Sample records for sld

  1. netCDF Operators for Rapid Analysis of Measured and Modeled Swath-like Data

    NASA Astrophysics Data System (ADS)

    Zender, C. S.

    2015-12-01

    Swath-like data (hereafter SLD) are defined by non-rectangular and/or time-varying spatial grids in which one or more coordinates are multi-dimensional. It is often challenging and time-consuming to work with SLD, including all Level 2 satellite-retrieved data, non-rectangular subsets of Level 3 data, and model data on curvilinear grids. Researchers and data centers want user-friendly, fast, and powerful methods to specify, extract, serve, manipulate, and thus analyze, SLD. To meet these needs, large research-oriented agencies and modeling center such as NASA, DOE, and NOAA increasingly employ the netCDF Operators (NCO), an open-source scientific data analysis software package applicable to netCDF and HDF data. NCO includes extensive, fast, parallelized regridding features to facilitate analysis and intercomparison of SLD and model data. Remote sensing, weather and climate modeling and analysis communities face similar problems in handling SLD including how to easily: 1. Specify and mask irregular regions such as ocean basins and political boundaries in SLD (and rectangular) grids. 2. Bin, interpolate, average, or re-map SLD to regular grids. 3. Derive secondary data from given quality levels of SLD. These common tasks require a data extraction and analysis toolkit that is SLD-friendly and, like NCO, familiar in all these communities. With NCO users can 1. Quickly project SLD onto the most useful regular grids for intercomparison. 2. Access sophisticated statistical and regridding functions that are robust to missing data and allow easy specification of quality control metrics. These capabilities improve interoperability, software-reuse, and, because they apply to SLD, minimize transmission, storage, and handling of unwanted data. While SLD analysis still poses many challenges compared to regularly gridded, rectangular data, the custom analyses scripts SLD once required are now shorter, more powerful, and user-friendly.

  2. Smart Location Database - Service

    EPA Pesticide Factsheets

    The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block group in the United States. Future updates to the SLD will include additional attributes which summarize the relative location efficiency of a block group when compared to other block groups within the same metropolitan region. EPA also plans to periodically update attributes and add new attributes to reflect latest available data. A log of SLD updates is included in the SLD User Guide. See the user guide for a full description of data sources, data currency, and known limitations: https://edg.epa.gov/data/Public/OP/SLD/SLD_userguide.pdf

  3. Smart Location Database - Download

    EPA Pesticide Factsheets

    The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block group in the United States. Future updates to the SLD will include additional attributes which summarize the relative location efficiency of a block group when compared to other block groups within the same metropolitan region. EPA also plans to periodically update attributes and add new attributes to reflect latest available data. A log of SLD updates is included in the SLD User Guide. See the user guide for a full description of data sources, data currency, and known limitations: https://edg.epa.gov/data/Public/OP/SLD/SLD_userguide.pdf

  4. State SLD Identification Policies and Practices

    ERIC Educational Resources Information Center

    Reschly, Daniel J.; Hosp, John L.

    2004-01-01

    Specific learning disabilities (SLD) conceptual definitions and classification criteria were examined through a survey of state education agency (SEA) SLD contact persons in an effort to update information last published in 1996. Most prior trends continued over the last decade. Results showed that SEA SLD classification criteria continue to be…

  5. Update on SLD Engineering Tools Development

    NASA Technical Reports Server (NTRS)

    Miller, Dean R.; Potapczuk, Mark G.; Bond, Thomas H.

    2004-01-01

    The airworthiness authorities (FAA, JAA, Transport Canada) will be releasing a draft rule in the 2006 timeframe concerning the operation of aircraft in a Supercooled Large Droplet (SLD) environment aloft. The draft rule will require aircraft manufacturers to demonstrate that their aircraft can operate safely in an SLD environment for a period of time to facilitate a safe exit from the condition. It is anticipated that aircraft manufacturers will require a capability to demonstrate compliance with this rule via experimental means (icing tunnels or tankers) and by analytical means (ice prediction codes). Since existing icing research facilities and analytical codes were not developed to account for SLD conditions, current engineering tools are not adequate to support compliance activities in SLD conditions. Therefore, existing capabilities need to be augmented to include SLD conditions. In response to this need, NASA and its partners conceived a strategy or Roadmap for developing experimental and analytical SLD simulation tools. Following review and refinement by the airworthiness authorities and other international research partners, this technical strategy has been crystallized into a project plan to guide the SLD Engineering Tool Development effort. This paper will provide a brief overview of the latest version of the project plan and technical rationale, and provide a status of selected SLD Engineering Tool Development research tasks which are currently underway.

  6. Evaluation of NCAR Icing/SLD Forecasts, Tools and Techniques Used During The 1998 NASA SLD Flight Season

    NASA Technical Reports Server (NTRS)

    Bernstein, Ben C.

    2001-01-01

    Supercooled Large Droplet (SLD) icing conditions were implicated in at least one recent aircraft crash, and have been associated with other aircraft incidents. Inflight encounters with SLD can result in ice accreting on unprotected areas of the wing where it can not be removed. Because this ice can adversely affect flight characteristics of some aircraft, there has been concern about flight safety in these conditions. The FAA held a conference on in-flight icing in 1996 where the state of knowledge concerning SLD was explored. One outcome of these meetings was an identified need to acquire SLD flight research data, particularly in the Great Lakes Region. The flight research data was needed by the FAA to develop a better understanding of the meteorological characteristics associated with SLD and facilitate an assessment of existing aircraft icing certification regulations with respect to SLD. In response to this need, NASA, the Federal Aviation Administration (FAA), and the National Center for Atmospheric Research (NCAR) conducted a cooperative icing flight research program to acquire SLD flight research data. The NASA Glenn Research Center's Twin Otter icing research aircraft was flown throughout the Great Lakes region during the winters of 1996-97 and 1997-98 to acquire SLD icing and meteorological data. The NASA Twin Otter was instrumented to measure cloud microphysical properties (particle size, LWC (Liquid Water Content), temperature, etc.), capture images of wing and tail ice accretion, and then record the resultant effect on aircraft performance due to the ice accretion. A satellite telephone link enabled the researchers onboard the Twin Otter to communicate with NCAR meteorologists. who provided real-time guidance into SLD icing conditions. NCAR meteorologists also provided preflight SLD weather forecasts that were used to plan the research flights, and served as on-board researchers. This document contains an evaluation of the tools and techniques NCAR forecasters used to predict the location of SLD icing conditions during the winter of 1997-1998. The objectives of this report are to: (1) assess the tools used to forecast in-flight icing. (2) assess the success/failure rate of the forecasts, and (3) discuss suggested changes to forecast techniques.

  7. Neuropsychological Profiles of Written Expression Learning Disabilities Determined by Concordance-Discordance Model Criteria.

    PubMed

    Fenwick, Melanie E; Kubas, Hanna A; Witzke, Justin W; Fitzer, Kim R; Miller, Daniel C; Maricle, Denise E; Harrison, Gina L; Macoun, Sarah J; Hale, James B

    2016-01-01

    Children with specific learning disabilities (SLD) have disparate neuropsychological processing deficits that interfere with academic achievement in spelling, writing fluency, and/or written expression (WE). Although there are multiple potential causes of WE SLD, there is a paucity of research exploring this critical academic skill from a neuropsychological perspective. This study examined the neuropsychological profiles of WE SLD subtypes defined using the concordance-discordance model (C-DM) of SLD identification. Participants were drawn from a sample of 283 children (194 boys, 89 girls) aged 6 years to 16 years old (M(age) = 9.58 years, SD = 2.29 years) referred for comprehensive neuropsychological evaluations in school settings and subsequently selected based on C-DM determined spelling, writing fluency, and WE SLD. WE SLD subtypes differed on several psychomotor, memory, and executive function measures (F range = 2.48-5.07, p range = .049 to <.001), suggesting that these children exhibit distinct patterns of neuropsychological processing strengths and weaknesses. Findings have relevance for differential diagnosis of WE subtypes, discriminating WE SLD subtypes from low WE achievement, and developing differentiated evidence-based instruction and intervention for children with WE SLD. Limitations and future research will be addressed.

  8. Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition

    DTIC Science & Technology

    2015-09-01

    ARL-CR-0783 ● SEP 2015 US Army Research Laboratory Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid...ARL-CR-0783 ● SEP 2015 US Army Research Laboratory Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle...Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition 5a. CONTRACT NUMBER 1120-1120-99 5b. GRANT NUMBER 5c

  9. Neutrophil-cytokine interactions in a rat model of sulindac-induced idiosyncratic liver injury.

    PubMed

    Zou, Wei; Roth, Robert A; Younis, Husam S; Malle, Ernst; Ganey, Patricia E

    2011-12-18

    Previous studies indicated that lipopolysaccharide (LPS) interacts with the nonsteroidal anti-inflammatory drug sulindac (SLD) to produce liver injury in rats. In the present study, the mechanism of SLD/LPS-induced liver injury was further investigated. Accumulation of polymorphonuclear neutrophils (PMNs) in the liver was greater in SLD/LPS-cotreated rats compared to those treated with SLD or LPS alone. In addition, PMN activation occurred specifically in livers of rats cotreated with SLD/LPS. The hypothesis that PMNs and proteases released from them play critical roles in the hepatotoxicity was tested. SLD/LPS-induced liver injury was attenuated by prior depletion of PMNs or by treatment with the PMN protease inhibitor, eglin C. Previous studies suggested that tumor necrosis factor-α (TNF) and the hemostatic system play critical roles in the pathogenesis of liver injury induced by SLD/LPS. TNF and plasminogen activator inhibitor-1 (PAI-1) can contribute to hepatotoxicity by affecting PMN activation and fibrin deposition. Therefore, the role of TNF and PAI-1 in PMN activation and fibrin deposition in the SLD/LPS-induced liver injury model was tested. Neutralization of TNF or inhibition of PAI-1 attenuated PMN activation. TNF had no effect on PAI-1 production or fibrin deposition. In contrast, PAI-1 contributed to fibrin deposition in livers of rats treated with SLD/LPS. In summary, PMNs, TNF and PAI-1 contribute to the liver injury induced by SLD/LPS cotreatment. TNF and PAI-1 independently contributed to PMN activation, which is critical to the pathogenesis of liver injury. Moreover, PAI-1 contributed to liver injury by promoting fibrin deposition. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  10. Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase

    PubMed Central

    Bruck, Irina; Kaplan, Daniel L.

    2015-01-01

    Dbf4-dependent kinase (DDK) phosphorylates minichromosome maintenance 2 (Mcm2) during S phase in yeast, and Sld3 recruits cell division cycle 45 (Cdc45) to minichromosome maintenance 2-7 (Mcm2-7). We show here DDK-phosphoryled Mcm2 preferentially interacts with Cdc45 in vivo, and that Sld3 stimulates DDK phosphorylation of Mcm2 by 11-fold. We identified a mutation of the replication initiation factor Sld3, Sld3-m16, that is specifically defective in stimulating DDK phosphorylation of Mcm2. Wild-type expression levels of sld3-m16 result in severe growth and DNA replication defects. Cells expressing sld3-m16 exhibit no detectable Mcm2 phosphorylation in vivo, reduced replication protein A-ChIP signal at an origin, and diminished Go, Ichi, Ni, and San association with Mcm2-7. Treslin, the human homolog of Sld3, stimulates human DDK phosphorylation of human Mcm2 by 15-fold. DDK phosphorylation of human Mcm2 decreases the affinity of Mcm5 for Mcm2, suggesting a potential mechanism for helicase ring opening. These data suggest a conserved mechanism for replication initiation: Sld3/Treslin coordinates Cdc45 recruitment to Mcm2-7 with DDK phosphorylation of Mcm2 during S phase. PMID:26305950

  11. Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.

    PubMed

    Bruck, Irina; Kaplan, Daniel L

    2015-09-08

    Dbf4-dependent kinase (DDK) phosphorylates minichromosome maintenance 2 (Mcm2) during S phase in yeast, and Sld3 recruits cell division cycle 45 (Cdc45) to minichromosome maintenance 2-7 (Mcm2-7). We show here DDK-phosphoryled Mcm2 preferentially interacts with Cdc45 in vivo, and that Sld3 stimulates DDK phosphorylation of Mcm2 by 11-fold. We identified a mutation of the replication initiation factor Sld3, Sld3-m16, that is specifically defective in stimulating DDK phosphorylation of Mcm2. Wild-type expression levels of sld3-m16 result in severe growth and DNA replication defects. Cells expressing sld3-m16 exhibit no detectable Mcm2 phosphorylation in vivo, reduced replication protein A-ChIP signal at an origin, and diminished Go, Ichi, Ni, and San association with Mcm2-7. Treslin, the human homolog of Sld3, stimulates human DDK phosphorylation of human Mcm2 by 15-fold. DDK phosphorylation of human Mcm2 decreases the affinity of Mcm5 for Mcm2, suggesting a potential mechanism for helicase ring opening. These data suggest a conserved mechanism for replication initiation: Sld3/Treslin coordinates Cdc45 recruitment to Mcm2-7 with DDK phosphorylation of Mcm2 during S phase.

  12. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gouge, Catherine A.; Christensen, Tim W., E-mail: christensent@ecu.edu

    2010-09-10

    Research highlights: {yields} Drosophila Sld5 interacts with Psf1, PPsf2, and Mcm10. {yields} Haploinsufficiency of Sld5 leads to M-phase delay and genomic instability. {yields} Sld5 is also required for normal S phase progression. -- Abstract: Essential for the normal functioning of a cell is the maintenance of genomic integrity. Failure in this process is often catastrophic for the organism, leading to cell death or mis-proliferation. Central to genomic integrity is the faithful replication of DNA during S phase. The GINS complex has recently come to light as a critical player in DNA replication through stabilization of MCM2-7 and Cdc45 as amore » member of the CMG complex which is likely responsible for the processivity of helicase activity during S phase. The GINS complex is made up of 4 members in a 1:1:1:1 ratio: Psf1, Psf2, Psf3, And Sld5. Here we present the first analysis of the function of the Sld5 subunit in a multicellular organism. We show that Drosophila Sld5 interacts with Psf1, Psf2, and Mcm10 and that mutations in Sld5 lead to M and S phase delays with chromosomes exhibiting hallmarks of genomic instability.« less

  13. Deliberate Integration of Student Leadership Development in Doctor of Pharmacy Programs

    PubMed Central

    Nelson, Michael H.; Bzowyckyj, Andrew S.; Fuentes, David G.; Rosenberg, Ettie; DiCenzo, Robert

    2016-01-01

    The CAPE 2013 Outcomes answered the call for increased student leadership development (SLD) by identifying leadership as a desired curricular goal. To meet this outcome, colleges and schools of pharmacy are advised to first identify a set of SLD competencies aligned with their institution’s mission and goals and then organize these competencies into a SLD framework/model. Student leadership development should be integrated vertically and horizontally within the curriculum in a deliberate and longitudinal manner. It should include all student pharmacists, begin at the point of admission, and extend beyond extracurricular activities. The school’s assessment plan should be aligned with the identified SLD competencies so student learning related to leadership is assessed. To accomplish these recommendations, a positive environment for SLD should be cultivated within the school, including administrative backing and resources, as well as support among the broader faculty for integrating SLD into the curriculum. PMID:26941428

  14. Deliberate Integration of Student Leadership Development in Doctor of Pharmacy Programs.

    PubMed

    Janke, Kristin K; Nelson, Michael H; Bzowyckyj, Andrew S; Fuentes, David G; Rosenberg, Ettie; DiCenzo, Robert

    2016-02-25

    The CAPE 2013 Outcomes answered the call for increased student leadership development (SLD) by identifying leadership as a desired curricular goal. To meet this outcome, colleges and schools of pharmacy are advised to first identify a set of SLD competencies aligned with their institution's mission and goals and then organize these competencies into a SLD framework/model. Student leadership development should be integrated vertically and horizontally within the curriculum in a deliberate and longitudinal manner. It should include all student pharmacists, begin at the point of admission, and extend beyond extracurricular activities. The school's assessment plan should be aligned with the identified SLD competencies so student learning related to leadership is assessed. To accomplish these recommendations, a positive environment for SLD should be cultivated within the school, including administrative backing and resources, as well as support among the broader faculty for integrating SLD into the curriculum.

  15. Verification and Planning Based on Coinductive Logic Programming

    NASA Technical Reports Server (NTRS)

    Bansal, Ajay; Min, Richard; Simon, Luke; Mallya, Ajay; Gupta, Gopal

    2008-01-01

    Coinduction is a powerful technique for reasoning about unfounded sets, unbounded structures, infinite automata, and interactive computations [6]. Where induction corresponds to least fixed point's semantics, coinduction corresponds to greatest fixed point semantics. Recently coinduction has been incorporated into logic programming and an elegant operational semantics developed for it [11, 12]. This operational semantics is the greatest fix point counterpart of SLD resolution (SLD resolution imparts operational semantics to least fix point based computations) and is termed co- SLD resolution. In co-SLD resolution, a predicate goal p( t) succeeds if it unifies with one of its ancestor calls. In addition, rational infinite terms are allowed as arguments of predicates. Infinite terms are represented as solutions to unification equations and the occurs check is omitted during the unification process. Coinductive Logic Programming (Co-LP) and Co-SLD resolution can be used to elegantly perform model checking and planning. A combined SLD and Co-SLD resolution based LP system forms the common basis for planning, scheduling, verification, model checking, and constraint solving [9, 4]. This is achieved by amalgamating SLD resolution, co-SLD resolution, and constraint logic programming [13] in a single logic programming system. Given that parallelism in logic programs can be implicitly exploited [8], complex, compute-intensive applications (planning, scheduling, model checking, etc.) can be executed in parallel on multi-core machines. Parallel execution can result in speed-ups as well as in larger instances of the problems being solved. In the remainder we elaborate on (i) how planning can be elegantly and efficiently performed under real-time constraints, (ii) how real-time systems can be elegantly and efficiently model- checked, as well as (iii) how hybrid systems can be verified in a combined system with both co-SLD and SLD resolution. Implementations of co-SLD resolution as well as preliminary implementations of the planning and verification applications have been developed [4]. Co-LP and Model Checking: The vast majority of properties that are to be verified can be classified into safety properties and liveness properties. It is well known within model checking that safety properties can be verified by reachability analysis, i.e, if a counter-example to the property exists, it can be finitely determined by enumerating all the reachable states of the Kripke structure.

  16. Cognitive Clusters in Specific Learning Disorder.

    PubMed

    Poletti, Michele; Carretta, Elisa; Bonvicini, Laura; Giorgi-Rossi, Paolo

    The heterogeneity among children with learning disabilities still represents a barrier and a challenge in their conceptualization. Although a dimensional approach has been gaining support, the categorical approach is still the most adopted, as in the recent fifth edition of the Diagnostic and Statistical Manual of Mental Disorders. The introduction of the single overarching diagnostic category of specific learning disorder (SLD) could underemphasize interindividual clinical differences regarding intracategory cognitive functioning and learning proficiency, according to current models of multiple cognitive deficits at the basis of neurodevelopmental disorders. The characterization of specific cognitive profiles associated with an already manifest SLD could help identify possible early cognitive markers of SLD risk and distinct trajectories of atypical cognitive development leading to SLD. In this perspective, we applied a cluster analysis to identify groups of children with a Diagnostic and Statistical Manual-based diagnosis of SLD with similar cognitive profiles and to describe the association between clusters and SLD subtypes. A sample of 205 children with a diagnosis of SLD were enrolled. Cluster analyses (agglomerative hierarchical and nonhierarchical iterative clustering technique) were used successively on 10 core subtests of the Wechsler Intelligence Scale for Children-Fourth Edition. The 4-cluster solution was adopted, and external validation found differences in terms of SLD subtype frequencies and learning proficiency among clusters. Clinical implications of these findings are discussed, tracing directions for further studies.

  17. Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation.

    PubMed

    Deegan, Tom D; Yeeles, Joseph Tp; Diffley, John Fx

    2016-05-02

    The initiation of eukaryotic DNA replication requires the assembly of active CMG (Cdc45-MCM-GINS) helicases at replication origins by a set of conserved and essential firing factors. This process is controlled during the cell cycle by cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK), and in response to DNA damage by the checkpoint kinase Rad53/Chk1. Here we show that Sld3, previously shown to be an essential CDK and Rad53 substrate, is recruited to the inactive MCM double hexamer in a DDK-dependent manner. Sld3 binds specifically to DDK-phosphorylated peptides from two MCM subunits (Mcm4, 6) and then recruits Cdc45. MCM mutants that cannot bind Sld3 or Sld3 mutants that cannot bind phospho-MCM or Cdc45 do not support replication. Moreover, phosphomimicking mutants in Mcm4 and Mcm6 bind Sld3 without DDK and facilitate DDK-independent replication. Thus, Sld3 is an essential "reader" of DDK phosphorylation, integrating signals from three distinct protein kinase pathways to coordinate DNA replication during S phase. © 2016 The Authors. Published under the terms of the CC BY 4.0 license.

  18. Optimized nano-transfersomal films for enhanced sildenafil citrate transdermal delivery: ex vivo and in vivo evaluation

    PubMed Central

    Badr-Eldin, Shaimaa M; Ahmed, Osamaa AA

    2016-01-01

    Sildenafil citrate (SLD) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor used for the oral treatment of erectile dysfunction and, more recently, for other indications, including pulmonary hypertension. The challenges facing the oral administration of the drug include poor bioavailability and short duration of action that requires frequent administration. Thus, the objective of this work is to formulate optimized SLD nano-transfersomal transdermal films with enhanced and controlled permeation aiming at surmounting the previously mentioned challenges and hence improving the drug bioavailability. SLD nano-transfersomes were prepared using modified lipid hydration technique. Central composite design was applied for the optimization of SLD nano-transfersomes with minimized vesicular size. The independent variables studied were drug-to-phospholipid molar ratio, surfactant hydrophilic lipophilic balance, and hydration medium pH. The optimized SLD nano-transfersomes were developed and evaluated for vesicular size and morphology and then incorporated into hydroxypropyl methyl cellulose transdermal films. The optimized transfersomes were unilamellar and spherical in shape with vesicular size of 130 nm. The optimized SLD nano-transfersomal films exhibited enhanced ex vivo permeation parameters with controlled profile compared to SLD control films. Furthermore, enhanced bioavailability and extended absorption were demonstrated by SLD nano-transfersomal films as reflected by their significantly higher maximum plasma concentration (Cmax) and area under the curve and longer time to maxi mum plasma concentration (Tmax) compared to control films. These results highlighted the potentiality of optimized SLD nano-transfersomal films to enhance the transdermal permeation and the bioavailability of the drug with the possible consequence of reducing the dose and administration frequency. PMID:27103786

  19. Optimized nano-transfersomal films for enhanced sildenafil citrate transdermal delivery: ex vivo and in vivo evaluation.

    PubMed

    Badr-Eldin, Shaimaa M; Ahmed, Osamaa Aa

    2016-01-01

    Sildenafil citrate (SLD) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor used for the oral treatment of erectile dysfunction and, more recently, for other indications, including pulmonary hypertension. The challenges facing the oral administration of the drug include poor bioavailability and short duration of action that requires frequent administration. Thus, the objective of this work is to formulate optimized SLD nano-transfersomal transdermal films with enhanced and controlled permeation aiming at surmounting the previously mentioned challenges and hence improving the drug bioavailability. SLD nano-transfersomes were prepared using modified lipid hydration technique. Central composite design was applied for the optimization of SLD nano-transfersomes with minimized vesicular size. The independent variables studied were drug-to-phospholipid molar ratio, surfactant hydrophilic lipophilic balance, and hydration medium pH. The optimized SLD nano-transfersomes were developed and evaluated for vesicular size and morphology and then incorporated into hydroxypropyl methyl cellulose transdermal films. The optimized transfersomes were unilamellar and spherical in shape with vesicular size of 130 nm. The optimized SLD nano-transfersomal films exhibited enhanced ex vivo permeation parameters with controlled profile compared to SLD control films. Furthermore, enhanced bioavailability and extended absorption were demonstrated by SLD nano-transfersomal films as reflected by their significantly higher maximum plasma concentration (C max) and area under the curve and longer time to maxi mum plasma concentration (T max) compared to control films. These results highlighted the potentiality of optimized SLD nano-transfersomal films to enhance the transdermal permeation and the bioavailability of the drug with the possible consequence of reducing the dose and administration frequency.

  20. Legal and definitional issues affecting the identification and education of adults with specific learning disabilities in adult education programs.

    PubMed

    Taymans, Juliana M

    2012-01-01

    Although the exact prevalence is not determined, a noticeable subset of individuals who enroll in adult education and training programs have either diagnosed or undiagnosed specific learning disabilities (SLD). Understanding SLD is important basic information for adult educators to inform program policies as well as determine effective instructional practices. This article discusses the development of definitions of SLD and current agreement on the nature of SLD relevant to working with adults. It concludes with implications for adult education programs.

  1. Using Neuropsychometric Measurements in the Differential Diagnosis of Specific Learning Disability

    PubMed Central

    TURGUT TURAN, Sevil; ERDOĞAN BAKAR, Emel; ERDEN, Gülsen; KARAKAŞ, Sirel

    2016-01-01

    Introduction The aim of this study was to develop a neuropsychometric battery for the differential diagnosis of specific learning disability (SLD), with specific respect to attention deficit hyperactivity disorder (ADHD), and to help resolve the conflicting results in the literature by an integrative utilization of scores on both the Bannatyne categories and neuropsychological tests. Methods The sample included 168 primary school boys who were assigned to SLD (n=21), ADHD (n=45), SLD and ADHD (n=57), and control groups (n=45). The exclusion criteria were a neurological or psychiatric comorbidity other than ADHD, a level of anxiety and/or depression above the cutoff score, medication affecting cognitive processes, visual and/or auditory disorders, and an intelligence level outside the IQ range of 85–129. Psychometric scores were obtained from the SLD Battery and Wechsler Intelligence Scale for Children-Revised in the form of Bannatyne category scores. Neuropsychological scores were from the Visual–Aural Digit Span Test-Form B, Serial Digit Learning Test, Judgment of Line Orientation, and Mangina Test. The battery was called the Integrative Battery of SLD. Results The correctness of estimation for classifying cases into the diagnostic dyads (SLD/ADHD, SLD/SLD+ADHD, and SLD+ADHD/ADHD) by an integrative utilization of both the Bannatyne category scores (n=4) and scores from the four neuropsychological tests (n=10) was 92.4%, 81.4%, and 71.8%, respectively. These proportions were generally higher than those obtained using the Bannatyne category scores alone (86.4%, 75.5%, and 73.1%, respectively). The same trend was seen in the classification of children into diagnostic and control groups. However, the proportion of the correctness of estimation was higher than that obtained for the diagnostic dyads. Conclusion When conducted using appropriately chosen research designs and statistical techniques and if confounding variables are sufficiently controlled, a neuropsychometric battery that includes capacities that relate to intelligence (Bannatyne categories) and those that relate to neurocognitive processes (neuropsychological tests) can be useful in the differential diagnosis of SLD. PMID:28360787

  2. On the dynamics of the Sri Lanka Dome in the Bay of Bengal

    NASA Astrophysics Data System (ADS)

    Burns, Jessica M.; Subrahmanyam, Bulusu; Murty, V. S. N.

    2017-09-01

    East of Sri Lanka, in the northern Indian Ocean, a cold dome, known as the Sri Lanka Dome (SLD), develops during southwest monsoon season (June-September). The SLD first forms around May, matures in July, and decays around September, in association with the strong cyclonic wind stress curl. In this study, the structure and dynamics of SLD in response to the climatic events such as the Indian Ocean Dipole (IOD) are examined. Our results reveal that these climatic events modulated the subsurface temperature variability in the thermocline at ˜100 m depth, whose signature was also evident in the satellite-derived sea surface height (SSH) anomaly in the SLD region. We find that the mechanisms for the formation of SLD are consistent with previous research, and there is year-to-year variability in the SLD dynamics. This study also reveals that the atmospheric parameters including vertical wind shear and midtropospheric relative humidity are high over the SLD region and adjacent southern Bay of Bengal and show an upward (increasing) trend over the decades. This has impacted the atmospheric parameters over the northern Bay of Bengal over the decades and as a consequence the total number of monsoon depressions (June-September) decreased over the decades from 1980 to 2015, as reported by the India Meteorological Department, New Delhi. Thus, the new insight emerged from this study is the variability in the cyclogenesis and the occurrence of total number of monsoon depressions over northern Bay of Bengal over the decades is much related to the SLD dynamics.

  3. Freezing Rain as an In-Flight Icing Hazard

    NASA Technical Reports Server (NTRS)

    Bernstein, Ben C.; Ratvasky, Thomas P.; Miller, Dean R.; McDonough, Frank

    2000-01-01

    Exposure to supercooled large drops (SLD-subfreezing water droplets with diameters greater than approx. 50 microns) can pose a significant threat to the safety of some aircraft. Although SLD includes both freezing drizzle (FZDZ) and freezing rain (FZRA), much of the SLD research and development of operational SLD forecast tools has focused on FZDZ and ignored FZRA, regarding is as less of a hazard to aviation. This paper provides a counterpoint case study that demonstrates FZRA as a significant in-flight icing hazard. The case study is based on flight and meteorological data from a joint NASA/FAA/NCAR SLD icing research project collected on February 4, 1998. The NASA Twin Otter Icing Research Aircraft experienced a prolonged exposure to "classical" FZRA that formed extensive ice formations including ridges and nodules on the wing and tail, and resulted in a substantial performance penalty. Although the case study provides only a singular FZRA event with one aircraft type, it is clear that classical FZRA can pose a significant in-flight icing hazard, and should not be ignored when considering SLD issues.

  4. STS-55 German payload specialists pose in front of SL-D2 module at KSC

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, German payload specialists pose in front of the Spacelab Deutsche 2 (SL-D2) science module at a Kennedy Space Center (KSC) processing facility. These two Germans have been assigned to support the STS-55/SL-D2 mission. They are Payload Specialist 2 Hans Schlegel (left) and Payload Specialist 1 Ulrich Walter. Walter and Schlegel are scheduled to fly aboard OV-102 for the mission, joining five NASA astronauts. Clearly visible on the SL-D2 module are the European Space Agency (ESA) insignia, the feedthrough plate, and the D2 insignia.

  5. Validated stability-indicating spectrophotometric methods for the determination of Silodosin in the presence of its degradation products.

    PubMed

    Boltia, Shereen A; Abdelkawy, Mohammed; Mohammed, Taghreed A; Mostafa, Nahla N

    2018-09-05

    Five simple, rapid, accurate, and precise spectrophotometric methods are developed for the determination of Silodosin (SLD) in the presence of its acid induced and oxidative induced degradation products. Method A is based on dual wavelength (DW) method; two wavelengths are selected at which the absorbance of the oxidative induced degradation product is the same, so wavelengths 352 and 377 nm are used to determine SLD in the presence of its oxidative induced degradation product. Method B depends on induced dual wavelength theory (IDW), which is based on selecting two wavelengths on the zero-order spectrum of SLD where the difference in absorbance between them for the spectrum of acid induced degradation products is not equal to zero so through multiplying by the equality factor, the absorption difference is made to be zero for the acid induced degradation product while it is still significant for SLD. Method C is first derivative ( 1 D) spectrophotometry of SLD and its degradation products. Peak amplitudes are measured at 317 and 357 nm. Method D is ratio difference spectrophotometry (RD) where the drug is determined by the difference in amplitude between two selected wavelengths, at 350 and 277 nm for the ratio spectrum of SLD and its acid induced degradation products while for the ratio spectrum of SLD and its oxidative induced degradation products the difference in amplitude is measured at 345 and 292 nm. Method E depends on measuring peak amplitudes of the first derivative of the ratio ( 1 DD) where peak amplitudes are measured at 330 nm in the presence of the acid induced degradation product and measured by peak to peak technique at 326 and 369 nm in the presence of the oxidative induced degradation product. The proposed methods are validated according to ICH recommendations. The calibration curves for all the proposed methods are linear over a concentration range of 5-70 μg/mL. The selectivity of the proposed methods was tested using different laboratory prepared mixtures of SLD with either its acid induced or oxidative induced degradation products showing specificity of SLD with accepted recovery values. The proposed methods have been successfully applied to the analysis of SLD in pharmaceutical dosage forms without interference from additives. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. SLD-MOSCNT: A new MOSCNT with step-linear doping profile in the source and drain regions

    NASA Astrophysics Data System (ADS)

    Tahne, Behrooz Abdi; Naderi, Ali

    2017-01-01

    In this paper, a new structure, step-linear doping MOSCNT (SLD-MOSCNT), is proposed to improve the performance of basic MOSCNTs. The basic structure suffers from band to band tunneling (BTBT). We show that using SLD profile for source and drain regions increases the horizontal distance between valence and conduction bands at gate to source/drain junction which reduces BTBT probability. SLD performance is compared with other similar structures which have recently been proposed to reduce BTBT such as MOSCNT with lightly-doped drain and source (LDDS), and with double-light doping in source and drain regions (DLD). The obtained results using a nonequilibrium Green’s function (NEGF) method show that the SLD-MOSCNT has the lowest leakage current, power consumption and delay time, and the highest current ratio and voltage gain. The ambipolar conduction in the proposed structure is very low and can be neglected. In addition, these structures can improve short-channel effects. Also, the investigation of cutoff frequency of the different structures shows that the SLD has the highest cutoff frequency. Device performance has been investigated for gate length from 8 to 20 nm which demonstrates all discussions regarding the superiority of the proposed structure are also valid for different channel lengths. This improvement is more significant especially for channel length less than 12 nm. Therefore, the SLD can be considered as a candidate to be used in the applications with high speed and low power consumption.

  7. Semi-Empirical Modeling of SLD Physics

    NASA Technical Reports Server (NTRS)

    Wright, William B.; Potapczuk, Mark G.

    2004-01-01

    The effects of supercooled large droplets (SLD) in icing have been an area of much interest in recent years. As part of this effort, the assumptions used for ice accretion software have been reviewed. A literature search was performed to determine advances from other areas of research that could be readily incorporated. Experimental data in the SLD regime was also analyzed. A semi-empirical computational model is presented which incorporates first order physical effects of large droplet phenomena into icing software. This model has been added to the LEWICE software. Comparisons are then made to SLD experimental data that has been collected to date. Results will be presented for the comparison of water collection efficiency, ice shape and ice mass.

  8. Diminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens.

    PubMed

    Leung, F C; Styles, W J; Rosenblum, C I; Lilburn, M S; Marsh, J A

    1987-02-01

    Hepatic growth hormone (GH) receptor binding was compared in normal and sex-linked dwarfs (SLD) from both Hubbard and Cornell strain chickens. At 6, 8, and 20 weeks of age, hepatic GH receptor binding in the Hubbard SLD chickens was significantly lower than that of normal fast-growing birds. At 20 weeks of age, only 2 of 22 SLD chickens in the Hubbard broiler strain showed positive binding at a high enough level to allow for Scatchard analysis. The affinity constants and binding capacities of these two SLD chickens were numerically (but not significantly) lower than those of the normal fast-growing birds. We further examined hepatic GH receptor binding in two closely related White Leghorn strains of chickens that have been maintained as closed breeding populations for many years. We observed no detectable hepatic GH binding in the Cornell SLD chickens (N = 20), as compared to the normal-growing control strain (K strain). In both SLD strains, pretreatment with 4 M MgCl2 did not enhance GH binding, suggesting that there was no endogenous GH binding to the receptor. Based on these data, we suggest that the lack, or greatly reduced number, of GH receptors may be a major contributing factor to the dwarfism observed in these strains.

  9. Development of a pharmacovigilance safety monitoring tool for the rollout of single low-dose primaquine and artemether-lumefantrine to treat Plasmodium falciparum infections in Swaziland: a pilot study.

    PubMed

    Poirot, Eugenie; Soble, Adam; Ntshalintshali, Nyasatu; Mwandemele, Asen; Mkhonta, Nomcebo; Malambe, Calisile; Vilakati, Sibonakaliso; Pan, Sisi; Darteh, Sarah; Maphalala, Gugu; Brown, Joelle; Hwang, Jimee; Pace, Cheryl; Stergachis, Andy; Vittinghoff, Eric; Kunene, Simon; Gosling, Roland

    2016-07-22

    Countries remain reluctant to adopt the 2012 World Health Organization recommendation for single low-dose (0.25 mg/kg) primaquine (SLD PQ) for Plasmodium falciparum transmission-blocking due to concerns over drug-related haemolysis risk, especially among glucose-6-phosphate dehydrogenase-deficient (G6PDd) people, without evidence demonstrating that it can be safely deployed in their settings. Pharmacovigilance methods provide a systematic way of collecting safety data and supporting the rollout of SLD PQ. The Primaquine Roll Out Monitoring Pharmacovigilance Tool (PROMPT), comprising: (1) a standardized form to support the surveillance of possible adverse events following SLD PQ treatment; (2) a patient information card to enhance awareness of known adverse drug reactions of SLD PQ use; and (3) a database compiling recorded information, was developed and piloted. Data on patient characteristics, malaria diagnosis and treatment are collected. Blood samples are taken to measure haemoglobin (Hb) and test for G6PD deficiency. Active follow-up includes a repeat Hb measurement and adverse event monitoring on or near day 7. A 13-month prospective pilot study in two hospital facilities in Swaziland alongside the introduction of SLD PQ generated preliminary evidence on the feasibility and acceptability of PROMPT. PROMPT was well received by nurses as a simple, pragmatic approach to active surveillance of SLD PQ safety data. Of the 102 patients enrolled and administered SLD PQ, none were G6PDd. 93 (91.2 %) returned on or near day 7 for follow-up. Four (4.6 %) patients had falls in Hb ≥25 % from baseline, none of whom presented with signs or symptoms of anaemia. No patient's Hb fell below 7 g/dL and none required a blood transfusion. Of the 11 (11 %) patients who reported an adverse event over the study period, three were considered serious and included two deaths and one hospitalization; none were causally related to SLD PQ. Four non-serious adverse events were considered definitely, probably, or possibly related to SLD PQ. Improved pharmacovigilance to monitor and promote the safety of the WHO recommendation is needed. The successful application of PROMPT demonstrates its potential as an important tool to rapidly generate locally acquired safety data and support pharmacovigilance in resource-limited settings.

  10. An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa.

    PubMed

    Chen, Ingrid; Poirot, Eugenie; Newman, Mark; Kandula, Deepika; Shah, Renee; Hwang, Jimee; Cohen, Justin M; Gosling, Roly; Rooney, Luke

    2015-05-15

    Global ambitions to eliminate malaria are intensifying, underscoring a critical need for transmission blocking tools. In 2012, the WHO recommended the use of 0.25 mg/kg of single low-dose (SLD) primaquine to stop Plasmodium falciparum transmission. To ensure the availability of SLD primaquine to countries in need of this tool, more information on the supply, programmatic, and regulatory barriers to the rollout of SLD primaquine is required. Challenges to the rollout of SLD primaquine in sub-Saharan Africa were established through semi-structured qualitative interviews with three primaquine manufacturers, 43 key informants from Ethiopia, Senegal, Swaziland, Zambia, and Tanzania, and 16 malaria research experts. Sanofi and Remedica are the only two sources of SRA-approved primaquine suitable for procurement by international donors. Neither manufacturer produces primaquine tablet strengths suitable for the transmission blocking indication. In-country key informants revealed that the WHO weight-based recommendation to use SLD primaquine is challenging to implement in actual field settings. Malaria programmes expressed safety concerns of SLD primaquine use in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as well as potential interactions between primaquine and co-morbidities, and drug-drug interactions with HIV and/or tuberculosis treatments. Regulatory processes are a major barrier to the rollout of SLD primaquine, requiring multiple steps at both the country and global level. Despite these barriers, demand for SLD primaquine is growing, and malaria researchers are interested in primaquine deployment through mass screen and treat and/or mass drug administration campaigns. Demand for primaquine as a transmission blocking agent is growing rapidly yet multiple barriers to SLD primaquine use exist. Research is needed to define the therapeutic dose range, which will guide dosing regimens in the field, inform the development of new, lower strength primaquine tablets and/or formulation(s), and allay programmatic safety concerns in individuals with G6PD deficiency. Potential interactions between primaquine and co-morbidities and treatments should be explored. To minimize regulatory delays, countries need to prepare for product registration at an early stage, WHO prequalification for suitable primaquine tablet strengths and/or new formulations should be sought, and in the meanwhile only Stringent Regulatory Authority (SRA)-approved primaquine should be used.

  11. Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression

    PubMed Central

    Sheu, Yi-Jun; Kinney, Justin B.; Stillman, Bruce

    2016-01-01

    Eukaryotic chromosomes initiate DNA synthesis from multiple replication origins in a temporally specific manner during S phase. The replicative helicase Mcm2-7 functions in both initiation and fork progression and thus is an important target of regulation. Mcm4, a helicase subunit, possesses an unstructured regulatory domain that mediates control from multiple kinase signaling pathways, including the Dbf4-dependent Cdc7 kinase (DDK). Following replication stress in S phase, Dbf4 and Sld3, an initiation factor and essential target of Cyclin-Dependent Kinase (CDK), are targets of the checkpoint kinase Rad53 for inhibition of initiation from origins that have yet to be activated, so-called late origins. Here, whole-genome DNA replication profile analysis is used to access under various conditions the effect of mutations that alter the Mcm4 regulatory domain and the Rad53 targets, Sld3 and Dbf4. Late origin firing occurs under genotoxic stress when the controls on Mcm4, Sld3, and Dbf4 are simultaneously eliminated. The regulatory domain of Mcm4 plays an important role in the timing of late origin firing, both in an unperturbed S phase and in dNTP limitation. Furthermore, checkpoint control of Sld3 impacts fork progression under replication stress. This effect is parallel to the role of the Mcm4 regulatory domain in monitoring fork progression. Hypomorph mutations in sld3 are suppressed by a mcm4 regulatory domain mutation. Thus, in response to cellular conditions, the functions executed by Sld3, Dbf4, and the regulatory domain of Mcm4 intersect to control origin firing and replication fork progression, thereby ensuring genome stability. PMID:26733669

  12. Search for charmless hadronic decays of B mesons with the SLAC SLD detector

    NASA Astrophysics Data System (ADS)

    Abe, Kenji; Abe, Koya; Abe, T.; Adam, I.; Akagi, T.; Akimoto, H.; Allen, N. J.; Ash, W. W.; Aston, D.; Baird, K. G.; Baltay, C.; Band, H. R.; Barakat, M. B.; Bardon, O.; Barklow, T. L.; Bashindzhagyan, G. L.; Bauer, J. M.; Bellodi, G.; Benvenuti, A. C.; Bilei, G. M.; Bisello, D.; Blaylock, G.; Bogart, J. R.; Bower, G. R.; Brau, J. E.; Breidenbach, M.; Bugg, W. M.; Burke, D.; Burnett, T. H.; Burrows, P. N.; Byrne, R. M.; Calcaterra, A.; Calloway, D.; Camanzi, B.; Carpinelli, M.; Cassell, R.; Castaldi, R.; Castro, A.; Cavalli-Sforza, M.; Chou, A.; Church, E.; Cohn, H. O.; Coller, J. A.; Convery, M. R.; Cook, V.; Cowan, R. F.; Coyne, D. G.; Crawford, G.; Damerell, C. J.; Danielson, M. N.; Daoudi, M.; de Groot, N.; dell'orso, R.; Dervan, P. J.; de Sangro, R.; Dima, M.; Dong, D. N.; Doser, M.; Dubois, R.; Eisenstein, B. I.; Erofeeva, I.; Eschenburg, V.; Etzion, E.; Fahey, S.; Falciai, D.; Fan, C.; Fernandez, J. P.; Fero, M. J.; Flood, K.; Frey, R.; Gifford, J.; Gillman, T.; Gladding, G.; Gonzalez, S.; Goodman, E. R.; Hart, E. L.; Harton, J. L.; Hasuko, K.; Hedges, S. J.; Hertzbach, S. S.; Hildreth, M. D.; Huber, J.; Huffer, M. E.; Hughes, E. W.; Huynh, X.; Hwang, H.; Iwasaki, M.; Jackson, D. J.; Jacques, P.; Jaros, J. A.; Jiang, Z. Y.; Johnson, A. S.; Johnson, J. R.; Johnson, R. A.; Junk, T.; Kajikawa, R.; Kalelkar, M.; Kamyshkov, Y.; Kang, H. J.; Karliner, I.; Kawahara, H.; Kim, Y. D.; King, M. E.; King, R.; Kofler, R. R.; Krishna, N. M.; Kroeger, R. S.; Langston, M.; Lath, A.; Leith, D. W.; Lia, V.; Lin, C.; Liu, M. X.; Liu, X.; Loreti, M.; Lu, A.; Lynch, H. L.; Ma, J.; Mahjouri, M.; Mancinelli, G.; Manly, S.; Mantovani, G.; Markiewicz, T. W.; Maruyama, T.; Masuda, H.; Mazzucato, E.; McKemey, A. K.; Meadows, B. T.; Menegatti, G.; Messner, R.; Mockett, P. M.; Moffeit, K. C.; Moore, T. B.; Morii, M.; Muller, D.; Murzin, V.; Nagamine, T.; Narita, S.; Nauenberg, U.; Neal, H.; Nussbaum, M.; Oishi, N.; Onoprienko, D.; Osborne, L. S.; Panvini, R. S.; Park, C. H.; Pavel, T. J.; Peruzzi, I.; Piccolo, M.; Piemontese, L.; Pitts, K. T.; Plano, R. J.; Prepost, R.; Prescott, C. Y.; Punkar, G. D.; Quigley, J.; Ratcliff, B. N.; Reeves, T. W.; Reidy, J.; Reinertsen, P. L.; Rensing, P. E.; Rochester, L. S.; Rowson, P. C.; Russell, J. J.; Saxton, O. H.; Schalk, T.; Schindler, R. H.; Schumm, B. A.; Schwiening, J.; Sen, S.; Serbo, V. V.; Shaevitz, M. H.; Shank, J. T.; Shapiro, G.; Sherden, D. J.; Shmakov, K. D.; Simopoulos, C.; Sinev, N. B.; Smith, S. R.; Smy, M. B.; Snyder, J. A.; Staengle, H.; Stahl, A.; Stamer, P.; Steiner, H.; Steiner, R.; Strauss, M. G.; Su, D.; Suekane, F.; Sugiyama, A.; Suzuki, S.; Swartz, M.; Szumilo, A.; Takahashi, T.; Taylor, F. E.; Thom, J.; Torrence, E.; Toumbas, N. K.; Usher, T.; Vannini, C.; Va'vra, J.; Vella, E.; Venuti, J. P.; Verdier, R.; Verdini, P. G.; Wagner, D. L.; Wagner, S. R.; Waite, A. P.; Walston, S.; Watts, S. J.; Weidemann, A. W.; Weiss, E. R.; Whitaker, J. S.; White, S. L.; Wickens, F. J.; Williams, B.; Williams, D. C.; Williams, S. H.; Willocq, S.; Wilson, R. J.; Wisniewski, W. J.; Wittlin, J. L.; Woods, M.; Word, G. B.; Wright, T. R.; Wyss, J.; Yamamoto, R. K.; Yamartino, J. M.; Yang, X.; Yashima, J.; Yellin, S. J.; Young, C. C.; Yuta, H.; Zapalac, G.; Zdarko, R. W.; Zhou, J.

    2000-10-01

    Based on a sample of approximately 500 000 hadronic Z0 decays accumulated between 1993 and 1998, the SLD experiment has set limits on 24 fully charged two-body and quasi-two-body exclusive charmless hadronic decays of B+, B0, and B0s mesons. The precise tracking capabilities of the SLD detector provided for the efficient reduction of combinatoric backgrounds, yielding the most precise available limits for ten of these modes.

  13. The Probable Prevalence and Sociodemographic Characteristics of Specific Learning Disorder in Primary School Children in Edirne.

    PubMed

    Görker, Işık; Bozatli, Leyla; Korkmazlar, Ümran; Yücel Karadağ, Meltem; Ceylan, Cansın; Söğüt, Ceren; Aykutlu, Hasan Cem; Subay, Büşra; Turan, Nesrin

    2017-12-01

    The aim of this study was to research the probable prevalence of Specific Learning Disorder (SLD) in primary school children in Edirne City and the relationships with their sociodemographic characteristics. The sample of our study was composed of 2,174 children who were educated in primary schools in second, third, and fourth grades in the academic year 2013-2014 in Edirne City. The teachers and parents of these children were given Specific Learning Difficulties Symptom Scale, Learning Disabilities Symptoms Checklist (teacher and parent forms), and sociodemographic data forms to fill in. Binary logistic regression analysis was used to assess the risk factors for SLD. Our study revealed that the probable prevalence of SLD was 13.6%; 17% for boys and 10.4% for girls. Reading impairment was 3.6%, writing impairment was 6.9%, and mathematic impairment was 6.5%. We determined that consanguineous marriages, low income, history of neonatal jaundice were found as risks for SLD; born by caesarean, developmental delay of walking, and history of neonatal jaundice were found as risks for mathematic impairment. A history of learning difficulties of parents was a risk factor for forming SLD and subtypes. Our findings were consistent with other study results about the prevalence of SLD. The relationships between the probable prevalence rates and sociodemographic data were discussed.

  14. The Probable Prevalence and Sociodemographic Characteristics of Specific Learning Disorder in Primary School Children in Edirne

    PubMed Central

    GÖRKER, Işık; BOZATLI, Leyla; KORKMAZLAR, Ümran; YÜCEL KARADAĞ, Meltem; CEYLAN, Cansın; SÖĞÜT, Ceren; AYKUTLU, Hasan Cem; SUBAY, Büşra; TURAN, Nesrin

    2017-01-01

    Introduction The aim of this study was to research the probable prevalence of Specific Learning Disorder (SLD) in primary school children in Edirne City and the relationships with their sociodemographic characteristics. Methods The sample of our study was composed of 2,174 children who were educated in primary schools in second, third, and fourth grades in the academic year 2013–2014 in Edirne City. The teachers and parents of these children were given Specific Learning Difficulties Symptom Scale, Learning Disabilities Symptoms Checklist (teacher and parent forms), and sociodemographic data forms to fill in. Binary logistic regression analysis was used to assess the risk factors for SLD. Results Our study revealed that the probable prevalence of SLD was 13.6%; 17% for boys and 10.4% for girls. Reading impairment was 3.6%, writing impairment was 6.9%, and mathematic impairment was 6.5%. We determined that consanguineous marriages, low income, history of neonatal jaundice were found as risks for SLD; born by caesarean, developmental delay of walking, and history of neonatal jaundice were found as risks for mathematic impairment. A history of learning difficulties of parents was a risk factor for forming SLD and subtypes. Conclusion Our findings were consistent with other study results about the prevalence of SLD. The relationships between the probable prevalence rates and sociodemographic data were discussed. PMID:29321709

  15. WISC-IV Intellectual Profiles in Italian Children With Specific Learning Disorder and Related Impairments in Reading, Written Expression, and Mathematics.

    PubMed

    Poletti, Michele

    2016-01-01

    The fifth edition of theDiagnostic and Statistical Manual of Mental Disordersgrouped specific learning disabilities in the single diagnostic category of specific learning disorder (SLD), with specifiers for impairments in reading, written expression, and mathematics. This study aimed at investigating the intellectual profile, assessed with the fourth edition of theWechsler Intelligence Scale for Children(WISC-IV), of 172 children with a diagnosis of SLD, compared to 74 clinical referral controls. WISC-IV intellectual functioning in children with SLD was characterized by a significant discrepancy between general ability and cognitive proficiency (General Ability Index [GAI] > Cognitive Proficiency Index [CPI]), and worse performances on the Similarities, Digit Span, Letter-Number Sequencing, and Coding subtests, supporting models of multiple cognitive deficits at the basis of neurodevelopmental disorders as SLD. GAI was the best and more conservative measure provided by the WISC-IV to identify intellectual functioning in children with SLD, and the intellectual discrepancy between GAI and CPI could be considered a "cognitive sign" for the presence of SLD in a single diagnostic category. Cognitive deficits differed in subtypes of impairment (reading, written expression, and mathematics), supporting their distinction for empirical, educational, and rehabilitative purposes. These findings need further replication in larger samples and in comparison to typically developing children. © Hammill Institute on Disabilities 2014.

  16. Ice Shape Scaling for Aircraft in SLD Conditions

    NASA Technical Reports Server (NTRS)

    Anderson, David N.; Tsao, Jen-Ching

    2008-01-01

    This paper has summarized recent NASA research into scaling of SLD conditions with data from both SLD and Appendix C tests. Scaling results obtained by applying existing scaling methods for size and test-condition scaling will be reviewed. Large feather growth issues, including scaling approaches, will be discussed briefly. The material included applies only to unprotected, unswept geometries. Within the limits of the conditions tested to date, the results show that the similarity parameters needed for Appendix C scaling also can be used for SLD scaling, and no additional parameters are required. These results were based on visual comparisons of reference and scale ice shapes. Nearly all of the experimental results presented have been obtained in sea-level tunnels. The currently recommended methods to scale model size, icing limit and test conditions are described.

  17. STS-55 German payload specialists and backups pose in front of SL-D2 at KSC

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, German payload specialists and backup (alternate) payload specialists pose in front of the Spacelab Deutsche 2 (SL-D2) science module at a Kennedy Space Center (KSC) processing facility. These four Germans have been assigned to support the STS-55/SL-D2 mission. Left to right are Payload Specialist 2 Hans Schlegel, backup Payload Specialist Dr. P. Gerhard Thiele (kneeling), Payload Specialist 1 Ulrich Walter, and backup Payload Specialist Renate Brummer. Walter and Schlegel are scheduled to fly aboard OV-102 for the mission while Brummer and Thiele will serve as alternates and fill supportive roles on the ground. Clearly visible on the SL-D2 module are the European Space Agency (ESA) insignia, the feedthrough plate, and the D2 insignia.

  18. Inhibitory and excitatory amino acid neurotransmitters are utilized by the projection from the dorsal deep mesencephalic nucleus to the sublaterodorsal nucleus REM sleep induction zone

    PubMed Central

    Liang, Chang-Lin; Nguyen, Tin Quang; Marks, Gerald A.

    2014-01-01

    The sublaterodorsal nucleus (SLD) in the pons of the rat is a locus supporting short-latency induction of a REM sleep-like state following local application of a GABAA receptor antagonist or kainate, glutamate receptor agonist. One putatively relevant source of these neurotransmitters is from the region of the deep mesencephalic nucleus (DpMe) just ventrolateral to the periaquiductal gray, termed the dorsal DpMe (dDpMe). Here, the amino acid neurotransmitter innervation of SLD from dDpMe was studied utilizing anterograde tract-tracing with biotinylated dextranamine (BDA) and fluorescence immunohistochemistry visualized with laser scanning confocal microscopy. Both markers for inhibitory and excitatory amino acid neurotransmitters were found in varicose axon fibers in SLD originating from dDpMe. Vesicular glutamate transporter2 (VGLUT2) represented the largest number of anterogradely labeled varicosities followed by vesicular GABA transporter (VGAT). Numerous VGAT and VGLUT2 labeled varicosities were observed apposed to dDpMe-labeled axon fibers indicating both excitatory and inhibitory presynaptic, local modulation within the SLD. Some double-labeled BDA/VGAT varicosities were seen apposed to small somata labeled for glutamate consistent with being presynaptic to the phenotype of REM sleep-active SLD neurons. Results found support the current theoretical framework of the interaction of dDpMe and SLD in control of REM sleep, while also indicating operation of mechanisms with a greater level of complexity. PMID:24751569

  19. Integrative Analyses of miRNA-mRNA Interactions Reveal let-7b, miR-128 and MAPK Pathway Involvement in Muscle Mass Loss in Sex-Linked Dwarf Chickens

    PubMed Central

    Luo, Wen; Lin, Shumao; Li, Guihuan; Nie, Qinghua; Zhang, Xiquan

    2016-01-01

    The sex-linked dwarf (SLD) chicken is an ideal model system for understanding growth hormone (GH)-action and growth hormone receptor (GHR) function because of its recessive mutation in the GHR gene. Skeletal muscle mass is reduced in the SLD chicken with a smaller muscle fiber diameter. Our previous study has presented the mRNA and miRNA expression profiles of the SLD chicken and normal chicken between embryo day 14 and seven weeks of age. However, the molecular mechanism of GHR-deficient induced muscle mass loss is still unclear, and the key molecules and pathways underlying the GHR-deficient induced muscle mass loss also remain to be illustrated. Here, by functional network analysis of the differentially expressed miRNAs and mRNAs between the SLD and normal chickens, we revealed that let-7b, miR-128 and the MAPK pathway might play key roles in the GHR-deficient induced muscle mass loss, and that the reduced cell division and growth are potential cellular processes during the SLD chicken skeletal muscle development. Additionally, we also found some genes and miRNAs involved in chicken skeletal muscle development, through the MAPK, PI3K-Akt, Wnt and Insulin signaling pathways. This study provides new insights into the molecular mechanism underlying muscle mass loss in the SLD chickens, and some regulatory networks that are crucial for chicken skeletal muscle development. PMID:26927061

  20. Acquisition of second-line drug resistance and extensive drug resistance during recent transmission of Mycobacterium tuberculosis in rural China.

    PubMed

    Hu, Y; Mathema, B; Zhao, Q; Chen, L; Lu, W; Wang, W; Kreiswirth, B; Xu, B

    2015-12-01

    Multidrug-resistant tuberculosis (MDR-TB) is prevalent in countries with a high TB burden, like China. As little is known about the emergence and spread of second-line drug (SLD) -resistant TB, we investigate the emergence and transmission of SLD-resistant Mycobacterium tuberculosis in rural China. In a multi-centre population-based study, we described the bacterial population structure and the transmission characteristics of SLD-resistant TB using Spoligotyping in combination with genotyping based on 24-locus MIRU-VNTR (mycobacterial interspersed repetitive unit-variable-number tandem repeat) plus four highly variable loci for the Beijing family, in four rural Chinese regions with diverse geographic and socio-demographic characteristics. Transmission networks among genotypically clustered patients were constructed using social network analysis. Of 1332 M. tuberculosis patient isolates recovered, the Beijing family represented 74.8% of all isolates and an association with MDR and simultaneous resistance between first-line drugs and SLDs. The genotyping analysis revealed that 189 isolates shared MIRU-VNTR patterns in 78 clusters with clustering rate and recent transmission rate of 14.2% and 8.3%, respectively. Fifty-three SLD-resistant isolates were observed in 31 clusters, 30 of which contained the strains with different drug susceptibility profiles and genetic mutations. In conjunction with molecular data, socio-network analysis indicated a key role of Central Township in the transmission across a highly interconnected network where SLD resistance accumulation occurred during transmission. SLD-resistant M. tuberculosis has been spreading in rural China with Beijing family being the dominant strains. Primary transmission of SLD-resistant strains in the population highlights the importance of routine drug susceptibility testing and effective anti-tuberculosis regimens for drug-resistant TB. Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  1. NJDOT Transportation Data User Survey

    DOT National Transportation Integrated Search

    2010-02-01

    The New Jersey Straight Line Diagrams (SLD) is the main reference for the State's centerline roadway inventory. SLD was initially designed as a planning tool, but it has become a standard information platform for many other purposes within and outsid...

  2. Walkability Index

    EPA Pesticide Factsheets

    The Walkability Index dataset characterizes every Census 2010 block group in the U.S. based on its relative walkability. Walkability depends upon characteristics of the built environment that influence the likelihood of walking being used as a mode of travel. The Walkability Index is based on the EPA's previous data product, the Smart Location Database (SLD). Block group data from the SLD was the only input into the Walkability Index, and consisted of four variables from the SLD weighted in a formula to create the new Walkability Index. This dataset shares the SLD's block group boundary definitions from Census 2010. The methodology describing the process of creating the Walkability Index can be found in the documents located at ftp://newftp.epa.gov/EPADataCommons/OP/WalkabilityIndex.zip. You can also learn more about the Smart Location Database at https://edg.epa.gov/data/Public/OP/Smart_Location_DB_v02b.zip.

  3. Insights into the Initiation of Eukaryotic DNA Replication.

    PubMed

    Bruck, Irina; Perez-Arnaiz, Patricia; Colbert, Max K; Kaplan, Daniel L

    2015-01-01

    The initiation of DNA replication is a highly regulated event in eukaryotic cells to ensure that the entire genome is copied once and only once during S phase. The primary target of cellular regulation of eukaryotic DNA replication initiation is the assembly and activation of the replication fork helicase, the 11-subunit assembly that unwinds DNA at a replication fork. The replication fork helicase, called CMG for Cdc45-Mcm2-7, and GINS, assembles in S phase from the constituent Cdc45, Mcm2-7, and GINS proteins. The assembly and activation of the CMG replication fork helicase during S phase is governed by 2 S-phase specific kinases, CDK and DDK. CDK stimulates the interaction between Sld2, Sld3, and Dpb11, 3 initiation factors that are each required for the initiation of DNA replication. DDK, on the other hand, phosphorylates the Mcm2, Mcm4, and Mcm6 subunits of the Mcm2-7 complex. Sld3 recruits Cdc45 to Mcm2-7 in a manner that depends on DDK, and recent work suggests that Sld3 binds directly to Mcm2-7 and also to single-stranded DNA. Furthermore, recent work demonstrates that Sld3 and its human homolog Treslin substantially stimulate DDK phosphorylation of Mcm2. These data suggest that the initiation factor Sld3/Treslin coordinates the assembly and activation of the eukaryotic replication fork helicase by recruiting Cdc45 to Mcm2-7, stimulating DDK phosphorylation of Mcm2, and binding directly to single-stranded DNA as the origin is melted.

  4. Latest Developments in SLD Scaling

    NASA Technical Reports Server (NTRS)

    Tsao, Jen-Ching; Anderson, David N.

    2006-01-01

    Scaling methods have been shown previously to work well for super cooled large droplet (SLD) main ice shapes. However, feather sizes for some conditions have not been well represented by scale tests. To determine if there are fundamental differences between the development of feathers for appendix C and SLD conditions, this study used time-sequenced photographs, viewing along the span of the model during icing sprays. An airspeed of 100 kt, cloud water drop MVDs of 30 and 140 microns, and stagnation freezing fractions of 0.30 and 0.50 were tested in the NASA Glenn Icing Research Tunnel using an unswept 91-cm-chord NACA0012 airfoil model mounted at 0deg AOA. The photos indicated that the feathers that developed in a distinct region downstream of the leading-edge ice determined the horn location and angle. The angle at which feathers grew from the surface were also measured; results are shown for an airspeed of 150 kt, an MVD of 30 microns, and stagnation freezing fractions of 0.30 to 0.60. Feather angles were found to depend strongly on the stagnation freezing fraction, and were independent of either chordwise position on the model or time into the spray. Feather angles also correlated well with horn angles. For these tests, there did not appear to be fundamental differences between the physics of SLD and appendix C icing; therefore, for these conditions similarity parameters used for appendix C scaling appear to be valid for SLD scaling as well. Further investigation into the cause for the large feather structures observed for some SLD conditions will continue.

  5. Differences in the intellectual profile of children with intellectual vs. learning disability.

    PubMed

    Cornoldi, Cesare; Giofrè, David; Orsini, Arturo; Pezzuti, Lina

    2014-09-01

    The WISC-IV was used to compare the intellectual profile of two groups of children, one with specific learning disorders (SLDs), the other with intellectual disabilities (ID), with a view to identifying which of the four main factor indexes and two additional indexes can distinguish between the groups. We collected information on WISC-IV scores for 267 children (Mage=10.61 [SD=2.51], range 6-16 years, females=99) with a diagnosis of either SLD or ID. Children with SLD performed better than those with ID in all measures. Only the SLD children, not the ID children, revealed significant differences in the four main factor indexes, and their scores for the additional General Ability Index (GAI) were higher than for the Cognitive Proficiency Index (CPI). Children with a diagnosis of SLD whose Full-Scale Intelligence Quotient (FSIQ) was <85 showed a similar pattern. Our findings confirm the hypothesis that children with SLD generally obtain high GAI scores, but have specific deficiencies relating to working memory and processing speed, whereas children with ID have a general intellectual impairment. These findings have important diagnostic and clinical implications and should be considered when making diagnostic decisions in borderline cognitive cases. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Past Accomplishments and Future Challenges

    ERIC Educational Resources Information Center

    Danielson, Louis; Doolittle, Jennifer; Bradley, Renee

    2005-01-01

    Three broad issues continue to dramatically impact the education of children with specific learning disabilities (SLD): (1) the development and implementation of scientifically defensible methods of identification; (2) the development and implementation of scientific interventions to ensure that children with SLD have access to and make progress…

  7. Perspectives on the rapid eye movement sleep switch in rapid eye movement sleep behavior disorder.

    PubMed

    Ramaligam, Vetrivelan; Chen, Michael C; Saper, Clifford B; Lu, Jun

    2013-08-01

    Rapid eye movement (REM) sleep in mammals is associated with wakelike cortical and hippocampal activation and concurrent postural muscle atonia. Research during the past 5 decades has revealed the details of the neural circuitry regulating REM sleep and muscle atonia during this state. REM-active glutamatergic neurons in the sublaterodorsal nucleus (SLD) of the dorsal pons are critical for generation for REM sleep atonia. Descending projections from SLD glutamatergic neurons activate inhibitory premotor neurons in the ventromedial medulla (VMM) and in the spinal cord to antagonize the glutamatergic supraspinal inputs on the motor neurons during REM sleep. REM sleep behavior disorder (RBD) consists of simple behaviors (i.e., twitching, jerking) and complex behaviors (i.e., defensive behavior, talking). Animal research has lead to the hypothesis that complex behaviors in RBD are due to SLD pathology, while simple behaviors of RBD may be due to less severe SLD pathology or dysfunction of the VMM, ventral pons, or spinal cord. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Identifying Specific Learning Disabilities: Legislation, Regulation, and Court Decisions

    ERIC Educational Resources Information Center

    Zumeta, Rebecca O.; Zirkel, Perry A.; Danielson, Louis

    2014-01-01

    Specific learning disability (SLD) identification and eligibility practices are evolving and sometimes contentious. This article describes the historical context and current status of the SLD definition, legislation, regulation, and case law related to the identification of students eligible for special education services. The first part traces…

  9. State Laws for RTI: An Updated Snapshot

    ERIC Educational Resources Information Center

    Zirkel, Perry A.; Thomas, Lisa B.

    2010-01-01

    Professionally, and ultimately legally, the definition of "specific learning disabilities" (SLD) has been "a long-standing source of controversy, conflict, and crisis." Yet students with SLD continue to be more numerous by far than any other group receiving special education services. The long-time controversy concerning the…

  10. From Discrepancy to Consistency: Improving SLD Eligibility Guidelines

    ERIC Educational Resources Information Center

    Watson, Kristin

    2017-01-01

    This article explains a process for improving specific learning disabilities (SLD) eligibility guidelines in a special education cooperative in Nebraska. The Central Nebraska Support Services Program (CNSSP) is a special education cooperative that serves four public school districts and seven parochial schools in central Nebraska. Children birth…

  11. Specific Learning Disorders: A Look Inside Children's and Parents' Psychological Well-Being and Relationships.

    PubMed

    Bonifacci, Paola; Storti, Michele; Tobia, Valentina; Suardi, Alessandro

    2016-09-01

    Despite their ascertained neurobiological origin, specific learning disorders (SLD) often have been found to be associated with some emotional disturbances in children, and there is growing interest in the environmental and contextual variables that may modulate children's developmental trajectories. The present study was aimed at evaluating the psychological profile of parents and children and the relationships between their measures. Parents of children with SLD (17 couples, 34 participants) and parents of children with typical development (17 couples, 34 participants) were administered questionnaires assessing parenting styles, reading history, parenting stress, psychopathological indexes, and evaluations of children's anxiety and depression. Children (N = 34, 10.7 ± 1.2 years) were assessed with self-evaluation questionnaires on anxiety, depression, and self-esteem and with a scale assessing their perception of parents' qualities. Results showed that parents of children with SLD have higher parental distress, poorer reading history, and different parenting styles compared to parents of children with TD; there were no differences in psychopathological indexes. The SLD group also rated their children as more anxious and depressed. Children with SLD had lower scholastic and interpersonal self-esteem, but they report ratings of parents' qualities similar to those of TD children. Relationships between parents' and children's measures were further explored. Implications for research and practice are discussed. © Hammill Institute on Disabilities 2015.

  12. Numerical investigation on super-cooled large droplet icing of fan rotor blade in jet engine

    NASA Astrophysics Data System (ADS)

    Isobe, Keisuke; Suzuki, Masaya; Yamamoto, Makoto

    2014-10-01

    Icing (or ice accretion) is a phenomenon in which super-cooled water droplets impinge and accrete on a body. It is well known that ice accretion on blades and vanes leads to performance degradation and has caused severe accidents. Although various anti-icing and deicing systems have been developed, such accidents still occur. Therefore, it is important to clarify the phenomenon of ice accretion on an aircraft and in a jet engine. However, flight tests for ice accretion are very expensive, and in the wind tunnel it is difficult to reproduce all climate conditions where ice accretion can occur. Therefore, it is expected that computational fluid dynamics (CFD), which can estimate ice accretion in various climate conditions, will be a useful way to predict and understand the ice accretion phenomenon. On the other hand, although the icing caused by super-cooled large droplets (SLD) is very dangerous, the numerical method has not been established yet. This is why SLD icing is characterized by splash and bounce phenomena of droplets and they are very complex in nature. In the present study, we develop an ice accretion code considering the splash and bounce phenomena to predict SLD icing, and the code is applied to a fan rotor blade. The numerical results with and without the SLD icing model are compared. Through this study, the influence of the SLD icing model is numerically clarified.

  13. Executive Functioning and Psychopathology in Psychotherapy for Adolescents with Specific Learning Disorders

    ERIC Educational Resources Information Center

    Kopelman-Rubin, Daphne; Klomek, Anat Brunstein; Al-Yagon, Michal; Mufson, Laura; Apter, Alan; Mikulincer, Mario

    2017-01-01

    This study examined the contribution of executive functioning (EF) to improvements in psychiatric symptomatology following I Can Succeed (ICS; Kopelman-Rubin, 2012) psychotherapy, a skill-enhancement intervention designed to target EF and socio-emotional aspects of specific learning disabilities (SLD). Forty adolescents with SLD underwent ICS in…

  14. Splitter board for steamer tube readout at the SLD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bacchetta, N.; Bisello, D.; Castro, A.

    1989-10-01

    This paper presents a controller board designed as a part of the data acquisition system for the readout of limited streamer tube strips in the warm iron calorimeter for the SLD detector. The board controls the data readout and allows for remote setting and diagnostic of the system.

  15. RTI and Other Approaches to SLD Identification under the IDEA: A Legal Update

    ERIC Educational Resources Information Center

    Zirkel, Perry A.

    2017-01-01

    This article provides a concise and objective synthesis of the federal legislation, regulations, and agency policy interpretations; state laws; and case law, including hearing officer and complaint investigation decisions, concerning specific learning disability (SLD) identification since the 2006 IDEA regulations. The results reveal wide latitude…

  16. Career Ambitions: A Comparison of Youth with and without SLD

    ERIC Educational Resources Information Center

    Kortering, Larry J.; Braziel, Patricia M.; McClannon, Terry W.

    2010-01-01

    Participants with and without specific learning disabilities (SLD) provided responses as to background and school features, postschool plans, dream career, and most likely job after completing school. Findings suggest that participant groups are similar across most background and school features, with apparent differences for grade level and…

  17. Psychosocial and Adaptive Deficits Associated with Learning Disability Subtypes

    ERIC Educational Resources Information Center

    Backenson, Erica M.; Holland, Sara C.; Kubas, Hanna A.; Fitzer, Kim R.; Wilcox, Gabrielle; Carmichael, Jessica A.; Fraccaro, Rebecca L.; Smith, Amanda D.; Macoun, Sarah J.; Harrison, Gina L.; Hale, James B.

    2015-01-01

    Children with specific learning disabilities (SLD) have deficits in the basic psychological processes that interfere with learning and academic achievement, and for some SLD subtypes, these deficits can also lead to emotional and/or behavior problems. This study examined psychosocial functioning in 123 students, aged 6 to 11, who underwent…

  18. Self-Disclosure Decisions of University Students with Learning Disabilities

    ERIC Educational Resources Information Center

    Cole, Emma V.; Cawthon, Stephanie W.

    2015-01-01

    The number of students with learning disabilities (SLD) at postsecondary institutions has tripled over the past three decades and now constitutes about 11% of undergraduate students (Joyce & Rossen, 2006; U.S. Department of Education, 2013). Research has found that SLD who use accommodations at their postsecondary institution are more…

  19. A Dynamic Ensemble for Second Language Research: Putting Complexity Theory into Practice

    ERIC Educational Resources Information Center

    Hiver, Phil; Al-Hoorie, Ali H.

    2016-01-01

    In this article, we introduce a template of methodological considerations, termed "the dynamic ensemble," for scholars doing or evaluating empirical second language development (SLD) research within a complexity/dynamic systems theory (CDST) framework. Given that CDST principles have yielded significant insight into SLD and have become…

  20. Second Line of Defense, Port of Buenos Aires and Exolgan Container Terminal Operational Testing and Evaluation Plan, Buenos Aires, Argentina

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roberts, Bryan W.

    2012-08-23

    The Office of the Second Line of Defense (SLD) Megaports project team for Argentina will conduct operational testing and evaluation (OT&E) at Exolgan Container Terminal at the Port of Dock Sud from July 16-20, 2012; and at the Port of Buenos Aires from September 3-7, 2012. SLD is installing radiation detection equipment to screen export, import, and transshipment containers at these locations. The purpose of OT&E is to validate and baseline an operable system that meets the SLD mission and to ensure the system continues to perform as expected in an operational environment with Argentina Customs effectively adjudicating alarms.

  1. Combining RTI and Psychoeducational Assessment: What We Must Assume to Do Otherwise

    ERIC Educational Resources Information Center

    Wodrich, David L.; Spencer, Marsha L. S.; Daley, Kelly B.

    2006-01-01

    The Individuals With Disabilities Education Improvement Act of 2004 (IDEA; 2004) permitted lack of students' response to intervention (RTI) to be considered as a basis for documenting specific learning disabilities (SLD). The previous method of detecting SLD, which relied on IQ and achievement testing, consequently is no longer mandatory.…

  2. Responsiveness to Intervention: An SLD Determination Resource. Information Digest. Winter 2007

    ERIC Educational Resources Information Center

    Tollefson, Julie M.; Mellard, Daryl F.; McKnight, Melinda A.

    2007-01-01

    The 2004 reauthorization of the Individuals with Disabilities Education Improvement Act (P.L. 108-446) (IDEA 2004) has brought the issue of specific learning disabilities (SLD) identification procedures and criteria to the forefront. Calls for reform are not new and are based on decades of various policy, implementation, and research agendas. The…

  3. When Theory Trumps Science: A Critique of the PSW Model for SLD Identification

    ERIC Educational Resources Information Center

    McGill, Ryan J.; Busse, R. T.

    2017-01-01

    There has been vigorous debate within the state of California and elsewhere as to what constitutes appropriate procedures for determining whether an individual qualifies for special education and related services under the category of specific learning disability (SLD). Within the professional literature, there is growing support for educational…

  4. A Rejoinder on the PSW Model for SLD Identification: Still Concerned

    ERIC Educational Resources Information Center

    McGill, Ryan J.; Busse, R. T.

    2017-01-01

    We address Christo, D'Incau, and Ponzuric's response to our original contribution to this journal "When theory trumps science: A critique of the PSW model for SLD identification." Christo and colleagues stated that there is an empirical support for pattern of strengths and weaknesses (PSW) procedures as a component in the identification…

  5. Differences of Articulation Rate and Utterance Length in Fluent and Disfluent Utterances of Preschool Children Who Stutter

    ERIC Educational Resources Information Center

    Chon, HeeCheong; Sawyer, Jean; Ambrose, Nicoline G.

    2012-01-01

    Purpose: The purpose of this study was to investigate characteristics of four types of utterances in preschool children who stutter: perceptually fluent, containing normal disfluencies (OD utterance), containing stuttering-like disfluencies (SLD utterance), and containing both normal and stuttering-like disfluencies (SLD+OD utterance).…

  6. Greek Young Adults with Specific Learning Disabilities Seeking Learning Assessments

    ERIC Educational Resources Information Center

    Bonti, Eleni; Bampalou, Christina E.; Kouimtzi, Eleni M.; Kyritsis, Zacharias

    2018-01-01

    The purpose of this study is to investigate the reasons why Greek young adults with Specific Learning Disabilities (SLD) seek learning assessments. The study sample consisted of 106 adults meeting Diagnostic and Statistical Manual of Mental Disorders criteria for SLD. Data were collected through self-report records (clinical interview) of adults…

  7. Understanding Impulsivity among Children with Specific Learning Disabilities in Inclusion Schools

    ERIC Educational Resources Information Center

    Al-Dababneh, Kholoud Adeeb; Al-Zboon, Eman K.

    2018-01-01

    Impulsive behavior is a characteristic of children with specific learning disabilities (SLD), and is related to learning ability. The present study aims to identify impulsivity behavior in children with SLD who attend inclusion schools, from their resource room teachers' perspectives. A 31-item questionnaire that addressed four subscales was…

  8. The Impact of Affiliate Stigma on the Psychological Well-Being of Mothers of Children with Specific Learning Disabilities in India: The Mediating Role of Subjective Burden.

    PubMed

    Banga, Gazal; Ghosh, Subharati

    2017-09-01

    Knowledge of the impact of affiliate stigma on the wellbeing of caregivers to children with specific learning disability (SLD) in India is limited. To fill in this gap in knowledge a cross-sectional quantitative study was undertaken to assess the impact of affiliate stigma on the psychological well-being of mothers with children with SLD in India, and test the mediating role of subjective burden, using an adapted version of Pearlin's stress and adaptation model. Sample included 100 mothers of children with SLD. Data was collected using a structured interview schedule. Descriptive statistics, correlation and stepwise regression were used as the primary analytic tools. Affiliate stigma experienced by mothers significantly predicted low levels of psychological well-being and subjective burden mediated the relationship between affiliate stigma and psychological wellbeing. The findings call for developing targeted interventions to address affiliate stigma and positive appraisal of the caregiving situation, with the goal of improving the psychological well-being of mothers of children with SLD. © 2016 John Wiley & Sons Ltd.

  9. Visual Analytics Tools for Sustainable Lifecycle Design: Current Status, Challenges, and Future Opportunities.

    PubMed

    Ramanujan, Devarajan; Bernstein, William Z; Chandrasegaran, Senthil K; Ramani, Karthik

    2017-01-01

    The rapid rise in technologies for data collection has created an unmatched opportunity to advance the use of data-rich tools for lifecycle decision-making. However, the usefulness of these technologies is limited by the ability to translate lifecycle data into actionable insights for human decision-makers. This is especially true in the case of sustainable lifecycle design (SLD), as the assessment of environmental impacts, and the feasibility of making corresponding design changes, often relies on human expertise and intuition. Supporting human sense-making in SLD requires the use of both data-driven and user-driven methods while exploring lifecycle data. A promising approach for combining the two is through the use of visual analytics (VA) tools. Such tools can leverage the ability of computer-based tools to gather, process, and summarize data along with the ability of human-experts to guide analyses through domain knowledge or data-driven insight. In this paper, we review previous research that has created VA tools in SLD. We also highlight existing challenges and future opportunities for such tools in different lifecycle stages-design, manufacturing, distribution & supply chain, use-phase, end-of-life, as well as life cycle assessment. Our review shows that while the number of VA tools in SLD is relatively small, researchers are increasingly focusing on the subject matter. Our review also suggests that VA tools can address existing challenges in SLD and that significant future opportunities exist.

  10. A comparison of East Asian summer monsoon simulations from CAM3.1 with three dynamic cores

    NASA Astrophysics Data System (ADS)

    Wei, Ting; Wang, Lanning; Dong, Wenjie; Dong, Min; Zhang, Jingyong

    2011-12-01

    This paper examines the sensitivity of CAM3.1 simulations of East Asian summer monsoon (EASM) to the choice of dynamic cores using three long-term simulations, one with each of the following cores: the Eulerian spectral transform method (EUL), semi-Lagrangian scheme (SLD) and finite volume approach (FV). Our results indicate that the dynamic cores significantly influence the simulated fields not only through dynamics, such as wind, but also through physical processes, such as precipitation. Generally speaking, SLD is superior to EUL and FV in simulating the climatological features of EASM and its interannual variability. The SLD version of the CAM model partially reduces its known deficiency in simulating the climatological features of East Asian summer precipitation. The strength and position of simulated western Pacific subtropical high (WPSH) and its ridge line compare more favourably with observations in SLD and FV than in EUL. They contribute to the intensification of the south-easterly along the south of WPSH and the vertical motion through the troposphere around 30° N, where the subtropical rain belt exists. Additionally, SLD simulates the scope of the westerly jet core over East Asia more realistically than the other two dynamic cores do. Considerable systematic errors of the seasonal migration of monsoon rain belt and water vapour flux exist in all of the three versions of CAM3.1 model, although it captures the broad northward shift of convection, and the simulated results share similarities. The interannual variation of EASM is found to be more accurate in SLD simulation, which reasonably reproduces the leading combined patterns of precipitation and 850-hPa winds in East Asia, as well as the 2.5- and 10-year periods of Li-Zeng EASM index. These results emphasise the importance of dynamic cores for the EASM simulation as distinct from the simulation's sensitivity to the physical parameterisations.

  11. [125th anniversary of the Serbian Medical Society].

    PubMed

    Sulović, V; Pavlović, B

    2002-01-01

    Serbian Medical Society was founded on April 22, 1872. Foundation initiators were physicians of the following nationalities: 5 Serbs, 3 Czechs, 2 Poles, 3 Germans, 1 Slovak and 1 Greek. Josip Pancić was one of its founders as well, and the first president of the Serbian Academy of Sciences and Arts. Dr. Aćim Medović was elected its first President at the Inaugural Assembly, and Dr. Vladan Dordević its Secretary. Later, on October 17, 1874 Constitution of the Serbian Medical Society was passed and its was acknowledged by the Serbian Interior Minister. The first professional meeting was held on August 5, 1872, when they started the first medical journal named "Serbian Archives for All Physicians" ("Srpski arhiv za celokupno lekarstvo") that is being published regularly even today. At the proposal of SLD a Law on Medical Protection was passed (1881). This Law was translated into two European languages, German and French, and sent to be reconsidered by 400 towns throughout Europe. This Law included, beside the other things, the following: "...penny intended for health cannot be spent either by King, or by the Government or by any political party because it is intended for the health, tratement of the sick and doctors' salaries..." The first Congress of the Serbian physicians and scientists devoted to natural sciences was held in Belgrade from 5th to 7th of September, 1904, and it gahtered about 433 participants, among which over hundred were from abroad. In 1907 SLD organized in Belgrade "The First Scientific Conference of Yugoslav Doctors for Operating Surgery". Red Cross in Serbia was founded upon the initiative of SLD. The first initiative to establish the School of Medicine in Belgrade was given by SLD as well. Members of SLD proved their loyalty and devotion to their people, democracy and liberty during liberation wars in XIX and XX century by putting themselves in service of the sich and wrecked. Today, SLD realizes its professional activity through the work of 76 specialized sections, over 100 branches throughout the Republic of Serbia and the Medical Academy of SLD. Specialized sections publish 11 specialized medical journals. We want to emphasize that the Serbian Medical Society has remained, since its foundation, a non-governmental and apolitical organization.

  12. Perceptions of Individual Education Plan Team on Identification of English Language Learners with Specific Learning Disability

    ERIC Educational Resources Information Center

    Adekanye, Emily

    2017-01-01

    Students identified as learners with specific Learning Disabilities (SLD) represent almost half of the total special education population. With the high numbers of students identified as SLD, there has also been the concern of over-identification of immigrant students called English language learners (ELLs), which leads to disproportionality in…

  13. SLD Identification: A Survey of Methods Used by School Psychologists

    ERIC Educational Resources Information Center

    Watson, Michael D., Jr.; Simon, Joan B.; Nunnley, Lenora

    2016-01-01

    IDEA 2004 opened the door for states, and in some cases districts, to choose among three different methods for identifying children with Specific Learning Disabilities (SLDs). This study provides an in-depth look at SLD identification practices in a state that allows school psychologists to use any of the three methods. Eighty-four school…

  14. State Policy and Guidance for Identifying Learning Disabilities in Culturally and Linguistically Diverse Students

    ERIC Educational Resources Information Center

    Scott, Amy N.; Boynton Hauerwas, Laura; Brown, Rachel D.

    2014-01-01

    This study investigates how state Departments of Education address the needs of culturally and linguistically diverse (CLD) students as they relate to the identification of students with a specific learning disability (SLD). A qualitative research design of directed content analysis was used to examine each state's regulatory criteria for SLD, as…

  15. Stress Levels of Kuwaiti Mothers of Children with SLD: Does Work and Educational Status Matter?

    ERIC Educational Resources Information Center

    Alazemi, Saad S.; Hadadian, Azar; Merbler, John B.; Wang, Cen

    2015-01-01

    Existing research literature indicates that parents of children with disabilities have higher stress. The purpose of this study was to examine differences in stress levels between mothers in relation to their children with specific learning disabilities (SLD). A sub sample of 91 mothers participated in the study. The outcome of the research…

  16. Specific Learning Disabilities in DSM-5: Are the Changes for Better or Worse?

    ERIC Educational Resources Information Center

    Tannock, Rosemary

    2013-01-01

    DSM-5, the fifth edition of the American Psychiatric Association's "Diagnostic and Statistical Manual of Mental Disorders," was published in May 2013, amidst a storm of controversy. This article focuses on changes made to the diagnostic criteria for Specific Learning Disorders (SLD). Primary criticisms of the changes in the SLD concern…

  17. Encouraging Free Play: Extramural Digital Game-Based Language Learning as a Complex Adaptive System

    ERIC Educational Resources Information Center

    Scholz, Kyle

    2017-01-01

    Massively multiplayer online role-playing games like World of Warcraft are ideally suited to encourage and facilitate second language development (SLD) in the extramural setting, but to what extent do the language learners' actual trajectories of gameplay contribute to SLD? With the current propensity to focus research in digital game-based…

  18. Teacher Perceptions of Response to Intervention Implementation in Light of IDEA Goals

    ERIC Educational Resources Information Center

    Jenkins, J. Kevin; Sekayi, Dia

    2016-01-01

    Traditionally, school systems have identified students with specific learning disabilities (SLD) by a measured gap between achievement and ability in a specific area. Recent amendments to the IDEA allowed for the use of alternative methods of identifying students with a SLD. Some states have responded by using Response to Intervention (RTI). This…

  19. Response to Intervention for Specific Learning Disabilities Identification: The Impact of Graduate Preparation and Experience on Identification Consistency

    ERIC Educational Resources Information Center

    Maki, Kathrin E.

    2018-01-01

    Response to intervention (RTI) is increasingly being implemented in schools as a means to identify students with specific learning disabilities (SLD). Despite its wide use, there is limited research regarding school psychologists' graduate preparation in and familiarity with RTI for SLD identification. This study examined how school psychologists'…

  20. Dynamics of Shape Memory Alloy Systems, Phase 2

    DTIC Science & Technology

    2015-12-22

    M.A. Savi, S.L.D. Paiva & A.C.P. Brasil Jr., Applied Ecology and Environmental Research, v.11, n.3, pp.463-490, 2013. ISSN 1589-1623. 26...Dynamics and Chaos of the Daisyworld Employed for Global Warming Description", F.M. Viola, M.A. Savi, S.L.D. Paiva & A.C.P. Brasil Jr., Applied Ecology

  1. Self-Advocacy from the Perspective of Young Adults with Specific Learning Disabilities during the Transition Process

    ERIC Educational Resources Information Center

    Schreifels, Julie M.

    2013-01-01

    High school graduates with specific learning disabilities (SLD) often lack sufficient skills to advocate for themselves in adult situations. This limited advocacy ability of young adults with SLD contributes to their higher postsecondary school drop-out rate, lower paying jobs, and a greater dependence on family and public assistance programs for…

  2. Further Assessment of MVD Effects in SLD Applications

    NASA Technical Reports Server (NTRS)

    Tsao, Jen-Ching; Anderson, David N.

    2006-01-01

    The study reported here is part of an effort to develop scaling methods for super cooled large droplet (SLD) conditions. Previously reported results showed that SLD main ice shapes can be simulated quite successfully by appendix C conditions using scaling methods developed for appendix C. However, when the velocity was higher than 100 kt, the feather size and density for SLD tests at MVDs well above 100 m was not well represented by the scaled appendix C conditions. This paper reports additional results of a study of the feather region with the objective of identifying differences between SLD and appendix C feathers. Both the feather appearance and the angle at which feathers grow from the airfoil surface were recorded over a range of MVD from 20 to 190 m for airspeeds of 100 and 200 kt and stagnation freezing fractions of 0.3 to 1.0. Tests were performed in the NASA Glenn Icing Research Tunnel (IRT) using a 91-cm-chord NACA0012 airfoil model mounted at 0 degrees AOA. Photographs are presented to illustrate details of feather appearance. Appearance was noticeably affected by the stagnation freezing fraction of the test, but not by velocity or MVD. The angle of feather growth relative to the chord line decreased with increasing stagnation freezing fraction. For a velocity of 100 kt, no significant effect of MVD on feather angle was apparent, but at 200 kt, feather angle tended to increase with MVD for glaze conditions, but not rime. This finding is based on limited data, and its significance with respect to icing physics has not been determined.

  3. Differences in speech and language abilities between children with 22q11.2 deletion syndrome and children with phenotypic features of 22q11.2 deletion syndrome but without microdeletion.

    PubMed

    Rakonjac, Marijana; Cuturilo, Goran; Stevanovic, Milena; Jelicic, Ljiljana; Subotic, Misko; Jovanovic, Ida; Drakulic, Danijela

    2016-08-01

    22q11.2DS is the most common microdeletion syndrome in humans, usually associated with speech and language delay (SLD). Approximately 75% of children with 22q11.2 microdeletion have congenital heart malformations (CHM) which after infant open-heart surgery might lead to SLD. The purpose of this study was to determine whether factors associated with microdeletion contribute to SLD in children with 22q11.2DS. We compared speech and language abilities of two groups of school-aged children: those with 22q11.2 microdeletion (E1) and those with the phenotype resembling 22q11.2DS but without the microdeletion (E2). An age-matched group of typically developing children was also tested. The obtained results revealed that children from group E1 have lower level of speech and language abilities compared to children from group E2 and control group. Additionally, mild to moderate SLD was detected in children from group E2 compared to children from the control group. The obtained results imply that both CHM after infant open-heart surgery and other factors associated with 22q11.2 microdeletion, contribute to SLD in patients with 22q11.2 microdeletion. Based on this, we could postulate that there is/are some potential candidate gene(s), located in the 22q11.2 region, whose function could be important for speech and language development. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Incidence and Functional Outcomes of Scapholunate Diastases Associated Distal Radius Fractures: A 2-year Follow-Up Scapholunate Dissociation.

    PubMed

    Lans, Jonathan; Lasa, Alejandro; Chen, Neal C; Jupiter, Jesse B

    2018-01-01

    The Scapholunate Interosseous Ligament (SLIL) is the first intrinsic carpal ligament to be injured in wrist trauma, present in up to 64% of the distal radius fractures. However, it remains unclear what patients develop symptoms, making primary treatment of these injuries accompanying distal radius fractures remains questionable. The aim of this study was to evaluate the functional outcomes of patients with scapholunate diastasis associated with distal radius fractures. We evaluated 391 patients with a distal radius fracture. Using Computer Tomography (CT) scans the scapholunate interval was measured. We identified 14 patients with an SLD (>3mm) of the injured wrist, which underwent a CT-scan of the contralateral wrist. To evaluate the functional outcomes at a mean follow up of 136±90 weeks, we used the Quick Disabilities of the Arm, Shoulder and Hand (qDASH) Score. There were 8 patients with bilateral SLD and 6 patients with unilateral SLD. Five patients had a qDASH score of 0 and one patient showed a qDASH score of 18.2. The patient with a poor score had bilateral preexisting osteoarthritis of the wrist. No patient had additional surgery of the SLIL. In patients with distal radius fractures, more than half of the 14 patients with an SL gap on CT had widening on the contralateral side. It is therefore worthwhile to image the contralateral wrist before diagnosing a SLD. The patients with unilateral SLD should not be surgically treated at initial presentation because they may have good functional outcomes after a follow up of 2 years.

  5. The Experiences of Parents with Adolescents Identified as Having a Specific Learning Disability

    ERIC Educational Resources Information Center

    Seals, Linda J.

    2010-01-01

    Of the 6.6 million children in the United States who were deemed in 2008 to have a disability that required special instruction, over 39% were classified as specific learning disabled (SLD). This figure translates into a high number of people who are parenting a child identified as having a SLD. Bronfenbrenner's theory of the ecology of human…

  6. Emotional and Meta-Emotional Intelligence as Predictors of Adjustment Problems in Students with Specific Learning Disorders

    ERIC Educational Resources Information Center

    D'Amico, Antonella; Guastaferro, Teresa

    2017-01-01

    The purpose of this study was to analyse adjustment problems in a group of adolescents with a Specific Learning Disorder (SLD), examining to what extent they depend on the severity level of the learning disorder and/or on the individual's level of emotional intelligence. Adjustment problems,, perceived severity levels of SLD, and emotional and…

  7. STS-55 German Payload Specialist Walter freefloats inside the SL-D2 module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter demonstrates the microgravity aboard the Spacelab Deutsche 2 (SL-D2) science module in Columbia's, Orbiter Vehicle (OV) 102's, payload bay (PLB). The module served as his space laboratory and that of his six crewmates for 10 days. Walter represents the German Aerospace Research Establishment (DLR).

  8. Characterization of two familial cases presenting with a syndromic specific learning disorder and carrying (17q;21q) unbalanced translocations.

    PubMed

    Coton, Julie; Labalme, Audrey; Till, Marianne; Bussy, Gerald; Krifi Papoz, Sonia; Lesca, Gaetan; Heron, Delphine; Sanlaville, Damien; Edery, Patrick; des Portes, Vincent; Rossi, Massimiliano

    2018-05-01

    Chromosomal microarray (CMA) can detect pathogenic copy number variations in 15-20% of individuals with intellectual disability and in 10% of patients with autism spectrum disorders. The diagnostic rate in specific learning disorders (SLD) is unknown. Our study emphasizes the usefulness of CMA in the diagnostic workout assessment of familial SLD.

  9. Achievement Error Differences of Students with Reading versus Math Disorders

    ERIC Educational Resources Information Center

    Avitia, Maria; DeBiase, Emily; Pagirsky, Matthew; Root, Melissa M.; Howell, Meiko; Pan, Xingyu; Knupp, Tawnya; Liu, Xiaochen

    2017-01-01

    The purpose of this study was to understand and compare the types of errors students with a specific learning disability in reading and/or writing (SLD-R/W) and those with a specific learning disability in math (SLD-M) made in the areas of reading, writing, language, and mathematics. Clinical samples were selected from the norming population of…

  10. Vineland-II adaptive behavior profile of children with attention-deficit/hyperactivity disorder or specific learning disorders.

    PubMed

    Balboni, Giulia; Incognito, Oriana; Belacchi, Carmen; Bonichini, Sabrina; Cubelli, Roberto

    2017-02-01

    The evaluation of adaptive behavior is informative in children with attention-deficit/hyperactivity disorder (ADHD) or specific learning disorders (SLD). However, the few investigations available have focused only on the gross level of domains of adaptive behavior. To investigate which item subsets of the Vineland-II can discriminate children with ADHD or SLD from peers with typical development. Student's t-tests, ROC analysis, logistic regression, and linear discriminant function analysis were used to compare 24 children with ADHD, 61 elementary students with SLD, and controls matched on age, sex, school level attended, and both parents' education level. Several item subsets that address not only ADHD core symptoms, but also understanding in social context and development of interpersonal relationships, allowed discrimination of children with ADHD from controls. The combination of four item subsets (Listening and attending, Expressing complex ideas, Social communication, and Following instructions) classified children with ADHD with both sensitivity and specificity of 87.5%. Only Reading skills, Writing skills, and Time and dates discriminated children with SLD from controls. Evaluation of Vineland-II scores at the level of item content categories is a useful procedure for an efficient clinical description. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Airframe Icing Research Gaps: NASA Perspective

    NASA Technical Reports Server (NTRS)

    Potapczuk, Mark

    2009-01-01

    qCurrent Airframe Icing Technology Gaps: Development of a full 3D ice accretion simulation model. Development of an improved simulation model for SLD conditions. CFD modeling of stall behavior for ice-contaminated wings/tails. Computational methods for simulation of stability and control parameters. Analysis of thermal ice protection system performance. Quantification of 3D ice shape geometric characteristics Development of accurate ground-based simulation of SLD conditions. Development of scaling methods for SLD conditions. Development of advanced diagnostic techniques for assessment of tunnel cloud conditions. Identification of critical ice shapes for aerodynamic performance degradation. Aerodynamic scaling issues associated with testing scale model ice shape geometries. Development of altitude scaling methods for thermal ice protections systems. Development of accurate parameter identification methods. Measurement of stability and control parameters for an ice-contaminated swept wing aircraft. Creation of control law modifications to prevent loss of control during icing encounters. 3D ice shape geometries. Collection efficiency data for ice shape geometries. SLD ice shape data, in-flight and ground-based, for simulation verification. Aerodynamic performance data for 3D geometries and various icing conditions. Stability and control parameter data for iced aircraft configurations. Thermal ice protection system data for simulation validation.

  12. Effect of drop size on the impact thermodynamics for supercooled large droplet in aircraft icing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Chen; Liu, Hong, E-mail: hongliu@sjtu.edu.cn

    Supercooled large droplet (SLD), which can cause abnormal icing, is a well-known issue in aerospace engineering. Although efforts have been exerted to understand large droplet impact dynamics and the supercooled feature in the film/substrate interface, respectively, the thermodynamic effect during the SLD impact process has not received sufficient attention. This work conducts experimental studies to determine the effects of drop size on the thermodynamics for supercooled large droplet impingement. Through phenomenological reproduction, the rapid-freezing characteristics are observed in diameters of 400, 800, and 1300 μm. The experimental analysis provides information on the maximum spreading rate and the shrinkage rate ofmore » the drop, the supercooled diffusive rate, and the freezing time. A physical explanation of this unsteady heat transfer process is proposed theoretically, which indicates that the drop size is a critical factor influencing the supercooled heat exchange and effective heat transfer duration between the film/substrate interface. On the basis of the present experimental data and theoretical analysis, an impinging heating model is developed and applied to typical SLD cases. The model behaves as anticipated, which underlines the wide applicability to SLD icing problems in related fields.« less

  13. STS-55 German Payload Specialist Schlegel manipulates ROTEX controls in SL-D2

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 2 Hans Schlegel, wearing goggles (eye glasses) and positioned in front of Spacelab Deutsche 2 (SL-D2) Rack 4 System Rack controls, operates Robotics Technology Experiment (ROTEX) arm. ROTEX is a robotic arm that operates within an enclosed workcell in Rack 6 (partially visible in the foreground) and uses teleoperation from both an onboard station located nearby in Rack 4 and from a station on the ground. The device uses teleprogramming and artificial intelligence to look at the design, verification and operation of advanced autonomous systems for use in future applications. Schlegel represents the German Aerospace Research Establishment (DLR). SL-D2, a German-managed payload, is aboard Columbia, Orbiter Vehicle (OV) 102, for this science research mission.

  14. Students with Specific Learning Disabilities Can Pass State Competency Exams: Systematic Strategy Instruction Makes a Difference

    ERIC Educational Resources Information Center

    Barry, Leasha M.; Moore, William E., IV

    2004-01-01

    Students with specific learning disabilities (SLD) are required to pass the same competency exams as students enrolled in general education in order to graduate to new grade levels and to earn a high school diploma. In this study, the authors taught students with SLD a self-directed organizational strategy designed to assist them in passing the…

  15. Polarization insensitive and low-loss coupling mode-size converter from super luminescent diode to silica-based planar lightwave circuit

    NASA Astrophysics Data System (ADS)

    She, Xuan; Li, Bei; Chen, Kan; Li, Ke; Shu, Xiaowu; Liu, Cheng

    2017-02-01

    We present a design of a laterally tapered optical waveguide mode-size converter from super luminescent diode (SLD) to silica-based planar lightwave circuit (PLC). The mode-size converter is based on silica-based PLC. By using three dimensional semi-vectorial beam propagation methods, laterally tapered waveguides with different boundaries are simulated and compared with each other, where the factors of polarization-dependent loss and coupling loss are mainly focused on. The results show that the most influential factor for polarization-dependent loss is the ratio of the divergence angle of SLD in the horizontal direction and the vertical direction. The refractive index difference Δ between core layer and cladding layer, core width of endface and taper length influence coupling loss mostly, while the effect of all side boundaries is within 0.05 dB. We also investigate the SLD misalignment tolerance and wavelength bandwidth's impact on coupling loss. Furthermore, we examine the performance of the mode-size converter based on a particular SLD which has a divergence angle of 30°×45°. By optimizing the parameters of the tapered waveguide, the coupling efficiency is increased to 62.4% and the polarization-dependent loss is reduced to 0.035 dB. Meanwhile, it eΔnables us to reduce the coupling loss variation to 0.05dB with core width of endface fabrication tolerance of ±0.5 μm and taper length tolerance of ±0.5 mm. The proposed mode-size converter has been demonstrated to be well performed, implying its application in the optical transceiver module using SLD as light source and hybrid integration of III-V semiconductor waveguiding devices and PLCs.

  16. Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial.

    PubMed

    Chen, Ingrid; Diawara, Halimatou; Mahamar, Almahamoudou; Sanogo, Koualy; Keita, Sekouba; Kone, Daouda; Diarra, Kalifa; Djimde, Moussa; Keita, Mohamed; Brown, Joelle; Roh, Michelle E; Hwang, Jimee; Pett, Helmi; Murphy, Maxwell; Niemi, Mikko; Greenhouse, Bryan; Bousema, Teun; Gosling, Roly; Dicko, Alassane

    2018-03-28

    The World Health Organization recommendation on the use of a single low dose of primaquine (SLD-PQ) to reduce Plasmodium falciparum malaria transmission requires more safety data. We conducted an open-label, nonrandomized, dose-adjustment trial of the safety of 3 single doses of primaquine in glucose-6-phosphate dehydrogenase (G6PD)-deficient adult males in Mali, followed by an assessment of safety in G6PD-deficient boys aged 11-17 years and those aged 5-10 years, including G6PD-normal control groups. The primary outcome was the greatest within-person percentage drop in hemoglobin concentration within 10 days after treatment. Fifty-one participants were included in analysis. G6PD-deficient adult males received 0.40, 0.45, or 0.50 mg/kg of SLD-PQ. G6PD-deficient boys received 0.40 mg/kg of SLD-PQ. There was no evidence of symptomatic hemolysis, and adverse events considered related to study drug (n = 4) were mild. The mean largest within-person percentage change in hemoglobin level between days 0 and 10 was -9.7% (95% confidence interval [CI], -13.5% to -5.90%) in G6PD-deficient adults receiving 0.50 mg/kg of SLD-PQ, -11.5% (95% CI, -16.1% to -6.96%) in G6PD-deficient boys aged 11-17 years, and -9.61% (95% CI, -7.59% to -13.9%) in G6PD-deficient boys aged 5-10 years. The lowest hemoglobin concentration at any point during the study was 92 g/L. SLD-PQ doses between 0.40 and 0.50 mg/kg were well tolerated in G6PD-deficient males in Mali. NCT02535767.

  17. An analysis of science conceptual knowledge in journals of students with disabilities and normally achieving students

    NASA Astrophysics Data System (ADS)

    Grigg, Gail S.

    Science education reforms of the last two decades have focused on raising the bar for ALL students which includes students with mild to moderate disabilities. Formative assessment can be used to assess the progress of these students to inquire, understand scientific concepts, reason scientifically, make decisions, and communicate effectively in science. The purpose of this study is to examine the use of science journals as a formative assessment in a guided inquiry unit of study for students with learning disabilities. Two normally achieving students (NA) and five students with learning disabilities (SLD) participated in a study of mammals that utilized journals to record the development of student knowledge through the course of study. Students were interviewed after the lessons were complete using the same prompts required in the journals. Themes were developed from the student writings and their verbal discourse using Grounded Theory. Journals and verbal discourse were rated following the themes of Knowledge Telling (KT) and Knowledge Transformation (KTR). Concept maps were developed for the Pre and Post test lessons (written and verbal discourses) by the raters in an attempt to further explain the knowledge that the students conveyed. The results of this study suggest that SLD are able to demonstrate knowledge about mammals better through verbal discourse than written discourse. While the NA students wrote more and used more technical discourse than did their SLD peers, the conceptual understanding of the topic by the SLD was no less inclusive than their NA peers when accessed verbally. The journals demonstrated limited conceptual growth for the SLD. Further, while lexical density is important to the development of knowledge in science, this study suggests the "conceptual density" may be another important indicator to examine.

  18. Influence of stuttering variation on talker group classification in preschool children: Preliminary findings

    PubMed Central

    Johnson, Kia N.; Karrass, Jan; Conture, Edward G.; Walden, Tedra

    2010-01-01

    The purpose of this study was to investigate whether variations in disfluencies of young children who do (CWS) and do not stutter (CWNS) significantly change their talker group classification or diagnosis from stutterer to nonstutterer, and vice versa. Participants consisted of 17 3- to 5-year-old CWS and 9 3- to 5-year-old CWNS, with no statistically significant between-group difference in chronological age (CWS: M = 45.53 months, SD = 8.32; CWNS: M = 47.67 months, SD = 6.69). All participants had speech, language, and hearing development within normal limits, with the exception of stuttering for CWS. Both talker groups participated in a series of speaking samples that varied by: (a) conversational partner [parent and clinician], (b) location [home and clinic], and (c) context [conversation and narrative]. The primary dependent measures for this study were the number of stuttering-like disfluencies (SLD) per total number of spoken words [%SLD] and the ratio of SLD to total disfluencies (TD) [SLD/TD]. Results indicated that significant variability of stuttering did not exist as a result of conversational partner or location. Changes in context, however, did impact the CWS, who demonstrated higher SLD/TD in the conversation sample versus a narrative sample. Consistent with hypotheses, CWS and CWNS were accurately identified as stutterers and nonstutterers, respectively, regardless of changes to conversational partner, location or context for the overall participant sample. Present findings were taken to suggest that during assessment, variations in stuttering frequency resulting from changes in conversational partner, location or context do not significantly influence the diagnosis of stuttering, especially for children not on the talker group classification borderline between CWS and CWNS. PMID:19167719

  19. Incidence and Functional Outcomes of Scapholunate Diastases Associated Distal Radius Fractures: A 2-year Follow-Up Scapholunate Dissociation

    PubMed Central

    Lans, Jonathan; Lasa, Alejandro; Chen, Neal C.; Jupiter, Jesse B.

    2018-01-01

    Background: The Scapholunate Interosseous Ligament (SLIL) is the first intrinsic carpal ligament to be injured in wrist trauma, present in up to 64% of the distal radius fractures. However, it remains unclear what patients develop symptoms, making primary treatment of these injuries accompanying distal radius fractures remains questionable. Objective: The aim of this study was to evaluate the functional outcomes of patients with scapholunate diastasis associated with distal radius fractures. Methods: We evaluated 391 patients with a distal radius fracture. Using Computer Tomography (CT) scans the scapholunate interval was measured. We identified 14 patients with an SLD (>3mm) of the injured wrist, which underwent a CT-scan of the contralateral wrist. To evaluate the functional outcomes at a mean follow up of 136±90 weeks, we used the Quick Disabilities of the Arm, Shoulder and Hand (qDASH) Score. Results: There were 8 patients with bilateral SLD and 6 patients with unilateral SLD. Five patients had a qDASH score of 0 and one patient showed a qDASH score of 18.2. The patient with a poor score had bilateral preexisting osteoarthritis of the wrist. No patient had additional surgery of the SLIL. Conclusion: In patients with distal radius fractures, more than half of the 14 patients with an SL gap on CT had widening on the contralateral side. It is therefore worthwhile to image the contralateral wrist before diagnosing a SLD. The patients with unilateral SLD should not be surgically treated at initial presentation because they may have good functional outcomes after a follow up of 2 years. PMID:29456778

  20. The SLD VXD3 detector and its initial performance

    NASA Astrophysics Data System (ADS)

    Abe, K.; Arodzero, A.; Baltay, C.; Brau, J.; Breidenbach, M.; Burrows, P. N.; Chou, A.; Crawford, G.; Damerell, C.; Dervan, P.; Dong, D.; Emmet, W.; English, R.; Etzion, E.; Foss, M.; Frey, R.; Haller, G.; Hasuko, K.; Hertzbach, S.; Hoeflich, J.; Huber, J.; Huffer, M.; Jackson, D.; Jaros, J.; Kelsy, J.; Kendall, H.; Lee, I.; Lia, V.; Lintern, L.; Liu, M.; Manly, S.; Masuda, H.; Moore, T.; Nagamine, T.; Ohishi, N.; Osborne, L.; Ross, D.; Russell, J.; Serbo, V.; Sinev, N.; Sinnott, J.; Skarpaas, K. Viii; Smy, M.; Snyder, J.; Strauss, M.; Dong, S.; Suekane, F.; Taylor, F.; Trandafir, A.; Usher, T.; Verdier, R.; Watts, S.; Weiss, E.; Yashima, J.; Yuta, H.; Zapalac, G.

    1997-02-01

    The SLD collaboration completed construction of a new CCD vertex detector (VXD3) in January 1996 and started data taking in April 1996 with the new system. VXD3 is an upgrade of the original CCD vertex detector, VXD2, which had successfully operated in SLD for three years. VXD3 consists of 96 large area CCDs, each having 3.2 million 20 μm × 20 μm pixels. By reducing the detector material and lengthening the lever arm, VXD3 is expected to improve secondary vertex resolution by about a factor of two compared with VXD2. The new three-layered structure enables stand-alone tracking without any ambiguity and its extended size along the beam direction improves the polar-angle coverage to |cos θ| < 0.85. An overview of this detector system and its initial performance are described.

  1. Second Line of Defense Spares Program Assessment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Henderson, Dale L.; Muller, George; Mercier, Theresa M.

    2012-11-20

    The Office of the Second Line of Defense (SLD) is part of the Department of Energy‘s (DOE) National Nuclear Security Administration (NNSA). The SLD Program accomplishes its critical global security mission by forming cooperative relationships with partner countries to install passive radiation detection systems that augment traditional inspection and law enforcement measures by alerting border officials to the presence of special nuclear or other radiological materials in cross-border traffic. An important tenet of the program is to work collaboratively with these countries to establish the necessary processes, procedures, infrastructure and conditions that will enable them to fully assume the financialmore » and technical responsibilities for operating the equipment. As the number of operational deployments grows, the SLD Program faces an increasingly complex logistics process to promote the timely and efficient supply of spare parts.« less

  2. STS-55 German Payload Specialist Schlegel works at SL-D2 Biolabor microscope

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 2 Hans Schlegel loads sample into a microscope at the Spacelab Deutsche 2 (SL-D2) Rack 7 Biolabor (BB) workstation. The BB facility is a life sciences and biotechnology research device developed by Germany (MBB/ERNO) for use aboard Spacelab. Schlegel represents the German Aerospace Research Establishment (DLR) during this 10-day mission aboard Columbia, Orbiter Vehicle (OV) 102.

  3. STS-55 Payload Specialist Schlegel collects fungi sample at SL-D2 Rack 1

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 2 Hans Schlegel, wearing lightweight headset, collects fungi sample while working at Spacelab Deutsche 2 (SL-D2) science module Rack 1 Work Bench. Schlegel is conducting these procedures in conjunction with the 'Fruiting Body Development of Fungi' experiment. Schlegel was one of two payload specialists representing the German Aerospace Research Establishment (DLR) on the 10-day spacelab mission.

  4. Ice Roughness in Short Duration SLD Icing Events

    NASA Technical Reports Server (NTRS)

    McClain, Stephen T.; Reed, Dana; Vargas, Mario; Kreeger, Richard E.; Tsao, Jen-Ching

    2014-01-01

    Ice accretion codes depend on models of roughness parameters to account for the enhanced heat transfer during the ice accretion process. While mitigating supercooled large droplet (SLD or Appendix O) icing is a significant concern for manufacturers seeking future vehicle certification due to the pending regulation, historical ice roughness studies have been performed using Appendix C icing clouds which exhibit mean volumetric diameters (MVD) much smaller than SLD clouds. Further, the historical studies of roughness focused on extracting parametric representations of ice roughness using multiple images of roughness elements. In this study, the ice roughness developed on a 21-in. NACA 0012 at 0deg angle of attack exposed to short duration SLD icing events was measured in the Icing Research Tunnel at the NASA Glenn Research Center. The MVD's used in the study ranged from 100 micrometer to 200 micrometers, in a 67 m/s flow, with liquid water contents of either 0.6 gm/cubic meters or 0.75 gm/cubic meters. The ice surfaces were measured using a Romer Absolute Arm laser scanning system. The roughness associated with each surface point cloud was measured using the two-dimensional self-organizing map approach developed by McClain and Kreeger (2013) resulting in statistical descriptions of the ice roughness.

  5. Delay of behavioral estrus in hamsters and phenobarbital.

    PubMed

    Alleva, J J

    1989-01-01

    The onset of behavioral estrus was used as a phase marker of the hamster timing system in SLD 16:8 (dark 20:00-04:00). TZ was injected between 11:00 of cycle day 3 and noon of cycle day 4 when onset of estrus was determined. At no time did injection of TZ cause a phase advance in SLD 16:8. Small delays of estrus resulted from 11:00-16:00 injections but marked delays began with the 17:00 injection. Phenobarbital was injected between noon and 19:30 on cycle day 3. Injections between noon and 16:00 had no effect but all later injections beginning at 17:00 delayed estrus, the 17:30 injection causing the greatest delay. Diazepam also markedly delayed estrus when tested at 17:30. These results with three drugs support results with light pulses that 18:00 in SLD 16:8 marks the same phase of the 24-h hamster timing system as the onset of wheel running does in DD, LL, and WLD. These findings with three GABA potentiators extend to SLD previous evidence based on the onset of wheel running in DD, LL and WLD that GABA may be involved in hamster timekeeping and its responses to light and drugs.

  6. Nonverbal imitation skills in children with specific language delay.

    PubMed

    Dohmen, Andrea; Chiat, Shula; Roy, Penny

    2013-10-01

    Research in children with language problems has focussed on verbal deficits, and we have less understanding of children's deficits with nonverbal sociocognitive skills which have been proposed to be important for language acquisition. This study was designed to investigate elicited nonverbal imitation in children with specific language delay (SLD). It is argued that difficulties in nonverbal imitation, which do not involve the processing of structural aspects of language, may be indicative of sociocognitive deficits. Participants were German-speaking typically developing children (n=60) and children with SLD (n=45) aged 2-3 ½ years. A novel battery of tasks measured their ability to imitate a range of nonverbal target acts that to a greater or lesser extent involve sociocognitive skills (body movements, instrumental acts on objects, pretend acts). Significant group differences were found for all body movement and pretend act tasks, but not for the instrumental act tasks. The poorer imitative performance of the SLD sample was not explained by motor or nonverbal cognitive skills. Thus, it appeared that the nature of the task affected children's imitation performance. It is argued that the ability to establish a sense of connectedness with the demonstrator was at the core of children's imitation difficulty in the SLD sample. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. STS-55 Payload Specialist Schlegel collects fungi sample at SL-D2 Rack 1

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 2 Hans Schlegel, wearing lightweight headset, collects fungi sample while working at Spacelab Deutsche 2 (SL-D2) science module Rack 1 Work Bench. Schlegel is conducting these procedures in conjunction with the 'Fruiting Body Development of Fungi' experiment. Pieces of the experiment casing freefloat in the workstation.Schlegel represents the German Aerospace Research Establishment (DLR) on the 10-day spacelab mission.

  8. Evaluating the Sonic Layer Depth Relative to the Mixed Layer Depth

    DTIC Science & Technology

    2008-07-24

    upper ocean to trap acoustic energy in a surface duct while MLD characterizes upper ocean mixing. The SLD is computed from temperature and salinity...and compared over the annual cycle. The SLD characterizes the potential of the upper ocean to trap acoustic energy in a surface duct while MLD...exists a tropical cyclone formation [e.g., Mao et al., 2000], to Minimum acoustic Cutoff Frequency (MCF) above which phytoplankton bloom critical depth

  9. STS-55 German Payload Specialist Walter at the SL-D2 Fluid Physics Module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter conducts an experiment using the advanced fluid physics module located in Spacelab Deutsche 2 (SL-D2) Rack 8 Werkstofflabor (WL) (Material Sciences Laboratory) aboard Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Walter uses intravehicular activity (IVA) foot restraints to position himself in front of the rack. Walter represents the German Aerospace Research Establishment (DLR) on the 10-day mission.

  10. Low-Cost WDM-PON With Colorless Bidirectional Transceivers

    NASA Astrophysics Data System (ADS)

    Shin, Dong Jae; Keh, Y. C.; Kwon, J. W.; Lee, E. H.; Lee, J. K.; Park, M. K.; Park, J. W.; Oh, Y. K.; Kim, S. W.; Yun, I. K.; Shin, H. C.; Heo, D.; Lee, J. S.; Shin, H. S.; Kim, H. S.; Park, S. B.; Jung, D. K.; Hwang, Seongtaek; Oh, Y. J.; Jang, D. H.; Shim, C. S.

    2006-01-01

    This paper presents a low-cost bidirectional (BiDi) wavelength-division-multiplexed passive optical network (WDM-PON) employing colorless uncooled BiDi transceivers (TRxs) and superluminescent diode (SLD)-based broadband light sources (BLSs). The C band is allocated for upstream and the E+ band for downstream in consideration of BiDi packaging, SLD development, and wavelength alignment of dual-window arrayed waveguide gratings (AWGs). The BiDi TRx integrates an uncooled Fabry-Pérot laser diode (FP-LD), a p-i-n photodiode (PD), and a 45°-angled thin-film filter in a small-form-factor (SFF) package. The SLD-based BLSs provide 13-dBm amplified spontaneous emissions (ASEs) with spectral ripples of < 3 dB and polarization dependencies of < 1 dB. Colorless operations over 32 100-GHz-spaced channels are demonstrated from -20 to 80°C in 155-Mb/s BiDi transmissions over 25 km.

  11. Differences of Articulation Rate and Utterance Length in Fluent and Disfluent Utterances of Preschool Children Who Stutter

    PubMed Central

    Chon, HeeCheong; Sawyer, Jean; Ambrose, Nicoline G.

    2014-01-01

    Purpose The purpose of this study was to investigate characteristics of four types of utterances in preschool children who stutter: perceptually fluent, containing normal disfluencies (OD utterance), containing stuttering-like disfluencies (SLD utterance), and containing both normal and stuttering-like disfluencies (SLD+OD utterance). Articulation rate and length of utterance were measured to seek the differences. Because articulation rate may reflect temporal aspects of speech motor control, it was predicted that the articulation rate would be different between perceptually fluent utterances and utterances containing disfluencies. The length of utterance was also expected to show different patterns. Method Participants were 14 preschool children who stutter. Disfluencies were identified from their spontaneous speech samples, and articulation rate in syllables per second and utterance length in syllables were measured for the four types of utterances. Results and discussion There was no significant difference in articulation rate between each type of utterance. Significantly longer utterances were found only in SLD+OD utterances compared to fluent utterances, suggesting that utterance length may be related to efforts in executing motor as well as linguistic planning. The SLD utterance revealed a significant negative correlation in that longer utterances tended to be slower in articulation rates. Longer utterances may place more demand on speech motor control due to more linguistic and/or grammatical features, resulting in stuttering-like disfluencies and a decreased rate. PMID:22995336

  12. The effectiveness of a clinical and home-based physical activity program and simple lymphatic drainage in the prevention of breast cancer-related lymphedema: A prospective randomized controlled study.

    PubMed

    Dönmez, Ayşe Arıkan; Kapucu, Sevgisun

    2017-12-01

    To investigate the effectiveness of a clinical and home-based, nurse-led physical activity program (PAP) and simple lymphatic drainage (SLD) in the prevention of breast cancer-related lymphedema. A total of 52 breast cancer patients were randomized to either a PAP and SLD program (n = 25) or a control group (n = 27). Patients in both groups were also provided training for lymphedema. The PAP and SLD were administered through home visits by the investigators, twice a week for six weeks, in the intervention group. The control group did not undergo intervention. The circumference of the upper extremity, symptom severity, and physical function were measured in both groups. The upper extremity circumference increased by about two times from the baseline, in the control group, especially in the sixth week (p < 0.05). Lymphedema-related symptom severity scores were found to decrease significantly in the intervention group, compared to those at the baseline (p < 0.05). It was recommended that PAP and SLD, with a follow-up program, be used for patients who planned to undergo breast cancer surgery, starting from before surgery and continuing until after, to prevent breast cancer-related lymphedema. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Severe liver disease related to chronic hepatitis C virus infection in treatment-naive patients: epidemiological characteristics and associated factors at first expert centre visit, France, 2000 to 2007 and 2010 to 2014

    PubMed Central

    Sanna, Alice; Le Strat, Yann; Roudot-Thoraval, Françoise; Deuffic Burban, Sylvie; Carrieri, Patrizia; Delarocque-Astagneau, Elisabeth; Larsen, Christine

    2017-01-01

    Given recent profound improvements in the effectiveness of antiviral treatment for chronic Hepatitis C virus (HCV) infection, we aimed to describe the characteristics of patients referred to hepatology expert centres in France from 2000 to 2007 and from 2010 to 2014, and to identify factors associated with severe liver disease at their first visit for evaluation. We analysed data from two sources covering all of France: the former hepatitis C surveillance network, which included patients between 2000 and 2007, and the ANRS CO22 HEPATHER multi-centre cohort, which included patients between 2012 and 2014. Severe liver disease (SLD) was defined as the presence of either cirrhosis (histological, biochemical or clinical) or hepatocellular carcinoma. Multivariable Poisson regression models were used to identify the factors associated with SLD in complete-case analysis and after multiple imputation. Overall, 16,851 patients were included in the analysis and SLD was diagnosed in 11.6%. SLD at first visit was significantly associated with known risk factors (male sex, history of excessive alcohol intake, HCV genotype 3), late referral to hepatologists after diagnosis and HCV diagnosis at an older age. Providing earlier specialised care and treatment may be an important target for public health action. PMID:28797326

  14. Super-Resolution Person Re-Identification With Semi-Coupled Low-Rank Discriminant Dictionary Learning.

    PubMed

    Jing, Xiao-Yuan; Zhu, Xiaoke; Wu, Fei; Hu, Ruimin; You, Xinge; Wang, Yunhong; Feng, Hui; Yang, Jing-Yu

    2017-03-01

    Person re-identification has been widely studied due to its importance in surveillance and forensics applications. In practice, gallery images are high resolution (HR), while probe images are usually low resolution (LR) in the identification scenarios with large variation of illumination, weather, or quality of cameras. Person re-identification in this kind of scenarios, which we call super-resolution (SR) person re-identification, has not been well studied. In this paper, we propose a semi-coupled low-rank discriminant dictionary learning (SLD 2 L) approach for SR person re-identification task. With the HR and LR dictionary pair and mapping matrices learned from the features of HR and LR training images, SLD 2 L can convert the features of the LR probe images into HR features. To ensure that the converted features have favorable discriminative capability and the learned dictionaries can well characterize intrinsic feature spaces of the HR and LR images, we design a discriminant term and a low-rank regularization term for SLD 2 L. Moreover, considering that low resolution results in different degrees of loss for different types of visual appearance features, we propose a multi-view SLD 2 L (MVSLD 2 L) approach, which can learn the type-specific dictionary pair and mappings for each type of feature. Experimental results on multiple publicly available data sets demonstrate the effectiveness of our proposed approaches for the SR person re-identification task.

  15. Refractory Anemia with Ring Sideroblasts (RARS) and RARS with Thrombocytosis (RARS-T) – “2017 Update on Diagnosis, Risk-stratification, and Management”

    PubMed Central

    Patnaik, Mrinal M.; Tefferi, Ayalew

    2017-01-01

    Disease Overview Ring sideroblasts (RS) are erythroid precursors with abnormal perinuclear mitochondrial iron accumulation. Two myeloid neoplasms defined by the presence of RS, include refractory anemia with ring sideroblasts (RARS), now classified under myelodysplastic syndromes with RS (MDS-RS) and RARS with thrombocytosis (RARS-T); now called myelodysplastic/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T). Diagnosis MDS-RS is a lower risk MDS, with single or multilineage dysplasia (SLD/MLD), <5% bone marrow (BM) blasts and ≥15% BM RS (≥5% in the presence of SF3B1 mutations). MDS/MPN-RS-T, now a formal entity in the MDS/MPN overlap syndromes, has diagnostic features of MDS-RS-SLD, along with a platelet count ≥ 450 × 10(9)/L and large atypical megakaryocytes (similar to BCR-ABL1 negative MPN). Mutations and Karyotype Mutations in SF3B1 are seen in ≥80% of patients with MDS-RS-SLD and MDS/MPN-RS-T, and strongly correlate with the presence of BM RS; MDS/MPN-RS-T patients also demonstrate JAK2V617F, ASXL1, DNMT3A, SETBP1, and TET2 mutations; with ASXL1/SETBP1 mutations adversely impacting survival. Cytogenetic abnormalities are uncommon in both diseases. Risk stratification Most patients with MDS-RS-SLD are stratified into lower risk groups by the revised-International Prognostic Scoring System (R-IPSS). Disease outcome in MDS/MPN-RS-T is better than that of MDS-RS-SLD, but worse than that of essential thrombocythemia. Both diseases have a low risk of leukemic transformation. Treatment Anemia and iron overload are complications seen in both and are managed similar to lower risk MDS and MPN. Aspirin therapy is reasonable in MDS/MPN-RS-T, especially in the presence of JAK2V617F, but the value of platelet-lowering drugs is uncertain. PMID:28188970

  16. Comparison of image quality, myocardial perfusion, and LV function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: the MILLISIEVERT study

    PubMed Central

    Einstein, Andrew J.; Blankstein, Ron; Andrews, Howard; Fish, Mathews; Padgett, Richard; Hayes, Sean W.; Friedman, John D.; Qureshi, Mehreen; Rakotoarivelo, Harivony; Slomka, Piotr; Nakazato, Ryo; Bokhari, Sabahat; Di Carli, Marcello; Berman, Daniel S.

    2015-01-01

    SPECT myocardial perfusion imaging (MPI) plays a central role in coronary artery disease diagnosis; but concerns exist regarding its radiation burden. Compared to standard Anger-SPECT (A-SPECT) cameras, new high-efficiency (HE) cameras with specialized collimators and solid-state cadmium-zinc-telluride detectors offer potential to maintain image quality (IQ), while reducing administered activity and thus radiation dose to patients. No previous study has compared IQ, interpretation, total perfusion deficit (TPD), or ejection fraction (EF) in patients receiving both ultra-low-dose (ULD) imaging on a HE-SPECT camera and standard low-dose (SLD) A-SPECT imaging. Methods We compared ULD-HE-SPECT to SLD-A-SPECT imaging by dividing the rest dose in 101 patients at 3 sites scheduled to undergo clinical A-SPECT MPI using a same day rest/stress Tc-99m protocol. Patients received HE-SPECT imaging following an initial ~130 MBq (3.5mCi) dose, and SLD-A-SPECT imaging following the remainder of the planned dose. Images were scored visually by 2 blinded readers for IQ and summed rest score (SRS). TPD and EF were assessed quantitatively. Results Mean activity was 134 MBq (3.62 mCi) for ULD-HE-SPECT (effective dose 1.15 mSv) and 278 MBq (7.50 mCi, 2.39 mSv) for SLD-A-SPECT. Overall IQ was superior for ULD-HE-SPECT (p<0.0001), with twice as many studies graded excellent quality. Extracardiac activity and overall perfusion assessment were similar. Between-method correlations were high for SRS (r=0.87), TPD (r=0.91), and EF (r=0.88). Conclusion ULD-HE-SPECT rest imaging correlates highly with SLD-A-SPECT. It has improved image quality, comparable extracardiac activity, and achieves radiation dose reduction to 1 mSv for a single injection. PMID:24982439

  17. Quadruple-first line drug resistance in Mycobacterium tuberculosis in Vietnam: What can we learn from genes?

    PubMed

    Nguyen, Huy Quang; Nguyen, Nhung Viet; Contamin, Lucie; Tran, Thanh Hoa Thi; Vu, Thuong Thi; Nguyen, Hung Van; Nguyen, Ngoc Lan Thi; Nguyen, Son Thai; Dang, Anh Duc; Bañuls, Anne-Laure; Nguyen, Van Anh Thi

    2017-06-01

    In Vietnam, a country with high tuberculosis (137/100.000 population) and multidrug-resistant (MDR)-TB burdens (7.8/100.000 population), little is known about the molecular signatures of drug resistance in general and more particularly of second line drug (SLD) resistance. This study is specifically focused on Mycobacterium tuberculosis isolates resistant to four first-line drugs (FLDs) that make TB much more difficult to treat. The aim is to determine the proportion of SLD resistance in these quadruple drug resistant isolates and the genetic determinants linked to drug resistance to better understand the genetic processes leading to quadruple and extremely drug resistance (XDR). 91 quadruple (rifampicin, isoniazid, ethambutol and streptomycin) FLD resistant and 55 susceptible isolates were included. Spoligotyping and 24-locus MIRU-VNTR techniques were performed and 9 genes and promoters linked to FLD and SLD resistance were sequenced. SLD susceptibility testing was carried out on a subsample of isolates. High proportion of quadruple-FLD resistant isolates was resistant to fluoroquinolones (27%) and second-line injectable drugs (30.2%) by drug susceptibility testing. The sequencing revealed high mutation diversity with prevailing mutations at positions katG315, inhA-15, rpoB531, embB306, rrs1401, rpsL43 and gyrA94. The sensitivity and specificity were high for most drug resistances (>86%), but the sensitivity was lower for injectable drug resistances (<69%). The mutation patterns revealed 23.1% of pre-XDR and 7.7% of XDR isolates, mostly belonging to Beijing family. The genotypic diversity and the variety of mutations reflect the existence of various evolutionary paths leading to FLD and SLD resistance. Nevertheless, particular mutation patterns linked to high-level resistance and low fitness costs seem to be favored. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. STS-55 German payload specialists Walter and Schlegel work in SL-D2 module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter, wearing special head gear, conducts Tissue Thickness and Compliance Along Body Axis salt-water balance experiment in the Spacelab Deutsche 2 (SL-D2) science module aboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Walter's activities in front of Rack 9 Anthrorack (AR) are monitored by German Payload Specialist 2 Hans Schlegel. Walter uses intravehicular activity (IVA) foot restraints. Walter and Schlegel represent the German Aerospace Research Establishment (DLR).

  19. STS-55 crewmembers pose with U.S. and German flags in SL-D2 module on OV-102

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 crewmembers pose with United States and German flags inside the Spacelab Deutsche 2 (SL-D2) science module located in the payload bay (PLB) of Columbia, Orbiter Vehicle (OV) 102. Wearing communications kit assembly headsets (HDSTs) are (left to right) Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross, MS3 Bernard A. Harris, Jr, German Payload Specialist 1 Ulrich Walter, and Payload Specialist 2 Hans Schlegel.

  20. Magnon and phonon dispersion, lifetime, and thermal conductivity of iron from spin-lattice dynamics simulations

    NASA Astrophysics Data System (ADS)

    Wu, Xufei; Liu, Zeyu; Luo, Tengfei

    2018-02-01

    In recent years, the fundamental physics of spin-lattice (e.g., magnon-phonon) interaction has attracted significant experimental and theoretical interests given its potential paradigm-shifting impacts in areas like spin-thermoelectrics, spin-caloritronics, and spintronics. Modelling studies of the transport of magnons and phonons in magnetic crystals are very rare. In this paper, we use spin-lattice dynamics (SLD) simulations to model ferromagnetic crystalline iron, where the spin and lattice systems are coupled through the atomic position-dependent exchange function, and thus the interaction between magnons and phonons is naturally considered. We then present a method combining SLD simulations with spectral energy analysis to calculate the magnon and phonon harmonic (e.g., dispersion, specific heat, and group velocity) and anharmonic (e.g., scattering rate) properties, based on which their thermal conductivity values are calculated. This work represents an example of using SLD simulations to understand the transport properties involving coupled magnon and phonon dynamics.

  1. High-fat/high-sucrose diet results in higher bone mass in aged rats.

    PubMed

    Minematsu, Akira; Nishii, Yasue; Sakata, Susumu

    2018-06-01

    Intake of high-fat/high-sucrose (HFS) diet or high fat diet influences bone metabolism in young rodents, but its effects on bone properties of aged rodents still remain unclear. This study aimed to examine the effects of HFS diet intake on trabecular bone architecture (TBA) and cortical bone geometry (CBG) in aged rats. Fifteen male Wistar rats over 1 year were randomly divided into two groups. One group was fed a standard laboratory diet (SLD) and the other group was fed a HFS diet for six months. The femur/tibia, obtained from both groups at the end of experimental period, were scanned by micro-computed tomography for TBA/CBG analyses. Serum biochemical analyses were also conducted. Body weight was significantly higher in the HFS group than in the SLD group. In both femur and tibia, the HFS group showed higher trabecular/cortical bone mass in reference to bone mineral content, volume bone mineral density and TBA/CBG parameters compared with the SLD group. In addition, serum calcium, inorganic phosphorus, total protein, triacylglycerol, HDL and TRACP-5b levels were significantly higher in the HFS group than in the SLD group. There were good correlations between body weight and bone parameters in the femur and tibia. These results suggest that HFS diet intake results in higher bone mass in aged rats. Such effects of HFS diet intake might have been induced by increased body weight.

  2. A laboratory investigation of colour changes in two contemporary resin composites on exposure to spices.

    PubMed

    Yew, H Z; Berekally, T L; Richards, L C

    2013-12-01

    The aim of this study was to evaluate colour stability upon exposure to spices of a nano-filled and a micro-hybrid resin composite finished either with Sof-Lex™ discs (SLD) or against plastic strips (PS). Forty cylindrical specimens of 3 mm thickness were fabricated from Filtek Supreme XT ™ (FS) and Gradia Direct X™ (GD). The top surface of each specimen was polished with SLD while the bottom surface was finished against PS. All samples were immersed in staining solutions (0.1% weight turmeric, paprika and tamarind) and distilled water at 37 °C. Colour after 0, 24, 72 and 168 hours of immersion was recorded with a reflection spectrophotometer using CIE L*a*b* parameters and the results were statistically analysed with repeated measures of ANOVA and Bonferroni post hoc tests. Among all the staining solutions tested, the highest colour deviation was obtained in the turmeric group. FS finished against PS showed significantly more colour changes compared to specimens polished with SLD, while GD finished against PS were found to be more resistant to colour changes. Within the limitations of this study all the spices tested have the potential to stain resin composites with turmeric causing the most significant discolouration. Micro-hybrid and nano-filled resin composites appeared to respond differently to staining by spices when either finished with PS or polished with SLD. © 2013 Australian Dental Association.

  3. Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord

    PubMed Central

    Weng, F J; Williams, R H; Hawryluk, J M; Lu, J; Scammell, T E; Saper, C B; Arrigoni, E

    2014-01-01

    Considerable electrophysiological and pharmacological evidence has long suggested an important role for acetylcholine in the regulation of rapid-eye-movement (REM) sleep. For example, injection of the cholinergic agonist carbachol into the dorsomedial pons produces an REM sleep-like state with muscle atonia and cortical activation, both of which are cardinal features of REM sleep. Located within this region of the pons is the sublaterodorsal nucleus (SLD), a structure thought to be both necessary and sufficient for generating REM sleep muscle atonia. Subsets of glutamatergic SLD neurons potently contribute to motor inhibition during REM sleep through descending projections to motor-related glycinergic/GABAergic neurons in the spinal cord and ventromedial medulla. Prior electrophysiological and pharmacological studies examining the effects of acetylcholine on SLD neurons have, however, produced conflicting results. In the present study, we sought to clarify how acetylcholine influences the activity of spinally projecting SLD (SLDsp) neurons. We used retrograde tracing in combination with patch-clamp recordings and recorded pre-and postsynaptic effects of carbachol on SLDsp neurons. Carbachol acted presynaptically by increasing the frequency of glutamatergic miniature excitatory postsynaptic currents. We also found that carbachol directly excited SLDsp neurons by activating an Na+–Ca2+ exchanger. Both pre-and postsynaptic effects were mediated by co-activation of M1 and M3 muscarinic receptors. These observations suggest that acetylcholine produces synergistic, excitatory pre-and postsynaptic responses on SLDsp neurons that, in turn, probably serve to promote muscle atonia during REM sleep. PMID:24344163

  4. Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord.

    PubMed

    Weng, F J; Williams, R H; Hawryluk, J M; Lu, J; Scammell, T E; Saper, C B; Arrigoni, E

    2014-04-01

    Considerable electrophysiological and pharmacological evidence has long suggested an important role for acetylcholine in the regulation of rapid-eye-movement (REM) sleep. For example, injection of the cholinergic agonist carbachol into the dorsomedial pons produces an REM sleep-like state with muscle atonia and cortical activation, both of which are cardinal features of REM sleep. Located within this region of the pons is the sublaterodorsal nucleus (SLD), a structure thought to be both necessary and sufficient for generating REM sleep muscle atonia. Subsets of glutamatergic SLD neurons potently contribute to motor inhibition during REM sleep through descending projections to motor-related glycinergic/GABAergic neurons in the spinal cord and ventromedial medulla. Prior electrophysiological and pharmacological studies examining the effects of acetylcholine on SLD neurons have, however, produced conflicting results. In the present study, we sought to clarify how acetylcholine influences the activity of spinally projecting SLD (SLDsp) neurons. We used retrograde tracing in combination with patch-clamp recordings and recorded pre- and postsynaptic effects of carbachol on SLDsp neurons. Carbachol acted presynaptically by increasing the frequency of glutamatergic miniature excitatory postsynaptic currents. We also found that carbachol directly excited SLDsp neurons by activating an Na(+)-Ca(2+) exchanger. Both pre- and postsynaptic effects were mediated by co-activation of M1 and M3 muscarinic receptors. These observations suggest that acetylcholine produces synergistic, excitatory pre- and postsynaptic responses on SLDsp neurons that, in turn, probably serve to promote muscle atonia during REM sleep.

  5. Development of high-polarization Fe/Ge neutron polarizing supermirror: Possibility of fine-tuning of scattering length density in ion beam sputtering

    NASA Astrophysics Data System (ADS)

    Maruyama, R.; Yamazaki, D.; Akutsu, K.; Hanashima, T.; Miyata, N.; Aoki, H.; Takeda, M.; Soyama, K.

    2018-04-01

    The multilayer structure of Fe/Si and Fe/Ge systems fabricated by ion beam sputtering (IBS) was investigated using X-ray and polarized neutron reflectivity measurements and scanning transmission electron microscopy with energy-dispersive X-ray analysis. The obtained result revealed that the incorporation of sputtering gas particles (Ar) in the Ge layer gives rise to a marked reduction in the neutron scattering length density (SLD) and contributes to the SLD contrast between the Fe and Ge layers almost vanishing for spin-down neutrons. Bundesmann et al. (2015) have shown that the implantation of primary Ar ions backscattered at the target is responsible for the incorporation of Ar particles and that the fraction increases with increasing ion incidence angle and increasing polar emission angle. This leads to a possibility of fine-tuning of the SLD for the IBS, which is required to realize a high polarization efficiency of a neutron polarizing supermirror. Fe/Ge polarizing supermirror with m = 5 fabricated under the same condition showed a spin-up reflectivity of 0.70 at the critical momentum transfer. The polarization was higher than 0.985 for the qz range where the correction for the polarization inefficiencies of the beamline works properly. The result of the polarized neutron reflectivity measurement suggests that the "magnetically-dead" layers formed at both sides of the Fe layer, together with the SLD contrast, play a critical role in determining the polarization performance of a polarizing supermirror.

  6. Second Line of Defense: Electronic Maintenance Reports, Local Maintenance Provider User Guide, Rev. 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leigh, Richard J.

    2012-09-01

    The Electronic Maintenance Report forms allow Local Maintenance Providers (LMP) and other program staff to enter maintenance information into a simple and secure system. This document describes the features and information required to complete the Maintenance Report forms. It is expected that all Corrective Maintenance Reports from LMPs will be submitted electronically into the SLD Portal. As an exception (e.g., when access to the SLD Portal is unavailable), Maintenance Reports can be submitted via a secure Adobe PDF form available through the Sustainability Manager assigned to each country.

  7. Subject Load-Harness Interaction During Zero-Gravity Treadmill Exercise

    NASA Technical Reports Server (NTRS)

    McCrory, Jean L.; Baron, Heidi A.; Derr, Janice A.; Davis, Brian L.; Cavanagh, Peter R.

    1996-01-01

    When astronauts exercise on orbit, a subject load device (SLD) must be used to return the subject back to the supporting surface. The load in the SLD needs to be transferred the body by a harness which typically distributes this load between the pelvis and We shoulders. Through the use of a zero-gravity simulator, this research compared subject comfort and ground reaction forces during treadmill running at three levels of subject load (60%,80%, and 100% of body weight) in two harness designs ("shoulder only" and "waist "and shoulder ").

  8. Experimental Study of Supercooled Large Droplet Impingement Effects

    NASA Technical Reports Server (NTRS)

    Papadakis, M.; Rachman, A.; Wong, S. C.; Hung, K. E.; Vu, G. T.

    2003-01-01

    Typically, ice accretion results from small supercooled droplets (droplets cooled below freezing), usually 5 to 50 microns in diameter, which can freeze upon impact with an aircraft surface. Recently, ice accretions resulting from supercooled large droplet (SLD) conditions have become a safety concern. Current ice accretion codes have been extensively tested for Title 14 Code of Federal Regulations Part 25, Appendix C icing conditions but have not been validated for SLD icing conditions. This report presents experimental methods for investigating large droplet impingement dynamics and for obtaining small and large water droplet impingement data.

  9. A method for integrating neuroimaging into genetic models of learning performance.

    PubMed

    Mehta, Chintan M; Gruen, Jeffrey R; Zhang, Heping

    2017-01-01

    Specific learning disorders (SLD) are an archetypal example of how clinical neuropsychological (NP) traits can differ from underlying genetic and neurobiological risk factors. Disparate environmental influences and pathologies impact learning performance assessed through cognitive examinations and clinical evaluations, the primary diagnostic tools for SLD. We propose a neurobiological risk for SLD with neuroimaging biomarkers, which is integrated into a genome-wide association study (GWAS) of learning performance in a cohort of 479 European individuals between 8 and 21 years of age. We first identified six regions of interest (ROIs) in temporal and anterior cingulate regions where the group diagnosed with learning disability has the least overall variation, relative to the other group, in thickness, area, and volume measurements. Although we used the three imaging measures, the thickness was the leading contributor. Hence, we calculated the Euclidean distances between any two individuals based on their thickness measures in the six ROIs. Then, we defined the relative similarity of one individual according to the averaged ranking of pairwise distances from the individuals to those in the SLD group. The inverse of this relative similarity is called the neurobiological risk for the individual. Single nucleotide polymorphisms in the AGBL1 gene on chromosome 15 had a significant association with learning performance at a genome-wide level. This finding was supported in an independent cohort of 2,327 individuals of the same demographic profile. Our statistical approach for integrating genetic and neuroimaging biomarkers can be extended into studying the biological basis of other NP traits. © 2016 WILEY PERIODICALS, INC.

  10. STS-55 German payload specialist Schlegel and MS3 Harris work in SL-D2 module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 2 Ulrich Walter, wearing special head gear, finds plenty of room to 'spread out' (head to the floor, feet at the ceiling) while conducting Tissue Thickness and Compliance Along Body Axis salt-water balance experiment in the Spacelab Deutsche 2 (SL-D2) science module aboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Schlegel represents the German Aerospace Research Establishment (DLR). In the background, Mission Specialist 3 (MS3) Bernard A. Harris, Jr monitors an experiment in Rack 11, an experiment rack.

  11. Spectroscopic analysis of the impact of oxidative stress on the structure of human serum albumin (HSA) in terms of its binding properties

    NASA Astrophysics Data System (ADS)

    Maciążek-Jurczyk, M.; Sułkowska, A.

    2015-02-01

    Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis (RA). Reactive oxygen species (ROS) are produced in the course of cellular oxidative phosphorylation and by activated phagocytic cells during oxidative bursts, exceed the physiological buffering capacity and result in oxidative stress. ROS result in oxidation of serum albumin, which causes a number of structural changes in the spatial structure, may influence the binding and cause significant drug interactions, particularly in polytherapy. During the oxidation modification of amino acid residues, particularly cysteine and methionine may occur. The aim of the study was to investigate the influence of oxidative stress on human serum albumin (HSA) structure and evaluate of possible alterations in the binding of the drug to oxidized human serum albumin (oHSA). HSA was oxidized by a chloramine-T (CT). CT reacts rapidly with sulfhydryl groups and at pH 7.4 the reaction was monitored by spectroscopic techniques. Modification of free thiol group in the Cys residue in HSA was quantitatively determined by the use of Ellman's reagent. Changes of albumin conformation were examined by comparison of modified (oHSA) and nonmodified human serum albumin (HSA) absorption spectra, emission spectra, red-edge shift (REES) and synchronous spectroscopy. Studies of absorption spectra indicated that changes in the value of absorbance associated with spectral changes in the region of 200-250 nm involve structural alterations in peptide backbone conformation. Synchronous fluorescence spectroscopy technique confirmed changes of position of tryptophanyl and tyrosyl residues fluorescent band caused by CT. Moreover analysis of REES effect allowed to observe structural changes caused by CT in the region of the hydrophobic pocket containing the tryptophanyl residue. Effect of oxidative stress on binding of anti-rheumatic drugs, sulfasalazine (SSZ) and sulindac (SLD) in the high and low affinity binding sites was investigated by spectrofluorescence, ITC and 1H NMR spectroscopy, respectively. SSZ and SLD change the affinity of each other to the binding site in non- and modified human serum albumin. The presence of SLD causes the increase of association constant (Ka) of SSZ-oHSA system and the strength of binding and the stability of the complexes has been observed while in the presence of SSZ a displacement of SLD from the SLD-HSA has been recorded. The analysis of 1H NMR spectral parameters i.e. changes of chemical shifts of the drug indicate that the presence of SSZ and SLD have a mutual influence on changes in the affinity of human serum albumin binding site and this competition takes place not only due to the additional drug but also to the oxidation of HSA.

  12. Specific language disorders and season of birth: underlying environmental factors or chance findings?

    PubMed

    Ghezzo, Alessandro; Chiappedi, Matteo; Ballerini, Antonina; Seragni, Giorgio; Zanette, Michela; Conti, Chiara; Stefanini, Maria Chiara; Ferrari-Ginevra, Oreste; Spelta, Patrizia; Angelini, Lucia; Beghi, Ettore

    2012-01-01

    The medical records of 358 children and adolescents with specific language disorders (SLD; 122 girls and 236 boys) seen in rehabilitation centers from Northern and Central Italy were examined to compare season of birth in these cases to those of the Italian population. Exposure was calculated using univariate and multivariate odds ratios (ORs) and 95% confidence intervals (CIs). Compared to the Italian population, patients with SLD had a 1.67 (95% CI [1.35-2.07]) chance of birth in October-December. Independent predictors were younger age at inclusion and being firstborn. Different neurobiological hypotheses can be drawn to explain these findings.

  13. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baird, K.; SLD Collaboration

    The authors have measured production fractions and spectra for {pi}{sup {+-}}, K{sup {+-}} and p, and production spectra for K{sup 0} and {Lambda}{sup 0} in both hadronic Z{sup 0} decays and a Z{sup 0} {yields} light quark (uds) subset at SLD. The SLD Cherenkov Ring Imaging Detector was used to identify charged hadrons. The CCD vertex detector was used to select the enriched uds sample. For the global sample, the results are consistent with previous experiments. The authors observe a clear flavor dependence in production spectra, but only a small effect in hadron fractions and {xi} = ln(1/x{sub p}) peakmore » positions.« less

  14. A Database of Supercooled Large Droplet Ice Accretions [Supplement

    NASA Technical Reports Server (NTRS)

    VanZante, Judith Foss

    2007-01-01

    A unique, publicly available database regarding supercooled large droplet (SLD) ice accretions has been developed in NASA Glenn's Icing Research Tunnel. Identical cloud and flight conditions were generated for five different airfoil models. The models chosen represent a variety of aircraft types from the horizontal stabilizer of a large transport aircraft to the wings of regional, business, and general aviation aircraft. In addition to the standard documentation methods of 2D ice shape tracing and imagery, ice mass measurements were also taken. This database will also be used to validate and verify the extension of the ice accretion code, LEWICE, into the SLD realm.

  15. Comparison of LEWICE and GlennICE in the SLD Regime

    NASA Technical Reports Server (NTRS)

    Wright, William B.; Potapczuk, Mark G.; Levinson, Laurie H.

    2008-01-01

    A research project is underway at the NASA Glenn Research Center (GRC) to produce computer software that can accurately predict ice growth under any meteorological conditions for any aircraft surface. This report will present results from two different computer programs. The first program, LEWICE version 3.2.2, has been reported on previously. The second program is GlennICE version 0.1. An extensive comparison of the results in a quantifiable manner against the database of ice shapes that have been generated in the GRC Icing Research Tunnel (IRT) has also been performed, including additional data taken to extend the database in the Super-cooled Large Drop (SLD) regime. This paper will show the differences in ice shape between LEWICE 3.2.2, GlennICE, and experimental data. This report will also provide a description of both programs. Comparisons are then made to recent additions to the SLD database and selected previous cases. Quantitative comparisons are shown for horn height, horn angle, icing limit, area, and leading edge thickness. The results show that the predicted results for both programs are within the accuracy limits of the experimental data for the majority of cases.

  16. The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep

    PubMed Central

    Chen, Michael C.

    2016-01-01

    Abstract Rapid eye movement (REM) sleep is a recurring part of the sleep–wake cycle characterized by fast, desynchronized rhythms in the electroencephalogram (EEG), hippocampal theta activity, rapid eye movements, autonomic activation and loss of postural muscle tone (atonia). The brain circuitry governing REM sleep is located in the pontine and medullary brainstem and includes ascending and descending projections that regulate the EEG and motor components of REM sleep. The descending signal for postural muscle atonia during REM sleep is thought to originate from glutamatergic neurons of the sublaterodorsal nucleus (SLD), which in turn activate glycinergic pre‐motor neurons in the spinal cord and/or ventromedial medulla to inhibit motor neurons. Despite work over the past two decades on many neurotransmitter systems that regulate the SLD, gaps remain in our knowledge of the synaptic basis by which SLD REM neurons are regulated and in turn produce REM sleep atonia. Elucidating the anatomical, cellular and synaptic basis of REM sleep atonia control is a critical step for treating many sleep‐related disorders including obstructive sleep apnoea (apnea), REM sleep behaviour disorder (RBD) and narcolepsy with cataplexy. PMID:27060683

  17. Neurorehabilitation applied to specific learning disability: Study of a single case.

    PubMed

    Bilancia, Giovanni; Marazzi, Moreno; Filippi, Davide

    2015-01-01

    Specific Learning Disorders (SLD) therefore represent chronic, not temporary disorders with varying degrees of expression throughout life. The beginning of imaging, anatomy and genetics studies have made it possible to investigate the brain organization of individuals suffering from SLD (Deheane, 2009). The purpose of this paper is to describe a treatment method for reading and writing disorders through an intervention based on the integration of a sublexical method and a neuropsychological approach, with assistive technologies in the study of a single case. The protocol is based on the modularization theory (Karmiloff-Smith, 1990). The data presented in this paper with a A-B-A basic experimental drawing. This study confirms the degree of effectiveness of the treatments based on the automated identification of syllables and words together with the integrated enhancement of neuropsychological aspects such as visual attention and phonological loop (Benso, 2008), although in the follow-up condition only some abilities maintain the progress achieved. As previously mentioned, the SLD represents a chronic disorder, consequently the treatment does not solve the root cause of the problem, but can grant a use of the process decidedly more instrumental to everyday life.

  18. Particle Trajectory and Icing Analysis of the E(sup 3) Turbofan Engine Using LEWICE3D Version 3

    NASA Technical Reports Server (NTRS)

    Bidwell, Colin S.

    2011-01-01

    Particle trajectory and ice shape calculations were made for the Energy Efficient Engine (E(sup 3)) using the LEWICE3D Version 3 software. The particle trajectory and icing computations were performed using the new "block-to-block" collection efficiency method which has been incorporated into the LEWICE3D Version 3 software. The E(sup 3) was developed by NASA and GE in the early 1980 s as a technology demonstrator and is representative of a modern high bypass turbofan engine. The E(sup 3) flow field was calculated using the NASA Glenn ADPAC turbomachinery flow solver. Computations were performed for the low pressure compressor of the E(sup 3) for a Mach 0.8 cruise condition at 11,887 m assuming a standard warm day for three drop sizes and two drop distributions typically used in aircraft design and certification. Particle trajectory computations were made for water drop sizes of 5, 20, and 100 microns. Particle trajectory and ice shape predictions were made for a 20 micron Langmuir-D distribution and for a 92 mm Super-cooled Large Droplet (SLD) distribution with and without splashing effects for a Liquid Water Content (LWC) of 0.3 g/cu m and an icing time of 30 min. The E3 fan and spinner combination proved to be an effective ice removal mechanism as they removed greater than 36 percent of the mass entering the inlet for the icing cases. The maximum free stream catch fraction for the fan and spinner combination was 0.60 while that on the elements downstream of the fan was 0.03. The non-splashing trajectory and collection efficiency results showed that as drop size increased impingement rates increased on the spinner and fan leaving less mass to impinge on downstream components. The SLD splashing case yielded more mass downstream of the fan than the SLD non-splashing case due to mass being splashed from the upstream inlet lip, spinner and fan components. The ice shapes generated downstream of the fan were either small or nonexistent due to the small available mass and evaporation except for the 92 m SLD splashing case. Relatively large ice shapes were predicted for internal guide vane #1 and rotor #1 for the 92 m SLD splashing case due to re-impingement of splashed mass.

  19. Super Cooled Large Droplet Analysis of Several Geometries Using LEWICE3D Version 3

    NASA Technical Reports Server (NTRS)

    Bidwell, Colin S.

    2011-01-01

    Super Cooled Large Droplet (SLD) collection efficiency calculations were performed for several geometries using the LEWICE3D Version 3 software. The computations were performed using the NASA Glenn Research Center SLD splashing model which has been incorporated into the LEWICE3D Version 3 software. Comparisons to experiment were made where available. The geometries included two straight wings, a swept 64A008 wing tip, two high lift geometries, and the generic commercial transport DLR-F4 wing body configuration. In general the LEWICE3D Version 3 computations compared well with the 2D LEWICE 3.2.2 results and with experimental data where available.

  20. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Muller, D.; SLD Collaboration

    The authors present studies of leading particle production in Z{sup 0} decays into light, c, and b quarks performed with the SLD experiment at SLAC. The SLD precision vertex detector was exploited to tag light-flavor events, to tag charmed meson vertices and separate the prompt and B-decay components, and to reconstruct B-hadrons partially. The relative production of prompt pseudoscalar and vector D-mesons was measured to be P{sub V} = 0.53 {+-} 0.06(stat.) {+-} 0.02(syst.) (preliminary). The shape of the B-hadron energy spectrum was found to be consistent with the predictions of a number of models, and the average energy fractionmore » was measured to be = 0.697 {+-} 0.012(stat.) {+-} 0.028(syst.) (preliminary). Separation of light quark and antiquark jets was achieved using the highly polarized SLC electron beam, and hadrons were identified using the SLD Cherenkov Ring Imaging Detector. Production of particles and antiparticles in quark jets was compared, allowing the first direct observation of leading particles in e{sup +}e{sup {minus}} {r_arrow} u{anti u}, d{anti d}, s{anti s} events. More high momentum baryons and K{sup {minus}}`s than antibaryons and K{sup +}`s were observed, providing evidence for leading baryon and kaon production, as well as for strangeness suppression at high momentum.« less

  1. Cost of speech-language interventions for children and youth with foetal alcohol spectrum disorder in Canada.

    PubMed

    Popova, Svetlana; Lange, Shannon; Burd, Larry; Shield, Kevin; Rehm, Jürgen

    2014-12-01

    This study, which is part of a large economic project on the overall burden and cost associated with Foetal Alcohol Spectrum Disorder (FASD) in Canada, estimated the cost of 1:1 speech-language interventions among children and youth with FASD for Canada in 2011. The number of children and youth with FASD and speech-language disorder(s) (SLD), the distribution of the level of severity, and the number of hours needed to treat were estimated using data from the available literature. 1:1 speech-language interventions were computed using the average cost per hour for speech-language pathologists. It was estimated that ˜ 37,928 children and youth with FASD had SLD in Canada in 2011. Using the most conservative approach, the annual cost of 1:1 speech-language interventions among children and youth with FASD is substantial, ranging from $72.5 million to $144.1 million Canadian dollars. Speech-language pathologists should be aware of the disproportionate number of children and youth with FASD who have SLD and the need for early identification to improve access to early intervention. Early identification and access to high quality services may have a role in decreasing the risk of developing the secondary disabilities and in reducing the economic burden of FASD on society.

  2. Evaluation of molecular volume change of block copolymer depending on temperature: A SANS study

    DOE PAGES

    Kim, Tae-Hwan; Do, Changwoo; Han, Young-Soo

    2017-12-24

    Amphiphilic Pluronic triblock copolymers form various self-assembled structures such as sphere, cylinder, lamellae and so on, depending on temperature, leading to the increase of hydrophobicity of block copolymers. However, the effective molecular volume change of the block copolymer has not been fully exploited yet, when temperature increases. Here in this paper, we have investigated the effective molecular volume change of the block copolymer upon heating by using the contrast variation small angle neutron scattering. The scattering length densities (SLDs) of the block copolymer were experimentally obtained from the neutron scattering contrast variation method between the solvent and the block copolymermore » at varying temperature. Even though the SLD, which is the intrinsic property of the material, should not be changed by temperature elevation, it was dependent on temperature, indicating that the molecular volume is changed. Therefore, we obtained the increase rate of the molecular volume change of the block copolymer (the effective molecular volume change) from the comparison of the calculated SLD and the standard SLD, which is evaluated by plotting the SANS intensity at the first order Bragg peak as the function of temperature at each volume fraction of D 2O and H 2O that is about 25.5%–51.3% depending on temperature.« less

  3. Evaluation of molecular volume change of block copolymer depending on temperature: A SANS study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Tae-Hwan; Do, Changwoo; Han, Young-Soo

    Amphiphilic Pluronic triblock copolymers form various self-assembled structures such as sphere, cylinder, lamellae and so on, depending on temperature, leading to the increase of hydrophobicity of block copolymers. However, the effective molecular volume change of the block copolymer has not been fully exploited yet, when temperature increases. Here in this paper, we have investigated the effective molecular volume change of the block copolymer upon heating by using the contrast variation small angle neutron scattering. The scattering length densities (SLDs) of the block copolymer were experimentally obtained from the neutron scattering contrast variation method between the solvent and the block copolymermore » at varying temperature. Even though the SLD, which is the intrinsic property of the material, should not be changed by temperature elevation, it was dependent on temperature, indicating that the molecular volume is changed. Therefore, we obtained the increase rate of the molecular volume change of the block copolymer (the effective molecular volume change) from the comparison of the calculated SLD and the standard SLD, which is evaluated by plotting the SANS intensity at the first order Bragg peak as the function of temperature at each volume fraction of D 2O and H 2O that is about 25.5%–51.3% depending on temperature.« less

  4. Colorimetric determination of sildenafil citrate (Viagra) through ion-associate complex formation.

    PubMed

    Amin, Alaa S; Moustafa, Moustafa E; El-Dosoky, Reham

    2009-01-01

    A simple, quick, accurate, and sensitive colorimetric method is described for the determination of sildenafil citrate (SLD). The method is based on the reaction of SLD with Congo Red, Sudan II, and Gentian Violet in buffered aqueous solutions at pH 2.5, 6.5, and 11.0, respectively, to give highly colored soluble ion-associate complex species; the colored products are quantitated colorimetrically at 523, 554, and 569 nm, respectively. The various experimental conditions were optimized. The stoichiometric ratio was found to be 1:1 for all ion associates; the calculated logarithmic stability constants were 8.51, 7.79, and 5.58, respectively. Beer's law was obeyed over the concentration range of 0.2-7.0 microg/mL, whereas the Ringbom optimum concentration range was 0.4-6.5 microg/mL. Values for molar absorptivity, Sandell sensitivity, and detection and quantification limits were also calculated. The proposed method was successfully applied to the determination of SLD in Viagra tablets and in serum samples by using the technique of standard additions with mean accuracy values of 100.06 +/- 1.14, 99.87 +/- 0.70, and 99.86 +/- 0.97% for Viagra tablets and 99.88 +/- 0.60, 99.90 +/- 0.90, and 100.24 +/- 0.80% for serum samples, respectively.

  5. Analysis of Differentially Expressed Genes and Signaling Pathways Related to Intramuscular Fat Deposition in Skeletal Muscle of Sex-Linked Dwarf Chickens

    PubMed Central

    Ye, Yaqiong; Lin, Shumao; Mu, Heping; Tang, Xiaohong; Ou, Yangdan; Chen, Jian; Ma, Yongjiang; Li, Yugu

    2014-01-01

    Intramuscular fat (IMF) plays an important role in meat quality. However, the molecular mechanisms underlying IMF deposition in skeletal muscle have not been addressed for the sex-linked dwarf (SLD) chicken. In this study, potential candidate genes and signaling pathways related to IMF deposition in chicken leg muscle tissue were characterized using gene expression profiling of both 7-week-old SLD and normal chickens. A total of 173 differentially expressed genes (DEGs) were identified between the two breeds. Subsequently, 6 DEGs related to lipid metabolism or muscle development were verified in each breed based on gene ontology (GO) analysis. In addition, KEGG pathway analysis of DEGs indicated that some of them (GHR, SOCS3, and IGF2BP3) participate in adipocytokine and insulin signaling pathways. To investigate the role of the above signaling pathways in IMF deposition, the gene expression of pathway factors and other downstream genes were measured by using qRT-PCR and Western blot analyses. Collectively, the results identified potential candidate genes related to IMF deposition and suggested that IMF deposition in skeletal muscle of SLD chicken is regulated partially by pathways of adipocytokine and insulin and other downstream signaling pathways (TGF-β/SMAD3 and Wnt/catenin-β pathway). PMID:24757673

  6. Learning Disabilities and Emotional Intelligence.

    PubMed

    Zysberg, Leehu; Kasler, Jon

    2017-07-04

    The literature is conflicted around the subject of the emotional abilities of individuals with Specific Learning Disabilities (SLDs): While many claim cognitive challenges are associated with emotional difficulties, some suggest emotional and interpersonal abilities are not compromised in such disorders and may help individuals compensate and cope effectively with the challenges they meet in learning environments. Two studies explored differences in emotional intelligence (EI) between young adults with and without SLD. Two samples (matched on gender, approximate age, and program of study; n = 100, and unmatched; n = 584) of college students took self-report and performance-based tests of EI (Ability-EI) as well as a measure of self-esteem and demographics associated with college performance (e.g.: SAT scores, gender, etc.). The results showed that while SAT scores and ability emotional intelligence (Ability-EI) were associated with college GPA, Ability-EI did not differ between the two groups, while self-report measures of EI and self-esteem did show differences, with the group with learning disabilities ranking lower. The effects remained stable when we controlled for demographics and potential intervening factors. The results suggest that EI may play a protective role in the association between background variables and college attainment in students with SLD. The results may provide a basis for interventions to empower students with SLD in academia.

  7. Response Assessment in Paediatric Phase I Trials According to RECIST Guidelines: Survival Outcomes, Patterns of Progression and Relevance of Changes in Tumour Measurements.

    PubMed

    Carceller, Fernando; Bautista, Francisco J; Fowkes, Lucy A; Marshall, Lynley V; Sirvent, Sara I; Chisholm, Julia C; Pearson, Andrew D J; Koh, Dow-Mu; Moreno, Lucas

    2016-08-01

    RECIST guidelines constitute the reference for radiological response assessment in most paediatric trials of anticancer agents. However, these criteria have not been validated in children. We evaluated the outcomes and patterns of progression of children/adolescents enrolled in phase I trials in two paediatric drug development units. Patients aged ≤21 assessed with RECIST (v1.0 or v1.1) were eligible. Clinico-radiological data were analysed using Mann-Whitney U and log-rank tests to correlate response categories and sum of longest diameters (SLD) with time-to-event variables and overall survival (OS). Sixty-one patients (71 enrolments) were evaluated; median age: 12.7 years (range, 3.1-20.9). Overall, 7% achieved complete/partial response (n = 5) and 31% disease stabilisation (n = 22). Median (95% CI) OS (in months) was 29.1 (27.6-30.6) with complete/partial response, 8.9 (2.0-15.8) with stable disease and 2.8 (2.3-3.3) with disease progression (P < 0.001); 32.6% patients with measurable disease presented exclusive progression of existing non-target lesions and/or new lesions. The change in SLD at best response showed a linear correlation with duration of response (r = -0.605; P = 0.004) and time on trial (r = -0.61; P = 0.003), but the change in SLD at progression did not correlate with time to progression (r = -0.219; P = 0.206). Response assessment according to RECIST correlated with OS in children/adolescents treated on phase I trials. The reduction in SLD at best response correlated with more prolonged responses. Tumour size did not constitute an optimal method to assess disease progression in one third of patients with measurable disease. Further refinement of current response assessment guidelines will enable the development of paediatric-specific radiological criteria. © 2016 Wiley Periodicals, Inc.

  8. Optimisation of the size variation threshold for imaging evaluation of response in patients with platinum-refractory advanced transitional cell carcinoma of the urothelium treated with vinflunine.

    PubMed

    Krajewski, Katherine M; Fougeray, Ronan; Bellmunt, Joaquim; Pons, Francesc; Schutz, Fabio A B; Rosenberg, Jonathan E; Salhi, Yacine; Choueiri, Toni K

    2012-07-01

    Vinflunine (VFL) has been approved in the European Union for second-line treatment of advanced transitional cell carcinoma of the urothelial tract (TCCU) in patients who progress after a platinum based regimen. However, very few patients achieve response by response evaluation criteria in solid tumours (RECIST). Therefore, another 'response' threshold may be more useful than RECIST 1.0 in this setting. One hundred and seventy nine patients with advanced TCCU treated with second-line VFL therapy had chest Computed Tomography (CT) and abdominal/pelvic CT or MRI performed at baseline and at first follow-up (6 weeks ± 3 days) after therapy initiation. Tumour measurements and response by RECIST 1.0 were correlated with overall survival (OS). Kaplan-Meier and receiver operating characteristic (ROC) analysis were then used to determine the optimal size threshold to define 'responders'. Impact of adverse prognostic factors including Eastern Cooperative Oncology Group Performance Status (ECOG PS) >0, Hb <10 g/dL, and liver metastases was analysed. Tumour response included 13 partial responses (PR) by RECIST 1.0 and 52 patients with ≥ 10% decrease in the sum of longest diameters. Responders by RECIST 1.0 did not have a statistically significant improvement in OS, while patients with sum long axis diameter (SLD) reduction of ≥ 10% had a longer OS than those with SLD reduction of <10%: 11.3 versus 6.9 months (log rank p=0.0224). ROC analysis yielded ≥ 10% decrease in SLD as the optimal size change correlating with OS. These results persisted on multivariate analysis. In the study population, a ≥ 10% reduction in SLD at first follow-up imaging is a better early predictor of outcome than RECIST. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Combinatorial metabolic engineering of industrial Gluconobacter oxydans DSM2343 for boosting 5-keto-D-gluconic acid accumulation.

    PubMed

    Yuan, Jianfeng; Wu, Mianbin; Lin, Jianping; Yang, Lirong

    2016-05-17

    L-(+)-tartaric acid (L-TA) is an important organic acid, which is produced from the cream of tartar or stereospecific hydrolysis of the cis-epoxysuccinate. The former method is limited by the availability of raw material and the latter is dependent on the petrochemical material. Thus, new processes for the economical preparation of L-TA from carbohydrate or renewable resource would be much more attractive. Production of 5-keto-D-gluconate (5-KGA) from glucose by Gluconobacter oxydans is the first step to produce L-TA. The aim of this work is to enhance 5-KGA accumulation using combinatorial metabolic engineering strategies in G. oxydans. The sldAB gene, encoding sorbitol dehydrogenase, was overexpressed in an industrial strain G. oxydans ZJU2 under a carefully selected promoter, P0169. To enhance the efficiency of the oxidation by sldAB, the coenzyme pyrroloquinoline quinone (PQQ) and respiratory chain were engineered. Besides, the role in sldAB overexpression, coenzyme and respiratory chain engineering and their subsequent effects on 5-KGA production were investigated. An efficient, stable recombinant strain was constructed, whereas the 5-KGA production could be enhanced. By self-overexpressing the sldAB gene in G. oxydans ZJU2 under the constitutive promoter P0169, the resulting strain, G. oxydans ZJU3, produced 122.48 ± 0.41 g/L of 5-KGA. Furthermore, through the coenzyme and respiratory chain engineering, the titer and productivity of 5-KGA reached 144.52 ± 2.94 g/L and 2.26 g/(L · h), respectively, in a 15 L fermenter. It could be further improved the 5-KGA titer by 12.10 % through the fed-batch fermentation under the pH shift and dissolved oxygen tension (DOT) control condition, obtained 162 ± 2.12 g/L with the productivity of 2.53 g/(L · h) within 64 h. The 5-KGA production could be significantly enhanced with the combinatorial metabolic engineering strategy in Gluconobacter strain, including sldAB overexpression, coenzyme and respiratory chain engineering. Fed-batch fermentation could further enlarge the positive effect and increase the 5-KGA production. All of these demonstrated that the robust recombinant strain can efficiently produce 5-KGA in larger scale to fulfill the industrial production of L-TA from 5-KGA.

  10. Production of large numbers of hybridomas producing monoclonal antibodies against rat IgE using mast cell-deficient w/wv and sl/sld strains of mice.

    PubMed

    Rup, B J

    1989-08-15

    A number of different mouse strains and immunization protocols were used to attempt to make monoclonal antibodies against rat IgE for use in studies of the structure, biological activities and regulation of this class of antibody. Successful production of large numbers of monoclonal antibodies was achieved when mast cell deficient (w/wv and sl/sld) but not conventional (BALB/c, CAF1 or SJL) mice were used. These results suggest that the poor response of conventional strains of mice to rat IgE may be due to the presence of mast cells bearing high affinity receptors for IgE in these mice.

  11. A Preliminary Study of Ice-Accretion Scaling for SLD Conditions

    NASA Technical Reports Server (NTRS)

    Anderson, David N.

    2003-01-01

    Proposed changes to aircraft icing certification rules are being considered by European, Canadian, and American regulatory agencies to include operation in super-cooled large droplet conditions (SLD). This paper reports results of an experimental study in the NASA Glenn Icing Research Tunnel (IRT) to evaluate how well scaling methods developed for Appendix C conditions might apply to SLD conditions. Until now, scaling studies have been confined to the FAA FAR-25 Appendix C envelope of atmospheric cloud conditions. Tests were made in which it was attempted to scale to a droplet MVD of 50 microns from clouds having droplet MVDs of 175, 120, 100, and 70 microns. Scaling was based on the Ruff method with scale velocities found either by maintaining constant Weber number or by using the average of the velocities obtained by maintaining constant Weber number and constant Reynolds number. Models were unswept NACA 0012 wing sections. The reference model had a chord of 91.4 cm. Scale models had chords of 91.4, 80.0, and 53.3 cm. Tests were conducted with reference airspeeds of 100 and 150 kt (52 and 77 m/s) and with freezing fractions of 1.0, 0.6, and 0.3. It was demonstrated that the scaled 50-micron cloud simulated well the non-dimensional ice shapes accreted in clouds with MVD's of 120 microns or less.

  12. From bench to bed: putative animal models of REM sleep behavior disorder (RBD).

    PubMed

    Krenzer, Martina; Lu, Jun; Mayer, Geert; Oertel, Wolfgang

    2013-04-01

    REM behavior disorder (RBD) is a parasomnia characterized by REM sleep without atonia, leading to abnormal and potentially injurious behavior during REM sleep. It is considered one of the most specific predictors of neurodegenerative disorders, such as Parkinson's disease. In this paper, we provide an overview of animal models contributing to our current understanding of REM-associated atonia, and, as a consequence, the pathophysiology of RBD. The generator of REM-associated atonia is located in glutamatergic neurons of the pontine sublaterodorsal nucleus (SLD), as shown in cats, rats and mice. These findings are supported by clinical cases of patients with lesions of the homologous structure in humans. Glutamatergic SLD neurons, presumably in conjunction with others, project to (a) the ventromedial medulla, where they either directly target inhibitory interneurons to alpha motor neurons or are relayed, and (b) the spinal cord directly. At the spinal level, alpha motor neurons are inhibited by GABAergic and glycinergic interneurons. Our current understanding is that lesions of the glutamatergic SLD are the key factor for REM sleep behavior disorder. However, open questions remain, e.g. other features of RBD (such as the typically aggressive dream content) or the frequent progression from idiopathic RBD to neurodegenerative disorders, to name only a few. In order to elucidate these questions, a constant interaction between basic and clinical researchers is required, which might, ultimately, create an early therapeutic window for neurodegenerative disorders.

  13. True Experimental Design.

    ERIC Educational Resources Information Center

    Huck, Schuyler W.

    1991-01-01

    This poem, with stanzas in limerick form, refers humorously to the many threats to validity posed by problems in research design, including problems of sample selection, data collection, and data analysis. (SLD)

  14. Project Delivery Methods.

    ERIC Educational Resources Information Center

    Dolan, Thomas G.

    2003-01-01

    Describes project delivery methods that are replacing the traditional Design/Bid/Build linear approach to the management, design, and construction of new facilities. These variations can enhance construction management and teamwork. (SLD)

  15. On Sternberg's "Reply to Gottfredson."

    ERIC Educational Resources Information Center

    Gottfredson, Linda S.

    2003-01-01

    Comments that R. Sternberg does not address criticisms previously made by L. Gottfredson, but rather discusses his theory of successful intelligence and answers only self-posed objections from unspecified critics. (SLD)

  16. Hadronic charmless B decays at the SLD

    NASA Astrophysics Data System (ADS)

    Reinertsen, Per Lasse

    Rare decays of beauty particles were studied in several two-body exclusive hadronic charmless modes using the 19.4 pb -1 Z-pole data collected with the SLD detector at SLAC from 1993 to 1998. These decays are mediated by both tree level b-->u and one-loop penguin b-->s,d transitions. Upper limits for the branching ratios are set for the investigated modes Bs, B0-->P+P- , B+-->VP+ and Bs, B0-->VV , where the pseudoscalar particle P+ is either p+ or K+ and the vector particle V is either r0,K*0 or f . Using an event selection algorithm consisting of a set of hard cuts combined with a set of discriminator functions, the efficiencies range between 24%, and 37% with near zero background.

  17. ERPs While Judging Meaningfulness of Sentences with and without Homonym or Morpheme Spelling Foils: Comparing 4th to 9th Graders with and without Spelling Disabilities

    PubMed Central

    Richards, Todd; Pettet, Mark; Askren, Katie; Grabowski, Tom; Yagle, Kevin; Wallis, Peter; Northey, Mary; Abbott, Robert; Berninger, Virginia

    2016-01-01

    Thirteen students with and twelve students without spelling disabilities judged whether sentences (1/3 all correct spellings, 1/3 with homonym foil, 1/3 with morpheme foil) were meaningful while event-related potentials (ERPs) were measured with EGI Geodesic EEG System 300 (128-channel hydro-cell nets). For N400, Rapid Automatic Switching (RAS) correlated with comprehending sentences with homonym foils in control group but with morpheme foils in SLD group. For P600, dictated spelling correlated with comprehending sentences with morpheme foils in the control group but solving anagrams with homonym foils in the SLD group. Educational significance and neuropsychological significance of these contrasting results are discussed. PMID:28657362

  18. Pedagogy and Political (Dis)Engagement.

    ERIC Educational Resources Information Center

    Spiezio, K. Edward

    2002-01-01

    Describes the ways in which educators can play a leading role in promoting civic engagement through curricular and institutional innovations in which students encounter the theory and practice of participatory democracy. (SLD)

  19. Putting the APA "Publication Manual" in Context. Commentary.

    ERIC Educational Resources Information Center

    Russo, Nancy Felipe

    1999-01-01

    Explores feminist criticism of the "Publications Manual" of the American Psychological Association and the ways in which feminist researchers have negotiated changes in the language of this style guide. (SLD)

  20. Measurement of the Z0 → $$s\\bar{s}$$ Coupling at the SLD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Staengle, Hermann

    1999-11-24

    This dissertation presents a direct measurement of the parity-violating coupling of the Z{sup 0} to strange quarks, A{sub s}, derived from e{sup +}e{sup -} collision data containing approximately 550,000 hadronic decays of polarized Z{sup 0} bosons. Data were recorded with the SLC Large Detector (SLD) at the SLAC Linear Collider (SLC) between 1993 and 1998 with an average electron beam polarization of 73% and 74% during the 1993-5 and 1996-8 run periods, respectively. Making use of several unique features of the SLC and SLD, this measurement relies on a new generation particle identification system, the Cherenkov Ring Imaging Detector, tomore » test the Standard Model prediction of universality in the coupling of the Z{sup 0} to down-type quarks. Polarized Z{sup 0} --> s anti-s events are tagged by the presence in each event hemisphere of a high-momentum K {+-}, K{sub s}{sup 0} or Lambda{sup 0}/ anti-Lambda{sup 0} identified using particle identification and/or a mass tag. The background from heavy flavor events is suppressed with the CCD-based vertex detector. The event thrust axis is signed with the strangeness of the tagged particle to point in the direction of the initial s quark. The coupling A{sub s} is derived from a maximum likelihood fit to the polar angle distributions of the tagged s quark measured with left- and right-handed electron beams. To reduce the model dependence of the measurement, the background from u anti-u and d anti-d events as well as the analyzing power of the method for s anti-s events are constrained from the data. We obtain A{sub s} = 0.86 {+-} 0.08(stat.) {+-} 0.05(syst.). The result is consistent with both the Standard Model prediction and previous bottom quark coupling mA{sub b}, measurements performed by SLD and LEP, and therefore supports the predicted universality of the Z{sup 0} to down-type quark couplings.« less

  1. The hamster clock phase-response curve from summerlike light:dark cycles and its role in daily and seasonal timekeeping.

    PubMed

    Alleva, John J; Alleva, Frederic R

    2002-11-01

    We address the subject of entrainment of the hamster clock by the day:night cycle in summer when the sun sets after 6 PM and rises before 6 AM (nights < 12 h). Summer day:night cycles were simulated by 6 light:dark (LD) cycles with D < 12 h (summerlike, SLD) ranging from SLD 12.5 h:11.5 h (D, 6:15 PM-5:45 AM) to 18 h:6 h (D, 9 PM-3 AM). These are the near limiting SLDs for constant PM timing (entrainment) of behavioral estrus and wheel running in hamsters. The onset of estrus was observed every 4 d in the same hamsters as a phase marker of their 24 h clock. On the day before an experimental estrus, preceded and followed by control onsets, a dark period was imposed to cover a putative 6 PM-6 AM light-sensitive period (LSP). This was scanned with a light pulse (and periodic 5 sec bell alarms) lasting 5-240 min. Shifts in onset of estrus on the next day were plotted vs. the end of the light pulse for PM times ("dusk") and its onset for AM times ("dawn"). The resulting phase shifts from the six SLDs were similar, permitting their combination into a single phase-response curve (PRC) of 1605 shifts. This SLD composite PRC rose at 10:15 PM, peaked at 2 AM (81 min advanced shift), fell linearly to 5:55 AM, and then abruptly to normal at 6 AM (no shift). Peak shift was unaffected by light pulse duration or intensity, or hamster age. The SLD composite PRC lacked the 6 PM-9 PM curve of delayed shifts present in reported PRCs from LD 12 h:12 h and DD. However, a two-pulse experiment showed that all light from 6 PM to L-off was needed to block (balance) the advancing action of a 5 min morning light pulse, thereby maintaining entrainment. A working hypothesis to explain daily entrainment and seasonal fertility in the golden hamster is illustrated. A nomenclature for labeling the phases of the hamster clock (circadian time) is proposed.

  2. Expression of alpha and beta subunit isoforms of Na,K-ATPase in the mouse inner ear and changes with mutations at the Wv or Sld loci.

    PubMed

    Schulte, B A; Steel, K P

    1994-07-01

    Mice homozygous for mutations at the viable dominant spotting (Wv) and Steel-dickie (Sld) loci exhibit a similar phenotype which includes deafness. The auditory dysfunction derives from failure of the stria vascularis to develop normally and to generate a high positive endocochlear potential (EP). Because strial function is driven by Na,K-ATPase its expression was investigated in inner ears of Wv/Wv and Sld/Sld mice and their wild-type littermates by immunostaining with antisera against four of the enzyme's subunit isoforms. Wild-type mice from two different genetic backgrounds showed an identical distribution of subunit isoforms among inner ear transport cells. Several epithelial cell types coexpressed the alpha 1 and beta 1 subunits. Vestibular dark cells showed no reactivity for beta 1 but expressed abundant beta 2, whereas, strial marginal cells stained strongly for both beta isoforms. The only qualitative difference between mutant and wild-type mice was the absence of beta 1 subunit in marginal cells of the mutant's stria. However, it is unlikely that this difference accounts for failure of mutants to generate a high EP because the beta 1 subunit is not present in the stria vascularis of either rats or gerbils with normal EP values. Strong immunostaining for Na,K-ATPase in lateral wall fibrocytes of normal mice along with diminished immunoreactivity in the mutants supports the concept that these strategically located transport fibrocytes actively resorb K+ leaked across Reissner's membrane into scala vestibuli or effluxed from hair cells and nerves into scala tympani. It is further speculated that the resorbed K+ normally is siphoned down its concentration gradient into the intrastrial space through gap junctions between fibrocytes and strial basal and intermediate cells where it is recycled back to endolymph via marginal cells. Thus, failure of mutants to generate a positive EP could be explained by the absence of intermediate cells which may form the final link in the conduit for moving K+ from perilymph to the intrastrial compartment.

  3. Multiple Correlation versus Multiple Regression.

    ERIC Educational Resources Information Center

    Huberty, Carl J.

    2003-01-01

    Describes differences between multiple correlation analysis (MCA) and multiple regression analysis (MRA), showing how these approaches involve different research questions and study designs, different inferential approaches, different analysis strategies, and different reported information. (SLD)

  4. Piracy without Penalty.

    ERIC Educational Resources Information Center

    Foster, Andrea L.

    2003-01-01

    Outlines the confusion arising when public colleges invoke a constitutional shield when they are accused of pirating software. Some state institutions claim immunity under the 11th Amendment from prosecution for infringement of intellectual property. (SLD)

  5. A Black Woman Superintendent Tells.

    ERIC Educational Resources Information Center

    Grogan, Margaret

    2000-01-01

    This poem is composed from the interview data of a participant in a qualitative study of what it means to be a woman superintendent. This representation captures the woman's rhythms, images, and metaphors. (SLD)

  6. Stakeholder Bias.

    ERIC Educational Resources Information Center

    House, Ernest R.

    2003-01-01

    Discusses the nature of stakeholder participation in evaluation and contrasts E. House's commitment to involving all stakeholders to ensure that interests of all are included with other theorists' preference to involve a few stakeholders more intensely. (SLD)

  7. Pricing and Enrollment Planning.

    ERIC Educational Resources Information Center

    Martin, Robert E.

    2003-01-01

    Presents a management model for pricing and enrollment planning that yields optimal pricing decisions relative to student fees and average scholarship, the institution's financial ability to support students, and an average cost-pricing rule. (SLD)

  8. Solving Infeasibility Problems in Computerized Test Assembly.

    ERIC Educational Resources Information Center

    Timminga, Ellen

    1998-01-01

    Discusses problems of diagnosing and repairing infeasible linear-programming models in computerized test assembly. Demonstrates that it is possible to localize the causes of infeasibility, although this is not always easy. (SLD)

  9. The Social Psychology of Creativity.

    ERIC Educational Resources Information Center

    Hennessey, Beth A.

    2003-01-01

    Outlines investigations revealing that the typical classroom is filled with teaching practices that kill intrinsic motivation and creativity. Reviews research designed to immunize students against the negative effects of these damaging classroom elements. (SLD)

  10. Implementing Performance Assessment in the Classroom.

    ERIC Educational Resources Information Center

    Brualdi, Amy

    1999-01-01

    Provides advice on implementing performance assessment in the classroom. Outlines the basic steps from defining the purpose of the assessment to giving the student feedback. Advice is also given about scoring rubrics. (SLD)

  11. Multimedia Learning: Beyond Modality. Commentary.

    ERIC Educational Resources Information Center

    Reimann, P.

    2003-01-01

    Identifies and summarizes instructional messages in the articles in this theme issue and also identifies central theoretical issues, focusing on: (1) external representations; (2) dual coding theory; and (3) the effects of animations on learning. (SLD)

  12. Jensen, Jensenism, and the Sociology of Intelligence.

    ERIC Educational Resources Information Center

    Gottfredson, Linda S.

    1998-01-01

    Describes public controversy over Jensen's work on genetic differences in intelligence as an example of sociopolitical consequences that can accompany the dispersion in "g" (general factor of intelligence) in a society. (Author/SLD)

  13. Three-Mode Models and Individual Differences in Semantic Differential Data.

    ERIC Educational Resources Information Center

    Murakami, Takashi; Kroonenberg, Pieter M.

    2003-01-01

    Demonstrated how individual differences in semantic differential data can be modeled and assessed using three-mode models by studying the characterization of Chopin's "Preludes" by 38 Japanese college students. (SLD)

  14. Greening the World or "Greenwashing" a Reputation?

    ERIC Educational Resources Information Center

    Blumenstyk, Goldie

    2003-01-01

    Describes the role of Exxon Mobil in the new Global Climate and Energy Project at Stanford University. Questions about the university's independence from the corporation and real impact on the environment are explored. (SLD)

  15. Opinions on Current Reading.

    ERIC Educational Resources Information Center

    Journal of Blacks in Higher Education, 1997

    1997-01-01

    Presents eight reviews of current books, covering issues of particular interest to black educators and historians. Topics considered include slavery, college admissions and affirmative action, the marginalization of black scientists, black politics, bigotry, and higher education. (SLD)

  16. Evaluating Informal Support.

    ERIC Educational Resources Information Center

    Litwin, Howard; Auslander, Gail K.

    1990-01-01

    Dilemmas inherent in the attempt to measure and evaluate informal supports available to individuals in need of social care are illustrated through a study of 400 elderly persons in Jerusalem. Practical guidelines for evaluation are presented. (SLD)

  17. Symbiotic Research: A Case for Ethical Scholarship.

    ERIC Educational Resources Information Center

    Carey, David, Jr.

    2003-01-01

    Describes the experiences of a teacher researcher on a Fulbright fellowship in Guatemala in the development of local historical projects and the involvement of local people in the research behind the historical projects. (SLD)

  18. The Jackie Robinson I Remember.

    ERIC Educational Resources Information Center

    Kahn, Roger

    1997-01-01

    This memoir describes Jackie Robinson's historic career as the first black player in major league baseball, emphasizing his courage and determination in the face of racism, and recounting the background to his entry into baseball. (SLD)

  19. Computerized Adaptive Testing: Overview and Introduction.

    ERIC Educational Resources Information Center

    Meijer, Rob R.; Nering, Michael L.

    1999-01-01

    Provides an overview of computerized adaptive testing (CAT) and introduces contributions to this special issue. CAT elements discussed include item selection, estimation of the latent trait, item exposure, measurement precision, and item-bank development. (SLD)

  20. Doing Gender in Management Education.

    ERIC Educational Resources Information Center

    Marshall, Judi

    1999-01-01

    Explores teaching gender to management students, mainly those working toward Masters in Business Administration degrees. Introduces a gender awareness approach and illustrates it with two examples of "doing" gender using multiple associations of that term. (SLD)

  1. A vertex detector for SLD

    NASA Astrophysics Data System (ADS)

    Damerell, C. J. S.; English, R. L.; Gillman, A. R.; Lintern, A. L.; Phillips, D.; Rong, G.; Sutton, C.; Wickens, F. J.; Agnew, G.; Clarke, P.; Hedges, S.; Watts, S. J.

    1989-03-01

    The SLAC Linear Collider is currently being commissioned. A second-generation detector for SLC, known as SLD, is now under construction. In the centre of this 4000 ton detector there will be a vertex detector (VXD) consisting of 4 barrels of 2-dimensional CCDs, approximately 250 CCDs in total. This detector will be used as a tracking microscope, able to pinpoint the outgoing tracks with a precision of about 5 μm, and thus to distinguish between particles produced at the primary vertex and those which result from the decay of heavy-flavour quarks (charm, bottom and possibly others) or from the decay of heavy leptons. This paper describes the present state of the VXD project, with particular emphasis on the signal processing procedures which will reduce the 60 million measurements of pixel contents for each event to a manageable level (some tens of kilobytes).

  2. Tailor-made dimensions of diblock copolymer truncated micelles on a solid by UV irradiation.

    PubMed

    Liou, Jiun-You; Sun, Ya-Sen

    2015-09-28

    We investigated the structural evolution of truncated micelles in ultrathin films of polystyrene-block-poly(2-vinylpyridine), PS-b-P2VP, of monolayer thickness on bare silicon substrates (SiOx/Si) upon UV irradiation in air- (UVIA) and nitrogen-rich (UVIN) environments. The structural evolution of micelles upon UV irradiation was monitored using GISAXS measurements in situ, while the surface morphology was probed using atomic force microscopy ex situ and the chemical composition using X-ray photoelectron spectroscopy (XPS). This work provides clear evidence for the interpretation of the relationship between the structural evolution and photochemical reactions in PS-b-P2VP truncated micelles upon UVIA and UVIN. Under UVIA treatment, photolysis and cross-linking reactions coexisted within the micelles; photolysis occurred mainly at the top of the micelles, whereas cross-linking occurred preferentially at the bottom. The shape and size of UVIA-treated truncated micelles were controlled predominantly by oxidative photolysis reactions, which depended on the concentration gradient of free radicals and oxygen along the micelle height. Because of an interplay between photolysis and photo-crosslinking, the scattering length densities (SLD) of PS and P2VP remained constant. In contrast, UVIN treatments enhanced the contrast in SLD between the PS shell and the P2VP core as cross-linking dominated over photolysis in the presence of nitrogen. The enhancement of the SLD contrast was due to the various degrees of cross-linking under UVIN for the PS and P2VP blocks.

  3. Se(VI) Reduction and the Precipitation of Se(0) Precipitation by the Facultative Bacterium Enterobacter Cloacae SLD1a-1 is Regulated by FNR

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yee,N.; Ma, J.; Dalia, A.

    2007-01-01

    The fate of selenium in the environment is controlled, in part, by microbial selenium oxyanion reduction and Se(0) precipitation. In this study, we identified a genetic regulator that controls selenate reductase activity in the Se-reducing bacterium Enterobacter cloacae SLD1a-1. Heterologous expression of the global anaerobic regulatory gene fnr (fumarate nitrate reduction regulator) from E. cloacae in the non-Se-reducing strain Escherichia coli S17-1 activated the ability to reduce Se(VI) and precipitate insoluble Se(0) particles. Se(VI) reduction by E. coli S17-1 containing the fnr gene occurred at rates similar to those for E. cloacae, with first-order reaction constants of k = 2.07more » x 10{sup -2} h{sup -1} and k = 3.36 x 10{sup -2} h{sup -1}, respectively, and produced elemental selenium particles with identical morphologies and short-range atomic orders. Mutation of the fnr gene in E. cloacae SLD1a-1 resulted in derivative strains that were deficient in selenate reductase activity and unable to precipitate elemental selenium. Complementation by the wild-type fnr sequence restored the ability of mutant strains to reduce Se(VI). Our findings suggest that Se(VI) reduction and the precipitation of Se(0) by facultative anaerobes are regulated by oxygen-sensing transcription factors and occur under suboxic conditions.« less

  4. Going the Distance.

    ERIC Educational Resources Information Center

    Leno, Arthur J.

    2003-01-01

    Describes the development and implementation of the distance education program at Peirce College. This Internet-mediated distance learning program focuses on practical fields of study, drawing on the college's strengths in business administration, information technology, and paralegal studies. (SLD)

  5. Did You Hear the One about the Professor?

    ERIC Educational Resources Information Center

    Bartlett, Thomas

    2003-01-01

    Describes the ways in which a professor of statistics uses humor in the classroom. Ronald A. Berk uses humor as systematic teaching tool even though some other faculty and administrators consider his approach frivolous. (SLD)

  6. Does Attention Serve to Integrate Features?

    ERIC Educational Resources Information Center

    Navon, David; Treisman, Anne

    1990-01-01

    An article and two commentaries consider the attentional feature-integration theory proposed by A. Treisman and colleagues. Hypotheses about the encoding of conjunctions are reviewed. Whether or not data support perceptual feature-integration is argued. (SLD)

  7. Reasons for Hierarchical Linear Modeling: A Reminder.

    ERIC Educational Resources Information Center

    Wang, Jianjun

    1999-01-01

    Uses examples of hierarchical linear modeling (HLM) at local and national levels to illustrate proper applications of HLM and dummy variable regression. Raises cautions about the circumstances under which hierarchical data do not need HLM. (SLD)

  8. The Ethical Use of Evidence in Biomedicine.

    ERIC Educational Resources Information Center

    Pellegrino, Edmund D.

    1999-01-01

    Examines the ethics of data collection and dissemination, suggesting criteria for the morally responsible treatment of evidence collection, dissemination, and use. Comments on the importance of V. Mike's proposal of an "ethics of evidence." (SLD)

  9. Realizations of Measurement.

    ERIC Educational Resources Information Center

    Wright, Benjamin D.

    2000-01-01

    Uses the analogy of squeezing two glasses of orange juice from 4 pounds of oranges, no matter how many oranges constitute 4 pounds, to illustrate the distinction between art and science, as between counting right answers and constructing measures. (SLD)

  10. The Johns Hopkins Address Registration System (JHARS): Anatomy of an Application.

    ERIC Educational Resources Information Center

    Cyzyk, Mark

    2003-01-01

    Describes the registration system at Johns Hopkins University, Maryland, which allows centralized administration and self-signup for access to the Hopkins network. Reception of the system has been overwhelmingly positive. (SLD)

  11. Roadway data representation and application development : final report, December 2009.

    DOT National Transportation Integrated Search

    2009-08-06

    The Straight-line Diagrammer, a web-based application to produce Straight-line Diagrams (SLDs) automatically, was developed in this project to replace old application (AutoSLD) which has outdated structure and limited capabilities.

  12. Negligible Sex Differences in General Intelligence.

    ERIC Educational Resources Information Center

    Colom, Roberto; Juan-Espinosa, Manuel; Abad, Francisco; Garcia, Luis F.

    2000-01-01

    Studied sex differences in general intelligence in 10,475 adults taking cognitive test batteries. Results suggest a negligible difference in general intelligence, a finding consistent with findings from quite different test batteries and subject samples. (SLD)

  13. Giving Voice to Low-Income Noncustodial Fathers.

    ERIC Educational Resources Information Center

    Ferguson, Alan K.

    2000-01-01

    Describes the Fatherhood Responsibility Program of the Urban League of Greater Madison Wisconsin and explores its relevance for the learning context, process, process, and experience as they relate to noncustodial fathers in fatherhood programs. (SLD)

  14. The Road to Reason.

    ERIC Educational Resources Information Center

    Wright, Benjamin D.

    2000-01-01

    Summarizes the distinctions between qualitative and quantitative research and shows their complementary aspects. Shows there is no contradiction or conflict between the qualitative and the quantitative and discusses Rasch measurement as the construction tool of quantitative research. (SLD)

  15. Mitigating Security Issues: The University of Memphis Case.

    ERIC Educational Resources Information Center

    Jackson, Robert; Frolick, Mark N.

    2003-01-01

    Studied a server security breach at the University of Memphis, Tennessee, to highlight personnel roles, detection of the compromised server, policy enforcement, forensics, and the proactive search for other servers threatened in the same way. (SLD)

  16. Interpreting Research on School Resources and Student Achievement: A Rejoinder to Hanushek.

    ERIC Educational Resources Information Center

    Greenwald, Rob; Hedges, Larry V.; Laine, Richard

    1996-01-01

    Supports the findings of a meta-analysis that demonstrates that student achievement is related to the availability of resources, disagreeing with criticisms of method and sample selection made by E. Hanushek (1996). (SLD)

  17. Influential Observations in Principal Factor Analysis.

    ERIC Educational Resources Information Center

    Tanaka, Yutaka; Odaka, Yoshimasa

    1989-01-01

    A method is proposed for detecting influential observations in iterative principal factor analysis. Theoretical influence functions are derived for two components of the common variance decomposition. The major mathematical tool is the influence function derived by Tanaka (1988). (SLD)

  18. Women in Academia: Work-Related Stresses.

    ERIC Educational Resources Information Center

    Keim, Jeanmarie; Erickson, Chris

    1998-01-01

    Highlights some of the more common stressors and difficulties faced by women in academia, particularly those of junior rank, in the areas of teaching, scholarship, and service, and outlines effective strategies, including plans for institutions, for overcoming barriers. (SLD)

  19. Controlled Fission: Teaching Supercharged Subjects.

    ERIC Educational Resources Information Center

    Pace, David

    2003-01-01

    Shaping classroom experiences before controversial material is encountered in a class increases the likelihood that students will maintain higher mental function while examining that material. Presents 10 strategies for planning a course that facilitates quality discussion and thoughtful debate. (SLD)

  20. Exploring the Replicability of a Study's Results: Bootstrap Statistics for the Multivariate Case.

    ERIC Educational Resources Information Center

    Thompson, Bruce

    1995-01-01

    Use of the bootstrap method in a canonical correlation analysis to evaluate the replicability of a study's results is illustrated. More confidence may be vested in research results that replicate. (SLD)

  1. Mental Health, Social Context, Refugees and Immigrants: A Cultural Interface.

    ERIC Educational Resources Information Center

    Mayadas, Nazneen S.; Ramanathan, Chathapuram S.; Suarez, Zulema

    1999-01-01

    Explores how the lack of awareness of human diversity can adversely affect the mental health care of nondominant ethnic groups. Proposes a three-dimensional cultural-interface model for assessing and treating mental health problems. (SLD)

  2. Classification of Instructional Programs: 2000 Edition.

    ERIC Educational Resources Information Center

    Education Statistics Quarterly, 2002

    2002-01-01

    Describes the methods, processes, and procedures used to develop the Classification of Instructional Programs 2000 (CIP:2000), the National Center for Education Statistics taxonomy of instructional programs, and provides information on the CIP's structure, contents, and organization. (SLD)

  3. The "Sisters and the Bro'."

    ERIC Educational Resources Information Center

    Foreman, Allison

    2002-01-01

    Describes the administrative team Dr. Johnetta Cole has assembled at Bennett College, one of the only two historically black colleges for women in the United States. Bennett, which has faced many difficulties in recent years, appears poised to rebound. (SLD)

  4. Ceremonial Access.

    ERIC Educational Resources Information Center

    Singer, Eliot

    1998-01-01

    Explores the use of elements of the cultural practices of native peoples in the elementary school classroom as a way of introducing children to other cultures. Discusses the appropriate use of native-like experiences in contextualized mimesis to bring life to curricula. (SLD)

  5. Contracting Maintenance Services: An Easy Question, but a Difficult Answer.

    ERIC Educational Resources Information Center

    Geiger, Philip E.

    2003-01-01

    Discusses issues involved in outsourcing school maintenance and custodial services. There are many advantages to this approach, but it has definite drawbacks. In many instances, a combination of contract and employee services works well. (SLD)

  6. Beyond Principal Component Analysis: A Trilinear Decomposition Model and Least Squares Estimation.

    ERIC Educational Resources Information Center

    Pham, Tuan Dinh; Mocks, Joachim

    1992-01-01

    Sufficient conditions are derived for the consistency and asymptotic normality of the least squares estimator of a trilinear decomposition model for multiway data analysis. The limiting covariance matrix is computed. (Author/SLD)

  7. Evaluation and Research for Technology: Not Just Playing Around.

    ERIC Educational Resources Information Center

    Baker, Eva L.; O'Neil, Harold F., Jr.

    2003-01-01

    Discusses some of the challenges of technology-based training and education, the role of quality verification and evaluation, and strategies to integrate evaluation into the everyday design of technology-based systems for education and training. (SLD)

  8. FAA Perspective

    NASA Technical Reports Server (NTRS)

    Bond, Tom

    2009-01-01

    This viewgraph presentation describes the Federal Aviation Administration's perspective on improvements on aircraft icing. The most important areas that are discussed include: 1) Improvements in SLD engineering tools to meet concerns about means of compliance (MOC); and 2) 3-D iced aerodynamics.

  9. Estimating Local Child Abuse.

    ERIC Educational Resources Information Center

    Ards, Sheila

    1989-01-01

    Three conceptual approaches to estimating local child abuse rates using the National Incidence Study of Child Abuse and Neglect data set are evaluated. All three approaches yield estimates of actual abuse cases that exceed the number of reported cases. (SLD)

  10. Fetterman-House: A Process Use Distinction and a Theory.

    ERIC Educational Resources Information Center

    Fetterman, David

    2003-01-01

    Discusses the concept of process use as an important distinction between the evaluation theories of E. House and D. Fetterman, thus helping to explain the discordant results of C. Christie for these two theories. (SLD)

  11. Youth and Evaluation: Empowered Social-Change Agents.

    ERIC Educational Resources Information Center

    Fetterman, David

    2003-01-01

    Summarizes the chapters of this theme issue on youth participatory evaluation. The overarching theme from this collection is the shift from a focus on youth as defective to a view of youth as assets in community development. (SLD)

  12. Understanding and Developing Controversial Issues in College Courses.

    ERIC Educational Resources Information Center

    Payne, Brian K.; Gainey, Randy R.

    2003-01-01

    Discusses common controversial issues in different college disciplines, such as the death penalty and drug legalization. Also suggests useful methods for encouraging enlightening discussions, such as verbal and physical cues, student-centered activities, and text selection. (SLD)

  13. Language and pragmatic functions in school-age children on the autism spectrum.

    PubMed

    Ramberg, C; Ehlers, S; Nydén, A; Johansson, M; Gillberg, C

    1996-01-01

    This study examined group differences in language and pragmatic functions across sex-, age- and IQ-matched samples of Asperger syndrome (N = 22), high-functioning autism (N = 11), deficits in attention, motor control and perception (DAMP) (N = 11), and speech and language disorder (SLD) (N = 11) groups. The purpose was to explore possible differentiating features in the fields of vocabulary, comprehension and pragmatics and, in addition, to determine whether Asperger syndrome could be reliably separated from high-functioning autism on these variables. The findings suggest that Asperger syndrome may be associated with higher full-scale and verbal IQ than high-functioning autism; Asperger syndrome may not be associated with better pragmatic skills (as defined in this context) than high-functioning autism; language comprehension may not clearly separate Asperger syndrome and high-functioning autism once the effects of very low IQ are partialled out; both DAMP and SLD can be distinctly separated from Asperger syndrome and autism.

  14. Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins

    PubMed Central

    Yeeles, Joseph T.P.; Deegan, Tom D.; Janska, Agnieszka; Early, Anne; Diffley, John F. X.

    2016-01-01

    Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle. To accomplish this, initiation is partitioned into two temporally discrete steps: a double hexameric MCM complex is first loaded at replication origins during G1 phase, and then converted to the active CMG (Cdc45, MCM, GINS) helicase during S phase. Here we describe the reconstitution of budding yeast DNA replication initiation with 16 purified replication factors, made from 42 polypeptides. Origin-dependent initiation recapitulates regulation seen in vivo. Cyclin dependent kinase (CDK) inhibits MCM loading by phosphorylating the origin recognition complex (ORC) and promotes CMG formation by phosphorylating Sld2 and Sld3. Dbf4 dependent kinase (DDK) promotes replication by phosphorylating MCM, and can act either before or after CDK. These experiments define the minimum complement of proteins, protein kinase substrates and co-factors required for regulated eukaryotic DNA replication. PMID:25739503

  15. Regulated eukaryotic DNA replication origin firing with purified proteins.

    PubMed

    Yeeles, Joseph T P; Deegan, Tom D; Janska, Agnieszka; Early, Anne; Diffley, John F X

    2015-03-26

    Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle. To accomplish this, initiation is partitioned into two temporally discrete steps: a double hexameric minichromosome maintenance (MCM) complex is first loaded at replication origins during G1 phase, and then converted to the active CMG (Cdc45-MCM-GINS) helicase during S phase. Here we describe the reconstitution of budding yeast DNA replication initiation with 16 purified replication factors, made from 42 polypeptides. Origin-dependent initiation recapitulates regulation seen in vivo. Cyclin-dependent kinase (CDK) inhibits MCM loading by phosphorylating the origin recognition complex (ORC) and promotes CMG formation by phosphorylating Sld2 and Sld3. Dbf4-dependent kinase (DDK) promotes replication by phosphorylating MCM, and can act either before or after CDK. These experiments define the minimum complement of proteins, protein kinase substrates and co-factors required for regulated eukaryotic DNA replication.

  16. Comparison of Aircraft Icing Growth Assessment Software

    NASA Technical Reports Server (NTRS)

    Wright, William; Potapczuk, Mark G.; Levinson, Laurie H.

    2011-01-01

    A research project is underway to produce computer software that can accurately predict ice growth under any meteorological conditions for any aircraft surface. An extensive comparison of the results in a quantifiable manner against the database of ice shapes that have been generated in the NASA Glenn Icing Research Tunnel (IRT) has been performed, including additional data taken to extend the database in the Super-cooled Large Drop (SLD) regime. The project shows the differences in ice shape between LEWICE 3.2.2, GlennICE, and experimental data. The project addresses the validation of the software against a recent set of ice-shape data in the SLD regime. This validation effort mirrors a similar effort undertaken for previous validations of LEWICE. Those reports quantified the ice accretion prediction capabilities of the LEWICE software. Several ice geometry features were proposed for comparing ice shapes in a quantitative manner. The resulting analysis showed that LEWICE compared well to the available experimental data.

  17. IR-thermography for Quality Prediction in Selective Laser Deburring

    NASA Astrophysics Data System (ADS)

    Möller, Mauritz; Conrad, Christian; Haimerl, Walter; Emmelmann, Claus

    Selective Laser Deburring (SLD) is an innovative edge-refinement process being developed at the Laser Zentrum Nord (LZN) in Hamburg. It offers a wear-free processing of defined radii and bevels at the edges as well as the possibility to deburr several materials with the same laser source. Sheet metal parts of various applications need to be post-processed to remove sharp edges and burrs remaining from the initial production process. Thus, SLD will provide an extended degree of automation for the next generation of manufacturing facilities. This paper investigates the dependence between the deburring result and the temperature field in- and post-process. In order to achieve this, the surface temperature near to the deburred edge is monitored with IR-thermography. Different strategies are discussed for the approach using the IR-information as a quality assurance. Additional experiments are performed to rate the accuracy of the quality prediction method in different deburring applications.

  18. SLDAssay: A software package and web tool for analyzing limiting dilution assays.

    PubMed

    Trumble, Ilana M; Allmon, Andrew G; Archin, Nancie M; Rigdon, Joseph; Francis, Owen; Baldoni, Pedro L; Hudgens, Michael G

    2017-11-01

    Serial limiting dilution (SLD) assays are used in many areas of infectious disease related research. This paper presents SLDAssay, a free and publicly available R software package and web tool for analyzing data from SLD assays. SLDAssay computes the maximum likelihood estimate (MLE) for the concentration of target cells, with corresponding exact and asymptotic confidence intervals. Exact and asymptotic goodness of fit p-values, and a bias-corrected (BC) MLE are also provided. No other publicly available software currently implements the BC MLE or the exact methods. For validation of SLDAssay, results from Myers et al. (1994) are replicated. Simulations demonstrate the BC MLE is less biased than the MLE. Additionally, simulations demonstrate that exact methods tend to give better confidence interval coverage and goodness-of-fit tests with lower type I error than the asymptotic methods. Additional advantages of using exact methods are also discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Additional Study of Water Droplet Median Volume Diameter (MVD) Effects on Ice Shapes

    NASA Technical Reports Server (NTRS)

    Tsao, Jen-Ching; Anderson, David N.

    2005-01-01

    This paper reports the result of an experimental study in the NASA Glenn Icing Research Tunnel (IRT) to evaluate how well the MVD-independent effect identified previously might apply to SLD conditions in rime icing situations. Models were NACA 0012 wing sections with chords of 53.3 and 91.4 cm. Tests were conducted with a nominal airspeed of 77 m/s (150 kt) and a number of MVD's ranging from 15 to 100 m with LWC of 0.5 to 1 g/cu m. In the present study, ice shapes recorded from past studies and recent results at SLD and Appendix-C conditions are reviewed to show that droplet diameter is not important to rime ice shape for MVD of 30 microns or larger, but for less than 30 m drop sizes a rime ice shape transition from convex to wedge to spearhead type ice shape is observed.

  20. QCD tests with SLD and polarized beams

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Strauss, M.G.

    1994-12-01

    The author presents a measurement of the strong coupling {alpha}{sub s} derived from multijet rates using data collected by the SLD experiment at SLAC and find that {alpha}{sub s}(M{sub Z}{sup 2}) = 0.118 {+-} 0.002(stat.) {+-} 0.003(syst.) {+-} 0.010(theory). He presents tests of the flavor independence of strong interactions via preliminary measurements of the ratios {alpha}{sub s}(b)/{alpha}{sub s}(udsc) and {alpha}{sub s}(uds)/{alpha}{sub s}(bc). In addition, the group has measured the difference in charged particle multiplicity between Z{sup 0} {yields} b{bar b} and Z{sup 0} {yields} u{bar u}, d{bar d}, s{bar s} events, and find that it supports the prediction of perturbativemore » QCD that the multiplicity difference be independent of center-of-mass energy. Finally, the group has made a preliminary study of jet polarization using the jet handedness technique.« less

  1. STS-55 Pilot Henricks uses CTE equipment mounted on SL-D2 aft end cone

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Pilot Terence T. Henricks, positioned in front of an adjustable workstation mounted on the Spacelab Deutsche 2 (SL-D2) science module aft end cone, conducts Crew Telesupport Experiment (CTE). The STS-55 crew portrait (STS055(S)002) appears on the screen of the Macintosh portable computer. CTE will demonstrate real-time communication between the shuttle crew and the ground via a computer-based multimedia documentation file that includes text, graphics, and photos. CTE is expected to improve the effectiveness of on-orbit payload operations, returns from scientific investigations, crew interaction with the ground, and contingency maintenance tasks for systems and payloads. Also in the view and attached to the end cone are a fire extinguisher, a checklist, and an STS-37 extravehicular activity (EVA) photo of Mission Specialist (MS1) and Payload Commander (PLC) Jerry L. Ross (STS037-18-032).

  2. The impact of a spiritual legacy intervention in patients with brain cancers and other neurologic illnesses and their support persons.

    PubMed

    Piderman, Katherine M; Radecki Breitkopf, Carmen; Jenkins, Sarah M; Lapid, Maria I; Kwete, Gracia M; Sytsma, Terin T; Lovejoy, Laura A; Yoder, Timothy J; Jatoi, Aminah

    2017-03-01

    The objectives were to assess the feasibility of using a novel, comprehensive chaplain-led spiritual life review interview to develop a personal Spiritual Legacy Document (SLD) for persons with brain tumors and other neurodegenerative diseases and to describe spiritual well-being (SWB), spiritual coping, and quality of life (QOL) of patients and their support persons (SP) before and after receipt of the SLD. Patient-SP pairs were enrolled over a 2-year period. Assessments included the Functional Assessment of Chronic Illness Therapy-Spiritual Expanded Version, Brief Religious Coping Scale, Brief COPE Inventory, and QOL Linear Analog Scale. Baseline assessments were completed prior to an audio-recorded spiritual life review interview with a chaplain. Thirty-two patient/SP pairs were enrolled; 27 completed baseline assessments and the interview. Twenty-four reviewed their SLD and were eligible for follow-up. A total of 15 patients and 12 SPs completed the 1-month follow-up; 10 patients and seven SPs completed the 3-month follow-up. Patients endorsed high levels of SWB and spiritual coping at baseline. Both patients and SPs evidenced improvement on several aspects of SWB, spiritual coping, and QOL at 1 month, but patients' decreased financial well-being was also observed. Patients and SPs demonstrated favorable changes in peacefulness and positive religious coping at both time points. A chaplain-led spiritual life review is a feasible intervention for patients with neurodegenerative disease and results in beneficial effects on patients and SPs. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  3. Impact of sleep deprivation on anaesthesia residents' non-technical skills: a pilot simulation-based prospective randomized trial.

    PubMed

    Neuschwander, A; Job, A; Younes, A; Mignon, A; Delgoulet, C; Cabon, P; Mantz, J; Tesniere, A

    2017-07-01

    Sleep deprivation is common in anaesthesia residents, but its impact on performance remains uncertain. Non-technical skills (team working, situation awareness, decision making, and task management) are key components of quality of care in anaesthesia, particularly in crisis situations occurring in the operating room. The impact of sleep deprivation on non-technical skills is unknown. We tested the hypothesis that in anaesthesia residents sleep deprivation is associated with impaired non-technical skills. Twenty anaesthesia residents were randomly allocated to undergo a simulation session after a night shift [sleep-deprived (SLD) group, n =10] or after a night of rest [rested (R) group, n =10] from January to March 2015. The simulated scenario was a situation of crisis management in the operating room. The primary end point was a composite score of anaesthetists' non-technical skills (ANTS) assessed by two blinded evaluators. Non-technical skills were significantly impaired in the SLD group [ANTS score 12.2 (interquartile range 10.5-13)] compared with the R group [14.5 (14-15), P <0.02]. This difference was mainly accounted for by a difference in the team working item. On the day of simulation, the SLD group showed increased sleepiness and decreased confidence in anaesthesia skills. In this randomized pilot trial, sleep deprivation was associated with impaired non-technical skills of anaesthesia residents in a simulated anaesthesia intraoperative crisis scenario. NCT02622217. © The Author 2017. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  4. Expressive map design: OGC SLD/SE++ extension for expressive map styles

    NASA Astrophysics Data System (ADS)

    Christophe, Sidonie; Duménieu, Bertrand; Masse, Antoine; Hoarau, Charlotte; Ory, Jérémie; Brédif, Mathieu; Lecordix, François; Mellado, Nicolas; Turbet, Jérémie; Loi, Hugo; Hurtut, Thomas; Vanderhaeghe, David; Vergne, Romain; Thollot, Joëlle

    2018-05-01

    In the context of custom map design, handling more artistic and expressive tools has been identified as a carto-graphic need, in order to design stylized and expressive maps. Based on previous works on style formalization, an approach for specifying the map style has been proposed and experimented for particular use cases. A first step deals with the analysis of inspiration sources, in order to extract `what does make the style of the source', i.e. the salient visual characteristics to be automatically reproduced (textures, spatial arrangements, linear stylization, etc.). In a second step, in order to mimic and generate those visual characteristics, existing and innovative rendering techniques have been implemented in our GIS engine, thus extending the capabilities to generate expressive renderings. Therefore, an extension of the existing cartographic pipeline has been proposed based on the following aspects: 1- extension of the symbolization specifications OGC SLD/SE in order to provide a formalism to specify and reference expressive rendering methods; 2- separate the specification of each rendering method and its parameterization, as metadata. The main contribution has been described in (Christophe et al. 2016). In this paper, we focus firstly on the extension of the cartographic pipeline (SLD++ and metadata) and secondly on map design capabilities which have been experimented on various topographic styles: old cartographic styles (Cassini), artistic styles (watercolor, impressionism, Japanese print), hybrid topographic styles (ortho-imagery & vector data) and finally abstract and photo-realist styles for the geovisualization of costal area. The genericity and interoperability of our approach are promising and have already been tested for 3D visualization.

  5. Relationships between Eye Movements during Sentence Reading Comprehension, Word Spelling and Reading, and DTI and fmri Connectivity In Students with and without Dysgraphia or Dyslexia

    PubMed Central

    Yagle, Kevin; Richards, Todd; Askren, Katie; Mestre, Zoe; Beers, Scott; Abbott, Robert; Nagy, William; Boord, Peter; Berninger, Virginia

    2017-01-01

    While eye movements were recorded and brains scanned, 29 children with and without specific learning disabilities (SLDs) decided if sentences they read (half with only correctly spelled words and half with homonym foils) were meaningful. Significant main effects were found for diagnostic groups (non-SLD control, dysgraphia control, and dyslexia) in total fixation (dwell) time, total number of fixations, and total regressions in during saccades; the dyslexia group had longer and more fixations and made more regressions in during saccades than either control group. The dyslexia group also differed from both control groups in (a) fractional anisotropy in left optic radiation and (b) silent word reading fluency on a task in which surrounding letters can be distracting, consistent with Rayner's selective attention dyslexia model. Different profiles for non-SLD control, dysgraphia, and dyslexia groups were identified in correlations between total fixation time, total number of fixations, regressions in during saccades, magnitude of gray matter connectivity during the fMRI sentence reading comprehension from left occipital temporal cortex seed with right BA44 and from left inferior frontal gyrus with right inferior frontoccipital fasciculus, and normed word-specific spelling and silent word reading fluency measures. The dysgraphia group was more likely than the non-SLD control or dyslexia groups to show negative correlations between eye movement outcomes and sentences containing incorrect homonym foils. Findings are discussed in reference to a systems approach in future sentence reading comprehension research that integrates eye movement, brain, and literacy measures. PMID:28936361

  6. Relationships between Eye Movements during Sentence Reading Comprehension, Word Spelling and Reading, and DTI and fmri Connectivity In Students with and without Dysgraphia or Dyslexia.

    PubMed

    Yagle, Kevin; Richards, Todd; Askren, Katie; Mestre, Zoe; Beers, Scott; Abbott, Robert; Nagy, William; Boord, Peter; Berninger, Virginia

    2017-01-01

    While eye movements were recorded and brains scanned, 29 children with and without specific learning disabilities (SLDs) decided if sentences they read (half with only correctly spelled words and half with homonym foils) were meaningful. Significant main effects were found for diagnostic groups (non-SLD control, dysgraphia control, and dyslexia) in total fixation (dwell) time, total number of fixations, and total regressions in during saccades; the dyslexia group had longer and more fixations and made more regressions in during saccades than either control group. The dyslexia group also differed from both control groups in (a) fractional anisotropy in left optic radiation and (b) silent word reading fluency on a task in which surrounding letters can be distracting, consistent with Rayner's selective attention dyslexia model. Different profiles for non-SLD control, dysgraphia, and dyslexia groups were identified in correlations between total fixation time, total number of fixations, regressions in during saccades, magnitude of gray matter connectivity during the fMRI sentence reading comprehension from left occipital temporal cortex seed with right BA44 and from left inferior frontal gyrus with right inferior frontoccipital fasciculus, and normed word-specific spelling and silent word reading fluency measures. The dysgraphia group was more likely than the non-SLD control or dyslexia groups to show negative correlations between eye movement outcomes and sentences containing incorrect homonym foils. Findings are discussed in reference to a systems approach in future sentence reading comprehension research that integrates eye movement, brain, and literacy measures.

  7. Casing Out Evaluation: Expanding Student Interest in Program Evaluation through Case Competitions.

    ERIC Educational Resources Information Center

    Obrecht, Michael; Porteous, Nancy; Haddock, Blair

    1998-01-01

    Describes the authors' experiences in organizing bilingual evaluation case competitions for the National Capital Chapter of the Canadian Evaluation Society for three years. Competition structure, eligibility, judging, contestant recruiting, and preparing cases are outlined. (SLD)

  8. Reducing Poverty, Not Inequality.

    ERIC Educational Resources Information Center

    Feldstein, Martin

    1999-01-01

    Public policy should not focus on reducing inequality, but rather on reducing poverty. Explores three possible sources of poverty: unemployment, a lack of earnings ability, and individual choice. Discusses the role of education in relation to the lack of ability to earn. (SLD)

  9. Application of the Bootstrap Methods in Factor Analysis.

    ERIC Educational Resources Information Center

    Ichikawa, Masanori; Konishi, Sadanori

    1995-01-01

    A Monte Carlo experiment was conducted to investigate the performance of bootstrap methods in normal theory maximum likelihood factor analysis when the distributional assumption was satisfied or unsatisfied. Problems arising with the use of bootstrap methods are highlighted. (SLD)

  10. IT: What's It Worth?

    ERIC Educational Resources Information Center

    Goldstein, Philip; Olson, Mark; Katz, Richard N.

    2003-01-01

    A 2-day meeting of EDUCAUSE and the National Association of College and University Business Officers explored the value of information technology (IT) for higher education. Presents the major conclusions reached by forum attendees and suggests a direction for future discussion. (SLD)

  11. Green Schools That Don't Cost Too Much.

    ERIC Educational Resources Information Center

    Fickes, Michael

    2003-01-01

    Describes the U.S. Green Building Council program, Leadership in Environmental and Energy Design, that has helped school districts around the country apply comprehensive environmental techniques to the design of 34 K-12 school buildings since 1999. (SLD)

  12. Design Specification Issues in Time-Series Intervention Models.

    ERIC Educational Resources Information Center

    Huitema, Bradley E.; McKean, Joseph W.

    2000-01-01

    Presents examples of egregious errors of interpretation in time-series intervention models and makes recommendations regarding the correct specification of the design matrix. Discusses the profound effects of variants of the slope change variable in the design matrix. (SLD)

  13. Innovative Methods: Resources for Research, Publishing, and Teaching.

    ERIC Educational Resources Information Center

    Gergen, Mary; Chrisler, Joan C.; LoCicero, Alice

    1999-01-01

    Reviews a selection of innovative methods congenial to research in feminist psychology and describes undergraduate and graduate courses that emphasize these methods in their curricula. Contains a bibliography of over 300 entries organized by type of innovative method. (SLD)

  14. Designing Measurement Studies under Budget Constraints: Controlling Error of Measurement and Power.

    ERIC Educational Resources Information Center

    Marcoulides, George A.

    1995-01-01

    A methodology is presented for minimizing the mean error variance-covariance component in studies with resource constraints. The method is illustrated using a one-facet multivariate design. Extensions to other designs are discussed. (SLD)

  15. Revenues and Expenditures for Public Elementary and Secondary Education: School Year 1999-2000.

    ERIC Educational Resources Information Center

    Johnson, Frank

    2002-01-01

    Presents national and state information on public education finances, including revenues by source, expenditures per student, and expenditures for instruction. Data are from the Common Core of Data (National Center for Education Statistics). (SLD)

  16. Revisioning the Process: A Case Study in Feminist Program Evaluation.

    ERIC Educational Resources Information Center

    Beardsley, Rebecca M.; Miller, Michelle Hughes

    2002-01-01

    Conducted a case study of the evaluation of a women's substance abuse prevention program and identified three key aspects of negotiated evaluation. Discusses the processes involved in feminist evaluation, including collaborative agenda setting and cooperative teamwork. (SLD)

  17. Mapping Variables.

    ERIC Educational Resources Information Center

    Stone, Mark H.; Wright, Benjamin D.; Stenner, A. Jackson

    1999-01-01

    Describes mapping variables, the principal technique for planning and constructing a test or rating instrument. A variable map is also useful for interpreting results. Provides several maps to show the importance and value of mapping a variable by person and item data. (Author/SLD)

  18. Determining Sample Size for Accurate Estimation of the Squared Multiple Correlation Coefficient.

    ERIC Educational Resources Information Center

    Algina, James; Olejnik, Stephen

    2000-01-01

    Discusses determining sample size for estimation of the squared multiple correlation coefficient and presents regression equations that permit determination of the sample size for estimating this parameter for up to 20 predictor variables. (SLD)

  19. Guidelines for Inspecting Your Roof Systems.

    ERIC Educational Resources Information Center

    Watkins, Daniel L.

    2003-01-01

    Provides guidelines for inspecting the roof of a facility. Suggests that periodic roof inspections should be performed on a quarterly or semi-annual basis and after severe storms. Proactively identifying potential problem areas is the best defense against roof leaks. (SLD)

  20. Advancing Democratic Leadership through Critical Theory.

    ERIC Educational Resources Information Center

    Lees, Kimberly A.

    1995-01-01

    Examines how the concepts advanced by critical theorists exemplify democratic leadership. The concept of democratic leadership is explored as a moral imperative of human issues, and the implications of leadership behavior that emulate the principles of democracy are discussed. (SLD)

  1. Selective Influence through Conditional Independence.

    ERIC Educational Resources Information Center

    Dzhafarov, Ehtibar N.

    2003-01-01

    Presents a generalization and improvement for the definition proposed by E. Dzhafarov (2001) for selectiveness in the dependence of several random variables on several (sets of) external factors. This generalization links the notion of selective influence with that of conditional independence. (SLD)

  2. Situated Literacies at Work.

    ERIC Educational Resources Information Center

    Searle, Jean

    2002-01-01

    Gathered data about work practices related to three motels and two eco-tourism sites. Findings suggest that actual workplace practices involve socially constructed literacies depending on the user's ability to make judgments on using the text or obtaining information from the text. (SLD)

  3. Invisible No More.

    ERIC Educational Resources Information Center

    King, Claire

    1999-01-01

    Describes the Romani (Gypsy) culture and refutes some stereotypes about this ethnic group. Discusses ways to improve educational opportunities for Romani children, whose culture has been wary of conventional public education and describes the importance of the Internet for Romani-American communication. (SLD)

  4. Women in Managerial Positions in Greek Education.

    ERIC Educational Resources Information Center

    Athanassoula-Reppa, Anastasia; Koutouzis, Manolis

    2002-01-01

    Discusses the under representation of women in managerial positions in Greece and the evidence of barriers that inhibit women from pursuing and taking such positions, a type of covert discrimination that is counter to notions of democratic citizenship. (SLD)

  5. Education-Community Partnerships: Who Uses Whom for What Purposes?

    ERIC Educational Resources Information Center

    Tyler, Jean B.; Haberman, Martin

    2002-01-01

    Examined education-community partnerships from the viewpoint of the community partners. Analyses based on three education-community partnerships, two successful and one failed, show the importance of understanding motivations and expectations. Describes lessons learned through such partnerships. (SLD)

  6. Neuropsychological Contributions to Theories of Part/Whole Organization.

    ERIC Educational Resources Information Center

    Robertson, Lynn C.; Lamb, Marvin R.

    1991-01-01

    It is proposed that there is a modular but interconnected system underlying the perceived hierarchical organization of objects. The discussion centers on neural and cognitive mechanisms of organizing objects within objects in at least four separate subsystems. (SLD)

  7. Ethical Challenges in Evaluation with Communities: A Manager's Perspective.

    ERIC Educational Resources Information Center

    Nee, David; Mojica, Maria I.

    1999-01-01

    Senior staff members at a family foundation share their perspectives, as managers and practitioners, on the ethical challenges and opportunities facing professionals engaged in the evaluation of comprehensive, community-based initiatives and other nontraditional program strategies. (Author/SLD)

  8. The TIPS Evaluation Project: A Theory-Driven Approach to Dissemination Research.

    ERIC Educational Resources Information Center

    Mulvey, Kevin P.; Hayashi, Susan W.; Hubbard, Susan M.; Kopstien, Andrea; Huang, Judy Y.

    2003-01-01

    Introduces the special section that focuses on four major studies under the treatment improvement protocols (TIPs) evaluation project. Provides an overview of each article, and addresses the value of using a theory-driven approach to dissemination research. (SLD)

  9. William J. Brennan Jr.: Judicial Architect of Affirmative Action.

    ERIC Educational Resources Information Center

    Eisler, Kim Isaac

    1997-01-01

    More than any other Supreme Court Justice, William Brennan worked to level the playing field for black Americans. As the recognized architect of affirmative action strategies for higher education, he left an indelible imprint on equal education in America. (SLD)

  10. Aids to Computer-Based Multimedia Learning.

    ERIC Educational Resources Information Center

    Mayer, Richard E.; Moreno, Roxana

    2002-01-01

    Presents a cognitive theory of multimedia learning that draws on dual coding theory, cognitive load theory, and constructivist learning theory and derives some principles of instructional design for fostering multimedia learning. These include principles of multiple representation, contiguity, coherence, modality, and redundancy. (SLD)

  11. Dissecting Practical Intelligence Theory: Its Claims and Evidence.

    ERIC Educational Resources Information Center

    Gottfredson, Linda S.

    2003-01-01

    The two key theoretical propositions of "Practical Intelligence in Everyday Life" are made plausible only if one ignores considerable evidence contradicting them. The six key empirical claims rest primarily on the illusion of evidence enhanced by selective reporting of results. (SLD)

  12. Psychotherapy of Depression: A Self-Confirmation Model.

    ERIC Educational Resources Information Center

    Andrews, John D. W.

    1989-01-01

    Concepts of self-confirmation, interpersonal diagnosis, and prototype construction are used to integrate research and clinical findings concerning depression. Various theoretical accounts and bodies of data that fit within this integrative conceptual framework are examined, and implications for psychotherapy are discussed. (SLD)

  13. Employment Discrimination in Higher Education.

    ERIC Educational Resources Information Center

    Hustoles, Thomas P.; Griffin, Oren R.

    2000-01-01

    Reviews court decisions related to employment discrimination in higher education. The most significant development was a series of cases affirming that Eleventh Amendment immunity from private money damage claims brought pursuant to various federal employment discrimination statutes applied to state colleges and universities. (SLD)

  14. Think before for a Better After.

    ERIC Educational Resources Information Center

    Diskin, Brooke; Mullen, Kyla; Lancaster, Kate

    2003-01-01

    Describes a campaign to promote recycling and energy and water conservation at the California Polytechnic State University campus in San Luis Obispo. The student-led effort influenced students to think about their actions and change their behaviors to be more eco-friendly. (SLD)

  15. On Structural Equation Model Equivalence.

    ERIC Educational Resources Information Center

    Raykov, Tenko; Penev, Spiridon

    1999-01-01

    Presents a necessary and sufficient condition for the equivalence of structural-equation models that is applicable to models with parameter restrictions and models that may or may not fulfill assumptions of the rules. Illustrates the application of the approach for studying model equivalence. (SLD)

  16. Huddle: At DeMatha High, Football Is Family.

    ERIC Educational Resources Information Center

    Asayesh, Gelareh

    1993-01-01

    The football program at DeMatha High School in Hyattsville (Maryland), illustrates ways in which a sports program can build unity and racial tolerance among students. The shared team effort carries over into schoolwork and life outside of school. (SLD)

  17. Italian Version of the Self-Description Questionnaire-III.

    ERIC Educational Resources Information Center

    Maggi, Stefania

    2001-01-01

    Developed an Italian version of the Self-Description Questionnaire (SDQ-III) and studied the reliability and factorial validity of this translated instrument. Results show that the translated version has psychometric properties similar to those of the original English version. (SLD)

  18. An Evaluation Network for Educational Change.

    ERIC Educational Resources Information Center

    Marchesi, Alvaro; Martin, Elena; Martinez Arias, Rosario; Tiana, Alejandro; Moreno, Amparo

    2003-01-01

    Describes the experience of an evaluation network being put into practice in Spain to encourage educational change. Outlines the most relevant conditions needed for educational change and develops the description of a school evaluation network that includes all the previously described conditions. (SLD)

  19. What Glass Ceiling?

    ERIC Educational Resources Information Center

    Lynch, Michael; Post, Katherine

    1996-01-01

    A recent study drawing on data from the Census Bureau and the Bureau of Labor Statistics suggests that the wage gap between men and women has virtually disappeared, and that the so-called "glass ceiling" results more from age and qualifications than from explicit discrimination. (SLD)

  20. Empirical Bayes Approaches to Multivariate Fuzzy Partitions.

    ERIC Educational Resources Information Center

    Woodbury, Max A.; Manton, Kenneth G.

    1991-01-01

    An empirical Bayes-maximum likelihood estimation procedure is presented for the application of fuzzy partition models in describing high dimensional discrete response data. The model describes individuals in terms of partial membership in multiple latent categories that represent bounded discrete spaces. (SLD)

  1. Repatriation and Reintegration of Unaccompanied Refugee Children.

    ERIC Educational Resources Information Center

    Migration World Magazine, 1998

    1998-01-01

    The international community must protect the rights of unaccompanied refugee children as they are repatriated or resettled into their own countries. The establishment of guidelines to ensure this and the creation of an independent watch group to monitor reintegration are recommended. (SLD)

  2. Self-Esteem Goes Political.

    ERIC Educational Resources Information Center

    Jones, Regina

    1990-01-01

    Lack of self-esteem is the root of many social problems. The California Task Force to Promote Self-Esteem and Personal and Social Responsibility has made several recommendations to promote self-esteem as a social vaccine against the problems besetting minority and urban families. (SLD)

  3. Richard Wright: Climate of Fear and Violence.

    ERIC Educational Resources Information Center

    Nnaemeka, Obioma

    1992-01-01

    In his works, Richard Wright denounces murder while advocating collectivism as an essential ingredient for effecting social change. The short story collection "Uncle Tom's Children" and the novel "Native Son" are the focal points in this analysis of Wright's recurring themes. (SLD)

  4. Expert Panels, Consumers, and Chemistry.

    ERIC Educational Resources Information Center

    Rehfeldt, Thomas K.

    2000-01-01

    Studied the attributes, properties, and consumer acceptance of antiperspirant products through responses of 400 consumers (consumer data), expert panel data, and analytical data about the products. Results show how the Rasch model can provide the tool necessary to combine data from several sources. (SLD)

  5. The Jewish Ethical Tradition in the Modern University.

    ERIC Educational Resources Information Center

    Novak, David

    1998-01-01

    Proposes an interpretation of pluralism and multiculturalism that separates these concepts from the notions of relativism. Asserts that the inclusion of formerly excluded cultural traditions such as Judaism in North American universities has been a give-and-take enterprise. (SLD)

  6. Trainee Characteristics and Perceptions of HIV/AIDS Training Quality.

    ERIC Educational Resources Information Center

    Panter, A. T.; Huba, G. J.; Melchior, Lisa A.; Anderson, Donna; Driscoll, Mary; German, Victor F.; Henderson, Harold; Henderson, Ron; Lalonde, Bernadette; Uldall, Karnina K.; Zalumas, Jacqueline

    2000-01-01

    Reports findings from 7 HIV/AIDS education and training projects involving more than 600 training sessions. Trainee characteristics were related to their assessments of training quality, using a regression decision-tree analytic approach. Discusses implications for curriculum development. (SLD)

  7. Complex Problem Solving in a Workplace Setting.

    ERIC Educational Resources Information Center

    Middleton, Howard

    2002-01-01

    Studied complex problem solving in the hospitality industry through interviews with six office staff members and managers. Findings show it is possible to construct a taxonomy of problem types and that the most common approach can be termed "trial and error." (SLD)

  8. Payment and Provider Profiling of Episodes of Illness of Clinical Illnesses Involving Rehabilitation.

    ERIC Educational Resources Information Center

    Goldfield, Norbert; Averill, Richard; Eisenhandler, Jon; Hughes, John S.; Muldoon, John; Steinbeck, Barbara; Bagadia, Farah

    2001-01-01

    Summarizes the development of a new risk adjustment methodology, the Clinical Risk Grouping System, a prospective capitation risk adjuster, that should be useful for payment and monitoring of episodes of clinical conditions that involve rehabilitation. (SLD)

  9. Comment on "Histories and Horoscopes: The Ethnographer as Fortune-Teller."

    ERIC Educational Resources Information Center

    Luttrell, Wendy

    1998-01-01

    Explores the analogy of the researcher as fortune teller and the parallels between research histories and horoscopes and discusses the tension between what the subject is and what he or she is imagined to be by others. (SLD)

  10. Ethnic Segregation in Arizona Charter Schools.

    ERIC Educational Resources Information Center

    Cobb, Casey D.; Glass, Gene V.

    1999-01-01

    Addressed whether Arizona charter schools were more ethnically segregated than traditional public schools by studying 55 urban and 57 rural charter schools. Nearly half showed evidence of substantial ethnic segregation, and charter schools were higher in white enrollment than other public schools. (SLD)

  11. Good Effective School Improvement Practices in Spain.

    ERIC Educational Resources Information Center

    Murillo, F. Javier

    2002-01-01

    Presents case studies of five effective school improvement (ESI) programs developed in Spain. Identified characteristics of the Spanish education system that affect the way ESI programs are carried out and developed descriptions of the five programs and lessons learned from them. (SLD)

  12. Working with Hassan.

    ERIC Educational Resources Information Center

    Crabb, Ruth

    1996-01-01

    The action research case study of the introduction of a Somali refugee child to a London (England) primary school illustrates the importance of finding ways to communicate with the child, who spoke no English, and preparing the other students to accept cultural and linguistic difference. (SLD)

  13. Lessons Learned about the Methodology of Economic Impact Studies: The NIST Experience.

    ERIC Educational Resources Information Center

    Tassey, Gregory

    1999-01-01

    Summarizes ongoing economic impact assessment activities at the National Institute of Standards and Technology (NIST) for its Measurement and Standards Laboratory Program. Explores designing economic impact studies for integration into assessments of broader programmatic objectives. (SLD)

  14. Making Sense of the Data from Complex Assessments.

    ERIC Educational Resources Information Center

    Mislevy, Robert J.; Steinberg, Linda S.; Breyer, F. Jay; Almond, Russell G.; Johnson, Lynn

    2002-01-01

    Presents a design framework that incorporates integrated structures for modeling knowledge and skills, designing tasks, and extracting and synthesizing evidence. Illustrates these ideas in the context of a project that assesses problem solving in dental hygiene through computer-based simulations. (SLD)

  15. Reflections on Empowerment Evaluation: Learning from Experience.

    ERIC Educational Resources Information Center

    Fetterman, David M.

    1999-01-01

    Reflects on empowerment evaluation, the use of evaluation to foster improvement and self-determination. Empowerment evaluation uses quantitative and qualitative methods, and usually focuses on program evaluation. Discusses the growth in empowerment evaluation as a result of interest in participatory evaluation. (SLD)

  16. Presidential Address: Empowerment Evaluation.

    ERIC Educational Resources Information Center

    Fetterman, David

    1994-01-01

    Empowerment evaluation is the use of evaluation concepts and techniques to foster self-determination, focusing on helping people help themselves. This collaborative evaluation approach requires both qualitative and quantitative methodologies. It is a multifaceted approach that can be applied to evaluation in any area. (SLD)

  17. The TIMSS 1999 Video Study and the Reform of Mathematics Teaching. Invited Commentary.

    ERIC Educational Resources Information Center

    Cooney, Thomas J.

    2003-01-01

    The report on the Third International Mathematics and Science Study (TIMSS) Video Study of mathematics teaching demonstrates the complexity of teaching as it provides lessons about conservatism and the role of reform in mathematics teaching. (SLD)

  18. Women in Sports: Recommended Books for Children and Teenagers.

    ERIC Educational Resources Information Center

    Goldberg, Martin

    1996-01-01

    Female sports stars featured in this annotated bibliography have excelled in a variety of sports, often overcoming prejudice and discrimination because of their gender or race. Nine general works and 41 works focusing on 28 individual athletes are cited. (SLD)

  19. Psychological Acculturation of Young Visible Immigrants.

    ERIC Educational Resources Information Center

    Sam, David Lackland

    1992-01-01

    Discusses the psychological acculturation of young visible immigrants in Western industrialized countries, examining the psychosocial milieu that parents and society provide them, and the inability to assimilate or acculturate. "Visible" immigrant is a value neutral term for nonwhite or non-Caucasian immigrants. (SLD)

  20. Incentives and Accountability: Instruments of Change in Higher Education.

    ERIC Educational Resources Information Center

    Belloc, Bernard

    2003-01-01

    Describes the increasing openness of French higher education and the move toward increasing autonomy at French institutions of higher education. Describes the incentive mechanisms of the French system and the need for an even greater degree of autonomy. (SLD)

  1. Rise of Human Intelligence: Comments on Howard (1999).

    ERIC Educational Resources Information Center

    Gobet, Fernand; Campitelli, Guillermo; Waters, Andrew J.

    2002-01-01

    Finds several difficulties with the theory advanced by R. Howard and shows that alternative explanations relating to changes in the chess environment, including increased access to chess knowledge, offer better explanations for the increased presence of young players at top-level chess. (SLD)

  2. Structural Representations in Knowledge Acquisition.

    ERIC Educational Resources Information Center

    Gonzalvo, Pilar; And Others

    1994-01-01

    Multidimensional scaling (MDS) and Pathfinder techniques for assessing changes in the structural representation of a knowledge domain were studied with relatedness ratings collected from 72 Spanish college students. Comparison of student and expert similarity measures indicate that MDS and graph theoretic approaches are valid techniques. (SLD)

  3. Computerized Adaptive Testing: From Inquiry to Operation [Book Review].

    ERIC Educational Resources Information Center

    Gierl, Mark J.

    1998-01-01

    This book documents the research, development, and implementation efforts that allowed the U.S. Department of Defense to initiate the Computerized Adaptive Testing Armed Services Vocational Aptitude Battery Program for enlistment testing. Traces the history of this program over 30 years. (SLD)

  4. Statistical Methods in Psychology Journals.

    ERIC Educational Resources Information Center

    Willkinson, Leland

    1999-01-01

    Proposes guidelines for revising the American Psychological Association (APA) publication manual or other APA materials to clarify the application of statistics in research reports. The guidelines are intended to induce authors and editors to recognize the thoughtless application of statistical methods. Contains 54 references. (SLD)

  5. Model Comparison of Nonlinear Structural Equation Models with Fixed Covariates.

    ERIC Educational Resources Information Center

    Lee, Sik-Yum; Song, Xin-Yuan

    2003-01-01

    Proposed a new nonlinear structural equation model with fixed covariates to deal with some complicated substantive theory and developed a Bayesian path sampling procedure for model comparison. Illustrated the approach with an illustrative example using data from an international study. (SLD)

  6. Generalized Appended Product Indicator Procedure for Nonlinear Structural Equation Analysis.

    ERIC Educational Resources Information Center

    Wall, Melanie M.; Amemiya, Yasuo

    2001-01-01

    Considers the estimation of polynomial structural models and shows a limitation of an existing method. Introduces a new procedure, the generalized appended product indicator procedure, for nonlinear structural equation analysis. Addresses statistical issues associated with the procedure through simulation. (SLD)

  7. The Mental Testing Community and Validity: A Prehistory.

    ERIC Educational Resources Information Center

    von Mayrhauser, Richard T.

    1992-01-01

    Examines accuracy evaluation in published testing programs of the following: J. M. Cattell; C. Spearman; A. Binet; L. M. Terman; R. M. Yerkes; E. L. Thorndike; and W. D. Scott. Developing community and consensus on testing required convergence between theorists and practitioners. (SLD)

  8. Integration and Mainstreaming of Communicatively Disordered Children.

    ERIC Educational Resources Information Center

    Moody, Janet B.; Bozeman, Rhoushelle

    The paper presents an overview of the factors involved in providing successful mainstreaming experiences to severely language disordered (SLD) children. Among aspects considered are individualization, behavior management procedures, independent problem solving and decision making, group test taking skills and experiences, social emotional growth,…

  9. Intelligence and Changes in Regional Cerebral Glucose Metabolic Rate Following Learning.

    ERIC Educational Resources Information Center

    Haier, Richard J.; And Others

    1992-01-01

    A study of eight normal right-handed men demonstrates widespread significant decreases in brain glucose metabolic rate (GMR) following learning a complex computer task, a computer game. Correlations between magnitude of GMR change and intelligence scores are also demonstrated. (SLD)

  10. ERP Software Implementation Best Practices.

    ERIC Educational Resources Information Center

    Frantz, Pollyanne S.; Southerland, Arthur R.; Johnson, James T.

    2002-01-01

    Studied the perceptions of chief financial and information officers of enterprise resource planning (ERP) software implementation best practices. Usable responses from 159 respondents show consensus for the most part between the perceptions of the two groups and describe some best practices that represent common ground. (SLD)

  11. Theoretical and Empirical Comparisons between Two Models for Continuous Item Responses.

    ERIC Educational Resources Information Center

    Ferrando, Pere J.

    2002-01-01

    Analyzed the relations between two continuous response models intended for typical response items: the linear congeneric model and Samejima's continuous response model (CRM). Illustrated the relations described using an empirical example and assessed the relations through a simulation study. (SLD)

  12. Teachers, Research, and Advocacy.

    ERIC Educational Resources Information Center

    Fruchter, Norm; Price, Janet

    1993-01-01

    Illustrates how teacher action research can be the ammunition for teacher advocacy and the cornerstone of empowerment through the example of the New York City Accountability Project. The goal of the project is to support teachers' efforts to introduce better assessment strategies that support instruction. (SLD)

  13. Resiliency Programming for Adult Offenders in Georgia.

    ERIC Educational Resources Information Center

    Rees, E. Frances

    2000-01-01

    Discusses resiliency programming as an alternative approach to program development for incarcerated adults, and describes a pilot project in a Georgia prison, Leadership Development, that uses the concept of resiliency to frame inmate education. Discusses implications of this model of correctional education. (SLD)

  14. Purchasing Nonprescription Contraceptives: The Underlying Structure of a Multi-Item Scale.

    ERIC Educational Resources Information Center

    Manolis, Chris; Winsor, Robert D.; True, Sheb L.

    1999-01-01

    Developed a multi-item scale for measuring attitudes associated with purchasing nonprescription contraceptives using construct specification and item generation and confirmatory factor analysis. Demonstrated a high degree of invariance across samples of 81 female and 115 male adult consumers. (SLD)

  15. Safety and Security by Design.

    ERIC Educational Resources Information Center

    Carter, Sherry P.

    2003-01-01

    Describes a pilot exercise in teaching middle and high school students how to conduct an assessment of the physical conditions and policies of their schools. Students were taught to use Crime Prevention through Environmental Design principles and to apply them in their own schools. (SLD)

  16. Applicant Analysis: 2001 Entering Class.

    ERIC Educational Resources Information Center

    Weaver, Richard G.; Haden, N. Karl; Ramanna, Satyan; Valachovic, Richard W.

    2003-01-01

    Presents findings of the annual analysis of dental school applicant numbers and characteristics conducted by the American Dental Education Association. There were 7,412 applicants to dental schools in 2001, and 57.6% were enrolled in 2001. Provides other data about applicants and admissions. (SLD)

  17. Tests, Abilities, Race, and Conflict.

    ERIC Educational Resources Information Center

    Elliott, Rogers

    1988-01-01

    Relationship between ability tests and race and issues of famous lawsuits concerning possible bias in intelligence tests are summarized. Reasons for the origins of ethnic and racial differences in general intellectual ability are considered. Prospects for the reduction of group differences and conflicts are discussed. (SLD)

  18. Cross-Sectional Time Series Designs: A General Transformation Approach.

    ERIC Educational Resources Information Center

    Velicer, Wayne F.; McDonald, Roderick P.

    1991-01-01

    The general transformation approach to time series analysis is extended to the analysis of multiple unit data by the development of a patterned transformation matrix. The procedure includes alternatives for special cases and requires only minor revisions in existing computer software. (SLD)

  19. The Demonization of Multiculturalism.

    ERIC Educational Resources Information Center

    Rorty, Richard

    1995-01-01

    Attacks on multiculturalism in higher education as threatening free speech and genuine diversity of opinion have no basis in fact, but they may be expected to continue as the political Right realizes that the American academy is the last defender of the poor and the weak. (SLD)

  20. Food for Thought: Cross-Classification and Category Organization in a Complex Real-World Domain.

    ERIC Educational Resources Information Center

    Ross, Brian H.; Murphy, Gregory L.

    1999-01-01

    Seven studies involving 256 undergraduates examined how people represent, access, and make inferences about the real-world category domain, foods. Results give a detailed picture of the use of cross-classification in a complex domain. (SLD)

  1. Program Evaluation of Services for the Homeless: Challenges and Strategies.

    ERIC Educational Resources Information Center

    Mercier, Celine; And Others

    1992-01-01

    Research strategies, including types of evaluations, designs, and indicators, developed to assess programs for chronic alcoholics and mentally ill homeless people in Canada are reviewed. Findings from previous evaluations are summarized, and the implications for evaluation practice are considered. (SLD)

  2. How To Renovate for Sustainability.

    ERIC Educational Resources Information Center

    Sturgeon, Julie

    2003-01-01

    Suggests ways to renovate buildings with sustainability in mind, with specific tips in the areas of: (1) lights; energy management; (3) walls and roofs; (4) water; and (5) aesthetics. No one thing will make a building sustainable; it is the aggregate that makes it effective. (SLD)

  3. The Gun Dispute.

    ERIC Educational Resources Information Center

    Spitzer, Robert J.

    1999-01-01

    Explores the debate over gun ownership and gun control in the United States, focusing on the historic place of guns in U.S. society. The current national mood is more receptive than ever to restricting and regulating adolescent access to guns in light of recent school shootings. (SLD)

  4. Claude McKay: Black Protest in Western Traditional Form.

    ERIC Educational Resources Information Center

    Hudson-Weems, Clenora

    1992-01-01

    The protest poetry of Claude McKay, a leading writer of the Harlem Renaissance, is couched in the Western sonnet form. How the poetic form supports or conflicts with the messages of African-American pride and contempt for racism is examined. (SLD)

  5. Teaching Multiplication with Regrouping to Students with Learning Disabilities

    ERIC Educational Resources Information Center

    Flores, Margaret M.; Hinton, Vanessa M.; Schweck, Kelly B.

    2014-01-01

    The Common Core Standards require demonstration of conceptual knowledge of numbers, operations, and relations between mathematical concepts. Supplemental instruction should explicitly guide students with specific learning disabilities (SLD) in these skills. In this article, we illustrate implementation of the concrete-representational-abstract…

  6. A Social-Cognitive Approach to Motivation and Personality.

    ERIC Educational Resources Information Center

    Dweck, Carol S.; Leggett, Ellen L.

    1988-01-01

    A research-based model is presented that accounts for major patterns of adaptive and maladaptive behavior in terms of underlying psychological processes. It is postulated that as individuals' self-attributes are translated into allied goals, these goals generate corresponding behavior patterns. (SLD)

  7. Conditional Standard Errors of Measurement for Scale Scores.

    ERIC Educational Resources Information Center

    Kolen, Michael J.; And Others

    1992-01-01

    A procedure is described for estimating the reliability and conditional standard errors of measurement of scale scores incorporating the discrete transformation of raw scores to scale scores. The method is illustrated using a strong true score model, and practical applications are described. (SLD)

  8. Reliability Generalization of the Alcohol Use Disorder Identification Test.

    ERIC Educational Resources Information Center

    Shields, Alan L.; Caruso, John C.

    2002-01-01

    Evaluated the reliability of scores from the Alcohol Use Disorders Identification Test (AUDIT; J. Sounders and others, 1993) in a reliability generalization study based on 17 empirical journal articles. Results show AUDIT scores to be generally reliable for basic assessment. (SLD)

  9. Daily Routines and Crime: Using Routine Activities as Measures of Hirschi's Involvement.

    ERIC Educational Resources Information Center

    Hawdon, James E.

    1999-01-01

    Reconstitutes the "involvement" aspect of T. Hirschi's bond theory to substitute routine-activity patterns (RAPs) for involvement. Self-reports of 108 college freshmen suggest that involvement reconstituted as RAPs is an effective predictor of minor acts of delinquency. (SLD)

  10. Multicategorical Spline Model for Item Response Theory.

    ERIC Educational Resources Information Center

    Abrahamowicz, Michal; Ramsay, James O.

    1992-01-01

    A nonparametric multicategorical model for multiple-choice data is proposed as an extension of the binary spline model of J. O. Ramsay and M. Abrahamowicz (1989). Results of two Monte Carlo studies illustrate the model, which approximates probability functions by rational splines. (SLD)

  11. Social Inclusion: Would Dickens Approve?

    ERIC Educational Resources Information Center

    Nickson, Kathleen

    2000-01-01

    Discusses exclusion of ethnic minority students from school in Britain as it reflects the operation of complex differential expectations and assumptions. Data from several studies show that exclusions have been racialized and that black boys are often excluded or disciplined for showing culturally specific behaviors. (SLD)

  12. Ethnoviolence at Work.

    ERIC Educational Resources Information Center

    Weiss, Joan C.; And Others

    1992-01-01

    The National Victimization Project of the National Institute Against Prejudice and Violence attempted to understand violence motivated by prejudice in the United States. Interviews with 1,372 employed people confirmed the prevalence and costliness of ethnoviolence in the workplace. Human rights agencies need to address this problem. (SLD)

  13. Evaluation: Review of the Past, Preview of the Future.

    ERIC Educational Resources Information Center

    Smith, M. F.

    1994-01-01

    This paper summarized contributors' ideas about evaluation as a field and where it is going. Topics discussed were qualitative versus quantitative debate; evaluation's purpose; professionalization; program failure; program development; evaluators as advocates; evaluation knowledge; evaluation expansion; and methodology and design. (SLD)

  14. Reconceptualization of African American Self-Concept.

    ERIC Educational Resources Information Center

    Braithwaite, Harold, Jr.; And Others

    1994-01-01

    Focuses on how African American students define self-concept, and whether there is a specific black self-concept. Questionnaires completed by 60 undergraduates at a historically black college provide insight into student self-esteem and support the existence of a specific black self-concept. (SLD)

  15. Intelligence Differentiation in Adult Samples.

    ERIC Educational Resources Information Center

    Abad, Francisco J.; Colom, Robert; Juan-Espinosa, Manuel; Garcia, Luis F.

    2003-01-01

    Results for 3,340 participants taking a battery of cognitive tests and an analysis of the Spanish standardization of the Wechsler Adult Intelligence Scale-III support the differentiation of intelligence across the range of ability, with WAIS-III results more supportive of the differentiation theory. (SLD)

  16. Generalizability and Validity of a Mathematics Performance Assessment.

    ERIC Educational Resources Information Center

    Lane, Suzanne; And Others

    1996-01-01

    Evidence from test results of 3,604 sixth and seventh graders is provided for the generalizability and validity of the Quantitative Understanding: Amplifying Student Achievement and Reasoning (QUASAR) Cognitive Assessment Instrument, which is designed to measure program outcomes and growth in mathematics. (SLD)

  17. The Spin Zone: Choosing Laundry Equipment.

    ERIC Educational Resources Information Center

    Milshtein, Amy

    2003-01-01

    Discusses whether or not a college or university should own its own laundry equipment or contract out laundry services, including machine maintenance, and outlines the advantages of different types of washing machines for the student housing setting. Also reviews issues related to payment methods. (SLD)

  18. An Aspect of Political Socialization of Student Movement Participants in Korea.

    ERIC Educational Resources Information Center

    Park, Byeong-chul

    1993-01-01

    Tests hypotheses from lineage socialization and generation unit perspectives on Korean student protest participation using 360 self-administered questionnaires collected at 3 Korean universities. Results indicate that these hypotheses are not mutually exclusive but support the generation unit model. (SLD)

  19. Commentary on Values and Standards in Performance Assessment.

    ERIC Educational Resources Information Center

    Guion, Robert M.

    1995-01-01

    This commentary discusses three essential themes in performance assessment and its scoring. First, scores should mean something. Second, performance scores should permit fair and meaningful comparisons. Third, validity-reducing errors should be minimal. Increased attention to performance assessment may overcome these problems. (SLD)

  20. Metaphors for Learning: Cognitive Acquisition versus Social Participation.

    ERIC Educational Resources Information Center

    Elmholdt, Claus

    2003-01-01

    Analyzed expressions of cognitive "acquisition" and social "participation" metaphors for learning in the practice of support people in an information and communication technology company department of 100 employees. Findings show the support people's practice is characterized by interplay between these two metaphors. (SLD)

  1. Sharing the Code.

    ERIC Educational Resources Information Center

    Olsen, Florence

    2003-01-01

    Colleges and universities are beginning to consider collaborating on open-source-code projects as a way to meet critical software and computing needs. Points out the attractive features of noncommercial open-source software and describes some examples in use now, especially for the creation of Web infrastructure. (SLD)

  2. The Status of the Mastitubari.

    ERIC Educational Resources Information Center

    Lei-Lanilau, Carolyn; Peyton-Caire, Lisa; Perkins, Judith

    2000-01-01

    This kinesthetic piece evokes and provokes the reader into a visceral experience that transfers the internal emotional reactions of women of color as they face a world that does not value their worth as leaders. Explores issues of leadership through parallels with masturbation. (Author/SLD)

  3. Outcomes Research and the Quality of Health Care: The Beacon of an Ethics of Evidence.

    ERIC Educational Resources Information Center

    Mike, Valerie

    1999-01-01

    Proposes an "ethics of evidence" as an approach to medical uncertainty and a vital component of biomedical ethics. Calls for use of the best possible scientific evidence for every phase of medical decision making. (SLD)

  4. Race and Education: A Review Essay.

    ERIC Educational Resources Information Center

    Wieder, Alan

    1994-01-01

    This review essay extends the thesis of Douglas Massey and Nancy Denton, that the continuing cause of the underclass is neighborhood segregation, to cover school segregation. Continuing costs of school segregation, racial tension and white racism, and reinvestment in school integration are also explored. (SLD)

  5. Geographic Information Systems (GIS) as an Evaluation Tool.

    ERIC Educational Resources Information Center

    Renger, Ralph; Cimetta, Adriana; Pettygrove, Sydney; Rogan, Seumas

    2002-01-01

    Describes how Geographic Information Systems (GIS) can be used to help evaluators convey complex information simply through a spatial representation. Demonstrates how GIS can be used to plot change over time, including impact and outcome data gathered by primary data collection. (SLD)

  6. Buying Fiber-Optic Networks.

    ERIC Educational Resources Information Center

    Fickes, Michael

    2003-01-01

    Describes consortia formed by college and university administrators to buy, manage, and maintain their own fiber-optic networks with the goals of cutting costs of leasing fiber-optic cable and planning for the future. Growth capacity is the real advantage of owning fiber-optic systems. (SLD)

  7. A Taxonomy of Latent Structure Assumptions for Probability Matrix Decomposition Models.

    ERIC Educational Resources Information Center

    Meulders, Michel; De Boeck, Paul; Van Mechelen, Iven

    2003-01-01

    Proposed a taxonomy of latent structure assumptions for probability matrix decomposition (PMD) that includes the original PMD model and a three-way extension of the multiple classification latent class model. Simulation study results show the usefulness of the taxonomy. (SLD)

  8. An Empirical Bayes Approach to Mantel-Haenszel DIF Analysis.

    ERIC Educational Resources Information Center

    Zwick, Rebecca; Thayer, Dorothy T.; Lewis, Charles

    1999-01-01

    Developed an empirical Bayes enhancement to Mantel-Haenszel (MH) analysis of differential item functioning (DIF) in which it is assumed that the MH statistics are normally distributed and that the prior distribution of underlying DIF parameters is also normal. (Author/SLD)

  9. A Behavioral Theory of Timing.

    ERIC Educational Resources Information Center

    Killeen, Peter R.; Fetterman, J. Gregor

    1988-01-01

    A theory of timing is proposed, based on the observation that signals of reinforcement elicit adjunctive behaviors. Transitions between these behaviors are described as a Poisson process. These behaviors may come to serve as the basis for conditional discriminations of the passage of time. (SLD)

  10. The Practitioner's Corner: Special Editorial Announcement.

    ERIC Educational Resources Information Center

    Annunziata, Joyce

    2000-01-01

    The "Journal of Personnel Evaluation in Education" announces the establishment of a new section, "The Practitioner's Corner," a section that will provide the opportunity for practitioners from many educational environments to share information about issues, controversies, and programs in personnel evaluation that reflect practice. (SLD)

  11. Reconsidering the Status of Title IX.

    ERIC Educational Resources Information Center

    Hammer, Ben

    2003-01-01

    Discusses the controversy over Title IX and women's participation in college athletics. Critics say the mandate shortchanges men's teams, while proponents say that women's sports programs remain underfunded in spite of Title IX. Describes some proposed modifications to Title IX and their potential effects. (SLD)

  12. Conditional Covariance-Based Nonparametric Multidimensionality Assessment.

    ERIC Educational Resources Information Center

    Stout, William; And Others

    1996-01-01

    Three nonparametric procedures that use estimates of covariances of item-pair responses conditioned on examinee trait level for assessing dimensionality of a test are described. The HCA/CCPROX, DIMTEST, and DETECT are applied to a dimensionality study of the Law School Admission Test. (SLD)

  13. Assessment and Classification of Attention Deficit Hyperactive Disorders.

    ERIC Educational Resources Information Center

    Schaughency, Elizabeth A.; Rothlind, Johannes

    1991-01-01

    Issues concerning evaluation, assessment, and classification of Attention-Deficit Hyperactive Disorders (ADHD) are discussed. The diagnosis of ADHD should be a best-estimate diagnosis, based on a behavioral assessment strategy with multimethod assessment. The selection and use of assessment techniques are discussed. (SLD)

  14. The use of technology for delivering a weight loss program for adolescents with intellectual and developmental disabilities.

    PubMed

    Ptomey, Lauren T; Sullivan, Debra K; Lee, Jaehoon; Goetz, Jeannine R; Gibson, Cheryl; Donnelly, Joseph E

    2015-01-01

    Adolescents with intellectual and developmental disabilities (IDD) are at an increased risk of obesity, with up to 55% considered overweight and 31% obese. However, there has been minimal research on weight management strategies for adolescents with IDD. The purpose of this study was to compare the effectiveness of two weight loss diets, an enhanced Stop Light Diet (eSLD) and a conventional diet (CD), and to determine the feasibility of using tablet computers as a weight loss tool in overweight and obese adolescents with IDD. A 2-month pilot intervention was conducted. All participants were randomized to the eSLD or CD and were given a tablet computer that they used to track daily dietary intake and physical activity. Participants and parents met weekly with a registered dietitian nutritionist via video chat on the tablet computer to receive diet and physical activity feedback and education. Twenty participants (45% female, aged 14.9±2.2 years) were randomized and completed the intervention. Participants in both diets were able to lose weight, and there were no significant differences between the eSLD and CD (-3.89±2.66 kg vs -2.22±1.37 kg). Participants were able to use the tablet computer to track their dietary intake 83.4%±21.3% of possible days and to attend 80.0% of the video chat meetings. Both dietary interventions appear to promote weight loss in adolescents with IDD, and the use of tablet computers appears to be a feasible tool to deliver a weight loss intervention in adolescents with IDD. Copyright © 2015 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  15. Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast.

    PubMed

    Wolinski, Heimo; Hofbauer, Harald F; Hellauer, Klara; Cristobal-Sarramian, Alvaro; Kolb, Dagmar; Radulovic, Maja; Knittelfelder, Oskar L; Rechberger, Gerald N; Kohlwein, Sepp D

    2015-11-01

    Yeast Fld1 and Ldb16 resemble mammalian seipin, implicated in neutral lipid storage. Both proteins form a complex at the endoplasmic reticulum-lipid droplet (LD) interface. Malfunction of this complex either leads to LD clustering or to the generation of supersized LD (SLD) in close vicinity to the nuclear envelope, in response to altered phospholipid (PL) composition. We show that similar to mutants lacking Fld1, deletion of LDB16 leads to abnormal proliferation of a subdomain of the nuclear envelope, which is tightly associated with clustered LD. The human lipin-1 ortholog, the PAH1 encoded phosphatidic acid (PA) phosphatase, and its activator Nem1 are highly enriched at this site. The specific accumulation of PA-binding marker proteins indicates a local enrichment of PA in the fld1 and ldb16 mutants. Furthermore, we demonstrate that clustered LD in fld1 or ldb16 mutants are transformed to SLD if phosphatidylcholine synthesis is compromised by additional deletion of the phosphatidylethanolamine methyltransferase, Cho2. Notably, treatment of wild-type cells with oleate induced a similar LD clustering and nuclear membrane proliferation phenotype as observed in fld1 and ldb16 mutants. These data suggest that the Fld1-Ldb16 complex affects PA homeostasis at an LD-forming subdomain of the nuclear envelope. Lack of Fld1-Ldb16 leads to locally elevated PA levels that induce an abnormal proliferation of nER membrane structures and the clustering of associated LD. We suggest that the formation of SLD is a consequence of locally altered PL metabolism at this site. Copyright © 2015. Published by Elsevier B.V.

  16. Additional Results of Glaze Icing Scaling in SLD Conditions

    NASA Technical Reports Server (NTRS)

    Tsao, Jen-Ching

    2016-01-01

    New guidance of acceptable means of compliance with the super-cooled large drops (SLD) conditions has been issued by the U.S. Department of Transportation's Federal Aviation Administration (FAA) in its Advisory Circular AC 25-28 in November 2014. The Part 25, Appendix O is developed to define a representative icing environment for super-cooled large drops. Super-cooled large drops, which include freezing drizzle and freezing rain conditions, are not included in Appendix C. This paper reports results from recent glaze icing scaling tests conducted in NASA Glenn Icing Research Tunnel (IRT) to evaluate how well the scaling methods recommended for Appendix C conditions might apply to SLD conditions. The models were straight NACA 0012 wing sections. The reference model had a chord of 72 inches and the scale model had a chord of 21 inches. Reference tests were run with airspeeds of 100 and 130.3 knots and with MVD's of 85 and 170 microns. Two scaling methods were considered. One was based on the modified Ruff method with scale velocity found by matching the Weber number W (sub eL). The other was proposed and developed by Feo specifically for strong glaze icing conditions, in which the scale liquid water content and velocity were found by matching reference and scale values of the non-dimensional water-film thickness expression and the film Weber number W (sub ef). All tests were conducted at 0 degrees angle of arrival. Results will be presented for stagnation freezing fractions of 0.2 and 0.3. For non-dimensional reference and scale ice shape comparison, a new post-scanning ice shape digitization procedure was developed for extracting 2-dimensional ice shape profiles at any selected span-wise location from the high fidelity 3-dimensional scanned ice shapes obtained in the IRT.

  17. Additional Results of Glaze Icing Scaling in SLD Conditions

    NASA Technical Reports Server (NTRS)

    Tsao, Jen-Ching

    2016-01-01

    New guidance of acceptable means of compliance with the super-cooled large drops (SLD) conditions has been issued by the U.S. Department of Transportation's Federal Aviation Administration (FAA) in its Advisory Circular AC 25-28 in November 2014. The Part 25, Appendix O is developed to define a representative icing environment for super-cooled large drops. Super-cooled large drops, which include freezing drizzle and freezing rain conditions, are not included in Appendix C. This paper reports results from recent glaze icing scaling tests conducted in NASA Glenn Icing Research Tunnel (IRT) to evaluate how well the scaling methods recommended for Appendix C conditions might apply to SLD conditions. The models were straight NACA 0012 wing sections. The reference model had a chord of 72 in. and the scale model had a chord of 21 in. Reference tests were run with airspeeds of 100 and 130.3 kn and with MVD's of 85 and 170 micron. Two scaling methods were considered. One was based on the modified Ruff method with scale velocity found by matching the Weber number WeL. The other was proposed and developed by Feo specifically for strong glaze icing conditions, in which the scale liquid water content and velocity were found by matching reference and scale values of the nondimensional water-film thickness expression and the film Weber number Wef. All tests were conducted at 0 deg AOA. Results will be presented for stagnation freezing fractions of 0.2 and 0.3. For nondimensional reference and scale ice shape comparison, a new post-scanning ice shape digitization procedure was developed for extracting 2-D ice shape profiles at any selected span-wise location from the high fidelity 3-D scanned ice shapes obtained in the IRT.

  18. Chemical Kinetic and Molecular Genetic Study of Selenium Oxyanion Reduction by Enterobactor cloacae SLD1a-1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ma,J.; Kobayashi, D.; Yee, N.

    2007-01-01

    Microbial processes play an important role in the redox transformations of toxic selenium oxyanions. In this study, we employed chemical kinetic and molecular genetic techniques to investigate the mechanisms of Se(IV) and Se(VI) reduction by the facultative anaerobe Enterobacter cloacae SLD1a-1. The rates of microbial selenium oxyanion reduction were measured as a function of initial selenium oxyanion concentration (0-1.0 mM) and temperature (10-40 C), and mutagenesis studies were performed to identify the genes involved in the selenium oxyanion reduction pathway. The results indicate that Se(IV) reduction is significantly more rapid than the reduction of Se(VI). The kinetics of the reductionmore » reactions were successfully quantified using the Michaelis-Menten kinetic equation. Both the rates of Se(VI) and Se(IV) reduction displayed strong temperature-dependence with Ea values of 121 and 71.2 kJ/mol, respectively. X-ray absorption near-edge spectra collected for the precipitates formed by Se(VI) and Se(IV) reduction confirmed the formation of Se(0). A miniTn5 transposon mutant of E. cloacae SLD1a-1 was isolated that had lost the ability to reduce Se(VI) but was not affected in Se(IV) reduction activity. Nucleotide sequence analysis revealed the transposon was inserted within a tatC gene, which encodes for a central protein in the twin arginine translocation system. Complementation by the wild-type tatC sequence restored the ability of mutant strains to reduce Se(VI). The results suggest that Se(VI) reduction activity is dependent on enzyme export across the cytoplasmic membrane and that reduction of Se(VI) and Se(IV) are catalyzed by different enzymatic systems.« less

  19. Understanding the Strengths of African American Families.

    ERIC Educational Resources Information Center

    Littlejohn-Blake, Sheila M.; Darling, Carol Anderson

    1993-01-01

    Focuses on strengths of African-American families and how they function, relevant conceptual approaches, and trends and issues in studying African-American families that can facilitate understanding. A shift from studying dysfunctional families to more positive aspects can help African-American families meet societal challenges. (SLD)

  20. Children and Divorce: Overview and Analysis.

    ERIC Educational Resources Information Center

    Behrman, Richard E.; Quinn, Linda Sandham

    1994-01-01

    About 26% of all children under age 18 live with a divorced or separated parent or with a stepparent. Since divorce is a crucial factor in the lives of millions of children in this country, this issue is devoted to its social, economic, and psychological impacts. (SLD)

  1. Mainstream Science on Intelligence: An Editorial with 52 Signatories, History, and Bibliography.

    ERIC Educational Resources Information Center

    Gottfredson, Linda S.

    1997-01-01

    This statement signed by 52 researchers outlines conclusions regarded as mainstream among researchers on intelligence, especially on the nature, origins, and practical consequences of individual and group differences in intelligence. The survey from which the statement was developed is described. (SLD)

  2. Discrete Mathematics and Curriculum Reform.

    ERIC Educational Resources Information Center

    Kenney, Margaret J.

    1996-01-01

    Defines discrete mathematics as the mathematics necessary to effect reasoned decision making in finite situations and explains how its use supports the current view of mathematics education. Discrete mathematics can be used by curriculum developers to improve the curriculum for students of all ages and abilities. (SLD)

  3. Residence Hall Seating That Works.

    ERIC Educational Resources Information Center

    Wiens, Janet

    2003-01-01

    Describes the seating chosen for residence halls at the Massachusetts Institute of Technology and the University of New England. The seating required depends on ergonomics, aesthetics, durability, cost, and code requirements. In addition, residence halls must have a range of seating types to accommodate various uses. (SLD)

  4. Full Weight of Evidence as Opposed to Selective Emphasis: A Response to the Critique by Gredler and Shields.

    ERIC Educational Resources Information Center

    Prawat, Richard S.

    2003-01-01

    Criticizes the evidence used by M. Gredler and C. Shields in their critique of Prawat's article about John Dewey and Lev Vygotsky and their educational philosophies. Notes specific problems with citations and interpretations. (SLD)

  5. Extended Year, Extended Contracts: Increasing Teacher Salary Options.

    ERIC Educational Resources Information Center

    Gandara, Patricia

    1992-01-01

    Reports on an attempt to raise teacher salaries through an extended contract made possible through year-round school schedules. Teacher satisfaction with the 1987 experiment in three California schools (the Orchard Plan) has been high. Elements that have contributed to job satisfaction are discussed. (SLD)

  6. Analysis of Levene's Test under Design Imbalance.

    ERIC Educational Resources Information Center

    Keyes, Tim K.; Levy, Martin S.

    1997-01-01

    H. Levene (1960) proposed a heuristic test for heteroscedasticity in the case of a balanced two-way layout, based on analysis of variance of absolute residuals. Conditions under which design imbalance affects the test's characteristics are identified, and a simple correction involving leverage is proposed. (SLD)

  7. Black Magazines: Optimism Abounds Despite Racism and Recession.

    ERIC Educational Resources Information Center

    Johnson, D. Pepper

    1991-01-01

    Along with the rest of the media, the black magazine industry is currently struggling to survive in tough economic times. However, publishers and editors express confidence in their survival because they meet the needs of their readership, needs that are not met elsewhere. (SLD)

  8. Asian American Cultural Resistance.

    ERIC Educational Resources Information Center

    Libretti, Tim

    1997-01-01

    Explores the encounter of Marxism and Asian American literary theory and imagines an Asian American Marxism. To do so requires theorizing race, class, and gender not as substantive categories of antagonisms but as complementary and coordinated elements of a totality of social relations structuring racial patriarchal capitalism. (SLD)

  9. "Going Green": Mythologies of Consumption in Adolescent Magazines.

    ERIC Educational Resources Information Center

    Currie, Dawn H.

    1994-01-01

    Through content and textual analysis of "Seventeen" magazine from 1951 to 1991, the emergence and transformation of environmental discourse are explored to show how the progressive impetus of a popular social movement is redefined in an adolescent magazine to create mythologies of consumption. (SLD)

  10. Critique of the Schema Concept.

    ERIC Educational Resources Information Center

    Dahlin, Bo

    2001-01-01

    Discusses the concept of schema and the role this concept plays in educational practice. Traces the historical development of the concept and how it came to be taken for granted that schemata exist. Suggests a return to a more phenomenological approach to learning and knowledge formation. (SLD)

  11. Priming and Constraints It Places on Theories of Memory and Retrieval.

    ERIC Educational Resources Information Center

    McNamara, Timothy P.

    1992-01-01

    Results of investigations into associative priming are summarized and the relative strengths of spreading activation and nonspreading activation theories of priming are assessed. The explanatory power of spreading-activation theories is at least as great as that of nonspreading-activation theories. (SLD)

  12. What To Measure? A New Look at the Concept of Creativity.

    ERIC Educational Resources Information Center

    Kaufmann, Geir

    2003-01-01

    Makes the case that the concept of creativity is too loosely defined and proposes a definition that clearly distinguishes creativity from intelligence. Makes a further distinction between proactive and reactive creativity and points out some shortcomings of existing tests of creativity. (SLD)

  13. Beginning Postsecondary Students Longitudinal Study: 1996-2001 (BPS:1996/2001) Methodology Report.

    ERIC Educational Resources Information Center

    Wine, Jennifer S.; Heuer, Ruth E.; Wheeless, Sara C.; Francis, Talbric L.; Franklin, Jeff W.; Dudley, Kristin M.

    2002-01-01

    Describes the procedures and results of the full-scale Implementation of the final followup interview with the Beginning Postsecondary Students Longitudinal Study 1996/2001. This study follows a cohort first interviewed in 1996 in their first year of postsecondary education. (SLD)

  14. Clinical Diagnosis among Diverse Populations: A Multicultural Perspective.

    ERIC Educational Resources Information Center

    Solomon, Alison

    1992-01-01

    Discusses four ways in which clinical diagnosis can be detrimental to minority clients: (1) cultural expressions of symptomatology; (2) unreliable research instruments; (3) clinician bias; and (4) institutional racism. Recommendations to avoid misdiagnosis begin with accurate assessment of a client's history and cultural background. (SLD)

  15. Orthographic Processing in Visual Word Identification.

    ERIC Educational Resources Information Center

    Humphreys, Glyn W.; And Others

    1990-01-01

    A series of 6 experiments involving 210 subjects from a college subject pool examined orthographic priming effects between briefly presented pairs of letter strings. A theory of othographic priming is presented, and the implications of the findings for understanding word recognition and reading are discussed. (SLD)

  16. Hypertension, End-Stage Renal Disease and Rehabilitation: A Look at Black Americans.

    ERIC Educational Resources Information Center

    Livingston, Ivor Lensworth; Ackah, Samuel

    1992-01-01

    Reviews the important relationship between end-stage renal disease (ESRD) and hypertension for African Americans; and considers issues associated with ESRD and the subsequent need for kidney transplants, including organ availability. Individual and societal implications of these diseases are discussed. (SLD)

  17. Specialty Selections of Jefferson Medical College Students: A Conjoint Analysis.

    ERIC Educational Resources Information Center

    Diamond, James J.; And Others

    1994-01-01

    A consumer research technique, conjoint analysis, was used to assess the relative importance of several factors in 104 fourth-year medical students' selection of specialty. Conjoint analysis appears to be a useful method for investigating the complex process of specialty selection. (SLD)

  18. Beyond Symbolic Processing: Expanding Horizons for Educational Psychology.

    ERIC Educational Resources Information Center

    Derry, Sharon J.

    1992-01-01

    The horizons are expanding for educational psychology as important questions are being raised about the extent and nature of the relationship between formal schooling and life experiences. A broadening of perspectives is required to incorporate cultural contexts and forces in which schooling takes part. (SLD)

  19. Globalization, Education, and Citizenship: Solidarity versus Markets?

    ERIC Educational Resources Information Center

    Torres, Carlos Alberto

    2002-01-01

    Suggests that globalization places limits on state autonomy and national sovereignty, affecting education in various ways. Educational policy and its contributions to citizenship, democracy, and multiculturalism will face unprecedented challenges if the logic of fear, exacerbated by the events of September 11, 2001 prevails. (Author/SLD)

  20. The Continuing Arrogation of the Curriculum Field: A Rejoinder to Pinar.

    ERIC Educational Resources Information Center

    Wraga, William G.

    1999-01-01

    Criticizes the response by William Pinar as not addressing points raised in Wraga's essay on reconceptualized curriculum studies. Pinar's vision of hopelessness for reforming the curriculum field continues the insulation of curriculum theorists from the complex problems of school practice. (SLD)

  1. The Credit Hour and Public Budgeting.

    ERIC Educational Resources Information Center

    Wellman, Jane V.

    2003-01-01

    Discusses the ways the credit hour has come to be used by public funding systems in higher education. The literature review shows that the credit hour has become a barrier to innovation and a way to create systemic inequities between institutions or sectors in resource allocation. (SLD)

  2. Montaigne's Uses of Classical Learning.

    ERIC Educational Resources Information Center

    Hall, Michael L.

    1997-01-01

    M. de Montaigne's essay "On the Education of Children" (1580) demonstrates the importance of examining classical authors to test understanding and develop judgment. Montaigne's method provides a way to study cultural heritage and to use the past to examine current issues. Implications for teaching today are discussed. (SLD)

  3. When (Not If) Evaluation Flexibility Is Desirable: Examples from the CPHPE Initiative.

    ERIC Educational Resources Information Center

    Hembroff, Larry; Perlstadt, Harry; Henry, Rebecca C.; Hogan, Andrew J.; Weissert, Carol S.; Bland, Carole J.; Harris, Dona L.; Knott, Jack H.; Starnaman, Sandra M.

    1999-01-01

    Two examples from the cluster evaluation of the W. K. Kellogg Foundation's Community Partnership for Health Professions Education illustrate why flexibility in evaluation design and activities is essential to collaborate with program directors and be responsive to program needs. (SLD)

  4. Variable Importance in Multivariate Group Comparisons.

    ERIC Educational Resources Information Center

    Huberty, Carl J.; Wisenbaker, Joseph M.

    1992-01-01

    Interpretations of relative variable importance in multivariate analysis of variance are discussed, with attention to (1) latent construct definition; (2) linear discriminant function scores; and (3) grouping variable effects. Two numerical ranking methods are proposed and compared by the bootstrap approach using two real data sets. (SLD)

  5. Four Bootstrap Confidence Intervals for the Binomial-Error Model.

    ERIC Educational Resources Information Center

    Lin, Miao-Hsiang; Hsiung, Chao A.

    1992-01-01

    Four bootstrap methods are identified for constructing confidence intervals for the binomial-error model. The extent to which similar results are obtained and the theoretical foundation of each method and its relevance and ranges of modeling the true score uncertainty are discussed. (SLD)

  6. Nonparametric Regression and the Parametric Bootstrap for Local Dependence Assessment.

    ERIC Educational Resources Information Center

    Habing, Brian

    2001-01-01

    Discusses ideas underlying nonparametric regression and the parametric bootstrap with an overview of their application to item response theory and the assessment of local dependence. Illustrates the use of the method in assessing local dependence that varies with examinee trait levels. (SLD)

  7. A Polymorphism in Mitochondrial DNA Associated with IQ?

    ERIC Educational Resources Information Center

    Skuder, Patricia; And Others

    1995-01-01

    Of 100 DNA markers examined in an allelic association study, only 1 showed a replicated association with IQ in samples totaling 107 children. How the gene marked by the particular restriction fragment length polymorphism was tracked and its mitochondrial origin identified is described. (SLD)

  8. Domestic Violence and Children: Analysis and Recommendations.

    ERIC Educational Resources Information Center

    Carter, Lucy Salcido; Weithorn, Lois A.; Behrman, Richard E.

    1999-01-01

    Summarizes current knowledge about the prevalence and effects of childhood exposure to domestic violence. Describes responses to this problem by the services systems with which children exposed to violence have contact and explores what is known about how well these responses work. (Contains 97 references.) (SLD)

  9. The International Provision of Higher Education: Do Universities Need GATS?

    ERIC Educational Resources Information Center

    Barblan, Andris

    2002-01-01

    Discusses whether universities need the General Agreement on Trade in Services (GATS) of the World Trade Organization, and concludes that they do not at present. Many questions remain to be answered before GATS should be applied to trade in education services. (SLD)

  10. To Tell a New Story: Reinventing Narratives of Culture, Identity, and Education.

    ERIC Educational Resources Information Center

    Florio-Ruane, Susan

    1997-01-01

    Reflects on stories educators tell about culture, identity, and education. If stories of self are to help educators reform institutions or build new communities, they must be reinvented to embrace others rather than to defend against contact with others. (SLD)

  11. Conducting Ethical Evaluations with Disadvantaged and Minority Target Groups.

    ERIC Educational Resources Information Center

    English, Brian

    1997-01-01

    This paper examines issues involved in conducting evaluations when participation by the target groups, typically minorities and disadvantaged groups, may put them in jeopardy. Argues that participation by target groups as cooperative partners throughout the evaluation is a way of addressing this dilemma. (SLD)

  12. The Role of the School in Children's Out-of-School Time.

    ERIC Educational Resources Information Center

    Dryfoos, Joy G.

    1999-01-01

    Reports the prevalence of school-based after-school programs and discusses extracurricular activities, child care, extended-day programs, enrichment programs, and efforts to make the schools community hubs. Outlines implementation challenges to program expansion: governance, space, program quality, funding, and accountability. (SLD)

  13. Stimulus Configuration, Classical Conditioning, and Hippocampal Function.

    ERIC Educational Resources Information Center

    Schmajuk, Nestor A.; DiCarlo, James J.

    1991-01-01

    The participation of the hippocampus in classical conditioning is described in terms of a multilayer network portraying stimulus configuration. A model of hippocampal function is presented, and computer simulations are used to study neural activity in the various brain areas mapped according to the model. (SLD)

  14. A Structural Modeling Approach to a Multilevel Random Coefficients Model.

    ERIC Educational Resources Information Center

    Rovine, Michael J.; Molenaar, Peter C. M.

    2000-01-01

    Presents a method for estimating the random coefficients model using covariance structure modeling and allowing one to estimate both fixed and random effects. The method is applied to real and simulated data, including marriage data from J. Belsky and M. Rovine (1990). (SLD)

  15. Why Did You Kill Our Hero?

    ERIC Educational Resources Information Center

    Loeb, George David

    1992-01-01

    Describes the reactions of a fourth grade class in Oklahoma City (Oklahoma) to the death through racial violence of their hero, a sailor with whom they had corresponded during the Persian Gulf War. The intended lesson in patriotism became a lesson in racism and violence. (SLD)

  16. Caribbean Music.

    ERIC Educational Resources Information Center

    Dean, Kris

    1991-01-01

    The Caribbean is a rich breeding ground for African-derived music. A synopsis is given of the music of the following countries and styles: (1) Jamaica; (2) Trinidad and Tobago; (3) Calypso; (4) steel pan; (5) Haiti; (6) Dominican Republic; (7) Cuba; (8) Puerto Rico; and (9) other islands. (SLD)

  17. Mixed Media: A Roundup of New Microform and Electronic Products.

    ERIC Educational Resources Information Center

    Carter, Christina E.

    1996-01-01

    Introduces two microfilm collections, one on the Indian Wars of the 19th century and one on records of the Southern Christian Leadership Conference, and four CD-ROM references focusing on Amnesty International, multicultural America, Latin American studies, and North American Indians. (SLD)

  18. Illusory Conjunctions: Does Inattention Really Matter?

    ERIC Educational Resources Information Center

    Navon, David; Ehrlich, Baruch

    1995-01-01

    Results of a study with 48 Israeli college students cast doubt on feature integration theory. Subjects searching for a probe in an array of three stimuli in two attention conditions, attention being manipulated by a dual-task requirement, made more conjunction errors than feature errors. (SLD)

  19. Listen to the Practitioner.

    ERIC Educational Resources Information Center

    Cook, Ann

    1992-01-01

    Overcoming the following obstacles will set the stage for meaningful school reform: (1) asking the wrong questions; (2) inadequate teacher preparation for reform; (3) opinions of "friendly" critics and inadequate advocates; (4) contempt for practitioners working directly with children; and (5) the criteria used to judge success. (SLD)

  20. Comparing State SAT Scores: Problems, Biases, and Corrections.

    ERIC Educational Resources Information Center

    Gohmann, Stephen F.

    1988-01-01

    One method to correct for selection bias in comparing Scholastic Aptitude Test (SAT) scores among states is presented, which is a modification of J. J. Heckman's Selection Bias Correction (1976, 1979). Empirical results suggest that sample selection bias is present in SAT score regressions. (SLD)

  1. Construct Validity of Neuropsychological Tests in Schizophrenia.

    ERIC Educational Resources Information Center

    Allen, Daniel N.; Aldarondo, Felito; Goldstein, Gerald; Huegel, Stephen G.; Gilbertson, Mark; van Kammen, Daniel P.

    1998-01-01

    The construct validity of neuropsychological tests in patients with schizophrenia was studied with 39 patients who were evaluated with a battery of six tests assessing attention, memory, and abstract reasoning abilities. Results support the construct validity of the neuropsychological tests in patients with schizophrenia. (SLD)

  2. The Motive--Strategy Congruence Model Revisited.

    ERIC Educational Resources Information Center

    Watkins, David; Hattie, John

    1992-01-01

    Research with 1,266 Australian secondary school students supports 2 propositions critical to the motive-strategy congruence model of J. B. Biggs (1985). Students tend to use learning strategies congruent with motivation for learning, and congruent motive-strategy combinations are associated with higher average school grades. (SLD)

  3. Literacy as Commodity: Redistributing the Goods.

    ERIC Educational Resources Information Center

    Elsasser, Nan; Irvine, Patricia

    1992-01-01

    A rationale is presented for educational change and the strategies to achieve it. The model of speech communities of Dell Hymes is used to show how language differences are connected to social and economic disparities. Efforts to create new speech communities to overcome inequalities are discussed. (SLD)

  4. The World Is Waiting for the Sunrise: African Americans "yel Mundo Latino."

    ERIC Educational Resources Information Center

    Widener, Danny

    1998-01-01

    Traces the long and varied history of interaction and collective action by African Americans and Latinos, focusing on common culture and political cooperation. Outlines issues related to the continued cooperation of African Americans and Latinos, and common political projects. (SLD)

  5. Spencer Postdoc Fellowships Give Young Scholars "A Chance to Look at the Taller Mountains."

    ERIC Educational Resources Information Center

    Patrick, Cynthia L.

    1991-01-01

    Describes the postdoctoral fellowship program of the Spencer Foundation. Administered by the National Academy of Education, Spencer Fellowships (30 annually) enable young scholars to pursue educational research by giving them the equivalent of a year off from teaching. (SLD)

  6. Animal Housing: The Secret Life of Students' Pets Is Not Always a Walk in the Park.

    ERIC Educational Resources Information Center

    Hoover, Eric

    2003-01-01

    Animals owned by college students are particularly vulnerable to neglect, mistreatment, and abandonment, given the fact that pets are usually prohibited from college dorms and student apartments. Some students, however, persist in keeping pets on campus. (SLD)

  7. NNSA B-Roll: Second Line of Defense

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2010-05-21

    The NNSA Office of Second Line of Defense (SLD) works to prevent illicit trafficking in nuclear and radiological materials by securing international land borders, seaports and airports that may be used as smuggling routes for materials needed for a nuclear device or a radiological dispersal device.

  8. K-Fold Crossvalidation in Canonical Analysis.

    ERIC Educational Resources Information Center

    Liang, Kun-Hsia; And Others

    1995-01-01

    A computer-assisted, K-fold cross-validation technique is discussed in the framework of canonical correlation analysis of randomly generated data sets. Analysis results suggest that this technique can effectively reduce the contamination of canonical variates and canonical correlations by sample-specific variance components. (Author/SLD)

  9. Should Hate Be a Crime?

    ERIC Educational Resources Information Center

    Jacobs, James B.

    1993-01-01

    Explores issues surrounding hate crime legislation and prosecution, with emphasis on motivation and first amendment issues. Hate crime legislation attempts to import the civil rights model into criminal law, but the very existence of the hate crime label raises social and political stakes in intergroup crimes. (SLD)

  10. A Generalized Method of Image Analysis from an Intercorrelation Matrix which May Be Singular.

    ERIC Educational Resources Information Center

    Yanai, Haruo; Mukherjee, Bishwa Nath

    1987-01-01

    This generalized image analysis method is applicable to singular and non-singular correlation matrices (CMs). Using the orthogonal projector and a weaker generalized inverse matrix, image and anti-image covariance matrices can be derived from a singular CM. (SLD)

  11. The Deterministic Origins of Sexism.

    ERIC Educational Resources Information Center

    Perry, Melissa J.; Albee, George W.

    1998-01-01

    Discusses the physical, sexual, and psychological ramifications of biological determinism using examples from the global status of women's health, the continuation of female genital mutilation, and the history of sexist beliefs in psychology that serve a social control function of creating and defining women's psychopathology. (Author/SLD)

  12. The Tunneling Method for Global Optimization in Multidimensional Scaling.

    ERIC Educational Resources Information Center

    Groenen, Patrick J. F.; Heiser, Willem J.

    1996-01-01

    A tunneling method for global minimization in multidimensional scaling is introduced and adjusted for multidimensional scaling with general Minkowski distances. The method alternates a local search step with a tunneling step in which a different configuration is sought with the same STRESS implementation. (SLD)

  13. Systematic Thinking Fostered by Illustrations in Scientific Text.

    ERIC Educational Resources Information Center

    Mayer, Richard E.

    1989-01-01

    In two experiments, a total of 78 female college students, who were novices about automobile mechanics, read technical passages about vehicle braking systems with and without illustrations that were labeled or unlabeled. Results indicate that illustrations help readers focus attention and form mental models. (SLD)

  14. Effects of Remarriage Following Divorce on the Academic Achievement of Children.

    ERIC Educational Resources Information Center

    Jeynes, William H.

    1999-01-01

    Used data from the National Educational Longitudinal Survey to study the effects of remarriage following divorce on children's academic achievement. Results indicate that children from reconstituted families score no higher, and often lower than children of divorce from single-parent families. (SLD)

  15. A Review of Two Distance Learning Books [book review].

    ERIC Educational Resources Information Center

    Koszalka, Tiffany A.; Spector, J. Michael

    2003-01-01

    Reviews two books that are representative of the substantive books aimed at those who wish to design effective distance learning. Together these books provide a reasonably complete perspective on how to design effective distance learning. They have many strengths, and few weaknesses. (SLD)

  16. An Evaluation of the 1977 Canadian Firearms Legislation.

    ERIC Educational Resources Information Center

    Mauser, Gary A.; Holmes, Richard A.

    1992-01-01

    A pooled cross-section time series model is used to evaluate the effect of the 1977 Canadian firearms legislation on the provincial homicide rate between 1969 and 1989. Results agree with most studies that indicate no significant effect of this legislation on homicide rates. (SLD)

  17. Young Murderers.

    ERIC Educational Resources Information Center

    Garbarino, James

    1999-01-01

    Reflects on the moral world of children who have committed acts of lethal violence. Young killers do not see any positive alternatives at the moment of violence. When they kill, they are seeking justice--as they see it. Emphasizes the importance of adults stimulating the development of empathy and spirituality. (SLD)

  18. Home Is Where You Make It: Hmong Refugees in Georgia.

    ERIC Educational Resources Information Center

    Duchon, D. A.

    1997-01-01

    Studies the successful adaptation of Hmong refugees in the Atlanta (Georgia) area using a sample of 81 adults and 101 children. Findings highlight prevailing economic conditions, the strategies taken by local Hmong leadership, and a high rate of conversion to Christianity. (SLD)

  19. Introduction to the Special Issue.

    ERIC Educational Resources Information Center

    Petrosino, Anthony

    2003-01-01

    Introduces the articles of this special issue focusing on randomized field trials in criminology. In spite of the overall lack of randomized field trials in criminology, some agencies and individuals are able to mount an impressive number of field trials, and these articles focus on their experiences. (SLD)

  20. Respecting the Evidence: The Achievement Crisis Remains Real.

    ERIC Educational Resources Information Center

    Stedman, Lawrence C.

    1996-01-01

    In their arguments that there is actually no crisis in American education and that students are achieving more than previous generations, David Berliner and Bruce Biddle have ignored or dismissed extensive data on student achievement that demonstrate the failings of the American system. (SLD)

  1. The GTA Mentoring Program: An Interdisciplinary Approach to Developing Future Faculty as Teacher-Scholars.

    ERIC Educational Resources Information Center

    Gaia, A. Celeste; Corts, Daniel P.; Tatum, Holly E.; Allen, Jan

    2003-01-01

    Describes an interdisciplinary mentoring program for graduate teaching assistance, the Graduate Teaching Assistant (GTA) program. Outlines the vision and structure of the program and highlights its many benefits, which include the development of personal and professional relationships. (SLD)

  2. State Efforts to Reform Schools: Treading between a Regulatory Swamp and an English Garden.

    ERIC Educational Resources Information Center

    Timar, Thomas B.; Kirp, David L.

    1988-01-01

    The educational reform strategies of Texas, California, and South Carolina are examined as they relate to reform outcomes. The current effort toward educational excellence must shift its focus from regulation and compliance monitoring to mobilization of institutional capacity. (SLD)

  3. Multiple Imputation for Multivariate Missing-Data Problems: A Data Analyst's Perspective.

    ERIC Educational Resources Information Center

    Schafer, Joseph L.; Olsen, Maren K.

    1998-01-01

    The key ideas of multiple imputation for multivariate missing data problems are reviewed. Software programs available for this analysis are described, and their use is illustrated with data from the Adolescent Alcohol Prevention Trial (W. Hansen and J. Graham, 1991). (SLD)

  4. A Short-Form Measure of Dentists' Job Satisfaction.

    ERIC Educational Resources Information Center

    Rabiner, Donna J.; And Others

    1994-01-01

    A 14-item instrument, the Dentist Satisfaction Survey-14, a form of a previously validated instrument, is described. Use with 522 dentists, and 29 in a follow-up, indicates that the short form is a parsimonious tool for general evaluation of dentists' job satisfaction. (SLD)

  5. Global Optimality of the Successive Maxbet Algorithm.

    ERIC Educational Resources Information Center

    Hanafi, Mohamed; ten Berge, Jos M. F.

    2003-01-01

    It is known that the Maxbet algorithm, which is an alternative to the method of generalized canonical correlation analysis and Procrustes analysis, may converge to local maxima. Discusses an eigenvalue criterion that is sufficient, but not necessary, for global optimality of the successive Maxbet algorithm. (SLD)

  6. Fighting Fragmentation: Coordination of Services for Children and Families.

    ERIC Educational Resources Information Center

    Soler, Mark; Shauffer, Carole

    1993-01-01

    Discusses efforts to coordinate services (mental health services in particular) for children and families, and reports initial findings of research by the Youth Law Center to identify specific characteristics of effective coordination programs. Sixteen characteristics of effective coordinated service programs have been identified. (SLD)

  7. Teaching about Domestic Violence: Strategies for Empowerment.

    ERIC Educational Resources Information Center

    Gardner, Saundra

    1993-01-01

    Offers the author's experiences in teaching a college-level domestic violence sociology course, presenting specific strategies and a description of the syllabus. The course presents a feminist analysis of domestic violence and examines how the patriarchal structure and ideology of society create and perpetuate violence. (SLD)

  8. Objective Measurement of Subjective Well-Being.

    ERIC Educational Resources Information Center

    Hahn, Elizabeth A.

    2000-01-01

    Demonstrates the usefulness of the Rasch model in evaluating the cross cultural equivalence of health-related quality of life instruments (HRQOL). Results from 195 U.S. cancer patients and 118 Austrian cancer patients identity biased items, providing a better estimate of each cultural group's HRQOL. (SLD)

  9. Environmental and Ethical Aspects of International Migration.

    ERIC Educational Resources Information Center

    Abernethy, Virginia

    1996-01-01

    Well-intentioned U.S. immigration policy has two ill effects in that it encourages the belief that emigration can relieve overpopulation in third-world countries, maintaining high fertility rates, and it results in U.S. domestic population growth that threatens employment opportunities and the environment. (SLD)

  10. A Componential IRT Model for Guilt.

    ERIC Educational Resources Information Center

    Smits, Dirk J. M.; De Boeck, Paul

    2003-01-01

    Studied the process structure of guilt with an adaptation of the Model with Internal Restrictions on Item Difficulty (R. Butter and others, 1998) administered to 270 high school students. Findings show that this kind of modeling is appropriate to investigate the structure of other emotions. (SLD)

  11. Giftedness and School: New Issues and Challenges.

    ERIC Educational Resources Information Center

    Cropley, Arthur J., Ed.

    1993-01-01

    Seven chapters focus in giftedness in education and the role of creativity. A second major issue is the recognition that not all groups are equally well served by provisions for the gifted. The emphasis is on intellectual giftedness, reflecting the focus of most school systems. (SLD)

  12. The TIMSS Videotape Study.

    ERIC Educational Resources Information Center

    Stigler, James W.; Hiebert, James

    1998-01-01

    As part of the Third International Mathematics and Science Study (TIMSS), videotapes of classroom instruction were collected from 231 eighth-grade mathematics classrooms in Germany, the United States, and Japan. Findings suggest that written reports about teaching disseminated to teachers may have little effect on classroom practices. (SLD)

  13. Priority Setting in Government: Beyond the Magic Bullet.

    ERIC Educational Resources Information Center

    Bosin, Morris Robert

    1992-01-01

    Priority setting is examined from the perspective of planning practitioners operating in a major federal regulatory agency. Causes of ambivalence in setting priorities are considered, and ways to reduce ambivalence are suggested. Three models are proposed for setting priorities in the public sector. (SLD)

  14. Overview of State Legislative and Judicial Responses.

    ERIC Educational Resources Information Center

    Larson, Carol S.

    1991-01-01

    Reviews recent actions by state legislatures and courts in response to the problems of drug-exposed newborns. Also discusses civil and criminal court decisions regarding women who use drugs during pregnancy. State policy responses cannot be developed without a detailed assessment of the state's resources. (SLD)

  15. Dinosaurs or Dynamos? The Future of Campuses.

    ERIC Educational Resources Information Center

    Coor, Lattie

    2000-01-01

    Describes approaches Arizona State University is taking to ensure that the campus remains an effective educational instrument in the future. Making the "engaged institution" an integral part of metropolitan Phoenix is a priority that can be implemented through new types of partnerships with the community. (SLD)

  16. 2.5-Gb/s hybridly-integrated tunable external cavity laser using a superluminescent diode and a polymer Bragg reflector.

    PubMed

    Yoon, Ki-Hong; Oh, Su Hwan; Kim, Ki Soo; Kwon, O-Kyun; Oh, Dae Kon; Noh, Young-Ouk; Lee, Hyung-Jong

    2010-03-15

    We presented a hybridly-integrated tunable external cavity laser with 0.8 nm mode spacing 16 channels operating in the direct modulation of 2.5-Gbps for a low-cost source of a WDM-PON system. The tunable laser was fabricated by using a superluminescent diode (SLD) and a polymer Bragg reflector. The maximum output power and the power slope efficiency of the tunable laser were 10.3 mW and 0.132 mW/mA, respectively, at the SLD current of 100 mA and the temperature of 25 degrees C. The directly-modulated tunable laser successfully provided 2.5-Gbps transmissions through 20-km standard single mode fiber. The power penalty of the tunable laser was less than 0.8 dB for 16 channels after a 20-km transmission. The power penalty variation was less than 1.4 dB during the blue-shifted wavelength tuning.

  17. Explicit formula for the Holevo bound for two-parameter qubit-state estimation problem

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Suzuki, Jun, E-mail: junsuzuki@uec.ac.jp

    The main contribution of this paper is to derive an explicit expression for the fundamental precision bound, the Holevo bound, for estimating any two-parameter family of qubit mixed-states in terms of quantum versions of Fisher information. The obtained formula depends solely on the symmetric logarithmic derivative (SLD), the right logarithmic derivative (RLD) Fisher information, and a given weight matrix. This result immediately provides necessary and sufficient conditions for the following two important classes of quantum statistical models; the Holevo bound coincides with the SLD Cramér-Rao bound and it does with the RLD Cramér-Rao bound. One of the important results ofmore » this paper is that a general model other than these two special cases exhibits an unexpected property: the structure of the Holevo bound changes smoothly when the weight matrix varies. In particular, it always coincides with the RLD Cramér-Rao bound for a certain choice of the weight matrix. Several examples illustrate these findings.« less

  18. GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication.

    PubMed

    Joshi, Kiranmai; Shah, Varun Jayeshkumar; Maddika, Subbareddy

    2016-12-01

    In eukaryotes, proper loading and activation of MCM helicase at chromosomal origins plays a central role in DNA replication. Activation of MCM helicase requires its association with CDC45-GINS complex, but the mechanism of how this complex activates MCM helicase is poorly understood. Here we identified SIK1 (salt-inducible kinase 1), an AMPK related protein kinase, as a molecular link that connects GINS complex with MCM helicase activity. We demonstrated that Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase. Depletion of SIK1 leads to defective DNA replication. Further, we showed that SIK1 phosphorylates MCM2 at five conserved residues at its N-terminus, which is essential for the activation of MCM helicase. Collectively, our results suggest SIK1 as a novel integral component of CMG replicative helicase during eukaryotic DNA replication. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Structure of single-supported DMPC lipid bilayer membranes as a function of hydration level studied by neutron reflectivity and Atomic Force Microscopy

    NASA Astrophysics Data System (ADS)

    Miskowiec, A.; Schnase, P.; Bai, M.; Taub, H.; Hansen, F. Y.; Dubey, M.; Singh, S.; Majewski, J.

    2012-02-01

    We have recently been investigating the diffusion of water on single-supported DMPC lipid bilayer membranes at different levels of hydration, using high-resolution quasielastic neutron scattering (QNS). To aid in the interpretation of these QNS studies, we have conducted neutron reflectivity (NR) measurements on SPEAR at LANSCE to characterize the structure of similarly prepared samples. Protonated DMPC membranes were deposited onto SiO2-coated Si(100) substrates and characterized by Atomic Force Microscopy (AFM) at different levels of hydration. We find reasonable agreement between the membrane thickness determined by NR and AFM at room temperature. We also find consistency between the scattering length density (SLD) profile in the vicinity of the upper leaflet of the supported DMPC membrane and that found in a molecular dynamics simulation of a freestanding membrane at 303 K. However, the fit to the reflectivity curve can be improved by modifying the SLD profile near the leaflet closest to the SiO2 surface.

  20. Anti-Stokes effect CCD camera and SLD based optical coherence tomography for full-field imaging in the 1550nm region

    NASA Astrophysics Data System (ADS)

    Kredzinski, Lukasz; Connelly, Michael J.

    2012-06-01

    Full-field Optical coherence tomography is an en-face interferometric imaging technology capable of carrying out high resolution cross-sectional imaging of the internal microstructure of an examined specimen in a non-invasive manner. The presented system is based on competitively priced optical components available at the main optical communications band located in the 1550 nm region. It consists of a superluminescent diode and an anti-stokes imaging device. The single mode fibre coupled SLD was connected to a multi-mode fibre inserted into a mode scrambler to obtain spatially incoherent illumination, suitable for OCT wide-field modality in terms of crosstalk suppression and image enhancement. This relatively inexpensive system with moderate resolution of approximately 24um x 12um (axial x lateral) was constructed to perform a 3D cross sectional imaging of a human tooth. To our knowledge this is the first 1550 nm full-field OCT system reported.

  1. Engineering Veterinary Education: A Clarion Call for Reform in Veterinary Education--Let's Do It!

    ERIC Educational Resources Information Center

    Radostits, Otto M.

    2003-01-01

    Supports an engineering model of tracking programs in veterinary medical education and suggests that undergraduate student quotas need to be considered in order to educate a sufficient number of new veterinary graduates in the different fields needed by society. (SLD)

  2. Financial Impact of Divorce on Children and Their Families.

    ERIC Educational Resources Information Center

    Teachman, Jay D.; Paasch, Kathleen M.

    1994-01-01

    Examines the financial impact of divorce on children and their families. The preponderance of evidence suggests that women and children experience substantial declines after divorce whereas the relative income of divorced men remains stable or increases. The impact of public assistance is also considered. (SLD)

  3. Egalitarian Fiction and Collective Fraud.

    ERIC Educational Resources Information Center

    Gottfredson, Linda S.

    1994-01-01

    Social science today condones and perpetuates the egalitarian fiction that racial and ethnic groups never differ in average developed intelligence (general mental ability). Enforcement of this lie and avoidance of real research into these issues is aiding bigots more than the truth would and is degrading intellectual integrity. (SLD)

  4. Foreword to "Intelligence and Social Policy."

    ERIC Educational Resources Information Center

    Gottfredson, Linda S.

    1997-01-01

    This special issue bridges inquiry on intelligence and scholarship on social policy by exploring the constraints that differences in intelligence may impose in fashioning effective social policy. The authors discuss a range of behaviors, but focus primarily on the noneducational outcomes of crime, employment, poverty, and health. (SLD)

  5. Intergenerational Patterns of Values and Autonomy Expectations in Cultures of Relatedness and Separatedness.

    ERIC Educational Resources Information Center

    Stewart, Sunita Mahtani; Bond, Michael Harris; Deeds, Osvelia; Chung, Siu Fung

    1999-01-01

    Investigated value priorities and autonomy expectations in 59 pairs of Caucasian and 66 pairs of Asian teenagers and their mothers in Hong Kong. Findings support models that predict persistent family interdependence despite adoption of many individualist values in modernizing collectivist cultures. (SLD)

  6. 1999 Customer Satisfaction Survey Report: How Do We Measure Up?

    ERIC Educational Resources Information Center

    Salvucci, Sameena; Parker, Albert C. E.; Cash, R. William; Thurgood, Lori

    2001-01-01

    Summarizes results of a 1999 survey regarding the satisfaction of various groups with publications, databases, and services of the National Center for Education Statistics. Groups studied were federal, state, and local policymakers; academic researchers; and journalists. Compared 1999 results with 1997 results. (Author/SLD)

  7. Prior Conceptual Knowledge and Textbook Search.

    ERIC Educational Resources Information Center

    Byrnes, James P.; Guthrie, John T.

    1992-01-01

    The role of a subject's conceptual knowledge in the procedural task of searching a text for information was studied for 51 college undergraduates in 2 experiments involving knowledge of anatomy. Students with more anatomical information were able to search a text more quickly. Educational implications are discussed. (SLD)

  8. Robust Mean and Covariance Structure Analysis through Iteratively Reweighted Least Squares.

    ERIC Educational Resources Information Center

    Yuan, Ke-Hai; Bentler, Peter M.

    2000-01-01

    Adapts robust schemes to mean and covariance structures, providing an iteratively reweighted least squares approach to robust structural equation modeling. Each case is weighted according to its distance, based on first and second order moments. Test statistics and standard error estimators are given. (SLD)

  9. Maximum Likelihood Estimation of Nonlinear Structural Equation Models.

    ERIC Educational Resources Information Center

    Lee, Sik-Yum; Zhu, Hong-Tu

    2002-01-01

    Developed an EM type algorithm for maximum likelihood estimation of a general nonlinear structural equation model in which the E-step is completed by a Metropolis-Hastings algorithm. Illustrated the methodology with results from a simulation study and two real examples using data from previous studies. (SLD)

  10. Life Imitates Pokemon: The Virtues and Necessities of Technology-Based Peer Education in Today's Schools.

    ERIC Educational Resources Information Center

    Bloomfield, David

    1999-01-01

    As the Pokemon game craze illustrates, the combination of peer education and technology makes for powerful educational experiences. Educators need to accept technology-based peer education as a help rather than a hindrance to improve educational outcomes for students. (SLD)

  11. Second-Grade Journeys on the Underground Railroad.

    ERIC Educational Resources Information Center

    Crump-Stenberg, Linda; Beilke, Patricia F.

    1999-01-01

    Describes a curriculum used in a second grade classroom to expose the predominantly white students to the culture and experiences of African Americans through a study of slavery and the Underground Railroad. Includes a bibliography of African folk tales and literature related to the African American experience. (SLD)

  12. Cognitive Dissonance Reduction as Constraint Satisfaction.

    ERIC Educational Resources Information Center

    Shultz, Thomas R.; Lepper, Mark R.

    1996-01-01

    It is argued that the reduction of cognitive dissonance can be viewed as a constraint satisfaction problem, and a computational model of the process of consonance seeking is proposed. Simulations from this model matched psychological findings from the insufficient justification and free-choice paradigms of cognitive dissonance theory. (SLD)

  13. Individual Differences in General Intelligence Correlate with Brain Function during Nonreasoning Tasks.

    ERIC Educational Resources Information Center

    Haier, Richard J.; White, Nathan S.; Alkire, Michael T.

    2003-01-01

    Administered Raven's Advanced Progressive Matrices to 22 adults and measured cerebral glucose activity as subjects viewed videos on 2 occasions. Data provide evidence that individual differences in intelligence correlate with brain function even when the brain is engaged in non-reasoning tasks. (SLD)

  14. Faculty Involvement in Administration of Schools.

    ERIC Educational Resources Information Center

    Ogletree, Earl J.; Schmidt, Linda J.

    1992-01-01

    Contrasts the faculty-led administration of the Waldorf Schools founded by R. Steiner with the administration by local school councils established in the Chicago (Illinois) Public Schools through the School Reform Act. In Chicago, morale and status of teachers can be improved by increasing their administrative partnership. (SLD)

  15. Hallmarks of a Successful CBO.

    ERIC Educational Resources Information Center

    Ginsburg, Sigmund G.

    2003-01-01

    Describes the attributes and actions that underlie the success of a chief business officer, drawing on the experiences of a chief business and chief financial officer at four types of institutions, including a museum, a small independent college, a large state university, and a medium-sized independent university. (SLD)

  16. Missing from Action: Where Are the Black Female School Superintendents?

    ERIC Educational Resources Information Center

    Alston, Judy A.

    2000-01-01

    Examines the lack of literature on black women in leadership positions, especially in education, and offers some suggestions to help fill the void of black women in the role of superintendent, assuring that black women seek the superintendency, are hired, and are retained. (SLD)

  17. The "Star Trek" Phenomenon: Towards a Typology of Curricula in Information Management.

    ERIC Educational Resources Information Center

    Rowley, Jennifer; Slack, Frances

    2000-01-01

    Uses the metaphor of the Starship Enterprise to elucidate the nature of roles in information management. The spaceship metaphor is a framework to support the identification of roles of pilot (end user), maintenance engineer (information intermediary), and designer (information systems professional). (SLD)

  18. Curriculum as a Moral Educator.

    ERIC Educational Resources Information Center

    Wynne, Edward A.; Ryan, Kevin

    1993-01-01

    Explores issues of curriculum as a moral educator, examining moral values conveyed by the hidden curriculum. Greater emphasis on moral education and character formation is a rediscovery of curriculum's core intention. Teachers can find their most potent instrument for moral education in the form and substance of the curriculum. (SLD)

  19. There's No Racial Justice without Economic Justice: Shortcomings of Clinton's Race Initiative Report.

    ERIC Educational Resources Information Center

    Dreier, Peter

    1998-01-01

    The widening disparity between wealth and poverty is the major obstacle to racial conciliation in the United States. Organized labor is the most important vehicle for challenging the widening gap between rich and poor to work for racial and economic justice. (SLD)

  20. JFK in Blackface: Spike Lee's "Malcolm X."

    ERIC Educational Resources Information Center

    Walker, Clarence E.

    1993-01-01

    Discusses the failure of filmmaker Spike Lee to grapple with the real politics of Malcolm X before and after he left the Nation of Islam. Acknowledging the complexity of the man and his context would avoid creating a mythical figure similar to Oliver Stone's movie "JFK." (SLD)

  1. Improving Service through Effective Practice Reviews.

    ERIC Educational Resources Information Center

    Mangano, Michael

    1991-01-01

    Effective practice reviews (EPRs) are described as used in evaluation studies for the Office of Evaluation and Inspections, a component of the U.S. Department of Health and Human Services. Examples are given of EPRs in addressing new problems, structuring and improving federal programs, and decreasing costs. (SLD)

  2. Reflections of a Former Oakland Public School Parent.

    ERIC Educational Resources Information Center

    Abron, JoNina M.

    1997-01-01

    Shares the perspectives of a black parent, herself a teacher at a school founded by the Black Panthers, whose daughter was educated in the public schools of Oakland (California) and Kalamazoo (Michigan) between 1986 and 1996. Many negative experiences, some centered around language, are described. (SLD)

  3. The African American Public Policy Update.

    ERIC Educational Resources Information Center

    McAlpine, Robert; And Others

    1992-01-01

    Reviews actions of the 102nd Congress of particular interest to African Americans, including the (1) Domestic Marshall Plan House Resolution; (2) Unemployment Benefits extension; (3) Job Training Partnership Act; (4) Workplace Fairness Act; (5) Family and Medical Leave Act; and (6) Civil Rights Act of 1991. (SLD)

  4. Prevalence and Effects of Child Exposure to Domestic Violence.

    ERIC Educational Resources Information Center

    Fantuzzo, John W.; Mohr, Wanda K.

    1999-01-01

    Discusses the limitations of current databases documenting the prevalence and effects of child exposure to domestic violence and describes a model for the collection of reliable and valid prevalence data, the Spousal Assault Replication Program, which uses data collected by the police and university researchers. (SLD)

  5. "A History of Us." An Excerpt.

    ERIC Educational Resources Information Center

    Hakim, Joy; And Others

    1993-01-01

    Introduces a new series of U.S. history textbooks geared to grade five (or grades four, five, and six). The 10-volume series, divided into short, manageable chapters, aims to make history come alive. An excerpt from Book 6 ("War, Terrible War") about the Civil War is presented. (SLD)

  6. Developing an Initial Physical Function Item Bank from Existing Sources.

    ERIC Educational Resources Information Center

    Bode, Rita K.; Cella, David; Lai, Jin-shei; Heinemann, Allen W.

    2003-01-01

    Illustrates incremental item banking using health-related quality of life data collected from two samples of patients receiving cancer treatment (n=1,755 and n=1,544). Results support findings from previous studies that have equated separate instruments by co-calibrating their items. (SLD)

  7. Penn Inventory for Posttraumatic Stress Disorder: Psychometric Properties.

    ERIC Educational Resources Information Center

    Hammarberg, Melvyn

    1992-01-01

    A three-phase study was conducted to develop and validate the Penn Inventory for Posttraumatic Stress Disorder (PTSD), a 26-item self-report measure. Results with 83 and 98 combat veterans and with 76 general population patients and disaster survivors support usefulness of the measure. (SLD)

  8. History and Current Status of Divorce in the United States.

    ERIC Educational Resources Information Center

    Furstenberg, Frank F., Jr.

    1994-01-01

    Explores the remarkable shift in marriage and divorce practices that has occurred in the last third of this century in the United States. Information is presented on trends in this country and other industrialized nations, and some reasons for these changes are explored. (SLD)

  9. Clarification to "Examining Rater Errors in the Assessment of Written Composition with a Many-Faceted Rasch Model."

    ERIC Educational Resources Information Center

    Englehard, George, Jr.

    1996-01-01

    Data presented in figure three of the article cited may be misleading in that the automatic scaling procedure used by the computer program that generated the histogram highlighted spikes that would look different with different histogram methods. (SLD)

  10. Physical Activity and Adolescent Female Psychological Development.

    ERIC Educational Resources Information Center

    Covey, Linda A.; Feltz, Deborah L.

    1991-01-01

    Relationships between self-reported past and present physical activity levels and self-image, sense of mastery, gender role identity, self-perceived physical ability, and self-perceived attractiveness were studied for 149 female high school sophomores, juniors, and seniors. Results are discussed in terms of adolescent emotional health. (SLD)

  11. ARMA-Based SEM When the Number of Time Points T Exceeds the Number of Cases N: Raw Data Maximum Likelihood.

    ERIC Educational Resources Information Center

    Hamaker, Ellen L.; Dolan, Conor V.; Molenaar, Peter C. M.

    2003-01-01

    Demonstrated, through simulation, that stationary autoregressive moving average (ARMA) models may be fitted readily when T>N, using normal theory raw maximum likelihood structural equation modeling. Also provides some illustrations based on real data. (SLD)

  12. A King over Egypt, Which Knew Not Joseph.

    ERIC Educational Resources Information Center

    Coffman, William E.

    1993-01-01

    Although it is true that today's education needs improvement, schools today are not all bad. The opinions of the following five experts, whose views are worth hearing are introduced: (1) Thomas Hopkins; (2) Ralph Tyler; (3) E. F. Lindquist; (4) Walter Cook; and (5) Harold Benjamin. (SLD)

  13. Estimating and Testing the Sources of Evoked Potentials in the Brain.

    ERIC Educational Resources Information Center

    Huizenga, Hilde M.; Molenaar, Peter C. M.

    1994-01-01

    The source of an event-related brain potential (ERP) is estimated from multivariate measures of ERP on the head under several mathematical and physical constraints on the parameters of the source model. Statistical aspects of estimation are discussed, and new tests are proposed. (SLD)

  14. Dynamic Factor Analysis of Nonstationary Multivariate Time Series.

    ERIC Educational Resources Information Center

    Molenaar, Peter C. M.; And Others

    1992-01-01

    The dynamic factor model proposed by P. C. Molenaar (1985) is exhibited, and a dynamic nonstationary factor model (DNFM) is constructed with latent factor series that have time-varying mean functions. The use of a DNFM is illustrated using data from a television viewing habits study. (SLD)

  15. Simultaneous Inference Using Finite Intersection Tests: A Better Mousetrap.

    ERIC Educational Resources Information Center

    Timm, Neil H.

    1995-01-01

    The finite intersection test (FIT) developed by P. K. Krishnaiah (1964, 1965) is discussed and compared with more familiar methods for simultaneous inference. How the FIT can be used to analyze differences among all means for both univariate and multivariate experimental designs is explained. (SLD)

  16. Project Success for the SLD Child, Curriculum Modification.

    ERIC Educational Resources Information Center

    Owens, Jean

    The curriculum modification guide, developed by project success (Nebraska) through a Title III grant for language disabled elementary level students, contains suggested activities and instructional materials to be used in units of art, health, mathematics, music, science, and social studies. Explained are program planning, criteria for selecting…

  17. Schools' Defense of Children in America at War.

    ERIC Educational Resources Information Center

    Pryor, Carolyn B.

    1992-01-01

    Examines effects of the Persian Gulf War on elementary school and secondary school students and school responses through focus groups and interviews with school personnel, a survey of 97 students, and a discussion with 4 Chaldean-American middle school girls. Diverse attitudes required varying school responses. (SLD)

  18. Using Multiattribute Utility Theory as a Priority-Setting Tool in Human Services Planning.

    ERIC Educational Resources Information Center

    Camasso, Michael J.; Dick, Janet

    1993-01-01

    The feasibility of applying multiattribute utility theory to the needs assessment and priority-setting activities of human services planning councils was studied in Essex County (New Jersey). Decision-making and information filtering processes are explored in the context of community planning. (SLD)

  19. 'Net Equity: A Report on Income and Internet Access.

    ERIC Educational Resources Information Center

    Moss, Mitchell; Mitra, Steve

    1998-01-01

    Examines the structure of the subscriber base formed under the current pricing policies of Internet providers and investigates how access to the Internet varies in communities with different demographic characteristics. Report is based on a survey from a national Internet service provided in 1997. (SLD)

  20. Simple and Hierarchical Models for Stochastic Test Misgrading.

    ERIC Educational Resources Information Center

    Wang, Jianjun

    1993-01-01

    Test misgrading is treated as a stochastic process. The expected number of misgradings, inter-occurrence time of misgradings, and waiting time for the "n"th misgrading are discussed based on a simple Poisson model and a hierarchical Beta-Poisson model. Examples of model construction are given. (SLD)

  1. A Dream Deferred: The Social and Legal Implications of Hate Crimes in the 1990s.

    ERIC Educational Resources Information Center

    Levin, Brian

    1993-01-01

    Examines legal and social implications of bias violence today and in the coming years. The most important legal development regarding hate crimes is the Supreme Court's "Wisconsin v. Mitchell" decision upholding the constitutionality of bias crime penalty enhancement laws. (SLD)

  2. Evaluating Personalized Risk Messages.

    ERIC Educational Resources Information Center

    Weinstein, Neil D.; And Others

    1992-01-01

    An experiment with 766 homeowners compared 3 strategies for delivering radon test results to homeowners. Small improvements in consumer satisfaction were found for personalized messages (a telephone call or personal letter) over a form letter. No detectable improvement was found in recall of advice or compliance for any strategy. (SLD)

  3. The Circulation of European Educational Theories and Practices: The Algerian Experience.

    ERIC Educational Resources Information Center

    Miliani, Mohamed

    1996-01-01

    Explores the historical development of education in modern Algeria, arguing that Algeria, despite interest in celebrating the national identity, is still characterized by the wholesale adoption of European educational theories, policies, and practices, even though these do not fit well with indigenous culture. (SLD)

  4. Warriors Don't Cry: A Searing Memoir of the Battle to Integrate Little Rock's Central High.

    ERIC Educational Resources Information Center

    Beals, Melba Pattillo

    1994-01-01

    Recounts experiences of the author as one of the black students who integrated Central High School in Little Rock (Arkansas) in 1957 and presents a retrospective as she looks back on her story and the civil rights movement. (SLD)

  5. The Demonstration of Short-Term Consolidation.

    ERIC Educational Resources Information Center

    Jolicoeur, Pierre; Dell'Acqua, Roberto

    1998-01-01

    Results of seven experiments involving 112 college students or staff using a dual-task approach provide evidence that encoding information into short-term memory involves a distinct process termed short-term consolidation (STC). Results suggest that STC has limited capacity and that it requires central processing mechanisms. (SLD)

  6. Development of Measurability and Importance Scales for the NATA Athletic Training Educational Competencies.

    ERIC Educational Resources Information Center

    Wolfe, Edward W.; Nogle, Sally

    2002-01-01

    Developed and validated an instrument designed to measure the perceived measurability and importance of the National Athletic Trainers' Association Athletic Training Educational Competencies. Data from 931 athletic trainers and sport medicine physicians support 6 constructs, each of which demonstrates high reliability. (SLD)

  7. Investigation of Mediational Processes Using Parallel Process Latent Growth Curve Modeling.

    ERIC Educational Resources Information Center

    Cheong, JeeWon; MacKinnon, David P.; Khoo, Siek Toon

    2003-01-01

    Investigated a method to evaluate mediational processes using latent growth curve modeling and tested it with empirical data from a longitudinal steroid use prevention program focusing on 1,506 high school football players over 4 years. Findings suggest the usefulness of the approach. (SLD)

  8. Was Euclid an Unnecessarily Sophisticated Psychologist?

    ERIC Educational Resources Information Center

    Arabie, Phipps

    1991-01-01

    The current state of multidimensional scaling using the city-block metric is reviewed, with attention to (1) substantive and theoretical issues; (2) recent algorithmic developments and their implications for analysis; (3) isometries with other metrics; (4) links to graph-theoretic models; and (5) prospects for future development. (SLD)

  9. It's Deja Vu All over Again: Using Multiple-Spell Discrete-Time Survival Analysis.

    ERIC Educational Resources Information Center

    Willett, John B.; Singer, Judith D.

    1995-01-01

    The multiple-spell discrete-time survival analysis method is introduced and illustrated using longitudinal data on exit from and reentry into the teaching profession. The method is applicable to many educational problems involving the sequential occurrence of disparate events or episodes. (SLD)

  10. The Psychology of Isolated and Confined Environments: Understanding Human Behavior in Antarctica.

    ERIC Educational Resources Information Center

    Palinkas, Lawrence A.

    2003-01-01

    Reviews lessons learned from research in Antarctica with relevance to understanding human behavior in other isolated and confined environments. Outlines four distinct characteristics of psychosocial adaptation to such environments and discusses some of the benefits for individuals seeking challenging experiences. (Contains references.) (SLD)

  11. Statement Verification: A Stochastic Model of Judgment and Response.

    ERIC Educational Resources Information Center

    Wallsten, Thomas S.; Gonzalez-Vallejo, Claudia

    1994-01-01

    A stochastic judgment model (SJM) is presented as a framework for addressing issues in statement verification and probability judgment. Results of 5 experiments with 264 undergraduates support the validity of the model and provide new information that is interpreted in terms of the SJM. (SLD)

  12. Black Women and Career Advancement: Preparing for the New Workplace.

    ERIC Educational Resources Information Center

    Shields, Leslie

    1992-01-01

    Discusses the status of black women, and examines what they need to do to strengthen their positions in the workplace. In the face of existing career obstacles, both individual initiatives such as securing training and finding mentors, and public policy initiatives are needed. (SLD)

  13. Caution--Praise Can Be Dangerous.

    ERIC Educational Resources Information Center

    Dweck, Carol S.

    1999-01-01

    Reviews research into the effects of praise on students. Suggests an approach that gets students to focus on their potential to learn, to value challenge, and to concentrate on effort and learning processes in the face of obstacles. This can all be done while holding students to rigorous standards. (SLD)

  14. Understanding Graduate Women's Reentry Experiences: Case Studies of Four Psychology Doctoral Students in a Midwestern University.

    ERIC Educational Resources Information Center

    Padula, Marjorie A.; Miller, Dana L.

    1999-01-01

    Studied the experiences of reentry women in psychology doctoral programs at a research university and illustrates the usefulness of the qualitative case study in exploring women's experiences. Case study research can be a powerful tool for feminist researchers. (SLD)

  15. Using Extreme Groups Strategy When Measures Are Not Normally Distributed.

    ERIC Educational Resources Information Center

    Fowler, Robert L.

    1992-01-01

    A Monte Carlo simulation explored how to optimize power in the extreme groups strategy when sampling from nonnormal distributions. Results show that the optimum percent for the extreme group selection was approximately the same for all population shapes, except the extremely platykurtic (uniform) distribution. (SLD)

  16. A Variable-Selection Heuristic for K-Means Clustering.

    ERIC Educational Resources Information Center

    Brusco, Michael J.; Cradit, J. Dennis

    2001-01-01

    Presents a variable selection heuristic for nonhierarchical (K-means) cluster analysis based on the adjusted Rand index for measuring cluster recovery. Subjected the heuristic to Monte Carlo testing across more than 2,200 datasets. Results indicate that the heuristic is extremely effective at eliminating masking variables. (SLD)

  17. Evaluation Capacity in K-12 School Counseling Programs.

    ERIC Educational Resources Information Center

    Trevisan, Michael S.

    2002-01-01

    Presents results of a literature review, organized the Milstein and Cotton evaluation capacity (B. Milstein and D. Cotton, 2000) framework, detailing and analyzing the contextual factors and system features that impact the evaluation capacity of school counseling programs. Discusses implications for evaluation in other settings. (SLD)

  18. Child Indicators: Immunization of Young Children.

    ERIC Educational Resources Information Center

    Lewit, Eugene M.; Mullahy, John

    1994-01-01

    Focuses on the immunization status of children aged 19 to 35 months. Recommended immunizations are described and contrasted with the actual status of immunization. In response to unacceptably low levels of immunization among very young children, the government is aiming at 90% immunization by the year 2000. (SLD)

  19. Categorical Variables in Multiple Regression: Some Cautions.

    ERIC Educational Resources Information Center

    O'Grady, Kevin E.; Medoff, Deborah R.

    1988-01-01

    Limitations of dummy coding and nonsense coding as methods of coding categorical variables for use as predictors in multiple regression analysis are discussed. The combination of these approaches often yields estimates and tests of significance that are not intended by researchers for inclusion in their models. (SLD)

  20. Demographic Paradoxes in the Los Angeles Voting Rights Case.

    ERIC Educational Resources Information Center

    Clark, William A. V.; Morrison, Peter A.

    1991-01-01

    How technical demographic analysis can inform and confuse judicial considerations of voting rights principles is illustrated in a review of a 1990 case brought against Los Angeles County (California). A postscripted article considers whether the court involved should rely on after-census estimates for redistricting. (SLD)

  1. Higher Education--The Flexible Employment Sector?

    ERIC Educational Resources Information Center

    Scott, Jill; Ridgley, Clare; Spurgeon, Peter

    2003-01-01

    Explored the extent to which policies and practices promoting work-life balance (family friendly policies) have been taken up within the English higher education sector. Responses from 50 higher education institutions show that flexible working practices are more widespread than the formal policies of institutions would suggest. (SLD)

  2. Estimation of Reliability Coefficients Using the Test Information Function and Its Modifications.

    ERIC Educational Resources Information Center

    Samejima, Fumiko

    1994-01-01

    The reliability coefficient is predicted from the test information function (TIF) or two modified TIF formulas and a specific trait distribution. Examples illustrate the variability of the reliability coefficient across different trait distributions, and results are compared with empirical reliability coefficients. (SLD)

  3. Comments on "Understanding Graduate Women's Reentry Experiences." Commentary.

    ERIC Educational Resources Information Center

    Lott, Bernice

    1999-01-01

    The case-study method used in "Understanding Graduate Women's Reentry Experiences" yielded personal information of considerable depth, but the conclusions drawn from the study are not all that different from those drawn from more quantitative investigations. Suggests that a multimethod approach is the best research strategy. (SLD)

  4. Jack Stenner: The Lexile King.

    ERIC Educational Resources Information Center

    Webster, Linda J.

    2000-01-01

    Traces the career of Jack Stenner. Stenner made the empirical discovery that observable readability could be entirely predicted from word familiarity and sentence length, and applied this "Lexile Framework"(R) to books and readers. Discusses the use of the Lexile Framework as a way to target specific readers. (SLD)

  5. Measurement Musings.

    ERIC Educational Resources Information Center

    Fisher, William P., Jr.; Choi, Ellie; Fisher, William P.; Stenner, A. Jackson; Horabin, Ivan; Wright, Benjamin D.

    1998-01-01

    Comments on measurement aspects are presented in discussions of (1) methodology and morality (W. P. Fisher); (2) Rasch measurement (E. Choi); (3) novel wisdom of the Rasch approach (W. P. Fisher); (4) development of construct definition and calibration (A. J. Stenner and I. Horabin); and (5) origin of dimensions (B. D. Wright). (SLD)

  6. Evaluating WIC.

    ERIC Educational Resources Information Center

    Germanis, Peter; Besharov, Douglas J.

    2000-01-01

    Describes the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and reviews and assesses research on its impact. Recommends policy reforms and randomized experiments to evaluate the program and any changes made to it. Weaknesses in research to date make the real impacts of WIC unclear. (Contains 79 references.) (SLD)

  7. African-American Sacred Music.

    ERIC Educational Resources Information Center

    Bailey, A. Peter

    1991-01-01

    The history of African-American sacred music is traced from the time of slavery to the present interest in gospel music. The religious music of African Americans is geared toward liberation themes. It is important that this music does not dilute its power through cross-over with other music forms. (SLD)

  8. Child Sacrifice: Black America's Price of Paying the Media Piper.

    ERIC Educational Resources Information Center

    Orange, Carolyn M.; George, Amiso M.

    2000-01-01

    Explores the sacrifice of African American children to the broadcast media and video games in terms of the players ("media pipers"), the messages ("piping"), and the consequences to children. Proposes some solutions for the problems associated with excessive television viewing and undesirable programming. (SLD)

  9. Teaching Evidence-Based Medicine: A Regional Dissemination Model.

    ERIC Educational Resources Information Center

    Leipzig, Rosanne M.; Wallace, Eleanor Z.; Smith, Lawrence G.; Sullivant, Jean; Dunn, Kathel; McGinn, Thomas

    2003-01-01

    Described and evaluated an interactive course designed to create a cadre of medical school faculty in New York who could integrate evidence-based medicine into their training programs. Findings for representatives of 30 internal medicine residency programs show the usefulness of the regional dissemination model used. (SLD)

  10. Proyecto Aurora: Building a Community of Women.

    ERIC Educational Resources Information Center

    Noya, Gladys R. Capella

    1997-01-01

    Describes the development of Proyecto Aurora, a program to develop and implement educational, support, and research programs to benefit low-income women in Puerto Rico. Portraits of some clients illustrate the rewards and challenges of working with this community and furthering their educational experiences and opportunities. (SLD)

  11. The Wechsler Memory Scale: A Review of Research.

    ERIC Educational Resources Information Center

    Ivison, David

    1990-01-01

    Research on the standardization, reliability, validity, factor structure, and subtests of the Wechsler Memory Scale (WMS) (1945) and its revised version (1987) is reviewed. Much research relating to the WMS appears to be relevant to the revised version. Use of the instrument in Australia is discussed. (SLD)

  12. The Magical Number Seven, Plus or Minus Two: Some Limits on Our Capacity for Processing Information.

    ERIC Educational Resources Information Center

    Miller, George A.

    1994-01-01

    Capacity limitations in absolute judgment tasks are discussed in relation to information theory. Information theory can provide a quantitative way of resolving questions about limitations on the amount of information we can receive and the process of recoding. (SLD)

  13. The Costs of an Enhanced Employee Assistance Program (EAP) Intervention.

    ERIC Educational Resources Information Center

    French, Michael T.; Dunlap, Laura J.; Zarkin, Gary A.; Karuntzos, Georgia T.

    1998-01-01

    This study estimates the economic costs of an enhanced Employee Assistance Program (EAP) intervention at a large midwestern EAP that serves 90 worksites. Results specify developmental and implementation costs and provide benchmark cost estimated for other EAPs that may be considering enhanced services. (SLD)

  14. Can Addiction-Related Self-Help/Mutual Aid Groups Lower Demand for Professional Substance Abuse Treatment?

    ERIC Educational Resources Information Center

    Humphreys, Keith

    1998-01-01

    Discusses the potential of self-help/mutual-aid groups as a way to reduce the demand for professional substance-abuse treatment and proposes a model that combines the two approaches for cost-effective and therapeutically effective networks of services. (SLD)

  15. The Impact of the Feminist Critique on Tests, Assessment, and Methodology.

    ERIC Educational Resources Information Center

    Lewin, Miriam; Wild, Cheryl L.

    1991-01-01

    Discusses early feminist efforts in psychological assessment, and reviews general issues related to feminist methodology. Successful impact and lack of impact of feminist criticism are illustrated by the revisions of the Strong Campbell Interest Inventory and the Minnesota Multiphasic Personality Inventory (1990), respectively. (SLD)

  16. Modeling Individual Differences in Unfolding Preference Data: A Restricted Latent Class Approach.

    ERIC Educational Resources Information Center

    Bockenholt, Ulf; Bockenholt, Ingo

    1990-01-01

    A latent-class scaling approach is presented for modeling paired comparison and "pick any/t" data obtained in preference studies. The utility of this approach is demonstrated through analysis of data from studies involving consumer preference and preference for political candidates. (SLD)

  17. Adaptation of Salvadoran Refugees in Montreal.

    ERIC Educational Resources Information Center

    Jacob, Andre

    1992-01-01

    Analyzes the situation of Salvadoran refugees of rural origin to Montreal (Canada), using life histories of 11 males and 11 females in Canada less than 5 years. This study of adaptation highlights the special needs of this population, particularly for information about social services and government programs. (SLD)

  18. Strategies for Educational Action To Meet Veterinary Medicine's Role in Biodefense and Public Health.

    ERIC Educational Resources Information Center

    Baker, John; Blackwell, Michael; Buss, Daryl; Eyre, Peter; Held, Joe R.; Ogilvie, Tim; Pappaioanou, Marguerite; Sawyer, Leigh

    2003-01-01

    Summarizes recommendations of a conference focused on how veterinary education needs to change to meet the challenges ahead related to biodefense and public health. Presents results of seven sections, each dealing with a major issue related to veterinary medical education. (SLD)

  19. Estimating the Classification Efficiency of a Test Battery.

    ERIC Educational Resources Information Center

    De Corte, Wilfried

    2000-01-01

    Shows how a theorem proven by H. Brogden (1951, 1959) can be used to estimate the allocation average (a predictor based classification of a test battery) assuming that the predictor intercorrelations and validities are known and that the predictor variables have a joint multivariate normal distribution. (SLD)

  20. Self-Assessment in Coursework Essays.

    ERIC Educational Resources Information Center

    Longhurst, Nigel; Norton, Lin S.

    1997-01-01

    Self-assessments of coursework essays were compared with tutor grades for 67 college students. Students could accurately assess their overall essay grades and could give an overall rank for deep processing, but when judging essays on individual criteria they were not so accurate when compared to tutor evaluations. (SLD)

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