Probabilistic Assessment of Fracture Progression in Composite Structures

NASA Technical Reports Server (NTRS)

Chamis, Christos C.; Minnetyan, Levon; Mauget, Bertrand; Huang, Dade; Addi, Frank

1999-01-01

This report describes methods and corresponding computer codes that are used to evaluate progressive damage and fracture and to perform probabilistic assessment in built-up composite structures. Structural response is assessed probabilistically, during progressive fracture. The effects of design variable uncertainties on structural fracture progression are quantified. The fast probability integrator (FPI) is used to assess the response scatter in the composite structure at damage initiation. The sensitivity of the damage response to design variables is computed. The methods are general purpose and are applicable to stitched and unstitched composites in all types of structures and fracture processes starting from damage initiation to unstable propagation and to global structure collapse. The methods are demonstrated for a polymer matrix composite stiffened panel subjected to pressure. The results indicated that composite constituent properties, fabrication parameters, and respective uncertainties have a significant effect on structural durability and reliability. Design implications with regard to damage progression, damage tolerance, and reliability of composite structures are examined.

Toward high-resolution computational design of helical membrane protein structure and function

PubMed Central

Barth, Patrick; Senes, Alessandro

2016-01-01

The computational design of α-helical membrane proteins is still in its infancy but has made important progress. De novo design has produced stable, specific and active minimalistic oligomeric systems. Computational re-engineering can improve stability and modulate the function of natural membrane proteins. Currently, the major hurdle for the field is not computational, but the experimental characterization of the designs. The emergence of new structural methods for membrane proteins will accelerate progress PMID:27273630

Toward high-resolution computational design of the structure and function of helical membrane proteins.

PubMed

Barth, Patrick; Senes, Alessandro

2016-06-07

The computational design of α-helical membrane proteins is still in its infancy but has already made great progress. De novo design allows stable, specific and active minimal oligomeric systems to be obtained. Computational reengineering can improve the stability and function of naturally occurring membrane proteins. Currently, the major hurdle for the field is the experimental characterization of the designs. The emergence of new structural methods for membrane proteins will accelerate progress.

Feeling bad about progress does not lead people want to change their health behaviour.

PubMed

Reynolds, James P; Webb, Thomas L; Benn, Yael; Chang, Betty P I; Sheeran, Paschal

2018-02-01

When do people decide to do something about problematic health behaviours? Theoretical models and pragmatic considerations suggest that people should take action when they feel bad about their progress - in other words, when they experience negative progress-related affect. However, the impact of progress-related affect on goal striving has rarely been investigated. Study 1 (N = 744) adopted a cross-sectional design and examined the extent to which measures of progress-related affect were correlated with intentions to take action. Study 2 (N = 409) investigated the impact of manipulating progress-related affect on intentions and behaviour in an experimental design. Study 1 found that, while engaging in health behaviours had the expected affective consequences (e.g. people felt bad when they were not eating healthily, exercising regularly or limiting their alcohol consumption), it was feeling good rather than bad about progress that was associated with stronger intentions. Study 2 replicated these findings. Participants induced to feel good about their eating behaviour had marginally stronger intentions to eat healthily than participants led to feel bad about their eating behaviour. The findings have implications for interventions designed to promote changes in health behaviour, as well as theoretical frameworks for understanding self-regulation.

Progress report No. 2, design of new pile area {open_quotes}G,{close_quotes} Project C-300, Atomic Energy Commission Directive HW-104

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowe, P.E.

1950-01-16

This document is the progress report for the design and development of Pile Area {open_quotes}G{close_quotes}, to cover the period June 1, 1949 to December 31, 1949. This project represents the major effort of the Reactor Division of the Design and Construction Divisions. It is being pursued with the aim of being able to incorporate the major project objectives in a finished pile design if that design is begun about January, 1951.

A progressive gradient moment nulling design technique.

PubMed

Pipe, J G; Chenevert, T L

1991-05-01

A method is presented for designing motion-compensated gradients in a progressive manner. The method is easily applicable to many types of waveforms, and can compensate for any order of motion. It can be implemented graphically or numerically. Underlying theory and examples of its application are provided.

Supply Chain Sustainability Analysis of Whole Algae Hydrothermal Liquefaction and Upgrading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pegallapati, Ambica Koushik; Dunn, Jennifer B.; Frank, Edward D.

2015-04-01

The Department of Energy's Bioenergy Technology Office (BETO) collaborates with a wide range of institutions towards the development and deployment of biofuels and bioproducts. To facilitate this effort, BETO and its partner national laboratories develop detailed techno-economic assessments (TEA) of biofuel production technologies as part of the development of design cases and state of technology (SOT) analyses. A design case is a TEA that outlines a target case for a particular biofuel pathway. It enables preliminary identification of data gaps and research and development needs and provides goals and targets against which technology progress is assessed. On the other hand,more » an SOT analysis assesses progress within and across relevant technology areas based on actual experimental results relative to technical targets and cost goals from design cases and includes technical, economic, and environmental criteria as available. (SOT) analyses. A design case is a TEA that outlines a target case for a particular biofuel pathway. It enables preliminary identification of data gaps and research and development needs and provides goals and targets against which technology progress is assessed. On the other hand, an SOT analysis assesses progress within and across relevant technology areas based on actual experimental results relative to technical targets and cost goals from design cases and includes technical, economic, and environmental criteria as available. (SOT) analyses. A design case is a TEA that outlines a target case for a particular biofuel pathway. It enables preliminary identification of data gaps and research and development needs and provides goals and targets against which technology progress is assessed. On the other hand, an SOT analysis assesses progress within and across relevant technology areas based on actual experimental results relative to technical targets and cost goals from design cases and includes technical, economic, and environmental criteria as available.« less

2016 Nebraska Higher Education Progress Report

ERIC Educational Resources Information Center

Nebraska's Coordinating Commission for Postsecondary Education, 2016

2016-01-01

The 2016 Nebraska Higher Education Progress Report is the 12th annual progress report designed to provide the Nebraska Legislature with comparative statistics to monitor and evaluate progress toward achieving three key priorities for Nebraska's postsecondary education system. These priorities were developed by the 2003 LR 174 Higher Education Task…

What Is Scientifically-Based Research on Progress Monitoring?

ERIC Educational Resources Information Center

Fuchs, Lynn S.; Fuchs, Douglas

2001-01-01

When teachers use systematic progress monitoring to track their students progress in reading, mathematics, or spelling, they are better able to identify students in need of additional or different forms of instruction, they design stronger instructional programs, and their students achieve better. This document first describes progress monitoring…

24 CFR 598.430 - Revocation of designation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... approval from HUD; (2) Has failed to make progress in implementing the strategic plan; or (3) Has not complied substantially with the strategic plan. (b) Letter of warning. Before revoking the designation of... complying substantially with, or has failed to make progress in implementing the strategic plan; and (2...

24 CFR 598.430 - Revocation of designation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... approval from HUD; (2) Has failed to make progress in implementing the strategic plan; or (3) Has not complied substantially with the strategic plan. (b) Letter of warning. Before revoking the designation of... complying substantially with, or has failed to make progress in implementing the strategic plan; and (2...

Progress on the Design of the Storage Ring Vacuum System for the Advanced Photon Source Upgrade Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stillwell, B.; Billett, B.; Brajuskovic, B.

2017-06-20

Recent work on the design of the storage ring vacuum system for the Advanced Photon Source Upgrade project (APS-U) includes: revising the vacuum system design to accommodate a new lattice with reverse bend magnets, modifying the designs of vacuum chambers in the FODO sections for more intense incident synchrotron radiation power, modifying the design of rf-shielding bellows liners for better performance and reliability, modifying photon absorber designs to make better use of available space, and integrated planning of components needed in the injection, extraction and rf cavity straight sections. An overview of progress in these areas is presented.

Learning Progressions as Evolving Tools in Joint Enterprises for Educational Improvement

ERIC Educational Resources Information Center

Penuel, William R.

2015-01-01

In their article, "Using Learning Progressions to Design Vertical Scales that Support Coherent Inferences about Student Growth," Briggs and Peck (this issue) argue that an important goal of assessment should be "to support coherent and actionable inferences of growth." They suggest that current approaches to test design rely on…

Biomarkers Predicting Progression of Human Immunodeficiency Virus-Related Disease

PubMed Central

Kanekar, Amar

2010-01-01

Biomarkers in predicting the progression of HIV infected individuals to a state of HIV disease (AIDS) are studied over more than a decade. Use of surrogate markers in the past for tracking clinical progression of the disease was limited, as little knowledge existed about the disease. The aim of this review was to address various changes in biomarker related studies taking place over the last five years, especially the trend towards use of newer biomarkers and experimentation with novel molecules in a quest for halting HIV disease progression. An open search of PUBMED database was made with search 'key words' such as 'Biomarkers' and 'AIDS (Acquired Immunodeficiency Syndrome)'.The following were the inclusion criteria for articles: a) all articles published in English language, b) years of publication between 2002-2008 and c) articles limited to adult population. This yielded a total of 417 articles. The criteria used for further judging these studies considered a) type of research design, b) number of biomarkers studied, c) validity of the biomarkers, d) techniques to assess the biomarkers and the impact of the studies in furthering biomarker research, e) sample size for the studies and f) article title or abstracts having the following key words 'biomarker' or 'biomarkers' and 'predict progression to AIDS'. A total of 27 abstracts were reviewed and 12 studies met the above criteria. These 12 different studies consisted of three reviews, four cohort designs, three cross-sectional designs, one each of an observational, and an in-vitro design. The various biomarkers emerging as a results were primarily a mix of viral, neural, immunological, HLA (human leukocyte antigen) markers along with lymphocyte counts. Although there have been quite a few advancements in biomarker-related studies, majority of the novel biomarkers discovered need to be further evaluated and replicated in bigger, long-term efficacy trials. Efforts should also be made to discover newer genetic markers of disease progression. Biomarker feedback, a new concept, can be utilized in future studies addressing prevention of HIV infection or halting disease progression. Keywords Biomarkers; Progression; Designs; HIV; AIDS; Validity PMID:21811520

NASA Multidisciplinary Design and Analysis Fellowship Program

NASA Technical Reports Server (NTRS)

1995-01-01

This report is a Year 1 interim report of the progress on the NASA multidisciplinary Design and Analysis Fellowship Program covering the period, January 1, 1995 through September 30, 1995. It summarizes progress in establishing the MDA Fellowship Program at Georgia Tech during the initial year. Progress in the advertisement of the program, recruiting results for the 1995-96 academic year, placement of the Fellows in industry during Summer 1995, program development at the M.S. and Ph.D. levels, and collaboration and dissemination of results are summarized in this report. Further details of the first year's progress will be included in the report from the Year 1 Workshop to be held at NASA Langley on December 7-8, 1995.

Design for progressive fracture in composite shell structures

NASA Technical Reports Server (NTRS)

Minnetyan, Levon; Murthy, Pappu L. N.

1992-01-01

The load carrying capability and structural behavior of composite shell structures and stiffened curved panels are investigated to provide accurate early design loads. An integrated computer code is utilized for the computational simulation of composite structural degradation under practical loading for realistic design. Damage initiation, growth, accumulation, and propagation to structural fracture are included in the simulation. Progressive fracture investigations providing design insight for several classes of composite shells are presented. Results demonstrate the significance of local defects, interfacial regions, and stress concentrations on the structural durability of composite shells.

Applying Item Response Theory methods to design a learning progression-based science assessment

NASA Astrophysics Data System (ADS)

Chen, Jing

Learning progressions are used to describe how students' understanding of a topic progresses over time and to classify the progress of students into steps or levels. This study applies Item Response Theory (IRT) based methods to investigate how to design learning progression-based science assessments. The research questions of this study are: (1) how to use items in different formats to classify students into levels on the learning progression, (2) how to design a test to give good information about students' progress through the learning progression of a particular construct and (3) what characteristics of test items support their use for assessing students' levels. Data used for this study were collected from 1500 elementary and secondary school students during 2009--2010. The written assessment was developed in several formats such as the Constructed Response (CR) items, Ordered Multiple Choice (OMC) and Multiple True or False (MTF) items. The followings are the main findings from this study. The OMC, MTF and CR items might measure different components of the construct. A single construct explained most of the variance in students' performances. However, additional dimensions in terms of item format can explain certain amount of the variance in student performance. So additional dimensions need to be considered when we want to capture the differences in students' performances on different types of items targeting the understanding of the same underlying progression. Items in each item format need to be improved in certain ways to classify students more accurately into the learning progression levels. This study establishes some general steps that can be followed to design other learning progression-based tests as well. For example, first, the boundaries between levels on the IRT scale can be defined by using the means of the item thresholds across a set of good items. Second, items in multiple formats can be selected to achieve the information criterion at all the defined boundaries. This ensures the accuracy of the classification. Third, when item threshold parameters vary a bit, the scoring rubrics and the items need to be reviewed to make the threshold parameters similar across items. This is because one important design criterion of the learning progression-based items is that ideally, a student should be at the same level across items, which means that the item threshold parameters (d1, d 2 and d3) should be similar across items. To design a learning progression-based science assessment, we need to understand whether the assessment measures a single construct or several constructs and how items are associated with the constructs being measured. Results from dimension analyses indicate that items of different carbon transforming processes measure different aspects of the carbon cycle construct. However, items of different practices assess the same construct. In general, there are high correlations among different processes or practices. It is not clear whether the strong correlations are due to the inherent links among these process/practice dimensions or due to the fact that the student sample does not show much variation in these process/practice dimensions. Future data are needed to examine the dimensionalities in terms of process/practice in detail. Finally, based on item characteristics analysis, recommendations are made to write more discriminative CR items and better OMC, MTF options. Item writers can follow these recommendations to write better learning progression-based items.

Advanced Telemetry System Development.

DTIC Science & Technology

Progress in advanced telemetry system development is described. Discussions are included of studies leading to the specification for design...characteristics of adaptive and analytical telemetry systems in which the information efficiently utilizes the data channel capacity. Also discussed are...Progress indicates that further sophistication of existing designs in telemetry will be less advantageous than the development of new systems of

SPIRIT: A seamless phase I/II randomized design for immunotherapy trials.

PubMed

Guo, Beibei; Li, Daniel; Yuan, Ying

2018-06-07

Immunotherapy-treatments that enlist the immune system to battle tumors-has received widespread attention in cancer research. Due to its unique features and mechanisms for treating cancer, immunotherapy requires novel clinical trial designs. We propose a Bayesian seamless phase I/II randomized design for immunotherapy trials (SPIRIT) to find the optimal biological dose (OBD) defined in terms of the restricted mean survival time. We jointly model progression-free survival and the immune response. Progression-free survival is used as the primary endpoint to determine the OBD, and the immune response is used as an ancillary endpoint to quickly screen out futile doses. Toxicity is monitored throughout the trial. The design consists of two seamlessly connected stages. The first stage identifies a set of safe doses. The second stage adaptively randomizes patients to the safe doses identified and uses their progression-free survival and immune response to find the OBD. The simulation study shows that the SPIRIT has desirable operating characteristics and outperforms the conventional design. Copyright © 2018 John Wiley & Sons, Ltd.

Lightning Simulation and Design Program (LSDP)

NASA Astrophysics Data System (ADS)

Smith, D. A.

This computer program simulates a user-defined lighting configuration. It has been developed as a tool to aid in the design of exterior lighting systems. Although this program is used primarily for perimeter security lighting design, it has potential use for any application where the light can be approximated by a point source. A data base of luminaire photometric information is maintained for use with this program. The user defines the surface area to be illuminated with a rectangular grid and specifies luminaire positions. Illumination values are calculated for regularly spaced points in that area and isolux contour plots are generated. The numerical and graphical output for a particular site mode are then available for analysis. The amount of time spent on point-to-point illumination computation with this progress is much less than that required for tedious hand calculations. The ease with which various parameters can be interactively modified with the progress also reduces the time and labor expended. Consequently, the feasibility of design ideas can be examined, modified, and retested more thoroughly, and overall design costs can be substantially lessened by using this progress as an adjunct to the design process.

Recent progresses in outcome-dependent sampling with failure time data.

PubMed

Ding, Jieli; Lu, Tsui-Shan; Cai, Jianwen; Zhou, Haibo

2017-01-01

An outcome-dependent sampling (ODS) design is a retrospective sampling scheme where one observes the primary exposure variables with a probability that depends on the observed value of the outcome variable. When the outcome of interest is failure time, the observed data are often censored. By allowing the selection of the supplemental samples depends on whether the event of interest happens or not and oversampling subjects from the most informative regions, ODS design for the time-to-event data can reduce the cost of the study and improve the efficiency. We review recent progresses and advances in research on ODS designs with failure time data. This includes researches on ODS related designs like case-cohort design, generalized case-cohort design, stratified case-cohort design, general failure-time ODS design, length-biased sampling design and interval sampling design.

Recent progresses in outcome-dependent sampling with failure time data

PubMed Central

Ding, Jieli; Lu, Tsui-Shan; Cai, Jianwen; Zhou, Haibo

2016-01-01

An outcome-dependent sampling (ODS) design is a retrospective sampling scheme where one observes the primary exposure variables with a probability that depends on the observed value of the outcome variable. When the outcome of interest is failure time, the observed data are often censored. By allowing the selection of the supplemental samples depends on whether the event of interest happens or not and oversampling subjects from the most informative regions, ODS design for the time-to-event data can reduce the cost of the study and improve the efficiency. We review recent progresses and advances in research on ODS designs with failure time data. This includes researches on ODS related designs like case–cohort design, generalized case–cohort design, stratified case–cohort design, general failure-time ODS design, length-biased sampling design and interval sampling design. PMID:26759313

Ultra-dense magnetoresistive mass memory

NASA Technical Reports Server (NTRS)

Daughton, J. M.; Sinclair, R.; Dupuis, T.; Brown, J.

1992-01-01

This report details the progress and accomplishments of Nonvolatile Electronics (NVE), Inc., on the design of the wafer scale MRAM mass memory system during the fifth quarter of the project. NVE has made significant progress this quarter on the one megabit design in several different areas. A test chip, which will verify a working GMR bit with the dimensions required by the 1 Meg chip, has been designed, laid out, and is currently being processed in the NVE labs. This test chip will allow electrical specifications, tolerances, and processing issues to be finalized before construction of the actual chip, thus providing a greater assurance of success of the final 1 Meg design. A model has been developed to accurately simulate the parasitic effects of unselected sense lines. This model gives NVE the ability to perform accurate simulations of the array electronic and test different design concepts. Much of the circuit design for the 1 Meg chip has been completed and simulated and these designs are included. Progress has been made in the wafer scale design area to verify the reliable operation of the 16 K macrocell. This is currently being accomplished with the design and construction of two stand alone test systems which will perform life tests and gather data on reliabiliy and wearout mechanisms for analysis.

Ares V: Current Status and Future Capabilities

NASA Technical Reports Server (NTRS)

Sumrall, Phil

2009-01-01

This slide presentation reviews the progress made in the design and development of the Ares V launch vehicle. Included in the presentation are views of the elements of the Ares V, the commonality of the Ares I and V, a chart that shows the progress made in the design of the launcher, description of the current activities around the design and preparation for the Ares V, and a slide describing the prospect of large payload volume and the flexibility that this gives to new space sciences.

Quantitative Reasoning in Environmental Science: A Learning Progression

ERIC Educational Resources Information Center

Mayes, Robert Lee; Forrester, Jennifer Harris; Christus, Jennifer Schuttlefield; Peterson, Franziska Isabel; Bonilla, Rachel; Yestness, Nissa

2014-01-01

The ability of middle and high school students to reason quantitatively within the context of environmental science was investigated. A quantitative reasoning (QR) learning progression was created with three progress variables: quantification act, quantitative interpretation, and quantitative modeling. An iterative research design was used as it…

The research progress on Hodograph Method of aerodynamic design at Tsinghua University

NASA Technical Reports Server (NTRS)

Chen, Zuoyi; Guo, Jingrong

1991-01-01

Progress in the use of the Hodograph method of aerodynamic design is discussed. It was found that there are some restricted conditions in the application of Hodograph design to transonic turbine and compressor cascades. The Hodograph method is suitable not only to the transonic turbine cascade but also to the transonic compressor cascade. The three dimensional Hodograph method will be developed after obtaining the basic equation for the three dimensional Hodograph method. As an example of the Hodograph method, the use of the method to design a transonic turbine and compressor cascade is discussed.

Progress in multidisciplinary design optimization at NASA Langley

NASA Technical Reports Server (NTRS)

Padula, Sharon L.

1993-01-01

Multidisciplinary Design Optimization refers to some combination of disciplinary analyses, sensitivity analysis, and optimization techniques used to design complex engineering systems. The ultimate objective of this research at NASA Langley Research Center is to help the US industry reduce the costs associated with development, manufacturing, and maintenance of aerospace vehicles while improving system performance. This report reviews progress towards this objective and highlights topics for future research. Aerospace design problems selected from the author's research illustrate strengths and weaknesses in existing multidisciplinary optimization techniques. The techniques discussed include multiobjective optimization, global sensitivity equations and sequential linear programming.

Exploring Alignment among Learning Progressions, Teacher-Designed Formative Assessment Tasks, and Student Growth: Results of a Four-Year Study

ERIC Educational Resources Information Center

Furtak, Erin Marie; Circi, Ruhan; Heredia, Sara C.

2018-01-01

This article describes a 4-year study of experienced high school biology teachers' participation in a five-step professional development experience in which they iteratively studied student ideas with the support of a set of learning progressions, designed formative assessment activities, practiced using those activities with their students,…

Advances on the constitutive characterization of composites via multiaxial robotic testing and design optimization

Treesearch

John G. Michopoulos; John Hermanson; Athanasios Iliopoulos

2014-01-01

The research areas of mutiaxial robotic testing and design optimization have been recently utilized for the purpose of data-driven constitutive characterization of anisotropic material systems. This effort has been enabled by both the progress in the areas of computers and information in engineering as well as the progress in computational automation. Although our...

Progress on SOFIA primary mirror

NASA Astrophysics Data System (ADS)

Geyl, Roland; Tarreau, Michel

2000-06-01

REOSC, SAGEM Group, has a significant contribution to the SOFIA project with the design and fabrication of the 2.7-m primary mirror and its fixtures as well as the M3 mirror tower assembly. This paper will primarily report the progress made on the primary mirror design and the first important manufacturing step: its lightweighting by machining pockets from the rear side of the blank.

NAEP Reconfigured: An Integrated Redesign of the National Assessment of Educational Progress. Working Paper Series.

ERIC Educational Resources Information Center

Johnson, Eugene G.; Lazer, Stephen; O'Sullivan, Christine Y.

Chapters in this report outline the potential plans for the redesign of the National Assessment of Educational Progress (NAEP). It is argued that any successful redesign must consider the NAEP as a whole. This report reviews overall NAEP designs and discusses the implications that each of the designs has for various functional areas. The following…

Learning Progressions and Teaching Sequences: A Review and Analysis

ERIC Educational Resources Information Center

Duschl, Richard; Maeng, Seungho; Sezen, Asli

2011-01-01

Our paper is an analytical review of the design, development and reporting of learning progressions and teaching sequences. Research questions are: (1) what criteria are being used to propose a "hypothetical learning progression/trajectory" and (2) what measurements/evidence are being used to empirically define and refine a "hypothetical learning…

24 CFR 598.420 - Periodic progress determinations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF... evaluate the progress of implementation of the strategic plan in each designated Empowerment Zone on the...

Recent Sikorsky R and D progress

NASA Technical Reports Server (NTRS)

1988-01-01

The recent activities and progress in four specific areas of Sikorsky's research and development program are summarized. Since the beginning of the S-76 design in 1974, Sikorsky has been aggressively developing the technology for using composite materials in helicopter design. Four specific topics are covered: advanced cockpit/controller efforts, fly-by-wire controls on RSRA/X-Wing, vibration control via higher harmonic control, and main rotor aerodynamic improvements.

Learning Progressions, Vertical Scales, and Testable Hypotheses: Promising Intuitions and Points for Clarification

ERIC Educational Resources Information Center

Maul, Andrew

2015-01-01

Briggs and Peck [in "Using Learning Progressions to Design Vertical Scales That Support Coherent Inferences about Student Growth"] call for greater care in the conceptualization of the target attributes of students, or "what it is that is growing from grade to grade." In particular, they argue that learning progressions can…

Progress Check Module; Basic Electricity and Electronics Individualized Learning System. Progress Check Booklet.

ERIC Educational Resources Information Center

Bureau of Naval Personnel, Washington, DC.

The Progress Check Booklet is designed to be used by the student working in the programed course to determine if he has mastered the concepts in the course booklets on: electrical current; voltage; resistance; measuring current and voltage in series circuits; relationships of current, voltage, and resistance; parellel circuits; combination…

HKHC Community Dashboard: design, development, and function of a Web-based performance monitoring system.

PubMed

Bors, Philip A; Kemner, Allison; Fulton, John; Stachecki, Jessica; Brennan, Laura K

2015-01-01

As part of Robert Wood Johnson Foundation's Healthy Kids, Healthy Communities (HKHC) national grant program, a technical assistance team designed the HKHC Community Dashboard, an online progress documentation and networking system. The Dashboard was central to HKHC's multimethod program evaluation and became a communication interface for grantees and technical assistance providers. The Dashboard was designed through an iterative process of identifying needs and priorities; designing the user experience, technical development, and usability testing; and applying visual design. The system was created with an open-source content management system and support for building an online community of users. The site developer trained technical assistance providers at the national program office and evaluators, who subsequently trained all 49 grantees. Evaluators provided support for Dashboard users and populated the site with the bulk of its uploaded tools and resource documents. The system tracked progress through an interactive work plan template, regular documentation by local staff and partners, and data coding and analysis by the evaluation team. Other features included the ability to broadcast information to Dashboard users via e-mail, event calendars, discussion forums, private messaging, a resource clearinghouse, a technical assistance diary, and real-time progress reports. The average number of Dashboard posts was 694 per grantee during the grant period. Technical assistance providers and grantees uploaded a total of 1304 resource documents. The Dashboard functions with the highest grantee satisfaction were its interfaces for sharing and progress documentation. A majority of Dashboard users (69%) indicated a preference for continued access to the Dashboard's uploaded resource documents. The Dashboard was a useful and innovative tool for participatory evaluation of a large national grant program. While progress documentation added some burden to local project staff, the system proved to be a useful resource-sharing technology.

Modeling Tumor Clonal Evolution for Drug Combinations Design.

PubMed

Zhao, Boyang; Hemann, Michael T; Lauffenburger, Douglas A

2016-03-01

Cancer is a clonal evolutionary process. This presents challenges for effective therapeutic intervention, given the constant selective pressure towards drug resistance. Mathematical modeling from population genetics, evolutionary dynamics, and engineering perspectives are being increasingly employed to study tumor progression, intratumoral heterogeneity, drug resistance, and rational drug scheduling and combinations design. In this review, we discuss promising opportunities these inter-disciplinary approaches hold for advances in cancer biology and treatment. We propose that quantitative modeling perspectives can complement emerging experimental technologies to facilitate enhanced understanding of disease progression and improved capabilities for therapeutic drug regimen designs.

Antigenicity and Immunogenicity in HIV-1 Antibody-Based Vaccine Design

PubMed Central

Kong, Leopold; Sattentau, Quentin J

2012-01-01

Neutralizing antibodies can protect from infection by immunodeficiency viruses. However, the induction by active vaccination of antibodies that can potently neutralize a broad range of circulating virus strains is a goal not yet achieved, despite more than 2 decades of research. Here we review progress made in the field, from early empirical studies to today’s rational structure-based vaccine antigen design. We discuss the existence of broadly neutralizing antibodies, their implications for epitope discovery and recent progress made in antigen design. Finally, we consider the relationship between antigenicity and immunogenicity for B cell recognition and antibody production, a major hurdle for rational vaccine design to overcome. PMID:23227445

Solar hot water space heating system. Technical progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Dam, T

1979-08-13

A retrofit solar heating system was installed on Madison Hall at Jordan College, Cedar Springs, Michigan. The system provides heating and domestic water preheating for a campus dormitory. Freeze protection is provided by a draindown system. The building and solar system, construction progress, and design changes are described. Included in appendices are: condensate trap design, structural analysis, pictures of installation, operating instructions, maintenance instructions, and as-built drawings. (MHR)

Thermal structures: Four decades of progress

NASA Technical Reports Server (NTRS)

Thornton, Earl A.

1990-01-01

Since the first supersonic flight in October 1947, the United States has designed, developed and flown flight vehicles within increasingly severe aerothermal environments. Over this period, major advances in engineering capabilities have occurred that will enable the design of thermal structures for high speed flight vehicles in the twenty-first century. Progress in thermal-structures is surveyed for the last four decades to provide a historical perspective for future efforts.

Final Technical Progress Report: Development of Low-Cost Suspension Heliostat; December 7, 2011 - December 6, 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bender, W.

2013-01-01

Final technical progress report of SunShot Incubator Solaflect Energy. The project succeeded in demonstrating that the Solaflect Suspension Heliostat design is viable for large-scale CSP installations. Canting accuracy is acceptable and is continually improving as Solaflect improves its understanding of this design. Cost reduction initiatives were successful, and there are still many opportunities for further development and further cost reduction.

An Analysis of Stative Verbs Used with the Progressive Aspect in Corpus-Informed Textbooks

ERIC Educational Resources Information Center

Belli, Serap Atasever

2018-01-01

This study was designed to investigate whether contemporary corpus-informed grammar textbooks written for English language learners and teachers presented the progressive use of stative verbs and if yes, which stative verbs were presented to occur with the progressive aspect and for which functions they took this aspect. A corpus of six electronic…

Status of States' Progress in Implementing Part H of IDEA: Report #3.

ERIC Educational Resources Information Center

Harbin, Gloria L.; And Others

This report focuses on progress in the implementation of Part H of the Individuals with Disabilities Education Act (IDEA) through a comparison of states' status on three yearly administrations of the State Progress Scale. The scale was designed to monitor implementation of the required 14 components in the stages of policy development, policy…

[Individual Progress Program for the Extremely Gifted Student in the Greater Seattle Area.

ERIC Educational Resources Information Center

Norsen, Barbara G.; Wick, Christine

The Individual Progress Program (IPP) is an approach designed to serve extremely advanced gifted students (grades 1 through 9) in the Seattle area. IPP is intended to meet students' unmet educational needs by allowing them to progress at their own accelerated pace through a broadly based curriculum while also pursuing interest areas. The program…

Creating Coherent Incidental Learning Journeys on Smartphones Using Feedback and Progress Indicators: The SCAMP Framework

ERIC Educational Resources Information Center

Jones, Ann; Gaved, Mark; Kukulska-Hulme, Agnes; Scanlon, Eileen; Pearson, Charlie; Lameras, Petros; Dunwell, Ian; Jones, Jan

2014-01-01

Although the motivating role of feedback and progress indicators is understood in formal learning, their role in supporting incidental mobile learning is less well understood. In this paper we argue that well-designed feedback and progress indicators (FPIs) offer guidance and structure that may encourage mobile app users to move from fragmented…

A Method to Reveal Fine-Grained and Diverse Conceptual Progressions during Learning

ERIC Educational Resources Information Center

Lombard, François; Merminod, Marie; Widmer, Vincent; Schneider, Daniel K.

2018-01-01

Empirical data on learners' conceptual progression is required to design curricula and guide students. In this paper, we present the Reference Map Change Coding (RMCC) method for revealing students' progression at a fine-grained level. The method has been developed and tested through the analysis of successive versions of the productions of eight…

Students, Teachers, and Schools as Sources of Variability, Integrity, and Sustainability in Implementing Progress Monitoring

ERIC Educational Resources Information Center

Bolt, Daniel M.; Ysseldyke, Jim; Patterson, Michael J.

2010-01-01

A three-level variance decomposition analysis was used to examine the sources of variability in implementation of a technology-enhanced progress monitoring system within each year of a 2-year study using a randomized-controlled design. We show that results of technology-enhanced progress monitoring are not necessarily a measure of student…

Veterans’ Health Care: Limited Progress Made to Address Concerns That Led to High Risk Designation

DTIC Science & Technology

2017-03-15

partially meet two of the five criteria GAO uses to assess removal from the High-Risk List ( leadership commitment and an action plan), but it has not met...the other three (agency capacity, monitoring efforts, and demonstrated progress). Specifically, VA officials have taken leadership actions such as...high-risk designation, additional actions are required of VA, including: (1) demonstrating stronger leadership support as it continues its

Nuclear Power Plant Mechanical Component Flooding Fragility Experiments Status

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pope, C. L.; Savage, B.; Johnson, B.

This report describes progress on Nuclear Power Plant mechanical component flooding fragility experiments and supporting research. The progress includes execution of full scale fragility experiments using hollow-core doors, design of improvements to the Portal Evaluation Tank, equipment procurement and initial installation of PET improvements, designation of experiments exploiting the improved PET capabilities, fragility mathematical model development, Smoothed Particle Hydrodynamic simulations, wave impact simulation device research, and pipe rupture mechanics research.

Terrestrial Planet Finder Interferometer: 2007-2008 Progress and Plans

NASA Technical Reports Server (NTRS)

Lawson, P. R.; Lay, O. P.; Martin, S. R.; Peters, R. D.; Gappinger, R. O.; Ksendzov, A.; Scharf, D. P.; Booth, A. J.; Beichman, C. A.; Serabyn, E.;

Modeling Tumor Clonal Evolution for Drug Combinations Design

PubMed Central

Zhao, Boyang; Hemann, Michael T.; Lauffenburger, Douglas A.

2016-01-01

Cancer is a clonal evolutionary process. This presents challenges for effective therapeutic intervention, given the constant selective pressure towards drug resistance. Mathematical modeling from population genetics, evolutionary dynamics, and engineering perspectives are being increasingly employed to study tumor progression, intratumoral heterogeneity, drug resistance, and rational drug scheduling and combinations design. In this review, we discuss promising opportunities these inter-disciplinary approaches hold for advances in cancer biology and treatment. We propose that quantitative modeling perspectives can complement emerging experimental technologies to facilitate enhanced understanding of disease progression and improved capabilities for therapeutic drug regimen designs. PMID:28435907

Progress on the Design of a Perpendicularly Biased 2nd Harmonic Cavity for the Fermilab Booster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Madrak, R. L.; Dey, J. E.; Duel, K. L.

2016-10-01

perpendicularly biased 2nd harmonic cavity is being designed and built for the Fermilab Booster. Its purpose is to flatten the bucket at injection and thus change the longitudinal beam distribution to decrease space charge effects. It can also help at extraction. The cavity frequency range is 76 – 106 MHz. The power amplifier will be built using the Y567B tetrode, which is also used for the fundamental mode cavities in the Fermilab Booster. We discuss recent progress on the cavity, the biasing solenoid design and plans for testing the tuner's garnet material

Progress on the European Extremely Large Telescope

NASA Astrophysics Data System (ADS)

Spyromilio, Jason; Comerón, Fernando; D'Odorico, Sandro; Kissler-Patig, Markus; Gilmozzi, Roberto

2008-09-01

In December 2006 the ESO Council gave the go-ahead for the European Extremely Large Telescope (E-ELT) three-year Phase B study. The Baseline Reference Design (BRD) was presented to the ESO committees in 2006 and to the community at the Marseille meeting in December 2006. Phase B has been running for one and a half years and a progress report is presented covering science activities, telescope design, instrumentation, site selection and operations. The designs are maturing, in close synergy with industrial contracts, and the proposal for E-ELT construction is expected to be presented to the ESO Council in June 2010.

Senior Design in Agricultural Engineering--Progress and Pitfalls.

ERIC Educational Resources Information Center

Holmes, R. G.; Rohrbach, R. P.

1979-01-01

Describes a specific senior design course and its objectives. Explains the basic deficiencies and problems for design education in agricultural engineering. Also stresses the effect the project advisor has on students' attitudes toward design and the applications of the course. (SMB)

Development of local calibration factors and design criteria values for mechanistic-empirical pavement design.

DOT National Transportation Integrated Search

2015-08-01

A mechanistic-empirical (ME) pavement design procedure allows for analyzing and selecting pavement structures based : on predicted distress progression resulting from stresses and strains within the pavement over its design life. The Virginia : Depar...

Building Capacity in Understanding Foundational Biology Concepts: A K-12 Learning Progression in Genetics Informed by Research on Children's Thinking and Learning

ERIC Educational Resources Information Center

Elmesky, Rowhea

2013-01-01

This article describes the substance, structure, and rationale of a learning progression in genetics spanning kindergarten through twelfth grade (K-12). The learning progression is designed to build a foundation towards understanding protein structure and activity and should be viewed as one possible pathway to understanding concepts of genetics…

SYSTEM DESIGN FOR A CONTINUOUS PROGRESS SCHOOL--PART III, THE INSTRUCTIONAL MATERIALS CENTER.

ERIC Educational Resources Information Center

COGSWELL, JOHN F.; EGBERT, ROBERT L.

THE INSTRUCTIONAL MATERIALS CENTER (IMC) OF THE CONTINUOUS PROGRESS SCHOOL WAS DESCRIBED. THE CONTINUOUS PROGRESS SCHOOL PLAN WAS DEVISED BY DR. EDWIN READ AND WAS BEING DEVELOPED AT THE LABORATORY SCHOOL OF BRIGHAM YOUNG UNIVERSITY. THIS REPORT DESCRIBED HOW AN IMC MIGHT OPERATE RATHER THAN HOW ONE IS OPERATING OR IS PLANNED TO OPERATE. AS…

Therapist and Patient Perceptions of Alliance and Progress in Psychological Therapy for Women Diagnosed with Gynecological Cancers

ERIC Educational Resources Information Center

Manne, Sharon L.; Kashy, Deborah A.; Rubin, Stephen; Hernandez, Enrique; Bergman, Cynthia

2012-01-01

Objective: The goal was to understand both therapist and patient perspectives on alliance and session progress for women in treatment for gynecological cancer. We used a longitudinal version of the one-with-many design to partition variation in alliance and progress ratings into therapist, patient/dyad, and time-specific components. We also…

Theoretical and experimental investigation of design for multioptical-axis freeform progressive addition lenses

NASA Astrophysics Data System (ADS)

Xiang, HuaZhong; Chen, JiaBi; Zhu, TianFen; Wei, YeFei; Fu, DongXiang

2015-11-01

A freeform progressive addition lens (PAL) provides a good solution to correct presbyopia and prevent juvenile myopia by distributing pupils' optical powers of distance zone, near zone, and intermediate zone and is more widely adopted in the present optometric study. However, there is still a lack of a single-optical-axis system for the design of a PAL. This paper focuses on the research for an approach for designing a freeform PAL. A multioptical-axis system based on real viewing conditions using the eyes is employed for the representation of the freeform surface. We filled small pupils in the intermediate zone as a progressive corridor and the distance- and near-vision portions were defined as the standard spherical surfaces delimited by quadratic curves. Three freeform PALs with a spherical surface as the front side and a freeform surface as the backside were designed. We demonstrate the fabrication and measurement technologies for the PAL surface using computer numerical control machine tools from Schneider Smart and a Visionix VM-2000 Lens Power Mapper. Surface power and astigmatic values were obtained. Preliminary results showed that the approach for the design and fabrication is helpful to advance the design procedure optimization and mass production of PALs in optometry.

Designing a Better Navy Aviation Retention Bonus

DTIC Science & Technology

2017-03-01

5 A. AVIATOR CAREER PROGRESSION ...................................................5 1. Flight...7  Figure 3.  Aviation Officer Career Progression...ABBREVIATIONS ACCP Aviation Career Continuation Pay ACIP Aviation Career Incentive Pay ACP Aviation Continuation Pay ACRB Aviation Command Retention Bonus

Systems integration of marketable subsystems: A collection of progress reports

NASA Technical Reports Server (NTRS)

1978-01-01

Monthly progress reports are given in the areas of marketable subsystems integration; development, design, and building of site data acquisition subsystems and data processing systems; operation of the solar test facility and a systems analysis.

Design of An 18 MW Beam Dump for 500 GeV Electron/Positron Beams at An ILC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amann, John; /SLAC; Arnold, Ray

This article presents a report on the progress made in designing 18 MW water based Beam Dumps for electrons or positrons for an International Linear Collider (ILC). Multi-dimensional technology issues have to be addressed for the successful design of the Beam Dump. They include calculations of power deposition by the high energy electron/positron beam bunch trains, computational fluid dynamic analysis of turbulent water flow, mechanical design, process flow analysis, hydrogen/oxygen recombiners, handling of radioactive 7Be and 3H, design of auxiliary equipment, provisions for accident scenarios, remote window exchanger, radiation shielding, etc. The progress made to date is summarized, the currentmore » status, and also the issues still to be addressed.« less

NGST Yardstick Integrated Science Instrument Module (ISIM) Feasibility Study

NASA Astrophysics Data System (ADS)

Greenhouse, M. A.; Dipirro, M.; Federline, B.; Gardner, Jonathan P.; Guy, P.; Hagopian, J.; Hein, J.; Jurotich, M.; Lawrence, J.; Martineau, B.; Mather, J. C.; Mentzell, E.; Satyapal, S.; Stanley, D.; Teplitz, H. I.; Travis, J.; Bely, P.; Petro, L. D.; Stockman, P.; Burg, R.; Bitzel, R.

1998-12-01

We display portions of the baseline design concept for the NGST Integrated Science Instrument Module (ISIM). This ISIM design is under ongoing development for integration with the "Yardstick" and other NGST 8 m architectures that are intended for packaging in an EELV or Ariane 5 meter class fairing. The goals of this activity are to: [1] demonstrate mission science feasibility, [2] identify ISIM technology challenge areas, [3] assess ISIM engineering and cost feasibility, [5] identify ISIM/NGST interface constraints, and [6] enable smart customer procurement of the ISIM. In this poster, we display a snap shot of work in progress including: optical design, opto-mechanical layout, thermal modeling, focal plane array design, and electronics design. Ongoing progress can be monitored via ISIM team web site: http://ngst.gsfc.nasa.gov/

Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives

PubMed Central

Ontaneda, Daniel; Fox, Robert J.; Chataway, Jeremy

2015-01-01

Progressive multiple sclerosis is characterized by the gradual accrual of disability independent of relapses and can occur with disease onset (primary progressive) or preceded by a relapsing disease course (secondary progressive). An effective disease modifying treatment for progressive multiple sclerosis has not been identified, and the results of clinical trials to date have been generally disappointing. Ongoing advances in our understanding of pathogenesis, identification of novel targets for neuro-protection, and improved outcome measures have the potential to lead to effective treatments for progressive multiple sclerosis. In this review lessons learned from previous clinical trials and perspectives from current trials in progressive multiple sclerosis are summarized. Promising clinical, imaging, and biological markers will also be reviewed, along with novel clinical trial designs. PMID:25772899

Interactive Environment Design in Smart City

NASA Astrophysics Data System (ADS)

Deng, DeXiang; Chen, LanSha; Zhou, Xi

2017-08-01

The interactive environment design of smart city is not just an interactive progress or interactive mode design, rather than generate an environment such as the “organic” life entity as human beings through interactive design, forming a smart environment with perception, memory, thinking, and reaction.

An Integrated Assessment of Progress in Robotic Perception and Semantic Navigation

DTIC Science & Technology

2015-09-01

3 Each pixel within the 2-dimensional (2-D) image is labeled as being one of several types: building, grass, tree, sky, concrete , asphalt , gravel...The findings in this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents...October 2014, the RCTA assessed progress toward integrating this research. This assessment was designed to evaluate the robot’s performance when it

Terrestrial Planet Finder Interferometer: Architecture, Mission Design, and Technology Development

NASA Technical Reports Server (NTRS)

Henry, Curt

2004-01-01

This slide presentation represents an overview progress report about the system design and technology development of two interferometer concepts studied for the Terrestrial Planet Finder (TPF) project. The two concepts are a structurally-connected interferometer (SCI) intended to fulfill minimum TPF science goals and a formation-flying interferometer (FFI) intended to fulfill full science goals. Described are major trades, analyses, and technology experiments completed. Near term plans are also described. This paper covers progress since August 2003

Use of music during physical therapy intervention for an infant with Erb's palsy: a single-subject design.

PubMed

Rahlin, Mary; Cech, Donna; Rheault, Wendy; Stoecker, Judith

2007-01-01

Evidence supporting the use of music during pediatric physical therapy intervention is limited. The purpose of this single-subject design was to evaluate the effects of music on patient progress, the amount of crying during therapy, and parent satisfaction with physical therapy services. The subject was an infant girl with Erb's palsy who participated in this study from age 8 months to age 20 months. An A-B-A withdrawal single-subject design was used. The patient's progress was assessed by using the T.I.M.E. The amount of crying was documented in the Crying Log. A parent satisfaction questionnaire was administered three times over the course of the study. The subject's progress in the music intervention period increased on three of five primary subtests of the T.I.M.E. The amount of crying decreased and parent satisfaction increased when music was played during therapy. Music may be used by pediatric physical therapists to decrease the patient's crying, increase parent satisfaction, and possibly to increase the child's rate of progress. Further research conducted with a group of infants and toddlers may help generalize these findings to a wider patient population.

Accelerated Progress Through Self-Determination. Second Annual Report of the Choctaw Self-Determination Project, July 1, 1972 - October 31, 1973.

ERIC Educational Resources Information Center

Mississippi Band of Choctaw Indians, Philadelphia.

Self-determination for the Choctaw tribal government and its people was reflected in the progress made in program development. Programs in effect during fiscal year (FY) 1973 covered the full range of economic and social needs of the Choctaw people. Designed to complement the progress achieved during FY 1972, the following four developmental…

Design for inadvertent damage in composite laminates

NASA Technical Reports Server (NTRS)

Singhal, Surendra N.; Chamis, Christos C.

1992-01-01

Simplified predictive methods and models to computationally simulate durability and damage in polymer matrix composite materials/structures are described. The models include (1) progressive fracture, (2) progressively damaged structural behavior, (3) progressive fracture in aggressive environments, (4) stress concentrations, and (5) impact resistance. Several examples are included to illustrate applications of the models and to identify significant parameters and sensitivities. Comparisons with limited experimental data are made.

Learning Objects: A User-Centered Design Process

ERIC Educational Resources Information Center

Branon, Rovy F., III

2011-01-01

Design research systematically creates or improves processes, products, and programs through an iterative progression connecting practice and theory (Reinking, 2008; van den Akker, 2006). Developing a new instructional systems design (ISD) processes through design research is necessary when new technologies emerge that challenge existing practices…

Designing and measuring the progress and impact of health research capacity strengthening initiatives

PubMed Central

2015-01-01

Strengthening capacity in poorer countries to generate multi-disciplinary health research and to utilise research findings, is one of the most effective ways of advancing the countries' health and development. This paper explores current knowledge about how to design health research capacity strengthening (RCS) programmes and how to measure their progress and impact. It describes a systematic, evidence-based approach for designing such programmes and highlights some of the key challenges that will be faced in the next 10 years. These include designing and implementing common frameworks to facilitate comparisons among capacity strengthening projects, and developing monitoring indicators that can capture their interactions with knowledge users and their impact on changes in health systems. PMID:28281707

Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies

PubMed Central

Williamson, Paula R; Gamble, Carrol; O'Connell Francischetto, Elaine; Metcalfe, Chris; Davidson, Peter; Williams, Hywel; Blazeby, Jane M

2017-01-01

Objectives Designing studies with an internal pilot phase may optimise the use of pilot work to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed decision or ‘progression’ criteria at the juncture between the internal pilot and main trial phases provides a valuable opportunity to evaluate the likely success of the main trial and optimise its design or, if necessary, to make the decision not to proceed with the main trial. Guidance on the appropriate selection and application of progression criteria is, however, lacking. This paper outlines the key issues to consider in the optimal development and review of operational progression criteria for RCTs with an internal pilot phase. Design A structured literature review and exploration of stakeholders' opinions at a Medical Research Council (MRC) Hubs for Trials Methodology Research workshop. Key stakeholders included triallists, methodologists, statisticians and funders. Results There is considerable variation in the use of progression criteria for RCTs with an internal pilot phase, although 3 common issues predominate: trial recruitment, protocol adherence and outcome data. Detailed and systematic reporting around the decision-making process for stopping, amending or proceeding to a main trial is uncommon, which may hamper understanding in the research community about the appropriate and optimal use of RCTs with an internal pilot phase. 10 top tips for the development, use and reporting of progression criteria for internal pilot studies are presented. Conclusions Systematic and transparent reporting of the design, results and evaluation of internal pilot trials in the literature should be encouraged in order to facilitate understanding in the research community and to inform future trials. PMID:28213598

Engineering and Physics Optimization of Breed and Burn Fast Reactor Systems; NUCLEAR ENERGY RESEARCH INITIATIVE (NERI) QUARTERLY PROGRESS REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pavel Hejzlar, Peter Yarsky, Mike Driscoll, Dan Wachs, Kevan Weaver, Ken Czerwinski, Mike Pope, James Parry, Theron D. Marshall, Cliff B. Davis, Dustin Crawford, Thomas Hartmann, Pradip Saha; Hejzlar, Pavel; Yarsky, Peter

2005-01-31

This project is organized under four major tasks (each of which has two or more subtasks) with contributions among the three collaborating organizations (MIT, INEEL and ANL-West): Task A: Core Physics and Fuel Cycle; Task B: Core Thermal Hydraulics; Task C: Plant Design; Task D: Fuel Design The lead PI, Michael J. Driscoll, has consolidated and summarized the technical progress submissions provided by the contributing investigators from all sites, under the above principal task headings.

Trial design innovations: Clinical trials for treatment of neuropsychiatric symptoms in Alzheimer's Disease

PubMed Central

Zhong, K

2015-01-01

Neuropsychiatric symptoms are common in Alzheimer's disease (AD) and other neurodegenerative disorders. Recent progress has been made with clinical trials, advancing new therapies for psychosis in Parkinson's disease (PD), agitation in AD, and apathy in AD. Definitions have emerged for agitation and apathy in patients with cognitive impairment, facilitating recruitment of clinical trial populations. Progress in clinical trial design and the agents being assessed promise to advance therapies for disabling symptoms and improve quality of life for patients and caregivers. PMID:26206713

24 CFR 598.425 - Validation of designation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Validation of designation. 598.425 Section 598.425 Housing and Urban Development Regulations Relating to Housing and Urban Development...-Designation Requirements § 598.425 Validation of designation. (a) On the basis of the periodic progress...

24 CFR 598.425 - Validation of designation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Validation of designation. 598.425 Section 598.425 Housing and Urban Development Regulations Relating to Housing and Urban Development...-Designation Requirements § 598.425 Validation of designation. (a) On the basis of the periodic progress...

24 CFR 598.425 - Validation of designation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Validation of designation. 598.425 Section 598.425 Housing and Urban Development Regulations Relating to Housing and Urban Development...-Designation Requirements § 598.425 Validation of designation. (a) On the basis of the periodic progress...

24 CFR 598.425 - Validation of designation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Validation of designation. 598.425 Section 598.425 Housing and Urban Development Regulations Relating to Housing and Urban Development...-Designation Requirements § 598.425 Validation of designation. (a) On the basis of the periodic progress...

Design, fabrication, test, qualification and price analysis of third generation design solar cell modules. Part 1: Intermediate load module

NASA Technical Reports Server (NTRS)

Bottenberg, W. R.

1981-01-01

The updated program plan and narrative reflects the design and development work done and progress made in establishing a viable design for these modules. Design alterations from the preproduction plan are discussed based on experience gained during the preproduction phase of the program.

Mod-1 wind turbine generator analysis and design report, volume 1

NASA Technical Reports Server (NTRS)

1979-01-01

The activities leading to the completion of detail design of the MOD-1 wind turbine generator are described. Emphasis is placed on the description of the design as it finally evolved. However, the steps through which the design progressed are also traced in order to understand the major design decisions.

Membrane Transfer Phenomena (MTP)

NASA Technical Reports Server (NTRS)

Mason, Larry

1996-01-01

Progress has been made in several areas of the definition, design, and development of the Membrane Transport Apparatus (MTA) instrument and associated sensors and systems. Progress is also reported in the development of software modules for instrument control, experimental image and data acquisition, and data analysis.

Student Progress to Graduation in New York City High Schools. Part II: Student Achievement as "Stock" and "Flow"--Reimagining Early Warning Systems for At-Risk Students

ERIC Educational Resources Information Center

Fairchild, Susan; Carrino, Gerard; Gunton, Brad; Soderquist, Chris; Hsiao, Andrew; Donohue, Beverly; Farrell, Timothy

2012-01-01

New Visions for Public Schools has leveraged student-level data to help schools identify at-risk students, designed metrics to capture student progress toward graduation, developed data tools and reports that visualize student progress at different levels of aggregation for different audiences, and implemented real-time data systems for educators.…

Auditory skills, language development, and adaptive behavior of children with cochlear implants and additional disabilities

PubMed Central

Beer, Jessica; Harris, Michael S.; Kronenberger, William G.; Holt, Rachael Frush; Pisoni, David B.

2012-01-01

Objective The objective of this study was to evaluate the development of functional auditory skills, language, and adaptive behavior in deaf children with cochlear implants (CI) who also have additional disabilities (AD). Design A two-group, pre-test versus post-test design was used. Study sample Comparisons were made between 23 children with CIs and ADs, and an age-matched comparison group of 23 children with CIs without ADs (No-AD). Assessments were obtained pre-CI and within 12 months post-CI. Results All but two deaf children with ADs improved in auditory skills using the IT-MAIS. Most deaf children in the AD group made progress in receptive but not expressive language using the Preschool Language Scale, but their language quotients were lower than the No-AD group. Five of eight children with ADs made progress in daily living skills and socialization skills; two made progress in motor skills. Children with ADs who did not make progress in language, did show progress in adaptive behavior. Conclusions Children with deafness and ADs made progress in functional auditory skills, receptive language, and adaptive behavior. Expanded assessment that includes adaptive functioning and multi-center collaboration is recommended to best determine benefits of implantation in areas of expected growth in this clinical population. PMID:22509948

Experimental procedure for measuring and comparing head-neck-trunk posture and movements caused by different progressive addition lens designs.

PubMed

Mateo, B; Porcar-Seder, R; Solaz, J S; Dürsteler, J C

2010-07-01

This study demonstrates that appropriate measurement procedures can detect differences in head movement in a near reading task when using three different progressive addition lenses (PALs). The movements were measured using an anatomical reference system with a biomechanical rationale. This reference system was capable of representing rotations for comparing head flexion relative to trunk, head flexion relative to neck, head rotation relative to trunk and trunk flexion. The subject sample comprised 31 volunteers and three PAL designs with different viewing zones were selected. Significant differences were found between the lenses for three of the seven movement parameters examined. The differences occurred for both vertical and horizontal head movements and could be attributed to aspects of the PAL design. The measurement of the complete kinematic trunk-neck-head chain improved the number of differences that were found over those in previous studies. STATEMENT OF RELEVANCE: The study proposes a methodology based on a biomechanical rationale able to differentiate head-neck-trunk posture and movements caused by different progressive addition lens designs with minimum invasiveness. This methodology could also be applied to analyse the ergonomics of other devices that restrict the user's field of view, such as helmets, personal protective equipment or helmet-mounted displays for pilots. This analysis will allow designers to optimise designs offering higher comfort and performance.

SPod Progress Summary Slides | Science Inventory | US EPA

EPA Pesticide Factsheets

This presentation describes the draft “open source” design package for the SPod fenceline sensor. The SPod is a low cost, solar-powered system that combines wind field and air pollutant concentration measurements to detect emission plumes and help locate the source of emissions. The current design works only in “near-fenceline” applications where localized source emission plumes may be present. The SPod uses data analysis software (described elsewhere) to separate baseline drift from the plume signal of interest. This software is necessary for proper operation of the SPod. Because the SPod is designed to detect source emissions plumes, it is not useful for ambient applications large distances away from sources. The current SPod detects a subset of air pollutants that can be ionized with a 10.6 eV photoionization detector (PID). In the future, other air pollutant sensors may be used. The purpose of this presentation and related postings is to advance design concepts in the low-cost fenceline sensor area with any interested parties. The SPod is a work in progress with continued advances incorporated on an ongoing basis. This document is posted on an EPA share drive along with other information that describes the use operation and limitations of the SPod. These slides summarize the SPod design, purpose, and progress as of June, 2016. These slides will be posted on the EPA SPod Share Site along with design information and other materials that communicat

Designing proteins for therapeutic applications.

PubMed

Lazar, Greg A; Marshall, Shannon A; Plecs, Joseph J; Mayo, Stephen L; Desjarlais, John R

2003-08-01

Protein design is becoming an increasingly useful tool for optimizing protein drugs and creating novel biotherapeutics. Recent progress includes the engineering of monoclonal antibodies, cytokines, enzymes and viral fusion inhibitors.

The DIAN-TU Next Generation Alzheimer’s prevention trial: adaptive design and disease progression model

PubMed Central

Bateman, Randall J.; Benzinger, Tammie L.; Berry, Scott; Clifford, David B.; Duggan, Cynthia; Fagan, Anne M.; Fanning, Kathleen; Farlow, Martin R.; Hassenstab, Jason; McDade, Eric M.; Mills, Susan; Paumier, Katrina; Quintana, Melanie; Salloway, Stephen P.; Santacruz, Anna; Schneider, Lon S.; Wang, Guoqiao; Xiong, Chengjie

2016-01-01

INTRODUCTION The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer’s disease in autosomal dominant Alzheimer’s disease (ADAD) families. With completion of enrollment of the first two drug arms, the DIAN-TU now plans to add new drugs to the platform, designated as the Next Generation Prevention Trial (NexGen). METHODS In collaboration with ADAD families, philanthropic organizations, academic leaders, the DIAN-TU Pharma Consortium, the NIH, and regulatory colleagues, the DIAN-TU developed innovative clinical study designs for the DIAN-TU NexGen trial. RESULTS Our expanded trials toolbox consists of a Disease Progression Model for ADAD, primary endpoint DIAN-TU cognitive performance composite, biomarker development, self-administered cognitive assessments, adaptive dose adjustments, and blinded data collection through the last participant completion. CONCLUSION These steps represent elements to improve efficacy of the adaptive platform trial and a continued effort to optimize prevention and treatment trials in ADAD. PMID:27583651

Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies.

PubMed

Avery, Kerry N L; Williamson, Paula R; Gamble, Carrol; O'Connell Francischetto, Elaine; Metcalfe, Chris; Davidson, Peter; Williams, Hywel; Blazeby, Jane M

2017-02-17

Designing studies with an internal pilot phase may optimise the use of pilot work to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed decision or 'progression' criteria at the juncture between the internal pilot and main trial phases provides a valuable opportunity to evaluate the likely success of the main trial and optimise its design or, if necessary, to make the decision not to proceed with the main trial. Guidance on the appropriate selection and application of progression criteria is, however, lacking. This paper outlines the key issues to consider in the optimal development and review of operational progression criteria for RCTs with an internal pilot phase. A structured literature review and exploration of stakeholders' opinions at a Medical Research Council (MRC) Hubs for Trials Methodology Research workshop. Key stakeholders included triallists, methodologists, statisticians and funders. There is considerable variation in the use of progression criteria for RCTs with an internal pilot phase, although 3 common issues predominate: trial recruitment, protocol adherence and outcome data. Detailed and systematic reporting around the decision-making process for stopping, amending or proceeding to a main trial is uncommon, which may hamper understanding in the research community about the appropriate and optimal use of RCTs with an internal pilot phase. 10 top tips for the development, use and reporting of progression criteria for internal pilot studies are presented. Systematic and transparent reporting of the design, results and evaluation of internal pilot trials in the literature should be encouraged in order to facilitate understanding in the research community and to inform future trials. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Eighth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, Part 2

NASA Technical Reports Server (NTRS)

Starnes, James H., Jr. (Compiler); Bohon, Herman L. (Compiler); Garzon, Sherry B. (Compiler)

1990-01-01

Papers presented at the conference are compiled. The conference provided a forum for the scientific community to exchange composite structures design information and an opportunity to observe recent progress in composite structures design and technology. Part 2 contains papers related to the following subject areas: the application in design; methodology in design; and reliability in design.

Green Innovation Design of Products under the Perspective of Sustainable Development

NASA Astrophysics Data System (ADS)

yi-fei, Guo

2017-01-01

with the continuous development and progress of productivity, product design spans with the age now and forms a diversified formation. But when there is a progress of science and technology, the speed of consumption of resources is also increasing, the relationship between mankind and the nature further worsens, resources will be exhausted, pollution is increasingly serious and shocking public nuisance events occur frequently. People pay more attention to the environment due to the harms to the nature caused by the development of industry, science and technology. Nowadays, people have clearly recognized the important role of design in environmental protection. The ecological research on constructing a new aesthetic relationship between human and nature has drawn wide attention from all circles of the society. Green innovation design has become the focus of global concern.

Analyzing compound and project progress through multi-objective-based compound quality assessment.

PubMed

Nissink, J Willem M; Degorce, Sébastien

2013-05-01

Compound-quality scoring methods designed to evaluate multiple drug properties concurrently are useful to analyze and prioritize output from drug-design efforts. However, formalized multiparameter optimization approaches are not widely used in drug design. We rank molecules synthesized in drug-discovery projects using simple and aggregated desirability functions reflecting medicinal chemistry 'rules'. Our quality score deals transparently with missing data, a key requirement in drug-hunting projects where data availability is often limited. We further estimate confidence in the interpretation of such a compound-quality measure. Scores and associated confidences provide systematic insight in the quality of emerging chemical equity. Tracking quality of synthetic output over time yields valuable insight into the progress of drug-design teams, with potential applications in risk and resource management of a drug portfolio.

Growth through Levels

ERIC Educational Resources Information Center

Thissen, David

2015-01-01

In "Using Learning Progressions to Design Vertical Scales that Support Coherent Inferences about Student Growth" (hereafter ULR), Briggs and Peck suggest that learning progressions could be used as the basis of vertical scales with naturally benchmarked descriptions of student proficiency. They propose and provide a single example of a…

24 CFR 598.420 - Periodic progress determinations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES URBAN EMPOWERMENT ZONES: ROUND TWO AND THREE... evaluate the progress of implementation of the strategic plan in each designated Empowerment Zone on the basis of available information. HUD also may commission evaluations of the Empowerment Zone program as a...

Successful Web Learning Environments: New Design Guidelines.

ERIC Educational Resources Information Center

Martinez, Margaret

The Web offers the perfect technology and environment for precision learning because learners can be uniquely identified, relevant content can be specifically personalized, and subsequent response and progress can be monitored, supported, and assessed. Technologically, researchers are making rapid progress realizing the personalized learning dream…

Designing the Balloon Experimental Twin Telescope for Infrared Interferometry

NASA Technical Reports Server (NTRS)

Rinehart, Stephen

2011-01-01

While infrared astronomy has revolutionized our understanding of galaxies, stars, and planets, further progress on major questions is stymied by the inescapable fact that the spatial resolution of single-aperture telescopes degrades at long wavelengths. The Balloon Experimental Twin Telescope for Infrared Interferometry (BETTII) is an 8-meter boom interferometer to operate in the FIR (30-90 micron) on a high altitude balloon. The long baseline will provide unprecedented angular resolution (approx. 5") in this band. In order for BETTII to be successful, the gondola must be designed carefully to provide a high level of stability with optics designed to send a collimated beam into the cryogenic instrument. We present results from the first 5 months of design effort for BETTII. Over this short period of time, we have made significant progress and are on track to complete the design of BETTII during this year.

[Design and research progress of zero profile cervical Interbody cage].

PubMed

Zhu, Jia; Wang, Song; Liao, Zhenhua; Liu, Weiqiang

2017-02-01

Zero profile cervical interbody cage is an improvement of traditional fusion products and necessary supplement of emerging artificial intervertebral disc products. When applied in Anterior Cervical Decompression Fusion(ACDF), zero profile cervical interbody cage can preserve the advantages of traditional fusion and reduce the incidence of postoperative complications. Moreover, zero profile cervical interbody cage can be applied under the tabu symptoms of Artificial Cervical Disc Replacement(ACDR). This article summarizes zero profile interbody cage products that are commonly recognized and widely used in clinical practice in recent years, and reviews the progress of structure design and material research of zero profile cervical interbody cage products. Based on the latest clinical demands and research progress, this paper also discusses the future development directions of zero profile interbody cage.

Content addressable memory project

NASA Technical Reports Server (NTRS)

Hall, Josh; Levy, Saul; Smith, D.; Wei, S.; Miyake, K.; Murdocca, M.

1991-01-01

The progress on the Rutgers CAM (Content Addressable Memory) Project is described. The overall design of the system is completed at the architectural level and described. The machine is composed of two kinds of cells: (1) the CAM cells which include both memory and processor, and support local processing within each cell; and (2) the tree cells, which have smaller instruction set, and provide global processing over the CAM cells. A parameterized design of the basic CAM cell is completed. Progress was made on the final specification of the CPS. The machine architecture was driven by the design of algorithms whose requirements are reflected in the resulted instruction set(s). A few of these algorithms are described.

Progress in the RAMI analysis of a conceptual LHCD system for DEMO

NASA Astrophysics Data System (ADS)

Mirizzi, F.

2014-02-01

Reliability, Availability, Maintainability and Inspectability (RAMI) concepts and techniques, that acquired great importance during the first manned space missions, have been progressively extended to industrial, scientific and consumer equipments to assure them satisfactory performances and lifetimes. In the design of experimental facilities, like tokamaks, mainly aimed at demonstrating validity and feasibility of scientific theories, RAMI analysis has been often left aside. DEMO, the future prototype fusion reactors, will be instead designed for steadily delivering electrical energy to commercial grids, so that the RAMI aspects will assume an absolute relevance since their initial design phases. A preliminary RAMI analysis of the LHCD system for the conceptual EU DEMO reactor is given in the paper.

Progress Report for a New Cryogenic Sapphire Oscillator

NASA Technical Reports Server (NTRS)

Wang, Rabi T.; Dick, G. J.; Tjoelker, R. L.

2006-01-01

We present design progress and subsystem test results for a new short-term frequency standard, the Voltage Controlled Sapphire Oscillator (VCSO). Included are sapphire resonator and coupling design, cryocooler environmental sensitivity tests, Q measurement results, and turnover temperature results. A previous report presented history of the design related to resonator frequency and frequency compensation [1]. Performance goals are a frequency stability of 1x10(exp -14) (1 second less than or equal to (tau) less than or equal to 100 seconds) and two years or more continuous operation. Long-term operation and small size are facilitated by use of a small Stirling cryo-cooler (160W wall power) with an expected 5 year life.

Powering Exploration: The Ares I Crew Launch Vehicle and Ares V Cargo Launch Vehicle

NASA Technical Reports Server (NTRS)

Cook, Stephen A.

2008-01-01

The National Aeronautics and Space Administration (NASA)'s Constellation Program is depending on the Ares Projects to deliver the crew and cargo launch capabilities needed to send human explorers to the Moon and beyond. The Ares Projects continue to make progress toward design, component testing, and early flight testing of the Ares I crew launch vehicle, as well as early design work for Ares V cargo launch vehicle. Ares I and Ares V will form the core space launch capabilities the United States needs to continue its pioneering tradition as a spacefaring nation. This paper will discuss programmatic, design, fabrication, and testing progress toward building these new launch vehicles.

Refining a learning progression of energy

NASA Astrophysics Data System (ADS)

Yao, Jian-Xin; Guo, Yu-Ying; Neumann, Knut

2017-11-01

This paper presents a revised learning progression for the energy concept and initial findings on diverse progressions among subgroups of sample students. The revised learning progression describes how students progress towards an understanding of the energy concept along two progress variables identified from previous studies - key ideas about energy and levels of conceptual development. To assess students understanding with respect to the revised learning progression, we created a specific instrument, the Energy Concept Progression Assessment (ECPA) based on previous work on assessing students' understanding of energy. After iteratively refining the instrument in two pilot studies, the ECPA was administered to a total of 4550 students (Grades 8-12) from schools in two districts in a major city in Mainland China. Rasch analysis was used to examine the validity of the revised learning progression and explore factors explaining different progressions. Our results confirm the validity of the four conceptual development levels. In addition, we found that although following a similar progression pattern, students' progression rate was significantly influenced by environmental factors such as school type. In the discussion of our findings, we address the non-linear and complex nature of students' progression in understanding energy. We conclude with illuminating our research's implication for curriculum design and energy teaching.

High Stakes Assessment: A Local District Perspective.

ERIC Educational Resources Information Center

Oldham, Ben R.

The Kentucky Education Reform Act legislated by the 1990 General Assembly created a high-stakes school performance accountability system to monitor the progress of implementation. One major component of the accountability system is a schedule of consequences designed to reward those schools making sufficient progress in improving student…

Automobile Course. Progress Record and Theory Outline.

ERIC Educational Resources Information Center

Connecticut State Dept. of Education, Hartford. Div. of Vocational-Technical Schools.

This combination progress record and course outline is designed for use by individuals teaching a course in automobile repair. Included among the topics addressed in the course are the following: shop safety, engines, fuel and exhaust systems, electrical systems, crankcase lubrication systems, cooling systems, power transmission systems, steering…

26 CFR 1.46-5 - Qualified progress expenditures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Qualified progress expenditures. 1.46-5 Section 1... planning, designing, preparing blueprints, exploring, or securing financing. (ii) The determination of the... construction also does not include research and development activities in a laboratory or experimental setting...

26 CFR 1.46-5 - Qualified progress expenditures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Qualified progress expenditures. 1.46-5 Section 1... planning, designing, preparing blueprints, exploring, or securing financing. (ii) The determination of the... construction also does not include research and development activities in a laboratory or experimental setting...

26 CFR 1.46-5 - Qualified progress expenditures.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 1 2014-04-01 2013-04-01 true Qualified progress expenditures. 1.46-5 Section 1... planning, designing, preparing blueprints, exploring, or securing financing. (ii) The determination of the... construction also does not include research and development activities in a laboratory or experimental setting...

Advancing High-Quality Literacy Research in Juvenile Justice: Methodological and Practical Considerations

ERIC Educational Resources Information Center

Houchins, David E.; Jolivette, Kristine; Shippen, Margaret E.; Lambert, Richard

2010-01-01

Special education researchers have made noteworthy progress toward conceptualizing literacy research questions, designing quality studies, and disseminating the results of their research. These advancements have been made through the establishment and refinement of quality research indicators. Unfortunately, this progress has mostly eluded the…

Annual Reports Regarding Progress in Developing a Dredged Material Management Plan for the Long Island Sound Region

EPA Pesticide Factsheets

The site designation for the Western and Central Long Island Sound disposal sites requires the completion of a Dredged Material Management Plan (DMMP) and EPA to conduct an annual review of progress toward completion of the DMMP.

Remote Science Operation Center research

NASA Technical Reports Server (NTRS)

Banks, P. M.

1986-01-01

Progress in the following areas is discussed: the design, planning and operation of a remote science payload operations control center; design and planning of a data link via satellite; and the design and prototyping of an advanced workstation environment for multi-media (3-D computer aided design/computer aided engineering, voice, video, text) communications and operations.

The Importance of Design Thinking for Technological Literacy: A Phenomenological Perspective

ERIC Educational Resources Information Center

Wells, Alastair

2013-01-01

"We know that progress depends on discovery, inventions, creativity and design, but we have simply supposed that it happens anyway," de Bono (1999 p. 43). Technology education is ostensibly a foundation for future designers and creative thinking. However evidence of good design or creative thinking in outcomes displayed in school…

MONTHLY PROGRESS REPORT ON THE FEASIBILITY AND DESIGN STUDY FOR COLLECTIVE PROTECTION EQUIPMENT FOR THE AN/MSG-4 SYSTEM. PHASEIA. Technical Report, April 15 to May 30, 1962 (1st Report). Financial Report, April 15 to May 30, 1962 (1st Report). GSG Report No. 1663.00/54

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glaser, J.

1962-06-19

Initial efforts devoted to development of layout drawings of the protective equipment from which detailed fabrication drawings are to be established are reported. Collective protection equipment design progress is reported on 400- and 800-cfm filter units and on protective entrances for shelters and vehicles. (J.R.D.)

Creationism and intelligent design are incompatible with scientific progress: A response to Shanta and Vêdanta.

PubMed

Caetano-Anollés, Gustavo

2016-01-01

In a recent opinion paper, B.K. Shanta claims science leaves no room for the subjective aspect of consciousness, and in doing so, attacks both origin of life and evolutionary research. He claims Vêdanta, one of the 6 orthodox schools of Hindu philosophy, offers an explanation: "the origin of everything material and nonmaterial is sentient and absolute." Here I discuss how the pseudoscience of these creationist views, which are aligned with Intelligent Design, are incompatible with scientific progress and should not be published in scientific journals.

Progress in performance enhancement methods for capacitive silicon resonators

NASA Astrophysics Data System (ADS)

Van Toan, Nguyen; Ono, Takahito

2017-11-01

In this paper, we review the progress in recent studies on the performance enhancement methods for capacitive silicon resonators. We provide information on various fabrication technologies and design considerations that can be employed to improve the performance of capacitive silicon resonators, including low motional resistance, small insertion loss, and high quality factor (Q). This paper contains an overview of device structures and working principles, fabrication technologies consisting of hermetic packaging, deep reactive-ion etching and neutral beam etching, and design considerations including mechanically coupled, movable electrode structures and piezoresistive heat engines.

Development of a Dynamically Configurable, Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation

NASA Technical Reports Server (NTRS)

Afjeh, Abdollah A.; Reed, John A.

2003-01-01

The following reports are presented on this project:A first year progress report on: Development of a Dynamically Configurable,Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation; A second year progress report on: Development of a Dynamically Configurable, Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation; An Extensible, Interchangeable and Sharable Database Model for Improving Multidisciplinary Aircraft Design; Interactive, Secure Web-enabled Aircraft Engine Simulation Using XML Databinding Integration; and Improving the Aircraft Design Process Using Web-based Modeling and Simulation.

Racial progress as threat to the status hierarchy: implications for perceptions of anti-White bias.

PubMed

Wilkins, Clara L; Kaiser, Cheryl R

2014-02-01

In three studies, we examined how racial progress affects Whites' perceptions of anti-White bias. When racial progress was chronically (Study 1) and experimentally (Study 2) salient, Whites who believed the current U.S. status hierarchy was legitimate were more likely to report that Whites were victims of racial discrimination. In contrast, Whites who perceived the current status system as illegitimate were unaffected by the salience of racial progress. The results of Study 3 point to the role of threat in explaining these divergent reactions to racial progress. When self-affirmed, Whites who perceived the status hierarchy as legitimate no longer showed increased perceptions of anti-White bias when confronted with evidence of racial progress. Implications for policies designed to remedy social inequality are discussed.

"Filming in Progress": New Spaces for Multimodal Designing

ERIC Educational Resources Information Center

Mills, Kathy A.

2010-01-01

Global trends call for new research to investigate multimodal designing mediated by new technologies and the implications for classroom spaces. This article addresses the relationship between new technologies, students' multimodal designing, and the social production of classroom spaces. Multimodal semiotics and sociological principles are applied…

Recommendations for Benchmarking Preclinical Studies of Nanomedicines.

PubMed

Dawidczyk, Charlene M; Russell, Luisa M; Searson, Peter C

2015-10-01

Nanoparticle-based delivery systems provide new opportunities to overcome the limitations associated with traditional small-molecule drug therapy for cancer and to achieve both therapeutic and diagnostic functions in the same platform. Preclinical trials are generally designed to assess therapeutic potential and not to optimize the design of the delivery platform. Consequently, progress in developing design rules for cancer nanomedicines has been slow, hindering progress in the field. Despite the large number of preclinical trials, several factors restrict comparison and benchmarking of different platforms, including variability in experimental design, reporting of results, and the lack of quantitative data. To solve this problem, we review the variables involved in the design of preclinical trials and propose a protocol for benchmarking that we recommend be included in in vivo preclinical studies of drug-delivery platforms for cancer therapy. This strategy will contribute to building the scientific knowledge base that enables development of design rules and accelerates the translation of new technologies. ©2015 American Association for Cancer Research.

Perspective: Recommendations for benchmarking pre-clinical studies of nanomedicines

PubMed Central

Dawidczyk, Charlene M.; Russell, Luisa M.; Searson, Peter C.

2015-01-01

Nanoparticle-based delivery systems provide new opportunities to overcome the limitations associated with traditional small molecule drug therapy for cancer, and to achieve both therapeutic and diagnostic functions in the same platform. Pre-clinical trials are generally designed to assess therapeutic potential and not to optimize the design of the delivery platform. Consequently, progress in developing design rules for cancer nanomedicines has been slow, hindering progress in the field. Despite the large number of pre-clinical trials, several factors restrict comparison and benchmarking of different platforms, including variability in experimental design, reporting of results, and the lack of quantitative data. To solve this problem, we review the variables involved in the design of pre-clinical trials and propose a protocol for benchmarking that we recommend be included in in vivo pre-clinical studies of drug delivery platforms for cancer therapy. This strategy will contribute to building the scientific knowledge base that enables development of design rules and accelerates the translation of new technologies. PMID:26249177

Quantifying Disease Progression in Amyotrophic Lateral Sclerosis

PubMed Central

Simon, Neil G; Turner, Martin R; Vucic, Steve; Al-Chalabi, Ammar; Shefner, Jeremy; Lomen-Hoerth, Catherine; Kiernan, Matthew C

2014-01-01

Amyotrophic lateral sclerosis (ALS) exhibits characteristic variability of onset and rate of disease progression, with inherent clinical heterogeneity making disease quantitation difficult. Recent advances in understanding pathogenic mechanisms linked to the development of ALS impose an increasing need to develop strategies to predict and more objectively measure disease progression. This review explores phenotypic and genetic determinants of disease progression in ALS, and examines established and evolving biomarkers that may contribute to robust measurement in longitudinal clinical studies. With targeted neuroprotective strategies on the horizon, developing efficiencies in clinical trial design may facilitate timely entry of novel treatments into the clinic. PMID:25223628

Educational Model for Social Service Administration and Management. Summary Progress Report.

ERIC Educational Resources Information Center

Wright, Marjorie Brown

This paper constitutes a summary progress report on a short-term training course designed to provide social work bachelor's degree practitioners with the knowledge and skills necessary for administrative and managerial positions. Increasingly, social work graduates have reported moving into social service administration and managerial positions…

Framework for Designing Context-Aware Learning Systems

ERIC Educational Resources Information Center

Tortorella, Richard A. W.; Kinshuk; Chen, Nian-Shing

2018-01-01

Today people learn in many diverse locations and contexts, beyond the confines of classical brick and mortar classrooms. This trend is ever increasing, progressing hand-in-hand with the progress of technology. Context-aware learning systems are systems which adapt to the learner's context, providing tailored learning for a particular learning…

Evaluation of the National Assessment of Educational Progress. Study Reports

ERIC Educational Resources Information Center

Buckendahl, Chad W.; Davis, Susan L.; Plake, Barbara S.; Sireci, Stephen G.; Hambleton, Ronald K.; Zenisky, April L.; Wells, Craig S.

2009-01-01

The "Evaluation of the National Assessment of Educational Progress: Study Reports" describes the special studies that comprised the design of the evaluation. In the Final Report, the authors presented a practical discussion of the evaluation studies to its primary, intended audience, namely policymakers. On this accompanying CD, readers…

Reduced posting and marking of flight progress strips for en route air traffic control : final report.

DOT National Transportation Integrated Search

2000-02-01

The new Display System Replacement (DSR) being implemented in air route traffic control centers (ARTCCs) will allow the data-side controller less room to post Flight Progress Strips (FPSs). We tested a new FPS marking and posting procedure designed t...

Signal and Communications. Progress Record and Theory Outline.

ERIC Educational Resources Information Center

Connecticut State Dept. of Education, Hartford. Div. of Vocational-Technical Schools.

This combination progress record and course outline is designed for use by individuals teaching a course in signals and communications. Included among the topics addressed in the course are the following: matter, the nature of electricity, dry cells and batteries, Ohm's law, power, magnetism, measurement instruments, Kirchoff's laws,…

Rock mechanics. Practical use in civil engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murakami, S.

1985-01-01

Because of the recent development of computer technology, a systematic analysis of the stability and behavior of rock is gradually progressing as rock mechanics. Although its progress is still behind that of engineering geology, the book aims to contribute to the systematization of the subject. Examples of design are given.

Nuclear waste management. Semiannual progress report, October 1982-March 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chikalla, T.D.; Powell, J.A.

1983-06-01

This document is one of a series of technical progress reports designed to report radioactive waste management programs at the Pacific Northwest Laboratory. Accomplishments in the following programs are reported: waste stabilization; Materials Characterization Center; waste isolation; low-level waste management; remedial action; and supporting studies.

Africa's Agenda for Action: Reform Policies, Renew Progress.

ERIC Educational Resources Information Center

Johanson, Richard K., Ed.

1987-01-01

Unprecedented population growth and mounting fiscal austerity in Africa is causing a decline in the significant increases in educational progress, especially as measured by the median literacy rate, which were made between 1962 and 1985. Planning and implementation of educational programs carefully designed to effect economic growth is one path…

46 CFR 172.245 - Survival conditions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... conditions. A vessel is presumed to survive assumed damage if it meets the following conditions in the final..., and trim must be below the lower edge of an opening through which progressive flooding may take place... inches (50 mm) when the vessel is in the equilibrium position. (e) Progressive flooding. In the design...

46 CFR 172.245 - Survival conditions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... conditions. A vessel is presumed to survive assumed damage if it meets the following conditions in the final..., and trim must be below the lower edge of an opening through which progressive flooding may take place... inches (50 mm) when the vessel is in the equilibrium position. (e) Progressive flooding. In the design...

46 CFR 172.245 - Survival conditions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... conditions. A vessel is presumed to survive assumed damage if it meets the following conditions in the final..., and trim must be below the lower edge of an opening through which progressive flooding may take place... inches (50 mm) when the vessel is in the equilibrium position. (e) Progressive flooding. In the design...

Precision Sheet Metal. Progress Record and Theory Outline.

ERIC Educational Resources Information Center

Connecticut State Dept. of Education, Hartford. Div. of Vocational-Technical Schools.

This combination progress record and course outline is designed for use by individuals teaching a course in precision sheet metal. Included among the topics addressed in the course are the following: employment opportunities in metalworking, measurement and layout, orthographic projection, precision sheet metal drafting, simple layout, hand tools,…

MIT-CSR XIS Project

NASA Technical Reports Server (NTRS)

1998-01-01

This report outlines the proposers' progress toward MIT's contribution to the X-Ray Imaging Spectrometer (XIS) experiment on the Japanese ASTRO-E mission. The report discusses electrical system design, mechanical system design, and ground support equipment.

Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design.

PubMed

Kazi, Ada; Chuah, Candy; Majeed, Abu Bakar Abdul; Leow, Chiuan Herng; Lim, Boon Huat; Leow, Chiuan Yee

2018-03-12

Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, antibody design and vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent advances in the field of immunological bioinformatics have provided feasible tools which can be used to lessen the time and cost required for vaccine and antibody development. This approach allows the selection of immunogenic regions from the pathogen genomes. The ideal regions could be developed as potential vaccine candidates to trigger protective immune responses in the hosts. At present, epitope-based vaccines are attractive concepts which have been successfully trailed to develop vaccines which target rapidly mutating pathogens. In this article, we provide an overview of the current progress of immunoinformatics and their applications in the vaccine design, immune system modeling and therapeutics.

Design and application of electromechanical actuators for deep space missions

NASA Technical Reports Server (NTRS)

Haskew, Tim A.; Wander, John

1994-01-01

This progress report documents research and development efforts performed from August 16, 1993 through August 15, 1994 on NASA Grant NAG8-240, 'Design and Application of Electromechanical Actuators for Deep Space Missions.' Since the submission of our last progress report in February 1994, our efforts have been almost entirely focused on final construction of the test stand and experiment design. Hence, this report is dedicated solely to these topics. However, updates on our research personnel and our health monitoring and fault management efforts are provided in this summary. Following this executive summary are two report sections. The first is devoted to the motor drive being constructed for the test stand. The thrust of the next section is the mechanical and hydraulic design and construction based on the planned experimental requirements. Following both major sections are three appendices.

Failure: A Source of Progress in Maintenance and Design

NASA Astrophysics Data System (ADS)

Chaïb, R.; Taleb, M.; Benidir, M.; Verzea, I.; Bellaouar, A.

This approach, allows using the failure as a source of progress in maintenance and design to detect the most critical components in equipment, to determine the priority order maintenance actions to lead and direct the exploitation procedure towards the most penalizing links in this equipment, even define the necessary changes and recommendations for future improvement. Thus, appreciate the pathological behaviour of the material and increase its availability, even increase its lifespan and improve its future design. In this context and in the light of these points, the failures are important in managing the maintenance function. Indeed, it has become important to understand the phenomena of failure and degradation of equipments in order to establish an appropriate maintenance policy for the rational use of mechanical components and move to the practice of proactive maintenance [1], do maintenance at the design [2].

The optics of occupational progressive lenses.

PubMed

Sheedy, James E; Hardy, Raymond F

2005-08-01

Occupational progressive lenses (OPLs) utilize progressive power optics and are designed primarily to meet near and intermediate viewing needs such as working at a computer workstation for presbyopic patients. OPLs are fabricated to have the prescribed near power in the lower part of the lens and the power in the upper portion of the lens is determined by the amount of power "degression" (decrease in plus power) relative to the near power. Independent measurements of the optical characteristics of these lenses have not been reported previously. Manufacturers of 7 different OPL designs provided sample lenses for a patient with +2.50 D add that were measured with a Rotlex Class Plus lens analyzer (Rotlex Inc., Israel). Power measurements were normalized to the location specified by the manufacturer, and the vertical location of each lens was normalized to pupil center based on manufacturer fitting guidelines. Large optical differences exist among the OPL designs. The results show clear differences between the designs in terms of the add powers, their vertical location, and zone width. The size and location of the near, near-intermediate, far-intermediate, and far viewing zones were determined. The literature and clinical experience support that OPLs are successful at meeting the computer, general office, and other intermediate viewing distance needs of many patients. However, because of the large differences in the several OPL designs, patient success can likely be enhanced by selecting the design that best suits his or her viewing needs.

The effect of progressive resistance training on aerobic fitness and strength in adults with coronary heart disease: A systematic review and meta-analysis of randomised controlled trials.

PubMed

Hollings, Matthew; Mavros, Yorgi; Freeston, Jonathan; Fiatarone Singh, Maria

2017-08-01

Design We aimed to evaluate the effect of progressive resistance training on cardiorespiratory fitness and muscular strength in coronary heart disease, when compared to control or aerobic training, and when combined with aerobic training. Secondary aims were to evaluate the safety and efficacy of progressive resistance training on other physiological and clinical outcomes. Methods and results Electronic databases were searched from inception until July 2016. Designs included progressive resistance training vs control, progressive resistance training vs aerobic training, and combined training vs aerobic training. From 268,778 titles, 34 studies were included (1940 participants; 71.9% male; age 60 ± 7 years). Progressive resistance training was more effective than control for lower (standardized mean difference 0.57, 95% confidence interval (0.17-0.96)) and upper (1.43 (0.73-2.13)) body strength. Aerobic fitness improved similarly after progressive resistance training (16.9%) or aerobic training (21.0%); (standardized mean difference -0.13, 95% confidence interval (-0.35-0.08)). Combined training was more effective than aerobic training for aerobic fitness (0.21 (0.09-0.34), lower (0.62 (0.32-0.92)) and upper (0.51 (0.27-0.74)) body strength. Twenty studies reported adverse event information, with five reporting 64 cardiovascular complications, 63 during aerobic training. Conclusion Isolated progressive resistance training resulted in an increase in lower and upper body strength, and improved aerobic fitness to a similar degree as aerobic training in coronary heart disease cohorts. Importantly, when progressive resistance training was added to aerobic training, effects on both fitness and strength were enhanced compared to aerobic training alone. Reporting of adverse events was poor, and clinical gaps were identified for women, older adults, high intensity progressive resistance training and long-term outcomes, warranting future trials to confirm safety and effectiveness.

Peripheral Design of Progressive Addition Lenses and the Lag of Accommodation in Myopes.

PubMed

Schilling, Tim; Ohlendorf, Arne; Varnas, Saulius R; Wahl, Siegfried

2017-07-01

Insufficient accommodative response is assumed to result in myopia progression. We have investigated if the accommodative lag in myopes is different between a single vision lens (SVL) and the progressive addition lens PAL 2, clinically trialled for its ability to reduce progression of myopia, and if there exist differences in accommodative lag between PAL 2 and other PALs with the same addition power (+1.50 D). The influence of spherical SVL and four different designs of PALs that differ in the near zone width (PAL 1) or that have different signs and magnitude of horizontal gradients of mean power adjacent to their near vision zones (PAL 3 and PAL 4) on the accommodative response was investigated for different near viewing distances (40, 33, and 25 cm) in 31 subjects, aged 18 to 25 years. The SVL correction resulted in insufficient accommodative response for the near object viewing distances tested. PAL 2 did significantly reduce accommodative lag for all near object distances tested. The PAL design with a more negative horizontal mean power gradient (PAL 4) provided a lower lag of accommodation when compared with PAL 2 at the shortest object distance of 25 cm (P = 0.03) and was able to reduce the lag of accommodation to a level below the depth of focus for the higher near working distances tested. Designs of PAL with more negative horizontal mean power gradients are the most effective in lowering the lag of accommodation in myopes. This could make them good test candidates for myopia control applications.

Beyond Content, Deeper than Delivery: What Critique Feedback Reveals about Communication Expectations in Design Education

ERIC Educational Resources Information Center

Dannels, Deanna; Gaffney, Amy Housley; Martin, Kelly Norris

2008-01-01

In design education, the critique is a communication event in which students present their design and critics provide feedback. Presumably, the feedback gives the students information about their progress on the design. Yet critic feedback also serves a socializing function--providing students information about what it means to communicate well in…

The Prairie Valley Project: Reactions to a Transition to a Schoolwide, Multiage Elementary Classroom Design

ERIC Educational Resources Information Center

Bailey, Gregory J.; Werth, Eric P.; Allen, Donna M.; Sutherland, Leonie L.

2016-01-01

Originating from progressive educators who saw the need for student-centered educational designs rather than the traditional, single-age classroom design based on Henry Ford's assembly line, the multiage classroom design is returning as a viable alternative to the single-age classroom. The authors explored the perceptions of parents and teachers…

Progressive addition spectacle lenses: Design preferences and head movements while reading

NASA Astrophysics Data System (ADS)

Preston, Julie Lynn

In a subjective preference study, two key progressive addition lens parameters, near zone width and corridor length, were varied in a double-masked, randomized, clinical trial of 49 patients. Each subject received a complete eye examination and a new frame. Each wore 6 pairs of lenses for one week at a time and completed questionnaires relating to vision, adaptation, and satisfaction. The preferred lens was identified from the three near zone width lenses and from the three corridor length lenses. Patient characteristics were analyzed for their effect on design preference. Satisfaction ratings following a brief experience with each design were compared to ratings after one week of wear in order to ascertain the predictability of initial impressions. One lens design appeared twice in the preference trial, providing an assessment of the repeatability of the rating instrument. The lens design with the widest near zone was rated significantly lower than the other near zone width designs for nearly every question relating to vision, adaptation, and satisfaction. This lens was also least preferred of all the designs. Preferences for corridor length were evenly distributed among the three designs. Of patient characteristics, years of progressive addition lens wear and gender significantly affected design preference in this population. Initial impressions were not predictive of satisfaction after a week of wear. The rating instrument was judged to have low repeatability. In the head movement portion of the study, 18 participants from the preference study wore the three near zone width designs while reading three paragraphs of varying print size. From a 20 second recording for each of three different paragraphs with each lens, measures of head rotation and posture were collected. The amplitude of head rotation was significantly affected by print size but not by lens design. The effective zone widths on the lenses scanned by the eyes and the locations of the reading levels were calculated from the head rotation and posture data. Effective zone widths were narrower than the contour plot widths for each condition.

Status of Progress Made Toward Preliminary Design Concepts for the Inventory in Select Media for DOE-Managed HLW/SNF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matteo, Edward N.; Hardin, Ernest L.; Hadgu, Teklu

As the title suggests, this report provides a summary of the status and progress for the Preliminary Design Concepts Work Package. Described herein are design concepts and thermal analysis for crystalline and salt host media. The report concludes that thermal management of defense waste, including the relatively small subset of high thermal output waste packages, is readily achievable. Another important conclusion pertains to engineering feasibility, and design concepts presented herein are based upon established and existing elements and/or designs. The multipack configuration options for the crystalline host media pose the greatest engineering challenges, as these designs involve large, heavy wastemore » packages that pose specific challenges with respect to handling and emplacement. Defense-related Spent Nuclear Fuel (DSNF) presents issues for post-closure criticality control, and a key recommendation made herein relates to the need for special packaging design that includes neutron-absorbing material for the DSNF. Lastly, this report finds that the preliminary design options discussed are tenable for operational and post-closure safety, owing to the fact that these concepts have been derived from other published and well-studied repository designs.« less

Taking the Next Steps: The Ares I Crew Launch Vehicle and Ares V Cargo Launch Vehicle

NASA Technical Reports Server (NTRS)

Cook, Stephen A.; Vanhooser, Teresa

2008-01-01

The National Aeronautics and Space Administration (NASA)'s Constellation Program is depending on the Ares Projects Office (APO) to deliver the crew and cargo launch capabilities needed to send human explorers to the Moon, Mars, and beyond. The APO continues to make progress toward design, component testing, and early flight testing of the Ares I crew launch vehicle, as well as early design work for the Ares V cargo launch vehicle. Ares I and Ares V will form the core space launch capabilities that the United States needs to continue its pioneering tradition as a spacefaring nation (Figure 1). This paper will discuss design, fabrication, and testing progress toward building these new launch vehicles.

The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model.

PubMed

Bateman, Randall J; Benzinger, Tammie L; Berry, Scott; Clifford, David B; Duggan, Cynthia; Fagan, Anne M; Fanning, Kathleen; Farlow, Martin R; Hassenstab, Jason; McDade, Eric M; Mills, Susan; Paumier, Katrina; Quintana, Melanie; Salloway, Stephen P; Santacruz, Anna; Schneider, Lon S; Wang, Guoqiao; Xiong, Chengjie

2017-01-01

The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer's disease in autosomal dominant Alzheimer's disease (ADAD) families. With completion of enrollment of the first two drug arms, the DIAN-TU now plans to add new drugs to the platform, designated as the Next Generation (NexGen) prevention trial. In collaboration with ADAD families, philanthropic organizations, academic leaders, the DIAN-TU Pharma Consortium, the National Institutes of Health, and regulatory colleagues, the DIAN-TU developed innovative clinical study designs for the DIAN-TU NexGen prevention trial. Our expanded trial toolbox consists of a disease progression model for ADAD, primary end point DIAN-TU cognitive performance composite, biomarker development, self-administered cognitive assessments, adaptive dose adjustments, and blinded data collection through the last participant completion. These steps represent elements to improve efficacy of the adaptive platform trial and a continued effort to optimize prevention and treatment trials in ADAD. Copyright © 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Analysis for the Progressive Failure Response of Textile Composite Fuselage Frames

NASA Technical Reports Server (NTRS)

Johnson, Eric R.; Boitnott, Richard L. (Technical Monitor)

2002-01-01

A part of aviation accident mitigation is a crashworthy airframe structure, and an important measure of merit for a crashworthy structure is the amount of kinetic energy that can be absorbed in the crush of the structure. Prediction of the energy absorbed from finite element analyses requires modeling the progressive failure sequence. Progressive failure modes may include material degradation, fracture and crack growth, and buckling and collapse. The design of crashworthy airframe components will benefit from progressive failure analyses that have been validated by tests. The subject of this research is the development of a progressive failure analysis for a textile composite, circumferential fuselage frame subjected to a quasi-static, crash-type load. The test data for the frame are reported, and these data are used to develop and to validate methods for the progressive failure response.

Military Personnel Attrition and Retention: Research in Progress

DTIC Science & Technology

1981-10-01

designed to assess the relative risks of attrition among non -h.gh. school graduate Army enlistees. As a group, these individuals historically...this methodology see the Majcýhrzak paper in this volume) Research in the PlanningStaaqe Stage ’TV: Administrative Experimentation In order to derive...different research designs : 1. True experimental designs ; 2. Correlational research designs ; 3. Quasi- experimental research designs . We rejected the idea

Establishing Equivalence: Methodological Progress in Group-Matching Design and Analysis

ERIC Educational Resources Information Center

Kover, Sara T.; Atwood, Amy K.

2013-01-01

This methodological review draws attention to the challenges faced by intellectual and developmental disabilities researchers in the appropriate design and analysis of group comparison studies. We provide a brief overview of matching methodologies in the field, emphasizing group-matching designs used in behavioral research on cognition and…

RADON PREVENTION IN THE DESIGN AND CONSTRUCTION OF SCHOOLS AND OTHER LARGE BUILDINGS

EPA Science Inventory

The paper discusses radon prevention in the design and construction of schools and other large buildings. ased on studies in progress for the past 3 years, the U.S. EPA's Office of Research and Development (ORD) has started incorporating radon control measures into the design and...

Designer Babies: Eugenics Repackaged or Consumer Options?

ERIC Educational Resources Information Center

Baird, Stephen L.

2007-01-01

"Designer babies" is a term used by journalists and commentators--not by scientists--to describe several different reproductive technologies. These technologies have one thing in common: they give parents more control over what their offspring will be like. Designer babies are made possible by progress in three fields: (1) Advanced…

Scientific Arguments as Learning Artifacts: Designing for Learning from the Web with KIE.

ERIC Educational Resources Information Center

Bell, Philip; Linn, Marcia C.

2000-01-01

Examines how students use evidence, determines when they add further ideas and claims, and measures progress in understanding light propagation. Uses the Scaffolded Knowledge Integration (SKI) instructional framework for design decisions. Discusses design studies that test and elaborate on the instructional framework. (Contains 33 references.)…

Control of large flexible space structures

NASA Technical Reports Server (NTRS)

Vandervelde, W. E.

1986-01-01

Progress in robust design of generalized parity relations, design of failure sensitive observers using the geometric system theory of Wonham, computational techniques for evaluation of the performance of control systems with fault tolerance and redundancy management features, and the design and evaluation od control systems for structures having nonlinear joints are described.

Progress and prospects for an FI relevant point design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Key, M; Amendt, P; Bellei, C

The physics issues involved in scaling from sub ignition to high gain fast ignition are discussed. Successful point designs must collimate the electrons and minimize the stand off distance to avoid multi mega-joule ignition energies. Collimating B field configurations are identified and some initial designs are explored.

Shuttle Risk Progression by Flight

NASA Technical Reports Server (NTRS)

Hamlin, Teri; Kahn, Joe; Thigpen, Eric; Zhu, Tony; Lo, Yohon

2011-01-01

Understanding the early mission risk and progression of risk as a vehicle gains insights through flight is important: . a) To the Shuttle Program to understand the impact of re-designs and operational changes on risk. . b) To new programs to understand reliability growth and first flight risk. . Estimation of Shuttle Risk Progression by flight: . a) Uses Shuttle Probabilistic Risk Assessment (SPRA) and current knowledge to calculate early vehicle risk. . b) Shows impact of major Shuttle upgrades. . c) Can be used to understand first flight risk for new programs.

Cracow clean fossil fuels and energy efficiency program. Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-10-01

Since 1990 the US Department of Energy has been involved in a program aimed at reducing air pollution caused by small, coal-fired sources in Poland. The program focuses on the city of Cracow and is designed so that results will be applicable and extendable to the entire region. This report serves both as a review of the progress which has been made to date in achieving the program objectives and a summary of work still in progress.

CRACOW CLEAN FOSSIL FUELS AND ENERGY EFFICIENCY PROGRAM. PROGRESS REPORT, OCTOBER 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

PIERCE,B.

1998-10-01

Since 1990 the US Department of Energy has been involved in a program aimed at reducing air pollution caused by small, coal-fired sources in Poland. The program focuses on the city of Cracow and is designed so that results will be applicable and extendable to the entire region. This report serves both as a review of the progress which has been made to date in achieving the program objectives and a summary of work still in progress.

Progress 23 supply vehicle approach

NASA Image and Video Library

2006-10-26

ISS014-E-06544 (26 Oct. 2006) --- Backdropped by a blue and white Earth, an unpiloted Progress supply vehicle approaches the International Space Station. Progress docked to the aft port of the Zvezda Service Module at 9:29 a.m. (CDT) on Oct. 26. The spacecraft used the automated Kurs system to dock at the aft port of the Zvezda service module. Expedition 14 flight engineer Mikhail Tyurin stood by at the manual Toru docking system controls, but the automated system functioned as designed and manual intervention was not needed.

Avionics. Progress Record and Theory Outline.

ERIC Educational Resources Information Center

Connecticut State Dept. of Education, Hartford. Div. of Vocational-Technical Schools.

This combination progress record and course outline is designed for use by individuals teaching a course in avionics that is intended to prepare students for employment in the field of aerospace electronics. Included among the topics addressed in the course are the following: shop practices, aircraft and the theory of flight, electron physics,…

Independent Study in High School Chemistry: A Progress Report.

ERIC Educational Resources Information Center

DeRose, James V.

This is a progress report of an independent study program in chemistry at a senior high school. Currently in its fourth year of operation, the program is designed to provide students with individualized, self-paced instruction in college-preparatory chemistry. The author discusses the rationale for the program, the initial phases, the problems…

Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis

USDA-ARS?s Scientific Manuscript database

While animal studies found vitamin K treatment reduced vascular calcification, human data are limited. Using a case-cohort design, we determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-ethnic Study of Atherosclerosis. Serum phylloquinone (v...

Development of Career Progression Systems for Employees in the Foodservice Industry. Final Report.

ERIC Educational Resources Information Center

National Restaurant Association, Chicago, IL.

Firms representing four segments of the foodservice industry (institutional foodservice (9 jobs), commercial restaurants (19 jobs), hotel foodservice (100 jobs), and airline foodservice (10 jobs), participated in a career and training study to test the feasibility of designing and implementing career progression (c.p.) systems within these…

77 FR 75441 - Healthy Home and Lead Hazard Control Grant Programs Data Collection; Progress Reporting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-20

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5603-N-93] Healthy Home and Lead Hazard... collection is designed to provide HUD timely information on progress of Healthy Homes Demonstration Program, Healthy Homes Technical Studies Program, Lead Base paint Hazard Control program, Lead Hazard Reduction...

Progress Report 2013. Turnaround Arts Initiative

ERIC Educational Resources Information Center

Stoelinga, Sara Ray; Joyce, Katie; Silk, Yael

2013-01-01

This interim progress report provides a look at Turnaround Arts schools in their first year, including: (1) a summary of the evaluation design and research questions; (2) a preliminary description of strategies used to introduce the arts in Turnaround Arts schools; and (3) a summary of school reform indicators and student achievement data at…

Developing a Multi-Year Learning Progression for Carbon Cycling in Socio-Ecological Systems

ERIC Educational Resources Information Center

Mohan, Lindsey; Chen, Jing; Anderson, Charles W.

2009-01-01

This study reports on our steps toward achieving a conceptually coherent and empirically validated learning progression for carbon cycling in socio-ecological systems. It describes an iterative process of designing and analyzing assessment and interview data from students in upper elementary through high school. The product of our development…

An Evaluation of the Effects of Graphic Aids in Improving Decision Accuracy in a Continuous Treatment Design

ERIC Educational Resources Information Center

Van Norman, Ethan R.; Nelson, Peter M.; Shin, Jae-Eun; Christ, Theodore J.

2013-01-01

Educators, school psychologists, and other professionals must evaluate student progress and decide to continue, modify, or terminate instructional programs to ensure student success. For this purpose, progress-monitoring data are often collected, plotted graphically, and visually analyzed. The current study evaluated the impact of three common…

Logs Analysis of Adapted Pedagogical Scenarios Generated by a Simulation Serious Game Architecture

ERIC Educational Resources Information Center

Callies, Sophie; Gravel, Mathieu; Beaudry, Eric; Basque, Josianne

2017-01-01

This paper presents an architecture designed for simulation serious games, which automatically generates game-based scenarios adapted to learner's learning progression. We present three central modules of the architecture: (1) the learner model, (2) the adaptation module and (3) the logs module. The learner model estimates the progression of the…

Renewing America's Progress: A Positive Solution to School Reform.

ERIC Educational Resources Information Center

Genck, Fredric H.

This book was designed to help citizens evaluate and improve their local schools. It contends that the solution to the potential end of America's progress is through positive school reform--the public management of schools. It presents a system of participative and results-oriented management that is implemented by boards, administrators, and…

All over the Map: A Progress Report on the State Children's Health Insurance Program (CHIP).

ERIC Educational Resources Information Center

Edmunds, Margo; Teitelbaum, Martha; Gleason, Cassy

The State Children's Health Insurance Program (CHIP) was designed in 1997 to support working families by providing affordable, quality health coverage for their children in an efficient, effective, and coordinated way. This report examines the progress made in implementing CHIP nationwide. Information sources included the following: (1) federal…

Comparison of Progressive Prompt Delay with and without Instructive Feedback

ERIC Educational Resources Information Center

Reichow, Brian; Wolery, Mark

2011-01-01

We examined the effectiveness and efficiency of 2 instructional arrangements using progressive prompt delay (PPD) with 3 young children with autism and 1 child with developmental delays. Specifically, we compared PPD with instructive feedback (IF) to PPD without IF in an adapted alternating treatment design. The results suggested that (a) children…

Verification and Validation Process for Progressive Damage and Failure Analysis Methods in the NASA Advanced Composites Consortium

NASA Technical Reports Server (NTRS)

Wanthal, Steven; Schaefer, Joseph; Justusson, Brian; Hyder, Imran; Engelstad, Stephen; Rose, Cheryl

2017-01-01

The Advanced Composites Consortium is a US Government/Industry partnership supporting technologies to enable timeline and cost reduction in the development of certified composite aerospace structures. A key component of the consortium's approach is the development and validation of improved progressive damage and failure analysis methods for composite structures. These methods will enable increased use of simulations in design trade studies and detailed design development, and thereby enable more targeted physical test programs to validate designs. To accomplish this goal with confidence, a rigorous verification and validation process was developed. The process was used to evaluate analysis methods and associated implementation requirements to ensure calculation accuracy and to gage predictability for composite failure modes of interest. This paper introduces the verification and validation process developed by the consortium during the Phase I effort of the Advanced Composites Project. Specific structural failure modes of interest are first identified, and a subset of standard composite test articles are proposed to interrogate a progressive damage analysis method's ability to predict each failure mode of interest. Test articles are designed to capture the underlying composite material constitutive response as well as the interaction of failure modes representing typical failure patterns observed in aerospace structures.

Experiments on a Miniature Hypervelocity Shock Tube

NASA Astrophysics Data System (ADS)

Tasker, Douglas; Johnson, Carl; Murphy, Michael; Lieber, Mark; MIMS Team

2013-06-01

A miniature explosively-driven shock tube, based on the Voitenko compressor design, has been designed to produce shock speeds in light gases in excess of 80 km/s. Voitenko compressors over 1 meter in diameter have been reported but here experiments on miniature shock tubes with ~1-mm bore diameters are described. In this design a 12-mm diameter explosive pellet drives a metal plate into a hemispherical gas compression chamber. Downstream from the piston a mica diaphragm separates the gas from an evacuated shock tube which is confined by a massive polymethylmethacrylate (PMMA) block. The diaphragm eventually ruptures under the applied pressure loading and the compressed gases escape into the evacuated shock tube at hyper velocities. The progress of gas shocks in the tube and bow shocks in the PMMA are monitored with an ultra-high-speed imaging system, the Shock Wave Image Framing Technique (SWIFT). The resulting time-resolved images yield two-dimensional visualizations of shock geometry and progression. By measuring both the gas and bow shocks, accurate and unequivocal measurements of shock position history are obtained. The experimental results were compared with those of hydrocode modeling to optimize the design. The first experiments were suboptimum in that the velocities were ~16 km/s. Progress with these experiments will be reported.

PATHFINDER ATOMIC POWER PLANT TECHNICAL PROGRESS REPORT FOR JULY 1, 1959- SEPTEMBER 30, 1959

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1960-10-31

ABS>Fuel Element Research and Development. Dynamic and static corrosion tests on 8001 Al were completed. Annealmmmg of 1100 cladding on 5083 and M400 cladding on X2219 were tested at 500 deg C, and investigation continued on producing X8101 Al alloy cladding in tube plates by extrusion. Boiler fuel element capsule irradiation tests and subassembly tests are described Heat transfer loop studies and fuel fabrication for the critical facility are reported. Boiler fuel element mechanical design and testing progress is desc ribed. and the superheater fuel element temperature evaluating routine is discussed. Low- enrichment superheater fuel element development included design studiesmore » and stainless steel powder and UO/sub 2/ powder fabrication studies Reactor Mechanical Studies. Research is reported on vessel and structure design, fabrication, and testing, recirculation system design, steam separator tests, and control rod studies. Nuclear Analysis. Reactor physics studies are reported on nuclear constants, baffle plate analysis, comparison of core representations, delayed neutron fraction. and shielding analysis of the reactor building. Reactor and system dynamics and critical experiments were also studied. Chemistry. Progress is reported on recombiner. radioactive gas removal and storage, ion exchanger and radiochemical processing. (For preceding period see ACNP-5915.) (T.R.H.)« less

Increasing Psychotherapists’ Adoption and Implementation of the Evidence-based Practice of Progress Monitoring

PubMed Central

Persons, Jacqueline B.; Koerner, Kelly; Eidelman, Polina; Thomas, Cannon; Liu, Howard

2015-01-01

Evidence-based practices (EBPs) reach consumers slowly because practitioners are slow to adopt and implement them. We hypothesized that giving psychotherapists a tool + training intervention that was designed to help the therapist integrate the EBP of progress monitoring into his or her usual way of working would be associated with adoption and sustained implementation of the particular progress monitoring tool we trained them to use (the Depression Anxiety Stress Scales on our Online Progress Tracking tool) and would generalize to all types of progress monitoring measures. To test these hypotheses, we developed an online progress monitoring tool and a course that trained psychotherapists to use it, and we assessed progress monitoring behavior in 26 psychotherapists before, during, immediately after, and 12 months after they received the tool and training. Immediately after receiving the tool + training intervention, participants showed statistically significant increases in use of the online tool and of all types of progress monitoring measures. Twelve months later, participants showed sustained use of any type of progress monitoring measure but not the online tool. PMID:26618237

Increasing psychotherapists' adoption and implementation of the evidence-based practice of progress monitoring.

PubMed

Persons, Jacqueline B; Koerner, Kelly; Eidelman, Polina; Thomas, Cannon; Liu, Howard

2016-01-01

Evidence-based practices (EBPs) reach consumers slowly because practitioners are slow to adopt and implement them. We hypothesized that giving psychotherapists a tool + training intervention that was designed to help the therapist integrate the EBP of progress monitoring into his or her usual way of working would be associated with adoption and sustained implementation of the particular progress monitoring tool we trained them to use (the Depression Anxiety Stress Scales on our Online Progress Tracking tool) and would generalize to all types of progress monitoring measures. To test these hypotheses, we developed an online progress monitoring tool and a course that trained psychotherapists to use it, and we assessed progress monitoring behavior in 26 psychotherapists before, during, immediately after, and 12 months after they received the tool and training. Immediately after receiving the tool + training intervention, participants showed statistically significant increases in use of the online tool and of all types of progress monitoring measures. Twelve months later, participants showed sustained use of any type of progress monitoring measure but not the online tool. Copyright © 2015 Elsevier Ltd. All rights reserved.

Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia

PubMed Central

Johnson, David Y.; Dunkelberger, Diana L.; Henry, Maya; Haman, Aissatou; Greicius, Michael D.; Wong, Katherine; DeArmond, Stephen J.; Miller, Bruce L.; Gorno-Tempini, Maria Luisa; Geschwind, Michael D.

2015-01-01

Objective To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia. Design Case report. Setting Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease. Patient Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease. Results Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease. Conclusions These findings expand the differential of primary progressive aphasia to include prion disease. PMID:23400721

Age and Stress Prediction

NASA Technical Reports Server (NTRS)

2000-01-01

Genoa is a software product that predicts progressive aging and failure in a variety of materials. It is the result of a SBIR contract between the Glenn Research Center and Alpha Star Corporation. Genoa allows designers to determine if the materials they plan on applying to a structure are up to the task or if alternate materials should be considered. Genoa's two feature applications are its progressive failure simulations and its test verification. It allows for a reduction in inspection frequency, rapid design solutions, and manufacturing with low cost materials. It will benefit the aerospace, airline, and automotive industries, with future applications for other uses.

Electronic prototyping

NASA Technical Reports Server (NTRS)

Hopcroft, J.

1987-01-01

The potential benefits of automation in space are significant. The science base needed to support this automation not only will help control costs and reduce lead-time in the earth-based design and construction of space stations, but also will advance the nation's capability for computer design, simulation, testing, and debugging of sophisticated objects electronically. Progress in automation will require the ability to electronically represent, reason about, and manipulate objects. Discussed here is the development of representations, languages, editors, and model-driven simulation systems to support electronic prototyping. In particular, it identifies areas where basic research is needed before further progress can be made.

Design, fabricate, and provide engineering support for radiosotope thermoelectric generators for NASA'S CRHF and CASSINI missions

NASA Astrophysics Data System (ADS)

The technical progress achieved during the period 11 January through 31 March 1991 on Contract DE-AC03-91SF18852.000 Radioisotope Thermoelectric Generators and ancillary activities is described. The system contract consists of the following tasks: (1) Spacecraft Integration and Liaison; (2) Engineering Support; (3) Safety; (4) Qualify Unicouple Fabrication; (5) ETG Fabrication, Assembly and Test; (6) GSE; (7) RTG Shipping and Launch Support; (8) Designs, Reviews, and Mission Applications; (9) Project Management, Quality Assurance and Reliability; and (10) CAGO Acquisition (Capital Funds). The progress achieved is broken down into these tasks.

Creationism and intelligent design are incompatible with scientific progress: A response to Shanta and Vêdanta

PubMed Central

Caetano-Anollés, Gustavo

2016-01-01

ABSTRACT In a recent opinion paper, B.K. Shanta claims science leaves no room for the subjective aspect of consciousness, and in doing so, attacks both origin of life and evolutionary research. He claims Vêdanta, one of the 6 orthodox schools of Hindu philosophy, offers an explanation: “the origin of everything material and nonmaterial is sentient and absolute.” Here I discuss how the pseudoscience of these creationist views, which are aligned with Intelligent Design, are incompatible with scientific progress and should not be published in scientific journals. PMID:27066185

Terrestrial Planet Finder Interferometer: Architecture, Mission Design and Technology Development

NASA Technical Reports Server (NTRS)

Henry, Curt; Lay, Oliver; Aung, MiMi; Gunter, Steven M.; Dubovitsky, Serge; Blackwood, Gary

2004-01-01

This overview paper is a progress report about the system design and technology development of two interferometer concepts studied for the Terrestrial Planet Finder (TPF) project. The two concepts are a structurally-connected interferometer (SCI) intended to fulfill minimum TPF science goals and a formation-flying interferometer (FFI) intended to fulfill full science goals. Described are major trades, analyses, and technology experiments completed. Near term plans are also described. This paper covers progress since August 2003 and serves as an update to a paper presented at that month's SPIE conference, 'Techniques and Instrumentation for Detection of Exoplanets.

Managing a big ground-based astronomy project: the Thirty Meter Telescope (TMT) project

NASA Astrophysics Data System (ADS)

Sanders, Gary H.

2008-07-01

TMT is a big science project and its scale is greater than previous ground-based optical/infrared telescope projects. This paper will describe the ideal "linear" project and how the TMT project departs from that ideal. The paper will describe the needed adaptations to successfully manage real world complexities. The progression from science requirements to a reference design, the development of a product-oriented Work Breakdown Structure (WBS) and an organization that parallels the WBS, the implementation of system engineering, requirements definition and the progression through Conceptual Design to Preliminary Design will be summarized. The development of a detailed cost estimate structured by the WBS, and the methodology of risk analysis to estimate contingency fund requirements will be summarized. Designing the project schedule defines the construction plan and, together with the cost model, provides the basis for executing the project guided by an earned value performance measurement system.

Development of an extended-burnup Mark B design. First semi-annual progress report, July-December 1978. Report BAW-1532-1. [PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1979-10-01

The primary objective of this program is to develop and demonstrate an improved PWR fuel assembly design capable of batch average burnups of 45,000-50,000 MWd/mtU. To accomplish this, a number of technical areas must be investigated to verify acceptable extended-burnup fuel performance. This report is the first semi-annual progress report for the program, and it describes work performed during the July-December 1978 time period. Efforts during this period included the definition of a preliminary design for a high-burnup fuel rod, physics analyses of extended-burnup fuel cycles, studies of the physics characteristics of changes in fuel assembly metal-to-water ratios, and developmentmore » of a design concept for post-irradiation examination equipment to be utilized in examining high-burnup lead-test assemblies.« less

Applications of numerical optimization methods to helicopter design problems: A survey

NASA Technical Reports Server (NTRS)

Miura, H.

1984-01-01

A survey of applications of mathematical programming methods is used to improve the design of helicopters and their components. Applications of multivariable search techniques in the finite dimensional space are considered. Five categories of helicopter design problems are considered: (1) conceptual and preliminary design, (2) rotor-system design, (3) airframe structures design, (4) control system design, and (5) flight trajectory planning. Key technical progress in numerical optimization methods relevant to rotorcraft applications are summarized.

Applications of numerical optimization methods to helicopter design problems - A survey

NASA Technical Reports Server (NTRS)

Miura, H.

1985-01-01

A survey of applications of mathematical programming methods is used to improve the design of helicopters and their components. Applications of multivariable search techniques in the finite dimensional space are considered. Five categories of helicopter design problems are considered: (1) conceptual and preliminary design, (2) rotor-system design, (3) airframe structures design, (4) control system design, and (5) flight trajectory planning. Key technical progress in numerical optimization methods relevant to rotorcraft applications are summarized.

Applications of numerical optimization methods to helicopter design problems - A survey

NASA Technical Reports Server (NTRS)

Miura, H.

1984-01-01

A survey of applications of mathematical programming methods is used to improve the design of helicopters and their components. Applications of multivariable search techniques in the finite dimensional space are considered. Five categories of helicopter design problems are considered: (1) conceptual and preliminary design, (2) rotor-system design, (3) airframe structures design, (4) control system design, and (5) flight trajectory planning. Key technical progress in numerical optimization methods relevant to rotorcraft applications are summarized.

Reducing empiricism in malaria vaccine design.

PubMed

Moorthy, Vasee S; Kieny, Marie Paule

2010-03-01

Gains in the control of malaria and the promising progress of a malaria vaccine that is partly efficacious do not reduce the need for a high-efficacy vaccine in the longer term. Evidence supports the feasibility of developing a highly efficacious malaria vaccine. However, design of candidate malaria vaccines remains empirical and is necessarily based on many unproven assumptions because much of the knowledge needed to design vaccines and to predict efficacy is not available. Data to inform key questions of vaccine science might allow the design of vaccines to progress to a less empirical stage, for example through availability of assay results associated with vaccine efficacy. We discuss six strategic gaps in knowledge that contribute to empiricism in the design of vaccines. Comparative evaluation, assay and model standardisation, greater sharing of information, collaboration and coordination between groups, and rigorous evaluation of existing datasets are steps that can be taken to enable reductions in empiricism over time. 2010 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

French, T.

The Warden ASP project has progressed from the initial planning stage to construction of an injection plant. An ASP chemical system was designed based on laboratory evaluations that included interfacial tension, mobility requirements, rock-alkali interaction, fluid capabilities, and core tests. Field cores were obtained from the Permian No. 5 and No. 6 sands on the Warden lease in Sho-Vel-Tum oil field. A separate tank battery for the pilot pattern area was installed, and a field tracer test is currently being evaluated. Tracer test results to date indicate that there is no major fracturing in the No. 5 sand. There ismore » indication, however, of some channeling through high permeability sand. The field injection plant was designed, and construction is in progress. Several variations of injection plant design have been evaluated. Some plant design details, such as alkali storage, were found to be dependent on the availability of use equipment and project budget. The surfactant storage facility design was shown to be dependent on surfactant rheology.« less

Biomedically relevant circuit-design strategies in mammalian synthetic biology

PubMed Central

Bacchus, William; Aubel, Dominique; Fussenegger, Martin

2013-01-01

The development and progress in synthetic biology has been remarkable. Although still in its infancy, synthetic biology has achieved much during the past decade. Improvements in genetic circuit design have increased the potential for clinical applicability of synthetic biology research. What began as simple transcriptional gene switches has rapidly developed into a variety of complex regulatory circuits based on the transcriptional, translational and post-translational regulation. Instead of compounds with potential pharmacologic side effects, the inducer molecules now used are metabolites of the human body and even members of native cell signaling pathways. In this review, we address recent progress in mammalian synthetic biology circuit design and focus on how novel designs push synthetic biology toward clinical implementation. Groundbreaking research on the implementation of optogenetics and intercellular communications is addressed, as particularly optogenetics provides unprecedented opportunities for clinical application. Along with an increase in synthetic network complexity, multicellular systems are now being used to provide a platform for next-generation circuit design. PMID:24061539

Status of ITER Cryodistribution and Cryoline project

NASA Astrophysics Data System (ADS)

Sarkar, B.; Vaghela, H.; Shah, N.; Bhattacharya, R.; Choukekar, K.; Patel, P.; Kapoor, H.; Srinivasa, M.; Chang, H. S.; Badgujar, S.; Monneret, E.

2017-02-01

The system of ITER Cryodistribution (CD) and Cryolines (CLs) is an integral interface between the Cryoplant systems and the superconducting (SC) magnets as well as Cryopumps (CPs). The project has progressed from the conceptual stage to the industrial stage. The subsystems are at various stages of design as defined by the project, namely, preliminary design, final design and formal reviews. Significant progresses have been made in the prototypes studies and design validations, such as the CL and cold circulators. While one of the prototype CL is already tested, the other one is in manufacturing phase. Performance test of two cold circulators have been completed. Design requirements are unique due the complexity arising from load specifications, layout constraints, regulatory compliance, operating conditions as well as several hundred interfaces. The present status of the project in terms of technical achievements, implications of the changes and the technical management as well as the risk assessment and its mitigation including path forward towards realization is described.

High-Speed Research: 1994 Sonic Boom Workshop. Configuration, Design, Analysis and Testing

NASA Technical Reports Server (NTRS)

McCurdy, David A. (Editor)

1999-01-01

The third High-Speed Research Sonic Boom Workshop was held at NASA Langley Research Center on June 1-3, 1994. The purpose of this workshop was to provide a forum for Government, industry, and university participants to present and discuss progress in their research. The workshop was organized into sessions dealing with atmospheric propagation; acceptability studies; and configuration design, and testing. Attendance at the workshop was by invitation only. The workshop proceedings include papers on design, analysis, and testing of low-boom high-speed civil transport configurations and experimental techniques for measuring sonic booms. Significant progress is noted in these areas in the time since the previous workshop a year earlier. The papers include preliminary results of sonic boom wind tunnel tests conducted during 1993 and 1994 on several low-boom designs. Results of a mission performance analysis of all low-boom designs are also included. Two experimental methods for measuring near-field signatures of airplanes in flight are reported.

SUSTAINABLE ALLOY DESIGN: SEARCHING FOR RARE EARTH ELEMENT ALTERNATIVES THROUGH CRYSTAL ENGINEERING

DTIC Science & Technology

2016-02-26

Property Maps to Guide Materials Design via Statistical Learning Summer Research Group Meeting – Materials by Design Los Alamos National Laboratory, July...Informatics, Rational design , Quantitative correlative spectroscopy and imaging, DFT, In situ high pressure mechanical property measurements, Superalloy...final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED. Indicate the

Progressive Visual Analytics: User-Driven Visual Exploration of In-Progress Analytics.

PubMed

Stolper, Charles D; Perer, Adam; Gotz, David

2014-12-01

As datasets grow and analytic algorithms become more complex, the typical workflow of analysts launching an analytic, waiting for it to complete, inspecting the results, and then re-Iaunching the computation with adjusted parameters is not realistic for many real-world tasks. This paper presents an alternative workflow, progressive visual analytics, which enables an analyst to inspect partial results of an algorithm as they become available and interact with the algorithm to prioritize subspaces of interest. Progressive visual analytics depends on adapting analytical algorithms to produce meaningful partial results and enable analyst intervention without sacrificing computational speed. The paradigm also depends on adapting information visualization techniques to incorporate the constantly refining results without overwhelming analysts and provide interactions to support an analyst directing the analytic. The contributions of this paper include: a description of the progressive visual analytics paradigm; design goals for both the algorithms and visualizations in progressive visual analytics systems; an example progressive visual analytics system (Progressive Insights) for analyzing common patterns in a collection of event sequences; and an evaluation of Progressive Insights and the progressive visual analytics paradigm by clinical researchers analyzing electronic medical records.

Flat-plate solar array progress and plans

NASA Technical Reports Server (NTRS)

Callaghan, W. T.; Henry, P. K.

1984-01-01

The Flat-Plate Solar Array Project (FSA), sponsored by the U.S. Department of Energy (DOE) and managed by the Jet Propulsion Laboratory (JPL), has achieved progress in a broad range of technical activities since that reported at the Fourth European Communities Conference. A particularly important analysis has been completed recently which confirms the adoption into practice by the U.S. Photovoltaic (PV Industry, of all the low-cost module technology elements proposed at the 16th Project Integration Meeting for a $2.80/Wp (1980 U.S. Dollars) design approach in the fall of 1980. This work presents along with a projection, using the same techniques, for what is believed to be a very credible ribbon-based module design for less that $0.55/Wp (1980 U.S. Dollars). Other areas to be reported upon include low-cost Si feedstock refinement; ribbon growth; process sequence development for cells; environmental isolation; engineering science investigations; and module testing progress.

Progress of MICE RFCC Module

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, D.; Bowring, D.; DeMello, A.

2012-05-20

Recent progress on the design and fabrication of the RFCC (RF and superconducting Coupling Coil) module for the international MICE (Muon Ionization Cooling Experiment) are reported. The MICE ionization cooling channel has two RFCC modules, each having four 201- MHz normal conducting RF cavities surrounded by one superconducting coupling coil (solenoid) magnet. The magnet is designed to be cooled by three cryocoolers. Fabrication of the RF cavities is complete; preparation for the cavity electro-polishing, low power RF measurements, and tuning are in progress at Lawrence Berkeley National Laboratory (LBNL). Fabrication of the cold mass of the first coupling coil magnetmore » has been completed in China and the cold mass arrived at LBNL in late 2011. Preparations for testing the cold mass are currently under way at Fermilab. Plans for the RFCC module assembly and integration are being developed and are described.« less

Design rules for quantum imaging devices: experimental progress using CMOS single-photon detectors

NASA Astrophysics Data System (ADS)

Charbon, Edoardo; Gunther, Neil J.; Boiko, Dmitri L.; Beretta, Giordano B.

2006-08-01

We continue our previous program1 where we introduced a set of quantum-based design rules directed at quantum engineers who design single-photon quantum communications and quantum imaging devices. Here, we report on experimental progress using SPAD (single photon avalanche diode) arrays of our design and fabricated in CMOS (complementary metal oxide semiconductor) technology. Emerging high-resolution imaging techniques based on SPAD arrays have proven useful in a variety of disciplines including bio-fluorescence microscopy and 3D vision systems. They have also been particularly successful for intra-chip optical communications implemented entirely in CMOS technology. More importantly for our purposes, a very low dark count allows SPADs to detect rare photon events with a high dynamic range and high signal-to-noise ratio. Our CMOS SPADs support multi-channel detection of photon arrivals with picosecond accuracy, several million times per second, due to a very short detection cycle. The tiny chip area means they are suitable for highly miniaturized quantum imaging devices and that is how we employ them in this paper. Our quantum path integral analysis of the Young-Afshar-Wheeler interferometer showed that Bohr's complementarity principle was not violated due the previously overlooked effect of photon bifurcation within the lens--a phenomenon consistent with our quantum design rules--which accounts for the loss of which-path information in the presence of interference. In this paper, we report on our progress toward the construction of quantitative design rules as well as some proposed tests for quantum imaging devices using entangled photon sources with our SPAD imager.

Analyzing Students' Learning Progressions Throughout a Teaching Sequence on Acoustic Properties of Materials with a Model-Based Inquiry Approach

NASA Astrophysics Data System (ADS)

Hernández, María Isabel; Couso, Digna; Pintó, Roser

2015-04-01

The study we have carried out aims to characterize 15- to 16-year-old students' learning progressions throughout the implementation of a teaching-learning sequence on the acoustic properties of materials. Our purpose is to better understand students' modeling processes about this topic and to identify how the instructional design and actual enactment influences students' learning progressions. This article presents the design principles which elicit the structure and types of modeling and inquiry activities designed to promote students' development of three conceptual models. Some of these activities are enhanced by the use of ICT such as sound level meters connected to data capture systems, which facilitate the measurement of the intensity level of sound emitted by a sound source and transmitted through different materials. Framing this study within the design-based research paradigm, it consists of the experimentation of the designed teaching sequence with two groups of students ( n = 29) in their science classes. The analysis of students' written productions together with classroom observations of the implementation of the teaching sequence allowed characterizing students' development of the conceptual models. Moreover, we could evidence the influence of different modeling and inquiry activities on students' development of the conceptual models, identifying those that have a major impact on students' modeling processes. Having evidenced different levels of development of each conceptual model, our results have been interpreted in terms of the attributes of each conceptual model, the distance between students' preliminary mental models and the intended conceptual models, and the instructional design and enactment.

A General Set of Procedures for Constructivist Instructional Design: The New R2D2 Model.

ERIC Educational Resources Information Center

Willis, Jerry; Wright, Kristen Egeland

2000-01-01

Describes the R2D2 (Reflective, Recursive Design and Development) model of constructivist instructional design. Highlights include participatory teams; progressive problem solution; phronesis, or contextual understanding; dissemination, including summative evaluation; and a new paradigm that shifts from the industrial age to the information age.…

Designing E-Learning Environments for Flexible Activity and Instruction

ERIC Educational Resources Information Center

Wilson, Brent G.

2004-01-01

The contributions to this issue share a focus on design of e-learning environments. Instructional designers stand at very early stages of knowledge in this area, but with great potential for growth and progress. This commentary offers an activity-based perspective on e-learning environments, resulting in a flexible stance toward instructional…

Tying Theory To Practice: Cognitive Aspects of Computer Interaction in the Design Process.

ERIC Educational Resources Information Center

Mikovec, Amy E.; Dake, Dennis M.

The new medium of computer-aided design requires changes to the creative problem-solving methodologies typically employed in the development of new visual designs. Most theoretical models of creative problem-solving suggest a linear progression from preparation and incubation to some type of evaluative study of the "inspiration." These…

Analysis for the Progressive Failure Response of Textile Composite Fuselage Frames

NASA Technical Reports Server (NTRS)

Johnson, Eric R.; Boitnott, Richard L. (Technical Monitor)

2002-01-01

A part of aviation accident mitigation is a crash worthy airframe structure, and an important measure of merit for a crash worthy structure is the amount of kinetic energy that can be absorbed in the crush of the structure. Prediction of the energy absorbed from finite element analyses requires modeling the progressive failure sequence. Progressive failure modes may include material degradation, fracture and crack growth, and buckling and collapse. The design of crash worthy airframe components will benefit from progressive failure analyses that have been validated by tests. The subject of this research is the development of a progressive failure analysis for textile composite. circumferential fuselage frames subjected to a quasi-static, crash-type load. The test data for these frames are reported, and these data, along with stub column test data, are to be used to develop and to validate methods for the progressive failure response.

34 CFR Appendix A to Part 104 - Analysis of Final Regulation

Code of Federal Regulations, 2012 CFR

2012-07-01

... facilities, be designed and constructed in a manner so as to make the facility accessible to and usable by... will not be required to alter the design of a facility that has progressed beyond groundbreaking prior...

34 CFR Appendix A to Part 104 - Analysis of Final Regulation

Code of Federal Regulations, 2013 CFR

2013-07-01

... facilities, be designed and constructed in a manner so as to make the facility accessible to and usable by... will not be required to alter the design of a facility that has progressed beyond groundbreaking prior...

34 CFR Appendix A to Part 104 - Analysis of Final Regulation

Code of Federal Regulations, 2014 CFR

2014-07-01

... facilities, be designed and constructed in a manner so as to make the facility accessible to and usable by... will not be required to alter the design of a facility that has progressed beyond groundbreaking prior...

34 CFR Appendix A to Part 104 - Analysis of Final Regulation

Code of Federal Regulations, 2011 CFR

2011-07-01

... facilities, be designed and constructed in a manner so as to make the facility accessible to and usable by... will not be required to alter the design of a facility that has progressed beyond groundbreaking prior...

An assessment of laser velocimetry in hypersonic flow

NASA Technical Reports Server (NTRS)

1992-01-01

Although extensive progress has been made in computational fluid mechanics, reliable flight vehicle designs and modifications still cannot be made without recourse to extensive wind tunnel testing. Future progress in the computation of hypersonic flow fields is restricted by the need for a reliable mean flow and turbulence modeling data base which could be used to aid in the development of improved empirical models for use in numerical codes. Currently, there are few compressible flow measurements which could be used for this purpose. In this report, the results of experiments designed to assess the potential for laser velocimeter measurements of mean flow and turbulent fluctuations in hypersonic flow fields are presented. Details of a new laser velocimeter system which was designed and built for this test program are described.

Designing the National Assessment of Educational Progress to Serve a Wider Community of Users: A Position Paper.

ERIC Educational Resources Information Center

Bock, R. Darrell

Efforts have been made to increase the dissemination and use of data generated by the National Assessment of Educational Progress (NAEP). Potential users include those concerned with curriculum and methods evaluation, public policymakers, and researchers. NAEP can provide data for curriculum evaluation, including item analysis data which assist in…

Reporting Florida's Annual Measurable Objectives (AMOs) in Compliance with ESEA Flexibility Requirements: Guide to Calculations for 2013-14

ERIC Educational Resources Information Center

Florida Department of Education, 2014

2014-01-01

This Annual Measurable Objective (AMO) is designed to keep Florida moving forward toward national and international competitiveness. Florida will compare its National Assessment of Educational Progress (NAEP) scores to those of the top five states and its Trends in International Mathematics and Science Study (TIMSS), Progress in International…

The Community College and International Education: A Report of Progress. Volume II.

ERIC Educational Resources Information Center

Fersh, Seymour, Ed.; Greene, William, Ed.

Designed to highlight the progress made by community colleges in the United States in the area of international education, this report presents a collection of materials representing various state and institutional initiatives and efforts. Part I contains articles by Hugh Adams and William Greene, and Maxwell King and Seymour Fersh that provide a…

40 CFR Table 5 to Subpart Fff of... - Generic Compliance Schedules and Increments of Progress

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Generic Compliance Schedules and Increments of Progress 5 Table 5 to Subpart FFF of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan...

40 CFR Table 5 to Subpart Fff of... - Generic Compliance Schedules and Increments of Progress

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Generic Compliance Schedules and Increments of Progress 5 Table 5 to Subpart FFF of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan...

Economics Framework for the 2006 National Assessment of Educational Progress

ERIC Educational Resources Information Center

Buckles, Stephen; Melican, Claire

2006-01-01

This document provides a guide for the development of the 2006 National Assessment of Educational Progress (NAEP) Economics Assessment. The framework is designed to assess the outcomes of student education in and understanding of economics in grade 12 as part of NAEP. Economic literacy is defined as the ability to identify, analyze, and evaluate…

Using Stephen Crane's "Maggie" To Teach the Progressive Era.

ERIC Educational Resources Information Center

Gerwin, David; Manolios, Vassilios; Popodopoulos, Lia

1999-01-01

Outlines a lesson plan designed for an eleventh-grade U.S. history class in which the students learn about the Progressive Era by reading Stephen Crane's "Maggie: A Girl of the Streets." Explains that students analyze point of view, role play a talk show, write an essay, and complete a long-term research project. (CMK)

Student Perceptions of the Progress Test in Two Settings and the Implications for Test Deployment

ERIC Educational Resources Information Center

Wade, Louise; Harrison, Chris; Hollands, James; Mattick, Karen; Ricketts, Chris; Wass, Val

2012-01-01

Background: The Progress Test (PT) was developed to assess student learning within integrated curricula. Whilst it is effective in promoting and rewarding deep approaches to learning in some settings, we hypothesised that implementation of the curriculum (design and assessment) may impact on students' preparation for the PT and their learning.…

Developmental Progression of Looking and Reaching Performance on the A-Not-B Task

ERIC Educational Resources Information Center

Cuevas, Kimberly; Bell, Martha Ann

2010-01-01

From a neuropsychological perspective, the cognitive skills of working memory, inhibition, and attention and the maturation of the frontal lobe are requisites for successful A-not-B performance on both the looking and reaching versions of the task. This study used a longitudinal design to examine the developmental progression of infants'…

The Achievement Progress of English Learner Students in Nevada. REL 2016-154

ERIC Educational Resources Information Center

Haas, Eric; Huang, Min; Tran, Loan; Yu, Airong

2016-01-01

The purpose of this study was to examine the cumulative progress of English learner students in Nevada in English language proficiency (ELP) and in academic content knowledge in both reading and mathematics. This study identified students in grades kindergarten, 3, and 6 who were designated as English learner students in 2006/07 and examined their…

40 CFR Table 5 to Subpart Fff of... - Generic Compliance Schedules and Increments of Progress

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 9 2012-07-01 2012-07-01 false Generic Compliance Schedules and Increments of Progress 5 Table 5 to Subpart FFF of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan...

40 CFR Table 5 to Subpart Fff of... - Generic Compliance Schedules and Increments of Progress

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 9 2014-07-01 2014-07-01 false Generic Compliance Schedules and Increments of Progress 5 Table 5 to Subpart FFF of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan...

40 CFR Table 5 to Subpart Fff of... - Generic Compliance Schedules and Increments of Progress

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 9 2013-07-01 2013-07-01 false Generic Compliance Schedules and Increments of Progress 5 Table 5 to Subpart FFF of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan...

Teacher Progress Monitoring of Instructional and Behavioral Management Practices: An Evidence-Based Approach to Improving Classroom Practices

ERIC Educational Resources Information Center

Reddy, Linda A.; Dudek, Christopher M.

2014-01-01

In the era of teacher evaluation and effectiveness, assessment tools that identify and monitor educators' instruction and behavioral management practices are in high demand. The Classroom Strategies Scale (CSS) Observer Form is a multidimensional teacher progress monitoring tool designed to assess teachers' usage of instructional and behavioral…

Science Framework for the 2009 National Assessment of Educational Progress

ERIC Educational Resources Information Center

National Assessment Governing Board, 2008

2008-01-01

This document sets forth recommendations for the design of a new science assessment. The assessment resulting from this framework will start a new NAEP science trend (i.e., measure of student progress in science) beginning in 2009. This framework represents a unique opportunity to build on previous NAEP science work as well as key developments in…

The Effects of Audiotaped Progressive Muscle Relaxation Training on the Reading Performance of Emotionally Disturbed Adolescents.

ERIC Educational Resources Information Center

Margolis, Howard; Pica, Louis, Jr.

A study examined the degree to which audiotaped progressive muscle relaxation training influenced the oral and silent reading performance of eight adolescents who were legally classified as emotionally disturbed. A single-case ABAB withdrawal design was used to examine the effects of relaxation training on oral reading. In addition, a…

Annual Technical Progress Report for Emergency School Assistance Program, Title 45, 1970-71.

ERIC Educational Resources Information Center

Lindsey, Randall B.

This paper presents a technical progress report of two programs conducted with funds provided under the Emergency School Assistance Program. One, the Mobile Learning Unit, said to have been designed to measure changes in fourth and fifth grade students' self-concept in a reorganized desegregated school environment, focuses on whether a positive…

Progressive Achievement Tests in Reading: Comprehension & Vocabulary. Teacher's Handbook. Second Edition.

ERIC Educational Resources Information Center

Australian Council for Educational Research, Hawthorn.

The teacher handbook for Progressive Achievement Tests (PATs) in Reading presents an overall description of these survey tests in reading comprehension and vocabulary knowledge for school years 3 to 9. There are two alternative forms of each test: (1) the Reading Comprehension tests are designed to measure two major aspects of reading skills…

A Learning Progression for Scientific Argumentation: Understanding Student Work and Designing Supportive Instructional Contexts

ERIC Educational Resources Information Center

Berland, Leema K.; McNeill, Katherine L.

2010-01-01

Argumentation is a central goal of science education because it engages students in a complex scientific practice in which they construct and justify knowledge claims. Although there is a growing body of research around argumentation, there has been little focus on developing a learning progression for this practice. We describe a learning…

Third Progress and Information Report of the Vocational-Technical Education Consortium of States.

ERIC Educational Resources Information Center

Lee, Connie W.; And Others

This description of major activities and accomplishments of the Vocational-Technical Education Consortium of the States (V-TECS) since the second progress report of May, 1975, is designed to provide the reader with a basic understanding of the processes and procedures used by the consortium in achieving its major goal: The production of catalogs…

Patient Activities Planning and Progress Noting a Humanistic Integrated-Team Approach.

ERIC Educational Resources Information Center

Muilenburg, Ted

This document outlines a system for planning recreation therapy, documenting progress, and relating the entire process to a team approach which includes patient assessment and involvement. The recreation program is seen as therapeutic, closely related to the total medical treatment program. The model is designed so that it can be adapted to almost…

IODC 1998 Lens Design Problem Revisited: A Strategy for Simplifying Glass Choices in an Apochromatic Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seppala, L G

2000-09-15

A glass-choice strategy, based on separately designing an achromatic lens before progressing to an apochromatic lens, simplified my approach to solving the International Optical Design Conference (IODC) 1998 lens design problem. The glasses that are needed to make the lens apochromatic are combined into triplet correctors with two ''buried'' surfaces. By applying this strategy, I reached successful solutions that used only six glasses--three glasses for the achromatic design and three additional glasses for the apochromatic design.

State budget transfers to Health Insurance to expand coverage to people outside formal sector work in Latin America.

PubMed

Mathauer, Inke; Behrendt, Thorsten

2017-02-16

Contributory social health insurance for formal sector employees only has proven challenging for moving towards universal health coverage (UHC). This is because the informally employed and the poor usually remain excluded. One way to expand UHC is to fully or partially subsidize health insurance contributions for excluded population groups through government budget transfers. This paper analyses the institutional design features of such government subsidization arrangements in Latin America and assesses their performance with respect to UHC progress. The aim is to identify UHC conducive institutional design features of such arrangements. A literature search provided the information to analyse institutional design features, with a focus on the following aspects: eligibility/enrolment rules, financing and pooling arrangements, and purchasing and benefit package design. Based on secondary data analysis, UHC progress is assessed in terms of improved population coverage, financial protection and access to needed health care services. Such government subsidization arrangements currently exist in eight countries of Latin America (Bolivia, Chile, Colombia, Costa Rica, Dominican Republic, Mexico, Peru, Uruguay). Institutional design features and UHC related performance vary significantly. Notably, countries with a universalist approach or indirect targeting have higher population coverage rates. Separate pools for the subsidized maintain inequitable access. The relatively large scopes of the benefit packages had a positive impact on financial protection and access to care. In the long term, merging different schemes into one integrated health financing system without opt-out options for the better-off is desirable, while equally expanding eligibility to cover those so far excluded. In the short and medium term, the harmonization of benefit packages could be a priority. UHC progress also depends on substantial supply side investments to ensure the availability of quality services, particularly in rural areas. Future research should generate more evidence on the implementation process and impact of subsidization arrangements on UHC progress.

Design evolution of a low shock release nut

NASA Technical Reports Server (NTRS)

Otth, D. H.; Gordon, W.

1976-01-01

Design improvements and detailed functional analyses are reviewed to trace the development of a pyroactuated release device with segmented thread design from its intermediate design into one that reduces the levels of shock spectra generated during its operation by 50%. Comparisons of shock output and internal load distribution are presented, along with descriptions of mechanical operation for both designs. Results also show the potential areas where design development activity can gain further progress in lowering actuation shock levels.

Model based design introduction: modeling game controllers to microprocessor architectures

NASA Astrophysics Data System (ADS)

Jungwirth, Patrick; Badawy, Abdel-Hameed

2017-04-01

We present an introduction to model based design. Model based design is a visual representation, generally a block diagram, to model and incrementally develop a complex system. Model based design is a commonly used design methodology for digital signal processing, control systems, and embedded systems. Model based design's philosophy is: to solve a problem - a step at a time. The approach can be compared to a series of steps to converge to a solution. A block diagram simulation tool allows a design to be simulated with real world measurement data. For example, if an analog control system is being upgraded to a digital control system, the analog sensor input signals can be recorded. The digital control algorithm can be simulated with the real world sensor data. The output from the simulated digital control system can then be compared to the old analog based control system. Model based design can compared to Agile software develop. The Agile software development goal is to develop working software in incremental steps. Progress is measured in completed and tested code units. Progress is measured in model based design by completed and tested blocks. We present a concept for a video game controller and then use model based design to iterate the design towards a working system. We will also describe a model based design effort to develop an OS Friendly Microprocessor Architecture based on the RISC-V.

An accurate binding interaction model in de novo computational protein design of interactions: if you build it, they will bind.

PubMed

London, Nir; Ambroggio, Xavier

2014-02-01

Computational protein design efforts aim to create novel proteins and functions in an automated manner and, in the process, these efforts shed light on the factors shaping natural proteins. The focus of these efforts has progressed from the interior of proteins to their surface and the design of functions, such as binding or catalysis. Here we examine progress in the development of robust methods for the computational design of non-natural interactions between proteins and molecular targets such as other proteins or small molecules. This problem is referred to as the de novo computational design of interactions. Recent successful efforts in de novo enzyme design and the de novo design of protein-protein interactions open a path towards solving this problem. We examine the common themes in these efforts, and review recent studies aimed at understanding the nature of successes and failures in the de novo computational design of interactions. While several approaches culminated in success, the use of a well-defined structural model for a specific binding interaction in particular has emerged as a key strategy for a successful design, and is therefore reviewed with special consideration. Copyright © 2013 Elsevier Inc. All rights reserved.

Optical Metamaterials: Design, Characterization and Applications

ERIC Educational Resources Information Center

Chaturvedi, Pratik

2009-01-01

Artificially engineered metamaterials have emerged with properties and functionalities previously unattainable in natural materials. The scientific breakthroughs made in this new class of electromagnetic materials are closely linked with progress in developing physics-driven design, novel fabrication and characterization methods. The intricate…

Progress-like logistical supply vehicle and the Mars Manned Mission architecture

NASA Astrophysics Data System (ADS)

Keith, E. L.

1993-06-01

The paper examines the economics of the Russian Progress spacecraft (which has been used to supply Russian space stations with propellant and fresh supplies since 1978), as applied to the American Manned Mars Mission architecture. The results of the examination show that an economic American Progress-like vehicle could be designed significantly different from the Russian spacecraft. The use of a Progress-like vehicle could permit Manned Mars missions without the need for larger heavy-lift vehicles that do not now exist in the American inventory. A MIR-like Manned Mars mission architecture would also enable elimination of most of the extravehicular activity required to assemble a Mars-bound craft.

Recent Progress in the Design of Advanced Cathode Materials and Battery Models for High-Performance Lithium-X (X = O2 , S, Se, Te, I2 , Br2 ) Batteries.

PubMed

Xu, Jiantie; Ma, Jianmin; Fan, Qinghua; Guo, Shaojun; Dou, Shixue

2017-07-01

Recent advances and achievements in emerging Li-X (X = O 2 , S, Se, Te, I 2 , Br 2 ) batteries with promising cathode materials open up new opportunities for the development of high-performance lithium-ion battery alternatives. In this review, we focus on an overview of recent important progress in the design of advanced cathode materials and battery models for developing high-performance Li-X (X = O 2 , S, Se, Te, I 2 , Br 2 ) batteries. We start with a brief introduction to explain why Li-X batteries are important for future renewable energy devices. Then, we summarize the existing drawbacks, major progress and emerging challenges in the development of cathode materials for Li-O 2 (S) batteries. In terms of the emerging Li-X (Se, Te, I 2 , Br 2 ) batteries, we systematically summarize their advantages/disadvantages and recent progress. Specifically, we review the electrochemical performance of Li-Se (Te) batteries using carbonate-/ether-based electrolytes, made with different electrode fabrication techniques, and of Li-I 2 (Br 2 ) batteries with various cell designs (e.g., dual electrolyte, all-organic electrolyte, with/without cathode-flow mode, and fuel cell/solar cell integration). Finally, the perspective on and challenges for the development of cathode materials for the promising Li-X (X = O 2 , S, Se, Te, I 2 , Br 2 ) batteries is presented. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

DEVELOPMENT OF IMPROVED FABRICATION METHODS, PROCESS AND TECHNIQUES FOR PRODUCING TYPICAL AIRCRAFT SHAPES FROM BERYLLIUM. Interim Technical Documentary Progress Report for the Period ending October 31, 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jenkins, R.G.; Siergiej, J.M.

1962-12-28

In a program to develop a complete manufacturing process for ihe production of beryllium channels, techniques are being sought for drawing to obtain a flnal product meeting specifications more rigorous than are obtainable by direct extrusion. Progress in designing and procuring the special tooling required to draw complex shapes at elevated temperature is described, and the flrst set of draw dies is evaluated with respect to design and quality. Three experimental draw attempts have been made on U-channels, in addition to draw tests on flats. (auth)

Recent progress in n-channel organic thin-film transistors.

PubMed

Wen, Yugeng; Liu, Yunqi

2010-03-26

Particular attention has been focused on n-channel organic thin-film transistors (OTFTs) during the last few years, and the potentially cost-effective circuitry-based applications in flexible electronics, such as flexible radiofrequency identity tags, smart labels, and simple displays, will benefit from this fast development. This article reviews recent progress in performance and molecular design of n-channel semiconductors in the past five years, and limitations and practicable solutions for n-channel OTFTs are dealt with from the viewpoint of OTFT constitution and geometry, molecular design, and thin-film growth conditions. Strategy methodology is especially highlighted with an aim to investigate basic issues in this field.

Recent Progresses in Nanobiosensing for Food Safety Analysis

PubMed Central

Yang, Tao; Huang, Huifen; Zhu, Fang; Lin, Qinlu; Zhang, Lin; Liu, Junwen

2016-01-01

With increasing adulteration, food safety analysis has become an important research field. Nanomaterials-based biosensing holds great potential in designing highly sensitive and selective detection strategies necessary for food safety analysis. This review summarizes various function types of nanomaterials, the methods of functionalization of nanomaterials, and recent (2014–present) progress in the design and development of nanobiosensing for the detection of food contaminants including pathogens, toxins, pesticides, antibiotics, metal contaminants, and other analytes, which are sub-classified according to various recognition methods of each analyte. The existing shortcomings and future perspectives of the rapidly growing field of nanobiosensing addressing food safety issues are also discussed briefly. PMID:27447636

High-power klystrons

NASA Astrophysics Data System (ADS)

Siambis, John G.; True, Richard B.; Symons, R. S.

1994-05-01

Novel emerging applications in advanced linear collider accelerators, ionospheric and atmospheric sensing and modification and a wide spectrum of industrial processing applications, have resulted in microwave tube requirements that call for further development of high power klystrons in the range from S-band to X-band. In the present paper we review recent progress in high power klystron development and discuss some of the issues and scaling laws for successful design. We also discuss recent progress in electron guns with potential grading electrodes for high voltage with short and long pulse operation via computer simulations obtained from the code DEMEOS, as well as preliminary experimental results. We present designs for high power beam collectors.

Recent Progresses in Nanobiosensing for Food Safety Analysis.

PubMed

Yang, Tao; Huang, Huifen; Zhu, Fang; Lin, Qinlu; Zhang, Lin; Liu, Junwen

2016-07-19

With increasing adulteration, food safety analysis has become an important research field. Nanomaterials-based biosensing holds great potential in designing highly sensitive and selective detection strategies necessary for food safety analysis. This review summarizes various function types of nanomaterials, the methods of functionalization of nanomaterials, and recent (2014-present) progress in the design and development of nanobiosensing for the detection of food contaminants including pathogens, toxins, pesticides, antibiotics, metal contaminants, and other analytes, which are sub-classified according to various recognition methods of each analyte. The existing shortcomings and future perspectives of the rapidly growing field of nanobiosensing addressing food safety issues are also discussed briefly.

Constitutive behavior and progressive mechanical failure of electrodes in lithium-ion batteries

NASA Astrophysics Data System (ADS)

Zhang, Chao; Xu, Jun; Cao, Lei; Wu, Zenan; Santhanagopalan, Shriram

2017-07-01

The electrodes of lithium-ion batteries (LIB) are known to be brittle and to fail earlier than the separators during an external crush event. Thus, the understanding of mechanical failure mechanism for LIB electrodes (anode and cathode) is critical for the safety design of LIB cells. In this paper, we present experimental and numerical studies on the constitutive behavior and progression of failure in LIB electrodes. Mechanical tests were designed and conducted to evaluate the constitutive properties of porous electrodes. Constitutive models were developed to describe the stress-strain response of electrodes under uniaxial tensile and compressive loads. The failure criterion and a damage model were introduced to model their unique tensile and compressive failure behavior. The failure mechanism of LIB electrodes was studied using the blunt rod test on dry electrodes, and numerical models were built to simulate progressive failure. The different failure processes were examined and analyzed in detail numerically, and correlated with experimentally observed failure phenomena. The test results and models improve our understanding of failure behavior in LIB electrodes, and provide constructive insights on future development of physics-based safety design tools for battery structures under mechanical abuse.

Constitutive behavior and progressive mechanical failure of electrodes in lithium-ion batteries

DOE PAGES

Zhang, Chao; Xu, Jun; Cao, Lei; ...

2017-05-05

The electrodes of lithium-ion batteries (LIB) are known to be brittle and to fail earlier than the separators during an external crush event. Thus, the understanding of mechanical failure mechanism for LIB electrodes (anode and cathode) is critical for the safety design of LIB cells. In this paper, we present experimental and numerical studies on the constitutive behavior and progression of failure in LIB electrodes. Mechanical tests were designed and conducted to evaluate the constitutive properties of porous electrodes. Constitutive models were developed to describe the stress-strain response of electrodes under uniaxial tensile and compressive loads. The failure criterion andmore » a damage model were introduced to model their unique tensile and compressive failure behavior. The failure mechanism of LIB electrodes was studied using the blunt rod test on dry electrodes, and numerical models were built to simulate progressive failure. The different failure processes were examined and analyzed in detail numerically, and correlated with experimentally observed failure phenomena. Finally, the test results and models improve our understanding of failure behavior in LIB electrodes, and provide constructive insights on future development of physics-based safety design tools for battery structures under mechanical abuse.« less

Progressive Damage Analysis of Bonded Composite Joints

NASA Technical Reports Server (NTRS)

Leone, Frank A., Jr.; Girolamo, Donato; Davila, Carlos G.

2012-01-01

The present work is related to the development and application of progressive damage modeling techniques to bonded joint technology. The joint designs studied in this work include a conventional composite splice joint and a NASA-patented durable redundant joint. Both designs involve honeycomb sandwich structures with carbon/epoxy facesheets joined using adhesively bonded doublers.Progressive damage modeling allows for the prediction of the initiation and evolution of damage within a structure. For structures that include multiple material systems, such as the joint designs under consideration, the number of potential failure mechanisms that must be accounted for drastically increases the complexity of the analyses. Potential failure mechanisms include fiber fracture, intraply matrix cracking, delamination, core crushing, adhesive failure, and their interactions. The bonded joints were modeled using highly parametric, explicitly solved finite element models, with damage modeling implemented via custom user-written subroutines. Each ply was discretely meshed using three-dimensional solid elements. Layers of cohesive elements were included between each ply to account for the possibility of delaminations and were used to model the adhesive layers forming the joint. Good correlation with experimental results was achieved both in terms of load-displacement history and the predicted failure mechanism(s).

Progress on the Fabric for Frontier Experiments Project at Fermilab

NASA Astrophysics Data System (ADS)

Box, Dennis; Boyd, Joseph; Dykstra, Dave; Garzoglio, Gabriele; Herner, Kenneth; Kirby, Michael; Kreymer, Arthur; Levshina, Tanya; Mhashilkar, Parag; Sharma, Neha

2015-12-01

The FabrIc for Frontier Experiments (FIFE) project is an ambitious, major-impact initiative within the Fermilab Scientific Computing Division designed to lead the computing model for Fermilab experiments. FIFE is a collaborative effort between experimenters and computing professionals to design and develop integrated computing models for experiments of varying needs and infrastructure. The major focus of the FIFE project is the development, deployment, and integration of Open Science Grid solutions for high throughput computing, data management, database access and collaboration within experiment. To accomplish this goal, FIFE has developed workflows that utilize Open Science Grid sites along with dedicated and commercial cloud resources. The FIFE project has made significant progress integrating into experiment computing operations several services including new job submission services, software and reference data distribution through CVMFS repositories, flexible data transfer client, and access to opportunistic resources on the Open Science Grid. The progress with current experiments and plans for expansion with additional projects will be discussed. FIFE has taken a leading role in the definition of the computing model for Fermilab experiments, aided in the design of computing for experiments beyond Fermilab, and will continue to define the future direction of high throughput computing for future physics experiments worldwide.

Myopia progression control lens reverses induced myopia in chicks.

PubMed

Irving, Elizabeth L; Yakobchuk-Stanger, Cristina

2017-09-01

To determine whether lens induced myopia in chicks can be reversed or reduced by wearing myopia progression control lenses of the same nominal (central) power but different peripheral designs. Newly hatched chicks wore -10D Conventional lenses unilaterally for 7 days. The myopic chicks were then randomly divided into three groups: one fitted with Type 1 myopia progression control lenses, the second with Type 2 myopia progression control lenses and the third continued to wear Conventional lenses for seven more days. All lenses had -10D central power, but Type 1 and Type 2 lenses had differing peripheral designs; +2.75D and +1.32D power rise at pupil edge, respectively. Axial length and refractive error were measured on Days 0, 7 and 14. Analyses were performed on the mean differences between treated and untreated eyes. Refractive error and axial length differences between treated and untreated eyes were insignificant on Day 0. On Day 7 treated eyes were longer (T1; 0.44 ± 0.07 mm, T2; 0.27 ± 0.06 mm, C; 0.40 ± 0.06 mm) and more myopic (T1; -9.61 ± 0.52D, T2; -9.57 ± 0.61D, C; -9.50 ± 0.58D) than untreated eyes with no significant differences between treatment groups. On Day 14 myopia was reversed (+2.91 ± 1.08D), reduced (-3.83 ± 0.94D) or insignificantly increased (-11.89 ± 0.79D) in treated eyes of Type 1, Type 2 and Conventional treated chicks respectively. Relative changes in axial lengths (T1; -0.13 ± 0.09 mm, T2; 0.36 ± 0.09 mm, C; 0.56 ± 0.05 mm) were consistent with changes in refraction. Refractive error differences were significant for all group comparisons (p < 0.001). Type 1 length differences were significantly different from Conventional and Type 2 groups (p < 0.001). Myopia progression control lens designs can reverse lens-induced myopia in chicks. The effect is primarily due to axial length changes. Different lens designs produce different effects indicating that lens design is important in modifying refractive error. © 2017 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists.

Design of Teacher Assistance Tools in an Exploratory Learning Environment for Algebraic Generalization

ERIC Educational Resources Information Center

Gutierrez-Santos, S.; Geraniou, E.; Pearce-Lazard, D.; Poulovassilis, A.

2012-01-01

The MiGen project is designing and developing an intelligent exploratory environment to support 11-14-year-old students in their learning of algebraic generalization. Deployed within the classroom, the system also provides tools to assist teachers in monitoring students' activities and progress. This paper describes the design of these Teacher…

Physical Environment as a 3-D Textbook: Design and Development of a Prototype

ERIC Educational Resources Information Center

Kong, Seng Yeap; Yaacob, Naziaty Mohd; Ariffin, Ati Rosemary Mohd

2015-01-01

The use of the physical environment as a three-dimensional (3-D) textbook is not a common practice in educational facilities design. Previous researches documented that little progress has been made to incorporate environmental education (EE) into architecture, especially among the conventional designers who are often constrained by the budget and…

A Framework for the Design of Computer-Assisted Simulation Training for Complex Police Situations

ERIC Educational Resources Information Center

Söderström, Tor; Åström, Jan; Anderson, Greg; Bowles, Ron

2014-01-01

Purpose: The purpose of this paper is to report progress concerning the design of a computer-assisted simulation training (CAST) platform for developing decision-making skills in police students. The overarching aim is to outline a theoretical framework for the design of CAST to facilitate police students' development of search techniques in…

Expanding the New Design: The NAEP 1985-86 Technical Report.

ERIC Educational Resources Information Center

Beaton, Albert E.; And Others

This report supplies details of the design and data analysis of the 1986 National Assessment of Educational Progress (NAEP) to allow the reader to judge the utility of the design, data quality, reasonableness of assumptions, appropriateness of data analyses, and generalizability of inferences made from the data. After an introduction by A. E.…

The Design of Phase II Clinical Trials Testing Cancer Therapeutics: Consensus Recommendations from the Clinical Trial Design Task Force of the National Cancer Institute Investigational Drug Steering Committee

PubMed Central

Seymour, Lesley; Ivy, S. Percy; Sargent, Daniel; Spriggs, David; Baker, Laurence; Rubinstein, Larry; Ratain, Mark J; Le Blanc, Michael; Stewart, David; Crowley, John; Groshen, Susan; Humphrey, Jeffrey S; West, Pamela; Berry, Donald

2010-01-01

The optimal design of phase II studies continues to be the subject of vigorous debate, especially with regards to studies of newer molecularly targeted agents. The observations that many new therapeutics ‘fail’ in definitive phase III studies, coupled with the numbers of new agents to be tested as well as the increasing costs and complexity of clinical trials further emphasizes the critical importance of robust and efficient phase II design. The Clinical Trial Design Task Force(CTD-TF)of the NCI Investigational Drug Steering Committee (IDSC) has published a series of discussion papers on Phase II trial design in Clinical Cancer Research. The IDSC has developed formal recommendations regarding aspects of phase II trial design which are the subject of frequent debate such as endpoints(response vs. progression free survival), randomization(single arm designs vs. randomization), inclusion of biomarkers, biomarker based patient enrichment strategies, and statistical design(e.g. two stage designs vs. multiple-group adaptive designs). While these recommendations in general encourage the use of progression-free survival as the primary endpoint, the use of randomization, the inclusion of biomarkers and the incorporation of newer designs, we acknowledge that objective response as an endpoint, and single arm designs, remain relevant in certain situations. The design of any clinical trial should always be carefully evaluated and justified based on the characteristic specific to the situation. PMID:20215557

Design of maintainable drains for earth retaining structures : final report and design guide.

DOT National Transportation Integrated Search

2017-04-01

Poor drainage is by far the most common cause of poor performance for earth retention systems. Poor performance includes burdensome serviceability problems that can progress to outright failure of the earth retention system if not addressed. : A comm...

Advanced Design Program (ARIES) Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tillack, Mark

2016-02-16

Progress is reported for the ARIES 3-year research program at UC San Diego, including three main tasks: 1. Completion of ARIES research on PMI/PFC issues. 2. Detailed engineering design and analysis of divertors and first wall/blankets. 3. Mission & requirements of FNSF.

Area estimation using multiyear designs and partial crop identification

NASA Technical Reports Server (NTRS)

Sielken, R. L., Jr.

1983-01-01

Progress is reported for the following areas: (1) estimating the stratum's crop acreage proportion using the multiyear area estimation model; (2) assessment of multiyear sampling designs; and (3) development of statistical methodology for incorporating partially identified sample segments into crop area estimation.

Promoting Student Progressions in Science Classrooms: A Video Study

ERIC Educational Resources Information Center

Jin, Hui; Johnson, Michele E.; Shin, Hyo Jeong; Anderson, Charles W.

2017-01-01

This study was conducted in a large-scale environmental literacy project. In the project, we developed a Learning Progression Framework (LPF) for matter and energy in social-ecological systems; the LPF contains four achievement levels. Based on the LPF, we designed a Plant Unit to help Levels 2 and 3 students advance to Level 4 of the LPF. In the…

The Progressive Era: The Limits of Reform. Public Issues Series.

ERIC Educational Resources Information Center

Giese, James R.

This booklet is part of a series designed to help students take and defend a position on public issues. In this unit, the progressive era, a major reform period in U.S. history that stretched from about 1900 to 1915 is discussed. The book suggests that large scale reform is difficult to achieve because reformers often assume that their interests,…

The Relationship between Individual Characteristics and Ideation Behavior: An Empirical Study of Storyboards

ERIC Educational Resources Information Center

Teng, Pei-Shan; Cai, Dengchuan; Yu, Tai-Kuei

2014-01-01

The development of digital technology tool and the progress of animation design activities have led to great progress in the animation field. The storyboard is a type of media used to present animator ideas. Therefore, it is commonly viewed as fundamental to the animation industry. This study aims to discuss cognitive style- and gender-based…

Evaluating the Progress of the School Reading Program. Learning Package No. 17.

ERIC Educational Resources Information Center

Nelson, Carol; Smith, Carl, Comp.

Originally developed for the Department of Defense Schools (DoDDS) system, this learning package on evaluating the progress of the school reading program is designed for teachers who wish to upgrade or expand their teaching skills on their own. The package includes a comprehensive search of the ERIC database; a lecture giving an overview on the…

Center for Information Services Fourth Quarterly Progress Report, Phase IIB; Detailed Design and Prototype Development, 1 October 1971 to 31 December 1971.

ERIC Educational Resources Information Center

Kehl, W. B.; And Others

The administrative activity, including organization, staff, budget and external contacts, and the technical progress of IPS development, experimental service, workshops, documentation and related activities of the Center for Information Services (at the University of California, Los Angeles) are reported upon in this document. Pages 9 and 10 may…

Civics Framework for the 1998 National Assessment of Educational Progress.

ERIC Educational Resources Information Center

Center for Civic Education, Calabasas, CA.

The material provides a comprehensive look at the design, goals, and methods to be used in the 1998 National Assessment of Educational Progress (NAEP) Civics Assessment. This assessment will attempt to gauge the civic knowledge and skills of the nation's 4th, 8th, and 12th grade students. To do well on the assessment, students will have to show…

State of the World, 1985: A Worldwatch Institute Report on Progress toward a Sustainable Society.

ERIC Educational Resources Information Center

Brown, Lester R.; And Others

The second of a series of annual reports designed to provide a global assessment of progress toward a sustainable society, this publication monitors changes in the global resource base (land, water, energy, and biological support systems), focusing particularly on how these changes affect the economy. Included in the report are news on innovative…

Maine Assessment of Educational Progress, Report 2. Results Report 1: Citizenship and Writing, 1972.

ERIC Educational Resources Information Center

Maine State Dept. of Educational and Cultural Services, Augusta.

The purpose of the Maine Assessment of Educational Progress (MAEP) in 1972 was to complete the first phase of a 10-year comprehensive needs assessment program involving students in public and non-public schools of the state. The total program is designed to provide specific information about knowledge, skills, understandings, and attitudes in 10…

Research, Development and Validation of the Daily Demand Computer Schedule 360/50. Final Report.

ERIC Educational Resources Information Center

Ovard, Glen F.; Rowley, Vernon C.

A study was designed to further the research, development and validation of the Daily Demand Computer Schedule (DDCS), a system by which students can be rescheduled daily for facilitating their individual continuous progress through the curriculum. It will allow teachers to regroup students as needed based upon that progress, and will make time a…

Progress Monitoring Using Direct Behavior Rating Single Item Scales in a Multiple-Baseline Design Study of the Daily Report Card Intervention

ERIC Educational Resources Information Center

Fabiano, Gregory A.; Pyle, Kellina; Kelty, Mary Bridget; Parham, Brittany R.

2017-01-01

Direct behavior rating (DBR) may be a viable assessment for documenting current areas of impaired functioning and progress monitoring students' response to a behavioral intervention. Challenging behaviors are often addressed in general education settings using interventions such as the daily report card (DRC). To best implement and monitor such…

25 CFR 900.132 - Once a contract and/or grant is awarded, how will the Indian tribe or tribal organization receive...

Code of Federal Regulations, 2010 CFR

2010-04-01

... schedule for advance payments shall be developed based on progress, need, and other considerations in... project based on progress and need. (b) Payments shall be made to the Indian tribe or tribal organization... amounts measured by time or measured by phase of the project (e.g., planning, design, construction). (d...

Assessment of the Continuous Progress Report for the Early Learning Years (An Examination of Scale Construction).

ERIC Educational Resources Information Center

Tuck, Kathy D.

An evaluation was conducted to examine the structure and design of the Continuous Progress Report (CPR), an observation scale used to measure students' early developmental skills in the District of Columbia public schools. Item construction and the relative consistency of measurement constructs in the CPR were the specific focus of the evaluation.…

The Achievement Progress of English Learner Students in Utah. REL 2016-155

ERIC Educational Resources Information Center

Haas, Eric; Huang, Min; Tran, Loan; Yu, Airong

2016-01-01

The purpose of this study was to examine the cumulative progress of English learner students in Utah in English language proficiency (ELP) and in academic content knowledge in both English language arts (ELA) and mathematics. This study identified students in grades kindergarten, 3, and 6 who were designated as English learner students in 2006/07…

Implementation of the K-12 Education Reform in Qatar's Schools. Monograph

ERIC Educational Resources Information Center

Zellman, Gail L.; Ryan Gery W.; Karam, Rita; Constant, Louay; Salem, Hanine; Gonzalez, Gabriella; Orr, Nate; Goldman, Charles A.; Al-Thani, Hessa; Al-Obaidli, Kholode

2009-01-01

The leadership of Qatar is greatly invested in its K-12 education reform, "Education for a New Era," because it views education as the key to the nation's economic and social progress. This study, one of a number of RAND studies that trace and document the reform process in Qatar, was designed to assess progress made in the first years…

Analyzing Students' Learning Progressions throughout a Teaching Sequence on Acoustic Properties of Materials with a Model-Based Inquiry Approach

ERIC Educational Resources Information Center

Hernández, María Isabel; Couso, Digna; Pintó, Roser

2015-01-01

The study we have carried out aims to characterize 15-to 16-year-old students' learning progressions throughout the implementation of a teaching-learning sequence on the acoustic properties of materials. Our purpose is to better understand students' modeling processes about this topic and to identify how the instructional design and actual…

The Nation's Report Card: Science 2011. National Assessment of Educational Progress at Grade 8. NCES 2012-465

ERIC Educational Resources Information Center

National Center for Education Statistics, 2012

2012-01-01

This report presents results of the National Assessment of Educational Progress (NAEP) U.S. science assessment in 2011. A representative sample of 122,000 eighth-graders participated in the 2011 NAEP science assessment, which is designed to measure students' knowledge and abilities in the areas of physical science, life science, and Earth and…

Assessing the progress of rehabilitation in patients with ACL reconstruction using the International Knee Documentation Committee Subjective Knee Form

NASA Astrophysics Data System (ADS)

Leguizamon, J. H.; Braidot, A.; Catalfamo Formento, P.

2011-12-01

There are numerous assessment tools designed to provide information on the results of reconstructive surgery of anterior cruciate ligament (ACL). They are also used for monitoring progress and facilitating clinical decision-making during the rehabilitation process. A brief summary of some existing tools specifically designed to evaluate knee ligament injuries is presented in this article. Then, one of those outcome measures, the International Knee Documentation Committee Subjective Knee Form (IKDC) was applied to a group of patients (N = 10) who had undergone surgery for ACL reconstruction. The patients attended the same physiotherapy service and followed a unified rehabilitation protocol. The assessment was performed twice: four and six months after surgery. The results showed an improvement in the rehabilitation of most patients tested (verified by a difference equal to or greater than 9 points on the IKDC outcome between measurements 1 and 2). The IKDC probed to be an instrument of quick and easy application. It provided quantitative data about the progress of rehabilitation and could be applied in everyday clinical physiotherapy practice. However, the results suggested considering the IKDC as one component of an evaluation kit to make decisions regarding the progress of the rehabilitation treatment.

Hybrid antibiotics - clinical progress and novel designs.

PubMed

Parkes, Alastair L; Yule, Ian A

2016-07-01

There is a growing need for new antibacterial agents, but success in development of antibiotics in recent years has been limited. This has led researchers to investigate novel approaches to finding compounds that are effective against multi-drug resistant bacteria, and that delay onset of resistance. One such strategy has been to link antibiotics to produce hybrids designed to overcome resistance mechanisms. The concept of dual-acting hybrid antibiotics was introduced and reviewed in this journal in 2010. In the present review the authors sought to discover how clinical candidates described had progressed, and to examine how the field has developed. In three sections the authors cover the clinical progress of hybrid antibiotics, novel agents produced from hybridisation of two or more small-molecule antibiotics, and novel agents produced from hybridisation of antibiotics with small-molecules that have complementary activity. Many key questions regarding dual-acting hybrid antibiotics remain to be answered, and the proposed benefits of this approach are yet to be demonstrated. While Cadazolid in particular continues to progress in the clinic, suggesting that there is promise in hybridisation through covalent linkage, it may be that properties other than antibacterial activity are key when choosing a partner molecule.

Assessment of Individuals with Primary Progressive Aphasia.

PubMed

Henry, Maya L; Grasso, Stephanie M

2018-07-01

Speech-language pathologists play a crucial role in the assessment and treatment of individuals with primary progressive aphasia (PPA). The speech-language evaluation is a critical aspect of the diagnostic and rehabilitative process, informing differential diagnosis as well as intervention planning and monitoring of cognitive-linguistic status over time. The evaluation should include a thorough case history and interview and a detailed assessment of speech-language and cognitive functions, with tasks designed to detect core and associated deficits outlined in current diagnostic criteria. In this paper, we review assessments that can be utilized to examine communication and cognition in PPA, including general aphasia batteries designed for stroke and/or progressive aphasia as well as tests of specific cognitive-linguistic functions, including naming, object/person knowledge, single-word and sentence comprehension, repetition, spontaneous speech/language production, motor speech, written language, and nonlinguistic cognitive domains. The comprehensive evaluation can inform diagnostic decision making and facilitate planning of interventions that are tailored to the patient's current status and likely progression of deficits. As such, the speech-language evaluation allows the medical team to provide individuals with PPA and their families with appropriate recommendations for the present and the future. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Building Capacity in Understanding Foundational Biology Concepts: A K-12 Learning Progression in Genetics Informed by Research on Children's Thinking and Learning

NASA Astrophysics Data System (ADS)

Elmesky, Rowhea

2013-06-01

This article describes the substance, structure, and rationale of a learning progression in genetics spanning kindergarten through twelfth grade (K-12). The learning progression is designed to build a foundation towards understanding protein structure and activity and should be viewed as one possible pathway to understanding concepts of genetics and ultimately protein expression, based on the existing research. The kindergarten through fifth grade segment reflects findings that show children have a rich knowledge base and sophisticated cognitive abilities, and therefore, is designed so that elementary-aged children can learn content in deep and abstract manners, as well as apply scientific explanations appropriate to their knowledge level. The article also details the LP segment facilitating secondary students' understanding by outlining the overlapping conceptual frames which guide student learning from cell structures and functions to cell splitting (both cell division and gamete formation) to genetics as trait transmission, culminating in genetics as protein expression. The learning progression product avoids the use of technical language, which has been identified as a prominent source of student misconceptions in learning cellular biology, and explicit connections between cellular and macroscopic phenomena are encouraged.

Optimal filter design with progressive genetic algorithm for local damage detection in rolling bearings

NASA Astrophysics Data System (ADS)

Wodecki, Jacek; Michalak, Anna; Zimroz, Radoslaw

2018-03-01

Harsh industrial conditions present in underground mining cause a lot of difficulties for local damage detection in heavy-duty machinery. For vibration signals one of the most intuitive approaches of obtaining signal with expected properties, such as clearly visible informative features, is prefiltration with appropriately prepared filter. Design of such filter is very broad field of research on its own. In this paper authors propose a novel approach to dedicated optimal filter design using progressive genetic algorithm. Presented method is fully data-driven and requires no prior knowledge of the signal. It has been tested against a set of real and simulated data. Effectiveness of operation has been proven for both healthy and damaged case. Termination criterion for evolution process was developed, and diagnostic decision making feature has been proposed for final result determinance.

Cost analysis of oxygen recovery systems

NASA Technical Reports Server (NTRS)

Yakut, M. M.

1973-01-01

The design and development of equipment for flight use in earth-orbital programs, when optimally approached cost effectively, proceed through the following logical progression: (1) bench testing of breadboard designs, (2) the fabrication and evaluation of prototype equipment, (3) redesign to meet flight-imposed requirements, and (4) qualification and testing of a flight-ready system. Each of these steps is intended to produce the basic design information necessary to progress to the next step. The cost of each step is normally substantially less than that of the following step. An evaluation of the cost elements involved in each of the steps and their impact on total program cost are presented. Cost analyses of four leading oxygen recovery subsystems which include two carbon dioxide reduction subsystem, Sabatier and Bosch, and two water electrolysis subsystems, the solid polymer electrolyte and the circulating KOH electrolyte are described.

Recent progress of RD53 Collaboration towards next generation Pixel Read-Out Chip for HL-LHC

DOE PAGES

Demaria, N.

2016-12-21

This paper is a review of recent progress of RD53 Collaboration. Results obtained on the study of the radiation effects on 65 nm CMOS have matured enough to define first strategies to adopt in the design of analog and digital circuits. Critical building blocks and analog very front end chains have been designed, tested before and after 5–800 Mrad. Small prototypes of 64×64 pixels with complex digital architectures have been produced, and point to address the main issues of dealing with extremely high pixel rates, while operating at very small in-time thresholds in the analog front end. Lastly, the collaborationmore » is now proceeding at full speed towards the design of a large scale prototype, called RD53A, in 65 nm CMOS technology.« less

Designing for fiber composite structural durability in hygrothermomechanical environment

NASA Technical Reports Server (NTRS)

Chamis, C. C.

1985-01-01

A methodology is described which can be used to design/analyze fiber composite structures subjected to complex hygrothermomechanical environments. This methodology includes composite mechanics and advanced structural analysis methods (finite element). Select examples are described to illustrate the application of the available methodology. The examples include: (1) composite progressive fracture; (2) composite design for high cycle fatigue combined with hot-wet conditions; and (3) general laminate design.

Making It Work for Everyone: HTML5 and CSS Level 3 for Responsive, Accessible Design on Your Library's Web Site

ERIC Educational Resources Information Center

Baker, Stewart C.

2014-01-01

This article argues that accessibility and universality are essential to good Web design. A brief review of library science literature sets the issue of Web accessibility in context. The bulk of the article explains the design philosophies of progressive enhancement and responsive Web design, and summarizes recent updates to WCAG 2.0, HTML5, CSS…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klein, Steven Karl; Day, Christy M.; Determan, John C.

LANL has developed a process to generate a progressive family of system models for a fissile solution system. This family includes a dynamic system simulation comprised of coupled nonlinear differential equations describing the time evolution of the system. Neutron kinetics, radiolytic gas generation and transport, and core thermal hydraulics are included in the DSS. Extensions to explicit operation of cooling loops and radiolytic gas handling are embedded in these systems as is a stability model. The DSS may then be converted to an implementation in Visual Studio to provide a design team the ability to rapidly estimate system performance impactsmore » from a variety of design decisions. This provides a method to assist in optimization of the system design. Once design has been generated in some detail the C++ version of the system model may then be implemented in a LabVIEW user interface to evaluate operator controls and instrumentation and operator recognition and response to off-normal events. Taken as a set of system models the DSS, Visual Studio, and LabVIEW progression provides a comprehensive set of design support tools.« less

Design and progress report for compact cryocooled sapphire oscillator 'VCSO'

NASA Technical Reports Server (NTRS)

Dick, G. John; Wang, Rabi T.; Tjoelker, Robert L.

2005-01-01

We report on the development of a compact cryocooled sapphiere oscillator 'VCSO', designed as a higher-performance replacement for ultra-stable quartz oscillators in local oscillator, cleanup, and flywheel applications in the frequency generation and distribution subsystems of NASA's Deep Space Network (DSN).

An Airplane Design having a Wing with Fuselage Attached to Each Tip

NASA Technical Reports Server (NTRS)

Spearman, Leroy M.

2001-01-01

This paper describes the conceptual design of an airplane having a low aspect ratio wing with fuselages that are attached to each wing tip. The concept is proposed for a high-capacity transport as an alternate to progressively increasing the size of a conventional transport design having a single fuselage with cantilevered wing panels attached to the sides and tail surfaces attached at the rear. Progressively increasing the size of conventional single body designs may lead to problems in some area's such as manufacturing, ground-handling and aerodynamic behavior. A limited review will be presented of some past work related to means of relieving some size constraints through the use of multiple bodies. Recent low-speed wind-tunnel tests have been made of models representative of the inboard-wing concept. These models have a low aspect ratio wing with a fuselage attached to each tip. Results from these tests, which included force measurements, surface pressure measurements, and wake surveys, will be presented herein.

Progress in FMIT test assembly development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Opperman, E.K.; Vogel, M.A.; Shen, E.J.

Research and development supporting the completed design of the Fusion Materials Irradiation Test (FMIT) Facility is continuing at the Hanford Engineering Development Laboratory (HEDL) in Richland, Washington. The FMIT, a deuteron accelerator based (d + Li) neutron source, will produce an intense flux of high energy neutrons for use in radiation damage studies of fusion reactor materials. The most intense flux magnitude of greater than 10/sup 15/ n/cm/sup 2/-s is located close to the neutron producing lithium target and is distributed within a volume about the size of an American football. The conceptual design and development of FMIT experiments calledmore » Test Assemblies has progressed over the past five years in parallel with the design of the FMIT. The paper will describe the recent accomplishments made in developing test assemblies appropriate for use in the limited volume close to the FMIT target where high neutron flux and heating rates and the associated spacial gradients significantly impact design considerations.« less

Computational Aeroelastic Modeling of Airframes and TurboMachinery: Progress and Challenges

NASA Technical Reports Server (NTRS)

Bartels, R. E.; Sayma, A. I.

2006-01-01

Computational analyses such as computational fluid dynamics and computational structural dynamics have made major advances toward maturity as engineering tools. Computational aeroelasticity is the integration of these disciplines. As computational aeroelasticity matures it too finds an increasing role in the design and analysis of aerospace vehicles. This paper presents a survey of the current state of computational aeroelasticity with a discussion of recent research, success and continuing challenges in its progressive integration into multidisciplinary aerospace design. This paper approaches computational aeroelasticity from the perspective of the two main areas of application: airframe and turbomachinery design. An overview will be presented of the different prediction methods used for each field of application. Differing levels of nonlinear modeling will be discussed with insight into accuracy versus complexity and computational requirements. Subjects will include current advanced methods (linear and nonlinear), nonlinear flow models, use of order reduction techniques and future trends in incorporating structural nonlinearity. Examples in which computational aeroelasticity is currently being integrated into the design of airframes and turbomachinery will be presented.

Design progress of the solar UV-Vis-IR telescope (SUVIT) aboard SOLAR-C

NASA Astrophysics Data System (ADS)

Katsukawa, Y.; Ichimoto, K.; Suematsu, Y.; Hara, H.; Kano, R.; Shimizu, T.; Matsuzaki, K.

2013-09-01

We present a design progress of the Solar UV-Vis-IR Telescope (SUVIT) aboard the next Japanese solar mission SOLAR-C. SUVIT has an aperture diameter of ~1.4 m for achieving spectro-polarimetric observations with spatial and temporal resolution exceeding the Hinode Solar Optical Telescope (SOT). We have studied structural and thermal designs of the optical telescope as well as the optical interface between the telescope and the focal plane instruments. The focal plane instruments are installed into two packages, filtergraph and spectrograph packages. The spectropolarimeter is the instrument dedicated to accurate polarimetry in the three spectrum windows at 525 nm, 854 nm, and 1083 nm for observing magnetic fields at both the photospheric and chromospheric layers. We made optical design of the spectrograph accommodating the conventional slit spectrograph and the integral field unit (IFU) for two-dimensional coverage. We are running feasibility study of the IFU using fiber arrays consisting of rectangular cores.

SP-100 - The national space reactor power system program in response to future needs

NASA Astrophysics Data System (ADS)

Armijo, J. S.; Josloff, A. T.; Bailey, H. S.; Matteo, D. N.

The SP-100 system has been designed to meet comprehensive and demanding NASA/DOD/DOE requirements. The key requirements include: nuclear safety for all mission phases, scalability from 10's to 100's of kWe, reliable performance at full power for seven years of partial power for ten years, survivability in civil or military threat environments, capability to operate autonomously for up to six months, capability to protect payloads from excessive radiation, and compatibility with shuttle and expendable launch vehicles. The authors address of major progress in terms of design, flexibility/scalability, survivability, and development. These areas, with the exception of survivability, are discussed in detail. There has been significant improvement in the generic flight system design with substantial mass savings and simplification that enhance performance and reliability. Design activity has confirmed the scalability and flexibility of the system and the ability to efficiently meet NASA, AF, and SDIO needs. SP-100 development continues to make significant progress in all key technology areas.

Head-Up; An interdisciplinary, participatory and co-design process informing the development of a novel head and neck support for people living with progressive neck muscle weakness.

PubMed

Reed, Heath; Langley, Joe; Stanton, Andy; Heron, Nicola; Clarke, Zoe; Judge, Simon; McCarthy, Avril; Squire, Gill; Quinn, Ann; Wells, Oliver; Tindale, Wendy; Baxter, Susan; Shaw, Pamela J; McDermott, Christopher J

2014-01-01

This paper presents the Head-Up project, that aims to provide innovative head support to help improve posture, relieve pain and aid communication for people living with progressive neck muscle weakness. The initial focus is motor neurone disease. The case study illustrates collaborative, interdisciplinary research and new product development underpinned by participatory design. The study was initiated by a 2-day stakeholder workshop followed by early proof-of-concept modelling and patient need evidence building. The work subsequently led to a successful NIHR i4i application funding a 24-month iterative design process, patenting, CE marking and clinical evaluation. The evaluation has informed amendments to the proposed design refered to here as the Sheffield Support Snood (SSS). The outcome positively demonstrates use and performance improvements over current neck orthoses and the process of multidisciplinary and user engagement has created a sense of ownership by MND participants, who have since acted as advocates for the product.

Concept Car Design and Ability Training

NASA Astrophysics Data System (ADS)

Lv, Jiefeng; Lu, Hairong

The concept design as a symbol of creative design thinking, reflecting on the future design of exploratory and prospective, as a vehicle to explore the notion of future car design, design inspiration and creativity is not only a bold display, more through demonstrate the concept, reflects the company's technological strength and technological progress, and thus enhance their brand image. Present Chinese automobile design also has a very big disparity with world level, through cultivating students' concept design ability, to establish native design features and self-reliant brand image is practical and effective ways, also be necessary and pressing.

Space Fabrication Demonstration System

NASA Technical Reports Server (NTRS)

1977-01-01

Progress in the development of a beam builder to be deployed by space shuttle for assembly of large structures in space is reported. The thermal coating for the structural truss was selected and the detail truss design and analysis completed. Data acquired during verification of the design of the basic 'building block' truss are included as well as design layouts for various fabrication facility subsystems.

Design and control considerations for industrial and space manipulators

NASA Technical Reports Server (NTRS)

Whitney, D. E.; Book, W. J.; Lynch, P. M.

1974-01-01

This paper is a progress report summarizing theoretical and practical results concerning integration of design and control aspects of manipulator arms for industrial or space applications. The relationships between task specifications, gross motions, fine motions, actuator type and location, size and strength of structural members, control servos and strategies, and overall design evaluation are briefly discussed, with some technical examples.

Final definition and preliminary design study for the initial atmospheric cloud physics laboratory, a spacelab mission payload

NASA Technical Reports Server (NTRS)

1976-01-01

The Atmospheric Cloud Physics Laboratory (ACPL) task flow is shown. Current progress is identified. The requirements generated in task 1 have been used to formulate an initial ACPL baseline design concept. ACPL design/functional features are illustrated. A timetable is presented of the routines for ACPL integration with the spacelab system.

Learntime and Learning Place-Focused Forward-Oriented Design for Learning in Technology-Enhanced Classrooms

ERIC Educational Resources Information Center

Sun, Susan Y. H.

2016-01-01

This study reports on a teacher's ongoing design activities in a fully online language course when the class was in progress. The aims were, firstly, to provide first-hand experience and insight into a teacher's design work in a real-life, technology-enhanced learning (TEL) classroom; and secondly, to facilitate reflective analysis of the emerging…

MFTF-. cap alpha. + T progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, W.D.

1985-04-01

Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; theymore » will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.« less

Progress making the top end optical assembly (TEOA) for the 4-meter Advanced Technology Solar Telescope

NASA Astrophysics Data System (ADS)

Canzian, Blaise; Barentine, J.; Arendt, J.; Bader, S.; Danyo, G.; Heller, C.

2012-09-01

L-3 Integrated Optical Systems (IOS) Division has been selected by the National Solar Observatory (NSO) to design and produce the Top End Optical Assembly (TEOA) for the 4-meter Advanced Technology Solar Telescope (ATST) to operate at Haleakal', Maui. ATST will perform to a very high optical performance level in a difficult thermal environment. The TEOA, containing the 0.65-meter silicon carbide secondary mirror and support, mirror thermal management system, mirror positioning and fast tip-tilt system, field stop with thermally managed heat dump, thermally managed Lyot stop, safety interlock and control system, and support frame, operates in the "hot spot" at the prime focus of the ATST and so presents special challenges. In this paper, we describe progress in the L-3 technical approach to meeting these challenges, including silicon carbide off-axis mirror design, fabrication, and high accuracy figuring and polishing all within L-3; mirror support design; the design for stray light control; subsystems for opto-mechanical positioning and high accuracy absolute mirror orientation sensing; Lyot stop design; and thermal management of all design elements to remain close to ambient temperature despite the imposed solar irradiance load.

Instrumentation progress at the Giant Magellan Telescope project

NASA Astrophysics Data System (ADS)

Jacoby, George H.; Bernstein, R.; Bouchez, A.; Colless, M.; Crane, Jeff; DePoy, D.; Espeland, B.; Hare, Tyson; Jaffe, D.; Lawrence, J.; Marshall, J.; McGregor, P.; Shectman, Stephen; Sharp, R.; Szentgyorgyi, A.; Uomoto, Alan; Walls, B.

2016-08-01

Instrument development for the 24m Giant Magellan Telescope (GMT) is described: current activities, progress, status, and schedule. One instrument team has completed its preliminary design and is currently beginning its final design (GCLEF, an optical 350-950 nm, high-resolution and precision radial velocity echelle spectrograph). A second instrument team is in its conceptual design phase (GMACS, an optical 350-950 nm, medium resolution, 6-10 arcmin field, multi-object spectrograph). A third instrument team is midway through its preliminary design phase (GMTIFS, a near-IR YJHK diffraction-limited imager/integral-field-spectrograph), focused on risk reduction prototyping and design optimization. A fourth instrument team is currently fabricating the 5 silicon immersion gratings needed to begin its preliminary design phase (GMTNIRS, a simultaneous JHKLM high-resolution, AO-fed, echelle spectrograph). And, another instrument team is focusing on technical development and prototyping (MANIFEST, a facility robotic, multifiber feed, with a 20 arcmin field of view). In addition, a medium-field (6 arcmin, 0.06 arcsec/pix) optical imager will support telescope and AO commissioning activities, and will excel at narrow-band imaging. In the spirit of advancing synergies with other groups, the challenges of running an ELT instrument program and opportunities for cross-ELT collaborations are discussed.

Disease progression model in subjects with mild cognitive impairment from the Alzheimer's disease neuroimaging initiative: CSF biomarkers predict population subtypes

PubMed Central

Samtani, Mahesh N; Raghavan, Nandini; Shi, Yingqi; Novak, Gerald; Farnum, Michael; Lobanov, Victor; Schultz, Tim; Yang, Eric; DiBernardo, Allitia; Narayan, Vaibhav A

2013-01-01

AIM The objective is to develop a semi-mechanistic disease progression model for mild cognitive impairment (MCI) subjects. The model aims to describe the longitudinal progression of ADAS-cog scores from the Alzheimer's disease neuroimaging initiative trial that had data from 198 MCI subjects with cerebrospinal fluid (CSF) information who were followed for 3 years. METHOD Various covariates were tested on disease progression parameters and these variables fell into six categories: imaging volumetrics, biochemical, genetic, demographic, cognitive tests and CSF biomarkers. RESULTS CSF biomarkers were associated with both baseline disease score and disease progression rate in subjects with MCI. Baseline disease score was also correlated with atrophy measured using hippocampal volume. Progression rate was also predicted by executive functioning as measured by the Trail B-test. CONCLUSION CSF biomarkers have the ability to discriminate MCI subjects into sub-populations that exhibit markedly different rates of disease progression on the ADAS-cog scale. These biomarkers can therefore be utilized for designing clinical trials enriched with subjects that carry the underlying disease pathology. PMID:22534009

Classifying the Progression of Ductal Carcinoma from Single-Cell Sampled Data via Integer Linear Programming: A Case Study

PubMed Central

Catanzaro, Daniele; Schäffer, Alejandro A.; Schwartz, Russell

2016-01-01

Ductal Carcinoma In Situ (DCIS) is a precursor lesion of Invasive Ductal Carcinoma (IDC) of the breast. Investigating its temporal progression could provide fundamental new insights for the development of better diagnostic tools to predict which cases of DCIS will progress to IDC. We investigate the problem of reconstructing a plausible progression from single-cell sampled data of an individual with Synchronous DCIS and IDC. Specifically, by using a number of assumptions derived from the observation of cellular atypia occurring in IDC, we design a possible predictive model using integer linear programming (ILP). Computational experiments carried out on a preexisting data set of 13 patients with simultaneous DCIS and IDC show that the corresponding predicted progression models are classifiable into categories having specific evolutionary characteristics. The approach provides new insights into mechanisms of clonal progression in breast cancers and helps illustrate the power of the ILP approach for similar problems in reconstructing tumor evolution scenarios under complex sets of constraints. PMID:26353381

Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses.

PubMed

Giovannoni, Gavin; Cutter, Gary; Sormani, Maria Pia; Belachew, Shibeshih; Hyde, Robert; Koendgen, Harold; Knappertz, Volker; Tomic, Davorka; Leppert, David; Herndon, Robert; Wheeler-Kingshott, Claudia A M; Ciccarelli, Olga; Selwood, David; di Cantogno, Elisabetta Verdun; Ben-Amor, Ali-Frederic; Matthews, Paul; Carassiti, Daniele; Baker, David; Schmierer, Klaus

2017-02-01

Trials of anti-inflammatory therapies in non-relapsing progressive multiple sclerosis (MS) have been stubbornly negative except recently for an anti-CD20 therapy in primary progressive MS and a S1P modulator siponimod in secondary progressive MS. We argue that this might be because trials have been too short and have focused on assessing neuronal pathways, with insufficient reserve capacity, as the core component of the primary outcome. Delayed neuroaxonal degeneration primed by prior inflammation is not expected to respond to disease-modifying therapies targeting MS-specific mechanisms. However, anti-inflammatory therapies may modify these damaged pathways, but with a therapeutic lag that may take years to manifest. Based on these observations we propose that clinically apparent neurodegenerative components of progressive MS may occur in a length-dependent manner and asynchronously. If this hypothesis is confirmed it may have major implications for the future design of progressive MS trials. Copyright © 2016 Elsevier B.V. All rights reserved.

Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

PubMed

Nakanishi, Rine; Post, Wendy S; Osawa, Kazuhiro; Jayawardena, Eranthi; Kim, Michael; Sheidaee, Nasim; Nezarat, Negin; Rahmani, Sina; Kim, Nicholas; Hathiramani, Nicolai; Susarla, Shriraj; Palella, Frank; Witt, Mallory; Blaha, Michael J; Brown, Todd T; Kingsley, Lawrence; Haberlen, Sabina A; Dailing, Christopher; Budoff, Matthew J

2018-01-01

The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time. We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.

Classifying the Progression of Ductal Carcinoma from Single-Cell Sampled Data via Integer Linear Programming: A Case Study.

PubMed

Catanzaro, Daniele; Shackney, Stanley E; Schaffer, Alejandro A; Schwartz, Russell

2016-01-01

Ductal Carcinoma In Situ (DCIS) is a precursor lesion of Invasive Ductal Carcinoma (IDC) of the breast. Investigating its temporal progression could provide fundamental new insights for the development of better diagnostic tools to predict which cases of DCIS will progress to IDC. We investigate the problem of reconstructing a plausible progression from single-cell sampled data of an individual with synchronous DCIS and IDC. Specifically, by using a number of assumptions derived from the observation of cellular atypia occurring in IDC, we design a possible predictive model using integer linear programming (ILP). Computational experiments carried out on a preexisting data set of 13 patients with simultaneous DCIS and IDC show that the corresponding predicted progression models are classifiable into categories having specific evolutionary characteristics. The approach provides new insights into mechanisms of clonal progression in breast cancers and helps illustrate the power of the ILP approach for similar problems in reconstructing tumor evolution scenarios under complex sets of constraints.

Ongoing Progress in Spacecraft Controls

NASA Technical Reports Server (NTRS)

Ghosh, Dave (Editor)

1992-01-01

This publication is a collection of papers presented at the Mars Mission Research Center workshop on Ongoing Progress in Spacecraft Controls. The technical program addressed additional Mars mission control problems that currently exist in robotic missions in addition to human missions. Topics include control systems design in the presence of large time delays, fuel-optimal propulsive control, and adaptive control to handle a variety of unknown conditions.

NAEP 1996 Science State Report for Connecticut. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Mississippi. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Indiana. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Wisconsin. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Nevada. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for North Carolina. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Georgia. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Texas. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Colorado. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Delaware. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Hawaii. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for New Hampshire. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Alabama. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Florida. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for West Virginia. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Arizona. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Maine. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Wyoming. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Tennessee. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

High Resolution Analysis of Copy Number Mutation in Breast Cancer

DTIC Science & Technology

2005-05-01

tissues and Epstein - Barr sentations and arrays of Hind III probes additional CNPs, as would an increase in the virus -immortalized lymphoblastoid cell...software and laboratory procedures for the design of inter-phase FISH primers. We have also made progress in developing database and data processing...Cancer progression often involves alterations in DNA copy number. Newly developed microarray technologies enable simultane- ous measurement of copy

Women in American History: A Series. Book Four, Women in the Progressive Era 1890-1920.

ERIC Educational Resources Information Center

Sanders, Beverly

The document, one in a series of four on women in American history, discusses the role of women in the Progressive Era (1890-1920). Designed to supplement high school U.S. history textbooks, the book is comprised of five chapters. Chapter I describes reformers and radicals including Jane Addams and Lillian Wald who began the settlement house…

Monitoring Indicators of Scholarly Language: A Progress-Monitoring Instrument for Measuring Narrative Discourse Skills

ERIC Educational Resources Information Center

Gillam, Sandra Laing; Gillam, Ronald B.; Fargo, Jamison D.; Olszewski, Abbie; Segura, Hugo

2017-01-01

The purpose of this study was to assess the basic psychometric properties of a progress-monitoring tool designed to measure narrative discourse skills in school-age children with language impairments (LI). A sample of 109 children with LI between the ages of 5 years 7 months and 9 years 9 months completed the "Test of Narrative Language"…

The Nation's Report Card: A First Look--2013 Mathematics and Reading. National Assessment of Educational Progress at Grades 4 and 8. NCES 2014-451

ERIC Educational Resources Information Center

National Center for Education Statistics, 2013

2013-01-01

The National Assessment of Educational Progress (NAEP) mathematics assessment measures students' knowledge and skills in mathematics and students' ability to apply their knowledge in problem-solving situations. At each grade, students responded to questions designed to measure what they know and can do across five mathematics content areas: number…

Designing Unmanned Systems with Greater Autonomy: Using a Federated, Partially Open Systems Architecture Approach

DTIC Science & Technology

2014-01-01

system UAV unmanned aircraft vehicle UCI User -Computer Interface UCS UAS control segment Abbreviations xxix UGS unmanned ground system UGV unmanned ...made substantial progress in the deployment of more capable sensors, unmanned aircraft systems (UAS), and other unmanned systems (UxS). Innovative...progress in fielding more, and more capable unmanned aircraft systems (UAS) to meet the needs of warfighters

Programmatic Research to Develop and Disseminate Improved Instructional Technology for Handicapped Children. Project MORE Quarterly Progress Report, September 1 to December 1, 1972.

ERIC Educational Resources Information Center

Schiefelbusch, Richard L.; Lent, James R.

During the past reporting period the curriculum development staff of Project MORE (Mediated Operational Research for Education) has made substantial progress in attaining its program objectives. Design and development phases have proceeded on schedule. Four programs are currently in the field-testing stage, and four others are under development.…

Radioecology of natural systems in Colordao. Fourteenth annual progress report, May 1, 1975--July 31, 1976. [Pu diffusion in terrestrial ecosystems at Rocky Flats Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whicker, F.W.

1976-08-01

This report summarizes project activities during the period May 1, 1975 through July 31, 1976. The major study on the distribution and levels of Pu in major components of the terrestrial ecosystem at Rocky Flats was completed. Supportive studies on the ecology and pathology of small mammals and their role in Pu transport were essentially completed as well. Detailed studies on mule deer food habits, population dynamics, and movements at Rocky Flats are progressing. These studies are designed to measure the potential of mule deer in transporting Pu to uncontrolled areas. Alpha autoradiographic studies designed to measure Pu particle sizemore » and distribution and spatial patterns in soil were initiated. Field and greenhouse transport pathways from soil to vegetation are in progress and some early results reported. The status of studies on seasonal kinetics of Cs in a montane lake and stable lead geochemistry in an alpine lake watershed are also reported.« less

Experimental Verification of a Progressive Damage Model for IM7/5260 Laminates Subjected to Tension-Tension Fatigue

NASA Technical Reports Server (NTRS)

Coats, Timothy W.; Harris, Charles E.

1995-01-01

The durability and damage tolerance of laminated composites are critical design considerations for airframe composite structures. Therefore, the ability to model damage initiation and growth and predict the life of laminated composites is necessary to achieve structurally efficient and economical designs. The purpose of this research is to experimentally verify the application of a continuum damage model to predict progressive damage development in a toughened material system. Damage due to monotonic and tension-tension fatigue was documented for IM7/5260 graphite/bismaleimide laminates. Crack density and delamination surface area were used to calculate matrix cracking and delamination internal state variables to predict stiffness loss in unnotched laminates. A damage dependent finite element code predicted the stiffness loss for notched laminates with good agreement to experimental data. It was concluded that the continuum damage model can adequately predict matrix damage progression in notched and unnotched laminates as a function of loading history and laminate stacking sequence.

Design and fabrication of a high temperature leading edge heating array, phase 1

NASA Technical Reports Server (NTRS)

1972-01-01

Progress during a Phase 1 program to design a high temperature heating array is reported for environmentally testing full-scale shuttle leading edges (30 inch span, 6 to 15 inch radius) at flight heating rates and pressures. Heat transfer analyses of the heating array, individual modules, and the shuttle leading edge were performed, which influenced the array design, and the design, fabrication, and testing of a prototype heater module.

Design, Progressive Modeling, Manufacture, and Testing of Composite Shield for Turbine Engine Blade Containment

NASA Technical Reports Server (NTRS)

Binienda, Wieslaw K.; Sancaktar, Erol; Roberts, Gary D. (Technical Monitor)

2002-01-01

An effective design methodology was established for composite jet engine containment structures. The methodology included the development of the full and reduced size prototypes, and FEA models of the containment structure, experimental and numerical examination of the modes of failure clue to turbine blade out event, identification of materials and design candidates for future industrial applications, and design and building of prototypes for testing and evaluation purposes.

Project Summaries, 1989 - 1990

NASA Technical Reports Server (NTRS)

1990-01-01

Student designs summarized here include two undergraduate space designs and five graduate space designs from fall 1989, plus four undergraduate space designs and four undergraduate aircraft designs from spring 1990. Progress in a number of programs is described. The Geostationary Satellite Servicing Facility, the Lunar Farside Observatory and Science Base, the Texas Educational Satellite, an asteroid rendezvous vehicle, a Titan probe, a subsystems commonality assessment for lunar/Mars landers, a nuclear-thermal rocket propelled Earth-Mars vehicle, and a comprehensive orbital debris management program are among the topics discussed.

Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

PubMed Central

Lorenz, Matthias W.; Bickel, Horst; Bots, Michiel L.; Breteler, Monique M.B.; Catapano, Alberico L.; Desvarieux, Moise; Hedblad, Bo; Iglseder, Bernhard; Johnsen, Stein Harald; Juraska, Michal; Kiechl, Stefan; Mathiesen, Ellisiv B.; Norata, Giuseppe D.; Grigore, Liliana; Polak, Joseph; Poppert, Holger; Rosvall, Maria; Rundek, Tatjana; Sacco, Ralph L.; Sander, Dirk; Sitzer, Matthias; Steinmetz, Helmuth; Stensland, Eva; Willeit, Johann; Witteman, Jacqueline; Yanez, David; Thompson, Simon G.

2013-01-01

Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. PMID:20435179

Comparative Effect of Orthosis Design on Functional Performance

DTIC Science & Technology

2012-03-21

progresses forward from mid to terminal stance. This also allows forefoot loading during agility and running activities. The modular design allows...patient to adopt a midfoot strike , as the combination of a heel strike with the plantar flexed foot plate leads to knee hyperextension. On average

FROM COAST TO OFFSHORE: SOME PROGRESS ON DEVELOPING MULTI-RESOURCE DESIGNS FOR GREAT LAKES MONITORING

EPA Science Inventory

In the next generation of monitoring the condition of very large aquatic systems, we need to explore designs that integrate across multiple aquatic resource types, including coastal subsystems, nearshore, and offshore components, which together make up the total hydroscape. This ...

Progress in cybernetics and systems research. Vol. XI. Data base design. International Information Systems. Semiotic Systems. Artificial Intelligence. Cybernetics and Philosophy. Special aspects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trappl, R.; Findler, N.V.; Horn, W.

1982-01-01

This book covers current research topics in six areas. These are data base design, international information systems, semiotic systems, artificial intelligence, cybernetics and philosophy, and special aspects of systems research. 1326 references.

[Research progress of mammalian synthetic biology in biomedical field].

PubMed

Yang, Linfeng; Yin, Jianli; Wang, Meiyan; Ye, Haifeng

2017-03-25

Although still in its infant stage, synthetic biology has achieved remarkable development and progress during the past decade. Synthetic biology applies engineering principles to design and construct gene circuits uploaded into living cells or organisms to perform novel or improved functions, and it has been widely used in many fields. In this review, we describe the recent advances of mammalian synthetic biology for the treatment of diseases. We introduce common tools and design principles of synthetic gene circuits, and then we demonstrate open-loop gene circuits induced by different trigger molecules used in disease diagnosis and close-loop gene circuits used for biomedical applications. Finally, we discuss the perspectives and potential challenges of synthetic biology for clinical applications.

Universality of accelerating change

NASA Astrophysics Data System (ADS)

Eliazar, Iddo; Shlesinger, Michael F.

2018-03-01

On large time scales the progress of human technology follows an exponential growth trend that is termed accelerating change. The exponential growth trend is commonly considered to be the amalgamated effect of consecutive technology revolutions - where the progress carried in by each technology revolution follows an S-curve, and where the aging of each technology revolution drives humanity to push for the next technology revolution. Thus, as a collective, mankind is the 'intelligent designer' of accelerating change. In this paper we establish that the exponential growth trend - and only this trend - emerges universally, on large time scales, from systems that combine together two elements: randomness and amalgamation. Hence, the universal generation of accelerating change can be attained by systems with no 'intelligent designer'.

High-dose neutron detector project update

DOE Office of Scientific and Technical Information (OSTI.GOV)

Menlove, Howard Olsen; Henzlova, Daniela

These are the slides for a progress review meeting by the sponsor. This is an update on the high-dose neutron detector project. In summary, improvements in both boron coating and signal amplification have been achieved; improved boron coating materials and procedures have increased efficiency by ~ 30-40% without the corresponding increase in the detector plate area; low dead-time via thin cell design (~ 4 mm gas gaps) and fast amplifiers; prototype PDT 8” pod has been received and testing is in progress; significant improvements in efficiency and stability have been verified; use commercial PDT 10B design and fabrication to obtainmore » a faster path from the research to practical high-dose neutron detector.« less

Rocket Propulsion 21 Steering Committee Meeting (RP21) NASA In-Space Propulsion Update

NASA Technical Reports Server (NTRS)

Klem, Mark

2015-01-01

In-house Support of NEXT-C Contract Status Thruster NEXT Long Duration Test post-test destructive evaluation in progress Findings will be used to verify service life models identify potential design improvements Cathode heater fabrication initiated for cyclic life testing Thruster operating algorithm definition verification initiated to provide operating procedures for mission users High voltage propellant isolator life test voluntarily terminated after successfully operating 51,200 h Power processor unit (PPU) Replaced all problematic stacked multilayer ceramic dual inline pin capacitors within PPU Test bed Rebuilt installed discharge power supply primary power board Completed full functional performance characterization Final test report in progress Transferred PPU Testbed to contractor to support prototype design effort.

Nanoscale perspective: Materials designs and understandings in lithium metal anodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Dingchang; Liu, Yayuan; Pei, Allen

Li metal chemistry is a promising alternative with a much higher energy density than that of state-of-the-art Li-ion counterparts. However, significant challenges including safety issues and poor cyclability have severely impeded Li metal technology from becoming viable. In recent years, nanotechnologies have become increasingly important in materials design and fabrication for Li metal anodes, contributing to major progress in the field. In this review, we first introduce the main achievements in Li metal battery systems fulfilled by nanotechnologies, particularly regarding Li metal anode design and protection, ultrastrong separator engineering, safety monitoring, and smart functions. Next, we introduce recent studies onmore » nanoscale Li nucleation/deposition. Lastly, we discuss possible future research directions. We hope this review delivers an overall picture of the role of nanoscale approaches in the recent progress of Li metal battery technology and inspires more research in the future.« less

Nanoscale perspective: Materials designs and understandings in lithium metal anodes

DOE PAGES

Lin, Dingchang; Liu, Yayuan; Pei, Allen; ...

2017-05-19

Li metal chemistry is a promising alternative with a much higher energy density than that of state-of-the-art Li-ion counterparts. However, significant challenges including safety issues and poor cyclability have severely impeded Li metal technology from becoming viable. In recent years, nanotechnologies have become increasingly important in materials design and fabrication for Li metal anodes, contributing to major progress in the field. In this review, we first introduce the main achievements in Li metal battery systems fulfilled by nanotechnologies, particularly regarding Li metal anode design and protection, ultrastrong separator engineering, safety monitoring, and smart functions. Next, we introduce recent studies onmore » nanoscale Li nucleation/deposition. Lastly, we discuss possible future research directions. We hope this review delivers an overall picture of the role of nanoscale approaches in the recent progress of Li metal battery technology and inspires more research in the future.« less

Does monitoring goal progress promote goal attainment? A meta-analysis of the experimental evidence.

PubMed

Harkin, Benjamin; Webb, Thomas L; Chang, Betty P I; Prestwich, Andrew; Conner, Mark; Kellar, Ian; Benn, Yael; Sheeran, Paschal

2016-02-01

Control theory and other frameworks for understanding self-regulation suggest that monitoring goal progress is a crucial process that intervenes between setting and attaining a goal, and helps to ensure that goals are translated into action. However, the impact of progress monitoring interventions on rates of behavioral performance and goal attainment has yet to be quantified. A systematic literature search identified 138 studies (N = 19,951) that randomly allocated participants to an intervention designed to promote monitoring of goal progress versus a control condition. All studies reported the effects of the treatment on (a) the frequency of progress monitoring and (b) subsequent goal attainment. A random effects model revealed that, on average, interventions were successful at increasing the frequency of monitoring goal progress (d+ = 1.98, 95% CI [1.71, 2.24]) and promoted goal attainment (d+ = 0.40, 95% CI [0.32, 0.48]). Furthermore, changes in the frequency of progress monitoring mediated the effect of the interventions on goal attainment. Moderation tests revealed that progress monitoring had larger effects on goal attainment when the outcomes were reported or made public, and when the information was physically recorded. Taken together, the findings suggest that monitoring goal progress is an effective self-regulation strategy, and that interventions that increase the frequency of progress monitoring are likely to promote behavior change. (c) 2016 APA, all rights reserved).

Determination of lactic acid level in systemic liquids in children with progressive encephalopathies.

PubMed

Marszał, Elzbieta; Wojaczyńska-Stanek, Katarzyna; Pietruszewski, Jerzy; Emich-Widera, Ewa; Bielińska-Bujniewicz, Eugenia

2002-03-01

This article reports the results of research into the activities of lactic acid concentrations in the body fluids of children with progressive encephalopathies (PE) in comparison to patients with non-progressive encephalopathies (NPE) and those with non-progressive encephalopathies with concomitant epilepsy (NPEE). The study was designed to determine whether there is difference between the serum and CSF lactic acid concentrations in children with progressive encephalopathies (PE), static (non-progressive) encephalopathies (NPE) and non progressive encephalopathies with concomitant epilepsy (NPEE), and whether the clinical status correlates with the concentration of these biochemical markers in children with PE. The assessment involved 138 children of both sexes, whose age ranged between 8 months and 15 years, diagnosed and treated in the Neurology Department at the Pediatric Clinic of the Silesian Medical Academy in Katowice between 1995 and 1997. Lactate concentrations were determined in serum and cerebro-spinal fluid and analyzed statistically. The findings showed higher serum and CSF concentrations in children with PE than in patients who manifested non-progressive forms of encephalopathy. The degree of clinical symptom aggravation in PE children was likewise analyzed and compared to the values of lactate concentrations in body fluids; however, no correlation was found between these parameters. Children with progressive encephalopathies present higher lactate concentrations in serum and cerebrospinal fluid than patients with static (non-progressive) encephalopathy.

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

PubMed Central

2011-01-01

Background No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis (MS). The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) trial tests the safety and feasibility of treatment with a candidate cell-based therapy, and will inform the wider challenge of designing early phase clinical trials to evaluate putative neuroprotective therapies in progressive MS. Illustrated by the MSCIMS trial protocol, we describe a novel methodology based on detailed assessment of the anterior visual pathway as a model of wider disease processes - the "sentinel lesion approach". Methods/design MSCIMS is a phase IIA study of autologous mesenchymal stem cells (MSCs) in secondary progressive MS. A pre-test : post-test design is used with healthy controls providing normative data for inter-session variability. Complementary eligibility criteria and outcomes are used to select participants with disease affecting the anterior visual pathway. Results Ten participants with MS and eight healthy controls were recruited between October 2008 and March 2009. Mesenchymal stem cells were successfully isolated, expanded and characterised in vitro for all participants in the treatment arm. Conclusions In addition to determining the safety and feasibility of the intervention and informing design of future studies to address efficacy, MSCIMS adopts a novel strategy for testing neuroprotective agents in MS - the sentinel lesion approach - serving as proof of principle for its future wider applicability. Trial registration ClinicalTrials.gov (NCT00395200). PMID:21366911

An acoustic charge transport imager for high definition television applications

NASA Technical Reports Server (NTRS)

Hunt, W. D.; Brennan, Kevin F.

1994-01-01

The primary goal of this research is to develop a solid-state high definition television (HDTV) imager chip operating at a frame rate of about 170 frames/sec at 2 Megapixels per frame. This imager offers an order of magnitude improvement in speed over CCD designs and will allow for monolithic imagers operating from the IR to the UV. The technical approach of the project focuses on the development of the three basic components of the imager and their integration. The imager chip can be divided into three distinct components: (1) image capture via an array of avalanche photodiodes (APD's), (2) charge collection, storage and overflow control via a charge transfer transistor device (CTD), and (3) charge readout via an array of acoustic charge transport (ACT) channels. The use of APD's allows for front end gain at low noise and low operating voltages while the ACT readout enables concomitant high speed and high charge transfer efficiency. Currently work is progressing towards the development of manufacturable designs for each of these component devices. In addition to the development of each of the three distinct components, work towards their integration is also progressing. The component designs are considered not only to meet individual specifications but to provide overall system level performance suitable for HDTV operation upon integration. The ultimate manufacturability and reliability of the chip constrains the design as well. The progress made during this period is described in detail in Sections 2-4.

Progressive Precision Surface Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duchaineau, M; Joy, KJ

2002-01-11

We introduce a novel wavelet decomposition algorithm that makes a number of powerful new surface design operations practical. Wavelets, and hierarchical representations generally, have held promise to facilitate a variety of design tasks in a unified way by approximating results very precisely, thus avoiding a proliferation of undergirding mathematical representations. However, traditional wavelet decomposition is defined from fine to coarse resolution, thus limiting its efficiency for highly precise surface manipulation when attempting to create new non-local editing methods. Our key contribution is the progressive wavelet decomposition algorithm, a general-purpose coarse-to-fine method for hierarchical fitting, based in this paper on anmore » underlying multiresolution representation called dyadic splines. The algorithm requests input via a generic interval query mechanism, allowing a wide variety of non-local operations to be quickly implemented. The algorithm performs work proportionate to the tiny compressed output size, rather than to some arbitrarily high resolution that would otherwise be required, thus increasing performance by several orders of magnitude. We describe several design operations that are made tractable because of the progressive decomposition. Free-form pasting is a generalization of the traditional control-mesh edit, but for which the shape of the change is completely general and where the shape can be placed using a free-form deformation within the surface domain. Smoothing and roughening operations are enhanced so that an arbitrary loop in the domain specifies the area of effect. Finally, the sculpting effect of moving a tool shape along a path is simulated.« less

Single Case Design Elements in Text Comprehension Research for Students with Developmental Disabilities

ERIC Educational Resources Information Center

Snyder, Sara M.; Knight, Victoria F.; Ayres, Kevin M.; Mims, Pamela J.; Sartini, Emily C.

2017-01-01

Recently researchers have begun exploring the efficacy of interventions designed to improve text comprehension skills for students with developmental disabilities (DD). Text comprehension is essential for understanding academic content as students with disabilities make progress in the general education curriculum. This article focuses on single…

Designing a Decision-Support System for Enrollment Management. AIR 1985 Annual Forum Paper.

ERIC Educational Resources Information Center

Glover, Robert H.

University of Hartford's decision-support system for enrollment management, which uses fourth-generation software tools, is described, with attention to the conceptual framework, design and implementation plan, and progress to date. The university's planners, institutional researchers, and admissions and financial aid officers are cooperating in…

Soundstop. An Experimental Student Housing Study.

ERIC Educational Resources Information Center

Ontario Dept. of Education, Toronto. School Planning and Building Research Section.

The design development of a housing facility for deaf and blind students is reviewed in considerable detail. Initially traditional architectural solutions to the creation of dormitory space and accompanying circulation patterns are examined for their effect upon the lives of the inhabitants. The subsequent design progression which is presented is…

Children's Services Statistical Neighbour Benchmarking Tool. Practitioner User Guide

ERIC Educational Resources Information Center

National Foundation for Educational Research, 2007

2007-01-01

Statistical neighbour models provide one method for benchmarking progress. For each local authority (LA), these models designate a number of other LAs deemed to have similar characteristics. These designated LAs are known as statistical neighbours. Any LA may compare its performance (as measured by various indicators) against its statistical…

Progress in aircraft design since 1903

NASA Technical Reports Server (NTRS)

1974-01-01

Significant developments in aviation history are documented to show the advancements in aircraft design which have taken place since 1903. Each aircraft is identified according to the manufacturer, powerplant, dimensions, normal weight, and typical performance. A narrative summary of the major accomplishments of the aircraft is provided. Photographs of each aircraft are included.

Pavement design and performance studies : progress report no. 4 on phase A, performance study of typical Virginia pavements.

DOT National Transportation Integrated Search

1970-01-01

The performance of in-service typical Virginia flexible and rigid pavements in all areas of the state is under evaluation. The objectives are to provide a ready reference for designers and field engineers and to provide background information for des...

Design, fabrication and test of prototype furnace for continuous growth of wide silicon ribbon

NASA Technical Reports Server (NTRS)

Duncan, C. S.; Seidensticker, R. G.

1975-01-01

Progress is reported during the apparatus design, fabrication, and assembly phases of a program to grow wide, thin silicon dendritic web. The growth facility was essentially completed with any significant problems arising. A complete set of detailed fabrication drawings is included as an appendix.

AN EARLY SCHOOL ADMISSION PORJECT. PROGRESS REPORT 1962-1963.

ERIC Educational Resources Information Center

Baltimore City Public Schools, MD.

"PROJECT HELP" REPRESENTS AN EDUCATIONAL PROGRAM DESIGNED TO ENRICH THE LIVES OR 4- AND 5-YEAR-OLD CULTURALLY DEPRIVED CHILDREN. IT IS A RESEARCH PROJECT DESIGNED TO DISCOVER WAYS TO ACCELERATE THE ACHIEVEMENT OF CHILDREN LIMITED IN THEIR DEVELOPMENT BY ENVIRONMENTAL FACTORS BEYOND THEIR CONTROL, TO INCREASE PARENTAL UNDERSTANDING AND…

Recent progress on the development of anisotropic gold nanoparticles: Design strategies and growth mechanism.

PubMed

Jones, Stacy; Pramanik, Avijit; Sweet, Carrie; Keyes, Anthony; Begum, Salma; Vangra, Aruna; Yu, Hongtal; Fu, Peter P; Ray, Paresh Chandra

2017-01-02

This review summarizes recent advances on design strategies for shape-controlled anisotropic gold nanoparticles. Detailed chemical mechanism has been discussed to understand the anisotropic growth. The effect of various chemical parameters and surface facets for the formation of different shaped anisotropic nanoparticles have been addressed.

75 FR 57029 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... major initiative designed to: (1) Prevent the onset and reduce the progression of substance abuse... IV evaluation have necessitated some streamlining of the original evaluation design. Since the... implementation and change in the NOMs. Information for both surveys will be gathered by the grantees' evaluators...

Intelligent Tutors in Immersive Virtual Environments

ERIC Educational Resources Information Center

Yan, Peng; Slator, Brian M.; Vender, Bradley; Jin, Wei; Kariluoma, Matti; Borchert, Otto; Hokanson, Guy; Aggarwal, Vaibhav; Cosmano, Bob; Cox, Kathleen T.; Pilch, André; Marry, Andrew

2013-01-01

Research into virtual role-based learning has progressed over the past decade. Modern issues include gauging the difficulty of designing a goal system capable of meeting the requirements of students with different knowledge levels, and the reasonability and possibility of taking advantage of the well-designed formula and techniques served in other…

Iterative Exploration, Design and Evaluation of Support for Query Reformulation in Interactive Information Retrieval.

ERIC Educational Resources Information Center

Belkin, N. J.; Cool, C.; Kelly, D.; Lin, S. -J.; Park, S. Y.; Perez-Carballo, J.; Sikora, C.

2001-01-01

Reports on the progressive investigation of techniques for supporting interactive query reformulation in the TREC (Text Retrieval Conference) Interactive Track. Highlights include methods of term suggestion; interface design to support different system functionalities; an overview of each year's TREC investigation; and relevance to the development…

Educational Design Research: Signs of Progress

ERIC Educational Resources Information Center

Reeves, Thomas C.

2015-01-01

This special issue of the "Australasian Journal of Educational Technology" includes an introductory article by the guest editors and six papers that illustrate the potential of educational design research (EDR) to address important problems in higher education. In this final paper, reflections on the papers are made. Then the rationale…

Research on Curricular Development for Pre-Kindergarten Mathematics and Science

ERIC Educational Resources Information Center

Kinzie, Mable B.; Whittaker, Jessica Vick; McGuire, Pat; Lee, Youngju; Kilday, Carolyn

2015-01-01

Background/Context: As increasing attention is paid to preparing students to succeed in school, the development and adoption of research-based curricula have become progressively more important. However, many curricular designs lack a basis in scientific evidence; research and curricular design are frequently treated as two separate enterprises.…

Progress on the FabrIc for Frontier Experiments project at Fermilab

DOE PAGES

Box, Dennis; Boyd, Joseph; Dykstra, Dave; ...

2015-12-23

The FabrIc for Frontier Experiments (FIFE) project is an ambitious, major-impact initiative within the Fermilab Scientific Computing Division designed to lead the computing model for Fermilab experiments. FIFE is a collaborative effort between experimenters and computing professionals to design and develop integrated computing models for experiments of varying needs and infrastructure. The major focus of the FIFE project is the development, deployment, and integration of Open Science Grid solutions for high throughput computing, data management, database access and collaboration within experiment. To accomplish this goal, FIFE has developed workflows that utilize Open Science Grid sites along with dedicated and commercialmore » cloud resources. The FIFE project has made significant progress integrating into experiment computing operations several services including new job submission services, software and reference data distribution through CVMFS repositories, flexible data transfer client, and access to opportunistic resources on the Open Science Grid. Hence, the progress with current experiments and plans for expansion with additional projects will be discussed. FIFE has taken a leading role in the definition of the computing model for Fermilab experiments, aided in the design of computing for experiments beyond Fermilab, and will continue to define the future direction of high throughput computing for future physics experiments worldwide« less

Multi-Scale Hierarchical and Topological Design of Structures for Failure Resistance

DTIC Science & Technology

2013-10-04

materials, simulation, 3D printing , advanced manufacturing, design, fracture Markus J. Buehler Massachusetts Institute of Technology (MIT) 77...by Mineralized Natural Materials: Computation, 3D printing , and Testing, Advanced Functional Materials, (09 2013): 0. doi: 10.1002/adfm.201300215 10...have made substantial progress. Recent work focuses on the analysis of topological effects of composite design, 3D printing of bioinspired and

Developing Exemplar Interactive Multimedia Instruction for Unmanned Aircraft System Repairers

DTIC Science & Technology

2017-08-01

material and also compared the effectiveness of two different IMI design approaches used to progress the learner through the various training modules...instruction. For the Hydraulics Theory and Components, we compared the learner-controlled Interactive Multimedia Instruction and the designer ... Design Three UAS Repairer IMI modules were developed, and the effectiveness of each was compared to the current live instruction covering the

Interactional Patterns Among Dental School Students and the Influence of Building Design. Final Progress Report on the Planning Study: Behavioral Factors in Dental School Design.

ERIC Educational Resources Information Center

Myrick, Richard; Marx, Barbara S.

The relationship of architecture to human behavior is a topic of increasing concern both to designers and behavioral scientists. To further evaluate the extent of the relationship a series of preliminary investigations has been undertaken. The primary means of measurement was informal conversations of dental students as related to the…

Curriculum Design and Management in the Digital Media U: Applying the Corporate University Concept to a Business Sub-Sector

ERIC Educational Resources Information Center

Selby, Les; Russell, David

2005-01-01

Purpose: To report on the progress of Digital Media U, a tailor-made portal, learning environment and management system. Design/methodology/approach: Discusses the design of the learning content domains, acquisition of the content and the systems for managing the curriculum in the future, including the application of a new model of accreditation.…

Basic Remote Sensing Investigations for Beach Reconnaissance.

DTIC Science & Technology

Progress is reported on three tasks designed to develop remote sensing beach reconnaissance techniques applicable to the benthic, beach intertidal...and beach upland zones. Task 1 is designed to develop remote sensing indicators of important beach composition and physical parameters which will...ultimately prove useful in models to predict beach conditions. Task 2 is designed to develop remote sensing techniques for survey of bottom features in

Design of combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor for treatment of diabetic nephropathy (VA NEPHRON-D).

PubMed

Fried, Linda F; Duckworth, William; Zhang, Jane Hongyuan; O'Connor, Theresa; Brophy, Mary; Emanuele, Nicholas; Huang, Grant D; McCullough, Peter A; Palevsky, Paul M; Seliger, Stephen; Warren, Stuart R; Peduzzi, Peter

2009-02-01

Both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) can slow the progression of diabetic nephropathy. Even with ACEI or ARB treatment, the proportion of patients who progress to end-stage renal disease (ESRD) remains high. Interventions that achieve more complete blockade of the renin-angiotensin system, such as combination ACEI and ARB, might be beneficial. This approach may decrease progression of nondiabetic kidney disease. In diabetic nephropathy, combination therapy decreases proteinuria, but its effect in slowing progression is unknown. In addition, the potential for hyperkalemia may limit the utility of combined therapy in this population. VA NEPHRON-D is a randomized, double-blind, multicenter clinical trial to assess the effect of combination losartan and lisinopril, compared with losartan alone, on the progression of kidney disease in 1850 patients with diabetes and overt proteinuria. The primary endpoints are time to (1) reduction in estimated GFR (eGFR) of > 50% (if baseline < 60 ml/min/1.73 m(2)); (2) reduction in eGFR of 30 ml/min/1.73 m(2) (if baseline > or = 60 ml/min/1.73 m(2)); (3) progression to ESRD (need for dialysis, renal transplant, or eGFR < 15 ml/min/1.73 m(2)); or (4) death. The secondary endpoint is time to change in eGFR or ESRD. Tertiary endpoints are cardiovascular events, slope of change in eGFR, and change in albuminuria at 1 yr. Specific safety endpoints are serious hyperkalemia (potassium > 6 mEq/L, requiring admission, emergency room visit, or dialysis), all-cause mortality, and other serious adverse events. This paper discusses the design and key methodological issues that arose during the planning of the study.

Sensitivity of measuring the progress in financial risk protection to survey design and its socioeconomic and demographic determinants: A case study in Rwanda.

PubMed

Lu, Chunling; Liu, Kai; Li, Lingling; Yang, Yuhong

2017-04-01

Reliable and comparable information on households with catastrophic health expenditure (HCHE) is crucial for monitoring and evaluating our progress towards achieving universal financial risk protection. This study aims to investigate the sensitivity of measuring the progress in financial risk protection to survey design and its socioeconomic and demographic determinants. Using the Rwanda Integrated Living Conditions Survey in 2005 and 2010/2011, we derived the level and trend of the percentage of the HCHE using out-of-pocket health spending data derived from (1) a health module with a two-week recall period and six (2005)/seven (2010/2011) survey questions (Method 1) and (2) a consumption module with a four-week/ten-/12-month recall period and 11(2005)/24 (2010/2011) questions (Method 2). Using multilevel logistic regression analysis, we investigated the household socioeconomic and demographic characteristics that affected the sensitivity of estimating the HCHE to survey design. We found that Method 1 generated a significantly higher HCHE estimate (9.2%, 95% confidence interval 8.4%-10.0%) than Method2 (7.4%, 6.6%-8.1%) in 2005 and lower estimate (5.6%, 5.2%-6.1%) than Method 2 (8.2%, 7.6%-8.7%) in 2010/2011. The estimated trends of the HCHE using the two methods were not consistent between the two years. A household's size, its income quintile, having no under-five children, and educational level of its head were positively associated with the consistency of its HCHE status when using the two survey methods. Estimates of the progress in financial risk protection, especially among the most vulnerable households, are sensitive to survey design. These results are robust to various thresholds of catastrophic health spending. Future work must focus on mitigating survey effects through the development of statistical tools. Copyright © 2017 Elsevier Ltd. All rights reserved.

Sensitivity of measuring the progress in financial risk protection to survey design and its socioeconomic and demographic determinants: A case study in Rwanda

PubMed Central

Lu, Chunling; Liu, Kai; Li, Lingling; Yang, Yuhong

2017-01-01

Reliable and comparable information on households with catastrophic health expenditure (HCHE) is crucial for monitoring and evaluating our progress towards achieving universal financial risk protection. This study aims to investigate the sensitivity of measuring the progress in financial risk protection to survey design and its socioeconomic and demographic determinants. Using the Rwanda Integrated Living Conditions Survey in 2005 and 2010/2011, we derived the level and trend of the percentage of the HCHE using out-of-pocket health spending data derived from (1) a health module with a two-week recall period and six (2005)/seven (2010/2011) survey questions (Method 1) and (2) a consumption module with a four-week/ten-/12-month recall period and 11(2005)/24 (2010/2011) questions (Method 2). Using multilevel logistic regression analysis, we investigated the household socioeconomic and demographic characteristics that affected the sensitivity of estimating the HCHE to survey design. We found that Method 1 generated a significantly higher HCHE estimate (9.2%, 95% confidence interval 8.4%–10.0%) than Method2 (7.4%, 6.6%–8.1%) in 2005 and lower estimate (5.6%, 5.2%–6.1%) than Method 2 (8.2%, 7.6% –8.7%) in 2010/2011. The estimated trends of the HCHE using the two methods were not consistent between the two years. A household's size, its income quintile, having no under-five children, and educational level of its head were positively associated with the consistency of its HCHE status when using the two survey methods. Estimates of the progress in financial risk protection, especially among the most vulnerable households, are sensitive to survey design. These results are robust to various thresholds of catastrophic health spending. Future work must focus on mitigating survey effects through the development of statistical tools. PMID:28189819

Toleration and the Design of Norms.

PubMed

Floridi, Luciano

2015-10-01

One of the pressing challenges we face today-in a post-Westphalian order (emergence of the state as the modern, political information agent) and post-Bretton Woods world (emergence of non-state multiagent systems or MASs as "hyperhistorical" players in the global economy and politics)-is how to design the right kind of MAS that can take full advantage of the socio-economic and political progress made so far, while dealing successfully with the new global challenges that are undermining the best legacy of that very progress. This is the topic of the article. In it, I argue that (i) in order to design the right kind of MAS, we need to design the right kind of norms that constitute them; (ii) in order to design the right kind of constitutive norms, we need to identify and adopt the right kind of principles of normative design; (iii) toleration is one of those principles; (iv) unfortunately, its role as a foundation for the design of norms has been undermined by the "paradox of toleration"; (v) however, the paradox can be solved; (vi) so toleration can be re-instated as the right kind of foundational principle for the design of the right kind of norms that can constitute the right kind of MAS that can operate across cultures, societies and states, to help us to tackle the new global challenges facing us.

NAEP 1996 Science Report for Department of Defense Dependents Schools. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Department of Defense Dependents Schools, Grade 4. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

Ballator, Nada; O'Sullivan, Christine Y.; Jerry, Laura

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

Continuation of a Postdoctoral Research Associateship Program

DTIC Science & Technology

1998-12-01

ODRS and LPO can be alleviated by nitric oxide. Rsearch in Progress: The experimental part of the research has been completed. The experimental ... Rsearch in Progress: The experimental part of the research has been completed. The experimental results have been published, or prepared for...construed as an official Department of the Army position, policy or decision unless so designated by other documentation. •*•*«, 19990521 029 fPII

A Bayesian Hierarchical Model for Large-Scale Educational Surveys: An Application to the National Assessment of Educational Progress. Research Report. ETS RR-04-38

ERIC Educational Resources Information Center

Johnson, Matthew S.; Jenkins, Frank

2005-01-01

Large-scale educational assessments such as the National Assessment of Educational Progress (NAEP) sample examinees to whom an exam will be administered. In most situations the sampling design is not a simple random sample and must be accounted for in the estimating model. After reviewing the current operational estimation procedure for NAEP, this…

Real-time fMRI neurofeedback: Progress and challenges

PubMed Central

Sulzer, J.; Haller, S.; Scharnowski, F.; Weiskopf, N.; Birbaumer, N.; Blefari, M.L.; Bruehl, A.B.; Cohen, L.G.; deCharms, R.C.; Gassert, R.; Goebel, R.; Herwig, U.; LaConte, S.; Linden, D.; Luft, A.; Seifritz, E.; Sitaram, R.

2016-01-01

In February of 2012, the first international conference on real time functional magnetic resonance imaging (rtfMRI) neurofeedback was held at the Swiss Federal Institute of Technology Zurich (ETHZ), Switzerland. This review summarizes progress in the field, introduces current debates, elucidates open questions, and offers viewpoints derived from the conference. The review offers perspectives on study design, scientific and clinical applications, rtfMRI learning mechanisms and future outlook. PMID:23541800

Total RNA Sequencing Analysis of DCIS Progressing to Invasive Breast Cancer

DTIC Science & Technology

2017-09-01

Public Release; Distribution Unlimited The views , opinions and/or findings contained in this report are those of the author(s) and should not be...STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT: This project is designed to complement a multi ...fact progress to invasive disease (IBC), and complements our multi -institutional, NIH-funded study of genetic and epigenetic alterations of pre

Test bed design for evaluating the Space Station ECLSS Water Recovery System

NASA Technical Reports Server (NTRS)

Ezell, Timothy G.; Long, David A.

1990-01-01

The design of the Phase III Environmental Control and Life Support System (ECLSS) Water Recovery System (WRS) test bed is in progress at the Marshall Space Flight Center (MSFC), building 4755, in Huntsville, Alabama. The overall design for the ECLSS WRS test bed will be discussed. Described within this paper are the design, fabrication, placement, and testing of the supporting facility which will provide the test bed for the ECLSS subsystems. Topics to be included are sterilization system design, component selection, microbial design considerations, and verification of test bed design prior to initiating WRS testing.

Integration of rocket turbine design and analysis through computer graphics

NASA Technical Reports Server (NTRS)

Hsu, Wayne; Boynton, Jim

1988-01-01

An interactive approach with engineering computer graphics is used to integrate the design and analysis processes of a rocket engine turbine into a progressive and iterative design procedure. The processes are interconnected through pre- and postprocessors. The graphics are used to generate the blade profiles, their stacking, finite element generation, and analysis presentation through color graphics. Steps of the design process discussed include pitch-line design, axisymmetric hub-to-tip meridional design, and quasi-three-dimensional analysis. The viscous two- and three-dimensional analysis codes are executed after acceptable designs are achieved and estimates of initial losses are confirmed.

NASA's Space Launch System: Development and Progress

NASA Technical Reports Server (NTRS)

Honeycutt, John; Lyles, Garry

2016-01-01

NASA is embarked on a new era of space exploration that will lead to new capabilities, new destinations, and new discoveries by both human and robotic explorers. Today, the International Space Station (ISS), supported by NASA's commercial partners, and robotic probes, are yielding knowledge that will help make this exploration possible. NASA is developing both the Orion crew vehicle and the Space Launch System (SLS) that will carry out a series of increasingly challenging missions that will eventually lead to human exploration of Mars. This paper will discuss the development and progress on the SLS. The SLS architecture was designed to be safe, affordable, and sustainable. The current configuration is the result of literally thousands of trade studies involving cost, performance, mission requirements, and other metrics. The initial configuration of SLS, designated Block 1, will launch a minimum of 70 metric tons (t) into low Earth orbit - significantly greater capability than any current launch vehicle. It is designed to evolve to a capability of 130 t through the use of upgraded main engines, advanced boosters, and a new upper stage. With more payload mass and volume capability than any rocket in history, SLS offers mission planners larger payloads, faster trip times, simpler design, shorter design cycles, and greater opportunity for mission success. Since the program was officially created in fall 2011, it has made significant progress toward first launch readiness of the Block 1 vehicle in 2018. Every major element of SLS continued to make significant progress in 2015. The Boosters element fired Qualification Motor 1 (QM-1) in March 2015, to test the 5-segment motor, including new insulation, joint, and propellant grain designs. The Stages element marked the completion of more than 70 major components of test article and flight core stage tanks. The Liquid Engines element conducted seven test firings of an RS-25 engine under SLS conditions. The Spacecraft/Payload Integration and Evolution element marked completion of the upper stage test article. Major work continues in 2016 as the program continues both flight and development RS-25 engine testing, begins welding test article and flight core stage tanks, completes stage adapter manufacturing, and test fires the second booster qualification motor. This paper will discuss the program's key accomplishments to date and the challenging work ahead for what will be the world's most capable launch vehicle.

NASA's SPACE LAUNCH SYSTEM: Development and Progress

NASA Technical Reports Server (NTRS)

Honeycutt, John; Lyles, Garry

2016-01-01

NASA is embarked on a new era of space exploration that will lead to new capabilities, new destinations, and new discoveries by both human and robotic explorers. Today, the International Space Station (ISS) and robotic probes are yielding knowledge that will help make this exploration possible. NASA is developing both the Orion crew vehicle and the Space Launch System (SLS) (Figure 1), that will carry out a series of increasingly challenging missions leading to human exploration of Mars. This paper will discuss the development and progress on the SLS. The SLS architecture was designed to be safe, affordable, and sustainable. The current configuration is the result of literally thousands of trade studies involving cost, performance, mission requirements, and other metrics. The initial configuration of SLS, designated Block 1, will launch a minimum of 70 metric tons (mT) (154,324 pounds) into low Earth orbit - significantly greater capability than any current launch vehicle. It is designed to evolve to a capability of 130 mT (286,601 pounds) through the use of upgraded main engines, advanced boosters, and a new upper stage. With more payload mass and volume capability than any existing rocket, SLS offers mission planners larger payloads, faster trip times, simpler design, shorter design cycles, and greater opportunity for mission success. Since the program was officially created in fall 2011, it has made significant progress toward launch readiness in 2018. Every major element of SLS continued to make significant progress in 2015. Engineers fired Qualification Motor 1 (QM-1) in March 2015 to test the 5-segment motor, including new insulation, joint, and propellant grain designs. More than 70 major components of test article and flight hardware for the Core Stage have been manufactured. Seven test firings have been completed with an RS-25 engine under SLS operating conditions. The test article for the Interim Cryogenic Propulsion Stage (ICPS) has also been completed. Major work continues in 2016 as the program continues both flight and development RS-25 engine testing, begins welding test article and flight core stage tanks, completes stage adapter manufacturing, and test fires the second booster qualification motor. This paper will discuss the program's key accomplishments to date and the challenging work ahead for what will be the world's most capable launch vehicle.

A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy

PubMed Central

Caciagli, Lorenzo; Bernasconi, Andrea; Wiebe, Samuel; Koepp, Matthias J.; Bernasconi, Neda

2017-01-01

Objective: It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence. Methods: We conducted a systematic review and meta-analysis of MRI studies on progressive atrophy, searching PubMed and Ovid MEDLINE databases for cross-sectional and longitudinal quantitative MRI studies on drug-resistant TLE. Results: We screened 2,976 records and assessed eligibility of 248 full-text articles. Forty-two articles met the inclusion criteria for quantitative evaluation. We observed a predominance of cross-sectional studies, use of different clinical indices of progression, and high heterogeneity in age-control procedures. Meta-analysis of 18/1 cross-sectional/longitudinal studies on hippocampal atrophy (n = 979 patients) yielded a pooled effect size of r = −0.42 for ipsilateral atrophy related to epilepsy duration (95% confidence interval [CI] −0.51 to −0.32; p < 0.0001; I2 = 65.22%) and r = −0.35 related to seizure frequency (95% CI −0.47 to −0.22; p < 0.0001; I2 = 61.97%). Sensitivity analyses did not change the results. Narrative synthesis of 25/3 cross-sectional/longitudinal studies on whole brain atrophy (n = 1,504 patients) indicated that >80% of articles reported duration-related progression in extratemporal cortical and subcortical regions. Detailed analysis of study design features yielded low to moderate levels of evidence for progressive atrophy across studies, mainly due to dominance of cross-sectional over longitudinal investigations, use of diverse measures of seizure estimates, and absence of consistent age control procedures. Conclusions: While the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have employed rather weak designs to directly demonstrate it. Longitudinal multicohort studies are needed to unequivocally differentiate aging from disease progression. PMID:28687722

The HALT Polycystic Kidney Disease Trials: Design and Implementation

PubMed Central

Torres, Vicente E.; Perrone, Ronald D.; Steinman, Theodore I.; Bae, Kyongtae T.; Miller, J. Philip; Miskulin, Dana C.; Oskoui, Frederic Rahbari; Masoumi, Amirali; Hogan, Marie C.; Winklhofer, Franz T.; Braun, William; Thompson, Paul A.; Meyers, Catherine M.; Kelleher, Cass; Schrier, Robert W.

2010-01-01

Background and objectives: Two HALT PKD trials will investigate interventions that potentially slow kidney disease progression in hypertensive autosomal dominant polycystic kidney disease (ADPKD) patients. Studies were designed in early and later stages of ADPKD to assess the impact of intensive blockade of the renin-angiotensin-aldosterone system and level of BP control on progressive renal disease. Design, settings, participants, and measurements: PKD-HALT trials are multicenter, randomized, double-blind, placebo-controlled trials studying 1018 hypertensive ADPKD patients enrolled over 3 yr with 4 to 8 yr of follow-up. In study A, 548 participants, estimated GFR (eGFR) of >60 ml/min per 1.73 m2 were randomized to one of four arms in a 2-by-2 design: combination angiotensin converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) therapy versus ACEi monotherapy at two levels of BP control. In study B, 470 participants, eGFR of 25 to 60 ml/min per 1.73 m2 compared ACEi/ARB therapy versus ACEi monotherapy, with BP control of 120 to 130/70 to 80 mmHg. Primary outcomes of studies A and B are MR-based percent change kidney volume and a composite endpoint of time to 50% reduction of baseline estimated eGFR, ESRD, or death, respectively. Results: This report describes design issues related to (1) novel endpoints such as kidney volume, (2) home versus office BP measures, and (3) the impact of RAAS inhibition on kidney and patient outcomes, safety, and quality of life. Conclusions: HALT PKD will evaluate potential benefits of rigorous BP control and inhibition of the renin-angiotensin-aldosterone system on kidney disease progression in ADPKD. PMID:20089507

From Paper to Production: An Update on NASA's Upper Stage Engine for Exploration

NASA Technical Reports Server (NTRS)

Kynard, Mike

2010-01-01

In 2006, NASA selected an evolved variant of the proven Saturn/Apollo J-2 upper stage engine to power the Ares I crew launch vehicle upper stage and the Ares V cargo launch vehicle Earth departure stage (EDS) for the Constellation Program. Any design changes needed by the new engine would be based where possible on proven hardware from the Space Shuttle, commercial launchers, and other programs. In addition to the thrust and efficiency requirements needed for the Constellation reference missions, it would be an order of magnitude safer than past engines. It required the J-2X government/industry team to develop the highest performance engine of its type in history and develop it for use in two vehicles for two different missions. In the attempt to achieve these goals in the past five years, the Upper Stage Engine team has made significant progress, successfully passing System Requirements Review (SRR), System Design Review (SDR), Preliminary Design Review (PDR), and Critical Design Review (CDR). As of spring 2010, more than 100,000 experimental and development engine parts have been completed or are in various stages of manufacture. Approximately 1,300 of more than 1,600 engine drawings have been released for manufacturing. This progress has been due to a combination of factors: the heritage hardware starting point, advanced computer analysis, and early heritage and development component testing to understand performance, validate computer modeling, and inform design trades. This work will increase the odds of success as engine team prepares for powerpack and development engine hot fire testing in calendar 2011. This paper will provide an overview of the engine development program and progress to date.

Personalized Progressive Addition Lenses: Correlation between Performance and Design.

PubMed

Forkel, Johanne; Reiniger, Jenny Lorén; Muschielok, Adam; Welk, Andrea; Seidemann, Anne; Baumbach, Peter

2017-02-01

A continuous set of personalized designs (design space) for progressive addition lenses (PALs) is investigated. The main goals are (1) to study how the subjects' perception of a personalized design depends on its position in the design space and (2) to compare the performance of personalized PALs to a conventional PAL with a fixed design. In a double-blind study, 51 subjects compared Rodenstock Impression FreeSign 3, which is a family of PALs with a continuously controllable personalized design, and Rodenstock Progressiv Life Free, which is a conventional PAL with a single fixed design. The positions and sizes of viewing zones and the softness of gradients of mean power and astigmatism of personalized lenses were customized to individual viewing preferences. These designs were represented as points in a design space comprising a continuum of PAL designs. Subjective ratings and experimental measurements were used to study viewing zone widths, blur gradient smoothness, amount of distortion, the feeling of safety during motion, and overall wearing comfort. (1) Far viewing zone width (experiments and ratings), near viewing zone width (experiments), blur gradient smoothness, and the amount of distortion (ratings) were significantly dependent on the position of the personalized lens design in the design space. This was consistent with the structure of the design space. (2) 82% of the subjects chose personalized lenses as their favorite. Most subjects reported higher wearing comfort and tolerability with personalized lenses than with conventional lenses. The designs of the tested personalized lenses were perceived by the subjects as intended. This is a prerequisite to the successful customization of PALs to individual wearing preferences. Possible reasons for the preference of the tested personalized lenses are the optimization with respect to individual wearing conditions and the personalization.

[Research progress of articular cartilage scaffold for tissue engineering].

PubMed

Liu, Qingyu; Wang, Fuyou; Yang, Liu

2012-10-01

To review the research progress of articular cartilage scaffold materials and look into the future development prospects. Recent literature about articular cartilage scaffold for tissue engineering was reviewed, and the results from experiments and clinical application about natural and synthetic scaffold materials were analyzed. The design of articular cartilage scaffold for tissue engineering is vital to articular cartilage defects repair. The ideal scaffold can promote the progress of the cartilage repair, but the scaffold materials still have their limitations. It is necessary to pay more attention to the research of the articular cartilage scaffold, which is significant to the repair of cartilage defects in the future.

Evaluation of Progressive Failure Analysis and Modeling of Impact Damage in Composite Pressure Vessels

NASA Technical Reports Server (NTRS)

Sanchez, Christopher M.

2011-01-01

NASA White Sands Test Facility (WSTF) is leading an evaluation effort in advanced destructive and nondestructive testing of composite pressure vessels and structures. WSTF is using progressive finite element analysis methods for test design and for confirmation of composite pressure vessel performance. Using composite finite element analysis models and failure theories tested in the World-Wide Failure Exercise, WSTF is able to estimate the static strength of composite pressure vessels. Additionally, test and evaluation on composites that have been impact damaged is in progress so that models can be developed to estimate damage tolerance and the degradation in static strength.

Connecting the nucleolus to the cell cycle and human disease.

PubMed

Tsai, Robert Y L; Pederson, Thoru

2014-08-01

Long known as the center of ribosome synthesis, the nucleolus is connected to cell cycle regulation in more subtle ways. One is a surveillance system that reacts promptly when rRNA synthesis or processing is impaired, halting cell cycle progression. Conversely, the nucleolus also acts as a first-responder to growth-related stress signals. Here we review emerging concepts on how these "infraribosomal" links between the nucleolus and cell cycle progression operate in both forward and reverse gears. We offer perspectives on how new cancer therapeutic designs that target this infraribosomal mode of cell growth control may shape future clinical progress. © FASEB.

The Correction of Myopia Evaluation Trial: lessons from the study design.

PubMed

Hyman, L; Gwiazda, J

2004-01-01

The Correction of Myopia Evaluation Trial (COMET), a multicentre clinical trial based in 4 schools of optometry in the United States, evaluated the effect of progressive addition lenses versus single vision lenses on myopia progression in an ethnically diverse group of 469 myopic children aged 6 to 11 years. Completion of the clinical trial phase of the study provides an opportunity to evaluate aspects of the study design that contribute to its success. This article describes aspects of the study design that were influential in ensuring the smooth conduct of COMET. These include a dedicated team of investigators, an organisational structure with strong leadership and an independent Co-ordinating Centre, regular communication among investigators, flexible and creative approaches to recruitment and retention, sensitivity to concerns for child safety and child participation, and methods for enhancing and monitoring data reliability. The experience with COMET has provided a number of valuable lessons for all aspects of the study design that should benefit the development and implementation of future clinical trials, particularly those done in similar populations of children. The use of a carefully designed protocol using standard methods by dedicated members of the study team is essential in ensuring achievement of the study aims.

Design and Analysis of Mirror Modules for IXO and Beyond

NASA Technical Reports Server (NTRS)

McClelland, Ryan S.; Powell, Cory; Saha, Timo T.; Zhang, William W.

2011-01-01

Advancements in X-ray astronomy demand thin, light, and closely packed thin optics which lend themselves to segmentation of the annular mirrors and, in turn, a modular approach to the mirror design. The functionality requirements of such a mirror module are well understood. A baseline modular concept for the proposed International X-Ray Observatory (IXO) Flight Mirror Assembly (FMA) consisting of 14,000 glass mirror segments divided into 60 modules was developed and extensively analyzed. Through this development, our understanding of module loads, mirror stress, thermal performance, and gravity distortion have greatly progressed. The latest progress in each of these areas is discussed herein. Gravity distortion during horizontal X-ray testing and on-orbit thermal performance have proved especially difficult design challenges. In light of these challenges, fundamental trades in modular X-ray mirror design have been performed. Future directions in module X-ray mirror design are explored including the development of a 1.8 m diameter FMA utilizing smaller mirror modules. The effect of module size on mirror stress, module self-weight distortion, thermal control, and range of segment sizes required is explored with advantages demonstrated from smaller module size in most cases.

Considering RNAi experimental design in parasitic helminths.

PubMed

Dalzell, Johnathan J; Warnock, Neil D; McVeigh, Paul; Marks, Nikki J; Mousley, Angela; Atkinson, Louise; Maule, Aaron G

2012-04-01

Almost a decade has passed since the first report of RNA interference (RNAi) in a parasitic helminth. Whilst much progress has been made with RNAi informing gene function studies in disparate nematode and flatworm parasites, substantial and seemingly prohibitive difficulties have been encountered in some species, hindering progress. An appraisal of current practices, trends and ideals of RNAi experimental design in parasitic helminths is both timely and necessary for a number of reasons: firstly, the increasing availability of parasitic helminth genome/transcriptome resources means there is a growing need for gene function tools such as RNAi; secondly, fundamental differences and unique challenges exist for parasite species which do not apply to model organisms; thirdly, the inherent variation in experimental design, and reported difficulties with reproducibility undermine confidence. Ideally, RNAi studies of gene function should adopt standardised experimental design to aid reproducibility, interpretation and comparative analyses. Although the huge variations in parasite biology and experimental endpoints make RNAi experimental design standardization difficult or impractical, we must strive to validate RNAi experimentation in helminth parasites. To aid this process we identify multiple approaches to RNAi experimental validation and highlight those which we deem to be critical for gene function studies in helminth parasites.

Genetic progress in homogeneous regions of wheat cultivation in Rio Grande do Sul State, Brazil.

PubMed

Follmann, D N; Cargnelutti Filho, A; Lúcio, A D; de Souza, V Q; Caraffa, M; Wartha, C A

2017-03-30

The State of Rio Grande do Sul (RS) stands out as the largest wheat producer in Brazil. Wheat is the most emphasized winter cereal in RS, attracting public and private investments directed to wheat genetic breeding. The study of genetic progress should be performed routinely at breeding programs to study the behavior of cultivars developed for homogeneous regions of cultivation. The objectives of this study were: 1) to evaluate the genetic progress of wheat grain yield in RS; 2) to evaluate the influence of cultivar competition trial stratification in homogeneous regions of cultivation on the study of genetic progress. Grain yield data of 122 wheat cultivars evaluated in 137 trials arranged in randomized block design with three or four replications were used. Field trials were carried out in 23 locations in RS divided into two homogeneous regions during the period from 2002 to 2013. Genetic progress for RS and homogeneous regions was studied utilizing the method proposed by Vencovsky. Annual genetic progress for wheat grain yield during the period of 12 years in the State of RS was 2.86%, oscillating between homogeneous regions of cultivation. The difference of annual genetic progress in region 1 (1.82%) in relation to region 2 (4.38%) justifies the study of genetic progress by homogeneous regions of cultivation.

Participation in the Cluster Magnetometer Consortium for the Cluster Mission

NASA Technical Reports Server (NTRS)

Kivelson, Margaret

1997-01-01

Prof. M. G. Kivelson (UCLA) and Dr. R. C. Elphic (LANL) are Co-investigators on the Cluster Magnetometer Consortium (CMC) that provided the fluxgate magnetometers and associated mission support for the Cluster Mission. The CMC designated UCLA as the site with primary responsibility for the inter-calibration of data from the four spacecraft and the production of fully corrected data critical to achieving the mission objectives. UCLA was also charged with distributing magnetometer data to the U.S. Co-investigators. UCLA also supported the Technical Management Team, which was responsible for the detailed design of the instrument and its interface. In this final progress report we detail the progress made by the UCLA team in achieving the mission objectives.

RRM3 Fluid Management Device

NASA Technical Reports Server (NTRS)

Barfknecht, P.; Benson, D.; Boyle, R.; DeLee, C.; DiPirro, M.; Francis, J.; Li, X.; McGuire, J.; Mustafi, S.; Tuttle, J.;

Development status of a next generation ECRIS: MARS-D at LBNL

DOE PAGES

Xie, D. Z.; Benitez, J. Y.; Hodgkinson, A.; ...

2015-09-29

To demonstrate a Mixed Axial and Radial field System (MARS) as the best magnet scheme for future ECRISs, MARS-D, a demonstrative ECRIS using a NbTi MARS magnet is progressing at Lawrence Berkeley National Laboratory. An optimized MARS design can use either NbTi or Nb 3Sn coils with reduced engineering complexities to construct the needed high-field magnets. The optimized magnet design could enhance MARS-D to a next generation ECRIS by producing minimum-B field maxima of 5.6 T axially and 3.2 T radially for operating frequencies up to 45 GHz. Lastly, in-progress test winding has achieved a milestone demonstrating the fabrication feasibilitymore » of a MARS closed-loop coil.« less

Development status of a next generation ECRIS: MARS-D at LBNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, D. Z.; Benitez, J. Y.; Hodgkinson, A.

To demonstrate a Mixed Axial and Radial field System (MARS) as the best magnet scheme for future ECRISs, MARS-D, a demonstrative ECRIS using a NbTi MARS magnet is progressing at Lawrence Berkeley National Laboratory. An optimized MARS design can use either NbTi or Nb 3Sn coils with reduced engineering complexities to construct the needed high-field magnets. The optimized magnet design could enhance MARS-D to a next generation ECRIS by producing minimum-B field maxima of 5.6 T axially and 3.2 T radially for operating frequencies up to 45 GHz. Lastly, in-progress test winding has achieved a milestone demonstrating the fabrication feasibilitymore » of a MARS closed-loop coil.« less

Design and evaluation of a chronic EMG multichannel detection system for long-term recordings of hindlimb muscles in behaving mice

PubMed Central

Tysseling, Vicki M.; Janes, Lindsay; Imhoff, Rebecca; Quinlan, Katharina A.; Lookabaugh, Brad; Ramalingam, Shyma; Heckman, C.J.; Tresch, Matthew C.

2013-01-01

Mouse models are commonly used for identifying the behavioral consequences of genetic modifications, progression or recovery from disease or trauma models, and understanding spinal circuitry. Electromyographic recordings (EMGs) are recognized as providing information not possible from standard behavioral analyses involving gross behavioral or kinematic assessments. We describe here a method for recording from relatively large numbers of muscles in behaving mice. We demonstrate the use of this approach for recording from hindlimb muscles bilaterally in intact animals, following spinal cord injury, and during the progression of ALS. This design can be used in a variety of applications in order to characterize the coordination strategies of mice in health and disease. PMID:23369875

Progress toward Topology Optimization (TO) for Additive Manufacturing (AM) and Fatigue

DTIC Science & Technology

2017-06-15

traditional manufacturing processes due to cost, tool-path constraints, or operator limitations. While AM significantly widens the design space for TO... manufacturing constraints and limitations remain1 and should be addressed in the design process. An objective of this work is to consider manufacturing ...account for AM limitations within the design . The limitations of interest in this work are the production of support material and enclosed pores. Both

Designing application software in wide area network settings

NASA Technical Reports Server (NTRS)

Makpangou, Mesaac; Birman, Ken

1990-01-01

Progress in methodologies for developing robust local area network software has not been matched by similar results for wide area settings. The design of application software spanning multiple local area environments is examined. For important classes of applications, simple design techniques are presented that yield fault tolerant wide area programs. An implementation of these techniques as a set of tools for use within the ISIS system is described.

Requiem for a Data Base System.

DTIC Science & Technology

1979-01-18

were defined -- - 2) the final syntax and semantics of QUEL were defined 3) protection was figured out 14) EQUEL was designed 5) concurrency control and...features which were not thought about in the initial design (such as concurrency control and recovery) and began worrying about distributed data...made in progress rather than on eventual corrections. Some attention is also given to the role of structured design in a data base system implementation

Silicon production process evaluations

NASA Technical Reports Server (NTRS)

1981-01-01

The chemical engineering analysis of the preliminary process design of a process for producing solar cell grade silicon from dichlorosilane is presented. A plant to produce 1,000 MT/yr of silicon is analyzed. Progress and status for the plant design are reported for the primary activities of base case conditions (60 percent), reaction chemistry (50 percent), process flow diagram (35 percent), energy balance (10 percent), property data (10 percent) and equipment design (5 percent).

Alternatives for jet engine control

NASA Technical Reports Server (NTRS)

Sain, M. K.

1983-01-01

The technical progress of researches on alternatives for jet engine control, is reported. The principal new activities involved the initial testing of an input design method for choosing the inputs to a non-linear system to aid the approximation of its tensor parameters, and the beginning of order reduction studies designed to remove unnecessary monomials from tensor models.

A CURRICULUM DESIGN FOR DISADVANTAGED COMMUNITY JUNIOR COLLEGE STUDENTS.

ERIC Educational Resources Information Center

CLARKE, JOHNNIE RUTH

THE JUNIOR COLLEGE MUST DEVELOP A CURRICULUM DESIGNED TO MEET THE IDENTIFIABLE EDUCATIONAL NEEDS OF THE DISADVANTAGED STUDENT, WITH SPECIFIC REFERENCE TO THE EFFECTS OF DEPRIVATION ON ASPIRATIONS, VALUES, MOTIVATION, AND SELF-CONCEPT AND TO THE INFLUENCE OF CLASS OR CASTE ON ACADEMIC PROGRESS. THIS STUDENT NEEDS TO DEVELOP (1) POSITIVE FEELINGS OF…

Accounting Training Module Development to Boost Agriculture Financial Literacy on Palm Farmers

ERIC Educational Resources Information Center

Hasibuan, Henny Triyana; Murwani, Danardana; Widjaja, Sri Umi Mientarti; Witjaksono, Mit

2017-01-01

This research aims to develop agriculture accounting training module in order to increase palm oil farmer financial literacy, in this case farmers in Donomulyo, Malang Regency, Indonesia. The method utilized in model development is Design Based Research using the following progression: problem identification, explanation of goals, design and…

Designs for Progress in Science Education.

ERIC Educational Resources Information Center

Butts, David P.

This book, prepared as a part of the activities of the National Science Teachers Association (NSTA) Silver Anniversary Year, is directed at setting forth designs for the future of science education which will benefit as equally as possible those who see science as a life-long intellectual adventure and occupation, those who commit themselves to…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batchelor, D.B.; Carreras, B.A.; Hirshman, S.P.

Significant progress has been made in the development of new modest-size compact stellarator devices that could test optimization principles for the design of a more attractive reactor. These are 3 and 4 field period low-aspect-ratio quasi-omnigenous (QO) stellarators based on an optimization method that targets improved confinement, stability, ease of coil design, low-aspect-ratio, and low bootstrap current.

Enhancing Critical Thinking across the Undergraduate Experience: An Exemplar from Engineering

ERIC Educational Resources Information Center

Ralston, Patricia A.; Bays, Cathy L.

2013-01-01

Faculty in a large, urban school of engineering designed a longitudinal study to assess the critical thinking skills of undergraduate students as they progressed through the engineering program. The Paul-Elder critical thinking framework was used to design course assignments and develop a holistic assessment rubric. The curriculum was re-designed…

PIRPOSAL Model of Integrative STEM Education: Conceptual and Pedagogical Framework for Classroom Implementation

ERIC Educational Resources Information Center

Wells, John G.

2016-01-01

The PIRPOSAL model is both a conceptual and pedagogical framework intended for use as a pragmatic guide to classroom implementation of Integrative STEM Education. Designerly questioning prompted by a "need to know" serves as the basis for transitioning student designers within and among multiple phases while they progress toward an…

The Impact of Mixing Modes on Reliability in Longitudinal Studies

ERIC Educational Resources Information Center

Cernat, Alexandru

2015-01-01

Mixed-mode designs are increasingly important in surveys, and large longitudinal studies are progressively moving to or considering such a design. In this context, our knowledge regarding the impact of mixing modes on data quality indicators in longitudinal studies is sparse. This study tries to ameliorate this situation by taking advantage of a…

Recent progress in the design and clinical development of electronic-nose technologies

Treesearch

Dan Wilson

2016-01-01

Electronic-nose (e-nose) devices are instruments designed to detect and discriminate between precise complex gaseous mixtures of volatile organic compounds derived from specific organic sources, such as clinical test samples from patients, based on electronic aroma signature patterns (distinct digital sensor responses) resulting from the combined outputs of a...

Multimedia Learning: Cognitive Individual Differences and Display Design Techniques Predict Transfer Learning with Multimedia Learning Modules

ERIC Educational Resources Information Center

Austin, Katherine A.

2009-01-01

In the wake of the information explosion and rapidly progressing technology [Mayer, R. E. (2001). "Multimedia learning". Cambridge: University Press] formulated a theory that focused on human cognition, rather than technology capacity and features. By measuring the effect of cognitive individual differences and display design manipulations on…

76 FR 5598 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-01

... major initiative designed to: (1) Prevent the onset and reduce the progression of substance abuse... evaluation design. Since the ultimate goal is to fund all eligible jurisdictions, there are no control groups... NOMs. Information for both surveys will be gathered by the grantees' evaluators twice over the life of...

76 FR 18567 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-04

... major initiative designed to: (1) Prevent the onset and reduce the progression of substance abuse... original evaluation design. Since the ultimate goal is to fund all eligible jurisdictions, there are no... NOMs. Information for both surveys will be gathered by the grantees' evaluators twice over the life of...

PLANNING STUDY--BEHAVIORAL FACTORS IN DENTAL SCHOOL DESIGN. SUMMARY PROGRESS REPORT.

ERIC Educational Resources Information Center

MYRICK, RICHARD

THIS REPORT DISCUSSES ENVIRONMENTAL CONSIDERATIONS IN THE DESIGN OF DENTAL SCHOOL FACILITIES AS RELATED TO THE EDUCATIONAL NEEDS OF STUDENTS AND FACULTY. TWO TYPES OF NEEDS ARE IDENTIFIED--(1) PHYSICAL, INCLUDING A FUNCTIONAL ANALYSIS OF THE PHYSICAL NEEDS IMPOSED BY THE TASKS TO BE DONE, AND (2) PSYCHOLOGICAL, INCLUDING MOTIVATIONAL, SOCIAL, AND…

Exploring Students' Progression in an Inquiry Science Curriculum Enabled by Mobile Learning

ERIC Educational Resources Information Center

Looi, Chee-Kit; Sun, Daner; Xie, Wenting

2015-01-01

The research literature reports on designs of ubiquitous and seamless learning environments enabled by the integration of mobile technology into learning. However, the lack of good pedagogical designs that provide for sustainability and the inadequate investigation of learning outcomes remain major gaps in the current studies on mobile learning.…

The Socratic Method: Empirical Assessment of a Psychology Capstone Course

ERIC Educational Resources Information Center

Burns, Lawrence R.; Stephenson, Paul L.; Bellamy, Katy

2016-01-01

Although students make some epistemological progress during college, most graduate without developing meaning-making strategies that reflect an understanding that knowledge is socially constructed. Using a pre-test-post-test design and a within-subjects 2 × 2 mixed-design ANOVA, this study reports on empirical findings which support the Socratic…

Design, development and evaluation of Stanford/Ames Extra-Vehicular Activity (EVA) prehensors

NASA Technical Reports Server (NTRS)

Leifer, Larry J.; Jameson, J.; Leblanc, M.; Wilson, D.; Sabelman, E.; Schwandt, D.

1987-01-01

A summary is given of progress to date on work proposed in 1983 and continued in 1985, including design iterations on three different types of manually powered prehensors, construction of functional mockups of each and culminating in detailed drawings and specifications for suit-compatible sealed units for testing under realistic conditions.

Open the Windows: Design New Spaces for Learning

ERIC Educational Resources Information Center

Johnson, Christopher

2011-01-01

As a technologist, the author is interested in how the digital world is changing the educational landscape. As he began to research effective learning spaces, he discovered that the architecture, design, and school facilities communities are making a great deal of progress in creating better classrooms and school buildings. Unfortunately, many in…

Smart Libraries: Integrating Communications Channels and Information Sources.

ERIC Educational Resources Information Center

Webb, T. D.; Jensen, E. A.

Noting that the changing nature of information delivery has established immediacy as the new basis for modern library service, this paper describes the new facilities design and floor plan for the library of Kapiolani Community College of the University of Hawaii. The new library was carefully designed so that students can move progressively from…

Progress in the planar CPn SOFC system design verification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elangovan, S.; Hartvigsen, J.; Khandkar, A.

1996-04-01

SOFCo is developing a high efficiency, modular and scaleable planar SOFC module termed the CPn design. This design has been verified in a 1.4 kW module test operated directly on pipeline natural gas. The design features multistage oxidation of fuel wherein the fuel is consumed incrementally over several stages. High efficiency is achieved by uniform current density distribution per stage, which lowers the stack resistance. Additional benefits include thermal regulation and compactness. Test results from stack modules operating in pipeline natural gas are presented.

Advanced wind turbine design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jamieson, P.M.; Jaffrey, A.

1995-09-01

Garrad Hassan have a project in progress funded by the UK Department of Trade and Industry (DTI) to assess the prospects and cost benefits of advanced wind turbine design. In the course of this work, a new concept, the coned rotor design, has been developed. This enables a wind turbine system to operate in effect with variable rotor diameter augmenting energy capture in light winds and shedding loads in storm conditions. Comparisons with conventional design suggest that a major benefit in reduced cost of wind generated electricity may be possible.

Advanced wind turbine design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jamieson, P.M.; Jaffrey, A.

1997-11-01

Garrad Hassan have a project in progress funded by the U.K. Department of Trade and Industry (DTI) to assess the prospects and cost benefits of advanced wind turbine design. In the course of this work, a new concept, the coned rotor design, has been developed. This enables a wind turbine system to operate in effect with variable rotor diameter augmenting energy capture in light winds and shedding loads in storm conditions. Comparisons with conventional design suggest that a major benefit in reduced cost of wind-generated electricity may be possible.

Five-Segment Solid Rocket Motor Development Status

NASA Technical Reports Server (NTRS)

Priskos, Alex S.

2012-01-01

In support of the National Aeronautics and Space Administration (NASA), Marshall Space Flight Center (MSFC) is developing a new, more powerful solid rocket motor for space launch applications. To minimize technical risks and development costs, NASA chose to use the Space Shuttle s solid rocket boosters as a starting point in the design and development. The new, five segment motor provides a greater total impulse with improved, more environmentally friendly materials. To meet the mass and trajectory requirements, the motor incorporates substantial design and system upgrades, including new propellant grain geometry with an additional segment, new internal insulation system, and a state-of-the art avionics system. Significant progress has been made in the design, development and testing of the propulsion, and avionics systems. To date, three development motors (one each in 2009, 2010, and 2011) have been successfully static tested by NASA and ATK s Launch Systems Group in Promontory, UT. These development motor tests have validated much of the engineering with substantial data collected, analyzed, and utilized to improve the design. This paper provides an overview of the development progress on the first stage propulsion system.

NAEP 1996 Science Report for Department of Defense Domestic Dependent Elementary and Secondary Schools. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

O'Sullivan, Christine Y.; Jerry, Laura; Ballator, Nada; Herr, Fiona

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

NAEP 1996 Science State Report for Department of Defense Domestic Dependent Elementary and Secondary Schools, Grade 4. Findings from the National Assessment of Educational Progress.

ERIC Educational Resources Information Center

Ballator, Nada; O'Sullivan, Christine Y.; Jerry, Laura

In 1990, the National Assessment of Educational Progress (NAEP) included a Trial State Assessment (TSA); for the first time in the NAEP's history, voluntary state-by-state assessments were made. The sample was designed to represent the 8th grade public school population in a state or territory. In 1996, 44 states, the District of Columbia, Guam,…

Recent Progress in Electromagnetic Absorption and Dosimetry in Biological Systems.

DTIC Science & Technology

1978-12-21

AEROSPACE M!DICAL RESEARCH LABORATORY NAVAL AIR STATION PENSACOLA, FLORIDA 32508 L4 oj6L I SUMMARY PAGE Ti9(PROSLEM Dosimetry , as a subset of research In...absonce of sound dosimetry design, lacks credibility. This study provides a usable orientation in present and future dosimetric technology through a...leading experiment; while at other times experimental results lead the way. Progress In absorption and dosimetry Is still urderway, and higher degrees

Design Document for 12th Grade NAEP Preparedness Research Judgmental Standard Setting Studies: Setting Standards on the National Assessment of Educational Progress in Reading and Mathematics for 12th Grade Preparedness

ERIC Educational Resources Information Center

National Assessment Governing Board, 2010

2010-01-01

The National Assessment Governing Board adopted a Program of Preparedness Research in March 2009. Several categories of research studies were recommended to produce results for reporting 12th grade preparedness for the 2009 grade 12 National Assessment of Educational Progress (NAEP) in reading and mathematics. The categories included content…

The Comprehensive, Powerful, Academic Database (CPAD): An Evaluative Study of a Predictive Tool Designed for Elementary School Personnel in Identifying At-Risk Students through Progress, Curriculum, and Performance Monitoring

ERIC Educational Resources Information Center

Chavez-Gibson, Sarah

2013-01-01

The purpose of this study is to exam in-depth, the Comprehensive, Powerful, Academic Database (CPAD), a data decision-making tool that determines and identifies students at-risk of dropping out of school, and how the CPAD assists administrators and teachers at an elementary campus to monitor progress, curriculum, and performance to improve student…

Role of design complexity in technology improvement.

PubMed

McNerney, James; Farmer, J Doyne; Redner, Sidney; Trancik, Jessika E

2011-05-31

We study a simple model for the evolution of the cost (or more generally the performance) of a technology or production process. The technology can be decomposed into n components, each of which interacts with a cluster of d - 1 other components. Innovation occurs through a series of trial-and-error events, each of which consists of randomly changing the cost of each component in a cluster, and accepting the changes only if the total cost of the cluster is lowered. We show that the relationship between the cost of the whole technology and the number of innovation attempts is asymptotically a power law, matching the functional form often observed for empirical data. The exponent α of the power law depends on the intrinsic difficulty of finding better components, and on what we term the design complexity: the more complex the design, the slower the rate of improvement. Letting d as defined above be the connectivity, in the special case in which the connectivity is constant, the design complexity is simply the connectivity. When the connectivity varies, bottlenecks can arise in which a few components limit progress. In this case the design complexity depends on the details of the design. The number of bottlenecks also determines whether progress is steady, or whether there are periods of stasis punctuated by occasional large changes. Our model connects the engineering properties of a design to historical studies of technology improvement.

Mechanical design of DNA nanostructures

NASA Astrophysics Data System (ADS)

Castro, Carlos E.; Su, Hai-Jun; Marras, Alexander E.; Zhou, Lifeng; Johnson, Joshua

2015-03-01

Structural DNA nanotechnology is a rapidly emerging field that has demonstrated great potential for applications such as single molecule sensing, drug delivery, and templating molecular components. As the applications of DNA nanotechnology expand, a consideration of their mechanical behavior is becoming essential to understand how these structures will respond to physical interactions. This review considers three major avenues of recent progress in this area: (1) measuring and designing mechanical properties of DNA nanostructures, (2) designing complex nanostructures based on imposed mechanical stresses, and (3) designing and controlling structurally dynamic nanostructures. This work has laid the foundation for mechanically active nanomachines that can generate, transmit, and respond to physical cues in molecular systems.Structural DNA nanotechnology is a rapidly emerging field that has demonstrated great potential for applications such as single molecule sensing, drug delivery, and templating molecular components. As the applications of DNA nanotechnology expand, a consideration of their mechanical behavior is becoming essential to understand how these structures will respond to physical interactions. This review considers three major avenues of recent progress in this area: (1) measuring and designing mechanical properties of DNA nanostructures, (2) designing complex nanostructures based on imposed mechanical stresses, and (3) designing and controlling structurally dynamic nanostructures. This work has laid the foundation for mechanically active nanomachines that can generate, transmit, and respond to physical cues in molecular systems. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr07153k

ISS Progress 24 Rollout

NASA Image and Video Library

2007-01-16

JSC2007-E-03079 (16 Jan. 2007) --- Roll-out of the Progress 24 vehicle occurred on schedule at 7:00 a.m., Jan. 16, 2007 (local time) at the Baikonur Cosmodrome, Kazakhstan. Progress 24 bears on the side of the Soyuz launch vehicle the name of Sergei Korolev, the "Great Designer" of Soviet spacecraft, whose 100th birthday was celebrated on Jan. 12. A portrait of him is painted on the external payload fairing. Korolev, named in his memory, is now the suburb of Moscow where the Russian Mission Control Center resides. After it reaches orbit, a series of pre-programmed engine firings will lead to the automated docking of Progress 24 to the now-vacant Pirs Docking Compartment at 9:00 p.m. CST on Jan. 19. (6:00 a.m. on Jan. 20, Moscow time). Photo Credit: NASA

Combined Population Dynamics and Entropy Modelling Supports Patient Stratification in Chronic Myeloid Leukemia

NASA Astrophysics Data System (ADS)

Brehme, Marc; Koschmieder, Steffen; Montazeri, Maryam; Copland, Mhairi; Oehler, Vivian G.; Radich, Jerald P.; Brümmendorf, Tim H.; Schuppert, Andreas

2016-04-01

Modelling the parameters of multistep carcinogenesis is key for a better understanding of cancer progression, biomarker identification and the design of individualized therapies. Using chronic myeloid leukemia (CML) as a paradigm for hierarchical disease evolution we show that combined population dynamic modelling and CML patient biopsy genomic analysis enables patient stratification at unprecedented resolution. Linking CD34+ similarity as a disease progression marker to patient-derived gene expression entropy separated established CML progression stages and uncovered additional heterogeneity within disease stages. Importantly, our patient data informed model enables quantitative approximation of individual patients’ disease history within chronic phase (CP) and significantly separates “early” from “late” CP. Our findings provide a novel rationale for personalized and genome-informed disease progression risk assessment that is independent and complementary to conventional measures of CML disease burden and prognosis.

Progress 7 Supply Vehicle Departs for Incineration

NASA Technical Reports Server (NTRS)

2002-01-01

The unpiloted Russian Progress 7 supply ship departs from the Zvezda Service Module's docking port on the International Space Station. Carrying its load of trash and urneeded equipment, it will be deorbited and burned up in the atmosphere. The undocking paves the way for the arrival of the new Progress 8, filled with fresh supplies. Soviet designers realized that long-duration missions in space would demand a constant supply of consumable materials from Earth. The cost-effective Progress spacecraft made possible an almost permanent presence in space and stands out as a single biggest contribution to this achievement. Propulsion and service systems were installed in the tail section of the vehicle and the cargo ship was inseparable during its entire flight. Upon conclusion of its supply mission to the Station, it would be directed into the atmosphere to burn up.

Natural history of Niemann-Pick disease type C in a multicentre observational retrospective cohort study.

PubMed

Wraith, J E; Guffon, N; Rohrbach, M; Hwu, W L; Korenke, G C; Bembi, B; Luzy, C; Giorgino, R; Sedel, F

2009-11-01

Niemann-Pick disease type C (NP-C) is a devastating genetic disorder characterised by progressive neurological deterioration. However, data on the progression of neurological manifestations, particularly across different patient age-of-disease onsets, are limited. This is an observational retrospective cohort study designed to assess the progression of neurological disease in patients with NP-C. Physicians were asked to retrospectively complete a web-based questionnaire for each patient, at diagnosis and at up to three follow-up visits. An NP-C-specific disability scale was used to measure disease progression. The scale comprised four key parameters of neurological disease progression; ambulation, manipulation, language and swallowing. Disease progression was evaluated based on the annual rate of change in each parameter and the composite score using a linear mixed model analysis, and by classifying patients according to the number of worsened parameters during the observation period. Data were collected from 57 patients. The rate of deterioration was similar across the four individual parameters of the disability scale. The mean (95% CI) annual disease progression was +0.12 (0.09, 0.15) units. Among patients with a time interval of at least 1 year between diagnosis and last visit (n=49), 42 (86%) patients had progressed disease and 7 (14%) patients had stable disease. Disease progression was consistently more rapid in patients diagnosed in early childhood, compared with those diagnosed in late childhood, or with juvenile or adult presentation. In conclusion, our findings showed a progression in all four parameters of the disability scale, representing a continuous, unbroken progression of neurological manifestations.

Using CFD as a Rocket Injector Design Tool: Recent Progress at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Tucker, Kevin; West, Jeff; Williams, Robert; Lin, Jeff; Canabal, Francisco; Rocker, marvin; Robles, Bryan; Garcia, Robert; Chenoweth, James

2005-01-01

New programs are forcing American propulsion system designers into unfamiliar territory. For instance, industry s answer to the cost and reliability goals set out by the Next Generation Launch Technology Program are engine concepts based on the Oxygen- Rich Staged Combustion Cycle. Historical injector design tools are not well suited for this new task. The empirical correlations do not apply directly to the injector concepts associated with the ORSC cycle. These legacy tools focus primarily on performance with environment evaluation a secondary objective. Additionally, the environmental capability of these tools is usually one-dimensional while the actual environments are at least two- and often three-dimensional. CFD has the potential to calculate performance and multi-dimensional environments but its use in the injector design process has been retarded by long solution turnaround times and insufficient demonstrated accuracy. This paper has documented the parallel paths of program support and technology development currently employed at Marshall Space Flight Center in an effort to move CFD to the forefront of injector design. MSFC has established a long-term goal for use of CFD for combustion devices design. The work on injector design is the heart of that vision and the Combustion Devices CFD Simulation Capability Roadmap that focuses the vision. The SRL concept, combining solution fidelity, robustness and accuracy, has been established as a quantitative gauge of current and desired capability. Three examples of current injector analysis for program support have been presented and discussed. These examples are used to establish the current capability at MSFC for these problems. Shortcomings identified from this experience are being used as inputs to the Roadmap process. The SRL evaluation identified lack of demonstrated solution accuracy as a major issue. Accordingly, the MSFC view of code validation and current MSFC-funded validation efforts were discussed in some detail. The objectives of each effort were noted. Issues relative to code validation for injector design were discussed in some detail. The requirement for CFD support during the design of the experiment was noted and discussed in terms of instrumentation placement and experimental rig uncertainty. In conclusion, MSFC has made significant progress in the last two years in advancing CFD toward the goal of application to injector design. A parallel effort focused on program support and technology development via the SCIT Task have enabled the progress.

Assessment of Retinal Nerve Fiber Layer Using Optical Coherence Tomography and Scanning Laser Polarimetry in Progressive Glaucomatous Optic Neuropathy

PubMed Central

Sehi, Mitra; Greenfield, David S.

2006-01-01

Purpose To describe a case of progressive glaucomatous optic neuropathy using scanning laser polarimetry with fixed (SLP-FCC) and variable corneal compensation (SLP-VCC) and optical coherence tomography (OCT). Design Observational case report. Methods A 21-year-old male with juvenile primary open-angle glaucoma developed progression because of noncompliance with therapy. The patient underwent dilated stereoscopic examination and photography of the optic disk, standard automated perimetry (SAP), OCT, and SLP imaging with FCC and VCC at the baseline examination and after four years of follow-up. Results Optic disk, retinal nerve fiber layer (RNFL) atrophy, and SAP progression was observed. Reduction in mean RNFL thickness (average, superior, inferior) was 18, 18, and 27 microns (OCT); 22, 40, and 17 microns (SLP-FCC); and 6, 12, and 12 microns (SLP-VCC), respectively. Conclusions This case demonstrates that digital imaging of the peripapillary RNFL is capable of documentation and measurement of progressive glaucomatous RNFL atrophy. PMID:17157591

On the importance of accounting for competing risks in pediatric cancer trials designed to delay or avoid radiotherapy: I. Basic concepts and first analyses.

PubMed

Tai, Bee-Choo; Grundy, Richard G; Machin, David

2010-04-01

In trials designed to delay or avoid irradiation among children with malignant brain tumor, although irradiation after disease progression is an important event, patients who have disease progression may decline radiotherapy (RT), or those without disease progression may opt for elective RT. To accurately describe the cumulative need for RT in such instances, it is crucial to account for these distinct events and to evaluate how each contributes to the delay or advancement of irradiation via a competing risks analysis. We describe the summary of competing events in such trials using competing risks methods based on cumulative incidence functions and Gray's test. The results obtained are contrasted with standard survival methods based on Kaplan-Meier curves, cause-specific hazard functions and log-rank test. The Kaplan-Meier method overestimates all event-specific rates. The cause-specific hazard analysis showed reduction in hazards for all events (A: RT after progression; B: no RT after progression; C: elective RT) among children with ependymoma. For event A, a higher cumulative incidence was reported for ependymoma. Although Gray's test failed to detect any difference (p = 0.331) between histologic subtypes, the log-rank test suggested marginal evidence (p = 0.057). Similarly, for event C, the log-rank test found stronger evidence of reduction in hazard among those with ependymoma (p = 0.005) as compared with Gray's test (p = 0.086). To evaluate treatment differences, failing to account for competing risks using appropriate methodology may lead to incorrect interpretations.

A framework for prospectively defining progression rules for internal pilot studies monitoring recruitment.

PubMed

Hampson, Lisa V; Williamson, Paula R; Wilby, Martin J; Jaki, Thomas

2017-01-01

Just over half of publicly funded trials recruit their target sample size within the planned study duration. When recruitment targets are missed, the funder of a trial is faced with the decision of either committing further resources to the study or risk that a worthwhile treatment effect may be missed by an underpowered final analysis. To avoid this challenging situation, when there is insufficient prior evidence to support predicted recruitment rates, funders now require feasibility assessments to be performed in the early stages of trials. Progression criteria are usually specified and agreed with the funder ahead of time. To date, however, the progression rules used are typically ad hoc. In addition, rules routinely permit adaptations to recruitment strategies but do not stipulate criteria for evaluating their effectiveness. In this paper, we develop a framework for planning and designing internal pilot studies which permit a trial to be stopped early if recruitment is disappointing or to continue to full recruitment if enrolment during the feasibility phase is adequate. This framework enables a progression rule to be pre-specified and agreed upon prior to starting a trial. The novel two-stage designs stipulate that if neither of these situations arises, adaptations to recruitment should be made and subsequently evaluated to establish whether they have been successful. We derive optimal progression rules for internal pilot studies which minimise the expected trial overrun and maintain a high probability of completing the study when the recruitment rate is adequate. The advantages of this procedure are illustrated using a real trial example.

Architecture for Integrated Medical Model Dynamic Probabilistic Risk Assessment

NASA Technical Reports Server (NTRS)

Jaworske, D. A.; Myers, J. G.; Goodenow, D.; Young, M.; Arellano, J. D.

2016-01-01

Probabilistic Risk Assessment (PRA) is a modeling tool used to predict potential outcomes of a complex system based on a statistical understanding of many initiating events. Utilizing a Monte Carlo method, thousands of instances of the model are considered and outcomes are collected. PRA is considered static, utilizing probabilities alone to calculate outcomes. Dynamic Probabilistic Risk Assessment (dPRA) is an advanced concept where modeling predicts the outcomes of a complex system based not only on the probabilities of many initiating events, but also on a progression of dependencies brought about by progressing down a time line. Events are placed in a single time line, adding each event to a queue, as managed by a planner. Progression down the time line is guided by rules, as managed by a scheduler. The recently developed Integrated Medical Model (IMM) summarizes astronaut health as governed by the probabilities of medical events and mitigation strategies. Managing the software architecture process provides a systematic means of creating, documenting, and communicating a software design early in the development process. The software architecture process begins with establishing requirements and the design is then derived from the requirements.

24 CFR 598.620 - Evaluation, monitoring, and enforcement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES URBAN EMPOWERMENT ZONES: ROUND TWO AND THREE DESIGNATIONS Empowerment Zone Grants § 598.620 Evaluation, monitoring, and enforcement. (a) Progress...

24 CFR 598.620 - Evaluation, monitoring, and enforcement.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES URBAN EMPOWERMENT ZONES: ROUND TWO AND THREE DESIGNATIONS Empowerment Zone Grants § 598.620 Evaluation, monitoring, and enforcement. (a) Progress...

A review of statistical issues with progression-free survival as an interval-censored time-to-event endpoint.

PubMed

Sun, Xing; Li, Xiaoyun; Chen, Cong; Song, Yang

2013-01-01

Frequent rise of interval-censored time-to-event data in randomized clinical trials (e.g., progression-free survival [PFS] in oncology) challenges statistical researchers in the pharmaceutical industry in various ways. These challenges exist in both trial design and data analysis. Conventional statistical methods treating intervals as fixed points, which are generally practiced by pharmaceutical industry, sometimes yield inferior or even flawed analysis results in extreme cases for interval-censored data. In this article, we examine the limitation of these standard methods under typical clinical trial settings and further review and compare several existing nonparametric likelihood-based methods for interval-censored data, methods that are more sophisticated but robust. Trial design issues involved with interval-censored data comprise another topic to be explored in this article. Unlike right-censored survival data, expected sample size or power for a trial with interval-censored data relies heavily on the parametric distribution of the baseline survival function as well as the frequency of assessments. There can be substantial power loss in trials with interval-censored data if the assessments are very infrequent. Such an additional dependency controverts many fundamental assumptions and principles in conventional survival trial designs, especially the group sequential design (e.g., the concept of information fraction). In this article, we discuss these fundamental changes and available tools to work around their impacts. Although progression-free survival is often used as a discussion point in the article, the general conclusions are equally applicable to other interval-censored time-to-event endpoints.

Development of the ITER magnetic diagnostic set and specification.

PubMed

Vayakis, G; Arshad, S; Delhom, D; Encheva, A; Giacomin, T; Jones, L; Patel, K M; Pérez-Lasala, M; Portales, M; Prieto, D; Sartori, F; Simrock, S; Snipes, J A; Udintsev, V S; Watts, C; Winter, A; Zabeo, L

2012-10-01

ITER magnetic diagnostics are now in their detailed design and R&D phase. They have passed their conceptual design reviews and a working diagnostic specification has been prepared aimed at the ITER project requirements. This paper highlights specific design progress, in particular, for the in-vessel coils, steady state sensors, saddle loops and divertor sensors. Key changes in the measurement specifications, and a working concept of software and electronics are also outlined.

Progressive Design of Plasmonic Metal-Semiconductor Ensemble toward Regulated Charge Flow and Improved Vis-NIR-Driven Solar-to-Chemical Conversion.

PubMed

Han, Chuang; Quan, Quan; Chen, Hao Ming; Sun, Yugang; Xu, Yi-Jun

2017-04-01

Surface plasmon resonance (SPR)-mediated photocatalysis without the bandgap limitations of traditional semiconductor has aroused significant attention in solar-to-chemical energy conversion. However, the photocatalytic efficiency barely initiated by the SPR effects is still challenged by the low concentration and ineffective extraction of energetic hot electrons, slow charge migration rates, random charge diffusion directions, and the lack of highly active sites for redox reactions. Here, the tunable, progressive harvesting of visible-to-near infrared light (vis-NIR, λ > 570 nm) by designing plasmonic Au nanorods and metal (Au, Ag, or Pt) nanoparticle codecorated 1D CdS nanowire (1D CdS NW) ensemble is reported. The intimate integration of these metal nanostructures with 1D CdS NWs promotes the extraction and manipulated directional separation and migration of hot charge carriers in a more effective manner. Such cooperative synergy with tunable control of interfacial interaction, morphology optimization, and cocatalyst strategy results in the distinctly boosted performance for vis-NIR-driven plasmonic photocatalysis. This work highlights the significance of rationally progressive design of plasmonic metal-semiconductor-based composite system for boosting the regulated directional flow of hot charge carrier and thus the more efficient use of broad-spectrum solar energy conversion. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Progressive Stochastic Reconstruction Technique (PSRT) for cryo electron tomography.

PubMed

Turoňová, Beata; Marsalek, Lukas; Davidovič, Tomáš; Slusallek, Philipp

2015-03-01

Cryo Electron Tomography (cryoET) plays an essential role in Structural Biology, as it is the only technique that allows to study the structure of large macromolecular complexes in their close to native environment in situ. The reconstruction methods currently in use, such as Weighted Back Projection (WBP) or Simultaneous Iterative Reconstruction Technique (SIRT), deliver noisy and low-contrast reconstructions, which complicates the application of high-resolution protocols, such as Subtomogram Averaging (SA). We propose a Progressive Stochastic Reconstruction Technique (PSRT) - a novel iterative approach to tomographic reconstruction in cryoET based on Monte Carlo random walks guided by Metropolis-Hastings sampling strategy. We design a progressive reconstruction scheme to suit the conditions present in cryoET and apply it successfully to reconstructions of macromolecular complexes from both synthetic and experimental datasets. We show how to integrate PSRT into SA, where it provides an elegant solution to the region-of-interest problem and delivers high-contrast reconstructions that significantly improve template-based localization without any loss of high-resolution structural information. Furthermore, the locality of SA is exploited to design an importance sampling scheme which significantly speeds up the otherwise slow Monte Carlo approach. Finally, we design a new memory efficient solution for the specimen-level interior problem of cryoET, removing all associated artifacts. Copyright © 2015 Elsevier Inc. All rights reserved.

Progress on DCLL Blanket Concept

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wong, Clement; Abdou, M.; Katoh, Yutai

2013-09-01

Under the US Fusion Nuclear Science and Technology Development program, we have selected the Dual Coolant Lead Lithium concept (DCLL) as a reference blanket, which has the potential to be a high performance DEMO blanket design with a projected thermal efficiency of >40%. Reduced activation ferritic/martensitic (RAF/M) steel is used as the structural material. The self-cooled breeder PbLi is circulated for power conversion and for tritium breeding. A SiC-based flow channel insert (FCI) is used as a means for magnetohydrodynamic pressure drop reduction from the circulating liquid PbLi and as a thermal insulator to separate the high-temperature PbLi (~700°C) frommore » the helium-cooled RAF/M steel structure. We are making progress on related R&D needs to address critical Fusion Nuclear Science and Facility (FNSF) and DEMO blanket development issues. When performing the function as the Interface Coordinator for the DCLL blanket concept, we had been developing the mechanical design and performing neutronics, structural and thermal hydraulics analyses of the DCLL TBM module. We had estimated the necessary ancillary equipment that will be needed at the ITER site and a detailed safety impact report has been prepared. This provided additional understanding of the DCLL blanket concept in preparation for the FNSF and DEMO. This paper will be a summary report on the progress of the DCLL TBM design and R&Ds for the DCLL blanket concept.« less

An acoustic charge transport imager for high definition television applications

NASA Technical Reports Server (NTRS)

Hunt, W. D.; Brennan, K. F.; Summers, C. J.

1994-01-01

The primary goal of this research is to develop a solid-state television (HDTV) imager chip operating at a frame rate of about 170 frames/sec at 2 Megapixels/frame. This imager will offer an order of magnitude improvements in speed over CCD designs and will allow for monolithic imagers operating from the IR to UV. The technical approach of the project focuses on the development of the three basic components of the imager and their subsequent integration. The camera chip can be divided into three distinct functions: (1) image capture via an array of avalanche photodiodes (APD's); (2) charge collection, storage, and overflow control via a charge transfer transistor device (CTD); and (3) charge readout via an array of acoustic charge transport (ACT) channels. The use of APD's allows for front end gain at low noise and low operating voltages while the ACT readout enables concomitant high speed and high charge transfer efficiency. Currently work is progressing towards the optimization of each of these component devices. In addition to the development of each of the three distinct components, work towards their integration and manufacturability is also progressing. The component designs are considered not only to meet individual specifications but to provide overall system level performance suitable for HDTV operation upon integration. The ultimate manufacturability and reliability of the chip constrains the design as well. The progress made during this period is described in detail.

ISO Guest Observer Data Analysis and LWS Instrument Team Activities

NASA Technical Reports Server (NTRS)

Smith, Howard

2001-01-01

The following is an interim annual report. Dr. Smith is currently on an extended TDY to the Istituto di Fisica dello Spazio Interplanetario (IFSI) at the Consilio Nazionale delle Richerche (CNR) in Rome, Italy, where he has been working on a related NASA grant in support of analysis of Infrared Space Observatory (ISO) data on star formation in Ultra Luminous Infrared Galaxies and our galaxy. Work emphasizes development of metal mesh grids for use in spacecraft, and the design and fabrication of test elements by the Naval Research Laboratory, Washington D.C. Work has progressed well, but slowly, on that program due to the departure of a key engineer. NASA has been advised of the delay, and granted a no-cost extension, whereby SAO has authorized a delay in the final report from NRL. Nevertheless NRL has continued to make progress. Two papers have been submitted to refereed journals related to this program, and a new design for mesh operating in the 20-40 micron region has been developed. Meetings continue through the summer on these items. A new technical scientist has been made a job offer and hopefully will be on board NRL shortly, although most of the present grant work is already completed. A more complete report, with copies of the submitted papers, designs, and other measures of progress, will be submitted to NASA in September when Dr. Smith returns from his current TDY.

High-Pressure Turbulent Flame Speeds and Chemical Kinetics of Syngas Blends with and without Impurities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, Eric; Mathieu, Olivier; Morones, Anibal

2014-12-01

This Topical Report documents the first year of the project, from October 1, 2013 through September 30, 2014. Efforts for this project included experiments to characterize the atmospheric-pressure turbulent flame speed vessel over a range of operating conditions (fan speeds and turbulent length scales). To this end, a new LDV system was acquired and set up for the detailed characterization of the turbulence field. Much progress was made in the area of impurity kinetics, which included a numerical study of the effect of impurities such as NO2, NO, H2S, and NH3 on ignition delay times and laminar flame speeds ofmore » syngas blends at engine conditions. Experiments included a series of laminar flame speed measurements for syngas (CO/H2) blends with various levels of CH4 and C2H6 addition, and the results were compared to the chemical kinetics model of NUI Galway. Also, a final NOx kinetics mechanism including ammonia was assembled, and a journal paper was written and is now in press. Overall, three journal papers and six conference papers related to this project were published this year. Finally, much progress was made on the design of the new high-pressure turbulent flame speed facility. An overall design that includes a venting system was decided upon, and the detailed design is in progress.« less

Cell Division Synchronization

DTIC Science & Technology

The report summarizes the progress in the design and construction of automatic equipment for synchronizing cell division in culture by periodic...Concurrent experiments in hypothermic synchronization of algal cell division are reported.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The primary objective of this project is to establish the commercial readiness of MW-class IMHEX Molten Carbonate Fuel Cell power plants. Progress is described on marketing, systems design and analysis, product options and manufacturing.

24 CFR 597.401 - Periodic performance reviews.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF... regularly evaluate the progress of the strategic plan in each designated Empowerment Zone and Enterprise...

Recent Progress of Microfluidics in Translational Applications

PubMed Central

Liu, Zongbin; Han, Xin

2016-01-01

Microfluidics, featuring microfabricated structures, is a technology for manipulating fluids at the micrometer scale. The small dimension and flexibility of microfluidic systems are ideal for mimicking molecular and cellular microenvironment, and show great potential in translational research and development. Here, the recent progress of microfluidics in biological and biomedical applications, including molecular analysis, cellular analysis, and chip-based material delivery and biomimetic design is presented. The potential future developments in the translational microfluidics field are also discussed. PMID:27091777

Biomass power for rural development. Technical progress report, January 1--March 31, 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuhauser, E.

Brief progress reports are presented on the following tasks: design packages for retrofits at the Dunkirk Station; fuel supply and site development plans; major equipment guarantees and project risk sharing; power production commitment; power plant site plan, construction and environmental permits; and experimental strategies for system evaluation. The paper then discusses in more detail the following: feedstock development efforts; clone-site testing and genetic studies; and efforts at outreach, extension and technology transfer.

Positioning Vascularized Composite Allotransplantation within the Spectrum of Transplantation

DTIC Science & Technology

2016-10-01

In the third year of this grant, we made significant progress using our rat osteomyocutaneous flap model to study the effect of rejection on...submitted in the first quarter of year 4. We have also made significant progress in using the Vevo 2100 in imaging vasculopathy in the rat model, as...transplant biopsy timepoints, with multiple slides per timepoint to scan, as well as selected slides of the rat hind-limb project that are designated for

Monte Carlos of the new generation: status and progress

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frixione, Stefano

2005-03-22

Standard parton shower monte carlos are designed to give reliable descriptions of low-pT physics. In the very high-energy regime of modern colliders, this is may lead to largely incorrect predictions of the basic reaction processes. This motivated the recent theoretical efforts aimed at improving monte carlos through the inclusion of matrix elements computed beyond the leading order in QCD. I briefly review the progress made, and discuss bottom production at the Tevatron.

Mitochondrial DNA Mutations in Epithelial Ovarian Tumor Progression

DTIC Science & Technology

2007-12-01

of the author( s ) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other...Epithelial Ovarian Tumor Progression 5b. GRANT NUMBER W81XWH-05-1-0054 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Felix O. Aikhionbare, Ph.D. 5d...PROJECT NUMBER 5e. TASK NUMBER E-Mail: faikhionbare@msm.edu 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8

The Use of Organising Purposes in Science Instruction as a Scaffolding Mechanism to Support Progressions: A Study of Talk in Two Primary Science Classrooms

ERIC Educational Resources Information Center

Johansson, Annie-Maj; Wickman, Per-Olof

2018-01-01

Purpose: This study examines how different purposes can support teachers in their work with progressions as a part of a teaching sequences in science in primary school. Design/Method: The study was carried out in two classes working with inquiry and the events that took place in the classroom were filmed. In the study, we have chosen to use the…

Autologous mesenchymal stem cell therapy for progressive supranuclear palsy: translation into a phase I controlled, randomized clinical study

PubMed Central

2014-01-01

Background Progressive Supranuclear Palsy (PSP) is a sporadic and progressive neurodegenerative disease which belongs to the family of tauopathies and involves both cortical and subcortical structures. No effective therapy is to date available. Methods/design Autologous bone marrow (BM) mesenchymal stem cells (MSC) from patients affected by different type of parkinsonisms have shown their ability to improve the dopaminergic function in preclinical and clinical models. It is also possible to isolate and expand MSC from the BM of PSP patients with the same proliferation rate and immuphenotypic profile as MSC from healthy donors. BM MSC can be efficiently delivered to the affected brain regions of PSP patients where they can exert their beneficial effects through different mechanisms including the secretion of neurotrophic factors. Here we propose a randomized, placebo-controlled, double-blind phase I clinical trial in patients affected by PSP with MSC delivered via intra-arterial injection. Discussion To our knowledge, this is the first clinical trial to be applied in a no-option parkinsonism that aims to test the safety and to exploit the properties of autologous mesenchymal stem cells in reducing disease progression. The study has been designed to test the safety of this “first-in-man” approach and to preliminarily explore its efficacy by excluding the placebo effect. Trial registration NCT01824121 PMID:24438512

An experimental evaluation of patient decision aid design to communicate the effects of medications on the rate of progression of structural joint damage in rheumatoid arthritis.

PubMed

Martin, Richard W; Brower, Matthew E; Geralds, Alexander; Gallagher, Patience J; Tellinghuisen, Donald J

2012-03-01

To explore how effectively information presentation formats used in a patient decision aid communicated the ability of a disease modifying anti-rheumatic drug to slow the rate of progression of rheumatoid arthritis related structural joint damage (SJD). 91 first year psychology students and 91 RA patients participated in a prospective randomized, single blind, factorial experimental design evaluating the effect of four information formats on: satisfaction with risk communication, verbatim and gist recall of a hypothetical anti-rheumatic drug's ability to slow the rate of progression of SJD. Both groups underestimated the hypothetical drug's ability to slow SJD. Formats that supported the narrative statement with a reinforcing graphic element resulted in recall closer to the true value. Comparison of the results from testing of RA patients and college students were remarkably similar across formats. Rate of progression as communicated by narrative statement plus a graphic element (i.e. speedometer metaphor or pictograph) aided recall better than a narrative statement alone. Our results suggest that testing decision aid components with non-patients may provide data generalizable to patient populations. Graphics must be used carefully in patient decision aids as they can enhance recall, but may also introduce unintended recall bias. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Progress with the implementation of kangaroo mother care in four regions in Ghana.

PubMed

Bergh, A-M; Manu, R; Davy, K; Van Rooyen, E; Quansah Asare, G; Awoonor-Williams, Jk; Dedzo, M; Twumasi, A; Nang-Beifubah, A

2013-06-01

To measure progress with the implementation of kangaroo mother care (KMC) for low birth-weight (LBW) infants at a health systems level. Action research design, with district and regional hospitals as the unit of analysis. Four regions in Ghana, identified by the Ghana Health Service and UNICEF. Health workers and officials, health care facilities and districts in the four regions. A one-year implementation programme with three phases: (1) introduction to KMC, skills development in KMC practice and the management of implementation; (2) advanced skills development for regional steering committee members; and (3) an assessment of progress at the end of the intervention. Description of practices, services and facilities for KMC and the identification of strengths and challenges. Twenty-six of 38 hospitals (68%) demonstrated sufficient progress with KMC implementation. Half of the hospitals had designated a special ward for KMC. 66% of hospitals used a special record for infants receiving KMC. Two of the main challenges were lack of support for mothers who had to remain with their LBW infants in hospital and no follow-up review services for LBW infants in 39% of hospitals. It was possible to roll out KMC in Ghana, but further support for the regions is needed to maintain the momentum. Lessons learned from this project could inform further scale-up of KMC and other projects in Ghana.

Identity, Status, and Culture: Examining Barriers of Success for Students from Low Socioeconomic Backgrounds

ERIC Educational Resources Information Center

Walker, Anthony

2014-01-01

Dewey (1916) described the attainment of education as a necessary tool for the establishment and sustainability of progress. Education, attending to the good of the public, is designed to instill knowledge in the constituencies it serves (Kezar 2005). Further, Woods (2004) described the design of education, its services and responsibilities, as an…

Design and Application of Interactive Simulations in Problem-Solving in University-Level Physics Education

ERIC Educational Resources Information Center

Ceberio, Mikel; Almudí, José Manuel; Franco, Ángel

2016-01-01

In recent years, interactive computer simulations have been progressively integrated in the teaching of the sciences and have contributed significant improvements in the teaching-learning process. Practicing problem-solving is a key factor in science and engineering education. The aim of this study was to design simulation-based problem-solving…

Human Factors in the Design of a Computer-Assisted Instruction System. Technical Progress Report.

ERIC Educational Resources Information Center

Mudge, J. C.

A research project built an author-controlled computer-assisted instruction (CAI) system to study ease-of-use factors in student-system, author-system, and programer-system interfaces. Interfaces were designed and observed in use and systematically revised. Development of course material by authors, use by students, and administrative tasks were…

Measurement Approach to Teaching Fractions: A Design Experiment in a Pre-Service Course for Elementary Teachers

ERIC Educational Resources Information Center

Bobos, Georgeana; Sierpinska, Anna

2017-01-01

In this paper, we present a design experiment in a "Teaching Mathematics" course for prospective elementary teachers where we sought to develop a "measurement approach" to fractions. We focus on the conceptualization of the mathematical content of the approach. We attribute our progress in the conceptualization to our efforts…

Shock Timing Plan for the National Ignition Campaign

NASA Astrophysics Data System (ADS)

Munro, D. H.; Robey, H. F.; Spears, B. K.; Boehly, T. R.

2006-10-01

We report progress on the design of the shock timing tuning procedure for the 2010 ignition campaign at the National Ignition Facility. Our keyhole target design provides adequate drive surrogacy for us to time the first three shocks empirically. The major risk to our plan is hard x-ray preheat, which can cause the diagnostic window to become opaque.

A Framework for the Design and Integration of Collaborative Classroom Games

ERIC Educational Resources Information Center

Echeverria, Alejandro; Garcia-Campo, Cristian; Nussbaum, Miguel; Gil, Francisca; Villalta, Marco; Amestica, Matias; Echeverria, Sebastian

2011-01-01

The progress registered in the use of video games as educational tools has not yet been successfully transferred to the classroom. In an attempt to close this gap, a framework was developed that assists in the design and classroom integration of educational games. The framework addresses both the educational dimension and the ludic dimension. The…

Improvements in Limb Kinetic Apraxia by Repetition of a Newly Designed Facilitation Exercise in a Patient with Corticobasal Degeneration

ERIC Educational Resources Information Center

Kawahira, Kazumi; Noma, Tomokazu; Iiyama, Junichi; Etoh, Seiji; Ogata, Atsuko; Shimodozono, Megumi

2009-01-01

Corticobasal degeneration is a progressive neurological disorder characterized by a combination of parkinsonism and cortical dysfunction such as limb kinetic apraxia, alien limb phenomenon, and dementia. To study the effect of repetitive facilitation exercise (RFE) in a patient with corticobasal degeneration, we used a newly designed facilitation…

Designing a Task Based Curriculum for Intensive Language Training

ERIC Educational Resources Information Center

Elshoff, Joost

2014-01-01

In this paper, I will report on the progress made in designing a curriculum for intensive language training, in which one-on-one instruction is combined with online exercises and drills to achieve an optimal blend of expertise and technology enhanced language learning. The Common European Framework of Reference (CEFR) has become a crucial tool for…

Knowledge Management in Malaysian School Education: Do the Smart Schools Do It Better?

ERIC Educational Resources Information Center

Awang, Marinah; Ismail, Ramlee; Flett, Peter; Curry, Adrienne

2011-01-01

Purpose: The purpose of this paper is to shed light on changes in the Malaysian education system, with particular reference to the development of Smart Schools, and to evaluate progress with respect to knowledge management in school education. Design/methodology/approach: The research is designed around questionnaires based on a knowledge…

PROGRAMED SELF-INSTRUCTION IN MANDARIN CHINESE, OBSERVATIONS OF STUDENT PROGRESS WITH AN AUTOMATED AUDIO-VISUAL INSTRUCTIONAL DEVICE.

ERIC Educational Resources Information Center

CARROLL, JOHN B.

RESEARCH WAS UNDERTAKEN TO DETERMINE WHETHER SPOKEN AND WRITTEN FOREIGN LANGUAGE SKILLS COULD BE TAUGHT BY PROGRAMED SELF-INSTRUCTION USING THE MOST PRACTICAL AND WELL-DESIGNED AUDIOVISUAL TECHNIQUES AVAILABLE. THE PRESENTATION DEVICE, OR TEACHING MACHINE, WAS DESIGNED AND CONSTRUCTED TO SERVE THE SPECIAL REQUIREMENTS OF PROGRAMED SELF-INSTRUCTION…

40 CFR 62.14560 - How do I comply with the increment of progress for submittal of a control plan?

Code of Federal Regulations, 2010 CFR

2010-07-01

... DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements for Commercial and Industrial Solid Waste Incineration Units That Commenced Construction On or Before November 30, 1999 Compliance Schedule and... requirements of this subpart. (2) The type(s) of waste to be burned. (3) The maximum design waste burning...

40 CFR 62.14560 - How do I comply with the increment of progress for submittal of a control plan?

Code of Federal Regulations, 2011 CFR

2011-07-01

... DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements for Commercial and Industrial Solid Waste Incineration Units That Commenced Construction On or Before November 30, 1999 Compliance Schedule and... requirements of this subpart. (2) The type(s) of waste to be burned. (3) The maximum design waste burning...

Assessing the Progress of New American Schools: A Status Report.

ERIC Educational Resources Information Center

Berends, Mark

This report presents a data-collection plan for addressing these questions: (1) What were the New American Schools (NAS) like before they implemented their restructuring design efforts? (2) How have these evolved over time? (3) Are the critical components of the NAS designs being implemented across a wide array of schools? (4) Do the NAS designs…

EVALUATING POLLUTION PREVENTION PROGRESS (P2P) III: AN ENVIRONMENTAL TOOL FOR SCREENING IN PRODUCT LIFE CYCLE ASSESSMENT AND CHEMICAL PROCESS DESIGN

EPA Science Inventory

P2P is a computer-based tool that supports the comparison of process and product alternatives in terms of environmental impacts. This tool provides screening-level information for use in process design and in product LCA. Twenty one impact categories and data for approximately ...

Designing Sustainable Funding for College Promise Initiatives. Policy Information Report and ETS Research Report Series No. RR-17-39

ERIC Educational Resources Information Center

Millett, Catherine, Ed.

2017-01-01

College promise programs are spreading throughout this United States. These programs fund tuition and/or fees for eligible students who are actively progressing toward earning postsecondary certificates and undergraduate degrees. While existing college promise programs have varying designs, each one appears to be seeking continuous and long-term…

40 CFR 62.14560 - How do I comply with the increment of progress for submittal of a control plan?

Code of Federal Regulations, 2013 CFR

2013-07-01

... DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements for Commercial and Industrial Solid Waste Incineration Units That Commenced Construction On or Before November 30, 1999 Compliance Schedule and... requirements of this subpart. (2) The type(s) of waste to be burned. (3) The maximum design waste burning...

Systematic Review of Design-Based Research Progress: Is a Little Knowledge a Dangerous Thing?

ERIC Educational Resources Information Center

McKenney, Susan; Reeves, Thomas C.

2013-01-01

Sufficient attention and resources have been allocated to design-based research (DBR) to warrant review concerning if and how its potential has been realized. Because the DBR literature clearly indicates that this type of research strives toward both the development of an intervention to address a problem in practice and empirical investigation…

Experimental progress of a 4K VM/PT hybrid cryocooler for pre-cooling 1K sorption cooler

NASA Astrophysics Data System (ADS)

Pan, Changzhao; Zhang, Tong; Wang, Jue; Chen, Liubiao; Guo, Jia; Zhou, Yuan; Wang, Junjie

2017-12-01

Sub-kelvin refrigerator has many applications in space detector and manned space station, such as for the transition-edge superconducting (TES) bolometers operated in the 50 mK range. In order to meet the requirement of space applications, the high efficient, vibration free and high stability refrigerator need to be designed. VM/PT hybrid cryocooler is a new type cryocooler capable of attaining temperature below 4K. As a low frequency Stirling type cryocooler, it has the advantages of high stability and high efficiency. Combined with the vibration free sorption cooler and ADR refrigerator, a novel sub-kelvin cooling chain can be designed for the TES bolometer. This paper presents the recent experimental progress of the 4K VM/PT hybrid cryocooler in our laboratory. By optimizing of regenerators, phase shifters and heat exchangers, a lowest temperature of 2.6K was attained. Based on this cryocooler, a preliminary sorption cooler could be designed.

Recent Progress on High-Current SRF Cavities at Jlab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robert Rimmer, William Clemens, James Henry, Peter Kneisel, Kurt Macha, Frank Marhauser, Larry Turlington, Haipeng Wang, Daniel Forehand

2010-05-01

JLab has designed and fabricated several prototype SRF cavities with cell shapes optimized for high current beams and with strong damping of unwanted higher order modes. We report on the latest test results of these cavities and on developments of concepts for new variants optimized for particular applications such as light sources and high-power proton accelerators, including betas less than one. We also report on progress towards a first beam test of this design in the recirculation loop of the JLab ERL based FEL. With growing interest worldwide in applications of SRF for high-average power electron and hadron machines, amore » practical test of these concepts is highly desirable. We plan to package two prototype cavities in a de-mountable cryomodule for temporary installation into the JLab FEL for testing with RF and beam. This will allow verification of all critical design and operational parameters paving the way to a full-scale prototype cryomodule.« less

Progress of the Swedish-Australian research collaboration on uncooled smart IR sensors

NASA Astrophysics Data System (ADS)

Liddiard, Kevin C.; Ringh, Ulf; Jansson, Christer; Reinhold, Olaf

1998-10-01

Progress is reported on the development of uncooled microbolometer IR focal plane detector arrays (IRFPDA) under a research collaboration between the Swedish Defence Research Establishment (FOA), and the Defence Science and Technology Organization (DSTO), Australia. The paper describes current focal plane detector arrays designed by Electro-optic Sensor Design (EOSD) for readout circuits developed by FOA. The readouts are fabricated in 0.8 micrometer CMOS, and have a novel signal conditioning and 16 bit parallel ADC design. The arrays are post-processed at DSTO on wafers supplied by FOA. During the past year array processing has been carried out at a new microengineering facility at DSTO, Salisbury, South Australia. A number of small format 16 X 16 arrays have been delivered to FOA for evaluation, and imaging has been demonstrated with these arrays. A 320 X 240 readout with 320 parallel 16 bit ADCs has been developed and IRFPDAs for this readout have been fabricated and are currently being evaluated.

Nonlinear ship waves and computational fluid dynamics

PubMed Central

MIYATA, Hideaki; ORIHARA, Hideo; SATO, Yohei

2014-01-01

Research works undertaken in the first author’s laboratory at the University of Tokyo over the past 30 years are highlighted. Finding of the occurrence of nonlinear waves (named Free-Surface Shock Waves) in the vicinity of a ship advancing at constant speed provided the start-line for the progress of innovative technologies in the ship hull-form design. Based on these findings, a multitude of the Computational Fluid Dynamic (CFD) techniques have been developed over this period, and are highlighted in this paper. The TUMMAC code has been developed for wave problems, based on a rectangular grid system, while the WISDAM code treats both wave and viscous flow problems in the framework of a boundary-fitted grid system. These two techniques are able to cope with almost all fluid dynamical problems relating to ships, including the resistance, ship’s motion and ride-comfort issues. Consequently, the two codes have contributed significantly to the progress in the technology of ship design, and now form an integral part of the ship-designing process. PMID:25311139