA Technical Reports Server (NTRS)

Sparrow, J. G.; Weinberg, J. L.; Hahn, R. C.

1976-01-01

A brief description is given of the Skylab ten color photoelectric photometer and the programs of measurements made during Skylab missions SL-2 and SL-3. Results obtained on the polarized brightness of zodiacal light at five points on the antisolar hemisphere are discussed and compared with other published data for the north celestial pole, south ecliptic pole, at elongation 90 degrees on the ecliptic, and at two places near the north galactic pole.

Task and work performance on Skylab missions 2, 3, and 4: Time and motion study: Experiment M151

NASA Technical Reports Server (NTRS)

Kubis, J. F.; Mclaughlin, E. J.; Jackson, J. M.; Rusnak, R.; Mcbride, G. H.; Saxon, S. V.

1977-01-01

Human task performance was evaluated under weightlessness conditions during long duration space flight in order to study the characteristics of the adaptation function. Results show that despite pronounced variability in training schedules and in initial reaction to the Skylab environment, in-flight task performance was relatively equivalent among Skylab crews, and behavioral performance continued to improve from beginning to end of all missions.

Skylab 3 crewmen shown eating in Orbital Workshop wardroom

NASA Technical Reports Server (NTRS)

1973-01-01

The three Skylab 3 crewmen are shown eating in the Orbital Workshop (OWS) wardroom of the Skylab space station in Earth orbit, in this photographic reproduction taken from a television transmission made by a color TV camera aboard the OWS. Astronaut Alan L. Bean (right), commander, illustrates eating under zero gravity conditions upsidedown. The two other crewmen are Scientist-Astronaut Owen K. Garriott (left), science pilot; and Astronaut Jack R. Lousma, pilot.

Probability of illness definition for the Skylab flight crew health stabilization program

NASA Technical Reports Server (NTRS)

1974-01-01

Management and analysis of crew and environmental microbiological data from SMEAT and Skylab are discussed. Samples were collected from ten different body sites on each SMEAT and Skylab crew-member on approximately 50 occasions and since several different organisms could be isolated from each sample, several thousand lab reports were generated. These lab reports were coded and entered in a computer file and from the file various tabular summaries were constructed.

Skylab vectorcardiograph: System description and in flight operation

NASA Technical Reports Server (NTRS)

Lintott, J.; Costello, M. J.

1975-01-01

A vectorcardiograph system was used to measure cardiac electrical activity of Skylab crewmen. This system was chosen because of its data-quantification advantages. The vectorcardiograph was required to meet recommended American Heart Association specifications, to withstand space environmental extremes, and to facilitate data gathering in the weightless environment. The vectorcardiograph system performed without failure, and all projected data were acquired. The appendix lists the design specifications used for the Skylab vectorcardiograph system.

Astronaut Joseph Kerwin takes blood sample from Astronaut Charles Conrad

NASA Technical Reports Server (NTRS)

1973-01-01

Scientist-Astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from Astronaut Charles Conrad Jr., Sylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series.

MSFC Skylab experimenter's reference

NASA Technical Reports Server (NTRS)

1974-01-01

The methods and techniques for experiment development and integration that evolved during the Skylab Program are described to facilitate transferring this experience to experimenters in future manned space programs. Management responsibilities and the sequential process of experiment evolution from initial concept through definition, development, integration, operation and postflight analysis are outlined in the main text and amplified, as appropriate, in appendixes. Emphasis is placed on specific lessons learned on Skylab that are worthy of consideration by future programs.

Astronauts Conrad and Kerwin - Human Vestibular Function Experiment - JSC

NASA Image and Video Library

1973-01-01

S73-20678 (1 March 1973) --- Astronaut Charles Conrad Jr., commander of the first manned Skylab mission, checks out the Human Vestibular Function, Experiment M131, during Skylab training at Johnson Space Center. Scientist-astronaut Joseph P. Kerwin, science pilot of the mission, goes over a checklist. The two men are in the work and experiments compartment of the crew quarters of the Skylab Orbital Workshop (OWS) trainer at JSC. Photo credit: NASA

Skylab materials processing facility experiment developer's report

NASA Technical Reports Server (NTRS)

Parks, P. G.

1975-01-01

The development of the Skylab M512 Materials Processing Facility is traced from the design of a portable, self-contained electron beam welding system for terrestrial applications to the highly complex experiment system ultimately developed for three Skylab missions. The M512 experiment facility was designed to support six in-space experiments intended to explore the advantages of manufacturing materials in the near-zero-gravity environment of Earth orbit. Detailed descriptions of the M512 facility and related experiment hardware are provided, with discussions of hardware verification and man-machine interfaces included. An analysis of the operation of the facility and experiments during the three Skylab missions is presented, including discussions of the hardware performance, anomalies, and data returned to earth.

An analysis and comparison of LANDSAT-1, Skylab (S-192) and aircraft data for delineation of land-water cover types of the Green Swamp, Florida

NASA Technical Reports Server (NTRS)

Higer, A. L. (Principal Investigator); Coker, A. E.; Schmidt, N. F.; Reed, I. E.

1975-01-01

The author has identified the following significant results. LANDSAT 1 and Skylab (S192) data from the Green Swamp area of central Florida were categorized into five classes: water, cypress, other wetlands, pine, and pasture. These categories were compared with similar categories on a detailed vegetative map made using low altitude aerial photography. Agreement of LANDSAT and Skylab categorized data with the vegetation map was 87 percent and 83 percent respectively. The Green Swamp vegetative categories may be widespread but often consist of numerous small isolated areas, because LANDSAT has a greater resolution than Skylab, it is more favorable for mapping the small vegetative categories.

The potable water system in Skylab

NASA Technical Reports Server (NTRS)

Sauer, R. L.; Westover, J. B.

1974-01-01

Description of the medical requirements, development, system operation, and in-flight performance of the Skylab potable water system. Emphasized is the description of the unique features involving new space-flight concepts, procedures, and design incorporated in Skylab. The water supplied to the three Skylab missions was preloaded in stainless-steel tanks. These tanks were fitted with positive expulsion stainless-steel bellows. In-flight iodination of the water, for bacterial control, was accomplished as required. An in-flight bactericide monitor was used periodically to determine the level of bactericide in the water. Prior to the delivery of the water to the crewmen for consumption, the water was passed through a cation exchange resin for metallic ion removal and then heated for food reconstitution or chilled for drinking.

Experiments with the Skylab fire detectors in zero gravity

NASA Technical Reports Server (NTRS)

Linford, R. M. F.

1972-01-01

The Skylab fire detector was evaluated in a zero gravity environment. To conduct the test, small samples of spacecraft materials were ignited in a 5 psi oxygen-rich atmosphere inside a combustion chamber. The chamber free-floated in the cabin of a C-135 aircraft, as the aircraft executed a Keplerian parabola. Up to 10 seconds of zero-gravity combustion were achieved. The Skylab fire-detector tubes viewed the flames from a simulated distance of 3m, and color movies were taken to record the nature of the fire. The experiments established the unique form of zero-gravity fires for a wide range of materials. From the tube-output data, the alarm threshold and detector time constant were verified for the Skylab Fire Detection System.

Internal Arrangement of Skylab Workshop Crew Quarters

NASA Technical Reports Server (NTRS)

1972-01-01

This image depicts a layout of the Skylab workshop 1-G trainer crew quarters. At left, in the sleep compartment, astronauts slept strapped to the walls of cubicles and showered at the center. Next right was the waste management area where wastes were processed and disposed. Upper right was the wardroom where astronauts prepared their meals and foods were stored. In the experiment operation area, upper left, against the far wall, was the lower-body negative-pressure device (Skylab Experiment M092) and the Ergometer for the vectorcardiogram experiment (Skylab Experiment M063). The trainers and mockups were useful in the developmental phase, while engineers and astronauts were still working out optimum designs. They provided much data applicable to the manufacture of the flight articles.

Some findings on the applications of ERTS and Skylab imagery for metropolitan land use analysis

NASA Technical Reports Server (NTRS)

Alexander, R. H. (Principal Investigator); Milazzo, V. A.

1974-01-01

The author has identified the following significant results. Work undertaken on a three-sensor land use data evaluation for a portion of the Phoenix area is reported. Analyses between land use data generated from 1970 high altitude photography and that detectable from ERTS and Skylab, especially in terms of changes in land use indicate that ERTS and Skylab imagery can be used effectively to detect and identify areas of post-1970 land use change, especially those documenting urban expansion at the rural-urban fringe. Significant preliminary findings on the utility of ERTS and Skylab data for metropolitan land use analysis, substantiated by evaluation with 1970 and 1972 ground control land use data are reported.

System safety checklist Skylab program report

NASA Technical Reports Server (NTRS)

Mcnail, E. M.

1974-01-01

Design criteria statement applicable to a wide variety of flight systems, experiments and other payloads, associated ground support equipment and facility support systems are presented. The document reflects a composite of experience gained throughout the aerospace industry prior to Skylab and additional experience gained during the Skylab Program. It has been prepared to provide current and future program organizations with a broad source of safety-related design criteria and to suggest methods for systematic and progressive application of the criteria beginning with preliminary development of design requirements and specifications. Recognizing the users obligation to shape the checklist to his particular needs, a summary of the historical background, rationale, objectives, development and implementation approach, and benefits based on Skylab experience has been included.

Solar sphere viewed through the Skylab solar physics experiment

NASA Technical Reports Server (NTRS)

1973-01-01

The solar sphere viewed through the Skylab solar physics experiment (S082) Extreme Ultraviolet Spectroheliographis seen in this photographic reproduction taken from a color television transmission made by a TV camera aboard the Skylab space station in Earth orbit. The solar chromosphere and lower corona are much hotter than the surface of the Sun characterized by the white light emissions. This image was recorded during the huge solar prominence which occurred on August 21, 1973.

Astronaut Paul Weitz works with UV Stellar Astronomy Experiment

NASA Image and Video Library

1973-03-01

S73-20716 (1 March 1973) --- Astronaut Paul J. Weitz, pilot of the first manned Skylab mission, works with the UV Stellar Astronomy Experiment S019 in the forward compartment of the Skylab Orbital Workshop (OWS) trainer during Skylab training at Johnson Space Center. The equipment consists of a reflecting telescope, a 35mm camera and an additional mirror. It is mounted in an anti-solar scientific airlock in the side of the OWS. Photo credit: NASA

Design criteria for payload workstation accommodations

NASA Technical Reports Server (NTRS)

Watters, H. H.; Stokes, J. W.

1975-01-01

Anticipated shuttle sortie payload man-system design criteria needs are investigated. Man-system interactions for the scientific disciplines are listed and the extent is assessed to which documented Skylab experience is expected to provide system design guidance for each of the identified interactions. Where the analysis revealed that the reduced Skylab data does not answer the anticipated needs candidate criteria, based on unreduced Skylab data, available prior research, original analysis, or related requirements derived from previous space programs, are provided.

Astronaut Alan Bean reads data from book while holding teleprinter tape

NASA Image and Video Library

1973-08-08

SL3-111-1514 (July-September 1973) --- Astronaut Alan L. Bean, Skylab 3 commander, reads data from book in his right hand while holding teleprinter tape in his left hand, in the ward room of the Skylab space station's Orbital Workshop (OWS) crew quarters. This photograph was taken with a 35mm Nikon camera held by one of Bean's fellow crewmen during the 56.5 day second manned Skylab mission in Earth orbit. Photo credit: NASA

Contamination from Skylab as determined from the solar coronagraph data

NASA Technical Reports Server (NTRS)

Mcguire, J. P.

1976-01-01

The white light solar coronagraph was one of the scientific telescopes flown on Skylab to study the sun. It studied the sun's atmosphere located from 0.5 to 5.0 solar radii above the sun's limb. Such a telescope is so sensitive to contamination around the spacecraft that it caused a major contamination abatement program to be initiated at the conception of Skylab. The coronagraph's data is analyzed showing the successfulness of that abatement program.

MSFC Skylab program engineering and integration

NASA Technical Reports Server (NTRS)

1974-01-01

A technical history and managerial critique of the MSFC role in the Skylab program is presented. The George C. Marshall Space Flight Center had primary hardware development responsibility for the Saturn Workshop Modules and many of the designated experiments in addition to the system integration responsibility for the entire Skylab Orbital Cluster. The report also includes recommendations and conclusions applicable to hardware design, test program philosophy and performance, and program management techniques with potential application to future programs.

Apollo Telescope Mount (ATM) gimballed star tracker. [developed for the Skylab program

NASA Technical Reports Server (NTRS)

Lana, J. D.

1974-01-01

Design and development of six gimballed star trackers for Skylab's Apollo Telescope Mount, which performed successfully on all three manned Skylab missions and accumulated a total usage time of approximately 3,500 hours, is described in terms of configurations, materials and construction, qualification testing, performance, and reliability characteristics. A brief program history and design changes incorporated during the life of the program are also discussed. Extensive drawings, block diagrams, and photographs are provided.

MSFC Skylab Apollo Telescope Mount experiment systems mission evaluation

NASA Technical Reports Server (NTRS)

White, A. F., Jr.

1974-01-01

A detailed evaluation is presented of the Skylab Apollo Telescope Mount experiments performance throughout the eight and one-half month Skylab Mission. Descriptions and the objectives of each instrument are included. The anomalies experienced, the causes, and corrective actions taken are discussed. Conclusions, based on evaluation of the performance of each instrument, are presented. Examples of the scientific data obtained, as well as a discussion of the quality and quantity of the data, are presented.

Astronaut Jack Lousma - Inflight Medical Support System (IMSS) - JSC

NASA Image and Video Library

1973-01-01

S73-28423 (16 June 1973) --- Astronaut Jack R. Lousma, Skylab 3 pilot, reaches into a medical kit, part of the Inflight Medical Support System (IMSS), during training for the second manned Skylab Earth-orbital mission. This activity took place in the OWS trainer in the Mission Simulation and Training Facility at the Johnson Space Center (JSC). Other Skylab 3 crewmen are astronaut Alan L. Bean, commander, and scientist-astronaut Owen K. Garriott, science pilot. Photo credit: NASA

Skylab 3 crew during press conference

NASA Image and Video Library

1973-06-30

S73-30110 (30 June 1973) --- The three members of the prime crew of the second manned Skylab mission (Skylab 3) discuss their scheduled 56-day flight before a gathering of news media representatives in the large auditorium of Building 1 at the Johnson Space Center (JSC), Houston, Texas, on June 30, 1973. They are, left to right, astronaut Alan L. Bean, commander; scientist-astronaut Owen K. Garriott, science pilot; and astronaut Jack R. Lousma, pilot. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-05-01

Sixty-three seconds after the launch of the modified Saturn V vehicle carrying the Skylab cluster, engineers in the operation support and control center saw an unexpected telemetry indication that signalled that damages occurred on one solar array and the micrometeoroid shield during the launch. Still unoccupied, the Skylab was stricken with the loss of the heat shield and sunlight beat mercilessly on the lab's sensitive skin. Internal temperatures soared, rendering the the station uninhabitable, threatening foods, medicines, films, and experiments. The launch of the first marned Skylab (Skylab-2) mission was delayed until methods were devised to repair and salvage the workshop. Personnel from other NASA Centers and industries quickly joined the Marshall Space Flight Center (MSFC) in efforts to save the damaged Skylab. They worked day and night for the next several days. Eventually the MSFC developed, tested, rehearsed, and approved three repair options. These options included a parasol sunshade and a twin-pole sunshade to restore the temperature inside the workshop, and a set of metal cutting tools to free the jammed solar panel. This photograph was taken during a discussion of the methods of the twin-pole Sun shield by (left to right) Astronaut Alan Bean, MSFC Director Dr. Rocco Petrone, Astronaut Edward Gibson, and MSFC engineer Richard Heckman. Dr. William Lucas, who became MSFC Director after Dr. Petrone left MSFC in March of 1974, is standing.

MSFC integrated experiments preliminary report. [for the Skylab program

NASA Technical Reports Server (NTRS)

1974-01-01

Skylab experiments are described and their preliminary results are reported. The types of experiments described include medical, earth resources, space physics, space manufacturing, and spacecraft design.

Skylab

NASA Image and Video Library

1972-08-21

Youngstown, Ohio high school student, W. Brian Dunlap (center), discusses with Dr. Robert Head (right), and Henry Floyd, both of the Marshall Space Flight Center (MSFC), his experiment to be performed aboard the Skylab the following year. His experiment, “Wave Motion Trough A Liquid in Zero Gravity” used a container attached to the end of a leaf spring which was oscillated at specific rates using two thickness differentiated types of liquids. Dunlap was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

Wreath for Bill Pogue Memorial

NASA Image and Video Library

2014-03-14

CAPE CANAVERAL, Fla. – Former NASA astronauts Gerald P. Carr, left, and Edward G. Gibson place a wreath on an easel during a ceremony to honor former NASA astronaut William R. Pogue at the United States Astronaut Hall of Fame at the Kennedy Space Center Visitor Complex. In the background is a painting by former NASA astronaut Alan Bean. Col. Pogue, pilot on NASA's Skylab 4 mission in 1973-74, died March 3. He was 84 years old. Skylab 4 was the third and final manned visit to the Skylab orbital workshop, launched Nov. 16, 1973, and concluded Feb. 8, 1974. At 84 days, 1 hour and 15 minutes, Skylab 4 was the longest manned space flight to that date. Pogue was accompanied on the record-setting 34.5-million-mile flight by Commander Carr and science-pilot Gibson. They conducted dozens of experiments and science demonstrations during their 1,214 orbits of Earth. Pogue logged 13 hours and 31 minutes in two spacewalks outside the orbital workshop. For more information, visit http://www.nasa.gov/content/skylab-4-pilot-william-pogue-dies. Photo credit: NASA/Kim Shiflett

Skylab

NASA Image and Video Library

1972-08-21

Rockford, Illinois high school student, Vincent Converse (left), and Robert Head of the Marshall Space Flight Center (MSFC), check out the equipment to be used in conducting the student’s experiment aboard the Skylab the following year. His experiment, “Zero Gravity Mass Measurement” used a simple leaf spring with the mass to be weighed attached to the end. An electronic package oscillated the spring at a specific rate and the results were recorded electronically. Converse was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC two months earlier where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

View of Island of Kyushu, Japan from Skylab

NASA Image and Video Library

1974-01-07

SL4-139-3942 (7 Jan. 1974) --- This oblique view of the Island of Kyushu, Japan, was taken from the Earth-orbiting Skylab space station on Jan. 8, 1974 during its third manning. A plume from the volcano Sakurajima (bottom center) is clearly seen as it extends about 80 kilometers (50 miles) east from the volcano. (EDITOR'S NOTE: On Jan. 10, 2013, a little over 39 years after this 1974 photo was made from the Skylab space station, Expedition 34 crew members aboard the International Space Station took a similar picture (frame no. ISS034-E-027139) featuring smoke rising from the same volcano, with much of the island of Kyushu visible. Interesting comparisons can be made between the two photos, at least as far as the devices used to record them. The Skylab image was made by one of the three Skylab 4 crew members with a hand-held camera using a 100-mm lens and 70-mm color film, whereas the station photo was taken with 180-mm lens on a digital still camera, hand-held by one of the six crew members). Photo credit: NASA

Skylab

NASA Image and Video Library

1970-01-01

This photograph shows technicians installing the meteoroid shield on the Thruster Attitude Control Subsystem (TACS). At one end of the Orbital Workshop (OWS), the TACS provided short-term control of the attitude of the Skylab.

SKYLAB (SL)-3 - TELEVISION

NASA Image and Video Library

1973-09-29

S73-34619 (28 July 1973) --- A composite of four frames taken from 16mm movie camera footage showing an overhead view of the Skylab space station cluster in Earth orbit. The Maurer motion picture camera scenes were being filmed during the Skylab 3 Command/Service Module's (CSM) first "fly around" inspection of the space station. Close comparison of the four frames reveals movement of the improvised parasol solar shield over the Orbital Workshop (OWS). The "flapping" of the sun shade was caused from the exhaust of the reaction control subsystem (RCS) thrusters of the Skylab 3 CSM. The one remaining solar array system wing on the OWS is in the lower left background. The solar panel in the lower left foreground is on the Apollo Telescope Mount (ATM). Photo credit: NASA

Skylab food system

NASA Technical Reports Server (NTRS)

Bush, W. H.

1974-01-01

The Skylab food program was a major effort involving a complex spectrum of activities necessary for the preparation of a crew feeding system. Approximately 17,000 individual food packages and support items, weighing more than 1225 kg, were launched into space as a single unit on board the orbital workshop. This unit provided the three (three-man) Skylab crews with nourishing foods and beverages for a total of 156 days, as well as with eating utensils and accessory items. Additionally, provisions for 5 days (15 man-days) were provided in each of the three command and service modules in a manner similar to that of the Apollo flights. The Skylab food system not only provided the crew with a palatable balanced diet in a familiar and acceptable manner but also supported the formidable mineral balance medical experiment series (M070).

Skylab

NASA Image and Video Library

1973-05-01

Engineers from the Marshall Space Flight Center (MSFC) and its contractors were testing the twin-pole sunshade at the Skylab mockup in the MSFC Building 4619. The Skylab Orbital Workshop (OWS) lost its thermal protection shield during launch on May 14, 1963. Without the heat shield, the temperature inside the OWS became dangerously high, rendering the workshop uninhabitable and threatened deterioration of the interior insulation and adhesive. Engineers from the MSFC, its contractors, and NASA persornel at other centers worked day and night for several days to develop the way to save the Skylab OWS. Eventually, they developed, tested, rehearsed, and approved three repair options. These options included a parasol sunshade and a twin-pole sunshade to restore the temperature inside the workshop, and a set of metal cutting tools to free the jammed solar panel.

Skylab

NASA Image and Video Library

1972-06-02

W. Brain Dunlap (left), high school student from Youngstown, Ohio, is pictured here with Harry Coons of the Marshall Space Flight Center (MSFC) during a visit to the center. Dunlap was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Princeton, New Jersey high school student, Alison Hopfield, is greeted by astronauts Russell L. Schweickart (left) and Owen K. Garriott (center) during a tour of the Marshall Space Flight Center (MSFC). Hopfield was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Skylab

NASA Image and Video Library

1972-06-02

Gregory A. Merkel (left), high school student from Springfield, Massachusetts, is pictured here with Harry Coons of the Marshall Space Flight Center (MSFC) during a visit to the center. Merkel was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

SL3-111-01519

NASA Image and Video Library

1973-08-06

SL3-111-1519 (6 Aug. 1973) --- Scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, reconstitutes a pre-packaged container of food at the crew quarters ward room table of the Orbital Workshop (OWS) of the Skylab Space Station cluster. This picture was taken with a hand-held 35mm Nikon camera. Astronauts Garriott, Alan L. Bean and Jack R. Lousma remained with the Skylab Space Station in Earth orbit for a total of 59 days conducting numerous medical, scientific and technological experiments. Note the knife and fork on the food tray and the utensil with which Garriott stirs the food mixed with water. Skylab is the first manned space program by NASA which affords the crew men an opportunity to eat with the same type utensils used on Earth. Photo credit: NASA

Skylab food system laboratory support

NASA Technical Reports Server (NTRS)

Sanford, D.

1974-01-01

A summary of support activities performed to ensure the quality and reliability of the Skylab food system design is reported. The qualification test program was conducted to verify crew compartment compatibility, and to certify compliance of the food system with nutrition, preparation, and container requirements. Preflight storage requirements and handling procedures were also determined. Information on Skylab food items was compiled including matters pertaining to serving size, preparation information, and mineral, calorie, and protein content. Accessory hardware and the engraving of food utensils were also considered, and a stowage and orientation list was constructed which takes into account menu use sequences, menu items, and hardware stowage restrictions. A food inventory system was established and food thermal storage tests were conducted. Problems and comments pertaining to specific food items carried onboard the Skylab Workshop were compiled.

Task-parallel message passing interface implementation of Autodock4 for docking of very large databases of compounds using high-performance super-computers.

PubMed

Collignon, Barbara; Schulz, Roland; Smith, Jeremy C; Baudry, Jerome

2011-04-30

A message passing interface (MPI)-based implementation (Autodock4.lga.MPI) of the grid-based docking program Autodock4 has been developed to allow simultaneous and independent docking of multiple compounds on up to thousands of central processing units (CPUs) using the Lamarkian genetic algorithm. The MPI version reads a single binary file containing precalculated grids that represent the protein-ligand interactions, i.e., van der Waals, electrostatic, and desolvation potentials, and needs only two input parameter files for the entire docking run. In comparison, the serial version of Autodock4 reads ASCII grid files and requires one parameter file per compound. The modifications performed result in significantly reduced input/output activity compared with the serial version. Autodock4.lga.MPI scales up to 8192 CPUs with a maximal overhead of 16.3%, of which two thirds is due to input/output operations and one third originates from MPI operations. The optimal docking strategy, which minimizes docking CPU time without lowering the quality of the database enrichments, comprises the docking of ligands preordered from the most to the least flexible and the assignment of the number of energy evaluations as a function of the number of rotatable bounds. In 24 h, on 8192 high-performance computing CPUs, the present MPI version would allow docking to a rigid protein of about 300K small flexible compounds or 11 million rigid compounds.

Skylab 3,Astronaut Jack R. Lousma on EVA

NASA Image and Video Library

1973-08-06

SL3-122-2612 (6 Aug. 1973) --- Astronaut Alan L. Bean, Skylab 3 commander, participates in the final Skylab 3 extravehicular activity (EVA), during which a variety of tasks were performed. Here, Bean is near the Apollo Telescope Mount (ATM) during final film change out for the giant telescope facility. Astronaut Owen K. Garriott, who took the picture, is reflected in Bean's helmet visor. The reflected Earth disk in Bean's visor is so clear that the Red Sea and Nile River area can delineated. Photo credit: NASA

Cost analysis of carbon dioxide concentrators

NASA Technical Reports Server (NTRS)

Yakut, M. M.

1973-01-01

Methodology and cost estimating relationships, for flight-type and prototype CO2 concentrators, have been developed and presented. A validity check was made by comparing the molecular sieves system considered here and that developed for Skylab. The system evaluated here is twice the size of the Skylab system and is also more complex as it desorbs CO2 thermally and stores it in an accumulator. The cost estimates developed were found to be approximately 50 to 70% higher than the actual cost of the Skylab unit.

Skylab

NASA Image and Video Library

1973-01-01

This chart details Skylab's In-Flight Lower Body Negative Pressure experiment facility, a medical evaluation designed to monitor changes in astronauts' cardiovascular systems during long-duration space missions. This experiment collected in-flight data for predicting the impairment of physical capacity and the degree of orthostatic intolerance to be expected upon return to Earth. Data to be collected were blood pressure, heart rate, body temperature, vectorcardiogram, lower body negative pressure, leg volume changes, and body mass. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows Skylab's In-Flight Lower Body Negative Pressure experiment facility, a medical evaluation designed to monitor changes in astronauts' cardiovascular systems during long-duration space missions. This experiment collected in-flight data for predicting the impairment of physical capacity and the degree of orthostatic intolerance to be expected upon return to Earth. Data to be collected were blood pressure, heart rate, body temperature, vectorcardiogram, lower body negative pressure, leg volume changes, and body mass. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Solar sphere viewed through the Skylab solar physics experiment

NASA Image and Video Library

1973-08-21

S73-32867 (21 Aug. 1973) --- The solar sphere viewed through the Skylab solar physics experiment (S082) Extreme Ultraviolet Spectroheliographis seen in this photographic reproduction taken from a color television transmission made by a TV camera aboard the Skylab space station in Earth orbit. The solar chromosphere and lower corona are much hotter than the surface of the sun characterized by the white light emissions. This image was recorded during the huge solar prominence which occurred on Aug. 21, 1973. Photo credit: NASA

Skylab 3 crewmen shown eating in Orbital Workshop wardroom

NASA Image and Video Library

1973-08-01

S73-31705 (1 Aug. 1973) --- The three Skylab 3 crewmen are shown eating in the Orbital Workshop (OWS) wardroom of the Skylab space station in Earth orbit, in this photographic reproduction taken from a television transmission made by a color TV camera aboard the OWS. Astronaut Alan L. Bean (right), commander, illustrates eating under zero-gravity conditions upsidedown. The two other crewmen are scientist-astronaut Owen K. Garriott (left), science pilot; and astronaut Jack R. Lousma, pilot. Photo credit: NASA

Skylab experiments. Volume 3: Materials science. [Skylab experiments on metallurgy, crystal growth, semiconductors, and combustion physics in weightless environment for high school level education

NASA Technical Reports Server (NTRS)

1973-01-01

The materials science and technology investigation conducted on the Skylab vehicle are discussed. The thirteen experiments that support these investigations have been planned to evaluate the effect of a weightless environment on melting and resolidification of a variety of metals and semiconductor crystals, and on combustion of solid flammable materials. A glossary of terms which define the space activities and a bibliography of related data are presented.

The Skylab Student Project. [high school winners selection and experiments description

NASA Technical Reports Server (NTRS)

Floyd, H. B.

1973-01-01

The National Aeronautics and Space Administration (NASA) and the National Science Teachers' Association (NSTA) undertook in 1971 a cooperative effort which brought high school students of the Nation into the mainstream of Skylab research through the Skylab Student Project. This paper presents the background, objectives and scope of the project, experiment selection procedures, as well as experiment descriptions and status. The paper includes observations on student caliber and inclinations and implications of some developments for the benefit of future researchers.

SKYLAB (SL)-2 - LAUNCH - KSC

NASA Image and Video Library

1973-05-31

S73-27095 (25 May 1973) --- The Skylab 2 crew, consisting of astronauts Charles Conrad Jr., Joseph P. Kerwin and Paul J. Weitz, inside the command module atop a Saturn IB launch vehicle, heads toward the Skylab space station in Earth orbit. The command module was inserted into Earth orbit approximately 10 minutes after liftoff. The three represent the first of three crews who will spend record-setting durations for human beings in space, while performing a variety of experiments. Photo credit: NASA

SKYLAB (SL)-2 - LAUNCH - KSC

NASA Image and Video Library

1973-05-31

S73-27096 (25 May 1973) --- The Skylab 2 crew, consisting of astronauts Charles Conrad Jr., Joseph P. Kerwin and Paul J. Weitz, inside the command module atop a Saturn IB launch vehicle, heads toward the Skylab space station in Earth orbit. The command module was inserted into Earth orbit approximately 10 minutes after liftoff. The three represent the first of three crews who will spend record-setting durations for human beings in space, while performing a variety of experiments. Photo credit: NASA

Facilities. [for Skylab environment simulation

NASA Technical Reports Server (NTRS)

Battaglia, H. F.; Burgett, F. A.; Casey, L. O.; Correale, J. V.; Dunaway, J. Q.; Glover, W. G.; Hinners, A. H., Jr.; Leblanc, J. C.; Leech, T. B.; Mays, J. D.

1973-01-01

Detailed descriptions are provided for mechanical devices, life support systems, and data handling and communications instrumentation that are connected with the altitude chamber in which the Skylab medical experiments altitude tests were performed.

Multi-Axis Independent Electromechanical Load Control for Docking System Actuation Development and Verification Using dSPACE

NASA Technical Reports Server (NTRS)

Oesch, Christopher; Dick, Brandon; Rupp, Timothy

2015-01-01

The development of highly complex and advanced actuation systems to meet customer demands has accelerated as the use of real-time testing technology expands into multiple markets at Moog. Systems developed for the autonomous docking of human rated spacecraft to the International Space Station (ISS), envelope multi-operational characteristics which place unique constraints on an actuation system. Real-time testing hardware has been used as a platform for incremental testing and development for the linear actuation system which controls initial capture and docking for vehicles visiting the ISS. This presentation will outline the role of dSPACE hardware as a platform for rapid control-algorithm prototyping as well as an Electromechanical Actuator (EMA) system dynamic loading simulator, both conducted at Moog to develop the safety critical Linear Actuator System (LAS) of the NASA Docking System (NDS).

Skylab

NASA Image and Video Library

1971-06-01

The Apollo Telescope Mount (ATM), one of four major components comprising the Skylab, was designed and developed by the Marshall Space Flight Center. In this image, the ATM is shown undergoing horizontal vibration testing in a vibration test unit.

SKYLAB II - EARTH VIEW (EREP)

NASA Image and Video Library

1973-09-20

S73-34295 (June 1973) --- A vertical view of a portion of northern California reproduced from data taken from the Skylab Multispectral Scanner, experiment S192, in the Skylab space station in Earth orbit. This view is the most westerly one-third of Frame No. 001, Roll No. 518, S192, Skylab 2. Frame No. 001 extends from the Pacific coast at the Eureka area southeasterly 175 nautical miles to the Feather River drainage basin. Included in this view are Eureka, Trinidad, Klamath & Trinity Rivers and the Coastal Range mountains. This non-photographic image is a color composite of channels 2 (visible), 7, and 12 (infrared) from the Earth Resources Experiments Package (EREP) S192 scanner. The scanner techniques assist with spectral signature identification and mapping of ground truth targets in agriculture, forestry, geology, hydrology and oceanography. Photo credit: NASA

Skylab

NASA Image and Video Library

1973-01-01

This chart describes the Skylab student experiment ED-61, Plant Growth, and experiment ED-62, Plant Phototropism. Two similar proposals were submitted by Joel G. Wordekemper of West Point, Nebraska, and Donald W. Schlack of Downey, California. Wordekemper's experiment (ED-61) was to see how the lack of gravity would affect the growth of roots and stems of plants. Schlack's experiment (ED-62) was to study the effect of light on a seed developing in zero gravity. The growth container of the rice seeds for their experiment consisted of eight compartments arranged in two parallel rows of four. Each had two windowed surfaces to allow periodic photography of the developing seedlings. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

The Skylab barium plasma injection experiments. I - Convection observations

NASA Technical Reports Server (NTRS)

Wescott, E. M.; Stenbaek-Nielsen, H. C.; Davis, T. N.; Peek, H. M.

1976-01-01

Two barium-plasma injection experiments were carried out during magnetically active periods in conjunction with the Skylab 3 mission. The high-explosive shaped charges were launched near dawn on November 27 and December 4, 1973, UT. In both cases, the AE index was near 400 gammas, and extensive pulsating auroras covered the sky. The first experiment, Skylab Alpha, occurred in the waning phase of a 1000-gamma substorm, and the second, Skylab Beta, occurred in the expansive phase of an 800-gamma substorm. In both, the convection was generally magnetically eastward, with 100-km-level electric fields near 40 mV/m. However, in the Alpha experiment the observed orientation of the barium flux tube fit theoretical field lines having no parallel current, but the Beta flux-tube orientation indicated a substantial upward parallel sheet current.

KSC-2013-3125

NASA Image and Video Library

2013-07-27

CAPE CANAVERAL, Fla. – At the Kennedy Space Center's Apollo/Saturn V Center, former NASA astronaut Alan Bean speaks to guests at the Astronaut Scholarship Foundation's event celebrating the 40th anniversary of Skylab. Bean served as commander of Skylab 3, the second piloted mission to the space station. In 1969, Bean was lunar module pilot on Apollo 12, the second mission to land on the moon. The gala commemorating the 40th anniversary of Skylab included six of the nine astronauts who flew missions to America's first space station. The orbiting laboratory was launched unpiloted from Kennedy on May 14, 1973. Between May 25, 1973 and Feb. 8, 1974, crews of three spent 28, 59 and 84 days living and working in low-Earth orbit aboard the station. For more information, visit http://www.nasa.gov/mission_pages/skylab/ Photo credit: NASA/Kim Shiflett

Cytoplasmic Streaming - Skylab Student Experiment ED-63

NASA Technical Reports Server (NTRS)

1973-01-01

This chart describes the Skylab student experiment (ED-63), Cytoplasmic Streaming, proposed by Cheryl A. Peitz of Arapahoe High School, Littleton, Colorado. Experiment ED-63 was to observe the effect of zero-gravity on cytoplasmic streaming in the aquatic plant named Elodea, commonly called water weed or water thyme. The phenomenon of cytoplasmic streaming is not well understood, but it is recognized as the circulation mechanism of the internal materials or cytoplasm of a cell. Cytoplasm is a gelatinous substance that has the ability to change its viscosity and flow, carrying various cell materials with it. The activity can be stimulated by sunlight or heat. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Manned space stations - A perspective

NASA Astrophysics Data System (ADS)

Disher, J. H.

1981-09-01

The findings from the Skylab missions are discussed as they relate to the operations planning of future space stations such as Spacelab and the proposed Space Operations Center. Following a brief description of the Skylab spacecraft, the significance of the mission as a demonstration of the possibility of effecting emergency repairs in space is pointed out. Specific recommendations made by Skylab personnel concerning capabilities for future in-flight maintenance are presented relating to the areas of spacecraft design criteria, tool selection and spares carried. Attention is then given to relevant physiological findings, and to habitability considerations in the areas of sleep arrangements, hygiene, waste management, clothing, and food. The issue of contamination control is examined in detail as a potential major system to be integrated into future design criteria. The importance of the Skylab results to the designers of future space stations is emphasized.

Engineer's drawing of Skylab 4 Far Ultraviolet Electronographic camera

NASA Image and Video Library

1973-11-19

S73-36910 (November 1973) --- An engineer's drawing of the Skylab 4 Far Ultraviolet Electronographic camera (Experiment S201). Arrows point to various features and components of the camera. As the Comet Kohoutek streams through space at speeds of 100,000 miles per hour, the Skylab 4 crewmen will use the S201 UV camera to photograph features of the comet not visible from the Earth's surface. While the comet is some distance from the sun, the camera will be pointed through the scientific airlock in the wall of the Skylab space station Orbital Workshop (OWS). By using a movable mirror system built for the Ultraviolet Stellar Astronomy (S019) Experiment and rotating the space station, the S201 camera will be able to photograph the comet around the side of the space station. Photo credit: NASA

Message passing interface and multithreading hybrid for parallel molecular docking of large databases on petascale high performance computing machines.

PubMed

Zhang, Xiaohua; Wong, Sergio E; Lightstone, Felice C

2013-04-30

A mixed parallel scheme that combines message passing interface (MPI) and multithreading was implemented in the AutoDock Vina molecular docking program. The resulting program, named VinaLC, was tested on the petascale high performance computing (HPC) machines at Lawrence Livermore National Laboratory. To exploit the typical cluster-type supercomputers, thousands of docking calculations were dispatched by the master process to run simultaneously on thousands of slave processes, where each docking calculation takes one slave process on one node, and within the node each docking calculation runs via multithreading on multiple CPU cores and shared memory. Input and output of the program and the data handling within the program were carefully designed to deal with large databases and ultimately achieve HPC on a large number of CPU cores. Parallel performance analysis of the VinaLC program shows that the code scales up to more than 15K CPUs with a very low overhead cost of 3.94%. One million flexible compound docking calculations took only 1.4 h to finish on about 15K CPUs. The docking accuracy of VinaLC has been validated against the DUD data set by the re-docking of X-ray ligands and an enrichment study, 64.4% of the top scoring poses have RMSD values under 2.0 Å. The program has been demonstrated to have good enrichment performance on 70% of the targets in the DUD data set. An analysis of the enrichment factors calculated at various percentages of the screening database indicates VinaLC has very good early recovery of actives. Copyright © 2013 Wiley Periodicals, Inc.

ProSelection: A Novel Algorithm to Select Proper Protein Structure Subsets for in Silico Target Identification and Drug Discovery Research.

PubMed

Wang, Nanyi; Wang, Lirong; Xie, Xiang-Qun

2017-11-27

Molecular docking is widely applied to computer-aided drug design and has become relatively mature in the recent decades. Application of docking in modeling varies from single lead compound optimization to large-scale virtual screening. The performance of molecular docking is highly dependent on the protein structures selected. It is especially challenging for large-scale target prediction research when multiple structures are available for a single target. Therefore, we have established ProSelection, a docking preferred-protein selection algorithm, in order to generate the proper structure subset(s). By the ProSelection algorithm, protein structures of "weak selectors" are filtered out whereas structures of "strong selectors" are kept. Specifically, the structure which has a good statistical performance of distinguishing active ligands from inactive ligands is defined as a strong selector. In this study, 249 protein structures of 14 autophagy-related targets are investigated. Surflex-dock was used as the docking engine to distinguish active and inactive compounds against these protein structures. Both t test and Mann-Whitney U test were used to distinguish the strong from the weak selectors based on the normality of the docking score distribution. The suggested docking score threshold for active ligands (SDA) was generated for each strong selector structure according to the receiver operating characteristic (ROC) curve. The performance of ProSelection was further validated by predicting the potential off-targets of 43 U.S. Federal Drug Administration approved small molecule antineoplastic drugs. Overall, ProSelection will accelerate the computational work in protein structure selection and could be a useful tool for molecular docking, target prediction, and protein-chemical database establishment research.

Miles Discusses Skylab Experiment With NASA Personnel

NASA Technical Reports Server (NTRS)

1972-01-01

Lexington, Massachusetts high school student, Judith Miles, discusses her proposed Skylab experiment with engineers and scientists during a design review of the experiment equipment. At left is Ron Pavlue of Kennedy Space Flight Center (KSC), holding a box is Keith Demorest of Marshall Space Flight Center (MSFC). Right of Miles is Dr. Raymond Gause, also of MSFC, who is Miles' scientific advisor. In her experiment, called the 'Web Formation in Zero Gravity', spiders were released into a box and their actions recorded to determine how well they adapt to the absence of gravity. Spiders are known to adapt quickly to other changes in the environment but nothing was known of their ability to adapt to weightlessness. At the same time spiders were weaving webs in Earth orbit, similar spiders were spinning webs in identical boxes on Earth under full gravity conditions. Miles was among the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment.

Skylab

NASA Image and Video Library

1972-08-21

Lexington, Massachusetts high school student, Judith Miles, discusses her proposed Skylab experiment with engineers and scientists during a design review of the experiment equipment. At left is Ron Pavlue of Kennedy Space Flight Center (KSC), holding a box is Keith Demorest of Marshall Space Flight Center (MSFC). Right of Miles is Dr. Raymond Gause, also of MSFC, who is Miles’ scientific advisor. In her experiment, called the “Web Formation in Zero Gravity”, spiders were released into a box and their actions recorded to determine how well they adapt to the absence of gravity. Spiders are known to adapt quickly to other changes in the environment but nothing was known of their ability to adapt to weightlessness. At the same time spiders were weaving webs in Earth orbit, similar spiders were spinning webs in identical boxes on Earth under full gravity conditions. Miles was among the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment.

Wreath for Bill Pogue Memorial

NASA Image and Video Library

2014-03-14

CAPE CANAVERAL, Fla. – From left, former NASA astronauts Robert Cabana, Gerald P. Carr and Edward G. Gibson pay their respects to former NASA astronaut William R. Pogue during a wreath laying ceremony at the United States Astronaut Hall of Fame at the Kennedy Space Center Visitor Complex. Cabana now is the director of Kennedy Space Center. In the background is a painting by former NASA astronaut Alan Bean. Col. Pogue, pilot on NASA's Skylab 4 mission in 1973-74, died March 3. He was 84 years old. Skylab 4 was the third and final manned visit to the Skylab orbital workshop, launched Nov. 16, 1973, and concluded Feb. 8, 1974. At 84 days, 1 hour and 15 minutes, Skylab 4 was the longest manned space flight to that date. Pogue was accompanied on the record-setting 34.5-million-mile flight by Commander Carr and science-pilot Gibson. They conducted dozens of experiments and science demonstrations during their 1,214 orbits of Earth. Pogue logged 13 hours and 31 minutes in two spacewalks outside the orbital workshop. For more information, visit http://www.nasa.gov/content/skylab-4-pilot-william-pogue-dies. Photo credit: NASA/Kim Shiflett

Skylab study of water quality. [Kansas reservoirs

NASA Technical Reports Server (NTRS)

Yarger, H. L. (Principal Investigator); Mccauley, J. R.

1974-01-01

The author has identified the following significant results. Analysis of S-190A imagery from 1 EREP pass over 3 reservoirs in Kansas establishes a strong linear correlation between the red/green radiance ratio and suspended solids. This result compares quite favorably to ERTS MSS CCT results. The linear fits RMS for Skylab is 6 ppm as compared to 12 ppm for ERTS. All of the ERTS satellite passes yielded fairly linear results with typical RMS values of 12 ppm. However, a few of the individual passes did yield RMS values of 5 or 6 ppm which is comparable to the one Skylab pass analyzed. In view of the cloudy conditions in the Skylab photos, yet good results, the indications are that S-190A may do somewhat better than the ERTS MSS in determining suspended load. More S-190A data is needed to confirm this. As was the case with the ERTS MSS, the Skylab S-190A showed no strong correlation with other water quality parameters. S-190B photos because of their high resolution can provide much first look information regarding relative degrees of turbidity within various parts of large lakes and among smaller bodies of water.

Assessment of Spatial Navigation and Docking Performance During Simulated Rover Tasks

NASA Technical Reports Server (NTRS)

Wood, S. J.; Dean, S. L.; De Dios, Y. E.; Moore, S. T.

2010-01-01

INTRODUCTION: Following long-duration exploration transits, pressurized rovers will enhance surface mobility to explore multiple sites across Mars and other planetary bodies. Multiple rovers with docking capabilities are envisioned to expand the range of exploration. However, adaptive changes in sensorimotor and cognitive function may impair the crew s ability to safely navigate and perform docking tasks shortly after transition to the new gravitoinertial environment. The primary goal of this investigation is to quantify post-flight decrements in spatial navigation and docking performance during a rover simulation. METHODS: Eight crewmembers returning from the International Space Station will be tested on a motion simulator during four pre-flight and three post-flight sessions over the first 8 days following landing. The rover simulation consists of a serial presentation of discrete tasks to be completed within a scheduled 10 min block. The tasks are based on navigating around a Martian outpost spread over a 970 sq m terrain. Each task is subdivided into three components to be performed as quickly and accurately as possible: (1) Perspective taking: Subjects use a joystick to indicate direction of target after presentation of a map detailing current orientation and location of the rover with the task to be performed. (2) Navigation: Subjects drive the rover to the desired location while avoiding obstacles. (3) Docking: Fine positioning of the rover is required to dock with another object or align a camera view. Overall operator proficiency will be based on how many tasks the crewmember can complete during the 10 min time block. EXPECTED RESULTS: Functionally relevant testing early post-flight will develop evidence regarding the limitations to early surface operations and what countermeasures are needed. This approach can be easily adapted to a wide variety of simulated vehicle designs to provide sensorimotor assessments for other operational and civilian populations.

Spaceflight tracking and data network operational reliability assessment for Skylab

NASA Technical Reports Server (NTRS)

Seneca, V. I.; Mlynarczyk, R. H.

1974-01-01

Data on the spaceflight communications equipment status during the Skylab mission were subjected to an operational reliability assessment. Reliability models were revised to reflect pertinent equipment changes accomplished prior to the beginning of the Skylab missions. Appropriate adjustments were made to fit the data to the models. The availabilities are based on the failure events resulting in the stations inability to support a function of functions and the MTBF's are based on all events including 'can support' and 'cannot support'. Data were received from eleven land-based stations and one ship.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows the Skylab's Ultraviolet (UV) Spectrograph, an Apollo Telescope Mount instrument. Its telescope, with camera and TV capability, photographed the Sun in selected ultraviolet wavelengths. The spectrograph was used to record the spectrum of UV emissions, such as flares or filaments, from a small individual feature on the solar disc. Real-time TV was used by the crew to monitor the performance of the telescope, transmit to the ground, and record. The exposed films were retrieved by astronaut extravehicular activities. The Marshall Space Flight Center had program management responsibility for the development of the Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1973-01-01

This 1973 chart details Skylab's Ultraviolet (UV) Spectrograph, an Apollo Telescope Mount instrument. Its telescope, with camera and TV capability, photographed the Sun in selected ultraviolet wavelengths. The spectrograph was used to record the spectrum of UV emissions, such as flares or filaments, from a small individual feature on the solar disc. Real-time TV was used by the crew to monitor performance of the telescope, transmit to the ground and record. The exposed films were retrieved by astronaut extravehicular activities. The Marshall Space Flight Center had program management responsibility for the development of the Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1972-01-01

This chart details Skylab's Metabolic Activity experiment (M171), a medical evaluation facility designed to measure astronauts' metabolic changes while on long-term space missions. The experiment obtained information on astronauts' physiological capabilities and limitations and provided data useful in the design of future spacecraft and work programs. Physiological responses to physical activity was deduced by analyzing inhaled and exhaled air, pulse rate, blood pressure, and other selected variables of the crew while they performed controlled amounts of physical work with a bicycle ergometer. The Marshall Space Flight Center had program responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1973-01-01

This Skylab-3 onboard photograph shows Astronaut Allen Bean on the ergometer, breathing into the metabolic analyzer. Skylab's Metabolic Activity experiment (M171), a medical evaluation facility, was designed to measure astronauts' metabolic changes while on long-term space missions. The experiment obtained information on astronauts' physiological capabilities and limitations and provided data useful in the design of future spacecraft and work programs. Physiological responses to physical activity was deduced by analyzing inhaled and exhaled air, pulse rate, blood pressure, and other selected variables of the crew while they performed controlled amounts of physical work with a bicycle ergometer.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows Skylab's Infrared Spectrometer Viewfinder Tracking System, a major component of an Earth Resources Experiment Package (EREP). It was designed to evaluate Earth resources sensors for specific regions of the the visible and infrared spectra and assess the value of real time identification of ground sites. The overall purpose of the EREP was to test the use of sensors that operated in the visible, infrared, and microwave portions of the electromagnetic spectrum to monitor and study Earth resources. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1970-01-01

Skylab's Body Mass Measurement chair, the facility of the Body Mass Measurement experiment (M172), is shown here in this 1970 photograph. The M172 experiment determined the body mass of each crew member and observed changes in body masses during flight. Knowledge of exact body mass variations throughout the flight in significantly aided in the correlation of other medical data obtained during the flight. Mass measurements under zero-gravity conditions were achieved by the application of Newton's second law (force equals mass times acceleration). The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Analysis of Skylab fluid mechanics science demonstrations

NASA Technical Reports Server (NTRS)

Tegart, J. R.; Butz, J. R.

1975-01-01

The results of the data reduction and analysis of the Skylab fluid mechanics demonstrations are presented. All the fluid mechanics data available from the Skylab missions were identified and surveyed. The significant fluid mechanics phenomena were identified and reduced to measurable quantities wherever possible. Data correlations were performed using existing theories. Among the phenomena analyzed were: static low-g interface shapes, oscillation frequency and damping of a liquid drop, coalescence, rotating drop, liquid films and low-g ice melting. A survey of the possible applications of the results was made and future experiments are recommended.

Mercury, Skylab, Spacehab, International Space Station: A Continuum

NASA Technical Reports Server (NTRS)

Walker, Charles; Crouch, Roger K.; Binnenbruck, Horsta; Nagaoka, Shunji; Riesselmann, Werner

2000-01-01

We have conducted real research in space. Virtually all that we conducted in the first decade and a half of the space age was government funded and basic research like the carrier vehicles we call satellites and Sputniki, but direction human interaction began with Project Mercury. When the Apollo program ended with success, we got back to research again. Skylab was using Apollo hardware, using Apollo systems in a manner that offered spacious accomodations for researchers. Education began to move into space. This document describes Skylab's role in spaceborne experiments.

Skylab (SL)-3 - Astronaut Jack R. Lousma - Utensils

NASA Image and Video Library

1973-09-19

S73-34198 (1 Aug. 1973) --- A close-up view of the hands of astronaut Jack R. Lousma, Skylab 3 pilot, using a silverware utensil to gather food at the food station, in this photographic reproduction taken from a television transmission made by a color TV camera aboard the Skylab space station in Earth orbit. Astronaut Alan L. Bean, commander, had just zoomed the TV camera in for this close-up of the food tray following a series of wide shots of Lousma at the food station. Photo credit: NASA

Comparative utility of LANDSAT-1 and Skylab data for coastal wetland mapping and ecological studies

NASA Technical Reports Server (NTRS)

Anderson, R.; Alsid, L.; Carter, V.

1975-01-01

Skylab 190-A photography and LANDSAT-1 analog data have been analyzed to determine coastal wetland mapping potential as a near term substitute for aircraft data and as a long term monitoring tool. The level of detail and accuracy of each was compared. Skylab data provides more accurate classification of wetland types, better delineation of freshwater marshes and more detailed analysis of drainage patterns. LANDSAT-1 analog data is useful for general classification, boundary definition and monitoring of human impact in wetlands.

Astronaut Bruce McCandless shows mockup of occulting disc for Skylab exp.

NASA Image and Video Library

1973-11-23

S73-37251 (23 November 1973) --- Astronaut Bruce McCandless II, left, shows off a mock-up of the occulting disc for the T025 Coronagraph Contamination Measurement Engineering and Technology Experiment to be used by the crewmen of the third manned Skylab mission (Skylab 4), now into their eighth day in Earth orbit. On the right is flight director Neil B. Hutchinson. The men are in the Mission Operations Control Room (MOCR) of the Mission Control Center (MCC) at Johnson Space Center. Photo credit: NASA

Astronaut Owen Garriott reconstitutes pre-packaged container of food

NASA Technical Reports Server (NTRS)

1973-01-01

Scientist-Astronaut Owen K. Garriott, Skylab 3 science pilot, reconstitutes a pre-packaged container of food at the crew quarters ward room table of the Orbital Workshop (OWS) of the Skylab space station cluster. This picture was taken with a hand-held 35mm Nikon camera. Note the knife and fork on the food tray and the utensil with which Garriott stirs the food mixed with water. Skylab is the first manned space program by NASA which affords the crewmen an opportunity to eat with the same type utensils used on Earth.

Skylab SO71/SO72 circadian periodicity experiment. [experimental design and checkout of hardware

NASA Technical Reports Server (NTRS)

Fairchild, M. K.; Hartmann, R. A.

1973-01-01

The circadian rhythm hardware activities from 1965 through 1973 are considered. A brief history of the programs leading to the development of the combined Skylab SO71/SO72 Circadian Periodicity Experiment (CPE) is given. SO71 is the Skylab experiment number designating the pocket mouse circadian experiment, and SO72 designates the vinegar gnat circadian experiment. Final design modifications and checkout of the CPE, integration testing with the Apollo service module CSM 117 and the launch preparation and support tasks at Kennedy Space Center are reported.

In-Flight Lower Body Negative Pressure - Skylab Experiment M092

NASA Technical Reports Server (NTRS)

1973-01-01

This chart details Skylab's In-Flight Lower Body Negative Pressure experiment facility, a medical evaluation designed to monitor changes in astronauts' cardiovascular systems during long-duration space missions. This experiment collected in-flight data for predicting the impairment of physical capacity and the degree of orthostatic intolerance to be expected upon return to Earth. Data to be collected were blood pressure, heart rate, body temperature, vectorcardiogram, lower body negative pressure, leg volume changes, and body mass. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Body Mass Measurement - Skylab Experiment M172

NASA Technical Reports Server (NTRS)

1972-01-01

This chart provides details on Skylab's Body Mass Measurement experiment (M172). The M172 experiment was a medical study to determine the body mass of each crew member and observe changes in body masses during flight. Knowledge of exact body mass variations throughout the flight aided significantly in the correlation of other medical data obtained during the flight. Mass measurements under zero-gravity conditions were achieved by the application of Newton's second law (force equals mass times acceleration). The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows Skylab's Microwave Radiometer/Scatterometer and Altimeter, one of the major components for an Earth Resources Experiment Package (EREP). It was designed to study varying ocean surface, soil erosion, sea and lake ice, snow cover, seasonal vegetational changes, flooding, rainfall and soil types. The overall purpose of the EREP was to test the use of sensors that operated in the visible, infrared, and microwave portions of the electromagnetic spectrum to monitor and study Earth resources. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab 3 crew during training in Orbital Workshop trainer

NASA Technical Reports Server (NTRS)

1973-01-01

The three prime crewmen of the Skylab 3 mission check over flight data during a training session in the crew quarters of the Orbital Workshop (OWS) trainer in the Mission Simulation and Training Facility at JSC. They are from left to right, Scientist-Astronaut Owen K. Garriott, science pilot; and Astronauts Alan L. bean, commander, and Jack R. Lousma, pilot (28419); Skylab 3 crew work with Inflight Medical Support System (IMSS) resupply container atop the food table in the OWS. From left to right are Garriott, Lousma and Bean (28420).

Red cell metabolism studies on Skylab

NASA Technical Reports Server (NTRS)

Mengel, C. E.

1974-01-01

On the basis of these background data, metabolic studies were performed on humans involved in space flight. These studies included the Skylab experiences. The primary purpose of the investigations was to study red cells for: (1) evidences of lipid peroxidation, or (2) changes at various points in the glycolytic pathway. The Skylab missions were an opportunity to study blood samples before, during, and after flight and to compare results with simultaneous controls. No direct evidence that lipid peroxidation had occurred in the red blood cells was apparent in the studies.

Snow covered Alps of France, Italy, and Switzerland

NASA Image and Video Library

1973-07-30

SL3-121-2438 (July-September 1973) --- The Alps of Switzerland, France and Italy are featured in this exceptional photograph taken by a hand-held camera from the Skylab space station during the second manned Skylab mission. Also visible in the out-the-window 70mm Hasselblad view are Lake Geneva, Lake of Lucerne, Rhone River and many other features. The Skylab 3 crewmen, astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma completed a 59-day mission with a successful splashdown on Sept. 25, 1973. Photo credit: NASA

Skylab (SL)-3 Crew - Training - Orbital Workshop Trainer - JSC

NASA Image and Video Library

1973-06-16

S73-28420 (16 June 1973) --- The three prime crewmen of the Skylab 3 mission check over flight data during a training session in the crew quarters of the Orbital Workshop (OWS) trainer in the Mission Simulation and Training Facility at the Johnson Space Center (JSC). Skylab 3 crew work with Inflight Medical Support System (IMSS) resupply container atop the food table in the OWS. They are from left to right, scientist-astronaut Owen K. Garriott, science pilot; and astronauts Jack R. Lousma, pilot; and Alan L. Bean, commander. Photo credit: NASA

Skylab (SL)-3 Crew - Training - Orbital Workshop Trainer - JSC

NASA Image and Video Library

1973-06-16

S73-28419 (16 June 1973) --- The three prime crewmen of the Skylab 3 mission check over flight data during a training session in the crew quarters of the Orbital Workshop (OWS) trainer in the Mission Simulation and Training Facility at the Johnson Space Center (JSC). They are, from left to right, scientist-astronaut Owen K. Garriott, science pilot; and astronauts Alan L. Bean, commander, and Jack R. Lousma, pilot. The 56-day, second manned Skylab Earth-orbital mission is scheduled for liftoff in the latter part of July 1973. Photo credit: NASA

Skylab experiments. Volume 2: Remote sensing of earth resources

NASA Technical Reports Server (NTRS)

1973-01-01

This volume covers the broad area of earth resources in which Skylab experiments will be performed. A brief description of the Skylab program, its objectives, and vehicles is included. Section 1 introduces the concept and historical significance of remote sensing, and discusses the major scientific considerations involved in remotely sensing the earth's resources. Sections 2 through 6 provide a description of the individual earth resource sensors and experiments to be performed. Each description includes a discussion of the experiment background and scientific objectives, the equipment involved, and a discussion of significant experiment performance areas.

Skylab

NASA Image and Video Library

1970-09-01

This 1970 photograph shows Skylab's Dual X-Ray Telescopes, an Apollo Telescope Mount facility. It was designed to gather solar radiation data in the x-ray region of the solar spectrum and provide information on physical processes within the solar atmosphere. In support of the two primary telescopes, auxiliary instruments provided a continuous record of the total x-ray flux in two bands. A flare detector was also provided at the control console as an aid to astronauts for monitoring solar activity. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab

NASA Image and Video Library

1973-01-01

This chart details Skylab's Dual X-Ray Telescopes, one of eight Apollo Telescope Mount facilities. It was designed to gather solar radiation data in the x-ray region of the solar spectrum and provide information on physical processes within the solar atmosphere. In support of the two primary telescopes, auxiliary instruments provided a continuous record of the total x-ray flux in two bands. A flare detector was also provided at the control console as an aid to astronauts for monitoring solar activity. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Skylab beverage container filled with orange juice held by Astronaut Conrad

NASA Technical Reports Server (NTRS)

1973-01-01

An accordian-style beverage dispenser filled with orange juice is held by Astronaut Charles Conrad Jr., Skylab 2 commander, in this close-up view which is a reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. Conrad (head and face not in view) is seated at the wardroom table in the crew quarters of the Orbital Workshop. The dispenser contained beverage crystals, and Conrad has just added the prescribed amount of water to make the orange drink.

Cosolvent-Based Molecular Dynamics for Ensemble Docking: Practical Method for Generating Druggable Protein Conformations.

PubMed

Uehara, Shota; Tanaka, Shigenori

2017-04-24

Protein flexibility is a major hurdle in current structure-based virtual screening (VS). In spite of the recent advances in high-performance computing, protein-ligand docking methods still demand tremendous computational cost to take into account the full degree of protein flexibility. In this context, ensemble docking has proven its utility and efficiency for VS studies, but it still needs a rational and efficient method to select and/or generate multiple protein conformations. Molecular dynamics (MD) simulations are useful to produce distinct protein conformations without abundant experimental structures. In this study, we present a novel strategy that makes use of cosolvent-based molecular dynamics (CMD) simulations for ensemble docking. By mixing small organic molecules into a solvent, CMD can stimulate dynamic protein motions and induce partial conformational changes of binding pocket residues appropriate for the binding of diverse ligands. The present method has been applied to six diverse target proteins and assessed by VS experiments using many actives and decoys of DEKOIS 2.0. The simulation results have revealed that the CMD is beneficial for ensemble docking. Utilizing cosolvent simulation allows the generation of druggable protein conformations, improving the VS performance compared with the use of a single experimental structure or ensemble docking by standard MD with pure water as the solvent.

Multi-Layer Identification of Highly-Potent ABCA1 Up-Regulators Targeting LXRβ Using Multiple QSAR Modeling, Structural Similarity Analysis, and Molecular Docking.

PubMed

Chen, Meimei; Yang, Fafu; Kang, Jie; Yang, Xuemei; Lai, Xinmei; Gao, Yuxing

2016-11-29

In this study, in silico approaches, including multiple QSAR modeling, structural similarity analysis, and molecular docking, were applied to develop QSAR classification models as a fast screening tool for identifying highly-potent ABCA1 up-regulators targeting LXRβ based on a series of new flavonoids. Initially, four modeling approaches, including linear discriminant analysis, support vector machine, radial basis function neural network, and classification and regression trees, were applied to construct different QSAR classification models. The statistics results indicated that these four kinds of QSAR models were powerful tools for screening highly potent ABCA1 up-regulators. Then, a consensus QSAR model was developed by combining the predictions from these four models. To discover new ABCA1 up-regulators at maximum accuracy, the compounds in the ZINC database that fulfilled the requirement of structural similarity of 0.7 compared to known potent ABCA1 up-regulator were subjected to the consensus QSAR model, which led to the discovery of 50 compounds. Finally, they were docked into the LXRβ binding site to understand their role in up-regulating ABCA1 expression. The excellent binding modes and docking scores of 10 hit compounds suggested they were highly-potent ABCA1 up-regulators targeting LXRβ. Overall, this study provided an effective strategy to discover highly potent ABCA1 up-regulators.

Skylab 2 facilities and environmental measurements program

NASA Technical Reports Server (NTRS)

1972-01-01

A list of the facilities and environmental measurements to be monitored in support of the Skylab 2 vehicle is presented. The data include measurement identification number, description, transducer operating range, recorder type, and drawings illustrating measurement location.

MSFC Skylab Kohoutek experiments mission evaluation

NASA Technical Reports Server (NTRS)

1974-01-01

The Comet Kohoutek was documented by the Skylab 4 experiments' observations. The experiment concepts, hardware, operational performance and anomalies are discussed. Experiments which viewed the comet were mainly through the SAL and ATM, but some were handheld and EVA.

Astronaut Gerald Carr floats in forward dome area

NASA Image and Video Library

1974-02-01

Astronaut Gerald P. Carr, commander for the Skylab 4 mission, demonstrates the effects of zero-gravity as he floats in the forward dome area of the Orbital Workshop of the Skylab space station while in Earth orbit.

Skylab's Astronomy and Space Sciences

NASA Technical Reports Server (NTRS)

Lundquist, C. A. (Editor)

1979-01-01

The capabilities of Skylab for multidisciplinary investigations are reviewed. Experiments and results are discussed for observations of stars and galaxies, energetic particles, interplanetary dust, Comet Kohoutek, the earth's atmosphere, and the nature and effects of space environments on man.

View of Skylab space station cluster in Earth orbit from CSM

NASA Image and Video Library

2008-08-18

SL4-143-4706 (8 Feb. 1974) --- An overhead view of the Skylab space station cluster in Earth orbit as photographed from the Skylab 4 Command and Service Modules (CSM) during the final fly-around by the CSM before returning home. The space station is contrasted against a cloud-covered Earth. Note the solar shield which was deployed by the second crew of Skylab and from which a micro meteoroid shield has been missing since the cluster was launched on May 14, 1973. The Orbital Workshop (OWS) solar panel on the left side was also lost on workshop launch day. Inside the Command Module (CM) when this picture was made were astronaut Gerald P. Carr, commander; scientist-astronaut Edward G. Gibson, science pilot; and astronaut William R. Pogue, pilot. The crew used a 70mm hand-held Hasselblad camera to take this photograph. Photo credit: NASA

Plant Growth/Plant Phototropism - Skylab Student Experiment ED-61/62

NASA Technical Reports Server (NTRS)

1973-01-01

This chart describes the Skylab student experiment ED-61, Plant Growth, and experiment ED-62, Plant Phototropism. Two similar proposals were submitted by Joel G. Wordekemper of West Point, Nebraska, and Donald W. Schlack of Downey, California. Wordekemper's experiment (ED-61) was to see how the lack of gravity would affect the growth of roots and stems of plants. Schlack's experiment (ED-62) was to study the effect of light on a seed developing in zero gravity. The growth container of the rice seeds for their experiment consisted of eight compartments arranged in two parallel rows of four. Each had two windowed surfaces to allow periodic photography of the developing seedlings. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

Skylab

NASA Image and Video Library

1972-05-01

This is a wide-angle view of the Orbital Workshop lower level experiment area. In center foreground is the ergometer bicycle. In center background is a litter chair for the Human Vestibular Function experiment (Skylab Experiment M131) and in right background is the Lower Body Negative Pressure System experiment (Skylab Experiment M092). The ergometer bicycle was used for metabolic activity experiments and exercise. The purpose of the Human Vestibular (irner ear) Function experiment was to examine the effect of weightlessness on man's sensitivity and susceptibility to motion rotation, and his perception of orientation. The Lower Body Negative Pressure experiment investigated the relationship between the zero gravity environment and cardiovascular deconditioning. A characteristic of cardiovascular deconditoning is the partial failure of the blood vessels resulting in the excessive pooling of the blood in the legs when a person assumes an erect posture in a gravity field. The Marshall Space Flight Center had the program management responsibility for the development of Skylab hardware and experiments.