Classification and determination of cerebral biovailability of psychotropic drugs by quantitative "pharmaco-EEG" and psychometric investigations (studies with AX-A411-BS).

PubMed

Saletu, B; Grünberger, J; Linzmayer, L

1977-10-01

Utilizing computerized quantitative analysis of the human scalp recorded electroencephalogram (EEG), it is possible to classify psychotropic drugs. While neuroleptic compounds produce an increase of slow and decrease of fast activities, anxiolytic substances induce an augmentation of fast waves, decrease of alpha waves and--according to the sedative properties of the drug--an increase or decrease of slow waves. Antidepressants produce a concomitant augmentation of slow and fast activities as well as an attenuation of alpha waves. Nootropic substances attenuate slow activities, augment alpha and slow beta waves and decrease fast beta waves. The latter alterations are quite opposite to age-related changes. Since the main psychopharmacological classes seem to have characteristic pharmaco-EEG profiles, the method proved to be useful for determination of psychoactivity and cerebral bioavailability of newly developed substances as for instance AX-A411-BS, a new benzodiazepine. The latter substance was found to be CNS-active and was classified as anxiolytic. It induced dosedependent changes, which were barely visible in the 2nd hour post-drug, became quite obvious in the 4th hour and increased until the 8th hour after oral administration of one single dose. In the higher dosage range, slow activities came to the fore, indicating aoditional sedative properties. Psychometric tests measuring attention, psychomotor activity. mood, vigilance, extroversion, concentration aith a long-lasting effect. The implications of these methods are discussed.

Slow-Mode MHD Wave Penetration into a Coronal Null Point due to the Mode Transmission

NASA Astrophysics Data System (ADS)

Afanasyev, Andrey N.; Uralov, Arkadiy M.

2016-11-01

Recent observations of magnetohydrodynamic oscillations and waves in solar active regions revealed their close link to quasi-periodic pulsations in flaring light curves. The nature of that link has not yet been understood in detail. In our analytical modelling we investigate propagation of slow magnetoacoustic waves in a solar active region, taking into account wave refraction and transmission of the slow magnetoacoustic mode into the fast one. The wave propagation is analysed in the geometrical acoustics approximation. Special attention is paid to the penetration of waves in the vicinity of a magnetic null point. The modelling has shown that the interaction of slow magnetoacoustic waves with the magnetic reconnection site is possible due to the mode transmission at the equipartition level where the sound speed is equal to the Alfvén speed. The efficiency of the transmission is also calculated.

Age-Dependency of Location of Epileptic Foci in "Continuous Spike-and-Waves during Sleep": A Parallel to the Posterior-Anterior Trajectory of Slow Wave Activity.

PubMed

Bölsterli Heinzle, Bigna Katrin; Bast, Thomas; Critelli, Hanne; Huber, Reto; Schmitt, Bernhard

2017-02-01

Epileptic encephalopathy with continuous spike-and-waves during sleep (CSWS) occurs during childhood and is characterized by an activation of spike wave complexes during slow wave sleep. The location of epileptic foci is variable, as is etiology. A relationship between the epileptic focus and age has been shown in various focal epilepsies following a posterior-anterior trajectory, and a link to brain maturation has been proposed. We hypothesize that in CSWS, maximal spike wave activity, corresponding to the epileptic focus, is related to age and shows a posterior-anterior evolution. In a retrospective cross-sectional study on CSWS (22 EEGs of 22 patients aged 3.1–13.5 years), the location of the epileptic focus is related to age and follows a posterior-anterior course. Younger patients are more likely to have posterior foci than older ones. We propose that the posterior-anterior trajectory of maximal spike waves in CSWS might reflect maturational changes of maximal expression of sleep slow waves, which follow a comparable course. Epileptic spike waves, that is, “hyper-synchronized slow waves” may occur at the place where the highest and therefore most synchronized slow waves meet brain tissue with an increased susceptibility to synchronization. Georg Thieme Verlag KG Stuttgart · New York.

Role of Somatostatin-Positive Cortical Interneurons in the Generation of Sleep Slow Waves.

PubMed

Funk, Chadd M; Peelman, Kayla; Bellesi, Michele; Marshall, William; Cirelli, Chiara; Tononi, Giulio

2017-09-20

During non-rapid eye-movement (NREM) sleep, cortical and thalamic neurons oscillate every second or so between ON periods, characterized by membrane depolarization and wake-like tonic firing, and OFF periods, characterized by membrane hyperpolarization and neuronal silence. Cortical slow waves, the hallmark of NREM sleep, reflect near-synchronous OFF periods in cortical neurons. However, the mechanisms triggering such OFF periods are unclear, as there is little evidence for somatic inhibition. We studied cortical inhibitory interneurons that express somatostatin (SOM), because ∼70% of them are Martinotti cells that target diffusely layer I and can block excitatory transmission presynaptically, at glutamatergic terminals, and postsynaptically, at apical dendrites, without inhibiting the soma. In freely moving male mice, we show that SOM+ cells can fire immediately before slow waves and their optogenetic stimulation during ON periods of NREM sleep triggers long OFF periods. Next, we show that chemogenetic activation of SOM+ cells increases slow-wave activity (SWA), slope of individual slow waves, and NREM sleep duration; whereas their chemogenetic inhibition decreases SWA and slow-wave incidence without changing time spent in NREM sleep. By contrast, activation of parvalbumin+ (PV+) cells, the most numerous population of cortical inhibitory neurons, greatly decreases SWA and cortical firing, triggers short OFF periods in NREM sleep, and increases NREM sleep duration. Thus SOM+ cells, but not PV+ cells, are involved in the generation of sleep slow waves. Whether Martinotti cells are solely responsible for this effect, or are complemented by other classes of inhibitory neurons, remains to be investigated. SIGNIFICANCE STATEMENT Cortical slow waves are a defining feature of non-rapid eye-movement (NREM) sleep and are thought to be important for many of its restorative benefits. Yet, the mechanism by which cortical neurons abruptly and synchronously cease firing, the neuronal basis of the slow wave, remains unknown. Using chemogenetic and optogenetic approaches, we provide the first evidence that links a specific class of inhibitory interneurons-somatostatin-positive cells-to the generation of slow waves during NREM sleep in freely moving mice. Copyright © 2017 the authors 0270-6474/17/379132-17$15.00/0.

Clustering of Ca2+ transients in interstitial cells of Cajal defines slow wave duration

PubMed Central

Drumm, Bernard T.; Hennig, Grant W.; Battersby, Matthew J.; Sung, Tae Sik

2017-01-01

Interstitial cells of Cajal (ICC) in the myenteric plexus region (ICC-MY) of the small intestine are pacemakers that generate rhythmic depolarizations known as slow waves. Slow waves depend on activation of Ca2+-activated Cl− channels (ANO1) in ICC, propagate actively within networks of ICC-MY, and conduct to smooth muscle cells where they generate action potentials and phasic contractions. Thus, mechanisms of Ca2+ regulation in ICC are fundamental to the motor patterns of the bowel. Here, we characterize the nature of Ca2+ transients in ICC-MY within intact muscles, using mice expressing a genetically encoded Ca2+ sensor, GCaMP3, in ICC. Ca2+ transients in ICC-MY display a complex firing pattern caused by localized Ca2+ release events arising from multiple sites in cell somata and processes. Ca2+ transients are clustered within the time course of slow waves but fire asynchronously during these clusters. The durations of Ca2+ transient clusters (CTCs) correspond to slow wave durations (plateau phase). Simultaneous imaging and intracellular electrical recordings revealed that the upstroke depolarization of slow waves precedes clusters of Ca2+ transients. Summation of CTCs results in relatively uniform Ca2+ responses from one slow wave to another. These Ca2+ transients are caused by Ca2+ release from intracellular stores and depend on ryanodine receptors as well as amplification from IP3 receptors. Reduced extracellular Ca2+ concentrations and T-type Ca2+ channel blockers decreased the number of firing sites and firing probability of Ca2+ transients. In summary, the fundamental electrical events of small intestinal muscles generated by ICC-MY depend on asynchronous firing of Ca2+ transients from multiple intracellular release sites. These events are organized into clusters by Ca2+ influx through T-type Ca2+ channels to sustain activation of ANO1 channels and generate the plateau phase of slow waves. PMID:28592421

Scatterplot analysis of EEG slow-wave magnitude and heart rate variability: an integrative exploration of cerebral cortical and autonomic functions.

PubMed

Kuo, Terry B J; Yang, Cheryl C H

2004-06-15

To explore interactions between cerebral cortical and autonomic functions in different sleep-wake states. Active waking (AW), quiet sleep (QS), and paradoxical sleep (PS) of adult male Wistar-Kyoto rats (WKY) on their daytime sleep were compared. Ten WKY. All rats had electrodes implanted for polygraphic recordings. One week later, a 6-hour daytime sleep-wakefulness recording session was performed. A scatterplot analysis of electroencephalogram (EEG) slow-wave magnitude (0.5-4 Hz) and heart rate variability (HRV) was applied in each rat. The EEG slow-wave-RR interval scatterplot from all of the recordings revealed a propeller-like pattern. If the scatterplot was divided into AW, PS, and QS according to the corresponding EEG mean power frequency and nuchal electromyogram, the EEG slow wave-RR interval relationship became nil, negative, and positive for AW, PS, and QS, respectively. A significant negative relationship was found for EEG slow-wave and high-frequency power of HRV (HF) coupling during PS and for EEG slow wave and low-frequency power of HRV to HF ratio (LF/HF) coupling during QS. The optimal time lags for the slow wave-LF/HF relationship were different between PS and QS. Bradycardia noted in QS and PS was related to sympathetic suppression and vagal excitation, respectively. The EEG slow wave-HRV scatterplot may provide unique insights into studies of sleep, and such a relationship may delineate the sleep-state-dependent fluctuations in autonomic nervous system activity.

How do children fall asleep? A high-density EEG study of slow waves in the transition from wake to sleep.

PubMed

Spiess, Mathilde; Bernardi, Giulio; Kurth, Salome; Ringli, Maya; Wehrle, Flavia M; Jenni, Oskar G; Huber, Reto; Siclari, Francesca

2018-05-17

Slow waves, the hallmarks of non-rapid eye-movement (NREM) sleep, are thought to reflect maturational changes that occur in the cerebral cortex throughout childhood and adolescence. Recent work in adults has revealed evidence for two distinct synchronization processes involved in the generation of slow waves, which sequentially come into play in the transition to sleep. In order to understand how these two processes are affected by developmental changes, we compared slow waves between children and young adults in the falling asleep period. The sleep onset period (starting 30s before end of alpha activity and ending at the first slow wave sequence) was extracted from 72 sleep onset high-density EEG recordings (128 electrodes) of 49 healthy subjects (age 8-25). Using an automatic slow wave detection algorithm, the number, amplitude and slope of slow waves were analyzed and compared between children (age 8-11) and young adults (age 20-25). Slow wave number and amplitude increased linearly in the falling asleep period in children, while in young adults, isolated high-amplitude slow waves (type I) dominated initially and numerous smaller slow waves (type II) with progressively increasing amplitude occurred later. Compared to young adults, children displayed faster increases in slow wave amplitude and number across the falling asleep period in central and posterior brain regions, respectively, and also showed larger slow waves during wakefulness immediately prior to sleep. Children do not display the two temporally dissociated slow wave synchronization processes in the falling asleep period observed in adults, suggesting that maturational factors underlie the temporal segregation of these two processes. Our findings provide novel perspectives for studying how sleep-related behaviors and dreaming differ between children and adults. Copyright © 2018 Elsevier Inc. All rights reserved.

SLOW MAGNETOACOUSTIC WAVES OBSERVED ABOVE A QUIET-SUN REGION IN A DARK CAVITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu Jiajia; Zhou Zhenjun; Wang Yuming

Waves play a crucial role in diagnosing the plasma properties of various structures in the solar corona and coronal heating. Slow magnetoacoustic (MA) waves are one of the important types of magnetohydrodynamic waves. In past decades, numerous slow MA waves were detected above active regions and coronal holes, but were rarely found elsewhere. Here, we investigate a 'tornado'-like structure consisting of quasi-periodic streaks within a dark cavity at about 40-110 Mm above a quiet-Sun region on 2011 September 25. Our analysis reveals that these streaks are actually slow MA wave trains. The properties of these wave trains, including phase speed,more » compression ratio, and kinetic energy density, are similar to those of the reported slow MA waves, except that the period of these waves is about 50 s, much shorter than the typical reported values (3-5 minutes).« less

Circumferential and functional re-entry of in vivo slow-wave activity in the porcine small intestine.

PubMed

Angeli, T R; O'Grady, G; Du, P; Paskaranandavadivel, N; Pullan, A J; Bissett, I P; Cheng, L K

2013-05-01

Slow-waves modulate the pattern of small intestine contractions. However, the large-scale spatial organization of intestinal slow-wave pacesetting remains uncertain because most previous studies have had limited resolution. This study applied high-resolution (HR) mapping to evaluate intestinal pacesetting mechanisms and propagation patterns in vivo. HR serosal mapping was performed in anesthetized pigs using flexible arrays (256 electrodes; 32 × 8; 4 mm spacing), applied along the jejunum. Slow-wave propagation patterns, frequencies, and velocities were calculated. Slow-wave initiation sources were identified and analyzed by animation and isochronal activation mapping. Analysis comprised 32 recordings from nine pigs (mean duration 5.1 ± 3.9 min). Slow-wave propagation was analyzed, and a total of 26 sources of slow-wave initiation were observed and classified as focal pacemakers (31%), sites of functional re-entry (23%) and circumferential re-entry (35%), or indeterminate sources (11%). The mean frequencies of circumferential and functional re-entry were similar (17.0 ± 0.3 vs 17.2 ± 0.4 cycle min(-1) ; P = 0.5), and greater than that of focal pacemakers (12.7 ± 0.8 cycle min(-1) ; P < 0.001). Velocity was anisotropic (12.9 ± 0.7 mm s(-1) circumferential vs 9.0 ± 0.7 mm s(-1) longitudinal; P < 0.05), contributing to the onset and maintenance of re-entry. This study has shown multiple patterns of slow-wave initiation in the jejunum of anesthetized pigs. These results constitute the first description and analysis of circumferential re-entry in the gastrointestinal tract and functional re-entry in the in vivo small intestine. Re-entry can control the direction, pattern, and frequency of slow-wave propagation, and its occurrence and functional significance merit further investigation. © 2013 Blackwell Publishing Ltd.

Reconstruction of gastric slow wave from finger photoplethysmographic signal using radial basis function neural network.

PubMed

Mohamed Yacin, S; Srinivasa Chakravarthy, V; Manivannan, M

2011-11-01

Extraction of extra-cardiac information from photoplethysmography (PPG) signal is a challenging research problem with significant clinical applications. In this study, radial basis function neural network (RBFNN) is used to reconstruct the gastric myoelectric activity (GMA) slow wave from finger PPG signal. Finger PPG and GMA (measured using Electrogastrogram, EGG) signals were acquired simultaneously at the sampling rate of 100 Hz from ten healthy subjects. Discrete wavelet transform (DWT) was used to extract slow wave (0-0.1953 Hz) component from the finger PPG signal; this slow wave PPG was used to reconstruct EGG. A RBFNN is trained on signals obtained from six subjects in both fasting and postprandial conditions. The trained network is tested on data obtained from the remaining four subjects. In the earlier study, we have shown the presence of GMA information in finger PPG signal using DWT and cross-correlation method. In this study, we explicitly reconstruct gastric slow wave from finger PPG signal by the proposed RBFNN-based method. It was found that the network-reconstructed slow wave provided significantly higher (P < 0.0001) correlation (≥ 0.9) with the subject's EGG slow wave than the correlation obtained (≈0.7) between the PPG slow wave from DWT and the EEG slow wave. Our results showed that a simple finger PPG signal can be used to reconstruct gastric slow wave using RBFNN method.

Effects of imatinib mesylate on spontaneous electrical and mechanical activity in smooth muscle of the guinea-pig stomach

PubMed Central

Hashitani, H; Hayase, M; Suzuki, H

2008-01-01

Background and purpose: Effects of imatinib mesylate, a Kit receptor tyrosine kinase inhibitor, on spontaneous activity of interstitial cells of Cajal (ICC) and smooth muscles in the stomach were investigated. Experimental approach: Effects of imatinib on spontaneous electrical and mechanical activity were investigated by measuring changes in the membrane potential and tension recorded from smooth muscles of the guinea-pig stomach. Its effects on spontaneous changes in intracellular concentration of Ca2+ ([Ca2+]i) (Ca2+ transients) were also examined in fura-2-loaded preparations. Key results: Imatinib (1–10 μM) suppressed spontaneous contractions and Ca2+ transients. Simultaneous recordings of electrical and mechanical activity demonstrated that imatinib (1 μM) reduced the amplitude of spontaneous contractions without suppressing corresponding slow waves. In the presence of nifedipine (1 μM), imatinib (10 μM) reduced the duration of slow waves and follower potentials in the antrum and accelerated their generation, but had little affect on their amplitude. In contrast, imatinib reduced the amplitude of antral slow potentials and slow waves in the corpus. Conclusions and implications: Imatinib may suppress spontaneous contractions of gastric smooth muscles by inhibiting pathways that increase [Ca2+]i in smooth muscles rather than by specifically inhibiting the activity of ICC. A high concentration of imatinib (10 μM) reduced the duration of slow waves or follower potentials in the antrum, which reflect activity of ICC distributed in the myenteric layers (ICC-MY), and suppressed antral slow potentials or corporal slow waves, which reflect activity of ICC within the muscle bundles (ICC-IM), presumably by inhibiting intracellular Ca2+ handling. PMID:18414381

Slow Wave Sleep Induced by GABA Agonist Tiagabine Fails to Benefit Memory Consolidation

PubMed Central

Feld, Gordon B.; Wilhelm, Ines; Ma, Ying; Groch, Sabine; Binkofski, Ferdinand; Mölle, Matthias; Born, Jan

2013-01-01

Study Objectives: Slow wave sleep (SWS) plays a pivotal role in consolidating memories. Tiagabine has been shown to increase SWS in favor of REM sleep without impacting subjective sleep. However, it is unknown whether this effect is paralleled by an improved sleep-dependent consolidation of memory. Design: This double-blind within-subject crossover study tested sensitivity of overnight retention of declarative neutral and emotional materials (word pairs, pictures) as well as a procedural memory task (sequence finger tapping) to oral administration of placebo or 10 mg tiagabine (at 22:30). Participants: Fourteen healthy young men aged 21.9 years (range 18-28 years). Measurements and Results: Tiagabine significantly increased the time spent in SWS and decreased REM sleep compared to placebo. Tiagabine also enhanced slow wave activity (0.5-4.0 Hz) and density of < 1 Hz slow oscillations during NREM sleep. Fast (12-15 Hz) and slow (9-12 Hz) spindle activity, in particular that occurring phase-locked to the slow oscillation cycle, was decreased following tiagabine. Despite signs of deeper and more SWS, overnight retention of memory tested after sleep the next evening (19:30) was generally not improved after tiagabine, but on average even lower than after placebo, with this impairing effect reaching significance for procedural sequence finger tapping. Conclusions: Our data show that increasing slow wave sleep with tiagabine does not improve memory consolidation. Possibly this is due to functional differences from normal slow wave sleep, i.e., the concurrent suppressive influence of tiagabine on phase-locked spindle activity. Citation: Feld GB; Wilhelm I; Ma Y; Groch S; Binkofski F; Mölle M; Born J. Slow wave sleep induced by GABA agonist tiagabine fails to benefit memory consolidation. SLEEP 2013;36(9):1317-1326. PMID:23997364

Effects of electric stimulation of the hunger center in the lateral hypothalamus on slow electric activity and spike activity of fundal and antral stomach muscles in rabbits under conditions of hunger and satiation.

PubMed

Kromin, A A; Zenina, O Yu

2013-09-01

In chronic experiments on rabbits, the effect of electric stimulation of the hunger center in the lateral hypothalamus on myoelectric activity of the fundal and antral parts of the stomach was studied under conditions of hunger and satiation in the absence of food. Stimulation of the lateral hypothalamus in rabbits subjected to 24-h food deprivation and in previously fed rabbits produced incessant seeking behavior, which was followed by reorganization of the structure of temporal organization of slow wave electric activity of muscles of the stomach body and antrum specific for hungry and satiated animals. Increased hunger motivation during electric stimulation of the lateral hypothalamus manifested in the structure of temporal organization of slow wave electric activity of the stomach body and antrum muscles in rabbits subjected to 24-h food deprivation in the replacement of bimodal distribution of slow wave periods to a trimodal type typical of 2-day deprivation, while transition from satiation to hunger caused by electric stimulation of the lateral hypothalamus was associated with a shift from monomodal distributions of slow wave periods to a bimodal type typical of 24-h deprivation. Reorganization of the structure of temporal organization of slow wave electric activity of the stomach body and antrum muscles during electric stimulation of the lateral hypothalamus was determined by descending inhibitory influences of food motivational excitation on activity of the myogenic pacemaker of the lesser curvature of the stomach.

Properties of slow oscillation during slow-wave sleep and anesthesia in cats.

PubMed

Chauvette, Sylvain; Crochet, Sylvain; Volgushev, Maxim; Timofeev, Igor

2011-10-19

Deep anesthesia is commonly used as a model of slow-wave sleep (SWS). Ketamine-xylazine anesthesia reproduces the main features of sleep slow oscillation: slow, large-amplitude waves in field potential, which are generated by the alternation of hyperpolarized and depolarized states of cortical neurons. However, direct quantitative comparison of field potential and membrane potential fluctuations during natural sleep and anesthesia is lacking, so it remains unclear how well the properties of sleep slow oscillation are reproduced by the ketamine-xylazine anesthesia model. Here, we used field potential and intracellular recordings in different cortical areas in the cat to directly compare properties of slow oscillation during natural sleep and ketamine-xylazine anesthesia. During SWS cortical activity showed higher power in the slow/delta (0.1-4 Hz) and spindle (8-14 Hz) frequency range, whereas under anesthesia the power in the gamma band (30-100 Hz) was higher. During anesthesia, slow waves were more rhythmic and more synchronous across the cortex. Intracellular recordings revealed that silent states were longer and the amplitude of membrane potential around transition between active and silent states was bigger under anesthesia. Slow waves were mostly uniform across cortical areas under anesthesia, but in SWS, they were most pronounced in associative and visual areas but smaller and less regular in somatosensory and motor cortices. We conclude that, although the main features of the slow oscillation in sleep and anesthesia appear similar, multiple cellular and network features are differently expressed during natural SWS compared with ketamine-xylazine anesthesia.

Improved Visualization of Gastrointestinal Slow Wave Propagation Using a Novel Wavefront-Orientation Interpolation Technique.

PubMed

Mayne, Terence P; Paskaranandavadivel, Niranchan; Erickson, Jonathan C; OGrady, Gregory; Cheng, Leo K; Angeli, Timothy R

2018-02-01

High-resolution mapping of gastrointestinal (GI) slow waves is a valuable technique for research and clinical applications. Interpretation of high-resolution GI mapping data relies on animations of slow wave propagation, but current methods remain as rudimentary, pixelated electrode activation animations. This study aimed to develop improved methods of visualizing high-resolution slow wave recordings that increases ease of interpretation. The novel method of "wavefront-orientation" interpolation was created to account for the planar movement of the slow wave wavefront, negate any need for distance calculations, remain robust in atypical wavefronts (i.e., dysrhythmias), and produce an appropriate interpolation boundary. The wavefront-orientation method determines the orthogonal wavefront direction and calculates interpolated values as the mean slow wave activation-time (AT) of the pair of linearly adjacent electrodes along that direction. Stairstep upsampling increased smoothness and clarity. Animation accuracy of 17 human high-resolution slow wave recordings (64-256 electrodes) was verified by visual comparison to the prior method showing a clear improvement in wave smoothness that enabled more accurate interpretation of propagation, as confirmed by an assessment of clinical applicability performed by eight GI clinicians. Quantitatively, the new method produced accurate interpolation values compared to experimental data (mean difference 0.02 ± 0.05 s) and was accurate when applied solely to dysrhythmic data (0.02 ± 0.06 s), both within the error in manual AT marking (mean 0.2 s). Mean interpolation processing time was 6.0 s per wave. These novel methods provide a validated visualization platform that will improve analysis of high-resolution GI mapping in research and clinical translation.

EEG slow waves in traumatic brain injury: Convergent findings in mouse and man

PubMed Central

Modarres, Mo; Kuzma, Nicholas N.; Kretzmer, Tracy; Pack, Allan I.; Lim, Miranda M.

2016-01-01

Objective Evidence from previous studies suggests that greater sleep pressure, in the form of EEG-based slow waves, accumulates in specific brain regions that are more active during prior waking experience. We sought to quantify the number and coherence of EEG slow waves in subjects with mild traumatic brain injury (mTBI). Methods We developed a method to automatically detect individual slow waves in each EEG channel, and validated this method using simulated EEG data. We then used this method to quantify EEG-based slow waves during sleep and wake states in both mouse and human subjects with mTBI. A modified coherence index that accounts for information from multiple channels was calculated as a measure of slow wave synchrony. Results Brain-injured mice showed significantly higher theta:alpha amplitude ratios and significantly more slow waves during spontaneous wakefulness and during prolonged sleep deprivation, compared to sham-injured control mice. Human subjects with mTBI showed significantly higher theta:beta amplitude ratios and significantly more EEG slow waves while awake compared to age-matched control subjects. We then quantified the global coherence index of slow waves across several EEG channels in human subjects. Individuals with mTBI showed significantly less EEG global coherence compared to control subjects while awake, but not during sleep. EEG global coherence was significantly correlated with severity of post-concussive symptoms (as assessed by the Neurobehavioral Symptom Inventory scale). Conclusion and implications Taken together, our data from both mouse and human studies suggest that EEG slow wave quantity and the global coherence index of slow waves may represent a sensitive marker for the diagnosis and prognosis of mTBI and post-concussive symptoms. PMID:28018987

EEG slow waves in traumatic brain injury: Convergent findings in mouse and man.

PubMed

Modarres, Mo; Kuzma, Nicholas N; Kretzmer, Tracy; Pack, Allan I; Lim, Miranda M

2016-07-01

Evidence from previous studies suggests that greater sleep pressure, in the form of EEG-based slow waves, accumulates in specific brain regions that are more active during prior waking experience. We sought to quantify the number and coherence of EEG slow waves in subjects with mild traumatic brain injury (mTBI). We developed a method to automatically detect individual slow waves in each EEG channel, and validated this method using simulated EEG data. We then used this method to quantify EEG-based slow waves during sleep and wake states in both mouse and human subjects with mTBI. A modified coherence index that accounts for information from multiple channels was calculated as a measure of slow wave synchrony. Brain-injured mice showed significantly higher theta:alpha amplitude ratios and significantly more slow waves during spontaneous wakefulness and during prolonged sleep deprivation, compared to sham-injured control mice. Human subjects with mTBI showed significantly higher theta:beta amplitude ratios and significantly more EEG slow waves while awake compared to age-matched control subjects. We then quantified the global coherence index of slow waves across several EEG channels in human subjects. Individuals with mTBI showed significantly less EEG global coherence compared to control subjects while awake, but not during sleep. EEG global coherence was significantly correlated with severity of post-concussive symptoms (as assessed by the Neurobehavioral Symptom Inventory scale). Taken together, our data from both mouse and human studies suggest that EEG slow wave quantity and the global coherence index of slow waves may represent a sensitive marker for the diagnosis and prognosis of mTBI and post-concussive symptoms.

Modeling resting-state functional networks when the cortex falls asleep: local and global changes.

PubMed

Deco, Gustavo; Hagmann, Patric; Hudetz, Anthony G; Tononi, Giulio

2014-12-01

The transition from wakefulness to sleep represents the most conspicuous change in behavior and the level of consciousness occurring in the healthy brain. It is accompanied by similarly conspicuous changes in neural dynamics, traditionally exemplified by the change from "desynchronized" electroencephalogram activity in wake to globally synchronized slow wave activity of early sleep. However, unit and local field recordings indicate that the transition is more gradual than it might appear: On one hand, local slow waves already appear during wake; on the other hand, slow sleep waves are only rarely global. Studies with functional magnetic resonance imaging also reveal changes in resting-state functional connectivity (FC) between wake and slow wave sleep. However, it remains unclear how resting-state networks may change during this transition period. Here, we employ large-scale modeling of the human cortico-cortical anatomical connectivity to evaluate changes in resting-state FC when the model "falls asleep" due to the progressive decrease in arousal-promoting neuromodulation. When cholinergic neuromodulation is parametrically decreased, local slow waves appear, while the overall organization of resting-state networks does not change. Furthermore, we show that these local slow waves are structured macroscopically in networks that resemble the resting-state networks. In contrast, when the neuromodulator decrease further to very low levels, slow waves become global and resting-state networks merge into a single undifferentiated, broadly synchronized network. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Propofol Anesthesia and Sleep: A High-Density EEG Study

PubMed Central

Murphy, Michael; Bruno, Marie-Aurelie; Riedner, Brady A.; Boveroux, Pierre; Noirhomme, Quentin; Landsness, Eric C.; Brichant, Jean-Francois; Phillips, Christophe; Massimini, Marcello; Laureys, Steven; Tononi, Giulio; Boly, Melanie

2011-01-01

Study Objectives: The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep. Design: 256-channel EEG recordings in humans during propofol anesthesia. Setting: Hospital operating room. Patients or Participants: 8 healthy subjects (4 males) Interventions: N/A Measurements and Results: Initially, propofol induced increases in EEG power from 12–25 Hz. Loss of consciousness (LOC) was accompanied by the appearance of EEG slow waves that resembled the slow waves of NREM sleep. We compared slow waves in propofol to slow waves recorded during natural sleep and found that both populations of waves share similar cortical origins and preferentially propagate along the mesial components of the default network. However, propofol slow waves were spatially blurred compared to sleep slow waves and failed to effectively entrain spindle activity. Propofol also caused an increase in gamma (25–40 Hz) power that persisted throughout LOC. Source modeling analysis showed that this increase in gamma power originated from the anterior and posterior cingulate cortices. During LOC, we found increased gamma functional connectivity between these regions compared to the wakefulness. Conclusions: Propofol anesthesia is a sleep-like state and slow waves are associated with diminished consciousness even in the presence of high gamma activity. Citation: Murphy M; Bruno MA; Riedner BA; Boveroux P; Noirhomme Q; Landsness EC; Brichant JF; Phillips C; Massimini M; Laureys S; Tononi G; Boly M. Propofol anesthesia and sleep: a high-density EEG study. SLEEP 2011;34(3):283-291. PMID:21358845

Effect of bowel decontamination with metronidazole and vancomycin on gastroduodenal myoelectric activity.

PubMed

Królczyk, Grzegorz; Czupryna, Antoni; Sobocki, Jacek; Nowak, Lukasz; Zurowski, Daniel; Szatyłowiczi, Jadwiga; Strus, Magdalena; Thor, Piotr J

2004-01-01

It is well recognized that prolonged antibiotic therapy leading to gut decontamination often results in side effects and may lead to colonization of gut with pathologic bacteria. Changes of a gut microflora could play a role in dysmotility of gastrointestinal tract. The aim of the study was to evaluate influence of intraluminal colon anaerobic and aerobic bacterial flora on myoelectric activity of duodenum and stomach. A myoelectric activity recordings using electrodes implanted on small bowel of the conscious rats were performed. Group I was scheduled for control recording, group II for recordings in 4th day after metronidazole (M) administration (30 mg/kg) and group III for recordings after vancomycin (V) administration (15 mg/kg) respectively. Rat's stools were cultured for confirmation of changes in colon flora composition. Recordings were previously filtered digitally with bandwidth filter 0.01-0.1 Hz and 0.1-1.0 Hz to extract gastric and duodenal slow wave respectively and than analyzed with Fast Fourier Transformation. Baseline duodenal slow wave frequency in control group revealed 0.60 +/- 0.05 Hz. M increased slow waves frequency to 0.64 +/- 0.13 Hz and V did not 0.58 +/- 0.09 Hz (p > 0.05). Slow wave dominant frequency of the stomach showed decrease of frequency from control 0.035 +/- 0.04 to 0.025 +/- 0.06 Hz after M (p < 0.05). Pretreatment with V also did not influence slow wave dominant frequency in comparison to control group (0.036 +/- 0.07 Hz, p > 0.05). Only pretreatment with M significantly decreased gastric slow wave frequency. One can speculate that M effects are related not only to gut decontamination but also directly affects ENS. We propose hypothesis that M influence on slow wave frequency may be related not only to its antimicrobial activity but to its potential neurotoxic action on intramural ENS neurons.

Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal.

PubMed

Nieuwmeyer, Florentine; Ye, Jing; Huizinga, Jan D

2006-04-01

Substance P is generally considered an excitatory neurotransmitter related to gut motor activity, although an inhibitory influence of neurokinin-1 (NK1) receptor activation on peristalsis has also been reported. With an optimized in vitro method to assess distention-induced peristalsis, our aim was to clarify the effect of NK1 receptor activation on peristaltic activity and to reveal the mechanisms by which NK1 activation alters peristalsis. Distention of the small intestine of the mouse and guinea pig induced periodic occurrence of rhythmic waves of propagating rings of circular muscle contraction, associated with slow waves and superimposed action potentials, that propelled intestinal contents aborally. Activation of NK1 receptors by Ava[l-Pro(9),N-MeLeu10] substance P(7-11) (GR 73632) and Sar(9), Met(O(2))(11) on smooth muscle cells resulted in prolongation of the activity periods and increased action potential generation occurring superimposed on the intestinal slow wave activity. Activation of NK1 receptors on interstitial cells of Cajal resulted in an increase in slow wave frequency. Slow wave amplitude increased, likely by increased cell-to-cell coupling. The NK1 antagonist (S)-1-(2-[3-(3,4-dichlorophenyl)-1-(3-isopropoxyphenylacetyl)piperidin-3-yl]ethyl)-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride (SR 140333) induced a decrease in the slow wave frequency and duration of the activity periods evoked by distention, which makes it likely that NK1 receptor activation plays a role in the normal physiological distention-induced generation of peristaltic motor patterns. In summary, NK1 receptors play a role in normal development of peristalsis and NK1 receptor activation markedly increases propulsive peristaltic contractile activity.

Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities

PubMed Central

Du, Peng; Calder, Stefan; Angeli, Timothy R.; Sathar, Shameer; Paskaranandavadivel, Niranchan; O'Grady, Gregory; Cheng, Leo K.

2018-01-01

Gastrointestinal (GI) motility is regulated in part by electrophysiological events called slow waves, which are generated by the interstitial cells of Cajal (ICC). Slow waves propagate by a process of “entrainment,” which occurs over a decreasing gradient of intrinsic frequencies in the antegrade direction across much of the GI tract. Abnormal initiation and conduction of slow waves have been demonstrated in, and linked to, a number of GI motility disorders. A range of mathematical models have been developed to study abnormal slow waves and applied to propose novel methods for non-invasive detection and therapy. This review provides a general outline of GI slow wave abnormalities and their recent classification using multi-electrode (high-resolution) mapping methods, with a particular emphasis on the spatial patterns of these abnormal activities. The recently-developed mathematical models are introduced in order of their biophysical scale from cellular to whole-organ levels. The modeling techniques, main findings from the simulations, and potential future directions arising from notable studies are discussed. PMID:29379448

Properties of slow oscillation during slow-wave sleep and anesthesia in cats

PubMed Central

Chauvette, Sylvain; Crochet, Sylvain; Volgushev, Maxim; Timofeev, Igor

2011-01-01

Deep anesthesia is commonly used as a model of slow-wave sleep (SWS). Ketamine-xylazine anesthesia reproduces the main features of sleep slow oscillation: slow, large amplitude waves in field potential, which are generated by the alternation of hyperpolarized and depolarized states of cortical neurons. However, direct quantitative comparison of field potential and membrane potential fluctuations during natural sleep and anesthesia is lacking, so it remains unclear how well the properties of sleep slow oscillation are reproduced by the ketamine-xylazine anesthesia model. Here, we used field potential and intracellular recordings in different cortical areas in the cat, to directly compare properties of slow oscillation during natural sleep and ketamine-xylazine anesthesia. During SWS cortical activity showed higher power in the slow/delta (0.1-4 Hz) and spindle (8-14 Hz) frequency range, while under anesthesia the power in the gamma band (30-100 Hz) was higher. During anesthesia, slow waves were more rhythmic and more synchronous across the cortex. Intracellular recordings revealed that silent states were longer and the amplitude of membrane potential around transition between active and silent states was bigger under anesthesia. Slow waves were largely uniform across cortical areas under anesthesia, but in SWS they were most pronounced in associative and visual areas, but smaller and less regular in somatosensory and motor cortices. We conclude that although the main features of the slow oscillation in sleep and anesthesia appear similar, multiple cellular and network features are differently expressed during natural SWS as compared to ketamine-xylazine anesthesia. PMID:22016533

Slow Magnetosonic Waves and Fast Flows in Active Region Loops

NASA Technical Reports Server (NTRS)

Ofman, L.; Wang, T. J.; Davila, J. M.

2012-01-01

Recent extreme ultraviolet spectroscopic observations indicate that slow magnetosonic waves are present in active region (AR) loops. Some of the spectral data were also interpreted as evidence of fast (approx 100-300 km/s) quasiperiodic flows. We have performed three-dimensional magnetohydrodynamic (3D MHD) modeling of a bipolar AR that contains impulsively generated waves and flows in coronal loops. The model AR is initiated with a dipole magnetic field and gravitationally stratified density, with an upflow-driven steadily or periodically in localized regions at the footpoints of magnetic loops. The resulting flows along the magnetic field lines of the AR produce higher density loops compared to the surrounding plasma by injection of material into the flux tubes and the establishment of siphon flow.We find that the impulsive onset of flows with subsonic speeds result in the excitation of damped slow magnetosonic waves that propagate along the loops and coupled nonlinearly driven fast-mode waves. The phase speed of the slow magnetosonic waves is close to the coronal sound speed. When the amplitude of the driving pulses is increased we find that slow shock-like wave trains are produced. When the upflows are driven periodically, undamped oscillations are produced with periods determined by the periodicity of the upflows. Based on the results of the 3D MHD model we suggest that the observed slow magnetosonic waves and persistent upflows may be produced by the same impulsive events at the bases of ARs.

Effects of electrical stimulation of the hunger center in the lateral hypothalamus and food reinforcement on impulse activity of the stomach in rabbits under conditions of hunger and satiation.

PubMed

Zenina, O Yu; Kromin, A A

2012-10-01

Stimulation of the lateral hypothalamus in preliminary fed animals in the presence of the food is associated with successful food-procuring behavior, accompanied by regular generation of high-amplitude slow electrical waves by muscles of the lesser curvature, body, and antrum of the stomach, which was reflected in the structure of temporal organization of slow electrical activity in the form of unimodal distribution of slow wave periods typical of satiation state. Despite increased level of food motivation caused by stimulation of the lateral hypothalamus, the additional food intake completely abolished the inhibitory effects of hunger motivation excitement on slow electrical muscle activity in the lesser curvature, body, and antrum of the stomach of satiated rabbits. Changes in slow electrical activity of the stomach muscles in rabbits deprived of food over 24 h and offered food and associated food-procuring behavior during electrical stimulation of the lateral hypothalamus have a two-phase pattern. Despite food intake during phase I of electrical stimulation, the downstream inhibitory effect of hunger motivation excitement on myogenic pacemaker of the lesser curvature of stomach abolishes the stimulating effect of food reinforcement on slow electrical muscle activity in the lesser curvature, body, and antrum of the stomach. During phase II of electrical stimulation, the food reinforcement decreases inhibitory effect of hunger motivation excitement on myogenic pacemaker of the lesser curvature that paces maximal rhythm of slow electrical waves for muscles activity in the lesser curvature, body, and antrum of the stomach, which is reflected by unimodal distribution of slow electrical wave periods. Our results indicated that the structure of temporal organization of slow electrical activity of the stomach muscles reflects convergent interactions of food motivation and reinforcement excitations on the dorsal vagal complex neurons in medulla oblongata.

Vagus Nerve Stimulation for Electrographic Status Epilepticus in Slow-Wave Sleep.

PubMed

Carosella, Christopher M; Greiner, Hansel M; Byars, Anna W; Arthur, Todd M; Leach, James L; Turner, Michele; Holland, Katherine D; Mangano, Francesco T; Arya, Ravindra

2016-07-01

Electrographic status epilepticus in slow sleep or continuous spike and waves during slow-wave sleep is an epileptic encephalopathy characterized by seizures, neurocognitive regression, and significant activation of epileptiform discharges during nonrapid eye movement sleep. There is no consensus on the diagnostic criteria and evidence-based optimal treatment algorithm for children with electrographic status epilepticus in slow sleep. We describe a 12-year-old girl with drug-resistant electrographic status epilepticus in slow wave sleep that was successfully treated with vagus nerve stimulation. Her clinical presentation, presurgical evaluation, decision-making, and course after vagus nerve stimulator implantation are described in detail. After vagus nerve stimulator implantation, the girl remained seizure free for more than a year, resolved the electrographic status epilepticus in slow sleep pattern on electroencephalography, and exhibited significant cognitive improvement. Vagus nerve stimulation may be considered for electrographic status epilepticus in slow sleep. Copyright © 2016 Elsevier Inc. All rights reserved.

A theoretical analysis of anatomical and functional intestinal slow wave re-entry.

PubMed

Du, Peng; O'Grady, Gregory; Cheng, Leo K

2017-07-21

Intestinal bioelectrical slow waves are a key regulator of intestinal motility. Peripheral pacemakers, ectopic initiations and sustained periods of re-entrant activities have all been experimentally observed to be important factors in setting the frequency of intestinal slow waves, but the tissue-level mechanisms underpinning these activities are unclear. This theoretical analysis aimed to define the initiation, maintenance, and termination criteria of two classes of intestinal re-entrant activities: anatomical re-entry and functional re-entry. Anatomical re-entry was modeled in a three-dimensional (3D) cylindrical model, and functional rotor was modeled in a 2D rectangle model. A single-pulse stimulus was used to invoke an anatomical re-entry and a prolonged refractory block was used to invoke the rotor. In both cases, the simulated re-entrant activities operated at frequencies above the baseline entrainment frequency. The anatomical re-entry simulation results demonstrated that a temporary functional refractory block would be required to initiate the re-entrant activity in a single direction around the cylindrical model. The rotor could be terminated by a single-pulse stimulus delivered around the core of the rotor. In conclusion, the simulation results provide the following new insights into the mechanisms of intestinal re-entry: (i) anatomical re-entry is only maintained within a specific range of velocities, outside of which the re-entrant activities become either an ectopic activity or simultaneous activations of the intestinal wall; (ii) a maintained rotor entrained slow waves faster in the antegrade direction than in the retrograde direction. Simulations are shown to be a valuable tool for achieving novel insights into the mechanisms of intestinal slow wave dysrhythmia. Copyright © 2017 Elsevier Ltd. All rights reserved.

Resting-state slow wave power, healthy aging and cognitive performance.

PubMed

Vlahou, Eleni L; Thurm, Franka; Kolassa, Iris-Tatjana; Schlee, Winfried

2014-05-29

Cognitive functions and spontaneous neural activity show significant changes over the life-span, but the interrelations between age, cognition and resting-state brain oscillations are not well understood. Here, we assessed performance on the Trail Making Test and resting-state magnetoencephalographic (MEG) recordings from 53 healthy adults (18-89 years old) to investigate associations between age-dependent changes in spontaneous oscillatory activity and cognitive performance. Results show that healthy aging is accompanied by a marked and linear decrease of resting-state activity in the slow frequency range (0.5-6.5 Hz). The effects of slow wave power on cognitive performance were expressed as interactions with age: For older (>54 years), but not younger participants, enhanced delta and theta power in temporal and central regions was positively associated with perceptual speed and executive functioning. Consistent with previous work, these findings substantiate further the important role of slow wave oscillations in neurocognitive function during healthy aging.

The sleep slow oscillation as a traveling wave.

PubMed

Massimini, Marcello; Huber, Reto; Ferrarelli, Fabio; Hill, Sean; Tononi, Giulio

2004-08-04

During much of sleep, virtually all cortical neurons undergo a slow oscillation (<1 Hz) in membrane potential, cycling from a hyperpolarized state of silence to a depolarized state of intense firing. This slow oscillation is the fundamental cellular phenomenon that organizes other sleep rhythms such as spindles and slow waves. Using high-density electroencephalogram recordings in humans, we show here that each cycle of the slow oscillation is a traveling wave. Each wave originates at a definite site and travels over the scalp at an estimated speed of 1.2-7.0 m/sec. Waves originate more frequently in prefrontal-orbitofrontal regions and propagate in an anteroposterior direction. Their rate of occurrence increases progressively reaching almost once per second as sleep deepens. The pattern of origin and propagation of sleep slow oscillations is reproducible across nights and subjects and provides a blueprint of cortical excitability and connectivity. The orderly propagation of correlated activity along connected pathways may play a role in spike timing-dependent synaptic plasticity during sleep.

Phase-Locked Loop for Precisely Timed Acoustic Stimulation during Sleep

PubMed Central

Santostasi, Giovanni; Malkani, Roneil; Riedner, Brady; Bellesi, Michele; Tononi, Giulio; Paller, Ken A.; Zee, Phyllis C.

2016-01-01

Background A Brain-Computer Interface could potentially enhance the various benefits of sleep. New Method We describe a strategy for enhancing slow-wave sleep (SWS) by stimulating the sleeping brain with periodic acoustic stimuli that produce resonance in the form of enhanced slow-wave activity in the electroencephalogram (EEG). The system delivers each acoustic stimulus at a particular phase of an electrophysiological rhythm using a Phase-Locked Loop (PLL). Results The PLL is computationally economical and well suited to follow and predict the temporal behavior of the EEG during slow-wave sleep. Comparison with Existing Methods Acoustic stimulation methods may be able to enhance SWS without the risks inherent in electrical stimulation or pharmacological methods. The PLL method differs from other acoustic stimulation methods that are based on detecting a single slow wave rather than modeling slow-wave activity over an extended period of time. Conclusions By providing real-time estimates of the phase of ongoing EEG oscillations, the PLL can rapidly adjust to physiological changes, thus opening up new possibilities to study brain dynamics during sleep. Future application of these methods hold promise for enhancing sleep quality and associated daytime behavior and improving physiologic function. PMID:26617321

A system and method for online high-resolution mapping of gastric slow-wave activity.

PubMed

Bull, Simon H; O'Grady, Gregory; Du, Peng; Cheng, Leo K

2014-11-01

High-resolution (HR) mapping employs multielectrode arrays to achieve spatially detailed analyses of propagating bioelectrical events. A major current limitation is that spatial analyses must currently be performed "off-line" (after experiments), compromising timely recording feedback and restricting experimental interventions. These problems motivated development of a system and method for "online" HR mapping. HR gastric recordings were acquired and streamed to a novel software client. Algorithms were devised to filter data, identify slow-wave events, eliminate corrupt channels, and cluster activation events. A graphical user interface animated data and plotted electrograms and maps. Results were compared against off-line methods. The online system analyzed 256-channel serosal recordings with no unexpected system terminations with a mean delay 18 s. Activation time marking sensitivity was 0.92; positive predictive value was 0.93. Abnormal slow-wave patterns including conduction blocks, ectopic pacemaking, and colliding wave fronts were reliably identified. Compared to traditional analysis methods, online mapping had comparable results with equivalent coverage of 90% of electrodes, average RMS errors of less than 1 s, and CC of activation maps of 0.99. Accurate slow-wave mapping was achieved in near real-time, enabling monitoring of recording quality and experimental interventions targeted to dysrhythmic onset. This work also advances the translation of HR mapping toward real-time clinical application.

Characterization of electrophysiological propagation by multichannel sensors

PubMed Central

Bradshaw, L. Alan; Kim, Juliana H.; Somarajan, Suseela; Richards, William O.; Cheng, Leo K.

2016-01-01

Objective The propagation of electrophysiological activity measured by multichannel devices could have significant clinical implications. Gastric slow waves normally propagate along longitudinal paths that are evident in recordings of serosal potentials and transcutaneous magnetic fields. We employed a realistic model of gastric slow wave activity to simulate the transabdominal magnetogastrogram (MGG) recorded in a multichannel biomagnetometer and to determine characteristics of electrophysiological propagation from MGG measurements. Methods Using MGG simulations of slow wave sources in a realistic abdomen (both superficial and deep sources) and in a horizontally-layered volume conductor, we compared two analytic methods (Second Order Blind Identification, SOBI and Surface Current Density, SCD) that allow quantitative characterization of slow wave propagation. We also evaluated the performance of the methods with simulated experimental noise. The methods were also validated in an experimental animal model. Results Mean square errors in position estimates were within 2 cm of the correct position, and average propagation velocities within 2 mm/s of the actual velocities. SOBI propagation analysis outperformed the SCD method for dipoles in the superficial and horizontal layer models with and without additive noise. The SCD method gave better estimates for deep sources, but did not handle additive noise as well as SOBI. Conclusion SOBI-MGG and SCD-MGG were used to quantify slow wave propagation in a realistic abdomen model of gastric electrical activity. Significance These methods could be generalized to any propagating electrophysiological activity detected by multichannel sensor arrays. PMID:26595907

Initiation of sleep-dependent cortical-hippocampal correlations at wakefulness-sleep transition.

PubMed

Haggerty, Daniel C; Ji, Daoyun

2014-10-01

Sleep is involved in memory consolidation. Current theories propose that sleep-dependent memory consolidation requires active communication between the hippocampus and neocortex. Indeed, it is known that neuronal activities in the hippocampus and various neocortical areas are correlated during slow-wave sleep. However, transitioning from wakefulness to slow-wave sleep is a gradual process. How the hippocampal-cortical correlation is established during the wakefulness-sleep transition is unknown. By examining local field potentials and multiunit activities in the rat hippocampus and visual cortex, we show that the wakefulness-sleep transition is characterized by sharp-wave ripple events in the hippocampus and high-voltage spike-wave events in the cortex, both of which are accompanied by highly synchronized multiunit activities in the corresponding area. Hippocampal ripple events occur earlier than the cortical high-voltage spike-wave events, and hippocampal ripple incidence is attenuated by the onset of cortical high-voltage spike waves. This attenuation leads to a temporary weak correlation in the hippocampal-cortical multiunit activities, which eventually evolves to a strong correlation as the brain enters slow-wave sleep. The results suggest that the hippocampal-cortical correlation is established through a concerted, two-step state change that first synchronizes the neuronal firing within each brain area and then couples the synchronized activities between the two regions. Copyright © 2014 the American Physiological Society.

Effect of acute gastric dilatation on gastric myoelectic and motor activity in dogs.

PubMed

Hall, J A; Solie, T N; Seim, H B; Twedt, D C

1999-05-01

To investigate the effects of experimentally induced acute gastric dilatation on electrical and mechanical activities of the stomach in dogs. 7 healthy dogs. Electrodes and strain-gauge force transducers were implanted on the serosal surface of the antrum and pylorus. Eight days later, baseline gastric electrical and contractile activities were recorded. The dogs were anesthetized and mechanically ventilated to maintain normocapnia while the stomach was distended (intragastric pressure, 30 mm Hg) for 180 minutes, using a thin compliant bag. Gastric electrical and contractile activities were recorded again on days 1 and 10 after dilatation. Recordings were analyzed to determine gastric slow-wave frequency, slow-wave dysrhythmia, propagation velocity of slow-waves, coupling of contractions to slow waves, motility index on the basis of relative contractile amplitudes, and onset of contractions after a standardized meal. Electrical or contractile activities were not significantly different 18 hours after acute gastric dilatation (day 1). Arrhythmias were evident before and after gastric dilatation in dogs from which food was withheld and in dogs after consumption of a meal. Variables for assessing gastric electrical and contractile activities were unaffected 18 hours after acute gastric dilatation. Analysis of results of this study indicated that altered electrical and contractile activities in dogs with short-term gastric dilatation are not likely to be secondary to the process of acute gastric dilatation.

A System and Method for Online High-Resolution Mapping of Gastric Slow-Wave Activity

PubMed Central

Bull, Simon H.; O’Grady, Gregory; Du, Peng

2015-01-01

High-resolution (HR) mapping employs multielectrode arrays to achieve spatially detailed analyses of propagating bioelectrical events. A major current limitation is that spatial analyses must currently be performed “off-line” (after experiments), compromising timely recording feedback and restricting experimental interventions. These problems motivated development of a system and method for “online” HR mapping. HR gastric recordings were acquired and streamed to a novel software client. Algorithms were devised to filter data, identify slow-wave events, eliminate corrupt channels, and cluster activation events. A graphical user interface animated data and plotted electrograms and maps. Results were compared against off-line methods. The online system analyzed 256-channel serosal recordings with no unexpected system terminations with a mean delay 18 s. Activation time marking sensitivity was 0.92; positive predictive value was 0.93. Abnormal slow-wave patterns including conduction blocks, ectopic pacemaking, and colliding wave fronts were reliably identified. Compared to traditional analysis methods, online mapping had comparable results with equivalent coverage of 90% of electrodes, average RMS errors of less than 1 s, and CC of activation maps of 0.99. Accurate slow-wave mapping was achieved in near real-time, enabling monitoring of recording quality and experimental interventions targeted to dysrhythmic onset. This work also advances the translation of HR mapping toward real-time clinical application. PMID:24860024

Beta EEG reflects sensory processing in active wakefulness and homeostatic sleep drive in quiet wakefulness.

PubMed

Grønli, Janne; Rempe, Michael J; Clegern, William C; Schmidt, Michelle; Wisor, Jonathan P

2016-06-01

Markers of sleep drive (<10 Hz; slow-wave activity and theta) have been identified in the course of slow-wave sleep and wakefulness. So far, higher frequencies in the waking electroencephalogram have not been examined thoroughly as a function of sleep drive. Here, electroencephalogram dynamics were measured in epochs of active wake (wake characterized by high muscle tone) or quiet wake (wake characterized by low muscle tone). It was hypothesized that the higher beta oscillations (15-35 Hz, measured by local field potential and electroencephalography) represent fundamentally different processes in active wake and quiet wake. In active wake, sensory stimulation elevated beta activity in parallel with gamma (80-90 Hz) activity, indicative of cognitive processing. In quiet wake, beta activity paralleled slow-wave activity (1-4 Hz) and theta (5-8 Hz) in tracking sleep need. Cerebral lactate concentration, a measure of cerebral glucose utilization, increased during active wake whereas it declined during quiet wake. Mathematical modelling of state-dependent dynamics of cortical lactate concentration was more precisely predictive when quiet wake and active wake were included as two distinct substates rather than a uniform state of wakefulness. The extent to which lactate concentration declined in quiet wake and increased in active wake was proportionate to the amount of beta activity. These data distinguish quiet wake from active wake. Quiet wake, particularly when characterized by beta activity, is permissive to metabolic and electrophysiological changes that occur in slow-wave sleep. These data urge further studies on state-dependent beta oscillations across species. © 2016 European Sleep Research Society.

Moderate Cortical Cooling Eliminates Thalamocortical Silent States during Slow Oscillation.

PubMed

Sheroziya, Maxim; Timofeev, Igor

2015-09-23

Reduction in temperature depolarizes neurons by a partial closure of potassium channels but decreases the vesicle release probability within synapses. Compared with cooling, neuromodulators produce qualitatively similar effects on intrinsic neuronal properties and synapses in the cortex. We used this similarity of neuronal action in ketamine-xylazine-anesthetized mice and non-anesthetized mice to manipulate the thalamocortical activity. We recorded cortical electroencephalogram/local field potential (LFP) activity and intracellular activities from the somatosensory thalamus in control conditions, during cortical cooling and on rewarming. In the deeply anesthetized mice, moderate cortical cooling was characterized by reversible disruption of the thalamocortical slow-wave pattern rhythmicity and the appearance of fast LFP spikes, with frequencies ranging from 6 to 9 Hz. These LFP spikes were correlated with the rhythmic IPSP activities recorded within the thalamic ventral posterior medial neurons and with depolarizing events in the posterior nucleus neurons. Similar cooling of the cortex during light anesthesia rapidly and reversibly eliminated thalamocortical silent states and evoked thalamocortical persistent activity; conversely, mild heating increased thalamocortical slow-wave rhythmicity. In the non-anesthetized head-restrained mice, cooling also prevented the generation of thalamocortical silent states. We conclude that moderate cortical cooling might be used to manipulate slow-wave network activity and induce neuromodulator-independent transition to activated states. Significance statement: In this study, we demonstrate that moderate local cortical cooling of lightly anesthetized or naturally sleeping mice disrupts thalamocortical slow oscillation and induces the activated local field potential pattern. Mild heating has the opposite effect; it increases the rhythmicity of thalamocortical slow oscillation. Our results demonstrate that slow oscillation can be influenced by manipulations to the properties of cortical neurons without changes in neuromodulation. Copyright © 2015 the authors 0270-6474/15/3513006-14$15.00/0.

Reduced Sodium Current in the Lateral Ventricular Wall Induces Inferolateral J-Waves.

PubMed

Meijborg, Veronique M F; Potse, Mark; Conrath, Chantal E; Belterman, Charly N W; De Bakker, Jacques M T; Coronel, Ruben

2016-01-01

J-waves in inferolateral leads are associated with a higher risk for idiopathic ventricular fibrillation. We aimed to test potential mechanisms (depolarization or repolarization dependent) responsible for inferolateral J-waves. We hypothesized that inferolateral J-waves can be caused by regional delayed activation of myocardium that is activated late during normal conditions. Computer simulations were performed to evaluate how J-point elevation is influenced by reducing sodium current conductivity (GNa), increasing transient outward current conductivity (Gto), or cellular uncoupling in three predefined ventricular regions (lateral, anterior, or septal). Two pig hearts were Langendorff-perfused with selective perfusion with a sodium channel blocker of lateral or anterior/septal regions. Volume-conducted pseudo-electrocardiograms (ECG) were recorded to detect the presence of J-waves. Epicardial unipolar electrograms were simultaneously recorded to obtain activation times (AT). Simulation data showed that conduction slowing, caused by reduced sodium current, in lateral, but not in other regions induced inferolateral J-waves. An increase in transient outward potassium current or cellular uncoupling in the lateral zone elicited slight J-point elevations which did not meet J-wave criteria. Additional conduction slowing in the entire heart attenuated J-waves and J-point elevations on the ECG, because of masking by the QRS. Experimental data confirmed that conduction slowing attributed to sodium channel blockade in the left lateral but not in the anterior/septal ventricular region induced inferolateral J-waves. J-waves coincided with the delayed activation. Reduced sodium current in the left lateral ventricular myocardium can cause inferolateral J-waves on the ECG.

Effect of Local Thermal Equilibrium Misbalance on Long-wavelength Slow Magnetoacoustic Waves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nakariakov, V. M.; Afanasyev, A. N.; Kumar, S.

Evolution of slow magnetoacoustic waves guided by a cylindrical magnetic flux tube that represents a coronal loop or plume, is modeled accounting for the effects of finite gas pressure, weak nonlinearity, dissipation by thermal conduction and viscosity, and the misbalance between the cooling by optically thin radiation and unspecified heating of the plasma. An evolutionary equation of the Burgers–Malthus type is derived. It is shown that the cooling/heating misbalance, determined by the derivatives of the combined radiative cooling and heating function, with respect to the density, temperature, and magnetic field at the thermal equilibrium affect the wave rather strongly. Thismore » effect may either cause additional damping, or counteract it, or lead to the gradual amplification of the wave. In the latter case, the coronal plasma acts as an active medium for the slow magnetoacoustic waves. The effect of the cooling/heating misbalance could be important for coronal slow waves, and could be responsible for certain discrepancies between theoretical results and observations, in particular, the increased or decreased damping lengths and times, detection of the waves at certain heights only, and excitation of compressive oscillations. The results obtained open up a possibility for the diagnostics of the coronal heating function by slow magnetoacoustic waves.« less

Slow oscillating transcranial direct current stimulation during sleep has a sleep-stabilizing effect in chronic insomnia: a pilot study.

PubMed

Saebipour, Mohammad R; Joghataei, Mohammad T; Yoonessi, Ali; Sadeghniiat-Haghighi, Khosro; Khalighinejad, Nima; Khademi, Soroush

2015-10-01

Recent evidence suggests that lack of slow-wave activity may play a fundamental role in the pathogenesis of insomnia. Pharmacological approaches and brain stimulation techniques have recently offered solutions for increasing slow-wave activity during sleep. We used slow (0.75 Hz) oscillatory transcranial direct current stimulation during stage 2 of non-rapid eye movement sleeping insomnia patients for resonating their brain waves to the frequency of sleep slow-wave. Six patients diagnosed with either sleep maintenance or non-restorative sleep insomnia entered the study. After 1 night of adaptation and 1 night of baseline polysomnography, patients randomly received sham or real stimulation on the third and fourth night of the experiment. Our preliminary results show that after termination of stimulations (sham or real), slow oscillatory transcranial direct current stimulation increased the duration of stage 3 of non-rapid eye movement sleep by 33 ± 26 min (P = 0.026), and decreased stage 1 of non-rapid eye movement sleep duration by 22 ± 17.7 min (P = 0.028), compared with sham. Slow oscillatory transcranial direct current stimulation decreased stage 1 of non-rapid eye movement sleep and wake time after sleep-onset durations, together, by 55.4 ± 51 min (P = 0.045). Slow oscillatory transcranial direct current stimulation also increased sleep efficiency by 9 ± 7% (P = 0.026), and probability of transition from stage 2 to stage 3 of non-rapid eye movement sleep by 20 ± 17.8% (P = 0.04). Meanwhile, slow oscillatory transcranial direct current stimulation decreased transitions from stage 2 of non-rapid eye movement sleep to wake by 12 ± 6.7% (P = 0.007). Our preliminary results suggest a sleep-stabilizing role for the intervention, which may mimic the effect of sleep slow-wave-enhancing drugs. © 2015 European Sleep Research Society.

Role of biological membranes in slow-wave sleep.

PubMed

Karnovsky, M L

1991-02-01

Two involvements of cellular membranes in slow-wave sleep (SWS) are discussed. In the first the endoplasmic reticulum (ER) is focussed upon, and in the second, the plasmalemma, where specific binding sites (receptors?) for promoters of slow-wave sleep are believed to be located. The study concerning the ER focuses on an enzyme in the brain, glucose-6-phosphatase, which, although present at low levels, manifests greatly increased activity during SWS compared to the waking state. The work on the plasmalemma has to do with the specific binding of muramyl peptides, inducers of slow-wave sleep, to various cells, and membrane preparations of various sorts, including those from brain tissue. Such cells as macrophages from mice, B-lymphocytes from human blood, and cells from a cell line (C-6 glioma) have been examined in this context.

The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation.

PubMed

Miyamoto, Daisuke; Hirai, Daichi; Murayama, Masanori

2017-01-01

Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5-4 Hz) are closely associated with memory consolidation. For example, slow-wave power is regulated in an experience-dependent manner and correlates with acquired memory. Furthermore, manipulating slow waves can enhance or impair memory consolidation. During slow wave sleep, inter-areal interactions between the cortex and hippocampus (HC) have been proposed to consolidate declarative memory; however, interactions for non-declarative (HC-independent) memory remain largely uninvestigated. We recently showed that the directional influence in a slow-wave range through a top-down cortical long-range circuit is involved in the consolidation of non-declarative memory. At the synaptic level, the average cortical synaptic strength is known to be potentiated during wakefulness and depressed during sleep. Moreover, learning causes plasticity in a subset of synapses, allocating memory to them. Sleep may help to differentiate synaptic strength between allocated and non-allocated synapses (i.e., improving the signal-to-noise ratio, which may facilitate memory consolidation). Herein, we offer perspectives on inter-areal interactions and synaptic plasticity for memory consolidation during sleep.

The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation

PubMed Central

Miyamoto, Daisuke; Hirai, Daichi; Murayama, Masanori

2017-01-01

Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5–4 Hz) are closely associated with memory consolidation. For example, slow-wave power is regulated in an experience-dependent manner and correlates with acquired memory. Furthermore, manipulating slow waves can enhance or impair memory consolidation. During slow wave sleep, inter-areal interactions between the cortex and hippocampus (HC) have been proposed to consolidate declarative memory; however, interactions for non-declarative (HC-independent) memory remain largely uninvestigated. We recently showed that the directional influence in a slow-wave range through a top-down cortical long-range circuit is involved in the consolidation of non-declarative memory. At the synaptic level, the average cortical synaptic strength is known to be potentiated during wakefulness and depressed during sleep. Moreover, learning causes plasticity in a subset of synapses, allocating memory to them. Sleep may help to differentiate synaptic strength between allocated and non-allocated synapses (i.e., improving the signal-to-noise ratio, which may facilitate memory consolidation). Herein, we offer perspectives on inter-areal interactions and synaptic plasticity for memory consolidation during sleep. PMID:29213231

A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry.

PubMed

Du, Peng; Paskaranandavadivel, Niranchan; O'Grady, Greg; Tang, Shou-Jiang; Cheng, Leo K

2015-12-01

Gastric slow wave dysrhythmias are associated with motility disorders. Periods of tachygastria associated with slow wave re-entry were recently recognized as one important dysrhythmia mechanism, but factors promoting and sustaining gastric re-entry are currently unknown. This study reports two experimental forms of gastric re-entry and presents a series of multi-scale models that define criteria for slow wave re-entry initiation, maintenance and termination. High-resolution electrical mapping was conducted in porcine and canine models and two spatiotemporal patterns of re-entrant activities were captured: single-loop rotor and double-loop figure-of-eight. Two separate multi-scale mathematical models were developed to reproduce the velocity and entrainment frequency of these experimental recordings. A single-pulse stimulus was used to invoke a rotor re-entry in the porcine model and a figure-of-eight re-entry in the canine model. In both cases, the simulated re-entrant activities were found to be perpetuated by tachygastria that was accompanied by a reduction in the propagation velocity in the re-entrant pathways. The simulated re-entrant activities were terminated by a single-pulse stimulus targeted at the tip of re-entrant wave, after which normal antegrade propagation was restored by the underlying intrinsic frequency gradient. (i) the stability of re-entry is regulated by stimulus timing, intrinsic frequency gradient and conductivity; (ii) tachygastria due to re-entry increases the frequency gradient while showing decreased propagation velocity; (iii) re-entry may be effectively terminated by a targeted stimulus at the core, allowing the intrinsic slow wave conduction system to re-establish itself. © The authors 2014. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry

PubMed Central

Du, Peng; Paskaranandavadivel, Niranchan; O’Grady, Greg; Tang, Shou-Jiang; Cheng, Leo K.

2015-01-01

Gastric slow wave dysrhythmias are associated with motility disorders. Periods of tachygastria associated with slow wave re-entry were recently recognized as one important dysrhythmia mechanism, but factors promoting and sustaining gastric re-entry are currently unknown. This study reports two experimental forms of gastric re-entry and presents a series of multi-scale models that define criteria for slow wave re-entry initiation, maintenance and termination. High-resolution electrical mapping was conducted in porcine and canine models and two spatiotemporal patterns of re-entrant activities were captured: single-loop rotor and double-loop figure-of-eight. Two separate multi-scale mathematical models were developed to reproduce the velocity and entrainment frequency of these experimental recordings. A single-pulse stimulus was used to invoke a rotor re-entry in the porcine model and a figure-of-eight re-entry in the canine model. In both cases, the simulated re-entrant activities were found to be perpetuated by tachygastria that was accompanied by a reduction in the propagation velocity in the re-entrant pathways. The simulated re-entrant activities were terminated by a single-pulse stimulus targeted at the tip of re-entrant wave, after which normal antegrade propagation was restored by the underlying intrinsic frequency gradient. Main findings: (i) the stability of re-entry is regulated by stimulus timing, intrinsic frequency gradient and conductivity; (ii) tachygastria due to re-entry increases the frequency gradient while showing decreased propagation velocity; (iii) re-entry may be effectively terminated by a targeted stimulus at the core, allowing the intrinsic slow wave conduction system to re-establish itself. PMID:25552487

Are Slow Waves of Intracranial Pressure Suppressed by General Anaesthesia?

PubMed

Lalou, Despina Afroditi; Czosnyka, Marek; Donnelly, Joseph; Lavinio, Andrea; Pickard, John D; Garnett, Matthew; Czosnyka, Zofia

2018-01-01

Slow waves of intracranial pressure (ICP) are spontaneous oscillations with a frequency of 0.3-4 cycles/min. They are often associated with pathological conditions, following vasomotor activity in the cranial enclosure. This study quantifies the effects of general anaesthesia (GA) on the magnitude of B-waves compared with natural sleep and the conscious state. Four groups of 30 patients each were formed to assess the magnitude of slow waves. Group A and group B consisted of normal pressure hydrocephalus (NPH) patients, each undergoing cerebrospinal fluid (CSF) infusion studies, conscious and under GA respectively. Group C comprised conscious, naturally asleep hydrocephalic patients undergoing overnight ICP monitoring; group D, which included deeply sedated head injury patients monitored in the intensive care unit (ICU), was compared with group C. The average amplitude for group A patients was higher (0.23 ± 0.10 mmHg) than that of group B (0.15 ± 0.10 mmHg; p = 0.01). Overnight magnitude of slow waves was higher in group C (0.20 ± 0.13 mmHg) than in group D (0.11 ± 0.09 mmHg; p = 0.002). Slow waves of ICP are suppressed by GA and deep sedation. When using slow waves in clinical decision-making, it is important to consider the patients' level of consciousness to avoid incorrect therapeutic and management decisions.

Overnight changes in the slope of sleep slow waves during infancy.

PubMed

Fattinger, Sara; Jenni, Oskar G; Schmitt, Bernhard; Achermann, Peter; Huber, Reto

2014-02-01

Slow wave activity (SWA, 0.5-4.5 Hz) is a well-established marker for sleep pressure in adults. Recent studies have shown that increasing sleep pressure is reflected by an increased synchronized firing pattern of cortical neurons, which can be measured by the slope of sleep slow waves. Thus we aimed at investigating whether the slope of sleep slow waves might provide an alternative marker to study the homeostatic regulation of sleep during early human development. All-night sleep electroencephalography (EEG) was recorded longitudinally at 2, 4, 6, and 9 months after birth. Home recording. 11 healthy full-term infants (5 male, 6 female). None. The slope of sleep slow waves increased with age. At all ages the slope decreased from the first to the last hour of non rapid-eye-movement (NREM) sleep, even when controlling for amplitude differences (P < 0.002). The decrease of the slope was also present in the cycle-by-cycle time course across the night (P < 0.001) at the age of 6 months when the alternating pattern of low-delta activity (0.75-1.75 Hz) is most prominent. Moreover, we found distinct topographical differences exhibiting the steepest slope over the occipital cortex. The results suggest an age-dependent increase in synchronization of cortical activity during infancy, which might be due to increasing synaptogenesis. Previous studies have shown that during early postnatal development synaptogenesis is most pronounced over the occipital cortex, which could explain why the steepest slope was found in the occipital derivation. Our results provide evidence that the homeostatic regulation of sleep develops early in human infants.

High-resolution electrical mapping of porcine gastric slow-wave propagation from the mucosal surface.

PubMed

Angeli, T R; Du, P; Paskaranandavadivel, N; Sathar, S; Hall, A; Asirvatham, S J; Farrugia, G; Windsor, J A; Cheng, L K; O'Grady, G

2017-05-01

Gastric motility is coordinated by bioelectrical slow waves, and gastric dysrhythmias are reported in motility disorders. High-resolution (HR) mapping has advanced the accurate assessment of gastric dysrhythmias, offering promise as a diagnostic technique. However, HR mapping has been restricted to invasive surgical serosal access. This study investigates the feasibility of HR mapping from the gastric mucosal surface. Experiments were conducted in vivo in 14 weaner pigs. Reference serosal recordings were performed with flexible-printed-circuit (FPC) arrays (128-192 electrodes). Mucosal recordings were performed by two methods: (i) FPC array aligned directly opposite the serosal array, and (ii) cardiac mapping catheter modified for gastric mucosal recordings. Slow-wave propagation and morphology characteristics were quantified and compared between simultaneous serosal and mucosal recordings. Slow-wave activity was consistently recorded from the mucosal surface from both electrode arrays. Mucosally recorded slow-wave propagation was consistent with reference serosal activation pattern, frequency (P≥.3), and velocity (P≥.4). However, mucosally recorded slow-wave morphology exhibited reduced amplitude (65-72% reduced, P<.001) and wider downstroke width (18-31% wider, P≤.02), compared to serosal data. Dysrhythmias were successfully mapped and classified from the mucosal surface, accorded with serosal data, and were consistent with known dysrhythmic mechanisms in the porcine model. High-resolution gastric electrical mapping was achieved from the mucosal surface, and demonstrated consistent propagation characteristics with serosal data. However, mucosal signal morphology was attenuated, demonstrating necessity for optimized electrode designs and analytical algorithms. This study demonstrates feasibility of endoscopic HR mapping, providing a foundation for advancement of minimally invasive spatiotemporal gastric mapping as a clinical and scientific tool. © 2016 John Wiley & Sons Ltd.

Desynchronization of slow oscillations in the basal ganglia during natural sleep.

PubMed

Mizrahi-Kliger, Aviv D; Kaplan, Alexander; Israel, Zvi; Bergman, Hagai

2018-05-01

Slow oscillations of neuronal activity alternating between firing and silence are a hallmark of slow-wave sleep (SWS). These oscillations reflect the default activity present in all mammalian species, and are ubiquitous to anesthesia, brain slice preparations, and neuronal cultures. In all these cases, neuronal firing is highly synchronous within local circuits, suggesting that oscillation-synchronization coupling may be a governing principle of sleep physiology regardless of anatomical connectivity. To investigate whether this principle applies to overall brain organization, we recorded the activity of individual neurons from basal ganglia (BG) structures and the thalamocortical (TC) network over 70 full nights of natural sleep in two vervet monkeys. During SWS, BG neurons manifested slow oscillations (∼0.5 Hz) in firing rate that were as prominent as in the TC network. However, in sharp contrast to any neural substrate explored thus far, the slow oscillations in all BG structures were completely desynchronized between individual neurons. Furthermore, whereas in the TC network single-cell spiking was locked to slow oscillations in the local field potential (LFP), the BG LFP exhibited only weak slow oscillatory activity and failed to entrain nearby cells. We thus show that synchrony is not inherent to slow oscillations, and propose that the BG desynchronization of slow oscillations could stem from its unique anatomy and functional connectivity. Finally, we posit that BG slow-oscillation desynchronization may further the reemergence of slow-oscillation traveling waves from multiple independent origins in the frontal cortex, thus significantly contributing to normal SWS.

Neuronal plasticity and thalamocortical sleep and waking oscillations

PubMed Central

Timofeev, Igor

2011-01-01

Throughout life, thalamocortical (TC) network alternates between activated states (wake or rapid eye movement sleep) and slow oscillatory state dominating slow-wave sleep. The patterns of neuronal firing are different during these distinct states. I propose that due to relatively regular firing, the activated states preset some steady state synaptic plasticity and that the silent periods of slow-wave sleep contribute to a release from this steady state synaptic plasticity. In this respect, I discuss how states of vigilance affect short-, mid-, and long-term synaptic plasticity, intrinsic neuronal plasticity, as well as homeostatic plasticity. Finally, I suggest that slow oscillation is intrinsic property of cortical network and brain homeostatic mechanisms are tuned to use all forms of plasticity to bring cortical network to the state of slow oscillation. However, prolonged and profound shift from this homeostatic balance could lead to development of paroxysmal hyperexcitability and seizures as in the case of brain trauma. PMID:21854960

Landau-Kleffner Syndrome, Electrical Status Epilepticus in Slow Wave Sleep, and Language Regression in Children

ERIC Educational Resources Information Center

McVicar, Kathryn A.; Shinnar, Shlomo

2004-01-01

The Landau-Kleffner syndrome (LKS) and electrical status epilepticus in slow wave sleep (ESES) are rare childhood-onset epileptic encephalopathies in which loss of language skills occurs in the context of an epileptiform EEG activated in sleep. Although in LKS the loss of function is limited to language, in ESES there is a wider spectrum of…

Equatorial Magnetohydrodynamic Shallow Water Waves in the Solar Tachocline

NASA Astrophysics Data System (ADS)

Zaqarashvili, Teimuraz

2018-03-01

The influence of a toroidal magnetic field on the dynamics of shallow water waves in the solar tachocline is studied. A sub-adiabatic temperature gradient in the upper overshoot layer of the tachocline causes significant reduction of surface gravity speed, which leads to trapping of the waves near the equator and to an increase of the Rossby wave period up to the timescale of solar cycles. Dispersion relations of all equatorial magnetohydrodynamic (MHD) shallow water waves are obtained in the upper tachocline conditions and solved analytically and numerically. It is found that the toroidal magnetic field splits equatorial Rossby and Rossby-gravity waves into fast and slow modes. For a reasonable value of reduced gravity, global equatorial fast magneto-Rossby waves (with the spatial scale of equatorial extent) have a periodicity of 11 years, matching the timescale of activity cycles. The solutions are confined around the equator between latitudes ±20°–40°, coinciding with sunspot activity belts. Equatorial slow magneto-Rossby waves have a periodicity of 90–100 yr, resembling the observed long-term modulation of cycle strength, i.e., the Gleissberg cycle. Equatorial magneto-Kelvin and slow magneto-Rossby-gravity waves have the periodicity of 1–2 years and may correspond to observed annual and quasi-biennial oscillations. Equatorial fast magneto-Rossby-gravity and magneto-inertia-gravity waves have periods of hundreds of days and might be responsible for observed Rieger-type periodicity. Consequently, the equatorial MHD shallow water waves in the upper overshoot tachocline may capture all timescales of observed variations in solar activity, but detailed analytical and numerical studies are necessary to make a firm conclusion toward the connection of the waves to the solar dynamo.

Establishment of a radiotelemetric recording technique in mice to investigate gastric slow waves: Modulatory role of putative neurotransmitter systems.

PubMed

Wang, Huichuan; Lu, Zengbing; Liu, Yuen Hang; Sun, Yayi; Tu, Longlong; Ngan, Man P; Yeung, Chi-Kong; Rudd, John A

2018-06-01

What is the central question of this study? Gastric slow waves originating from the interstitial cells of Cajal-smooth muscle syncytium are usually studied in culture or in tissue segments, but nobody has described recordings of slow waves from awake, freely moving mice. Can radiotelemetry be used to record slow waves, and do they respond predictably to drug treatment? What is the main finding and its importance? Radiotelemetry can be used to record slow waves from awake, freely moving mice, permitting an examination of drug actions in vivo, which is crucial to drug discovery projects for characterizing the effects of drugs and metabolites on gastrointestinal function. The mouse is the most commonly used species in preclinical research, and isolated tissues are used to study slow waves from the interstitial cells of Cajal-smooth muscle syncytium of the gastrointestinal tract. The aim of this study was to establish a radiotelemetric technique in awake mice to record gastric myoelectric activity from the antrum to gain insight into the effects of endogenous modulatory systems on slow waves. Under general anaesthesia, two biopotential wires from a telemetry transmitter were sutured into the antrum of male ICR (imprinting control region) mice. The animals were allowed 1 week to recover from surgery before the i.p. administration of drugs to stimulate or inhibit slow waves. The basal dominant frequency of slow waves was 6.96 ± 0.43 c.p.m., and the percentages of power in the bradygastric, normogastric and tachygastric ranges were 6.89 ± 0.98, 37.32 ± 1.72 and 34.38 ± 0.77%, respectively (n = 74). Nicotine at 1 mg kg -1 increased normogastric power, but at 3 mg kg -1 it increased bradygastric power (P < 0.05). Metoclopramide at 10 mg kg -1 increased normogastric power; sodium nitroprusside at 10 mg kg -1 had latent effects on tachygastric power (P < 0.05); and l-NAME at 10 mg kg -1 had no effect (P > 0.05). Nicotine and bethanechol also caused varying degrees of hypothermia (>1°C reductions; P < 0.05). In conclusion, radiotelemetry can be used to record slow waves from awake, freely moving mice. In light of our findings, we recommend that studies assessing slow waves should also assess body temperature simultaneously. © 2018 The Authors. Experimental Physiology © 2018 The Physiological Society.

DIFFRACTION, REFRACTION, AND REFLECTION OF AN EXTREME-ULTRAVIOLET WAVE OBSERVED DURING ITS INTERACTIONS WITH REMOTE ACTIVE REGIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen Yuandeng; Liu Yu; Zhao Ruijuan

2013-08-20

We present observations of the diffraction, refraction, and reflection of a global extreme-ultraviolet (EUV) wave propagating in the solar corona. These intriguing phenomena are observed when the wave interacts with two remote active regions, and together they exhibit properties of an EUV wave. When the wave approached AR11465, it became weaker and finally disappeared in the active region, but a few minutes later a new wavefront appeared behind the active region, and it was not concentric with the incoming wave. In addition, a reflected wave was also simultaneously observed on the wave incoming side. When the wave approached AR11459, itmore » transmitted through the active region directly and without reflection. The formation of the new wavefront and the transmission could be explained with diffraction and refraction effects, respectively. We propose that the different behaviors observed during the interactions may be caused by different speed gradients at the boundaries of the two active regions. We find that the EUV wave formed ahead of a group of expanding loops a few minutes after the start of the loops' expansion, which represents the initiation of the associated coronal mass ejection (CME). Based on these results, we conclude that the EUV wave should be a nonlinear magnetosonic wave or shock driven by the associated CME, which propagated faster than the ambient fast mode speed and gradually slowed down to an ordinary linear wave. Our observations support the hybrid model that includes both fast wave and slow non-wave components.« less

Long-term history and immediate preceding state affect EEG slow wave characteristics at NREM sleep onset in C57BL/6 mice.

PubMed

Cui, N; Mckillop, L E; Fisher, S P; Oliver, P L; Vyazovskiy, V V

2014-01-01

The dynamics of cortical activity across the 24-h day and at vigilance state transitions is regulated by an interaction between global subcortical neuromodulatory influences and local shifts in network synchrony and excitability. To address the role of long-term and immediate preceding history in local and global cortical dynamics, we investigated cortical EEG recorded from both frontal and occipital regions during an undisturbed 24-h recording in mice. As expected, at the beginning of the light period, under physiologically increased sleep pressure, EEG slow waves were more frequent and had higher amplitude and slopes, compared to the rest of the light period. Within discrete NREM sleep episodes, the incidence, amplitude and slopes of individual slow waves increased progressively after episode onset in both derivations by approximately 10-30%. Interestingly, at the beginning of NREM sleep episodes slow waves in the frontal and occipital derivations frequently occurred in isolation, as quantified by longer latencies between consecutive slow waves in the two regions. Notably, slow waves during the initial period of NREM sleep following REM sleep episodes were significantly less frequent, lower in amplitude and exhibited shallower slopes, compared to those that occurred in NREM episodes after prolonged waking. Moreover, the latencies between consecutive frontal and occipital NREM slow waves were substantially longer when they occurred directly after REM sleep compared to following consolidated wakefulness. Overall these data reveal a complex picture, where both time of day and preceding state contribute to the characteristics and dynamics of slow waves within NREM sleep. These findings suggest that NREM sleep initiates in a more "local" fashion when it occurs following REM sleep episodes as opposed to sustained waking bouts. While the mechanisms and functional significance of such a re-setting of brain state after individual REM sleep episodes remains to be investigated, we suggest that it may be an essential feature of physiological sleep regulation.

Inhibitory Effects and Sympathetic Mechanisms of Distension in the Distal Organs on Small Bowel Motility and Slow Waves in Canine.

PubMed

Song, Jun; Yin, Jieyun; Chen, Jiande D Z

2015-12-01

Rectal distension (RD) is known to induce intestinal dysmotility. Few studies were performed to compare effects of RD, colon distension (CD) and duodenal distension (DD) on small bowel motility. This study aimed to investigate effects and underlying mechanisms of distensions in these regions on intestinal motility and slow waves. Eight dogs chronically implanted with a duodenal fistula, a proximal colon fistula, and intestinal serosal electrodes were studied in six sessions: control, RD, CD, DD, RD + guanethidine, and CD + guanethidine. Postprandial intestinal contractions and slow waves were recorded for the assessment of intestinal motility. The electrocardiogram was recorded for the assessment of autonomic functions. (1) Isobaric RD and CD suppressed intestinal contractions (contractile index: 6.0 ± 0.4 with RD vs. 9.9 ± 0.9 at baseline, P = 0.001, 5.3 ± 0.2 with CD vs. 7.7 ± 0.8 at baseline, P = 0.008). Guanethidine at 3 mg/kg iv was able to partially block the effects. (2) RD and CD reduced the percentage of normal intestinal slow waves from 92.1 ± 2.8 to 64.2 ± 3.4 % (P < 0.001) and from 90 ± 2.7 to 69.2 ± 3.7 % (P = 0.01), respectively. Guanethidine could eliminate these inhibitory effects. (3) DD did not induce any changes in small intestinal contractions and slow waves (P > 0.05). (4) The spectral analysis of the heart rate variability showed that both RD and CD increased sympathetic activity (LF) and reduced vagal activity (HF) (P < 0.05). Isobaric RD and CD could inhibit postprandial intestinal motility and impair intestinal slow waves, which were mediated via the sympathetic pathway. However, DD at a site proximal to the measurement site did not seem to impair small intestinal contractions or slow waves.

Every slow-wave impulse is associated with motor activity of the human stomach.

PubMed

Hocke, Michael; Schöne, Ulrike; Richert, Hendryk; Görnert, Peter; Keller, Jutta; Layer, Peter; Stallmach, Andreas

2009-04-01

Using a newly developed high-resolution three-dimensional magnetic detector system (3D-MAGMA), we observed periodical movements of a small magnetic marker in the human stomach at the typical gastric slow-wave frequency, that is 3 min(-1). Thus we hypothesized that each gastric slow wave induces a motor response that is not strong enough to be detected by conventional methods. Electrogastrographies (EGG, Medtronic, Minneapolis, MN) for measurement of gastric slow waves and 3D-MAGMA (Innovent, Jena, Germany) measurements were simultaneously performed in 21 healthy volunteers (10 men, 40.4+/-13.6 yr; 11 women, 35.8+/-11.6 yr). The 3D-MAGMA system contains 27 highly sensitive magnetic field sensors that are able to locate a magnetic pill inside a human body with an accuracy of +/-5 mm or less in position and +/-2 degrees in orientation at a frequency of 50 Hz. Gastric transit time of the magnetic marker ranged from 19 to 154 min. The mean dominant EGG frequency while the marker was in the stomach was 2.87+/-0.15 cpm. The mean dominant 3D-MAGMA frequency during this interval was nearly identical; that is, 2.85+/-0.15 movements per minute. We observed a strong linear correlation between individual dominant EGG and 3D-MAGMA frequency (R=0.66, P=0.0011). Our findings suggest that each gastric slow wave induces a minute contraction that is too small to be detected by conventional motility investigations but can be recorded by the 3D-MAGMA system. The present slow-wave theory that assumes that the slow wave is a pure electrical signal should be reconsidered.

Regional variation in contribution of myenteric and intramuscular interstitial cells of Cajal to generation of slow waves in mouse gastric antrum

PubMed Central

Hirst, G D S; Beckett, E A H; Sanders, K M; Ward, S M

2002-01-01

When intracellular recordings were made from the antral region of murine stomach, cells with three different patterns of electrical activity were detected. One group of cells generated follower potentials, the second group generated pacemaker potentials and the third group generated slow waves that consisted of primary and secondary components. Slow waves recorded in different regions of the gastric antrum had similar amplitudes but different characteristic shapes. At the greater curvature, slow waves had large initial components. Midway between the greater and lesser curvature, the amplitude of the initial component was reduced and at the lesser curvature an initial component was difficult to detect. When the distributions of myenteric (ICC-MY) and intramuscular interstitial cells of Cajal (ICC-IM) were determined, using an antibody to Kit, ICC-MY were found to be present at the greater curvature but were greatly reduced in density at the lesser curvature. In contrast, ICC-IM were found in the circular layer of each region. When recordings were made from the antrum of W/WV mice, which lack ICC-IM, incomplete slow waves were detected and their amplitudes fell from the greater to the lesser curvature. Again, a corresponding fall in the density of ICC-MY was detected. The observations indicate that the contribution of ICC-MY and ICC-IM to the generation of slow waves varies in different regions of the mouse gastric antrum. PMID:11986385

Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep.

PubMed

Wisor, J P; Morairty, S R; Huynh, N T; Steininger, T L; Kilduff, T S

2006-08-11

Most hypnotic medications currently on the market target some aspect of GABAergic neurotransmission. Although all such compounds increase sleep, these drugs differentially affect the activity of the cerebral cortex as measured by the electroencephalogram. Whereas benzodiazepine medications such as triazolam tend to suppress slow wave activity in the cortex, the GABA(B) ligand gamma-hydroxybutyrate greatly enhances slow wave activity and the non-benzodiazepine, zolpidem, which binds to the omega1 site on the GABA(A) receptor/Cl(-) ionophore complex, is intermediate in this regard. Our previous studies have demonstrated that a small number of genes exhibit increased expression in the cerebral cortex of the mouse and rat during recovery sleep after sleep deprivation: egr-3, fra-2, grp78, grp94, ngfi-b, and nr4a3. Using these genes as a panel of biomarkers associated with sleep, we asked whether hypnotic medications induce similar molecular changes in the rat cerebral cortex to those observed when both sleep continuity and slow wave activity are enhanced during recovery sleep. We find that, although each drug increases the expression of a subset of genes in the panel of biomarkers, no drug fully replicates the molecular changes in the cortex associated with recovery sleep. Furthermore, high levels of slow wave activity in the cortex are correlated with increased expression of fra-2 whereas the expression of grp94 is correlated with body temperature. These results demonstrate that sleep-related changes in gene expression may be affected by physiological covariates of sleep and wakefulness rather than by vigilance state per se.

Enhanced Memory Consolidation Via Automatic Sound Stimulation During Non-REM Sleep.

PubMed

Leminen, Miika M; Virkkala, Jussi; Saure, Emma; Paajanen, Teemu; Zee, Phyllis C; Santostasi, Giovanni; Hublin, Christer; Müller, Kiti; Porkka-Heiskanen, Tarja; Huotilainen, Minna; Paunio, Tiina

2017-03-01

Slow-wave sleep (SWS) slow waves and sleep spindle activity have been shown to be crucial for memory consolidation. Recently, memory consolidation has been causally facilitated in human participants via auditory stimuli phase-locked to SWS slow waves. Here, we aimed to develop a new acoustic stimulus protocol to facilitate learning and to validate it using different memory tasks. Most importantly, the stimulation setup was automated to be applicable for ambulatory home use. Fifteen healthy participants slept 3 nights in the laboratory. Learning was tested with 4 memory tasks (word pairs, serial finger tapping, picture recognition, and face-name association). Additional questionnaires addressed subjective sleep quality and overnight changes in mood. During the stimulus night, auditory stimuli were adjusted and targeted by an unsupervised algorithm to be phase-locked to the negative peak of slow waves in SWS. During the control night no sounds were presented. Results showed that the sound stimulation increased both slow wave (p = .002) and sleep spindle activity (p < .001). When overnight improvement of memory performance was compared between stimulus and control nights, we found a significant effect in word pair task but not in other memory tasks. The stimulation did not affect sleep structure or subjective sleep quality. We showed that the memory effect of the SWS-targeted individually triggered single-sound stimulation is specific to verbal associative memory. Moreover, the ambulatory and automated sound stimulus setup was promising and allows for a broad range of potential follow-up studies in the future. © Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society].

[Predictors of epilepsy in children after ischemic stroke].

PubMed

Lvova, O A; Shalkevich, L V; Dron, A N; Lukaschuk, M Y; Orlova, E A; Gusev, V V; Suleymanova, E V; Sulimov, A V; Kudlatch, A I

To determine clinical/instrumental predictors of symptomatic epilepsy after ischemic stroke in children. One hundred and thirty-six patients, aged 0-15 years, with the diagnosis of ischemic stroke (ICD-10 I63.0-I63.9) were examined. The duration of the study was 18 months - 12 years. Patients were stratified into post-stroke (n=22) and control (n=114) groups, the latter included patients without epilepsy regardless of the presence of convulsive seizures in the acute stage of stroke. Predictors were determined based on EEG and characteristics of convulsive syndrome in the acute stage of stroke. The following prognostic criteria were found: generalized type of seizures, focal type of seizures with secondary generalization, epileptiform (peak and/or peak-wave) activity, focal character of epileptiform activity, generalized type of seizures in the combination with slow wave background activity on EEG, generalized type of seizures in the combination with slow wave activity and disorganized activity on EEG.

Dissipation of Alfven Waves at Fluid Scale through Parametric Decay Instabilities in Low-beta Turbulent Plasma

NASA Astrophysics Data System (ADS)

Fu, X.; Li, H.; Guo, F.; Li, X.; Roytershteyn, V.

2017-12-01

The solar wind is a turbulent magnetized plasma extending from the upper atmosphere of the sun to the edge of the heliosphere. It carries charged particles and magnetic fields originated from the Sun, which have great impact on the geomagnetic environment and human activities in space. In such a magnetized plasma, Alfven waves play a crucial role in carrying energy from the surface of the Sun, injecting into the solar wind and establishing power-law spectra through turbulent energy cascades. On the other hand, in compressible plasmas large amplitude Alfven waves are subject to a parametric decay instability (PDI) which converts an Alfven wave to another counter-propagating Alfven wave and an ion acoustic wave (slow mode). The counter-propagating Alfven wave provides an important ingredient for turbulent cascade, and the slow-mode wave provides a channel for solar wind heating in a spatial scale much larger than ion kinetic scales. Growth and saturation of PDI in quiet plasma have been intensively studied using linear theory and nonlinear simulations in the past. Here using 3D hybrid simulations, we show that PDI is still effective in turbulent low-beta plasmas, generating slow modes and causing ion heating. Selected events in WIND data are analyzed to identify slow modes in the solar wind and the role of PDI, and compared with our simulation results. We also investigate the validity of linear Vlasov theory regarding PDI growth and slow mode damping in turbulent plasmas. Since PDI favors low plasma beta, we expect to see more evidence of PDI in the solar wind close to the Sun, especially from the upcoming NASA's Parker Solar Probe mission which will provide unprecedented wave and plasma data as close as 8.5 solar radii from the Sun.

The Effects of Caffeine on Sleep and Maturational Markers in the Rat

PubMed Central

Olini, Nadja; Kurth, Salomé; Huber, Reto

2013-01-01

Adolescence is a critical period for brain maturation during which a massive reorganization of cortical connectivity takes place. In humans, slow wave activity (<4.5 Hz) during NREM sleep was proposed to reflect cortical maturation which relies on use-dependent processes. A stimulant like caffeine, whose consumption has recently increased especially in adolescents, is known to affect sleep wake regulation. The goal of this study was to establish a rat model allowing to assess the relationship between cortical maturation and sleep and to further investigate how these parameters are affected by caffeine consumption. To do so, we assessed sleep and markers of maturation by electrophysiological recordings, behavioral and structural readouts in the juvenile rat. Our results show that sleep slow wave activity follows a similar inverted U-shape trajectory as already known in humans. Caffeine treatment exerted short-term stimulating effects and altered the trajectory of slow wave activity. Moreover, caffeine affected behavioral and structural markers of maturation. Thus, caffeine consumption during a critical developmental period shows long lasting effects on sleep and brain maturation. PMID:24023748

Slow-wave propagation on monolithic microwave integrated circuits with layered and non-layered structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tzuang, C.K.C.

1986-01-01

Various MMIC (monolithic microwave integrated circuit) planar waveguides have shown possible existence of a slow-wave propagation. In many practical applications of these slow-wave circuits, the semiconductor devices have nonuniform material properties that may affect the slow-wave propagation. In the first part of the dissertation, the effects of the nonuniform material properties are studied by a finite-element method. In addition, the transient pulse excitations of these slow-wave circuits also have great theoretical and practical interests. In the second part, the time-domain analysis of a slow-wave coplanar waveguide is presented.

Shorter duration of non-rapid eye movement sleep slow waves in EphA4 knockout mice.

PubMed

Freyburger, Marlène; Poirier, Gaétan; Carrier, Julie; Mongrain, Valérie

2017-10-01

Slow waves occurring during non-rapid eye movement sleep have been associated with neurobehavioural performance and memory. In addition, the duration of previous wakefulness and sleep impacts characteristics of these slow waves. However, molecular mechanisms regulating the dynamics of slow-wave characteristics remain poorly understood. The EphA4 receptor regulates glutamatergic transmission and synaptic plasticity, which have both been linked to sleep slow waves. To investigate if EphA4 regulates slow-wave characteristics during non-rapid eye movement sleep, we compared individual parameters of slow waves between EphA4 knockout mice and wild-type littermates under baseline conditions and after a 6-h sleep deprivation. We observed that, compared with wild-type mice, knockout mice display a shorter duration of positive and negative phases of slow waves under baseline conditions and after sleep deprivation. However, the mutation did not change slow-wave density, amplitude and slope, and did not affect the sleep deprivation-dependent changes in slow-wave characteristics, suggesting that EphA4 is not involved in the response to elevated sleep pressure. Our present findings suggest a role for EphA4 in shaping cortical oscillations during sleep that is independent from sleep need. © 2017 European Sleep Research Society.

Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase.

PubMed

Huitron-Resendiz, Salvador; Sanchez-Alavez, Manuel; Wills, Derek N; Cravatt, Benjamin F; Henriksen, Steven J

2004-08-01

Oleamide and anandamide are fatty acid amides implicated in the regulatory mechanisms of sleep processes. However, due to their prompt catabolism by fatty acid amide hydrolase (FAAH), their pharmacologic and behavioral effects, in vivo, disappear rapidly. To determine if, in the absence of FAAH, the hypnogenic fatty acid amides induce an increase of sleep, we characterized the sleep-wake patters in FAAH-knockout mice [FAAH (-/-)] before and after sleep deprivation. FAAH (-/-), FAAH (+/-), and FAAH (+/+) mice were implanted chronically for sleep, body temperature (Tb), and locomotor activity (LMA) recordings. Sleep-wake states were recorded during a 24-hour baseline session followed by 8 hours of sleep deprivation. Recovery recordings were done during the 16 hours following sleep deprivation. Total amount of wake, slow-wave sleep, and rapid eye movement sleep were calculated and compared between genotypes. The electroencephalographic spectral analysis was performed by fast Fourier transform analysis. Telemetry recordings of Tb and LMA were carried out continuously during 4 days under baseline conditions. N/A. FAAH (-/-) mice and their heterozygote (+/-) and control (+/+) littermates were used. Sleep deprivation. FAAH (-/-) mice possess higher values of slow-wave sleep and more intense episodes of slow-wave sleep than do control littermates under baseline conditions that are not related to differences in Tb and LMA. A rebound of slow-wave sleep and rapid eye movement sleep as well an increase in the levels of slow-wave activity were observed after sleep deprivation in all genotypes. These findings support the role of fatty acid amides as possible modulators of sleep and indicate that the homeostatic mechanisms of sleep in FAAH (-/-) mice are not disrupted.

A miniature bidirectional telemetry system for in vivo gastric slow wave recordings.

PubMed

Farajidavar, Aydin; O'Grady, Gregory; Rao, Smitha M N; Cheng, Leo K; Abell, Thomas; Chiao, J-C

2012-06-01

Stomach contractions are initiated and coordinated by an underlying electrical activity (slow waves), and electrical dysrhythmias accompany motility diseases. Electrical recordings taken directly from the stomach provide the most valuable data, but face technical constraints. Serosal or mucosal electrodes have cables that traverse the abdominal wall, or a natural orifice, causing discomfort and possible infection, and restricting mobility. These problems motivated the development of a wireless system. The bidirectional telemetric system constitutes a front-end transponder, a back-end receiver and a graphical userinter face. The front-end module conditions the analogue signals, then digitizes and loads the data into a radio for transmission. Data receipt at the backend is acknowledged via a transceiver function. The system was validated in a bench-top study, then validated in vivo using serosal electrodes connected simultaneously to a commercial wired system. The front-end module was 35 × 35 × 27 mm3 and weighed 20 g. Bench-top tests demonstrated reliable communication within a distance range of 30 m, power consumption of 13.5 mW, and 124 h operation when utilizing a 560 mAh, 3 V battery. In vivo,slow wave frequencies were recorded identically with the wireless and wired reference systems (2.4 cycles min−1), automated activation time detection was modestly better for the wireless system (5% versus 14% FP rate), and signal amplitudes were modestly higher via the wireless system (462 versus 3 86μV; p<0.001). This telemetric system for slow wave acquisition is reliable,power efficient, readily portable and potentially implantable. The device will enable chronic monitoring and evaluation of slow wave patterns in animals and patients.0967-3334/

A miniature bidirectional telemetry system for in-vivo gastric slow wave recordings

PubMed Central

Farajidavar, Aydin; O’Grady, Gregory; Rao, Smitha M.N.; Cheng, Leo K; Abell, Thomas; Chiao, J.-C.

2012-01-01

Stomach contractions are initiated and coordinated by an underlying electrical activity (slow waves), and electrical dysrhythmias accompany motility diseases. Electrical recordings taken directly from the stomach provide the most valuable data, but face technical constraints. Serosal or mucosal electrodes have cables that traverse the abdominal wall, or a natural orifice, causing discomfort and possible infection, and restricting mobility. These problems motivated the development of a wireless system. The bidirectional telemetric system constitutes a front-end transponder, a back-end receiver and a graphical user interface. The front-end module conditions the analog signals, then digitizes and loads the data into a radio for transmission. Data receipt at the back-end is acknowledged via a transceiver function. The system was validated in a bench-top study, then validated in-vivo using serosal electrodes connected simultaneously to a commercial wired system. The front-end module was 35×35×27 mm3 and weighed 20 g. Bench-top tests demonstrated reliable communication within a distance range of 30 m, power consumption of 13.5 mW, and 124-hour operation when utilizing a 560-mAh, 3-V battery. In-vivo, slow wave frequencies were recorded identically with the wireless and wired reference systems (2.4 cycles/min), automated activation time detection was modestly better for the wireless system (5% vs 14% false positive rate), and signal amplitudes were modestly higher via the wireless system (462 vs 386 μV; p<0.001). This telemetric system for slow wave acquisition is reliable, power efficient, readily portable and potentially implantable. The device will enable chronic monitoring and evaluation of slow wave patterns in animals and patients. PMID:22635054

Excitation of flare-induced waves in coronal loops and the effects of radiative cooling

NASA Astrophysics Data System (ADS)

Provornikova, Elena; Ofman, Leon; Wang, Tongjiang

2018-01-01

EUV imaging observations from several space missions (SOHO/EIT, TRACE, and SDO/AIA) have revealed a presence of propagating intensity disturbances in solar coronal loops. These disturbances are typically interpreted as slow magnetoacoustic waves. However, recent spectroscopic observations with Hinode/EIS of active region loops revealed that the propagating intensity disturbances are associated with intermittent plasma upflows (or jets) at the footpoints which are presumably generated by magnetic reconnection. For this reason, whether these disturbances are waves or periodic flows is still being studied. This study is aimed at understanding the physical properties of observed disturbances by investigating the excitation of waves by hot plasma injections from below and the evolution of flows and wave propagation along the loop. We expand our previous studies based on isothermal 3D MHD models of an active region to a more realistic model that includes full energy equation accounting for the effects of radiative losses. Computations are initialized with an equilibrium state of a model active region using potential (dipole) magnetic field, gravitationally stratified density and temperature obtained from the polytropic equation of state. We model an impulsive injection of hot plasma into the steady plasma outflow along the loops of different temperatures, warm (∼1 MK) and hot (∼6 MK). The simulations show that hot jets launched at the coronal base excite slow magnetoacoustic waves that propagate to high altitudes along the loops, while the injected hot flows decelerate rapidly with heights. Our results support that propagating disturbances observed in EUV are mainly the wave features. We also find that the effect of radiative cooling on the damping of slow-mode waves in 1-6 MK coronal loops is small, in agreement with the previous conclusion based on 1D MHD models.

Ketamine, sleep, and depression: current status and new questions.

PubMed

Duncan, Wallace C; Zarate, Carlos A

2013-09-01

Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has well-described rapid antidepressant effects in clinical studies of individuals with treatment-resistant major depressive disorder (MDD). Preclinical studies investigating the effects of ketamine on brain-derived neurotrophic factor (BDNF) and on sleep slow wave activity (SWA) support its use as a prototype for investigating the neuroplastic mechanisms presumably involved in the mechanism of rapidly acting antidepressants. This review discusses human EEG slow wave sleep parameters and plasma BDNF as central and peripheral surrogate markers of plasticity, and their use in assessing ketamine's effects. Acutely, ketamine elevates BDNF levels, as well as early night SWA and high-amplitude slow waves; each of these measures correlates with change in mood in depressed patients who respond to ketamine. The slow wave effects are limited to the first night post-infusion, suggesting that their increase is part of an early cascade of events triggering improved mood. Increased total sleep and decreased waking occur during the first and second night post infusion, suggesting that these measures are associated with the enduring treatment response observed with ketamine.

Induction of slow oscillations by rhythmic acoustic stimulation.

PubMed

Ngo, Hong-Viet V; Claussen, Jens C; Born, Jan; Mölle, Matthias

2013-02-01

Slow oscillations are electrical potential oscillations with a spectral peak frequency of ∼0.8 Hz, and hallmark the electroencephalogram during slow-wave sleep. Recent studies have indicated a causal contribution of slow oscillations to the consolidation of memories during slow-wave sleep, raising the question to what extent such oscillations can be induced by external stimulation. Here, we examined whether slow oscillations can be effectively induced by rhythmic acoustic stimulation. Human subjects were examined in three conditions: (i) with tones presented at a rate of 0.8 Hz ('0.8-Hz stimulation'); (ii) with tones presented at a random sequence ('random stimulation'); and (iii) with no tones presented in a control condition ('sham'). Stimulation started during wakefulness before sleep and continued for the first ∼90 min of sleep. Compared with the other two conditions, 0.8-Hz stimulation significantly delayed sleep onset. However, once sleep was established, 0.8-Hz stimulation significantly increased and entrained endogenous slow oscillation activity. Sleep after the 90-min period of stimulation did not differ between the conditions. Our data show that rhythmic acoustic stimulation can be used to effectively enhance slow oscillation activity. However, the effect depends on the brain state, requiring the presence of stable non-rapid eye movement sleep. © 2012 European Sleep Research Society.

Thalamic Atrophy Contributes to Low Slow Wave Sleep in Neuromyelitis Optica Spectrum Disorder.

PubMed

Su, Lei; Han, Yujuan; Xue, Rong; Wood, Kristofer; Shi, Fu-Dong; Liu, Yaou; Fu, Ying

2016-12-01

Slow wave sleep abnormality has been reported in neuromyelitis optica spectrum disorder (NMOSD), but mechanism for such abnormality is unknown. To determine the structural defects in the brain that account for the decrease of slow wave sleep in NMOSD patients. Thirty-three NMOSD patients and 18 matched healthy controls (HC) were enrolled. Polysomnography was used to monitor slow wave sleep and three-dimensional T1-weighted MRIs were obtained to assess the alterations of grey matter volume. The percentage of deep slow wave sleep decreased in 93% NMOSD patients. Compared to HC, a reduction of grey matter volume was found in the bilateral thalamus of patients with a lower percentage of slow wave sleep (FWE corrected at cluster-level, p < 0.05, cluster size > 400 voxels). Furthermore, the right thalamic fraction was positively correlated with the decrease in the percentage of slow wave sleep in NMOSD patients (p < 0.05, FDR corrected, cluster size > 200 voxels). Our study identified that thalamic atrophy is associated with the decrease of slow wave sleep in NMOSD patients. Further studies should evaluate whether neurotransmitters or hormones which stem from thalamus are involved in the decrease of slow wave sleep.

Lower hybrid accessibility in a large, hot reversed field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dziubek, R.A.

1995-02-01

Recent theoretical and experimental results indicate that driving a current in the outer radius of an RPF suppresses sawtooth activity and increases particle and energy confinement times. One candidate for a form of steady state current drive is the slow wave at the lower hybrid frequency. Here, the accessibility of such a wave in an RFP plasma is investigated theoretically, with focus on the RFX machine of Padua, Italy. To drive current, the slow wave with frequency between 1.0--1.5 GHz is considered where optimal Landau damping is desired at r/a {approximately} 0.7. By numerically determining the values of the wave`smore » perpendicular index of refraction which satisfy the hot plasma dispersion relation, regions of propagation and evanescence can be found. The path of the wave can then be traced over a contour map of these regions so that accessibility can be clearly seen. The possibility of mode conversion events can be ascertained by plotting the values of the perpendicular index of refraction for the fast and slow wave and observing convergence points. To locate regions of maximum Landau damping, a technique developed by Stix was adapted for use with the slow wave in an RFP plasma. Results show that the slow wave is accessible to the target region without mode conversion so long as the value of the parallel index of refraction is correctly chosen at the edge of the plasma. Landau damping can also be optimized with this method. In an RFP, 2--20% of the electron population consists of fast electrons. Because this species alters the total electron distribution function and raises the effective temperature in the outer regions of the plasma, its presence is expected to shift the location of ideal Landau damping.« less

Why Does Sleep Slow-Wave Activity Increase After Extended Wake? Assessing the Effects of Increased Cortical Firing During Wake and Sleep

PubMed Central

Rodriguez, Alexander V.; Funk, Chadd M.; Vyazovskiy, Vladyslav V.; Nir, Yuval; Tononi, Giulio

2016-01-01

During non-rapid eye movement (NREM) sleep, cortical neurons alternate between ON periods of firing and OFF periods of silence. This bi-stability, which is largely synchronous across neurons, is reflected in the EEG as slow waves. Slow-wave activity (SWA) increases with wake duration and declines homeostatically during sleep, but the underlying mechanisms remain unclear. One possibility is neuronal “fatigue”: high, sustained firing in wake would force neurons to recover with more frequent and longer OFF periods during sleep. Another possibility is net synaptic potentiation during wake: stronger coupling among neurons would lead to greater synchrony and therefore higher SWA. Here, we obtained a comparable increase in sustained firing (6 h) in cortex by: (1) keeping mice awake by exposure to novel objects to promote plasticity and (2) optogenetically activating a local population of cortical neurons at wake-like levels during sleep. Sleep after extended wake led to increased SWA, higher synchrony, and more time spent OFF, with a positive correlation between SWA, synchrony, and OFF periods. Moreover, time spent OFF was correlated with cortical firing during prior wake. After local optogenetic stimulation, SWA and cortical synchrony decreased locally, time spent OFF did not change, and local SWA was not correlated with either measure. Moreover, laser-induced cortical firing was not correlated with time spent OFF afterward. Overall, these results suggest that high sustained firing per se may not be the primary determinant of SWA increases observed after extended wake. SIGNIFICANCE STATEMENT A long-standing hypothesis is that neurons fire less during slow-wave sleep to recover from the “fatigue” accrued during wake, when overall synaptic activity is higher than in sleep. This idea, however, has rarely been tested and other factors, namely increased cortical synchrony, could explain why sleep slow-wave activity (SWA) is higher after extended wake. We forced neurons in the mouse cortex to fire at high levels for 6 h in 2 different conditions: during active wake with exploration and during sleep. We find that neurons need more time OFF only after sustained firing in wake, suggesting that fatigue due to sustained firing alone is unlikely to account for the increase in SWA that follows sleep deprivation. PMID:27927960

Why Does Sleep Slow-Wave Activity Increase After Extended Wake? Assessing the Effects of Increased Cortical Firing During Wake and Sleep.

PubMed

Rodriguez, Alexander V; Funk, Chadd M; Vyazovskiy, Vladyslav V; Nir, Yuval; Tononi, Giulio; Cirelli, Chiara

2016-12-07

During non-rapid eye movement (NREM) sleep, cortical neurons alternate between ON periods of firing and OFF periods of silence. This bi-stability, which is largely synchronous across neurons, is reflected in the EEG as slow waves. Slow-wave activity (SWA) increases with wake duration and declines homeostatically during sleep, but the underlying mechanisms remain unclear. One possibility is neuronal "fatigue": high, sustained firing in wake would force neurons to recover with more frequent and longer OFF periods during sleep. Another possibility is net synaptic potentiation during wake: stronger coupling among neurons would lead to greater synchrony and therefore higher SWA. Here, we obtained a comparable increase in sustained firing (6 h) in cortex by: (1) keeping mice awake by exposure to novel objects to promote plasticity and (2) optogenetically activating a local population of cortical neurons at wake-like levels during sleep. Sleep after extended wake led to increased SWA, higher synchrony, and more time spent OFF, with a positive correlation between SWA, synchrony, and OFF periods. Moreover, time spent OFF was correlated with cortical firing during prior wake. After local optogenetic stimulation, SWA and cortical synchrony decreased locally, time spent OFF did not change, and local SWA was not correlated with either measure. Moreover, laser-induced cortical firing was not correlated with time spent OFF afterward. Overall, these results suggest that high sustained firing per se may not be the primary determinant of SWA increases observed after extended wake. A long-standing hypothesis is that neurons fire less during slow-wave sleep to recover from the "fatigue" accrued during wake, when overall synaptic activity is higher than in sleep. This idea, however, has rarely been tested and other factors, namely increased cortical synchrony, could explain why sleep slow-wave activity (SWA) is higher after extended wake. We forced neurons in the mouse cortex to fire at high levels for 6 h in 2 different conditions: during active wake with exploration and during sleep. We find that neurons need more time OFF only after sustained firing in wake, suggesting that fatigue due to sustained firing alone is unlikely to account for the increase in SWA that follows sleep deprivation. Copyright © 2016 the authors 0270-6474/16/3612436-12$15.00/0.

First Imaging Observation of Standing Slow Wave in Coronal Fan Loops

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pant, V.; Tiwari, A.; Banerjee, D.

2017-09-20

We observe intensity oscillations along coronal fan loops associated with the active region AR 11428. The intensity oscillations were triggered by blast waves that were generated due to X-class flares in the distant active region AR 11429. To characterize the nature of oscillations, we created time–distance maps along the fan loops and noted that the intensity oscillations at two ends of the loops were out of phase. As we move along the fan loop, the amplitude of the oscillations first decreased and then increased. The out-of-phase nature together with the amplitude variation along the loop implies that these oscillations aremore » very likely to be standing waves. The period of the oscillations is estimated to be ∼27 minutes, damping time to be ∼45 minutes, and phase velocity projected in the plane of sky to be ∼65–83 km s{sup −1}. The projected phase speeds were in the range of the acoustic speed of coronal plasma at about 0.6 MK, which further indicates that these are slow waves. To the best of our knowledge, this is the first report on the existence of the standing slow waves in non-flaring fan loops.« less

Extracellular Cl- regulates electrical slow waves and setting of smooth muscle membrane potential by interstitial cells of Cajal in mouse jejunum.

PubMed

Saravanaperumal, Siva Arumugam; Gibbons, Simon J; Malysz, John; Sha, Lei; Linden, David R; Szurszewski, Joseph H; Farrugia, Gianrico

2018-01-01

What is the central question of this study? The aim was to investigate the roles of extracellular chloride in electrical slow waves and resting membrane potential of mouse jejunal smooth muscle by replacing chloride with the impermeant anions gluconate and isethionate. What is the main finding and its importance? The main finding was that in smooth muscle cells, the resting Cl - conductance is low, whereas transmembrane Cl - movement in interstitial cells of Cajal (ICCs) is a major contributor to the shape of electrical slow waves. Furthermore, the data confirm that ICCs set the smooth muscle membrane potential and that altering Cl - homeostasis in ICCs can alter the smooth muscle membrane potential. Intracellular Cl - homeostasis is regulated by anion-permeable channels and transporters and contributes to excitability of many cell types, including smooth muscle and interstitial cells of Cajal (ICCs). Our aims were to investigate the effects on electrical activity in mouse jejunal muscle strips of replacing extracellular Cl - (Cl - o ) with the impermeant anions gluconate and isethionate. On reducing Cl - o , effects were observed on electrical slow waves, with small effects on smooth muscle membrane voltage (E m ). Restoration of Cl - hyperpolarized smooth muscle E m proportional to the change in Cl - o concentration. Replacement of 90% of Cl - o with gluconate reversibly abolished slow waves in five of nine preparations. Slow waves were maintained in isethionate. Gluconate and isethionate substitution had similar concentration-dependent effects on peak amplitude, frequency, width at half peak amplitude, rise time and decay time of residual slow waves. Gluconate reduced free ionized Ca 2+ in Krebs solutions to 0.13 mm. In Krebs solutions containing normal Cl - and 0.13 mm free Ca 2+ , slow wave frequency was lower, width at half peak amplitude was smaller, and decay time was faster. The transient hyperpolarization following restoration of Cl - o was not observed in W/W v mice, which lack pacemaker ICCs in the small intestine. We conclude that in smooth muscle cells, the resting Cl - conductance is low, whereas transmembrane Cl - movement in ICCs plays a major role in generation or propagation of slow waves. Furthermore, these data support a role for ICCs in setting smooth muscle E m and that altering Cl - homeostasis in ICCs can alter smooth muscle E m . © 2017 Mayo Clinic. Experimental Physiology © 2017 The Physiological Society.

Time-domain separation of interfering waves in cancellous bone using bandlimited deconvolution: simulation and phantom study.

PubMed

Wear, Keith A

2014-04-01

In through-transmission interrogation of cancellous bone, two longitudinal pulses ("fast" and "slow" waves) may be generated. Fast and slow wave properties convey information about material and micro-architectural characteristics of bone. However, these properties can be difficult to assess when fast and slow wave pulses overlap in time and frequency domains. In this paper, two methods are applied to decompose signals into fast and slow waves: bandlimited deconvolution and modified least-squares Prony's method with curve-fitting (MLSP + CF). The methods were tested in plastic and Zerdine(®) samples that provided fast and slow wave velocities commensurate with velocities for cancellous bone. Phase velocity estimates were accurate to within 6 m/s (0.4%) (slow wave with both methods and fast wave with MLSP + CF) and 26 m/s (1.2%) (fast wave with bandlimited deconvolution). Midband signal loss estimates were accurate to within 0.2 dB (1.7%) (fast wave with both methods), and 1.0 dB (3.7%) (slow wave with both methods). Similar accuracies were found for simulations based on fast and slow wave parameter values published for cancellous bone. These methods provide sufficient accuracy and precision for many applications in cancellous bone such that experimental error is likely to be a greater limiting factor than estimation error.

Guided wave phenomena in millimeter wave integrated circuits and components

NASA Astrophysics Data System (ADS)

Itoh, Tatsuo

1993-01-01

Representative projects from Army Research Office are summarized. Following the narrative descriptions with appropriate illustrations, a complete list of articles published in scientific journals and those presented at national and international conferences is provided. Lists of personnel and advanced degrees are also included. The projects were carried out at The University of Texas at Austin and later at UCLA. Topics covered include: quasi-optical technique; active antenna; active filter; traveling wave transistor; slow wave, planar transmission line; and discontinuities.

Hippocampal ripples down-regulate synapses.

PubMed

Norimoto, Hiroaki; Makino, Kenichi; Gao, Mengxuan; Shikano, Yu; Okamoto, Kazuki; Ishikawa, Tomoe; Sasaki, Takuya; Hioki, Hiroyuki; Fujisawa, Shigeyoshi; Ikegaya, Yuji

2018-03-30

The specific effects of sleep on synaptic plasticity remain unclear. We report that mouse hippocampal sharp-wave ripple oscillations serve as intrinsic events that trigger long-lasting synaptic depression. Silencing of sharp-wave ripples during slow-wave states prevented the spontaneous down-regulation of net synaptic weights and impaired the learning of new memories. The synaptic down-regulation was dependent on the N -methyl-d-aspartate receptor and selective for a specific input pathway. Thus, our findings are consistent with the role of slow-wave states in refining memory engrams by reducing recent memory-irrelevant neuronal activity and suggest a previously unrecognized function for sharp-wave ripples. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Two-wave propagation in in vitro swine distal ulna

NASA Astrophysics Data System (ADS)

Mano, Isao; Horii, Kaoru; Matsukawa, Mami; Otani, Takahiko

2015-07-01

Ultrasonic transmitted waves were obtained in an in vitro swine distal ulna specimen, which mimics a human distal radius, that consists of interconnected cortical bone and cancellous bone. The transmitted waveforms appeared similar to the fast waves, slow waves, and overlapping fast and slow waves measured in the specimen after removing the surface cortical bone (only cancellous bone). In addition, the circumferential waves in the cortical bone and water did not affect the fast and slow waves. This suggests that the fast-and-slow-wave phenomenon can be observed in an in vivo human distal radius.

Nigrostriatal lesion induces D2-modulated phase-locked activity in the basal ganglia of rats.

PubMed

Zold, Camila L; Ballion, Bérangère; Riquelme, Luis A; Gonon, François; Murer, M Gustavo

2007-04-01

There is a debate as to what modifications of neuronal activity underlie the clinical manifestations of Parkinson's disease and the efficacy of antiparkinsonian pharmacotherapy. Previous studies suggest that release of GABAergic striatopallidal neurons from D2 receptor-mediated inhibition allows spreading of cortical rhythms to the globus pallidus (GP) in rats with 6-hydroxydopamine-induced nigrostriatal lesions. Here this abnormal spreading was thoroughly investigated. In control urethane-anaesthetized rats most GP neurons were excited during the active part of cortical slow waves ('direct-phase' neurons). Two neuronal populations having opposite phase relationships with cortical and striatal activity coexisted in the GP of 6-hydroxydopamine-lesioned rats. 'Inverse-phase' GP units exhibited reduced firing coupled to striatal activation during slow waves, suggesting that this GP oscillation was driven by striatopallidal hyperactivity. Half of the pallidonigral neurons identified by antidromic stimulation exhibited inverse-phase activity. Therefore, spreading of inverse-phase oscillations through pallidonigral axons might contribute to the abnormal direct-phase cortical entrainment of basal ganglia output described previously. Systemic administration of the D2 agonist quinpirole to 6-hydroxydopamine-lesioned rats reduced GP inverse-phase coupling with slow waves, and this effect was reversed by the D2 antagonist eticlopride. Because striatopallidal hyperactivity was only slightly reduced by quinpirole, other mechanisms might have contributed to the effect of quinpirole on GP oscillations. These results suggest that antiparkinsonian efficacy may rely on other actions of D2 agonists on basal ganglia activity. However, abnormal slow rhythms may promote enduring changes in functional connectivity along the striatopallidal axis, contributing to D2 agonist-resistant clinical signs of parkinsonism.

Common oscillatory mechanisms across multiple memory systems

NASA Astrophysics Data System (ADS)

Headley, Drew B.; Paré, Denis

2017-01-01

The cortex, hippocampus, and striatum support dissociable forms of memory. While each of these regions contains specialized circuitry supporting their respective functions, all structure their activities across time with delta, theta, and gamma rhythms. We review how these oscillations are generated and how they coordinate distinct memory systems during encoding, consolidation, and retrieval. First, gamma oscillations occur in all regions and coordinate local spiking, compressing it into short population bursts. Second, gamma oscillations are modulated by delta and theta oscillations. Third, oscillatory dynamics in these memory systems can operate in either a "slow" or "fast" mode. The slow mode happens during slow-wave sleep and is characterized by large irregular activity in the hippocampus and delta oscillations in cortical and striatal circuits. The fast mode occurs during active waking and rapid eye movement (REM) sleep and is characterized by theta oscillations in the hippocampus and its targets, along with gamma oscillations in the rest of cortex. In waking, the fast mode is associated with the efficacious encoding and retrieval of declarative and procedural memories. Theta and gamma oscillations have similar relationships with encoding and retrieval across multiple forms of memory and brain regions, despite regional differences in microcircuitry and information content. Differences in the oscillatory coordination of memory systems during sleep might explain why the consolidation of some forms of memory is sensitive to slow-wave sleep, while others depend on REM. In particular, theta oscillations appear to support the consolidation of certain types of procedural memories during REM, while delta oscillations during slow-wave sleep seem to promote declarative and procedural memories.

Detection of changes of high-frequency activity by statistical time-frequency analysis in epileptic spikes

PubMed Central

Kobayashi, Katsuhiro; Jacobs, Julia; Gotman, Jean

2013-01-01

Objective A novel type of statistical time-frequency analysis was developed to elucidate changes of high-frequency EEG activity associated with epileptic spikes. Methods The method uses the Gabor Transform and detects changes of power in comparison to background activity using t-statistics that are controlled by the false discovery rate (FDR) to correct type I error of multiple testing. The analysis was applied to EEGs recorded at 2000 Hz from three patients with mesial temporal lobe epilepsy. Results Spike-related increase of high-frequency oscillations (HFOs) was clearly shown in the FDR-controlled t-spectra: it was most dramatic in spikes recorded from the hippocampus when the hippocampus was the seizure onset zone (SOZ). Depression of fast activity was observed immediately after the spikes, especially consistently in the discharges from the hippocampal SOZ. It corresponded to the slow wave part in case of spike-and-slow-wave complexes, but it was noted even in spikes without apparent slow waves. In one patient, a gradual increase of power above 200 Hz preceded spikes. Conclusions FDR-controlled t-spectra clearly detected the spike-related changes of HFOs that were unclear in standard power spectra. Significance We developed a promising tool to study the HFOs that may be closely linked to the pathophysiology of epileptogenesis. PMID:19394892

Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis.

PubMed

Faville, R A; Pullan, A J; Sanders, K M; Koh, S D; Lloyd, C M; Smith, N P

2009-06-17

Spontaneously rhythmic pacemaker activity produced by interstitial cells of Cajal (ICC) is the result of the entrainment of unitary potential depolarizations generated at intracellular sites termed pacemaker units. In this study, we present a mathematical modeling framework that quantitatively represents the transmembrane ion flows and intracellular Ca2+ dynamics from a single ICC operating over the physiological membrane potential range. The mathematical model presented here extends our recently developed biophysically based pacemaker unit modeling framework by including mechanisms necessary for coordinating unitary potential events, such as a T-Type Ca2+ current, Vm-dependent K+ currents, and global Ca2+ diffusion. Model simulations produce spontaneously rhythmic slow wave depolarizations with an amplitude of 65 mV at a frequency of 17.4 cpm. Our model predicts that activity at the spatial scale of the pacemaker unit is fundamental for ICC slow wave generation, and Ca2+ influx from activation of the T-Type Ca2+ current is required for unitary potential entrainment. These results suggest that intracellular Ca2+ levels, particularly in the region local to the mitochondria and endoplasmic reticulum, significantly influence pacing frequency and synchronization of pacemaker unit discharge. Moreover, numerical investigations show that our ICC model is capable of qualitatively replicating a wide range of experimental observations.

Interacting Turing-Hopf Instabilities Drive Symmetry-Breaking Transitions in a Mean-Field Model of the Cortex: A Mechanism for the Slow Oscillation

NASA Astrophysics Data System (ADS)

Steyn-Ross, Moira L.; Steyn-Ross, D. A.; Sleigh, J. W.

2013-04-01

Electrical recordings of brain activity during the transition from wake to anesthetic coma show temporal and spectral alterations that are correlated with gross changes in the underlying brain state. Entry into anesthetic unconsciousness is signposted by the emergence of large, slow oscillations of electrical activity (≲1Hz) similar to the slow waves observed in natural sleep. Here we present a two-dimensional mean-field model of the cortex in which slow spatiotemporal oscillations arise spontaneously through a Turing (spatial) symmetry-breaking bifurcation that is modulated by a Hopf (temporal) instability. In our model, populations of neurons are densely interlinked by chemical synapses, and by interneuronal gap junctions represented as an inhibitory diffusive coupling. To demonstrate cortical behavior over a wide range of distinct brain states, we explore model dynamics in the vicinity of a general-anesthetic-induced transition from “wake” to “coma.” In this region, the system is poised at a codimension-2 point where competing Turing and Hopf instabilities coexist. We model anesthesia as a moderate reduction in inhibitory diffusion, paired with an increase in inhibitory postsynaptic response, producing a coma state that is characterized by emergent low-frequency oscillations whose dynamics is chaotic in time and space. The effect of long-range axonal white-matter connectivity is probed with the inclusion of a single idealized point-to-point connection. We find that the additional excitation from the long-range connection can provoke seizurelike bursts of cortical activity when inhibitory diffusion is weak, but has little impact on an active cortex. Our proposed dynamic mechanism for the origin of anesthetic slow waves complements—and contrasts with—conventional explanations that require cyclic modulation of ion-channel conductances. We postulate that a similar bifurcation mechanism might underpin the slow waves of natural sleep and comment on the possible consequences of chaotic dynamics for memory processing and learning.

The role of fast and slow EEG activity during sleep in males and females with Major Depressive Disorder

PubMed Central

Cheng, Philip; Goldschmied, Jennifer; Deldin, Patricia; Hoffmann, Robert; Armitage, Roseanne

2015-01-01

Sleep difficulties are highly prevalent in depression, and appears to be a contributing factor in the development and maintenance of symptoms. However, despite the generally acknowledged relationship between sleep and depression, the neurophysiological substrates underlying this relationship still remain unclear. Two main hypotheses were tested in this study. The first hypothesis states that sleep in depression is characterized by inadequate generation of restorative sleep, as indexed by reduced amounts of slow-wave activity. Conversely, the second hypothesis states that poor sleep in depression is due to intrusions of fast-frequency activity that may be reflective of a hyperaroused central nervous system. This study aimed to test both hypotheses in a large sample of individuals with clinically validated depression, as well as examine sex as a moderator. Results suggest that depression is better characterized by an overall decrease in slow-wave activity, which is related to elevated anxious and depressed mood the following morning. Results also suggest that females may be more likely to experience fast frequency activity related to depression symptom severity. PMID:26175101

Effects of partial sleep deprivation on slow waves during non-rapid eye movement sleep: A high density EEG investigation.

PubMed

Plante, David T; Goldstein, Michael R; Cook, Jesse D; Smith, Richard; Riedner, Brady A; Rumble, Meredith E; Jelenchick, Lauren; Roth, Andrea; Tononi, Giulio; Benca, Ruth M; Peterson, Michael J

2016-02-01

Changes in slow waves during non-rapid eye movement (NREM) sleep in response to acute total sleep deprivation are well-established measures of sleep homeostasis. This investigation utilized high-density electroencephalography (hdEEG) to examine topographic changes in slow waves during repeated partial sleep deprivation. Twenty-four participants underwent a 6-day sleep restriction protocol. Spectral and period-amplitude analyses of sleep hdEEG data were used to examine changes in slow wave energy, count, amplitude, and slope relative to baseline. Changes in slow wave energy were dependent on the quantity of NREM sleep utilized for analysis, with widespread increases during sleep restriction and recovery when comparing data from the first portion of the sleep period, but restricted to recovery sleep if the entire sleep episode was considered. Period-amplitude analysis was less dependent on the quantity of NREM sleep utilized, and demonstrated topographic changes in the count, amplitude, and distribution of slow waves, with frontal increases in slow wave amplitude, numbers of high-amplitude waves, and amplitude/slopes of low amplitude waves resulting from partial sleep deprivation. Topographic changes in slow waves occur across the course of partial sleep restriction and recovery. These results demonstrate a homeostatic response to partial sleep loss in humans. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Slow Feature Analysis on Retinal Waves Leads to V1 Complex Cells

PubMed Central

Dähne, Sven; Wilbert, Niko; Wiskott, Laurenz

2014-01-01

The developing visual system of many mammalian species is partially structured and organized even before the onset of vision. Spontaneous neural activity, which spreads in waves across the retina, has been suggested to play a major role in these prenatal structuring processes. Recently, it has been shown that when employing an efficient coding strategy, such as sparse coding, these retinal activity patterns lead to basis functions that resemble optimal stimuli of simple cells in primary visual cortex (V1). Here we present the results of applying a coding strategy that optimizes for temporal slowness, namely Slow Feature Analysis (SFA), to a biologically plausible model of retinal waves. Previously, SFA has been successfully applied to model parts of the visual system, most notably in reproducing a rich set of complex-cell features by training SFA with quasi-natural image sequences. In the present work, we obtain SFA units that share a number of properties with cortical complex-cells by training on simulated retinal waves. The emergence of two distinct properties of the SFA units (phase invariance and orientation tuning) is thoroughly investigated via control experiments and mathematical analysis of the input-output functions found by SFA. The results support the idea that retinal waves share relevant temporal and spatial properties with natural visual input. Hence, retinal waves seem suitable training stimuli to learn invariances and thereby shape the developing early visual system such that it is best prepared for coding input from the natural world. PMID:24810948

Synchronization Properties of Slow Cortical Oscillations

NASA Astrophysics Data System (ADS)

Takekawa, T.; Aoyagi, T.; Fukai, T.

During slow-wave sleep, the brain shows slow oscillatory activity with remarkable long-range synchrony. Intracellular recordings show that the slow oscillation consists of two phases: an textit{up} state and a textit{down} state. Deriving the phase-response function of simplified neuronal systems, we examine the synchronization properties on slow oscillations between the textit{up} state and the textit{down} state. As a result, the strange interaction functions are found in some parameter ranges. These functions indicate that the states with the smaller phase lag than a critical value are all stable.

Generation and preservation of the slow underlying membrane potential oscillation in model bursting neurons.

PubMed

Franklin, Clarence C; Ball, John M; Schulz, David J; Nair, Satish S

2010-09-01

The underlying membrane potential oscillation of both forced and endogenous slow-wave bursting cells affects the number of spikes per burst, which in turn affects outputs downstream. We use a biophysical model of a class of slow-wave bursting cells with six active currents to investigate and generalize correlations among maximal current conductances that might generate and preserve its underlying oscillation. We propose three phases for the underlying oscillation for this class of cells: generation, maintenance, and termination and suggest that different current modules coregulate to preserve the characteristics of each phase. Coregulation of I(Burst) and I(A) currents within distinct boundaries maintains the dynamics during the generation phase. Similarly, coregulation of I(CaT) and I(Kd) maintains the peak and duration of the underlying oscillation, whereas the calcium-activated I(KCa) ensures appropriate termination of the oscillation and adjusts the duration independent of peak.

Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland

PubMed Central

Dey, Anupa; Kusljic, Snezana; Lang, Richard J; Exintaris, Betty

2010-01-01

BACKGROUND AND PURPOSE To investigate the role of connexin 43 in the maintenance of spontaneous activity in prostate tissue from young and old guinea pigs. EXPERIMENTAL APPROACH Conventional intracellular microelectrode and tension recording techniques, coupled with Western blot analysis and immunohistochemistry for connexin 43 (CX43) were used. The effects of three gap junction uncouplers, 18β glycyrrhetinic acid (10 µM, 40 µM), carbenoxolone (10 µM, 50 µM) and octanol (0.5 mM, 1 mM), were studied in cells displaying slow wave activity and on spontaneously contracting tissue from prostate glands of young (2–5 months) and old (9–16 months) guinea pigs. KEY RESULTS 18β Glycyrrhetinic acid (40 µM), carbenoxolone (50 µM) or octanol (0.5 mM) abolished slow wave activity in prostate tissue from young and old guinea pigs and depolarized membrane potential by approximately 5 mV. These treatments also abolished all contractions in both sets of prostate tissue. These effects were reversed upon washout. Western blot analysis and CX43 immunohistochemistry showed that there was no age-related difference in the expression and distribution of CX43 in prostate tissues. CONCLUSION AND IMPLICATIONS When gap junctional communication via CX43 was disrupted, spontaneous activity was abolished at a cellular and whole tissue level; CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland. PMID:20735413

Role of slow oscillatory activity and slow wave sleep in consolidation of episodic-like memory in rats.

PubMed

Oyanedel, Carlos N; Binder, Sonja; Kelemen, Eduard; Petersen, Kimberley; Born, Jan; Inostroza, Marion

2014-12-15

Our previous experiments showed that sleep in rats enhances consolidation of hippocampus dependent episodic-like memory, i.e. the ability to remember an event bound into specific spatio-temporal context. Here we tested the hypothesis that this enhancing effect of sleep is linked to the occurrence of slow oscillatory and spindle activity during slow wave sleep (SWS). Rats were tested on an episodic-like memory task and on three additional tasks covering separately the where (object place recognition), when (temporal memory), and what (novel object recognition) components of episodic memory. In each task, the sample phase (encoding) was followed by an 80-min retention interval that covered either a period of regular morning sleep or sleep deprivation. Memory during retrieval was tested using preferential exploration of novelty vs. familiarity. Consistent with previous findings, the rats which had slept during the retention interval showed significantly stronger episodic-like memory and spatial memory, and a trend of improved temporal memory (although not significant). Object recognition memory was similarly retained across sleep and sleep deprivation retention intervals. Recall of episodic-like memory was associated with increased slow oscillatory activity (0.85-2.0Hz) during SWS in the retention interval. Spatial memory was associated with increased proportions of SWS. Against our hypothesis, a relationship between spindle activity and episodic-like memory performance was not detected, but spindle activity was associated with object recognition memory. The results provide support for the role of SWS and slow oscillatory activity in consolidating hippocampus-dependent memory, the role of spindles in this process needs to be further examined. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

Adolescent Changes in Homeostatic Regulation of EEG Activity in the Delta and Theta Frequency Bands during NREM Sleep

PubMed Central

Campbell, Ian G.; Darchia, Nato; Higgins, Lisa M.; Dykan, Igor V.; Davis, Nicole M.; de Bie, Evan; Feinberg, Irwin

2011-01-01

Study Objectives: Slow wave EEG activity in NREM sleep decreases by more than 60% between ages 10 and 20 years. Slow wave EEG activity also declines across NREM periods (NREMPs) within a night, and this decline is thought to represent the dynamics of sleep homeostasis. We used longitudinal data to determine whether these homeostatic dynamics change across adolescence. Design: All-night sleep EEG was recorded semiannually for 6 years. Setting: EEG was recorded with ambulatory recorders in the subjects' homes. Participants: Sixty-seven subjects in 2 cohorts, one starting at age 9 and one starting at age 12 years. Measurements and Results: For NREM delta (1-4 Hz) and theta (4-8 Hz) EEG, we tested whether the proportion of spectral energy contained in the first NREMP changes with age. We also tested for age changes in the parameters of the process S exponential decline. For both delta and theta, the proportion of energy in the first NREMP declined significantly across ages 9 to 18 years. Process S parameters SWA0 and TWA0, respectively, represent slow wave (delta) activity and theta wave activity at the beginning of the night. SWA0 and TWA0 declined significantly (P < 0.0001) across ages 9 to 18. Conclusions: These declines indicate that the intensity of the homeostatic or restorative processes at the beginning of sleep diminished across adolescence. We propose that this change in sleep regulation is caused by the synaptic pruning that occurs during adolescent brain maturation. Citation: Campbell IG; Darchia N; Higgins LM; Dykan IV; Davis NM; de Bie E; Feinberg I. Adolescent changes in homeostatic regulation of EEG activity in the delta and theta frequency bands during NREM sleep. SLEEP 2011;34(1):83-91. PMID:21203377

Slow wave contraction frequency plateaus in the small intestine are composed of discrete waves of interval increase associated with dislocations.

PubMed

Parsons, Sean P; Huizinga, Jan D

2018-06-03

What is the central question of this study? What is the nature of slow wave driven contraction frequency gradients in the small intestine? What is the main finding and its importance? Frequency plateaus are composed of discrete waves of increased interval, each wave associated with a contraction dislocation. Smooth frequency gradients are generated by localised neural modulation of wave frequency, leading to functionally important wave turbulence. Both patterns are emergent properties of a network of coupled oscillators, the interstitial cells of Cajal. A gut-wide network of interstitial cells of Cajal (ICC) generate electrical oscillations (slow waves) that orchestrate waves of muscle contraction. In the small intestine there is a gradient in slow wave frequency from high at the duodenum to low at the terminal ileum. Time-averaged measurements of frequency have suggested either a smooth or stepped (plateaued) gradient. We measured individual contraction intervals from diameter maps of the mouse small intestine to create interval maps (IMaps). IMaps showed that each frequency plateau was composed of discrete waves of increased interval. Each interval wave originated at a terminating contraction wave, a "dislocation", at the plateau's proximal boundary. In a model chain of coupled phase oscillators, interval wave frequency increased as coupling decreased or as the natural frequency gradient or noise increased. Injuring the intestine at a proximal point to destroy coupling, suppressed distal steps which then reappeared with gap junction block by carbenoxolone. This lent further support to our previous hypothesis that lines of dislocations were fixed by points of low coupling strength. Dislocations induced by electrical field pulses in the intestine and by equivalent phase shift in the model, were associated with interval waves. When the enteric nervous system was active, IMaps showed a chaotic, turbulent pattern of interval change with no frequency steps or plateaus. This probably resulted from local, stochastic release of neurotransmitters. Plateaus, dislocations, interval waves and wave turbulence arise from a dynamic interplay between natural frequency and coupling in the ICC network. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak

PubMed Central

Sankaranarayanan, Rajiv; Li, Yatong; Greensmith, David J.; Eisner, David A.

2016-01-01

Key points Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca transient and slows its rate of decay.In the presence of β‐adrenergic stimulation, RyR‐mediated Ca leak produces a biphasic decay of the Ca transient with a fast early phase and a slow late phase.Two forms of Ca leak have been studied, Ca‐sensitising (induced by caffeine) and non‐sensitising (induced by ryanodine) and both induce biphasic decay of the Ca transient.Only Ca‐sensitising leak can be reversed by traditional RyR inhibitors such as tetracaine.Ca leak can also induce Ca waves. At low levels of leak, waves occur. As leak is increased, first biphasic decay and then slowed monophasic decay is seen. The level of leak has major effects on the shape of the Ca transient. Abstract In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA). We have characterised the effects of two forms of Ca leak (Ca‐sensitising and non‐sensitising) on calcium cycling and compared with those of SERCA inhibition. We measured [Ca2+]i with fluo‐3 in voltage‐clamped rat ventricular myocytes. Increasing SR leak with either caffeine (to sensitise the RyR to Ca activation) or ryanodine (non‐sensitising) had similar effects to SERCA inhibition: decreased systolic [Ca2+]i, increased diastolic [Ca2+]i and slowed decay. However, in the presence of isoproterenol, leak produced a biphasic decay of the Ca transient in the majority of cells while SERCA inhibition produced monophasic decay. Tetracaine reversed the effects of caffeine but not of ryanodine. When caffeine (1 mmol l−1) was added to a cell which displayed Ca waves, the wave frequency initially increased before waves disappeared and biphasic decay developed. Eventually (at higher caffeine concentrations), the biphasic decay was replaced by slow decay. We conclude that, in the presence of adrenergic stimulation, Ca leak can produce biphasic decay; the slow phase results from the leak opposing Ca uptake by SERCA. The degree of leak determines whether decay of Ca waves, biphasic or monophasic, occurs. PMID:26537441

Wave drift damping acting on multiple circular cylinders (model tests)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kinoshita, Takeshi; Sunahara, Shunji; Bao, W.

1995-12-31

The wave drift damping for the slow drift motion of a four-column platform is experimentally investigated. The estimation of damping force of the slow drift motion of moored floating structures in ocean waves, is one of the most important topics. Bao et al. calculated an interaction of multiple circular cylinders based on the potential flow theory, and showed that the wave drift damping is significantly influenced by the interaction between cylinders. This calculation method assumes that the slow drift motion is approximately replaced by steady current, that is, structures on slow drift motion are supposed to be equivalent to onesmore » in both regular waves and slow current. To validate semi-analytical solutions of Bao et al., experiments were carried out. At first, added resistance due to waves acting on a structure composed of multiple (four) vertical circular cylinders fixed to a slowly moving carriage, was measured in regular waves. Next, the added resistance of the structure moored by linear spring to the slowly moving carriage were measured in regular waves. Furthermore, to validate the assumption that the slow drift motion is replaced by steady current, free decay tests in still water and in regular waves were compared with the simulation of the slow drift motion using the wave drift damping coefficient obtained by the added resistance tests.« less

Biophysically Based Mathematical Modeling of Interstitial Cells of Cajal Slow Wave Activity Generated from a Discrete Unitary Potential Basis

PubMed Central

Faville, R.A.; Pullan, A.J.; Sanders, K.M.; Koh, S.D.; Lloyd, C.M.; Smith, N.P.

2009-01-01

Abstract Spontaneously rhythmic pacemaker activity produced by interstitial cells of Cajal (ICC) is the result of the entrainment of unitary potential depolarizations generated at intracellular sites termed pacemaker units. In this study, we present a mathematical modeling framework that quantitatively represents the transmembrane ion flows and intracellular Ca2+ dynamics from a single ICC operating over the physiological membrane potential range. The mathematical model presented here extends our recently developed biophysically based pacemaker unit modeling framework by including mechanisms necessary for coordinating unitary potential events, such as a T-Type Ca2+ current, Vm-dependent K+ currents, and global Ca2+ diffusion. Model simulations produce spontaneously rhythmic slow wave depolarizations with an amplitude of 65 mV at a frequency of 17.4 cpm. Our model predicts that activity at the spatial scale of the pacemaker unit is fundamental for ICC slow wave generation, and Ca2+ influx from activation of the T-Type Ca2+ current is required for unitary potential entrainment. These results suggest that intracellular Ca2+ levels, particularly in the region local to the mitochondria and endoplasmic reticulum, significantly influence pacing frequency and synchronization of pacemaker unit discharge. Moreover, numerical investigations show that our ICC model is capable of qualitatively replicating a wide range of experimental observations. PMID:19527643

Auditory closed-loop stimulation of the sleep slow oscillation enhances memory.

PubMed

Ngo, Hong-Viet V; Martinetz, Thomas; Born, Jan; Mölle, Matthias

2013-05-08

Brain rhythms regulate information processing in different states to enable learning and memory formation. The <1 Hz sleep slow oscillation hallmarks slow-wave sleep and is critical to memory consolidation. Here we show in sleeping humans that auditory stimulation in phase with the ongoing rhythmic occurrence of slow oscillation up states profoundly enhances the slow oscillation rhythm, phase-coupled spindle activity, and, consequently, the consolidation of declarative memory. Stimulation out of phase with the ongoing slow oscillation rhythm remained ineffective. Closed-loop in-phase stimulation provides a straight-forward tool to enhance sleep rhythms and their functional efficacy. Copyright © 2013 Elsevier Inc. All rights reserved.

Local sleep homeostasis in the avian brain: convergence of sleep function in mammals and birds?

PubMed

Lesku, John A; Vyssotski, Alexei L; Martinez-Gonzalez, Dolores; Wilzeck, Christiane; Rattenborg, Niels C

2011-08-22

The function of the brain activity that defines slow wave sleep (SWS) and rapid eye movement (REM) sleep in mammals is unknown. During SWS, the level of electroencephalogram slow wave activity (SWA or 0.5-4.5 Hz power density) increases and decreases as a function of prior time spent awake and asleep, respectively. Such dynamics occur in response to waking brain use, as SWA increases locally in brain regions used more extensively during prior wakefulness. Thus, SWA is thought to reflect homeostatically regulated processes potentially tied to maintaining optimal brain functioning. Interestingly, birds also engage in SWS and REM sleep, a similarity that arose via convergent evolution, as sleeping reptiles and amphibians do not show similar brain activity. Although birds deprived of sleep show global increases in SWA during subsequent sleep, it is unclear whether avian sleep is likewise regulated locally. Here, we provide, to our knowledge, the first electrophysiological evidence for local sleep homeostasis in the avian brain. After staying awake watching David Attenborough's The Life of Birds with only one eye, SWA and the slope of slow waves (a purported marker of synaptic strength) increased only in the hyperpallium--a primary visual processing region--neurologically connected to the stimulated eye. Asymmetries were specific to the hyperpallium, as the non-visual mesopallium showed a symmetric increase in SWA and wave slope. Thus, hypotheses for the function of mammalian SWS that rely on local sleep homeostasis may apply also to birds.

The occurrence of individual slow waves in sleep is predicted by heart rate

PubMed Central

Mensen, Armand; Zhang, Zhongxing; Qi, Ming; Khatami, Ramin

2016-01-01

The integration of near-infrared spectroscopy and electroencephalography measures presents an ideal method to study the haemodynamics of sleep. While the cortical dynamics and neuro-modulating influences affecting the transition from wakefulness to sleep is well researched, the assumption has been that individual slow waves, the hallmark of deep sleep, are spontaneously occurring cortical events. By creating event-related potentials from the NIRS recording, time-locked to the onset of thousands of individual slow waves, we show the onset of slow waves is phase-locked to an ongoing oscillation in the NIRS recording. This oscillation stems from the moment to moment fluctuations of light absorption caused by arterial pulsations driven by the heart beat. The same oscillating signal can be detected if the electrocardiogram is time-locked to the onset of the slow wave. The ongoing NIRS oscillation suggests that individual slow wave initiation is dependent on that signal, and not the other way round. However, the precise causal links remain speculative. We propose several potential mechanisms: that the heart-beat or arterial pulsation acts as a stimulus which evokes a down-state; local fluctuations in energy supply may lead to a network effect of hyperpolarization; that the arterial pulsations lead to corresponding changes in the cerebral-spinal-fluid which evokes the slow wave; or that a third neural generator, regulating heart rate and slow waves may be involved. PMID:27445083

An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep.

PubMed

Bjorness, Theresa E; Dale, Nicholas; Mettlach, Gabriel; Sonneborn, Alex; Sahin, Bogachan; Fienberg, Allen A; Yanagisawa, Masashi; Bibb, James A; Greene, Robert W

2016-03-30

Sleep homeostasis reflects a centrally mediated drive for sleep, which increases during waking and resolves during subsequent sleep. Here we demonstrate that mice deficient for glial adenosine kinase (AdK), the primary metabolizing enzyme for adenosine (Ado), exhibit enhanced expression of this homeostatic drive by three independent measures: (1) increased rebound of slow-wave activity; (2) increased consolidation of slow-wave sleep; and (3) increased time constant of slow-wave activity decay during an average slow-wave sleep episode, proposed and validated here as a new index for homeostatic sleep drive. Conversely, mice deficient for the neuronal adenosine A1 receptor exhibit significantly decreased sleep drive as judged by these same indices. Neuronal knock-out of AdK did not influence homeostatic sleep need. Together, these findings implicate a glial-neuronal circuit mediated by intercellular Ado, controlling expression of homeostatic sleep drive. Because AdK is tightly regulated by glial metabolic state, our findings suggest a functional link between cellular metabolism and sleep homeostasis. The work presented here provides evidence for an adenosine-mediated regulation of sleep in response to waking (i.e., homeostatic sleep need), requiring activation of neuronal adenosine A1 receptors and controlled by glial adenosine kinase. Adenosine kinase acts as a highly sensitive and important metabolic sensor of the glial ATP/ADP and AMP ratio directly controlling intracellular adenosine concentration. Glial equilibrative adenosine transporters reflect the intracellular concentration to the extracellular milieu to activate neuronal adenosine receptors. Thus, adenosine mediates a glial-neuronal circuit linking glial metabolic state to neural-expressed sleep homeostasis. This indicates a metabolically related function(s) for this glial-neuronal circuit in the buildup and resolution of our need to sleep and suggests potential therapeutic targets more directly related to sleep function. Copyright © 2016 the authors 0270-6474/16/363709-13$15.00/0.

Triggering of tremors and slow slip event in Guerrero, Mexico, by the 2010 Mw 8.8 Maule, Chile, earthquake

NASA Astrophysics Data System (ADS)

Zigone, Dimitri; Rivet, Diane; Radiguet, Mathilde; Campillo, Michel; Voisin, Christophe; Cotte, Nathalie; Walpersdorf, Andrea; Shapiro, Nikolai M.; Cougoulat, Glenn; Roux, Philippe; Kostoglodov, Vladimir; Husker, Allen; Payero, Juan S.

2012-09-01

We investigate the triggering of seismic tremor and slow slip event in Guerrero (Mexico) by the February 27, 2010 Maule earthquake (Mw 8.8). Triggered tremors start with the arrival of S wave generated by the Maule earthquake, and keep occurring during the passing of ScS, SS, Love and Rayleigh waves. The Rayleigh wave dispersion curve footprints the high frequency energy envelope of the triggered tremor, indicating a strong modulation of the source of tremors by the passing surface wave. This correlation and modulation by the passing waves is progressively lost with time over a few hours. The tremor activity continues during the weeks/months after the earthquake. GPS time series suggest that the second sub-event of the 2009-2010 SSE in Guerrero is actually triggered by the Maule earthquake. The southward displacement of the GPS stations starts coincidently with the earthquake and tremors. The long duration of tremors indicate a continuing deformation process at depth, which we propose to be the second sub-event of the 2009-2010 SSE. We show a quasi-systematic correlation between surface displacement rate measured by GPS and tremor activity, suggesting that the NVT are controlled by the variations in the slip history of the SSE. This study shows that two types of tremors emerge: (1) Those directly triggered by the passing waves and (2) those triggered by the stress variations associated with slow slip. This indicates the prominent role of aseismic creep in the Mexican subduction zone response to a large teleseismic earthquake, possibly leading to large-scale stress redistribution.

Comparisons of shear-wave slowness in the Santa Clara Valley, California using blind interpretations of data from invasive and noninvasive methods

USGS Publications Warehouse

Boore, D.M.; Asten, M.W.

2008-01-01

Many groups contributed to a blind interpretation exercise for the determination of shear-wave slowness beneath the Santa Clara Valley. The methods included invasive methods in deep boreholes as well as noninvasive methods using active and passive sources, at six sites within the valley (with most investigations being conducted at a pair of closely spaced sites near the center of the valley). Although significant variability exists between the models, the slownesses from the various methods are similar enough that linear site amplifications estimated in several ways are generally within 20% of one another. The methods were able to derive slownesses that increase systematically with distance from the valley edge, corresponding to a tendency for the sites to be underlain by finer-grained materials away from the valley edge. This variation is in agreement with measurements made in the boreholes at the sites.

[CHANGE OF CHARACTER OF INTERSYSTEMIC INTERACTIONS IN NEWBORN RAT PUPS UNDER CONDITIONS OF A DECREASE OF MOTOR ACTIVITY].

PubMed

Sizonov, V A; Dmitrieva, L E; Kuznetsov, S V

2015-01-01

Interaction of slow-wave.rhythmic components of cardiac, respiratory.and motor activity was investigated in newborn rat pups on the first day after birth under normal conditions and after pharmacological depression of spontaneous periodic motor activity (SPMA) produced by injecting myocuran (myanesin) at low (100 mg/pg, i/p) and maximal (235 mg/pg, i/p) dosages. The data obtained allow to infer that in rat pups after birth the intersystemic interactions are realized mainly via slow-wave oscillations of about-one- and many-minute ranges whereas the rhythms of decasecond range do not play a significant role in integrative processes. Injection of miocuran at a dose causing no muscle relaxation and no inhibition of motor activity produces changes of the cardiac and respiratory rhythms as well as a transitory decrease of the magnitude of coordinate relations mediated by the rhythms of about-one- and many-minute ranges. The consequences of muscle relaxant injection were found to be more significant for intersystemic interactions with participation of the respiratory system. An increase of the dosage and, correspondingly, the total inhibition of SPMA is accompanied by reduction of the slow-wave components from the pattern of cardiac and respiratory rhythms. The cardiorespiratory interactions, more expressed in intact rat pups, are reduced in the about-one- and many-minute ranges of modulation whereas in the decasecond range of modulation they are slightly increased. Key words: early ontogenesis, intersystemic interactions, cardiac rhythm, respiration, motor activity, myocuran (myanesin).

Cerebral correlates of delta waves during non-REM sleep revisited.

PubMed

Dang-Vu, Thien Thanh; Desseilles, Martin; Laureys, Steven; Degueldre, Christian; Perrin, Fabien; Phillips, Christophe; Maquet, Pierre; Peigneux, Philippe

2005-10-15

We aimed at characterizing the neural correlates of delta activity during Non Rapid Eye Movement (NREM) sleep in non-sleep-deprived normal young adults, based on the statistical analysis of a positron emission tomography (PET) sleep data set. One hundred fifteen PET scans were obtained using H(2)(15)O under continuous polygraphic monitoring during stages 2-4 of NREM sleep. Correlations between regional cerebral blood flow (rCBF) and delta power (1.5-4 Hz) spectral density were analyzed using statistical parametric mapping (SPM2). Delta power values obtained at central scalp locations negatively correlated during NREM sleep with rCBF in the ventromedial prefrontal cortex, the basal forebrain, the striatum, the anterior insula, and the precuneus. These regions embrace the set of brain areas in which rCBF decreases during slow wave sleep (SWS) as compared to Rapid Eye Movement (REM) sleep and wakefulness (Maquet, P., Degueldre, C., Delfiore, G., Aerts, J., Peters, J.M., Luxen, A., Franck, G., 1997. Functional neuroanatomy of human slow wave sleep. J. Neurosci. 17, 2807-S2812), supporting the notion that delta activity is a valuable prominent feature of NREM sleep. A strong association was observed between rCBF in the ventromedial prefrontal regions and delta power, in agreement with electrophysiological studies. In contrast to the results of a previous PET study investigating the brain correlates of delta activity (Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A.C., Jones, B.E., 1997. Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. J. Neurosci. 17, 4800-4808), in which waking scans were mixed with NREM sleep scans, no correlation was found with thalamus activity. This latter result stresses the importance of an extra-thalamic delta rhythm among the synchronous NREM sleep oscillations. Consequently, this rCBF distribution might preferentially reflect a particular modulation of the cellular processes involved in the generation of cortical delta waves during NREM sleep.

Interneuron-mediated inhibition synchronizes neuronal activity during slow oscillation.

PubMed

Chen, Jen-Yung; Chauvette, Sylvain; Skorheim, Steven; Timofeev, Igor; Bazhenov, Maxim

2012-08-15

The signature of slow-wave sleep in the electroencephalogram (EEG) is large-amplitude fluctuation of the field potential, which reflects synchronous alternation of activity and silence across cortical neurons. While initiation of the active cortical states during sleep slow oscillation has been intensively studied, the biological mechanisms which drive the network transition from an active state to silence remain poorly understood. In the current study, using a combination of in vivo electrophysiology and thalamocortical network simulation, we explored the impact of intrinsic and synaptic inhibition on state transition during sleep slow oscillation. We found that in normal physiological conditions, synaptic inhibition controls the duration and the synchrony of active state termination. The decline of interneuron-mediated inhibition led to asynchronous downward transition across the cortical network and broke the regular slow oscillation pattern. Furthermore, in both in vivo experiment and computational modelling, we revealed that when the level of synaptic inhibition was reduced significantly, it led to a recovery of synchronized oscillations in the form of seizure-like bursting activity. In this condition, the fast active state termination was mediated by intrinsic hyperpolarizing conductances. Our study highlights the significance of both intrinsic and synaptic inhibition in manipulating sleep slow rhythms.

Interneuron-mediated inhibition synchronizes neuronal activity during slow oscillation

PubMed Central

Chen, Jen-Yung; Chauvette, Sylvain; Skorheim, Steven; Timofeev, Igor; Bazhenov, Maxim

2012-01-01

The signature of slow-wave sleep in the electroencephalogram (EEG) is large-amplitude fluctuation of the field potential, which reflects synchronous alternation of activity and silence across cortical neurons. While initiation of the active cortical states during sleep slow oscillation has been intensively studied, the biological mechanisms which drive the network transition from an active state to silence remain poorly understood. In the current study, using a combination of in vivo electrophysiology and thalamocortical network simulation, we explored the impact of intrinsic and synaptic inhibition on state transition during sleep slow oscillation. We found that in normal physiological conditions, synaptic inhibition controls the duration and the synchrony of active state termination. The decline of interneuron-mediated inhibition led to asynchronous downward transition across the cortical network and broke the regular slow oscillation pattern. Furthermore, in both in vivo experiment and computational modelling, we revealed that when the level of synaptic inhibition was reduced significantly, it led to a recovery of synchronized oscillations in the form of seizure-like bursting activity. In this condition, the fast active state termination was mediated by intrinsic hyperpolarizing conductances. Our study highlights the significance of both intrinsic and synaptic inhibition in manipulating sleep slow rhythms. PMID:22641778

Comparison of shear-wave slowness profiles at 10 strong-motion sites from noninvasive SASW measurements and measurements made in boreholes

USGS Publications Warehouse

Brown, L.T.; Boore, D.M.; Stokoe, K.H.

2002-01-01

The spectral-analysis-of-surface-waves (SASW) method is a relatively new in situ method for determining shear-wave slownesses. All measurements are made on the ground surface, making it much less costly than methods that require boreholes. The SASW method uses a number of active sources (ranging from a commercial Vibroseis truck to a small handheld hammer for the study conducted here) and different receiver spacings to map a curve of apparent phase velocity versus frequency. With the simplifying assumption that the phase velocities correspond to fundamental mode surface waves, forward modeling yields an estimate of the sub-surface shear-wave slownesses. To establish the reliability of this indirect technique, we conducted a blind evaluation of the SASW method. SASW testing was performed at 10 strong-motion stations at which borehole seismic measurements were previously or subsequently made; if previously made, the borehole results were not used for the interpretation of the SASW data, and vice-versa. Comparisons of the shear-wave slownesses from the SASW and borehole measurements are generally very good. The differences in predicted ground-motion amplifications are less than about 15% for most frequencies. In addition, both methods gave the same NEHRP site classification for seven of the sites. For the other three sites the average velocities from the downhole measurements were only 5-13 m/sec larger than the velocity defining the class C/D boundary. This study demonstrates that in many situations the SASW method can provide subsurface information suitable for site response predictions.

Changes in gastric myoelectric activity during space flight

NASA Technical Reports Server (NTRS)

Harm, Deborah L.; Sandoz, Gwenn R.; Stern, Robert M.

2002-01-01

The purpose of the present study was to examine postprandial myoelectric activity of the stomach and gastric activity associated with space motion sickness using electrogastrography. Three crewmembers participated in this investigation. Preflight, subjects exhibited normal postprandial responses to the ingestion of a meal. Inflight, crewmembers exhibited an abnormal decrease in the power of the normal gastric slow wave after eating on flight day 1, but had a normal postprandial response by flight day 3. Prior to and during episodes of nausea and vomiting, the electrical activity of the stomach became dysrhythmic with 60-80% of the spectral power in the bradygastric and tachygastric frequency ranges. These findings indicate that gastric motility may be decreased during the first few days of space flight. In addition, changes in the frequency of the gastric slow wave associated with space motion sickness symptoms are consistent with those reported for laboratory-induced motion sickness.

Association between ICP pulse waveform morphology and ICP B waves.

PubMed

Kasprowicz, Magdalena; Bergsneider, Marvin; Czosnyka, Marek; Hu, Xiao

2012-01-01

The study aimed to investigate changes in the shape of ICP pulses associated with different patterns of the ICP slow waves (0.5-2.0 cycles/min) during ICP overnight monitoring in hydrocephalus. Four patterns of ICP slow waves were characterized in 44 overnight ICP recordings (no waves - NW, slow symmetrical waves - SW, slow asymmetrical waves - AS, slow waves with plateau phase - PW). The morphological clustering and analysis of ICP pulse (MOCAIP) algorithm was utilized to calculate a set of metrics describing ICP pulse morphology based on the location of three sub-peaks in an ICP pulse: systolic peak (P(1)), tidal peak (P(2)) and dicrotic peak (P(3)). Step-wise discriminant analysis was applied to select the most characteristic morphological features to distinguish between different ICP slow waves. Based on relative changes in variability of amplitudes of P(2) and P(3) we were able to distinguish between the combined groups NW + SW and AS + PW (p < 0.000001). The AS pattern can be differentiated from PW based on respective changes in the mean curvature of P(2) and P(3) (p < 0.000001); however, none of the MOCAIP feature separates between NW and SW. The investigation of ICP pulse morphology associated with different ICP B waves may provide additional information for analysing recordings of overnight ICP.

Determining attenuation properties of interfering fast and slow ultrasonic waves in cancellous bone.

PubMed

Nelson, Amber M; Hoffman, Joseph J; Anderson, Christian C; Holland, Mark R; Nagatani, Yoshiki; Mizuno, Katsunori; Matsukawa, Mami; Miller, James G

2011-10-01

Previous studies have shown that interference between fast waves and slow waves can lead to observed negative dispersion in cancellous bone. In this study, the effects of overlapping fast and slow waves on measurements of the apparent attenuation as a function of propagation distance are investigated along with methods of analysis used to determine the attenuation properties. Two methods are applied to simulated data that were generated based on experimentally acquired signals taken from a bovine specimen. The first method uses a time-domain approach that was dictated by constraints imposed by the partial overlap of fast and slow waves. The second method uses a frequency-domain log-spectral subtraction technique on the separated fast and slow waves. Applying the time-domain analysis to the broadband data yields apparent attenuation behavior that is larger in the early stages of propagation and decreases as the wave travels deeper. In contrast, performing frequency-domain analysis on the separated fast waves and slow waves results in attenuation coefficients that are independent of propagation distance. Results suggest that features arising from the analysis of overlapping two-mode data may represent an alternate explanation for the previously reported apparent dependence on propagation distance of the attenuation coefficient of cancellous bone. © 2011 Acoustical Society of America

Determining attenuation properties of interfering fast and slow ultrasonic waves in cancellous bone

PubMed Central

Nelson, Amber M.; Hoffman, Joseph J.; Anderson, Christian C.; Holland, Mark R.; Nagatani, Yoshiki; Mizuno, Katsunori; Matsukawa, Mami; Miller, James G.

2011-01-01

Previous studies have shown that interference between fast waves and slow waves can lead to observed negative dispersion in cancellous bone. In this study, the effects of overlapping fast and slow waves on measurements of the apparent attenuation as a function of propagation distance are investigated along with methods of analysis used to determine the attenuation properties. Two methods are applied to simulated data that were generated based on experimentally acquired signals taken from a bovine specimen. The first method uses a time-domain approach that was dictated by constraints imposed by the partial overlap of fast and slow waves. The second method uses a frequency-domain log-spectral subtraction technique on the separated fast and slow waves. Applying the time-domain analysis to the broadband data yields apparent attenuation behavior that is larger in the early stages of propagation and decreases as the wave travels deeper. In contrast, performing frequency-domain analysis on the separated fast waves and slow waves results in attenuation coefficients that are independent of propagation distance. Results suggest that features arising from the analysis of overlapping two-mode data may represent an alternate explanation for the previously reported apparent dependence on propagation distance of the attenuation coefficient of cancellous bone. PMID:21973378

Slow oscillations orchestrating fast oscillations and memory consolidation.

PubMed

Mölle, Matthias; Born, Jan

2011-01-01

Slow-wave sleep (SWS) facilitates the consolidation of hippocampus-dependent declarative memory. Based on the standard two-stage memory model, we propose that memory consolidation during SWS represents a process of system consolidation which is orchestrated by the neocortical <1Hz electroencephalogram (EEG) slow oscillation and involves the reactivation of newly encoded representations and their subsequent redistribution from temporary hippocampal to neocortical long-term storage sites. Indeed, experimental induction of slow oscillations during non-rapid eye movement (non-REM) sleep by slowly alternating transcranial current stimulation distinctly improves consolidation of declarative memory. The slow oscillations temporally group neuronal activity into up-states of strongly enhanced neuronal activity and down-states of neuronal silence. In a feed-forward efferent action, this grouping is induced not only in the neocortex but also in other structures relevant to consolidation, namely the thalamus generating 10-15Hz spindles, and the hippocampus generating sharp wave-ripples, with the latter well known to accompany a replay of newly encoded memories taking place in hippocampal circuitries. The feed-forward synchronizing effect of the slow oscillation enables the formation of spindle-ripple events where ripples and accompanying reactivated hippocampal memory information become nested into the single troughs of spindles. Spindle-ripple events thus enable reactivated memory-related hippocampal information to be fed back to neocortical networks in the excitable slow oscillation up-state where they can induce enduring plastic synaptic changes underlying the effective formation of long-term memories. Copyright © 2011 Elsevier B.V. All rights reserved.

Cellular mechanisms underlying spatiotemporal features of cholinergic retinal waves

PubMed Central

Ford, Kevin J.; Félix, Aude L.; Feller, Marla B.

2012-01-01

Prior to vision, a transient network of recurrently connected cholinergic interneurons, called starburst amacrine cells (SACs), generates spontaneous retinal waves. Despite an absence of robust inhibition, cholinergic retinal waves initiate infrequently and propagate within finite boundaries. Here we combine a variety of electrophysiological and imaging techniques and computational modeling to elucidate the mechanisms underlying these spatial and temporal properties of waves in developing mouse retina. Waves initiate via rare spontaneous depolarizations of SACs. Waves propagate through recurrent cholinergic connections between SACs and volume release of ACh as demonstrated using paired recordings and a cell-based ACh optical sensor. Perforated patch recordings and two-photon calcium imaging reveal that individual SACs have slow afterhyperpolarizations that induce SACs to have variable depolarizations during sequential waves. Using a computational model in which the properties of SACs are based on these physiological measurements, we reproduce the slow frequency, speed, and finite size of recorded waves. This study represents a detailed description of the circuit that mediates cholinergic retinal waves and indicates that variability of the interneurons that generate this network activity may be critical for the robustness of waves across different species and stages of development. PMID:22262883

Oscillating square wave Transcranial Direct Current Stimulation (tDCS) delivered during slow wave sleep does not improve declarative memory more than sham: A randomized sham controlled crossover study

PubMed Central

Sahlem, Gregory L.; Badran, Bashar W.; Halford, Jonathan J.; Williams, Nolan R.; Korte, Jeffrey E.; Leslie, Kimberly; Strachan, Martha; Breedlove, Jesse L.; Runion, Jennifer; Bachman, David L.; Uhde, Thomas W.; Borckardt, Jeffery J.; George, Mark S.

2015-01-01

Background A 2006 trial in healthy medical students found that anodal slow oscillating tDCS delivered bi-frontally during slow wave sleep had an enhancing effect in declarative, but not procedural memory. Although there have been supporting animal studies, and similar findings in pathological groups, this study has not been replicated, or refuted, in the intervening years. We therefore tested these earlier results for replication using similar methods with the exception of current wave form (square in our study, nearly sinusoidal in the original). Objective/Hypothesis Our objective was to test the findings of a 2006 trial suggesting bi-frontal anodal tDCS during slow wave sleep enhances declarative memory. Methods Twelve students (mean age 25, 9 women) free of medical problems underwent two testing conditions (active, sham) in a randomized counterbalanced fashion. Active stimulation consisted of oscillating square wave tDCS delivered during early Non-Rapid Eye Movement (NREM) sleep. The sham condition consisted of setting-up the tDCS device and electrodes, but not turning it on during sleep. tDCS was delivered bi-frontally with anodes placed at F3/F4, and cathodes placed at mastoids. Current density was 0.517mA/CM2, and oscillated between zero and maximal current at a frequency of 0.75Hz. Stimulation occurred during five-five minute blocks with one-minute inter-block intervals (25 minutes total stimulation). The primary outcomes were both declarative memory consolidation measured by a paired word association test (PWA), and non-declarative memory, measured by a non-dominant finger-tapping test (FTT). We also recorded and analyzed sleep EEG. Results There was no difference in the number of paired word associations remembered before compared to after sleep [(active = 3.1±3.0SD more associations) (sham = 3.8±3.1S.D more associations)]. Finger tapping improved, (non-significantly) following active stimulation [(3.6±2.7 S.D. correctly typed sequences) compared to sham stimulation (2.3± 2.2 S.D. correctly typed sequences)]. Conclusion In this study, we failed to find improvements in declarative or performance memory and could not replicate an earlier study using nearly identical settings. Specifically we failed to find a beneficial effect on either overnight declarative or non-declarative memory consolidation via square-wave oscillating tDCS intervention applied bi-frontally during early NREM sleep. It is unclear if the morphology of the tDCS pulse is critical in any memory related improvements. PMID:25795621

Conventional, Bayesian, and Modified Prony's methods for characterizing fast and slow waves in equine cancellous bone

PubMed Central

Groopman, Amber M.; Katz, Jonathan I.; Holland, Mark R.; Fujita, Fuminori; Matsukawa, Mami; Mizuno, Katsunori; Wear, Keith A.; Miller, James G.

2015-01-01

Conventional, Bayesian, and the modified least-squares Prony's plus curve-fitting (MLSP + CF) methods were applied to data acquired using 1 MHz center frequency, broadband transducers on a single equine cancellous bone specimen that was systematically shortened from 11.8 mm down to 0.5 mm for a total of 24 sample thicknesses. Due to overlapping fast and slow waves, conventional analysis methods were restricted to data from sample thicknesses ranging from 11.8 mm to 6.0 mm. In contrast, Bayesian and MLSP + CF methods successfully separated fast and slow waves and provided reliable estimates of the ultrasonic properties of fast and slow waves for sample thicknesses ranging from 11.8 mm down to 3.5 mm. Comparisons of the three methods were carried out for phase velocity at the center frequency and the slope of the attenuation coefficient for the fast and slow waves. Good agreement among the three methods was also observed for average signal loss at the center frequency. The Bayesian and MLSP + CF approaches were able to separate the fast and slow waves and provide good estimates of the fast and slow wave properties even when the two wave modes overlapped in both time and frequency domains making conventional analysis methods unreliable. PMID:26328678

[EFFECTS OF ELECTRICAL STIMULATION OF NUCLEUS RETICULARIS PONTIS ORALIS ON THE SLEEP-WAKING STATES IN KRUSHINSKII-MOLODKINA STRAIN RATS].

PubMed

Vataev, S I; Malgina, N A; Oganesyan, G A

2015-07-01

The effects of electrical stimulation of nucleus reticularis pontis oralis on the behavior and brain electrical activity during all phases of the sleep-waking cycle was studied in Krushinskii-Molodkina strain rats, which have an inherited predisposition to audiogenic seizures. Electrical stimulation with 7 Hz frequency in the deep stage of slow-wave sleep cause appearance the fast-wave sleep. Similar stimulation during fast-wave sleep periods did not effects on the electrographic patterns and EEG spectral characteristics of hippocampus, visual, auditory and somatocnen nrnrenc nf the cnrtey ThPe sfimul1stinns did nnt break a fast-wave sleenhut increased almost twice due the duration of these sleep episodes. After electrical stimulation by same frequency during the wakeftlness and superficial slow-wave sleep states, the patterns and spectral characteristics of brain electrical activity in rats showed no significant changes as compared with controls. The results of this study indicate that the state of the animals sleep-waking cycle at the time of stimulation is a critical variable that influences the responses which are induced by electrical stimulation of the nucleus reticularis pontis oralis.

Simultaneous anterior and posterior serosal mapping of gastric slow-wave dysrhythmias induced by vasopressin.

PubMed

Du, Peng; O'Grady, Gregory; Paskaranandavadivel, Niranchan; Tang, Shou-Jiang; Abell, Thomas; Cheng, Leo K

2016-06-06

What is the central question of this study? This study aimed to provide the first comparison of simultaneous high-resolution mapping of anterior and posterior gastric serosa over sustained periods. What is the main finding and its importance? Episodes of spontaneous gastric slow-wave dysrhythmias increased significantly following intravenous infusion of vasopressin compared with the baseline state. A number of persistent dysrhythmias were defined, including ectopic activation, conduction block, rotor, retrograde and collision/merger of wavefronts. Slow-wave dysrhythmias could occur either simultaneously or independently on the anterior and posterior gastric serosa, and interacted depending on activation-repolarization and frequency dynamics. High-resolution mapping enables mechanistic insights into gastric slow-wave dysrhythmias and is now achieving clinical translation. However, previous studies have focused mainly on dysrhythmias occurring on the anterior gastric wall. The present study simultaneously mapped the anterior and posterior gastric serosa during episodes of dysrhythmias induced by vasopressin to aid understanding of dysrhythmia initiation, maintenance and termination. High-resolution mapping (8 × 16 electrodes on each serosa; 20-74 cm 2 ) was performed in anaesthetized dogs. Baseline recordings (21 ± 8 min) were followed by intravenous infusion of vasopressin (0.1-0.5 IU ml -1 at 60-190 ml h -1 ) and further recordings (22 ± 13 min). Slow-wave activation maps, amplitudes, velocity, interval and frequency were calculated, and differences compared between baseline and postinfusion. All dogs demonstrated an increased prevalence of dysrhythmic events following infusion of vasopressin (17 versus 51%). Both amplitude and velocity demonstrated significant differences (baseline versus postinfusion: 3.6 versus 2.2 mV; 7.7 versus 6.5 mm s -1 ; P < 0.05 for both). Dysrhythmias occurred simultaneously or independently on the anterior and posterior serosa, and then interacted according to frequency dynamics. A number of persistent dysrhythmias were compared, including the following: ectopic activation (n = 2 animals), conduction block (n = 1), rotor (n = 2), retrograde (n = 3) and collision/merger of wavefronts (n = 2). We conclude that infusion of vasopressin induces gastric dysrhythmias, which occur across a heterogeneous range of frequencies and patterns. The results demonstrate that different classes of gastric dysrhythmias may arise simultaneously or independently in one or both surfaces of the serosa, then interact according to their relative frequencies. These results will help to inform interpretation of clinical dysrhythmia. © 2016 The Authors. Experimental Physiology © 2016 The Physiological Society.

EEG slow-wave coherence changes in propofol-induced general anesthesia: experiment and theory

PubMed Central

Wang, Kaier; Steyn-Ross, Moira L.; Steyn-Ross, D. A.; Wilson, Marcus T.; Sleigh, Jamie W.

2014-01-01

The electroencephalogram (EEG) patterns recorded during general anesthetic-induced coma are closely similar to those seen during slow-wave sleep, the deepest stage of natural sleep; both states show patterns dominated by large amplitude slow waves. Slow oscillations are believed to be important for memory consolidation during natural sleep. Tracking the emergence of slow-wave oscillations during transition to unconsciousness may help us to identify drug-induced alterations of the underlying brain state, and provide insight into the mechanisms of general anesthesia. Although cellular-based mechanisms have been proposed, the origin of the slow oscillation has not yet been unambiguously established. A recent theoretical study by Steyn-Ross et al. (2013) proposes that the slow oscillation is a network, rather than cellular phenomenon. Modeling anesthesia as a moderate reduction in gap-junction interneuronal coupling, they predict an unconscious state signposted by emergent low-frequency oscillations with chaotic dynamics in space and time. They suggest that anesthetic slow-waves arise from a competitive interaction between symmetry-breaking instabilities in space (Turing) and time (Hopf), modulated by gap-junction coupling strength. A significant prediction of their model is that EEG phase coherence will decrease as the cortex transits from Turing–Hopf balance (wake) to Hopf-dominated chaotic slow-waves (unconsciousness). Here, we investigate changes in phase coherence during induction of general anesthesia. After examining 128-channel EEG traces recorded from five volunteers undergoing propofol anesthesia, we report a significant drop in sub-delta band (0.05–1.5 Hz) slow-wave coherence between frontal, occipital, and frontal–occipital electrode pairs, with the most pronounced wake-vs.-unconscious coherence changes occurring at the frontal cortex. PMID:25400558

The role of sleep spindles and slow-wave activity in integrating new information in semantic memory.

PubMed

Tamminen, Jakke; Lambon Ralph, Matthew A; Lewis, Penelope A

2013-09-25

Assimilating new information into existing knowledge is a fundamental part of consolidating new memories and allowing them to guide behavior optimally and is vital for conceptual knowledge (semantic memory), which is accrued over many years. Sleep is important for memory consolidation, but its impact upon assimilation of new information into existing semantic knowledge has received minimal examination. Here, we examined the integration process by training human participants on novel words with meanings that fell into densely or sparsely populated areas of semantic memory in two separate sessions. Overnight sleep was polysomnographically monitored after each training session and recall was tested immediately after training, after a night of sleep, and 1 week later. Results showed that participants learned equal numbers of both word types, thus equating amount and difficulty of learning across the conditions. Measures of word recognition speed showed a disadvantage for novel words in dense semantic neighborhoods, presumably due to interference from many semantically related concepts, suggesting that the novel words had been successfully integrated into semantic memory. Most critically, semantic neighborhood density influenced sleep architecture, with participants exhibiting more sleep spindles and slow-wave activity after learning the sparse compared with the dense neighborhood words. These findings provide the first evidence that spindles and slow-wave activity mediate integration of new information into existing semantic networks.

Wave kinetics of random fibre lasers

PubMed Central

Churkin, D V.; Kolokolov, I V.; Podivilov, E V.; Vatnik, I D.; Nikulin, M A.; Vergeles, S S.; Terekhov, I S.; Lebedev, V V.; Falkovich, G.; Babin, S A.; Turitsyn, S K.

2015-01-01

Traditional wave kinetics describes the slow evolution of systems with many degrees of freedom to equilibrium via numerous weak non-linear interactions and fails for very important class of dissipative (active) optical systems with cyclic gain and losses, such as lasers with non-linear intracavity dynamics. Here we introduce a conceptually new class of cyclic wave systems, characterized by non-uniform double-scale dynamics with strong periodic changes of the energy spectrum and slow evolution from cycle to cycle to a statistically steady state. Taking a practically important example—random fibre laser—we show that a model describing such a system is close to integrable non-linear Schrödinger equation and needs a new formalism of wave kinetics, developed here. We derive a non-linear kinetic theory of the laser spectrum, generalizing the seminal linear model of Schawlow and Townes. Experimental results agree with our theory. The work has implications for describing kinetics of cyclical systems beyond photonics. PMID:25645177

What Does Ipsilateral Delay Activity Reflect? Inferences from Slow Potentials in a Lateralized Visual Working Memory Task

ERIC Educational Resources Information Center

Arend, Anna M.; Zimmer, Hubert D.

2011-01-01

In the lateralized change detection task, two item arrays are presented, one on each side of the display. Participants have to remember the items in the relevant hemifield and ignore the items in the irrelevant hemifield. A difference wave between contralateral and ipsilateral slow potentials with respect to the relevant items, the contralateral…

Traveling-Wave Maser for 32 GHz

NASA Technical Reports Server (NTRS)

Shell, James; Clauss, Robert

2009-01-01

The figure depicts a traveling-wave ruby maser that has been designed (though not yet implemented in hardware) to serve as a low-noise amplifier for reception of weak radio signals in the frequency band of 31.8 to 32.3 GHz. The design offers significant improvements over previous designs of 32-GHz traveling-wave masers. In addition, relative to prior designs of 32-GHz amplifiers based on high-electron-mobility transistors, this design affords higher immunity to radio-frequency interference and lower equivalent input noise temperature. In addition to the basic frequency-band and low-noise requirements, the initial design problem included a requirement for capability of operation in a closed-cycle helium refrigerator at a temperature .4 K and a requirement that the design be mechanically simplified, relative to prior designs, in order to minimize the cost of fabrication and assembly. Previous attempts to build 32- GHz traveling-wave masers involved the use of metallic slow-wave structures comprising coupled transverse electromagnetic (TEM)-mode resonators that were subject to very tight tolerances and, hence, were expensive to fabricate and assemble. Impedance matching for coupling signals into and out of these earlier masers was very difficult. A key feature of the design is a slow-wave structure, the metallic portions of which would be mechanically relatively simple in that, unlike in prior slow-wave structures, there would be no internal metal steps, irises, or posts. The metallic portions of the slow-wave structure would consist only of two rectangular metal waveguide arms. The arms would contain sections filled with the active material (ruby) alternating with evanescent-wave sections. This structure would be transparent in both the signal-frequency band (the aforementioned range of 31.8 to 32.3 GHz) and the pump-frequency band (65.75 to 66.75 GHz), and would impose large slowing factors in both frequency bands. Resonant ferrite isolators would be placed in the evanescent-wave sections to provide reverse loss needed to suppress reverse propagation of power at the signal frequency. This design is expected to afford a large gain-bandwidth product at the signal frequency and efficient coupling of the pump power into the paramagnetic spin resonances of the ruby sections. The more efficiently the pump power could be thus coupled, the more efficiently it could be utilized and the heat load on the refrigerator correspondingly reduced.

Teleseismic surface wave study of S-wave velocity structure in Southern California

NASA Astrophysics Data System (ADS)

Prindle-Sheldrake, K. L.; Tanimoto, T.

2002-12-01

We report on a 3D S-wave velocity structure derived from teleseismic Rayleigh and Love waves using TriNet broadband seismic data. Phase velocity maps, constructed between 20 and 55 mHz for Rayleigh waves and between 25 and 45 mHz for Love waves, were inverted for S-wave velocity structure at depth. Our starting model is SCEC 2.2, which has detailed crustal structure, but laterally homogeneous upper mantle structure. Depth resolution from the data set is good from the surface to approximately 100 km, but deteriorates rapidly beyond this depth. Our analysis indicates that, while Rayleigh wave data are mostly sensitive to mantle structure, Love wave data require some modifications of crustal structure from SCEC 2.2 model. Various regions in Southern California have different seismic-velocity signatures in terms of fast and slow S-wave velocities: In the Southern Sierra, both the crust and mantle are slow. In the Mojave desert, mid-crustal depths tend to show slow velocities, which are already built into SCEC 2.2. In the Transverse Ranges, the lower crust and mantle are both fast. Our Love wave results require much faster crustal velocity than those in SCEC 2.2 in this region. In the Peninsular ranges, both the crust and mantle are fast with mantle fast velocity extending to about 70 km. This is slightly more shallow than the depth extent under the Transverse Ranges, yet it is surprisingly deep. Under the Salton Sea, the upper crust is very slow and the upper mantle is also slow. However, these two slow velocity layers are separated by faster velocity lower crust which creates a distinct contrast with respect to the adjacent slow velocity regions. Existence of such a relatively fast layer, sandwiched by slow velocities, are related to features in phase velocity maps, especially in the low frequency Love wave phase velocity map (25 mHz) and the high frequency Rayleigh wave phase velocity maps (above 40 mHz). Such a feature may be related to partial melting processes under the Salton Sea.

Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.

PubMed

Deneke, Victoria E; Melbinger, Anna; Vergassola, Massimo; Di Talia, Stefano

2016-08-22

Embryos of most metazoans undergo rapid and synchronous cell cycles following fertilization. While diffusion is too slow for synchronization of mitosis across large spatial scales, waves of Cdk1 activity represent a possible process of synchronization. However, the mechanisms regulating Cdk1 waves during embryonic development remain poorly understood. Using biosensors of Cdk1 and Chk1 activities, we dissect the regulation of Cdk1 waves in the Drosophila syncytial blastoderm. We show that Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1. Using mathematical modeling and surgical ligations, we demonstrate a fundamental distinction between S phase Cdk1 waves, which propagate as active trigger waves in an excitable medium, and mitotic Cdk1 waves, which propagate as passive phase waves. Our findings show that in Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events. Copyright © 2016 Elsevier Inc. All rights reserved.

Photonic Crystal-Based High-Power Backward Wave Oscillator

DOE PAGES

Poole, Brian R.; Harris, John R.

2017-12-01

An electron beam traversing a slow wave structure can be used to either generate or amplify electromagnetic radiation through the interaction of the slow space charge wave on the beam with the slow wave structure modes. Here, a cylindrical waveguide with a periodic array of conducting loops is used for the slow wave structure. This paper considers operation as a backward wave oscillator. The dispersion properties of the structure are determined using a frequency-domain eigenmode solver. The interaction of the electron beam with the structure modes is investigated using a 2-D particle-in-cell (PIC) code. In conclusion, the operating frequency andmore » growth rate dependence on beam energy and beam current are investigated using the PIC code and compared with analytic and scaling estimates where possible.« less

Photonic Crystal-Based High-Power Backward Wave Oscillator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poole, Brian R.; Harris, John R.

An electron beam traversing a slow wave structure can be used to either generate or amplify electromagnetic radiation through the interaction of the slow space charge wave on the beam with the slow wave structure modes. Here, a cylindrical waveguide with a periodic array of conducting loops is used for the slow wave structure. This paper considers operation as a backward wave oscillator. The dispersion properties of the structure are determined using a frequency-domain eigenmode solver. The interaction of the electron beam with the structure modes is investigated using a 2-D particle-in-cell (PIC) code. In conclusion, the operating frequency andmore » growth rate dependence on beam energy and beam current are investigated using the PIC code and compared with analytic and scaling estimates where possible.« less

Epileptic encephalopathy with continuous spike-waves during sleep: the need for transition from childhood to adulthood medical care appears to be related to etiology.

PubMed

de Saint-Martin, Anne; Rudolf, Gabrielle; Seegmuller, Caroline; Valenti-Hirsch, Maria Paola; Hirsch, Edouard

2014-08-01

Epileptic encephalopathy with continuous diffuse spike-waves during slow-wave sleep (ECSWS) presents clinically with infrequent nocturnal focal seizures, atypical absences related to secondary bilateral synchrony, negative myoclonia, and atonic and rare generalized tonic-clonic seizures. The unique electroencephalography (EEG) pattern found in ECSWS consists of continuous, diffuse, bilateral spike-waves during slow-wave sleep. Despite the eventual disappearance of clinical seizures and EEG abnormalities by adolescence, the prognosis is guarded in most cases because of neuropsychological and behavioral deficits. ECSWS has a heterogeneous etiology (genetic, structural, and unknown). Because epilepsy and electroencephalography (EEG) abnormalities in epileptic encephalopathy with continuous diffuse spike-waves during slow-wave sleep (ECSWS) are self-limited and age related, the need for ongoing medical care and transition to adult care might be questioned. For adolescents in whom etiology remains unknown (possibly genetic) and who experience the disappearance of seizures and EEG abnormalities, there is rarely need for long-term neurologic follow-up, because often a relatively normal cognitive and social evolution follows. However, the majority of patients with structural and possibly "genetic syndromic" etiologies will have persistent cognitive deficits and will need suitable socioeducative care. Therefore, the transition process in ECSWS will depend mainly on etiology and its related features (epileptic active phase duration, and cognitive and behavioral evolution) and revolve around neuropsychological and social support rather than medical and pharmacologic follow-up. Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.

Simultaneous realization of slow and fast acoustic waves using a fractal structure of Koch curve.

PubMed

Ding, Jin; Fan, Li; Zhang, Shu-Yi; Zhang, Hui; Yu, Wei-Wei

2018-01-24

An acoustic metamaterial based on a fractal structure, the Koch curve, is designed to simultaneously realize slow and fast acoustic waves. Owing to the multiple transmitting paths in the structure resembling the Koch curve, the acoustic waves travelling along different paths interfere with each other. Therefore, slow waves are created on the basis of the resonance of a Koch-curve-shaped loop, and meanwhile, fast waves even with negative group velocities are obtained due to the destructive interference of two acoustic waves with opposite phases. Thus, the transmission of acoustic wave can be freely manipulated with the Koch-curve shaped structure.

Effect of medullary cavity in cancellous bone on two-wave phenomenon

NASA Astrophysics Data System (ADS)

Hachiken, Takuma; Nakanishi, Shoko; Matsukawa, Mami

2016-07-01

Osteoporotic patients have a larger medullary cavity in their cancellous bone than healthy people. In this study, the effect of the medullary cavity on the two-wave phenomenon was experimentally investigated using a cancellous bone model and a radius bone model. In the cancellous bone model, with the increase in hole (medullary cavity) diameter, the amplitudes of the fast waves became smaller, whereas the amplitudes of the slow waves became larger. In the radius bone model, the fast wave overlapped with the circumferential wave. The slow wave became larger with increasing hole diameter. The analysis of the slow wave thus seems to be useful for the in vivo diagnosis of the degree of osteoporosis.

Human cortical–hippocampal dialogue in wake and slow-wave sleep

PubMed Central

Mitra, Anish; Hacker, Carl D.; Pahwa, Mrinal; Tagliazucchi, Enzo; Laufs, Helmut; Leuthardt, Eric C.; Raichle, Marcus E.

2016-01-01

Declarative memory consolidation is hypothesized to require a two-stage, reciprocal cortical–hippocampal dialogue. According to this model, higher frequency signals convey information from the cortex to hippocampus during wakefulness, but in the reverse direction during slow-wave sleep (SWS). Conversely, lower-frequency activity propagates from the information “receiver” to the “sender” to coordinate the timing of information transfer. Reversal of sender/receiver roles across wake and SWS implies that higher- and lower-frequency signaling should reverse direction between the cortex and hippocampus. However, direct evidence of such a reversal has been lacking in humans. Here, we use human resting-state fMRI and electrocorticography to demonstrate that δ-band activity and infraslow activity propagate in opposite directions between the hippocampus and cerebral cortex. Moreover, both δ activity and infraslow activity reverse propagation directions between the hippocampus and cerebral cortex across wake and SWS. These findings provide direct evidence for state-dependent reversals in human cortical–hippocampal communication. PMID:27791089

Postictal psychosis and its electrophysiological correlates in invasive EEG: a case report study and literature review.

PubMed

Kuba, Robert; Brázdil, Milan; Rektor, Ivan

2012-04-01

We identified two patients with medically refractory temporal lobe epilepsy, from whom intracranial EEG recordings were obtained at the time of postictal psychosis. Both patients had mesial temporal epilepsy associated with hippocampal sclerosis. In both patients, the postictal psychosis was associated with a continual "epileptiform" EEG pattern that differed from their interictal and ictal EEG findings (rhythmical slow wave and "abortive" spike-slow wave complex activity in the right hippocampus and lateral temporal cortex in case 1 and a periodic pattern of triphasic waves in the contacts recording activity from the left anterior cingulate gyrus). Some cases of postictal psychosis might be caused by the transient impairment of several limbic system structures due to the "continual epileptiform discharge" in some brain regions. Case 2 is the first report of a patient with TLE in whom psychotic symptoms were associated with the epileptiform impairment of the anterior cingulate gyrus. Copyright © 2012 Elsevier Inc. All rights reserved.

Sensitivity of wave propagation in the LHRF to initial poloidal position in finite-aspect-ratio toroidal plasmas

NASA Astrophysics Data System (ADS)

Larson, J. J.; Pinsker, R. I.; Bonoli, P. T.; Porkolab, M.

2017-10-01

The important effect of varying the initial poloidal wave-launching location to the core accessibility of lower hybrid slow waves in a torus of finite aspect ratio has been understood for many years. Since the qualitative properties of the wave propagation of the other branch in this regime, known as the `whistler', `helicon' or simply the `fast wave', are similar in some ways to those of the slow wave, we expect a dependence on launch position for this wave also. We study this problem for both slow and fast waves, first with simplified analytic models and then using the ray-tracing code GENRAY for realistic plasma equilibria. We assess the prospects of inside, top, bottom or conventional outside launch of waves on each of the two branches. Although the slow wave has been the focus of research for LHRF heating and current drive in the past, the fast wave will play a major role in burning plasmas beyond ITER where Te(0) = 10-20 keV. The stronger electron Landau damping of the slow wave will restrict the power deposition to the outer third of the plasma, while the fast wave's weaker damping allows the wave to penetrate to the hot plasma core before depositing its power. Work supported in part by US DoE under the Science Undergraduate Laboratory Internship (SULI) program and under DE-FC02-04ER54698 and DE-FG02-91-ER54109.

Using High Speed Smartphone Cameras and Video Analysis Techniques to Teach Mechanical Wave Physics

ERIC Educational Resources Information Center

Bonato, Jacopo; Gratton, Luigi M.; Onorato, Pasquale; Oss, Stefano

2017-01-01

We propose the use of smartphone-based slow-motion video analysis techniques as a valuable tool for investigating physics concepts ruling mechanical wave propagation. The simple experimental activities presented here, suitable for both high school and undergraduate students, allows one to measure, in a simple yet rigorous way, the speed of pulses…

Modulation of electroencephalograph activity by manual acupuncture stimulation in healthy subjects: An autoregressive spectral analysis

NASA Astrophysics Data System (ADS)

Yi, Guo-Sheng; Wang, Jiang; Deng, Bin; Wei, Xi-Le; Han, Chun-Xiao

2013-02-01

To investigate whether and how manual acupuncture (MA) modulates brain activities, we design an experiment where acupuncture at acupoint ST36 of the right leg is used to obtain electroencephalograph (EEG) signals in healthy subjects. We adopt the autoregressive (AR) Burg method to estimate the power spectrum of EEG signals and analyze the relative powers in delta (0 Hz-4 Hz), theta (4 Hz-8 Hz), alpha (8 Hz-13 Hz), and beta (13 Hz-30 Hz) bands. Our results show that MA at ST36 can significantly increase the EEG slow wave relative power (delta band) and reduce the fast wave relative powers (alpha and beta bands), while there are no statistical differences in theta band relative power between different acupuncture states. In order to quantify the ratio of slow to fast wave EEG activity, we compute the power ratio index. It is found that the MA can significantly increase the power ratio index, especially in frontal and central lobes. All the results highlight the modulation of brain activities with MA and may provide potential help for the clinical use of acupuncture. The proposed quantitative method of acupuncture signals may be further used to make MA more standardized.

Uncovering representations of sleep-associated hippocampal ensemble spike activity

NASA Astrophysics Data System (ADS)

Chen, Zhe; Grosmark, Andres D.; Penagos, Hector; Wilson, Matthew A.

2016-08-01

Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remains a great challenge. In contrast to wake, during sleep there is a complete absence of animal behavior, and the ensemble spike activity is sparse (low occurrence) and fragmental in time. To examine important issues encountered in sleep data analysis, we constructed synthetic sleep-like hippocampal spike data (short epochs, sparse and sporadic firing, compressed timescale) for detailed investigations. Based upon two Bayesian population-decoding methods (one receptive field-based, and the other not), we systematically investigated their representation power and detection reliability. Notably, the receptive-field-free decoding method was found to be well-tuned for hippocampal ensemble spike data in slow wave sleep (SWS), even in the absence of prior behavioral measure or ground truth. Our results showed that in addition to the sample length, bin size, and firing rate, number of active hippocampal pyramidal neurons are critical for reliable representation of the space as well as for detection of spatiotemporal reactivated patterns in SWS or quiet wakefulness.

Acoustic Enhancement of Sleep Slow Oscillations and Concomitant Memory Improvement in Older Adults

PubMed Central

Papalambros, Nelly A.; Santostasi, Giovanni; Malkani, Roneil G.; Braun, Rosemary; Weintraub, Sandra; Paller, Ken A.; Zee, Phyllis C.

2017-01-01

Acoustic stimulation methods applied during sleep in young adults can increase slow wave activity (SWA) and improve sleep-dependent memory retention. It is unknown whether this approach enhances SWA and memory in older adults, who generally have reduced SWA compared to younger adults. Additionally, older adults are at risk for age-related cognitive impairment and therefore may benefit from non-invasive interventions. The aim of this study was to determine if acoustic stimulation can increase SWA and improve declarative memory in healthy older adults. Thirteen participants 60–84 years old completed one night of acoustic stimulation and one night of sham stimulation in random order. During sleep, a real-time algorithm using an adaptive phase-locked loop modeled the phase of endogenous slow waves in midline frontopolar electroencephalographic recordings. Pulses of pink noise were delivered when the upstate of the slow wave was predicted. Each interval of five pulses (“ON interval”) was followed by a pause of approximately equal length (“OFF interval”). SWA during the entire sleep period was similar between stimulation and sham conditions, whereas SWA and spindle activity were increased during ON intervals compared to matched periods during the sham night. The increases in SWA and spindle activity were sustained across almost the entire five-pulse ON interval compared to matched sham periods. Verbal paired-associate memory was tested before and after sleep. Overnight improvement in word recall was significantly greater with acoustic stimulation compared to sham and was correlated with changes in SWA between ON and OFF intervals. Using the phase-locked-loop method to precisely target acoustic stimulation to the upstate of sleep slow oscillations, we were able to enhance SWA and improve sleep-dependent memory storage in older adults, which strengthens the theoretical link between sleep and age-related memory integrity. PMID:28337134

Surface Current Density Mapping for Identification of Gastric Slow Wave Propagation

PubMed Central

Bradshaw, L. A.; Cheng, L. K.; Richards, W. O.; Pullan, A. J.

2009-01-01

The magnetogastrogram records clinically relevant parameters of the electrical slow wave of the stomach noninvasively. Besides slow wave frequency, gastric slow wave propagation velocity is a potentially useful clinical indicator of the state of health of gastric tissue, but it is a difficult parameter to determine from noninvasive bioelectric or biomagnetic measurements. We present a method for computing the surface current density (SCD) from multichannel magnetogastrogram recordings that allows computation of the propagation velocity of the gastric slow wave. A moving dipole source model with hypothetical as well as realistic biomagnetometer parameters demonstrates that while a relatively sparse array of magnetometer sensors is sufficient to compute a single average propagation velocity, more detailed information about spatial variations in propagation velocity requires higher density magnetometer arrays. Finally, the method is validated with simultaneous MGG and serosal EMG measurements in a porcine subject. PMID:19403355

Brain Basics: Understanding Sleep

MedlinePlus

... slow, and muscles relax even further. Your body temperature drops and eye movements stop. Brain wave activity ... functions from daily fluctuations in wakefulness to body temperature, metabolism, and the release of hormones. They control ...

Oscillating Square Wave Transcranial Direct Current Stimulation (tDCS) Delivered During Slow Wave Sleep Does Not Improve Declarative Memory More Than Sham: A Randomized Sham Controlled Crossover Study.

PubMed

Sahlem, Gregory L; Badran, Bashar W; Halford, Jonathan J; Williams, Nolan R; Korte, Jeffrey E; Leslie, Kimberly; Strachan, Martha; Breedlove, Jesse L; Runion, Jennifer; Bachman, David L; Uhde, Thomas W; Borckardt, Jeffery J; George, Mark S

2015-01-01

A 2006 trial in healthy medical students found that anodal slow oscillating tDCS delivered bi-frontally during slow wave sleep had an enhancing effect in declarative, but not procedural memory. Although there have been supporting animal studies, and similar findings in pathological groups, this study has not been replicated, or refuted, in the intervening years. We therefore tested these earlier results for replication using similar methods with the exception of current waveform (square in our study, nearly sinusoidal in the original). Our objective was to test the findings of a 2006 trial suggesting bi-frontal anodal tDCS during slow wave sleep enhances declarative memory. Twelve students (mean age 25, 9 women) free of medical problems underwent two testing conditions (active, sham) in a randomized counterbalanced fashion. Active stimulation consisted of oscillating square wave tDCS delivered during early Non-Rapid Eye Movement (NREM) sleep. The sham condition consisted of setting-up the tDCS device and electrodes, but not turning it on during sleep. tDCS was delivered bi-frontally with anodes placed at F3/F4, and cathodes placed at mastoids. Current density was 0.517 mA/cm(2), and oscillated between zero and maximal current at a frequency of 0.75 Hz. Stimulation occurred during five-five minute blocks with 1-min inter-block intervals (25 min total stimulation). The primary outcomes were both declarative memory consolidation measured by a paired word association test (PWA), and non-declarative memory, measured by a non-dominant finger-tapping test (FTT). We also recorded and analyzed sleep EEG. There was no difference in the number of paired word associations remembered before compared to after sleep [(active = 3.1 ± 3.0 SD more associations) (sham = 3.8 ± 3.1 SD more associations)]. Finger tapping improved, (non-significantly) following active stimulation [(3.6 ± 2.7 SD correctly typed sequences) compared to sham stimulation (2.3 ± 2.2 SD correctly typed sequences)]. In this study, we failed to find improvements in declarative or performance memory and could not replicate an earlier study using nearly identical settings. Specifically we failed to find a beneficial effect on either overnight declarative or non-declarative memory consolidation via square-wave oscillating tDCS intervention applied bi-frontally during early NREM sleep. It is unclear if the morphology of the tDCS pulse is critical in any memory related improvements. Copyright © 2015 Elsevier Inc. All rights reserved.

Sleep characteristics in the quail Coturnix coturnix.

PubMed

Mexicano, Graciela; Montoya-Loaiza, Bibiana; Ayala-Guerrero, Fructuoso

2014-04-22

As mammals, birds exhibit two sleep phases, slow wave sleep (SWS) and REM (Rapid Eye Movement) sleep characterized by presenting different electrophysiological patterns of brain activity. During SWS a high amplitude slow wave pattern in brain activity is observed. This activity is substituted by a low amplitude fast frequency pattern during REM sleep. Common quail (Coturnix coturnix) is an animal model that has provided information related to different physiological mechanisms present in man. There are reports related to its electrophysiological brain activity, however the sleep characteristics that have been described are not. The objectives of this study is describing the sleep characteristics throughout the nychthemeral cycle of the common quail and consider this bird species as an avian model to analyze the regulatory mechanisms of sleep. Experiments were carried out in implanted exemplars of C. coturnix. Under general anesthesia induced by ether inhalation, stainless steel electrodes were placed to register brain activity from the anterior and posterior areas during 24 continuous hours throughout the sleep-wake cycle. Ocular and motor activities were visually monitored. Quail showed four electrophysiologically and behaviorally different states of vigilance: wakefulness (53.28%), drowsiness (14.27%), slow wave sleep (30.47%) and REM sleep (1.98%). The animals presented 202 REM sleep episodes throughout the nychthemeral cycle. Sleep distribution was polyphasic; however sleep amount was significantly greater during the period corresponding to the night. The number of nocturnal REM sleep episodes was significantly greater than that of diurnal one. The quail C. coturnix shows a polyphasic distribution of sleep; however the amount of this state of vigilance is significantly greater during the nocturnal period. Copyright © 2014 Elsevier Inc. All rights reserved.

A Biologically Constrained, Mathematical Model of Cortical Wave Propagation Preceding Seizure Termination

PubMed Central

González-Ramírez, Laura R.; Ahmed, Omar J.; Cash, Sydney S.; Wayne, C. Eugene; Kramer, Mark A.

2015-01-01

Epilepsy—the condition of recurrent, unprovoked seizures—manifests in brain voltage activity with characteristic spatiotemporal patterns. These patterns include stereotyped semi-rhythmic activity produced by aggregate neuronal populations, and organized spatiotemporal phenomena, including waves. To assess these spatiotemporal patterns, we develop a mathematical model consistent with the observed neuronal population activity and determine analytically the parameter configurations that support traveling wave solutions. We then utilize high-density local field potential data recorded in vivo from human cortex preceding seizure termination from three patients to constrain the model parameters, and propose basic mechanisms that contribute to the observed traveling waves. We conclude that a relatively simple and abstract mathematical model consisting of localized interactions between excitatory cells with slow adaptation captures the quantitative features of wave propagation observed in the human local field potential preceding seizure termination. PMID:25689136

Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats.

PubMed

Lira, Fabio Santos; Esteves, Andrea Maculano; Pimentel, Gustavo Duarte; Rosa, José Cesar; Frank, Miriam Kannebley; Mariano, Melise Oliveira; Budni, Josiane; Quevedo, João; Santos, Ronaldo Vagner Dos; de Mello, Marco Túlio

2016-01-01

We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test. In the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p<0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p<0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p<0.05). Therefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity.

Shear wave velocity structure of the Anatolian Plate and surrounding regions using Ambient Noise Tomography

NASA Astrophysics Data System (ADS)

Delph, J. R.; Beck, S. L.; Zandt, G.; Biryol, C. B.; Ward, K. M.

2013-12-01

The Anatolian Plate consists of various lithospheric terranes amalgamated during the closure of the Tethys Ocean, and is currently extruding to the west in response to a combination of the collision of the Arabian plate in the east and the roll back of the Aegean subduction zone in the west. We used Ambient Noise Tomography (ANT) at periods <= 40s to investigate the crust and uppermost mantle structure of the Anatolian Plate. We computed a total of 13,779 unique cross-correlations using one sample-per-second vertical component broadband seismic data from 215 stations from 8 different networks over a period of 7 years to compute fundamental-mode Rayleigh wave dispersion curves following the method of Benson et al. (2007). We then inverted the dispersion data to calculate phase velocity maps for 11 periods from 8 s - 40 s throughout Anatolia and the Aegean regions (Barmin et al. 2001). Using smoothed Moho values derived from Vanacore et al. (2013) in our starting models, we inverted our dispersion curves using a linear least-squares iterative inversion scheme (Herrmann & Ammon 2004) to produce a 3-D shear-wave velocity model of the crust and uppermost mantle throughout Anatolia and the Aegean. We find a good correlation between our seismic shear wave velocities and paleostructures (suture zones) and modern deformation (basin formation and fault deformation). The most prominent crustal velocity contrasts occur across intercontinental sutures zones, resulting from the juxtaposition of the compositionally different basements of the amalgamated terranes. At shallow depths, seismic velocity contrasts correspond closely with surficial features. The Thrace, Cankiri and Tuz Golu basins, and accretionary complexes related to the closure of the Neotethys are characterized by slow shear wave velocities, while the Menderes and Kirsehir Massifs, Pontides, and Istanbul Zone are characterized by fast velocities. We find that the East Anatolia Plateau has slow shear-wave velocities, as expected due to high heat flow and active volcanism. The Tuz Golu fault has a visible seismic signal down to ~15 km below sea level, and the eastern Inner-Tauride Suture corresponding to the Central Anatolian Fault Zone may extend into the mantle. The Isparta Angle separates the actively extending portion of western Anatolia from the plateau regions in the east, and the largest anomaly (slow velocities) extending into the upper mantle is observed under the western flank of the Isparta Angle, corresponding to the Fethiye-Burdur fault zone. We attribute these slow shear-wave velocities to the effects of complex deformations within the crust as a result of the interactions of the African and Anatolian Plates. In the upper mantle, slow shear-wave velocities are consistent with a slab tear along a STEP fault corresponding to the extensions of the Pliny and Strabo Transform faults, allowing asthenosphere to rise to very shallow depths. The upper mantle beneath the Taurides exhibits very slow shear-wave velocities, in agreement with possible delamination or slab-breakoff (Cosentino et al. 2012) causing rapid uplift in the last 8 million years.

[Microinjections of heat shock protein 70 kDa into the nucleus reticularis pontis oralis induce inhibition of rapid eye movement sleep in pigeons].

PubMed

Gusel'nikova, E A; Pastukhov, Iu F

2008-03-01

Recently it was indicated that microinjections of heat shock proteins 70 kDa (Hsp70) into the third ventricle of brain in pigeons results in an increase in the duration of slow wave sleep and a decrease in somato-visceral indices. It is suggested that Hsp70 effect may be related to GABA(A) receptors activation in the preoptic area of the hypothalamus. However, what transmitter mechanisms of activation are related to the removal effect (in 2-3 hrs) of rapid eye movement sleep inhibition still remains poorly understood. To solve this problem in the present study, microinjections of Hsp70 into the Nucleus reticularis pontis oralis (NRPO) were done. It is well known that cholinergic neurons of the NRPO are crucial for rapid eye movement sleep generation. The data show that Hsp70 produces more early (for first two hrs) a decrease in number of episodes and total time of rapid eye movement sleep, a diminution of electroencephalogram (EEG) power spectra in the 9-14 Hz band, a decrease in contractile muscle activity and brain temperature. It is suggested that Hsp70 effects are realized due to activation of GABA(A) receptors in the NRPO and induced inhibition of cholinergic mechanisms of rapid eye movement sleep triggering. The microinjections of Hsp70 into the NRPO increase the slow wave sleep total time with long latency (for 8-12 hrs). This effect may be related to influence of Hsp70 on neurons population, which are responsible for slow wave sleep maintenance outside the NRPO.

Two Distinct Synchronization Processes in the Transition to Sleep: A High-Density Electroencephalographic Study

PubMed Central

Siclari, Francesca; Bernardi, Giulio; Riedner, Brady A.; LaRocque, Joshua J.; Benca, Ruth M.; Tononi, Giulio

2014-01-01

Objectives: To assess how the characteristics of slow waves and spindles change in the falling-asleep process. Design: Participants undergoing overnight high-density electroencephalographic recordings were awakened at 15- to 30-min intervals. One hundred forty-one falling-asleep periods were analyzed at the scalp and source level. Setting: Sleep laboratory. Participants: Six healthy participants. Interventions: Serial awakenings. Results: The number and amplitude of slow waves followed two dissociated, intersecting courses during the transition to sleep: slow wave number increased slowly at the beginning and rapidly at the end of the falling-asleep period, whereas amplitude at first increased rapidly and then decreased linearly. Most slow waves occurring early in the transition to sleep had a large amplitude, a steep slope, involved broad regions of the cortex, predominated over frontomedial regions, and preferentially originated from the sensorimotor and the posteromedial parietal cortex. Most slow waves occurring later had a smaller amplitude and slope, involved more circumscribed parts of the cortex, and had more evenly distributed origins. Spindles were initially sparse, fast, and involved few cortical regions, then became more numerous and slower, and involved more areas. Conclusions: Our results provide evidence for two types of slow waves, which follow dissociated temporal courses in the transition to sleep and have distinct cortical origins and distributions. We hypothesize that these two types of slow waves result from two distinct synchronization processes: (1) a “bottom-up,” subcorticocortical, arousal system-dependent process that predominates in the early phase and leads to type I slow waves, and (2) a “horizontal,” corticocortical synchronization process that predominates in the late phase and leads to type II slow waves. The dissociation between these two synchronization processes in time and space suggests that they may be differentially affected by experimental manipulations and sleep disorders. Citation: Siclari F, Bernardi G, Riedner BA, LaRocque JJ, Benca RM, Tononi G. Two distinct synchronization processes in the transition to sleep: a high-density electroencephalographic study. SLEEP 2014;37(10):1621-1637. PMID:25197810

[Cellular mechanism of the generation of spontaneous activity in gastric muscle].

PubMed

Nakamura, Eri; Kito, Yoshihiko; Fukuta, Hiroyasu; Yanai, Yoshimasa; Hashitani, Hikaru; Yamamoto, Yoshimichi; Suzuki, Hikaru

2004-03-01

In gastric smooth muscles, interstitial cells of Cajal (ICC) might be the pacemaker cells of spontaneous activities since ICC are rich in mitochondria and are connected with smooth muscle cells via gap junctions. Several types of ICC are distributed widely in the stomach wall. A group of ICC distributed in the myenteric layer (ICC-MY) were the pacemaker cells of gastrointestinal smooth muscles. Pacemaker potentials were generated in ICC-MY, and the potentials were conducted to circular smooth muscles to trigger slow waves and also conducted to longitudinal muscles to form follower potentials. In circular muscle preparations, interstitial cells distributed within muscle bundles (ICC-IM) produced unitary potentials, which were conducted to circular muscles to form slow potentials by summation. In mutant mice lacking inositol trisphosphate (IP(3)) receptor, slow waves were absent in gastric smooth muscles. The generation of spontaneous activity was impaired by the inhibition of Ca(2+)-release from internal stores through IP(3) receptors, inhibition of mitochondrial Ca(2+)-handling with proton pump inhibitors, and inhibition of ATP-sensitive K(+)-channels at the mitochondrial inner membrane. These results suggested that mitochondrial Ca(2+)-handling causes the generation of spontaneous activity in pacemaker cells. Possible involvement of protein kinase C (PKC) in the Ca(2+) signaling system was also suggested.

Thalamic stimulation to improve level of consciousness after seizures: evaluation of electrophysiology and behavior.

PubMed

Gummadavelli, Abhijeet; Motelow, Joshua E; Smith, Nicholas; Zhan, Qiong; Schiff, Nicholas D; Blumenfeld, Hal

2015-01-01

Understanding the neural mechanisms that support human consciousness is an important frontier in neuroscience and medicine. We previously developed a rodent model of temporal lobe seizures that recapitulates the human electroencephalography (EEG) signature of ictal and postictal neocortical slow waves associated with behavioral impairments in level of consciousness. The mechanism of slow-wave production in epilepsy may involve suppression of the subcortical arousal systems including the brainstem and intralaminar thalamic nuclei. We hypothesized that intralaminar thalamic stimulation may lead to electrophysiologic and functional rescue from postictal slow waves and behavioral arrest. We electrically stimulated the central lateral thalamic nucleus (a member of the intralaminar nuclei) under anesthesia and after electrically induced hippocampal seizures in anesthetized and in awake-behaving animal model preparations. We demonstrated a proof-of-principle restoration of electrophysiologic and behavioral measures of consciousness by stimulating the intralaminar thalamic nuclei after seizures. We measured decreased cortical slow waves and increased desynchronization and multiunit activity in the cortex with thalamic stimulation following seizures. Functionally, thalamic stimulation produced resumption of exploratory behaviors in the postictal state. Targeting of nodes in the neural circuitry of consciousness has important medical implications. Impaired consciousness with epilepsy has dangerous consequences including decreased school/work performance, social stigmatization, and impaired airway protection. These data suggest a novel therapeutic approach for restoring consciousness after seizures. If paired with responsive neurostimulation, this may allow rapid implementation to improve level of consciousness in patients with epilepsy. Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.

Exploring resting-state EEG brain oscillatory activity in relation to cognitive functioning in multiple sclerosis.

PubMed

Keune, Philipp M; Hansen, Sascha; Weber, Emily; Zapf, Franziska; Habich, Juliane; Muenssinger, Jana; Wolf, Sebastian; Schönenberg, Michael; Oschmann, Patrick

2017-09-01

Neurophysiologic monitoring parameters related to cognition in Multiple Sclerosis (MS) are sparse. Previous work reported an association between magnetoencephalographic (MEG) alpha-1 activity and information processing speed. While this remains to be replicated by more available electroencephalographic (EEG) methods, also other established EEG markers, e.g. the slow-wave/fast-wave ratio (theta/beta ratio), remain to be explored in this context. Performance on standard tests addressing information processing speed and attention (Symbol-Digit Modalities Test, SDMT; Test of Attention Performance, TAP) was examined in relation to resting-state EEG alpha-1 and alpha-2 activity and the theta/beta ratio in 25MS patients. Increased global alpha-1 and alpha-2 activity and an increased frontal theta/beta ratio (pronounced slow-wave relative to fast-wave activity) were associated with lower SDMT processing speed. In an exploratory analysis, clinically impaired attention was associated with a significantly increased frontal theta/beta ratio whereas alpha power did not show sensitivity to clinical impairment. EEG global alpha power and the frontal theta/beta ratio were both associated with attention. The theta/beta ratio involved potential clinical sensitivity. Resting-state EEG recordings can be obtained during the routine clinical process. The examined resting-state measures may represent feasible monitoring parameters in MS. This notion should be explored in future intervention studies. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Optimizing detection and analysis of slow waves in sleep EEG.

PubMed

Mensen, Armand; Riedner, Brady; Tononi, Giulio

2016-12-01

Analysis of individual slow waves in EEG recording during sleep provides both greater sensitivity and specificity compared to spectral power measures. However, parameters for detection and analysis have not been widely explored and validated. We present a new, open-source, Matlab based, toolbox for the automatic detection and analysis of slow waves; with adjustable parameter settings, as well as manual correction and exploration of the results using a multi-faceted visualization tool. We explore a large search space of parameter settings for slow wave detection and measure their effects on a selection of outcome parameters. Every choice of parameter setting had some effect on at least one outcome parameter. In general, the largest effect sizes were found when choosing the EEG reference, type of canonical waveform, and amplitude thresholding. Previously published methods accurately detect large, global waves but are conservative and miss the detection of smaller amplitude, local slow waves. The toolbox has additional benefits in terms of speed, user-interface, and visualization options to compare and contrast slow waves. The exploration of parameter settings in the toolbox highlights the importance of careful selection of detection METHODS: The sensitivity and specificity of the automated detection can be improved by manually adding or deleting entire waves and or specific channels using the toolbox visualization functions. The toolbox standardizes the detection procedure, sets the stage for reliable results and comparisons and is easy to use without previous programming experience. Copyright © 2016 Elsevier B.V. All rights reserved.

Spatio-temporal dynamics of an active, polar, viscoelastic ring.

PubMed

Marcq, Philippe

2014-04-01

Constitutive equations for a one-dimensional, active, polar, viscoelastic liquid are derived by treating the strain field as a slow hydrodynamic variable. Taking into account the couplings between strain and polarity allowed by symmetry, the hydrodynamics of an active, polar, viscoelastic body include an evolution equation for the polarity field that generalizes the damped Kuramoto-Sivashinsky equation. Beyond thresholds of the active coupling coefficients between the polarity and the stress or the strain rate, bifurcations of the homogeneous state lead first to stationary waves, then to propagating waves of the strain, stress and polarity fields. I argue that these results are relevant to living matter, and may explain rotating actomyosin rings in cells and mechanical waves in epithelial cell monolayers.

Characterization of ictal slow waves in epileptic spasms.

PubMed

Honda, Ryoko; Saito, Yoshiaki; Okumura, Akihisa; Abe, Shinpei; Saito, Takashi; Nakagawa, Eiji; Sugai, Kenji; Sasaki, Masayuki

2015-12-01

We characterized the clinico-neurophysiological features of epileptic spasms, particularly focusing on high-voltage slow waves during ictal EEG. We studied 22 patients with epileptic spasms recorded during digital video-scalp EEG, including five individuals who still had persistent spasms after callosotomy. We analysed the duration, amplitude, latency to onset of electromyographic bursts, and distribution of the highest positive and negative peaks of slow waves in 352 spasms. High-voltage positive slow waves preceded the identifiable muscle contractions of spasms. The mean duration of these positive waves was 569±228 m, and the mean latency to electromyographic onset was 182±127 m. These parameters varied markedly even within a patient. The highest peak of the positive component was distributed in variable regions, which was not consistent with the location of lesions on MRI. The peak of the negative component following the positivity was distributed in the neighbouring or opposite areas of the positive peak distribution. No changes were evident in the pre- or post-surgical distributions of the positive peak, or in the interhemispheric delay between both hemispheres, in individuals with callosotomy. Our data imply that ictal positive slow waves are the most common EEG changes during spasms associated with a massive motor component. Plausible explanations for these widespread positive slow waves include the notion that EEG changes possibly reflect involvement of both cortical and subcortical structures.

Evidence of thermal conduction depression in hot coronal loops

NASA Astrophysics Data System (ADS)

Wang, Tongjiang; Ofman, Leon; Sun, Xudong; Provornikova, Elena; Davila, Joseph

2015-08-01

Slow magnetoacoustic waves were first detected in hot (>6 MK) flare loops by the SOHO/SUMER spectrometer as Doppler shift oscillations in Fe XIX and Fe XXI lines. These oscillations are identified as standing slow-mode waves because the estimated phase speeds are close to the sound speed in the loop and some cases show a quarter period phase shift between velocity and intensity oscillations. The observed very rapid excitation and damping of standing slow mode waves have been studied by many authors using theories and numerical simulations, however, the exact mechanisms remain not well understood. Recently, flare-induced longitudinal intensity oscillations in hot post-flare loops have been detected by SDO/AIA. These oscillations have the similar physical properties as SUMER loop oscillations, and have been interpreted as the slow-mode waves. The multi-wavelength AIA observations with high spatio-temporal resolution and wide temperature coverage allow us to explore the wave excitation and damping mechanisms with an unprecedented detail to develope new coronal seismology. In this paper, we present accurate measurements of the effective adiabatic index (γeff) in the hot plasma from the electron temperature and density wave signals of a flare-induced longitudinal wave event using SDO/AIA data. Our results strikingly and clearly reveal that thermal conduction is highly depressed in hot (˜10 MK) post-flare loops and suggest that the compressive viscosity is the dominant wave damping mechanism which allows determination of the viscosity coefficient from the observables by coronal seismology. This new finding challenges our current understanding of thermal energy transport in solar and stellar flares, and may provide an alternative explanation of long-duration events and enhance our understand of coronal heating mechanism. We will discuss our results based on non-ideal MHD theory and simulations. We will also discuss the flare trigger mechanism based on magnetic topology derived from SDO/HMI vector magnetic fields using nonlinear force-free field extrapolations and discuss the wave excitation mechanism based on 3D MHD modeling of the active region.

Relationships between gastric slow wave frequency, velocity, and extracellular amplitude studied by a joint experimental-theoretical approach.

PubMed

Wang, T H-H; Du, P; Angeli, T R; Paskaranandavadivel, N; Erickson, J C; Abell, T L; Cheng, L K; O'Grady, G

2018-01-01

Gastric slow wave dysrhythmias are accompanied by deviations in frequency, velocity, and extracellular amplitude, but the inherent association between these parameters in normal activity still requires clarification. This study quantified these associations using a joint experimental-theoretical approach. Gastric pacing was conducted in pigs with simultaneous high-resolution slow wave mapping (32-256 electrodes; 4-7.6 mm spacing). Relationships between period, velocity, and amplitude were quantified and correlated for each wavefront. Human data from two existing mapping control cohorts were analyzed to extract and correlate these same parameters. A validated biophysically based ICC model was also applied in silico to quantify velocity-period relationships during entrainment simulations and velocity-amplitude relationships from membrane potential equations. Porcine pacing studies identified positive correlations for velocity-period (0.13 mm s -1 per 1 s, r 2 =.63, P<.001) and amplitude-velocity (74 μV per 1 mm s -1 , r 2 =.21, P=.002). In humans, positive correlations were also quantified for velocity-period (corpus: 0.11 mm s -1 per 1 s, r 2 =.16, P<.001; antrum: 0.23 mm s -1 per 1 s, r 2 =.55; P<.001), and amplitude-velocity (94 μV per 1 mm s -1 , r 2 =.56; P<.001). Entrainment simulations matched the experimental velocity-period relationships and demonstrated dependence on the slow wave recovery phase. Simulated membrane potential relationships were close to these experimental results (100 μV per 1 mm s -1 ). These data quantify the relationships between slow wave frequency, velocity, and extracellular amplitude. The results from both human and porcine studies were in keeping with biophysical models, demonstrating concordance with ICC biophysics. These relationships are important in the regulation of gastric motility and will help to guide interpretations of dysrhythmias. © 2017 John Wiley & Sons Ltd.

Soliton wave-speed management: Slowing, stopping, or reversing a solitary wave

NASA Astrophysics Data System (ADS)

Baines, Luke W. S.; Van Gorder, Robert A.

2018-06-01

While dispersion management is a well-known tool to control soliton properties such as shape or amplitude, far less effort has been directed toward the theoretical control of the soliton wave speed. However, recent experiments concerning the stopping or slowing of light demonstrate that the control of the soliton wave speed is of experimental interest. Motivated by these and other studies, we propose a management approach for modifying the wave speed of a soliton (or of other nonlinear wave solutions, such as periodic cnoidal waves) under the nonlinear Schrödinger equation. Making use of this approach, we are able to slow, stop, or even reverse a solitary wave, and we give several examples to bright solitons, dark solitons, and periodic wave trains, to demonstrate the method. An extension of the approach to spatially heterogeneous media, for which the wave may propagate differently at different spatial locations, is also discussed.

Cardiovascular Stress Reactivity and Carotid Intima-Media Thickness: The Buffering Role of Slow-Wave Sleep.

PubMed

Brindle, Ryan C; Duggan, Katherine A; Cribbet, Matthew R; Kline, Christopher E; Krafty, Robert T; Thayer, Julian F; Mulukutla, Suresh R; Hall, Martica H

2018-04-01

Exaggerated cardiovascular reactivity to acute psychological stress has been associated with increased carotid intima-media thickness (IMT). However, interstudy variability in this relationship suggests the presence of moderating factors. The current study aimed to test the hypothesis that poor nocturnal sleep, defined as short total sleep time or low slow-wave sleep, would moderate the relationship between cardiovascular reactivity and IMT. Participants (N = 99, 65.7% female, age = 59.3 ± 9.3 years) completed a two-night laboratory sleep study and cardiovascular examination where sleep and IMT were measured. The multisource interference task was used to induce acute psychological stress, while systolic and diastolic blood pressure and heart rate were monitored. Moderation was tested using the PROCESS framework in SPSS. Slow-wave sleep significantly moderated the relationship between all cardiovascular stress reactivity variables and IMT (all pinteraction ≤ .048, all ΔRinteraction ≥ .027). Greater stress reactivity was associated with higher IMT values in the low slow-wave sleep group and lower IMT values in the high slow-wave sleep group. No moderating effects of total sleep time were observed. The results provide evidence that nocturnal slow-wave sleep moderates the relationship between cardiovascular stress reactivity and IMT and may buffer the effect of daytime stress-related disease processes.

Effects of imatinib mesylate on the spontaneous activity generated by the guinea-pig prostate.

PubMed

Lam, Michelle; Dey, Anupa; Lang, Richard J; Exintaris, Betty

2013-08-01

What's known on the subject? and what does the study add?: Several studies have examined the functional role of tyrosine kinase receptors in the generation of spontaneous activity in various segments of the gastrointestinal and urogenital tracts through the application of its inhibitor, imatinib mesylate (Glivec®), but results are fairly inconsistent. This is the first study detailing the effects of imatinib mesylate on the spontaneous activity in the young and ageing prostate gland. As spontaneous electrical activity underlies the spontaneous rhythmic prostatic contractions that occur at rest, elucidating the mechanisms involved in the regulation of the spontaneous electrical activity and the resultant phasic contractions could conceivably lead to the identification of better targets and the development of more specific therapeutic agents to treat prostate conditions. To investigate the effect of imatinib mesylate, a tyrosine kinase receptor inhibitor, in the generation of spontaneous electrical and contractile activity in the young and ageing guinea-pig prostate. Standard tension and intracellular recording were used to measure spontaneous contractions and slow waves, respectively from the guinea-pig prostate at varying concentrations of imatinib mesylate (1-50 μm). Imatinib mesylate (1-10 μm), did not significantly affect slow waves recorded in the prostate of both age groups but at 50 μm, the amplitude of slow waves from the ageing guinea-pig prostate was significantly reduced (P < 0.05, n = 5). In contrast, the amplitude of contractions across all concentrations in the young guinea-pig prostate was reduced to between 35% and 41% of control, while the frequency was reduced to 15.7% at 1 μm (n = 7), 49.8% at 5 μm (n = 10), 46.2% at 10 μm (n = 7) and 53.1% at 50 μm (n = 5). Similarly, imatinib mesylate attenuated the amplitude and slowed the frequency of contractions in ageing guinea-pigs to 5.15% and 3.3% at 1 μm (n = 6); 21.1% and 20.8% at 5 μm (n = 8); 58.4% and 8.8% at 10 μm (n = 11); 72.7% and 60% at 50 μm (n = 5). A significant reduction in contractions but persistence of slow waves suggests imatinib mesylate may affect the smooth muscle contractile mechanism. Imatinib mesylate also significantly reduced contractions in the prostates of younger guinea pigs more than older ones, which is consistent with the notion that the younger guinea-pig prostate is more reliant on the tyrosine-dependent pacemaker ability of interstitial cells of Cajal-like prostatic interstitial cells. © 2013 The Authors BJU International © 2013 BJU International.

Estimation of fast and slow wave properties in cancellous bone using Prony's method and curve fitting.

PubMed

Wear, Keith A

2013-04-01

The presence of two longitudinal waves in poroelastic media is predicted by Biot's theory and has been confirmed experimentally in through-transmission measurements in cancellous bone. Estimation of attenuation coefficients and velocities of the two waves is challenging when the two waves overlap in time. The modified least squares Prony's (MLSP) method in conjuction with curve-fitting (MLSP + CF) is tested using simulations based on published values for fast and slow wave attenuation coefficients and velocities in cancellous bone from several studies in bovine femur, human femur, and human calcaneus. The search algorithm is accelerated by exploiting correlations among search parameters. The performance of the algorithm is evaluated as a function of signal-to-noise ratio (SNR). For a typical experimental SNR (40 dB), the root-mean-square errors (RMSEs) for one example (human femur) with fast and slow waves separated by approximately half of a pulse duration were 1 m/s (slow wave velocity), 4 m/s (fast wave velocity), 0.4 dB/cm MHz (slow wave attenuation slope), and 1.7 dB/cm MHz (fast wave attenuation slope). The MLSP + CF method is fast (requiring less than 2 s at SNR = 40 dB on a consumer-grade notebook computer) and is flexible with respect to the functional form of the parametric model for the transmission coefficient. The MLSP + CF method provides sufficient accuracy and precision for many applications such that experimental error is a greater limiting factor than estimation error.

Basilar-membrane interference patterns from multiple internal reflection of cochlear traveling waves.

PubMed

Shera, Christopher A; Cooper, Nigel P

2013-04-01

At low stimulus levels, basilar-membrane (BM) mechanical transfer functions in sensitive cochleae manifest a quasiperiodic rippling pattern in both amplitude and phase. Analysis of the responses of active cochlear models suggests that the rippling is a mechanical interference pattern created by multiple internal reflection within the cochlea. In models, the interference arises when reverse-traveling waves responsible for stimulus-frequency otoacoustic emissions (SFOAEs) reflect off the stapes on their way to the ear canal, launching a secondary forward-traveling wave that combines with the primary wave produced by the stimulus. Frequency-dependent phase differences between the two waves then create the rippling pattern measurable on the BM. Measurements of BM ripples and SFOAEs in individual chinchilla ears demonstrate that the ripples are strongly correlated with the acoustic interference pattern measured in ear-canal pressure, consistent with a common origin involving the generation of SFOAEs. In BM responses to clicks, the ripples appear as temporal fine structure in the response envelope (multiple lobes, waxing and waning). Analysis of the ripple spacing and response phase gradients provides a test for the role of fast- and slow-wave modes of reverse energy propagation within the cochlea. The data indicate that SFOAE delays are consistent with reverse slow-wave propagation but much too long to be explained by fast waves.

Traveling wave tube and method of manufacture

NASA Technical Reports Server (NTRS)

Vancil, Bernard K. (Inventor)

2004-01-01

A traveling wave tube includes a glass or other insulating envelope having a plurality of substantially parallel glass rods supported therewithin which in turn support an electron gun, a collector and an intermediate slow wave structure. The slow wave structure itself provides electrostatic focussing of a central electron beam thereby eliminating the need for focussing magnetics and materially decreasing the cost of construction as well as enabling miniaturization. The slow wave structure advantageously includes cavities along the electron beam through which the r.f. energy is propagated, or a double, interleaved ring loop structure supported by dielectric fins within a ground plane cylinder disposed coaxially within the glass envelope.

Brain extracellular glucose assessed by voltammetry throughout the rat sleep-wake cycle.

PubMed

Netchiporouk, L; Shram, N; Salvert, D; Cespuglio, R

2001-04-01

In the present study, cortical extracellular levels of glucose were monitored for the first time throughout the sleep-wake states of the freely moving rat. For this purpose, polygraphic recordings (electroencephalogram of the fronto-occipital cortices and electromyogram of the neck muscles) were achieved in combination with differential normal pulse voltammetry (DNPV) using a specific glucose sensor. Data obtained reveal that the basal extracellular glucose concentration in the conscious rat is 0.59 +/- 0.3 m M while under chloral hydrate anaesthesia (0.4 g/kg, i.p.) it increases up to 180% of its basal concentration. Regarding the sleep-wake cycle, the existence of spontaneous significant variations in the mean glucose level during slow-wave sleep (SWS = +13%) and paradoxical sleep (PS = -11%) compared with the waking state (100%) is also reported. It is to be noticed that during long periods of active waking, glucose level tends towards a decrease that becomes significant after 15 min (active waking = -32%). On the contrary, during long episodes of slow-wave sleep, it tends towards an increase which becomes significant after 12 min (SWS = +28%). It is suggested that voltammetric techniques using enzymatic biosensors are useful tools allowing direct glucose measurements in the freely moving animal. On the whole, paradoxical sleep is pointed out as a state highly dependent on the availability of energy and slow-wave sleep as a period of energy saving.

Identification of the Slow Wave of Small Bowel Myoelectrical Activity by Surface Recording

DTIC Science & Technology

2001-10-25

recording of myoelectrical activity (Fig. 1), which underlies intestinal smooth muscle contraction . In effect, the relation between intestinal mechanical...Martínez-de-Juan, J. Saiz, M. Meseguer, J.L. Ponce “Small bowel motility: relationship between smooth muscle contraction and electroenterogram signal”, Med

Receptivity of Hypersonic Boundary Layers to Distributed Roughness and Acoustic Disturbances

NASA Technical Reports Server (NTRS)

Balakumar, P.

2013-01-01

Boundary-layer receptivity and stability of Mach 6 flows over smooth and rough seven-degree half-angle sharp-tipped cones are numerically investigated. The receptivity of the boundary layer to slow acoustic disturbances, fast acoustic disturbances, and vortical disturbances is considered. The effects of three-dimensional isolated roughness on the receptivity and stability are also simulated. The results for the smooth cone show that the instability waves are generated in the leading edge region and that the boundary layer is much more receptive to slow acoustic waves than to the fast acoustic waves. Vortical disturbances also generate unstable second modes, however the receptivity coefficients are smaller than that of the slow acoustic wave. Distributed roughness elements located near the nose region decreased the receptivity of the second mode generated by the slow acoustic wave by a small amount. Roughness elements distributed across the continuous spectrum increased the receptivity of the second mode generated by the slow and fast acoustic waves and the vorticity wave. The largest increase occurred for the vorticity wave. Roughness elements distributed across the synchronization point did not change the receptivity of the second modes generated by the acoustic waves. The receptivity of the second mode generated by the vorticity wave increased in this case, but the increase is lower than that occurred with the roughness elements located across the continuous spectrum. The simulations with an isolated roughness element showed that the second mode waves generated by the acoustic disturbances are not influenced by the small roughness element. Due to the interaction, a three-dimensional wave is generated. However, the amplitude is orders of magnitude smaller than the two-dimensional wave.

Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.

PubMed

González-Rueda, Ana; Pedrosa, Victor; Feord, Rachael C; Clopath, Claudia; Paulsen, Ole

2018-03-21

Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic homeostasis hypothesis suggests that synaptic connections are strengthened during wake and downscaled during sleep; however, it is not obvious how the same plasticity rules could explain both outcomes. Using whole-cell recordings and optogenetic stimulation of presynaptic input in urethane-anesthetized mice, which exhibit slow-wave-sleep (SWS)-like activity, we show that synaptic plasticity rules are gated by cortical dynamics in vivo. While Down states support conventional spike timing-dependent plasticity, Up states are biased toward depression such that presynaptic stimulation alone leads to synaptic depression, while connections contributing to postsynaptic spiking are protected against this synaptic weakening. We find that this novel activity-dependent and input-specific downscaling mechanism has two important computational advantages: (1) improved signal-to-noise ratio, and (2) preservation of previously stored information. Thus, these synaptic plasticity rules provide an attractive mechanism for SWS-related synaptic downscaling and circuit refinement. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Slow waves, sharp waves, ripples, and REM in sleeping dragons.

PubMed

Shein-Idelson, Mark; Ondracek, Janie M; Liaw, Hua-Peng; Reiter, Sam; Laurent, Gilles

2016-04-29

Sleep has been described in animals ranging from worms to humans. Yet the electrophysiological characteristics of brain sleep, such as slow-wave (SW) and rapid eye movement (REM) activities, are thought to be restricted to mammals and birds. Recording from the brain of a lizard, the Australian dragon Pogona vitticeps, we identified SW and REM sleep patterns, thus pushing back the probable evolution of these dynamics at least to the emergence of amniotes. The SW and REM sleep patterns that we observed in lizards oscillated continuously for 6 to 10 hours with a period of ~80 seconds. The networks controlling SW-REM antagonism in amniotes may thus originate from a common, ancient oscillator circuit. Lizard SW dynamics closely resemble those observed in rodent hippocampal CA1, yet they originate from a brain area, the dorsal ventricular ridge, that has no obvious hodological similarity with the mammalian hippocampus. Copyright © 2016, American Association for the Advancement of Science.

Cycle-Triggered Cortical Stimulation during Slow Wave Sleep Facilitates Learning a BMI Task: A Case Report in a Non-Human Primate

PubMed Central

Rembado, Irene; Zanos, Stavros; Fetz, Eberhard E.

2017-01-01

Slow wave sleep (SWS) has been identified as the sleep stage involved in consolidating newly acquired information. A growing body of evidence has shown that delta (1–4 Hz) oscillatory activity, the characteristic electroencephalographic signature of SWS, is involved in coordinating interaction between the hippocampus and the neocortex and is thought to take a role in stabilizing memory traces related to a novel task. This case report describes a new protocol that uses neuroprosthetics training of a non-human primate to evaluate the effects of surface cortical electrical stimulation triggered from SWS cycles. The results suggest that stimulation phase-locked to SWS oscillatory activity promoted learning of the neuroprosthetic task. This protocol could be used to elucidate mechanisms of synaptic plasticity underlying off-line learning during sleep and offers new insights into the role of brain oscillations in information processing and memory consolidation. PMID:28450831

Altered slow wave activity in major depressive disorder with hypersomnia: a high density EEG pilot study

PubMed Central

Plante, David T.; Landsness, Eric C.; Peterson, Michael J.; Goldstein, Michael R.; Wanger, Tim; Guokas, Jeff J.; Tononi, Giulio; Benca, Ruth M.

2012-01-01

Hypersomnolence in major depressive disorder (MDD) plays an important role in the natural history of the disorder, but the basis of hypersomnia in MDD is poorly understood. Slow wave activity (SWA) has been associated with sleep homeostasis, as well as sleep restoration and maintenance, and may be altered in MDD. Therefore, we conducted a post-hoc study that utilized high density electroencephalography (hdEEG) to test the hypothesis that MDD subjects with hypersomnia (HYS+) would have decreased SWA relative to age and sex-matched MDD subjects without hypersomnia (HYS−) and healthy controls (n=7 for each group). After correcting for multiple comparisons using statistical non-parametric mapping, HYS+ subjects demonstrated significantly reduced parieto-occipital all-night SWA relative to HYS− subjects. Our results suggest hypersomnolence may be associated with topographic reductions in SWA in MDD. Further research using adequately powered prospective design is indicated to confirm these findings. PMID:22512951

Prefrontal atrophy, disrupted NREM slow waves, and impaired hippocampal-dependent memory in aging

PubMed Central

Mander, Bryce A.; Rao, Vikram; Lu, Brandon; Saletin, Jared M.; Lindquist, John R.; Ancoli-Israel, Sonia; Jagust, William; Walker, Matthew P.

2014-01-01

Aging has independently been associated with regional brain atrophy, reduced non-rapid eye movement (NREM) slow-wave activity (SWA), and impaired long-term retention of episodic memories. However, that the interaction of these factors represents a neuropatholgical pathway associated with cognitive decline in later life remains unknown. Here, we show that age-related medial prefrontal cortex (mPFC) grey-matter atrophy is associated with reduced NREM SWA activity in older adults, the extent to which statistically mediates the impairment of overnight sleep-dependent memory retention. Moreover, this memory impairment was further associated with persistent hippocampal activation and reduced task-related hippocampal-prefrontal cortex connectivity, potentially representing impoverished hippocampal-neocortical memory transformation. Together, these data support a model in which age-related mPFC atrophy diminishes SWA, the functional consequence of which is impaired long-term memory. Such findings suggest that sleep disruption in the elderly, mediated by structural brain changes, represent a novel contributing factor to age-related cognitive decline in later life. PMID:23354332

Using COMSOL Multiphysics Software to Model Anisotropic Dielectric and Metamaterial Effects in Folded-Waveguide Traveling-Wave Tube Slow-Wave Circuits

NASA Technical Reports Server (NTRS)

Starinshak, David P.; Smith, Nathan D.; Wilson, Jeffrey D.

2008-01-01

The electromagnetic effects of conventional dielectrics, anisotropic dielectrics, and metamaterials were modeled in a terahertz-frequency folded-waveguide slow-wave circuit. Results of attempts to utilize these materials to increase efficiency are presented.

Giant amplification in degenerate band edge slow-wave structures interacting with an electron beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Othman, Mohamed A. K.; Veysi, Mehdi; Capolino, Filippo

2016-03-15

We propose a new amplification regime based on a synchronous operation of four degenerate electromagnetic (EM) modes in a slow-wave structure and the electron beam, referred to as super synchronization. These four EM modes arise in a Fabry-Pérot cavity when degenerate band edge (DBE) condition is satisfied. The modes interact constructively with the electron beam resulting in superior amplification. In particular, much larger gains are achieved for smaller beam currents compared to conventional structures based on synchronization with only a single EM mode. We demonstrate giant gain scaling with respect to the length of the slow-wave structure compared to conventionalmore » Pierce type single mode traveling wave tube amplifiers. We construct a coupled transmission line model for a loaded waveguide slow-wave structure exhibiting a DBE, and investigate the phenomenon of giant gain via super synchronization using the Pierce model generalized to multimode interaction.« less

Using high speed smartphone cameras and video analysis techniques to teach mechanical wave physics

NASA Astrophysics Data System (ADS)

Bonato, Jacopo; Gratton, Luigi M.; Onorato, Pasquale; Oss, Stefano

2017-07-01

We propose the use of smartphone-based slow-motion video analysis techniques as a valuable tool for investigating physics concepts ruling mechanical wave propagation. The simple experimental activities presented here, suitable for both high school and undergraduate students, allows one to measure, in a simple yet rigorous way, the speed of pulses along a spring and the period of transverse standing waves generated in the same spring. These experiments can be helpful in addressing several relevant concepts about the physics of mechanical waves and in overcoming some of the typical student misconceptions in this same field.

Alfvén wave dynamics at the neighborhood of a 2.5D magnetic null-point

NASA Astrophysics Data System (ADS)

Sabri, S.; Vasheghani Farahani, S.; Ebadi, H.; Hosseinpour, M.; Fazel, Z.

2018-05-01

The aim of the present study is to highlight the energy transfer via the interaction of magnetohydrodynamic waves with a 2.5D magnetic null-point in a finite plasma-β regime of the solar corona. An initially symmetric Alfvén pulse at a specific distance from a magnetic null-point is kicked towards the isothermal null-point. A shock-capturing Godunov-type PLUTO code is used to solve the ideal magnetohydrodynamic set equations in the context of wave-plasma energy transfer. As the Alfvén wave propagates towards the magnetic null-point it experiences speed lowering which ends up in releasing energy along the separatrices. In this line owing to the Alfvén wave, a series of events take place that contribute towards coronal heating. Nonlinear induced waves are by products of the torsional Alfvén interaction with magnetic null-points. The energy of these induced waves which are fast magnetoacoustic (transverse) and slow magnetoacoustic (longitudinal) waves are supplied by the Alfvén wave. The nonlinearly induced density perturbations are proportional to the Alfvén wave energy loss. This supplies energy for the propagation of fast and slow magnetoacoustic waves, where in contrast to the fast wave the slow wave experiences a continuous energy increase. As such, the slow wave may transfer its energy to the medium at later times, maintaining a continuous heating mechanism at the neighborhood of a magnetic null-point.

KINETIC SIMULATION OF SLOW MAGNETOSONIC WAVES AND QUASI-PERIODIC UPFLOWS IN THE SOLAR CORONA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruan, Wenzhi; He, Jiansen; Tu, Chuanyi

Quasi-periodic disturbances of emission-line parameters are frequently observed in the corona. These disturbances propagate upward along the magnetic field with speeds of ∼100 km s{sup −1}. This phenomenon has been interpreted as evidence of the propagation of slow magnetosonic waves or has been argued to be a signature of intermittent outflows superposed on the background plasmas. Here we aim to present a new “wave + flow” model to interpret these observations. In our scenario, the oscillatory motion is a slow-mode wave, and the flow is associated with a beam created by the wave–particle interaction owing to Landau resonance. With themore » help of a kinetic model, we simulate the propagation of slow-mode waves and the generation of beam flows. We find that weak periodic beam flows can be generated by to Landau resonance in the solar corona, and the phase with the strongest blueward asymmetry is ahead of that with the strongest blueshift by about 1/4 period. We also find that the slow wave damps to the level of 1/ e after the transit time of two wave periods, owing to Landau damping and Coulomb collisions in our simulation. This damping timescale is similar to that resulting from thermal conduction in the MHD regime. The beam flow is weakened/attenuated with increasing wave period and decreasing wave amplitude since Coulomb collisions become more and more dominant over the wave action. We suggest that this “wave + flow” kinetic model provides an alternative explanation for the observed quasi-periodic propagating perturbations in various parameters in the solar corona.« less

Influence of general anaesthesia on slow waves of intracranial pressure.

PubMed

Lalou, Despina A; Czosnyka, Marek; Donnelly, Joseph; Lavinio, Andrea; Pickard, John D; Garnett, Matthew; Czosnyka, Zofia

2016-07-01

Slow vasogenic intracranial pressure (ICP) waves are spontaneous ICP oscillations with a low frequency bandwidth of 0.3-4 cycles/min (B-waves). B-waves reflect dynamic oscillations in cerebral blood volume associated with autoregulatory cerebral vasodilation and vasoconstriction. This study quantifies the effects of general anaesthesia (GA) on the magnitude of B-waves compared to natural sleep and conscious state. The magnitude of B-waves was assessed in 4 groups of 30 patients each with clinical indications for ICP monitoring. Normal pressure hydrocephalus patients undergoing Cerebrospinal Fluid (CSF) infusion studies in the conscious state (GROUP A) and under GA (GROUP B), and hydrocephalus patients undergoing overnight ICP monitoring during physiological sleep (GROUP C) were compared to deeply sedated traumatic brain injury (TBI) patients with well-controlled ICP during the first night of Intensive Care Unit (ICU) stay (GROUP D). A total of 120 patients were included. During CSF infusion studies, the magnitude of slow waves was higher in conscious patients ( 0.23+/-0.10 mm Hg) when compared to anaesthetised patients ( 0.15+/-0.10 mm Hg; p = 0.011). Overnight magnitude of slow waves was higher in patients during natural sleep (GROUP C: 0.20+/-0.13 mm Hg) when compared to TBI patients under deep sedation (GROUP D: 0.11+/- 0.09 mm Hg; p = 0.002). GA and deep sedation are associated with a reduced magnitude of B-waves. ICP monitoring carried out under GA is affected by iatrogenic suppression of slow vasogenic waves of ICP. Accounting for the effects of anaesthesia on vasogenic waves may prevent the misidentification of potential shunt-responders as non-responders.

Preoperative EEG predicts memory and selective cognitive functions after temporal lobe surgery.

PubMed Central

Tuunainen, A; Nousiainen, U; Hurskainen, H; Leinonen, E; Pilke, A; Mervaala, E; Vapalahti, M; Partanen, J; Riekkinen, P

1995-01-01

Preoperative and postoperative cognitive and memory functions, psychiatric outcome, and EEGs were evaluated in 32 epileptic patients who underwent temporal lobe surgery. The presence and location of preoperative slow wave focus in routine EEG predicted memory functions of the non-resected side after surgery. Neuropsychological tests of the function of the frontal lobes also showed improvement. Moreover, psychiatric ratings showed that seizure free patients had significantly less affective symptoms postoperatively than those who were still exhibiting seizures. After temporal lobectomies, successful outcome in postoperative memory functions can be achieved in patients with unilateral slow wave activity in preoperative EEGs. This study suggests a new role for routine EEG in preoperative evaluation of patients with temporal lobe epilepsy. PMID:7608663

Double shock front formation in cylindrical radiative blast waves produced by laser irradiation of krypton gas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, I.; Quevedo, H. J.; Feldman, S.

2013-12-15

Radiative blast waves were created by irradiating a krypton cluster source from a supersonic jet with a high intensity femtosecond laser pulse. It was found that the radiation from the shock surface is absorbed in the optically thick upstream medium creating a radiative heat wave that travels supersonically ahead of the main shock. As the blast wave propagates into the heated medium, it slows and loses energy, and the radiative heat wave also slows down. When the radiative heat wave slows down to the transonic regime, a secondary shock in the ionization precursor is produced. This paper presents experimental datamore » characterizing both the initial and secondary shocks and numerical simulations to analyze the double-shock dynamics.« less

Plasma production by helicon and slow waves.

PubMed

Sakawa, Youichi; Kunimatsu, Hiroyuki; Kikuchi, Hideki; Fukui, Yasuaki; Shoji, Tatsuo

2003-03-14

The observation of slow-wave sustained (SW) discharge in a whistler- or helicon-wave range of frequency is made using high-frequency and very-high-frequency bands of rf. The SW discharge occurs at an extremely low rf power and plasma density, which are lower than a capacitive-coupling discharge region.

Cancellous bone analysis with modified least squares Prony's method and chirp filter: phantom experiments and simulation.

PubMed

Wear, Keith A

2010-10-01

The presence of two longitudinal waves in porous media is predicted by Biot's theory and has been confirmed experimentally in cancellous bone. When cancellous bone samples are interrogated in through-transmission, these two waves can overlap in time. Previously, the Modified Least-Squares Prony's (MLSP) method was validated for estimation of amplitudes, attenuation coefficients, and phase velocities of fast and slow waves, but tended to overestimate phase velocities by up to about 5%. In the present paper, a pre-processing chirp filter to mitigate the phase velocity bias is derived. The MLSP/chirp filter (MLSPCF) method was tested for decomposition of a 500 kHz-center-frequency signal containing two overlapping components: one passing through a low-density-polyethylene plate (fast wave) and another passing through a cancellous-bone-mimicking phantom material (slow wave). The chirp filter reduced phase velocity bias from 100 m/s (5.1%) to 69 m/s (3.5%) (fast wave) and from 29 m/s (1.9%) to 10 m/s (0.7%) (slow wave). Similar improvements were found for 1) measurements in polycarbonate (fast wave) and a cancellous-bone-mimicking phantom (slow wave), and 2) a simulation based on parameters mimicking bovine cancellous bone. The MLSPCF method did not offer consistent improvement in estimates of attenuation coefficient or amplitude.

Advances in wave turbulence: rapidly rotating flows

NASA Astrophysics Data System (ADS)

Cambon, C.; Rubinstein, R.; Godeferd, F. S.

2004-07-01

At asymptotically high rotation rates, rotating turbulence can be described as a field of interacting dispersive waves by the general theory of weak wave turbulence. However, rotating turbulence has some complicating features, including the anisotropy of the wave dispersion relation and the vanishing of the wave frequency on a non-vanishing set of 'slow' modes. These features prevent straightforward application of existing theories and lead to some interesting properties, including the transfer of energy towards the slow modes. This transfer competes with, and might even replace, the transfer to small scales envisioned in standard turbulence theories. In this paper, anisotropic spectra for rotating turbulence are proposed based on weak turbulence theory; some evidence for their existence is given based on numerical calculations of the wave turbulence equations. Previous arguments based on the properties of resonant wave interactions suggest that the slow modes decouple from the others. Here, an extended wave turbulence theory with non-resonant interactions is proposed in which all modes are coupled; these interactions are possible only because of the anisotropy of the dispersion relation. Finally, the vanishing of the wave frequency on the slow modes implies that these modes cannot be described by weak turbulence theory. A more comprehensive approach to rotating turbulence is proposed to overcome this limitation.

A distinctive subpopulation of medial septal slow-firing neurons promote hippocampal activation and theta oscillations

PubMed Central

Lin, Shih-Chieh; Nicolelis, Miguel A. L.

2011-01-01

The medial septum-vertical limb of the diagonal band of Broca (MSvDB) is important for normal hippocampal functions and theta oscillations. Although many previous studies have focused on understanding how MSVDB neurons fire rhythmic bursts to pace hippocampal theta oscillations, a significant portion of MSVDB neurons are slow-firing and thus do not pace theta oscillations. The function of these MSVDB neurons, especially their role in modulating hippocampal activity, remains unknown. We recorded MSVDB neuronal ensembles in behaving rats, and identified a distinct physiologically homogeneous subpopulation of slow-firing neurons (overall firing <4 Hz) that shared three features: 1) much higher firing rate during rapid eye movement sleep than during slow-wave (SW) sleep; 2) temporary activation associated with transient arousals during SW sleep; 3) brief responses (latency 15∼30 ms) to auditory stimuli. Analysis of the fine temporal relationship of their spiking and theta oscillations showed that unlike the theta-pacing neurons, the firing of these “pro-arousal” neurons follows theta oscillations. However, their activity precedes short-term increases in hippocampal oscillation power in the theta and gamma range lasting for a few seconds. Together, these results suggest that these pro-arousal slow-firing MSvDB neurons may function collectively to promote hippocampal activation. PMID:21865435

Comparing the Robustness of High-Frequency Traveling-Wave Tube Slow-Wave Circuits

NASA Technical Reports Server (NTRS)

Chevalier, Christine T.; Wilson, Jeffrey D.; Kory, Carol L.

2007-01-01

A three-dimensional electromagnetic field simulation software package was used to compute the cold-test parameters, phase velocity, on-axis interaction impedance, and attenuation, for several high-frequency traveling-wave tube slow-wave circuit geometries. This research effort determined the effects of variations in circuit dimensions on cold-test performance. The parameter variations were based on the tolerances of conventional micromachining techniques.

The new wave-ring helical (WRH) slow-wave structure for traveling wave tube amplifiers

NASA Astrophysics Data System (ADS)

Panahi, Nasser; Saviz, S.; Ghorannevis, M.

2017-12-01

In this paper, the new slow-wave structure called wave-ring helix to enhance the power of the traveling wave tubes is introduced. In this new structure, without increasing the length and radius of the helix, the wave motion path can be increased to radiofrequency wave in phase with the electron beam. The results show that in the special frequency range the output power and gain are greater than conventional helix. In this paper, optimization results are presented in cold and hot tests on the new structure. The software CST is used in S-band frequency range.

Output characteristics of a 0.14 THz dual sheet beam backward wave oscillator based on a hole-grating slow wave structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, Xiaopin; Yang, Ziqiang; Shi, Zongjun

A novel backward wave oscillator (BWO) based on a hole-grating slow wave structure is proposed as a dual sheet beam millimeter wave radiation source. In this paper, we focus on the output characteristics of a 0.14 THz hole-grating BWO. The output characteristics of the hole-grating BWO, the conventional single-beam grating BWO, and the dual-beam grating BWO are contrasted in detail. 3-D particle-in-cell results indicate that the hole-grating slow wave structure can help to increase the maximum output power as well as lower the operating current density. Meanwhile, the hole-grating BWO shows good insensitivity to the differences between two sheet electronmore » beams. These characteristics make the hole-grating BWO feasible to be a stable millimeter wave radiation source with higher output power.« less

Linearized traveling wave amplifier with hard limiter characteristics

NASA Technical Reports Server (NTRS)

Kosmahl, H. G. (Inventor)

1986-01-01

A dynamic velocity taper is provided for a traveling wave tube with increased linearity to avoid intermodulation of signals being amplified. In a traveling wave tube, the slow wave structure is a helix including a sever. A dynamic velocity taper is provided by gradually reducing the spacing between the repeating elements of the slow wave structure which are the windings of the helix. The reduction which takes place coincides with the ouput point of helix. The spacing between the repeating elements of the slow wave structure is ideally at an exponential rate because the curve increases the point of maximum efficiency and power, at an exponential rate. A coupled cavity traveling wave tube having cavities is shown. The space between apertured discs is gradually reduced from 0.1% to 5% at an exponential rate. Output power (or efficiency) versus input power for a commercial tube is shown.

Shock Formation and Energy Dissipation of Slow Magnetosonic Waves in Coronal Plumes

NASA Technical Reports Server (NTRS)

Cuntz, M.; Suess, S. T.

2003-01-01

We study the shock formation and energy dissipation of slow magnetosonic waves in coronal plumes. The wave parameters and the spreading function of the plumes as well as the base magnetic field strength are given by empirical constraints mostly from SOHO/UVCS. Our models show that shock formation occurs at low coronal heights, i.e., within 1.3 bun, depending on the model parameters. In addition, following analytical estimates, we show that scale height of energy dissipation by the shocks ranges between 0.15 and 0.45 Rsun. This implies that shock heating by slow magnetosonic waves is relevant at most heights, even though this type of waves is apparently not a solely operating energy supply mechanism.

Three-Dimensional Simulation of Traveling-Wave Tube Cold-Test Characteristics Using MAFIA

NASA Technical Reports Server (NTRS)

Kory, Carol L.; Wilson, Jeffrey D.

1995-01-01

The three-dimensional simulation code MAFIA was used to compute the cold-test parameters - frequency-phase dispersion, beam on-axis interaction impedance, and attenuation - for two types of traveling-wave tube (TWT) slow-wave circuits. The potential for this electromagnetic computer modeling code to reduce the time and cost of TWT development is demonstrated by the high degree of accuracy achieved in calculating these parameters. Generalized input files were developed for ferruled coupled-cavity and TunneLadder slow-wave circuits. These files make it easy to model circuits of arbitrary dimensions. The utility of these files was tested by applying each to a specific TWT slow-wave circuit and comparing the results with experimental data. Excellent agreement was obtained.

Generalized three-dimensional simulation of ferruled coupled-cavity traveling-wave-tube dispersion and impedance characteristics

NASA Technical Reports Server (NTRS)

Maruschek, Joseph W.; Kory, Carol L.; Wilson, Jeffrey D.

1993-01-01

The frequency-phase dispersion and Pierce on-axis interaction impedance of a ferruled, coupled-cavity, traveling-wave tube (TWT), slow-wave circuit were calculated using the three-dimensional simulation code Micro-SOS. The utilization of the code to reduce costly and time-consuming experimental cold tests is demonstrated by the accuracy achieved in calculating these parameters. A generalized input file was developed so that ferruled coupled-cavity TWT slow-wave circuits of arbitrary dimensions could be easily modeled. The practicality of the generalized input file was tested by applying it to the ferruled coupled-cavity slow-wave circuit of the Hughes Aircraft Company model 961HA TWT and by comparing the results with experimental results.

Accurate Cold-Test Model of Helical TWT Slow-Wave Circuits

NASA Technical Reports Server (NTRS)

Kory, Carol L.; Dayton, James A., Jr.

1997-01-01

Recently, a method has been established to accurately calculate cold-test data for helical slow-wave structures using the three-dimensional electromagnetic computer code, MAFIA. Cold-test parameters have been calculated for several helical traveling-wave tube (TWT) slow-wave circuits possessing various support rod configurations, and results are presented here showing excellent agreement with experiment. The helical models include tape thickness, dielectric support shapes and material properties consistent with the actual circuits. The cold-test data from this helical model can be used as input into large-signal helical TWT interaction codes making it possible, for the first time, to design a complete TWT via computer simulation.

Medical management with diazepam for electrical status epilepticus during slow wave sleep in children.

PubMed

Francois, Densley; Roberts, Jessica; Hess, Stephany; Probst, Luke; Eksioglu, Yaman

2014-03-01

Oral diazepam, administered in varying doses, is among the few proposed treatment options for electrical status epilepticus during slow wave sleep in children. We sought to retrospectively evaluate the long-term efficacy of high-dose oral diazepam in reducing electrographic and clinical evidence of electrical status epilepticus during slow wave sleep in children. Additionally, we surveyed caregivers to assess safety and behavioral outcomes related to ongoing therapy. We collected demographic and clinical data on children treated for electrical status epilepticus during slow wave sleep between October 2010 and March 2013. We sought to identify the number of patients who achieved at least a 50% reduction in spike wave index on electroencephalograph after receiving high-dose oral diazepam. We also administered a questionnaire to caregivers to assess for behavioral problems and side effects. We identified 42 evaluable patients who received high-dose diazepam (range 0.23-2.02 mg/kg per day) to treat electrical status epilepticus during slow wave sleep. Twenty-six patients had spike reduction data and 18/26 (69.2%) children achieved a greater than 50% reduction in spike wave count from an average of 15.54 to 5.05 (P = 0.001). We received 28 responses to the questionnaire. Some patients experienced new onset of difficulties with problem-solving and speech and writing development. Sleep disturbances (50%) and irritability (57.1%) were the most frequent side effects reported. There did not appear to be a dose-related effect with electroencephalograph changes, behavioral effects, or side effects. High-dose oral diazepam significantly reduces the spike wave count on electroencephalograph in children with electrical status epilepticus during slow wave sleep. Although this therapy improves electroencephalograph-related findings, it can be associated with concerning neurological and behavioral side effects in some individuals, so further study is warranted. Copyright © 2014 Elsevier Inc. All rights reserved.

Intracochlear Scala Media Pressure Measurement: Implications for Models of Cochlear Mechanics.

PubMed

Kale, Sushrut S; Olson, Elizabeth S

2015-12-15

Models of the active cochlea build upon the underlying passive mechanics. Passive cochlear mechanics is based on physical and geometrical properties of the cochlea and the fluid-tissue interaction between the cochlear partition and the surrounding fluid. Although the fluid-tissue interaction between the basilar membrane and the fluid in scala tympani (ST) has been explored in both active and passive cochleae, there was no experimental data on the fluid-tissue interaction on the scala media (SM) side of the partition. To this aim, we measured sound-evoked intracochlear pressure in SM close to the partition using micropressure sensors. All the SM pressure data are from passive cochleae, likely because the SM cochleostomy led to loss of endocochlear potential. Thus, these experiments are studies of passive cochlear mechanics. SM pressure close to the tissue showed a pattern of peaks and notches, which could be explained as an interaction between fast and slow (i.e., traveling wave) pressure modes. In several animals SM and ST pressure were measured in the same cochlea. Similar to previous studies, ST-pressure was dominated by a slow, traveling wave mode at stimulus frequencies in the vicinity of the best frequency of the measurement location, and by a fast mode above best frequency. Antisymmetric pressure between SM and ST supported the classic single-partition cochlear models, or a dual-partition model with tight coupling between partitions. From the SM and ST pressure we calculated slow and fast modes, and from active ST pressure we extrapolated the passive findings to the active case. The passive slow mode estimated from SM and ST data was low-pass in nature, as predicted by cochlear models. Copyright © 2015 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Intracochlear Scala Media Pressure Measurement: Implications for Models of Cochlear Mechanics

PubMed Central

Kale, Sushrut S.; Olson, Elizabeth S.

2015-01-01

Models of the active cochlea build upon the underlying passive mechanics. Passive cochlear mechanics is based on physical and geometrical properties of the cochlea and the fluid-tissue interaction between the cochlear partition and the surrounding fluid. Although the fluid-tissue interaction between the basilar membrane and the fluid in scala tympani (ST) has been explored in both active and passive cochleae, there was no experimental data on the fluid-tissue interaction on the scala media (SM) side of the partition. To this aim, we measured sound-evoked intracochlear pressure in SM close to the partition using micropressure sensors. All the SM pressure data are from passive cochleae, likely because the SM cochleostomy led to loss of endocochlear potential. Thus, these experiments are studies of passive cochlear mechanics. SM pressure close to the tissue showed a pattern of peaks and notches, which could be explained as an interaction between fast and slow (i.e., traveling wave) pressure modes. In several animals SM and ST pressure were measured in the same cochlea. Similar to previous studies, ST-pressure was dominated by a slow, traveling wave mode at stimulus frequencies in the vicinity of the best frequency of the measurement location, and by a fast mode above best frequency. Antisymmetric pressure between SM and ST supported the classic single-partition cochlear models, or a dual-partition model with tight coupling between partitions. From the SM and ST pressure we calculated slow and fast modes, and from active ST pressure we extrapolated the passive findings to the active case. The passive slow mode estimated from SM and ST data was low-pass in nature, as predicted by cochlear models. PMID:26682824

Shear wave splitting and crustal anisotropy at the Mid-Atlantic Ridge, 35°N

NASA Astrophysics Data System (ADS)

Barclay, Andrew H.; Toomey, Douglas R.

2003-08-01

Shear wave splitting observed in microearthquake data at the axis of the Mid-Atlantic Ridge near 35°N has a fast polarization direction that is parallel to the trend of the axial valley. The time delays between fast and slow S wave arrivals range from 35 to 180 ms, with an average of 90 ms, and show no relationship with ray path length, source-to-receiver azimuth, or receiver location. The anisotropy is attributed to a shallow distribution of vertical, fluid-filled cracks, aligned parallel to the trend of the axial valley. Joint modeling of the shear wave anisotropy and coincident P wave anisotropy results, using recent theoretical models for the elasticity of a porous medium with aligned cracks, suggests that the crack distribution that causes the observed P wave anisotropy can account for at most 10 ms of the shear wave delay. Most of the shear wave delay thus likely accrues within the shallowmost 500 m (seismic layer 2A), and the percent S wave anisotropy within this highly fissured layer is 8-30%. Isolated, fluid-filled cracks at 500 m to 3 km depth that are too thin or too shallow to be detected by the P wave experiment may also contribute to the shear wave delays. The joint analysis of P and S wave anisotropy is an important approach for constraining the crack distributions in the upper oceanic crust and is especially suited for seismically active hydrothermal systems at slow and intermediate spreading mid-ocean ridges.

APPARENT CROSS-FIELD SUPERSLOW PROPAGATION OF MAGNETOHYDRODYNAMIC WAVES IN SOLAR PLASMAS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaneko, T.; Yokoyama, T.; Goossens, M.

2015-10-20

In this paper we show that the phase-mixing of continuum Alfvén waves and/or continuum slow waves in the magnetic structures of the solar atmosphere as, e.g., coronal arcades, can create the illusion of wave propagation across the magnetic field. This phenomenon could be erroneously interpreted as fast magnetosonic waves. The cross-field propagation due to the phase-mixing of continuum waves is apparent because there is no real propagation of energy across the magnetic surfaces. We investigate the continuous Alfvén and slow spectra in two-dimensional (2D) Cartesian equilibrium models with a purely poloidal magnetic field. We show that apparent superslow propagation acrossmore » the magnetic surfaces in solar coronal structures is a consequence of the existence of continuum Alfvén waves and continuum slow waves that naturally live on those structures and phase-mix as time evolves. The apparent cross-field phase velocity is related to the spatial variation of the local Alfvén/slow frequency across the magnetic surfaces and is slower than the Alfvén/sound velocities for typical coronal conditions. Understanding the nature of the apparent cross-field propagation is important for the correct analysis of numerical simulations and the correct interpretation of observations.« less

Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning

PubMed Central

Eschenko, Oxana; Ramadan, Wiâm; Mölle, Matthias; Born, Jan; Sara, Susan J.

2008-01-01

High-frequency oscillations, known as sharp-wave/ripple (SPW-R) complexes occurring in hippocampus during slow-wave sleep (SWS), have been proposed to promote synaptic plasticity necessary for memory consolidation. We recorded sleep for 3 h after rats were trained on an odor-reward association task. Learning resulted in an increased number SPW-Rs during the first hour of post-learning SWS. The magnitude of ripple events and their duration were also elevated for up to 2 h after the newly formed memory. Rats that did not learn the discrimination during the training session did not show any change in SPW-Rs. Successful retrieval from remote memory was likewise accompanied by an increase in SPW-R density and magnitude, relative to the previously recorded baseline, but the effects were much shorter lasting and did not include increases in ripple duration and amplitude. A short-lasting increase of ripple activity was also observed when rats were rewarded for performing a motor component of the task only. There were no increases in ripple activity after habituation to the experimental environment. These experiments show that the characteristics of hippocampal high-frequency oscillations during SWS are affected by prior behavioral experience. Associative learning induces robust and sustained (up to 2 h) changes in several SPW-R characteristics, while after retrieval from remote memory or performance of a well-trained procedural aspect of the task, only transient changes in ripple density were induced. PMID:18385477

Pulse propagation in discrete excitatory networks of integrate-and-fire neurons.

PubMed

Badel, Laurent; Tonnelier, Arnaud

2004-07-01

We study the propagation of solitary waves in a discrete excitatory network of integrate-and-fire neurons. We show the existence and the stability of a fast wave and a family of slow waves. Fast waves are similar to those already described in continuum networks. Stable slow waves have not been previously reported in purely excitatory networks and their propagation is particular to the discrete nature of the network. The robustness of our results is studied in the presence of noise.

Slow Wave Sleep and Long Duration Spaceflight

NASA Technical Reports Server (NTRS)

Whitmire, Alexandra; Orr, Martin; Arias, Diana; Rueger, Melanie; Johnston, Smith; Leveton, Lauren

2012-01-01

While ground research has clearly shown that preserving adequate quantities of sleep is essential for optimal health and performance, changes in the progression, order and /or duration of specific stages of sleep is also associated with deleterious outcomes. As seen in Figure 1, in healthy individuals, REM and Non-REM sleep alternate cyclically, with stages of Non-REM sleep structured chronologically. In the early parts of the night, for instance, Non-REM stages 3 and 4 (Slow Wave Sleep, or SWS) last longer while REM sleep spans shorter; as night progresses, the length of SWS is reduced as REM sleep lengthens. This process allows for SWS to establish precedence , with increases in SWS seen when recovering from sleep deprivation. SWS is indeed regarded as the most restorative portion of sleep. During SWS, physiological activities such as hormone secretion, muscle recovery, and immune responses are underway, while neurological processes required for long term learning and memory consolidation, also occur. The structure and duration of specific sleep stages may vary independent of total sleep duration, and changes in the structure and duration have been shown to be associated with deleterious outcomes. Individuals with narcolepsy enter sleep through REM as opposed to stage 1 of NREM. Disrupting slow wave sleep for several consecutive nights without reducing total sleep duration or sleep efficiency is associated with decreased pain threshold, increased discomfort, fatigue, and the inflammatory flare response in skin. Depression has been shown to be associated with a reduction of slow wave sleep and increased REM sleep. Given research that shows deleterious outcomes are associated with changes in sleep structure, it is essential to characterize and mitigate not only total sleep duration, but also changes in sleep stages.

Fast decomposition of two ultrasound longitudinal waves in cancellous bone using a phase rotation parameter for bone quality assessment: Simulation study.

PubMed

Taki, Hirofumi; Nagatani, Yoshiki; Matsukawa, Mami; Kanai, Hiroshi; Izumi, Shin-Ichi

2017-10-01

Ultrasound signals that pass through cancellous bone may be considered to consist of two longitudinal waves, which are called fast and slow waves. Accurate decomposition of these fast and slow waves is considered to be highly beneficial in determination of the characteristics of cancellous bone. In the present study, a fast decomposition method using a wave transfer function with a phase rotation parameter was applied to received signals that have passed through bovine bone specimens with various bone volume to total volume (BV/TV) ratios in a simulation study, where the elastic finite-difference time-domain method is used and the ultrasound wave propagated parallel to the bone axes. The proposed method succeeded to decompose both fast and slow waves accurately; the normalized residual intensity was less than -19.5 dB when the specimen thickness ranged from 4 to 7 mm and the BV/TV value ranged from 0.144 to 0.226. There was a strong relationship between the phase rotation value and the BV/TV value. The ratio of the peak envelope amplitude of the decomposed fast wave to that of the slow wave increased monotonically with increasing BV/TV ratio, indicating the high performance of the proposed method in estimation of the BV/TV value in cancellous bone.

Calcium waves.

PubMed

Jaffe, Lionel F

2008-04-12

Waves through living systems are best characterized by their speeds at 20 degrees C. These speeds vary from those of calcium action potentials to those of ultraslow ones which move at 1-10 and/or 10-20 nm s(-1). All such waves are known or inferred to be calcium waves. The two classes of calcium waves which include ones with important morphogenetic effects are slow waves that move at 0.2-2 microm s(-1) and ultraslow ones. Both may be propagated by cycles in which the entry of calcium through the plasma membrane induces subsurface contraction. This contraction opens nearby stretch-sensitive calcium channels. Calcium entry through these channels propagates the calcium wave. Many slow waves are seen as waves of indentation. Some are considered to act via cellular peristalsis; for example, those which seem to drive the germ plasm to the vegetal pole of the Xenopus egg. Other good examples of morphogenetic slow waves are ones through fertilizing maize eggs, through developing barnacle eggs and through axolotl embryos during neural induction. Good examples of ultraslow morphogenetic waves are ones during inversion in developing Volvox embryos and across developing Drosophila eye discs. Morphogenetic waves may be best pursued by imaging their calcium with aequorins.

Blindfolding during wakefulness causes decrease in sleep slow wave activity.

PubMed

Korf, Eva Magdalena; Mölle, Matthias; Born, Jan; Ngo, Hong-Viet V

2017-04-01

Slow wave activity (SWA, 0.5-4 Hz) represents the predominant EEG oscillatory activity during slow wave sleep (SWS). Its amplitude is considered in part a reflection of synaptic potentiation in cortical networks due to encoding of information during prior waking, with higher amplitude indicating stronger potentiation. Previous studies showed that increasing and diminishing specific motor behaviors produced corresponding changes in SWA in the respective motor cortical areas during subsequent SWS Here, we tested whether this relationship can be generalized to the visual system, that is, whether diminishing encoding of visual information likewise leads to a localized decrease in SWA over the visual cortex. Experiments were performed in healthy men whose eyes on two different days were or were not covered for 10.5 h before bedtime. The subject's EEG was recorded during sleep and, after sleep, visual evoked potentials (VEPs) were recorded. SWA during nonrapid eye movement sleep (NonREM sleep) was lower after blindfolding than after eyes open ( P  < 0.01). The decrease in SWA that was most consistent during the first 20 min of NonREM sleep, did not remain restricted to visual cortex regions, with changes over frontal and parietal cortical regions being even more pronounced. In the morning after sleep, the N75-P100 peak-to-peak-amplitude of the VEP was significantly diminished in the blindfolded condition. Our findings confirm a link between reduced wake encoding and diminished SWA during ensuing NonREM sleep, although this link appears not to be restricted to sensory cortical areas. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

Very low frequency earthquakes in Tohoku-Oki recorded by short-period ocean bottom seismographs

NASA Astrophysics Data System (ADS)

Takahashi, H.; Hino, R.; Ohta, Y.; Uchida, N.; Suzuki, S.; Shinohara, M.; Nakatani, Y.; Matsuzawa, T.

2017-12-01

Various kind of slow earthquakes have been found along many plate boundary zones in the world (Obara, and Kato, 2016). In the Tohoku subduction zone where slow event activities have been considered insignificant, slow slip events associated with low frequency tremors were identified prior to the 2011 Tohoku-Oki earthquake based on seafloor geodetic and seismographical observations. Recently very low frequency earthquakes (VLFEs) have been discovered by inspecting onshore broad-band seismograms. Although the activity of the detected VLFEs is low and the VLFEs occurred in the limited area, VLFEs tends to occur successively in a short time period. In this study, we try to characterize the VLFEs along the Japan Trench based on the seismograms obtained by the instruments deployed near the estimated epicenters.Temporary seismic observations using Ocean Bottom Seismometers (OBSs) have been carried out several times after the 2011 Tohoku-Oki earthquake, and several VLFE activities were observed during the deployments of the OBSs. Amplitudes of horizontal component seismograms of the OBSs grow shortly after the estimated origin times of the VLFEs identified by the onshore seismograms, even though the sensors are 4.5 Hz geophones. It is difficult to recognize evident onsets of P or S waves, correspondence between order of arrivals of discernible wave packets and their amplitudes suggests that these wave packets are seismic signals radiated from the VLFE sources. The OBSs detect regular local earthquakes of the similar magnitudes as the VLFEs. Signal powers of the possible VLFE seismograms are comparable to the regular earthquakes in the frequency range < 1 Hz, while significant deficiency of higher frequency components are observed.

Technologically sensed social exposure related to slow-wave sleep in healthy adults.

PubMed

Butt, Maryam; Ouarda, Taha B M J; Quan, Stuart F; Pentland, Alex Sandy; Khayal, Inas

2015-03-01

The aim of this study is to understand the relationship between automatically captured social exposure and detailed sleep parameters of healthy young adults. This study was conducted in a real-world setting in a graduate-student housing community at a US university. Social exposure was measured using Bluetooth proximity sensing technology in mobile devices. Sleep was monitored in a naturalistic setting using a headband sleep monitoring device over a period of 2 weeks. The analysis included a total of 11 subjects (6 males and 5 females) aged 24-35 (149 subject nights). Slow-wave sleep showed a significant positive correlation (Spearman's rho = 0.51, p < 0.0001) with social exposure, whereas light non-REM (N1 + N2) sleep and wake time were found to be negatively correlated (rho = -0.25, p < 0.01; rho = -0.21, p < 0.01, respectively). The correlation of median slow-wave sleep with median social exposure per subject showed a strong positive significance (rho = 0.88, p < 0.001). On average, within subjects, following day's social exposure was higher when (slow-wave NREM + REM) percentage was high (Wilcoxon sign-ranked test, p < 0.05). Subjects with higher social exposure spent more time in slow-wave sleep. Following day's social exposure was found to be positively affected by previous night's (slow-wave NREM + REM) percentage. This suggests that sleep affects following day's social exposure and not vice versa. Capturing an individual's dynamic social behavior and sleep from their natural environment can provide novel insights into these relationships.

Eye Movement Desensitization and Reprocessing and Slow Wave Sleep: A Putative Mechanism of Action.

PubMed

Pagani, Marco; Amann, Benedikt L; Landin-Romero, Ramon; Carletto, Sara

2017-01-01

Eye Movement Desensitization and Reprocessing (EMDR) is considered highly efficacious for the treatment of Post-traumatic Stress Disorder and has proved to be a valid treatment approach with a wide range of applications. However, EMDR's mechanisms of action is not yet fully understood. This is an active area of clinical and neurophysiological research, and several different hypotheses have been proposed. This paper discusses a conjecture which focuses on the similarity between the delta waves recorded by electroencephalography during Slow Wave Sleep (SWS) and those registered upon typical EMDR bilateral stimulation (eye movements or alternate tapping) during recurrent distressing memories of an emotionally traumatic event. SWS appears to have a key role in memory consolidation and in the reorganization of distant functional networks, as well as Eye Movements seem to reduce traumatic episodic memory and favor the reconsolidation of new associated information. The SWS hypothesis may put forward an explanation of how EMDR works, and is discussed also in light of other theories and neurobiological findings.

Eye Movement Desensitization and Reprocessing and Slow Wave Sleep: A Putative Mechanism of Action

PubMed Central

Pagani, Marco; Amann, Benedikt L.; Landin-Romero, Ramon; Carletto, Sara

2017-01-01

Eye Movement Desensitization and Reprocessing (EMDR) is considered highly efficacious for the treatment of Post-traumatic Stress Disorder and has proved to be a valid treatment approach with a wide range of applications. However, EMDR’s mechanisms of action is not yet fully understood. This is an active area of clinical and neurophysiological research, and several different hypotheses have been proposed. This paper discusses a conjecture which focuses on the similarity between the delta waves recorded by electroencephalography during Slow Wave Sleep (SWS) and those registered upon typical EMDR bilateral stimulation (eye movements or alternate tapping) during recurrent distressing memories of an emotionally traumatic event. SWS appears to have a key role in memory consolidation and in the reorganization of distant functional networks, as well as Eye Movements seem to reduce traumatic episodic memory and favor the reconsolidation of new associated information. The SWS hypothesis may put forward an explanation of how EMDR works, and is discussed also in light of other theories and neurobiological findings. PMID:29163309

Fast-slow asymptotic for semi-analytical ignition criteria in FitzHugh-Nagumo system.

PubMed

Bezekci, B; Biktashev, V N

2017-09-01

We study the problem of initiation of excitation waves in the FitzHugh-Nagumo model. Our approach follows earlier works and is based on the idea of approximating the boundary between basins of attraction of propagating waves and of the resting state as the stable manifold of a critical solution. Here, we obtain analytical expressions for the essential ingredients of the theory by singular perturbation using two small parameters, the separation of time scales of the activator and inhibitor and the threshold in the activator's kinetics. This results in a closed analytical expression for the strength-duration curve.

Dynamic Interaction of Spindles and Gamma Activity during Cortical Slow Oscillations and Its Modulation by Subcortical Afferents

PubMed Central

Valencia, Miguel; Artieda, Julio; Bolam, J. Paul; Mena-Segovia, Juan

2013-01-01

Slow oscillations are a hallmark of slow wave sleep. They provide a temporal framework for a variety of phasic events to occur and interact during sleep, including the expression of high-frequency oscillations and the discharge of neurons across the entire brain. Evidence shows that the emergence of distinct high-frequency oscillations during slow oscillations facilitates the communication among brain regions whose activity was correlated during the preceding waking period. While the frequencies of oscillations involved in such interactions have been identified, their dynamics and the correlations between them require further investigation. Here we analyzed the structure and dynamics of these signals in anesthetized rats. We show that spindles and gamma oscillations coexist but have distinct temporal dynamics across the slow oscillation cycle. Furthermore, we observed that spindles and gamma are functionally coupled to the slow oscillations and between each other. Following the activation of ascending pathways from the brainstem by means of a carbachol injection in the pedunculopontine nucleus, we were able to modify the gain in the gamma oscillations that are independent of the spindles while the spindle amplitude was reduced. Furthermore, carbachol produced a decoupling of the gamma oscillations that are dependent on the spindles but with no effect on their amplitude. None of the changes in the high-frequency oscillations affected the onset or shape of the slow oscillations, suggesting that slow oscillations occur independently of the phasic events that coexist with them. Our results provide novel insights into the regulation, dynamics and homeostasis of cortical slow oscillations. PMID:23844020

A search in strainmeter data for slow slip associated with triggered and ambient tremor near Parkfield, California

USGS Publications Warehouse

Smith, E.F.; Gomberg, J.

2009-01-01

We test the hypothesis that, as in subduction zones, slow slip facilitates triggered and ambient tremor in the transform boundary setting of California. Our study builds on the study of Peng et al. (2009) of triggered and ambient tremor near Parkfield, California during time intervals surrounding 31, potentially triggering, M ≥ 7.5 teleseismic earthquakes; waves from 10 of these triggered tremor and 29 occurred in periods of ambient tremor activity. We look for transient slow slip during 3-month windows that include 11 of these triggering and nontriggering teleseisms, using continuous strain data recorded on two borehole Gladwin tensor strainmeters (GTSM) located within the distribution of tremor epicenters. We model the GTSM data assuming only tidal and “drift” signals are present and find no detectable slow slip, either ongoing when the teleseismic waves passed or triggered by them. We infer a conservative detection threshold of about 5 nanostrain for abrupt changes and about twice this for slowly evolving signals. This could be lowered slightly by adding analyses of other data types, modeled slow slip signals, and GTSM data calibration. Detection of slow slip also depends on the slipping fault's location and size, which we describe in terms of equivalent earthquake moment magnitude, M. In the best case of the GTSM above a very shallow slipping fault, detectable slip events must exceed M~2, and if the slow slip is beneath the seismogenic zone (below ~15 km depth), even M~5 events are likely to remain hidden.

Costs of storing colour and complex shape in visual working memory: Insights from pupil size and slow waves.

PubMed

Kursawe, Michael A; Zimmer, Hubert D

2015-06-01

We investigated the impact of perceptual processing demands on visual working memory of coloured complex random polygons during change detection. Processing load was assessed by pupil size (Exp. 1) and additionally slow wave potentials (Exp. 2). Task difficulty was manipulated by presenting different set sizes (1, 2, 4 items) and by making different features (colour, shape, or both) task-relevant. Memory performance in the colour condition was better than in the shape and both condition which did not differ. Pupil dilation and the posterior N1 increased with set size independent of type of feature. In contrast, slow waves and a posterior P2 component showed set size effects but only if shape was task-relevant. In the colour condition slow waves did not vary with set size. We suggest that pupil size and N1 indicates different states of attentional effort corresponding to the number of presented items. In contrast, slow waves reflect processes related to encoding and maintenance strategies. The observation that their potentials vary with the type of feature (simple colour versus complex shape) indicates that perceptual complexity already influences encoding and storage and not only comparison of targets with memory entries at the moment of testing. Copyright © 2015 Elsevier B.V. All rights reserved.

Radial anisotropy of the North American upper mantle based on adjoint tomography with USArray

NASA Astrophysics Data System (ADS)

Zhu, Hejun; Komatitsch, Dimitri; Tromp, Jeroen

2017-10-01

We use seismic data from USArray to image the upper mantle underneath the United States based on a so-called `adjoint tomography', an iterative full waveform inversion technique. The inversion uses data from 180 regional earthquakes recorded by 4516 seismographic stations, resulting in 586 185 frequency-dependent measurements. Three-component short-period body waves and long-period surface waves are combined to simultaneously constrain deep and shallow structures. The transversely isotropic model US22 is the result of 22 pre-conditioned conjugate-gradient iterations. Approximate Hessian maps and point-spread function tests demonstrate good illumination of the study region and limited trade-offs among different model parameters. We observe a distinct wave-speed contrast between the stable eastern US and the tectonically active western US. This boundary is well correlated with the Rocky Mountain Front. Stable cratonic regions are characterized by fast anomalies down to 250-300 km, reflecting the thickness of the North American lithosphere. Several fast anomalies are observed beneath the North American lithosphere, suggesting the possibility of lithospheric delamination. Slow wave-speed channels are imaged beneath the lithosphere, which might indicate weak asthenosphere. Beneath the mantle transition zone of the central US, an elongated north-south fast anomaly is observed, which might be the ancient subducted Farallon slab. The tectonically active western US is dominated by prominent slow anomalies with magnitudes greater than -6 per cent down to approximately 250 km. No continuous lower to upper mantle upwellings are observed beneath Yellowstone. In addition, our results confirm previously observed differences between oceans and continents in the anisotropic parameter ξ = (βh/βv)2. A slow wave-speed channel with ξ > 1 is imaged beneath the eastern Pacific at depths from 100 to 200 km, reflecting horizontal shear within the asthenosphere. Underneath continental areas, regions with ξ > 1 are imaged at shallower depths around 100 km. They are characterized by fast shear wave speeds, suggesting different origins of anisotropy underneath oceans and continents. The wave speed and anisotropic signatures of the western Atlantic are similar to continental areas in comparison with the eastern Pacific. Furthermore, we observe regions with ξ < 1 beneath the tectonically active western US at depths between 300 and 400 km, which might reflect vertical flows induced by subduction of the Farallon and Juan de Fuca Plates. Comparing US22 with several previous tomographic models, we observe relatively good correlations for long-wavelength features. However, there are still large discrepancies for small-scale features.

The Nucleus Reuniens Controls Long-Range Hippocampo-Prefrontal Gamma Synchronization during Slow Oscillations.

PubMed

Ferraris, Maëva; Ghestem, Antoine; Vicente, Ana F; Nallet-Khosrofian, Lauriane; Bernard, Christophe; Quilichini, Pascale P

2018-03-21

Gamma oscillations are involved in long-range coupling of distant regions that support various cognitive operations. Here we show in adult male rats that synchronized bursts of gamma oscillations bind the hippocampus (HPC) and prefrontal cortex (mPFC) during slow oscillations and slow-wave sleep, a brain state that is central for consolidation of memory traces. These gamma bursts entrained the firing of the local HPC and mPFC neuronal populations. Neurons of the nucleus reuniens (NR), which is a structural and functional hub between HPC and mPFC, demonstrated a specific increase in their firing before gamma burst onset, suggesting their involvement in HPC-mPFC binding. Chemical inactivation of NR disrupted the temporal pattern of gamma bursts and their synchronization, as well as mPFC neuronal firing. We propose that the NR drives long-range hippocampo-prefrontal coupling via gamma bursts providing temporal windows for information exchange between the HPC and mPFC during slow-wave sleep. SIGNIFICANCE STATEMENT Long-range coupling between hippocampus (HPC) and prefrontal cortex (mPFC) is believed to support numerous cognitive functions, including memory consolidation occurring during sleep. Gamma-band synchronization is a fundamental process in many neuronal operations and is instrumental in long-range coupling. Recent evidence highlights the role of nucleus reuniens (NR) in consolidation; however, how it influences hippocampo-prefrontal coupling is unknown. In this study, we show that HPC and mPFC are synchronized by gamma bursts during slow oscillations in anesthesia and natural sleep. By manipulating and recording the NR-HPC-mPFC network, we provide evidence that the NR actively promotes this long-range gamma coupling. This coupling provides the hippocampo-prefrontal circuit with a novel mechanism to exchange information during slow-wave sleep. Copyright © 2018 the authors 0270-6474/18/383026-13$15.00/0.

Synchronized gastric electrical stimulation improves vagotomy-induced impairment in gastric accommodation via the nitrergic pathway in dogs

PubMed Central

Chen, Jie; Koothan, Thillai; Chen, Jiande D. Z.

2009-01-01

Impaired gastric accommodation and gastric dysrhythmia are common in gastroparesis and functional dyspepsia. Recent studies have shown that synchronized gastric electrical stimulation (SGES) accelerates gastric emptying and enhances antral contractions in dogs. The aim of this study was to investigate the effects and mechanism of SGES on gastric accommodation and slow waves impaired by vagotomy in dogs. Gastric tone, compliance, and accommodation as well as slow waves with and without SGES were assessed in seven female regular dogs and seven dogs with bilateral truncal vagotomy, chronically implanted with gastric serosal electrodes and a gastric cannula. We found that 1) vagotomy impaired gastric accommodation that was normalized by SGES. The postprandial increase in gastric volume was 283.5 ± 50.6 ml in the controlled dogs, 155.2 ± 49.2 ml in the vagotomized dogs, and 304.0 ± 57.8 ml in the vagotomized dogs with SGES. The ameliorating effect of SGES was no longer observed after application of Nω-nitro-l-arginine (l-NNA); 2) vagotomy did not alter gastric compliance whereas SGES improved gastric compliance in the vagotomized dogs, and the improvement was also blocked by l-NNA; and 3) vagotomy impaired antral slow wave rhythmicity in both fasting and fed states. SGES at the proximal stomach enhanced the postprandial rhythmicity and amplitude (dominant power) of the gastric slow waves in the antrum. In conclusion, SGES with appropriate parameters restores gastric accommodation and improves gastric slow waves impaired by vagotomy. The improvement in gastric accommodation with SGES is mediated via the nitrergic pathway. Combined with previously reported findings (enhanced antral contractions and accelerated gastric emptying) and findings in this study (improved gastric accommodation and slow waves), SGES may be a viable therapy for gastroparesis. PMID:19023028

Single-subject-based whole-brain MEG slow-wave imaging approach for detecting abnormality in patients with mild traumatic brain injury

PubMed Central

Huang, Ming-Xiong; Nichols, Sharon; Baker, Dewleen G.; Robb, Ashley; Angeles, Annemarie; Yurgil, Kate A.; Drake, Angela; Levy, Michael; Song, Tao; McLay, Robert; Theilmann, Rebecca J.; Diwakar, Mithun; Risbrough, Victoria B.; Ji, Zhengwei; Huang, Charles W.; Chang, Douglas G.; Harrington, Deborah L.; Muzzatti, Laura; Canive, Jose M.; Christopher Edgar, J.; Chen, Yu-Han; Lee, Roland R.

2014-01-01

Traumatic brain injury (TBI) is a leading cause of sustained impairment in military and civilian populations. However, mild TBI (mTBI) can be difficult to detect using conventional MRI or CT. Injured brain tissues in mTBI patients generate abnormal slow-waves (1–4 Hz) that can be measured and localized by resting-state magnetoencephalography (MEG). In this study, we develop a voxel-based whole-brain MEG slow-wave imaging approach for detecting abnormality in patients with mTBI on a single-subject basis. A normative database of resting-state MEG source magnitude images (1–4 Hz) from 79 healthy control subjects was established for all brain voxels. The high-resolution MEG source magnitude images were obtained by our recent Fast-VESTAL method. In 84 mTBI patients with persistent post-concussive symptoms (36 from blasts, and 48 from non-blast causes), our method detected abnormalities at the positive detection rates of 84.5%, 86.1%, and 83.3% for the combined (blast-induced plus with non-blast causes), blast, and non-blast mTBI groups, respectively. We found that prefrontal, posterior parietal, inferior temporal, hippocampus, and cerebella areas were particularly vulnerable to head trauma. The result also showed that MEG slow-wave generation in prefrontal areas positively correlated with personality change, trouble concentrating, affective lability, and depression symptoms. Discussion is provided regarding the neuronal mechanisms of MEG slow-wave generation due to deafferentation caused by axonal injury and/or blockages/limitations of cholinergic transmission in TBI. This study provides an effective way for using MEG slow-wave source imaging to localize affected areas and supports MEG as a tool for assisting the diagnosis of mTBI. PMID:25009772

Propagating Neural Source Revealed by Doppler Shift of Population Spiking Frequency

PubMed Central

Zhang, Mingming; Shivacharan, Rajat S.; Chiang, Chia-Chu; Gonzalez-Reyes, Luis E.

2016-01-01

Electrical activity in the brain during normal and abnormal function is associated with propagating waves of various speeds and directions. It is unclear how both fast and slow traveling waves with sometime opposite directions can coexist in the same neural tissue. By recording population spikes simultaneously throughout the unfolded rodent hippocampus with a penetrating microelectrode array, we have shown that fast and slow waves are causally related, so a slowly moving neural source generates fast-propagating waves at ∼0.12 m/s. The source of the fast population spikes is limited in space and moving at ∼0.016 m/s based on both direct and Doppler measurements among 36 different spiking trains among eight different hippocampi. The fact that the source is itself moving can account for the surprising direction reversal of the wave. Therefore, these results indicate that a small neural focus can move and that this phenomenon could explain the apparent wave reflection at tissue edges or multiple foci observed at different locations in neural tissue. SIGNIFICANCE STATEMENT The use of novel techniques with an unfolded hippocampus and penetrating microelectrode array to record and analyze neural activity has revealed the existence of a source of neural signals that propagates throughout the hippocampus. The source itself is electrically silent, but its location can be inferred by building isochrone maps of population spikes that the source generates. The movement of the source can also be tracked by observing the Doppler frequency shift of these spikes. These results have general implications for how neural signals are generated and propagated in the hippocampus; moreover, they have important implications for the understanding of seizure generation and foci localization. PMID:27013678

Collisionless slow shocks in magnetotail reconnection

NASA Astrophysics Data System (ADS)

Cremer, Michael; Scholer, Manfred

The kinetic structure of collisionless slow shocks in the magnetotail is studied by solving the Riemann problem of the collapse of a current sheet with a normal magnetic field component using 2-D hybrid simulations. The collapse results in a current layer with a hot isotropic distribution and backstreaming ions in a boundary layer. The lobe plasma outside and within the boundary layer exhibits a large perpendicular to parallel temperature anisotropy. Waves in both regions propagate parallel to the magnetic field. In a second experiment a spatially limited high density beam is injected into a low beta background plasma and the subsequent wave excitation is studied. A model for slow shocks bounding the reconnection layer in the magnetotail is proposed where backstreaming ions first excite obliquely propagating waves by the electromagnetic ion/ion cyclotron instability, which lead to perpendicular heating. The T⊥/T∥ temperature anisotropy subsequently excites parallel propagating Alfvén ion cyclotron waves, which are convected into the slow shock and are refracted in the downstream region.

Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting.

PubMed

Helfrich, Randolph F; Mander, Bryce A; Jagust, William J; Knight, Robert T; Walker, Matthew P

2018-01-03

The coupled interaction between slow-wave oscillations and sleep spindles during non-rapid-eye-movement (NREM) sleep has been proposed to support memory consolidation. However, little evidence in humans supports this theory. Moreover, whether such dynamic coupling is impaired as a consequence of brain aging in later life, contributing to cognitive and memory decline, is unknown. Combining electroencephalography (EEG), structural MRI, and sleep-dependent memory assessment, we addressed these questions in cognitively normal young and older adults. Directional cross-frequency coupling analyses demonstrated that the slow wave governs a precise temporal coordination of sleep spindles, the quality of which predicts overnight memory retention. Moreover, selective atrophy within the medial frontal cortex in older adults predicted a temporal dispersion of this slow wave-spindle coupling, impairing overnight memory consolidation and leading to forgetting. Prefrontal-dependent deficits in the spatiotemporal coordination of NREM sleep oscillations therefore represent one pathway explaining age-related memory decline. Copyright © 2017 Elsevier Inc. All rights reserved.

P-wave velocity structure of the uppermost mantle beneath Hawaii from traveltime tomography

USGS Publications Warehouse

Tilmann, F.J.; Benz, H.M.; Priestley, K.F.; Okubo, P.G.

2001-01-01

We examine the P-wave velocity structure beneath the island of Hawaii using P-wave residuals from teleseismic earthquakes recorded by the Hawaiian Volcano Observatory seismic network. The station geometry and distribution of events makes it possible to image the velocity structure between ~ 40 and 100 km depth with a lateral resolution of ~ 15 km and a vertical resolution of ~ 30 km. For depths between 40 and 80 km, P-wave velocities are up to 5 per cent slower in a broad elongated region trending SE-NW that underlies the island between the two lines defined by the volcanic loci. No direct correlation between the magnitude of the lithospheric anomaly and the current level of volcanic activity is apparent, but the slow region is broadened at ~ 19.8??N and narrow beneath Kilauea. In the case of the occanic lithosphere beneath Hawaii, slow seismic velocities are likely to be related to magma transport from the top of the melting zone at the base of the lithosphere to the surface. Thermal modelling shows that the broad elongated low-velocity zone cannot be explained in terms of conductive heating by one primary conduit per volcano but that more complicated melt pathways must exist.

Emergence of Slow Collective Oscillations in Neural Networks with Spike-Timing Dependent Plasticity

NASA Astrophysics Data System (ADS)

Mikkelsen, Kaare; Imparato, Alberto; Torcini, Alessandro

2013-05-01

The collective dynamics of excitatory pulse coupled neurons with spike-timing dependent plasticity is studied. The introduction of spike-timing dependent plasticity induces persistent irregular oscillations between strongly and weakly synchronized states, reminiscent of brain activity during slow-wave sleep. We explain the oscillations by a mechanism, the Sisyphus Effect, caused by a continuous feedback between the synaptic adjustments and the coherence in the neural firing. Due to this effect, the synaptic weights have oscillating equilibrium values, and this prevents the system from relaxing into a stationary macroscopic state.

Lennox-Gastaut Syndrome: Potential Mechanisms of Cognitive Regression

ERIC Educational Resources Information Center

Blume, Warren T.

2004-01-01

Lennox-Gastaut (L-G) syndrome is an intractable generalized epilepsy of childhood onset, associated with spike waves at a slow rate and paroxysmal fast activity. These epileptiform discharge patterns are thought to reflect excessive neocortical excitability and arise from neuronal and synaptic features peculiar to the immature central nervous…

Precursory changes in seismic velocity for the spectrum of earthquake failure modes

PubMed Central

Scuderi, M.M.; Marone, C.; Tinti, E.; Di Stefano, G.; Collettini, C.

2016-01-01

Temporal changes in seismic velocity during the earthquake cycle have the potential to illuminate physical processes associated with fault weakening and connections between the range of fault slip behaviors including slow earthquakes, tremor and low frequency earthquakes1. Laboratory and theoretical studies predict changes in seismic velocity prior to earthquake failure2, however tectonic faults fail in a spectrum of modes and little is known about precursors for those modes3. Here we show that precursory changes of wave speed occur in laboratory faults for the complete spectrum of failure modes observed for tectonic faults. We systematically altered the stiffness of the loading system to reproduce the transition from slow to fast stick-slip and monitored ultrasonic wave speed during frictional sliding. We find systematic variations of elastic properties during the seismic cycle for both slow and fast earthquakes indicating similar physical mechanisms during rupture nucleation. Our data show that accelerated fault creep causes reduction of seismic velocity and elastic moduli during the preparatory phase preceding failure, which suggests that real time monitoring of active faults may be a means to detect earthquake precursors. PMID:27597879

Electrostatic waves driven by electron beam in lunar wake plasma

NASA Astrophysics Data System (ADS)

Sreeraj, T.; Singh, S. V.; Lakhina, G. S.

2018-05-01

A linear analysis of electrostatic waves propagating parallel to the ambient field in a four component homogeneous, collisionless, magnetised plasma comprising fluid protons, fluid He++, electron beam, and suprathermal electrons following kappa distribution is presented. In the absence of electron beam streaming, numerical analysis of the dispersion relation shows six modes: two electron acoustic modes (modes 1 and 6), two fast ion acoustic modes (modes 2 and 5), and two slow ion acoustic modes (modes 3 and 4). The modes 1, 2 and 3 and modes 4, 5, and 6 have positive and negative phase speeds, respectively. With an increase in electron beam speed, the mode 6 gets affected the most and the phase speed turns positive from negative. The mode 6 thus starts to merge with modes 2 and 3 and generates the electron beam driven fast and slow ion acoustic waves unstable with a finite growth. The electron beam driven slow ion-acoustic waves occur at lower wavenumbers, whereas fast ion-acoustic waves occur at a large value of wavenumbers. The effect of various other parameters has also been studied. We have applied this analysis to the electrostatic waves observed in lunar wake during the first flyby of the ARTEMIS mission. The analysis shows that the low (high) frequency waves observed in the lunar wake could be the electron beam driven slow (fast) ion-acoustic modes.

Chaos and ion heating in a slow shock

NASA Technical Reports Server (NTRS)

Lin, Y.; Lee, L. C.

1991-01-01

An ion heating mechanism is proposed of slow shocks, which is associated with the chaotic motion of particles in the downstream wave field. For a coherent electromagnetic wave propagating along the downstream magnetic field, corresponding to switch-off shocks, the particle motions are not chaotic. For an oblique wave, the interaction between the particles and the wave field may lead to chaotic particle motions. Such particles may be greatly thermalized within one wavelength after they are incident into the downstream wave field. The results can be used to explain the existence of the critical intermediate Mach number observed in the hybrid simulations.

Coupled Transmission Line Based Slow Wave Structures for Traveling Wave Tubes Applications

NASA Astrophysics Data System (ADS)

Zuboraj, Md. Rashedul Alam

High power microwave devices especially Traveling Wave Tubes (TWTs) and Backward Wave Oscillators (BWOs) are largely dependent on Slow Wave Structures for efficient beam to RF coupling. In this work, a novel approach of analyzing SWSs is proposed and investigated. Specifically, a rigorous study of helical geometries is carried out and a novel SWS "Half-Ring-Helix" is designed. This Half-Ring-Helix circuit achieves 27% miniaturization and delivers 10dB more gain than conventional helices. A generalization of the helix structures is also proposed in the form of Coupled Transmission Line (CTL). It is demonstrated that control of coupling among the CTLs leads to new propagation properties. With this in mind, a novel geometry referred to as "Curved Ring-Bar" is introduced. This geometry is shown to deliver 1MW power across a 33% bandwidth. Notably, this is the first demonstration of MW power TWT across large bandwidth. The CTL is further expanded to enable engineered propagation characteristics. This is done by introducing CTLs having non-identical transmission lines and CTLs with as many as four transmission lines in the same slow wave structure circuit. These non-identical CTLs are demonstrated to generate fourth order dispersion curves. Building on the property of CTLs, a `butterfly' slow wave structure is developed and demonstrated to provide degenerate band edge (DBE) mode. This mode are known to provide large feld enhancement that can be exploited to design high power backward wave oscillators.

Enhanced traveling wave amplification of co-planar slow wave structure by extended phase-matching

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palm, Andrew; Sirigiri, Jagadishwar; Shin, Young-Min, E-mail: yshin@niu.edu

2015-09-15

The electron beam co-propagating with slow waves in a staggered double grating array (SDGA) efficiently amplifies millimeter and sub-millimeter waves over a wide spectrum. Our theoretical and numerical analyses show that the power amplification in the fundamental passband is enhanced by the extended beam-wave phase-matching. Particle-in-cell simulations on the SDGA slow wave structure, designed with 10.4 keV and 50–100 mA sheet beam, indicate that maintaining beam-wave synchronization along the entire length of the circuit improves the gain by 7.3% leading to a total gain of 28 dB, corresponding to 62 W saturated power at the middle of operating band, and a 3-dB bandwidthmore » of 7 GHz with 10.5% at V-band (73.5 GHz center frequency) with saturated peak power reaching 80 W and 28 dB at 71 GHz. These results also show a reasonably good agreement with analytic calculations based on Pierce small signal gain theory.« less

Plasma wave excitation by intense microwave transmission from a space vehicle

NASA Astrophysics Data System (ADS)

Kimura, I.; Matsumoto, H.; Kaya, N.; Miyatake, S.

An impact of intense microwave upon the ionospheric plasma was empirically investigated by an active rocket experiment (MINIX). The rocket carried two high-power (830W) transmitters of 2.45 GHz microwave on the mother section of the rocket. The ionospheric plasma response to the intense microwave was measured by a diagnostic package installed on both mother and daughter sections. The daughter section was separated from the mother with a slow speed of 15 cm/sec. The plasma wave analyzers revealed that various plasma waves are nonlinearly excited by the microwave. Among them, the most intense are electron cyclotron waves, followed by electron plasma waves. Extremely low frequency waves (several tens of Hz) are also found. The results of the data analysis as well as comparative computer simulations are given in this paper.

Napping to renew learning capacity: enhanced encoding after stimulation of sleep slow oscillations.

PubMed

Antonenko, Daria; Diekelmann, Susanne; Olsen, Cathrin; Born, Jan; Mölle, Matthias

2013-04-01

As well as consolidating memory, sleep has been proposed to serve a second important function for memory, i.e. to free capacities for the learning of new information during succeeding wakefulness. The slow wave activity (SWA) that is a hallmark of slow wave sleep could be involved in both functions. Here, we aimed to demonstrate a causative role for SWA in enhancing the capacity for encoding of information during subsequent wakefulness, using transcranial slow oscillation stimulation (tSOS) oscillating at 0.75 Hz to induce SWA in healthy humans during an afternoon nap. Encoding following the nap was tested for hippocampus-dependent declarative materials (pictures, word pairs, and word lists) and procedural skills (finger sequence tapping). As compared with a sham stimulation control condition, tSOS during the nap enhanced SWA and significantly improved subsequent encoding on all three declarative tasks (picture recognition, cued recall of word pairs, and free recall of word lists), whereas procedural finger sequence tapping skill was not affected. Our results indicate that sleep SWA enhances the capacity for encoding of declarative materials, possibly by down-scaling hippocampal synaptic networks that were potentiated towards saturation during the preceding period of wakefulness. © 2013 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder.

PubMed

Nishida, Masaki; Nakashima, Yusaku; Nishikawa, Toru

2016-01-01

Evidence has accumulated, which indicates that, in healthy individuals, sleep enhances procedural memory consolidation, and that sleep spindle activity modulates this process. However, whether sleep-dependent procedural memory consolidation occurs in patients medicated for major depressive disorder remains unclear, as are the pharmacological and physiological mechanisms that underlie this process. Healthy control participants (n=17) and patients medicated for major depressive disorder (n=11) were recruited and subjected to a finger-tapping motor sequence test (MST; nondominant hand) paradigm to compare the averaged scores of different learning phases (presleep, postsleep, and overnight improvement). Participants' brain activity was recorded during sleep with 16 electroencephalography channels (between MSTs). Sleep scoring and frequency analyses were performed on the electroencephalography data. Additionally, we evaluated sleep spindle activity, which divided the spindles into fast-frequency spindle activity (12.5-16 Hz) and slow-frequency spindle activity (10.5-12.5 Hz). Sleep-dependent motor memory consolidation in patients with depression was impaired in comparison with that in control participants. In patients with depression, age correlated negatively with overnight improvement. The duration of slow-wave sleep correlated with the magnitude of motor memory consolidation in patients with depression, but not in healthy controls. Slow-frequency spindle activity was associated with reduction in the magnitude of motor memory consolidation in both groups. Because the changes in slow-frequency spindle activity affected the thalamocortical network dysfunction in patients medicated for depression, dysregulated spindle generation may impair sleep-dependent memory consolidation. Our findings may help to elucidate the cognitive deficits that occur in patients with major depression both in the waking state and during sleep.

Slow waves in microchannel metal waveguides and application to particle acceleration

NASA Astrophysics Data System (ADS)

Steinhauer, L. C.; Kimura, W. D.

2003-06-01

Conventional metal-wall waveguides support waveguide modes with phase velocities exceeding the speed of light. However, for infrared frequencies and guide dimensions of a fraction of a millimeter, one of the waveguide modes can have a phase velocity equal to or less than the speed of light. Such a metal microchannel then acts as a slow-wave structure. Furthermore, if it is a transverse magnetic mode, the electric field has a component along the direction of propagation. Therefore, a strong exchange of energy can occur between a beam of charged particles and this slow-waveguide mode. Moreover, the energy exchange can be sustained over a distance limited only by the natural damping of the wave. This makes the microchannel metal waveguide an attractive possibility for high-gradient electron laser acceleration because the wave can be directly energized by a long-wavelength laser. Indeed the frequency of CO2 lasers lies at a fortuitous wavelength that produces a strong laser-particle interaction in a channel of reasonable macroscopic size (e.g., ˜0.6 mm). The dispersion properties including phase velocity and damping for the slow wave are developed. The performance and other issues related to laser accelerator applications are discussed.

Rotating magnetic shallow water waves and instabilities in a sphere

NASA Astrophysics Data System (ADS)

Márquez-Artavia, X.; Jones, C. A.; Tobias, S. M.

2017-07-01

Waves in a thin layer on a rotating sphere are studied. The effect of a toroidal magnetic field is considered, using the shallow water ideal MHD equations. The work is motivated by suggestions that there is a stably stratified layer below the Earth's core mantle boundary, and the existence of stable layers in stellar tachoclines. With an azimuthal background field known as the Malkus field, ?, ? being the co-latitude, a non-diffusive instability is found with azimuthal wavenumber ?. A necessary condition for instability is that the Alfvén speed exceeds ? where ? is the rotation rate and ? the sphere radius. Magneto-inertial gravity waves propagating westward and eastward occur, and become equatorially trapped when the field is strong. Magneto-Kelvin waves propagate eastward at low field strength, but a new westward propagating Kelvin wave is found when the field is strong. Fast magnetic Rossby waves travel westward, whilst the slow magnetic Rossby waves generally travel eastward, except for some ? modes at large field strength. An exceptional very slow westward ? magnetic Rossby wave mode occurs at all field strengths. The current-driven instability occurs for ? when the slow and fast magnetic Rossby waves interact. With strong field the magnetic Rossby waves become trapped at the pole. An asymptotic analysis giving the wave speed and wave form in terms of elementary functions is possible both in polar trapped and equatorially trapped cases.

Long-range correlation of the membrane potential in neocortical neurons during slow oscillation

PubMed Central

Volgushev, Maxim; Chauvette, Sylvain; Timofeev, Igor

2012-01-01

Large amplitude slow waves are characteristic for the summary brain activity, recorded as electroencephalogram (EEG) or local field potentials (LFP), during deep stages of sleep and some types of anesthesia. Slow rhythm of the synchronized EEG reflects an alternation of active (depolarized, UP) and silent (hyperpolarized, DOWN) states of neocortical neurons. In neurons, involvement in the generalized slow oscillation results in a long-range synchronization of changes of their membrane potential as well as their firing. Here, we aimed at intracellular analysis of details of this synchronization. We asked which components of neuronal activity exhibit long-range correlations during the synchronized EEG? To answer this question, we made simultaneous intracellular recordings from two to four neocortical neurons in cat neocortex. We studied how correlated is the occurrence of active and silent states, and how correlated are fluctuations of the membrane potential in pairs of neurons located close one to the other or separated by up to 13 mm. We show that strong long-range correlation of the membrane potential was observed only (i) during the slow oscillation but not during periods without the oscillation, (ii) during periods which included transitions between the states but not during within-the-state periods, and (iii) for the low-frequency (<5 Hz) components of membrane potential fluctuations but not for the higher-frequency components (>10 Hz). In contrast to the neurons located several millimeters one from the other, membrane potential fluctuations in neighboring neurons remain strongly correlated during periods without slow oscillation. We conclude that membrane potential correlation in distant neurons is brought about by synchronous transitions between the states, while activity within the states is largely uncorrelated. The lack of the generalized fine-scale synchronization of membrane potential changes in neurons during the active states of slow oscillation may allow individual neurons to selectively engage in short living episodes of correlated activity—a process that may be similar to dynamical formation of neuronal ensembles during activated brain states. PMID:21854963

Neuronal Networks in Children with Continuous Spikes and Waves during Slow Sleep

ERIC Educational Resources Information Center

Siniatchkin, Michael; Groening, Kristina; Moehring, Jan; Moeller, Friederike; Boor, Rainer; Brodbeck, Verena; Michel, Christoph M.; Rodionov, Roman; Lemieux, Louis; Stephani, Ulrich

2010-01-01

Epileptic encephalopathy with continuous spikes and waves during slow sleep is an age-related disorder characterized by the presence of interictal epileptiform discharges during at least greater than 85% of sleep and cognitive deficits associated with this electroencephalography pattern. The pathophysiological mechanisms of continuous spikes and…

3D Modeling of Antenna Driven Slow Waves Excited by Antennas Near the Plasma Edge

NASA Astrophysics Data System (ADS)

Smithe, David; Jenkins, Thomas

2016-10-01

Prior work with the 3D finite-difference time-domain (FDTD) plasma and sheath model used to model ICRF antennas in fusion plasmas has highlighted the possibility of slow wave excitation at the very low end of the SOL density range, and thus the prudent need for a slow-time evolution model to treat SOL density modifications due to the RF itself. At higher frequency, the DIII-D helicon antenna has much easier access to a parasitic slow wave excitation, and in this case the Faraday screen provides the dominant means of controlling the content of the launched mode, with antenna end-effects remaining a concern. In both cases, the danger is the same, with the slow-wave propagating into a lower-hybrid resonance layer a short distance ( cm) away from the antenna, which would parasitically absorb power, transferring energy to the SOL edge plasma, primarily through electron-neutral collisions. We will present 3D modeling of antennas at both ICRF and helicon frequencies. We've added a slow-time evolution capability for the SOL plasma density to include ponderomotive force driven rarefaction from the strong fields in the vicinity of the antenna, and show initial application to NSTX antenna geometry and plasma configurations. The model is based on a Scalar Ponderomotive Potential method, using self-consistently computed local field amplitudes from the 3D simulation.

Fast and Slow Spindles during the Sleep Slow Oscillation: Disparate Coalescence and Engagement in Memory Processing

PubMed Central

Mölle, Matthias; Bergmann, Til O.; Marshall, Lisa; Born, Jan

2011-01-01

Study Objectives: Thalamo-cortical spindles driven by the up-state of neocortical slow (< 1 Hz) oscillations (SOs) represent a candidate mechanism of memory consolidation during sleep. We examined interactions between SOs and spindles in human slow wave sleep, focusing on the presumed existence of 2 kinds of spindles, i.e., slow frontocortical and fast centro-parietal spindles. Design: Two experiments were performed in healthy humans (24.5 ± 0.9 y) investigating undisturbed sleep (Experiment I) and the effects of prior learning (word paired associates) vs. non-learning (Experiment II) on multichannel EEG recordings during sleep. Measurements and Results: Only fast spindles (12-15 Hz) were synchronized to the depolarizing SO up-state. Slow spindles (9-12 Hz) occurred preferentially at the transition into the SO down-state, i.e., during waning depolarization. Slow spindles also revealed a higher probability to follow rather than precede fast spindles. For sequences of individual SOs, fast spindle activity was largest for “initial” SOs, whereas SO amplitude and slow spindle activity were largest for succeeding SOs. Prior learning enhanced this pattern. Conclusions: The finding that fast and slow spindles occur at different times of the SO cycle points to disparate generating mechanisms for the 2 kinds of spindles. The reported temporal relationships during SO sequences suggest that fast spindles, driven by the SO up-state feed back to enhance the likelihood of succeeding SOs together with slow spindles. By enforcing such SO-spindle cycles, particularly after prior learning, fast spindles possibly play a key role in sleep-dependent memory processing. Citation: Mölle M; Bergmann TO; Marshall L; Born J. Fast and slow spindles during the sleep slow oscillation: disparate coalescence and engagement in memory processing. SLEEP 2011;34(10):1411–1421. PMID:21966073

The 2012 Mw5.6 earthquake in Sofia seismogenic zone - is it a slow earthquake

NASA Astrophysics Data System (ADS)

Raykova, Plamena; Solakov, Dimcho; Slavcheva, Krasimira; Simeonova, Stela; Aleksandrova, Irena

2017-04-01

Recently our understanding of tectonic faulting has been shaken by the discoveries of seismic tremor, low frequency earthquakes, slow slip events, and other models of fault slip. These phenomenas represent models of failure that were thought to be non-existent and theoretically impossible only a few years ago. Slow earthquakes are seismic phenomena in which the rupture of geological faults in the earth's crust occurs gradually without creating strong tremors. Despite the growing number of observations of slow earthquakes their origin remains unresolved. Studies show that the duration of slow earthquakes ranges from a few seconds to a few hundred seconds. The regular earthquakes with which most people are familiar release a burst of built-up stress in seconds, slow earthquakes release energy in ways that do little damage. This study focus on the characteristics of the Mw5.6 earthquake occurred in Sofia seismic zone on May 22nd, 2012. The Sofia area is the most populated, industrial and cultural region of Bulgaria that faces considerable earthquake risk. The Sofia seismic zone is located in South-western Bulgaria - the area with pronounce tectonic activity and proved crustal movement. In 19th century the city of Sofia (situated in the centre of the Sofia seismic zone) has experienced two strong earthquakes with epicentral intensity of 10 MSK. During the 20th century the strongest event occurred in the vicinity of the city of Sofia is the 1917 earthquake with MS=5.3 (I0=7-8 MSK64).The 2012 quake occurs in an area characterized by a long quiescence (of 95 years) for moderate events. Moreover, a reduced number of small earthquakes have also been registered in the recent past. The Mw5.6 earthquake is largely felt on the territory of Bulgaria and neighbouring countries. No casualties and severe injuries have been reported. Mostly moderate damages were observed in the cities of Pernik and Sofia and their surroundings. These observations could be assumed indicative for a very low rupture velocity. The low rupture velocity can mean slow-faulting, which brings to slow release of accumulated seismic energy. The slow release energy does principally little to moderate damages. Additionally wave form of the earthquake shows low frequency content of P-waves (the maximum P-wave is at 1.19 Hz) and the specific P- wave displacement spectral is characterise with not expressed spectrum plateau and corner frequency. These and other signs suggest us to the conclusion, that the 2012 Mw5.6 earthquake can be considered as types of slow earthquake, like a low frequency quake. The study is based on data from Bulgarian seismological network (NOTSSI), the local network (LSN) deployed around Kozloduy NPP and System of Accelerographs for Seismic Monitoring of Equipment and Structures (SASMES) installed in the Kozloduy NPP. NOTSSI jointly with LSN and SASMES provide reliable information for multiple studies on seismicity in regional scale.

Fast and slow spindles during the sleep slow oscillation: disparate coalescence and engagement in memory processing.

PubMed

Mölle, Matthias; Bergmann, Til O; Marshall, Lisa; Born, Jan

2011-10-01

Thalamo-cortical spindles driven by the up-state of neocortical slow (< 1 Hz) oscillations (SOs) represent a candidate mechanism of memory consolidation during sleep. We examined interactions between SOs and spindles in human slow wave sleep, focusing on the presumed existence of 2 kinds of spindles, i.e., slow frontocortical and fast centro-parietal spindles. Two experiments were performed in healthy humans (24.5 ± 0.9 y) investigating undisturbed sleep (Experiment I) and the effects of prior learning (word paired associates) vs. non-learning (Experiment II) on multichannel EEG recordings during sleep. Only fast spindles (12-15 Hz) were synchronized to the depolarizing SO up-state. Slow spindles (9-12 Hz) occurred preferentially at the transition into the SO down-state, i.e., during waning depolarization. Slow spindles also revealed a higher probability to follow rather than precede fast spindles. For sequences of individual SOs, fast spindle activity was largest for "initial" SOs, whereas SO amplitude and slow spindle activity were largest for succeeding SOs. Prior learning enhanced this pattern. The finding that fast and slow spindles occur at different times of the SO cycle points to disparate generating mechanisms for the 2 kinds of spindles. The reported temporal relationships during SO sequences suggest that fast spindles, driven by the SO up-state feed back to enhance the likelihood of succeeding SOs together with slow spindles. By enforcing such SO-spindle cycles, particularly after prior learning, fast spindles possibly play a key role in sleep-dependent memory processing.

Linear Stability of Relativistic Space-Charge Flow in a Magnetically Insulated Transmission Line Oscillator

DTIC Science & Technology

1989-04-01

MILO Magnetica fy insulated transmission line Slow-wave structure Relativistic Brillouin flow Space-charge waves Slow electromagnetic waves (over) 19... resonant layer always see a decelerating axial electric field. Consequently, field energy increases at the expense of particle energy. 17 AFWL-TR-88-103...Ve). If ve is greater than the structure coupling velocity, a resonant layer of electrons will always be present, and oscillations will occur at any

Interaction of solitons for obliquely propagating magnetoacoustic waves in stellar atmosphere

NASA Astrophysics Data System (ADS)

Jahangir, R.; Masood, W.; Siddiq, M.; Batool, Nazia

2016-12-01

We study here the nonlinear oblique propagation of magnetoacoustic waves in dense plasmas with degenerate electrons by deriving Kadomtsev-Petviashvili (KP) equation for small but finite amplitude perturbations. The two soliton interaction has been studied by finding the solution of the KP equation using the Hirota bilinear formalism. For illustrative purposes, we have used the plasma parameters typically found in white dwarf stars for both the fast and slow modes of magnetoacoustic waves. It has been observed that the soliton interaction in the fast and slow modes is strongly influenced by the predominant and weak dispersive coefficients of the KP equation. The single soliton behavior has also been explained for the fast and slow magnetoacoustic modes.

Measurement of anal pressure and motility.

PubMed Central

Hancock, B D

1976-01-01

A fine open perfused system and a closed balloon system for the measurement of anal pressure and motility have been compared. Measurements were made in 40 normal subjects and 84 patients with haemorrhoids. The rate of perfusion had a marked effect on the recorded pressure and motility details. The motility pattern was seen most clearly with the balloon probe and the pressure recorded was reproducible and easy to measure, making this a convenient method for recording activity of the internal anal sphincter. Anal motility in normal subjects was characterised by slow pressure waves (10-20/min). The frequency was fastest in the distal anal canal and this frequency gradient may represent a normal mechanism to keep the anal canal empty. Ultra slow pressure waves (0-6-1-9/min) were seen in 42% of patients with haemorrhoids and 5% of normal subjects and arose from a synchronous contraction of the whole internal sphincter. Images Fig. 1 PMID:976803

The actions of dihydroxyphenylalanine and dihydroxyphenylserine on the sleep-wakefulness cycle of the rat after peripheral decarboxylase inhibition.

PubMed Central

Altier, H; Moldes, M; Monti, J M

1975-01-01

1. The actions of dihydroxyphenylalanine (DOPA) and dihydroxyphenylserine (DOPS) were assessed on the sleep-wakefulness cycle of male Wistar rats. 2. In comparative studies the extracerebral decarboxylase was inhibited with serinetrihydroxybenzylhydrazide (RO 4-4602) before injection of DOPA or DOPS. 3. DOPA (80-160 mg/kg, i.p.) with or without previous inhibition of the peripheral decarboxylase gave rise to an initial significant increase of slow wave activity, which may be related to a release of 5-hydroxytryptamine. 4. During the subsequent 8 h sessions, DOPA significantly decreased slow wave sleep and rapid eye movement sleep (REM) and increased wakefulness. 5. DOPS (80-160 mg/kg, i.p.) did not significantly modify the sleep-wakefulness cycle apart from a decrease of the latency for the first REM episode after 160 mg/kg in the RO 4-4602 pretreated animals. PMID:166716

Reactivation of emergent task-related ensembles during slow-wave sleep after neuroprosthetic learning

PubMed Central

Gulati, Tanuj; Ramanathan, Dhakshin; Wong, Chelsea; Ganguly, Karunesh

2017-01-01

Brain-Machine Interfaces can allow neural control over assistive devices. They also provide an important platform to study neural plasticity. Recent studies indicate that optimal engagement of learning is essential for robust neuroprosthetic control. However, little is known about the neural processes that may consolidate a neuroprosthetic skill. Based on the growing body of evidence linking slow-wave activity (SWA) during sleep to consolidation, we examined if there is ‘offline’ processing after neuroprosthetic learning. Using a rodent model, here we show that after successful learning, task-related units specifically experienced increased locking and coherency to SWA during sleep. Moreover, spike-spike coherence among these units was significantly enhanced. These changes were not present with poor skill acquisition or after control awake periods, demonstrating specificity of our observations to learning. Interestingly, time spent in SWA predicted performance gains. Thus, SWA appears to play a role in offline processing after neuroprosthetic learning. PMID:24997761

Modeling and Theory of RF Antenna Systems on Proto-MPEX

NASA Astrophysics Data System (ADS)

Piotrowicz, P. A.; Caneses, J. F.; Goulding, R. H.; Green, D.; Caughman, J. B. O.; Ruzic, D. N.; Proto-MPEX Team

2017-10-01

The RF wave coupling of the helicon and ICH antennas installed on the Prototype Material Plasma Exposure eXperiment (MPEX) has been explored theoretically and via a full wave model implemented in COMSOL Multiphysics. The high-density mode in Proto-MPEX has been shown to occur when exciting radial eigenmodes of the plasma column which coincides with entering a Trivelpiece Gould (TG) anti-resonant regime, therefore suppressing edge heating in favor of core power deposition. The fast wave launched by the helicon antenna has a large wavelength and travels at a steep group velocity angle with the background magnetic field; for this reason the fast wave launched by the helicon antenna efficiently couples power to the core plasma. However, the ICH heating scheme relies on a small wavelength slow wave to couple power to the core of the plasma column. Coupling slow wave power to the core of the plasma column is sensitive to the location of the Alfven resonance. The wave-vector and group velocity vector of the slow wave in this parameter regime undergoes a drastic change in behavior when approaching the Alfven resonance. Full wave simulation results and dispersion analysis will be presented with suggestions to guide experimental progress. This work was supported by the US. D.O.E. contract DE-AC05-00OR22725.

Preliminary study of slow and fast ultrasonic waves using MR images of trabecular bone phantom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Solis-Najera, S. E., E-mail: solisnajera@ciencias.unam.mx, E-mail: angel.perez@ciencias.unam.mx, E-mail: lucia.medina@ciencias.unam.mx; Neria-Pérez, J. A., E-mail: solisnajera@ciencias.unam.mx, E-mail: angel.perez@ciencias.unam.mx, E-mail: lucia.medina@ciencias.unam.mx; Medina, L., E-mail: solisnajera@ciencias.unam.mx, E-mail: angel.perez@ciencias.unam.mx, E-mail: lucia.medina@ciencias.unam.mx

Cancellous bone is a complex tissue that performs physiological and biomechanical functions in all vertebrates. It is made up of trabeculae that, from a simplified structural viewpoint, can be considered as plates and beams in a hyperstatic structure that change with time leading to osteoporosis. Several methods has been developed to study the trabecular bone microstructure among them is the Biot’s model which predicts the existence of two longitudinal waves in porous media; the slow and the fast waves, that can be related to porosity of the media. This paper is focused on the experimental detection of the two Biot’smore » waves of a trabecular bone phantom, consisting of a trabecular network of inorganic hydroxyapatite. Experimental measurements of both waves were performed using through transmission ultrasound. Results had shown clearly that the propagation of two waves propagation is transversal to the trabecular alignment. Otherwise the waves are overlapped and a single wave seems to be propagated. To validate these results, magnetic resonance images were acquired to assess the trabecular direction, and to assure that the pulses correspond to the slow and fast waves. This approach offers a methodology for non-invasive studies of trabecular bones.« less

Evidence of Biot Slow Waves in Electroseismic Measurementss on Laboratory-Scale

NASA Astrophysics Data System (ADS)

Devi, M. S.

2015-12-01

Electroseismic methods which are the opposite of seismo-electric methods have only been little investigated up to now especially in the near surface scale. These methods can generate the solid-fluid relative movement induced by the electric potential in fluid-filled porous media. These methods are the response of electro-osmosis due to the presence of the electrical double layer. Laboratory experiments and numerical simulations of electroseismic studies have been performed. Electroseismic measurements conducted in micro glass beads saturated with demineralized water. Pair of 37 x 37 mm square aluminium grids with 2 mm of aperture and 4 mm of spacing is used as the electric dipole that connected to the electric power source with the voltage output 150 V. A laser doppler vibrometer is the system used to measure velocity of vibrating objects during measurements by placing a line of reflective paper on the surface of media that scattered back a helium-neon laser. The results in homogeneous media shows that the compressional waves induced by an electric signal. We confirm that the results are not the effects of thermal expansion. We also noticed that there are two kinds of the compressional waves are recorded: fast and slow P-waves. The latter, Biot slow waves, indicate the dominant amplitude. Moreover, we found that the transition frequency (ωc) of Biot slow waves depends on mechanical parameters such as porosity and permeability. The ωc is not affected when varying conductivity of the fluid from 25 - 320 μS/cm, although the amplitude slightly changed. For the results in two layer media by placing a sandstone as a top layer shows that a large amount of transmission seismic waves (apparently as Biot slow waves) rather than converted electromagnetic-to-seismic waves. These properties have also been simulated with full waveform numerical simulations relying on Pride's (1994) using our computer code (Garambois & Dietrich, 2002). If it is true that the electric source in the safe voltage range generates seismic waves dominantly, it may be a reason of electro-osmosis dewatering technique to transport liquids. And this source may be used an alternative as a seismic source in geophysical exploration.

Sound-Induced Intracellular Ca2+ Dynamics in the Adult Hearing Cochlea

PubMed Central

Chan, Dylan K.; Rouse, Stephanie L.

2016-01-01

Ca2+ signaling has been implicated in the initial pathophysiologic mechanisms underlying the cochlea's response to acoustic overstimulation. Intracellular Ca2+ signaling (ICS) waves, which occur in glia and retinal cells in response to injury to activate cell regulatory pathways, have been proposed as an early event in cochlear injury. Disruption of ICS activity is thought to underlie Connexin 26-associated hearing loss, the most common genetic form of deafness, and downstream sequelae of ICS wave activity, such as MAP kinase pathway activation, have been implicated in noise-induced hearing loss. However, ICS waves have only been observed in neonatal cochlear cultures and are thought to be quiescent after the onset of hearing. In this study, we employ an acute explant model of an adult, hearing cochlea that retains many in vivo physiologic features to investigate Ca2+ changes in response to sound. We find that both slow monotonic changes in intracellular Ca2+ concentration as well as discrete ICS waves occur with acoustic overstimulation. The ICS waves share many intrinsic features with their better-described neonatal counterparts, including ATP and gap-junction dependence, and propagation velocity and distance. This identification of ICS wave activity in the adult, hearing cochlea thus confirms and characterizes an important early detection mechanism for cochlear trauma and provides a target for interventions for noise-induced and Connexin 26-associated hearing loss. PMID:27959894

Relationship between delta power and the electrocardiogram-derived cardiopulmonary spectrogram: possible implications for assessing the effectiveness of sleep.

PubMed

Thomas, Robert Joseph; Mietus, Joseph E; Peng, Chung-Kang; Guo, Dan; Gozal, David; Montgomery-Downs, Hawley; Gottlieb, Daniel J; Wang, Cheng-Yen; Goldberger, Ary L

2014-01-01

The physiologic relationship between slow-wave activity (SWA) (0-4 Hz) on the electroencephalogram (EEG) and high-frequency (0.1-0.4 Hz) cardiopulmonary coupling (CPC) derived from electrocardiogram (ECG) sleep spectrograms is not known. Because high-frequency CPC appears to be a biomarker of stable sleep, we tested the hypothesis that that slow-wave EEG power would show a relatively fixed-time relationship to periods of high-frequency CPC. Furthermore, we speculated that this correlation would be independent of conventional nonrapid eye movement (NREM) sleep stages. We analyzed selected datasets from an archived polysomnography (PSG) database, the Sleep Heart Health Study I (SHHS-I). We employed the cross-correlation technique to measure the degree of which 2 signals are correlated as a function of a time lag between them. Correlation analyses between high-frequency CPC and delta power (computed both as absolute and normalized values) from 3150 subjects with an apnea-hypopnea index (AHI) of ≤5 events per hour of sleep were performed. The overall correlation (r) between delta power and high-frequency coupling (HFC) power was 0.40±0.18 (P=.001). Normalized delta power provided improved correlation relative to absolute delta power. Correlations were somewhat reduced in the second half relative to the first half of the night (r=0.45±0.20 vs r=0.34±0.23). Correlations were only affected by age in the eighth decade. There were no sex differences and only small racial or ethnic differences were noted. These results support a tight temporal relationship between slow wave power, both within and outside conventional slow wave sleep periods, and high frequency cardiopulmonary coupling, an ECG-derived biomarker of "stable" sleep. These findings raise mechanistic questions regarding the cross-system integration of neural and cardiopulmonary control during sleep. Copyright © 2013 Elsevier B.V. All rights reserved.

Enhancing Slow Wave Sleep with Sodium Oxybate Reduces the Behavioral and Physiological Impact of Sleep Loss

PubMed Central

Walsh, James K.; Hall-Porter, Janine M.; Griffin, Kara S.; Dodson, Ehren R.; Forst, Elizabeth H.; Curry, Denise T.; Eisenstein, Rhody D.; Schweitzer, Paula K.

2010-01-01

Study Objectives: To investigate whether enhancement of slow wave sleep (SWS) with sodium oxybate reduces the impact of sleep deprivation. Design: Double-blind, parallel group, placebo-controlled design Setting: Sleep research laboratory Participants: Fifty-eight healthy adults (28 placebo, 30 sodium oxybate), ages 18-50 years. Interventions: A 5-day protocol included 2 screening/baseline nights and days, 2 sleep deprivation nights, each followed by a 3-h daytime (08:00-11:00) sleep opportunity and a recovery night. Sodium oxybate or placebo was administered prior to each daytime sleep period. Multiple sleep latency test (MSLT), psychomotor vigilance test (PVT), Karolinska Sleepiness Scale (KSS), and Profile of Mood States were administered during waking hours. Measurements and Results: During daytime sleep, the sodium oxybate group had more SWS, more EEG spectral power in the 1-9 Hz range, and less REM. Mean MSLT latency was longer for the sodium oxybate group on the night following the first daytime sleep period and on the day following the second day sleep period. Median PVT reaction time was faster in the sodium oxybate group following the second day sleep period. The change from baseline in SWS was positively correlated with the change in MSLT and KSS. During recovery sleep the sodium oxybate group had less TST, SWS, REM, and slow wave activity (SWA) than the placebo group. Conclusions: Pharmacological enhancement of SWS with sodium oxybate resulted in a reduced response to sleep loss on measures of alertness and attention. In addition, SWS enhancement during sleep restriction appears to result in a reduced homeostatic response to sleep loss. Citation: Walsh JK; Hall-Porter JM; Griffin KS; Dodson ER; Forst EH; Curry DT; Eisenstein RD; Schweitzer PK. Enhancing slow wave sleep with sodium oxybate reduces the behavioral and physiological impact of sleep loss. SLEEP 2010;33(9):1217-1225. PMID:20857869

Simultaneous Anterior and Posterior Serosal Mapping of Gastric Slow Wave Dysrhythmias Induced by Vasopressin

PubMed Central

Du, Peng; O'Grady, Greg; Paskaranandavadivel, Niranchan; Tang, Shou-jiang; Abell, Thomas; Cheng, Leo K

2016-01-01

Background High-resolution (HR) mapping enables mechanistic insights into gastric slow wave dysrhythmias and is now achieving clinical translation. However, previous studies have focused mainly on dysrhythmias occurring on the anterior gastric wall. The present study simultaneously mapped the anterior and posterior gastric serosa during episodes of dysrhythmias induced by vasopressin to aid understanding of dysrhythmia initiation, maintenance and termination.. Methods HR mapping (8×16 electrodes on each serosa; 20-74 cm2) was performed in anesthetized subjects. Baseline recordings (21±8 min) were followed by intravenous vasopressin infusion (0.1-0.5 IU/mL at 60-190 mL/hour) and further recordings (22±13 min). Slow wave activation maps, amplitudes, velocity, interval, and frequency were calculated, and differences compared between baseline and post-infusion. Results All subjects demonstrated and increased prevalence of dysrhythmic events following infusion of vasopressin (17% vs 51%).Both amplitude and velocity demonstrated significant differences (baseline vs. post-infusion: 3.6 vs. 2.2 mV; 7.7 vs. 6.5 mm s−1; P < 0.05 for both). Dysrhythmias occurred simultaneously or independently on anterior and posterior serosa, and then interacted according to frequency dynamics. A number of persistent dysrhythmias were compared, including: ectopic activation (n=2 subjects), conduction block (n=1), rotor (n=2), retrograde (n=3), collision/merge of wavefronts (n=2). Conclusions Infusion of vasopressin induces gastric dysrhythmias, which occurred across a heterogeneous range of frequencies and patterns. The results demonstrated that different classes of gastric dysrhythmias may arise simultaneously or independently in one or both surfaces of the serosa, then interact according to their relative frequencies. These results will help inform clinical dysrhythmia interpretations. PMID:27265885

Effects of Tiagabine on Slow Wave Sleep and Arousal Threshold in Patients With Obstructive Sleep Apnea.

PubMed

Taranto-Montemurro, Luigi; Sands, Scott A; Edwards, Bradley A; Azarbarzin, Ali; Marques, Melania; de Melo, Camila; Eckert, Danny J; White, David P; Wellman, Andrew

2017-02-01

Obstructive sleep apnea (OSA) severity is markedly reduced during slow-wave sleep (SWS) even in patients with a severe disease. The reason for this improvement is uncertain but likely relates to non-anatomical factors (i.e. reduced arousability, chemosensitivity, and increased dilator muscle activity). The anticonvulsant tiagabine produces a dose-dependent increase in SWS in subjects without OSA. This study aimed to test the hypothesis that tiagabine would reduce OSA severity by raising the overall arousal threshold during sleep. After a baseline physiology night to assess patients' OSA phenotypic traits, a placebo-controlled, double-blind, crossover trial of tiagabine 12 mg administered before sleep was performed in 14 OSA patients. Under each condition, we assessed the effects on sleep and OSA severity using standard clinical polysomnography. Tiagabine increased slow-wave activity (SWA) of the electroencephalogram (1-4 Hz) compared to placebo (1.8 [0.4] vs. 2.0 [0.5] LogμV2, p = .04) but did not reduce OSA severity (apnea-hypopnea index [AHI] 41.5 [20.3] vs. 39.1 [16.5], p > .5). SWS duration (25 [20] vs. 26 [43] mins, p > .5) and arousal threshold (-26.5 [5.0] vs. -27.6 [5.1] cmH2O, p = .26) were also unchanged between nights. Tiagabine modified sleep microstructure (increase in SWA) but did not change the duration of SWS, OSA severity, or arousal threshold in this group of OSA patients. Based on these findings, tiagabine should not be considered as a therapeutic option for OSA treatment. © Sleep Research Society 2016. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

Sleep in the domestic hen (Gallus domesticus).

PubMed

van Luijtelaar, E L; van der Grinten, C P; Blokhuis, H J; Coenen, A M

1987-01-01

Electrophysiological recordings were made of five closely observed hens, all permanently implanted with both EEG and EMG electrodes. Five behavioural postures were distinguished and percentages of wakefulness, sleep and presumably paradoxical sleep (PS) were determined during the third and sixth hour of the dark period. Substantial agreement was generally found between behaviour and sleep with the exception of sitting or standing motionless with at least one eye open. During two thirds of this behavioural posture, the EEG showed large amplitude slow waves undistinguishable from slow wave sleep. Characteristics of PS were determined: periods were short, whereas its percentage increased during the night. Furthermore, EMG atonia was never found. An all night recording was made, and delta activity (2-5 Hz) was filtered and plotted against time for three of the hens. A significant decrease in delta activity across the night was found. Differences and similarities between sleep in hens and in mammals are discussed. Although large similarities exist it is concluded that some properties of birds' sleep make it unique and are a challenge for further study.

Convectively coupled equatorial waves within the MJO during CINDY/DYNAMO: slow Kelvin waves as building blocks

NASA Astrophysics Data System (ADS)

Kikuchi, Kazuyoshi; Kiladis, George N.; Dias, Juliana; Nasuno, Tomoe

2018-06-01

This study examines the relationship between the MJO and convectively coupled equatorial waves (CCEWs) during the CINDY2011/DYNAMO field campaign using satellite-borne infrared radiation data, in order to better understand the interaction between convection and the large-scale circulation. The spatio-temporal wavelet transform (STWT) enables us to document the convective signals within the MJO envelope in terms of CCEWs in great detail, through localization of space-time spectra at any given location and time. Three MJO events that occurred in October, November, and December 2011 are examined. It is, in general, difficult to find universal relationships between the MJO and CCEWs, implying that MJOs are diverse in terms of the types of disturbances that make up its convective envelope. However, it is found in all MJO events that the major convective body of the MJO is made up mainly by slow convectively coupled Kelvin waves. These Kelvin waves have relatively fast phase speeds of 10-13 m s-1 outside of, and slow phase speeds of 8-9 m s-1 within the MJO. Sometimes even slower eastward propagating signals with 3-5 m s-1 phase speed show up within the MJO, which, as well as the slow Kelvin waves, appear to comprise major building blocks of the MJO. It is also suggested that these eastward propagating waves often occur coincident with n = 1 WIG waves, which is consistent with the schematic model from Nakazawa in 1988. Some practical aspects that facilitate use of the STWT are also elaborated upon and discussed.

Ascent to moderate altitude impairs overnight memory improvements.

PubMed

Tesler, Noemi; Latshang, Tsogyal D; Lo Cascio, Christian M; Stadelmann, Katrin; Stoewhas, Anne-Christin; Kohler, Malcolm; Bloch, Konrad E; Achermann, Peter; Huber, Reto

2015-02-01

Several studies showed beneficial effects of sleep on memory performance. Slow waves, the electroencephalographic characteristic of deep sleep, reflected on the neuronal level by synchronous slow oscillations, seem crucial for these benefits. Traveling to moderate altitudes decreases deep sleep. In a randomized cross-over design healthy male subjects performed a visuo-motor learning task in Zurich (490 m) and at Davos Jakobshorn (2590 m) in random order. Memory performance was assessed immediately after learning, before sleep, and in the morning after a night of sleep. Sleep EEG recordings were performed during the nights. Our findings show an altitude induced reduction of sleep dependent memory performance. Moreover, this impaired sleep dependent memory performance was associated with reduced slow wave derived measures of neuronal synchronization. Our results are consistent with a critical role of slow waves for the beneficial effects of sleep on memory that is susceptible to natural environmental influences. Copyright © 2014 Elsevier Inc. All rights reserved.

Excitation of slow waves in front of an ICRF antenna in a basic plasma experiment

NASA Astrophysics Data System (ADS)

Soni, Kunal; van Compernolle, Bart; Crombe, Kristel; van Eester, Dirk

2017-10-01

Recent results of ICRF experiments at the Large Plasma Device (LAPD) indicate parasitic coupling to the slow wave by the fast wave antenna. Plasma parameters in LAPD are similar to the scrape-off layer of current fusion devices. The machine has a 17 m long, 60 cm diameter magnetized plasma column with typical plasma parameters ne 1012 -1013 cm-3, Te 1 - 10 eV and B0 1000 G. It was found that coupling to the slow mode occurs when the plasma density in front of the antenna is low enough such that the lower hybrid resonance is present in the plasma. The radial density profile is tailored to allow for fast mode propagation in the high density core and slow mode propagation in the low density edge region. Measurements of the wave fields clearly show two distinct modes, one long wavelength m=1 fast wave mode in the core and a short wavelength backward propagating mode in the edge. Perpendicular wave numbers compare favorably to the predicted values. The experiment was done for varying frequencies, ω /Ωi = 25 , 6 and 1.5. Future experiments will investigate the dependence on antenna tilt angle with respect to the magnetic field, with and without Faraday screen. This work is performed at the Basic Plasma Science Facility, sponsored jointly by DOE and NSF.

Implementation of dispersion-free slow acoustic wave propagation and phase engineering with helical-structured metamaterials

PubMed Central

Zhu, Xuefeng; Li, Kun; Zhang, Peng; Zhu, Jie; Zhang, Jintao; Tian, Chao; Liu, Shengchun

2016-01-01

The ability to slow down wave propagation in materials has attracted significant research interest. A successful solution will give rise to manageable enhanced wave–matter interaction, freewheeling phase engineering and spatial compression of wave signals. The existing methods are typically associated with constructing dispersive materials or structures with local resonators, thus resulting in unavoidable distortion of waveforms. Here we show that, with helical-structured acoustic metamaterials, it is now possible to implement dispersion-free sound deceleration. The helical-structured metamaterials present a non-dispersive high effective refractive index that is tunable through adjusting the helicity of structures, while the wavefront revolution plays a dominant role in reducing the group velocity. Finally, we numerically and experimentally demonstrate that the helical-structured metamaterials with designed inhomogeneous unit cells can turn a normally incident plane wave into a self-accelerating beam on the prescribed parabolic trajectory. The helical-structured metamaterials will have profound impact to applications in explorations of slow wave physics. PMID:27198887

Gastric electrical stimulation with short pulses reduces vomiting but not dysrhythmias in dogs.

PubMed

Chen, Jiande D Z; Qian, Liwei; Ouyang, Hui; Yin, Jieyun

2003-02-01

The aim of this study was to investigate the acute effects of 3 different methods of electrical stimulation in the prevention of vasopressin-induced emetic response and gastric dysrhythmias. Seven female hound dogs chronically implanted with 4 pairs of electrodes on gastric serosa were used in a 5-session study. Saline and vasopressin were infused in sessions 1 and 2, respectively. In the other 3 sessions with vasopressin infusion, 3 different methods of electrical stimulation (short-pulse stimulation, long-pulse stimulation, and electroacupuncture) were applied. Gastric slow waves and vomiting and behaviors suggestive of nausea were recorded in each session. In a separate study, additional experiments were performed in 5 vagotomized dogs to investigate vagally mediated mechanisms. Vasopressin induced gastric dysrhythmias, uncoupling of slow waves, and vomiting and behaviors suggestive of nausea (P < 0.02, analysis of variance). Long-pulse stimulation, but not short-pulse stimulation or electroacupuncture, was capable of preventing vasopressin-induced gastric dysrhythmias and gastric slow wave uncoupling. Short-pulse stimulation and electroacupuncture, but not long-pulse stimulation, prevented vomiting and significantly reduced the symptom scores, which was not noted in the dogs with truncal vagotomy. Long-pulse stimulation normalizes vasopressin-induced slow wave abnormalities with no improvement in vomiting and behaviors suggestive of nausea. Short-pulse stimulation and electroacupuncture prevent vomiting and behaviors suggestive of nausea induced by vasopressin but have no effects on slow waves, and their effects are vagally mediated.

Are corticothalamic 'up' states fragments of wakefulness?

PubMed

Destexhe, Alain; Hughes, Stuart W; Rudolph, Michelle; Crunelli, Vincenzo

2007-07-01

The slow (<1 Hz) oscillation, with its alternating 'up' and 'down' states in individual neurons, is a defining feature of the electroencephalogram (EEG) during slow-wave sleep (SWS). Although this oscillation is well preserved across mammalian species, its physiological role is unclear. Electrophysiological and computational evidence from the cortex and thalamus now indicates that slow-oscillation 'up' states and the 'activated' state of wakefulness are remarkably similar dynamic entities. This is consistent with behavioural experiments suggesting that slow-oscillation 'up' states provide a context for the replay, and possible consolidation, of previous experience. In this scenario, the T-type Ca(2+) channel-dependent bursts of action potentials that initiate each 'up' state in thalamocortical (TC) neurons might function as triggers for synaptic and cellular plasticity in corticothalamic networks. This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com).

Insufficient non-REM sleep intensity in narcolepsy-cataplexy.

PubMed

Khatami, Ramin; Landolt, Hans-Peter; Achermann, Peter; Rétey, Julia V; Werth, Esther; Mathis, Johannes; Bassetti, Claudio L

2007-08-01

To compare electroencephalogram (EEG) dynamics during nocturnal sleep in patients with narcolepsy-cataplexy and healthy controls. Fragmented nocturnal sleep is a prominent feature and contributes to excessive daytime sleepiness in narcolepsy-cataplexy. Only 3 studies have addressed changes in homeostatic sleep regulation as a possible mechanism underlying nocturnal sleep fragmentation in narcolepsy-cataplexy. Baseline sleep of 11 drug-naive patients with narcolepsy-cataplexy (19-37 years) and 11 matched controls (18-41 years) was polysomnographically recorded. The EEG was subjected to spectral analysis. None, baseline condition. All patients with narcolepsy-cataplexy but no control subjects showed a sleep-onset rapid eye movement (REM) episode. Non-REM (NREM)-REM sleep cycles were longer in patients with narcolepsy-cataplexy than in controls (P = 0.04). Mean slow-wave activity declined in both groups across the first 3 NREM sleep episodes (P<0.001). The rate of decline, however, appeared to be steeper in patients with narcolepsy-cataplexy (time constant: narcolepsy-cataplexy 51.1 +/- 23.8 minutes [mean +/- SEM], 95% confidence interval [CI]: 33.4-108.8 minutes) than in controls (169.4 +/- 81.5 minutes, 95% CI: 110.9-357.6 minutes) as concluded from nonoverlapping 95% confidence interval of the time constants. The steeper decline of SWA in narcolepsy-cataplexy compared to controls was related to an impaired build-up of slow-wave activity in the second cycle. Sleep in the second cycle was interrupted in patients with narcolepsy-cataplexy, when compared with controls, by an increased number (P = 0.01) and longer duration (P = 0.01) of short wake episodes. Insufficient NREM sleep intensity is associated with nonconsolidated nocturnal sleep in narcolepsy-cataplexy. The inability to consolidate sleep manifests itself when NREM sleep intensity has decayed below a certain level and is reflected in an altered time course of slow-wave activity across NREM sleep episodes.

Porous medium acoustics of wave-induced vorticity diffusion

NASA Astrophysics Data System (ADS)

Müller, T. M.; Sahay, P. N.

2011-02-01

A theory for attenuation and dispersion of elastic waves due to wave-induced generation of vorticity at pore-scale heterogeneities in a macroscopically homogeneous porous medium is developed. The diffusive part of the vorticity field associated with a viscous wave in the pore space—the so-called slow shear wave—is linked to the porous medium acoustics through incorporation of the fluid strain rate tensor of a Newtonian fluid in the poroelastic constitutive relations. The method of statistical smoothing is then used to derive dynamic-equivalent elastic wave velocities accounting for the conversion scattering process into the diffusive slow shear wave in the presence of randomly distributed pore-scale heterogeneities. The result is a simple model for wave attenuation and dispersion associated with the transition from viscosity- to inertia-dominated flow regime.

Signatures of Nonlinear Waves in Coronal Plumes and Holes

NASA Technical Reports Server (NTRS)

Ofman, Leon

1999-01-01

In recent Ultraviolet Coronagraph Spectrometer/Solar and Heliospheric Observatory (UVCS/SOHO) White Light Channel (WLC) observations we found quasi-periodic variations in the polarized brightness (pB) in the polar coronal holes at heliocentric distances of 1.9-2.45 solar radii. The motivation for the observation is the 2.5D Magnetohydrodynamics (MHD) model of solar wind acceleration by nonlinear waves, that predicts compressive fluctuations in coronal holes. To help identify the waves observed with the UVCS/WLC we model the propagation and dissipation of slow magnetosonic waves in polar plumes using 1D MHD code in spherical geometry, We find that the slow waves nonlinearly steepen in the gravitationally stratified plumes. The nonlinear steepening of the waves leads to enhanced dissipation due to compressive viscosity at the wave-fronts.

Collective synchronization of divisions in Drosophila development

NASA Astrophysics Data System (ADS)

Vergassola, Massimo

Mitoses in the early development of most metazoans are rapid and synchronized across the entire embryo. While diffusion is too slow, in vitro experiments have shown that waves of the cell-cycle regulator Cdk1 can transfer information rapidly across hundreds of microns. However, the signaling dynamics and the physical properties of chemical waves during embryonic development remain unclear. We develop FRET biosensors for the activity of Cdk1 and the checkpoint kinase Chk1 in Drosophila embryos and exploit them to measure waves in vivo. We demonstrate that Cdk1 chemical waves control mitotic waves and that their speed is regulated by the activity of Cdk1 during the S-phase (and not mitosis). We quantify the progressive slowdown of the waves with developmental cycles and identify its underlying control mechanism by the DNA replication checkpoint through the Chk1/Wee1 pathway. The global dynamics of the mitotic signaling network illustrates a novel control principle: the S-phase activity of Cdk1 regulates the speed of the mitotic wave, while the Cdk1 positive feedback ensures an invariantly rapid onset of mitosis. Mathematical modeling captures the speed of the waves and predicts a fundamental distinction between the S-phase Cdk1 trigger waves and the mitotic phase waves, which is illustrated by embryonic ablation experiments. In collaboration with Victoria Deneke1, Anna Melbinger2, and Stefano Di Talia1 1 Department of Cell Biology, Duke University Medical Center 2 Department of Physics, University of California San Diego.

Detection and characterization of lightning-based sources using continuous wavelet transform: application to audio-magnetotellurics

NASA Astrophysics Data System (ADS)

Larnier, H.; Sailhac, P.; Chambodut, A.

2018-01-01

Atmospheric electromagnetic waves created by global lightning activity contain information about electrical processes of the inner and the outer Earth. Large signal-to-noise ratio events are particularly interesting because they convey information about electromagnetic properties along their path. We introduce a new methodology to automatically detect and characterize lightning-based waves using a time-frequency decomposition obtained through the application of continuous wavelet transform. We focus specifically on three types of sources, namely, atmospherics, slow tails and whistlers, that cover the frequency range 10 Hz to 10 kHz. Each wave has distinguishable characteristics in the time-frequency domain due to source shape and dispersion processes. Our methodology allows automatic detection of each type of event in the time-frequency decomposition thanks to their specific signature. Horizontal polarization attributes are also recovered in the time-frequency domain. This procedure is first applied to synthetic extremely low frequency time-series with different signal-to-noise ratios to test for robustness. We then apply it on real data: three stations of audio-magnetotelluric data acquired in Guadeloupe, oversea French territories. Most of analysed atmospherics and slow tails display linear polarization, whereas analysed whistlers are elliptically polarized. The diversity of lightning activity is finally analysed in an audio-magnetotelluric data processing framework, as used in subsurface prospecting, through estimation of the impedance response functions. We show that audio-magnetotelluric processing results depend mainly on the frequency content of electromagnetic waves observed in processed time-series, with an emphasis on the difference between morning and afternoon acquisition. Our new methodology based on the time-frequency signature of lightning-induced electromagnetic waves allows automatic detection and characterization of events in audio-magnetotelluric time-series, providing the means to assess quality of response functions obtained through processing.

Measurements of acoustic surface waves on fluid-filled porous rocks

NASA Astrophysics Data System (ADS)

Adler, Laszlo; Nagy, Peter B.

1994-09-01

Novel experimental techniques to measure ultrasonic velocity and attenuation of surface waves on fluid-filled porous natural rocks are presented. Our experimental results are consistent with the theoretical predictions of Feng and Johnson (1983). Depending on the interface conditions, i.e., whether the surface pores are open or closed, pseudo-Rayleigh, pseudo-Stoneley, and/or Stoneley surface waves may exist on fluid-saturated rocks with closed 'slow' surface wave (true Stoneley mode) on fluid-filled porous rocks with closed surface pores. The velocity and attenuation of the 'slow' surface mode may be used to assess the dynamic permeabilty of porous formations.

An automated sleep-state classification algorithm for quantifying sleep timing and sleep-dependent dynamics of electroencephalographic and cerebral metabolic parameters

PubMed Central

Rempe, Michael J; Clegern, William C; Wisor, Jonathan P

2015-01-01

Introduction Rodent sleep research uses electroencephalography (EEG) and electromyography (EMG) to determine the sleep state of an animal at any given time. EEG and EMG signals, typically sampled at >100 Hz, are segmented arbitrarily into epochs of equal duration (usually 2–10 seconds), and each epoch is scored as wake, slow-wave sleep (SWS), or rapid-eye-movement sleep (REMS), on the basis of visual inspection. Automated state scoring can minimize the burden associated with state and thereby facilitate the use of shorter epoch durations. Methods We developed a semiautomated state-scoring procedure that uses a combination of principal component analysis and naïve Bayes classification, with the EEG and EMG as inputs. We validated this algorithm against human-scored sleep-state scoring of data from C57BL/6J and BALB/CJ mice. We then applied a general homeostatic model to characterize the state-dependent dynamics of sleep slow-wave activity and cerebral glycolytic flux, measured as lactate concentration. Results More than 89% of epochs scored as wake or SWS by the human were scored as the same state by the machine, whether scoring in 2-second or 10-second epochs. The majority of epochs scored as REMS by the human were also scored as REMS by the machine. However, of epochs scored as REMS by the human, more than 10% were scored as SWS by the machine and 18 (10-second epochs) to 28% (2-second epochs) were scored as wake. These biases were not strain-specific, as strain differences in sleep-state timing relative to the light/dark cycle, EEG power spectral profiles, and the homeostatic dynamics of both slow waves and lactate were detected equally effectively with the automated method or the manual scoring method. Error associated with mathematical modeling of temporal dynamics of both EEG slow-wave activity and cerebral lactate either did not differ significantly when state scoring was done with automated versus visual scoring, or was reduced with automated state scoring relative to manual classification. Conclusions Machine scoring is as effective as human scoring in detecting experimental effects in rodent sleep studies. Automated scoring is an efficient alternative to visual inspection in studies of strain differences in sleep and the temporal dynamics of sleep-related physiological parameters. PMID:26366107

Computer Simulation of Microwave Devices

NASA Technical Reports Server (NTRS)

Kory, Carol L.

1997-01-01

The accurate simulation of cold-test results including dispersion, on-axis beam interaction impedance, and attenuation of a helix traveling-wave tube (TWT) slow-wave circuit using the three-dimensional code MAFIA (Maxwell's Equations Solved by the Finite Integration Algorithm) was demonstrated for the first time. Obtaining these results is a critical step in the design of TWT's. A well-established procedure to acquire these parameters is to actually build and test a model or a scale model of the circuit. However, this procedure is time-consuming and expensive, and it limits freedom to examine new variations to the basic circuit. These limitations make the need for computational methods crucial since they can lower costs, reduce tube development time, and lessen limitations on novel designs. Computer simulation has been used to accurately obtain cold-test parameters for several slow-wave circuits. Although the helix slow-wave circuit remains the mainstay of the TWT industry because of its exceptionally wide bandwidth, until recently it has been impossible to accurately analyze a helical TWT using its exact dimensions because of the complexity of its geometrical structure. A new computer modeling technique developed at the NASA Lewis Research Center overcomes these difficulties. The MAFIA three-dimensional mesh for a C-band helix slow-wave circuit is shown.

Large-Amplitude Long-Wave Instability of a Supersonic Shear Layer

NASA Technical Reports Server (NTRS)

Messiter, A. F.

1995-01-01

For sufficiently high Mach numbers, small disturbances on a supersonic vortex sheet are known to grow in amplitude because of slow nonlinear wave steepening. Under the same external conditions, linear theory predicts slow growth of long-wave disturbances to a thin supersonic shear layer. An asymptotic formulation is given here which adds nonzero shear-layer thickness to the weakly nonlinear formulation for a vortex sheet. Spatial evolution is considered, for a spatially periodic disturbance having amplitude of the same order, in Reynolds number, as the shear-layer thickness. A quasi-equilibrium inviscid nonlinear critical layer is found, with effects of diffusion and slow growth appearing through nonsecularity condition. Other limiting cases are also considered, in an attempt to determine a relationship between the vortex-sheet limit and the long-wave limit for a thin shear layer; there appear to be three special limits, corresponding to disturbances of different amplitudes at different locations along the shear layer.

Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder

PubMed Central

Nishida, Masaki; Nakashima, Yusaku; Nishikawa, Toru

2016-01-01

Introduction Evidence has accumulated, which indicates that, in healthy individuals, sleep enhances procedural memory consolidation, and that sleep spindle activity modulates this process. However, whether sleep-dependent procedural memory consolidation occurs in patients medicated for major depressive disorder remains unclear, as are the pharmacological and physiological mechanisms that underlie this process. Methods Healthy control participants (n=17) and patients medicated for major depressive disorder (n=11) were recruited and subjected to a finger-tapping motor sequence test (MST; nondominant hand) paradigm to compare the averaged scores of different learning phases (presleep, postsleep, and overnight improvement). Participants’ brain activity was recorded during sleep with 16 electroencephalography channels (between MSTs). Sleep scoring and frequency analyses were performed on the electroencephalography data. Additionally, we evaluated sleep spindle activity, which divided the spindles into fast-frequency spindle activity (12.5–16 Hz) and slow-frequency spindle activity (10.5–12.5 Hz). Result Sleep-dependent motor memory consolidation in patients with depression was impaired in comparison with that in control participants. In patients with depression, age correlated negatively with overnight improvement. The duration of slow-wave sleep correlated with the magnitude of motor memory consolidation in patients with depression, but not in healthy controls. Slow-frequency spindle activity was associated with reduction in the magnitude of motor memory consolidation in both groups. Conclusion Because the changes in slow-frequency spindle activity affected the thalamocortical network dysfunction in patients medicated for depression, dysregulated spindle generation may impair sleep-dependent memory consolidation. Our findings may help to elucidate the cognitive deficits that occur in patients with major depression both in the waking state and during sleep. PMID:26869818

Physics of ultrasonic wave propagation in bone and heart characterized using Bayesian parameter estimation

NASA Astrophysics Data System (ADS)

Anderson, Christian Carl

This Dissertation explores the physics underlying the propagation of ultrasonic waves in bone and in heart tissue through the use of Bayesian probability theory. Quantitative ultrasound is a noninvasive modality used for clinical detection, characterization, and evaluation of bone quality and cardiovascular disease. Approaches that extend the state of knowledge of the physics underpinning the interaction of ultrasound with inherently inhomogeneous and isotropic tissue have the potential to enhance its clinical utility. Simulations of fast and slow compressional wave propagation in cancellous bone were carried out to demonstrate the plausibility of a proposed explanation for the widely reported anomalous negative dispersion in cancellous bone. The results showed that negative dispersion could arise from analysis that proceeded under the assumption that the data consist of only a single ultrasonic wave, when in fact two overlapping and interfering waves are present. The confounding effect of overlapping fast and slow waves was addressed by applying Bayesian parameter estimation to simulated data, to experimental data acquired on bone-mimicking phantoms, and to data acquired in vitro on cancellous bone. The Bayesian approach successfully estimated the properties of the individual fast and slow waves even when they strongly overlapped in the acquired data. The Bayesian parameter estimation technique was further applied to an investigation of the anisotropy of ultrasonic properties in cancellous bone. The degree to which fast and slow waves overlap is partially determined by the angle of insonation of ultrasound relative to the predominant direction of trabecular orientation. In the past, studies of anisotropy have been limited by interference between fast and slow waves over a portion of the range of insonation angles. Bayesian analysis estimated attenuation, velocity, and amplitude parameters over the entire range of insonation angles, allowing a more complete characterization of anisotropy. A novel piecewise linear model for the cyclic variation of ultrasonic backscatter from myocardium was proposed. Models of cyclic variation for 100 type 2 diabetes patients and 43 normal control subjects were constructed using Bayesian parameter estimation. Parameters determined from the model, specifically rise time and slew rate, were found to be more reliable in differentiating between subject groups than the previously employed magnitude parameter.

Understanding Epileptiform After-Discharges as Rhythmic Oscillatory Transients.

PubMed

Baier, Gerold; Taylor, Peter N; Wang, Yujiang

2017-01-01

Electro-cortical activity in patients with epilepsy may show abnormal rhythmic transients in response to stimulation. Even when using the same stimulation parameters in the same patient, wide variability in the duration of transient response has been reported. These transients have long been considered important for the mapping of the excitability levels in the epileptic brain but their dynamic mechanism is still not well understood. To investigate the occurrence of abnormal transients dynamically, we use a thalamo-cortical neural population model of epileptic spike-wave activity and study the interaction between slow and fast subsystems. In a reduced version of the thalamo-cortical model, slow wave oscillations arise from a fold of cycles (FoC) bifurcation. This marks the onset of a region of bistability between a high amplitude oscillatory rhythm and the background state. In vicinity of the bistability in parameter space, the model has excitable dynamics, showing prolonged rhythmic transients in response to suprathreshold pulse stimulation. We analyse the state space geometry of the bistable and excitable states, and find that the rhythmic transient arises when the impending FoC bifurcation deforms the state space and creates an area of locally reduced attraction to the fixed point. This area essentially allows trajectories to dwell there before escaping to the stable steady state, thus creating rhythmic transients. In the full thalamo-cortical model, we find a similar FoC bifurcation structure. Based on the analysis, we propose an explanation of why stimulation induced epileptiform activity may vary between trials, and predict how the variability could be related to ongoing oscillatory background activity. We compare our dynamic mechanism with other mechanisms (such as a slow parameter change) to generate excitable transients, and we discuss the proposed excitability mechanism in the context of stimulation responses in the epileptic cortex.

Rainbow trapping of ultrasonic guided waves in chirped phononic crystal plates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tian, Zhenhua; Yu, Lingyu

The rainbow trapping effect has been demonstrated in electromagnetic and acoustic waves. In this study, rainbow trapping of ultrasonic guided waves is achieved in chirped phononic crystal plates that spatially modulate the dispersion, group velocity, and stopband. The rainbow trapping is related to the progressively slowing group velocity, and the extremely low group velocity near the lower boundary of a stopband that gradually varies in chirped phononic crystal plates. As guided waves propagate along the phononic crystal plate, waves gradually slow down and finally stop forward propagating. The energy of guided waves is concentrated at the low velocity region nearmore » the stopband. Moreover, the guided wave energy of different frequencies is concentrated at different locations, which manifests as rainbow guided waves. We believe implementing the rainbow trapping will open new paradigms for guiding and focusing of guided waves. Furthermore, the rainbow guided waves with energy concentration and spatial separation of frequencies may have potential applications in nondestructive evaluation, spatial wave filtering, energy harvesting, and acoustofluidics.« less

Rainbow trapping of ultrasonic guided waves in chirped phononic crystal plates

DOE PAGES

Tian, Zhenhua; Yu, Lingyu

2017-01-05

The rainbow trapping effect has been demonstrated in electromagnetic and acoustic waves. In this study, rainbow trapping of ultrasonic guided waves is achieved in chirped phononic crystal plates that spatially modulate the dispersion, group velocity, and stopband. The rainbow trapping is related to the progressively slowing group velocity, and the extremely low group velocity near the lower boundary of a stopband that gradually varies in chirped phononic crystal plates. As guided waves propagate along the phononic crystal plate, waves gradually slow down and finally stop forward propagating. The energy of guided waves is concentrated at the low velocity region nearmore » the stopband. Moreover, the guided wave energy of different frequencies is concentrated at different locations, which manifests as rainbow guided waves. We believe implementing the rainbow trapping will open new paradigms for guiding and focusing of guided waves. Furthermore, the rainbow guided waves with energy concentration and spatial separation of frequencies may have potential applications in nondestructive evaluation, spatial wave filtering, energy harvesting, and acoustofluidics.« less

Rainbow trapping of ultrasonic guided waves in chirped phononic crystal plates.

PubMed

Tian, Zhenhua; Yu, Lingyu

2017-01-05

The rainbow trapping effect has been demonstrated in electromagnetic and acoustic waves. In this study, rainbow trapping of ultrasonic guided waves is achieved in chirped phononic crystal plates that spatially modulate the dispersion, group velocity, and stopband. The rainbow trapping is related to the progressively slowing group velocity, and the extremely low group velocity near the lower boundary of a stopband that gradually varies in chirped phononic crystal plates. As guided waves propagate along the phononic crystal plate, waves gradually slow down and finally stop forward propagating. The energy of guided waves is concentrated at the low velocity region near the stopband. Moreover, the guided wave energy of different frequencies is concentrated at different locations, which manifests as rainbow guided waves. We believe implementing the rainbow trapping will open new paradigms for guiding and focusing of guided waves. Moreover, the rainbow guided waves with energy concentration and spatial separation of frequencies may have potential applications in nondestructive evaluation, spatial wave filtering, energy harvesting, and acoustofluidics.

Reduction of nocturnal slow-wave activity affects daytime vigilance lapses and memory encoding but not reaction time or implicit learning.

PubMed

Van Der Werf, Ysbrand D; Altena, Ellemarije; Vis, José C; Koene, Teddy; Van Someren, Eus J W

2011-01-01

Total sleep deprivation in healthy subjects has a profound effect on the performance on tasks measuring sustained attention or vigilance. We here report how a selective disruption of deep sleep only, that is, selective slow-wave activity (SWA) reduction, affects the performance of healthy well-sleeping subjects on several tasks: a "simple" and a "complex" vigilance task, a declarative learning task, and an implicit learning task despite unchanged duration of sleep. We used automated electroencephalogram (EEG) dependent acoustic feedback aimed at selective interference with-and reduction of-SWA. In a within-subject repeated measures crossover design, performance on the tasks was assessed in 13 elderly adults without sleep complaints after either SWA-reduction or after normal sleep. The number of vigilance lapses increased as a result of SWA reduction, irrespective of the type of vigilance task. Recognition on the declarative memory task was also affected by SWA reduction, associated with a decreased activation of the right hippocampus on encoding (measured with fMRI) suggesting a weaker memory trace. SWA reduction, however, did not affect reaction time on either of the vigilance tasks or implicit memory task performance. These findings suggest a specific role of slow oscillations in the subsequent daytime ability to maintain sustained attention and to encode novel declarative information but not to maintain response speed or to build implicit memories. Of particular interest is that selective SWA reduction can mimic some of the effects of total sleep deprivation, while not affecting sleep duration. Copyright © 2011 Elsevier B.V. All rights reserved.

Neural Correlates of Encoding Predict Infants' Memory in the Paired-Comparison Procedure

ERIC Educational Resources Information Center

Snyder, Kelly A.

2010-01-01

The present study used event-related potentials (ERPs) to monitor infant brain activity during the initial encoding of a previously novel visual stimulus, and examined whether ERP measures of encoding predicted infants' subsequent performance on a visual memory task (i.e., the paired-comparison task). A late slow wave component of the ERP measured…

Application of oil-water discrimination technology in fractured reservoirs using the differences between fast and slow shear-waves

NASA Astrophysics Data System (ADS)

Luo, Cong; Li, Xiangyang; Huang, Guangtan

2017-08-01

Oil-water discrimination is of great significance in the design and adjustment of development projects in oil fields. For fractured reservoirs, based on anisotropic S-wave splitting information, it becomes possible to effectively solve such problems which are difficult to deal with in traditional longitudinal wave exploration, due to the similar bulk modulus and density of these two fluids. In this paper, by analyzing the anisotropic character of the Chapman model (2009 Geophysics 74 97-103), the velocity and reflection coefficient differences between the fast and slow S-wave caused by fluid substitution have been verified. Then, through a wave field response analysis of the theoretical model, we found that water saturation causes a longer time delay, a larger time delay gradient and a lower amplitude difference between the fast and slow S-wave, while the oil case corresponds to a lower time delay, a lower gradient and a higher amplitude difference. Therefore, a new class attribute has been proposed regarding the amplitude energy of the fast and slow shear wave, used for oil-water distinction. This new attribute, as well as that of the time delay gradient, were both applied to the 3D3C seismic data of carbonate fractured reservoirs in the Luojia area of the Shengli oil field in China. The results show that the predictions of the energy attributes are more consistent with the well information than the time delay gradient attribute, hence demonstrating the great advantages and potential of this new attribute in oil-water recognition.

Combined free-stream disturbance measurements and receptivity studies in hypersonic wind tunnels by means of a slender wedge probe and direct numerical simulation

NASA Astrophysics Data System (ADS)

Wagner, Alexander; Schülein, Erich; Petervari, René; Hannemann, Klaus; Ali, Syed R. C.; Cerminara, Adriano; Sandham, Neil D.

2018-05-01

Combined free-stream disturbance measurements and receptivity studies in hypersonic wind tunnels were conducted by means of a slender wedge probe and direct numerical simulation. The study comprises comparative tunnel noise measurements at Mach 3, 6 and 7.4 in two Ludwieg tube facilities and a shock tunnel. Surface pressure fluctuations were measured over a wide range of frequencies and test conditions including harsh test environments not accessible to measurement techniques such as pitot probes and hot-wire anemometry. Quantitative results of the tunnel noise are provided in frequency ranges relevant for hypersonic boundary layer transition. In combination with the experimental studies, direct numerical simulations of the leading-edge receptivity to fast and slow acoustic waves were performed for the slender wedge probe at conditions corresponding to the experimental free-stream conditions. The receptivity to fast acoustic waves was found to be characterized by an early amplification of the induced fast mode. For slow acoustic waves an initial decay was found close to the leading edge. At all Mach numbers, and for all considered frequencies, the leading-edge receptivity to fast acoustic waves was found to be higher than the receptivity to slow acoustic waves. Further, the effect of inclination angles of the acoustic wave with respect to the flow direction was investigated. The combined numerical and experimental approach in the present study confirmed the previous suggestion that the slow acoustic wave is the dominant acoustic mode in noisy hypersonic wind tunnels.

Four cavity efficiency enhanced magnetically insulated line oscillator

DOEpatents

Lemke, Raymond W.; Clark, Miles C.; Calico, Steve E.

1998-04-21

A four cavity, efficient magnetically insulated line oscillator (C4-E MILO) having seven vanes and six cavities formed within a tube-like structure surrounding a cathode. The C4-E MILO has a primary slow wave structure which is comprised of four vanes and the four cavities located near a microwave exit end of the tube-like structure. The primary slow wave structure is the four cavity (C4) portion of the magnetically insulated line oscillator (MILO). An RF choke is provided which is comprised of three of the vanes and two of the cavities. The RF choke is located near a pulsed power source portion of the tube-like structure surrounding the cathode. The RF choke increases feedback in the primary slow wave structure, prevents microwaves generated in the primary slow wave structure from propagating towards the pulsed power source and modifies downstream electron current so as to enhance microwave power generation. A beam dump/extractor is located at the exit end of the oscillator tube for extracting microwave power from the oscillator, and in conjunction with an RF extractor vane, which comprises the fourth vane of the primary slow wave structure (nearest the exit) having a larger gap radius than the other vanes of the primary SWS, comprises an RF extractor. Uninsulated electron flow is returned downstream towards the exit along an anode/beam dump region located between the beam dump/extractor and the exit where the RF is radiated at said RF extractor vane located near the exit and the uninsulated electron flow is disposed at the beam dump/extractor.

Four cavity efficiency enhanced magnetically insulated line oscillator

DOEpatents

Lemke, R.W.; Clark, M.C.; Calico, S.E.

1998-04-21

A four cavity, efficient magnetically insulated line oscillator (C4-E MILO) having seven vanes and six cavities formed within a tube-like structure surrounding a cathode is disclosed. The C4-E MILO has a primary slow wave structure which is comprised of four vanes and the four cavities located near a microwave exit end of the tube-like structure. The primary slow wave structure is the four cavity portion of the magnetically insulated line oscillator (MILO). An RF choke is provided which is comprised of three of the vanes and two of the cavities. The RF choke is located near a pulsed power source portion of the tube-like structure surrounding the cathode. The RF choke increases feedback in the primary slow wave structure, prevents microwaves generated in the primary slow wave structure from propagating towards the pulsed power source and modifies downstream electron current so as to enhance microwave power generation. A beam dump/extractor is located at the exit end of the oscillator tube for extracting microwave power from the oscillator, and in conjunction with an RF extractor vane, which comprises the fourth vane of the primary slow wave structure (nearest the exit) having a larger gap radius than the other vanes of the primary SWS, comprises an RF extractor. Uninsulated electron flow is returned downstream towards the exit along an anode/beam dump region located between the beam dump/extractor and the exit where the RF is radiated at said RF extractor vane located near the exit and the uninsulated electron flow is disposed at the beam dump/extractor. 34 figs.

Electroencephalographic Variation during End Maintenance and Emergence from Surgical Anesthesia

PubMed Central

MacColl, Jono N.; Illing, Sam; Sleigh, Jamie W.

2014-01-01

The re-establishment of conscious awareness after discontinuing general anesthesia has often been assumed to be the inverse of loss of consciousness. This is despite the obvious asymmetry in the initiation and termination of natural sleep. In order to characterize the restoration of consciousness after surgery, we recorded frontal electroencephalograph (EEG) from 100 patients in the operating room during maintenance and emergence from general anesthesia. We have defined, for the first time, 4 steady-state patterns of anesthetic maintenance based on the relative EEG power in the slow-wave (<14 Hz) frequency bands that dominate sleep and anesthesia. Unlike single-drug experiments performed in healthy volunteers, we found that surgical patients exhibited greater electroencephalographic heterogeneity while re-establishing conscious awareness after drug discontinuation. Moreover, these emergence patterns could be broadly grouped according to the duration and rapidity of transitions amongst these slow-wave dominated brain states that precede awakening. Most patients progressed gradually from a pattern characterized by strong peaks of delta (0.5–4 Hz) and alpha/spindle (8–14 Hz) power (‘Slow-Wave Anesthesia’) to a state marked by low delta-spindle power (‘Non Slow-Wave Anesthesia’) before awakening. However, 31% of patients transitioned abruptly from Slow-Wave Anesthesia to waking; they were also more likely to express pain in the post-operative period. Our results, based on sleep-staging classification, provide the first systematized nomenclature for tracking brain states under general anesthesia from maintenance to emergence, and suggest that these transitions may correlate with post-operative outcomes such as pain. PMID:25264892

A Mechanism for Upper Airway Stability during Slow Wave Sleep

PubMed Central

McSharry, David G.; Saboisky, Julian P.; DeYoung, Pam; Matteis, Paul; Jordan, Amy S.; Trinder, John; Smales, Erik; Hess, Lauren; Guo, Mengshuang; Malhotra, Atul

2013-01-01

Study Objectives: The severity of obstructive sleep apnea is diminished (sometimes markedly) during slow wave sleep (SWS). We sought to understand why SWS stabilizes the upper airway. Increased single motor unit (SMU) activity of the major upper airway dilating muscle (genioglossus) should improve upper airway stability. Therefore, we hypothesized that genioglossus SMUs would increase their activity during SWS in comparison with Stage N2 sleep. Design: The activity of genioglossus SMUs was studied on both sides of the transition between Stage N2 sleep and SWS. Setting: Sleep laboratory. Participants: Twenty-nine subjects (age 38 ± 13 yr, 17 males) were studied. Intervention: SWS. Measurement and Results: Subjects slept overnight with fine-wire electrodes in their genioglossus muscles and with full polysomnographic and end tidal carbon dioxide monitors. Fifteen inspiratory phasic (IP) and 11 inspiratory tonic (IT) units were identified from seven subjects and these units exhibited significantly increased inspiratory discharge frequencies during SWS compared with Stage N2 sleep. The peak discharge frequency of the inspiratory units (IP and IT) was 22.7 ± 4.1 Hz in SWS versus 20.3 ± 4.5 Hz in Stage N2 (P < 0.001). The IP units also fired for a longer duration (expressed as a percentage of inspiratory time) during SWS (104.6 ± 39.5 %TI) versus Stage N2 sleep (82.6 ± 39.5 %TI, P < 0.001). The IT units fired faster during expiration in SWS (14.2 ± 1.8 Hz) versus Stage N2 sleep (12.6 ± 3.1 Hz, P = 0.035). There was minimal recruitment or derecruitment of units between SWS and Stage N2 sleep. Conclusion: Increased genioglossus SMU activity likely makes the airway more stable and resistant to collapse throughout the respiratory cycle during SWS. Citation: McSharry DG; Saboisky JP; DeYoung P; Matteis P; Jordan AS; Trinder J; Smales E; Hess L; Guo M; Malhotra A. A mechanism for upper airway stability during slow wave sleep. SLEEP 2013;36(4):555-563. PMID:23565001

The effects of noise on binocular rivalry waves: a stochastic neural field model

NASA Astrophysics Data System (ADS)

Webber, Matthew A.; Bressloff, Paul C.

2013-03-01

We analyze the effects of extrinsic noise on traveling waves of visual perception in a competitive neural field model of binocular rivalry. The model consists of two one-dimensional excitatory neural fields, whose activity variables represent the responses to left-eye and right-eye stimuli, respectively. The two networks mutually inhibit each other, and slow adaptation is incorporated into the model by taking the network connections to exhibit synaptic depression. We first show how, in the absence of any noise, the system supports a propagating composite wave consisting of an invading activity front in one network co-moving with a retreating front in the other network. Using a separation of time scales and perturbation methods previously developed for stochastic reaction-diffusion equations, we then show how extrinsic noise in the activity variables leads to a diffusive-like displacement (wandering) of the composite wave from its uniformly translating position at long time scales, and fluctuations in the wave profile around its instantaneous position at short time scales. We use our analysis to calculate the first-passage-time distribution for a stochastic rivalry wave to travel a fixed distance, which we find to be given by an inverse Gaussian. Finally, we investigate the effects of noise in the depression variables, which under an adiabatic approximation lead to quenched disorder in the neural fields during propagation of a wave.

Measurement of airborne ultrasonic slow waves in calcaneal cancellous bone.

PubMed

Strelitzki, R; Paech, V; Nicholson, P H

1999-05-01

Measurements of an airborne ultrasonic wave were made in defatted cancellous bone from the human calcaneus using standard ultrasonic equipment. The wave propagating under these conditions was consistent with a decoupled Biot slow wave travelling in the air alone, as previously reported in gas-saturated foams. Reproducible measurements of phase velocity and attenuation coefficient were possible, and an estimate of the tortuosity of the trabecular framework was derived from the high frequency limit of the phase velocity. Thus the method offers a new approach to the acoustic characterisation of bone in vitro which, in contrast to existing techniques, has the potential to yield information directly characterising the trabecular structure.

Mutual information analysis and detection of interictal morphological differences in interictal epileptiform discharges of patients with partial epilepsies.

PubMed

Varma, N K; Kushwaha, R; Beydoun, A; Williams, W J; Drury, I

1997-10-01

The purpose of this paper is to compare the morphological features of interictal epileptiform discharges (IED) in patients with benign epilepsy of childhood with centrotemporal spikes to IED of those with symptomatic localization related epilepsies using information theory. Three patients from each clinical group were selected. Two-second epochs centered at the peak negativity of the sharp waves were analyzed from a referential montage during stage I sleep. The epochs from the two groups were compared using parametric and information theory analysis. Information analysis determined the likelihood of correctly identifying the clinical group based on the IED. Standard parametric, morphological and spectral analyses were also performed. We found no significant difference in the morphology of the sharp wave between the two groups. The after-going slow wave contained the greatest information that separated the two groups. This result was supported by morphological and spectral differences in the after-going slow wave. Greater distinguishing information is held in the after-going slow wave than the sharp wave for the identification of clinical groups. Information analysis may assist in differentiating clinical syndromes from EEG signals.

Manipulating Traveling Brain Waves with Electric Fields: From Theory to Experiment.

NASA Astrophysics Data System (ADS)

Gluckman, Bruce J.

2004-03-01

Activity waves in disinhibited neocortical slices have been used as a biological model for epileptic seizure propagation [1]. Such waves have been mathematically modeled with integro-differential equations [2] representing non-local reaction diffusion dynamics of an excitable medium with an excitability threshold. Stability and propagation speed of traveling pulse solutions depend strongly on the threshold in the following manner: propagation speed should decrease with increased threshold over a finite range, beyond which the waves become unstable. Because populations of neurons can be polarized with an applied electric field that effectively shifts their threshold for action potential initiation [3], we predicted, and have experimentally verified, that electric fields could be used globally or locally to speed up, slow down and even block wave propagation. [1] Telfeian and Conners, Epilepsia, 40, 1499-1506, 1999. [2] Pinto and Ermentrout, SIAM J. App. Math, 62, 206-225, 2001. [3] Gluckman, et. al. J Neurophysiol. 76, 4202-5, 1996.

Weak rotating flow disturbances in a centrifugal compressor with a vaneless diffuser

NASA Technical Reports Server (NTRS)

Moore, F. K.

1988-01-01

A theory is presented to predict the occurrence of weak rotating waves in a centrifugal compression system with a vaneless diffuser. As in a previous study of axial systems, an undisturbed performance characteristic is assumed known. Following an inviscid analysis of the diffuser flow, conditions for a neutral rotating disturbance are found. The solution is shown to have two branches; one with fast rotation, the other with very slow rotation. The slow branch includes a dense set of resonant solutions. The resonance is a feature of the diffuser flow, and therefore such disturbances must be expected at the various resonant flow coefficients regardless of the compressor characteristic. Slow solutions seem limited to flow coefficients less than about 0.3, where third and fourth harmonics appear. Fast waves seem limited to a first harmonic. These fast and slow waves are described, and effects of diffuser-wall convergence, backward blade angles, and partial recovery of exit velocity head are assessed.

Glutamate microinjection in the medial septum of rats decreases paradoxical sleep and increases slow wave sleep.

PubMed

Mukherjee, Didhiti; Kaushik, Mahesh K; Jaryal, Ashok Kumar; Kumar, Velayudhan Mohan; Mallick, Hruda Nanda

2012-05-09

The role of the medial septum in suppressing paradoxical sleep and promoting slow wave sleep was suggested on the basis of neurotoxic lesion studies. However, these conclusions need to be substantiated with further experiments, including chemical stimulation studies. In this report, the medial septum was stimulated in adult male rats by microinjection of L-glutamate. Sleep-wakefulness was electrophysiologically recorded, through chronically implanted electrodes, for 2 h before the injection and 4 h after the injection. There was a decrease in paradoxical sleep during the first hour and an increase in slow wave sleep during the second hour after the injection. The present findings not only supported the lesion studies but also showed that the major role of the medial septum is to suppress paradoxical sleep.

Tuning the group delay of optical wave packets in liquid-crystal light valves

NASA Astrophysics Data System (ADS)

Bortolozzo, U.; Residori, S.; Huignard, J. P.

2009-05-01

By performing two-wave mixing experiments in a liquid-crystal light valve, optical pulses are slowed down to group velocities as slow as a few tenths of mm/s, corresponding to a very large group index. We present experiments and model of the slow-light process occurring in the liquid-crystal light valve, showing that this is characterized by multiple-beam diffraction in the Raman-Nath regime. Depending on the initial frequency detuning between pump and signal, the different output order beams are distinguished by different group delays. The group delay can be tuned by changing the main parameters of the experiment: the detuning between the pump and the input wave packet, the strength of the nonlinearity, and the intensity of the pump beam.

Experimental observation of sub-terahertz backward-wave amplification in a multi-level microfabricated slow-wave circuit

NASA Astrophysics Data System (ADS)

Baik, Chan-Wook; Ahn, Ho Young; Kim, Yongsung; Lee, Jooho; Hong, Seogwoo; Lee, Sang Hun; Choi, Jun Hee; Kim, Sunil; Jeon, So-Yeon; Yu, SeGi; Collins, George; Read, Michael E.; Lawrence Ives, R.; Kim, Jong Min; Hwang, Sungwoo

2015-11-01

In our earlier paper dealing with dispersion retrieval from ultra-deep, reactive-ion-etched, slow-wave circuits on silicon substrates, it was proposed that splitting high-aspect-ratio circuits into multilevels enabled precise characterization in sub-terahertz frequency regime. This achievement prompted us to investigate beam-wave interaction through a vacuum-sealed integration with a 15-kV, 85-mA, thermionic, electron gun. Our experimental study demonstrates sub-terahertz, backward-wave amplification driven by an external oscillator. The measured output shows a frequency downshift, as well as power amplification, from beam loading even with low beam perveance. This offers a promising opportunity for the development of terahertz radiation sources, based on silicon technologies.

Experimental observation of sub-terahertz backward-wave amplification in a multi-level microfabricated slow-wave circuit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baik, Chan-Wook, E-mail: cw.baik@samsung.com; Ahn, Ho Young; Kim, Yongsung

2015-11-09

In our earlier paper dealing with dispersion retrieval from ultra-deep, reactive-ion-etched, slow-wave circuits on silicon substrates, it was proposed that splitting high-aspect-ratio circuits into multilevels enabled precise characterization in sub-terahertz frequency regime. This achievement prompted us to investigate beam-wave interaction through a vacuum-sealed integration with a 15-kV, 85-mA, thermionic, electron gun. Our experimental study demonstrates sub-terahertz, backward-wave amplification driven by an external oscillator. The measured output shows a frequency downshift, as well as power amplification, from beam loading even with low beam perveance. This offers a promising opportunity for the development of terahertz radiation sources, based on silicon technologies.

β oscillation during slow wave sleep and rapid eye movement sleep in the electroencephalogram of a transgenic mouse model of Huntington's disease.

PubMed

Jeantet, Yannick; Cayzac, Sebastien; Cho, Yoon H

2013-01-01

To search for early abnormalities in electroencephalogram (EEG) during sleep which may precede motor symptoms in a transgenic mouse model of hereditary neurodegenerative Huntington's disease (HD). In the R6/1 transgenic mouse model of HD, rhythmic brain activity in EEG recordings was monitored longitudinally and across vigilance states through the onset and progression of disease. Mice with chronic electrode implants were recorded monthly over wake-sleep cycles (4 hours), beginning at 9-11 weeks (presymptomatic period) through 6-7 months (symptomatic period). Recording data revealed a unique β rhythm (20-35 Hz), present only in R6/1 transgenic mice, which evolves in close parallel with the disease. In addition, there was an unusual relationship between this β oscillation and vigilance states: while nearly absent during the active waking state, the β oscillation appeared with drowsiness and during slow wave sleep (SWS) and, interestingly, strengthened rather than dissipating when the brain returned to an activated state during rapid eye movement (REM) sleep. In addition to providing a new in vivo biomarker and insight into Huntington's disease pathophysiology, this serendipitous observation opens a window onto the rarely explored neurophysiology of the cortico-basal ganglia circuit during SWS and REM sleep.

Choline acetyltransferase expression during periods of behavioral activity and across natural sleep-wake states in the basal forebrain.

PubMed

Greco, M A; McCarley, R W; Shiromani, P J

1999-01-01

The present study examined whether the expression of the messenger RNA encoding the protein responsible for acetylcholine synthesis is associated with sleep-wakefulness. Choline acetyltransferase messenger RNA levels were analysed using a semi-quantitative assay in which reverse transcription was coupled to complementary DNA amplification using the polymerase chain reaction. To examine the relationship between steady-state messenger RNA and behavioral activity, rats were killed during the day (4.00 p.m.) or night (4.00 a.m.), and tissue from the vertical and horizontal limbs of the diagonal bands of Broca was analysed. Choline acetyltransferase messenger RNA levels were higher during the day than during the night. The second study examined more closely the association between choline acetyltransferase messenger RNA levels and individual bouts of wakefulness, slow-wave sleep or rapid eye movement sleep. Choline acetyltransferase messenger RNA levels were low during wakefulness, intermediate in slow-wave sleep and high during rapid eye movement sleep. In contrast, protein activity, measured at a projection site of cholinergic neurons of the basal forebrain, was higher during wakefulness than during sleep. These findings suggest that choline acetyltransferase protein and messenger RNA levels exhibit an inverse relationship during sleep and wakefulness. The increased messenger RNA expression during sleep is consistent with a restorative function of sleep.

Network properties of interstitial cells of Cajal affect intestinal pacemaker activity and motor patterns, according to a mathematical model of weakly coupled oscillators.

PubMed

Wei, Ruihan; Parsons, Sean P; Huizinga, Jan D

2017-03-01

What is the central question of this study? What are the effects of interstitial cells of Cajal (ICC) network perturbations on intestinal pacemaker activity and motor patterns? What is the main finding and its importance? Two-dimensional modelling of the ICC pacemaker activity according to a phase model of weakly coupled oscillators showed that network properties (coupling strength between oscillators, frequency gradient and frequency noise) strongly influence pacemaker network activity and subsequent motor patterns. The model explains motor patterns observed in physiological conditions and provides predictions and testable hypotheses for effects of ICC loss and frequency modulation on the motor patterns. Interstitial cells of Cajal (ICC) are the pacemaker cells of gut motility and are associated with motility disorders. Interstitial cells of Cajal form a network, but the contributions of its network properties to gut physiology and dysfunction are poorly understood. We modelled an ICC network as a two-dimensional network of weakly coupled oscillators with a frequency gradient and showed changes over time in video and graphical formats. Model parameters were obtained from slow-wave-driven contraction patterns in the mouse intestine and pacemaker slow-wave activities from the cat intestine. Marked changes in propagating oscillation patterns (including changes from propagation to non-propagating) were observed by changing network parameters (coupling strength between oscillators, the frequency gradient and frequency noise), which affected synchronization, propagation velocity and occurrence of dislocations (termination of an oscillation). Complete uncoupling of a circumferential ring of oscillators caused the proximal and distal section to desynchronize, but complete synchronization was maintained with only a single oscillator connecting the sections with high enough coupling. The network of oscillators could withstand loss; even with 40% of oscillators lost randomly within the network, significant synchronization and anterograde propagation remained. A local increase in pacemaker frequency diminished anterograde propagation; the effects were strongly dependent on location, frequency gradient and coupling strength. In summary, the model puts forth the hypothesis that fundamental changes in oscillation patterns (ICC slow-wave activity or circular muscle contractions) can occur through physiological modulation of network properties. Strong evidence is provided to accept the ICC network as a system of coupled oscillators. © 2016 The Authors. Experimental Physiology © 2016 The Physiological Society.

Electroencephalograph (EEG) study on self-contemplating image formation

NASA Astrophysics Data System (ADS)

Meng, Qinglei; Hong, Elliot; Choa, Fow-Sen

2016-05-01

Electroencephalography (EEG) is one of the most widely used electrophysiological monitoring methods and plays a significant role in studies of human brain electrical activities. Default mode network (DMN), is a functional connection of brain regions that are activated while subjects are not in task positive state or not focused on the outside world. In this study, EEG was used for human brain signals recording while all subjects were asked to sit down quietly on a chair with eyes closed and thinking about some parts of their own body, such as left and right hands, left and right ears, lips, nose, and the images of faces that they were familiar with as well as doing some simple mathematical calculation. The time is marker when the image is formed in the subject's mind. By analyzing brain activity maps 300ms right before the time marked instant for each of the 4 wave bands, Delta, Theta, Alpha and Beta waves. We found that for most EEG datasets during this 300ms, Delta wave activity would mostly locate at the frontal lobe or the visual cortex, and the change and movement of activities are slow. Theta wave activity tended to rotate along the edge of cortex either clockwise or counterclockwise. Beta wave behaved like inquiry types of oscillations between any two regions spread over the cortex. Alpha wave activity looks like a mix of the Theta and Beta activities but more close to Theta activity. From the observation we feel that Beta and high Alpha are playing utility role for information inquiry. Theta and low Alpha are likely playing the role of binding and imagination formation in DMN operations.

"Slowing" Mechanical Waves with a Consumer-Type High-Speed Digital Camera

ERIC Educational Resources Information Center

Ng, Pun-hon; Chan, Kin-lok

2015-01-01

In most secondary physics textbooks, waves are first introduced with examples of mechanical waves because they can be illustrated by drawings and photographs. However, these illustrations are static and cannot reflect the dynamic nature of waves. Although many mechanical waves (e.g. water waves and vibrating strings) can be easily shown using…

Age affects sleep microstructure more than sleep macrostructure.

PubMed

Schwarz, Johanna F A; Åkerstedt, Torbjörn; Lindberg, Eva; Gruber, Georg; Fischer, Håkan; Theorell-Haglöw, Jenny

2017-06-01

It is well known that the quantity and quality of physiological sleep changes across age. However, so far the effect of age on sleep microstructure has been mostly addressed in small samples. The current study examines the effect of age on several measures of sleep macro- and microstructure in 211 women (22-71 years old) of the 'Sleep and Health in Women' study for whom ambulatory polysomnography was registered. Older age was associated with significantly lower fast spindle (effect size f 2  = 0.32) and K-complex density (f 2  = 0.19) during N2 sleep, as well as slow-wave activity (log) in N3 sleep (f 2  = 0.21). Moreover, total sleep time (f 2  = 0.10), N3 sleep (min) (f 2  = 0.10), rapid eye movement sleep (min) (f 2  = 0.11) and sigma (log) (f 2  = 0.05) and slow-wave activity (log) during non-rapid eye movement sleep (f 2  = 0.09) were reduced, and N1 sleep (f 2  = 0.03) was increased in older age. No significant effects of age were observed on slow spindle density, rapid eye movement density and beta power (log) during non-rapid eye movement sleep. In conclusion, effect sizes indicate that traditional sleep stage scoring may underestimate age-related changes in sleep. © 2017 European Sleep Research Society.

Study on W-band sheet-beam traveling-wave tube based on flat-roofed sine waveguide

NASA Astrophysics Data System (ADS)

Fang, Shuanzhu; Xu, Jin; Jiang, Xuebing; Lei, Xia; Wu, Gangxiong; Li, Qian; Ding, Chong; Yu, Xiang; Wang, Wenxiang; Gong, Yubin; Wei, Yanyu

2018-05-01

A W-band sheet electron beam (SEB) traveling-wave tube (TWT) based on flat-roofed sine waveguide slow-wave structure (FRSWG-SWS) is proposed. The sine wave of the metal grating is replaced by a flat-roofed sine wave around the electron beam tunnel. The slow-wave characteristics including the dispersion properties and interaction impedance have been investigated by using the eigenmode solver in the 3-D electromagnetic simulation software Ansoft HFSS. Through calculations, the FRSWG SWS possesses the larger average interaction impedance than the conventional sine waveguide (SWG) SWS in the frequency range of 86-110 GHz. The beam-wave interaction was studied and particle-in-cell simulation results show that the SEB TWT can produce output power over 120 W within the bandwidth ranging from 90 to 100 GHz, and the maximum output power is 226 W at typical frequency 94 GHz, corresponding electron efficiency of 5.89%.

The Effect of Saturation on Shear Wave Anisotropy in a Transversely Isotropic Medium

NASA Astrophysics Data System (ADS)

Li, W.; Pyrak-Nolte, L. J.

2010-12-01

Seismic monitoring of fluid distributions in the subsurface requires an understanding of the effect of fluid saturation on the anisotropic properties of layered media. Austin Chalk is a carbonate rock composed mainly of calcite (99.9%) with fine bedding caused by a weakly-directed fabric. In this paper, we assess the shear-wave anisotropy of Austin Chalk and the effect of saturation on interpreting anisotropy based on shear wave velocity, attenuation and spectral content as a function of saturation. In the laboratory, we performed full shear-waveform measurements on several dry cubic samples of Austin Chalk with dimensions 50mm x 50mm x 50mm. Two shear-wave contact transducers (central Frequency 1 MHz) were use to send and receive signals. Data was collected for three orthogonal orientations of the sample and as a function of shear wave polarization relative to the layers in the sample. For the waves propagated parallel to the layers, both fast and slow shear waves were observed with velocities of 3444 m/s and 3193 m/s, respectively. It was noted that the minimum and maximum shear wave velocities did not occur when the shear wave polarization were perpendicular or parallel to the layering in the sample but occurred at an orientation of ~25 degrees from the normal to the layers. The sample was then vacuum saturated with water for approximately ~15 hours. The same measurements were performed on the saturated sample as those on the dry sample. Both shear wave velocities observed decreased upon water-saturation with corresponding velocities of 3155 m/s and 2939 m/s, respectively. In the dry condition the difference between the fast and slow shear wave velocities was 250 m/s. This difference decreased to 215 m/s after fluid saturation. In both the dry and saturated condition, the shear wave velocity for waves propagated perpendicularly to the layers was independent of polarization and had the same magnitude as that of the slow shear wave. A wavelet analysis was performed to determine changes in the spectral content of the signals upon saturation as well velocity dispersion. We found that (1) low frequency components exhibit a larger difference in time delay between the fast and slow shear waves for the water-saturated condition than for the dry condition; (2) that high frequency components have relatively small differences in time delay between the dry and saturated conditions; and (3) the dominant frequency shifted to lower frequencies for the fast shear wave upon saturation while no change in dominant frequency was observed for the slow shear wave upon saturation. Thus, fluid saturation affects shear velocity as well as the spectral content of the signal. Acknowledgments: The authors wish to acknowledge support of this work by the Geosciences Research Program, Office of Basic Energy Sciences US Department of Energy (DE-FG02-09ER16022), by Exxon Mobil Upstream Research Company and the GeoMathematical Imaging Group at Purdue University.

Atypical clinical course subacute sclerosing panencephalitis presenting as acute Encephalitis

PubMed Central

Komur, Mustafa; Arslankoylu, Ali E; Okuyaz, Cetin; Kuyucu, Necdet

2012-01-01

We report a 14-year-old boy who presented with loss of consciousness and gait instability. The electroencephalogram (EEG) showed generalized slowing with irregular activity and cerebral magnetic imaging revealed asymmetrical nonspecific signals on basal ganglia. His second electroencephalogram revealed periodical generalized high-voltage slow wave complexes which did not disappear with diazepam induction. Subacute sclerosing panencephalitis (SSPE) was considered and the diagnosis was confirmed with the identification of measles antibodies in cerebrospinal fluid. Our findings show that SSPE should be in mind in the differential diagnosis of meningoencephalitis and acute disseminated encephalomyelitis and highlight the significance of EEG in the diagnosis of unidentified cases. PMID:23248691

Observations of apparent superslow wave propagation in solar prominences

NASA Astrophysics Data System (ADS)

Raes, J. O.; Van Doorsselaere, T.; Baes, M.; Wright, A. N.

2017-06-01

Context. Phase mixing of standing continuum Alfvén waves and/or continuum slow waves in atmospheric magnetic structures such as coronal arcades can create the apparent effect of a wave propagating across the magnetic field. Aims: We observe a prominence with SDO/AIA on 2015 March 15 and find the presence of oscillatory motion. We aim to demonstrate that interpreting this motion as a magneto hydrodynamic (MHD) wave is faulty. We also connect the decrease of the apparent velocity over time with the phase mixing process, which depends on the curvature of the magnetic field lines. Methods: By measuring the displacement of the prominence at different heights to calculate the apparent velocity, we show that the propagation slows down over time, in accordance with the theoretical work of Kaneko et al. We also show that this propagation speed drops below what is to be expected for even slow MHD waves for those circumstances. We use a modified Kippenhahn-Schlüter prominence model to calculate the curvature of the magnetic field and fit our observations accordingly. Results: Measuring three of the apparent waves, we get apparent velocities of 14, 8, and 4 km s-1. Fitting a simple model for the magnetic field configuration, we obtain that the filament is located 103 Mm below the magnetic centre. We also obtain that the scale of the magnetic field strength in the vertical direction plays no role in the concept of apparent superslow waves and that the moment of excitation of the waves happened roughly one oscillation period before the end of the eruption that excited the oscillation. Conclusions: Some of the observed phase velocities are lower than expected for slow modes for the circumstances, showing that they rather fit with the concept of apparent superslow propagation. A fit with our magnetic field model allows for inferring the magnetic geometry of the prominence. The movie attached to Fig. 1 is available at http://www.aanda.org

Speed hysteresis and noise shaping of traveling fronts in neural fields: role of local circuitry and nonlocal connectivity

NASA Astrophysics Data System (ADS)

Capone, Cristiano; Mattia, Maurizio

2017-01-01

Neural field models are powerful tools to investigate the richness of spatiotemporal activity patterns like waves and bumps, emerging from the cerebral cortex. Understanding how spontaneous and evoked activity is related to the structure of underlying networks is of central interest to unfold how information is processed by these systems. Here we focus on the interplay between local properties like input-output gain function and recurrent synaptic self-excitation of cortical modules, and nonlocal intermodular synaptic couplings yielding to define a multiscale neural field. In this framework, we work out analytic expressions for the wave speed and the stochastic diffusion of propagating fronts uncovering the existence of an optimal balance between local and nonlocal connectivity which minimizes the fluctuations of the activation front propagation. Incorporating an activity-dependent adaptation of local excitability further highlights the independent role that local and nonlocal connectivity play in modulating the speed of propagation of the activation and silencing wavefronts, respectively. Inhomogeneities in space of local excitability give raise to a novel hysteresis phenomenon such that the speed of waves traveling in opposite directions display different velocities in the same location. Taken together these results provide insights on the multiscale organization of brain slow-waves measured during deep sleep and anesthesia.

Probing slow dynamics of consolidated granular multicomposite materials by diffuse acoustic wave spectroscopy.

PubMed

Tremblay, Nicolas; Larose, Eric; Rossetto, Vincent

2010-03-01

The stiffness of a consolidated granular medium experiences a drop immediately after a moderate mechanical solicitation. Then the stiffness rises back toward its initial value, following a logarithmic time evolution called slow dynamics. In the literature, slow dynamics has been probed by macroscopic quantities averaged over the sample volume, for instance, by the resonant frequency of vibrational eigenmodes. This article presents a different approach based on diffuse acoustic wave spectroscopy, a technique that is directly sensitive to the details of the sample structure. The parameters of the dynamics are found to depend on the damage of the medium. Results confirm that slow dynamics is, at least in part, due to tiny structural rearrangements at the microscopic scale, such as inter-grain contacts.

Broad self-trapped and slow light bands based on negative refraction and interference of magnetic coupled modes.

PubMed

Fang, Yun-Tuan; Ni, Zhi-Yao; Zhu, Na; Zhou, Jun

2016-01-13

We propose a new mechanism to achieve light localization and slow light. Through the study on the coupling of two magnetic surface modes, we find a special convex band that takes on a negative refraction effect. The negative refraction results in an energy flow concellation effect from two degenerated modes on the convex band. The energy flow concellation effect leads to forming of the self-trapped and slow light bands. In the self-trapped band light is localized around the source without reflection wall in the waveguide direction, whereas in the slow light band, light becomes the standing-waves and moving standing-waves at the center and the two sides of the waveguide, respectively.

Novel high-gain, improved-bandwidth, finned-ladder V-band Traveling-Wave Tube slow-wave circuit design

NASA Technical Reports Server (NTRS)

Kory, Carol L.; Wilson, Jeffrey D.

1994-01-01

The V-band frequency range of 59-64 GHz is a region of the millimeter-wave spectrum that has been designated for inter-satellite communications. As a first effort to develop a high-efficiency V-band Traveling-Wave Tube (TWT), variations on a ring-plane slow-wave circuit were computationally investigated to develop an alternative to the more conventional ferruled coupled-cavity circuit. The ring-plane circuit was chosen because of its high interaction impedance, large beam aperture, and excellent thermal dissipation properties. Despite these advantages, however, low bandwidth and high voltage requirements have, until now, prevented its acceptance outside the laboratory. In this paper, the three-dimensional electrodynamic simulation code MAFIA (solution of MAxwell's Equation by the Finite-Integration-Algorithm) is used to investigate methods of increasing the bandwidth and lowering the operating voltage of the ring-plane circuit. Calculations of frequency-phase dispersion, beam on-axis interaction impedance, attenuation and small-signal gain per wavelength were performed for various geometric variations and loading distributions of the ring-plane TWT slow-wave circuit. Based on the results of the variations, a circuit termed the finned-ladder TWT slow-wave circuit was designed and is compared here to the scaled prototype ring-plane and a conventional ferruled coupled-cavity TWT circuit over the V-band frequency range. The simulation results indicate that this circuit has a much higher gain, significantly wider bandwidth, and a much lower voltage requirement than the scaled ring-plane prototype circuit, while retaining its excellent thermal dissipation properties. The finned-ladder circuit has a much larger small-signal gain per wavelength than the ferruled coupled-cavity circuit, but with a moderate sacrifice in bandwidth.

Technology as the Enabler of a New Wave of Active Learning

ERIC Educational Resources Information Center

Rollag, Keith; Billsberry, Jon

2012-01-01

Education has always been slow on the uptake of new technology. Instructors have established time-worn methods of teaching, and the performance nature of the job puts an emphasis on reliability and predictability. The last thing an instructor wants to be doing is fumbling around trying to make something work in front of an audience of 200…

Increased Alpha (8-12 Hz) Activity during Slow Wave Sleep as a Marker for the Transition from Implicit Knowledge to Explicit Insight

ERIC Educational Resources Information Center

Yordanova, Juliana; Kolev, Vasil; Wagner, Ullrich; Born, Jan; Verleger, Rolf

2012-01-01

The number reduction task (NRT) allows us to study the transition from implicit knowledge of hidden task regularities to explicit insight into these regularities. To identify sleep-associated neurophysiological indicators of this restructuring of knowledge representations, we measured frequency-specific power of EEG while participants slept during…

Developmental trajectories of EEG sleep slow wave activity as a marker for motor skill development during adolescence: a pilot study.

PubMed

Lustenberger, Caroline; Mouthon, Anne-Laure; Tesler, Noemi; Kurth, Salome; Ringli, Maya; Buchmann, Andreas; Jenni, Oskar G; Huber, Reto

2017-01-01

Reliable markers for brain maturation are important to identify neural deviations that eventually predict the development of mental illnesses. Recent studies have proposed topographical EEG-derived slow wave activity (SWA) during NREM sleep as a mirror of cortical development. However, studies about the longitudinal stability as well as the relationship with behavioral skills are needed before SWA topography may be considered such a reliable marker. We examined six subjects longitudinally (over 5.1 years) using high-density EEG and a visuomotor learning task. All subjects showed a steady increase of SWA at a frontal electrode and a decrease in central electrodes. Despite these large changes in EEG power, SWA topography was relatively stable within each subject during development indicating individual trait-like characteristics. Moreover, the SWA changes in the central cluster were related to the development of specific visuomotor skills. Taken together with the previous work in this domain, our results suggest that EEG sleep SWA represents a marker for motor skill development and further supports the idea that SWA mirrors cortical development during childhood and adolescence. © 2016 Wiley Periodicals, Inc.

Kin Rejection: Social Signals, Neural Response and Perceived Distress During Social Exclusion

PubMed Central

Sreekrishnan, Anirudh; Herrera, Tania A.; Wu, Jia; Borelli, Jessica L.; White, Lars O.; Rutherford, Helena J. V.; Mayes, Linda C.; Crowley, Michael J.

2014-01-01

Across species, kin bond together to promote survival. We sought to understand the dyadic effect of exclusion by kin (as opposed to non-kin strangers) on brain activity of the mother and her child and their subjective distress. To this end, we probed mother-child relationships with a computerized ball-toss game Cyberball. When excluded by one another, rather than by a stranger, both mothers and children exhibited a significantly pronounced frontal P2. Moreover, upon kin-rejection versus stranger-rejection, both mothers and children showed incremented left frontal positive slow waves for rejection events. Children reported more distress upon exclusion than their own mothers. Similar to past work, relatively augmented negative frontal slow wave activity predicted greater self-reported ostracism distress. This effect, generalized to the P2, was limited to mother or child- rejection by kin, with comparable magnitude of effect across kin identity (mothers vs. children). For both mothers and children, the frontal P2 peak was significantly pronounced for kin-rejection versus stranger rejection. Taken together, our results document the rapid categorization of social signals as kin-relevant and the specificity of early and late neural markers for predicting felt ostracism. PMID:24909389

Optogenetic activation of septal cholinergic neurons suppresses sharp wave ripples and enhances theta oscillations in the hippocampus.

PubMed

Vandecasteele, Marie; Varga, Viktor; Berényi, Antal; Papp, Edit; Barthó, Péter; Venance, Laurent; Freund, Tamás F; Buzsáki, György

2014-09-16

Theta oscillations in the limbic system depend on the integrity of the medial septum. The different populations of medial septal neurons (cholinergic and GABAergic) are assumed to affect different aspects of theta oscillations. Using optogenetic stimulation of cholinergic neurons in ChAT-Cre mice, we investigated their effects on hippocampal local field potentials in both anesthetized and behaving mice. Cholinergic stimulation completely blocked sharp wave ripples and strongly suppressed the power of both slow oscillations (0.5-2 Hz in anesthetized, 0.5-4 Hz in behaving animals) and supratheta (6-10 Hz in anesthetized, 10-25 Hz in behaving animals) bands. The same stimulation robustly increased both the power and coherence of theta oscillations (2-6 Hz) in urethane-anesthetized mice. In behaving mice, cholinergic stimulation was less effective in the theta (4-10 Hz) band yet it also increased the ratio of theta/slow oscillation and theta coherence. The effects on gamma oscillations largely mirrored those of theta. These findings show that medial septal cholinergic activation can both enhance theta rhythm and suppress peri-theta frequency bands, allowing theta oscillations to dominate.

Effect of Helical Slow-Wave Circuit Variations on TWT Cold-Test Characteristics

NASA Technical Reports Server (NTRS)

Kory, Carol L.; Dayton, J. A., Jr.

1998-01-01

Recent advances in the state of the art of computer modeling offer the possibility for the first time to evaluate the effect that slow-wave structure parameter variations, such as manufacturing tolerances, have on the cold-test characteristics of helical traveling-wave tubes (TWT's). This will enable manufacturers to determine the cost effectiveness of controlling the dimensions of the component parts of the TWT, which is almost impossible to do experimentally without building a large number of tubes and controlling several parameters simultaneously. The computer code MAFIA is used in this analysis to determine the effect on dispersion and on-axis interaction impedance of several helical slow-wave circuit parameter variations, including thickness and relative dielectric constant of the support rods, tape width, and height of the metallized films deposited on the dielectric rods. Previous computer analyzes required so many approximations that accurate determinations of the effect of many relevant dimensions on tube performance were practically impossible.

Effect of Helical Slow-Wave Circuit Variations on TWT Cold-Test Characteristics

NASA Technical Reports Server (NTRS)

Kory, Carol L.; Dayton, James A., Jr.

1997-01-01

Recent advances in the state of the art of computer modeling offer the possibility for the first time to evaluate the effect that slow-wave structure parameter variations, such as manufacturing tolerances, have on the cold-test characteristics of helical traveling-wave tubes (TWT's). This will enable manufacturers to determine the cost effectiveness of controlling the dimensions of the component parts of the TWT, which is almost impossible to do experimentally without building a large number of tubes and controlling several parameters simultaneously. The computer code MAFIA is used in this analysis to determine the effect on dispersion and on-axis interaction impedance of several helical slow-wave circuit parameter variations, including thickness and relative dielectric constant of the support rods, tape width, and height of the metallized films deposited on the dielectric rods. Previous computer analyses required so many approximations that accurate determinations of the effect of many relevant dimensions on tube performance were practically impossible.

Effect of Helical Slow-Wave Circuit Variations on TWT Cold-Test Characteristics

NASA Technical Reports Server (NTRS)

Kory, Carol L.; Dayton, James A., Jr.

1998-01-01

Recent advances in the state of the art of computer modeling offer the possibility for the first time to evaluate the effect that slow-wave structure parameter variations, such'as manufacturing tolerances, have on the cold-test characteristics of helical traveling-wave tubes (TWT's). This will enable manufacturers to determine the cost effectiveness of controlling the dimensions of the component parts of the TWT, which is almost impossible to do experimentally without building a large number of tubes and controlling several parameters simultaneously. The computer code MAxwell's equations by the Finite Integration Algorithm (MAFIA) is used in this analysis to determine the effect on dispersion and on-axis interaction impedance of several helical slow-wave circuit parameter variations, including thickness and relative dielectric constant of the support rods, tape width, and height of the metallized films deposited on the dielectric rods. Previous computer analyzes required so many approximations that accurate determinations of the effect of many relevant dimensions on tube performance were practically impossible.

Effects of a facial nerve lesion on responses in forehead microvessels to conjunctival irritation and paced breathing.

PubMed

Drummond, Peter D

2012-08-16

To investigate parasympathetic influences on the forehead microvasculature, blood flow was monitored bilaterally in seven participants with a unilateral facial nerve lesion during conjunctival irritation with Schirmer's strips and while breathing at 0.15 Hz. Blood flow and slow-wave frequency increased on the intact side of the forehead during Schirmer's test but did not change on the denervated side. However, a 0.15 Hz vascular wave strengthened during paced breathing, particularly on the denervated side. These findings indicate that parasympathetic activity in the facial nerve increases forehead blood flow during minor conjunctival irritation, but may interfere with the 0.15 Hz vascular wave. Copyright © 2012 Elsevier B.V. All rights reserved.

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

PubMed Central

Mander, Bryce A.; Marks, Shawn M.; Vogel, Jacob W.; Rao, Vikram; Lu, Brandon; Saletin, Jared M.; Ancoli-Israel, Sonia; Jagust, William J.; Walker, Matthew P.

2015-01-01

Independent evidence associates β-amyloid pathology with both NREM sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated overnight memory consolidation is unknown. Here, we show that β-amyloid burden within medial prefrontal cortex (mPFC) is significantly correlated with the severity of impairment in NREM SWA generation. Moreover, reduced NREM SWA generation was further associated with impaired overnight memory consolidation and impoverished hippocampal-neocortical memory transformation. Furthermore, structural equation models revealed that the association between mPFC β-amyloid pathology and impaired hippocampus-dependent memory consolidation is not direct, but instead, statistically depends on the intermediary factor of diminished NREM SWA. By linking β-amyloid pathology with impaired NREM SWA, these data implicate sleep disruption as a novel mechanistic pathway through which β-amyloid pathology may contribute to hippocampus-dependent cognitive decline in the elderly. PMID:26030850

REFLECTION OF PROPAGATING SLOW MAGNETO-ACOUSTIC WAVES IN HOT CORONAL LOOPS: MULTI-INSTRUMENT OBSERVATIONS AND NUMERICAL MODELING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mandal, Sudip; Banerjee, Dipankar; Pant, Vaibhav

Slow MHD waves are important tools for understanding coronal structures and dynamics. In this paper, we report a number of observations from the X-Ray Telescope (XRT) on board HINODE and Solar Dynamic Observatory /Atmospheric Imaging Assembly (AIA) of reflecting longitudinal waves in hot coronal loops. To our knowledge, this is the first report of this kind as seen from the XRT and simultaneously with the AIA. The wave appears after a micro-flare occurs at one of the footpoints. We estimate the density and temperature of the loop plasma by performing differential emission measure (DEM) analysis on the AIA image sequence.more » The estimated speed of propagation is comparable to or lower than the local sound speed, suggesting it to be a propagating slow wave. The intensity perturbation amplitude, in every case, falls very rapidly as the perturbation moves along the loop and eventually vanishes after one or more reflections. To check the consistency of such reflection signatures with the obtained loop parameters, we perform a 2.5D MHD simulation, which uses the parameters obtained from our observation as inputs, and perform forward modeling to synthesize AIA 94 Å images. Analyzing the synthesized images, we obtain the same properties of the observables as for the real observation. From the analysis we conclude that a footpoint heating can generate a slow wave which then reflects back and forth in the coronal loop before fading. Our analysis of the simulated data shows that the main agent for this damping is anisotropic thermal conduction.« less

Simulation and development of novel slow-wave structures for miniaturized THz-band vacuum-tube devices

NASA Astrophysics Data System (ADS)

Benedik, Andrey I.; Karetnikova, Tatiana A.; Torgashov, Roman A.; Terentyuk, Artem G.; Rozhnev, Andrey G.; Torgashov, Gennadiy V.; Ryskin, Nikita M.

2018-04-01

Microfabricated vacuum-tube millimeter- and THz-band sources are of great interest for numerous applications such as communications, radar, sensors, imaging, etc. Recently, miniaturized sheet-beam traveling-wave tubes for sub-THz and THz operation have attracted a considerable interest. In this paper, we present the results of modeling and development of slow-wave structures (SWS) for medium power (10-100 W) traveling-wave tube (TWT) amplifiers and backwardwave oscillators (BWO) in near-THz frequency band. Different types of SWSs are considered, such as double-vane SWS for TWT with a sheet electron beam, a folded-waveguide SWS, and novel planar SWSs on dielectric substrates.

TeO2 slow surface acoustic wave Bragg cell

NASA Astrophysics Data System (ADS)

Yao, Shi-Kay

1991-08-01

A newly discovered slow acoustic surface wave (SAW) on a (-110) cut TeO2 surface is reported focusing on its properties studied using a PC based numerical method. It is concluded that the slow SAW is rather tolerant to crystal surface orientation errors and has unusually deep penetration of its shear component into the thickness of substrate, about 47 wavelengths for a half amplitude point. The deep shear field is considered to be beneficial for surface acoustooptic interaction with free propagating focused laser beams. Rotation of the substrate about the z-axis makes it possible to adjust a slow SAW velocity with the potential advantage of trading acoustic velocity for less acoustic attenuation. Wider-bandwidth long signal processing time Bragg cells may be feasible utilizing this trade-off. The slow SAW device is characterized by an extremely low power consumption which might be useful for compact portable or avionics signal processing equipment applications.

Shock and Rarefaction Waves in a Heterogeneous Mantle

NASA Astrophysics Data System (ADS)

Jordan, J.; Hesse, M. A.

2012-12-01

We explore the effect of heterogeneities on partial melting and melt migration during active upwelling in the Earth's mantle. We have constructed simple, explicit nonlinear models in one dimension to examine heterogeneity and its dynamic affects on porosity, temperature and the magnesium number in a partially molten, porous medium comprised of olivine. The composition of the melt and solid are defined by a closed, binary phase diagram for a simplified, two-component olivine system. The two-component solid solution is represented by a phase loop where concentrations 0 and 1 to correspond to fayalite and forsterite, respectively. For analysis, we examine an advective system with a Riemann initial condition. Chromatographic tools and theory have primarily been used to track large, rare earth elements as tracers. In our case, we employ these theoretical tools to highlight the importance of the magnesium number, enthalpy and overall heterogeneity in the dynamics of melt migration. We calculate the eigenvectors and eigenvalues in the concentration-enthalpy space in order to glean the characteristics of the waves emerging the Riemann step. Analysis on Riemann problems of this nature shows us that the composition-enthalpy waves can be represented by self-similar solutions. The eigenvalues of the composition-enthalpy system represent the characteristic wave propagation speeds of the compositions and enthalpy through the domain. Furthermore, the corresponding eigenvectors are the directions of variation, or ``pathways," in concentration-enthalpy space that the characteristic waves follow. In the two-component system, the Riemann problem yields two waves connected by an intermediate concentration-enthalpy state determined by the intersections of the integral curves of the eigenvectors emanating from both the initial and boundary states. The first wave, ``slow path," and second wave, ``fast path," follow the aformentioned pathways set by the eigenvectors. The slow path wave has a zero eigenvalue, corresponding to a wave speed of zero, which preserves a residual imprint of the initial condition. Freezing fronts textemdash those that result in a negative change in porositytextemdash feature fast path waves that travel as shocks, whereas the fast path waves of melting fronts travel as spreading, rarefaction waves.

Mechanisms underlying rhythmic locomotion: interactions between activation, tension and body curvature waves

PubMed Central

Chen, Jun; Friesen, W. Otto; Iwasaki, Tetsuya

2012-01-01

SUMMARY Undulatory animal locomotion arises from three closely related propagating waves that sweep rostrocaudally along the body: activation of segmental muscles by motoneurons (MNs), strain of the body wall, and muscle tension induced by activation and strain. Neuromechanical models that predict the relative propagation speeds of neural/muscle activation, muscle tension and body curvature can reveal crucial underlying control features of the central nervous system and the power-generating mechanisms of the muscle. We provide an analytical explanation of the relative speeds of these three waves based on a model of neuromuscular activation and a model of the body–fluid interactions for leech anguilliform-like swimming. First, we deduced the motoneuron spike frequencies that activate the muscle and the resulting muscle tension during swimming in intact leeches from muscle bending moments. Muscle bending moments were derived from our video-recorded kinematic motion data by our body–fluid interaction model. The phase relationships of neural activation and muscle tension in the strain cycle were then calculated. Our study predicts that the MN activation and body curvature waves have roughly the same speed (the ratio of curvature to MN activation speed ≈0.84), whereas the tension wave travels about twice as fast. The high speed of the tension wave resulting from slow MN activation is explained by the multiplicative effects of MN activation and muscle strain on tension development. That is, the product of two slower waves (activation and strain) with appropriate amplitude, bias and phase can generate a tension wave with twice the propagation speed of the factors. Our study predicts that (1) the bending moment required for swimming is achieved by minimal MN spike frequency, rather than by minimal muscle tension; (2) MN activity is greater in the mid-body than in the head and tail regions; (3) inhibitory MNs not only accelerate the muscle relaxation but also reduce the intrinsic tonus tension during one sector of the swim cycle; and (4) movements of the caudal end are passive during swimming. These predictions await verification or rejection through further experiments on swimming animals. PMID:22189764

Mechanisms underlying rhythmic locomotion: interactions between activation, tension and body curvature waves.

PubMed

Chen, Jun; Friesen, W Otto; Iwasaki, Tetsuya

2012-01-15

Undulatory animal locomotion arises from three closely related propagating waves that sweep rostrocaudally along the body: activation of segmental muscles by motoneurons (MNs), strain of the body wall, and muscle tension induced by activation and strain. Neuromechanical models that predict the relative propagation speeds of neural/muscle activation, muscle tension and body curvature can reveal crucial underlying control features of the central nervous system and the power-generating mechanisms of the muscle. We provide an analytical explanation of the relative speeds of these three waves based on a model of neuromuscular activation and a model of the body-fluid interactions for leech anguilliform-like swimming. First, we deduced the motoneuron spike frequencies that activate the muscle and the resulting muscle tension during swimming in intact leeches from muscle bending moments. Muscle bending moments were derived from our video-recorded kinematic motion data by our body-fluid interaction model. The phase relationships of neural activation and muscle tension in the strain cycle were then calculated. Our study predicts that the MN activation and body curvature waves have roughly the same speed (the ratio of curvature to MN activation speed ≈0.84), whereas the tension wave travels about twice as fast. The high speed of the tension wave resulting from slow MN activation is explained by the multiplicative effects of MN activation and muscle strain on tension development. That is, the product of two slower waves (activation and strain) with appropriate amplitude, bias and phase can generate a tension wave with twice the propagation speed of the factors. Our study predicts that (1) the bending moment required for swimming is achieved by minimal MN spike frequency, rather than by minimal muscle tension; (2) MN activity is greater in the mid-body than in the head and tail regions; (3) inhibitory MNs not only accelerate the muscle relaxation but also reduce the intrinsic tonus tension during one sector of the swim cycle; and (4) movements of the caudal end are passive during swimming. These predictions await verification or rejection through further experiments on swimming animals.

Spontaneous and electrically modulated spatiotemporal dynamics of the neocortical slow oscillation and associated local fast activity.

PubMed

Greenberg, Anastasia; Dickson, Clayton T

2013-12-01

The neocortical slow oscillation (SO; ~1Hz) of non-REM sleep and anesthesia reflects synchronized network activity composed of alternating active and silent (ON/OFF) phases at the local network and cellular level. The SO itself shows self-organized spatiotemporal dynamics as it appears to originate at unique foci on each cycle and then propagates across the cortical surface. During sleep, this rhythm is relevant for neuroplastic processes mediating memory consolidation especially since its enhancement by slow, rhythmic electrical fields improves subsequent recall. However, the neurobiological mechanism by which spontaneous or enhanced SO activity might operate on memory traces is unknown. Here we show a series of original results, using cycle to cycle tracking across multiple neocortical sites in urethane anesthetized rats: The spontaneous spatiotemporal dynamics of the SO are complex, showing interfering propagation patterns in the anterior-to-posterior plane. These patterns compete for expression and tend to alternate following phase resets that take place during the silent OFF phase of the SO. Applying sinusoidal electrical field stimulation to the anterior pole of the cerebral cortex progressively entrained local field, gamma, and multi-unit activity at all sites, while disrupting the coordination of endogenous SO activity. Field stimulation also biased propagation in the anterior-to-posterior direction and more notably, enhanced the long-range gamma synchrony between cortical regions. These results are the first to show that changes to slow wave dynamics cause enhancements in high frequency cortico-cortical communication and provide mechanistic clues into how the SO is relevant for sleep-dependent memory consolidation. © 2013.

Numerical Study of Transmission Loss Through a Slow Gas Layer Adjacent to a Plate

NASA Technical Reports Server (NTRS)

Schiller, Noah H.; Beck, Benjamin S.; Slagle, Adam C.

2013-01-01

This paper describes a systematic numerical investigation of the sound transmission loss through a multilayer system consisting of a bagged gas and lightweight panel. The goal of the study is to better understand the effect of the gas on transmission loss and determine whether a gas with a slow speed of sound is beneficial for noise control applications. As part of the study, the density and speed of sound of the gas are varied independently to assess the impact of each on transmission loss. Results show that near grazing incidence the plane wave transmission loss through the multilayer system is more sensitive to the speed of sound than the density of the gas. In addition, it was found that a slow wave speed in the bagged gas provides more low-frequency transmission loss benefit than a fast wave speed. At low angles of incidence, close to the plate normal, the benefit is due to the reduction of the characteristic impedance of the gas. At high angles of incidence, the benefit is attributed to the fact that the incident waves at the air/gas interface are bent towards the surface normal. Since transmission loss is angle dependent, refraction in the slow gas layer results in a significant improvement in the transmission loss at high angles of incidence.

Strain differences in the somnogenic effects of interferon inducers in mice.

PubMed

Toth, L A

1996-12-01

Increased slow-wave sleep accompanies influenza infection in C57BL/6 mice but not BALB/c mice. These strains of mice possess different alleles of the genetic lucus If-1, which codes for high (If-1h; C57BL/6) and low (If-1(1); BALB/c) production of interferon (IFN), a putative sleep-inducing cytokine. To evaluate the contribution of the If-1 gene to differences in murine sleep propensity, sleep patterns were evaluated in mice treated with the IFN inducers polyinosinic:polycytidilic acid (pIC) or Newcastle disease virus (NDV), with influenza virus, or with murine interferon (IFN-alpha) or IFN-alpha/beta. As compared with baseline values, C57BL/6 mice exhibited increased slow-wave sleep after all three challenges, but BALB/c mice did not. Congenic B6.C-H28c mice, which bear the BALB/c allele for low IFN production on the C57BL/6 genetic background, showed enhanced slow-wave sleep after influenza infection but not after NDV. Exogenous IFN did not enhance slow-wave sleep in either C57BL/6 or BALB/c mice. These data suggest that the If-1 allele may influence the somnogenic responsiveness of mice under some conditions but that additional mechanisms may contribute to sleep enhancement during infectious disease.

Quasi-optical theory of relativistic surface-wave oscillators with one-dimensional and two-dimensional periodic planar structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginzburg, N. S.; Zaslavsky, V. Yu.; Institute of Applied Physics of Russian Academy of Sciences, 46 Ulyanov St., Nizhny Novgorod 603950

2013-11-15

Within the framework of a quasi-optical approach, we develop 2D and 3D self-consistent theory of relativistic surface-wave oscillators. Presenting the radiation field as a sum of two counter-propagating wavebeams coupled on a shallow corrugated surface, we describe formation of an evanescent slow wave. Dispersion characteristics of the evanescent wave following from this method are in good compliance with those found from the direct cst simulations. Considering excitation of the slow wave by a sheet electron beam, we simulate linear and nonlinear stages of interaction, which allows us to determine oscillation threshold conditions, electron efficiency, and output coupling. The transition frommore » the model of surface-wave oscillator operating in the π-mode regime to the canonical model of relativistic backward wave oscillator is considered. We also described a modified scheme of planar relativistic surface-wave oscillators exploiting two-dimensional periodic gratings. Additional transverse propagating waves emerging on these gratings synchronize the emission from a wide sheet rectilinear electron beam allowing realization of a Cherenkov millimeter-wave oscillators with subgigawatt output power level.« less

The dynamics of magnetic Rossby waves in spherical dynamo simulations: A signature of strong-field dynamos?

NASA Astrophysics Data System (ADS)

Hori, K.; Teed, R. J.; Jones, C. A.

2018-03-01

We investigate slow magnetic Rossby waves in convection-driven dynamos in rotating spherical shells. Quasi-geostrophic waves riding on a mean zonal flow may account for some of the geomagnetic westward drifts and have the potential to allow the toroidal field strength within the planetary fluid core to be estimated. We extend the work of Hori et al. (2015) to include a wider range of models, and perform a detailed analysis of the results. We find that a predicted dispersion relation matches well with the longitudinal drifts observed in our strong-field dynamos. We discuss the validity of our linear theory, since we also find that the nonlinear Lorentz terms influence the observed waveforms. These wave motions are excited by convective instability, which determines the preferred azimuthal wavenumbers. Studies of linear rotating magnetoconvection have suggested that slow magnetic Rossby modes emerge in the magnetostrophic regime, in which the Lorentz and Coriolis forces are in balance in the vorticity equation. We confirm this to be predominant balance for the slow waves we have detected in nonlinear dynamo systems. We also show that a completely different wave regime emerges if the magnetic field is not present. Finally we report the corresponding radial magnetic field variations observed at the surface of the shell in our simulations and discuss the detectability of these waves in the geomagnetic secular variation.

CHROMOSPHERIC AND CORONAL WAVE GENERATION IN A MAGNETIC FLUX SHEATH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kato, Yoshiaki; Hansteen, Viggo; Gudiksen, Boris

2016-08-10

Using radiation magnetohydrodynamic simulations of the solar atmospheric layers from the upper convection zone to the lower corona, we investigate the self-consistent excitation of slow magneto-acoustic body waves (slow modes) in a magnetic flux concentration. We find that the convective downdrafts in the close surroundings of a two-dimensional flux slab “pump” the plasma inside it in the downward direction. This action produces a downflow inside the flux slab, which encompasses ever higher layers, causing an upwardly propagating rarefaction wave. The slow mode, excited by the adiabatic compression of the downflow near the optical surface, travels along the magnetic field inmore » the upward direction at the tube speed. It develops into a shock wave at chromospheric heights, where it dissipates, lifts the transition region, and produces an offspring in the form of a compressive wave that propagates further into the corona. In the wake of downflows and propagating shock waves, the atmosphere inside the flux slab in the chromosphere and higher tends to oscillate with a period of ν ≈ 4 mHz. We conclude that this process of “magnetic pumping” is a most plausible mechanism for the direct generation of longitudinal chromospheric and coronal compressive waves within magnetic flux concentrations, and it may provide an important heat source in the chromosphere. It may also be responsible for certain types of dynamic fibrils.« less

Electroencephalographic profiles for differentiation of disorders of consciousness

PubMed Central

2013-01-01

Background Electroencephalography (EEG) is best suited for long-term monitoring of brain functions in patients with disorders of consciousness (DOC). Mathematical tools are needed to facilitate efficient interpretation of long-duration sleep-wake EEG recordings. Methods Starting with matching pursuit (MP) decomposition, we automatically detect and parametrize sleep spindles, slow wave activity, K-complexes and alpha, beta and theta waves present in EEG recordings, and automatically construct profiles of their time evolution, relevant to the assessment of residual brain function in patients with DOC. Results Above proposed EEG profiles were computed for 32 patients diagnosed as minimally conscious state (MCS, 20 patients), vegetative state/unresponsive wakefulness syndrome (VS/UWS, 11 patients) and Locked-in Syndrome (LiS, 1 patient). Their interpretation revealed significant correlations between patients’ behavioral diagnosis and: (a) occurrence of sleep EEG patterns including sleep spindles, slow wave activity and light/deep sleep cycles, (b) appearance and variability across time of alpha, beta, and theta rhythms. Discrimination between MCS and VS/UWS based upon prominent features of these profiles classified correctly 87% of cases. Conclusions Proposed EEG profiles offer user-independent, repeatable, comprehensive and continuous representation of relevant EEG characteristics, intended as an aid in differentiation between VS/UWS and MCS states and diagnostic prognosis. To enable further development of this methodology into clinically usable tests, we share user-friendly software for MP decomposition of EEG (http://braintech.pl/svarog) and scripts used for creation of the presented profiles (attached to this article). PMID:24143892

A Ka-band radial relativistic backward wave oscillator with GW-class output power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Jiaxin; Zhang, Xiaoping, E-mail: zhangxiaoping@nudt.edu.cn; Dang, Fangchao

A novel radial relativistic backward wave oscillator with a reflector is proposed and designed to generate GW-level high power microwaves at Ka-band. The segmented radial slow wave structure and the reflector are matched to enhance interaction efficiency. We choose the volume wave TM{sub 01} mode as the working mode due to the volume wave characteristic. The main structural parameters of the novel device are optimized by particle-in-cell simulation. High power microwaves with power of 2 GW and a frequency of 29.4 GHz are generated with 30% efficiency when the electron beam voltage is 383 kV, the beam current is 17 kA, and themore » guiding magnetic field is only 0.6 T. Simultaneously, the highest electric field in the novel Ka-band device is just about 960 kV/cm in second slow wave structure.« less

Temporal lobe deficits in murderers: EEG findings undetected by PET.

PubMed

Gatzke-Kopp, L M; Raine, A; Buchsbaum, M; LaCasse, L

2001-01-01

This study evaluates electroencephalography (EEG) and positron emission tomography (PET) in the same subjects. Fourteen murderers were assessed by using both PET (while they were performing the continuous performance task) and EEG during a resting state. EEG revealed significant increases in slow-wave activity in the temporal, but not frontal, lobe in murderers, in contrast to prior PET findings that showed reduced prefrontal, but not temporal, glucose metabolism. Results suggest that resting EEG shows empirical utility distinct from PET activation findings.

Hedgehog regulation of superficial slow muscle fibres in Xenopus and the evolution of tetrapod trunk myogenesis.

PubMed

Grimaldi, Annalisa; Tettamanti, Gianluca; Martin, Benjamin L; Gaffield, William; Pownall, Mary E; Hughes, Simon M

2004-07-01

In tetrapod phylogeny, the dramatic modifications of the trunk have received less attention than the more obvious evolution of limbs. In somites, several waves of muscle precursors are induced by signals from nearby tissues. In both amniotes and fish, the earliest myogenesis requires secreted signals from the ventral midline carried by Hedgehog (Hh) proteins. To determine if this similarity represents evolutionary homology, we have examined myogenesis in Xenopus laevis, the major species from which insight into vertebrate mesoderm patterning has been derived. Xenopus embryos form two distinct kinds of muscle cells analogous to the superficial slow and medial fast muscle fibres of zebrafish. As in zebrafish, Hh signalling is required for XMyf5 expression and generation of a first wave of early superficial slow muscle fibres in tail somites. Thus, Hh-dependent adaxial myogenesis is the likely ancestral condition of teleosts, amphibia and amniotes. Our evidence suggests that midline-derived cells migrate to the lateral somite surface and generate superficial slow muscle. This cell re-orientation contributes to the apparent rotation of Xenopus somites. Xenopus myogenesis in the trunk differs from that in the tail. In the trunk, the first wave of superficial slow fibres is missing, suggesting that significant adaptation of the ancestral myogenic programme occurred during tetrapod trunk evolution. Although notochord is required for early medial XMyf5 expression, Hh signalling fails to drive these cells to slow myogenesis. Later, both trunk and tail somites develop a second wave of Hh-independent slow fibres. These fibres probably derive from an outer cell layer expressing the myogenic determination genes XMyf5, XMyoD and Pax3 in a pattern reminiscent of amniote dermomyotome. Thus, Xenopus somites have characteristics in common with both fish and amniotes that shed light on the evolution of somite differentiation. We propose a model for the evolutionary adaptation of myogenesis in the transition from fish to tetrapod trunk.

Slow [Na+]i dynamics impacts arrhythmogenesis and spiral wave reentry in cardiac myocyte ionic model.

PubMed

Krogh-Madsen, Trine; Christini, David J

2017-09-01

Accumulation of intracellular Na + is gaining recognition as an important regulator of cardiac myocyte electrophysiology. The intracellular Na + concentration can be an important determinant of the cardiac action potential duration, can modulate the tissue-level conduction of excitation waves, and can alter vulnerability to arrhythmias. Mathematical models of cardiac electrophysiology often incorporate a dynamic intracellular Na + concentration, which changes much more slowly than the remaining variables. We investigated the dependence of several arrhythmogenesis-related factors on [Na + ] i in a mathematical model of the human atrial action potential. In cell simulations, we found that [Na + ] i accumulation stabilizes the action potential duration to variations in several conductances and that the slow dynamics of [Na + ] i impacts bifurcations to pro-arrhythmic afterdepolarizations, causing intermittency between different rhythms. In long-lasting tissue simulations of spiral wave reentry, [Na + ] i becomes spatially heterogeneous with a decreased area around the spiral wave rotation center. This heterogeneous region forms a functional anchor, resulting in diminished meandering of the spiral wave. Our findings suggest that slow, physiological, rate-dependent variations in [Na + ] i may play complex roles in cellular and tissue-level cardiac dynamics.

Slow [Na+]i dynamics impacts arrhythmogenesis and spiral wave reentry in cardiac myocyte ionic model

NASA Astrophysics Data System (ADS)

Krogh-Madsen, Trine; Christini, David J.

2017-09-01

Accumulation of intracellular Na+ is gaining recognition as an important regulator of cardiac myocyte electrophysiology. The intracellular Na+ concentration can be an important determinant of the cardiac action potential duration, can modulate the tissue-level conduction of excitation waves, and can alter vulnerability to arrhythmias. Mathematical models of cardiac electrophysiology often incorporate a dynamic intracellular Na+ concentration, which changes much more slowly than the remaining variables. We investigated the dependence of several arrhythmogenesis-related factors on [Na+]i in a mathematical model of the human atrial action potential. In cell simulations, we found that [Na+]i accumulation stabilizes the action potential duration to variations in several conductances and that the slow dynamics of [Na+]i impacts bifurcations to pro-arrhythmic afterdepolarizations, causing intermittency between different rhythms. In long-lasting tissue simulations of spiral wave reentry, [Na+]i becomes spatially heterogeneous with a decreased area around the spiral wave rotation center. This heterogeneous region forms a functional anchor, resulting in diminished meandering of the spiral wave. Our findings suggest that slow, physiological, rate-dependent variations in [Na+]i may play complex roles in cellular and tissue-level cardiac dynamics.

Iterative Covariance-based Removal of Time-Synchronous Artifacts: Application to Gastrointestinal Electrical Recordings

PubMed Central

Putney, Joy; Hilbert, Douglas; Paskaranandavadivel, Niranchan; Cheng, Leo K.; O'Grady, Greg; Angeli, Timothy R.

2016-01-01

Objective The aim of this study was to develop, validate, and apply a fully automated method for reducing large temporally synchronous artifacts present in electrical recordings made from the gastrointestinal (GI) serosa, which are problematic for properly assessing slow wave dynamics. Such artifacts routinely arise in experimental and clinical settings from motion, switching behavior of medical instruments, or electrode array manipulation. Methods A novel iterative COvaraiance-Based Reduction of Artifacts (COBRA) algorithm sequentially reduced artifact waveforms using an updating across-channel median as a noise template, scaled and subtracted from each channel based on their covariance. Results Application of COBRA substantially increased the signal-to-artifact ratio (12.8±2.5 dB), while minimally attenuating the energy of the underlying source signal by 7.9% on average (-11.1±3.9 dB). Conclusion COBRA was shown to be highly effective for aiding recovery and accurate marking of slow wave events (sensitivity = 0.90±0.04; positive-predictive value = 0.74±0.08) from large segments of in vivo porcine GI electrical mapping data that would otherwise be lost due to a broad range of contaminating artifact waveforms. Significance Strongly reducing artifacts with COBRA ultimately allowed for rapid production of accurate isochronal activation maps detailing the dynamics of slow wave propagation in the porcine intestine. Such mapping studies can help characterize differences between normal and dysrhythmic events, which have been associated with GI abnormalities, such as intestinal ischemia and gastroparesis. The COBRA method may be generally applicable for removing temporally synchronous artifacts in other biosignal processing domains. PMID:26829772

Brain potentials during mental arithmetic: effects of extensive practice and problem difficulty.

PubMed

Pauli, P; Lutzenberger, W; Rau, H; Birbaumer, N; Rickard, T C; Yaroush, R A; Bourne, L E

1994-07-01

Recent behavioral investigations indicate that the processes underlying mental arithmetic change systematically with practice from deliberate, conscious calculation to automatic, direct retrieval of answers from memory [Bourne, L.E.Jr. and Rickard, T.C., Mental calculation: The development of a cognitive skill, Paper presented at the Interamerican Congress of Psychology, San Jose, Costa Rica, 1991: Psychol. Rev., 95 (1988) 492-527]. Results reviewed by Moscovitch and Winocur [In: The handbook of aging and cognition, Erlbaum, Hillsdale, NJ, 1992, pp. 315-372] suggest that consciously controlled processes are more dependent on frontal lobe function than are automatic processes. It is appropriate, therefore to determine whether transitions in the locus of primary brain activity occur with practice on mental calculation. In this experiment, we examine the relationship between characteristics of event-related brain potentials (ERPs) and mental arithmetic. Single-digit mental multiplication problems varying in difficulty (problem size) were used, and subjects were trained on these problems for four sessions. Problem-size and practice effects were reliably found in behavioral measures (RT). The ERP was characterized by a pronounced late positivity after task presentation followed by a slow wave, and a negativity during response indication. These components responded differentially to the practice and problem-size manipulations. Practice mainly affected topography of the amplitude of positivity and offset latency of slow wave, and problem-size mainly offset latency of slow wave and pre-response negativity. Fronto-central positivity diminished from session to session, and the focus of positivity centered finally at centro-parietal regions.(ABSTRACT TRUNCATED AT 250 WORDS)

Mapping slow waves and spikes in chronically instrumented conscious dogs: implantation techniques and recordings.

PubMed

Ver Donck, L; Lammers, W J E P; Moreaux, B; Smets, D; Voeten, J; Vekemans, J; Schuurkes, J A J; Coulie, B

2006-03-01

Myoelectric recordings from the intestines in conscious animals have been limited to a few electrode sites with relatively large inter-electrode distances. The aim of this project was to increase the number of recording sites to allow high-resolution reconstruction of the propagation of myoelectrical signals. Sets of six unipolar electrodes, positioned in a 3x2 array, were constructed. A silver ring close to each set served as the reference electrodes. Inter-electrode distances varied from 4 to 8 mm. Electrode sets, to a maximum of 4, were implanted in various configurations allowing recording from 24 sites simultaneously. Four sets of 6 electrodes each were implanted successfully in 11 female Beagles. Implantation sites evaluated were the upper small intestine (n=10), the lower small intestine (n=4) and the stomach (n=3). The implants remained functional for 7.2 months (median; range 1.4-27.3 months). Recorded signals showed slow waves at regular intervals and spike potentials. In addition, when the sets were positioned close together, it was possible to re-construct the propagation of individual slow waves, to determine their direction of propagation and to calculate their propagation velocity. No signs or symptoms of interference with normal GI-function were observed in the tested animals. With this approach, it is possible to implant 24 extracellular electrodes on the serosal surface of the intestines without interfering with its normal physiology. This approach makes it possible to study the electrical activities of the GI system at high resolution in vivo in the conscious animal.

Dynamic Triggering of Seismic Events and Their Relation to Slow Slip in Interior Alaska

NASA Astrophysics Data System (ADS)

Sims, N. E.; Holtkamp, S. G.

2017-12-01

We conduct a search for dynamically triggered events in the Minto Flats Fault Zone (MFFZ), a left-lateral strike-slip zone expressed as multiple, partially overlapping faults, in central Alaska. We focus on the MFFZ because we have observed slow slip processes (earthquake swarms and Very Low Frequency Earthquakes) and interaction between earthquake swarms and larger main-shock (MS) events in this area before. We utilize the Alaska Earthquake Center catalog to identify potential earthquake swarms and dynamically triggered foreshock and mainshock events along the fault zone. We find 30 swarms occurring in the last two decades, five of which we classify as foreshock (FS) swarms due to their close proximity in both time and space to MS events. Many of the earthquake swarms cluster around 15-20 km depth, which is near the seismic-aseismic transition along this fault zone. Additionally, we observe instances of large teleseismic events such as the M8.6 2012 Sumatra earthquake and M7.4 2012 Guatemala earthquake triggering seismic events within the MFFZ, with the Sumatra earthquake triggering a mainshock event that was preceded by an ongoing earthquake swarm and the Guatemala event triggering earthquake swarms that subsequently transition into a larger mainshock event. In both cases an earthquake swarm transitioned into a mainshock-aftershock event and activity continued for several days after the teleseismic waves had passed, lending some evidence to delayed dynamic triggering of seismic events. We hypothesize that large dynamic transient strain associated with the passage of teleseismic surface waves is triggering slow slip processes near the base of the seismogenic zone. These triggered aseismic transient events result in earthquake swarms, which sometimes lead to the nucleation of larger earthquakes. We utilize network matched filtering to build more robust catalogs of swarm earthquake families in this region to search for additional swarm-like or triggered activity in response to teleseismic surface waves, and to test dynamic triggering hypotheses.

Involvement of Spindles in Memory Consolidation Is Slow Wave Sleep-Specific

ERIC Educational Resources Information Center

Cox, Roy; Hofman, Winni F.; Talamini, Lucia M.

2012-01-01

Both sleep spindles and slow oscillations have been implicated in sleep-dependent memory consolidation. Whereas spindles occur during both light and deep sleep, slow oscillations are restricted to deep sleep, raising the possibility of greater consolidation-related spindle involvement during deep sleep. We assessed declarative memory retention…

Selective neuronal lapses precede human cognitive lapses following sleep deprivation.

PubMed

Nir, Yuval; Andrillon, Thomas; Marmelshtein, Amit; Suthana, Nanthia; Cirelli, Chiara; Tononi, Giulio; Fried, Itzhak

2017-12-01

Sleep deprivation is a major source of morbidity with widespread health effects, including increased risk of hypertension, diabetes, obesity, heart attack, and stroke. Moreover, sleep deprivation brings about vehicle accidents and medical errors and is therefore an urgent topic of investigation. During sleep deprivation, homeostatic and circadian processes interact to build up sleep pressure, which results in slow behavioral performance (cognitive lapses) typically attributed to attentional thalamic and frontoparietal circuits, but the underlying mechanisms remain unclear. Recently, through study of electroencephalograms (EEGs) in humans and local field potentials (LFPs) in nonhuman primates and rodents it was found that, during sleep deprivation, regional 'sleep-like' slow and theta (slow/theta) waves co-occur with impaired behavioral performance during wakefulness. Here we used intracranial electrodes to record single-neuron activities and LFPs in human neurosurgical patients performing a face/nonface categorization psychomotor vigilance task (PVT) over multiple experimental sessions, including a session after full-night sleep deprivation. We find that, just before cognitive lapses, the selective spiking responses of individual neurons in the medial temporal lobe (MTL) are attenuated, delayed, and lengthened. These 'neuronal lapses' are evident on a trial-by-trial basis when comparing the slowest behavioral PVT reaction times to the fastest. Furthermore, during cognitive lapses, LFPs exhibit a relative local increase in slow/theta activity that is correlated with degraded single-neuron responses and with baseline theta activity. Our results show that cognitive lapses involve local state-dependent changes in neuronal activity already present in the MTL.

Neuronal oscillations on an ultra-slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork.

PubMed

Belle, Mino D C; Diekman, Casey O

2018-02-03

Neuronal oscillations of the brain, such as those observed in the cortices and hippocampi of behaving animals and humans, span across wide frequency bands, from slow delta waves (0.1 Hz) to ultra-fast ripples (600 Hz). Here, we focus on ultra-slow neuronal oscillators in the hypothalamic suprachiasmatic nuclei (SCN), the master daily clock that operates on interlocking transcription-translation feedback loops to produce circadian rhythms in clock gene expression with a period of near 24 h (< 0.001 Hz). This intracellular molecular clock interacts with the cell's membrane through poorly understood mechanisms to drive the daily pattern in the electrical excitability of SCN neurons, exhibiting an up-state during the day and a down-state at night. In turn, the membrane activity feeds back to regulate the oscillatory activity of clock gene programs. In this review, we emphasise the circadian processes that drive daily electrical oscillations in SCN neurons, and highlight how mathematical modelling contributes to our increasing understanding of circadian rhythm generation, synchronisation and communication within this hypothalamic region and across other brain circuits. © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

The Role of Sleep in Changing Our Minds: A Psychologist's Discussion of Papers on Memory Reactivation and Consolidation in Sleep

ERIC Educational Resources Information Center

Cartwright, Rosalind D.

2004-01-01

The group of papers on memory reactivation and consolidation during sleep included in this volume represents cutting edge work in both animals and humans. They support that the two types of sleep serve different necessary functions. The role of slow wave sleep (SWS) is reactivation of the hippocampal-neocortical circuits activated during a waking…

Effect of Transport Coefficients on Excitation of Flare-induced Standing Slow-mode Waves in Coronal Loops

NASA Astrophysics Data System (ADS)

Wang, Tongjiang; Ofman, Leon; Sun, Xudong; Solanki, Sami K.; Davila, Joseph M.

2018-06-01

Standing slow-mode waves have been recently observed in flaring loops by the Atmospheric Imaging Assembly of the Solar Dynamics Observatory. By means of the coronal seismology technique, transport coefficients in hot (∼10 MK) plasma were determined by Wang et al., revealing that thermal conductivity is nearly suppressed and compressive viscosity is enhanced by more than an order of magnitude. In this study, we use 1D nonlinear MHD simulations to validate the predicted results from the linear theory and investigate the standing slow-mode wave excitation mechanism. We first explore the wave trigger based on the magnetic field extrapolation and flare emission features. Using a flow pulse driven at one footpoint, we simulate the wave excitation in two types of loop models: Model 1 with the classical transport coefficients and Model 2 with the seismology-determined transport coefficients. We find that Model 2 can form the standing wave pattern (within about one period) from initial propagating disturbances much faster than Model 1, in better agreement with the observations. Simulations of the harmonic waves and the Fourier decomposition analysis show that the scaling law between damping time (τ) and wave period (P) follows τ ∝ P 2 in Model 2, while τ ∝ P in Model 1. This indicates that the largely enhanced viscosity efficiently increases the dissipation of higher harmonic components, favoring the quick formation of the fundamental standing mode. Our study suggests that observational constraints on the transport coefficients are important in understanding both the wave excitation and damping mechanisms.

Sleep-Related Electrophysiology and Behavior of Tinamous (Eudromia elegans): Tinamous Do Not Sleep Like Ostriches.

PubMed

Tisdale, Ryan K; Vyssotski, Alexei L; Lesku, John A; Rattenborg, Niels C

2017-01-01

The functions of slow wave sleep (SWS) and rapid eye movement (REM) sleep, distinct sleep substates present in both mammals and birds, remain unresolved. One approach to gaining insight into their function is to trace the evolution of these states through examining sleep in as many taxonomic groups as possible. The mammalian and avian clades are each composed of two extant groups, i.e., the monotremes (echidna and platypus) and therian (marsupial and eutherian [or placental]) mammals, and Palaeognaths (cassowaries, emus, kiwi, ostriches, rheas, and tinamous) and Neognaths (all other birds) among birds. Previous electrophysiological studies of monotremes and ostriches have identified a unique "mixed" sleep state combining features of SWS and REM sleep unlike the well-delineated sleep states observed in all therian mammals and Neognath birds. In the platypus this state is characterized by periods of REM sleep-related myoclonic twitching, relaxed skeletal musculature, and rapid eye movements, occurring in conjunction with SWS-related slow waves in the forebrain electroencephalogram (EEG). A similar mixed state was also observed in ostriches; although in addition to occurring during periods with EEG slow waves, reduced muscle tone and rapid eye movements also occurred in conjunction with EEG activation, a pattern typical of REM sleep in Neognath birds. Collectively, these studies suggested that REM sleep occurring exclusively as an integrated state with forebrain activation might have evolved independently in the therian and Neognath lineages. To test this hypothesis, we examined sleep in the elegant crested tinamou (Eudromia elegans), a small Palaeognath bird that more closely resembles Neognath birds in size and their ability to fly. A 24-h period was scored for sleep state based on electrophysiology and behavior. Unlike ostriches, but like all of the Neognath birds examined, all indicators of REM sleep usually occurred in conjunction with forebrain activation in tinamous. The absence of a mixed REM sleep state in tinamous calls into question the idea that this state is primitive among Palaeognath birds and therefore birds in general. © 2017 S. Karger AG, Basel.

Kinetic theory and Vlasov simulation of nonlinear ion-acoustic waves in multi-ion species plasmas.

PubMed

Chapman, T; Berger, R L; Brunner, S; Williams, E A

2013-05-10

The theory of damping and nonlinear frequency shifts from particles resonant with ion-acoustic waves (IAWs) is presented for multi-ion species plasma and compared to driven wave Vlasov simulations. Two distinct IAW modes may be supported in multi-ion species plasmas, broadly classified as fast and slow by their phase velocity relative to the constituent ion thermal velocities. In current fusion-relevant long pulse experiments, the ion to electron temperature ratio, T(i)/T(e), is expected to reach a level such that the least damped and thus more readily driven mode is the slow mode, with both linear and nonlinear properties that are shown to differ significantly from the fast mode. The lighter ion species of the slow mode is found to make no significant contribution to the IAW frequency shift despite typically being the dominant contributor to the Landau damping.

The Origin of Compressible Magnetic Turbulence in the Very Local Interstellar Medium

NASA Astrophysics Data System (ADS)

Zank, G. P.; Du, S.; Hunana, P.

2017-06-01

Voyager 1 observed compressible magnetic turbulence in the very local interstellar medium (VLISM). We show that inner heliosheath (IHS) fast- and slow-mode waves incident on the heliopause (HP) generate VLISM fast-mode waves only that propagate into the VLISM. We suggest that this is the origin of compressible turbulence in the VLISM. We show that fast- and slow-mode waves transmitted across a tangential discontinuity such as the HP are strongly refracted on crossing the HP and subsequently propagate at highly oblique angles to the VLISM magnetic field. Thus, fast-mode waves in the VLISM contribute primarily to the compressible and not the transverse components of the VLISM fluctuating magnetic field variance < δ {\\hat{B}}2> since < δ {\\hat{B}}{fz}2> \

Lower Extremity Muscle Activity During a Women’s Overhand Lacrosse Shot

PubMed Central

Millard, Brianna M.; Mercer, John A.

2014-01-01

The purpose of this study was to describe lower extremity muscle activity during the lacrosse shot. Participants (n=5 females, age 22±2 years, body height 162.6±15.2 cm, body mass 63.7±23.6 kg) were free from injury and had at least one year of lacrosse experience. The lead leg was instrumented with electromyography (EMG) leads to measure muscle activity of the rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA), and medial gastrocnemius (GA). Participants completed five trials of a warm-up speed shot (Slow) and a game speed shot (Fast). Video analysis was used to identify the discrete events defining specific movement phases. Full-wave rectified data were averaged per muscle per phase (Crank Back Minor, Crank Back Major, Stick Acceleration, Stick Deceleration). Average EMG per muscle was analyzed using a 4 (Phase) × 2 (Speed) ANOVA. BF was greater during Fast vs. Slow for all phases (p<0.05), while TA was not influenced by either Phase or Speed (p>0.05). RF and GA were each influenced by the interaction of Phase and Speed (p<0.05) with GA being greater during Fast vs. Slow shots during all phases and RF greater during Crank Back Minor and Major as well as Stick Deceleration (p<0.05) but only tended to be greater during Stick Acceleration (p=0.076) for Fast vs. Slow. The greater muscle activity (BF, RF, GA) during Fast vs. Slow shots may have been related to a faster approach speed and/or need to create a stiff lower extremity to allow for faster upper extremity movements. PMID:25114727

Density Fluctuations in the Solar Wind Driven by Alfvén Wave Parametric Decay

NASA Astrophysics Data System (ADS)

Bowen, Trevor A.; Badman, Samuel; Hellinger, Petr; Bale, Stuart D.

2018-02-01

Measurements and simulations of inertial compressive turbulence in the solar wind are characterized by anti-correlated magnetic fluctuations parallel to the mean field and density structures. This signature has been interpreted as observational evidence for non-propagating pressure balanced structures, kinetic ion-acoustic waves, as well as the MHD slow-mode. Given the high damping rates of parallel propagating compressive fluctuations, their ubiquity in satellite observations is surprising and suggestive of a local driving process. One possible candidate for the generation of compressive fluctuations in the solar wind is the Alfvén wave parametric instability. Here, we test the parametric decay process as a source of compressive waves in the solar wind by comparing the collisionless damping rates of compressive fluctuations with growth rates of the parametric decay instability daughter waves. Our results suggest that generation of compressive waves through parametric decay is overdamped at 1 au, but that the presence of slow-mode-like density fluctuations is correlated with the parametric decay of Alfvén waves.

Equatorial waves in temperature in the altitude range 4 to 70 km

NASA Astrophysics Data System (ADS)

Krishna Murthy, B. V.; Satheesan, K.; Parameswaran, K.; Sasi, M. N.; Ramkumar, Geetha; Bhavanikumar, Y.; Raghunath, K.; Krishniah, M.

2002-04-01

Using altitude profiles of temperature in the range 4 to 70 km derived from Mesosphere-Stratosphere- Troposphere radar and lidar observations at Gadanki (13.5°N, 79.2°E) from 18 January 1999 to 5 March 1999, characteristics of equatorial waves are studied. Two-dimensional Fourier-transform analysis of the temperature profiles is carried out to identify the periodicities and their vertical wave numbers. From the characteristics obtained, equatorial slow Kelvin waves with periodicities 15.7 d, 9.4 d, 7.8 d and 6.7 d are identified in the troposphere and stratosphere regions and among these 7.8 d and 6.7 d periodicities are found to penetrate into the mesosphere. Equatorial waves with smaller periodicities in the range 5.2 d to 3.6 d are also observed. The vertical flux of horizontal momentum (zonal) of the identified slow Kelvin-wave periodicities in the altitude region 4-25 km is estimated. It is found that equatorial waves modulate tropical tropopause temperature and altitude.

Traveling-Wave Tubes

NASA Technical Reports Server (NTRS)

Kory, Carol L.

1998-01-01

The traveling-wave tube (TWT) is a vacuum device invented in the early 1940's used for amplification at microwave frequencies. Amplification is attained by surrendering kinetic energy from an electron beam to a radio frequency (RF) electromagnetic wave. The demand for vacuum devices has been decreased largely by the advent of solid-state devices. However, although solid state devices have replaced vacuum devices in many areas, there are still many applications such as radar, electronic countermeasures and satellite communications, that require operating characteristics such as high power (Watts to Megawatts), high frequency (below 1 GHz to over 100 GHz) and large bandwidth that only vacuum devices can provide. Vacuum devices are also deemed irreplaceable in the music industry where musicians treasure their tube-based amplifiers claiming that the solid-state and digital counterparts could never provide the same "warmth" (3). The term traveling-wave tube includes both fast-wave and slow-wave devices. This article will concentrate on slow-wave devices as the vast majority of TWTs in operation fall into this category.

Associations between prospective symptom changes and slow-wave activity in patients with Internet gaming disorder: A resting-state EEG study.

PubMed

Kim, Yeon Jin; Lee, Jun-Young; Oh, Sohee; Park, Minkyung; Jung, Hee Yeon; Sohn, Bo Kyung; Choi, Sam-Wook; Kim, Dai Jin; Choi, Jung-Seok

2017-02-01

The identification of the predictive factors and biological markers associated with treatment-related changes in the symptoms of Internet gaming disorder (IGD) may provide a better understanding of the pathophysiology underlying this condition. Thus, the present study aimed to identify neurophysiological markers associated with symptom changes in IGD patients and to identify factors that may predict symptom improvements following outpatient treatment with pharmacotherapy. The present study included 20 IGD patients (mean age: 22.71 ± 5.47 years) and 29 healthy control subjects (mean age: 23.97 ± 4.36 years); all IGD patients completed a 6-month outpatient management program that included pharmacotherapy with selective serotonin reuptake inhibitors. Resting-state electroencephalography scans were acquired prior to and after treatment, and the primary treatment outcome was changes in scores on Young's Internet Addiction Test (IAT) from pre- to posttreatment. IGD patients showed increased resting-state electroencephalography activity in the delta and theta bands at baseline, but the increased delta band activity was normalized after 6 months of treatment and was significantly correlated with improvements in IGD symptoms. Additionally, higher absolute theta activity at baseline predicted a greater possibility of improvement in addiction symptoms following treatment, even after adjusting for the effects of depressive or anxiety symptoms. The present findings demonstrated that increased slow-wave activity represented a state neurophysiological marker in IGD patients and suggested that increased theta activity at baseline may be a favorable prognostic marker for this population.

Sleep spindles in humans: insights from intracranial EEG and unit recordings

PubMed Central

Andrillon, Thomas; Nir, Yuval; Staba, Richard J.; Ferrarelli, Fabio; Cirelli, Chiara; Tononi, Giulio; Fried, Itzhak

2012-01-01

Sleep spindles are an electroencephalographic (EEG) hallmark of non-rapid eye movement (NREM) sleep and are believed to mediate many sleep-related functions, from memory consolidation to cortical development. Spindles differ in location, frequency, and association with slow waves, but whether this heterogeneity may reflect different physiological processes and potentially serve different functional roles remains unclear. Here we utilized a unique opportunity to record intracranial depth EEG and single-unit activity in multiple brain regions of neurosurgical patients to better characterize spindle activity in human sleep. We find that spindles occur across multiple neocortical regions, and less frequently also in the parahippocampal gyrus and hippocampus. Most spindles are spatially restricted to specific brain regions. In addition, spindle frequency is topographically organized with a sharp transition around the supplementary motor area between fast (13-15Hz) centroparietal spindles often occurring with slow wave up-states, and slow (9-12Hz) frontal spindles occurring 200ms later on average. Spindle variability across regions may reflect the underlying thalamocortical projections. We also find that during individual spindles, frequency decreases within and between regions. In addition, deeper sleep is associated with a reduction in spindle occurrence and spindle frequency. Frequency changes between regions, during individual spindles, and across sleep may reflect the same phenomenon, the underlying level of thalamocortical hyperpolarization. Finally, during spindles neuronal firing rates are not consistently modulated, although some neurons exhibit phase-locked discharges. Overall, anatomical considerations can account well for regional spindle characteristics, while variable hyperpolarization levels can explain differences in spindle frequency. PMID:22159098

No effect of odor-induced memory reactivation during REM sleep on declarative memory stability

PubMed Central

Cordi, Maren J.; Diekelmann, Susanne; Born, Jan; Rasch, Björn

2014-01-01

Memory reactivations in hippocampal brain areas are critically involved in memory consolidation processes during sleep. In particular, specific firing patterns of hippocampal place cells observed during learning are replayed during subsequent sleep and rest in rodents. In humans, experimentally inducing hippocampal memory reactivations during slow-wave sleep (but not during wakefulness) benefits consolidation and immediately stabilizes declarative memories against future interference. Importantly, spontaneous hippocampal replay activity can also be observed during rapid eye movement (REM) sleep and some authors have suggested that replay during REM sleep is related to processes of memory consolidation. However, the functional role of reactivations during REM sleep for memory stability is still unclear. Here, we reactivated memories during REM sleep and examined its consequences for the stability of declarative memories. After 3 h of early, slow-wave sleep (SWS) rich sleep, 16 healthy young adults learned a 2-D object location task in the presence of a contextual odor. During subsequent REM sleep, participants were either re-exposed to the odor or to an odorless vehicle, in a counterbalanced within subject design. Reactivation was followed by an interference learning task to probe memory stability after awakening. We show that odor-induced memory reactivation during REM sleep does not stabilize memories against future interference. We propose that the beneficial effect of reactivation during sleep on memory stability might be critically linked to processes characterizing SWS including, e.g., slow oscillatory activity, sleep spindles, or low cholinergic tone, which are required for a successful redistribution of memories from medial temporal lobe regions to neocortical long-term stores. PMID:25225474

β Oscillation during Slow Wave Sleep and Rapid Eye Movement Sleep in the Electroencephalogram of a Transgenic Mouse Model of Huntington’s Disease

PubMed Central

Jeantet, Yannick; Cayzac, Sebastien; Cho, Yoon H.

2013-01-01

Study objectives To search for early abnormalities in electroencephalogram (EEG) during sleep which may precede motor symptoms in a transgenic mouse model of hereditary neurodegenerative Huntington’s disease (HD). Design In the R6/1 transgenic mouse model of HD, rhythmic brain activity in EEG recordings was monitored longitudinally and across vigilance states through the onset and progression of disease. Measurements and results Mice with chronic electrode implants were recorded monthly over wake-sleep cycles (4 hours), beginning at 9–11 weeks (presymptomatic period) through 6–7 months (symptomatic period). Recording data revealed a unique β rhythm (20–35 Hz), present only in R6/1 transgenic mice, which evolves in close parallel with the disease. In addition, there was an unusual relationship between this β oscillation and vigilance states: while nearly absent during the active waking state, the β oscillation appeared with drowsiness and during slow wave sleep (SWS) and, interestingly, strengthened rather than dissipating when the brain returned to an activated state during rapid eye movement (REM) sleep. Conclusions In addition to providing a new in vivo biomarker and insight into Huntington's disease pathophysiology, this serendipitous observation opens a window onto the rarely explored neurophysiology of the cortico-basal ganglia circuit during SWS and REM sleep. PMID:24244517

Neuromodulation: acetylcholine and memory consolidation.

PubMed

Hasselmo

1999-09-01

Clinical and experimental evidence suggests that hippocampal damage causes more severe disruption of episodic memories if those memories were encoded in the recent rather than the more distant past. This decrease in sensitivity to damage over time might reflect the formation of multiple traces within the hippocampus itself, or the formation of additional associative links in entorhinal and association cortices. Physiological evidence also supports a two-stage model of the encoding process in which the initial encoding occurs during active waking and deeper consolidation occurs via the formation of additional memory traces during quiet waking or slow-wave sleep. In this article I will describe the changes in cholinergic tone within the hippocampus in different stages of the sleep-wake cycle and will propose that these changes modulate different stages of memory formation. In particular, I will suggest that the high levels of acetylcholine that are present during active waking might set the appropriate dynamics for encoding new information in the hippocampus, by partially suppressing excitatory feedback connections and so facilitating encoding without interference from previously stored information. By contrast, the lower levels of acetylcholine that are present during quiet waking and slow-wave sleep might release this suppression and thereby allow a stronger spread of activity within the hippocampus itself and from the hippocampus to the entorhinal cortex, thus facilitating the process of consolidation of separate memory traces.

Visual experience and subsequent sleep induce sequential plastic changes in putative inhibitory and excitatory cortical neurons

PubMed Central

Aton, Sara J.; Broussard, Christopher; Dumoulin, Michelle; Seibt, Julie; Watson, Adam; Coleman, Tammi; Frank, Marcos G.

2013-01-01

Ocular dominance plasticity in the developing primary visual cortex is initiated by monocular deprivation (MD) and consolidated during subsequent sleep. To clarify how visual experience and sleep affect neuronal activity and plasticity, we continuously recorded extragranular visual cortex fast-spiking (FS) interneurons and putative principal (i.e., excitatory) neurons in freely behaving cats across periods of waking MD and post-MD sleep. Consistent with previous reports in mice, MD induces two related changes in FS interneurons: a response shift in favor of the closed eye and depression of firing. Spike-timing–dependent depression of open-eye–biased principal neuron inputs to FS interneurons may mediate these effects. During post-MD nonrapid eye movement sleep, principal neuron firing increases and becomes more phase-locked to slow wave and spindle oscillations. Ocular dominance (OD) shifts in favor of open-eye stimulation—evident only after post-MD sleep—are proportional to MD-induced changes in FS interneuron activity and to subsequent sleep-associated changes in principal neuron activity. OD shifts are greatest in principal neurons that fire 40–300 ms after neighboring FS interneurons during post-MD slow waves. Based on these data, we propose that MD-induced changes in FS interneurons play an instructive role in ocular dominance plasticity, causing disinhibition among open-eye–biased principal neurons, which drive plasticity throughout the visual cortex during subsequent sleep. PMID:23300282

Terminal Field and Firing Selectivity of Cholecystokinin-Expressing Interneurons in the Hippocampal CA3 Area

PubMed Central

Lasztóczi, Bálint; Tukker, John J.; Somogyi, Peter; Klausberger, Thomas

2015-01-01

Hippocampal oscillations reflect coordinated neuronal activity on many timescales. Distinct types of GABAergic interneuron participate in the coordination of pyramidal cells over different oscillatory cycle phases. In the CA3 area, which generates sharp waves and gamma oscillations, the contribution of identified GABAergic neurons remains to be defined. We have examined the firing of a family of cholecystokinin-expressing interneurons during network oscillations in urethane-anesthetized rats and compared them with firing of CA3 pyramidal cells. The position of the terminals of individual visualized interneurons was highly diverse, selective, and often spatially coaligned with either the entorhinal or the associational inputs to area CA3. The spike timing in relation to theta and gamma oscillations and sharp waves was correlated with the innervated pyramidal cell domain. Basket and dendritic-layer-innervating interneurons receive entorhinal and associational inputs and preferentially fire on the ascending theta phase, when pyramidal cell assemblies emerge. Perforant-path-associated cells, driven by recurrent collaterals of pyramidal cells fire on theta troughs, when established pyramidal cell assemblies are most active. In the CA3 area, slow and fast gamma oscillations occurred on opposite theta oscillation phases. Perforant-path-associated and some COUP-TFII-positive interneurons are strongly coupled to both fast and slow gamma oscillations, but basket and dendritic-layer-innervating cells are weakly coupled to fast gamma oscillations only. During sharp waves, different interneuron types are activated, inhibited, or remain unaffected. We suggest that specialization in pyramidal cell domain and glutamatergic input-specific operations, reflected in the position of GABAergic terminals, is the evolutionary drive underlying the diversity of cholecystokinin-expressing interneurons. PMID:22159120

Electroencephalography as a Tool for Assessment of Brain Ischemic Alterations after Open Heart Operations

PubMed Central

Golukhova, Elena Z.; Polunina, Anna G.; Lefterova, Natalia P.; Begachev, Alexey V.

2011-01-01

Cardiac surgery is commonly associated with brain ischemia. Few studies addressed brain electric activity changes after on-pump operations. Eyes closed EEG was performed in 22 patients (mean age: 45.2 ± 11.2) before and two weeks after valve replacement. Spouses of patients were invited to participate as controls. Generalized increase of beta power most prominent in beta-1 band was an unambiguous pathological sign of postoperative cortex dysfunction, probably, manifesting due to gamma-activity slowing (“beta buzz” symptom). Generalized postoperative increase of delta-1 mean frequency along with increase of slow-wave activity in right posterior region may be hypothesized to be a consequence of intraoperative ischemia as well. At the same time, significant changes of alpha activity were observed in both patient and control groups, and, therefore, may be considered as physiological. Unexpectedly, controls showed prominent increase of electric activity in left temporal region whereas patients were deficient in left hemisphere activity in comparison with controls at postoperative followup. Further research is needed in order to determine the true neurological meaning of the EEG findings after on-pump operations. PMID:21776370

Slow oscillation amplitudes and up-state lengths relate to memory improvement.

PubMed

Heib, Dominik P J; Hoedlmoser, Kerstin; Anderer, Peter; Zeitlhofer, Josef; Gruber, Georg; Klimesch, Wolfgang; Schabus, Manuel

2013-01-01

There is growing evidence of the active involvement of sleep in memory consolidation. Besides hippocampal sharp wave-ripple complexes and sleep spindles, slow oscillations appear to play a key role in the process of sleep-associated memory consolidation. Furthermore, slow oscillation amplitude and spectral power increase during the night after learning declarative and procedural memory tasks. However, it is unresolved whether learning-induced changes specifically alter characteristics of individual slow oscillations, such as the slow oscillation up-state length and amplitude, which are believed to be important for neuronal replay. 24 subjects (12 men) aged between 20 and 30 years participated in a randomized, within-subject, multicenter study. Subjects slept on three occasions for a whole night in the sleep laboratory with full polysomnography. Whereas the first night only served for adaptation purposes, the two remaining nights were preceded by a declarative word-pair task or by a non-learning control task. Slow oscillations were detected in non-rapid eye movement sleep over electrode Fz. Results indicate positive correlations between the length of the up-state as well as the amplitude of both slow oscillation phases and changes in memory performance from pre to post sleep. We speculate that the prolonged slow oscillation up-state length might extend the timeframe for the transfer of initial hippocampal to long-term cortical memory representations, whereas the increase in slow oscillation amplitudes possibly reflects changes in the net synaptic strength of cortical networks.

Mapping the sources of the seismic wave field at Kilauea volcano, Hawaii, using data recorded on multiple seismic Antennas

USGS Publications Warehouse

Almendros, J.; Chouet, B.; Dawson, P.; Huber, Caleb G.

2002-01-01

Seismic antennas constitute a powerful tool for the analysis of complex wave fields. Well-designed antennas can identify and separate components of a complex wave field based on their distinct propagation properties. The combination of several antennas provides the basis for a more complete understanding of volcanic wave fields, including an estimate of the location of each individual wave-field component identified simultaneously by at least two antennas. We used frequency-slowness analyses of data from three antennas to identify and locate the different components contributing to the wave fields recorded at Kilauea volcano, Hawaii, in February 1997. The wave-field components identified are (1) a sustained background volcanic tremor in the form of body waves generated in a shallow hydrothermal system located below the northeastern edge of the Halemaumau pit crater; (2) surface waves generated along the path between this hydrothermal source and the antennas; (3) back-scattered surface wave energy from a shallow reflector located near the southeastern rim of Kilauea caldera; (4) evidence for diffracted wave components originating at the southeastern edge of Halemaumau; and (5) body waves reflecting the activation of a deeper tremor source between 02 hr 00 min and 16 hr 00 min Hawaii Standard Time on 11 February.

Infrasonic induced ground motions

NASA Astrophysics Data System (ADS)

Lin, Ting-Li

On January 28, 2004, the CERI seismic network recorded seismic signals generated by an unknown source. Our conclusion is that the acoustic waves were initiated by an explosive source near the ground surface. The meteorological temperature and effective sound speed profiles suggested existence of an efficient near-surface waveguide that allowed the acoustic disturbance to propagate to large distances. An explosion occurring in an area of forest and farms would have limited the number of eyewitnesses. Resolution of the source might be possible by experiment or by detailed analysis of the ground motion data. A seismo-acoustic array was built to investigate thunder-induced ground motions. Two thunder events with similar N-wave waveforms but different horizontal slownesses are chosen to evaluate the credibility of using thunder as a seismic source. These impulsive acoustic waves excited P and S reverberations in the near surface that depend on both the incident wave horizontal slowness and the velocity structure in the upper 30 meters. Nineteen thunder events were chosen to further investigate the seismo-acoustic coupling. The consistent incident slowness differences between acoustic pressure and ground motions suggest that ground reverberations were first initiated somewhat away from the array. Acoustic and seismic signals were used to generate the time-domain transfer function through the deconvolution technique. Possible non-linear interaction for acoustic propagation into the soil at the surface was observed. The reverse radial initial motions suggest a low Poisson's ratio for the near-surface layer. The acoustic-to-seismic transfer functions show a consistent reverberation series of the Rayleigh wave type, which has a systematic dispersion relation to incident slownesses inferred from the seismic ground velocity. Air-coupled Rayleigh wave dispersion was used to quantitatively constrain the near-surface site structure with constraints afforded by near-surface body wave refraction and Rayleigh wave dispersion data. Theoretical standard high-frequency and air-coupled Rayleigh wave dispersion calculated by the inferred site structure match the observed dispersion curves. Our study suggests that natural or controlled air-borne pressure sources can be used to investigate the near-surface site structures for earthquake shaking hazard studies.

Transient crustal movement in the northern Izu-Bonin arc starting in 2004: A large slow slip event or a slow back-arc rifting event?

NASA Astrophysics Data System (ADS)

Arisa, Deasy; Heki, Kosuke

2016-07-01

The Izu-Bonin arc lies along the convergent boundary where the Pacific Plate subducts beneath the Philippine Sea Plate. Horizontal velocities of continuous Global Navigation Satellite System stations on the Izu Islands move eastward by up to 1 cm/year relative to the stable part of the Philippine Sea Plate suggesting active back-arc rifting behind the northern part of the arc. Here, we report that such eastward movements transiently accelerated in the middle of 2004 resulting in 3 cm extra movements in 3 years. We compare three different mechanisms possibly responsible for this transient movement, i.e. (1) postseismic movement of the 2004 September earthquake sequence off the Kii Peninsula far to the west, (2) a temporary activation of the back-arc rifting to the west dynamically triggered by seismic waves from a nearby earthquake, and (3) a large slow slip event in the Izu-Bonin Trench to the east. By comparing crustal movements in different regions, the first possibility can be shown unlikely. It is difficult to rule out the second possibility, but current evidence support the third possibility, i.e. a large slow slip event with moment magnitude of 7.5 may have occurred there.

EEG in Sarcoidosis Patients Without Neurological Findings.

PubMed

Bilgin Topçuoğlu, Özgür; Kavas, Murat; Öztaş, Selahattin; Arınç, Sibel; Afşar, Gülgün; Saraç, Sema; Midi, İpek

2017-01-01

Sarcoidosis is a multisystem granulomatous disease affecting nervous system in 5% to 10% of patients. Magnetic resonance imaging (MRI) is accepted as the most sensitive method for detecting neurosarcoidosis. However, the most common findings in MRI are the nonspecific white matter lesions, which may be unrelated to sarcoidosis and can occur because of hypertension, diabetes mellitus, smoking, and other inflammatory or infectious disorders, as well. Autopsy studies report more frequent neurological involvement than the ante mortem studies. The aim of this study is to assess electroencephalography (EEG) in sarcoidosis patients without neurological findings in order to display asymptomatic neurological dysfunction. We performed EEG on 30 sarcoidosis patients without diagnosis of neurosarcoidosis or prior neurological comorbidities. Fourteen patients (46.7%) showed intermittant focal and/or generalized slowings while awake and not mentally activated. Seven (50%) of these 14 patients with EEG slowings had nonspecific white matter changes while the other half showed EEG slowings in the absence of MRI changes. We conclude that EEG slowings, when normal variants (psychomotor variant, temporal theta of elderly, frontal theta waves) are eliminated, may be an indicator of dysfunction in brain activity even in the absence of MRI findings. Hence, EEG may contribute toward detecting asymptomatic neurological dysfunction or probable future neurological involvement in sarcoidosis patients. © EEG and Clinical Neuroscience Society (ECNS) 2016.

Equatorial Kelvin waves: A UARS MLS view

NASA Technical Reports Server (NTRS)

Canziani, Pablo O.; Holton, James R.; Fishbein, Evan; Froidevaux, Lucien; Waters, Joe W.

1994-01-01

Data from the Microwave Limb Sounder (MLS) instrument on the Upper Atmosphere Research Satellite (UARS) are used to compare two periods of Kelvin wave activity during different stages of the equatorial quasi-biennial oscillation. The analysis is carried out using an asynoptic mapping technique. A wide bandpass filter is used to isolate the frequency bands where Kelvin waves have been identified in previous studies. Time-height and time-latitude plots of the bandpassed data are used to identify Kelvin wave activity in the temperature and ozone fields. Frequency spectra of temperature and ozone amplitudes are constructed to further analyze the latitudinal and meridional distribution of Kelvin wave activity in zonal wavenumbers 1 and 2. The characteristics identified in these plots agree well with theoretical predictions and previous observations of middle atmosphere Kelvin waves. The time-height and time-latitude plots support the existence of Kelvin waves in discrete frequency bands; the slow, fast, and ultrafast Kelvin modes are all identified in the data. The characteristics of these modes do not vary much despite different mean flow conditions in the two periods examined. For the Kelvin wave-induced perturbations in ozone, the change from a transport-dominated regime below 10 hPa to a photochemically controlled regime above 10 hPa is clearly apparent in the height dependence of the phase difference between temperature and ozone. The ratios of the ozone perturbation amplitude to the temperature perturbation amplitude for the various observed Kelvin wave modes are in agreement with model estimates and LIMS (Limb Infrared Monitor of the Stratosphere) observations in the lower half of the region sampled but appear to be too large in the upper stratosphere and lower mesosphere.

Experimental study on slow flexural waves around the defect modes in a phononic crystal beam using fiber Bragg gratings

NASA Astrophysics Data System (ADS)

Chuang, Kuo-Chih; Zhang, Zhi-Qiang; Wang, Hua-Xin

2016-12-01

This work experimentally studies influences of the point defect modes on the group velocity of flexural waves in a phononic crystal Timoshenko beam. Using the transfer matrix method with a supercell technique, the band structures and the group velocities around the defect modes are theoretically obtained. Particularly, to demonstrate the existence of the localized defect modes inside the band gaps, a high-sensitivity fiber Bragg grating sensing system is set up and the displacement transmittance is measured. Slow propagation of flexural waves via defect coupling in the phononic crystal beam is then experimentally demonstrated with Hanning windowed tone burst excitations.

Crustal shear-wave splitting from local earthquakes in the Hengill triple junction, southwest Iceland

USGS Publications Warehouse

Evans, J.R.; Foulger, G.R.; Julian, B.R.; Miller, A.D.

1996-01-01

The Hengill region in SW Iceland is an unstable ridge-ridge-transform triple junction between an active and a waning segment of the mid-Atlantic spreading center and a transform that is transgressing southward. The triple junction contains active and extinct spreading segments and a widespread geothermal area. We evaluated shear-wave birefringence for locally recorded upper-crustal earthquakes using an array of 30 three-component digital seismographs. Fast-polarization directions, ??, are mostly NE to NNE, subparallel to the spreading axis and probably caused by fissures and microcracks related to spreading. However, there is significant variability in ?? throughout the array. The lag from fast to slow S is not proportional to earthquake depth (ray length), being scattered at all depths. The average wave-speed difference between qS1 and qS2 in the upper 2-5 km of the crust is 2-5%. Our results suggest considerable heterogeneity or strong S scattering.

Arousal from sleep - The physiological and subjective effects of a 15 dB/A/ reduction in aircraft flyover noise

NASA Technical Reports Server (NTRS)

Levere, T. E.; Davis, N.

1977-01-01

The present research was concerned with whether or not a 15 dB(A) reduction in overall noise level would lessen the sleep disturbing properties of jet aircraft flyover noise and, if less disturbing, whether this would be subjectively appreciated by the sleeping individual. The results indicate that a reduction of 15 dB (A) does result in less sleep disruption but only during sleep characterized by fast-wave electroencephalographic activity. During sleep characterized by slow-wave electroencephalographic activity, such a reduction in the sleep-disturbing properties of jet aircraft noise has little effect. Moreover, even when effective during fast-wave sleep, the decreased arousal produced by the lower noise levels is not subjectively appreciated by the individual in terms of his estimate of the quality of his night's sleep. Thus, reducing the overall noise level of jet aircraft flyovers by some 15 dB(A), is, at best, minimally beneficial to sleep.

Nitric oxide signaling pathways involved in the inhibition of spontaneous activity in the guinea pig prostate.

PubMed

Dey, Anupa; Lang, Richard J; Exintaris, Betty

2012-06-01

We investigated nitric oxide mediated inhibition of spontaneous activity recorded in young and aging guinea pig prostates. Conventional intracellular microelectrode and tension recording techniques were used. The nitric oxide donor sodium nitroprusside (10 μM) abolished spontaneous contractions and slow wave activity in 5 young and 5 aging prostates. Upon adding the nitric oxide synthase inhibitor L-NAME (10 μM) the frequency of spontaneous contractile and electrical activity was significantly increased in each age group. This increase was significantly larger in 4 to 8 preparations of younger vs aging prostates (about 40% to 50% vs about 10% to 20%, 2-way ANOVA p<0.01). Other measured parameters, including the duration, amplitude and membrane potential of spontaneous electrical and contractile activity, were not altered from control values. The guanylate cyclase inhibitor ODQ (10 μM) significantly increased the frequency of spontaneous activity by 10% to 30% in 6 young guinea pig prostates (Student paired t test p<0.05). However, it had no effect on aging prostates. The cGMP analogue 8-Br-GMP (1 μM) and the PDE5 inhibitor dipyridamole (1 μM) significantly decreased the frequency of contractile activity by about 70% in 4 to 9 young and older prostates (Student paired t test p<0.05). The decrease in the response to L-NAME in spontaneous contractile and slow wave activity in aging prostate tissue compared to that in young prostates suggests that with age there is a decrease in nitric oxide production. This may further explain the increase in prostatic smooth muscle tone observed in age related prostate specific conditions, such as benign prostatic hyperplasia. Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

On Kinetic Slow Modes, Fluid Slow Modes, and Pressure-balanced Structures in the Solar Wind

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verscharen, Daniel; Chen, Christopher H. K.; Wicks, Robert T., E-mail: daniel.verscharen@unh.edu, E-mail: christopher.chen@imperial.ac.uk, E-mail: r.wicks@ucl.ac.uk

Observations in the solar wind suggest that the compressive component of inertial-range solar-wind turbulence is dominated by slow modes. The low collisionality of the solar wind allows for nonthermal features to survive, which suggests the requirement of a kinetic plasma description. The least-damped kinetic slow mode is associated with the ion-acoustic (IA) wave and a nonpropagating (NP) mode. We derive analytical expressions for the IA-wave dispersion relation in an anisotropic plasma in the framework of gyrokinetics and then compare them to fully kinetic numerical calculations, results from two-fluid theory, and magnetohydrodynamics (MHD). This comparison shows major discrepancies in the predictedmore » wave phase speeds from MHD and kinetic theory at moderate to high β . MHD and kinetic theory also dictate that all plasma normal modes exhibit a unique signature in terms of their polarization. We quantify the relative amplitude of fluctuations in the three lowest particle velocity moments associated with IA and NP modes in the gyrokinetic limit and compare these predictions with MHD results and in situ observations of the solar-wind turbulence. The agreement between the observations of the wave polarization and our MHD predictions is better than the kinetic predictions, which suggests that the plasma behaves more like a fluid in the solar wind than expected.« less

Calculating qP-wave traveltimes in 2-D TTI media by high-order fast sweeping methods with a numerical quartic equation solver

NASA Astrophysics Data System (ADS)

Han, Song; Zhang, Wei; Zhang, Jie

2017-09-01

A fast sweeping method (FSM) determines the first arrival traveltimes of seismic waves by sweeping the velocity model in different directions meanwhile applying a local solver. It is an efficient way to numerically solve Hamilton-Jacobi equations for traveltime calculations. In this study, we develop an improved FSM to calculate the first arrival traveltimes of quasi-P (qP) waves in 2-D tilted transversely isotropic (TTI) media. A local solver utilizes the coupled slowness surface of qP and quasi-SV (qSV) waves to form a quartic equation, and solve it numerically to obtain possible traveltimes of qP-wave. The proposed quartic solver utilizes Fermat's principle to limit the range of the possible solution, then uses the bisection procedure to efficiently determine the real roots. With causality enforced during sweepings, our FSM converges fast in a few iterations, and the exact number depending on the complexity of the velocity model. To improve the accuracy, we employ high-order finite difference schemes and derive the second-order formulae. There is no weak anisotropy assumption, and no approximation is made to the complex slowness surface of qP-wave. In comparison to the traveltimes calculated by a horizontal slowness shooting method, the validity and accuracy of our FSM is demonstrated.

Lamb wave propagation in monocrystalline silicon wafers.

PubMed

Fromme, Paul; Pizzolato, Marco; Robyr, Jean-Luc; Masserey, Bernard

2018-01-01

Monocrystalline silicon wafers are widely used in the photovoltaic industry for solar panels with high conversion efficiency. Guided ultrasonic waves offer the potential to efficiently detect micro-cracks in the thin wafers. Previous studies of ultrasonic wave propagation in silicon focused on effects of material anisotropy on bulk ultrasonic waves, but the dependence of the wave propagation characteristics on the material anisotropy is not well understood for Lamb waves. The phase slowness and beam skewing of the two fundamental Lamb wave modes A 0 and S 0 were investigated. Experimental measurements using contact wedge transducer excitation and laser measurement were conducted. Good agreement was found between the theoretically calculated angular dependency of the phase slowness and measurements for different propagation directions relative to the crystal orientation. Significant wave skew and beam widening was observed experimentally due to the anisotropy, especially for the S 0 mode. Explicit finite element simulations were conducted to visualize and quantify the guided wave beam skew. Good agreement was found for the A 0 mode, but a systematic discrepancy was observed for the S 0 mode. These effects need to be considered for the non-destructive testing of wafers using guided waves.

Axonal transport of class II and III beta-tubulin: evidence that the slow component wave represents the movement of only a small fraction of the tubulin in mature motor axons

PubMed Central

1992-01-01

Pulse-labeling studies demonstrate that tubulin synthesized in the neuron cell body (soma) moves somatofugally within the axon (at a rate of several millimeters per day) as a well-defined wave corresponding to the slow component of axonal transport. A major goal of the present study was to determine what proportion of the tubulin in mature motor axons is transported in this wave. Lumbar motor neurons in 9-wk-old rats were labeled by injecting [35S]methionine into the spinal cord 2 wk after motor axons were injured (axotomized) by crushing the sciatic nerve. Immunoprecipitation with mAbs which recognize either class II or III beta-tubulin were used to analyze the distributions of radioactivity in these isotypes in intact and axotomized motor fibers 5 d after labeling. We found that both isotypes were associated with the slow component wave, and that the leading edge of this wave was enriched in the class III isotype. Axotomy resulted in significant increases in the labeling and transport rates of both isotypes. Immunohistochemical examination of peripheral nerve fibers demonstrated that nearly all of the class II and III beta-tubulin in nerve fibers is located within axons. Although the amounts of radioactivity per millimeter of nerve in class II and III beta-tubulin were significantly greater in axotomized than in control nerves (with increases of +160% and +58%, respectively), immunoassay revealed no differences in the amounts of these isotypes in axotomized and control motor fibers. We consider several explanations for this paradox; these include the possibility that the total tubulin content is relatively insensitive to changes in the amount of tubulin transported in the slow component wave because this wave represents the movement of only a small fraction of the tubulin in these motor fibers. PMID:1383234

Can Neural Activity Propagate by Endogenous Electrical Field?

PubMed Central

Qiu, Chen; Shivacharan, Rajat S.; Zhang, Mingming

2015-01-01

It is widely accepted that synaptic transmissions and gap junctions are the major governing mechanisms for signal traveling in the neural system. Yet, a group of neural waves, either physiological or pathological, share the same speed of ∼0.1 m/s without synaptic transmission or gap junctions, and this speed is not consistent with axonal conduction or ionic diffusion. The only explanation left is an electrical field effect. We tested the hypothesis that endogenous electric fields are sufficient to explain the propagation with in silico and in vitro experiments. Simulation results show that field effects alone can indeed mediate propagation across layers of neurons with speeds of 0.12 ± 0.09 m/s with pathological kinetics, and 0.11 ± 0.03 m/s with physiologic kinetics, both generating weak field amplitudes of ∼2–6 mV/mm. Further, the model predicted that propagation speed values are inversely proportional to the cell-to-cell distances, but do not significantly change with extracellular resistivity, membrane capacitance, or membrane resistance. In vitro recordings in mice hippocampi produced similar speeds (0.10 ± 0.03 m/s) and field amplitudes (2.5–5 mV/mm), and by applying a blocking field, the propagation speed was greatly reduced. Finally, osmolarity experiments confirmed the model's prediction that cell-to-cell distance inversely affects propagation speed. Together, these results show that despite their weak amplitude, electric fields can be solely responsible for spike propagation at ∼0.1 m/s. This phenomenon could be important to explain the slow propagation of epileptic activity and other normal propagations at similar speeds. SIGNIFICANCE STATEMENT Neural activity (waves or spikes) can propagate using well documented mechanisms such as synaptic transmission, gap junctions, or diffusion. However, the purpose of this paper is to provide an explanation for experimental data showing that neural signals can propagate by means other than synaptic transmission, gap junction, or diffusion. The results indicate that electric fields (ephaptic effects) are capable of mediating propagation of self-regenerating neural waves. This novel mechanism coupling cell-by-volume conduction could be involved in other types of propagating neural signals, such as slow-wave sleep, sharp hippocampal waves, theta waves, or seizures. PMID:26631463

Variable outcome for epilepsy after neonatal hypoglycaemia.

PubMed

Fong, Choong Yi; Harvey, A Simon

2014-11-01

To evaluate the electroclinical features of epilepsy secondary to neonatal hypoglycaemia. This was a retrospective study of children who had seizures beyond infancy after neonatal hypoglycaemia treated at The Royal Children's Hospital, Melbourne between 1996 and 2012. Patients with perinatal asphyxia were excluded. Clinical details were obtained from medical records. Digital electroencephalography (EEG) and brain magnetic resonance imaging (MRI) were reviewed. Eleven patients met the inclusion criteria (six males, five females; mean age 10y 5mo, range 4-18y at the time of review). Age at seizure onset ranged from 4 months to 5 years. Seizures were focal occipital in nine and generalized tonic in two patients. MRI showed gliosis with or without cortical atrophy in the occipital lobe with or without parietal lobe in all. Predominant EEG findings were stereotyped occipital sharp-slow discharges in five, polymorphic occipital spike-wave or paroxysmal fast activity in three, and generalized slow spike-wave and fast activity in two. Seizures were infrequent or remitted in six of the nine children with focal occipital seizures, and frequent and refractory in both children with generalized seizures. Despite the common antecedent and bilateral occipital lobe injury, the seizure manifestations and course of epilepsy after neonatal hypoglycaemia were variable, with mild occipital, refractory occipital, and symptomatic generalized epilepsy recognized. © 2014 Mac Keith Press.

Crustal structure and mantle transition zone thickness beneath a hydrothermal vent at the ultra-slow spreading Southwest Indian Ridge (49°39'E): a supplementary study based on passive seismic receiver functions

NASA Astrophysics Data System (ADS)

Ruan, Aiguo; Hu, Hao; Li, Jiabiao; Niu, Xiongwei; Wei, Xiaodong; Zhang, Jie; Wang, Aoxing

2017-06-01

As a supplementary study, we used passive seismic data recorded by one ocean bottom seismometer (OBS) station (49°41.8'E) close to a hydrothermal vent (49°39'E) at the Southwest Indian Ridge to invert the crustal structure and mantle transition zone (MTZ) thickness by P-to-S receiver functions to investigate previous active seismic tomographic crustal models and determine the influence of the deep mantle thermal anomaly on seafloor hydrothermal venting at an ultra-slow spreading ridge. The new passive seismic S-wave model shows that the crust has a low velocity layer (2.6 km/s) from 4.0 to 6.0 km below the sea floor, which is interpreted as partial melting. We suggest that the Moho discontinuity at 9.0 km is the bottom of a layer (2-3 km thick); the Moho (at depth of 6-7 km), defined by active seismic P-wave models, is interpreted as a serpentinized front. The velocity spectrum stacking plot made from passive seismic data shows that the 410 discontinuity is depressed by 15 km, the 660 discontinuity is elevated by 18 km, and a positive thermal anomaly between 182 and 237 K is inferred.

Cortical activity during cued picture naming predicts individual differences in stuttering frequency

PubMed Central

Mock, Jeffrey R.; Foundas, Anne L.; Golob, Edward J.

2016-01-01

Objective Developmental stuttering is characterized by fluent speech punctuated by stuttering events, the frequency of which varies among individuals and contexts. Most stuttering events occur at the beginning of an utterance, suggesting neural dynamics associated with stuttering may be evident during speech preparation. Methods This study used EEG to measure cortical activity during speech preparation in men who stutter, and compared the EEG measures to individual differences in stuttering rate as well as to a fluent control group. Each trial contained a cue followed by an acoustic probe at one of two onset times (early or late), and then a picture. There were two conditions: a speech condition where cues induced speech preparation of the picture’s name and a control condition that minimized speech preparation. Results Across conditions stuttering frequency correlated to cue-related EEG beta power and auditory ERP slow waves from early onset acoustic probes. Conclusions The findings reveal two new cortical markers of stuttering frequency that were present in both conditions, manifest at different times, are elicited by different stimuli (visual cue, auditory probe), and have different EEG responses (beta power, ERP slow wave). Significance The cue-target paradigm evoked brain responses that correlated to pre-experimental stuttering rate. PMID:27472545

Cortical activity during cued picture naming predicts individual differences in stuttering frequency.

PubMed

Mock, Jeffrey R; Foundas, Anne L; Golob, Edward J

2016-09-01

Developmental stuttering is characterized by fluent speech punctuated by stuttering events, the frequency of which varies among individuals and contexts. Most stuttering events occur at the beginning of an utterance, suggesting neural dynamics associated with stuttering may be evident during speech preparation. This study used EEG to measure cortical activity during speech preparation in men who stutter, and compared the EEG measures to individual differences in stuttering rate as well as to a fluent control group. Each trial contained a cue followed by an acoustic probe at one of two onset times (early or late), and then a picture. There were two conditions: a speech condition where cues induced speech preparation of the picture's name and a control condition that minimized speech preparation. Across conditions stuttering frequency correlated to cue-related EEG beta power and auditory ERP slow waves from early onset acoustic probes. The findings reveal two new cortical markers of stuttering frequency that were present in both conditions, manifest at different times, are elicited by different stimuli (visual cue, auditory probe), and have different EEG responses (beta power, ERP slow wave). The cue-target paradigm evoked brain responses that correlated to pre-experimental stuttering rate. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

The temporal structure of behaviour and sleep homeostasis.

PubMed

Vyazovskiy, Vladyslav V; Tobler, Irene

2012-01-01

The amount and architecture of vigilance states are governed by two distinct processes, which occur at different time scales. The first, a slow one, is related to a wake/sleep dependent homeostatic Process S, which occurs on a time scale of hours, and is reflected in the dynamics of NREM sleep EEG slow-wave activity. The second, a fast one, is manifested in a regular alternation of two sleep states--NREM and REM sleep, which occur, in rodents, on a time scale of ~5-10 minutes. Neither the mechanisms underlying the time constants of these two processes--the slow one and the fast one, nor their functional significance are understood. Notably, both processes are primarily apparent during sleep, while their potential manifestation during wakefulness is obscured by ongoing behaviour. Here, we find, in mice provided with running wheels, that the two sleep processes become clearly apparent also during waking at the level of behavior and brain activity. Specifically, the slow process was manifested in the total duration of waking periods starting from dark onset, while the fast process was apparent in a regular occurrence of running bouts during the waking periods. The dynamics of both processes were stable within individual animals, but showed large interindividual variability. Importantly, the two processes were not independent: the periodic structure of waking behaviour (fast process) appeared to be a strong predictor of the capacity to sustain continuous wakefulness (slow process). The data indicate that the temporal organization of vigilance states on both the fast and the slow time scales may arise from a common neurophysiologic mechanism.

Rg-Lg coupling as a Lg-wave excitation mechanism

NASA Astrophysics Data System (ADS)

Ge, Z.; Xie, X.

2003-12-01

Regional phase Lg is predominantly comprised of shear wave energy trapped in the crust. Explosion sources are expected to be less efficient for excitation of Lg phases than earthquakes to the extent that the source can be approximated as isotropic. Shallow explosions generate relatively large surface wave Rg compared to deeper earthquakes, and Rg is readily disrupted by crustal heterogeneity. Rg energy may thus scatter into trapped crustal S-waves near the source region and contribute to low-frequency Lg wave. In this study, a finite-difference modeling plus the slowness analysis are used for investigating the above mentioned Lg-wave excitation mechanism. The method allows us to investigate near source energy partitioning in multiple domains including frequency, slowness and time. The main advantage of this method is that it can be applied at close range, before Lg is actually formed, which allows us to use very fine near source velocity model to simulate the energy partitioning process. We use a layered velocity structure as the background model and add small near source random velocity patches to the model to generate the Rg to Lg coupling. Two types of simulations are conducted, (1) a fixed shallow explosion source vs. randomness at different depths and (2) a fixed shallow randomness vs. explosion sources at different depths. The results show apparent couplings between the Rg and Lg waves at lower frequencies (0.3-1.5 Hz). A shallow source combined with shallow randomness generates the maximum Lg-wave, which is consistent with the Rg energy distribution of a shallow explosion source. The Rg energy and excited Lg energy show a near linear relationship. The numerical simulation and slowness analysis suggest that the Rg to Lg coupling is an effective excitation mechanism for low frequency Lg-waves from a shallow explosion source.

Nonlinear Decay of Alfvén Waves Driven by Interplaying Two- and Three-dimensional Nonlinear Interactions

NASA Astrophysics Data System (ADS)

Zhao, J. S.; Voitenko, Y.; De Keyser, J.; Wu, D. J.

2018-04-01

We study the decay of Alfvén waves in the solar wind, accounting for the joint operation of two-dimensional (2D) scalar and three-dimensional (3D) vector nonlinear interactions between Alfvén and slow waves. These interactions have previously been studied separately in long- and short-wavelength limits where they lead to 2D scalar and 3D vector decays, correspondingly. The joined action of the scalar and vector interactions shifts the transition between 2D and 3D decays to significantly smaller wavenumbers than was predicted by Zhao et al. who compared separate scalar and vector decays. In application to the broadband Alfvén waves in the solar wind, this means that the vector nonlinear coupling dominates in the extended wavenumber range 5 × 10‑4 ≲ ρ i k 0⊥ ≲ 1, where the decay is essentially 3D and nonlocal, generating product Alfvén and slow waves around the ion gyroscale. Here ρ i is the ion gyroradius, and k 0⊥ is the pump Alfvén wavenumber. It appears that, except for the smallest wavenumbers at and below {ρ }i{k}0\\perp ∼ {10}-4 in Channel I, the nonlinear decay of magnetohydrodynamic Alfvén waves propagating from the Sun is nonlocal and cannot generate counter-propagating Alfvén waves with similar scales needed for the turbulent cascade. Evaluation of the nonlinear frequency shift shows that product Alfvén waves can still be approximately described as normal Alfvénic eigenmodes. On the contrary, nonlinearly driven slow waves deviate considerably from normal modes and are therefore difficult to identify on the basis of their phase velocities and/or polarization.

Finite-frequency wave propagation through outer rise fault zones and seismic measurements of upper mantle hydration

USGS Publications Warehouse

Miller, Nathaniel; Lizarralde, Daniel

2016-01-01

Effects of serpentine-filled fault zones on seismic wave propagation in the upper mantle at the outer rise of subduction zones are evaluated using acoustic wave propagation models. Modeled wave speeds depend on azimuth, with slowest speeds in the fault-normal direction. Propagation is fastest along faults, but, for fault widths on the order of the seismic wavelength, apparent wave speeds in this direction depend on frequency. For the 5–12 Hz Pn arrivals used in tomographic studies, joint-parallel wavefronts are slowed by joints. This delay can account for the slowing seen in tomographic images of the outer rise upper mantle. At the Middle America Trench, confining serpentine to fault zones, as opposed to a uniform distribution, reduces estimates of bulk upper mantle hydration from ~3.5 wt % to as low as 0.33 wt % H2O.

Infrasound from thunder: A natural seismic source

NASA Astrophysics Data System (ADS)

Lin, Ting-L.; Langston, Charles A.

2007-07-01

A small array consisting of five three-component short-period surface seismometers, a three-component borehole seismometer, and five infrasound microphones was built to investigate thunder-induced ground motions. Data from two thunder events with similar N-wave waveforms but different horizontal slownesses are chosen as examples of data collected by the array. These impulsive acoustic waves excited P and S reverberations in the near surface that depend on both the incident wave horizontal slowness and the velocity structure in the upper 30 meters at the site. Although the depth of the borehole is relatively shallow compared to a seismic wave wavelength, velocity amplitude in the radial component decays as much as 63 percent with depth but vertical component amplitudes are unaffected consistent with air-coupled Rayleigh wave excitation. Naturally occurring thunder appears to be a useful seismic source to empirically determine site resonance characteristics for hazards assessments.

The Heating of Solar Coronal Loops by Alfvén Wave Turbulence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Ballegooijen, A. A.; Asgari-Targhi, M.; Voss, A.

2017-11-01

In this paper we further develop a model for the heating of coronal loops by Alfvén wave turbulence (AWT). The Alfvén waves are assumed to be launched from a collection of kilogauss flux tubes in the photosphere at the two ends of the loop. Using a three-dimensional magnetohydrodynamic model for an active-region loop, we investigate how the waves from neighboring flux tubes interact in the chromosphere and corona. For a particular combination of model parameters we find that AWT can produce enough heat to maintain a peak temperature of about 2.5 MK, somewhat lower than the temperatures of 3–4 MKmore » observed in the cores of active regions. The heating rates vary strongly in space and time, but the simulated heating events have durations less than 1 minute and are unlikely to reproduce the observed broad differential emission measure distributions of active regions. The simulated spectral line nonthermal widths are predicted to be about 27 km s{sup −1}, which is high compared to the observed values. Therefore, the present AWT model does not satisfy the observational constraints. An alternative “magnetic braiding” model is considered in which the coronal field lines are subject to slow random footpoint motions, but we find that such long-period motions produce much less heating than the shorter-period waves launched within the flux tubes. We discuss several possibilities for resolving the problem of producing sufficiently hot loops in active regions.« less

Therapeutic effects of antimotion sickness medications on the secondary symptoms of motion sickness

NASA Technical Reports Server (NTRS)

Wood, C. D.; Stewart, J. J.; Wood, M. J.; Manno, J. E.; Manno, B. R.

1990-01-01

In addition to nausea and vomiting, motion sickness involves slowing of brain waves, loss of performance, inhibition of gastric motility and the Sopite Syndrome. The therapeutic effects of antimotion sickness drugs on these reactions were evaluated. The subjects were rotated to the M-III end-point of motion sickness. Intramuscular (IM) medications were then administered. Side effects before and after rotation were reported on the Cornell Medical Index. Brain waves were recorded on a Grass Model 6 Electroencephalograph (EEG), and gastric emptying was studied after an oral dose of 1 mCi Technetium 99m DTPA in 10 oz. isotonic saline. An increase in dizziness and drowsiness was reported with placebo after rotation. This was not prevented by IM scopolamine 0.1 mg or ephedrine 25 mg. EEG recordings indicated a slowing of alpha waves with some thea and delta waves from the frontal areas after rotation. IM ephedine and dimenhydrinate counteracted the slowing while 0.3 mg scopolamine had an additive effect. Alterations of performance on the pursuit meter correlated with the brain wave changes. Gastric emptying was restored by IM metoclopramide. Ephedrine IM but not scopolamine is effective for some of the secondary effects of motion sickness after it is established.

A Simple and Accurate Analysis of Conductivity Loss in Millimeter-Wave Helical Slow-Wave Structures

NASA Astrophysics Data System (ADS)

Datta, S. K.; Kumar, Lalit; Basu, B. N.

2009-04-01

Electromagnetic field analysis of a helix slow-wave structure was carried out and a closed form expression was derived for the inductance per unit length of the transmission-line equivalent circuit of the structure, taking into account the actual helix tape dimensions and surface current on the helix over the actual metallic area of the tape. The expression of the inductance per unit length, thus obtained, was used for estimating the increment in the inductance per unit length caused due to penetration of the magnetic flux into the conducting surfaces following Wheeler’s incremental inductance rule, which was subsequently interpreted for the attenuation constant of the propagating structure. The analysis was computationally simple and accurate, and accrues the accuracy of 3D electromagnetic analysis by allowing the use of dispersion characteristics obtainable from any standard electromagnetic modeling. The approach was benchmarked against measurement for two practical structures, and excellent agreement was observed. The analysis was subsequently applied to demonstrate the effects of conductivity on the attenuation constant of a typical broadband millimeter-wave helical slow-wave structure with respect to helix materials and copper plating on the helix, surface finish of the helix, dielectric loading effect and effect of high temperature operation - a comparative study of various such aspects are covered.

Nonlinear dynamical systems effects of homeopathic remedies on multiscale entropy and correlation dimension of slow wave sleep EEG in young adults with histories of coffee-induced insomnia.

PubMed

Bell, Iris R; Howerter, Amy; Jackson, Nicholas; Aickin, Mikel; Bootzin, Richard R; Brooks, Audrey J

2012-07-01

Investigators of homeopathy have proposed that nonlinear dynamical systems (NDS) and complex systems science offer conceptual and analytic tools for evaluating homeopathic remedy effects. Previous animal studies demonstrate that homeopathic medicines alter delta electroencephalographic (EEG) slow wave sleep. The present study extended findings of remedy-related sleep stage alterations in human subjects by testing the feasibility of using two different NDS analytic approaches to assess remedy effects on human slow wave sleep EEG. Subjects (N=54) were young adult male and female college students with a history of coffee-related insomnia who participated in a larger 4-week study of the polysomnographic effects of homeopathic medicines on home-based all-night sleep recordings. Subjects took one bedtime dose of a homeopathic remedy (Coffea cruda or Nux vomica 30c). We computed multiscale entropy (MSE) and the correlation dimension (Mekler-D2) for stages 3 and 4 slow wave sleep EEG sampled in artifact-free 2-min segments during the first two rapid-eye-movement (REM) cycles for remedy and post-remedy nights, controlling for placebo and post-placebo night effects. MSE results indicate significant, remedy-specific directional effects, especially later in the night (REM cycle 2) (CC: remedy night increases and post-remedy night decreases in MSE at multiple sites for both stages 3 and 4 in both REM cycles; NV: remedy night decreases and post-remedy night increases, mainly in stage 3 REM cycle 2 MSE). D2 analyses yielded more sporadic and inconsistent findings. Homeopathic medicines Coffea cruda and Nux vomica in 30c potencies alter short-term nonlinear dynamic parameters of slow wave sleep EEG in healthy young adults. MSE may provide a more sensitive NDS analytic method than D2 for evaluating homeopathic remedy effects on human sleep EEG patterns. Copyright © 2012 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.

Nonlinear Dynamical Systems Effects of Homeopathic Remedies on Multiscale Entropy and Correlation Dimension of Slow Wave Sleep EEG in Young Adults with Histories of Coffee-Induced Insomnia

PubMed Central

Bell, Iris R.; Howerter, Amy; Jackson, Nicholas; Aickin, Mikel; Bootzin, Richard R.; Brooks, Audrey J.

2012-01-01

Background Investigators of homeopathy have proposed that nonlinear dynamical systems (NDS) and complex systems science offer conceptual and analytic tools for evaluating homeopathic remedy effects. Previous animal studies demonstrate that homeopathic medicines alter delta electroencephalographic (EEG) slow wave sleep. The present study extended findings of remedy-related sleep stage alterations in human subjects by testing the feasibility of using two different NDS analytic approaches to assess remedy effects on human slow wave sleep EEG. Methods Subjects (N=54) were young adult male and female college students with a history of coffee-related insomnia who participated in a larger 4-week study of the polysomnographic effects of homeopathic medicines on home-based all-night sleep recordings. Subjects took one bedtime dose of a homeopathic remedy (Coffea cruda or Nux vomica 30c). We computed multiscale entropy (MSE) and the correlation dimension (Mekler-D2) for stage 3 and 4 slow wave sleep EEG sampled in artifact-free 2-minute segments during the first two rapid-eye-movement (REM) cycles for remedy and post-remedy nights, controlling for placebo and post-placebo night effects. Results MSE results indicate significant, remedy-specific directional effects, especially later in the night (REM cycle 2) (CC: remedy night increases and post-remedy night decreases in MSE at multiple sites for both stages 3 and 4 in both REM cycles; NV: remedy night decreases and post-remedy night increases, mainly in stage 3 REM cycle 2 MSE). D2 analyses yielded more sporadic and inconsistent findings. Conclusions Homeopathic medicines Coffea cruda and Nux vomica in 30c potencies alter short-term nonlinear dynamic parameters of slow wave sleep EEG in healthy young adults. MSE may provide a more sensitive NDS analytic method than D2 for evaluating homeopathic remedy effects on human sleep EEG patterns. PMID:22818237

GABA(B) receptors, schizophrenia and sleep dysfunction: a review of the relationship and its potential clinical and therapeutic implications.

PubMed

Kantrowitz, Joshua; Citrome, Leslie; Javitt, Daniel

2009-08-01

Evidence for an intrinsic relationship between sleep, cognition and the symptomatic manifestations of schizophrenia is accumulating. This review presents evidence for the possible utility of GABA(B) receptor agonists for the treatment of subjective and objective sleep abnormalities related to schizophrenia. At the phenotypic level, sleep disturbance occurs in 16-30% of patients with schizophrenia and is related to reduced quality of life and poor coping skills. On the neurophysiological level, studies suggest that sleep deficits reflect a core component of schizophrenia. Specifically, slow-wave sleep deficits, which are inversely correlated with cognition scores, are seen. Moreover, sleep plays an increasingly well documented role in memory consolidation in schizophrenia. Correlations of slow-wave sleep deficits with impaired reaction time and declarative memory have also been reported. Thus, both behavioural insomnia and sleep architecture are critical therapeutic targets in patients with schizophrenia. However, long-term treatment with antipsychotics often results in residual sleep dysfunction and does not improve slow-wave sleep, and adjunctive GABA(A) receptor modulators, such as benzodiazepines and zolpidem, can impair sleep architecture and cognition in schizophrenia. GABA(B) receptor agonists have therapeutic potential in schizophrenia. These agents have minimal effect on rapid eye movement sleep while increasing slow-wave sleep. Preclinical associations with increased expression of genes related to slow-wave sleep production and circadian rhythm function have also been reported. GABA(B) receptor deficits result in a sustained hyperdopaminergic state and can be reversed by a GABA(B) receptor agonist. Genetic, postmortem and electrophysiological studies also associate GABA(B) receptors with schizophrenia. While studies thus far have not shown significant effects, prior focus on the use of GABA(B) receptor agonists has been on the positive symptoms of schizophrenia, with minimal investigation of GABA(B) receptor agonists such as baclofen or gamma-hydroxybutyric acid and their effects on sleep architecture, cognition and negative symptoms in patients with schizophrenia. Further study is needed.

[Change of character of intersystemic interactions in newborn rat pups under conditions of a decrease of central influences (urethane anesthesia)].

PubMed

Kuznetsov, S V; Sizonov, V A; Dmitrieva, L E

2014-01-01

On newborn rat pups, for the first day after birth, there was studied the character of mutual influences between the slow-wave rhythmical components of the cardiac, respiratory, and motor activities reflecting interactions between the main functional systems of the developing organism. The study was carried out in norm and after pharmacological depression of the spontaneous periodical motor activity (SPMA) performed by narcotization of rat pups with urethane at low (0.5 g/kg, i/p) and maximal (1 g/kg, i/p) doses. Based on the complex of our obtained data, it is possible to conclude that after birth in rat pups the intersystemic interactions are realized mainly by the slow-wave oscillations of the near- and manyminute diapason. The correlational interactions mediated by rhythms of the decasecond diapason do not play essential role in integrative processes. Injection to the animals of urethane producing selective suppression of reaction of consciousness, but not affecting activating influences of reticular formation on cerebral cortex does not cause marked changes of autonomous parameters, but modulates structure and expression of spontaneous periodical motor activity. There occurs an essential decrease of mutual influences between motor and cardiovascular systems. In the case of preservation of motor activity bursts, a tendency for enhancement of correlational relations between the modulating rhythms of motor and somatomotor systems is observed. The cardiorespiratory interactions, more pronounced in intact rat pups in the near- and many-minute modulation diapason, under conditions of urethane, somewhat decrease, whereas the rhythmical components of the decasecond diapason--are weakly enhanced.

A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells.

PubMed

Ford, Kevin J; Arroyo, David A; Kay, Jeremy N; Lloyd, Eric E; Bryan, Robert M; Sanes, Joshua R; Feller, Marla B

2013-05-01

Slow afterhyperpolarizations (sAHPs) play an important role in establishing the firing pattern of neurons that in turn influence network activity. sAHPs are mediated by calcium-activated potassium channels. However, the molecular identity of these channels and the mechanism linking calcium entry to their activation are still unknown. Here we present several lines of evidence suggesting that the sAHPs in developing starburst amacrine cells (SACs) are mediated by two-pore potassium channels. First, we use whole cell and perforated patch voltage clamp recordings to characterize the sAHP conductance under different pharmacological conditions. We find that this conductance was calcium dependent, reversed at EK, blocked by barium, insensitive to apamin and TEA, and activated by arachidonic acid. In addition, pharmacological inhibition of calcium-activated phosphodiesterase reduced the sAHP. Second, we performed gene profiling on isolated SACs and found that they showed strong preferential expression of the two-pore channel gene kcnk2 that encodes TREK1. Third, we demonstrated that TREK1 knockout animals exhibited an altered frequency of retinal waves, a frequency that is set by the sAHPs in SACs. With these results, we propose a model in which depolarization-induced decreases in cAMP lead to disinhibition of the two-pore potassium channels and in which the kinetics of this biochemical pathway dictate the slow activation and deactivation of the sAHP conductance. Our model offers a novel pathway for the activation of a conductance that is physiologically important.

Evaluating the features of the brain waves to quantify ADHD improvement by neurofeedback.

PubMed

Dehghanpour, Peyman; Einalou, Zahra

2017-10-23

Attention-deficit/hyperactivity disorder (ADHD), as one of the most common neurological disorders in children and adolescents, is characterized by decentralization, slow learning, distraction and hyperactivity. Studies have shown that in addition to medication, neurofeedback training can also be used to partially control the brain activity of these patients. In this study, using the brain signals processing before and after the treatment in 10 children treated by neurofeedback, the changes were evaluated by non-parametric statistical analysis and impact of neurofeedback on brain frequency bands was investigated. Finally, the results were compared with the protocols introduced in this paper and before researches. The results of Kruskal-Wallis test showed an approximately significant increase in the relative power of gamma and an approximately significant reduction in the ratio of relative power of alpha/beta. It represents the emotional response, elicited by the successful learning and diminished ratio of slow learning to active learning respectively.

Atrioventricular block, ECG tracing (image)

MedlinePlus

... an abnormal rhythm (arrhythmia) called an atrioventricular (AV) block. P waves show that the top of the ... wave (and heart contraction), there is an atrioventricular block, and a very slow pulse (bradycardia).

Theoretical, Experimental, and Computational Evaluation of Several Vane-Type Slow-Wave Structures

NASA Technical Reports Server (NTRS)

Wallett, Thomas M.; Qureshi, A. Haq

1994-01-01

Several types of periodic vane slow-wave structures were fabricated. The dispersion characteristics were found by theoretical analysis, experimental testing, and computer simulation using the MAFIA code. Computer-generated characteristics agreed to approximately within 2 percent of the experimental characteristics for all structures. The theoretical characteristics, however, deviated increasingly as the width to height ratio became smaller. Interaction impedances were also computed based on the experimental and computer-generated resonance frequency shifts due to the introduction of a perturbing dielectric rod.

A Smart Microwave Vacuum Electron Device (MVED) Using Field Emitters

DTIC Science & Technology

2012-01-31

operation of the device. By using a larger retardation value, the slow wave phase velocity is decreased allowing a lower E/B drift velocity. By reducing...the drift velocity the device is able to run at a lower cathode potential reducing the risk of high voltage arcing. This new slow wave circuit will...sole electrode above the cathode by using a thin dielectric layer ( mylar ) on top of the cathode and placing the sole electrode on the dielectric

Vomiting and gastric electrical dysrhythmia in dogs.

PubMed

Ueno, T; Chen, J D Z

2004-04-01

The correlation between gastric myoelectrical activity (GMA) and gastrointestinal symptoms such as nausea and vomiting is poorly understood. The aim of this study was to assess the association of GMA with vomiting induced by retrograde gastric electrical stimulation or duodenal balloon distention. Ten dogs were involved in this study. Vomiting was induced by retrograde gastric electrical stimulation in 6 dogs and by duodenal balloon distention in 4 dogs. Computerized spectral analysis and visual analysis were applied to detect the GMA change during various periods before and after vomiting. Gastric dysrhythmia preceded vomiting but was of brief duration. The major pattern of dysrhythmia immediately before vomiting was tachyarrhythmia and gastric slow wave was completely uncoupled before vomiting. Gastric dysrhythmia and slow wave uncoupling were also noticed immediately after vomiting but the dogs recovered quickly. The major pattern of dysrhythmia after vomiting was arrhythmia. GMA was normal during the periods other than 5 min before and during vomiting and 5 min after vomiting. Gastric dysrhythmia seems to be the cause of vomiting induced by retrograde gastric electrical stimulation or duodenal balloon distention. It is brief and characterized with tachyarrhythmia and uncoupling.

An electrical description of the generation of slow waves in the antrum of the guinea-pig

PubMed Central

Edwards, FR; Hirst, GDS

2005-01-01

This paper provides an electrical description of the generation of slow waves in the guinea-pig gastric antrum. A short segment of a circular smooth muscle bundle with an attached network of myenteric interstitial cells of Cajal (ICC-MY) and longitudinal muscle sheet was modelled as three electrical compartments with resistive connexions between the ICC-MY compartment and each of the smooth muscle compartments. The circular smooth muscle layer contains a proportion of intramuscular interstitial cells of Cajal (ICC-IM), responsible for the regenerative component of the slow wave. Hence the equivalent cell representing the circular muscle layer incorporated a mechanism, modelled as a two stage reaction, which produces an intracellular messenger. The first stage of the reaction is proposed to be activated in a voltage-dependent manner as described by Hodgkin and Huxley. A similar mechanism was incorporated into the equivalent cell describing the ICC-MY network. Spontaneous discrete transient depolarizations, termed unitary potentials, are detected in records taken from either bundles of circular smooth muscle containing ICC-IM or from ICC-MY. In the simulation the mean rate of discharge of unitary potentials was allowed to vary with the concentration of messenger according to a conventional dose–effect relationship. Such a mechanism, which describes regenerative potentials generated by the circular muscle layer, also simulated the plateau component of the pacemaker potential in the ICC-MY network. A voltage-sensitive membrane conductance was included in the ICC-MY compartment; this was used to describe the primary component of the pacemaker potential. The model generates a range of membrane potential changes with properties similar to those generated by the three cell types present in the intact tissue. PMID:15613372

Prolonged treatment with transcutaneous electrical nerve stimulation (TENS) modulates neuro-gastric motility and plasma levels of vasoactive intestinal peptide (VIP), motilin and interleukin-6 (IL-6) in systemic sclerosis.

PubMed

McNearney, Terry A; Sallam, Hanaa S; Hunnicutt, Sonya E; Doshi, Dipti; Chen, Jiande D Z

2013-01-01

We assessed the effects of transcutaneous electrical nerve stimulation (TENS) on neurogastric functioning in scleroderma patients. Seventeen SSc patients underwent 30 min TENS treatment >10Hz at GI acupuncture points PC6 and ST36, once (acute TENS) and then after two weeks of TENS sessions for 30 min twice daily (prolonged TENS). Data collected at Visits 1 and 2 included gastric myoelectrical activity (GMA) by surface electrogastrography (EGG), heart rate variability (HRV) by surface electrocardiography (EKG), GI specific symptoms and health related SF-36 questionnaires. Plasma VIP, motilin and IL-6 levels were determined. Statistical analyses were performed by Student's t-test, Spearman Rank and p-values <0.05 were considered significant. 1. Only after prolonged TENS, the percentages of normal slow waves and average slow wave coupling (especially channels 1, 2 reflecting gastric pacemaker and corpus regions) were significantly increased; 2. the percentage of normal slow waves was significantly correlated to sympathovagal balance; 3. Mean plasma VIP and motilin levels were significantly decreased after acute TENS, (vs. baseline), generally maintained in the prolonged TENS intervals. Compared to baseline, mean plasma IL-6 levels were significantly increased after acute TENS, but significantly decreased after prolonged TENS. 4. After prolonged TENS, the frequency of awakening due to abdominal pain and abdominal bloating were significantly and modestly decreased, respectively. In SSc patients, two weeks of daily TENS improved patient GMA scores, lowered plasma VIP, motilin and IL-6 levels and improved association between GMA and sympathovagal balance. This supports the therapeutic potential of prolonged TENS to enhance gastric myoelectrical functioning in SSc.

ERP Subsequent Memory Effects Differ between Inter-Item and Unitization Encoding Tasks

PubMed Central

Kamp, Siri-Maria; Bader, Regine; Mecklinger, Axel

2017-01-01

The “subsequent memory paradigm” is an analysis tool to identify brain activity elicited during episodic encoding that is associated with successful subsequent retrieval. Two commonly observed event-related potential “subsequent memory effects” (SMEs) are the parietal SME in the P300 time window and the frontal slow wave SME, but to date a clear characterization of the circumstances under which each SME is observed is missing. To test the hypothesis that the parietal SME occurs when aspects of an experience are unitized into a single item representation, while inter-item associative encoding is reflected in the frontal slow wave effect, participants were assigned to one of two conditions that emphasized one of the encoding types under otherwise matched study phases of a recognition memory experiment. Word pairs were presented either in the context of a definition that allowed to combine the word pairs into a new concept (unitization or item encoding) or together with a sentence frame (inter-item encoding). Performance on the recognition test did not differ between the groups. The parietal SME was only found in the definition group, supporting the idea that this SME occurs when the components of an association are integrated in a unitized item representation. An early prefrontal negativity also exhibited an SME only in this group, suggesting that the formation of novel units occurs through interactions of multiple brain areas. The frontal slow wave SME was pronounced in both groups and may thus reflect processes generally involved in encoding of associations. Our results provide evidence for a partial dissociation of the eliciting conditions of the two types of SMEs and therefore provide a tool for future studies to characterize the different types of episodic encoding. PMID:28194105

ERP Subsequent Memory Effects Differ between Inter-Item and Unitization Encoding Tasks.

PubMed

Kamp, Siri-Maria; Bader, Regine; Mecklinger, Axel

2017-01-01

The "subsequent memory paradigm" is an analysis tool to identify brain activity elicited during episodic encoding that is associated with successful subsequent retrieval. Two commonly observed event-related potential "subsequent memory effects" (SMEs) are the parietal SME in the P300 time window and the frontal slow wave SME, but to date a clear characterization of the circumstances under which each SME is observed is missing. To test the hypothesis that the parietal SME occurs when aspects of an experience are unitized into a single item representation, while inter-item associative encoding is reflected in the frontal slow wave effect, participants were assigned to one of two conditions that emphasized one of the encoding types under otherwise matched study phases of a recognition memory experiment. Word pairs were presented either in the context of a definition that allowed to combine the word pairs into a new concept (unitization or item encoding) or together with a sentence frame (inter-item encoding). Performance on the recognition test did not differ between the groups. The parietal SME was only found in the definition group, supporting the idea that this SME occurs when the components of an association are integrated in a unitized item representation. An early prefrontal negativity also exhibited an SME only in this group, suggesting that the formation of novel units occurs through interactions of multiple brain areas. The frontal slow wave SME was pronounced in both groups and may thus reflect processes generally involved in encoding of associations. Our results provide evidence for a partial dissociation of the eliciting conditions of the two types of SMEs and therefore provide a tool for future studies to characterize the different types of episodic encoding.

Deepening Sleep by Hypnotic Suggestion

PubMed Central

Cordi, Maren J.; Schlarb, Angelika A.; Rasch, Björn

2014-01-01

Study Objectives: Slow wave sleep (SWS) plays a critical role in body restoration and promotes brain plasticity; however, it markedly declines across the lifespan. Despite its importance, effective tools to increase SWS are rare. Here we tested whether a hypnotic suggestion to “sleep deeper” extends the amount of SWS. Design: Within-subject, placebo-controlled crossover design. Setting: Sleep laboratory at the University of Zurich, Switzerland. Participants: Seventy healthy females 23.27 ± 3.17 y. Intervention: Participants listened to an auditory text with hypnotic suggestions or a control tape before napping for 90 min while high-density electroencephalography was recorded. Measurements and Results: After participants listened to the hypnotic suggestion to “sleep deeper” subsequent SWS was increased by 81% and time spent awake was reduced by 67% (with the amount of SWS or wake in the control condition set to 100%). Other sleep stages remained unaffected. Additionally, slow wave activity was significantly enhanced after hypnotic suggestions. During the hypnotic tape, parietal theta power increases predicted the hypnosis-induced extension of SWS. Additional experiments confirmed that the beneficial effect of hypnotic suggestions on SWS was specific to the hypnotic suggestion and did not occur in low suggestible participants. Conclusions: Our results demonstrate the effectiveness of hypnotic suggestions to specifically increase the amount and duration of slow wave sleep (SWS) in a midday nap using objective measures of sleep in young, healthy, suggestible females. Hypnotic suggestions might be a successful tool with a lower risk of adverse side effects than pharmacological treatments to extend SWS also in clinical and elderly populations. Citation: Cordi MJ, Schlarb AA, Rasch B. Deepening sleep by hypnotic suggestion. SLEEP 2014;37(6):1143-1152. PMID:24882909

Stimulus-induced transitions between spike-wave discharges and spindles with the modulation of thalamic reticular nucleus.

PubMed

Fan, Denggui; Wang, Qingyun; Su, Jianzhong; Xi, Hongguang

2017-12-01

It is believed that thalamic reticular nucleus (TRN) controls spindles and spike-wave discharges (SWD) in seizure or sleeping processes. The dynamical mechanisms of spatiotemporal evolutions between these two types of activity, however, are not well understood. In light of this, we first use a single-compartment thalamocortical neural field model to investigate the effects of TRN on occurrence of SWD and its transition. Results show that the increasing inhibition from TRN to specific relay nuclei (SRN) can lead to the transition of system from SWD to slow-wave oscillation. Specially, it is shown that stimulations applied in the cortical neuronal populations can also initiate the SWD and slow-wave oscillation from the resting states under the typical inhibitory intensity from TRN to SRN. Then, we expand into a 3-compartment coupled thalamocortical model network in linear and circular structures, respectively, to explore the spatiotemporal evolutions of wave states in different compartments. The main results are: (i) for the open-ended model network, SWD induced by stimulus in the first compartment can be transformed into sleep-like slow UP-DOWN and spindle states as it propagates into the downstream compartments; (ii) for the close-ended model network, weak stimulations performed in the first compartment can result in the consistent experimentally observed spindle oscillations in all three compartments; in contrast, stronger periodic single-pulse stimulations applied in the first compartment can induce periodic transitions between SWD and spindle oscillations. Detailed investigations reveal that multi-attractor coexistence mechanism composed of SWD, spindles and background state underlies these state evolutions. What's more, in order to demonstrate the state evolution stability with respect to the topological structures of neural network, we further expand the 3-compartment coupled network into 10-compartment coupled one, with linear and circular structures, and nearest-neighbor (NN) coupled network as well as its realization of small-world (SW) topology via random rewiring, respectively. Interestingly, for the cases of linear and circular connetivities, qualitatively similar results were obtained in addition to the more irregularity of firings. However, SWD can be eventually transformed into the consistent low-amplitude oscillations for both NN and SW networks. In particular, SWD evolves into the slow spindling oscillations and background tonic oscillations within the NN and SW network, respectively. Our modeling and simulation studies highlight the effect of network topology in the evolutions of SWD and spindling oscillations, which provides new insights into the mechanisms of cortical seizures development.

Hippocampal gamma-slow oscillation coupling in macaques during sedation and sleep.

PubMed

Richardson, Andrew G; Liu, Xilin; Weigand, Pauline K; Hudgins, Eric D; Stein, Joel M; Das, Sandhitsu R; Proekt, Alexander; Kelz, Max B; Zhang, Milin; Van der Spiegel, Jan; Lucas, Timothy H

2017-11-01

Behavioral and neurophysiological evidence suggests that the slow (≤1 Hz) oscillation (SO) during sleep plays a role in consolidating hippocampal (HIPP)-dependent memories. The effects of the SO on HIPP activity have been studied in rodents and cats both during natural sleep and during anesthetic administration titrated to mimic sleep-like slow rhythms. In this study, we sought to document these effects in primates. First, HIPP field potentials were recorded during ketamine-dexmedetomidine sedation and during natural sleep in three rhesus macaques. Sedation produced regionally-specific slow and gamma (∼40 Hz) oscillations with strong coupling between the SO phase and gamma amplitude. These same features were seen in slow-wave sleep (SWS), but the coupling was weaker and the coupled gamma oscillation had a higher frequency (∼70 Hz) during SWS. Second, electrical stimuli were delivered to HIPP afferents in the parahippocampal gyrus (PHG) during sedation to assess the effects of sleep-like SO on excitability. Gamma bursts after the peak of SO cycles corresponded to periods of increased gain of monosynaptic connections between the PHG and HIPP. However, the two PHG-HIPP connectivity gains during sedation were both substantially lower than when the animal was awake. We conclude that the SO is correlated with rhythmic excitation and inhibition of the PHG-HIPP network, modulating connectivity and gamma generators intrinsic to this network. Ketamine-dexmedetomidine sedation produces a similar effect, but with a decreased contribution of the PHG to HIPP activity and gamma generation. © 2017 Wiley Periodicals, Inc.

Effect of slow energy releasing on divergent detonation of Insensitive High Explosives

NASA Astrophysics Data System (ADS)

Hu, Xiaomian; Pan, Hao; Huang, Yong; Wu, Zihui

2014-03-01

There exists a slow energy releasing (SER) process in the slow reaction zone located behind the detonation wave due to the carbon cluster in the detonation products of Insensitive High Explosives (IHEs), and the process will affect the divergent detonation wave's propagation and the driving process of the explosives. To study the potential effect, a new artificial burn model including the SER process based on the programmed burn model is proposed in the paper. Quasi-steady analysis of the new model indicates that the nonlinearity of the detonation speed as a function of front curvature owes to the significant change of the reaction rate and the reaction zone length at the sonic state. What's more, in simulating the detonation of IHE JB-9014, the new model including the slow reaction can predict a slower jump-off velocity, in good agreement with the result of the test.

Source and path effects in the wave fields of tremor and explosions at Stromboli Volcano, Italy

USGS Publications Warehouse

Chouet, B.; Saccorotti, G.; Martini, M.; Dawson, P.; De Luca, G.; Milana, G.; Scarpa, R.

1997-01-01

The wave fields generated by Strombolian activity are investigated using data from small-aperture seismic arrays deployed on the north flank of Stromboli and data from seismic and pressure transducers set up near the summit crater. Measurements of slowness and azimuth as a function of time clearly indicate that the sources of tremor and explosions are located beneath the summit crater at depths shallower than 200 m with occasional bursts of energy originating from sources extending to a depth of 3 km. Slowness, azimuth, and particle motion measurements reveal a complex composition of body and surface waves associated with topography, structure, and source properties. Body waves originating at depths shallower than 200 m dominate the wave field at frequencies of 0.5-2.5 Hz, and surface waves generated by the surficial part of the source and by scattering sources distributed around the island dominate at frequencies above 2.5 Hz. The records of tremor and explosions are both dominated by SH motion. Far-field records from explosions start with radial motion, and near-field records from those events show dominantly horizontal motion and often start with a low-frequency (1-2 Hz) precursor characterized by elliptical particle motion, followed within a few seconds by a high-frequency radial phase (1-10 Hz) accompanying the eruption of pyroclastics. The dominant component of the near- and far-field particle motions from explosions, and the timing of air and body wave phases observed in the near field, are consistent with a gaspiston mechanism operating on a shallow (<200 m deep), vertical crack-like conduit. Models of a degassing fluid column suggest that noise emissions originating in the collective oscillations of bubbles ascending in the magma conduit may provide an adequate self-excitation mechanism for sustained tremor generation at Stromboli. Copyright 1997 by the American Geophysical Union.

A new B-dot probe-based diagnostic for amplitude, polarization, and wavenumber measurements of ion cyclotron range-of frequency fields on ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Ochoukov, R.; Bobkov, V.; Faugel, H.; Fünfgelder, H.; Noterdaeme, J.-M.

2015-11-01

A new B-dot probe-based diagnostic has been installed on an ASDEX Upgrade tokamak to characterize ion cyclotron range-of frequency (ICRF) wave generation and interaction with magnetized plasma. The diagnostic consists of a field-aligned array of B-dot probes, oriented to measure fast and slow ICRF wave fields and their field-aligned wavenumber (k//) spectrum on the low field side of ASDEX Upgrade. A thorough description of the diagnostic and the supporting electronics is provided. In order to compare the measured dominant wavenumber of the local ICRF fields with the expected spectrum of the launched ICRF waves, in-air near-field measurements were performed on the newly installed 3-strap ICRF antenna to reconstruct the dominant launched toroidal wavenumbers (ktor). Measurements during a strap current phasing scan in tokamak discharges reveal an upshift in k// as strap phasing is moved away from the dipole configuration. This result is the opposite of the ktor trend expected from in-air near-field measurements; however, the near-field based reconstruction routine does not account for the effect of induced radiofrequency (RF) currents in the passive antenna structures. The measured exponential increase in the local ICRF wave field amplitude is in agreement with the upshifted k//, as strap phasing moves away from the dipole configuration. An examination of discharges heated with two ICRF antennas simultaneously reveals the existence of beat waves at 1 kHz, as expected from the difference of the two antennas' operating frequencies. Beats are observed on both the fast and the slow wave probes suggesting that the two waves are coupled outside the active antennas. Although the new diagnostic shows consistent trends between the amplitude and the phase measurements in response to changes applied by the ICRF antennas, the disagreement with the in-air near-field measurements remains. An electromagnetic model is currently under development to address this issue.

A new B-dot probe-based diagnostic for amplitude, polarization, and wavenumber measurements of ion cyclotron range-of frequency fields on ASDEX Upgrade.

PubMed

Ochoukov, R; Bobkov, V; Faugel, H; Fünfgelder, H; Noterdaeme, J-M

2015-11-01

A new B-dot probe-based diagnostic has been installed on an ASDEX Upgrade tokamak to characterize ion cyclotron range-of frequency (ICRF) wave generation and interaction with magnetized plasma. The diagnostic consists of a field-aligned array of B-dot probes, oriented to measure fast and slow ICRF wave fields and their field-aligned wavenumber (k(//)) spectrum on the low field side of ASDEX Upgrade. A thorough description of the diagnostic and the supporting electronics is provided. In order to compare the measured dominant wavenumber of the local ICRF fields with the expected spectrum of the launched ICRF waves, in-air near-field measurements were performed on the newly installed 3-strap ICRF antenna to reconstruct the dominant launched toroidal wavenumbers (k(tor)). Measurements during a strap current phasing scan in tokamak discharges reveal an upshift in k(//) as strap phasing is moved away from the dipole configuration. This result is the opposite of the k(tor) trend expected from in-air near-field measurements; however, the near-field based reconstruction routine does not account for the effect of induced radiofrequency (RF) currents in the passive antenna structures. The measured exponential increase in the local ICRF wave field amplitude is in agreement with the upshifted k(//), as strap phasing moves away from the dipole configuration. An examination of discharges heated with two ICRF antennas simultaneously reveals the existence of beat waves at 1 kHz, as expected from the difference of the two antennas' operating frequencies. Beats are observed on both the fast and the slow wave probes suggesting that the two waves are coupled outside the active antennas. Although the new diagnostic shows consistent trends between the amplitude and the phase measurements in response to changes applied by the ICRF antennas, the disagreement with the in-air near-field measurements remains. An electromagnetic model is currently under development to address this issue.

Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro.

PubMed Central

Bal, T; von Krosigk, M; McCormick, D A

1995-01-01

1. The cellular basis for generation of spindle waves and a slower synchronized oscillation resembling absence seizures was investigated with extracellular and intracellular recording techniques in slices of ferret dorsal lateral geniculate nucleus (LGNd) maintained in vitro. 2. Intracellular recording from LGNd relay cells in vitro revealed that spindle waves occurred once every 3-30 s and were associated with barrages of inhibitory postsynaptic potentials (IPSPs) occurring at a frequency of 6-10 Hz. These IPSPs resulted in the generation of rebound low threshold Ca2+ spikes at 2-4 Hz, owing to the intrinsic propensity of LGNd relay cells to generate oscillatory burst firing in this frequency range. These rebound bursts of action potentials were highly synchronized with local multiunit and single unit activity. 3. The spindle wave-associated IPSPs in LGNd relay cells exhibited a mean reversal potential of -86 mV. This reversal potential was shifted to more depolarized membrane potentials with the intracellular injection of Cl- through the use of KCl-filled microelectrodes. Simultaneous recording from the perigeniculate nucleus (PGN) and LGNd revealed the IPSPs to be synchronous with the occurrence of burst firing in the PGN. Excitation of PGN neurons with local electrical stimulation after pharmacological block of excitatory amino acid transmission resulted in bicuculline-sensitive IPSPs in relay neurons similar in amplitude and time course to those occurring during spindle waves. 4. Application of (-)-bicuculline methiodide resulted in the abolition of spindle wave-associated IPSPs or in the slowing of the rate of rise, an increase in amplitude and a prolongation of these IPSPs; this resulted in a synchronized 2-4 Hz oscillation, in which each relay cell strongly burst on nearly every cycle, thus forming a paroxysmal event. Bath application of the GABAB receptor antagonist 2-OH-saclofen blocked these slowed oscillations, indicating that they are mediated by the activation of GABAB receptors. In contrast, pharmacological antagonism of GABAB receptors did not block the generation of normal spindle waves. 5. These and other results indicate that spindle waves are generated in the ferret LGNd in vitro as a network phenomenon occurring through an interaction between the relay cells of the LGNd and the GABAergic neurons of the PGN. We propose that burst firing in PGN cells hyperpolarizes relay neurons through activation of GABAA receptors. These IPSPs result in rebound burst firing in LGNd cells, which then excite PGN neurons.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:7776249

Observations and analyses of an intense waves-in-ice event in the Sea of Okhotsk

NASA Astrophysics Data System (ADS)

Marko, John R.

2003-09-01

Ice draft, ice velocity, ice concentration, and current profile data gathered at an array of eight continental shelf monitoring sites east of Sakhalin Island were analyzed in conjunction with regional meteorological data to document and explain intense wave occurrences several hundred kilometers inside the Sea of Okhotsk ice pack. The studied event was associated with the 19-21 March 1998 passage of an intense cyclone, which produced waves with amplitudes in excess of 1 m at the most offshore monitoring location. The relatively monochromatic character of the waves allowed extraction of wave intensity time series from ice draft time series data. Spatial and temporal variations in these data were used to establish directions and speeds of wave energy propagation for comparisons with an earlier interpretation [, 1988] of an Antarctic intense waves-in-ice event. It was concluded that although both events are compatible with a two-stage process in which initially slowly advancing wave activity increases subsequent ice cover wave transmissivity, the first stage of the Sea of Okhotsk event was not explicable in terms of the static stress-induced changes in the waves-in-ice dispersion relationship proposed by Liu and Mollo-Christensen. An alternative explanation is offered that eschews the linkage between wave group velocities and the observed slow rates of wave energy propagation and attributes the subsequent transition to more normal wave propagation behavior to ice pack divergence.

Long-wave equivalent viscoelastic solids for porous rocks saturated by two-phase fluids

NASA Astrophysics Data System (ADS)

Santos, J. E.; Savioli, G. B.

2018-04-01

Seismic waves traveling across fluid-saturated poroelastic materials with mesoscopic-scale heterogeneities induce fluid flow and Biot's slow waves generating energy loss and velocity dispersion. Using Biot's equations of motion to model these type of heterogeneities would require extremely fine meshes. We propose a numerical upscaling procedure to determine the complex and frequency dependent P-wave and shear moduli of an effective viscoelastic medium long-wave equivalent to a poroelastic solid saturated by a two-phase fluid. The two-phase fluid is defined in terms of capillary pressure and relative permeability flow functions. The P-wave and shear effective moduli are determined using harmonic compressibility and shear experiments applied on representative samples of the bulk material. Each experiment is associated with a boundary value problem that is solved using the finite element method. Since a poroelastic solid saturated by a two-phase fluid supports the existence of two slow waves, this upscaling procedure allows to analyze their effect on the mesoscopic-loss mechanism in hydrocarbon reservoir formations. Numerical results show that a two-phase Biot medium model predicts higher attenuation than classic Biot models.

Slow-wave metamaterial open panels for efficient reduction of low-frequency sound transmission

NASA Astrophysics Data System (ADS)

Yang, Jieun; Lee, Joong Seok; Lee, Hyeong Rae; Kang, Yeon June; Kim, Yoon Young

2018-02-01

Sound transmission reduction is typically governed by the mass law, requiring thicker panels to handle lower frequencies. When open holes must be inserted in panels for heat transfer, ventilation, or other purposes, the efficient reduction of sound transmission through holey panels becomes difficult, especially in the low-frequency ranges. Here, we propose slow-wave metamaterial open panels that can dramatically lower the working frequencies of sound transmission loss. Global resonances originating from slow waves realized by multiply inserted, elaborately designed subwavelength rigid partitions between two thin holey plates contribute to sound transmission reductions at lower frequencies. Owing to the dispersive characteristics of the present metamaterial panels, local resonances that trap sound in the partitions also occur at higher frequencies, exhibiting negative effective bulk moduli and zero effective velocities. As a result, low-frequency broadened sound transmission reduction is realized efficiently in the present metamaterial panels. The theoretical model of the proposed metamaterial open panels is derived using an effective medium approach and verified by numerical and experimental investigations.

Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves

NASA Astrophysics Data System (ADS)

Restrepo, Simon; Basler, Konrad

2016-08-01

Calcium signalling is a highly versatile cellular communication system that modulates basic functions such as cell contractility, essential steps of animal development such as fertilization and higher-order processes such as memory. We probed the function of calcium signalling in Drosophila wing imaginal discs through a combination of ex vivo and in vivo imaging and genetic analysis. Here we discover that wing discs display slow, long-range intercellular calcium waves (ICWs) when mechanically stressed in vivo or cultured ex vivo. These slow imaginal disc intercellular calcium waves (SIDICs) are mediated by the inositol-3-phosphate receptor, the endoplasmic reticulum (ER) calcium pump SERCA and the key gap junction component Inx2. The knockdown of genes required for SIDIC formation and propagation negatively affects wing disc recovery after mechanical injury. Our results reveal a role for ICWs in wing disc homoeostasis and highlight the utility of the wing disc as a model for calcium signalling studies.

Effects of transport coefficients on excitation of flare-induced standing slow-mode waves

NASA Astrophysics Data System (ADS)

Wang, Tongjiang; Ofman, Leon; Davila, Joseph

2017-08-01

The flare-excited longitudinal intensity oscillations in hot flaring loops have been recently detected by SDO/AIA, and interpreted as the slow-mode standing waves. By means of the seismology technique we have, for the first time, determined the transport coefficients in the hot (>9 MK) flare plasma, and found that thermal conductivity is suppressed by at least 3 times and viscosity coefficient is enhanced by a factor of 15 as the upper limit (Wang et al. 2015, ApJL, 811, L13). In this presentation, we first discuss possible causes for conduction suppression and viscosity enhancements. Then we use the nonlinear MHD simulations to validate the seismology method that is based on linear analytical analysis, and demonstrate the inversion scheme for determining transport coefficients using numerical parametric study. Finally, we show how the seismologically-determined transport coefficients are crucial for understanding the excitation of the observed standing slow-mode waves in coronal loops and the heating of the loop plasma by a footpoint flare.

Midazolam or diazepam administration during electroencephalography helps to diagnose subacute sclerosing panencephalitis (SSPE).

PubMed

Yilmaz, Kutluhan; Sahin, Derya Aydin

2010-08-01

Although diagnostic contribution of intravenous diazepam administration during electroencephalography (EEG) recording in subacute sclerosing panencephalitis has been known, no another drug with less potential side effects has been studied in this procedure. In this study, diazepam is compared with midazolam in 25 subacute sclerosing panencephalitis-diagnosed children and 10 children with subacute sclerosing panencephalitis-suggesting symptoms, normal EEG findings and no certain diagnosis. Neither midazolam nor diazepam affected typical periodic slow-wave complexes. However, in the patients with atypical EEG abnormalities, midazolam, like diazepam, attenuated sharp or sharp-and-slow waves, and therefore made the identification of periodic slow-wave paroxysms easier. In the patients with normal EEGs, both midazolam and diazepam revealed typical periodic complexes on EEG recording in the same 3 patients. Cerebrospinal fluid examination verified the diagnosis of subacute sclerosing panencephalitis. The findings suggest that midazolam or diazepam administration increases the contribution of EEG recording in atypical cases with subacute sclerosing panencephalitis.

Observation and excitation of magnetohydrodynamic waves in numerical models of Earth's core

NASA Astrophysics Data System (ADS)

Teed, R.; Hori, K.; Tobias, S.; Jones, C. A.

2017-12-01

Several types of magnetohydrodynamic waves are theorised to operate in Earth's outer core but their detection is limited by the inability to probe the fluid core directly. Secular variation data and periodic changes in Earth's length-of-day provide evidence for the possible existence of waves. Numerical simulations of core dynamics enable us to search directly for waves and determine their properties. With this information it is possible to consider whether they can be the origin of features observed in observational data. We focus on two types of wave identified in our numerical experiments: i) torsional waves and ii) slow magnetic Rossby waves. Our models display periodic, Earth-like torsional waves that travel outwards from the tangent cylinder circumscribing the inner core. We discuss the properties of these waves and their similarites to observational data. Excitation is via a matching of the Alfvén frequency with that of small modes of convection focused at the tangent cylinder. The slow magnetic Rossby waves observed in our simulations show that these waves may account for some geomagnetic westward drifts observed at mid-latitudes. We present analysis showing excitation of waves by the convective instability and we discuss how the detection of these waves could also provide an estimate of the strength of the toroidal component of the magnetic field within the planetary fluid core.

Expansion Under Climate Change: The Genetic Consequences.

PubMed

Garnier, Jimmy; Lewis, Mark A

2016-11-01

Range expansion and range shifts are crucial population responses to climate change. Genetic consequences are not well understood but are clearly coupled to ecological dynamics that, in turn, are driven by shifting climate conditions. We model a population with a deterministic reaction-diffusion model coupled to a heterogeneous environment that develops in time due to climate change. We decompose the resulting travelling wave solution into neutral genetic components to analyse the spatio-temporal dynamics of its genetic structure. Our analysis shows that range expansions and range shifts under slow climate change preserve genetic diversity. This is because slow climate change creates range boundaries that promote spatial mixing of genetic components. Mathematically, the mixing leads to so-called pushed travelling wave solutions. This mixing phenomenon is not seen in spatially homogeneous environments, where range expansion reduces genetic diversity through gene surfing arising from pulled travelling wave solutions. However, the preservation of diversity is diminished when climate change occurs too quickly. Using diversity indices, we show that fast expansions and range shifts erode genetic diversity more than slow range expansions and range shifts. Our study provides analytical insight into the dynamics of travelling wave solutions in heterogeneous environments.

Slow wave structures integrated with ferromagnetic and ferro-electric thin films for smart RF applications

NASA Astrophysics Data System (ADS)

Rahman, B. M. Farid

Modern communications systems are following a common trend to increase the operational frequency, level of integration and number of frequency bands. Although 90-95% components in a cell phone are passives which take 80% of the total board area. High performance RF passive components play limited role and are desired towards this technological advancement. Slow wave structure is one of the most promising candidates to design compact RF and mm-Wave passive components. Slow wave structures are the specially designed transmission line realized by placing the alternate narrow and wide signal conductors in order to reduce the physical size of the components. This dissertation reports multiband slow wave structures integrated with ferromagnetic and ferroelectric thin films and their RF applications. A comparative study on different types of coplanar wave-guide (CPW) slow wave structures (SWS) has been demonstrated for the first time. Slow wave structures with various shapes have been investigated and optimized with various signal conductor shapes, ground conductor shapes and pitch of the sections. Novel techniques i.e. the use of the defected ground structure and the different signal conductor length has been implemented to achieve higher slow wave effect with minimum loss. The measured results have shown the reduction of size over 43.47% and 37.54% in the expense of only 0.27dB and 0.102dB insertion loss respectively which can reduce the area of a designed branch line coupler by 68% and 61% accordingly. Permalloy (Py) is patterned on top of the developed SWS for the first time to further increase the slow wave effect and provide tunable inductance value. High frequency applications of Py are limited by its ferro-magnetic resonance frequency since the inductance value decreases beyond that. Sub-micrometer patterning of Py has increased FMR frequency until 6.3GHz and 3.2GHz by introducing the shape anisotropy. For the SWS with patterned Py, the size of the quarter wavelength has been reduced from 14.86mm to 4.7mm at 2GHz. DC current which is the most convenient and available tuning parameter in a practical circuit board has been used, the developed SWS can function as quarter wave transmission line from 2GHz to 1.80GHz (i.e. 10%). Lead Zirconium Titanate (PZT) is grown and patterned on top of the section with standard sol-gel method to increase capacitance value. The inter digit capacitor type structure along with PZT thin film has been adopted and results showed capacitance value increment by 36%. An electric field between signal and ground has been applied to change the polarization of the thin film which resulted in a tuning of center frequency by 15% (1.75GHz to 2GHz). In addition, a novel approach has been implemented by integrating both the ferromagnetic and the ferroelectric thin films simultaneously to achieve higher slow wave effect, wider tuning range and smaller variation in Characteristics Impedance. The size of the final structure for a quarter wavelengths has been reduced from 14.86mm to 3.98mm while the center frequency has been tuned from 2GHz to 1.5GHz (i.e. 25%). Tunable RF applications of the ferro-magnetic thin films are also demonstrated as a DC current band pass filter, tunable noise suppressor and meander line inductor. A well designed frequency tunable band pass filter (BPF) is implemented at 4GHz with patterned Permalloy. The pass band frequency of a band pass filter has been tuned from 4GHz to 4.02GHz by applying a DC current. The suppression frequency of the developed noise suppressor is tuned from 4.8GHz to 6GHz and 4GHz to 6GHz by changing the aspect ratio of the Py bars and the gap in between them. Moreover, a novel way of tuning the stop band frequency of the noise suppressor by using an external direct current changed the suppression frequency from 6GHz to 4.3GHz. A pass band loss of 1.5%, less than 2° transmitted signal phase distortion, and 3 dB extra return loss of the designed noise suppressor showed the promise the noise suppressors. The increase in the number of turns of a meander line inductor has increased the inductance density from 2565nH/m to 3396nH/m while application of the patterned Py has increased the inductance density from 2565nH/m to 3060nH/m. The tuning of the meander line inductor has been performed by applying DC current until the FMR frequency 4.51GHz.

Intrinsic Brain Activity in Altered States of Consciousness

PubMed Central

Boly, M.; Phillips, C.; Tshibanda, L.; Vanhaudenhuyse, A.; Schabus, M.; Dang-Vu, T.T.; Moonen, G.; Hustinx, R.; Maquet, P.; Laureys, S.

2010-01-01

Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting-state studies to a better understanding of brain–behavior relationships has been challenged. That altered states of consciousness are a privileged way to study the relationships between spontaneous brain activity and behavior is proposed, and common resting-state brain activity features observed in various states of altered consciousness are reviewed. Early positron emission tomography studies showed that states of extremely low or high brain activity are often associated with unconsciousness. However, this relationship is not absolute, and the precise link between global brain metabolism and awareness remains yet difficult to assert. In contrast, voxel-based analyses identified a systematic impairment of associative frontoparieto–cingulate areas in altered states of consciousness, such as sleep, anesthesia, coma, vegetative state, epileptic loss of consciousness, and somnambulism. In parallel, recent functional magnetic resonance imaging studies have identified structured patterns of slow neuronal oscillations in the resting human brain. Similar coherent blood oxygen level–dependent (BOLD) systemwide patterns can also be found, in particular in the default-mode network, in several states of unconsciousness, such as coma, anesthesia, and slow-wave sleep. The latter results suggest that slow coherent spontaneous BOLD fluctuations cannot be exclusively a reflection of conscious mental activity, but may reflect default brain connectivity shaping brain areas of most likely interactions in a way that transcends levels of consciousness, and whose functional significance remains largely in the dark. PMID:18591474

Urodynamic function during sleep-like brain states in urethane anesthetized rats.

PubMed

Crook, J; Lovick, T

2016-01-28

The aim was to investigate urodynamic parameters and functional excitability of the periaqueductal gray matter (PAG) during changes in sleep-like brain states in urethane anesthetized rats. Simultaneous recordings of detrusor pressure, external urethral sphincter (EUS) electromyogram (EMG), cortical electroencephalogram (EEG), and single-unit activity in the PAG were made during repeated voiding induced by continuous infusion of saline into the bladder. The EEG cycled between synchronized, high-amplitude slow wave activity (SWA) and desynchronized low-amplitude fast activity similar to slow wave and 'activated' sleep-like brain states. During (SWA, 0.5-1.5 Hz synchronized oscillation of the EEG waveform) voiding became more irregular than in the 'activated' brain state (2-5 Hz low-amplitude desynchronized EEG waveform) and detrusor void pressure threshold, void volume threshold and the duration of bursting activity in the external urethral sphincter EMG were raised. The spontaneous firing rate of 23/52 neurons recorded within the caudal PAG and adjacent tegmentum was linked to the EEG state, with the majority of responsive cells (92%) firing more slowly during SWA. Almost a quarter of the cells recorded (12/52) showed phasic changes in firing rate that were linked to the occurrence of voids. Inhibition (n=6), excitation (n=4) or excitation/inhibition (n=2) was seen. The spontaneous firing rate of 83% of the micturition-responsive cells was sensitive to changes in EEG state. In nine of the 12 responsive cells (75%) the responses were reduced during SWA. We propose that during different sleep-like brain states changes in urodynamic properties occur which may be linked to changing excitability of the micturition circuitry in the periaqueductal gray. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

SLOW PATCHY EXTREME-ULTRAVIOLET PROPAGATING FRONTS ASSOCIATED WITH FAST CORONAL MAGNETO-ACOUSTIC WAVES IN SOLAR ERUPTIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Y.; Ding, M. D.; Chen, P. F., E-mail: guoyang@nju.edu.cn

2015-08-15

Using the high spatiotemporal resolution extreme ultraviolet (EUV) observations of the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory, we conduct a statistical study of the observational properties of the coronal EUV propagating fronts. We find that it might be a universal phenomenon for two types of fronts to coexist in a large solar eruptive event. It is consistent with the hybrid model of EUV propagating fronts, which predicts that coronal EUV propagating fronts consist of both a fast magneto-acoustic wave and a nonwave component. We find that the morphologies, propagation behaviors, and kinematic features of the two EUVmore » propagating fronts are completely different from each other. The fast magneto-acoustic wave fronts are almost isotropic. They travel continuously from the flaring region across multiple magnetic polarities to global distances. On the other hand, the slow nonwave fronts appear as anisotropic and sequential patches of EUV brightening. Each patch propagates locally in the magnetic domains where the magnetic field lines connect to the bottom boundary and stops at the magnetic domain boundaries. Within each magnetic domain, the velocities of the slow patchy nonwave component are an order of magnitude lower than that of the fast-wave component. However, the patches of the slow EUV propagating front can jump from one magnetic domain to a remote one. The velocities of such a transit between different magnetic domains are about one-third to one-half of those of the fast-wave component. The results show that the velocities of the nonwave component, both within one magnetic domain and between different magnetic domains, are highly nonuniform due to the inhomogeneity of the magnetic field in the lower atmosphere.« less

The effects of strong temperature anisotropy on the kinetic structure of collisionless slow shocks and reconnection exhausts. II. Theory

NASA Astrophysics Data System (ADS)

Liu, Yi-Hsin; Drake, J. F.; Swisdak, M.

2011-09-01

Simulations of collisionless oblique propagating slow shocks have revealed the existence of a transition associated with a critical temperature anisotropy ɛ = 1 - μ0(P|| - P⊥)/B2 = 0.25 (Y.-H. Liu, J. F. Drake, and M. Swisdak, Phys. Plasmas 18, 062110 (2011)). An explanation for this phenomenon is proposed here based on anisotropic fluid theory, in particular, the anisotropic derivative nonlinear-Schrödinger-Burgers equation, with an intuitive model of the energy closure for the downstream counter-streaming ions. The anisotropy value of 0.25 is significant because it is closely related to the degeneracy point of the slow and intermediate modes and corresponds to the lower bound of the coplanar to non-coplanar transition that occurs inside a compound slow shock (SS)/rotational discontinuity (RD) wave. This work implies that it is a pair of compound SS/RD waves that bound the outflows in magnetic reconnection, instead of a pair of switch-off slow shocks as in Petschek's model. This fact might explain the rareness of in-situ observations of Petschek-reconnection-associated switch-off slow shocks.

Instabilities in dynamic anti-plane sliding of an elastic layer on a dissimilar elastic half-space

NASA Astrophysics Data System (ADS)

Kunnath, R.

2012-12-01

The stability of dynamic anti-plane sliding at an interface between an elastic layer and an elastic half-space with dissimilar elastic properties is studied. Friction at the interface is assumed to follow a rate- and state-dependent law, with a positive instantaneous dependence on slip velocity and a rate weakening behavior in the steady state. The perturbations are of the form exp(ikx+pt), where k is the wavenumber, x is the coordinate along the interface, p is the time response to the perturbation and t is time. The results of the stability analysis are shown in Figs. 1 and 2 with the velocity weakening parameter b/a=5, shear wave speed ratio cs'/cs=1.2, shear modulus ratio μ'/μ=1.2 and non-dimensional layer thickness H=100. The normalized instability growth rate and normalized phase velocity are plotted as a function of wavenumber. Fig.1 is for a non-dimensional unperturbed slip velocity ɛ=5 (rapid sliding) while Fig. 2 is for ɛ=0.05 (slow sliding). The results show the destabilization of interfacial waves. For slow sliding, destabilization of interfacial waves is still seen, indicating that the quasi-static approximation to slow sliding is not valid. This is in agreement with the result of Ranjith (Int. J. Solids and Struct., 2009, 46, 3086-3092) who predicted an instability of long-wavelength Love waves in slow sliding.

ERPs Differentially Reflect Automatic and Deliberate Processing of the Functional Manipulability of Objects

PubMed Central

Madan, Christopher R.; Chen, Yvonne Y.; Singhal, Anthony

2016-01-01

It is known that the functional properties of an object can interact with perceptual, cognitive, and motor processes. Previously we have found that a between-subjects manipulation of judgment instructions resulted in different manipulability-related memory biases in an incidental memory test. To better understand this effect we recorded electroencephalography (EEG) while participants made judgments about images of objects that were either high or low in functional manipulability (e.g., hammer vs. ladder). Using a between-subjects design, participants judged whether they had seen the object recently (Personal Experience), or could manipulate the object using their hand (Functionality). We focused on the P300 and slow-wave event-related potentials (ERPs) as reflections of attentional allocation. In both groups, we observed higher P300 and slow wave amplitudes for high-manipulability objects at electrodes Pz and C3. As P300 is thought to reflect bottom-up attentional processes, this may suggest that the processing of high-manipulability objects recruited more attentional resources. Additionally, the P300 effect was greater in the Functionality group. A more complex pattern was observed at electrode C3 during slow wave: processing the high-manipulability objects in the Functionality instruction evoked a more positive slow wave than in the other three conditions, likely related to motor simulation processes. These data provide neural evidence that effects of manipulability on stimulus processing are further mediated by automatic vs. deliberate motor-related processing. PMID:27536224

Shear-wave velocity structure of the Tongariro Volcanic Centre, New Zealand: Fast Rayleigh and slow Love waves indicate strong shallow anisotropy

NASA Astrophysics Data System (ADS)

Godfrey, Holly J.; Fry, Bill; Savage, Martha K.

2017-04-01

Models of the velocity structure of volcanoes can help define possible magma pathways and contribute to calculating more accurate earthquake locations, which can help with monitoring volcanic activity. However, shear-wave velocity of volcanoes is difficult to determine from traditional seismic techniques, such as local earthquake tomography (LET) or refraction/reflection surveys. Here we use the recently developed technique of noise cross correlation of continuous seismic data to investigate the subsurface shear-wave velocity structure of the Tongariro Volcanic Centre (TgVC) of New Zealand, focusing on the active Ruapehu and Tongariro Volcanoes. We observe both the fundamental and first higher-order modes of Rayleigh and Love waves within our noise dataset, made from stacks of 15 min cross-correlation functions. We manually pick group velocity dispersion curves from over 1900 correlation functions, of which we consider 1373 to be high quality. We subsequently invert a subset of the fundamental mode Rayleigh- and Love-wave dispersion curves both independently and jointly for one dimensional shear-wave velocity (Vs) profiles at Ruapehu and Tongariro Volcanoes. Vs increases very slowly at a rate of approximately 0.2 km/s per km depth beneath Ruapehu, suggesting that progressive hydrothermal alteration mitigates the effects of compaction driven velocity increases. At Tongariro, we observe larger Vs increases with depth, which we interpret as different layers within Tongariro's volcanic system above altered basement greywacke. Slow Vs, on the order of 1-2 km/s, are compatible with P-wave velocities (using a Vp/Vs ratio of 1.7) from existing velocity profiles of areas within the TgVC, and the observations of worldwide studies of shallow volcanic systems that used ambient noise cross-correlation methods. Most of the measured group velocities of fundamental mode Love-waves across the TgVC are 0.1-0.4 km/s slower than those of fundamental mode Rayleigh-waves in the frequency range of 0.25-1 Hz. First-higher mode Love-waves are similarly slower than first-higher mode Rayleigh waves. This is incompatible with synthetic dispersion curves we calculate using isotropic, layered velocity models appropriate for Ruapehu and Tongariro, in which Love waves travel more quickly than Rayleigh waves of the same period. The Love-Rayleigh discrepancy is likely due to structures such as dykes or cracks in the vertical plane having increased influence on surface-wave propagation. However, several measurements at Ruapehu have Love-wave group velocities that are faster than Rayleigh-wave group velocities. The differences between the Love- and Rayleigh-wave dispersion curves also vary with the azimuth of the interstation path across Ruapehu and Tongariro Volcanoes. Significant azimuthal dependence of both Love and Rayleigh-wave velocities are also observed. This suggests azimuthal anisotropy within the volcanic structures, which coupled with radial anisotropy, makes the Vs structures of Ruapehu and Tongariro Volcanoes anisotropic with orthorhombic or lower order symmetry. We suggest that further work to determine three-dimensional volcanic structures should include provisions for such anisotropy.

The Direct Digital Modulation of Traveling Wave Tubes

NASA Technical Reports Server (NTRS)

Radhamohan, Ranjan S.

2004-01-01

Traveling wave tube (TWT) technology, first described by Rudolf Kompfner in the early 1940s, has been a key component of space missions from the earliest communication satellites in the 1960s to the Cassini probe today. TWTs are essentially signal amplifiers that have the special capability of operating at microwave frequencies. The microwave frequency range, which spans from approximately 500 MHz to 300 GHz, is shared by many technologies including cellular phones, satellite television, space communication, and radar. TWT devices are superior in reliability, weight, and efficiency to solid-state amplifiers at the high power and frequency levels required for most space missions. TWTs have three main components -an electron gun, slow wave structure, and collector. The electron gun generates an electron beam that moves along the length of the tube axis, inside of the slow wave circuit. At the same time, the inputted signal is slowed by its travel through the coils of the helical slow wave circuit. The interaction of the electron beam and this slowed signal produces a transfer of kinetic energy to the signal, and in turn, amplification. At the end of its travel, the spent electron beam moves into the collector where its remaining energy is dissipated as heat or harnessed for reuse. TWTs can easily produce gains in the tens of decibels, numbers that are suitable for space missions. To date, however, TWTs have typically operated at fixed levels of gain. This gain is determined by various, unchanging, physical factors of the tube. Traditionally, to achieve varying gain, an input signal s amplitude has had to first be modulated by a separate device before being fed into the TWT. This is not always desirable, as significant distortion can occur in certain situations. My mentor, Mr. Dale Force, has proposed an innovative solution to this problem called direct digital modulation . The testing and implementation of this solution is the focus of my summer internship. The direct digital modulation of a TWT removes the need for a separate amplitude modulation device. Instead, different levels of gain are achieved by varying the electron beam current. The lower the current, the less kinetic energy is available to be transferred to the signal. To vary the current, a grid is placed in-between the electron gun and the slow wave circuit. By changing the voltage across the grid, the electron beam current can be controlled. Grid technology has mostly been used in pulse applications such as radar, where only two voltage states are necessary. For direct digital modulation, however, a continuous range of voltages is required.

Consciousness and Complexity during Unresponsiveness Induced by Propofol, Xenon, and Ketamine.

PubMed

Sarasso, Simone; Boly, Melanie; Napolitani, Martino; Gosseries, Olivia; Charland-Verville, Vanessa; Casarotto, Silvia; Rosanova, Mario; Casali, Adenauer Girardi; Brichant, Jean-Francois; Boveroux, Pierre; Rex, Steffen; Tononi, Giulio; Laureys, Steven; Massimini, Marcello

2015-12-07

A common endpoint of general anesthetics is behavioral unresponsiveness, which is commonly associated with loss of consciousness. However, subjects can become disconnected from the environment while still having conscious experiences, as demonstrated by sleep states associated with dreaming. Among anesthetics, ketamine is remarkable in that it induces profound unresponsiveness, but subjects often report "ketamine dreams" upon emergence from anesthesia. Here, we aimed at assessing consciousness during anesthesia with propofol, xenon, and ketamine, independent of behavioral responsiveness. To do so, in 18 healthy volunteers, we measured the complexity of the cortical response to transcranial magnetic stimulation (TMS)--an approach that has proven helpful in assessing objectively the level of consciousness irrespective of sensory processing and motor responses. In addition, upon emergence from anesthesia, we collected reports about conscious experiences during unresponsiveness. Both frontal and parietal TMS elicited a low-amplitude electroencephalographic (EEG) slow wave corresponding to a local pattern of cortical activation with low complexity during propofol anesthesia, a high-amplitude EEG slow wave corresponding to a global, stereotypical pattern of cortical activation with low complexity during xenon anesthesia, and a wakefulness-like, complex spatiotemporal activation pattern during ketamine anesthesia. Crucially, participants reported no conscious experience after emergence from propofol and xenon anesthesia, whereas after ketamine they reported long, vivid dreams unrelated to the external environment. These results are relevant because they suggest that brain complexity may be sensitive to the presence of disconnected consciousness in subjects who are considered unconscious based on behavioral responses. Copyright © 2015 Elsevier Ltd. All rights reserved.

Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice

PubMed Central

Tsunematsu, Tomomi; Kilduff, Thomas S.; Boyden, Edward S.; Takahashi, Satoru; Tominaga, Makoto; Yamanaka, Akihiro

2013-01-01

Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated transgenic mice in which orexin neurons expressed halorhodopsin (orexin/Halo mice), an orange light-activated neuronal silencer. Slice patch-clamp recordings of orexin neurons that expressed halorhodopsin demonstrated that orange light photic illumination immediately hyperpolarized membrane potential and inhibited orexin neuron discharge in proportion to illumination intensity. Acute silencing of orexin neurons in vivo during the day (the inactive period) induced synchronization of the electroencephalogram and a reduction in amplitude of the electromyogram that is characteristic of slow-wave sleep (SWS). In contrast, orexin neuron photoinhibition was ineffective during the night (active period). Acute photoinhibition of orexin neurons during the day in orexin/Halo mice also reduced discharge of neurons in an orexin terminal field, the dorsal raphe (DR) nucleus. However, serotonergic DR neurons exhibited normal discharge rates in mice lacking orexin neurons. Thus, although usually highly dependent on orexin neuronal activity, serotonergic DR neuronal activity can be regulated appropriately in the chronic absence of orexin input. Together, these results demonstrate that acute inhibition of orexin neurons results in time-of-day-dependent induction of SWS and in reduced firing rate of neurons in an efferent projection site thought to be involved in arousal state regulation. The results presented here advance our understanding of the role of orexin neurons in the regulation of sleep/wakefulness and may be relevant to the mechanisms that underlie symptom progression in narcolepsy. PMID:21775598

Coronal Seismology of Flare-Excited Standing Slow-Mode Waves Observed by SDO/AIA

NASA Astrophysics Data System (ADS)

Wang, Tongjiang; Ofman, Leon; Davila, Joseph M.

2016-05-01

Flare-excited longitudinal intensity oscillations in hot flaring loops have been recently detected by SDO/AIA in 94 and 131 Å bandpasses. Based on the interpretation in terms of a slow-mode wave, quantitative evidence of thermal conduction suppression in hot (>9 MK) loops has been obtained for the first time from measurements of the polytropic index and phase shift between the temperature and density perturbations (Wang et al. 2015, ApJL, 811, L13). This result has significant implications in two aspects. One is that the thermal conduction suppression suggests the need of greatly enhanced compressive viscosity to interpret the observed strong wave damping. The other is that the conduction suppression provides a reasonable mechanism for explaining the long-duration events where the thermal plasma is sustained well beyond the duration of impulsive hard X-ray bursts in many flares, for a time much longer than expected by the classical Spitzer conductive cooling. In this study, we model the observed standing slow-mode wave in Wang et al. (2015) using a 1D nonlinear MHD code. With the seismology-derived transport coefficients for thermal conduction and compressive viscosity, we successfully simulate the oscillation period and damping time of the observed waves. Based on the parametric study of the effect of thermal conduction suppression and viscosity enhancement on the observables, we discuss the inversion scheme for determining the energy transport coefficients by coronal seismology.

Ambient noise tomography reveals upper crustal structure of Icelandic rifts

NASA Astrophysics Data System (ADS)

Green, Robert G.; Priestley, Keith F.; White, Robert S.

2017-05-01

The structure of oceanic spreading centres and subsurface melt distribution within newly formed crust is largely understood from marine seismic experiments. In Iceland, however, sub-aerial rift elevation allows both accurate surface mapping and the installation of large broadband seismic arrays. We present a study using ambient noise Rayleigh wave tomography to image the volcanic spreading centres across Iceland. Our high resolution model images a continuous band of low seismic velocities, parallelling all three segments of the branched rift in Iceland. The upper 10 km contains strong velocity variations, with shear wave velocities 0.5 km s-1 faster in the older non-volcanically active regions compared to the active rifts. Slow velocities correlate very closely with geological surface mapping, with contours of the anomalies parallelling the edges of the neo-volcanic zones. The low-velocity band extends to the full 50 km width of the neo-volcanic zones, demonstrating a significant contrast with the narrow (8 km wide) magmatic zone seen at fast spreading ridges, where the rate of melt supply is similarly high. Within the seismically slow rift band, the lowest velocity cores of the anomalies occur above the centre of the mantle plume under the Vatnajökull icecap, and in the Eastern Volcanic Zone under the central volcano Katla. This suggests localisation of melt accumulation at these specific volcanic centres, demonstrating variability in melt supply into the shallow crust along the rift axis. Shear velocity inversions with depth show that the strongest velocity contrasts are found in the upper 8 km, and show a slight depression in the shear velocity through the mid crust (10-20 km) in the rifts. Our model also shows less intensity to the slow rift anomaly in the Western Volcanic Zone, supporting the notion that rift activity here is decreasing as the ridge jumps to the Eastern Volcanic Zone.

Fear Extinction Memory Consolidation Requires Potentiation of Pontine-Wave Activity during REM Sleep

PubMed Central

Datta, Subimal; O'Malley, Matthew W .

2013-01-01

Sleep plays an important role in memory consolidation within multiple memory systems including contextual fear extinction memory, but little is known about the mechanisms that underlie this process. Here, we show that fear extinction training in rats, which extinguished conditioned fear, increased both slow-wave sleep and rapid-eye movement (REM) sleep. Surprisingly, 24 h later, during memory testing, only 57% of the fear-extinguished animals retained fear extinction memory. We found that these animals exhibited an increase in phasic pontine-wave (P-wave) activity during post-training REM sleep, which was absent in the 43% of animals that failed to retain fear extinction memory. The results of this study provide evidence that brainstem activation, specifically potentiation of phasic P-wave activity, during post-training REM sleep is critical for consolidation of fear extinction memory. The results of this study also suggest that, contrary to the popular hypothesis of sleep and memory, increased sleep after training alone does not guarantee consolidation and/or retention of fear extinction memory. Rather, the potentiation of specific sleep-dependent physiological events may be a more accurate predictor for successful consolidation of fear extinction memory. Identification of this unique mechanism will significantly improve our present understanding of the cellular and molecular mechanisms that underlie the sleep-dependent regulation of emotional memory. Additionally, this discovery may also initiate development of a new, more targeted treatment method for clinical disorders of fear and anxiety in humans that is more efficacious than existing methods such as exposure therapy that incorporate only fear extinction. PMID:23467372

Efficiency enhancement of slow-wave electron-cyclotron maser by a second-order shaping of the magnetic field in the low-gain limit

NASA Astrophysics Data System (ADS)

Liu, Si-Jia; Zhang, Yu-Fei; Wang, Kang; Li, Yong-Ming; Jing, Jian

2017-03-01

Based on the anomalous Doppler effect, we put forward a proposal to enhance the conversion efficiency of the slow-wave electron cyclotron masers (ECM) under the resonance condition. Compared with previous studies, we add a second-order shaping term in the guild magnetic field. Theoretical analyses and numerical calculations show that it can enhance the conversion efficiency in the low-gain limit. The case of the initial velocity spread of electrons satisfying the Gaussian distribution is also analysed numerically.

Efficiency enhancement of slow-wave electron-cyclotron maser by a second-order shaping of the magnetic field in the low-gain limit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Si-Jia; Zhang, Yu-Fei; Wang, Kang

Based on the anomalous Doppler effect, we put forward a proposal to enhance the conversion efficiency of the slow-wave electron cyclotron masers (ECM) under the resonance condition. Compared with previous studies, we add a second-order shaping term in the guild magnetic field. Theoretical analyses and numerical calculations show that it can enhance the conversion efficiency in the low-gain limit. The case of the initial velocity spread of electrons satisfying the Gaussian distribution is also analysed numerically.

Slow Wave Sleep and Long Duration Spaceflight

NASA Technical Reports Server (NTRS)

Orr, M.; Whitmire, A.; Arias, D.; Leveton, L.

2011-01-01

To review the literature on slow wave sleep (SWS) in long duration space flight, and place this within the context of the broader literature on SWS particularly with respect to analogous environments such as the Antarctic. Explore how SWS could be measured within the International Space Station (ISS) context with the aim to utilize the ISS as an analog for future extra-orbital long duration missions. Discuss the potential use of emergent minimally intrusive wireless technologies like ZEO for integrated prelaunch, flight, and return to Earth analysis and optimization of SWS (and general quality of sleep).

Slow-Wave Phase Shifters, Based on Thin Ferroelectric Films, for Reflectarray Antennas. Frequency-Agile Radio: Systems and Technlogies, WMG 139

NASA Technical Reports Server (NTRS)

Romanofsky, Robert R.

2006-01-01

We have developed relatively broadband K- and Ka-band phase shifters using synthetic (slow-wave) transmission lines employing coupled microstripline "varactors". The tunable coupled microstripline circuits are based on laser ablated BaSrTiO films on lanthanum aluminate substrates. A model and design criteria for these novel circuits will be presented, along with measured performance including anomalous phase delay characteristics. The critical role of phase shifter loss and transient response in reflectarray antennas will be emphasized.

Lower hybrid accessibility in a large, hot reversed field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dziubek, R.A.; Harvey, R.W.; Hokin, S.A.

1995-11-01

Accessibility and damping of the slow wave in a reversed field pinch (RFP) plasma is investigated theoretically, using projected Reversed Field Experiment (RFX) plasma parameters. By numerically solving the hot plasma dispersion relation, regions of propagation are found and the possibility of mode conversion is analyzed. If the parallel index of refraction of the wave is chosen judiciously at the edge of the plasma, the slow wave is accessible to a target region located just inside the reversal surface without mode conversion. Landau damping is also optimized in this region. A representative fast electron population is then added in ordermore » to determine its effect on accessibility and damping. The presence of these electrons, whose parameters were estimated by extrapolation of Madison Symmetric Torus (MST) data, does not affect the accessibility of the wave. However, the initial phase velocity of the wave needs to be increased somewhat in order to maintain optimal damping in the target zone.« less

The Fisher-KPP problem with doubly nonlinear diffusion

NASA Astrophysics Data System (ADS)

Audrito, Alessandro; Vázquez, Juan Luis

2017-12-01

The famous Fisher-KPP reaction-diffusion model combines linear diffusion with the typical KPP reaction term, and appears in a number of relevant applications in biology and chemistry. It is remarkable as a mathematical model since it possesses a family of travelling waves that describe the asymptotic behaviour of a large class solutions 0 ≤ u (x , t) ≤ 1 of the problem posed in the real line. The existence of propagation waves with finite speed has been confirmed in some related models and disproved in others. We investigate here the corresponding theory when the linear diffusion is replaced by the "slow" doubly nonlinear diffusion and we find travelling waves that represent the wave propagation of more general solutions even when we extend the study to several space dimensions. A similar study is performed in the critical case that we call "pseudo-linear", i.e., when the operator is still nonlinear but has homogeneity one. With respect to the classical model and the "pseudo-linear" case, the "slow" travelling waves exhibit free boundaries.

The Parametric Decay Instability of Alfvén Waves in Turbulent Plasmas and the Applications in the Solar Wind

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shi, Mijie; Xiao, Chijie; Wang, Xiaogang

2017-06-10

We perform three-dimensional ideal magnetohydrodynamic (MHD) simulations to study the parametric decay instability (PDI) of Alfvén waves in turbulent plasmas and explore its possible applications in the solar wind. We find that, over a broad range of parameters in background turbulence amplitudes, the PDI of an Alfvén wave with various amplitudes can still occur, though its growth rate in turbulent plasmas tends to be lower than both the theoretical linear theory prediction and that in the non-turbulent situations. Spatial–temporal FFT analyses of density fluctuations produced by the PDI match well with the dispersion relation of the slow MHD waves. Thismore » result may provide an explanation of the generation mechanism of slow waves in the solar wind observed at 1 au. It further highlights the need to explore the effects of density variations in modifying the turbulence properties as well as in heating the solar wind plasmas.« less

Influence of viscoelastic property on laser-generated surface acoustic waves in coating-substrate systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun Hongxiang; Faculty of Science, Jiangsu University, Zhenjiang 212013; Zhang Shuyi

2011-04-01

Taking account of the viscoelasticity of materials, the pulsed laser generation of surface acoustic waves in coating-substrate systems has been investigated quantitatively by using the finite element method. The displacement spectra of the surface acoustic waves have been calculated in frequency domain for different coating-substrate systems, in which the viscoelastic properties of the coatings and substrates are considered separately. Meanwhile, the temporal displacement waveforms have been obtained by applying inverse fast Fourier transforms. The numerical results of the normal surface displacements are presented for different configurations: a single plate, a slow coating on a fast substrate, and a fast coatingmore » on a slow substrate. The influences of the viscoelastic properties of the coating and the substrate on the attenuation of the surface acoustic waves have been studied. In addition, the influence of the coating thickness on the attenuation of the surface acoustic waves has been also investigated in detail.« less

The dissipation of electromagnetic waves in plasmas

NASA Astrophysics Data System (ADS)

Basov, N. G.

The present anthology includes articles concerning the experimental study of the interaction of high power electromagnetic waves with collisionless plasmas and with electrons. Among the topics covered are the nonlinear dissipation of electromagnetic waves in inhomogeneous collisionless plasmas, the collisionless absorption of electromagnetic waves in plasmas and 'slow' nonlinear phenomena, the nonlinear effects of electron plasma waves propagating in an inhomogeneous plasma layer, and secondary-emission microwave discharges having large electron transit angles.

Non-REM sleep EEG power distribution in fatigue and sleepiness.

PubMed

Neu, Daniel; Mairesse, Olivier; Verbanck, Paul; Linkowski, Paul; Le Bon, Olivier

2014-04-01

The aim of this study is to contribute to the sleep-related differentiation between daytime fatigue and sleepiness. 135 subjects presenting with sleep apnea-hypopnea syndrome (SAHS, n=58) or chronic fatigue syndrome (CFS, n=52) with respective sleepiness or fatigue complaints and a control group (n=25) underwent polysomnography and psychometric assessments for fatigue, sleepiness, affective symptoms and perceived sleep quality. Sleep EEG spectral analysis for ultra slow, delta, theta, alpha, sigma and beta power bands was performed on frontal, central and occipital derivations. Patient groups presented with impaired subjective sleep quality and higher affective symptom intensity. CFS patients presented with highest fatigue and SAHS patients with highest sleepiness levels. All groups showed similar total sleep time. Subject groups mainly differed in sleep efficiency, wake after sleep onset, duration of light sleep (N1, N2) and slow wave sleep, as well as in sleep fragmentation and respiratory disturbance. Relative non-REM sleep power spectra distributions suggest a pattern of power exchange in higher frequency bands at the expense of central ultra slow power in CFS patients during all non-REM stages. In SAHS patients, however, we found an opposite pattern at occipital sites during N1 and N2. Slow wave activity presents as a crossroad of fatigue and sleepiness with, however, different spectral power band distributions during non-REM sleep. The homeostatic function of sleep might be compromised in CFS patients and could explain why, in contrast to sleepiness, fatigue does not resolve with sleep in these patients. The present findings thus contribute to the differentiation of both phenomena. Copyright © 2014 Elsevier Inc. All rights reserved.

Seismic Study of Tremor, Deep Long-Period Earthquakes, and Basin Amplification of Ground Motion

NASA Astrophysics Data System (ADS)

Han, Jiangang

In this thesis, we use seismic data and seismological tools to investigate three topics, (1) triggering between slow slip (tremor as proxy) and nearby small earthquakes, (2) mechanisms of deep-long period earthquakes beneath Mount St. Helens, and (3) ground motion amplification in Seattle Basin. In Chapter 1, we investigate 12-year earthquake and tremor catalogs for southwest Japan, and find nearby small intraslab earthquakes are weakly correlated with tremor. In particular, intraslab earthquakes tend to be followed by tremor more often than expected at random, while the excess number of tremor before earthquakes is not as significant. The underlying triggering mechanism of tremor and inferred slow slip by earthquakes is most likely to be the dynamic stress changes (several to several tens of kPa) rather than the much smaller static stress changes. In Chapter 2, we use the catalog DLPs as templates to search for repeating events at Mount St. Helens (MSH). We have detected 277 DLPs, compared to only 22 events previously in the catalog from 2007 to 2016. Three templates from the catalog are single events, while all other templates produced matches, identifying loci of repeated activity. Overall, the detected DLPs show no significant correlation with either the subduction zone tremor and slow slip (ETS) west of MSH, or the shallow seismicity. Temporal analysis shows an elevated rate of DLPs at time of compressional tidal stress, suggesting their possible association with magmatic and/or fluid activity. We observed variable S wave polarization of the DLPs from the most productive DLP source region, indicating their source mechanisms are not identical. In Chapter 3, we use noise correlation to retrieve the empirical green's functions (EGFs) in Seattle Basin. Consistent amplitudes measured from noise EGFs, teleseismic S wave and numerical simulations all suggest the usefulness of the amplitude of EGFs. For surface wave with period of 5-10 sec propagating from west to east, the ground motion is amplified by a factor of up to 3 within the basin. The bias of EGFs from noise heterogeneity and uncertainties of synthetics due to inaccuracy of velocity model are still to be investigated.

Shelf width and river base level on active margins controlled by a combination of eustasy and local uplift rate, illustration from the Pacific NW of the United States.

NASA Astrophysics Data System (ADS)

Malatesta, L. C.; Finnegan, N. J.; Kushwaha, G.

2017-12-01

Sea level defines the elevation where wave-base erosion is the dominant erosive process. Hence, submarine erosion of the margin and creation of a continental shelf depend on the time distribution of sea level relative to bedrock by correcting eustasy for local rock uplift. Eustasy and wave-base erosion also impact most fluvial systems on Earth by affecting the vertical and lateral position of their lower boundary condition, the coastline. When uplift rate is slow, the concentration of wave-base erosion on a restricted range of elevation promotes the creation of wide shelves and of a relatively stable average base level for coastal rivers. While interfluves above the shelf are steep, fluvial valleys in slow uplift regions grade into the shelf and form estuaries that trap sediment at high stand. Alternatively, a fast coastal uplift rate distributes wave-base erosion over a wide range of bedrock elevations that are quickly uplifted above the eustatic range, preventing the beveling of a shelf and the establishment of a river profile equilibrated around an average sea-level. In that case, river base level is highly dependent on the gradient of the continental slope. We show that the width of the shelf is inversely correlated with the uplift rate along the Oregon and northern California coast. The extent of the shelf can be a valuable counterpart to (often absent) marine terraces that provides a record for coastline retreat, local uplift rate and river base level.

Seismic waves triggering slow slip event on the pressure gauge records in the Hikurangi subducting margin

NASA Astrophysics Data System (ADS)

Ito, Y.; Wallace, L. M.; Henrys, S. A.; Kaneko, Y.; Webb, S. C.; Muramoto, T.; Ohta, K.; Mochizuki, K.; Suzuki, S.; Kido, M.; Hino, R.

2017-12-01

The two M7-class earthquakes struck in New Zealand in 2016. One is the M7.1 Te Araroa earthquake on 1st September, and the other is the M7.8 Kaikoura earthquake on 14th November. The M7.1 earthquake struck offshore, following a sequence of the Hikurangi slow slip event on the northern Hikurangi Margin. The M7.8 Kaikoura earthquake has triggered a shallow slow slip event of northern Hikurangi subduction margin. We present seismic and tsunami waves radiated from two large earthquakes of M7.8 Kaikoura and M7.1 Te Araroa earthquakes in 2016 using a network of absolute pressure gauges (APG) deployed at the Hikurangi subduction margin offshore New Zealand. We deployed 5 APG on the accretionary wedge at the northen part of the Hikurangi margnin in June 2016 at the northern part of Hikurangi subducting margin, and were recovered in June 2015. The pressure gauge recorded data continuously for one year, with a logging interval of 1 or 2 s. Our processing of the APG data to identify seismic is a band pass filter with a range of 10-100 s is applied for seismic signals. We observed seismic waves radiated from both the M7.8 Kaikoura and M7.1 Te Araroa earthquakes. The pressure fluctuation more than 20 hPa from the arrivals of seismic waves was observed on two both earthquakes. It should be noted that marine pressure records are nearly equivalent to vertical acceleration measurements [Webb, 1998]. Specifically, on the M7.8 Kaikoura earthquake, the characteristic seismic signals with large amplitude more than 20 hPa lasting more than 300 s was observed on the all of four APGs. The long duration seismic waves with relatively large amplitude observed after the 7.8 Kaikoura earthquake would dynamically trigger the Hikurangi slow slip event; the dynamic triggering and characteristic seismic waves in the accretionary wedge has been predicted from a wave-field modeling using a 3D velocity model with a low-velocity sedimentary basin [Wallace et al., 2017].

Dehydration of subducting slow-spread oceanic lithosphere in the Lesser Antilles.

PubMed

Paulatto, Michele; Laigle, Mireille; Galve, Audrey; Charvis, Philippe; Sapin, Martine; Bayrakci, Gaye; Evain, Mikael; Kopp, Heidrun

2017-07-10

Subducting slabs carry water into the mantle and are a major gateway in the global geochemical water cycle. Fluid transport and release can be constrained with seismological data. Here we use joint active-source/local-earthquake seismic tomography to derive unprecedented constraints on multi-stage fluid release from subducting slow-spread oceanic lithosphere. We image the low P-wave velocity crustal layer on the slab top and show that it disappears beneath 60-100 km depth, marking the depth of dehydration metamorphism and eclogitization. Clustering of seismicity at 120-160 km depth suggests that the slab's mantle dehydrates beneath the volcanic arc, and may be the main source of fluids triggering arc magma generation. Lateral variations in seismic properties on the slab surface suggest that serpentinized peridotite exhumed in tectonized slow-spread crust near fracture zones may increase water transport to sub-arc depths. This results in heterogeneous water release and directly impacts earthquakes generation and mantle wedge dynamics.

Dehydration of subducting slow-spread oceanic lithosphere in the Lesser Antilles

PubMed Central

Paulatto, Michele; Laigle, Mireille; Galve, Audrey; Charvis, Philippe; Sapin, Martine; Bayrakci, Gaye; Evain, Mikael; Kopp, Heidrun

2017-01-01

Subducting slabs carry water into the mantle and are a major gateway in the global geochemical water cycle. Fluid transport and release can be constrained with seismological data. Here we use joint active-source/local-earthquake seismic tomography to derive unprecedented constraints on multi-stage fluid release from subducting slow-spread oceanic lithosphere. We image the low P-wave velocity crustal layer on the slab top and show that it disappears beneath 60–100 km depth, marking the depth of dehydration metamorphism and eclogitization. Clustering of seismicity at 120–160 km depth suggests that the slab’s mantle dehydrates beneath the volcanic arc, and may be the main source of fluids triggering arc magma generation. Lateral variations in seismic properties on the slab surface suggest that serpentinized peridotite exhumed in tectonized slow-spread crust near fracture zones may increase water transport to sub-arc depths. This results in heterogeneous water release and directly impacts earthquakes generation and mantle wedge dynamics. PMID:28691714

Origin of low-frequency (intraseasonal) oscillations in the tropical atmosphere. II - Structure and propagation of mobile wave-CISK modes and their modification by lower boundary forcings

NASA Technical Reports Server (NTRS)

Sui, Chung-Hsiung; Lau, Ka-Ming

1989-01-01

An improved treatment of diabatic heating due to moist convection is introduced into the dynamical model of Lau and Peng (1987) to study the origin of intraseasonal oscillations in the tropics. It is found that the periods of slow-moving wave-CISK disturbances in the tropical troposphere with fixed sea surface temperature vary from 20 to 50 days. The results suggest that heating in the lower troposphere may be important in slowing down the wave-CISK modes. Also, it is shown that the intraseasonal oscillation can propagate around the globe even when the associated deep convection is only confined over warm sea surface temperatures.

Irregular wave functions of a hydrogen atom in a uniform magnetic field

NASA Technical Reports Server (NTRS)

Wintgen, D.; Hoenig, A.

1989-01-01

The highly excited irregular wave functions of a hydrogen atom in a uniform magnetic field are investigated analytically, with wave function scarring by periodic orbits considered quantitatively. The results obtained confirm that the contributions of closed classical orbits to the spatial wave functions vanish in the semiclassical limit. Their disappearance, however, is slow. This discussion is illustrated by numerical examples.

Bright-dark rogue wave in mode-locked fibre laser (Conference Presentation)

NASA Astrophysics Data System (ADS)

Kbashi, Hani; Kolpakov, Stanislav; Martinez, Amós; Mou, Chengbo; Sergeyev, Sergey V.

2017-05-01

Bright-Dark Rogue Wave in Mode-Locked Fibre Laser Hani Kbashi1*, Amos Martinez1, S. A. Kolpakov1, Chengbo Mou, Alex Rozhin1, Sergey V. Sergeyev1 1Aston Institute of Photonic Technologies, School of Engineering and Applied Science Aston University, Birmingham, B4 7ET, UK kbashihj@aston.ac.uk , 0044 755 3534 388 Keywords: Optical rogue wave, Bright-Dark rogue wave, rogue wave, mode-locked fiber laser, polarization instability. Abstract: Rogue waves (RWs) are statistically rare localized waves with high amplitude that suddenly appear and disappear in oceans, water tanks, and optical systems [1]. The investigation of these events in optics, optical rogue waves, is of interest for both fundamental research and applied science. Recently, we have shown that the adjustment of the in-cavity birefringence and pump polarization leads to emerge optical RW events [2-4]. Here, we report the first experimental observation of vector bright-dark RWs in an erbium-doped stretched pulse mode-locked fiber laser. The change of induced in-cavity birefringence provides an opportunity to observe RW events at pump power is a little higher than the lasing threshold. Polarization instabilities in the laser cavity result in the coupling between two orthogonal linearly polarized components leading to the emergence of bright-dark RWs. The observed clusters belongs to the class of slow optical RWs because their lifetime is of order of a thousand of laser cavity roundtrip periods. References: 1. D. R. Solli, C. Ropers, P. Koonath,and B. Jalali, Optical rogue waves," Nature, 450, 1054-1057, 2007. 2. S. V. Sergeyev, S. A. Kolpakov, C. Mou, G. Jacobsen, S. Popov, and V. Kalashnikov, "Slow deterministic vector rogue waves," Proc. SPIE 9732, 97320K (2016). 3. S. A. Kolpakov, H. Kbashi, and S. V. Sergeyev, "Dynamics of vector rogue waves in a fiber laser with a ring cavity," Optica, 3, 8, 870, (2016). 5. S. Kolpakov, H. Kbashi, and S. Sergeyev, "Slow optical rogue waves in a unidirectional fiber laser," in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optical Society of America, 2016), paper JW2A.56.

Rapid high-amplitude circumferential slow wave propagation during normal gastric pacemaking and dysrhythmias

PubMed Central

O'Grady, Gregory; Du, Peng; Paskaranandavadivel, Nira; Angeli, Timothy R.; Lammers, Wim JEP; Asirvatham, Samuel J.; Windsor, John A.; Farrugia, Gianrico; Pullan, Andrew J.; Cheng, Leo K.

2012-01-01

Background Gastric slow waves propagate aborally as rings of excitation. Circumferential propagation does not normally occur, except at the pacemaker region. We hypothesized that: i) the unexplained high-velocity, high-amplitude activity associated with the pacemaker region is a consequence of circumferential propagation; ii) rapid, high-amplitude circumferential propagation emerges during gastric dysrhythmias; iii) the driving network conductance might switch between ICC-MP and circular ICC-IM during circumferential propagation; iv) extracellular amplitudes and velocities are correlated. Methods An experimental-theoretical study was performed. HR gastric mapping was performed in pigs during normal activation, pacing and dysrhythmia. Activation profiles, velocities and amplitudes were quantified. ICC pathways were theoretically evaluated in a bidomain model. Extracellular potentials were modelled as a function of membrane potentials. Key Results High-velocity, high-amplitude activation was only recorded in the pacemaker region when circumferential conduction occurred. Circumferential propagation accompanied dysrhythmia in 8/8 experiments, was faster than longitudinal propagation (8.9 vs 6.9 mm/s; p=0.004), and of higher amplitude (739 vs 528 μV; p=0.007). Simulations predicted that ICC-MP could be the driving network during longitudinal propagation, whereas during ectopic pacemaking, ICC-IM could outpace and activate ICC-MP in the circumferential axis. Experimental and modeling data demonstrated a linear relationship between velocities and amplitudes (p<0.001). Conclusions & Inferences The high-velocity and high-amplitude profile of the normal pacemaker region is due to localized circumferential propagation. Rapid circumferential propagation also emerges during a range of gastric dysrhythmias, elevating extracellular amplitudes and organizing transverse wavefronts. One possible explanation for these findings is bidirectional coupling between ICC-MP and circular ICC-IM networks. PMID:22709238

Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin/orexin neuronal activation before, during and after deprivation.

PubMed

Arthaud, Sebastien; Varin, Christophe; Gay, Nadine; Libourel, Paul-Antoine; Chauveau, Frederic; Fort, Patrice; Luppi, Pierre-Herve; Peyron, Christelle

2015-06-01

Studying paradoxical sleep homeostasis requires the specific and efficient deprivation of paradoxical sleep and the evaluation of the subsequent recovery period. With this aim, the small-platforms-over-water technique has been used extensively in rats, but only rare studies were conducted in mice, with no sleep data reported during deprivation. Mice are used increasingly with the emergence of transgenic mice and technologies such as optogenetics, raising the need for a reliable method to manipulate paradoxical sleep. To fulfil this need, we refined this deprivation method and analysed vigilance states thoroughly during the entire protocol. We also studied activation of hypocretin/orexin and melanin-concentrating hormone neurones using Fos immunohistochemistry to verify whether mechanisms regulating paradoxical sleep in mice are similar to those in rats. We showed that 48 h of deprivation was highly efficient, with a residual amount of paradoxical sleep of only 2.2%. Slow wave sleep and wake quantities were similar to baseline, except during the first 4 h of deprivation, where slow wave sleep was strongly reduced. After deprivation, we observed a 124% increase in paradoxical sleep quantities during the first hour of rebound. In addition, 34% of hypocretin/orexin neurones were activated during deprivation, whereas melanin-concentrated hormone neurones were activated only during paradoxical sleep rebound. Corticosterone level showed a twofold increase after deprivation and returned to baseline level after 4 h of recovery. In summary, a fairly selective deprivation and a significant rebound of paradoxical sleep can be obtained in mice using the small-platforms-over-water method. As in rats, rebound is accompanied by a selective activation of melanin-concentrating hormone neurones. © 2014 European Sleep Research Society.

Synaptic Mechanisms of Memory Consolidation during Sleep Slow Oscillations

PubMed Central

Wei, Yina; Krishnan, Giri P.

2016-01-01

Sleep is critical for regulation of synaptic efficacy, memories, and learning. However, the underlying mechanisms of how sleep rhythms contribute to consolidating memories acquired during wakefulness remain unclear. Here we studied the role of slow oscillations, 0.2–1 Hz rhythmic transitions between Up and Down states during stage 3/4 sleep, on dynamics of synaptic connectivity in the thalamocortical network model implementing spike-timing-dependent synaptic plasticity. We found that the spatiotemporal pattern of Up-state propagation determines the changes of synaptic strengths between neurons. Furthermore, an external input, mimicking hippocampal ripples, delivered to the cortical network results in input-specific changes of synaptic weights, which persisted after stimulation was removed. These synaptic changes promoted replay of specific firing sequences of the cortical neurons. Our study proposes a neuronal mechanism on how an interaction between hippocampal input, such as mediated by sharp wave-ripple events, cortical slow oscillations, and synaptic plasticity, may lead to consolidation of memories through preferential replay of cortical cell spike sequences during slow-wave sleep. SIGNIFICANCE STATEMENT Sleep is critical for memory and learning. Replay during sleep of temporally ordered spike sequences related to a recent experience was proposed to be a neuronal substrate of memory consolidation. However, specific mechanisms of replay or how spike sequence replay leads to synaptic changes that underlie memory consolidation are still poorly understood. Here we used a detailed computational model of the thalamocortical system to report that interaction between slow cortical oscillations and synaptic plasticity during deep sleep can underlie mapping hippocampal memory traces to persistent cortical representation. This study provided, for the first time, a mechanistic explanation of how slow-wave sleep may promote consolidation of recent memory events. PMID:27076422

Multi-scale analysis of compressible fluctuations in the solar wind

NASA Astrophysics Data System (ADS)

Roberts, Owen W.; Narita, Yasuhito; Escoubet, C.-Philippe

2018-01-01

Compressible plasma turbulence is investigated in the fast solar wind at proton kinetic scales by the combined use of electron density and magnetic field measurements. Both the scale-dependent cross-correlation (CC) and the reduced magnetic helicity (σm) are used in tandem to determine the properties of the compressible fluctuations at proton kinetic scales. At inertial scales the turbulence is hypothesised to contain a mixture of Alfvénic and slow waves, characterised by weak magnetic helicity and anti-correlation between magnetic field strength B and electron density ne. At proton kinetic scales the observations suggest that the fluctuations have stronger positive magnetic helicities as well as strong anti-correlations within the frequency range studied. These results are interpreted as being characteristic of either counter-propagating kinetic Alfvén wave packets or a mixture of anti-sunward kinetic Alfvén waves along with a component of kinetic slow waves.

Three-dimensional simulation of helix traveling-wave tube cold-test characteristics using MAFIA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kory, C.L.

1996-12-31

A critically important step in the traveling-wave tube (TWT) design process is the cold-testing of the slow-wave circuit for dispersion, beam interaction impedance and RF losses. Experimental cold-tests can be very time-consuming and expensive, thus limiting the freedom to examine numerous variations to the test circuit. This makes the need for computational methods crucial as they can lower cost, reduce tube development time and allow the freedom to introduce novel and improved designs. The cold-test parameters have been calculated for a C-Band Northrop-Grumman helix TWT slow-wave circuit using MAFIA, the three-dimensional electromagnetic finite-integration computer code. Measured and simulated cold-test datamore » for the Northrop-Grumman helix TWT including dispersion, impedance and attenuation will be presented. Close agreement between simulated and measured values of the dispersion, impedance and attenuation has been obtained.« less

Behavior of ectopic surface: effects of β-adrenergic stimulation and uncoupling

PubMed Central

Arutunyan, Ara; Pumir, Alain; Krinsky, Valentin; Swift, Luther; Sarvazyan, Narine

2011-01-01

By using both experimental and theoretical means, we have addressed the progression of ectopic activity from individual cardiac cells to a multicellular two-dimensional network. Experimental conditions that favor ectopic activity have been created by local perfusion of a small area of cardiomyocyte network (I-zone) with an isoproterenol-heptanol containing solution. The application of this solution initially slowed down and then fully blocked wave propagation inside the I-zone. After a brief lag period, ectopically active cells appeared in the I-zone, followed by evolution of the ectopic clusters into slowly propagating waves. The changing pattern of colliding and expanding ectopic waves confined to the I-zone persisted for as long as the isoproterenol-heptanol environment was present. On restoration of the control environment, the ectopic waves from the I-zone broke out into the surrounding network causing arrhythmias. The observed sequence of events was also modeled by FitzHugh-Nagumo equations and included a cell’s arrangement of two adjacent square regions of 20 × 20 cells. The control zone consisted of well-connected, excitable cells, and the I-zone was made of weakly coupled cells (heptanol effect), which became spontaneously active as time evolved (isoproterenol effect). The dynamic events in the system have been studied numerically with the use of a finite difference method. Together, our experimental and computational data have revealed that the combination of low coupling, increased excitability, and spatial heterogeneity can lead to the development of ectopic waves confined to the injured network. This transient condition appears to serve as an essential step for the ectopic activity to “mature” before escaping into the surrounding control network. PMID:12893638

Behavior of ectopic surface: effects of beta-adrenergic stimulation and uncoupling.

PubMed

Arutunyan, Ara; Pumir, Alain; Krinsky, Valentin; Swift, Luther; Sarvazyan, Narine

2003-12-01

By using both experimental and theoretical means, we have addressed the progression of ectopic activity from individual cardiac cells to a multicellular two-dimensional network. Experimental conditions that favor ectopic activity have been created by local perfusion of a small area of cardiomyocyte network (I-zone) with an isoproterenol-heptanol containing solution. The application of this solution initially slowed down and then fully blocked wave propagation inside the I-zone. After a brief lag period, ectopically active cells appeared in the I-zone, followed by evolution of the ectopic clusters into slowly propagating waves. The changing pattern of colliding and expanding ectopic waves confined to the I-zone persisted for as long as the isoproterenol-heptanol environment was present. On restoration of the control environment, the ectopic waves from the I-zone broke out into the surrounding network causing arrhythmias. The observed sequence of events was also modeled by FitzHugh-Nagumo equations and included a cell's arrangement of two adjacent square regions of 20 x 20 cells. The control zone consisted of well-connected, excitable cells, and the I-zone was made of weakly coupled cells (heptanol effect), which became spontaneously active as time evolved (isoproterenol effect). The dynamic events in the system have been studied numerically with the use of a finite difference method. Together, our experimental and computational data have revealed that the combination of low coupling, increased excitability, and spatial heterogeneity can lead to the development of ectopic waves confined to the injured network. This transient condition appears to serve as an essential step for the ectopic activity to "mature" before escaping into the surrounding control network.

Battling Fatigue in Aviation: Recent Advancements in Research and Practice

DTIC Science & Technology

2012-01-01

During both baseline assessment and recovery sleep after acute total sleep de- privation, those with the G/A genotype exhibited greater levels of...low-frequency delta activity during non-REM sleep and slow-wave sleep than did subjects with the G/ G genotype . Similar research has been reported by...Tam PY, Dinges DF. Controlled breaks as a fatigue coun- termeasure on the flight deck. Aviat Space Environ Med. 2002;73:654-664. 66. Angus RG

Validation of an Accurate Three-Dimensional Helical Slow-Wave Circuit Model

NASA Technical Reports Server (NTRS)

Kory, Carol L.

1997-01-01

The helical slow-wave circuit embodies a helical coil of rectangular tape supported in a metal barrel by dielectric support rods. Although the helix slow-wave circuit remains the mainstay of the traveling-wave tube (TWT) industry because of its exceptionally wide bandwidth, a full helical circuit, without significant dimensional approximations, has not been successfully modeled until now. Numerous attempts have been made to analyze the helical slow-wave circuit so that the performance could be accurately predicted without actually building it, but because of its complex geometry, many geometrical approximations became necessary rendering the previous models inaccurate. In the course of this research it has been demonstrated that using the simulation code, MAFIA, the helical structure can be modeled with actual tape width and thickness, dielectric support rod geometry and materials. To demonstrate the accuracy of the MAFIA model, the cold-test parameters including dispersion, on-axis interaction impedance and attenuation have been calculated for several helical TWT slow-wave circuits with a variety of support rod geometries including rectangular and T-shaped rods, as well as various support rod materials including isotropic, anisotropic and partially metal coated dielectrics. Compared with experimentally measured results, the agreement is excellent. With the accuracy of the MAFIA helical model validated, the code was used to investigate several conventional geometric approximations in an attempt to obtain the most computationally efficient model. Several simplifications were made to a standard model including replacing the helical tape with filaments, and replacing rectangular support rods with shapes conforming to the cylindrical coordinate system with effective permittivity. The approximate models are compared with the standard model in terms of cold-test characteristics and computational time. The model was also used to determine the sensitivity of various circuit parameters including typical manufacturing dimensional tolerances and support rod permittivity. By varying the circuit parameters of an accurate model using MAFIA, these sensitivities can be computed for manufacturing concerns, and design optimization previous to fabrication, thus eliminating the need for costly experimental iterations. Several variations were made to a standard helical circuit using MAFIA to investigate the effect that variations on helical tape and support rod width, metallized loading height and support rod permittivity, have on TWT cold-test characteristics.

Measuring Temperature-Dependent Propagating Disturbances in Coronal Fan Loops Using Multiple SDO-AIA Channels and Surfing Transform Technique

NASA Technical Reports Server (NTRS)

Uritskiy, Vadim M.; Davila, Joseph M.; Viall, Nicholeen M.; Ofman, Leon

2013-01-01

A set of co-aligned high resolution images from the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO) is used to investigate propagating disturbances (PDs) in warm fan loops at the periphery of a non-flaring active region NOAA AR 11082. To measure PD speeds at multiple coronal temperatures, a new data analysis methodology is proposed enabling quantitative description of sub visual coronal motions with low signal-to-noise ratios of the order of 0.1. The technique operates with a set of one-dimensional surfing signals extracted from position-timeplots of several AIA channels through a modified version of Radon transform. The signals are used to evaluate a two-dimensional power spectral density distribution in the frequency - velocity space which exhibits a resonance in the presence of quasi-periodic PDs. By applying this analysis to the same fan loop structures observed in several AIA channels, we found that the traveling velocity of PDs increases with the temperature of the coronal plasma following the square root dependence predicted for the slow mode magneto-acoustic wave which seems to be the dominating wave mode in the studied loop structures. This result extends recent observations by Kiddie et al. (2012) to a more general class of fan loop systems not associated with sunspots and demonstrating consistent slow mode activity in up to four AIA channels.

EEG spectral power density profiles during NREM sleep for gaboxadol and zolpidem in patients with primary insomnia.

PubMed

Lundahl, Jonas; Deacon, Steve; Maurice, Damien; Staner, Luc

2012-08-01

There is significant interest in the functional significance and the therapeutic value of slow-wave sleep (SWS)-enhancing drugs. A prerequisite for studies of the functional differences is characterization of the electroencephalography (EEG) spectra following treatment in relevant patients. We evaluate for the first time gaboxadol and zolpidem treatments in insomniac patients using power spectra analysis. We carried out two randomized, double-blind, crossover studies. Study 1, 38 patients received gaboxadol 10 mg and 20 mg and zolpidem 10 mg; study 2, 23 patients received gaboxadol 5 mg and 15 mg. Treatments were administered during two nights and compared with placebo. Gaboxadol 10, 15 and 20 mg enhanced slow-wave activity (SWA) and theta power. In 1 Hz bins gaboxadol 10 and 20 mg enhanced power up to 9 Hz. In study 2, 15 mg gaboxadol showed a similar effect pattern. Zolpidem suppressed theta and alpha power, and increased sigma power, with no effect on SWA. In the 1 Hz bins zolpidem suppressed power between 5-10 Hz. Gaboxadol dose-dependently increased SWA and theta power in insomniac patients. In contrast, zolpidem did not affect SWA, reduced theta and alpha activity and enhanced sigma power. EEG spectral power differences may be consequences of the different mechanisms of action for zolpidem and the SWS-enhancing agent, gaboxadol.

Resting EEG deficits in accused murderers with schizophrenia.

PubMed

Schug, Robert A; Yang, Yaling; Raine, Adrian; Han, Chenbo; Liu, Jianghong; Li, Liejia

2011-10-31

Empirical evidence continues to suggest a biologically distinct violent subtype of schizophrenia. The present study examined whether murderers with schizophrenia would demonstrate resting EEG deficits distinguishing them from both non-violent schizophrenia patients and murderers without schizophrenia. Resting EEG data were collected from five diagnostic groups (normal controls, non-murderers with schizophrenia, murderers with schizophrenia, murderers without schizophrenia, and murderers with psychiatric conditions other than schizophrenia) at a brain hospital in Nanjing, China. Murderers with schizophrenia were characterized by increased left-hemispheric fast-wave EEG activity relative to non-violent schizophrenia patients, while non-violent schizophrenia patients instead demonstrated increased diffuse slow-wave activity compared to all other groups. Results are discussed within the framework of a proposed left-hemispheric over-processing hypothesis specific to violent individuals with schizophrenia, involving left hemispheric hyperarousal deficits, which may lead to a homicidally violent schizophrenia outcome. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Seismic noise frequency dependent P and S wave sources

NASA Astrophysics Data System (ADS)

Stutzmann, E.; Schimmel, M.; Gualtieri, L.; Farra, V.; Ardhuin, F.

2013-12-01

Seismic noise in the period band 3-10 sec is generated in the oceans by the interaction of ocean waves. Noise signal is dominated by Rayleigh waves but body waves can be extracted using a beamforming approach. We select the TAPAS array deployed in South Spain between June 2008 and September 2009 and we use the vertical and horizontal components to extract noise P and S waves, respectively. Data are filtered in narrow frequency bands and we select beam azimuths and slownesses that correspond to the largest continuous sources per day. Our procedure automatically discard earthquakes which are localized during short time durations. Using this approach, we detect many more noise P-waves than S-waves. Source locations are determined by back-projecting the detected slowness/azimuth. P and S waves are generated in nearby areas and both source locations are frequency dependent. Long period sources are dominantly in the South Atlantic and Indian Ocean whereas shorter period sources are rather in the North Atlantic Ocean. We further show that the detected S-waves are dominantly Sv-waves. We model the observed body waves using an ocean wave model that takes into account all possible wave interactions including coastal reflection. We use the wave model to separate direct and multiply reflected phases for P and S waves respectively. We show that in the South Atlantic the complex source pattern can be explained by the existence of both coastal and pelagic sources whereas in the North Atlantic most body wave sources are pelagic. For each detected source, we determine the equivalent source magnitude which is compared to the model.

Ultrasonic inspection of studs (bolts) using dynamic predictive deconvolution and wave shaping.

PubMed

Suh, D M; Kim, W W; Chung, J G

1999-01-01

Bolt degradation has become a major issue in the nuclear industry since the 1980's. If small cracks in stud bolts are not detected early enough, they grow rapidly and cause catastrophic disasters. Their detection, despite its importance, is known to be a very difficult problem due to the complicated structures of the stud bolts. This paper presents a method of detecting and sizing a small crack in the root between two adjacent crests in threads. The key idea is from the fact that the mode-converted Rayleigh wave travels slowly down the face of the crack and turns from the intersection of the crack and the root of thread to the transducer. Thus, when a crack exists, a small delayed pulse due to the Rayleigh wave is detected between large regularly spaced pulses from the thread. The delay time is the same as the propagation delay time of the slow Rayleigh wave and is proportional to the site of the crack. To efficiently detect the slow Rayleigh wave, three methods based on digital signal processing are proposed: wave shaping, dynamic predictive deconvolution, and dynamic predictive deconvolution combined with wave shaping.

Morvan's syndrome and the sustained absence of all sleep rhythms for months or years: An hypothesis.

PubMed

Touzet, Claude

2016-09-01

Despite the predation costs, sleep is ubiquitous in the animal realm. Humans spend a third of their life sleeping, and the quality of sleep has been related to co-morbidity, Alzheimer disease, etc. Excessive wakefulness induces rapid changes in cognitive performances, and it is claimed that one could die of sleep deprivation as quickly as by absence of water. In this context, the fact that a few people are able to go without sleep for months, even years, without displaying any cognitive troubles requires explanations. Theories ascribing sleep to memory consolidation are unable to explain such observations. It is not the case of the theory of sleep as the hebbian reinforcement of the inhibitory synapses (ToS-HRIS). Hebbian learning (Long Term Depression - LTD) guarantees that an efficient inhibitory synapse will lose its efficiency just because it is efficient at avoiding the activation of the post-synaptic neuron. This erosion of the inhibition is replenished by hebbian learning (Long Term Potentiation - LTP) when pre and post-synaptic neurons are active together - which is exactly what happens with the travelling depolarization waves of the slow-wave sleep (SWS). The best documented cases of months-long insomnia are reports of patients with Morvan's syndrome. This syndrome has an autoimmune cause that impedes - among many things - the potassium channels of the post-synaptic neurons, increasing LTP and decreasing LTD. We hypothesize that the absence of inhibitory efficiency erosion during wakefulness (thanks to a decrease of inhibitory LTD) is the cause for an absence of slow-wave sleep (SWS), which results also in the absence of REM sleep. Copyright © 2016 Elsevier Ltd. All rights reserved.

Hotspots and Superswell Beneath Africa Inferred From Surface Wave Anisotropic Tomography.

NASA Astrophysics Data System (ADS)

Sebai, A.; Stutzmann, E.; Montagner, J.

2003-12-01

In order to study the interaction at depth between hotspots and lithosphere we present a new anisotropic S-wave tomographic model of Africa which is derived from Rayleigh and Love wave phase velocity measurements. The strongest negative anomaly corresponds to the Afar plume which is presently the most active area of Africa. This slow anomaly, visible down to the deepest inverted depth (400km), is associated with azimuthal anisotropy that is weak right beneath the Afar and whose direction at further distances is diverging around the plume. This is consistent with active upwelling beneath the Afar. The smaller hotspots of Tibesti, Darfur, Hoggar and Mt Cameroon have appeared in regions that had been weakened by Late Jurassic-Early Cretaceous (145 Ma) rifting of West and Central Africa. They are associated with slow velocities down to about 200km. The smaller amplitude of these anomalies with respect to the Afar area and their limited depth extent may indicate that these hotspots have their origin in the uppermost boundary layer between asthenosphere and lithosphere. Nevertheless, there may be a complex relationship at depths shallower than 150km between these hotspots and the Afar. The superswell, located in the southern part of Africa is characterized by a broad area of positive velocity anomaly visible down to 300km depth. The base of Kalahari craton ( ˜ 280 km) is evidently characterized by an increase of azimuthal anisotropy. The direction of azimuthal axis is roughly North-South that rotates at the longitude of the Eastern rift to move around the Afar. This may suggest a feeding of Victoria and Afar hotspots from the deep South African superplume.

A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning.

PubMed

Wang, Qixuan; Oh, Ji Won; Lee, Hye-Lim; Dhar, Anukriti; Peng, Tao; Ramos, Raul; Guerrero-Juarez, Christian Fernando; Wang, Xiaojie; Zhao, Ran; Cao, Xiaoling; Le, Jonathan; Fuentes, Melisa A; Jocoy, Shelby C; Rossi, Antoni R; Vu, Brian; Pham, Kim; Wang, Xiaoyang; Mali, Nanda Maya; Park, Jung Min; Choi, June-Hyug; Lee, Hyunsu; Legrand, Julien M D; Kandyba, Eve; Kim, Jung Chul; Kim, Moonkyu; Foley, John; Yu, Zhengquan; Kobielak, Krzysztof; Andersen, Bogi; Khosrotehrani, Kiarash; Nie, Qing; Plikus, Maksim V

2017-07-11

The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns. Ear skin behaves as a hyper-refractory domain with HFs in extended rest phase. Such hyper-refractivity relates to high levels of BMP ligands and WNT antagonists, in part expressed by ear-specific cartilage and muscle. Hair growth stops at the boundaries with hyper-refractory ears and anatomically discontinuous eyelids, generating wave-breaking effects. We posit that similar mechanisms for coupled regeneration with dominant activator, hyper-refractory, and wave-breaker regions can operate in other actively renewing organs.

PubMed Central

Rajotte, Paul

1964-01-01

The discovery of new dysleptic drugs has prompted the present review of these substances which influence neuropsychic activity. It is possible to divide dysleptics into two categories: under the first heading fall mescaline, LSD-25, psilocybine, adrenochrome, bufotenine and dimethyltryptamin; the other group includes Ditran, Butoxamine, WH-4849, and AHR-379. The place of Sernyl could not be ascertained and it might well constitute a class by itself. The mescaline type of reaction is mainly characterized by the induction of perceptual distortions without alteration of the state of consciousness, whereas the Ditran type reaction is one of confusion with postexperimental amnesia. Electroencephalographic recordings support this classification: lowering of amplitude, acceleration of rhythm and desynchronization were noted with the first group; and slowing of rhythm and slow waves similar to those seen during the onset of sleep, with the other group. PMID:14184040

Generation of Magnetohydrodynamic Waves in Low Solar Atmospheric Flux Tubes by Photospheric Motions

NASA Astrophysics Data System (ADS)

Mumford, S. J.; Fedun, V.; Erdélyi, R.

2015-01-01

Recent ground- and space-based observations reveal the presence of small-scale motions between convection cells in the solar photosphere. In these regions, small-scale magnetic flux tubes are generated via the interaction of granulation motion and the background magnetic field. This paper studies the effects of these motions on magnetohydrodynamic (MHD) wave excitation from broadband photospheric drivers. Numerical experiments of linear MHD wave propagation in a magnetic flux tube embedded in a realistic gravitationally stratified solar atmosphere between the photosphere and the low choromosphere (above β = 1) are performed. Horizontal and vertical velocity field drivers mimic granular buffeting and solar global oscillations. A uniform torsional driver as well as Archimedean and logarithmic spiral drivers mimic observed torsional motions in the solar photosphere. The results are analyzed using a novel method for extracting the parallel, perpendicular, and azimuthal components of the perturbations, which caters to both the linear and non-linear cases. Employing this method yields the identification of the wave modes excited in the numerical simulations and enables a comparison of excited modes via velocity perturbations and wave energy flux. The wave energy flux distribution is calculated to enable the quantification of the relative strengths of excited modes. The torsional drivers primarily excite Alfvén modes (≈60% of the total flux) with small contributions from the slow kink mode, and, for the logarithmic spiral driver, small amounts of slow sausage mode. The horizontal and vertical drivers primarily excite slow kink or fast sausage modes, respectively, with small variations dependent upon flux surface radius.

An integrated perspective of the continuum between earthquakes and slow-slip phenomena

USGS Publications Warehouse

Peng, Zhigang; Gomberg, Joan

2010-01-01

The discovery of slow-slip phenomena has revolutionized our understanding of how faults accommodate relative plate motions. Faults were previously thought to relieve stress either through continuous aseismic sliding, or as earthquakes resulting from instantaneous failure of locked faults. In contrast, slow-slip events proceed so slowly that slip is limited and only low-frequency (or no) seismic waves radiate. We find that slow-slip phenomena are not unique to the depths (tens of kilometres) of subduction zone plate interfaces. They occur on faults in many settings, at numerous scales and owing to various loading processes, including landslides and glaciers. Taken together, the observations indicate that slowly slipping fault surfaces relax most of the accrued stresses through aseismic slip. Aseismic motion can trigger more rapid slip elsewhere on the fault that is sufficiently fast to generate seismic waves. The resulting radiation has characteristics ranging from those indicative of slow but seismic slip, to those typical of earthquakes. The mode of seismic slip depends on the inherent characteristics of the fault, such as the frictional properties. Slow-slip events have previously been classified as a distinct mode of fault slip compared with that seen in earthquakes. We conclude that instead, slip modes span a continuum and are of common occurrence.

Relative arrival-time upper-mantle tomography and the elusive background mean

NASA Astrophysics Data System (ADS)

Bastow, Ian D.

2012-08-01

The interpretation of seismic tomographic images of upper-mantle seismic wave speed structure is often a matter of considerable debate because the observations can usually be explained by a range of hypotheses, including variable temperature, composition, anisotropy, and the presence of partial melt. An additional problem, often overlooked in tomographic studies using relative as opposed to absolute arrival-times, is the issue of the resulting velocity model's zero mean. In shield areas, for example, relative arrival-time analysis strips off a background mean velocity structure that is markedly fast compared to the global average. Conversely, in active areas, the background mean is often markedly slow compared to the global average. Appreciation of this issue is vital when interpreting seismic tomographic images: 'high' and 'low' velocity anomalies should not necessarily be interpreted, respectively, as 'fast' and 'slow' compared to 'normal mantle'. This issue has been discussed in the seismological literature in detail over the years, yet subsequent tomography studies have still fallen into the trap of mis-interpreting their velocity models. I highlight here some recent examples of this and provide a simple strategy to address the problem using constraints from a recent global tomographic model, and insights from catalogues of absolute traveltime anomalies. Consultation of such absolute measures of seismic wave speed should be routine during regional tomographic studies, if only for the benefit of the broader Earth Science community, who readily follow the red = hot and slow, blue = cold and fast rule of thumb when interpreting the images for themselves.

Coordinated Interaction between Hippocampal Sharp-Wave Ripples and Anterior Cingulate Unit Activity

PubMed Central

2016-01-01

Hippocampal–cortical interaction during sleep promotes transformation of memory for long-term storage in the cortex. In particular, hippocampal sharp-wave ripple-associated neural activation is important for this transformation during slow-wave sleep. The anterior cingulate cortex (ACC) has been shown to be crucial for expression and likely storage of long-term memory. However, little is known about how ACC activity is influenced by hippocampal ripple activity during sleep. We report here about coordinated interactions between hippocampal ripple activity and ACC neural firings. By recording from the ACC and hippocampal CA1 simultaneously in mice, we found that almost all ACC neurons showed increased activity before hippocampal ripple activity; moreover, a subpopulation (17%) displayed a further activation immediately after ripple activity. This postripple activation of ACC neurons correlated positively with ripple amplitude, and the same neurons were excited upon electrical stimulation of the CA1. Interestingly, the preripple activation of ACC neurons was present during the sleep state, but not during the awake state. These results suggest intimate interactions between hippocampal sharp-wave ripples and ACC neurons in a state-dependent manner. Importantly, sharp-wave ripples and associated activation appear to regulate activity of a small population of ACC neurons, a process that may play a critical role in memory consolidation. SIGNIFICANCE STATEMENT The hippocampus communicates with the cortex for memory transformation. Memories of previous experiences become less dependent on the hippocampus and increasingly dependent on cortical areas, such as the anterior cingulate cortex (ACC). However, little evidence is available to directly support this hippocampus-to-cortex information transduction hypothesis of memory consolidation. Here we show that a subpopulation of ACC neurons becomes active just after hippocampal ripple activity, and that electrical stimulation of the hippocampus excites the same ACC neurons. In addition, the majority of ACC neurons are activated just before ripple activity during the sleep state, but not during the awake state. These results provide evidence supporting the hypothesis of hippocampus-to-cortex information flow for memory consolidation as well as reciprocal interaction between the hippocampus and the cortex. PMID:27733616

Helicon wave coupling in KSTAR plasmas for off-axis current drive in high electron pressure plasmas

NASA Astrophysics Data System (ADS)

Wang, S. J.; Wi, H. H.; Kim, H. J.; Kim, J.; Jeong, J. H.; Kwak, J. G.

2017-04-01

A helicon wave current drive is proposed as an efficient off-axis current drive in the high electron β plasmas that are expected in fusion reactors. A high frequency helicon wave coupling was analyzed using the surface impedance at a plasma boundary. A slow wave coupling, which may compete with the helicon wave coupling at a frequency of 500 MHz, is estimated to be lower than the fast wave coupling by an order of magnitude in the KSTAR edge plasma density and in practical Faraday shield misalignment with the magnetic pitch. A traveling wave antenna, which is a two port combline antenna, was analyzed using a simplified lumped element model. The results show that the traveling wave antenna provides load resiliency because of its insensitivity to loading resistance, provided that the loading resistance at a radiating element is limited within a practical range. The combline antenna is attractive because it does not require a matching system and exhibits a high selectivity of parallel refractive index. Based on the analysis, a seven element combline antenna was fabricated and installed at an off-mid-plane offset of 30 cm from the mid-plane in KSTAR. The low power RF characteristics measured during several plasma discharges showed no evidence of slow wave coupling. This is consistent with the expectation made through the surface impedance analysis which predicted low slow wave coupling. The wave coupling to the plasma is easily controlled by a radial outer-gap control and gas puffing. No plasma confinement degradation was observed during the radial outer-gap control of up to 3 cm in H-mode discharges. In a ELMy plasmas, only a small reflection peak was observed during a very short portion of the ELM bursting period. If the number of radiating elements is increased for high power operation, then complete load resiliency can be expected. A very large coupling can be problematic for maintaining a parallel refractive index, although this issue can be mitigated by increasing the number of elements.

Prolonged enhancement of REM sleep produced by carbachol microinjection into the amygdala.

PubMed

Calvo, J M; Simón-Arceo, K; Fernández-Mas, R

1996-01-31

The effect on sleep organization of carbachol microinjected into different amygdaloid nuclei was analysed in 12 cats. Single carbachol doses of 8 micrograms in 0.50 microliter saline were delivered unilaterally or bilaterally into the central, basal, lateral or basolateral amygdaloid nucleus. Carbachol administration into the central nucleus induced a prolonged (5 days) enhancement of both REM sleep and its preceeding slow wave sleep episodes with PGO waves (sommeil phasique a ondes lentes, SPHOL), which was more pronounced following bilateral than unilateral carbachol administration. However, neither SPHOL nor REM sleep changes were produced by administration of carbachol into the other amygdaloid nuclei. We conclude that cholinergic activation of the central amygdaloid nucleus produces a long-term facilitation of REM sleep occurrence.

Low-Frequency Waves in Cold Three-Component Plasmas

NASA Astrophysics Data System (ADS)

Fu, Qiang; Tang, Ying; Zhao, Jinsong; Lu, Jianyong

2016-09-01

The dispersion relation and electromagnetic polarization of the plasma waves are comprehensively studied in cold electron, proton, and heavy charged particle plasmas. Three modes are classified as the fast, intermediate, and slow mode waves according to different phase velocities. When plasmas contain positively-charged particles, the fast and intermediate modes can interact at the small propagating angles, whereas the two modes are separate at the large propagating angles. The near-parallel intermediate and slow waves experience the linear polarization, circular polarization, and linear polarization again, with the increasing wave number. The wave number regime corresponding to the above circular polarization shrinks as the propagating angle increases. Moreover, the fast and intermediate modes cause the reverse change of the electromagnetic polarization at the special wave number. While the heavy particles carry the negative charges, the dispersion relations of the fast and intermediate modes are always separate, being independent of the propagating angles. Furthermore, this study gives new expressions of the three resonance frequencies corresponding to the highly-oblique propagation waves in the general three-component plasmas, and shows the dependence of the resonance frequencies on the propagating angle, the concentration of the heavy particle, and the mass ratio among different kinds of particles. supported by National Natural Science Foundation of China (Nos. 11303099, 41531071 and 41574158), and the Youth Innovation Promotion Association CAS

Avoided-Level-Crossing Spectroscopy with Dressed Matter Waves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eckardt, Andre; Holthaus, Martin

2008-12-12

We devise a method for probing resonances of macroscopic matter waves in shaken optical lattices by monitoring their response to slow parameter changes, and show that such resonances can be disabled by particular choices of the driving amplitude. The theoretical analysis of this scheme reveals far-reaching analogies between dressed atoms and time periodically forced matter waves.

Avoided-Level-Crossing Spectroscopy with Dressed Matter Waves

NASA Astrophysics Data System (ADS)

Eckardt, André; Holthaus, Martin

2008-12-01

We devise a method for probing resonances of macroscopic matter waves in shaken optical lattices by monitoring their response to slow parameter changes, and show that such resonances can be disabled by particular choices of the driving amplitude. The theoretical analysis of this scheme reveals far-reaching analogies between dressed atoms and time periodically forced matter waves.

Cisplatin-induced gastric dysrhythmia and emesis in dogs and possible role of gastric electrical stimulation.

PubMed

Yu, Xiaoyun; Yang, Jie; Hou, Xiaohua; Zhang, Kan; Qian, Wei; Chen, J D Z

2009-05-01

The aim of this study was to investigate the effect of cisplatin on gastric myoelectrical activity and the role of gastric electrical stimulation in the treatment of cisplatin-induced emesis in dogs. Seven dogs implanted with electrodes on the gastric serosa were used in a two-session study. Cisplatin was infused in both the control session and the gastric electrical stimulation session, and gastric electrical stimulation was applied in the gastric electrical stimulation session. Gastric slow waves and emesis, as well as behaviors suggestive of nausea, were recorded during each session. The results were as follows: (1) cisplatin induced vomiting and other symptoms and induced gastric dysrhythmia. The percentage of normal slow waves decreased significantly during the 2.5 h before vomiting (P=0.01) and the period of vomiting (P<0.001). (2) Gastric electrical stimulation reduced emesis and the symptoms score. The total score in the control session was higher than that in the gastric electrical stimulation session (P=0.02). However, gastric electrical stimulation had no effects on gastric dysrhythmia. It is concluded that cisplatin induces emesis and gastric dysrhythmia. Gastric electrical stimulation may play a role in relieving chemotherapy-induced emetic responses and deserves further investigation.

Activation of L-type calcium channels is required for gap junction-mediated intercellular calcium signaling in osteoblastic cells

NASA Technical Reports Server (NTRS)

Jorgensen, Niklas Rye; Teilmann, Stefan Cuoni; Henriksen, Zanne; Civitelli, Roberto; Sorensen, Ole Helmer; Steinberg, Thomas H.

2003-01-01

The propagation of mechanically induced intercellular calcium waves (ICW) among osteoblastic cells occurs both by activation of P2Y (purinergic) receptors by extracellular nucleotides, resulting in "fast" ICW, and by gap junctional communication in cells that express connexin43 (Cx43), resulting in "slow" ICW. Human osteoblastic cells transmit intercellular calcium signals by both of these mechanisms. In the current studies we have examined the mechanism of slow gap junction-dependent ICW in osteoblastic cells. In ROS rat osteoblastic cells, gap junction-dependent ICW were inhibited by removal of extracellular calcium, plasma membrane depolarization by high extracellular potassium, and the L-type voltage-operated calcium channel inhibitor, nifedipine. In contrast, all these treatments enhanced the spread of P2 receptor-mediated ICW in UMR rat osteoblastic cells. Using UMR cells transfected to express Cx43 (UMR/Cx43) we confirmed that nifedipine sensitivity of ICW required Cx43 expression. In human osteoblastic cells, gap junction-dependent ICW also required activation of L-type calcium channels and influx of extracellular calcium.

Do false belief and verb non-factivity share similar neural circuits?

PubMed

Chen, Lan; Cheung, Him; Szeto, Ching-Yee; Zhu, Zude; Wang, Suiping

2012-02-21

The present study investigates whether the complement falsity elicited by strong non-factive verbs and the false belief activated by a standard nonverbal false belief task produce similar electrophysiological activities in the brain. The hypothesis is based on the notion that both complement falsity and false belief involve decoupling a false mental representation from reality. Some previous studies have reported a behavioral correlation between children's false belief reasoning and interpretation of strong non-factive verbs together with their false complements, but a neural basis for this correlation has not been found. Our event-related potential (ERP) results with normal adults showed that both nonverbal false belief and strong non-factive verb comprehension elicited a negative late slow waveform divergence compared to their respective baselines. Although these slow waves due to the two types of stimuli had slightly different scalp distributions, both were regarded as reflecting primarily frontal activation. Such ERP similarity provides evidence for a common neural basis shared by nonverbal false belief reasoning and comprehension of strong non-factive verbs. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

EEG in children with spelling disabilities.

PubMed

Byring, R F; Salmi, T K; Sainio, K O; Orn, H P

1991-10-01

A total of 23 13-year-old boys with spelling disabilities and 21 matched controls were studied. EEG was recorded for visual and quantitative analysis, including FFT band powers and normalized slope descriptors (NSD). Visual analysis showed general excess of slow activity, as well as an excess of temporal slow wave activity in the index group. Quantitative analysis showed low alpha and beta powers, and low "activity" and high "complexity" (NSD) in parieto-occipital derivations in the index group. Quantitative EEG (qEEG) parameter ratios between temporal and parieto-occipital derivations were increased in the index group, implying a lack of spatial differentiation in these EEGs. In covariance analysis the qEEG parameter differences between the index group and controls were partly explained by the neurotic traits made evident in psychological tests. This implies that psychopathological artifacts should be considered in qEEG examinations of children with cognitive handicaps. Differences in anterior/posterior qEEG ratios were, however, little affected by any confounding factors. Thus these qEEG ratios seem potentially useful in clinical assessments of children with learning disabilities.

Fibrillatory conduction in branching atrial tissue--Insight from volumetric and monolayer computer models.

PubMed

Wieser, L; Fischer, G; Nowak, C N; Tilg, B

2007-05-01

Increased local load in branching atrial tissue (muscle fibers and bundle insertions) influences wave propagation during atrial fibrillation (AF). This computer model study reveals two principal phenomena: if the branching is distant from the driving rotor (>19 mm), the load causes local slowing of conduction or wavebreaks. If the driving rotor is close to the branching, the increased load causes first a slow drift of the rotor towards the branching. Finally, the rotor anchors, and a stable, repeatable pattern of activation can be observed. Variation of the bundle geometry from a cylindrical, volumetric structure to a flat strip of a comparable load in a monolayer model changed the local activation sequence in the proximity of the bundle. However, the global behavior and the basic effects are similar in all models. Wavebreaks in branching tissue contribute to the chaotic nature of AF (fibrillatory conduction). The stabilization (anchoring) of driving rotors by branching tissue might contribute to maintain sustained AF.

Effects of load and maintenance duration on the time course of information encoding and retrieval in working memory: from perceptual analysis to post-categorization processes.

PubMed

Pinal, Diego; Zurrón, Montserrat; Díaz, Fernando

2014-01-01

information encoding, maintenance, and retrieval; these are supported by brain activity in a network of frontal, parietal and temporal regions. Manipulation of WM load and duration of the maintenance period can modulate this activity. Although such modulations have been widely studied using the event-related potentials (ERP) technique, a precise description of the time course of brain activity during encoding and retrieval is still required. Here, we used this technique and principal component analysis to assess the time course of brain activity during encoding and retrieval in a delayed match to sample task. We also investigated the effects of memory load and duration of the maintenance period on ERP activity. Brain activity was similar during information encoding and retrieval and comprised six temporal factors, which closely matched the latency and scalp distribution of some ERP components: P1, N1, P2, N2, P300, and a slow wave. Changes in memory load modulated task performance and yielded variations in frontal lobe activation. Moreover, the P300 amplitude was smaller in the high than in the low load condition during encoding and retrieval. Conversely, the slow wave amplitude was higher in the high than in the low load condition during encoding, and the same was true for the N2 amplitude during retrieval. Thus, during encoding, memory load appears to modulate the processing resources for context updating and post-categorization processes, and during retrieval it modulates resources for stimulus classification and context updating. Besides, despite the lack of differences in task performance related to duration of the maintenance period, larger N2 amplitude and stronger activation of the left temporal lobe after long than after short maintenance periods were found during information retrieval. Thus, results regarding the duration of maintenance period were complex, and future work is required to test the time-based decay theory predictions.

Fan filters, the 3-D Radon transform, and image sequence analysis.

PubMed

Marzetta, T L

1994-01-01

This paper develops a theory for the application of fan filters to moving objects. In contrast to previous treatments of the subject based on the 3-D Fourier transform, simplicity and insight are achieved by using the 3-D Radon transform. With this point of view, the Radon transform decomposes the image sequence into a set of plane waves that are parameterized by a two-component slowness vector. Fan filtering is equivalent to a multiplication in the Radon transform domain by a slowness response function, followed by an inverse Radon transform. The plane wave representation of a moving object involves only a restricted set of slownesses such that the inner product of the plane wave slowness vector and the moving object velocity vector is equal to one. All of the complexity in the application of fan filters to image sequences results from the velocity-slowness mapping not being one-to-one; therefore, the filter response cannot be independently specified at all velocities. A key contribution of this paper is to elucidate both the power and the limitations of fan filtering in this new application. A potential application of 3-D fan filters is in the detection of moving targets in clutter and noise. For example, an appropriately designed fan filter can reject perfectly all moving objects whose speed, irrespective of heading, is less than a specified cut-off speed, with only minor attenuation of significantly faster objects. A simple geometric construction determines the response of the filter for speeds greater than the cut-off speed.

Experimental Observation of Fermi-Pasta-Ulam Recurrence in a Nonlinear Feedback Ring System

NASA Astrophysics Data System (ADS)

Wu, Mingzhong; Patton, Carl E.

2007-01-01

Fermi-Pasta-Ulam recurrence through soliton dynamics has been realized. The experiment used a magnetic film strip-based active feedback ring. At some ring gain level, a wide spin wave pulse is self-generated in the ring. As the pulse circulates, it separates into two envelop solitons with different speeds. When the fast soliton catches up and collides with the slow soliton, the initial wide pulse is perfectly reconstructed. The repetition of this process leads to periodic recurrences of the initial pulse.

The New Social Studies in Perspective: The Carnegie-Mellon Slow-Learner Project.

ERIC Educational Resources Information Center

Penna, Anthony N.

1995-01-01

Describes the origins, development, and products of the slow- learner social studies curriculum development project at Carnegie-Mellon University (Pennsylvania) in the late 1960s. Maintains that this project represented the last wave of curriculum projects to emerge from the national reform efforts following Sputnik. (CFR)

Slow, Fast and Mixed Compressible Modes near the Magnetopause

NASA Astrophysics Data System (ADS)

Scudder, J. D.; Maynard, N. C.; Burke, W. J.

2003-12-01

We motivate and illustrate a new technique to certify time variations, observed in spacecraft frame of reference, as compressible slow or fast magnetosonic waves. Like the Walén test for Alfvén waves, our method for identifying compressible modes requires no Galilean transformation. Unlike the Walén test, we use covariance techniques with magnetic field time series to select three special projections of B(t). The projections of magnetic fluctuations are associated with three, usually non-orthogonal, wavevectors that, in principle, contribute to the locally sampled density fluctuations. Wavevector directions ({\\hat k}(CoV)) are derived from eigenvectors of covariance matrices and mean field directions, Bo. Linear theory for compressible modes indicates that these projections are proportional to the density fluctuations. Regression techniques are then applied to observed density and magnetic field profiles to specify coefficients of proportionality. Signs of proportionality constants, connecting the three projections of δ B and δ ρ , determine whether the compressional modes are of the fast (+) or slow (-) type. Within a polytropic-closure framework, the proportionality between magnetic and density fluctuations can be computed by relating {\\hat k}, the polytropic index, γ , and the plasma β . Our certification program validates the direct interpretation of proportionality constants comparing their best-fit and error values with the directions of wavevectors required by the dispersion relation, {\\hat k}(Disp) inferred from experimental measurements of β and γ . Final certification requires that for each mode retained in the correlation, the scalar product of wavevectors determined through covariance and dispersion-relation analyses are approximately unity \\hat k (CoV)\\cdot \\hat k (Disp)≈ 1. This quality check is the compressible-mode analogue to slope-one tests in the Walén test expressed in Elsässer [1950] variables. By products of completed certification include the assignment of various portions of time-domain data streams to the compression or rarefaction phases of fast/slow modes structures, the directions of wave-power propagation in the plasma frame and relative to the magnetic field direction as well as their phase speeds with respect to the background plasma. These certifications also imply temporal trains of electric fields of the ambipolar type, including spatially varying E∥ (t), that may be the cause of some of the structured observations of E∥ that have recently been detected near the diffusion region. Along with Walén tests the new procedures enable surveys for the presence and roles of non-dispersive fast, intermediate, and slow MHD waves in geospace. Geophysical examples from the Polar satellite illustrate fast, slow and even admixtures of fast and slow magnetosonic waves retrieved through our analysis. On this experimental basis, we discuss the roles of compressible-mode structures in boundary layers associated with the magnetopause.

Integrated fiber-coupled launcher for slow plasmon-polariton waves.

PubMed

Della Valle, Giuseppe; Longhi, Stefano

2012-01-30

We propose and numerically demonstrate an integrated fiber-coupled launcher for slow surface plasmon-polaritons. The device is based on a novel plasmonic mode-converter providing efficient power transfer from the fast to the slow modes of a metallic nanostripe. Total coupling efficiency with standard single-mode fiber approaching 30% (including ohmic losses) has been numerically predicted for a 25-µm long gold-based device operating at 1.55 µm telecom wavelength.

Determination of the 8° discontinuity beneath the major tectonic units of Central Europe from regional seismicity in Europe and northern Africa

NASA Astrophysics Data System (ADS)

Nita, B.; Perchuc, E.; Thybo, H.; Maguire, P.; Denton, P.

2004-12-01

We evaluate the existence and the depth of the '8° discontinuity' beneath the Alpine orogen using the natural seismicity of Europe and northern Africa as well as events induced by mining activity. For this analysis, the regional events (1) must have epicenters further than 1000 km from the structure being imaged, and (2) the magnitude of body waves must be higher than 4.0 to obtain a favourable signal to noise ratio. The events satisfying the above conditions have epicentres in Algeria, Spain, Bulgaria, Greece and in the Lubin Copper Basin in Poland. The last region is characterised by high seismicity resulting from mining activity. We base our analysis on P-wave traveltime residuals compared to the general iasp91 model. The 8° discontinuity seems to be attributed to the observed P-wave traveltime delays at epicentral distances around 800 km. The analysis of events from the Lubin Coper Basin and the events from other regions mentioned above, gives P-wave delays of 3 s at the Alpine stations in comparison with stations in the Variscan areas to further north. We attribute this variation in travel time to the difference between 'fast' and 'slow' uppermost mantle structures in Europe.