Slower saccadic reading in Parkinson's disease.

PubMed

Jehangir, Naz; Yu, Caroline Yizhu; Song, Jeehey; Shariati, Mohammad Ali; Binder, Steven; Beyer, Jill; Santini, Veronica; Poston, Kathleen; Liao, Yaping Joyce

2018-01-01

Idiopathic Parkinson's Disease (PD) is characterized by degeneration of dopaminergic and other neurons, leading to motor and non-motor deficits. Abnormal eye movements in PD, including fixations, saccades, and convergence, are well described. However, saccadic reading, which requires serial and alternating saccades and fixations, is not well studied, despite its obvious impact on the quality of life. In this study, we assessed saccadic reading using variations of the King-Devick (KD) test, a rapid single digit number naming test, as a way to assess the ability to make serial left-to-right ocular motor movements necessary for reading. We recruited 42 treated PD patients and 80 age-matched controls and compared their reading times with a variety of measures, including age, duration of disease, Unified Parkinson's Disease Rating Scale (UPDRS), the National Eye Institute 25-Item Visual Functioning Questionnaire 25 (VFQ-25), and Montreal Cognitive assessment (MoCA) test. The subjects performed 4 trials of reading 120 single digit numbers aloud as fast as possible without making errors. In each trial, they read 3 pages (KD1, KD2, and KD3), and each page contained 40 numbers per page in 8 lines with 5 numbers/line. We found that PD patients read about 20% slower than controls on all tests (KD1, 2, and 3 tests) (p < 0.02), and both groups read irregularly spaced numbers slower than regularly spaced numbers. Having lines between numbers to guide reading (KD1 tests) did not impact reading time in both PD and controls, but increased visual crowding as a result of decreased spacing between numbers (KD3 tests) was associated with significantly slower reading times in both PD and control groups. Our study revealed that saccadic reading is slower in PD, but controls and PD patients are both impacted by visuospatial planning challenges posed by increased visual crowding and irregularity of number spacing. Reading time did not correlate with UPDRS or MoCA scores in PD patients but significantly correlated with age, duration of disease, and VFQ-25 scores. The presence of convergence insufficiency did not significantly correlate with reading time in PD patients, although on average there was slower reading time in those with convergence insufficiency by 8 s (p = 0.2613). We propose that a simple reading task using 120 single-digit numbers can be used as a screening tool in the clinical setting to assess functional ocular motor difficulties in Parkinson's disease that can have a profound impact on quality of life.

Stochastic processes on multiple scales: averaging, decimation and beyond

NASA Astrophysics Data System (ADS)

Bo, Stefano; Celani, Antonio

The recent advances in handling microscopic systems are increasingly motivating stochastic modeling in a large number of physical, chemical and biological phenomena. Relevant processes often take place on widely separated time scales. In order to simplify the description, one usually focuses on the slower degrees of freedom and only the average effect of the fast ones is retained. It is then fundamental to eliminate such fast variables in a controlled fashion, carefully accounting for their net effect on the slower dynamics. We shall present how this can be done by either decimating or coarse-graining the fast processes and discuss applications to physical, biological and chemical examples. With the same tools we will address the fate of functionals of the stochastic trajectories (such as residence times, counting statistics, fluxes, entropy production, etc.) upon elimination of the fast variables. In general, for functionals, such elimination can present additional difficulties. In some cases, it is not possible to express them in terms of the effective trajectories on the slow degrees of freedom but additional details of the fast processes must be retained. We will focus on such cases and show how naive procedures can lead to inconsistent results.

Scalable Preconditioners for Structure Preserving Discretizations of Maxwell Equations in First Order Form

DOE PAGES

Phillips, Edward Geoffrey; Shadid, John N.; Cyr, Eric C.

2018-05-01

Here, we report multiple physical time-scales can arise in electromagnetic simulations when dissipative effects are introduced through boundary conditions, when currents follow external time-scales, and when material parameters vary spatially. In such scenarios, the time-scales of interest may be much slower than the fastest time-scales supported by the Maxwell equations, therefore making implicit time integration an efficient approach. The use of implicit temporal discretizations results in linear systems in which fast time-scales, which severely constrain the stability of an explicit method, can manifest as so-called stiff modes. This study proposes a new block preconditioner for structure preserving (also termed physicsmore » compatible) discretizations of the Maxwell equations in first order form. The intent of the preconditioner is to enable the efficient solution of multiple-time-scale Maxwell type systems. An additional benefit of the developed preconditioner is that it requires only a traditional multigrid method for its subsolves and compares well against alternative approaches that rely on specialized edge-based multigrid routines that may not be readily available. Lastly, results demonstrate parallel scalability at large electromagnetic wave CFL numbers on a variety of test problems.« less

Scalable Preconditioners for Structure Preserving Discretizations of Maxwell Equations in First Order Form

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, Edward Geoffrey; Shadid, John N.; Cyr, Eric C.

Here, we report multiple physical time-scales can arise in electromagnetic simulations when dissipative effects are introduced through boundary conditions, when currents follow external time-scales, and when material parameters vary spatially. In such scenarios, the time-scales of interest may be much slower than the fastest time-scales supported by the Maxwell equations, therefore making implicit time integration an efficient approach. The use of implicit temporal discretizations results in linear systems in which fast time-scales, which severely constrain the stability of an explicit method, can manifest as so-called stiff modes. This study proposes a new block preconditioner for structure preserving (also termed physicsmore » compatible) discretizations of the Maxwell equations in first order form. The intent of the preconditioner is to enable the efficient solution of multiple-time-scale Maxwell type systems. An additional benefit of the developed preconditioner is that it requires only a traditional multigrid method for its subsolves and compares well against alternative approaches that rely on specialized edge-based multigrid routines that may not be readily available. Lastly, results demonstrate parallel scalability at large electromagnetic wave CFL numbers on a variety of test problems.« less

Neuropsychological profiles of adolescents with ADHD: effects of reading difficulties and gender.

PubMed

Rucklidge, Julia J; Tannock, Rosemary

2002-11-01

Executive function, particularly behavioral inhibition, has been implicated as a core deficit specific to Attention-Deficit/Hyperactivity Disorder (ADHD) whereas rapid naming has been implicated as a core deficit specific to reading disabilities (RD). Females may be less impaired in executive function although adolescent females with ADHD have yet to be studied. Neuropsychological profiles of four adolescent groups aged 13-16 with equal female representation were investigated: 35 ADHD, 12 RD, 24 ADHD+RD, and 37 normal controls. A semi-structured interview (K-SADS-PL), the Conners Rating Scales and the Ontario Child Health Study Scales were used to diagnose ADHD. RD was defined as a standard score below 90 on at least one of the following: Reading or Spelling of the WRAT3 or Word Attack or Word Identification of the WRMT-R. The WISC-III, Rapid Automatized Naming, Stroop and Stop tasks were used as measures of cognitive and executive function. The two ADHD groups (ADHD, ADHD+RD) showed deficits in processing speed, naming of objects, poor behavioral inhibition and greater variability in reaction times whereas the two RD groups (RD, RD+ADHD) showed verbal working memory deficits and slower verbal retrieval speed. Only the comorbid group was slower with naming of numbers and colors and had slower reaction times. Regression analyses indicated that incongruent color naming (Stroop) and variability in go reaction time were the best predictors of hyperactive/impulsive ADHD symptoms whereas variability in go reaction time and processing speed were the best predictors of inattentive ADHD symptoms. Speed of letter naming and verbal working memory accounted for the most variability in composite achievement scores. No gender differences were found on any of the cognitive tests. This study challenges the importance of behavioral inhibition deficits in ADHD and that naming deficits are specific to RD. Further investigation into cognitive deficits in these groups is required.

Examining the Interplay of Processes Across Multiple Time-Scales: Illustration With the Intraindividual Study of Affect, Health, and Interpersonal Behavior (iSAHIB).

PubMed

Ram, Nilam; Conroy, David E; Pincus, Aaron L; Lorek, Amy; Rebar, Amanda; Roche, Michael J; Coccia, Michael; Morack, Jennifer; Feldman, Josh; Gerstorf, Denis

Human development is characterized by the complex interplay of processes that manifest at multiple levels of analysis and time-scales. We introduce the Intraindividual Study of Affect, Health and Interpersonal Behavior (iSAHIB) as a model for how multiple time-scale study designs facilitate more precise articulation of developmental theory. Combining age heterogeneity, longitudinal panel, daily diary, and experience sampling protocols, the study made use of smartphone and web-based technologies to obtain intensive longitudinal data from 150 persons age 18-89 years as they completed three 21-day measurement bursts ( t = 426 bursts, t = 8,557 days) wherein they provided reports on their social interactions ( t = 64,112) as they went about their daily lives. We illustrate how multiple time-scales of data can be used to articulate bioecological models of development and the interplay among more 'distal' processes that manifest at 'slower' time-scales (e.g., age-related differences and burst-to-burst changes in mental health) and more 'proximal' processes that manifest at 'faster' time-scales (e.g., changes in context that progress in accordance with the weekly calendar and family influence processes).

Asynchronously Coupled Models of Ice Loss from Airless Planetary Bodies

NASA Astrophysics Data System (ADS)

Schorghofer, N.

2016-12-01

Ice is found near the surface of dwarf planet Ceres, in some main belt asteroids, and perhaps in NEOs that will be explored or even mined in future. The simple but important question of how fast ice is lost from airless bodies can present computational challenges. The thermal cycle on the surface repeats on much shorter time-scales than ice retreats; one process acts on the time-scale of hours, the other over billions of years. This multi-scale situation is addressed with asynchronous coupling, where models with different time steps are woven together. The sharp contrast at the retreating ice table is dealt with with explicit interface tracking. For Ceres, which is covered with a thermally insulating dust mantle, desiccation rates are orders of magnitude slower than had been calculated with simpler models. More model challenges remain: The role of impact devolatization and the time-scale for complete desiccation of an asteroid. I will also share my experience with code distribution using GitHub and Zenodo.

Artificial dissipation and central difference schemes for the Euler and Navier-Stokes equations

NASA Technical Reports Server (NTRS)

Swanson, R. C.; Turkel, Eli

1987-01-01

An artificial dissipation model, including boundary treatment, that is employed in many central difference schemes for solving the Euler and Navier-Stokes equations is discussed. Modifications of this model such as the eigenvalue scaling suggested by upwind differencing are examined. Multistage time stepping schemes with and without a multigrid method are used to investigate the effects of changes in the dissipation model on accuracy and convergence. Improved accuracy for inviscid and viscous airfoil flow is obtained with the modified eigenvalue scaling. Slower convergence rates are experienced with the multigrid method using such scaling. The rate of convergence is improved by applying a dissipation scaling function that depends on mesh cell aspect ratio.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samu, Gergely F.; Janaky, Csaba; Kamat, Prashant V.

Photoinduced segregation in mixed halide perovskites has a direct influence on decreasing the solar cell efficiency as segregated I-rich domains serve as charge recombination centers. Here, the changes in the external quantum efficiency mirror the spectral loss in the absorption; however, the time scale of the IPCE recovery in the dark is slower than the absorption recovery, showing the intricate nature of the photoinduced halide segregation and charge collection in solar cell devices.

Dynamics of oxygen ordering in YBa2CU3O6+x studied by neutron and high-energy synchrotron x-ray diffiaction.

NASA Astrophysics Data System (ADS)

Frello, T.; Andersen, N. H.; Madsen, J.; Ka¨ll, M.; von Zimmermann, M.; Schmidt, O.; Poulsen, H. F.; Schneider, J. R.; Wolf, Th.

1997-08-01

The dynamics of the ortho-II oxygen structure in a high purity YBa 2Cu 3O 6+ x single crystal with x=0.50 has been studied by neutron and by X-ray diffraction with a photon energy of 100 keV. Our data show that the oxygen order develops on two different time-scales, one of the order of seconds and a much slower of the order of weeks and months. The mechanism dominating the slow time-scale is related to oxygen diffusion, while the fast mechanism may result from a temperature-dependent change in the average oxygen chain length.

Are there gender differences in cognitive function, chronic stress, and neurobehavioral symptoms after mild-to-moderate traumatic brain injury?

PubMed

Covassin, Tracey; Bay, Esther

2012-06-01

Research is inconclusive on whether gender differences exist in cognitive function in persons who sustain a mild-to-moderate traumatic brain injury (TBI). Furthermore, it is also unclear whether there is a relationship between chronic stress and cognitive function in these persons. The purpose of this integrative review is to determine whether gender differences exist in cognitive function, neurobehavioral symptoms, and chronic stress levels after a mild-to-moderate TBI. Participants (n = 72) were recruited from eight outpatient rehabilitation centers. Participants completed the demographic questions, the Immediate Postconcussion Assessment Cognitive Testing neurocognitive test battery, the Perceived Stress Scale-14, and the Neurobehavioral Functioning Inventory (NFI). Gender differences were present on verbal memory composite scores (p = .033), with women performing worse than men. There were no other between-gender differences on cognitive tasks, neurobehavioral symptoms, or chronic stress. Higher chronic stress levels result in a decrease in verbal memory (p = .015) and motor processing speed (p = .006) and slower reaction time (p = .007) for women. As male NFI cognition scores increased, motor processing speed scores decreased (p = .012) and reaction time got slower (p = .019), whereas women exhibited decreased verbal memory (p = .017) and slower reaction time (p = .034). As NFI motor symptoms increased, men exhibited decreased verbal memory (p = .005), visual memory (p = .002), and motor processing speed (p = .002) and slower reaction time (p = .002). Overall, this study only found gender differences on verbal memory composite scores, whereas the remaining cognitive tasks, neurobehavioral symptoms, and chronic stress did not indicate gender differences. Correlations between chronic stress, neurobehavioral symptoms, and cognitive function differed in both men and women with TBI. Persons in the chronic phase of recovery from a TBI may benefit from training in compensatory strategies for verbal memory deficits and stress management.

Longitudinal relationships among posturography and gait measures in multiple sclerosis.

PubMed

Fritz, Nora E; Newsome, Scott D; Eloyan, Ani; Marasigan, Rhul Evans R; Calabresi, Peter A; Zackowski, Kathleen M

2015-05-19

Gait and balance dysfunction frequently occurs early in the multiple sclerosis (MS) disease course. Hence, we sought to determine the longitudinal relationships among quantitative measures of gait and balance in individuals with MS. Fifty-seven ambulatory individuals with MS (28 relapsing-remitting, 29 progressive) were evaluated using posturography, quantitative sensorimotor and gait measures, and overall MS disability with the Expanded Disability Status Scale at each session. Our cohort's age was 45.8 ± 10.4 years (mean ± SD), follow-up time 32.8 ± 15.4 months, median Expanded Disability Status Scale score 3.5, and 56% were women. Poorer performance on balance measures was related to slower walking velocity. Two posturography measures, the anterior-posterior sway and sway during static eyes open, feet apart conditions, were significant contributors to walk velocity over time (approximate R(2) = 0.95), such that poorer performance on the posturography measures was related to slower walking velocity. Similarly, the anterior-posterior sway and sway during static eyes closed, feet together conditions were also significant contributors to the Timed 25-Foot Walk performance over time (approximate R(2) = 0.83). This longitudinal cohort study establishes a strong relationship between clinical gait measures and posturography. The data show that increases in static posturography and reductions in dynamic posturography are associated with a decline in walk velocity and Timed 25-Foot Walk performance over time. Furthermore, longitudinal balance measures predict future walking performance. Quantitative walking and balance measures are important additions to clinical testing to explore longitudinal change and understand fall risk in this progressive disease population. © 2015 American Academy of Neurology.

Multiple Scales of Representation along the Hippocampal Anteroposterior Axis in Humans.

PubMed

Brunec, Iva K; Bellana, Buddhika; Ozubko, Jason D; Man, Vincent; Robin, Jessica; Liu, Zhong-Xu; Grady, Cheryl; Rosenbaum, R Shayna; Winocur, Gordon; Barense, Morgan D; Moscovitch, Morris

2018-06-13

The ability to represent the world accurately relies on simultaneous coarse and fine-grained neural information coding, capturing both gist and detail of an experience. The longitudinal axis of the hippocampus may provide a gradient of representational granularity in spatial and episodic memory in rodents and humans [1-8]. Rodent place cells in the ventral hippocampus exhibit significantly larger place fields and greater autocorrelation than those in the dorsal hippocampus [1, 9-11], which may underlie a coarser and slower changing representation of space [10, 12]. Recent evidence suggests that properties of cellular dynamics in rodents can be captured with fMRI in humans during spatial navigation [13] and conceptual learning [14]. Similarly, mechanisms supporting granularity along the long axis may also be extrapolated to the scale of fMRI signal. Here, we provide the first evidence for separable scales of representation along the human hippocampal anteroposterior axis during navigation and rest by showing (1) greater similarity among voxel time courses and (2) higher temporal autocorrelation in anterior hippocampus (aHPC), relative to posterior hippocampus (pHPC), the human homologs of ventral and dorsal rodent hippocampus. aHPC voxels exhibited more similar activity at each time point and slower signal change over time than voxels in pHPC, consistent with place field organization in rodents. Importantly, similarity between voxels was related to navigational strategy and episodic memory. These findings provide evidence that the human hippocampus supports an anterior-to-posterior gradient of coarse-to-fine spatiotemporal representations, suggesting the existence of a cross-species mechanism, whereby lower neural similarity supports more complex coding of experience. Copyright © 2018 Elsevier Ltd. All rights reserved.

Aminopolymer Mobility and Support Interactions in Silica-PEI Composites for CO 2 Capture Applications: A Quasielastic Neutron Scattering Study

DOE PAGES

Holewinski, Adam; Sakwa-Novak, Miles A.; Carrillo, Jan-Michael Y.; ...

2017-05-30

Composite gas sorbents, formed from an active polymer phase and a porous support, are promising materials for the separation of acid gases from a variety of gas streams. Significant changes in sorption performance (capacity, rate, stability etc.) can be achieved by tuning the properties of the polymer and the nature of interactions between polymer and support. We utilize quasielastic neutron scattering (QENS) and coarse-grained molecular dynamics (MD) simulations to characterize the dynamic behavior of the most commonly reported polymer in such materials, poly(ethylenimine) (PEI), both in bulk form and when supported in a mesoporous silica framework. The polymer chain dynamicsmore » (rotational and translational diffusion) are characterized using two neutron backscattering spectrometers that have overlapping time scales, ranging from picoseconds to a few nanoseconds. Two modes of motion are detected for the PEI molecule in QENS. At low energy transfers, a “slow process” on the time scale of ~200 ps is found and attributed to jump-mediated, center-of-mass diffusion. Second, a “fast process” at ~20 ps scale is also found and is attributed to a locally confined, jump-diffusion. Characteristic data (time scale and spectral weight) of these processes are compared to those characterized by MD, and reasonable agreement is found. For the nanopore-confined PEI, we observe a significant reduction in the time scale of polymer motion as compared to the bulk. The impacts of silica surface functionalization and of polymer fill fraction in the silica pores (controlling the portion of polymer molecules in contact with the pore walls), are both studied in detail. Hydrophobic functionalization of the silica leads to an increase of the PEI mobility above that in native silanol-terminated silica, but the dynamics are still slower than those in bulk PEI. Sorbents with faster PEI dynamics are also found to be more efficient for CO 2 capture, possibly because sorption sites are more accessible than those in systems with slower PEI dynamics. Therefore, this work supports the existence of a link between the affinity of the support for PEI and the accessibility of active sorbent functional groups.« less

Spatial-pattern-induced evolution of a self-replicating loop network.

PubMed

Suzuki, Keisuke; Ikegami, Takashi

2006-01-01

We study a system of self-replicating loops in which interaction rules between individuals allow competition that leads to the formation of a hypercycle-like network. The main feature of the model is the multiple layers of interaction between loops, which lead to both global spatial patterns and local replication. The network of loops manifests itself as a spiral structure from which new kinds of self-replicating loops emerge at the boundaries between different species. In these regions, larger and more complex self-replicating loops live for longer periods of time, managing to self-replicate in spite of their slower replication. Of particular interest is how micro-scale interactions between replicators lead to macro-scale spatial pattern formation, and how these macro-scale patterns in turn perturb the micro-scale replication dynamics.

Multisensor data fusion across time and space

NASA Astrophysics Data System (ADS)

Villeneuve, Pierre V.; Beaven, Scott G.; Reed, Robert A.

2014-06-01

Field measurement campaigns typically deploy numerous sensors having different sampling characteristics for spatial, temporal, and spectral domains. Data analysis and exploitation is made more difficult and time consuming as the sample data grids between sensors do not align. This report summarizes our recent effort to demonstrate feasibility of a processing chain capable of "fusing" image data from multiple independent and asynchronous sensors into a form amenable to analysis and exploitation using commercially-available tools. Two important technical issues were addressed in this work: 1) Image spatial registration onto a common pixel grid, 2) Image temporal interpolation onto a common time base. The first step leverages existing image matching and registration algorithms. The second step relies upon a new and innovative use of optical flow algorithms to perform accurate temporal upsampling of slower frame rate imagery. Optical flow field vectors were first derived from high-frame rate, high-resolution imagery, and then finally used as a basis for temporal upsampling of the slower frame rate sensor's imagery. Optical flow field values are computed using a multi-scale image pyramid, thus allowing for more extreme object motion. This involves preprocessing imagery to varying resolution scales and initializing new vector flow estimates using that from the previous coarser-resolution image. Overall performance of this processing chain is demonstrated using sample data involving complex too motion observed by multiple sensors mounted to the same base. Multiple sensors were included, including a high-speed visible camera, up to a coarser resolution LWIR camera.

Multiscale skeletal representation of images via Voronoi diagrams

NASA Astrophysics Data System (ADS)

Marston, R. E.; Shih, Jian C.

1995-08-01

Polygonal approximations to skeletal or stroke-based representations of 2D objects may consume less storage and be sufficient to describe their shape for many applications. Multi- scale descriptions of object outlines are well established but corresponding methods for skeletal descriptions have been slower to develop. In this paper we offer a method of generating scale-based skeletal representation via the Voronoi diagram. The method has the advantages of less time complexity, a closer relationship between the skeletons at each scale and better control over simplification of the skeleton at lower scales. This is because the algorithm starts by generating the skeleton at the coarsest scale first, then it produces each finer scale, in an iterative manner, directly from the level below. The skeletal approximations produced by the algorithm also benefit from a strong relationship with the object outline, due to the structure of the Voronoi diagram.

Atomistic details of protein dynamics and the role of hydration water

DOE PAGES

Khodadadi, Sheila; Sokolov, Alexei P.

2016-05-04

The importance of protein dynamics for their biological activity is nowwell recognized. Different experimental and computational techniques have been employed to study protein dynamics, hierarchy of different processes and the coupling between protein and hydration water dynamics. But, understanding the atomistic details of protein dynamics and the role of hydration water remains rather limited. Based on overview of neutron scattering, molecular dynamic simulations, NMR and dielectric spectroscopy results we present a general picture of protein dynamics covering time scales from faster than ps to microseconds and the influence of hydration water on different relaxation processes. Internal protein dynamics spread overmore » a wide time range fromfaster than picosecond to longer than microseconds. We suggest that the structural relaxation in hydrated proteins appears on the microsecond time scale, while faster processes present mostly motion of side groups and some domains. Hydration water plays a crucial role in protein dynamics on all time scales. It controls the coupled protein-hydration water relaxation on 10 100 ps time scale. Our process defines the friction for slower protein dynamics. Analysis suggests that changes in amount of hydration water affect not only general friction, but also influence significantly the protein's energy landscape.« less

Atomistic details of protein dynamics and the role of hydration water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khodadadi, Sheila; Sokolov, Alexei P.

The importance of protein dynamics for their biological activity is nowwell recognized. Different experimental and computational techniques have been employed to study protein dynamics, hierarchy of different processes and the coupling between protein and hydration water dynamics. But, understanding the atomistic details of protein dynamics and the role of hydration water remains rather limited. Based on overview of neutron scattering, molecular dynamic simulations, NMR and dielectric spectroscopy results we present a general picture of protein dynamics covering time scales from faster than ps to microseconds and the influence of hydration water on different relaxation processes. Internal protein dynamics spread overmore » a wide time range fromfaster than picosecond to longer than microseconds. We suggest that the structural relaxation in hydrated proteins appears on the microsecond time scale, while faster processes present mostly motion of side groups and some domains. Hydration water plays a crucial role in protein dynamics on all time scales. It controls the coupled protein-hydration water relaxation on 10 100 ps time scale. Our process defines the friction for slower protein dynamics. Analysis suggests that changes in amount of hydration water affect not only general friction, but also influence significantly the protein's energy landscape.« less

Cognitive Reflection, Decision Biases, and Response Times

PubMed Central

Alós-Ferrer, Carlos; Garagnani, Michele; Hügelschäfer, Sabine

2016-01-01

We present novel evidence on response times and personality traits in standard questions from the decision-making literature where responses are relatively slow (medians around half a minute or above). To this end, we measured response times in a number of incentivized, framed items (decisions from description) including the Cognitive Reflection Test, two additional questions following the same logic, and a number of classic questions used to study decision biases in probability judgments (base-rate neglect, the conjunction fallacy, and the ratio bias). All questions create a conflict between an intuitive process and more deliberative thinking. For each item, we then created a non-conflict version by either making the intuitive impulse correct (resulting in an alignment question), shutting it down (creating a neutral question), or making it dominant (creating a heuristic question). For CRT questions, the differences in response times are as predicted by dual-process theories, with alignment and heuristic variants leading to faster responses and neutral questions to slower responses than the original, conflict questions. For decision biases (where responses are slower), evidence is mixed. To explore the possible influence of personality factors on both choices and response times, we used standard personality scales including the Rational-Experiential Inventory and the Big Five, and used them as controls in regression analysis. PMID:27713710

Cognitive Reflection, Decision Biases, and Response Times.

PubMed

Alós-Ferrer, Carlos; Garagnani, Michele; Hügelschäfer, Sabine

2016-01-01

We present novel evidence on response times and personality traits in standard questions from the decision-making literature where responses are relatively slow (medians around half a minute or above). To this end, we measured response times in a number of incentivized, framed items (decisions from description) including the Cognitive Reflection Test, two additional questions following the same logic, and a number of classic questions used to study decision biases in probability judgments (base-rate neglect, the conjunction fallacy, and the ratio bias). All questions create a conflict between an intuitive process and more deliberative thinking. For each item, we then created a non-conflict version by either making the intuitive impulse correct (resulting in an alignment question), shutting it down (creating a neutral question), or making it dominant (creating a heuristic question). For CRT questions, the differences in response times are as predicted by dual-process theories, with alignment and heuristic variants leading to faster responses and neutral questions to slower responses than the original, conflict questions. For decision biases (where responses are slower), evidence is mixed. To explore the possible influence of personality factors on both choices and response times, we used standard personality scales including the Rational-Experiential Inventory and the Big Five, and used them as controls in regression analysis.

Hierarchical coarse-graining model for photosystem II including electron and excitation-energy transfer processes.

PubMed

Matsuoka, Takeshi; Tanaka, Shigenori; Ebina, Kuniyoshi

2014-03-01

We propose a hierarchical reduction scheme to cope with coupled rate equations that describe the dynamics of multi-time-scale photosynthetic reactions. To numerically solve nonlinear dynamical equations containing a wide temporal range of rate constants, we first study a prototypical three-variable model. Using a separation of the time scale of rate constants combined with identified slow variables as (quasi-)conserved quantities in the fast process, we achieve a coarse-graining of the dynamical equations reduced to those at a slower time scale. By iteratively employing this reduction method, the coarse-graining of broadly multi-scale dynamical equations can be performed in a hierarchical manner. We then apply this scheme to the reaction dynamics analysis of a simplified model for an illuminated photosystem II, which involves many processes of electron and excitation-energy transfers with a wide range of rate constants. We thus confirm a good agreement between the coarse-grained and fully (finely) integrated results for the population dynamics. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Water Dynamics in Nafion Fuel Cell Membranes: the Effects of Confinement and Structural Changes on the Hydrogen Bond Network

PubMed Central

Moilanen, David E.; Piletic, Ivan R.; Fayer, Michael D.

2008-01-01

The complex environments experienced by water molecules in the hydrophilic channels of Nafion membranes are studied by ultrafast infrared pump-probe spectroscopy. A wavelength dependent study of the vibrational lifetime of the O-D stretch of dilute HOD in H2O confined in Nafion membranes provides evidence of two distinct ensembles of water molecules. While only two ensembles are present at each level of membrane hydration studied, the characteristics of the two ensembles change as the water content of the membrane changes. Time dependent anisotropy measurements show that the orientational motions of water molecules in Nafion membranes are significantly slower than in bulk water and that lower hydration levels result in slower orientational relaxation. Initial wavelength dependent results for the anisotropy show no clear variation in the time scale for orientational motion across a broad range of frequencies. The anisotropy decay is analyzed using a model based on restricted orientational diffusion within a hydrogen bond configuration followed by total reorientation through jump diffusion. PMID:18728757

Rippling ultrafast dynamics of suspended 2D monolayers, graphene

PubMed Central

Hu, Jianbo; Vanacore, Giovanni M.; Cepellotti, Andrea; Marzari, Nicola; Zewail, Ahmed H.

2016-01-01

Here, using ultrafast electron crystallography (UEC), we report the observation of rippling dynamics in suspended monolayer graphene, the prototypical and most-studied 2D material. The high scattering cross-section for electron/matter interaction, the atomic-scale spatial resolution, and the ultrafast temporal resolution of UEC represent the key elements that make this technique a unique tool for the dynamic investigation of 2D materials, and nanostructures in general. We find that, at early time after the ultrafast optical excitation, graphene undergoes a lattice expansion on a time scale of 5 ps, which is due to the excitation of short-wavelength in-plane acoustic phonon modes that stretch the graphene plane. On a longer time scale, a slower thermal contraction with a time constant of 50 ps is observed and associated with the excitation of out-of-plane phonon modes, which drive the lattice toward thermal equilibrium with the well-known negative thermal expansion coefficient of graphene. From our results and first-principles lattice dynamics and out-of-equilibrium relaxation calculations, we quantitatively elucidate the deformation dynamics of the graphene unit cell. PMID:27791028

Rippling ultrafast dynamics of suspended 2D monolayers, graphene.

PubMed

Hu, Jianbo; Vanacore, Giovanni M; Cepellotti, Andrea; Marzari, Nicola; Zewail, Ahmed H

2016-10-25

Here, using ultrafast electron crystallography (UEC), we report the observation of rippling dynamics in suspended monolayer graphene, the prototypical and most-studied 2D material. The high scattering cross-section for electron/matter interaction, the atomic-scale spatial resolution, and the ultrafast temporal resolution of UEC represent the key elements that make this technique a unique tool for the dynamic investigation of 2D materials, and nanostructures in general. We find that, at early time after the ultrafast optical excitation, graphene undergoes a lattice expansion on a time scale of 5 ps, which is due to the excitation of short-wavelength in-plane acoustic phonon modes that stretch the graphene plane. On a longer time scale, a slower thermal contraction with a time constant of 50 ps is observed and associated with the excitation of out-of-plane phonon modes, which drive the lattice toward thermal equilibrium with the well-known negative thermal expansion coefficient of graphene. From our results and first-principles lattice dynamics and out-of-equilibrium relaxation calculations, we quantitatively elucidate the deformation dynamics of the graphene unit cell.

The Response of Ice Sheets to Climate Variability

NASA Astrophysics Data System (ADS)

Snow, K.; Goldberg, D. N.; Holland, P. R.; Jordan, J. R.; Arthern, R. J.; Jenkins, A.

2017-12-01

West Antarctic Ice Sheet loss is a significant contributor to sea level rise. While the ice loss is thought to be triggered by fluctuations in oceanic heat at the ice shelf bases, ice sheet response to ocean variability remains poorly understood. Using a synchronously coupled ice-ocean model permitting grounding line migration, this study evaluates the response of an ice sheet to periodic variations in ocean forcing. Resulting oscillations in grounded ice volume amplitude is shown to grow as a nonlinear function of ocean forcing period. This implies that slower oscillations in climatic forcing are disproportionately important to ice sheets. The ice shelf residence time offers a critical time scale, above which the ice response amplitude is a linear function of ocean forcing period and below which it is quadratic. These results highlight the sensitivity of West Antarctic ice streams to perturbations in heat fluxes occurring at decadal time scales.

Self-trapping of the amide I band in a peptide model crystal

NASA Astrophysics Data System (ADS)

Edler, J.; Hamm, P.

2002-08-01

A femtosecond pump-probe study of the peculiar amide I band of acetanilide, a molecular crystal with hydrogen bonded chains of peptide units, is presented. The almost perfect harmonicity of the 1666 cm-1 subpeak is related to significant delocalization of this state at low enough temperatures (93 K). The "anomalous" peak (1650 cm-1), on the other hand, is strongly anharmonic, and hence assigned to a self-trapped state. This assignment is in agreement with a more indirect previous work. With increasing temperature, thermal disorder localizes the 1666 cm-1 band (Anderson localization) and at the same time destroys the self-trapping mechanism. Both the self-trapped state and the delocalized state decay on a 2 ps time scale into states outside the spectral window of this study. The excitation energy reappears on a much slower 35 ps time scale in the form of an increased lattice temperature.

Picosecond molecular motions in bacteriorhodopsin from neutron scattering.

PubMed Central

Fitter, J; Lechner, R E; Dencher, N A

1997-01-01

The characteristics of internal molecular motions of bacteriorhodopsin in the purple membrane have been studied by quasielastic incoherent neutron scattering. Because of the quasihomogeneous distribution of hydrogen atoms in biological molecules, this technique enables one to study a wide variety of intramolecular motions, especially those occurring in the picosecond to nanosecond time scale. We performed measurements at different energy resolutions with samples at various hydration levels within a temperature range of 10-300 K. The analysis of the data revealed a dynamical transition at temperatures Td between 180 K and 220 K for all motions resolved at time scales ranging from 0.1 to a few hundred picoseconds. Whereas below Td the motions are purely vibrational, they are predominantly diffusive above Td, characterized by an enormously broad distribution of correlation times. The variation of the hydration level, on the other hand, mainly affects motions slower than a few picoseconds. PMID:9336208

A Victim of Halide Ion Segregation. How Light Soaking Affects Solar Cell Performance of Mixed Halide Lead Perovskites

DOE PAGES

Samu, Gergely F.; Janaky, Csaba; Kamat, Prashant V.

2017-07-24

Photoinduced segregation in mixed halide perovskites has a direct influence on decreasing the solar cell efficiency as segregated I-rich domains serve as charge recombination centers. Here, the changes in the external quantum efficiency mirror the spectral loss in the absorption; however, the time scale of the IPCE recovery in the dark is slower than the absorption recovery, showing the intricate nature of the photoinduced halide segregation and charge collection in solar cell devices.

Depth resolution and preferential sputtering in depth profiling of sharp interfaces

NASA Astrophysics Data System (ADS)

Hofmann, S.; Han, Y. S.; Wang, J. Y.

2017-07-01

The influence of preferential sputtering on depth resolution of sputter depth profiles is studied for different sputtering rates of the two components at an A/B interface. Surface concentration and intensity depth profiles on both the sputtering time scale (as measured) and the depth scale are obtained by calculations with an extended Mixing-Roughness-Information depth (MRI)-model. The results show a clear difference for the two extreme cases (a) preponderant roughness and (b) preponderant atomic mixing. In case (a), the interface width on the time scale (Δt(16-84%)) increases with preferential sputtering if the faster sputtering component is on top of the slower sputtering component, but the true resolution on the depth scale (Δz(16-84%)) stays constant. In case (b), the interface width on the time scale stays constant but the true resolution on the depth scale varies with preferential sputtering. For similar order of magnitude of the atomic mixing and the roughness parameters, a transition state between the two extremes is obtained. While the normalized intensity profile of SIMS represents that of the surface concentration, an additional broadening effect is encountered in XPS or AES by the influence of the mean electron escape depth which may even cause an additional matrix effect at the interface.

A physical mechanism of cancer heterogeneity

NASA Astrophysics Data System (ADS)

Chen, Cong; Wang, Jin

2016-02-01

We studied a core cancer gene regulatory network motif to uncover possible source of cancer heterogeneity from epigenetic sources. When the time scale of the protein regulation to the gene is faster compared to the protein synthesis and degradation (adiabatic regime), normal state, cancer state and an intermediate premalignant state emerge. Due to the epigenetics such as DNA methylation and histone remodification, the time scale of the protein regulation to the gene can be slower or comparable to the protein synthesis and degradation (non-adiabatic regime). In this case, many more states emerge as possible phenotype alternations. This gives the origin of the heterogeneity. The cancer heterogeneity is reflected from the emergence of more phenotypic states, larger protein concentration fluctuations, wider kinetic distributions and multiplicity of kinetic paths from normal to cancer state, higher energy cost per gene switching, and weaker stability.

Confinement, Desolvation, And Electrosorption Effects on the Diffusion of Ions in Nanoporous Carbon Electrodes

PubMed Central

2015-01-01

Supercapacitors are electrochemical devices which store energy by ion adsorption on the surface of a porous carbon. They are characterized by high power delivery. The use of nanoporous carbon to increase their energy density should not hinder their fast charging. However, the mechanisms for ion transport inside electrified nanopores remain largely unknown. Here we show that the diffusion is characterized by a hierarchy of time scales arising from ion confinement, solvation, and electrosorption effects. By combining electrochemistry experiments with molecular dynamics simulations, we determine the in-pore conductivities and diffusion coefficients and their variations with the applied potential. We show that the diffusion of the ions is slower by 1 order of magnitude compared to the bulk electrolyte. The desolvation of the ions occurs on much faster time scales than electrosorption. PMID:26369420

The Western Africa ebola virus disease epidemic exhibits both global exponential and local polynomial growth rates.

PubMed

Chowell, Gerardo; Viboud, Cécile; Hyman, James M; Simonsen, Lone

2015-01-21

While many infectious disease epidemics are initially characterized by an exponential growth in time, we show that district-level Ebola virus disease (EVD) outbreaks in West Africa follow slower polynomial-based growth kinetics over several generations of the disease. We analyzed epidemic growth patterns at three different spatial scales (regional, national, and subnational) of the Ebola virus disease epidemic in Guinea, Sierra Leone and Liberia by compiling publicly available weekly time series of reported EVD case numbers from the patient database available from the World Health Organization website for the period 05-Jan to 17-Dec 2014. We found significant differences in the growth patterns of EVD cases at the scale of the country, district, and other subnational administrative divisions. The national cumulative curves of EVD cases in Guinea, Sierra Leone, and Liberia show periods of approximate exponential growth. In contrast, local epidemics are asynchronous and exhibit slow growth patterns during 3 or more EVD generations, which can be better approximated by a polynomial than an exponential function. The slower than expected growth pattern of local EVD outbreaks could result from a variety of factors, including behavior changes, success of control interventions, or intrinsic features of the disease such as a high level of clustering. Quantifying the contribution of each of these factors could help refine estimates of final epidemic size and the relative impact of different mitigation efforts in current and future EVD outbreaks.

The Western Africa Ebola Virus Disease Epidemic Exhibits Both Global Exponential and Local Polynomial Growth Rates

PubMed Central

Chowell, Gerardo; Viboud, Cécile; Hyman, James M; Simonsen, Lone

2015-01-01

Background: While many infectious disease epidemics are initially characterized by an exponential growth in time, we show that district-level Ebola virus disease (EVD) outbreaks in West Africa follow slower polynomial-based growth kinetics over several generations of the disease. Methods: We analyzed epidemic growth patterns at three different spatial scales (regional, national, and subnational) of the Ebola virus disease epidemic in Guinea, Sierra Leone and Liberia by compiling publicly available weekly time series of reported EVD case numbers from the patient database available from the World Health Organization website for the period 05-Jan to 17-Dec 2014. Results: We found significant differences in the growth patterns of EVD cases at the scale of the country, district, and other subnational administrative divisions. The national cumulative curves of EVD cases in Guinea, Sierra Leone, and Liberia show periods of approximate exponential growth. In contrast, local epidemics are asynchronous and exhibit slow growth patterns during 3 or more EVD generations, which can be better approximated by a polynomial than an exponential function. Conclusions: The slower than expected growth pattern of local EVD outbreaks could result from a variety of factors, including behavior changes, success of control interventions, or intrinsic features of the disease such as a high level of clustering. Quantifying the contribution of each of these factors could help refine estimates of final epidemic size and the relative impact of different mitigation efforts in current and future EVD outbreaks. PMID:25685633

Multiple-scale stochastic processes: Decimation, averaging and beyond

NASA Astrophysics Data System (ADS)

Bo, Stefano; Celani, Antonio

2017-02-01

The recent experimental progresses in handling microscopic systems have allowed to probe them at levels where fluctuations are prominent, calling for stochastic modeling in a large number of physical, chemical and biological phenomena. This has provided fruitful applications for established stochastic methods and motivated further developments. These systems often involve processes taking place on widely separated time scales. For an efficient modeling one usually focuses on the slower degrees of freedom and it is of great importance to accurately eliminate the fast variables in a controlled fashion, carefully accounting for their net effect on the slower dynamics. This procedure in general requires to perform two different operations: decimation and coarse-graining. We introduce the asymptotic methods that form the basis of this procedure and discuss their application to a series of physical, biological and chemical examples. We then turn our attention to functionals of the stochastic trajectories such as residence times, counting statistics, fluxes, entropy production, etc. which have been increasingly studied in recent years. For such functionals, the elimination of the fast degrees of freedom can present additional difficulties and naive procedures can lead to blatantly inconsistent results. Homogenization techniques for functionals are less covered in the literature and we will pedagogically present them here, as natural extensions of the ones employed for the trajectories. We will also discuss recent applications of these techniques to the thermodynamics of small systems and their interpretation in terms of information-theoretic concepts.

Resonance-modulated wavelength scaling of high-order-harmonic generation from H2+

NASA Astrophysics Data System (ADS)

Wang, Baoning; He, Lixin; Wang, Feng; Yuan, Hua; Zhu, Xiaosong; Lan, Pengfei; Lu, Peixiang

2018-01-01

Wavelength scaling of high-order harmonic generation (HHG) in a non-Born-Oppenheimer treatment of H2+ is investigated by numerical simulations of the time-dependent Schrödinger equation. The results show that the decrease in the wavelength-dependent HHG yield is reduced compared to that in the fixed-nucleus approximation. This slower wavelength scaling is related to the charge-resonance-enhanced ionization effect, which considerably increases the ionization rate at longer driving laser wavelengths due to the relatively larger nuclear separation. In addition, we find an oscillation structure in the wavelength scaling of HHG from H2+. Upon decreasing the laser intensity or increasing the nuclear mass, the oscillation structure will shift towards a longer wavelength of the laser pulse. These results permit the generation of an efficient harmonic spectrum in the midinfrared regime by manipulating the nuclear dynamics of molecules.

Automatic activation of exercise and sedentary stereotypes.

PubMed

Berry, Tanya; Spence, John C

2009-09-01

We examined the automatic activation of "sedentary" and "exerciser" stereotypes using a social prime Stroop task. Results showed significantly slower response times between the exercise words and the exercise control words and between the sedentary words and the exercise control words when preceded by an attractive exerciser prime. Words preceded by a normal-weight exerciser prime showed significantly slower response times for sedentary words over sedentary control words and exercise words. An overweight sedentary prime resulted in significantly slower response times for sedentary words over exercise words and exercise control words. These results highlight the need for increased awareness of how active and sedentary lifestyles are portrayed in the media.

Ultrafast carrier dynamics in a GaN/Al 0.18Ga0.82N superlattice

NASA Astrophysics Data System (ADS)

Mahler, Felix; Tomm, Jens W.; Reimann, Klaus; Woerner, Michael; Elsaesser, Thomas; Flytzanis, Christos; Hoffmann, Veit; Weyers, Markus

2018-04-01

Relaxation processes of photoexcited carriers in a GaN /Al0.18Ga0.82N superlattice are studied in femtosecond spectrally resolved reflectivity measurements at ambient temperature. The transient reflectivity reveals electron trapping into defect states close to the conduction-band minimum with a 150-200 fs time constant, followed by few-picosecond carrier cooling. A second slower trapping process into a different manifold of defect states is observed on a time scale of approximately 10 ps. Our results establish the prominent role of structural defects and disorder for ultrafast carrier dynamics in nitride semiconductor structures.

Time-resolved spectroscopy using a chopper wheel as a fast shutter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Shicong; Wendt, Amy E.; Boffard, John B.

Widely available, small form-factor, fiber-coupled spectrometers typically have a minimum exposure time measured in milliseconds, and thus cannot be used directly for time-resolved measurements at the microsecond level. Spectroscopy at these faster time scales is typically done with an intensified charge coupled device (CCD) system where the image intensifier acts as a “fast” electronic shutter for the slower CCD array. In this paper, we describe simple modifications to a commercially available chopper wheel system to allow it to be used as a “fast” mechanical shutter for gating a fiber-coupled spectrometer to achieve microsecond-scale time-resolved optical measurements of a periodically pulsedmore » light source. With the chopper wheel synchronized to the pulsing of the light source, the time resolution can be set to a small fraction of the pulse period by using a chopper wheel with narrow slots separated by wide spokes. Different methods of synchronizing the chopper wheel and pulsing of the light sources are explored. The capability of the chopper wheel system is illustrated with time-resolved measurements of pulsed plasmas.« less

Vibrational dynamics of aqueous hydroxide solutions probed using broadband 2DIR spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mandal, Aritra; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Tokmakoff, Andrei, E-mail: tokmakoff@uchicago.edu

2015-11-21

We employed ultrafast transient absorption and broadband 2DIR spectroscopy to study the vibrational dynamics of aqueous hydroxide solutions by exciting the O–H stretch vibrations of the strongly hydrogen-bonded hydroxide solvation shell water and probing the continuum absorption of the solvated ion between 1500 and 3800 cm{sup −1}. We observe rapid vibrational relaxation processes on 150–250 fs time scales across the entire probed spectral region as well as slower vibrational dynamics on 1–2 ps time scales. Furthermore, the O–H stretch excitation loses its frequency memory in 180 fs, and vibrational energy exchange between bulk-like water vibrations and hydroxide-associated water vibrations occursmore » in ∼200 fs. The fast dynamics in this system originate in strong nonlinear coupling between intra- and intermolecular vibrations and are explained in terms of non-adiabatic vibrational relaxation. These measurements indicate that the vibrational dynamics of the aqueous hydroxide complex are faster than the time scales reported for long-range transport of protons in aqueous hydroxide solutions.« less

Time-Resolved Small-Angle X-ray Scattering Reveals Millisecond Transitions of a DNA Origami Switch.

PubMed

Bruetzel, Linda K; Walker, Philipp U; Gerling, Thomas; Dietz, Hendrik; Lipfert, Jan

2018-04-11

Self-assembled DNA structures enable creation of specific shapes at the nanometer-micrometer scale with molecular resolution. The construction of functional DNA assemblies will likely require dynamic structures that can undergo controllable conformational changes. DNA devices based on shape complementary stacking interactions have been demonstrated to undergo reversible conformational changes triggered by changes in ionic environment or temperature. An experimentally unexplored aspect is how quickly conformational transitions of large synthetic DNA origami structures can actually occur. Here, we use time-resolved small-angle X-ray scattering to monitor large-scale conformational transitions of a two-state DNA origami switch in free solution. We show that the DNA device switches from its open to its closed conformation upon addition of MgCl 2 in milliseconds, which is close to the theoretical diffusive speed limit. In contrast, measurements of the dimerization of DNA origami bricks reveal much slower and concentration-dependent assembly kinetics. DNA brick dimerization occurs on a time scale of minutes to hours suggesting that the kinetics depend on local concentration and molecular alignment.

Protein dynamics in a broad frequency range: Dielectric spectroscopy studies

DOE PAGES

Nakanishi, Masahiro; Sokolov, Alexei P.

2014-09-17

We present detailed dielectric spectroscopy studies of dynamics in two hydrated proteins, lysozyme and myoglobin. We emphasize the importance of explicit account for possible Maxwell-Wagner (MW) polarization effects in protein powder samples. Combining our data with earlier literature results, we demonstrate the existence of three major relaxation processes in globular proteins. To understand the mechanisms of these relaxations we involve literature data on neutron scattering, simulations and NMR studies. The faster process is ascribed to coupled protein-hydration water motions and has relaxation time similar to 10-50 Ps at room temperature. The intermediate process is similar to 10(2)-10(3) times slower thanmore » the faster process and might be strongly affected by MW polarizations. Based on the analysis of data obtained by different experimental techniques and simulations, we ascribe this process to large scale domain-like motions of proteins. The slowest observed process is similar to 10(6)-10(7) times slower than the faster process and has anomalously large dielectric amplitude Delta epsilon similar to 10(2)-10(4). The microscopic nature of this process is not clear, but it seems to be related to the glass transition of hydrated proteins. The presentedresults suggest a general classification of the relaxation processes in hydrated proteins. (c) 2014 Elsevier B.V. All rights reserved.« less

Spatio-Temporal Dynamics of Impulse Responses to Figure Motion in Optic Flow Neurons

PubMed Central

Lee, Yu-Jen; Jönsson, H. Olof; Nordström, Karin

2015-01-01

White noise techniques have been used widely to investigate sensory systems in both vertebrates and invertebrates. White noise stimuli are powerful in their ability to rapidly generate data that help the experimenter decipher the spatio-temporal dynamics of neural and behavioral responses. One type of white noise stimuli, maximal length shift register sequences (m-sequences), have recently become particularly popular for extracting response kernels in insect motion vision. We here use such m-sequences to extract the impulse responses to figure motion in hoverfly lobula plate tangential cells (LPTCs). Figure motion is behaviorally important and many visually guided animals orient towards salient features in the surround. We show that LPTCs respond robustly to figure motion in the receptive field. The impulse response is scaled down in amplitude when the figure size is reduced, but its time course remains unaltered. However, a low contrast stimulus generates a slower response with a significantly longer time-to-peak and half-width. Impulse responses in females have a slower time-to-peak than males, but are otherwise similar. Finally we show that the shapes of the impulse response to a figure and a widefield stimulus are very similar, suggesting that the figure response could be coded by the same input as the widefield response. PMID:25955416

Theoretical restrictions on longest implicit time scales in Markov state models of biomolecular dynamics

NASA Astrophysics Data System (ADS)

Sinitskiy, Anton V.; Pande, Vijay S.

2018-01-01

Markov state models (MSMs) have been widely used to analyze computer simulations of various biomolecular systems. They can capture conformational transitions much slower than an average or maximal length of a single molecular dynamics (MD) trajectory from the set of trajectories used to build the MSM. A rule of thumb claiming that the slowest implicit time scale captured by an MSM should be comparable by the order of magnitude to the aggregate duration of all MD trajectories used to build this MSM has been known in the field. However, this rule has never been formally proved. In this work, we present analytical results for the slowest time scale in several types of MSMs, supporting the above rule. We conclude that the slowest implicit time scale equals the product of the aggregate sampling and four factors that quantify: (1) how much statistics on the conformational transitions corresponding to the longest implicit time scale is available, (2) how good the sampling of the destination Markov state is, (3) the gain in statistics from using a sliding window for counting transitions between Markov states, and (4) a bias in the estimate of the implicit time scale arising from finite sampling of the conformational transitions. We demonstrate that in many practically important cases all these four factors are on the order of unity, and we analyze possible scenarios that could lead to their significant deviation from unity. Overall, we provide for the first time analytical results on the slowest time scales captured by MSMs. These results can guide further practical applications of MSMs to biomolecular dynamics and allow for higher computational efficiency of simulations.

Charge carrier dynamics in organic semiconductors and their donor-acceptor composites: Numerical modeling of time-resolved photocurrent

NASA Astrophysics Data System (ADS)

Johnson, Brian; Kendrick, Mark J.; Ostroverkhova, Oksana

2013-09-01

We present a model that describes nanosecond (ns) time-scale photocurrent dynamics in functionalized anthradithiophene (ADT) films and ADT-based donor-acceptor (D/A) composites. By fitting numerically simulated photocurrents to experimental data, we quantify contributions of multiple pathways of charge carrier photogeneration to the photocurrent, as well as extract parameters that characterize charge transport (CT) in organic films including charge carrier mobilities, trap densities, hole trap depth, and trapping and recombination rates. In pristine ADT films, simulations revealed two competing charge photogeneration pathways: fast, occurring on picosecond (ps) or sub-ps time scales with efficiencies below 10%, and slow, which proceeds at the time scale of tens of nanoseconds, with efficiencies of about 11%-12%, at the applied electric fields of 40-80 kV/cm. The relative contribution of these pathways to the photocurrent was electric field dependent, with the contribution of the fast process increasing with applied electric field. However, the total charge photogeneration efficiency was weakly electric field dependent exhibiting values of 14%-20% of the absorbed photons. The remaining 80%-86% of the photoexcitation did not contribute to charge carrier generation at these time scales. In ADT-based D/A composites with 2 wt.% acceptor concentration, an additional pathway of charge photogeneration that proceeds via CT exciton dissociation contributed to the total charge photogeneration. In the composite with the functionalized pentacene (Pn) acceptor, which exhibits strong exciplex emission from a tightly bound D/A CT exciton, the contribution of the CT state to charge generation was small, ˜8%-12% of the total number of photogenerated charge carriers, dependent on the electric field. In contrast, in the composite with PCBM acceptor, the CT state contributed about a half of all photogenerated charge carriers. In both D/A composites, the charge carrier mobilities were reduced and trap densities and average trap depths were increased, as compared to a pristine ADT donor film. A considerably slower recombination of free holes with trapped electrons was found in the composite with the PCBM acceptor, which led to slower decays of the transient photocurrent and considerably higher charge retention, as compared to a pristine ADT donor film and the composite with the functionalized Pn acceptor.

Gap Acceptance During Lane Changes by Large-Truck Drivers—An Image-Based Analysis

PubMed Central

Nobukawa, Kazutoshi; Bao, Shan; LeBlanc, David J.; Zhao, Ding; Peng, Huei; Pan, Christopher S.

2016-01-01

This paper presents an analysis of rearward gap acceptance characteristics of drivers of large trucks in highway lane change scenarios. The range between the vehicles was inferred from camera images using the estimated lane width obtained from the lane tracking camera as the reference. Six-hundred lane change events were acquired from a large-scale naturalistic driving data set. The kinematic variables from the image-based gap analysis were filtered by the weighted linear least squares in order to extrapolate them at the lane change time. In addition, the time-to-collision and required deceleration were computed, and potential safety threshold values are provided. The resulting range and range rate distributions showed directional discrepancies, i.e., in left lane changes, large trucks are often slower than other vehicles in the target lane, whereas they are usually faster in right lane changes. Video observations have confirmed that major motivations for changing lanes are different depending on the direction of move, i.e., moving to the left (faster) lane occurs due to a slower vehicle ahead or a merging vehicle on the right-hand side, whereas right lane changes are frequently made to return to the original lane after passing. PMID:26924947

Gap Acceptance During Lane Changes by Large-Truck Drivers-An Image-Based Analysis.

PubMed

Nobukawa, Kazutoshi; Bao, Shan; LeBlanc, David J; Zhao, Ding; Peng, Huei; Pan, Christopher S

2016-03-01

This paper presents an analysis of rearward gap acceptance characteristics of drivers of large trucks in highway lane change scenarios. The range between the vehicles was inferred from camera images using the estimated lane width obtained from the lane tracking camera as the reference. Six-hundred lane change events were acquired from a large-scale naturalistic driving data set. The kinematic variables from the image-based gap analysis were filtered by the weighted linear least squares in order to extrapolate them at the lane change time. In addition, the time-to-collision and required deceleration were computed, and potential safety threshold values are provided. The resulting range and range rate distributions showed directional discrepancies, i.e., in left lane changes, large trucks are often slower than other vehicles in the target lane, whereas they are usually faster in right lane changes. Video observations have confirmed that major motivations for changing lanes are different depending on the direction of move, i.e., moving to the left (faster) lane occurs due to a slower vehicle ahead or a merging vehicle on the right-hand side, whereas right lane changes are frequently made to return to the original lane after passing.

Towards a microchannel-based X-ray detector with two-dimensional spatial and time resolution and high dynamic range

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Bernhard W.; Mane, Anil U.; Elam, Jeffrey W.

X-ray detectors that combine two-dimensional spatial resolution with a high time resolution are needed in numerous applications of synchrotron radiation. Most detectors with this combination of capabilities are based on semiconductor technology and are therefore limited in size. Furthermore, the time resolution is often realised through rapid time-gating of the acquisition, followed by a slower readout. Here, a detector technology is realised based on relatively inexpensive microchannel plates that uses GHz waveform sampling for a millimeter-scale spatial resolution and better than 100 ps time resolution. The technology is capable of continuous streaming of time- and location-tagged events at rates greatermore » than 10 7events per cm 2. Time-gating can be used for improved dynamic range.« less

Hybrid model for simulation of plasma jet injection in tokamak

NASA Astrophysics Data System (ADS)

Galkin, Sergei A.; Bogatu, I. N.

2016-10-01

Hybrid kinetic model of plasma treats the ions as kinetic particles and the electrons as charge neutralizing massless fluid. The model is essentially applicable when most of the energy is concentrated in the ions rather than in the electrons, i.e. it is well suited for the high-density hyper-velocity C60 plasma jet. The hybrid model separates the slower ion time scale from the faster electron time scale, which becomes disregardable. That is why hybrid codes consistently outperform the traditional PIC codes in computational efficiency, still resolving kinetic ions effects. We discuss 2D hybrid model and code with exact energy conservation numerical algorithm and present some results of its application to simulation of C60 plasma jet penetration through tokamak-like magnetic barrier. We also examine the 3D model/code extension and its possible applications to tokamak and ionospheric plasmas. The work is supported in part by US DOE DE-SC0015776 Grant.

Non-translational Molecular Diffusive Motion on Two Different Time Scales in Alkane Nanoparticles

NASA Astrophysics Data System (ADS)

Wang, S.-K.; Bai, M.; Taub, H.; Mamontov, E.; Herwig, K. W.; Hansen, F. Y.; Copley, J. R. D.; Jenkins, T.; Tyagi, M.; Volkmann, U. G.

2009-03-01

Using quasielastic neutron scattering, we have investigated molecular diffusive motion in n-C32H66 nanoparticles whose structure and phase transitions have been studied previously.^2 The spectra reveal non-translational (dispersionless) diffusive motion occurring simultaneously on time scales of ˜1 ns and ˜40 ps. The onset of the faster motion occurs in the crystalline phase at least 15 K below the melting point and is tentatively identified with rotation about the long molecular axis. Similarly, we suggest that the slower motion involves molecular conformational changes whose onset appears to coincide with the abrupt transition to the bulk rotator phase about 3 K below melting. These two types of diffusive motion bear a strong resemblance to those observed previously in C24 monolayers adsorbed on a graphite surface.^3 ^2M. Bai et al., Europhys. Lett. 79, 26003 (2007). ^3F. Y. Hansen et al., Phys. Rev. Lett. 92, 046103 (2004)].

Decorrelation of the static and dynamic length scales in hard-sphere glass formers.

PubMed

Charbonneau, Patrick; Tarjus, Gilles

2013-04-01

We show that, in the equilibrium phase of glass-forming hard-sphere fluids in three dimensions, the static length scales tentatively associated with the dynamical slowdown and the dynamical length characterizing spatial heterogeneities in the dynamics unambiguously decorrelate. The former grow at a much slower rate than the latter when density increases. This observation is valid for the dynamical range that is accessible to computer simulations, which roughly corresponds to that accessible in colloidal experiments. We also find that, in this same range, no one-to-one correspondence between relaxation time and point-to-set correlation length exists. These results point to the coexistence of several relaxation mechanisms in the dynamically accessible regime of three-dimensional hard-sphere glass formers.

Information processing characteristics in subtypes of multiple sclerosis.

PubMed

De Sonneville, L M J; Boringa, J B; Reuling, I E W; Lazeron, R H C; Adèr, H J; Polman, C H

2002-01-01

The purpose of this study was to evaluate information processing characteristics in patients with multiple sclerosis (MS). We selected 53 patients with MS and 58 matched healthy controls. Using computerized tests, we investigated focused, divided, sustained attention, and executive function, and attempted to pinpoint deficits in attentional control to peripheral or central processing stages. The results substantiate the hypothesis that the slowing of attention-demanding (controlled) information processing underlying more complex cognitive skills is general, i.e. irrespective of type of controlled processing, with MS patients being 40% slower than controls. MS patients may suffer from focused, and divided and sustained attention deficits, as well as from compromised central processing stages, with secondary progressive (SP) patients showing the most extensive range of deficits, closely followed by primary progressive (PP) patients, while relapsing-remitting (RR) patients appear to be much less affected. General slowing appears to be highest in PP and SP type MS patients (50% slower) versus relapsing-remitting MS (24% slower). In contrast to most previous results, (complex) processing speed appeared to be robustly correlated with severity of MS as measured by the expanded disability status scale and with disease duration. Patients did much less differ in accuracy of processing from controls, suggesting the importance of using time strategies in planning everyday life and job activities to compensate for or alleviate MS-related speed handicaps. Copyright 2002 Elsevier Science Ltd.

Transient slowing down relaxation dynamics of the supercooled dusty plasma liquid after quenching.

PubMed

Su, Yen-Shuo; Io, Chong-Wai; I, Lin

2012-07-01

The spatiotemporal evolutions of microstructure and motion in the transient relaxation toward the steady supercooled liquid state after quenching a dusty plasma Wigner liquid, formed by charged dust particles suspended in a low pressure discharge, are experimentally investigated through direct optical microscopy. It is found that the quenched liquid slowly evolves to a colder state with more heterogeneities in structure and motion. Hopping particles and defects appear in the form of clusters with multiscale cluster size distributions. Via the structure rearrangement induced by the reduced thermal agitation from the cold thermal bath after quenching, the temporarily stored strain energy can be cascaded through the network to different newly distorted regions and dissipated after transferring to nonlinearly coupled motions with different scales. It leads to the observed self-similar multiscale slowing down relaxation with power law increases of structural order and structural relaxation time, the similar power law decreases of particle motions at different time scales, and the stronger and slower fluctuations with increasing waiting time toward the new steady state.

Ultrafast charge separation dynamics in opaque, operational dye-sensitized solar cells revealed by femtosecond diffuse reflectance spectroscopy

PubMed Central

Ghadiri, Elham; Zakeeruddin, Shaik M.; Hagfeldt, Anders; Grätzel, Michael; Moser, Jacques-E.

2016-01-01

Efficient dye-sensitized solar cells are based on highly diffusive mesoscopic layers that render these devices opaque and unsuitable for ultrafast transient absorption spectroscopy measurements in transmission mode. We developed a novel sub-200 femtosecond time-resolved diffuse reflectance spectroscopy scheme combined with potentiostatic control to study various solar cells in fully operational condition. We studied performance optimized devices based on liquid redox electrolytes and opaque TiO2 films, as well as other morphologies, such as TiO2 fibers and nanotubes. Charge injection from the Z907 dye in all TiO2 morphologies was observed to take place in the sub-200 fs time scale. The kinetics of electron-hole back recombination has features in the picosecond to nanosecond time scale. This observation is significantly different from what was reported in the literature where the electron-hole back recombination for transparent films of small particles is generally accepted to occur on a longer time scale of microseconds. The kinetics of the ultrafast electron injection remained unchanged for voltages between +500 mV and –690 mV, where the injection yield eventually drops steeply. The primary charge separation in Y123 organic dye based devices was clearly slower occurring in two picoseconds and no kinetic component on the shorter femtosecond time scale was recorded. PMID:27095505

Effects of Eddy Viscosity on Time Correlations in Large Eddy Simulation

NASA Technical Reports Server (NTRS)

He, Guowei; Rubinstein, R.; Wang, Lian-Ping; Bushnell, Dennis M. (Technical Monitor)

2001-01-01

Subgrid-scale (SGS) models for large. eddy simulation (LES) have generally been evaluated by their ability to predict single-time statistics of turbulent flows such as kinetic energy and Reynolds stresses. Recent application- of large eddy simulation to the evaluation of sound sources in turbulent flows, a problem in which time, correlations determine the frequency distribution of acoustic radiation, suggest that subgrid models should also be evaluated by their ability to predict time correlations in turbulent flows. This paper compares the two-point, two-time Eulerian velocity correlation evaluated from direct numerical simulation (DNS) with that evaluated from LES, using a spectral eddy viscosity, for isotropic homogeneous turbulence. It is found that the LES fields are too coherent, in the sense that their time correlations decay more slowly than the corresponding time. correlations in the DNS fields. This observation is confirmed by theoretical estimates of time correlations using the Taylor expansion technique. Tile reason for the slower decay is that the eddy viscosity does not include the random backscatter, which decorrelates fluid motion at large scales. An effective eddy viscosity associated with time correlations is formulated, to which the eddy viscosity associated with energy transfer is a leading order approximation.

Surface regions of illusory images are detected with a slower processing speed than those of luminance-defined images.

PubMed

Mihaylova, Milena; Manahilov, Velitchko

2010-11-24

Research has shown that the processing time for discriminating illusory contours is longer than for real contours. We know, however, little whether the visual processes, associated with detecting regions of illusory surfaces, are also slower as those responsible for detecting luminance-defined images. Using a speed-accuracy trade-off (SAT) procedure, we measured accuracy as a function of processing time for detecting illusory Kanizsa-type and luminance-defined squares embedded in 2D static luminance noise. The data revealed that the illusory images were detected at slower processing speed than the real images, while the points in time, when accuracy departed from chance, were not significantly different for both stimuli. The classification images for detecting illusory and real squares showed that observers employed similar detection strategies using surface regions of the real and illusory squares. The lack of significant differences between the x-intercepts of the SAT functions for illusory and luminance-modulated stimuli suggests that the detection of surface regions of both images could be based on activation of a single mechanism (the dorsal magnocellular visual pathway). The slower speed for detecting illusory images as compared to luminance-defined images could be attributed to slower processes of filling-in of regions of illusory images within the dorsal pathway.

Real-Time Language Processing in School-Age Children with Specific Language Impairment

ERIC Educational Resources Information Center

Montgomery, James W.

2006-01-01

Background:School-age children with specific language impairment (SLI) exhibit slower real-time (i.e. immediate) language processing relative to same-age peers and younger, language-matched peers. Results of the few studies that have been done seem to indicate that the slower language processing of children with SLI is due to inefficient…

Controllability of multiplex, multi-time-scale networks

NASA Astrophysics Data System (ADS)

Pósfai, Márton; Gao, Jianxi; Cornelius, Sean P.; Barabási, Albert-László; D'Souza, Raissa M.

2016-09-01

The paradigm of layered networks is used to describe many real-world systems, from biological networks to social organizations and transportation systems. While recently there has been much progress in understanding the general properties of multilayer networks, our understanding of how to control such systems remains limited. One fundamental aspect that makes this endeavor challenging is that each layer can operate at a different time scale; thus, we cannot directly apply standard ideas from structural control theory of individual networks. Here we address the problem of controlling multilayer and multi-time-scale networks focusing on two-layer multiplex networks with one-to-one interlayer coupling. We investigate the practically relevant case when the control signal is applied to the nodes of one layer. We develop a theory based on disjoint path covers to determine the minimum number of inputs (Ni) necessary for full control. We show that if both layers operate on the same time scale, then the network structure of both layers equally affect controllability. In the presence of time-scale separation, controllability is enhanced if the controller interacts with the faster layer: Ni decreases as the time-scale difference increases up to a critical time-scale difference, above which Ni remains constant and is completely determined by the faster layer. We show that the critical time-scale difference is large if layer I is easy and layer II is hard to control in isolation. In contrast, control becomes increasingly difficult if the controller interacts with the layer operating on the slower time scale and increasing time-scale separation leads to increased Ni, again up to a critical value, above which Ni still depends on the structure of both layers. This critical value is largely determined by the longest path in the faster layer that does not involve cycles. By identifying the underlying mechanisms that connect time-scale difference and controllability for a simplified model, we provide crucial insight into disentangling how our ability to control real interacting complex systems is affected by a variety of sources of complexity.

Blind Seer: A Scalable Private DBMS

DTIC Science & Technology

2014-05-01

searchable index terms per DB row, in time comparable to (insecure) MySQL (many practical queries can be privately executed with work 1.2-3 times slower...than MySQL , although some queries are costlier). We support a rich query set, including searching on arbitrary boolean formulas on keywords and ranges...index terms per DB row, in time comparable to (insecure) MySQL (many practical queries can be privately executed with work 1.2-3 times slower than MySQL

Acoustic Reflex and House-Brackmann Rating Scale as Prognostic Indicators of Peripheral Facial Palsy in Neuroborreliosis.

PubMed

Sekelj, Alen; Đanić, Davorin

2017-09-01

Lyme borreliosis is a vector-borne infectious disease characterized by three disease stages. In the areas endemic for borreliosis, every acute facial palsy indicates serologic testing and implies specific approach to the disease. Th e aim of the study was to identify and confirm the value of acoustic refl ex and House-Brackman (HB) grading scale as prognostic indicators of facial palsy in neuroborreliosis. Th e study included 176 patients with acute facial palsy divided into three groups based on serologic testing: borreliosis, Bell's palsy, and facial palsy caused by herpes simplex virus type 1 (HSV-1). Study patients underwent baseline audiometry with tympanometry and acoustic reflex, whereas current state of facial palsy was assessed by the HB scale. Subsequently, the same tests were obtained on three occasions, i.e. in week 3, 6 and 12 of presentation. Th e patients diagnosed with borreliosis, Bell's palsy and HSV-1 differed according to the time to acoustic refl ex recovery, which took longest time in patients with borreliosis. Th ese patients had the highest percentage of suprastapedial lesions at all time points and recovery was achieved later as compared with the other two diagnoses. Th e mean score on the HB scale declined with time, also at a slower rate in borreliosis patients. Th e prognosis of acoustic refl ex and facial palsy recovery according to HB scale was not associated with the length of elapsed time. The results obtained in the present study strongly confirmed the role of acoustic reflex and HB grading scale as prognostic indicators of facial palsy in neuroborreliosis.

Limitations of heterogeneous models of liquid dynamics: very slow rate exchange in the excess wing.

PubMed

Samanta, Subarna; Richert, Ranko

2014-02-07

For several molecular glass formers, the nonlinear dielectric effects (NDE's) are investigated for the so-called excess wing regime, i.e., for the relatively high frequencies between 10(2) and 10(7) times the peak loss frequency. It is found that significant nonlinear behavior persists across the entire frequency window of this study, and that its magnitude traces the temperature dependence of the activation energy. A time resolved measurement of the dielectric loss at fields up to 480 kV/cm across tens of thousands of periods reveals that it takes an unexpectedly long time for the steady state NDE to develop. For various materials and at different temperatures and frequencies, it is found that the average structural relaxation with time scale τα governs the equilibration of these fast modes that are associated with time constants τ which are up to 10(7) times shorter than τα. It is argued that true indicators of structural relaxation (such as rate exchange and aging) of these fast modes are slaved to macroscopic softening on the time scale of τα, and thus many orders of magnitude slower than the time constant of the mode itself.

Modeling of GIC Impacts in Different Time Scales, and Validation with Measurement Data

NASA Astrophysics Data System (ADS)

Shetye, K.; Birchfield, A.; Overbye, T. J.; Gannon, J. L.

2016-12-01

Geomagnetically induced currents (GICs) have mostly been associated with geomagnetic disturbances (GMDs) originating from natural events such as solar coronal mass ejections. There is another, man-made, phenomenon that can induce GICs in the bulk power grid. Detonation of nuclear devices at high altitudes can give rise to electromagnetic pulses (EMPs) that induce electric fields at the earth's surface. EMPs cause three types of waves on different time scales, the slowest of which, E3, can induce GICs similar to the way GMDs do. The key difference between GMDs and EMPs is the rise time of the associated electric field. E3 electric fields are in the msec. to sec. range, whereas GMD electric fields are slower (sec. to min.). Similarly, the power grid and its components also operate and respond to disturbances in various time frames, right from electromagnetic transients (eg. lightning propagation) in the micro second range to steady state power flow ( hours). Hence, different power system component models need to be used to analyze the impacts of GICs caused by GMDs, and EMPs. For instance, for the slower GMD based GICs, a steady-state (static) analysis of the system is sufficient. That is, one does not need to model the dynamic components of a power system, such as the rotating machine of a generator, or generator controls such as exciters, etc. The latter become important in the case of an E3 EMP wave, which falls in the power system transient stability time frame of msec. to sec. This talk will first give an overview of the different time scales and models associated with power system operations, and where GMD and EMPs fit in. This is helpful to develop appropriate system models and test systems for analyzing impacts of GICs from various sources, and developing mitigation measures. Example test systems developed for GMD and EMP analysis, and their key modeling and analysis differences will be presented. After the modeling is discussed, results of validating simulated GICs with GIC measurements from a utility for a recent moderate GMD event will be shown, using NSF Earthscope derived electric fields. The end goal is to validate 1) power system models used for GICs, and 2) ground models to see whether 3D ground models provide better results than the hitherto-used 1D ground models.

Identification of effective exciton-exciton annihilation in squaraine-squaraine copolymers.

PubMed

Hader, Kilian; May, Volkhard; Lambert, Christoph; Engel, Volker

2016-05-11

Ultrafast time-resolved transient absorption spectroscopy is able to monitor the fate of the excited state population in molecular aggregates or polymers. Due to many competing decay processes, the identification of exciton-exciton annihilation (EEA) is difficult. Here, we use a microscopic model to describe exciton annihilation processes in squaraine-squaraine copolymers. Transient absorption time traces measured at different laser powers exhibit an unusual time-dependence. The analysis points towards dynamics taking place on three time-scales. Immediately after laser-excitation a localization of excitons takes place within the femtosecond time-regime. This is followed by exciton-exciton annihilation which is responsible for a fast decay of the exciton population. At later times, excitations being localized on units which are not directly connected remain so that diffusion dominates the dynamics and leads to a slower decay. We thus provide evidence for EEA tracked by time-resolved spectroscopy which has not been reported that clearly before.

Origin of two time-scale regimes in potentiometric titration of metal oxides. A replica kinetic Monte Carlo study.

PubMed

Zarzycki, Piotr; Rosso, Kevin M

2009-06-16

Replica kinetic Monte Carlo simulations were used to study the characteristic time scales of potentiometric titration of the metal oxides and (oxy)hydroxides. The effect of surface heterogeneity and surface transformation on the titration kinetics were also examined. Two characteristic relaxation times are often observed experimentally, with the trailing slower part attributed to surface nonuniformity, porosity, polymerization, amorphization, and other dynamic surface processes induced by unbalanced surface charge. However, our simulations show that these two characteristic relaxation times are intrinsic to the proton-binding reaction for energetically homogeneous surfaces, and therefore surface heterogeneity or transformation does not necessarily need to be invoked. However, all such second-order surface processes are found to intensify the separation and distinction of the two kinetic regimes. The effect of surface energetic-topographic nonuniformity, as well dynamic surface transformation, interface roughening/smoothing were described in a statistical fashion. Furthermore, our simulations show that a shift in the point-of-zero charge is expected from increased titration speed, and the pH-dependence of the titration measurement error is in excellent agreement with experimental studies.

The formation of CdS quantum dots and Au nanoparticles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schiener, Andreas; Schmidt, Ella; Bergmann, Christoph

Abstract We report on microsecond-resolved in-situ SAXS experiments of the early nucleation and growth behavior of both cadmium sulfide (CdS) quantum dots in aqueous solution including the temperature dependence and of gold (Au) nanoparticles. A novel free-jet setup was developped to access reaction times as early as 20 μs. As the signal in particular in the beginning of the reaction is weak the containment-free nature of this sample environment prooved crucial. The SAXS data reveal a two-step pathway with a surprising stability of a structurally relaxed cluster with a diameter of about 2 nm. While these develop rapidly by ionicmore » assembly, a further slower growth is attributed to cluster attachment. WAXS diffraction confirms, that the particles at this early stage are not yet crystalline. This growth mode is confirmed for a temperature range from 25°C to 45°C. An energy barrier for the diffusion of primary clusters in water of 0.60 eV was experimentally observed in agreement with molecular simulations. To access reaction times beyond 100 ms, a stopped-drop setup -again contaiment- free is introduced. SAXS experiments on the growth of Au nanoparticles on an extended time scale provide a much slower growth with one population only. Further, the influence of ionizing X-ray radiation on the Au particle fromation and growth is discussed.« less

Adsorption and Exchange Dynamics in Aging Hydroxyethylcellulose Layers on Silica.

PubMed

Mubarekyan; Santore

2000-07-15

The adsorption kinetics of hydroxyethylcellulose (HEC) on silica and relaxations in adsorbed HEC layers were probed using total internal reflectance fluorescence and near-Brewster reflectivity. Like many random-coil polymers, HEC was found to adsorb at the transport-limited rate. Relaxations occurred at nearly constant interfacial mass when HEC layers were exposed to aqueous solvent, causing the subsequent exchange of chains between the layer and the free solution to become increasingly hindered. Eventually, on the time scale of a day, layers became immobilized and unable to accommodate chains from free solution. A continued fluorescence decay, beyond time scales that could be probed with self exchange, suggested further relaxations of the adsorbed HEC. The polydisperse HEC system (with an average molecular weight near 450,000) behaved qualitatively similar to molecular weight standard polyethylene oxide (PEO) layers on silica. For instance, relaxations in PEO layers occurred on a time scale of 10-20 h, like the HEC layers. Young layers of the latter, however, exhibited self-exchange kinetics that were an order of magnitude slower than PEO layers of similar age. This difference in adsorbed layer dynamics was attributed to HEC's stiffer backbone, compared with flexible PEO. Copyright 2000 Academic Press.

Flexibility increases lift on passive fluttering wings

NASA Astrophysics Data System (ADS)

Tam, Daniel; Bush, John

2013-11-01

We examine the influence of flexibility on the side-to-side fluttering motion of passive wings settling under the influence of gravity. This effect is examined through an experimental investigation of deformable rectangular wings falling in a water tank. Our results demonstrate the existence of an optimal flexibility, for which flexible wings remain flying twice longer and hence settle twice slower compared to rigid wings of identical mass and geometry. Flow visualizations and measurements provide key insight to elucidate the role of flexibility in generating increased lift and wing circulation by shedding additional vorticity at the turning point. Theoretical scalings are derived from a reduced model of the flight dynamics in qualitative and quantitative agreement with experiments. These scalings rationalize the strong positive correlation between flexibility and time of flight.

Fast and Accurate Simulation of the Cray XMT Multithreaded Supercomputer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Villa, Oreste; Tumeo, Antonino; Secchi, Simone

Irregular applications, such as data mining and analysis or graph-based computations, show unpredictable memory/network access patterns and control structures. Highly multithreaded architectures with large processor counts, like the Cray MTA-1, MTA-2 and XMT, appear to address their requirements better than commodity clusters. However, the research on highly multithreaded systems is currently limited by the lack of adequate architectural simulation infrastructures due to issues such as size of the machines, memory footprint, simulation speed, accuracy and customization. At the same time, Shared-memory MultiProcessors (SMPs) with multi-core processors have become an attractive platform to simulate large scale machines. In this paper, wemore » introduce a cycle-level simulator of the highly multithreaded Cray XMT supercomputer. The simulator runs unmodified XMT applications. We discuss how we tackled the challenges posed by its development, detailing the techniques introduced to make the simulation as fast as possible while maintaining a high accuracy. By mapping XMT processors (ThreadStorm with 128 hardware threads) to host computing cores, the simulation speed remains constant as the number of simulated processors increases, up to the number of available host cores. The simulator supports zero-overhead switching among different accuracy levels at run-time and includes a network model that takes into account contention. On a modern 48-core SMP host, our infrastructure simulates a large set of irregular applications 500 to 2000 times slower than real time when compared to a 128-processor XMT, while remaining within 10\\% of accuracy. Emulation is only from 25 to 200 times slower than real time.« less

Temporal variations of radon concentration in the saturated soil of Alpine grassland: the role of groundwater flow.

PubMed

Perrier, Frédéric; Richon, Patrick; Sabroux, Jean-Christophe

2009-03-15

Radon concentration has been monitored from 1995 to 1999 in the soil of the Sur-Frêtes ridge (French Alps), covered with snow from November to April. Measurements were performed at 70 cm depth, with a sampling time of 1 h, at two points: the summit of the ridge, at an altitude of 1792 m, and the bottom of the ridge, at an altitude of 1590 m. On the summit, radon concentration shows a moderate seasonal variation, with a high value from October to April (winter), and a low value from May to September (summer). At the bottom of the ridge, a large and opposite seasonal variation is observed, with a low value in winter and a high value in summer. Fluctuations of the radon concentration seem to be associated with temperature variations, an effect which is largely delusory. Indeed, these variations are actually due to water infiltration. A simplified mixing model is used to show that, at the summit of the ridge, two effects compete in the radon response: a slow infiltration response, rich in radon, with a typical time scale of days, and a fast infiltration of radon-poor rainwater. At the bottom of the ridge, similarly, two groundwater contributions compete: one slow infiltration response, similar to the response seen at the summit, and an additional slower response, with a typical time scale of about a month. This second slower response can be interpreted as the aquifer discharge in response to snow melt. This study shows that, while caution is necessary to properly interpret the various effects, the temporal variations of the radon concentration in soil can be understood reasonably well, and appear to be a sensitive tool to study the subtle interplay of near surface transfer processes of groundwater with different transit times.

Cooperative ordering and kinetics of cellulose nanocrystal alignment in a magnetic field

DOE PAGES

De France, Kevin J.; Yager, Kevin G.; Hoare, Todd; ...

2016-07-13

Cellulose nanocrystals (CNCs) are emerging nanomaterials that form chiral nematic liquid crystals above a critical concentration (C*) and additionally orient within electromagnetic fields. The control over CNC alignment is significant for materials processing and end use; to date, magnetic alignment has been demonstrated using only strong fields over extended or arbitrary time scales. This work investigates the effects of comparatively weak magnetic fields (0–1.2 T) and CNC concentration (1.65–8.25 wt %) on the kinetics and degree of CNC ordering using small-angle X-ray scattering. Interparticle spacing, correlation length, and orientation order parameters (η and S) increased with time and field strengthmore » following a sigmoidal profile. In a 1.2 T magnetic field for CNC suspensions above C*, partial alignment occurred in under 2 min followed by slower cooperative ordering to achieve nearly perfect alignment in under 200 min (S = –0.499 where S = –0.5 indicates perfect antialignment). At 0.56 T, nearly perfect alignment was also achieved, yet the ordering was 36% slower. Outside of a magnetic field, the order parameter plateaued at 52% alignment (S = –0.26) after 5 h, showcasing the drastic effects of relatively weak magnetic fields on CNC alignment. For suspensions below C*, no magnetic alignment was detected.« less

Postseismic viscoelastic surface deformation and stress. Part 1: Theoretical considerations, displacement and strain calculations

NASA Technical Reports Server (NTRS)

Cohen, S. C.

1979-01-01

A model of viscoelastic deformations associated with earthquakes is presented. A strike-slip fault is represented by a rectangular dislocation in a viscoelastic layer (lithosphere) lying over a viscoelastic half-space (asthenosphere). Deformations occur on three time scales. The initial response is governed by the instantaneous elastic properties of the earth. A slower response is associated with viscoelastic relaxation of the lithosphere and a yet slower response is due to viscoelastic relaxation of the asthenosphere. The major conceptual contribution is the inclusion of lithospheric viscoelastic properties into a dislocation model of earthquake related deformations and stresses. Numerical calculations using typical fault parameters reveal that the postseismic displacements and strains are small compared to the coseismic ones near the fault, but become significant further away. Moreover, the directional sense of the deformations attributable to the elastic response, the lithospheric viscoelastic softening, and the asthenospheric viscoelastic flow may differ and depend on location and model details. The results and theoretical arguments suggest that the stress changes accompanying lithospheric relaxation may also be in a different sense than and be larger than the strain changes.

Restricted lithium ion dynamics in PEO-based block copolymer electrolytes measured by high-field nuclear magnetic resonance relaxation

NASA Astrophysics Data System (ADS)

Huynh, Tan Vu; Messinger, Robert J.; Sarou-Kanian, Vincent; Fayon, Franck; Bouchet, Renaud; Deschamps, Michaël

2017-10-01

The intrinsic ionic conductivity of polyethylene oxide (PEO)-based block copolymer electrolytes is often assumed to be identical to the conductivity of the PEO homopolymer. Here, we use high-field 7Li nuclear magnetic resonance (NMR) relaxation and pulsed-field-gradient (PFG) NMR diffusion measurements to probe lithium ion dynamics over nanosecond and millisecond time scales in PEO and polystyrene (PS)-b-PEO-b-PS electrolytes containing the lithium salt LiTFSI. Variable-temperature longitudinal (T1) and transverse (T2) 7Li NMR relaxation rates were acquired at three magnetic field strengths and quantitatively analyzed for the first time at such fields, enabling us to distinguish two characteristic time scales that describe fluctuations of the 7Li nuclear electric quadrupolar interaction. Fast lithium motions [up to O (ns)] are essentially identical between the two polymer electrolytes, including sub-nanosecond vibrations and local fluctuations of the coordination polyhedra between lithium and nearby oxygen atoms. However, lithium dynamics over longer time scales [O (10 ns) and greater] are slower in the block copolymer compared to the homopolymer, as manifested experimentally by their different transverse 7Li NMR relaxation rates. Restricted dynamics and altered thermodynamic behavior of PEO chains anchored near PS domains likely explain these results.

Time-oriented hierarchical method for computation of principal components using subspace learning algorithm.

PubMed

Jankovic, Marko; Ogawa, Hidemitsu

2004-10-01

Principal Component Analysis (PCA) and Principal Subspace Analysis (PSA) are classic techniques in statistical data analysis, feature extraction and data compression. Given a set of multivariate measurements, PCA and PSA provide a smaller set of "basis vectors" with less redundancy, and a subspace spanned by them, respectively. Artificial neurons and neural networks have been shown to perform PSA and PCA when gradient ascent (descent) learning rules are used, which is related to the constrained maximization (minimization) of statistical objective functions. Due to their low complexity, such algorithms and their implementation in neural networks are potentially useful in cases of tracking slow changes of correlations in the input data or in updating eigenvectors with new samples. In this paper we propose PCA learning algorithm that is fully homogeneous with respect to neurons. The algorithm is obtained by modification of one of the most famous PSA learning algorithms--Subspace Learning Algorithm (SLA). Modification of the algorithm is based on Time-Oriented Hierarchical Method (TOHM). The method uses two distinct time scales. On a faster time scale PSA algorithm is responsible for the "behavior" of all output neurons. On a slower scale, output neurons will compete for fulfillment of their "own interests". On this scale, basis vectors in the principal subspace are rotated toward the principal eigenvectors. At the end of the paper it will be briefly analyzed how (or why) time-oriented hierarchical method can be used for transformation of any of the existing neural network PSA method, into PCA method.

Frequency adaptive metadynamics for the calculation of rare-event kinetics

NASA Astrophysics Data System (ADS)

Wang, Yong; Valsson, Omar; Tiwary, Pratyush; Parrinello, Michele; Lindorff-Larsen, Kresten

2018-08-01

The ability to predict accurate thermodynamic and kinetic properties in biomolecular systems is of both scientific and practical utility. While both remain very difficult, predictions of kinetics are particularly difficult because rates, in contrast to free energies, depend on the route taken. For this reason, specific enhanced sampling methods are needed to calculate long-time scale kinetics. It has recently been demonstrated that it is possible to recover kinetics through the so-called "infrequent metadynamics" simulations, where the simulations are biased in a way that minimally corrupts the dynamics of moving between metastable states. This method, however, requires the bias to be added slowly, thus hampering applications to processes with only modest separations of time scales. Here we present a frequency-adaptive strategy which bridges normal and infrequent metadynamics. We show that this strategy can improve the precision and accuracy of rate calculations at fixed computational cost and should be able to extend rate calculations for much slower kinetic processes.

A large-scale circuit mechanism for hierarchical dynamical processing in the primate cortex

PubMed Central

Chaudhuri, Rishidev; Knoblauch, Kenneth; Gariel, Marie-Alice; Kennedy, Henry; Wang, Xiao-Jing

2015-01-01

We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, transient responses to input (appropriate for sensory processing), whereas association areas integrate inputs over time and exhibit persistent activity (suitable for decision-making and working memory). The model displays multiple temporal hierarchies, as evidenced by contrasting responses to visual versus somatosensory stimulation. Moreover, slower prefrontal and temporal areas have a disproportionate impact on global brain dynamics. These findings establish a circuit mechanism for “temporal receptive windows” that are progressively enlarged along the cortical hierarchy, suggest an extension of time integration in decision-making from local to large circuits, and should prompt a re-evaluation of the analysis of functional connectivity (measured by fMRI or EEG/MEG) by taking into account inter-areal heterogeneity. PMID:26439530

Ultrafast photoinduced electron transfer in the micelle and the gel phase of a PEO-PPO-PEO triblock copolymer

NASA Astrophysics Data System (ADS)

Mandal, Ujjwal; Ghosh, Subhadip; Dey, Shantanu; Adhikari, Aniruddha; Bhattacharyya, Kankan

2008-04-01

Ultrafast photoinduced electron transfer (PET) from N,N-dimethylaniline (DMA) to coumarin dyes is studied in the micelle and the gel phase of a triblock copolymer, (PEO)20-(PPO)70-(PEO)20 (Pluronic P123) by picosecond and femtosecond emission spectroscopies. The rate of PET in a P123 micelle and gel is found to be nonexponential and faster than the slow components of solvation dynamics. In a P123 micelle and gel, PET occurs on multiple time scales ranging from a subpicosecond time scale to a few nanoseconds. In the gel phase, the highest rate constant (9.3×109M-1s-1) of ET for C152 is about two times higher than that (3.8×109M-1s-1) observed in micelle phase. The ultrafast components of electron transfer (ET) exhibits a bell shaped dependence with the free energy change which is similar to the Marcus inversion. Possible reasons for slower PET in P123 micelle compared to other micelles and relative to P123 gel are discussed.

The spectrum of random magnetic fields in the mean field dynamo theory of the Galactic magnetic field

NASA Technical Reports Server (NTRS)

Kulsrud, Russell M.; Anderson, Stephen W.

1992-01-01

The fluctuation spectrum that must arise in a mean field dynamo generation of galactic fields if the initial field is weak is considered. A kinetic equation for its evolution is derived and solved. The spectrum evolves by transfer of energy from one magnetic mode to another by interaction with turbulent velocity modes. This kinetic equation is valid in the limit that the rate of evolution of the magnetic modes is slower than the reciprocal decorrelation time of the turbulent modes. This turns out to be the case by a factor greater than 3. Most of the fluctuation energy concentrates on small scales, shorter than the hydrodynamic turbulent scales. The fluctuation energy builds up to equipartition with the turbulent energy in times that are short compared to the e-folding time of the mean field. The turbulence becomes strongly modified before the dynamo amplification starts. Thus, the kinematic assumption of the mean dynamo theory is invalid. Thus, the galactic field must have a primordial origin, although it may subsequently be modified by dynamo action.

Time Scale Hierarchies in the Functional Organization of Complex Behaviors

PubMed Central

Perdikis, Dionysios; Huys, Raoul; Jirsa, Viktor K.

2011-01-01

Traditional approaches to cognitive modelling generally portray cognitive events in terms of ‘discrete’ states (point attractor dynamics) rather than in terms of processes, thereby neglecting the time structure of cognition. In contrast, more recent approaches explicitly address this temporal dimension, but typically provide no entry points into cognitive categorization of events and experiences. With the aim to incorporate both these aspects, we propose a framework for functional architectures. Our approach is grounded in the notion that arbitrary complex (human) behaviour is decomposable into functional modes (elementary units), which we conceptualize as low-dimensional dynamical objects (structured flows on manifolds). The ensemble of modes at an agent’s disposal constitutes his/her functional repertoire. The modes may be subjected to additional dynamics (termed operational signals), in particular, instantaneous inputs, and a mechanism that sequentially selects a mode so that it temporarily dominates the functional dynamics. The inputs and selection mechanisms act on faster and slower time scales then that inherent to the modes, respectively. The dynamics across the three time scales are coupled via feedback, rendering the entire architecture autonomous. We illustrate the functional architecture in the context of serial behaviour, namely cursive handwriting. Subsequently, we investigate the possibility of recovering the contributions of functional modes and operational signals from the output, which appears to be possible only when examining the output phase flow (i.e., not from trajectories in phase space or time). PMID:21980278

Approach and separation of quantum vortices with balanced cores

NASA Astrophysics Data System (ADS)

Kerr, Robert M.; Rorai, C.; Skipper, J.; Sreenivasan, K. R.

2014-11-01

Using two innovations, smooth but different, scaling laws for the reconnection of pairs of initially orthogonal and anti-parallel quantum vortices are obtained using the three-dimensional Gross-Pitaevskii equations. For the anti-parallel case, the scaling laws just before and after reconnection obey the dimensional δ ~ | t - tr| 1 / 2 prediction with temporal symmetry about the reconnection time tr and physical space symmetry about xr, the mid-point between the vortices, with extensions forming the edges of an equilateral pyramid. For all of the orthogonal cases, before reconnection δin ~(t -tr) 1 / 3 and after reconnection δout ~(tr - t) 2 / 3 , which are respectively slower and faster than the dimensional prediction. In these cases, the reconnection takes place in a plane defined by the directions of the curvature and vorticity. Robert.Kerr@warwick.ac.uk.

A hierarchy of time-scales and the brain.

PubMed

Kiebel, Stefan J; Daunizeau, Jean; Friston, Karl J

2008-11-01

In this paper, we suggest that cortical anatomy recapitulates the temporal hierarchy that is inherent in the dynamics of environmental states. Many aspects of brain function can be understood in terms of a hierarchy of temporal scales at which representations of the environment evolve. The lowest level of this hierarchy corresponds to fast fluctuations associated with sensory processing, whereas the highest levels encode slow contextual changes in the environment, under which faster representations unfold. First, we describe a mathematical model that exploits the temporal structure of fast sensory input to track the slower trajectories of their underlying causes. This model of sensory encoding or perceptual inference establishes a proof of concept that slowly changing neuronal states can encode the paths or trajectories of faster sensory states. We then review empirical evidence that suggests that a temporal hierarchy is recapitulated in the macroscopic organization of the cortex. This anatomic-temporal hierarchy provides a comprehensive framework for understanding cortical function: the specific time-scale that engages a cortical area can be inferred by its location along a rostro-caudal gradient, which reflects the anatomical distance from primary sensory areas. This is most evident in the prefrontal cortex, where complex functions can be explained as operations on representations of the environment that change slowly. The framework provides predictions about, and principled constraints on, cortical structure-function relationships, which can be tested by manipulating the time-scales of sensory input.

The Impact of Frictional Healing on Stick-Slip Recurrence Interval and Stress Drop: Implications for Earthquake Scaling

NASA Astrophysics Data System (ADS)

Im, Kyungjae; Elsworth, Derek; Marone, Chris; Leeman, John

2017-12-01

Interseismic frictional healing is an essential process in the seismic cycle. Observations of both natural and laboratory earthquakes demonstrate that the magnitude of stress drop scales with the logarithm of recurrence time, which is a cornerstone of the rate and state friction (RSF) laws. However, the origin of this log linear behavior and short time "cutoff" for small recurrence intervals remains poorly understood. Here we use RSF laws to demonstrate that the back-projected time of null-healing intrinsically scales with the initial frictional state θi. We explore this behavior and its implications for (1) the short-term cutoff time of frictional healing and (2) the connection between healing rates derived from stick-slip sliding versus slide-hold-slide tests. We use a novel, continuous solution of RSF for a one-dimensional spring-slider system with inertia. The numerical solution continuously traces frictional state evolution (and healing) and shows that stick-slip cutoff time also scales with frictional state at the conclusion of the dynamic slip process θi (=Dc/Vpeak). This numerical investigation on the origins of stick-slip response is verified by comparing laboratory data for a range of peak slip velocities. Slower slip motions yield lesser magnitude of friction drop at a given time due to higher frictional state at the end of each slip event. Our results provide insight on the origin of log linear stick-slip evolution and suggest an approach to estimating the critical slip distance on faults that exhibit gradual accelerations, such as for slow earthquakes.

Time-resolved study of SrTiO3 homoepitaxial pulsed-laser deposition using surface x-ray diffraction

NASA Astrophysics Data System (ADS)

Eres, G.; Tischler, J. Z.; Yoon, M.; Larson, B. C.; Rouleau, C. M.; Lowndes, D. H.; Zschack, P.

2002-05-01

Homoepitaxy of SrTiO3 by pulsed-laser deposition has been studied using in situ time-resolved surface x-ray diffraction in the temperature range of 310 °C to 780 °C. Using a two-detector configuration, surface x-ray diffraction intensities were monitored simultaneously at the (0 0 1/2) specular and the (0 1 1/2) off-specular truncation rod positions. Abrupt intensity changes in both the specular and off-specular rods after laser pulses indicated prompt crystallization into SrTiO3 layers followed by slower intra- and interlayer surface rearrangements on time scales of seconds. Specular rod intensity oscillations indicated layer-by-layer growth, while off-specular rod intensity measurements suggested the presence of transient in-plane lattice distortions for depositions above 600 °C.

Watching Individual Enzymes at Work

NASA Astrophysics Data System (ADS)

Blank, Kerstin; Rocha, Susana; De Cremer, Gert; Roeffaers, Maarten B. J.; Uji-i, Hiroshi; Hofkens, Johan

Single-molecule fluorescence experiments are a powerful tool to analyze reaction mechanisms of enzymes. Because of their unique potential to detect heterogeneities in space and time, they have provided unprecedented insights into the nature and mechanisms of conformational changes related to the catalytic reaction. The most important finding from experiments with single enzymes is the generally observed phenomenon that the catalytic rate constants fluctuate over time (dynamic disorder). These fluctuations originate from conformational changes occurring on time scales, which are similar to or slower than that of the catalytic reaction. Here, we summarize experiments with enzymes that show dynamic disorder and introduce new experimental strategies showing how single-molecule fluorescence experiments can be applied to address other open questions in medical and industrial enzymology, such as enzyme inactivation processes, reactant transfer in cascade reactions, and the mechanisms of interfacial catalysis.

Multi-GPU accelerated three-dimensional FDTD method for electromagnetic simulation.

PubMed

Nagaoka, Tomoaki; Watanabe, Soichi

2011-01-01

Numerical simulation with a numerical human model using the finite-difference time domain (FDTD) method has recently been performed in a number of fields in biomedical engineering. To improve the method's calculation speed and realize large-scale computing with the numerical human model, we adapt three-dimensional FDTD code to a multi-GPU environment using Compute Unified Device Architecture (CUDA). In this study, we used NVIDIA Tesla C2070 as GPGPU boards. The performance of multi-GPU is evaluated in comparison with that of a single GPU and vector supercomputer. The calculation speed with four GPUs was approximately 3.5 times faster than with a single GPU, and was slightly (approx. 1.3 times) slower than with the supercomputer. Calculation speed of the three-dimensional FDTD method using GPUs can significantly improve with an expanding number of GPUs.

Transition States and transition state analogue interactions with enzymes.

PubMed

Schramm, Vern L

2015-04-21

Enzymatic transition states have lifetimes of a few femtoseconds (fs). Computational analysis of enzyme motions leading to transition state formation suggests that local catalytic site motions on the fs time scale provide the mechanism to locate transition states. An experimental test of protein fs motion and its relation to transition state formation can be provided by isotopically heavy proteins. Heavy enzymes have predictable mass-altered bond vibration states without altered electrostatic properties, according to the Born-Oppenheimer approximation. On-enzyme chemistry is slowed in most heavy proteins, consistent with altered protein bond frequencies slowing the search for the transition state. In other heavy enzymes, structural changes involved in reactant binding and release are also influenced. Slow protein motions associated with substrate binding and catalytic site preorganization are essential to allow the subsequent fs motions to locate the transition state and to facilitate the efficient release of products. In the catalytically competent geometry, local groups move in stochastic atomic motion on the fs time scale, within transition state-accessible conformations created by slower protein motions. The fs time scale for the transition state motions does not permit thermodynamic equilibrium between the transition state and stable enzyme states. Isotopically heavy enzymes provide a diagnostic tool for fast coupled protein motions to transition state formation and mass-dependent conformational changes. The binding of transition state analogue inhibitors is the opposite in catalytic time scale to formation of the transition state but is related by similar geometries of the enzyme-transition state and enzyme-inhibitor interactions. While enzymatic transition states have lifetimes as short as 10(-15) s, transition state analogues can bind tightly to enzymes with release rates greater than 10(3) s. Tight-binding transition state analogues stabilize the rare but evolved enzymatic geometry to form the transition state. Evolution to efficient catalysis optimized this geometry and its stabilization by a transition state mimic results in tight binding. Release rates of transition state analogues are orders of magnitude slower than product release in normal catalytic function. During catalysis, product release is facilitated by altered chemistry. Compared to the weak associations found in Michaelis complexes, transition state analogues involve strong interactions related to those in the transition state. Optimum binding of transition state analogues occurs when the complex retains the system motions intrinsic to transition state formation. Conserved dynamic motion retains the entropic components of inhibitor complexes, improving the thermodynamics of analogue binding.

Computer simulations of structural transitions in large ferrofluid aggregates

NASA Astrophysics Data System (ADS)

Yoon, Mina; Tomanek, David

2003-03-01

We have developed a quaternion molecular dynamics formalism to study structural transitions in systems of ferrofluid particles in colloidal suspensions. Our approach takes advantage of the viscous damping provided by the surrounding liquid and enables us to study the time evolution of these systems over milli-second time periods as a function of the number of particles, initial geometry, and an externally applied magnetic field. Our computer simulations for aggregates containing tens to hundreds of ferrofluid particles suggest that these systems relax to the global optimum structure in a step-wise manner. During the relaxation process, the potential energy decreases by two mechanisms, which occur on different time scales. Short time periods associated with structural relaxations within a given morphology are followed by much slower processes that generally lead to a simpler morphology. We discuss possible applications of these externally driven structural transitions for targeted medication delivery.

Near-realtime simulations of biolelectric activity in small mammalian hearts using graphical processing units

PubMed Central

Vigmond, Edward J.; Boyle, Patrick M.; Leon, L. Joshua; Plank, Gernot

2014-01-01

Simulations of cardiac bioelectric phenomena remain a significant challenge despite continual advancements in computational machinery. Spanning large temporal and spatial ranges demands millions of nodes to accurately depict geometry, and a comparable number of timesteps to capture dynamics. This study explores a new hardware computing paradigm, the graphics processing unit (GPU), to accelerate cardiac models, and analyzes results in the context of simulating a small mammalian heart in real time. The ODEs associated with membrane ionic flow were computed on traditional CPU and compared to GPU performance, for one to four parallel processing units. The scalability of solving the PDE responsible for tissue coupling was examined on a cluster using up to 128 cores. Results indicate that the GPU implementation was between 9 and 17 times faster than the CPU implementation and scaled similarly. Solving the PDE was still 160 times slower than real time. PMID:19964295

Ultrafast Photodissociation Dynamics of Nitromethane.

PubMed

Nelson, Tammie; Bjorgaard, Josiah; Greenfield, Margo; Bolme, Cindy; Brown, Katie; McGrane, Shawn; Scharff, R Jason; Tretiak, Sergei

2016-02-04

Nitromethane (NM), a high explosive (HE) with low sensitivity, is known to undergo photolysis upon ultraviolet (UV) irradiation. The optical transparency, homogeneity, and extensive study of NM make it an ideal system for studying photodissociation mechanisms in conventional HE materials. The photochemical processes involved in the decomposition of NM could be applied to the future design of controllable photoactive HE materials. In this study, the photodecomposition of NM from the nπ* state excited at 266 nm is being investigated on the femtosecond time scale. UV femtosecond transient absorption (TA) spectroscopy and excited state femtosecond stimulated Raman spectroscopy (FSRS) are combined with nonadiabatic excited state molecular dynamics (NA-ESMD) simulations to provide a unified picture of NM photodecomposition. The FSRS spectrum of the photoproduct exhibits peaks in the NO2 region and slightly shifted C-N vibrational peaks pointing to methyl nitrite formation as the dominant photoproduct. A total photolysis quantum yield of 0.27 and an nπ* state lifetime of ∼20 fs were predicted from NA-ESMD simulations. Predicted time scales revealed that NO2 dissociation occurs in 81 ± 4 fs and methyl nitrite formation is much slower having a time scale of 452 ± 9 fs corresponding to the excited state absorption feature with a decay of 480 ± 17 fs observed in the TA spectrum. Although simulations predict C-N bond cleavage as the primary photochemical process, the relative time scales are consistent with isomerization occurring via NO2 dissociation and subsequent rebinding of the methyl radical and nitrogen dioxide.

Slow Noncollinear Coulomb Scattering in the Vicinity of the Dirac Point in Graphene.

PubMed

König-Otto, J C; Mittendorff, M; Winzer, T; Kadi, F; Malic, E; Knorr, A; Berger, C; de Heer, W A; Pashkin, A; Schneider, H; Helm, M; Winnerl, S

2016-08-19

The Coulomb scattering dynamics in graphene in energetic proximity to the Dirac point is investigated by polarization resolved pump-probe spectroscopy and microscopic theory. Collinear Coulomb scattering rapidly thermalizes the carrier distribution in k directions pointing radially away from the Dirac point. Our study reveals, however, that, in almost intrinsic graphene, full thermalization in all directions relying on noncollinear scattering is much slower. For low photon energies, carrier-optical-phonon processes are strongly suppressed and Coulomb mediated noncollinear scattering is remarkably slow, namely on a ps time scale. This effect is very promising for infrared and THz devices based on hot carrier effects.

A decadal glimpse on climate and burn severity influences on ponderosa pine post-fire recovery

NASA Astrophysics Data System (ADS)

Newingham, B. A.; Hudak, A. T.; Bright, B. C.; Smith, A.; Khalyani, A. H.

2016-12-01

Climate change is predicted to affect plants at the margins of their distribution. Thus, ecosystem recovery after fire is likely to vary with climate and may be slowest in drier and hotter areas. However, fire regime characteristics, including burn severity, may also affect vegetation recovery. We assessed vegetation recovery one and 9-15 years post-fire in North American ponderosa pine ecosystems distributed across climate and burn severity gradients. Using climate predictors derived from downscaled 1993-2011 climate normals, we predicted vegetation recovery as indicated by Normalized Burn Ratio derived from 1984-2012 Landsat time series imagery. Additionally, we collected field vegetation measurements to examine local topographic controls on burn severity and post-fire vegetation recovery. At a regional scale, we hypothesized a positive relationship between precipitation and recovery time and a negative relationship between temperature and recovery time. At the local scale, we hypothesized southern aspects to recovery slower than northern aspects. We also predicted higher burn severity to slow recovery. Field data found attenuated ponderosa pine recovery in hotter and drier regions across all burn severity classes. We concluded that downscaled climate data and Landsat imagery collected at commensurate scales may provide insight into climate effects on post-fire vegetation recovery relevant to ponderosa pine forest managers.

Role of Adsorbed Water on Charge Carrier Dynamics in Photoexcited TiO2

PubMed Central

2017-01-01

Overall photocatalytic water splitting is one of the most sought after processes for sustainable solar-to-chemical energy conversion. The efficiency of this process strongly depends on charge carrier recombination and interaction with surface adsorbates at different time scales. Here, we investigated how hydration of TiO2 P25 affects dynamics of photogenerated electrons at the millisecond to minute time scale characteristic for chemical reactions. We used rapid scan diffuse-reflectance infrared Fourier transform spectroscopy (DRIFTS). The decay of photogenerated electron absorption was substantially slower in the presence of associated water. For hydrated samples, the charge carrier recombination rates followed an Arrhenius-type behavior in the temperature range of 273–423 K; these became temperature-independent when the material was dehydrated at temperatures above 423 K or cooled below 273 K. A DFT+U analysis revealed that hydrogen bonding with adsorbed water stabilizes surface-trapped holes at anatase TiO2(101) facet and lowers the barriers for hole migration. Hence, hole mobility should be higher in the hydrated material than in the dehydrated system. This demonstrates that adsorbed associated water can efficiently stabilize photogenerated charge carriers in nanocrystalline TiO2 and suppress their recombination at the time scale up to minutes. PMID:28413570

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis*

PubMed Central

Kayode, Olumide; Wang, Ruiying; Pendlebury, Devon F.; Cohen, Itay; Henin, Rachel D.; Hockla, Alexandra; Soares, Alexei S.; Papo, Niv; Caulfield, Thomas R.; Radisky, Evette S.

2016-01-01

The molecular basis of enzyme catalytic power and specificity derives from dynamic interactions between enzyme and substrate during catalysis. Although considerable effort has been devoted to understanding how conformational dynamics within enzymes affect catalysis, the role of conformational dynamics within protein substrates has not been addressed. Here, we examine the importance of substrate dynamics in the cleavage of Kunitz-bovine pancreatic trypsin inhibitor protease inhibitors by mesotrypsin, finding that the varied conformational dynamics of structurally similar substrates can profoundly impact the rate of catalysis. A 1.4-Å crystal structure of a mesotrypsin-product complex formed with a rapidly cleaved substrate reveals a dramatic conformational change in the substrate upon proteolysis. By using long all-atom molecular dynamics simulations of acyl-enzyme intermediates with proteolysis rates spanning 3 orders of magnitude, we identify global and local dynamic features of substrates on the nanosecond-microsecond time scale that correlate with enzymatic rates and explain differential susceptibility to proteolysis. By integrating multiple enhanced sampling methods for molecular dynamics, we model a viable conformational pathway between substrate-like and product-like states, linking substrate dynamics on the nanosecond-microsecond time scale with large collective substrate motions on the much slower time scale of catalysis. Our findings implicate substrate flexibility as a critical determinant of catalysis. PMID:27810896

Watching proton transfer in real time: Ultrafast photoionization-induced proton transfer in phenol-ammonia complex cation.

PubMed

Shen, Ching-Chi; Tsai, Tsung-Ting; Wu, Jun-Yi; Ho, Jr-Wei; Chen, Yi-Wei; Cheng, Po-Yuan

2017-10-28

In this paper, we give a full account of our previous work [C. C. Shen et al., J. Chem. Phys. 141, 171103 (2014)] on the study of an ultrafast photoionization-induced proton transfer (PT) reaction in the phenol-ammonia (PhOH-NH 3 ) complex using ultrafast time-resolved ion photofragmentation spectroscopy implemented by the photoionization-photofragmentation pump-probe detection scheme. Neutral PhOH-NH 3 complexes prepared in a free jet are photoionized by femtosecond 1 + 1 resonance-enhanced multiphoton ionization via the S 1 state. The evolving cations are then probed by delayed pulses that result in ion fragmentation, and the ionic dynamics is followed by measuring the parent-ion depletion as a function of the pump-probe delay time. By comparing with systems in which PT is not feasible and the steady-state ion photofragmentation spectra, we concluded that the observed temporal evolutions of the transient ion photofragmentation spectra are consistent with an intracomplex PT reaction after photoionization from the initial non-PT to the final PT structures. Our experiments revealed that PT in [PhOH-NH 3 ] + cation proceeds in two distinct steps: an initial impulsive wave-packet motion in ∼70 fs followed by a slower relaxation of about 1 ps that stabilizes the system into the final PT configuration. These results indicate that for a barrierless PT system, even though the initial PT motions are impulsive and ultrafast, the time scale to complete the reaction can be much slower and is determined by the rate of energy dissipation into other modes.

Watching proton transfer in real time: Ultrafast photoionization-induced proton transfer in phenol-ammonia complex cation

NASA Astrophysics Data System (ADS)

Shen, Ching-Chi; Tsai, Tsung-Ting; Wu, Jun-Yi; Ho-Wei, Jr.; Chen, Yi-Wei; Cheng, Po-Yuan

2017-10-01

In this paper, we give a full account of our previous work [C. C. Shen et al., J. Chem. Phys. 141, 171103 (2014)] on the study of an ultrafast photoionization-induced proton transfer (PT) reaction in the phenol-ammonia (PhOH-NH3) complex using ultrafast time-resolved ion photofragmentation spectroscopy implemented by the photoionization-photofragmentation pump-probe detection scheme. Neutral PhOH-NH3 complexes prepared in a free jet are photoionized by femtosecond 1 + 1 resonance-enhanced multiphoton ionization via the S1 state. The evolving cations are then probed by delayed pulses that result in ion fragmentation, and the ionic dynamics is followed by measuring the parent-ion depletion as a function of the pump-probe delay time. By comparing with systems in which PT is not feasible and the steady-state ion photofragmentation spectra, we concluded that the observed temporal evolutions of the transient ion photofragmentation spectra are consistent with an intracomplex PT reaction after photoionization from the initial non-PT to the final PT structures. Our experiments revealed that PT in [PhOH-NH3]+ cation proceeds in two distinct steps: an initial impulsive wave-packet motion in ˜70 fs followed by a slower relaxation of about 1 ps that stabilizes the system into the final PT configuration. These results indicate that for a barrierless PT system, even though the initial PT motions are impulsive and ultrafast, the time scale to complete the reaction can be much slower and is determined by the rate of energy dissipation into other modes.

Scale invariance of temporal order discrimination using complex, naturalistic events

PubMed Central

Kwok, Sze Chai; Macaluso, Emiliano

2015-01-01

Recent demonstrations of scale invariance in cognitive domains prompted us to investigate whether a scale-free pattern might exist in retrieving the temporal order of events from episodic memory. We present four experiments using an encoding-retrieval paradigm with naturalistic stimuli (movies or video clips). Our studies show that temporal order judgement retrieval times were negatively correlated with the temporal separation between two events in the movie. This relation held, irrespective of whether temporal distances were on the order of tens of minutes (Exp 1−2) or just a few seconds (Exp 3−4). Using the SIMPLE model, we factored in the retention delays between encoding and retrieval (delays of 24 h, 15 min, 1.5–2.5 s, and 0.5 s for Exp 1–4, respectively) and computed a temporal similarity score for each trial. We found a positive relation between similarity and retrieval times; that is, the more temporally similar two events, the slower the retrieval of their temporal order. Using Bayesian analysis, we confirmed the equivalence of the RT/similarity relation across all experiments, which included a vast range of temporal distances and retention delays. These results provide evidence for scale invariance during the retrieval of temporal order of episodic memories. PMID:25909581

Exploring the Links in Monthly to Decadal Variability of the Atmospheric Water Balance Over the Wettest Regions in ERA-20C

NASA Astrophysics Data System (ADS)

Nogueira, M.

2017-10-01

Monthly-to-decadal variability of the regional precipitation over Intertropical Convergence Zone and north-Atlantic and north-Pacific storm tracks was investigated using ERA-20C reanalysis. Satellite-based precipitation (P) and evaporation (E) climatological patterns were well reproduced by ERA-20C. Regional P and E monthly time series displayed 20% differences, but these decreased rapidly with time scale ( 10% at yearly time scales). Spectral analysis showed good scale-by-scale statistical agreement between ERA-20C and observations. Using ERA-Interim showed no improvement despite the much wider range of information assimilated (including satellites). Remarkably high Detrended Cross-Correlation Analysis coefficients (ρDCCA > 0.7 and often ρDCCA > 0.9) revealed tight links between the nonperiodic variability of P, moisture divergence (DIV), and pressure velocity (ω) at monthly-to-decadal time scales over all the wet regions. In contrast, ρDCCA was essentially nonsignificant between nonperiodic P and E or sea surface temperature (SST). Thus, the nonperiodic monthly-to-decadal variability of precipitation in these regions is almost fully controlled by dynamics and not by local E or SST (suggested by Clausius-Clapeyron relation). Analysis of regional nonperiodic standard deviations and power spectra (and respective spectral exponents, β) provided further robustness to this conclusion. Finally, clear transitions in β for P, DIV, and ω between tropical and storm track regions were found. The latter is dominated by transient storms, with energy accumulation at synoptic scales and β < 0.1 at monthly-to-decadal time scales, implying that variability and information creation decrease rapidly with time scale. Larger β values (0.2 to 0.4) were found in the tropics, implying longer-range autocorrelations and slower decreasing variability and information creation with time scale, consistent with the important forcing from internal modes of variability (e.g., El Niño-Southern Oscillation).

Unraveling the electronic relaxation dynamics in photoexcited 2,4-difluoroaniline via femtosecond time-resolved photoelectron imaging

NASA Astrophysics Data System (ADS)

Ling, Fengzi; Li, Shuai; Wei, Jie; Liu, Kai; Wang, Yanmei; Zhang, Bing

2018-04-01

Time-resolved photoelectron imaging is employed to investigate the relaxation dynamics of the lowest two excited electronic states S1(ππ*) and S2(π3s/πσ*) in 2,4-difluoroaniline (24DFA). As the S1(ππ*) state is populated directly following 289 nm excitation, the population undergoes ultrafast intramolecular vibrational redistribution on a 540 fs time scale, followed by efficient intersystem crossing from S1(ππ*) to the triplet state within 379 ps, and the subsequent slower deactivation process of the triplet state. For excitation to the S2(π3s/πσ*) state at 238 nm, the population probably bifurcates into two decay channels. The dominant channel with 84 fs involves ultrafast internal conversion to the S1(ππ*) state, from which it relaxes to the electronic ground state on a 116 ps time scale. The other appears to involve motion along the S2(π3s/πσ*) potential energy surface. Our data also determine experimentally the electronic energies of S2(π3s/πσ*), S3(ππ*), and several Rydberg states in 24DFA.

New Experimental Technique for Nodularity and Mg Fading Control in Compacted Graphite Iron Production on Laboratory Scale

NASA Astrophysics Data System (ADS)

Hernando, Juan Carlos; Domeij, Björn; González, Daniel; Amieva, José Manuel; Diószegi, Attila

2017-11-01

The narrow production window for compacted graphite iron material (CGI) drastically reduces the possibilities to produce it in small batches outside an industrial environment. This fact hinders laboratory-scale investigations on CGI solidification. This work presents a solution to that issue by introducing an experimental technique to produce graphitic cast iron of the main three families. Samples of a base hypereutectic spheroidal graphite iron (SGI) were re-melted in a resistance furnace under Ar atmosphere. Varying the holding time at 1723 K (1450 °C), graphitic irons ranging from spheroidal to lamellar were produced. Characterization of the graphite morphology evolution, in terms of nodularity as a function of holding time, is presented. The nodularity decay for the SGI region suggests a linear correlation with the holding time. In the CGI region, nodularity deterioration shows a slower rate, concluding with the sudden appearance of lamellar graphite. The fading process of magnesium, showing agreement with previous researchers, is described by means of empirical relations as a function of holding time and nodularity. The results on nodularity fade and number of nodules per unit area fade suggest that both phenomena occur simultaneously during the fading process of magnesium.

The Repeated Name Penalty, the Overt Pronoun Penalty, and Topic in Japanese

ERIC Educational Resources Information Center

Shoji, Shinichi; Dubinsky, Stanley; Almor, Amit

2017-01-01

When reading sentences with an anaphoric reference to a subject antecedent, repeated-name anaphors result in slower reading times relative to pronouns (the Repeated Name Penalty: RNP), and overt pronouns are read slower than null pronouns (the Overt Pronoun Penalty: OPP). Because in most languages previously tested, the grammatical subject is…

Analytically Solvable Model of Spreading Dynamics with Non-Poissonian Processes

NASA Astrophysics Data System (ADS)

Jo, Hang-Hyun; Perotti, Juan I.; Kaski, Kimmo; Kertész, János

2014-01-01

Non-Poissonian bursty processes are ubiquitous in natural and social phenomena, yet little is known about their effects on the large-scale spreading dynamics. In order to characterize these effects, we devise an analytically solvable model of susceptible-infected spreading dynamics in infinite systems for arbitrary inter-event time distributions and for the whole time range. Our model is stationary from the beginning, and the role of the lower bound of inter-event times is explicitly considered. The exact solution shows that for early and intermediate times, the burstiness accelerates the spreading as compared to a Poisson-like process with the same mean and same lower bound of inter-event times. Such behavior is opposite for late-time dynamics in finite systems, where the power-law distribution of inter-event times results in a slower and algebraic convergence to a fully infected state in contrast to the exponential decay of the Poisson-like process. We also provide an intuitive argument for the exponent characterizing algebraic convergence.

Characteristic length scales and time-averaged transport velocities of suspended sediment in the mid-Atlantic Region, USA

USGS Publications Warehouse

Pizzuto, James; Schenk, Edward R.; Hupp, Cliff R.; Gellis, Allen; Noe, Greg; Williamson, Elyse; Karwan, Diana L.; O'Neal, Michael; Marquard, Julia; Aalto, Rolf E.; Newbold, Denis

2014-01-01

Watershed Best Management Practices (BMPs) are often designed to reduce loading from particle-borne contaminants, but the temporal lag between BMP implementation and improvement in receiving water quality is difficult to assess because particles are only moved downstream episodically, resting for long periods in storage between transport events. A theory is developed that describes the downstream movement of suspended sediment particles accounting for the time particles spend in storage given sediment budget data (by grain size fraction) and information on particle transit times through storage reservoirs. The theory is used to define a suspended sediment transport length scale that describes how far particles are carried during transport events, and to estimate a downstream particle velocity that includes time spent in storage. At 5 upland watersheds of the mid-Atlantic region, transport length scales for silt-clay range from 4 to 60 km, while those for sand range from 0.4 to 113 km. Mean sediment velocities for silt-clay range from 0.0072 km/yr to 0.12 km/yr, while those for sand range from 0.0008 km/yr to 0.20 km/yr, 4–6 orders of magnitude slower than the velocity of water in the channel. These results suggest lag times of 100–1000 years between BMP implementation and effectiveness in receiving waters such as the Chesapeake Bay (where BMPs are located upstream of the characteristic transport length scale). Many particles likely travel much faster than these average values, so further research is needed to determine the complete distribution of suspended sediment velocities in real watersheds.

Pilot Ed Lewis with T-34C aircraft on ramp

NASA Image and Video Library

1998-03-04

NASA pilot Ed Lewis with the T-34C aircraft on the Dryden Flight Research Center Ramp. The aircraft was previously used at the Lewis Research Center in propulsion experiments involving turboprop engines, and was used as a chase aircraft at Dryden for smaller and slower research projects. Chase aircraft accompany research flights for photography and video purposes, and also as support for safety and research. At Dryden, the T-34 is used mainly for smaller remotely piloted vehicles which fly slower than NASA's F-18's, used for larger scale projects. This aircraft was returned to the U.S. Navy in May of 2002.

Time and metamorphic petrology: Calcite to aragonite experiments

USGS Publications Warehouse

Hacker, B.R.; Kirby, S.H.; Bohlen, S.R.

1992-01-01

Although the equilibrium phase relations of many mineral systems are generally well established, the rates of transformations, particularly in polycrystalline rocks, are not. The results of experiments on the calcite to aragonite transformation in polycrystalline marble are different from those for earlier experiments on powdered and single-crystal calcite. The transformation in the polycrystalline samples occurs by different mechanisms, with a different temperature dependence, and at a markedly slower rate. This work demonstrates the importance of kinetic studies on fully dense polycrystalline aggregates for understanding mineralogic phase changes in nature. Extrapolation of these results to geological time scales suggests that transformation of calcite to aragonite does not occur in the absence of volatiles at temperatures below 200??C. Kinetic hindrance is likely to extend to higher temperatures in more complex transformations.

The Recourse to War: An Appraisal of the ’Weinberger Doctrine’

DTIC Science & Technology

1989-06-01

criteria adapted and clarified defense policies of a different time and a slower world to the exigencies of the present and the chaiienges of the future...coliapse in April 1975 were as profound a shock to the national psyche as any the republic had experienced since the Civil War. IMPACT OF VIETNAM AND...34 It is a historic document; it adapts and clarifies defense policies of a different time and slower world to the exigencies of the present and

Functioning of the Ocean Biological Pump in the Oxygen Minimum Zones

NASA Astrophysics Data System (ADS)

Moore, J. K.

2015-12-01

Oxygen minimum zones occur at mid-depths in the water column in regions with weak ventilation and relatively high export of organic matter from surface waters. They are important ocean for ocean biogeochemistry, and potentially for climate, as sites of water column denitrification and nitrous oxide production. Denitrification is the dominant loss process for fixed nitrogen in the oceans, and can thus affect the ocean inventory of this key nutrient. Denitrification is less energetically efficient than oxic remineralization. Larger zooplankton, which feed on sinking particles, are not present in the lowest oxygen waters. Both of these factors suggest that the remineralization of sinking particles may be slower within the OMZs than in more oxygenated waters. There is limited field evidence and from some modeling studies that remineralization is slower (remineralization length scales are longer) within OMZ waters. In this talk, I will present results from the Community Earth System Model (CESM) ocean component attempting to test this hypothesis. Comparing model results with observed ocean biogeochemical tracer distributions (i.e., phosphate, oxygen), I will examine whether slower remineralization within low oxygen waters provides a better match between simulated and observed tracer distributions. Longer remineralization length scales under low oxygen conditions would provide a negative feedback under global warming scenarios. The biological pump would transfer organic materials to depth more efficiently as ocean oxygen concentrations decline and the OMZs expand.

Real-time monitoring of CO2 storage sites: Application to Illinois Basin-Decatur Project

USGS Publications Warehouse

Picard, G.; Berard, T.; Chabora, E.; Marsteller, S.; Greenberg, S.; Finley, R.J.; Rinck, U.; Greenaway, R.; Champagnon, C.; Davard, J.

2011-01-01

Optimization of carbon dioxide (CO2) storage operations for efficiency and safety requires use of monitoring techniques and implementation of control protocols. The monitoring techniques consist of permanent sensors and tools deployed for measurement campaigns. Large amounts of data are thus generated. These data must be managed and integrated for interpretation at different time scales. A fast interpretation loop involves combining continuous measurements from permanent sensors as they are collected to enable a rapid response to detected events; a slower loop requires combining large datasets gathered over longer operational periods from all techniques. The purpose of this paper is twofold. First, it presents an analysis of the monitoring objectives to be performed in the slow and fast interpretation loops. Second, it describes the implementation of the fast interpretation loop with a real-time monitoring system at the Illinois Basin-Decatur Project (IBDP) in Illinois, USA. ?? 2011 Published by Elsevier Ltd.

Direct and real time probe of photoinduced structure transition in colossal magnetoresistive material

DOE PAGES

Li, Junjie; Wang, Xuan; Zhou, Haidong; ...

2016-07-29

Here, we report a direct and real time measurement of photoinduced structure phase transition in single crystal La 0.84Sr 0.16MnO 3 using femtosecond electron diffraction. The melting of orthorhombic lattice ordering under femtosecond optical excitation is found involving two distinct processes with different time scales, an initial fast melting of orthorhombic phase in about 4 ps and a subsequent slower transformation in 90 ps and longer timescales. Furthermore, the fast process is designated as the initial melting of orthorhombic phase induced by the Mn-O bond change that is most likely driven by the quenching of the dynamic Jahn-Teller distortion followingmore » the photo-excitation. We attribute the slow process to the growing of newly formed structure domain from the photo-excited sites to the neighboring non-excited orthorhombic sites.« less

Aqueous solvation from the water perspective.

PubMed

Ahmed, Saima; Pasti, Andrea; Fernández-Terán, Ricardo J; Ciardi, Gustavo; Shalit, Andrey; Hamm, Peter

2018-06-21

The response of water re-solvating a charge-transfer dye (deprotonated Coumarin 343) after photoexcitation has been measured by means of transient THz spectroscopy. Two steps of increasing THz absorption are observed, a first ∼10 ps step on the time scale of Debye relaxation of bulk water and a much slower step on a 3.9 ns time scale, the latter of which reflecting heating of the bulk solution upon electronic relaxation of the dye molecules from the S 1 back into the S 0 state. As an additional reference experiment, the hydroxyl vibration of water has been excited directly by a short IR pulse, establishing that the THz signal measures an elevated temperature within ∼1 ps. This result shows that the first step upon dye excitation (10 ps) is not limited by the response time of the THz signal; it rather reflects the reorientation of water molecules in the solvation layer. The apparent discrepancy between the relatively slow reorientation time and the general notion that water is among the fastest solvents with a solvation time in the sub-picosecond regime is discussed. Furthermore, non-equilibrium molecular dynamics simulations have been performed, revealing a close-to-quantitative agreement with experiment, which allows one to disentangle the contribution of heating to the overall THz response from that of water orientation.

Cognitive processing speed is related to fall frequency in older adults with multiple sclerosis.

PubMed

Sosnoff, Jacob J; Balantrapu, Swathi; Pilutti, Lara A; Sandroff, Brian M; Morrison, Steven; Motl, Robert W

2013-08-01

To examine mobility, balance, fall risk, and cognition in older adults with multiple sclerosis (MS) as a function of fall frequency. Retrospective, cross-sectional design. University research laboratory. Community-dwelling persons with MS (N=27) aged between 50 and 75 years were divided into 2 groups-single-time (n=11) and recurrent (n=16; >2 falls/12 mo) fallers-on the basis of fall history. Not applicable. Mobility was assessed using a variety of measures including Multiple Sclerosis Walking Scale-12, walking speed (Timed 25-Foot Walk test), endurance (6-Minute Walk test), and functional mobility (Timed Up and Go test). Balance was assessed with the Berg Balance Scale, posturography, and self-reported balance confidence. Fall risk was assessed with the Physiological Profile Assessment. Cognitive processing speed was quantified with the Symbol Digit Modalities Test and the Paced Auditory Serial Addition Test. Recurrent fallers had slower cognitive processing speed than single-time fallers (P ≤.01). There was no difference in mobility, balance, or fall risk between recurrent and single-time fallers (P>.05). Results indicated that cognitive processing speed is associated with fall frequency and may have implications for fall prevention strategies targeting recurrent fallers with MS. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Floquet prethermalization and regimes of heating in a periodically driven, interacting quantum system

NASA Astrophysics Data System (ADS)

Weidinger, Simon A.; Knap, Michael

2017-04-01

We study the regimes of heating in the periodically driven O(N)-model, which is a well established model for interacting quantum many-body systems. By computing the absorbed energy with a non-equilibrium Keldysh Green’s function approach, we establish three dynamical regimes: at short times a single-particle dominated regime, at intermediate times a stable Floquet prethermal regime in which the system ceases to absorb, and at parametrically late times a thermalizing regime. Our simulations suggest that in the thermalizing regime the absorbed energy grows algebraically in time with an exponent that approaches the universal value of 1/2, and is thus significantly slower than linear Joule heating. Our results demonstrate the parametric stability of prethermal states in a many-body system driven at frequencies that are comparable to its microscopic scales. This paves the way for realizing exotic quantum phases, such as time crystals or interacting topological phases, in the prethermal regime of interacting Floquet systems.

Response to ``Comment on `Unified explanation of the anomalous dynamic properties of highly asymmetric polymer blends' '' [J. Chem. Phys. 138, 197101 (2013)

NASA Astrophysics Data System (ADS)

Ngai, K. L.; Capaccioli, S.

2013-05-01

The Comment of Colmenero asserts no change in Fs(Q,t) of the poly(ethylene oxide) (PEO) chains in blends with poly(methyl methacrylate) on crossing times of about 1-2 ns in data obtained by neutron scattering experiments and simulations. The assertion is opposite to that reported in the original papers where the neutron data and simulations were published. To make this point clear, we cite the data and the very statements made in the original papers concluding that indeed in the time interval from 60 ps to 1-2 ns the dynamics of PEO chain follows approximately the Rouse model, but becomes slower and departs from the Rouse model in the dependencies on time, momentum transfer, and temperature at longer times past tc = 1-2 ns. It is noteworthy that similar crossover of chain dynamics in entangled homopolymers at the ns time scale was found by neutron scattering.

Assessing personal financial management in patients with bipolar disorder and its relation to impulsivity and response inhibition.

PubMed

Cheema, Marvi K; MacQueen, Glenda M; Hassel, Stefanie

2015-01-01

Impulsivity and risk-taking behaviours are reported in bipolar disorder (BD). We examined whether financial management skills are related to impulsivity in patients with BD. We assessed financial management skills using the Executive Personal Finance Scale (EPFS), impulsivity using the Barratt Impulsiveness Scale (BIS) and response inhibition using an emotional go/no-go task in bipolar individuals (N = 21) and healthy controls (HC; N = 23). Patients had fewer financial management skills and higher levels of impulsivity than HC. In patients and controls, increased impulsivity was associated with poorer personal financial management. Patients and HC performed equally on the emotional go/no-go task. Higher BIS scores were associated with faster reaction times in HC. In patients, however, higher BIS scores were associated with slower reaction times, possibly indicating compensatory cognitive strategies to counter increased impulsivity. Patients with BD may have reduced abilities to manage personal finances, when compared against healthy participants. Difficulty with personal finance management may arise in part as a result of increased levels of impulsivity. Patients may learn to compensate for increased impulsivity by modulating response times in our experimental situations although whether such compensatory strategies generalize to real-world situations is unknown.

The Magnetic Reconnection Code: an AMR-based fully implicit simulation suite

NASA Astrophysics Data System (ADS)

Germaschewski, K.; Bhattacharjee, A.; Ng, C.-S.

2006-12-01

Extended MHD models, which incorporate two-fluid effects, are promising candidates to enhance understanding of collisionless reconnection phenomena in laboratory, space and astrophysical plasma physics. In this paper, we introduce two simulation codes in the Magnetic Reconnection Code suite which integrate reduced and full extended MHD models. Numerical integration of these models comes with two challenges: Small-scale spatial structures, e.g. thin current sheets, develop and must be well resolved by the code. Adaptive mesh refinement (AMR) is employed to provide high resolution where needed while maintaining good performance. Secondly, the two-fluid effects in extended MHD give rise to dispersive waves, which lead to a very stringent CFL condition for explicit codes, while reconnection happens on a much slower time scale. We use a fully implicit Crank--Nicholson time stepping algorithm. Since no efficient preconditioners are available for our system of equations, we instead use a direct solver to handle the inner linear solves. This requires us to actually compute the Jacobian matrix, which is handled by a code generator that calculates the derivative symbolically and then outputs code to calculate it.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roy, Santanu; Dang, Liem X.

In this paper, we present the first computer simulation of methanol exchange dynamics between the first and second solvation shells around different cations and anions. After water, methanol is the most frequently used solvent for ions. Methanol has different structural and dynamical properties than water, so its ion solvation process is different. To this end, we performed molecular dynamics simulations using polarizable potential models to describe methanol-methanol and ion-methanol interactions. In particular, we computed methanol exchange rates by employing the transition state theory, the Impey-Madden-McDonald method, the reactive flux approach, and the Grote-Hynes theory. We observed that methanol exchange occursmore » at a nanosecond time scale for Na+ and at a picosecond time scale for other ions. We also observed a trend in which, for like charges, the exchange rate is slower for smaller ions because they are more strongly bound to methanol. This work was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences, and Biosciences. The calculations were carried out using computer resources provided by the Office of Basic Energy Sciences.« less

Modelling opinion formation driven communities in social networks

NASA Astrophysics Data System (ADS)

Iñiguez, Gerardo; Barrio, Rafael A.; Kertész, János; Kaski, Kimmo K.

2011-09-01

In a previous paper we proposed a model to study the dynamics of opinion formation in human societies by a co-evolution process involving two distinct time scales of fast transaction and slower network evolution dynamics. In the transaction dynamics we take into account short range interactions as discussions between individuals and long range interactions to describe the attitude to the overall mood of society. The latter is handled by a uniformly distributed parameter α, assigned randomly to each individual, as quenched personal bias. The network evolution dynamics is realised by rewiring the societal network due to state variable changes as a result of transaction dynamics. The main consequence of this complex dynamics is that communities emerge in the social network for a range of values in the ratio between time scales. In this paper we focus our attention on the attitude parameter α and its influence on the conformation of opinion and the size of the resulting communities. We present numerical studies and extract interesting features of the model that can be interpreted in terms of social behaviour.

Particle Acceleration, Magnetic Field Generation, and Emission in Relativistic Pair Jets

NASA Technical Reports Server (NTRS)

Nishikawa, K. I.; Hardee, P.; Hededal, C. B.; Richardson, G.; Sol, H.; Preece, R.; Fishman, G. J.

2004-01-01

Shock acceleration is a ubiquitous phenomenon in astrophysical plasmas. Plasma waves and their associated instabilities (e.g., Buneman, Weibel and other two-stream instabilities) created in collisionless shocks are responsible for particle (electron, positron, and ion) acceleration. Using a 3-D relativistic electromagnetic particle (REMP) code, we have investigated particle acceleration associated with a relativistic jet front propagating into an ambient plasma. We find that the growth times depend on the Lorenz factors of jets. The jets with larger Lorenz factors grow slower. Simulations show that the Weibel instability created in the collisionless shock front accelerates jet and ambient particles both perpendicular and parallel to the jet propagation direction. The small scale magnetic field structure generated by the Weibel instability is appropriate to the generation of "jitter" radiation from deflected electrons (positrons) as opposed to synchrotron radiation. The jitter radiation resulting from small scale magnetic field structures may be important for understanding the complex time structure and spectral evolution observed in gamma-ray bursts or other astrophysical sources containing relativistic jets and relativistic collisionless shocks.

Focused and shifting attention in children with heavy prenatal alcohol exposure.

PubMed

Mattson, Sarah N; Calarco, Katherine E; Lang, Aimée R

2006-05-01

Attention deficits are a hallmark of the teratogenic effects of alcohol. However, characterization of these deficits remains inconclusive. Children with heavy prenatal alcohol exposure and nonexposed controls were evaluated using a paradigm consisting of three conditions: visual focus, auditory focus, and auditory-visual shift of attention. For the focus conditions, participants responded manually to visual or auditory targets. For the shift condition, participants alternated responses between visual targets and auditory targets. For the visual focus condition, alcohol-exposed children had lower accuracy and slower reaction time for all intertarget intervals (ITIs), while on the auditory focus condition, alcohol-exposed children were less accurate but displayed slower reaction time only on the longest ITI. Finally, for the shift condition, the alcohol-exposed group was accurate but had slowed reaction times. These results indicate that children with heavy prenatal alcohol exposure have pervasive deficits in visual focused attention and deficits in maintaining auditory attention over time. However, no deficits were noted in the ability to disengage and reengage attention when required to shift attention between visual and auditory stimuli, although reaction times to shift were slower. Copyright (c) 2006 APA, all rights reserved.

Minor neurological dysfunction in five year old very preterm children is associated with lower processing speed.

PubMed

Kurpershoek, Tinka; Potharst-Sirag, Eva S; Aarnoudse-Moens, Cornelieke S H; van Wassenaer-Leemhuis, Aleid G

2016-12-01

Minor neurological dysfunction (MND) is present in one quarter to one third of children born very preterm (VP). The more severe form, complex (c)-MND has been associated with learning disabilities, behavioural and motor problems. To study the association between c-MND and neurocognitive and motor disabilities at age five in VP children without CP. Ninety-four children born with gestational age<30weeks and/or a birth weight<1000g were assessed at five years corrected age. MND was classified according to Touwen. The Wechsler Preschool and Primary School Scale of Intelligence (WPPSI-III-NL) was used to measure intelligence. Simple reaction time, focused attention and visuomotor coordination were measured using the Amsterdam Neuropsychological Tasks, and working memory using a Digit Span Task. For motor skills the Movement Assessment Battery for children (M-ABC2) was used. Eighty-one percent was classified as 'normal' (no or simple (s-)-MND) and 19% as 'abnormal'(c-MND or mild CP). The abnormal group had a significantly lower processing speed quotient (PSQ), M-ABC percentile score and slower simple Reaction Time than the normal group. Verbal IQ, Performance IQ, working memory, focused attention and visuomotor coordination did not differ between groups. Exclusion of the mild CP cases (n=4) led to similar results. Five year old VP children with c-MND have lower PSQ, slower reaction time, and poorer motor skills, than those without c-MND. Neurological examination should include identification of MND to help identify children at risk for neurocognitive disabilities. Copyright © 2016. Published by Elsevier Ireland Ltd.

Abdominally implanted transmitters with percutaneous antennas affect the dive performance of Common Eiders

USGS Publications Warehouse

Powell, Abby N.; Latty, Christopher J.; Hollmén, Tuula E.; Petersen, Margaret R.; Andrews, Russel D.

2010-01-01

Implanted transmitters have become an important tool for studying the ecology of sea ducks, but their effects remain largely undocumented. To address this, we assessed how abdominally implanted transmitters with percutaneous antennas affect the vertical dive speeds, stroke frequencies, bottom time, and dive duration of captive Common Eiders (Somateria mollissima). To establish baselines, we recorded video of six birds diving 4.9 m prior to surgery, implanted them with 38- to 47-g platform transmitter terminals, and then recorded their diving for 3.5 months after surgery to determine effects. Descent speeds were 16–25% slower and ascent speeds were 17–44% slower after surgery, and both remained below baseline at the end of the study. Dive durations were longer than baseline until day 22. On most days between 15 and 107 days after surgery, foot-stroke frequencies of birds foraging on the bottom were slower. Foot- and wing-stroke frequencies during descent and bottom time did not differ across the time series. If birds that rely on benthic invertebrates for sustenance dive slower and stay submerged longer after being implanted with a satellite transmitter, their foraging energetics may be affected. Researchers considering use of implanted transmitters with percutaneous antennas should be mindful of these effects and the possibility of concomitant alterations in diving behavior, foraging success, and migratory behavior compared to those of unmarked conspecifics.

Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs

PubMed Central

Hübel, Niklas; Dahlem, Markus A.

2014-01-01

The classical Hodgkin-Huxley (HH) model neglects the time-dependence of ion concentrations in spiking dynamics. The dynamics is therefore limited to a time scale of milliseconds, which is determined by the membrane capacitance multiplied by the resistance of the ion channels, and by the gating time constants. We study slow dynamics in an extended HH framework that includes time-dependent ion concentrations, pumps, and buffers. Fluxes across the neuronal membrane change intra- and extracellular ion concentrations, whereby the latter can also change through contact to reservoirs in the surroundings. Ion gain and loss of the system is identified as a bifurcation parameter whose essential importance was not realized in earlier studies. Our systematic study of the bifurcation structure and thus the phase space structure helps to understand activation and inhibition of a new excitability in ion homeostasis which emerges in such extended models. Also modulatory mechanisms that regulate the spiking rate can be explained by bifurcations. The dynamics on three distinct slow times scales is determined by the cell volume-to-surface-area ratio and the membrane permeability (seconds), the buffer time constants (tens of seconds), and the slower backward buffering (minutes to hours). The modulatory dynamics and the newly emerging excitable dynamics corresponds to pathological conditions observed in epileptiform burst activity, and spreading depression in migraine aura and stroke, respectively. PMID:25474648

Beyond the faster-is-slower effect

NASA Astrophysics Data System (ADS)

Sticco, I. M.; Cornes, F. E.; Frank, G. A.; Dorso, C. O.

2017-11-01

The "faster-is-slower" effect arises when crowded people push each other to escape through an exit during an emergency situation. As individuals push harder, a statistical slowing down in the evacuation time can be achieved. The slowing down is caused by the presence of small groups of pedestrians (say, a small human cluster) that temporarily block the way out when trying to leave the room. The pressure on the pedestrians belonging to this blocking cluster increases for increasing anxiety levels and/or a larger number of individuals trying to leave the room through the same door. Our investigation shows, however, that very high pressures alter the dynamics in the blocking cluster and, thus, change the statistics of the time delays along the escaping process. A reduction in the long lasting delays can be acknowledged, while the overall evacuation performance improves. We present results on this phenomenon taking place beyond the faster-is-slower regime.

The Influence of Body Mass on Physical Fitness Test Performance in Male Firefighter Applicants.

PubMed

Phillips, Devin B; Scarlett, Michael P; Petersen, Stewart R

2017-11-01

The influence of body mass on test performance was investigated in 414 male firefighter applicants who completed a maximal treadmill test and five task-simulation tests while dressed in fire protective ensemble. Subjects were assigned to six mass categories from less than 70 kg to more than 110 kg, in 10 kg increments (n = 69 in each). Treadmill performance was lower (P < 0.05) in the two heaviest groups. Charged hose advance time was slower in the two lightest groups. The lightest group had slower times for weighted sled pull, forcible entry, and victim rescue tests. The heaviest group was slower on the ladder climb test. Lighter subjects had a small advantage in endurance-oriented tests while higher mass appeared to improve performance slightly in strength-oriented tests. However, mass explained only 4% to 19% of the variance in performance.

Difficulty with Out-Loud and Silent Reading in Glaucoma

PubMed Central

Ramulu, Pradeep Y.; Swenor, Bonnielin K.; Jefferys, Joan L.; Friedman, David S.; Rubin, Gary S.

2013-01-01

Purpose. We evaluated the impact of glaucoma on out-loud and silent reading. Methods. Glaucoma patients with bilateral visual field (VF) loss and normally-sighted controls had the following parameters measured: speed reading an International Reading Speed Text (IReST) passage out loud, maximum out-loud MNRead chart reading speed, sustained (30 minutes) silent reading speed, and change in reading speed during sustained silent reading. Results. Glaucoma subjects read slower than controls on the IReST (147 vs. 163 words per minute [wpm], P < 0.001), MNRead (172 vs. 186 wpm, P < 0.001), and sustained silent (179 vs. 218 wpm, P < 0.001) tests. In multivariable analyses adjusting for age, race, sex, education, employment, and cognition, IReST and MNRead reading speeds were 12 wpm (6%–7%) slower among glaucoma subjects compared to controls (P < 0.01 for both), while sustained silent reading speed was 16% slower (95% confidence interval [CI] = −24 to −6%, P = 0.002). Each 5 decibel (dB) decrement in better-eye VF mean deviation was associated with 6 wpm slower IReST reading (95% CI = −9 to −3%, P < 0.001), 5 wpm slower MNRead reading (95% CI = −7 to −2%, P < 0.001), and 9% slower sustained silent reading (95% CI = −13 to −6%, P < 0.001). A reading speed decline of 0.5 wpm/min or more over the sustained silent reading period was more common among glaucoma subjects than controls (odds ratio [OR] = 2.2, 95% CI = 1.0–4.9, P < 0.05). Conclusions. Reading speed is slower among glaucoma patients with bilateral VF loss, with the greatest impact present during sustained silent reading. Persons with glaucoma fatigue during silent reading, resulting in slower reading over time. PMID:23074207

Exploring the southern ocean response to climate change

NASA Technical Reports Server (NTRS)

Martinson, Douglas G.; Rind, David; Parkinson, Claire

1993-01-01

The purpose of this project was to couple a regional (Southern Ocean) ocean/sea ice model to the existing Goddard Institute for Space Science (GISS) atmospheric general circulation model (GCM). This modification recognizes: the relative isolation of the Southern Ocean; the need to account, prognostically, for the significant air/sea/ice interaction through all involved components; and the advantage of translating the atmospheric lower boundary (typically the rapidly changing ocean surface) to a level that is consistent with the physical response times governing the system evolution (that is, to the base of the fast responding ocean surface layer). The deeper ocean beneath this layer varies on time scales several orders of magnitude slower than the atmosphere and surface ocean, and therefore the boundary between the upper and deep ocean represents a more reasonable fixed boundary condition.

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis.

PubMed

Kayode, Olumide; Wang, Ruiying; Pendlebury, Devon F; Cohen, Itay; Henin, Rachel D; Hockla, Alexandra; Soares, Alexei S; Papo, Niv; Caulfield, Thomas R; Radisky, Evette S

2016-12-16

The molecular basis of enzyme catalytic power and specificity derives from dynamic interactions between enzyme and substrate during catalysis. Although considerable effort has been devoted to understanding how conformational dynamics within enzymes affect catalysis, the role of conformational dynamics within protein substrates has not been addressed. Here, we examine the importance of substrate dynamics in the cleavage of Kunitz-bovine pancreatic trypsin inhibitor protease inhibitors by mesotrypsin, finding that the varied conformational dynamics of structurally similar substrates can profoundly impact the rate of catalysis. A 1.4-Å crystal structure of a mesotrypsin-product complex formed with a rapidly cleaved substrate reveals a dramatic conformational change in the substrate upon proteolysis. By using long all-atom molecular dynamics simulations of acyl-enzyme intermediates with proteolysis rates spanning 3 orders of magnitude, we identify global and local dynamic features of substrates on the nanosecond-microsecond time scale that correlate with enzymatic rates and explain differential susceptibility to proteolysis. By integrating multiple enhanced sampling methods for molecular dynamics, we model a viable conformational pathway between substrate-like and product-like states, linking substrate dynamics on the nanosecond-microsecond time scale with large collective substrate motions on the much slower time scale of catalysis. Our findings implicate substrate flexibility as a critical determinant of catalysis. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Evaluating the Recovery Curve for Clinically Assessed Reaction Time After Concussion.

PubMed

Del Rossi, Gianluca

2017-08-01

  A change in reaction time is one of various clinical measures of neurocognitive function that can be monitored after concussion and has been reported to be among the most sensitive indicators of cognitive impairment.   To determine the timeline for clinically assessed simple reaction time to return to baseline after a concussion in high school athletes.   Observational study.   Athletic training room.   Twenty-one high school-aged volunteers.   Participants completed 8 trials of the ruler-drop test during each session. Along with baseline measures, a total of 6 additional test sessions were completed over the course of 4 weeks after a concussion (days 3, 7, 10, 14, 21, and 28).   The mean reaction times calculated for all participants from each of the 7 test sessions were analyzed to assess the change in reaction time over the 7 time intervals.   After a concussion and compared with baseline, simple reaction time was, on average, 26 milliseconds slower at 48 to 72 hours postinjury (P < .001), almost 18 milliseconds slower on day 7 (P < .001), and about 9 milliseconds slower on day 10 (P < .001). Simple reaction time did not return to baseline levels until day 14 postinjury.   Clinically assessed simple reaction time appeared to return to baseline levels within a timeframe that mirrors other measures of cognitive performance (approximately 14 days).

Emergent Network Defense

ERIC Educational Resources Information Center

Crane, Earl Newell

2013-01-01

The research problem that inspired this effort is the challenge of managing the security of systems in large-scale heterogeneous networked environments. Human intervention is slow and limited: humans operate at much slower speeds than networked computer communications and there are few humans associated with each network. Enabling each node in the…

Using Ankle Bracing and Taping to Decrease Range of Motion and Velocity During Inversion Perturbation While Walking.

PubMed

Hall, Emily A; Simon, Janet E; Docherty, Carrie L

2016-04-01

Prophylactic ankle supports are commonly used. However, the effectiveness of external supports in preventing an inversion stress has been debated. To evaluate how ankle bracing and taping affect inversion range of motion, time to maximum inversion, inversion velocity, and perceived ankle stability compared with a control condition during a dynamic inversion perturbation while walking. Crossover study. Research laboratory. A total of 42 physically active participants (16 men, 26 women; age = 21.2 ± 3.3 years, height = 168.9 ± 8.9 cm, mass = 66.1 ± 11.4 kg) volunteered. Participants walked on a custom-built walkway that suddenly inverted their ankles to 30° in 3 conditions: brace, tape, and control (no external support). We used an ASO ankle brace for the brace condition and a closed basketweave technique for the tape condition. Three trials were completed for each condition. Main Outcome Measure(s) Maximum inversion (degrees), time to maximum inversion (milliseconds), and inversion velocity (degrees per second) were measured using an electrogoniometer, and perceived stability (centimeters) was measured using a visual analog scale. Maximum inversion decreased more in the brace condition (20.1°) than in the control (25.3°) or tape (22.3°) conditions (both P values = .001), and the tape condition restricted inversion more than the control condition (P = .001). Time to maximum inversion was greater in the brace condition (143.5 milliseconds) than in the control (123.7 milliseconds; P = .001) or tape (130.7 milliseconds; P = .009) conditions and greater in the tape than in the control condition (P = .02). Inversion velocity was slower in the brace condition (142.6°/s) than in the control (209.1°/s) or tape (174.3°/s) conditions (both P values = .001) and slower in the tape than in the control condition (P = .001). Both the brace and tape conditions provided more perceived stability (0.98 cm and 0.94 cm, respectively) than the control condition (2.38 cm; both P values = .001). Both prophylactic conditions affected inversion range of motion, time to maximum inversion, inversion velocity, and perceived ankle stability. However, bracing provided more restriction at a slower rate than taping.

Using Ankle Bracing and Taping to Decrease Range of Motion and Velocity During Inversion Perturbation While Walking

PubMed Central

Hall, Emily A.; Simon, Janet E.; Docherty, Carrie L.

2016-01-01

Context:  Prophylactic ankle supports are commonly used. However, the effectiveness of external supports in preventing an inversion stress has been debated. Objective:  To evaluate how ankle bracing and taping affect inversion range of motion, time to maximum inversion, inversion velocity, and perceived ankle stability compared with a control condition during a dynamic inversion perturbation while walking. Design:  Crossover study. Setting:  Research laboratory. Patients or Other Participants:  A total of 42 physically active participants (16 men, 26 women; age = 21.2 ± 3.3 years, height = 168.9 ± 8.9 cm, mass = 66.1 ± 11.4 kg) volunteered. Intervention(s):  Participants walked on a custom-built walkway that suddenly inverted their ankles to 30° in 3 conditions: brace, tape, and control (no external support). We used an ASO ankle brace for the brace condition and a closed basketweave technique for the tape condition. Three trials were completed for each condition. Main Outcome Measure(s):  Maximum inversion (degrees), time to maximum inversion (milliseconds), and inversion velocity (degrees per second) were measured using an electrogoniometer, and perceived stability (centimeters) was measured using a visual analog scale. Results:  Maximum inversion decreased more in the brace condition (20.1°) than in the control (25.3°) or tape (22.3°) conditions (both P values = .001), and the tape condition restricted inversion more than the control condition (P = .001). Time to maximum inversion was greater in the brace condition (143.5 milliseconds) than in the control (123.7 milliseconds; P = .001) or tape (130.7 milliseconds; P = .009) conditions and greater in the tape than in the control condition (P = .02). Inversion velocity was slower in the brace condition (142.6°/s) than in the control (209.1°/s) or tape (174.3°/s) conditions (both P values = .001) and slower in the tape than in the control condition (P = .001). Both the brace and tape conditions provided more perceived stability (0.98 cm and 0.94 cm, respectively) than the control condition (2.38 cm; both P values = .001). Conclusions:  Both prophylactic conditions affected inversion range of motion, time to maximum inversion, inversion velocity, and perceived ankle stability. However, bracing provided more restriction at a slower rate than taping. PMID:27111586

Vibrational Relaxation and Dynamical Transitions in Atactic Polystyrene

NASA Astrophysics Data System (ADS)

Zhao, Hanqing; Park, Yung; Painter, Paul

2009-03-01

Infrared bands and Raman lines recorded in the frequency domain have a counterpart in the time domain in the form of time-correlation functions, which are sensitive to molecular dynamics on the picosecond time scale. This is explored by calculating time correlation functions and their variation with temperature for the conformationally insensitive modes observed near 1601 cm-1 and 1583 cm-1 in the infrared spectrum of atactic polystyrene. The correlation functions were modeled by assuming that there is a fast relaxation process characterized by a single relaxation time that is inhomogeneously broadened by a slower process, also characterized by a single relaxation time. The fundamental mode, near 1583 cm-1, is inhomogeneously broadened, but the relaxation time calculated for this mode is sensitive to temperature as a result of anharmonic coupling to a combination mode. A change in the modulation of the 1583 cm-1 band becomes apparent about 10--20 degrees below the thermally measured Tg. Relaxation times at first increase then decrease and becomes negligible at temperatures near 180 degrees. These results are consistent with theories of the glass transition.

Efficient coarse simulation of a growing avascular tumor

PubMed Central

Kavousanakis, Michail E.; Liu, Ping; Boudouvis, Andreas G.; Lowengrub, John; Kevrekidis, Ioannis G.

2013-01-01

The subject of this work is the development and implementation of algorithms which accelerate the simulation of early stage tumor growth models. Among the different computational approaches used for the simulation of tumor progression, discrete stochastic models (e.g., cellular automata) have been widely used to describe processes occurring at the cell and subcell scales (e.g., cell-cell interactions and signaling processes). To describe macroscopic characteristics (e.g., morphology) of growing tumors, large numbers of interacting cells must be simulated. However, the high computational demands of stochastic models make the simulation of large-scale systems impractical. Alternatively, continuum models, which can describe behavior at the tumor scale, often rely on phenomenological assumptions in place of rigorous upscaling of microscopic models. This limits their predictive power. In this work, we circumvent the derivation of closed macroscopic equations for the growing cancer cell populations; instead, we construct, based on the so-called “equation-free” framework, a computational superstructure, which wraps around the individual-based cell-level simulator and accelerates the computations required for the study of the long-time behavior of systems involving many interacting cells. The microscopic model, e.g., a cellular automaton, which simulates the evolution of cancer cell populations, is executed for relatively short time intervals, at the end of which coarse-scale information is obtained. These coarse variables evolve on slower time scales than each individual cell in the population, enabling the application of forward projection schemes, which extrapolate their values at later times. This technique is referred to as coarse projective integration. Increasing the ratio of projection times to microscopic simulator execution times enhances the computational savings. Crucial accuracy issues arising for growing tumors with radial symmetry are addressed by applying the coarse projective integration scheme in a cotraveling (cogrowing) frame. As a proof of principle, we demonstrate that the application of this scheme yields highly accurate solutions, while preserving the computational savings of coarse projective integration. PMID:22587128

Drosophila embryogenesis scales uniformly across temperature in developmentally diverse species.

PubMed

Kuntz, Steven G; Eisen, Michael B

2014-04-01

Temperature affects both the timing and outcome of animal development, but the detailed effects of temperature on the progress of early development have been poorly characterized. To determine the impact of temperature on the order and timing of events during Drosophila melanogaster embryogenesis, we used time-lapse imaging to track the progress of embryos from shortly after egg laying through hatching at seven precisely maintained temperatures between 17.5 °C and 32.5 °C. We employed a combination of automated and manual annotation to determine when 36 milestones occurred in each embryo. D. melanogaster embryogenesis takes [Formula: see text]33 hours at 17.5 °C, and accelerates with increasing temperature to a low of 16 hours at 27.5 °C, above which embryogenesis slows slightly. Remarkably, while the total time of embryogenesis varies over two fold, the relative timing of events from cellularization through hatching is constant across temperatures. To further explore the relationship between temperature and embryogenesis, we expanded our analysis to cover ten additional Drosophila species of varying climatic origins. Six of these species, like D. melanogaster, are of tropical origin, and embryogenesis time at different temperatures was similar for them all. D. mojavensis, a sub-tropical fly, develops slower than the tropical species at lower temperatures, while D. virilis, a temperate fly, exhibits slower development at all temperatures. The alpine sister species D. persimilis and D. pseudoobscura develop as rapidly as tropical flies at cooler temperatures, but exhibit diminished acceleration above 22.5 °C and have drastically slowed development by 30 °C. Despite ranging from 13 hours for D. erecta at 30 °C to 46 hours for D. virilis at 17.5 °C, the relative timing of events from cellularization through hatching is constant across all species and temperatures examined here, suggesting the existence of a previously unrecognized timer controlling the progress of embryogenesis that has been tuned by natural selection as each species diverges.

Selective control of small versus large diameter axons using infrared laser light (Conference Presentation)

NASA Astrophysics Data System (ADS)

Lothet, Emilie H.; Shaw, Kendrick M.; Horn, Charles C.; Lu, Hui; Wang, Yves T.; Jansen, E. Duco; Chiel, Hillel J.; Jenkins, Michael W.

2016-03-01

Sensory information is conveyed to the central nervous system via small diameter unmyelinated fibers. In general, smaller diameter axons have slower conduction velocities. Selective control of such fibers could create new clinical treatments for chronic pain, nausea in response to chemo-therapeutic agents, or hypertension. Electrical stimulation can control axonal activity, but induced axonal current is proportional to cross-sectional area, so that large diameter fibers are affected first. Physiologically, however, synaptic inputs generally affect small diameter fibers before large diameter fibers (the size principle). A more physiological modality that first affected small diameter fibers could have fewer side effects (e.g., not recruiting motor axons). A novel mathematical analysis of the cable equation demonstrates that the minimum length along the axon for inducing block scales with the square root of axon diameter. This implies that the minimum length along an axon for inhibition will scale as the square root of axon diameter, so that lower radiant exposures of infrared light will selectively affect small diameter, slower conducting fibers before those of large diameter. This prediction was tested in identified neurons from the marine mollusk Aplysia californica. Radiant exposure to block a neuron with a slower conduction velocity (B43) was consistently lower than that needed to block a faster conduction velocity neuron (B3). Furthermore, in the vagus nerve of the musk shrew, lower radiant exposure blocked slow conducting fibers before blocking faster conducting fibers. Infrared light can selectively control smaller diameter fibers, suggesting many novel clinical treatments.

Temporal precision in the visual pathway through the interplay of excitation and stimulus-driven suppression.

PubMed

Butts, Daniel A; Weng, Chong; Jin, Jianzhong; Alonso, Jose-Manuel; Paninski, Liam

2011-08-03

Visual neurons can respond with extremely precise temporal patterning to visual stimuli that change on much slower time scales. Here, we investigate how the precise timing of cat thalamic spike trains-which can have timing as precise as 1 ms-is related to the stimulus, in the context of both artificial noise and natural visual stimuli. Using a nonlinear modeling framework applied to extracellular data, we demonstrate that the precise timing of thalamic spike trains can be explained by the interplay between an excitatory input and a delayed suppressive input that resembles inhibition, such that neuronal responses only occur in brief windows where excitation exceeds suppression. The resulting description of thalamic computation resembles earlier models of contrast adaptation, suggesting a more general role for mechanisms of contrast adaptation in visual processing. Thus, we describe a more complex computation underlying thalamic responses to artificial and natural stimuli that has implications for understanding how visual information is represented in the early stages of visual processing.

Improved spatial resolution for U-series dating of opal at Yucca Mountain, Nevada, USA, using ion-microprobe and microdigestion methods

USGS Publications Warehouse

Paces, J.B.; Neymark, L.A.; Wooden, J.L.; Persing, H.M.

2004-01-01

Two novel methods of in situ isotope analysis, ion microprobe and microdigestion, were used for 230Th/U and 234U/238U dating of finely laminated opal hemispheres formed in unsaturated felsic tuff at Yucca Mountain, Nevada, proposed site for a high-level radioactive waste repository. Both methods allow analysis of layers as many as several orders of magnitude thinner than standard methods using total hemisphere digestion that were reported previously. Average growth rates calculated from data at this improved spatial resolution verified that opal grew at extremely slow rates over the last million years. Growth rates of 0.58 and 0.69 mm/m.y. were obtained for the outer 305 and 740 ??m of two opal hemispheres analyzed by ion microprobe, and 0.68 mm/m.y. for the outer 22 ??m of one of these same hemispheres analyzed by sequential microdigestion. These Pleistocene growth rates are 2 to 10 times slower than those calculated for older secondary calcite and silica mineral coatings deposited over the last 5 to 10 m.y. dated by the U-Pb method and may reflect differences between Miocene and Pleistocene seepage flux. The microdigestion data also imply that opal growth rates may have varied over the last 40 k.y. These data are the first indication that growth rates and associated seepage in the proposed repository horizon may correlate with changes in late Pleistocene climate, involving faster growth during wetter, cooler climates (glacial maximum), slower growth during transition climates, and no growth during the most arid climate (modern). Data collected at this refined spatial scale may lead to a better understanding of the hydrologic variability expected within the thick unsaturated zone at Yucca Mountain over the time scale of interest for radioactive waste isolation. ?? 2004 Elsevier Ltd.

Use of ruthenium dyes for subnanosecond detector fidelity testing in real time transient absorption

NASA Astrophysics Data System (ADS)

Byrdin, Martin; Thiagarajan, Viruthachalam; Villette, Sandrine; Espagne, Agathe; Brettel, Klaus

2009-04-01

Transient absorption spectroscopy is a powerful tool for the study of photoreactions on time scales from femtoseconds to seconds. Typically, reactions slower than ˜1 ns are recorded by the "classical" technique; the reaction is triggered by an excitation flash, and absorption changes accompanying the reaction are recorded in real time using a continuous monitoring light beam and a detection system with sufficiently fast response. The pico- and femtosecond region can be accessed by the more recent "pump-probe" technique, which circumvents the difficulties of real time detection on a subnanosecond time scale. This is paid for by accumulation of an excessively large number of shots to sample the reaction kinetics. Hence, it is of interest to extend the classical real time technique as far as possible to the subnanosecond range. In order to identify and minimize detection artifacts common on a subnanosecond scale, like overshoot, ringing, and signal reflections, rigorous testing is required of how the detection system responds to fast changes of the monitoring light intensity. Here, we introduce a novel method to create standard signals for detector fidelity testing on a time scale from a few picoseconds to tens of nanoseconds. The signals result from polarized measurements of absorption changes upon excitation of ruthenium complexes {[Ru(bpy)3]2+ and a less symmetric derivative} by a short laser flash. Two types of signals can be created depending on the polarization of the monitoring light with respect to that of the excitation flash: a fast steplike bleaching at magic angle and a monoexponentially decaying bleaching for parallel polarizations. The lifetime of the decay can be easily varied via temperature and viscosity of the solvent. The method is applied to test the performance of a newly developed real time transient absorption setup with 300 ps time resolution and high sensitivity.

Injury rates and injury risk factors among Federal Bureau of Investigation new agent trainees.

PubMed

Knapik, Joseph J; Grier, Tyson; Spiess, Anita; Swedler, David I; Hauret, Keith G; Graham, Bria; Yoder, James; Jones, Bruce H

2011-12-13

A one-year prospective examination of injury rates and injury risk factors was conducted in Federal Bureau of Investigation (FBI) new agent training. Injury incidents were obtained from medical records and injury compensation forms. Potential injury risk factors were acquired from a lifestyle questionnaire and existing data at the FBI Academy. A total of 426 men and 105 women participated in the project. Thirty-five percent of men and 42% of women experienced one or more injuries during training. The injury incidence rate was 2.5 and 3.2 injuries/1,000 person-days for men and women, respectively (risk ratio (women/men) = 1.3, 95% confidence interval = 0.9-1.7). The activities most commonly associated with injuries (% of total) were defensive tactics training (58%), physical fitness training (20%), physical fitness testing (5%), and firearms training (3%). Among the men, higher injury risk was associated with older age, slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the physical fitness test (PFT), lower self-rated physical activity, lower frequency of aerobic exercise, a prior upper or lower limb injury, and prior foot or knee pain that limited activity. Among the women higher injury risk was associated with slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the PFT, and prior back pain that limited activity. The results of this investigation supported those of a previous retrospective investigation emphasizing that lower fitness and self-reported pain limiting activity were associated with higher injury risk among FBI new agents.

Effect of nitrogen seeding on the energy losses and on the time scales of the electron temperature and density collapse of type-I ELMs in JET with the ITER-like wall

NASA Astrophysics Data System (ADS)

Frassinetti, L.; Dodt, D.; Beurskens, M. N. A.; Sirinelli, A.; Boom, J. E.; Eich, T.; Flanagan, J.; Giroud, C.; Jachmich, M. S.; Kempenaars, M.; Lomas, P.; Maddison, G.; Maggi, C.; Neu, R.; Nunes, I.; Perez von Thun, C.; Sieglin, B.; Stamp, M.; Contributors, JET-EFDA

2015-02-01

The baseline type-I ELMy H-mode scenario has been re-established in JET with the new tungsten MKII-HD divertor and beryllium on the main wall (hereafter called the ITER-like wall, JET-ILW). The first JET-ILW results show that the confinement is degraded by 20-30% in the baseline scenarios compared to the previous carbon wall JET (JET-C) plasmas. The degradation is mainly driven by the reduction in the pedestal temperature. Stored energies and pedestal temperature comparable to the JET-C have been obtained to date in JET-ILW baseline plasmas only in the high triangularity shape using N2 seeding. This work compares the energy losses during ELMs and the corresponding time scales of the temperature and density collapse in JET-ILW baseline plasmas with and without N2 seeding with similar JET-C baseline plasmas. ELMs in the JET-ILW differ from those with the carbon wall both in terms of time scales and energy losses. The ELM time scale, defined as the time to reach the minimum pedestal temperature soon after the ELM collapse, is ˜2 ms in the JET-ILW and lower than 1 ms in the JET-C. The energy losses are in the range ΔWELM/Wped ≈ 7-12% in the JET-ILW and ΔWELM/Wped ≈ 10-20% in JET-C, and fit relatively well with earlier multi-machine empirical scalings of ΔWELM/Wped with collisionality. The time scale of the ELM collapse seems to be related to the pedestal collisionality. Most of the non-seeded JET-ILW ELMs are followed by a further energy drop characterized by a slower time scale ˜8-10 ms (hereafter called slow transport events), that can lead to losses in the range ΔWslow/Wped ≈ 15-22%, slightly larger than the losses in JET-C. The N2 seeding in JET-ILW significantly affects the ELMs. The JET-ILW plasmas with N2 seeding are characterized by ELM energy losses and time scales similar to the JET-C and by the absence of the slow transport events.

Aberration-Corrected Electron Beam Lithography at the One Nanometer Length Scale

DOE PAGES

Manfrinato, Vitor R.; Stein, Aaron; Zhang, Lihua; ...

2017-04-18

Patterning materials efficiently at the smallest length scales has been a longstanding challenge in nanotechnology. Electron-beam lithography (EBL) is the primary method for patterning arbitrary features, but EBL has not reliably provided sub-4 nm patterns. The few competing techniques that have achieved this resolution are orders of magnitude slower than EBL. In this work, we employed an aberration-corrected scanning transmission electron microscope for lithography to achieve unprecedented resolution. Here we show aberration-corrected EBL at the one nanometer length scale using poly(methyl methacrylate) (PMMA) and have produced both the smallest isolated feature in any conventional resist (1.7 ± 0.5 nm) andmore » the highest density patterns in PMMA (10.7 nm pitch for negative-tone and 17.5 nm pitch for positive-tone PMMA). We also demonstrate pattern transfer from the resist to semiconductor and metallic materials at the sub-5 nm scale. These results indicate that polymer-based nanofabrication can achieve feature sizes comparable to the Kuhn length of PMMA and ten times smaller than its radius of gyration. Use of aberration-corrected EBL will increase the resolution, speed, and complexity in nanomaterial fabrication.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manfrinato, Vitor R.; Stein, Aaron; Zhang, Lihua

Patterning materials efficiently at the smallest length scales has been a longstanding challenge in nanotechnology. Electron-beam lithography (EBL) is the primary method for patterning arbitrary features, but EBL has not reliably provided sub-4 nm patterns. The few competing techniques that have achieved this resolution are orders of magnitude slower than EBL. In this work, we employed an aberration-corrected scanning transmission electron microscope for lithography to achieve unprecedented resolution. Here we show aberration-corrected EBL at the one nanometer length scale using poly(methyl methacrylate) (PMMA) and have produced both the smallest isolated feature in any conventional resist (1.7 ± 0.5 nm) andmore » the highest density patterns in PMMA (10.7 nm pitch for negative-tone and 17.5 nm pitch for positive-tone PMMA). We also demonstrate pattern transfer from the resist to semiconductor and metallic materials at the sub-5 nm scale. These results indicate that polymer-based nanofabrication can achieve feature sizes comparable to the Kuhn length of PMMA and ten times smaller than its radius of gyration. Use of aberration-corrected EBL will increase the resolution, speed, and complexity in nanomaterial fabrication.« less

Faster Increases in Human Life Expectancy Could Lead to Slower Population Aging

PubMed Central

2015-01-01

Counterintuitively, faster increases in human life expectancy could lead to slower population aging. The conventional view that faster increases in human life expectancy would lead to faster population aging is based on the assumption that people become old at a fixed chronological age. A preferable alternative is to base measures of aging on people’s time left to death, because this is more closely related to the characteristics that are associated with old age. Using this alternative interpretation, we show that faster increases in life expectancy would lead to slower population aging. Among other things, this finding affects the assessment of the speed at which countries will age. PMID:25876033

Graphene: corrosion-inhibiting coating.

PubMed

Prasai, Dhiraj; Tuberquia, Juan Carlos; Harl, Robert R; Jennings, G Kane; Rogers, Bridget R; Bolotin, Kirill I

2012-02-28

We report the use of atomically thin layers of graphene as a protective coating that inhibits corrosion of underlying metals. Here, we employ electrochemical methods to study the corrosion inhibition of copper and nickel by either growing graphene on these metals, or by mechanically transferring multilayer graphene onto them. Cyclic voltammetry measurements reveal that the graphene coating effectively suppresses metal oxidation and oxygen reduction. Electrochemical impedance spectroscopy measurements suggest that while graphene itself is not damaged, the metal under it is corroded at cracks in the graphene film. Finally, we use Tafel analysis to quantify the corrosion rates of samples with and without graphene coatings. These results indicate that copper films coated with graphene grown via chemical vapor deposition are corroded 7 times slower in an aerated Na(2)SO(4) solution as compared to the corrosion rate of bare copper. Tafel analysis reveals that nickel with a multilayer graphene film grown on it corrodes 20 times slower while nickel surfaces coated with four layers of mechanically transferred graphene corrode 4 times slower than bare nickel. These findings establish graphene as the thinnest known corrosion-protecting coating.

Subjective expansion of extended time-spans in experienced meditators.

PubMed

Wittmann, Marc; Otten, Simone; Schötz, Eva; Sarikaya, Anna; Lehnen, Hanna; Jo, Han-Gue; Kohls, Niko; Schmidt, Stefan; Meissner, Karin

2014-01-01

Experienced meditators typically report that they experience time slowing down in meditation practice as well as in everyday life. Conceptually this phenomenon may be understood through functional states of mindfulness, i.e., by attention regulation, body awareness, emotion regulation, and enhanced memory. However, hardly any systematic empirical work exists regarding the experience of time in meditators. In the current cross-sectional study, we investigated whether 42 experienced mindfulness meditation practitioners (with on average 10 years of experience) showed differences in the experience of time as compared to 42 controls without any meditation experience matched for age, sex, and education. The perception of time was assessed with a battery of psychophysical tasks assessing the accuracy of prospective time judgments in duration discrimination, duration reproduction, and time estimation in the milliseconds to minutes range as well with several psychometric instruments related to subjective time such as the Zimbardo Time Perspective Inventory, the Barratt Impulsivity Scale and the Freiburg Mindfulness Inventory. In addition, subjective time judgments on the current passage of time and retrospective time ranges were assessed. While subjective judgements of time were found to be significantly different between the two groups on several scales, no differences in duration estimates in the psychophysical tasks were detected. Regarding subjective time, mindfulness meditators experienced less time pressure, more time dilation, and a general slower passage of time. Moreover, they felt that the last week and the last month passed more slowly. Overall, although no intergroup differences in psychophysical tasks were detected, the reported findings demonstrate a close association between mindfulness meditation and the subjective feeling of the passage of time captured by psychometric instruments.

T-34C in flight

NASA Image and Video Library

1997-03-21

A NASA T-34C aircraft, used for safety chase, is shown flying above the Dryden Flight Research Center, Edwards, California in March 1997. The aircraft was previously used at the Lewis Research Center in propulsion experiments involving turboprop engines, and was used as a chase aircraft at Dryden for smaller and slower research projects. Chase aircraft accompany research flights for photography and video purposes, and also as support for safety and research. At Dryden, the T-34 is used mainly for smaller remotely piloted vehicles which fly slower than NASA's F-18's, used for larger scale projects. This aircraft was returned to the U.S. Navy in May of 2002. The T-34C, built by Beech, carries a crew of 2 and is nicknamed the Mentor.

Pilot-in-the-Loop CFD Method Development

DTIC Science & Technology

2017-04-20

the methods on the NAVAIR Manned Flight Simulator. Activities this period During this report period, we implemented the CRAFT CFD code on the...Penn State VLRCROE Flight simulator and performed the first Pilot-in-the-Loop PILCFD tests at Penn State using the COCOA5 clusters. The initial tests...integration of the flight simulator and Penn State computing infrastructure. Initial tests showed slower performance than real-time (3x slower than real

Subliminal semantic priming in speech.

PubMed

Daltrozzo, Jérôme; Signoret, Carine; Tillmann, Barbara; Perrin, Fabien

2011-01-01

Numerous studies have reported subliminal repetition and semantic priming in the visual modality. We transferred this paradigm to the auditory modality. Prime awareness was manipulated by a reduction of sound intensity level. Uncategorized prime words (according to a post-test) were followed by semantically related, unrelated, or repeated target words (presented without intensity reduction) and participants performed a lexical decision task (LDT). Participants with slower reaction times in the LDT showed semantic priming (faster reaction times for semantically related compared to unrelated targets) and negative repetition priming (slower reaction times for repeated compared to semantically related targets). This is the first report of semantic priming in the auditory modality without conscious categorization of the prime.

Subliminal Semantic Priming in Speech

PubMed Central

Tillmann, Barbara; Perrin, Fabien

2011-01-01

Numerous studies have reported subliminal repetition and semantic priming in the visual modality. We transferred this paradigm to the auditory modality. Prime awareness was manipulated by a reduction of sound intensity level. Uncategorized prime words (according to a post-test) were followed by semantically related, unrelated, or repeated target words (presented without intensity reduction) and participants performed a lexical decision task (LDT). Participants with slower reaction times in the LDT showed semantic priming (faster reaction times for semantically related compared to unrelated targets) and negative repetition priming (slower reaction times for repeated compared to semantically related targets). This is the first report of semantic priming in the auditory modality without conscious categorization of the prime. PMID:21655277

Five different tests of reaction time evaluated in HIV seropositive men.

PubMed

Dunlop, O; Bjørklund, R A; Abdelnoor, M; Myrvang, B

1992-09-01

In an attempt to develop a short neuropsychological test battery five different tests of reaction time were assessed according to their ability to discriminate between HIV seropositive men and healthy controls. In all tests a patient group with clinical symptoms was slower than the control group. In the complex reaction time test, which has a large cognitive aspect, even a clinically "asymptomatic" group was slower than the control group. The movement test, a new test with a large motor component, identified most slow responders, defining approximately half of the patients with clinical symptoms and one third of the "asymptomatic" patients as such. A test battery consisting of three tests is suggested for serial assessment and screening.

Submovement control processes in discrete aiming as a function of space-time constraints.

PubMed

Hsieh, Tsung-Yu; Liu, Yeou-Teh; Newell, Karl M

2017-01-01

There is preliminary evidence that there are several types of submovements in movement aiming that reflect different processes of control and can result from particular task constraints. The purpose of the study was to investigate the effect of movement space and time task criteria on the prevalence of different submovement control characteristics in discrete aiming. Twelve participants completed 3 distance x 5 time conditions each with 100 trials in a target-aiming movement task. The kinematic structure of the trajectory determined the prevalence of 5 submovement types (none; pre-peak, post-peak movement velocity; undershoot, overshoot). The findings showed that the overall number of submovements increased in the slower space-time conditions and was predominantly characterized by post-peak trajectory submovements rather than discrete overshoot submovements. Overshoot submovements were more frequent in the high average movement velocity and short time duration conditions. We concluded that there are qualitatively different distributional patterns of submovement types in discrete aiming tasks that are organized by the quantitative scaling of the average movement velocity arising from multiple control processes to meet the specific space-time task constraints.

Grain-Size-Limited Mobility in Methylammonium Lead Iodide Perovskite Thin Films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reid, Obadiah G.; Yang, Mengjin; Kopidakis, Nikos

2016-09-09

We report a systematic study of the gigahertz-frequency charge carrier mobility found in methylammonium lead iodide perovskite films as a function of average grain size using time-resolved microwave conductivity and a single processing chemistry. Our measurements are in good agreement with the Kubo formula for the AC mobility of charges confined within finite grains, suggesting (1) that the surface grains imaged via scanning electron microscopy are representative of the true electronic domain size and not substantially subdivided by twinning or other defects not visible by microscopy and (2) that the time scale of diffusive transport across grain boundaries is muchmore » slower than the period of the microwave field in this measurement (-100 ps). The intrinsic (infinite grain size) minimum mobility extracted form the model is 29 +/- 6 cm2 V-1 s-1 at the probe frequency (8.9 GHz).« less

Exploring compression techniques for ROOT IO

NASA Astrophysics Data System (ADS)

Zhang, Z.; Bockelman, B.

2017-10-01

ROOT provides an flexible format used throughout the HEP community. The number of use cases - from an archival data format to end-stage analysis - has required a number of tradeoffs to be exposed to the user. For example, a high “compression level” in the traditional DEFLATE algorithm will result in a smaller file (saving disk space) at the cost of slower decompression (costing CPU time when read). At the scale of the LHC experiment, poor design choices can result in terabytes of wasted space or wasted CPU time. We explore and attempt to quantify some of these tradeoffs. Specifically, we explore: the use of alternate compressing algorithms to optimize for read performance; an alternate method of compressing individual events to allow efficient random access; and a new approach to whole-file compression. Quantitative results are given, as well as guidance on how to make compression decisions for different use cases.

Intramolecular vibrational energy redistribution and intermolecular energy transfer of benzene in supercritical CO 2: measurements from the gas phase up to liquid densities

NASA Astrophysics Data System (ADS)

von Benten, R.; Charvat, A.; Link, O.; Abel, B.; Schwarzer, D.

2004-03-01

Femtosecond pump probe spectroscopy was employed to measure intramolecular vibrational energy redistribution (IVR) and intermolecular vibrational energy transfer (VET) of benzene in the gas phase and in supercritical (sc) CO 2. We observe two IVR time scales the faster of which proceeds within τ IVR(1)<0.5 ps. The slower IVR component has a time constant of τ IVR(2)=(48±5) ps in the gas phase and in scCO 2 is accelerated by interactions with the solvent. At the highest CO 2 density it is reduced to τ IVR(2)=(6±1) ps. The corresponding IVR rate constants show a similar density dependence as the VET rate constants. Model calculations suggest that both quantities correlate with the local CO 2 density in the immediate surrounding of the benzene molecule.

Relaxation dynamics and transformation kinetics of deeply supercooled water: Temperature, pressure, doping, and proton/deuteron isotope effects.

PubMed

Lemke, Sonja; Handle, Philip H; Plaga, Lucie J; Stern, Josef N; Seidl, Markus; Fuentes-Landete, Violeta; Amann-Winkel, Katrin; Köster, Karsten W; Gainaru, Catalin; Loerting, Thomas; Böhmer, Roland

2017-07-21

Above its glass transition, the equilibrated high-density amorphous ice (HDA) transforms to the low-density pendant (LDA). The temperature dependence of the transformation is monitored at ambient pressure using dielectric spectroscopy and at elevated pressures using dilatometry. It is found that near the glass transition temperature of deuterated samples, the transformation kinetics is 300 times slower than the structural relaxation, while for protonated samples, the time scale separation is at least 30 000 and insensitive to doping. The kinetics of the HDA to LDA transformation lacks a proton/deuteron isotope effect, revealing that this process is dominated by the restructuring of the oxygen network. The x-ray diffraction experiments performed on samples at intermediate transition stages reflect a linear combination of the LDA and HDA patterns implying a macroscopic phase separation, instead of a local intermixing of the two amorphous states.

Proof of concept of a novel SMA cage actuator

NASA Astrophysics Data System (ADS)

Deyer, Christopher W.; Brei, Diann E.

2001-06-01

Numerous industrial applications that currently utilize expensive solenoids or slow wax motors are good candidates for smart material actuation. Many of these applications require millimeter-scale displacement and low cost; thereby, eliminating piezoelectric technologies. Fortunately, there is a subset of these applications that can tolerate the slower response of shape memory alloys. This paper details a proof-of-concept study of a novel SMA cage actuator intended for proportional braking in commercial appliances. The chosen actuator architecture consists of a SMA wire cage enclosing a return spring. To develop an understanding of the influences of key design parameters on the actuator response time and displacement amplitude, a half-factorial 25 Design of Experiment (DOE) study was conducted utilizing eight differently configured prototypes. The DOE results guided the selection of the design parameters for the final proof-of-concept actuator. This actuator was built and experimentally characterized for stroke, proportional control and response time.

Induced mood and selective attention.

PubMed

Brand, N; Verspui, L; Oving, A

1997-04-01

Subjects (N = 60) were randomly assigned to an elated, depressed, or neutral mood-induction condition to assess the effect of mood state on cognitive functioning. In the elated condition film fragments expressing happiness and euphoria were shown. In the depressed condition some frightening and distressing film fragments were presented. The neutral group watched no film. Mood states were measured using the Profile of Mood States, and a Stroop task assessed selective attention. Both were presented by computer. The induction groups differed significantly in the expected direction on the mood subscales Anger, Tension, Depression, Vigour, and Fatigue, and also in the mean scale response times, i.e., slower responses for the depressed condition and faster for the elated one. Differences between conditions were found in the errors on the Stroop: in the depressed condition were the fewest errors and significantly longer error reaction times. Speed of error was associated with self-reported fatigue.

Relaxation dynamics and transformation kinetics of deeply supercooled water: Temperature, pressure, doping, and proton/deuteron isotope effects

NASA Astrophysics Data System (ADS)

Lemke, Sonja; Handle, Philip H.; Plaga, Lucie J.; Stern, Josef N.; Seidl, Markus; Fuentes-Landete, Violeta; Amann-Winkel, Katrin; Köster, Karsten W.; Gainaru, Catalin; Loerting, Thomas; Böhmer, Roland

2017-07-01

Above its glass transition, the equilibrated high-density amorphous ice (HDA) transforms to the low-density pendant (LDA). The temperature dependence of the transformation is monitored at ambient pressure using dielectric spectroscopy and at elevated pressures using dilatometry. It is found that near the glass transition temperature of deuterated samples, the transformation kinetics is 300 times slower than the structural relaxation, while for protonated samples, the time scale separation is at least 30 000 and insensitive to doping. The kinetics of the HDA to LDA transformation lacks a proton/deuteron isotope effect, revealing that this process is dominated by the restructuring of the oxygen network. The x-ray diffraction experiments performed on samples at intermediate transition stages reflect a linear combination of the LDA and HDA patterns implying a macroscopic phase separation, instead of a local intermixing of the two amorphous states.

Vibrational energy flow controls internal conversion in a transition metal complex.

PubMed

Hedley, Gordon J; Ruseckas, Arvydas; Samuel, Ifor D W

2010-09-02

Internal conversion (IC) between excited electronic states is a fundamental photophysical process that is important for understanding protection from UV radiation, energy transfer pathways and electron injection in artificial photosynthetic systems and organic solar cells. We have studied IC between three singlet MLCT states in an iridium complex using femtosecond fluorescence spectroscopy. Very fast IC with a time constant of <20 fs is observed from the highest state and a much slower relaxation to the lowest energy singlet state on a 70 fs time scale. The abrupt slowdown of the relaxation rate occurs when there is >0.6 eV of vibrational energy stored in the complex that has to be dissipated by intramolecular vibrational redistribution before further IC to the lower energy states can occur. These results show that the ability to dissipate vibrational energy can control the relaxation process in this class of materials.

Blue-Enriched Light Enhances Alertness but Impairs Accurate Performance in Evening Chronotypes Driving in the Morning.

PubMed

Rodríguez-Morilla, Beatriz; Madrid, Juan A; Molina, Enrique; Pérez-Navarro, José; Correa, Ángel

2018-01-01

Attention maintenance is highly demanding and typically leads to vigilance decrement along time on task. Therefore, performance in tasks involving vigilance maintenance for long periods, such as driving, tends to deteriorate over time. Cognitive performance has been demonstrated to fluctuate over 24 h of the day (known as circadian oscillations), thus showing peaks and troughs depending on the time of day (leading to optimal and suboptimal times of day, respectively). Consequently, vigilance decrements are more pronounced along time on task when it is performed at suboptimal times of day. According to research, light exposure (especially blue-enriched white) enhances alertness. Thus, it has been proposed to prevent the vigilance decrement under such adverse circumstances. We aimed to explore the effects of blue-enriched white light (vs. dim light) on the performance of a simulated driving task at a suboptimal time of day. A group of evening-types was tested at 8 am, as this chronotype had previously shown their largest vigilance decrement at that time. In the dim light condition, vigilance decrements were expected on both subjective (as increments in the Karolinska Sleepiness Scale scores) and behavioral measures [as slower reaction times (RTs) in the auditory Psychomotor Vigilance Task, slower RTs to unexpected events during driving, and deteriorated driving accuracy along time on task]. Physiological activation was expected to decrease (as indexed by an increase of the distal-proximal temperature gradient, DPG). Under blue-enriched white light, all these trends should be attenuated. Results from the control dim light condition replicated the vigilance decrement in all measures. Most important, the blue-enriched white light attenuated this decrement, leading to both lower DPG and faster RTs. However, it impaired accuracy of driving performance, and did not have any effect on subjective sleepiness. We conclude that exposure to blue-enriched light provides an effective countermeasure to enhance vigilance performance at suboptimal times of day, according to measures such as RTs. However, it should be considered that alerting effects of light could impair accuracy in precision tasks as keeping a proper car position. The current findings provide ergonomic implications for safety and fatigue related management systems.

Reduced dual-task gait speed is associated with visual Go/No-Go brain network activation in children and adolescents with concussion.

PubMed

Howell, David R; Meehan, William P; Barber Foss, Kim D; Reches, Amit; Weiss, Michal; Myer, Gregory D

2018-05-31

To investigate the association between dual-task gait performance and brain network activation (BNA) using an electroencephalography (EEG)-based Go/No-Go paradigm among children and adolescents with concussion. Participants with a concussion completed a visual Go/No-Go task with collection of electroencephalogram brain activity. Data were treated with BNA analysis, which involves an algorithmic approach to EEG-ERP activation quantification. Participants also completed a dual-task gait assessment. The relationship between dual-task gait speed and BNA was assessed using multiple linear regression models. Participants (n = 20, 13.9 ± 2.3 years of age, 50% female) were tested at a mean of 7.0 ± 2.5 days post-concussion and were symptomatic at the time of testing (post-concussion symptom scale = 40.4 ± 21.9). Slower dual-task average gait speed (mean = 82.2 ± 21.0 cm/s) was significantly associated with lower relative time BNA scores (mean = 39.6 ± 25.8) during the No-Go task (β = 0.599, 95% CI = 0.214, 0.985, p = 0.005, R 2  = 0.405), while controlling for the effect of age and gender. Among children and adolescents with a concussion, slower dual-task gait speed was independently associated with lower BNA relative time scores during a visual Go/No-Go task. The relationship between abnormal gait behaviour and brain activation deficits may be reflective of disruption to multiple functional abilities after concussion.

Slow cooling and highly efficient extraction of hot carriers in colloidal perovskite nanocrystals.

PubMed

Li, Mingjie; Bhaumik, Saikat; Goh, Teck Wee; Kumar, Muduli Subas; Yantara, Natalia; Grätzel, Michael; Mhaisalkar, Subodh; Mathews, Nripan; Sum, Tze Chien

2017-02-08

Hot-carrier solar cells can overcome the Schottky-Queisser limit by harvesting excess energy from hot carriers. Inorganic semiconductor nanocrystals are considered prime candidates. However, hot-carrier harvesting is compromised by competitive relaxation pathways (for example, intraband Auger process and defects) that overwhelm their phonon bottlenecks. Here we show colloidal halide perovskite nanocrystals transcend these limitations and exhibit around two orders slower hot-carrier cooling times and around four times larger hot-carrier temperatures than their bulk-film counterparts. Under low pump excitation, hot-carrier cooling mediated by a phonon bottleneck is surprisingly slower in smaller nanocrystals (contrasting with conventional nanocrystals). At high pump fluence, Auger heating dominates hot-carrier cooling, which is slower in larger nanocrystals (hitherto unobserved in conventional nanocrystals). Importantly, we demonstrate efficient room temperature hot-electrons extraction (up to ∼83%) by an energy-selective electron acceptor layer within 1 ps from surface-treated perovskite NCs thin films. These insights enable fresh approaches for extremely thin absorber and concentrator-type hot-carrier solar cells.

Large- to small-scale dynamo in domains of large aspect ratio: kinematic regime

NASA Astrophysics Data System (ADS)

Shumaylova, Valeria; Teed, Robert J.; Proctor, Michael R. E.

2017-04-01

The Sun's magnetic field exhibits coherence in space and time on much larger scales than the turbulent convection that ultimately powers the dynamo. In this work, we look for numerical evidence of a large-scale magnetic field as the magnetic Reynolds number, Rm, is increased. The investigation is based on the simulations of the induction equation in elongated periodic boxes. The imposed flows considered are the standard ABC flow (named after Arnold, Beltrami & Childress) with wavenumber ku = 1 (small-scale) and a modulated ABC flow with wavenumbers ku = m, 1, 1 ± m, where m is the wavenumber corresponding to the long-wavelength perturbation on the scale of the box. The critical magnetic Reynolds number R_m^{crit} decreases as the permitted scale separation in the system increases, such that R_m^{crit} ∝ [L_x/L_z]^{-1/2}. The results show that the α-effect derived from the mean-field theory ansatz is valid for a small range of Rm after which small scale dynamo instability occurs and the mean-field approximation is no longer valid. The transition from large- to small-scale dynamo is smooth and takes place in two stages: a fast transition into a predominantly small-scale magnetic energy state and a slower transition into even smaller scales. In the range of Rm considered, the most energetic Fourier component corresponding to the structure in the long x-direction has twice the length-scale of the forcing scale. The long-wavelength perturbation imposed on the ABC flow in the modulated case is not preserved in the eigenmodes of the magnetic field.

BAL QSOs AND EXTREME UFOs: THE EDDINGTON CONNECTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zubovas, Kastytis; King, Andrew, E-mail: kastytis.zubovas@ftmc.lt

We suggest a common physical origin connecting the fast, highly ionized winds (UFOs) seen in nearby active galactic nuclei (AGNs), and the slower and less ionized winds of broad absorption line (BAL) QSOs. The primary difference is the mass-loss rate in the wind, which is ultimately determined by the rate at which mass is fed toward the central supermassive black hole (SMBH) on large scales. This is below the Eddington accretion rate in most UFOs, and slightly super-Eddington in extreme UFOs such as PG1211+143, but ranges up to {approx}10-50 times this in BAL QSOs. For UFOs this implies black holemore » accretion rates and wind mass-loss rates which are at most comparable to Eddington, giving fast, highly ionized winds. In contrast, BAL QSO black holes have mildly super-Eddington accretion rates, and drive winds whose mass-loss rates are significantly super-Eddington, and so are slower and less ionized. This picture correctly predicts the velocities and ionization states of the observed winds, including the recently discovered one in SDSS J1106+1939. We suggest that luminous AGNs may evolve through a sequence from BAL QSO through LoBAL to UFO-producing Seyfert or quasar as their Eddington factors drop during the decay of a bright accretion event. LoBALs correspond to a short-lived stage in which the AGN radiation pressure largely evacuates the ionization cone, but before the large-scale accretion rate has dropped to the Eddington value. We show that sub-Eddington wind rates would produce an M-{sigma} relation lying above that observed. We conclude that significant SMBH mass growth must occur in super-Eddington phases, either as BAL QSOs, extreme UFOs, or obscured from direct observation.« less

BAL QSOs and Extreme UFOs: The Eddington Connection

NASA Astrophysics Data System (ADS)

Zubovas, Kastytis; King, Andrew

2013-05-01

We suggest a common physical origin connecting the fast, highly ionized winds (UFOs) seen in nearby active galactic nuclei (AGNs), and the slower and less ionized winds of broad absorption line (BAL) QSOs. The primary difference is the mass-loss rate in the wind, which is ultimately determined by the rate at which mass is fed toward the central supermassive black hole (SMBH) on large scales. This is below the Eddington accretion rate in most UFOs, and slightly super-Eddington in extreme UFOs such as PG1211+143, but ranges up to ~10-50 times this in BAL QSOs. For UFOs this implies black hole accretion rates and wind mass-loss rates which are at most comparable to Eddington, giving fast, highly ionized winds. In contrast, BAL QSO black holes have mildly super-Eddington accretion rates, and drive winds whose mass-loss rates are significantly super-Eddington, and so are slower and less ionized. This picture correctly predicts the velocities and ionization states of the observed winds, including the recently discovered one in SDSS J1106+1939. We suggest that luminous AGNs may evolve through a sequence from BAL QSO through LoBAL to UFO-producing Seyfert or quasar as their Eddington factors drop during the decay of a bright accretion event. LoBALs correspond to a short-lived stage in which the AGN radiation pressure largely evacuates the ionization cone, but before the large-scale accretion rate has dropped to the Eddington value. We show that sub-Eddington wind rates would produce an M-σ relation lying above that observed. We conclude that significant SMBH mass growth must occur in super-Eddington phases, either as BAL QSOs, extreme UFOs, or obscured from direct observation.

Simultaneous Observations of a Large-scale Wave Event in the Solar Atmosphere: From Photosphere to Corona

NASA Astrophysics Data System (ADS)

Shen, Yuandeng; Liu, Yu

2012-06-01

For the first time, we report a large-scale wave that was observed simultaneously in the photosphere, chromosphere, transition region, and low corona layers of the solar atmosphere. Using the high temporal and high spatial resolution observations taken by the Solar Magnetic Activity Research Telescope at Hida Observatory and the Atmospheric Imaging Assembly (AIA) on board Solar Dynamic Observatory, we find that the wave evolved synchronously at different heights of the solar atmosphere, and it propagated at a speed of 605 km s-1 and showed a significant deceleration (-424 m s-2) in the extreme-ultraviolet (EUV) observations. During the initial stage, the wave speed in the EUV observations was 1000 km s-1, similar to those measured from the AIA 1700 Å (967 km s-1) and 1600 Å (893 km s-1) observations. The wave was reflected by a remote region with open fields, and a slower wave-like feature at a speed of 220 km s-1 was also identified following the primary fast wave. In addition, a type-II radio burst was observed to be associated with the wave. We conclude that this wave should be a fast magnetosonic shock wave, which was first driven by the associated coronal mass ejection and then propagated freely in the corona. As the shock wave propagated, its legs swept the solar surface and thereby resulted in the wave signatures observed in the lower layers of the solar atmosphere. The slower wave-like structure following the primary wave was probably caused by the reconfiguration of the low coronal magnetic fields, as predicted in the field-line stretching model.

Magnetized cosmological perturbations in the post-recombination era

NASA Astrophysics Data System (ADS)

Vasileiou, Hera; Tsagas, Christos G.

2016-01-01

We study inhomogeneous magnetized cosmologies through the post-recombination era in the framework of Newtonian gravity and the ideal-magnetohydrodynamic limit. The non-linear kinematic and dynamic equations are derived and linearized around the Newtonian counterpart of the Einstein-de Sitter universe. This allows for a direct comparison with the earlier relativistic treatments of the issue. Focusing on the evolution of linear density perturbations, we provide new analytic solutions which include the effects of the magnetic pressure as well as those of the field's tension. We confirm that the pressure of field inhibits the growth of density distortions and can induce a purely magnetic Jeans length. On scales larger than the aforementioned characteristic length the inhomogeneities grow, though slower than in non-magnetized universes. Wavelengths smaller than the magnetic Jeans length typically oscillate with decreasing amplitude. We also identify a narrow range of scales, just below the Jeans length, where the perturbations exhibit a slower power-law decay. In all cases, the effect of the field is proportional to its strength and increases as we move to progressively smaller lengths.

Voluntary sway and rapid orthogonal transitions of voluntary sway in young adults, and low and high fall-risk older adults.

PubMed

Tucker, Murray G; Kavanagh, Justin J; Morrison, Steven; Barrett, Rod S

2009-10-01

Falls amongst older people have been linked to reduced postural stability and slowed movement responses. The objective of this study was to examine differences in postural stability and the speed of response between young adults, low fall-risk older adults, and high fall-risk older adults during voluntary postural sway movements. Twenty-five young adults (25+/-4 years), and 32 low fall-risk (74+/-5 years), and 16 high fall-risk (79+/-7 years) older adults performed voluntary sway and rapid orthogonal transitions of voluntary sway between the anterior-posterior and medial-lateral directions. Measures included reaction and movement time and the amplitudes of the centre of pressure, centre of mass, and the separation distance between the centre of pressure and centre of mass. Both fall-risk groups compared to the young had slower reaction and movement time, greater centre of pressure and/or centre of mass amplitude in the orthogonal (non-target) direction during voluntary sway, and reduced anterior-posterior and medial-lateral separation between the centre of pressure and centre of mass during voluntary sway and orthogonal transitions. High compared to low fall-risk individuals had slower reaction and movement time, increased non-target centre of mass amplitude during voluntary sway, and reduced medial-lateral centre of pressure and centre of mass separation during voluntary sway and orthogonal transitions. Age-related deterioration of postural control resulted in slower reactive responses and reduced control of the direction of body movement during voluntary sway and orthogonal transitions. Slower postural reaction and movement time and reduced medial-lateral control of the centre of mass during voluntary sway movements are associated with increased fall-risk in community-living older people.

Injury rates and injury risk factors among federal bureau of investigation new agent trainees

PubMed Central

2011-01-01

Background A one-year prospective examination of injury rates and injury risk factors was conducted in Federal Bureau of Investigation (FBI) new agent training. Methods Injury incidents were obtained from medical records and injury compensation forms. Potential injury risk factors were acquired from a lifestyle questionnaire and existing data at the FBI Academy. Results A total of 426 men and 105 women participated in the project. Thirty-five percent of men and 42% of women experienced one or more injuries during training. The injury incidence rate was 2.5 and 3.2 injuries/1,000 person-days for men and women, respectively (risk ratio (women/men) = 1.3, 95% confidence interval = 0.9-1.7). The activities most commonly associated with injuries (% of total) were defensive tactics training (58%), physical fitness training (20%), physical fitness testing (5%), and firearms training (3%). Among the men, higher injury risk was associated with older age, slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the physical fitness test (PFT), lower self-rated physical activity, lower frequency of aerobic exercise, a prior upper or lower limb injury, and prior foot or knee pain that limited activity. Among the women higher injury risk was associated with slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the PFT, and prior back pain that limited activity. Conclusion The results of this investigation supported those of a previous retrospective investigation emphasizing that lower fitness and self-reported pain limiting activity were associated with higher injury risk among FBI new agents. PMID:22166096

ITG-TEM turbulence simulation with bounce-averaged kinetic electrons in tokamak geometry

NASA Astrophysics Data System (ADS)

Kwon, Jae-Min; Qi, Lei; Yi, S.; Hahm, T. S.

2017-06-01

We develop a novel numerical scheme to simulate electrostatic turbulence with kinetic electron responses in magnetically confined toroidal plasmas. Focusing on ion gyro-radius scale turbulences with slower frequencies than the time scales for electron parallel motions, we employ and adapt the bounce-averaged kinetic equation to model trapped electrons for nonlinear turbulence simulation with Coulomb collisions. Ions are modeled by employing the gyrokinetic equation. The newly developed scheme is implemented on a global δf particle in cell code gKPSP. By performing linear and nonlinear simulations, it is demonstrated that the new scheme can reproduce key physical properties of Ion Temperature Gradient (ITG) and Trapped Electron Mode (TEM) instabilities, and resulting turbulent transport. The overall computational cost of kinetic electrons using this novel scheme is limited to 200%-300% of the cost for simulations with adiabatic electrons. Therefore the new scheme allows us to perform kinetic simulations with trapped electrons very efficiently in magnetized plasmas.

Are there ergodic limits to evolution? Ergodic exploration of genome space and convergence

PubMed Central

McLeish, Tom C. B.

2015-01-01

We examine the analogy between evolutionary dynamics and statistical mechanics to include the fundamental question of ergodicity—the representative exploration of the space of possible states (in the case of evolution this is genome space). Several properties of evolutionary dynamics are identified that allow a generalization of the ergodic dynamics, familiar in dynamical systems theory, to evolution. Two classes of evolved biological structure then arise, differentiated by the qualitative duration of their evolutionary time scales. The first class has an ergodicity time scale (the time required for representative genome exploration) longer than available evolutionary time, and has incompletely explored the genotypic and phenotypic space of its possibilities. This case generates no expectation of convergence to an optimal phenotype or possibility of its prediction. The second, more interesting, class exhibits an evolutionary form of ergodicity—essentially all of the structural space within the constraints of slower evolutionary variables have been sampled; the ergodicity time scale for the system evolution is less than the evolutionary time. In this case, some convergence towards similar optima may be expected for equivalent systems in different species where both possess ergodic evolutionary dynamics. When the fitness maximum is set by physical, rather than co-evolved, constraints, it is additionally possible to make predictions of some properties of the evolved structures and systems. We propose four structures that emerge from evolution within genotypes whose fitness is induced from their phenotypes. Together, these result in an exponential speeding up of evolution, when compared with complete exploration of genomic space. We illustrate a possible case of application and a prediction of convergence together with attaining a physical fitness optimum in the case of invertebrate compound eye resolution. PMID:26640648

Are there ergodic limits to evolution? Ergodic exploration of genome space and convergence.

PubMed

McLeish, Tom C B

2015-12-06

We examine the analogy between evolutionary dynamics and statistical mechanics to include the fundamental question of ergodicity-the representative exploration of the space of possible states (in the case of evolution this is genome space). Several properties of evolutionary dynamics are identified that allow a generalization of the ergodic dynamics, familiar in dynamical systems theory, to evolution. Two classes of evolved biological structure then arise, differentiated by the qualitative duration of their evolutionary time scales. The first class has an ergodicity time scale (the time required for representative genome exploration) longer than available evolutionary time, and has incompletely explored the genotypic and phenotypic space of its possibilities. This case generates no expectation of convergence to an optimal phenotype or possibility of its prediction. The second, more interesting, class exhibits an evolutionary form of ergodicity-essentially all of the structural space within the constraints of slower evolutionary variables have been sampled; the ergodicity time scale for the system evolution is less than the evolutionary time. In this case, some convergence towards similar optima may be expected for equivalent systems in different species where both possess ergodic evolutionary dynamics. When the fitness maximum is set by physical, rather than co-evolved, constraints, it is additionally possible to make predictions of some properties of the evolved structures and systems. We propose four structures that emerge from evolution within genotypes whose fitness is induced from their phenotypes. Together, these result in an exponential speeding up of evolution, when compared with complete exploration of genomic space. We illustrate a possible case of application and a prediction of convergence together with attaining a physical fitness optimum in the case of invertebrate compound eye resolution.

Insights into Evaporative Droplet Dynamics in the High-Wind Atmospheric Boundary Layer

NASA Astrophysics Data System (ADS)

Peng, T.; Richter, D. H.

2017-12-01

Sea-spray droplets ejected into the air-sea boundary layer take part in a series of complex transport processes. To model the air-sea exchange of heat and moisture under high-wind conditions, it is important yet challenging to understand influences of evaporative droplets in the atmospheric boundary layer. We implement a high-resolution Eulerian-Lagrangian algorithm with droplets laden in a turbulent open-channel flow to reveal the dynamic and thermodynamic characteristics of evaporating sea spray. Our past numerical simulations demonstrated an overall weak modification to the total heat flux by evaporative droplets. This is due to redistributed sensible and latent heat fluxes from relatively small droplets that respond rapidly to the ambient environment or the limited residence time of larger droplets. However, droplets with a slower thermodynamic response to the environment indicate a potential to enhance the total heat flux, but this is dependent on concentration and suspension time. In the current study, we focus on correlations between the residence time and thermodynamic statistics of droplets in order to better understand how best to parameterize in large-scale models. In addition, we focus in detail on the different scales of turbulence to further characterize the range of influence that evaporating droplets have on the surrounding fluid.

Time-Ordered Networks Reveal Limitations to Information Flow in Ant Colonies

PubMed Central

Blonder, Benjamin; Dornhaus, Anna

2011-01-01

Background An important function of many complex networks is to inhibit or promote the transmission of disease, resources, or information between individuals. However, little is known about how the temporal dynamics of individual-level interactions affect these networks and constrain their function. Ant colonies are a model comparative system for understanding general principles linking individual-level interactions to network-level functions because interactions among individuals enable integration of multiple sources of information to collectively make decisions, and allocate tasks and resources. Methodology/Findings Here we show how the temporal and spatial dynamics of such individual interactions provide upper bounds to rates of colony-level information flow in the ant Temnothorax rugatulus. We develop a general framework for analyzing dynamic networks and a mathematical model that predicts how information flow scales with individual mobility and group size. Conclusions/Significance Using thousands of time-stamped interactions between uniquely marked ants in four colonies of a range of sizes, we demonstrate that observed maximum rates of information flow are always slower than predicted, and are constrained by regulation of individual mobility and contact rate. By accounting for the ordering and timing of interactions, we can resolve important difficulties with network sampling frequency and duration, enabling a broader understanding of interaction network functioning across systems and scales. PMID:21625450

The Nazca-South American convergence rate and the recurrence of the great 1960 Chilean earthquake

NASA Technical Reports Server (NTRS)

Stein, S.; Engeln, J. F.; Demets, C.; Gordon, R. G.; Woods, D.

1986-01-01

The seismic slip rate along the Chile Trench estimated from the slip in the great 1960 earthquake and the recurrence history of major earthquakes has been interpreted as consistent with the subduction rate of the Nazca plate beneath South America. The convergence rate, estimated from global relative plate motion models, depends significantly on closure of the Nazca - Antarctica - South America circuit. NUVEL-1, a new plate motion model which incorporates recently determined spreading rates on the Chile Rise, shows that the average convergence rate over the last three million years is slower than previously estimated. If this time-averaged convergence rate provides an appropriate upper bound for the seismic slip rate, either the characteristic Chilean subduction earthquake is smaller than the 1960 event, the average recurrence interval is greater than observed in the last 400 years, or both. These observations bear out the nonuniformity of plate motions on various time scales, the variability in characteristic subduction zone earthquake size, and the limitations of recurrence time estimates.

Non-equilibrium reactive flux: A unified framework for slow and fast reaction kinetics.

PubMed

Bose, Amartya; Makri, Nancy

2017-10-21

The flux formulation of reaction rate theory is recast in terms of the expectation value of the reactive flux with an initial condition that corresponds to a non-equilibrium, factorized reactant density. In the common case of slow reactive processes, the non-equilibrium expression reaches the plateau regime only slightly slower than the equilibrium flux form. When the reactants are described by a single quantum state, as in the case of electron transfer reactions, the factorized reactant density describes the true initial condition of the reactive process. In such cases, the time integral of the non-equilibrium flux expression yields the reactant population as a function of time, allowing characterization of the dynamics in cases where there is no clear separation of time scales and thus a plateau regime cannot be identified. The non-equilibrium flux offers a unified approach to the kinetics of slow and fast chemical reactions and is ideally suited to mixed quantum-classical methods.

Seasonal stratospheric photochemistry on Uranus and Neptune

NASA Astrophysics Data System (ADS)

Moses, Julianne I.; Fletcher, Leigh N.; Greathouse, Thomas K.; Orton, Glenn S.; Hue, Vincent

2018-06-01

A time-variable 1D photochemical model is used to study the distribution of stratospheric hydrocarbons as a function of altitude, latitude, and season on Uranus and Neptune. The results for Neptune indicate that in the absence of stratospheric circulation or other meridional transport processes, the hydrocarbon abundances exhibit strong seasonal and meridional variations in the upper stratosphere, but that these variations become increasingly damped with depth due to increasing dynamical and chemical time scales. At high altitudes, hydrocarbon mixing ratios are typically largest where the solar insolation is the greatest, leading to strong hemispheric dichotomies between the summer-to-fall hemisphere and winter-to-spring hemisphere. At mbar pressures and deeper, slower chemistry and diffusion lead to latitude variations that become more symmetric about the equator. On Uranus, the stagnant, poorly mixed stratosphere confines methane and its photochemical products to higher pressures, where chemistry and diffusion time scales remain large. Seasonal variations in hydrocarbons are therefore predicted to be more muted on Uranus, despite the planet's very large obliquity. Radiative-transfer simulations demonstrate that latitude variations in hydrocarbons on both planets are potentially observable with future JWST mid-infrared spectral imaging. Our seasonal model predictions for Neptune compare well with retrieved C2H2 and C2H6 abundances from spatially resolved ground-based observations (no such observations currently exist for Uranus), suggesting that stratospheric circulation - which was not included in these models - may have little influence on the large-scale meridional hydrocarbon distributions on Neptune, unlike the situation on Jupiter and Saturn.

Ethical sensitivity in obsessive-compulsive disorder and generalized anxiety disorder: the role of reversal learning.

PubMed

Szabó, Csilla; Németh, Attila; Kéri, Szabolcs

2013-12-01

In obsessive-compulsive disorder (OCD), amplified moral sensitivity may be related to the orbitofrontal-striatal circuit, which is also critical in reversal learning. This study examined three questions: (1) What aspects of ethical sensitivity is altered in OCD?; (2) What is the relationship between ethical sensitivity and reversal learning?; (3) Are potential alterations in ethical sensitivity and reversal learning present in generalized anxiety disorder (GAD)? Participants were 28 outpatients with OCD, 21 individuals with GAD, and 30 matched healthy controls. Participants received the ethical sensitivity scale questionnaire (ESSQ), rating scales for clinical symptoms, a reversal learning task, and the Wisconsin Card Sorting Test (WCST). We found higher ethical sensitivity scores in OCD compared with healthy controls in the case of generating interpretations and options and identifying the consequences of actions. Individuals with OCD displayed prolonged reaction times on probabilistic errors without shift and final reversal errors. Participants with GAD did not differ from healthy controls on the ESSQ, but they were slower on reversal learning relative to nonpatients. In OCD, reaction time on final reversal errors mediated the relationship between ethical sensitivity and compulsions. WCST performance was intact in OCD and GAD. Small sample size, limited neuropsychological assessment, self-rating scale for ethical sensitivity. Prolonged reaction time at switching reinforcement contingencies is related to increased ethical sensitivity in OCD. Slow affective switching may link ethical sensitivity and compulsions. Copyright © 2013 Elsevier Ltd. All rights reserved.

Modeling Photochemical Dynamics in Optically Active Energetic Materials

NASA Astrophysics Data System (ADS)

Nelson, Tammie; Bjorgaard, Josiah; Greenfield, Margo; Bolme, Cindy; Brown, Katie; McGrane, Shawn; Scharff, R. Jason; Tretiak, Sergei

Most high explosives (HEs) absorb in the UV range, making it difficult to develop HEs that can be excited with standard lasers. The conventional optical initiation mechanisms require high laser intensity and occur via indirect thermal or shock processes. A photochemical initiation mechanism could allow control over the chemistry contributing to decomposition leading to initiation. We combine UV femtosecond transient absorption (TA) spectroscopy and excited state femtosecond stimulated Raman spectroscopy (FSRS) with Nonadiabatic Excited State Molecular Dynamics (NA-ESMD) to model the photochemical pathways in nitromethane (NM), a low sensitivity HE known to undergo UV photolysis. We investigate the ultrafast photodecomposition of NM from the nπ* state excited at 266 nm. The FSRS photoproduct spectrum points to methyl nitrite formation as the dominant photoproduct. A total photolysis quantum yield of 0.27 and an nπ* state lifetime of 20 fs were predicted from simulations. Predicted time scales reveal that NO2 dissociation occurs in 81 +/-4 fs and methyl nitrite formation is much slower at 452 +/-9 fs corresponding to the absorption feature in the TA spectrum. The relative time scales are consistent with isomerization by NO2 dissociation and ONO rebinding.

ABC of multi-fractal spacetimes and fractional sea turtles

NASA Astrophysics Data System (ADS)

Calcagni, Gianluca

2016-04-01

We clarify what it means to have a spacetime fractal geometry in quantum gravity and show that its properties differ from those of usual fractals. A weak and a strong definition of multi-scale and multi-fractal spacetimes are given together with a sketch of the landscape of multi-scale theories of gravitation. Then, in the context of the fractional theory with q-derivatives, we explore the consequences of living in a multi-fractal spacetime. To illustrate the behavior of a non-relativistic body, we take the entertaining example of a sea turtle. We show that, when only the time direction is fractal, sea turtles swim at a faster speed than in an ordinary world, while they swim at a slower speed if only the spatial directions are fractal. The latter type of geometry is the one most commonly found in quantum gravity. For time-like fractals, relativistic objects can exceed the speed of light, but strongly so only if their size is smaller than the range of particle-physics interactions. We also find new results about log-oscillating measures, the measure presentation and their role in physical observations and in future extensions to nowhere-differentiable stochastic spacetimes.

Clogging transition of many-particle systems flowing through bottlenecks

NASA Astrophysics Data System (ADS)

Zuriguel, Iker; Parisi, Daniel Ricardo; Hidalgo, Raúl Cruz; Lozano, Celia; Janda, Alvaro; Gago, Paula Alejandra; Peralta, Juan Pablo; Ferrer, Luis Miguel; Pugnaloni, Luis Ariel; Clément, Eric; Maza, Diego; Pagonabarraga, Ignacio; Garcimartín, Angel

2014-12-01

When a large set of discrete bodies passes through a bottleneck, the flow may become intermittent due to the development of clogs that obstruct the constriction. Clogging is observed, for instance, in colloidal suspensions, granular materials and crowd swarming, where consequences may be dramatic. Despite its ubiquity, a general framework embracing research in such a wide variety of scenarios is still lacking. We show that in systems of very different nature and scale -including sheep herds, pedestrian crowds, assemblies of grains, and colloids- the probability distribution of time lapses between the passages of consecutive bodies exhibits a power-law tail with an exponent that depends on the system condition. Consequently, we identify the transition to clogging in terms of the divergence of the average time lapse. Such a unified description allows us to put forward a qualitative clogging state diagram whose most conspicuous feature is the presence of a length scale qualitatively related to the presence of a finite size orifice. This approach helps to understand paradoxical phenomena, such as the faster-is-slower effect predicted for pedestrians evacuating a room and might become a starting point for researchers working in a wide variety of situations where clogging represents a hindrance.

Quantum Hooke's Law to Classify Pulse Laser Induced Ultrafast Melting

NASA Astrophysics Data System (ADS)

Hu, Hao; Ding, Hepeng; Liu, Feng

2014-03-01

We investigate the ultrafast crystal-to-amorphous phase transition induced by femtosecond pulse laser excitation by exploiting the property of quantum electronic stress (QES) induced by the electron-hole plasma, which follows quantum Hooke's law. We demonstrates that two types of crystal-to-amorphous transitions occur in two distinct material classes: the faster nonthermal process, having a time scale shorter than one picosecond (ps), must occur in materials like ice having an anomalous phase diagram characterized with dTm/dP <0, where Tm is the melting temperature and P is pressure; while the slower thermal process, having a time scale of several ps, occurs preferably in other materials. The nonthermal process is driven by the QES acting like a negative internal pressure, which is generated predominantly by the holes in the electron-hole plasma that increases linearly with hole density. These findings significantly advance our fundamental understanding of physics underlying the ultrafast crystal-to-amorphous phase transitions, enabling quantitative a priori prediction. The work was supported by DOE-BES (Grant # DE-FG02-04ER46148), NSF MRSEC (Grant No. DMR-1121252) and DOE EFRC (Grant Number DE-SC0001061).

Clogging transition of many-particle systems flowing through bottlenecks

PubMed Central

Zuriguel, Iker; Parisi, Daniel Ricardo; Hidalgo, Raúl Cruz; Lozano, Celia; Janda, Alvaro; Gago, Paula Alejandra; Peralta, Juan Pablo; Ferrer, Luis Miguel; Pugnaloni, Luis Ariel; Clément, Eric; Maza, Diego; Pagonabarraga, Ignacio; Garcimartín, Angel

2014-01-01

When a large set of discrete bodies passes through a bottleneck, the flow may become intermittent due to the development of clogs that obstruct the constriction. Clogging is observed, for instance, in colloidal suspensions, granular materials and crowd swarming, where consequences may be dramatic. Despite its ubiquity, a general framework embracing research in such a wide variety of scenarios is still lacking. We show that in systems of very different nature and scale -including sheep herds, pedestrian crowds, assemblies of grains, and colloids- the probability distribution of time lapses between the passages of consecutive bodies exhibits a power-law tail with an exponent that depends on the system condition. Consequently, we identify the transition to clogging in terms of the divergence of the average time lapse. Such a unified description allows us to put forward a qualitative clogging state diagram whose most conspicuous feature is the presence of a length scale qualitatively related to the presence of a finite size orifice. This approach helps to understand paradoxical phenomena, such as the faster-is-slower effect predicted for pedestrians evacuating a room and might become a starting point for researchers working in a wide variety of situations where clogging represents a hindrance. PMID:25471601

Clogging transition of many-particle systems flowing through bottlenecks.

PubMed

Zuriguel, Iker; Parisi, Daniel Ricardo; Hidalgo, Raúl Cruz; Lozano, Celia; Janda, Alvaro; Gago, Paula Alejandra; Peralta, Juan Pablo; Ferrer, Luis Miguel; Pugnaloni, Luis Ariel; Clément, Eric; Maza, Diego; Pagonabarraga, Ignacio; Garcimartín, Angel

2014-12-04

When a large set of discrete bodies passes through a bottleneck, the flow may become intermittent due to the development of clogs that obstruct the constriction. Clogging is observed, for instance, in colloidal suspensions, granular materials and crowd swarming, where consequences may be dramatic. Despite its ubiquity, a general framework embracing research in such a wide variety of scenarios is still lacking. We show that in systems of very different nature and scale -including sheep herds, pedestrian crowds, assemblies of grains, and colloids- the probability distribution of time lapses between the passages of consecutive bodies exhibits a power-law tail with an exponent that depends on the system condition. Consequently, we identify the transition to clogging in terms of the divergence of the average time lapse. Such a unified description allows us to put forward a qualitative clogging state diagram whose most conspicuous feature is the presence of a length scale qualitatively related to the presence of a finite size orifice. This approach helps to understand paradoxical phenomena, such as the faster-is-slower effect predicted for pedestrians evacuating a room and might become a starting point for researchers working in a wide variety of situations where clogging represents a hindrance.

Discrete event performance prediction of speculatively parallel temperature-accelerated dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zamora, Richard James; Voter, Arthur F.; Perez, Danny

Due to its unrivaled ability to predict the dynamical evolution of interacting atoms, molecular dynamics (MD) is a widely used computational method in theoretical chemistry, physics, biology, and engineering. Despite its success, MD is only capable of modeling time scales within several orders of magnitude of thermal vibrations, leaving out many important phenomena that occur at slower rates. The Temperature Accelerated Dynamics (TAD) method overcomes this limitation by thermally accelerating the state-to-state evolution captured by MD. Due to the algorithmically complex nature of the serial TAD procedure, implementations have yet to improve performance by parallelizing the concurrent exploration of multiplemore » states. Here we utilize a discrete event-based application simulator to introduce and explore a new Speculatively Parallel TAD (SpecTAD) method. We investigate the SpecTAD algorithm, without a full-scale implementation, by constructing an application simulator proxy (SpecTADSim). Finally, following this method, we discover that a nontrivial relationship exists between the optimal SpecTAD parameter set and the number of CPU cores available at run-time. Furthermore, we find that a majority of the available SpecTAD boost can be achieved within an existing TAD application using relatively simple algorithm modifications.« less

Discrete event performance prediction of speculatively parallel temperature-accelerated dynamics

DOE PAGES

Zamora, Richard James; Voter, Arthur F.; Perez, Danny; ...

2016-12-01

Due to its unrivaled ability to predict the dynamical evolution of interacting atoms, molecular dynamics (MD) is a widely used computational method in theoretical chemistry, physics, biology, and engineering. Despite its success, MD is only capable of modeling time scales within several orders of magnitude of thermal vibrations, leaving out many important phenomena that occur at slower rates. The Temperature Accelerated Dynamics (TAD) method overcomes this limitation by thermally accelerating the state-to-state evolution captured by MD. Due to the algorithmically complex nature of the serial TAD procedure, implementations have yet to improve performance by parallelizing the concurrent exploration of multiplemore » states. Here we utilize a discrete event-based application simulator to introduce and explore a new Speculatively Parallel TAD (SpecTAD) method. We investigate the SpecTAD algorithm, without a full-scale implementation, by constructing an application simulator proxy (SpecTADSim). Finally, following this method, we discover that a nontrivial relationship exists between the optimal SpecTAD parameter set and the number of CPU cores available at run-time. Furthermore, we find that a majority of the available SpecTAD boost can be achieved within an existing TAD application using relatively simple algorithm modifications.« less

Ten-year optical monitoring of PKS 0735+178: historical comparison, multiband behavior, and variability timescales

NASA Astrophysics Data System (ADS)

Ciprini, S.; Takalo, L. O.; Tosti, G.; Raiteri, C. M.; Fiorucci, M.; Villata, M.; Nucciarelli, G.; Lanteri, L.; Nilsson, K.; Ros, J. A.

2007-05-01

Aims:New data and results on the optical behavior of the prominent blazar PKS 0735+178 (also known as OI 158, S3 0735+17, DA 237, 1ES 0735+178, 3EG J0737+1721) are presented, through the most continuous BVRI data available in the period 1994-2004 (about 500 nights of observations). In addition, the whole historical light curve, and a new photometric calibration of comparison stars in the field of this source are reported. Methods: Several methods for time series analysis of sparse data sets are developed, adapted, and applied to the reconstructed historical light curve and to each observing season of our unpublished optical database on PKS 0735+178. Optical spectral indexes are calculated from the multi-band observations and studied on long-term (years) durations as well. For the first time in this source, variability modes, characteristic timescales, and the signal power spectrum are explored and identified over 3 decades in time with sufficient statistics. The novel investigation of mid-term optical scales (days, weeks), could be also applied and compared to blazar gamma-ray light curves that will be provided, on the same timescales, by the forthcoming GLAST observatory. Results: In the last 10 years the optical emission of PKS 0735+178 exhibited a rather achromatic behavior and a variability mode resembling the shot-noise. The source was at an intermediate or low brightness level, showing a mild flaring activity and a superimposition/succession of rapid and slower flares, without extraordinary and isolated outbursts, but, at any rate, characterized by one major active phase in 2001. Several mid-term scales of variability were found, the more common falling into duration intervals of about 27-28 days, 50-56 days and 76-79 days. Rapid variability in the historical light curve appears to be modulated by a general, slower, and rather oscillating temporal trend, where typical amplitudes of about 4.5, 8.5, and 11-13 years can be identified. This spectral and temporal analysis, accompanying our data publication, suggests the occurrence of distinctive signatures at mid-term durations that can likely be of transitory nature. On the other hand the possible pseudo-cyclical or multi-component modulations at long times could be more stable, recurrent and correlated to the bimodal radio flux behavior and the twisted radio structure observed over several years in this blazar.

Esophageal function testing using multichannel intraluminal impedance.

PubMed

Srinivasan, R; Vela, M F; Katz, P O; Tutuian, R; Castell, J A; Castell, D O

2001-03-01

Multichannel intraluminal impedance (MII) is a new technique for evaluation of bolus transport. We evaluated esophageal function using bolus transport time (BTT) and contraction wave velocity (CWV) of liquid, semisolid, and solid boluses. Ten healthy subjects underwent MII swallow evaluation with various boluses of sterile water (pH 5), applesauce, three different sized marshmallows, and iced and 130 degrees F water. The effect of bethanechol was also studied. There was no difference in BTT or CWV for all water volumes from 1 to 20 ml. There was significant linear increase of BTT with progressively larger volumes of applesauce, and BTT of applesauce was longer than for water. BTT was significantly longer with large marshmallows vs. small and medium and was longer than for water. BTT for iced water was similar to 130 degrees F water. Applesauce showed a significant linear decrease of CWV with progressively larger volumes and was slower than water. Marshmallow showed significantly slower CWV with the large vs. small, and CWV for ice water was significantly slower than 130 degrees F water. Therefore, BTT of liquid is constant, whereas BTT of semisolid and solid are volume dependent and longer than liquids. CWV of semisolids and solids are slower than liquids. CWV of cold liquids is slower than warm liquids. MII can be used as a discriminating test of esophageal function.

Useful field of view in simulated driving: Reaction times and eye movements of drivers

PubMed Central

Seya, Yasuhiro; Nakayasu, Hidetoshi; Yagi, Tadasu

2013-01-01

To examine the spatial distribution of a useful field of view (UFOV) in driving, reaction times (RTs) and eye movements were measured in simulated driving. In the experiment, a normal or mirror-reversed letter “E” was presented on driving images with different eccentricities and directions from the current gaze position. The results showed significantly slower RTs in the upper and upper left directions than in the other directions. The RTs were significantly slower in the left directions than in the right directions. These results suggest that the UFOV in driving may be asymmetrical among the meridians in the visual field. PMID:24349688

A VLA (Very Large Array) Search for 5 GHz Radio Transients and Variables at Low Galactic Latitudes

NASA Technical Reports Server (NTRS)

Ofek, E. O.; Frail, D. A.; Breslauer, B.; Kulkarni, S. R.; Chandra, P.; Gal-Yam, A.; Kasliwal, M. M.; Gehrels, N.

2012-01-01

We present the results of a 5GHz survey with the Very Large Array (VLA) and the expanded VLA, designed to search for short-lived (approx < 1 day) transients and to characterize the variability of radio sources at milli-Jansky levels. A total sky area of 2.66 sq. deg, spread over 141 fields at low Galactic latitudes (b approx equals 6 - 8 deg) was observed 16 times with a cadence that was chosen to sample timescales of days, months and years. Most of the data were reduced, analyzed and searched for transients in near real time. Interesting candidates were followed up using visible light telescopes (typical delays of 1 - 2 hr) and the X-Ray Telescope on board the Swift satellite. The final processing of the data revealed a single possible transient with a flux density of f(sub v) approx equals 2.4mJy. This implies a transients sky surface density of kappa(f(sub v) > 1.8mJy) = 0.039(exp +0.13,+0.18) (sub .0.032,.0.038) / sq. deg (1, 2 sigma confidence errors). This areal density is consistent with the sky surface density of transients from the Bower et al. survey extrapolated to 1.8mJy. Our observed transient areal density is consistent with a Neutron Stars (NSs) origin for these events. Furthermore, we use the data to measure the sources variability on days to years time scales, and we present the variability structure function of 5GHz sources. The mean structure function shows a fast increase on approximately 1 day time scale, followed by a slower increase on time scales of up to 10 days. On time scales between 10 - 60 days the structure function is roughly constant. We find that approx > 30% of the unresolved sources brighter than 1.8mJy are variable at the > 4-sigma confidence level, presumably due mainly to refractive scintillation.

Long time scale hard X-ray variability in Seyfert 1 galaxies

NASA Astrophysics Data System (ADS)

Markowitz, Alex Gary

This dissertation examines the relationship between long-term X-ray variability characteristics, black hole mass, and luminosity of Seyfert 1 Active Galactic Nuclei. High dynamic range power spectral density functions (PSDs) have been constructed for six Seyfert 1 galaxies. These PSDs show "breaks" or characteristic time scales, typically on the order of a few days. There is resemblance to PSDs of lower-mass Galactic X-ray binaries (XRBs), with the ratios of putative black hole masses and variability time scales approximately the same (106--7) between the two classes of objects. The data are consistent with a linear correlation between Seyfert PSD break time scale and black hole mass estimate; the relation extrapolates reasonably well over 6--7 orders of magnitude to XRBs. All of this strengthens the case for a physical similarity between Seyfert galaxies and XRBs. The first six years of RXTE monitoring of Seyfert 1s have been systematically analyzed to probe hard X-ray variability on multiple time scales in a total of 19 Seyfert is in an expansion of the survey of Markowitz & Edelson (2001). Correlations between variability amplitude, luminosity, and black hole mass are explored, the data support the model of PSD movement with black hole mass suggested by the PSD survey. All of the continuum variability results are consistent with relatively more massive black holes hosting larger X-ray emission regions, resulting in 'slower' observed variability. Nearly all sources in the sample exhibit stronger variability towards softer energies, consistent with softening as they brighten. Direct time-resolved spectral fitting has been performed on continuous RXTE monitoring of seven Seyfert is to study long-term spectral variability and Fe Kalpha variability characteristics. The Fe Kalpha line displays a wide range of behavior but varies less strongly than the broadband continuum. Overall, however, there is no strong evidence for correlated variability between the line and continuum, severely challenging models in which the line tracks continuum variations modified only by a light-travel time delay. This experiment yields further support for spectral softening as continuum flux increases.

The instantaneous radial growth rate of stellar discs

NASA Astrophysics Data System (ADS)

Pezzulli, G.; Fraternali, F.; Boissier, S.; Muñoz-Mateos, J. C.

2015-08-01

We present a new and simple method to measure the instantaneous mass and radial growth rates of the stellar discs of spiral galaxies, based on their star formation rate surface density (SFRD) profiles. Under the hypothesis that discs are exponential with time-varying scalelengths, we derive a universal theoretical profile for the SFRD, with a linear dependence on two parameters: the specific mass growth rate ν _ M ≡ dot{M}_⋆ /M_⋆ and the specific radial growth rate ν _ R ≡ dot{R}_⋆ /R_⋆ of the disc. We test our theory on a sample of 35 nearby spiral galaxies, for which we derive a measurement of νM and νR. 32/35 galaxies show the signature of ongoing inside-out growth (νR > 0). The typical derived e-folding time-scales for mass and radial growth in our sample are ˜10 and ˜30 Gyr, respectively, with some systematic uncertainties. More massive discs have a larger scatter in νM and νR, biased towards a slower growth, both in mass and size. We find a linear relation between the two growth rates, indicating that our galaxy discs grow in size at ˜0.35 times the rate at which they grow in mass; this ratio is largely unaffected by systematics. Our results are in very good agreement with theoretical expectations if known scaling relations of disc galaxies are not evolving with time.

Interaction of thermal and mechanical processes in steep permafrost rock walls: A conceptual approach

NASA Astrophysics Data System (ADS)

Draebing, D.; Krautblatter, M.; Dikau, R.

2014-12-01

Degradation of permafrost rock wall decreases stability and can initiate rock slope instability of all magnitudes. Rock instability is controlled by the balance of shear forces and shear resistances. The sensitivity of slope stability to warming results from a complex interplay of shear forces and resistances. Conductive, convective and advective heat transport processes act to warm, degrade and thaw permafrost in rock walls. On a seasonal scale, snow cover changes are a poorly understood key control of the timing and extent of thawing and permafrost degradation. We identified two potential critical time windows where shear forces might exceed shear resistances of the rock. In early summer combined hydrostatic and cryostatic pressure can cause a peak in shear force exceeding high frozen shear resistance and in autumn fast increasing shear forces can exceed slower increasing shear resistance. On a multiannual system scale, shear resistances change from predominantly rock-mechanically to ice-mechanically controlled. Progressive rock bridge failure results in an increase of sensitivity to warming. Climate change alters snow cover and duration and, hereby, thermal and mechanical processes in the rock wall. Amplified thawing of permafrost will result in higher rock slope instability and rock fall activity. We present a holistic conceptual approach connecting thermal and mechanical processes, validate parts of the model with geophysical and kinematic data and develop future scenarios to enhance understanding on system scale.

Transition from Sensorimotor Stage 5 to Stage 6 by Down Syndrome Children: A Response to Gibson.

ERIC Educational Resources Information Center

Mervis, Carolyn B.; Cardoso-Martins, Claudia

1984-01-01

The study compared longitudinally performance of six Down syndrome and six nonretarded children on Object Permanence and Means-Ends Relations Scales. Results indicated that Down syndrome children progressed from Sensorimotor Stage 5 to Stage 6 at the same rate as nonretarded children, once Down's Ss slower developmental pace was considered.…

Risk factors for injuries in the U.S. Army Ordnance School.

PubMed

Grier, Tyson L; Morrison, Stephanie; Knapik, Joseph J; Canham-Chervak, Michelle; Jones, Bruce H

2011-11-01

To investigate risk factors for time-loss injuries among soldiers attending U.S. Army Ordnance School Advanced Individual Training. Injuries were obtained from an injury surveillance system. A health questionnaire provided data on age, race, rank, current self-reported injury and illness, and tobacco use. Fitness data was obtained from operations office. Cumulative time-loss injury incidence was 31% for men and 54% for women. For men, higher risk of injury was associated with race, a current self-reported injury, smoking before entering the Army, lower sit-up performance, and slower 2-mile run times. For women, higher risk of injury was associated with race, a current self-reported injury, and slower 2-mile run times. Smoking cessation and fitness training before entry are potential strategies to reduce injuries among soldiers in the Ordnance School.

Beta-2- Adrenergic Receptor Genotype and Other Variables that Contribute to Labor Pain and Progress

PubMed Central

Reitman, Elena; Conell-Price, Jessamyn; Evansmilth, Jennifer; Olson, Luke; Drosinos, Sofia; Jasper, Nancy; Randolph, Paula; Smiley, Richard; Shafer, Steven; Flood, Pamela

2011-01-01

Background Beta-2-adrenergic receptor (β2AR) activity influences labor and its genotype affects the incidence of preterm delivery. We determined the effect of β2AR genotype on term labor progress and pain. Methods We prospectively enrolled 150 nulliparous parturients in the third trimester and obtained sensory thresholds, demographic information and DNA. Cervical dilation, pain scores and labor management data were extracted with associated times. The association of genetic and demographic factors with labor was tested with mixed effects models. Results Parturients who express Gln at the 27 position of the β2AR had slower labor (P<0.03). They progressedfrom 1–10cm dilation in approximately 21 hours compared to 14 hours in otherpatients. Asian ethnicity, previously associated with slower labor, is highly associated with this polymorphism (P<0.0001). Heavier and Black patients had slower latent labor (P<0.01, 0.01) and neuraxial analgesia was associated with slower labor progress (P<0.0001). It could take up to 36 hours for the heaviest and the Black parturients to transition from 1cm cervical dilation to active labor; however once the active phase began, labor rate was the same as other patients’. Conclusion We detected a strong association between β2AR genotype and slower labor. Asian ethnicity may be a proxy for β2AR genotype. Black and heavy women have slower latent labor. These results confirm many of the associations found when this mathematical model was applied to a large retrospectivecohort, further validating this approach to description and analysis of labor progress. PMID:21394004

Serotonin affects association of aversive outcomes to past actions.

PubMed

Tanaka, Saori C; Shishida, Kazuhiro; Schweighofer, Nicolas; Okamoto, Yasumasa; Yamawaki, Shigeto; Doya, Kenji

2009-12-16

Impairment in the serotonergic system has been linked to action choices that are less advantageous in a long run. Such impulsive choices can be caused by a deficit in linking a given reward or punishment with past actions. Here, we tested the effect of manipulation of the serotonergic system by tryptophan depletion and loading on learning the association of current rewards and punishments with past actions. We observed slower associative learning when actions were followed by a delayed punishment in the low serotonergic condition. Furthermore, a model-based analysis revealed a positive correlation between the length of the memory trace for aversive choices and subjects' blood tryptophan concentration. Our results suggest that the serotonergic system regulates the time scale of retrospective association of punishments to past actions.

On Parallelizing Single Dynamic Simulation Using HPC Techniques and APIs of Commercial Software

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diao, Ruisheng; Jin, Shuangshuang; Howell, Frederic

Time-domain simulations are heavily used in today’s planning and operation practices to assess power system transient stability and post-transient voltage/frequency profiles following severe contingencies to comply with industry standards. Because of the increased modeling complexity, it is several times slower than real time for state-of-the-art commercial packages to complete a dynamic simulation for a large-scale model. With the growing stochastic behavior introduced by emerging technologies, power industry has seen a growing need for performing security assessment in real time. This paper presents a parallel implementation framework to speed up a single dynamic simulation by leveraging the existing stability model librarymore » in commercial tools through their application programming interfaces (APIs). Several high performance computing (HPC) techniques are explored such as parallelizing the calculation of generator current injection, identifying fast linear solvers for network solution, and parallelizing data outputs when interacting with APIs in the commercial package, TSAT. The proposed method has been tested on a WECC planning base case with detailed synchronous generator models and exhibits outstanding scalable performance with sufficient accuracy.« less

Executive Attention Impairment in Adolescents With Major Depressive Disorder.

PubMed

Sommerfeldt, Sasha L; Cullen, Kathryn R; Han, Georges; Fryza, Brandon J; Houri, Alaa K; Klimes-Dougan, Bonnie

2016-01-01

Neural network models that guide neuropsychological assessment practices are increasingly used to explicate depression, though a paucity of work has focused on regulatory systems that are under development in adolescence. The purpose of this study was to evaluate subsystems of attention related to executive functioning including alerting, orienting, and executive attention networks, as well as sustained attention with varying working memory load, in a sample of depressed and well adolescents. Neuropsychological functioning in 99 adolescents diagnosed with major depressive disorder (MDD) and 63 adolescent healthy controls (M = 16.6 years old) was assessed on the Attention Network Test (ANT) and the Continuous Performance Test, Identical Pairs. Adolescents with MDD, particularly those who were not medicated, were slower to process conflict (slower reaction time on the Executive Attention scale of the ANT) compared to controls, particularly for those who were not undergoing psychopharmacological treatment. Tentative evidence also suggests that within the MDD group, orienting performance was more impaired in those with a history of comorbid substance use disorder, and alerting was more impaired in those with a history of a suicide attempt. Adolescents with depression showed impaired executive attention, although cognitive performance varied across subgroups of patients. These findings highlight the importance of examining neurocognitive correlates associated with features of depression and suggest an avenue for future research to help guide the development of interventions.

Determining long time-scale hyporheic zone flow paths in Antarctic streams

USGS Publications Warehouse

Gooseff, M.N.; McKnight, Diane M.; Runkel, R.L.; Vaughn, B.H.

2003-01-01

In the McMurdo Dry Valleys of Antarctica, glaciers are the source of meltwater during the austral summer, and the streams and adjacent hyporheic zones constitute the entire physical watershed; there are no hillslope processes in these systems. Hyporheic zones can extend several metres from each side of the stream, and are up to 70 cm deep, corresponding to a lateral cross-section as large as 12 m2, and water resides in the subsurface year around. In this study, we differentiate between the near-stream hyporheic zone, which can be characterized with stream tracer experiments, and the extended hyporheic zone, which has a longer time-scale of exchange. We sampled stream water from Green Creek and from the adjacent saturated alluvium for stable isotopes of D and 18O to assess the significance and extent of stream-water exchange between the streams and extended hyporheic zones over long time-scales (days to weeks). Our results show that water residing in the extended hyporheic zone is much more isotopically enriched (up to 11??? D and 2.2??? 18O) than stream water. This result suggests a long residence time within the extended hyporheic zone, during which fractionation has occured owing to summer evaporation and winter sublimation of hyporheic water. We found less enriched water in the extended hyporheic zone later in the flow season, suggesting that stream water may be exchanged into and out of this zone, on the time-scale of weeks to months. The transient storage model OTIS was used to characterize the exchange of stream water with the extended hyporheic zone. Model results yield exchange rates (??) generally an order magnitude lower (10-5 s-1) than those determined using stream-tracer techniques on the same stream. In light of previous studies in these streams, these results suggest that the hyporheic zones in Antarctic streams have near-stream zones of rapid stream-water exchange, where 'fast' biogeochemical reactions may influence water chemistry, and extended hyporheic zones, in which slower biogeochemical reaction rates may affect stream-water chemistry at longer time-scales. Copyright ?? 2003 John Wiley & Sons, Ltd.

Slow cooling and highly efficient extraction of hot carriers in colloidal perovskite nanocrystals

PubMed Central

Li, Mingjie; Bhaumik, Saikat; Goh, Teck Wee; Kumar, Muduli Subas; Yantara, Natalia; Grätzel, Michael; Mhaisalkar, Subodh; Mathews, Nripan; Sum, Tze Chien

2017-01-01

Hot-carrier solar cells can overcome the Shockley-Queisser limit by harvesting excess energy from hot carriers. Inorganic semiconductor nanocrystals are considered prime candidates. However, hot-carrier harvesting is compromised by competitive relaxation pathways (for example, intraband Auger process and defects) that overwhelm their phonon bottlenecks. Here we show colloidal halide perovskite nanocrystals transcend these limitations and exhibit around two orders slower hot-carrier cooling times and around four times larger hot-carrier temperatures than their bulk-film counterparts. Under low pump excitation, hot-carrier cooling mediated by a phonon bottleneck is surprisingly slower in smaller nanocrystals (contrasting with conventional nanocrystals). At high pump fluence, Auger heating dominates hot-carrier cooling, which is slower in larger nanocrystals (hitherto unobserved in conventional nanocrystals). Importantly, we demonstrate efficient room temperature hot-electrons extraction (up to ∼83%) by an energy-selective electron acceptor layer within 1 ps from surface-treated perovskite NCs thin films. These insights enable fresh approaches for extremely thin absorber and concentrator-type hot-carrier solar cells. PMID:28176882

HIV competition dynamics over sexual networks: first comer advantage conserves founder effects.

PubMed

Ferdinandy, Bence; Mones, Enys; Vicsek, Tamás; Müller, Viktor

2015-02-01

Outside Africa, the global phylogeography of HIV is characterized by compartmentalized local epidemics that are typically dominated by a single subtype, which indicates strong founder effects. We hypothesized that the competition of viral strains at the epidemic level may involve an advantage of the resident strain that was the first to colonize a population. Such an effect would slow down the invasion of new strains, and thus also the diversification of the epidemic. We developed a stochastic modelling framework to simulate HIV epidemics over dynamic contact networks. We simulated epidemics in which the second strain was introduced into a population where the first strain had established a steady-state epidemic, and assessed whether, and on what time scale, the second strain was able to spread in the population. Simulations were parameterized based on empirical data; we tested scenarios with varying levels of overall prevalence. The spread of the second strain occurred on a much slower time scale compared with the initial expansion of the first strain. With strains of equal transmission efficiency, the second strain was unable to invade on a time scale relevant for the history of the HIV pandemic. To become dominant over a time scale of decades, the second strain needed considerable (>25%) advantage in transmission efficiency over the resident strain. The inhibition effect was weaker if the second strain was introduced while the first strain was still in its growth phase. We also tested how possible mechanisms of interference (inhibition of superinfection, depletion of highly connected hubs in the network, one-time acute peak of infectiousness) contribute to the inhibition effect. Our simulations confirmed a strong first comer advantage in the competition dynamics of HIV at the population level, which may explain the global phylogeography of the virus and may influence the future evolution of the pandemic.

Short‐term time step convergence in a climate model

PubMed Central

Rasch, Philip J.; Taylor, Mark A.; Jablonowski, Christiane

2015-01-01

Abstract This paper evaluates the numerical convergence of very short (1 h) simulations carried out with a spectral‐element (SE) configuration of the Community Atmosphere Model version 5 (CAM5). While the horizontal grid spacing is fixed at approximately 110 km, the process‐coupling time step is varied between 1800 and 1 s to reveal the convergence rate with respect to the temporal resolution. Special attention is paid to the behavior of the parameterized subgrid‐scale physics. First, a dynamical core test with reduced dynamics time steps is presented. The results demonstrate that the experimental setup is able to correctly assess the convergence rate of the discrete solutions to the adiabatic equations of atmospheric motion. Second, results from full‐physics CAM5 simulations with reduced physics and dynamics time steps are discussed. It is shown that the convergence rate is 0.4—considerably slower than the expected rate of 1.0. Sensitivity experiments indicate that, among the various subgrid‐scale physical parameterizations, the stratiform cloud schemes are associated with the largest time‐stepping errors, and are the primary cause of slow time step convergence. While the details of our findings are model specific, the general test procedure is applicable to any atmospheric general circulation model. The need for more accurate numerical treatments of physical parameterizations, especially the representation of stratiform clouds, is likely common in many models. The suggested test technique can help quantify the time‐stepping errors and identify the related model sensitivities. PMID:27660669

Modeling flow and transport in fracture networks using graphs

NASA Astrophysics Data System (ADS)

Karra, S.; O'Malley, D.; Hyman, J. D.; Viswanathan, H. S.; Srinivasan, G.

2018-03-01

Fractures form the main pathways for flow in the subsurface within low-permeability rock. For this reason, accurately predicting flow and transport in fractured systems is vital for improving the performance of subsurface applications. Fracture sizes in these systems can range from millimeters to kilometers. Although modeling flow and transport using the discrete fracture network (DFN) approach is known to be more accurate due to incorporation of the detailed fracture network structure over continuum-based methods, capturing the flow and transport in such a wide range of scales is still computationally intractable. Furthermore, if one has to quantify uncertainty, hundreds of realizations of these DFN models have to be run. To reduce the computational burden, we solve flow and transport on a graph representation of a DFN. We study the accuracy of the graph approach by comparing breakthrough times and tracer particle statistical data between the graph-based and the high-fidelity DFN approaches, for fracture networks with varying number of fractures and degree of heterogeneity. Due to our recent developments in capabilities to perform DFN high-fidelity simulations on fracture networks with large number of fractures, we are in a unique position to perform such a comparison. We show that the graph approach shows a consistent bias with up to an order of magnitude slower breakthrough when compared to the DFN approach. We show that this is due to graph algorithm's underprediction of the pressure gradients across intersections on a given fracture, leading to slower tracer particle speeds between intersections and longer travel times. We present a bias correction methodology to the graph algorithm that reduces the discrepancy between the DFN and graph predictions. We show that with this bias correction, the graph algorithm predictions significantly improve and the results are very accurate. The good accuracy and the low computational cost, with O (104) times lower times than the DFN, makes the graph algorithm an ideal technique to incorporate in uncertainty quantification methods.

Modeling flow and transport in fracture networks using graphs.

PubMed

Karra, S; O'Malley, D; Hyman, J D; Viswanathan, H S; Srinivasan, G

2018-03-01

Fractures form the main pathways for flow in the subsurface within low-permeability rock. For this reason, accurately predicting flow and transport in fractured systems is vital for improving the performance of subsurface applications. Fracture sizes in these systems can range from millimeters to kilometers. Although modeling flow and transport using the discrete fracture network (DFN) approach is known to be more accurate due to incorporation of the detailed fracture network structure over continuum-based methods, capturing the flow and transport in such a wide range of scales is still computationally intractable. Furthermore, if one has to quantify uncertainty, hundreds of realizations of these DFN models have to be run. To reduce the computational burden, we solve flow and transport on a graph representation of a DFN. We study the accuracy of the graph approach by comparing breakthrough times and tracer particle statistical data between the graph-based and the high-fidelity DFN approaches, for fracture networks with varying number of fractures and degree of heterogeneity. Due to our recent developments in capabilities to perform DFN high-fidelity simulations on fracture networks with large number of fractures, we are in a unique position to perform such a comparison. We show that the graph approach shows a consistent bias with up to an order of magnitude slower breakthrough when compared to the DFN approach. We show that this is due to graph algorithm's underprediction of the pressure gradients across intersections on a given fracture, leading to slower tracer particle speeds between intersections and longer travel times. We present a bias correction methodology to the graph algorithm that reduces the discrepancy between the DFN and graph predictions. We show that with this bias correction, the graph algorithm predictions significantly improve and the results are very accurate. The good accuracy and the low computational cost, with O(10^{4}) times lower times than the DFN, makes the graph algorithm an ideal technique to incorporate in uncertainty quantification methods.

Modeling flow and transport in fracture networks using graphs

DOE PAGES

Karra, S.; O'Malley, D.; Hyman, J. D.; ...

2018-03-09

Fractures form the main pathways for flow in the subsurface within low-permeability rock. For this reason, accurately predicting flow and transport in fractured systems is vital for improving the performance of subsurface applications. Fracture sizes in these systems can range from millimeters to kilometers. Although modeling flow and transport using the discrete fracture network (DFN) approach is known to be more accurate due to incorporation of the detailed fracture network structure over continuum-based methods, capturing the flow and transport in such a wide range of scales is still computationally intractable. Furthermore, if one has to quantify uncertainty, hundreds of realizationsmore » of these DFN models have to be run. To reduce the computational burden, we solve flow and transport on a graph representation of a DFN. We study the accuracy of the graph approach by comparing breakthrough times and tracer particle statistical data between the graph-based and the high-fidelity DFN approaches, for fracture networks with varying number of fractures and degree of heterogeneity. Due to our recent developments in capabilities to perform DFN high-fidelity simulations on fracture networks with large number of fractures, we are in a unique position to perform such a comparison. We show that the graph approach shows a consistent bias with up to an order of magnitude slower breakthrough when compared to the DFN approach. We show that this is due to graph algorithm's underprediction of the pressure gradients across intersections on a given fracture, leading to slower tracer particle speeds between intersections and longer travel times. We present a bias correction methodology to the graph algorithm that reduces the discrepancy between the DFN and graph predictions. We show that with this bias correction, the graph algorithm predictions significantly improve and the results are very accurate. In conclusion, the good accuracy and the low computational cost, with O(10 4) times lower times than the DFN, makes the graph algorithm an ideal technique to incorporate in uncertainty quantification methods.« less

Modeling flow and transport in fracture networks using graphs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karra, S.; O'Malley, D.; Hyman, J. D.

Fractures form the main pathways for flow in the subsurface within low-permeability rock. For this reason, accurately predicting flow and transport in fractured systems is vital for improving the performance of subsurface applications. Fracture sizes in these systems can range from millimeters to kilometers. Although modeling flow and transport using the discrete fracture network (DFN) approach is known to be more accurate due to incorporation of the detailed fracture network structure over continuum-based methods, capturing the flow and transport in such a wide range of scales is still computationally intractable. Furthermore, if one has to quantify uncertainty, hundreds of realizationsmore » of these DFN models have to be run. To reduce the computational burden, we solve flow and transport on a graph representation of a DFN. We study the accuracy of the graph approach by comparing breakthrough times and tracer particle statistical data between the graph-based and the high-fidelity DFN approaches, for fracture networks with varying number of fractures and degree of heterogeneity. Due to our recent developments in capabilities to perform DFN high-fidelity simulations on fracture networks with large number of fractures, we are in a unique position to perform such a comparison. We show that the graph approach shows a consistent bias with up to an order of magnitude slower breakthrough when compared to the DFN approach. We show that this is due to graph algorithm's underprediction of the pressure gradients across intersections on a given fracture, leading to slower tracer particle speeds between intersections and longer travel times. We present a bias correction methodology to the graph algorithm that reduces the discrepancy between the DFN and graph predictions. We show that with this bias correction, the graph algorithm predictions significantly improve and the results are very accurate. In conclusion, the good accuracy and the low computational cost, with O(10 4) times lower times than the DFN, makes the graph algorithm an ideal technique to incorporate in uncertainty quantification methods.« less

Risk perception influences athletic pacing strategy.

PubMed

Micklewright, Dominic; Parry, David; Robinson, Tracy; Deacon, Greg; Renfree, Andrew; St Clair Gibson, Alan; Matthews, William J

2015-05-01

The objective of this study is to examine risk taking and risk perception associations with perceived exertion, pacing, and performance in athletes. Two experiments were conducted in which risk perception was assessed using the domain-specific risk taking (DOSPERT) scale in 20 novice cyclists (experiment 1) and 32 experienced ultramarathon runners (experiment 2). In experiment 1, participants predicted their pace and then performed a 5-km maximum effort cycling time trial on a calibrated Kingcycle mounted bicycle. Split times and perceived exertion were recorded every kilometer. In experiment 2, each participant predicted their split times before running a 100-km ultramarathon. Split times and perceived exertion were recorded at seven checkpoints. In both experiments, higher and lower risk perception groups were created using median split of DOSPERT scores. In experiment 1, pace during the first kilometer was faster among lower risk perceivers compared with higher risk perceivers (t(18) = 2.0, P = 0.03) and faster among higher risk takers compared with lower risk takers (t(18) = 2.2, P = 0.02). Actual pace was slower than predicted pace during the first kilometer in both the higher risk perceivers (t(9) = -4.2, P = 0.001) and lower risk perceivers (t(9) = -1.8, P = 0.049). In experiment 2, pace during the first 36 km was faster among lower risk perceivers compared with higher risk perceivers (t(16) = 2.0, P = 0.03). Irrespective of risk perception group, actual pace was slower than predicted pace during the first 18 km (t(16) = 8.9, P < 0.001) and from 18 to 36 km (t(16) = 4.0, P < 0.001). In both experiments, there was no difference in performance between higher and lower risk perception groups. Initial pace is associated with an individual's perception of risk, with low perceptions of risk being associated with a faster starting pace. Large differences between predicted and actual pace suggest that the performance template lacks accuracy, perhaps indicating greater reliance on momentary pacing decisions rather than preplanned strategy.

Single Molecule Measurement, a Tool for Exploring the Dynamic Mechanism of Biomolecules

NASA Astrophysics Data System (ADS)

Yanagida, Toshio

Biomolecules fluctuate in response to thermal agitation. These fluctuations are present at various biological levels ranging from single molecules to more complicated systems like perception. Despite thermal fluctuation often being considered noise, in some cases biomolecules actually utilize them to achieve function. How biomolecules do this is necessary to understand the mechanism underlying their function. Thermal noise causes fast, local motion in the time range of picosecond to nanosecond, which drives slower, collective motions [1]. These large, collective motions and conformational transitions are achieved in the time range of microsecond to millisecond, which is the time needed for a biomolecule to exceed its energy barrier in order to switch between two coordinates in its free-energy landscape. These slower conformational or state changes are likely rate limiting for biomolecule function.

Helicity dynamics in stratified turbulence in the absence of forcing.

PubMed

Rorai, C; Rosenberg, D; Pouquet, A; Mininni, P D

2013-06-01

A numerical study of decaying stably stratified flows is performed. Relatively high stratification (Froude number ≈10(-2)-10(-1)) and moderate Reynolds (Re) numbers (Re≈ 3-6×10(3)) are considered and a particular emphasis is placed on the role of helicity (velocity-vorticity correlations), which is not an invariant of the nondissipative equations. The problem is tackled by integrating the Boussinesq equations in a periodic cubical domain using different initial conditions: a nonhelical Taylor-Green (TG) flow, a fully helical Beltrami [Arnold-Beltrami-Childress (ABC)] flow, and random flows with a tunable helicity. We show that for stratified ABC flows helicity undergoes a substantially slower decay than for unstratified ABC flows. This fact is likely associated to the combined effect of stratification and large-scale coherent structures. Indeed, when the latter are missing, as in random flows, helicity is rapidly destroyed by the onset of gravitational waves. A type of large-scale dissipative "cyclostrophic" balance can be invoked to explain this behavior. No production of helicity is observed, contrary to the case of rotating and stratified flows. When helicity survives in the system, it strongly affects the temporal energy decay and the energy distribution among Fourier modes. We discover in fact that the decay rate of energy for stratified helical flows is much slower than for stratified nonhelical flows and can be considered with a phenomenological model in a way similar to what is done for unstratified rotating flows. We also show that helicity, when strong, has a measurable effect on the Fourier spectra, in particular at scales larger than the buoyancy scale, for which it displays a rather flat scaling associated with vertical shear, as observed in the planetary boundary layer.

"Paradox of slow frequencies" - Are slow frequencies in upper cortical layers a neural predisposition of the level/state of consciousness (NPC)?

PubMed

Northoff, Georg

2017-09-01

Consciousness research has much focused on faster frequencies like alpha or gamma while neglecting the slower ones in the infraslow (0.001-0.1Hz) and slow (0.1-1Hz) frequency range. These slower frequency ranges have a "bad reputation" though; their increase in power can observed during the loss of consciousness as in sleep, anesthesia, and vegetative state. However, at the same time, slower frequencies have been conceived instrumental for consciousness. The present paper aims to resolve this paradox which I describe as "paradox of slow frequencies". I first show various data that suggest a central role of slower frequencies in integrating faster ones, i.e., "temporo-spatial integration and nestedness". Such "temporo-spatial integration and nestedness" is disrupted during the loss of consciousness as in anesthesia and sleep leading to "temporo-spatial fragmentation and isolation" between slow and fast frequencies. Slow frequencies are supposedly mediated by neural activity in upper cortical layers in higher-order associative regions as distinguished from lower cortical layers that are related to faster frequencies. Taken together, slower and faster frequencies take on different roles for the level/state of consciousness. Faster frequencies by themselves are sufficient and thus a neural correlate of consciousness (NCC) while slower frequencies are a necessary non-sufficient condition of possible consciousness, e.g., a neural predisposition of the level/state of consciousness (NPC). This resolves the "paradox of slow frequencies" in that it assigns different roles to slower and faster frequencies in consciousness, i.e., NCC and NPC. Taken as NCC and NPC, fast and slow frequencies including their relation as in "temporo-spatial integration and nestedness" can be considered a first "building bloc" of a future "temporo-spatial theory of consciousness" (TTC) (Northoff, 2013; Northoff, 2014b; Northoff & Huang, 2017). Copyright © 2017 Elsevier Inc. All rights reserved.

Habitat use by a Midwestern U.S.A. riverine fish assemblage: effects of season, water temperature and river discharge

USGS Publications Warehouse

Gillette, D.P.; Tiemann, J.S.; Edds, D.R.; Wildhaber, M.L.

2006-01-01

The hypothesis that temperate stream fishes alter habitat use in response to changing water temperature and stream discharge was evaluated over a 1 year period in the Neosho River, Kansas, U.S.A. at two spatial scales. Winter patterns differed from those of all other seasons, with shallower water used less frequently, and low-flow habitat more frequently, than at other times. Non-random habitat use was more frequent at the point scale (4.5 m2) than at the larger reach scale (20-40 m), although patterns at both scales were similar. Relative to available habitats, assemblages used shallower, swifter-flowing water as temperature increased, and shallower, slower-flowing water as river discharge increased. River discharge had a stronger effect on assemblage habitat use than water temperature. Proportion of juveniles in the assemblage did not have a significant effect. This study suggests that many riverine fishes shift habitats in response to changing environmental conditions, and supports, at the assemblage level, the paradigm of lotic fishes switching from shallower, high-velocity habitats in summer to deeper, low-velocity habitats in winter, and of using shallower, low-velocity habitats during periods of high discharge. Results also indicate that different species within temperate river fish assemblages show similar habitat use patterns at multiple scales in response to environmental gradients, but that non-random use of available habitats is more frequent at small scales. ?? 2006 The Fisheries Society of the British Isles.

Droplet charging regimes for ultrasonic atomization of a liquid electrolyte in an external electric field.

PubMed

Forbes, Thomas P; Degertekin, F Levent; Fedorov, Andrei G

2011-01-01

Distinct regimes of droplet charging, determined by the dominant charge transport process, are identified for an ultrasonic droplet ejector using electrohydrodynamic computational simulations, a fundamental scale analysis, and experimental measurements. The regimes of droplet charging are determined by the relative magnitudes of the dimensionless Strouhal and electric Reynolds numbers, which are a function of the process (pressure forcing), advection, and charge relaxation time scales for charge transport. Optimal (net maximum) droplet charging has been identified to exist for conditions in which the electric Reynolds number is of the order of the inverse Strouhal number, i.e., the charge relaxation time is on the order of the pressure forcing (droplet formation) time scale. The conditions necessary for optimal droplet charging have been identified as a function of the dimensionless Debye number (i.e., liquid conductivity), external electric field (magnitude and duration), and atomization drive signal (frequency and amplitude). The specific regime of droplet charging also determines the functional relationship between droplet charge and charging electric field strength. The commonly expected linear relationship between droplet charge and external electric field strength is only found when either the inverse of the Strouhal number is less than the electric Reynolds number, i.e., the charge relaxation is slower than both the advection and external pressure forcing, or in the electrostatic limit, i.e., when charge relaxation is much faster than all other processes. The analysis provides a basic understanding of the dominant physics of droplet charging with implications to many important applications, such as electrospray mass spectrometry, ink jet printing, and drop-on-demand manufacturing.

Droplet charging regimes for ultrasonic atomization of a liquid electrolyte in an external electric field

PubMed Central

Forbes, Thomas P.; Degertekin, F. Levent; Fedorov, Andrei G.

2011-01-01

Distinct regimes of droplet charging, determined by the dominant charge transport process, are identified for an ultrasonic droplet ejector using electrohydrodynamic computational simulations, a fundamental scale analysis, and experimental measurements. The regimes of droplet charging are determined by the relative magnitudes of the dimensionless Strouhal and electric Reynolds numbers, which are a function of the process (pressure forcing), advection, and charge relaxation time scales for charge transport. Optimal (net maximum) droplet charging has been identified to exist for conditions in which the electric Reynolds number is of the order of the inverse Strouhal number, i.e., the charge relaxation time is on the order of the pressure forcing (droplet formation) time scale. The conditions necessary for optimal droplet charging have been identified as a function of the dimensionless Debye number (i.e., liquid conductivity), external electric field (magnitude and duration), and atomization drive signal (frequency and amplitude). The specific regime of droplet charging also determines the functional relationship between droplet charge and charging electric field strength. The commonly expected linear relationship between droplet charge and external electric field strength is only found when either the inverse of the Strouhal number is less than the electric Reynolds number, i.e., the charge relaxation is slower than both the advection and external pressure forcing, or in the electrostatic limit, i.e., when charge relaxation is much faster than all other processes. The analysis provides a basic understanding of the dominant physics of droplet charging with implications to many important applications, such as electrospray mass spectrometry, ink jet printing, and drop-on-demand manufacturing. PMID:21301636

Time to Cooling Is Associated with Resuscitation Outcomes

PubMed Central

Janata, Andreas; Peacock, W. Frank; Deal, Nathan S.; Kalra, Sarathi; Sterz, Fritz

2016-01-01

Our purpose was to analyze evidence related to timing of cooling from studies of targeted temperature management (TTM) after return of spontaneous circulation (ROSC) after cardiac arrest and to recommend directions for future therapy optimization. We conducted a preliminary review of studies of both animals and patients treated with post-ROSC TTM and hypothesized that a more rapid cooling strategy in the absence of volume-adding cold infusions would provide improved outcomes in comparison with slower cooling. We defined rapid cooling as the achievement of 34°C within 3.5 hours of ROSC without the use of volume-adding cold infusions, with a ≥3.0°C/hour rate of cooling. Using the PubMed database and a previously published systematic review, we identified clinical studies published from 2002 through 2014 related to TTM. Analysis included studies with time from collapse to ROSC of 20–30 minutes, reporting of time from ROSC to target temperature and rate of patients in ventricular tachycardia or ventricular fibrillation, and hypothermia maintained for 20–24 hours. The use of cardiopulmonary bypass as a cooling method was an exclusion criterion for this analysis. We compared all rapid cooling studies with all slower cooling studies of ≥100 patients. Eleven studies were initially identified for analysis, comprising 4091 patients. Two additional studies totaling 609 patients were added based on availability of unpublished data, bringing the total to 13 studies of 4700 patients. Outcomes for patients, dichotomized into faster and slower cooling approaches, were determined using weighted linear regression using IBM SPSS Statistics software. Rapid cooling without volume-adding cold infusions yielded a higher rate of good neurological recovery than slower cooling methods. Attainment of a temperature below 34°C within 3.5 hours of ROSC and using a cooling rate of more than 3°C/hour appear to be beneficial. PMID:27906641

NOAA Coral Reef Watch: Decision Support Tools for Coral Reef Managers

NASA Astrophysics Data System (ADS)

Rauenzahn, J.; Eakin, C.; Skirving, W. J.; Burgess, T.; Christensen, T.; Heron, S. F.; Li, J.; Liu, G.; Morgan, J.; Nim, C.; Parker, B. A.; Strong, A. E.

2010-12-01

A multitude of natural and anthropogenic stressors exert substantial influence on coral reef ecosystems and contribute to bleaching events, slower coral growth, infectious disease outbreaks, and mortality. Satellite-based observations can monitor, at a global scale, environmental conditions that influence both short-term and long-term coral reef ecosystem health. From research to operations, NOAA Coral Reef Watch (CRW) incorporates paleoclimatic, in situ, and satellite-based biogeophysical data to provide near-real-time and forecast information and tools to help managers, researchers, and other stakeholders interpret coral health and stress. CRW has developed an operational, near-real-time product suite that includes sea surface temperature (SST), SST time series data, SST anomaly charts, coral bleaching HotSpots, and Degree Heating Weeks (DHW). Bi-weekly global SST analyses are based on operational nighttime-only SST at 50-km resolution. CRW is working to develop high-resolution products to better address thermal stress on finer scales and is applying climate models to develop seasonal outlooks of coral bleaching. Automated Satellite Bleaching Alerts (SBAs), available at Virtual Stations worldwide, provide the only global early-warning system to notify managers of changing reef environmental conditions. Currently, CRW is collaborating with numerous domestic and international partners to develop new tools to address ocean acidification, infectious diseases of corals, combining light and temperature to detect coral photosystem stress, and other parameters.

Maternal Obesity and Excessive Gestational Weight Gain Are Associated with Components of Child Cognition.

PubMed

Pugh, Sarah J; Richardson, Gale A; Hutcheon, Jennifer A; Himes, Katherine P; Brooks, Maria M; Day, Nancy L; Bodnar, Lisa M

2015-11-01

Maternal overweight and obesity affect two-thirds of women of childbearing age and may increase the risk of impaired child cognition. Our objective was to test the hypothesis that high/low gestational weight gain (GWG) and high/low prepregnancy BMI were associated with offspring intelligence quotient (IQ) and executive function at age 10. Mother-infant dyads (n = 763) enrolled in a birth cohort study were followed from early pregnancy to 10 y postpartum. IQ was assessed by trained examiners with the use of the Stanford Binet Intelligence Scale-4th edition. Executive function was assessed by the number of perseverative errors on the Wisconsin Card Sorting Test and time to complete Part B on the Trail Making Test. Self-reported total GWG was converted to gestational-age-standardized GWG z score. Multivariable linear regression and negative binomial regression were used to estimate independent and joint effects of GWG and BMI on outcomes while adjusting for covariates. At enrollment, the majority of women in the Maternal Health Practices and Child Development cohort were unmarried and unemployed, and more than one-half reported their race as black. The mean ± SD GWG z score was -0.5 ± 1.8, and 27% of women had a pregravid BMI ≥ 25. The median (IQR) number of perseverative errors was 23 (17, 29), the mean ± SD time on Part B was 103 ± 42.6 s, and 44% of children had a low average IQ (≤ 89). Maternal obesity was associated with 3.2 lower IQ points (95% CI: -5.6, -0.8) and a slower time to complete the executive function scale Part B (adjusted β: 12.7 s; 95% CI: 2.8, 23 s) compared with offspring of normal-weight mothers. Offspring of mothers whose GWG was >+1 SD, compared with -1 to +1 SD, performed 15 s slower on the executive function task (95% CI: 1.8, 28 s). There was no association between GWG z score and offspring composite IQ score (adjusted β: -0.32; 95% CI: -0.72, 0.10). Prepregnancy BMI did not modify these associations. Although GWG may be important for executive function, maternal BMI has a stronger relation than GWG to both offspring intelligence and executive function. Our findings contribute to evidence linking maternal obesity to long-term child outcomes. © 2015 American Society for Nutrition.

Gait initiation time is associated with the risk of multiple falls-A population-based study.

PubMed

Callisaya, Michele L; Blizzard, Leigh; Martin, Kara; Srikanth, Velandai K

2016-09-01

In a population-based study of older people to examine whether 1) overall gait initiation (GI) time or its components are associated with falls and 2) GI under dual-task is a stronger predictor of falls risk than under single-task. Participants aged 60-85 years were randomly selected from the electoral roll. GI was obtained with a force platform under both single and dual-task conditions. Falls were ascertained prospectively over a 12-month period. Log multinomial regression was used to examine the association between GI time (total and its components) and risk of single and multiple falls. Age, sex and physiological and cognitive falls risk factors were considered as confounders. The mean age of the sample (n=124) was 71.0 (SD 6.8) years and 58.9% (n=73) were male. Over 12 months 21.8% (n=27) of participants reported a single fall and 16.1% (n=20) reported multiple falls. Slower overall GI time under both single (RR all per 100ms 1.28, 95%CI 1.03, 1.58) and dual-task (RR 1.14, 95%CI 1.02, 1.27) was associated with increased risk of multiple, but not single falls (p<0.05). Multiple falls were also associated with slower time to first lateral movement under single-task (RR 1.90 95%CI 0.59, 1.51) and swing time under dual-task condition (RR 1.44 95%CI 1.08, 1.94). Slower GI time is associated with the risk of multiple falls independent of other risk factors, suggesting it could be used as part of a comprehensive falls assessment. Time to the first lateral movement under single-task may be the best measures of this risk. Copyright © 2016 Elsevier B.V. All rights reserved.

Diabetic ketoacidosis in adult patients: an audit of factors influencing time to normalisation of metabolic parameters.

PubMed

Lee, Melissa H; Calder, Genevieve L; Santamaria, John D; MacIsaac, Richard J

2018-05-01

Diabetic ketoacidosis (DKA) is an acute life-threatening metabolic complication of diabetes that imposes substantial burden on our healthcare system. There is a paucity of published data in Australia assessing factors influencing time to resolution of DKA and length of stay (LOS). To identify factors that predict a slower time to resolution of DKA in adults with diabetes. Retrospective audit of patients admitted to St Vincent's Hospital Melbourne between 2010 to 2014 coded with a diagnosis of 'Diabetic Ketoacidosis'. The primary outcome was time to resolution of DKA based on normalisation of biochemical markers. Episodes of DKA within the wider Victorian hospital network were also explored. Seventy-one patients met biochemical criteria for DKA; median age 31 years (26-45 years), 59% were male and 23% had newly diagnosed diabetes. Insulin omission was the most common precipitant (42%). Median time to resolution of DKA was 11 h (6.5-16.5 h). Individual factors associated with slower resolution of DKA were lower admission pH (P < 0.001) and higher admission serum potassium level (P = 0.03). Median LOS was 3 days (2-5 days), compared to a Victorian state-wide LOS of 2 days. Higher comorbidity scores were associated with longer LOS (P < 0.001). Lower admission pH levels and higher admission serum potassium levels are independent predictors of slower time to resolution of DKA. This may assist to stratify patients with DKA using markers of severity to determine who may benefit from closer monitoring and to predict LOS. © 2018 Royal Australasian College of Physicians.

A cross-sectional controlled developmental study of neuropsychological functions in patients with glutaric aciduria type I.

PubMed

Boy, Nikolas; Heringer, Jana; Haege, Gisela; Glahn, Esther M; Hoffmann, Georg F; Garbade, Sven F; Kölker, Stefan; Burgard, Peter

2015-12-22

Glutaric aciduria type I (GA-I) is an inherited metabolic disease due to deficiency of glutaryl-CoA dehydrogenase (GCDH). Cognitive functions are generally thought to be spared, but have not yet been studied in detail. Thirty patients detected by newborn screening (n = 13), high-risk screening (n = 3) or targeted metabolic testing (n = 14) were studied for simple reaction time (SRT), continuous performance (CP), visual working memory (VWM), visual-motor coordination (Tracking) and visual search (VS). Dystonia (n = 13 patients) was categorized using the Barry-Albright-Dystonia Scale (BADS). Patients were compared with 196 healthy controls. Developmental functions of cognitive performances were analysed using a negative exponential function model. BADS scores correlated with speed tests but not with tests measuring stability or higher cognitive functions without time constraints. Developmental functions of GA-I patients significantly differed from controls for SRT and VS but not for VWM and showed obvious trends for CP and Tracking. Dystonic patients were slower in SRT and CP but reached their asymptote of performance similar to asymptomatic patients and controls in all tests. Asymptomatic patients did not differ from controls, except showing significantly better results in Tracking and a trend for slower reactions in visual search. Data across all age groups of patients and controls fitted well to a model of negative exponential development. Dystonic patients predominantly showed motor speed impairment, whereas performance improved with higher cognitive load. Patients without motor symptoms did not differ from controls. Developmental functions of cognitive performances were similar in patients and controls. Performance in tests with higher cognitive demand might be preserved in GA-I, even in patients with striatal degeneration.

Massive star evolution and SN 1987A

NASA Technical Reports Server (NTRS)

Arnett, David

1991-01-01

The evolution of massive stars through hydrogen and helium burning is addressed. A set of stellar evolutionary sequences for mass/solar mass of 15, 20, and 25, and metallicity of 0.002, 0.005, 0.007, 0.010, and 0.20 are presented; semiconvection is restricted to operating slower than the local thermal time scale. Using these sequences, simple models of the massive star content of the LMC are found to agree moderately well with the new observational data of Fitzpatrick and Garmany (1990). LMC supergiants were detected only in their postmain-sequence phases, so that 5-10 times more massive stars are there but not identified as such. It is argued that SN 1987A exhibits the normal evolution of a single star of about 20 solar mases having LMC abundances. Despite the variety of envelope behavior, the structure of the core at collapse is rather similar for the stars of a given mass. Variations due to different rates of mass loss are likely to be larger than those due to composition.

Uncovering Droop Control Laws Embedded Within the Nonlinear Dynamics of Van der Pol Oscillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sinha, Mohit; Dorfler, Florian; Johnson, Brian B.

This paper examines the dynamics of power-electronic inverters in islanded microgrids that are controlled to emulate the dynamics of Van der Pol oscillators. The general strategy of controlling inverters to emulate the behavior of nonlinear oscillators presents a compelling time-domain alternative to ubiquitous droop control methods which presume the existence of a quasistationary sinusoidal steady state and operate on phasor quantities. We present two main results in this paper. First, by leveraging the method of periodic averaging, we demonstrate that droop laws are intrinsically embedded within a slower time scale in the nonlinear dynamics of Van der Pol oscillators. Second,more » we establish the global convergence of amplitude and phase dynamics in a resistive network interconnecting inverters controlled as Van der Pol oscillators. Furthermore, under a set of nonrestrictive decoupling approximations, we derive sufficient conditions for local exponential stability of desirable equilibria of the linearized amplitude and phase dynamics.« less

Floquet prethermalization and regimes of heating in a periodically driven, interacting quantum system

NASA Astrophysics Data System (ADS)

Weidinger, Simon; Knap, Michael

We study the regimes of heating in the periodically driven O (N) -model, which represents a generic model for interacting quantum many-body systems. By computing the absorbed energy with a non-equilibrium Keldysh Green's function approach, we establish three dynamical regimes: at short times a single-particle dominated regime, at intermediate times a stable Floquet prethermal regime in which the system ceases to absorb, and at parametrically late times a thermalizing regime. Our simulations suggest that in the thermalizing regime the absorbed energy grows algebraically in time with an the exponent that approaches the universal value of 1 / 2 , and is thus significantly slower than linear Joule heating. Our results demonstrate the parametric stability of prethermal states in a generic many-body system driven at frequencies that are comparable to its microscopic scales. This paves the way for realizing exotic quantum phases, such as time crystals or interacting topological phases, in the prethermal regime of interacting Floquet systems. We acknowledge support from the Technical University of Munich - Institute for Advanced Study, funded by the German Excellence Initiative and the European Union FP7 under Grant agreement 291763, and from the DFG Grant No. KN 1254/1-1.

The evolution and devolution of cognitive control: The costs of deliberation in a competitive world

PubMed Central

Tomlin, Damon; Rand, David G.; Ludvig, Elliot A.; Cohen, Jonathan D.

2015-01-01

Dual-system theories of human cognition, under which fast automatic processes can complement or compete with slower deliberative processes, have not typically been incorporated into larger scale population models used in evolutionary biology, macroeconomics, or sociology. However, doing so may reveal important phenomena at the population level. Here, we introduce a novel model of the evolution of dual-system agents using a resource-consumption paradigm. By simulating agents with the capacity for both automatic and controlled processing, we illustrate how controlled processing may not always be selected over rigid, but rapid, automatic processing. Furthermore, even when controlled processing is advantageous, frequency-dependent effects may exist whereby the spread of control within the population undermines this advantage. As a result, the level of controlled processing in the population can oscillate persistently, or even go extinct in the long run. Our model illustrates how dual-system psychology can be incorporated into population-level evolutionary models, and how such a framework can be used to examine the dynamics of interaction between automatic and controlled processing that transpire over an evolutionary time scale. PMID:26078086

The evolution and devolution of cognitive control: The costs of deliberation in a competitive world.

PubMed

Tomlin, Damon; Rand, David G; Ludvig, Elliot A; Cohen, Jonathan D

2015-06-16

Dual-system theories of human cognition, under which fast automatic processes can complement or compete with slower deliberative processes, have not typically been incorporated into larger scale population models used in evolutionary biology, macroeconomics, or sociology. However, doing so may reveal important phenomena at the population level. Here, we introduce a novel model of the evolution of dual-system agents using a resource-consumption paradigm. By simulating agents with the capacity for both automatic and controlled processing, we illustrate how controlled processing may not always be selected over rigid, but rapid, automatic processing. Furthermore, even when controlled processing is advantageous, frequency-dependent effects may exist whereby the spread of control within the population undermines this advantage. As a result, the level of controlled processing in the population can oscillate persistently, or even go extinct in the long run. Our model illustrates how dual-system psychology can be incorporated into population-level evolutionary models, and how such a framework can be used to examine the dynamics of interaction between automatic and controlled processing that transpire over an evolutionary time scale.

The Effects of Attentional Engagement on Route Learning Performance in a Virtual Environment: An Aging Study

PubMed Central

Hartmeyer, Steffen; Grzeschik, Ramona; Wolbers, Thomas; Wiener, Jan M.

2017-01-01

Route learning is a common navigation task affected by cognitive aging. Here we present a novel experimental paradigm to investigate whether age-related declines in executive control of attention contributes to route learning deficits. A young and an older participant group was repeatedly presented with a route through a virtual maze comprised of 12 decision points (DP) and non-decision points (non-DP). To investigate attentional engagement with the route learning task, participants had to respond to auditory probes at both DP and non-DP. Route knowledge was assessed by showing participants screenshots or landmarks from DPs and non-DPs and asking them to indicate the movement direction required to continue the route. Results demonstrate better performance for DPs than for non-DPs and slower responses to auditory probes at DPs compared to non-DPs. As expected we found slower route learning and slower responses to the auditory probes in the older participant group. Interestingly, differences in response times to the auditory probes between DPs and non-DPs can predict the success of route learning in both age groups and may explain slower knowledge acquisition in the older participant group. PMID:28775689

Polymer Chain Conformation and Dynamical Confinement in a Model One-Component Nanocomposite

NASA Astrophysics Data System (ADS)

Mark, C.; Holderer, O.; Allgaier, J.; Hübner, E.; Pyckhout-Hintzen, W.; Zamponi, M.; Radulescu, A.; Feoktystov, A.; Monkenbusch, M.; Jalarvo, N.; Richter, D.

2017-07-01

We report a neutron-scattering investigation on the structure and dynamics of a single-component nanocomposite based on SiO2 particles that were grafted with polyisoprene chains at the entanglement limit. By skillful labeling, we access both the monomer density in the corona as well as the conformation of the grafted chains. While the corona profile follows a r-1 power law, the conformation of a grafted chain is identical to that of a chain in a reference melt, implying a high mutual penetration of the coronas from different particles. The brush crowding leads to topological confinement of the chain dynamics: (i) At local scales, the segmental dynamics is unchanged compared to the reference melt, while (ii) at the scale of the chain, the dynamics appears to be slowed down; (iii) by performing a mode analysis in terms of end-fixed Rouse chains, the slower dynamics is tracked to topological confinement within the cone spanned by the adjacent grafts; (iv) by adding 50% matrix chains, the topological confinement sensed by the grafted chain is lifted partially and the apparent chain motion is accelerated. We observe a crossover from pure Rouse motion at short times to topological confined motion beyond the time when the segmental mean squared displacement has reached the distance to the next graft.

Quantum Hooke's Law to classify pulse laser induced ultrafast melting

DOE PAGES

Hu, Hao; Ding, Hepeng; Liu, Feng

2015-02-03

Ultrafast crystal-to-liquid phase transition induced by femtosecond pulse laser excitation is an interesting material's behavior manifesting the complexity of light-matter interaction. There exist two types of such phase transitions: one occurs at a time scale shorter than a picosecond via a nonthermal process mediated by electron-hole plasma formation; the other at a longer time scale via a thermal melting process mediated by electron-phonon interaction. However, it remains unclear what material would undergo which process and why? Here, by exploiting the property of quantum electronic stress (QES) governed by quantum Hooke's law, we classify the transitions by two distinct classes ofmore » materials: the faster nonthermal process can only occur in materials like ice having an anomalous phase diagram characterized with dT m/dP < 0, where T m is the melting temperature and P is pressure, above a high threshold laser fluence; while the slower thermal process may occur in all materials. Especially, the nonthermal transition is shown to be induced by the QES, acting like a negative internal pressure, which drives the crystal into a “super pressing” state to spontaneously transform into a higher-density liquid phase. Our findings significantly advance fundamental understanding of ultrafast crystal-to-liquid phase transitions, enabling quantitative a priori predictions.« less

Quantum Hooke's Law to Classify Pulse Laser Induced Ultrafast Melting

NASA Astrophysics Data System (ADS)

Hu, Hao; Ding, Hepeng; Liu, Feng

2015-02-01

Ultrafast crystal-to-liquid phase transition induced by femtosecond pulse laser excitation is an interesting material's behavior manifesting the complexity of light-matter interaction. There exist two types of such phase transitions: one occurs at a time scale shorter than a picosecond via a nonthermal process mediated by electron-hole plasma formation; the other at a longer time scale via a thermal melting process mediated by electron-phonon interaction. However, it remains unclear what material would undergo which process and why? Here, by exploiting the property of quantum electronic stress (QES) governed by quantum Hooke's law, we classify the transitions by two distinct classes of materials: the faster nonthermal process can only occur in materials like ice having an anomalous phase diagram characterized with dTm/dP < 0, where Tm is the melting temperature and P is pressure, above a high threshold laser fluence; while the slower thermal process may occur in all materials. Especially, the nonthermal transition is shown to be induced by the QES, acting like a negative internal pressure, which drives the crystal into a ``super pressing'' state to spontaneously transform into a higher-density liquid phase. Our findings significantly advance fundamental understanding of ultrafast crystal-to-liquid phase transitions, enabling quantitative a priori predictions.

Quantum Hooke's Law to Classify Pulse Laser Induced Ultrafast Melting

PubMed Central

Hu, Hao; Ding, Hepeng; Liu, Feng

2015-01-01

Ultrafast crystal-to-liquid phase transition induced by femtosecond pulse laser excitation is an interesting material's behavior manifesting the complexity of light-matter interaction. There exist two types of such phase transitions: one occurs at a time scale shorter than a picosecond via a nonthermal process mediated by electron-hole plasma formation; the other at a longer time scale via a thermal melting process mediated by electron-phonon interaction. However, it remains unclear what material would undergo which process and why? Here, by exploiting the property of quantum electronic stress (QES) governed by quantum Hooke's law, we classify the transitions by two distinct classes of materials: the faster nonthermal process can only occur in materials like ice having an anomalous phase diagram characterized with dTm/dP < 0, where Tm is the melting temperature and P is pressure, above a high threshold laser fluence; while the slower thermal process may occur in all materials. Especially, the nonthermal transition is shown to be induced by the QES, acting like a negative internal pressure, which drives the crystal into a “super pressing” state to spontaneously transform into a higher-density liquid phase. Our findings significantly advance fundamental understanding of ultrafast crystal-to-liquid phase transitions, enabling quantitative a priori predictions. PMID:25645258

Quantum Hooke's law to classify pulse laser induced ultrafast melting.

PubMed

Hu, Hao; Ding, Hepeng; Liu, Feng

2015-02-03

Ultrafast crystal-to-liquid phase transition induced by femtosecond pulse laser excitation is an interesting material's behavior manifesting the complexity of light-matter interaction. There exist two types of such phase transitions: one occurs at a time scale shorter than a picosecond via a nonthermal process mediated by electron-hole plasma formation; the other at a longer time scale via a thermal melting process mediated by electron-phonon interaction. However, it remains unclear what material would undergo which process and why? Here, by exploiting the property of quantum electronic stress (QES) governed by quantum Hooke's law, we classify the transitions by two distinct classes of materials: the faster nonthermal process can only occur in materials like ice having an anomalous phase diagram characterized with dTm/dP < 0, where Tm is the melting temperature and P is pressure, above a high threshold laser fluence; while the slower thermal process may occur in all materials. Especially, the nonthermal transition is shown to be induced by the QES, acting like a negative internal pressure, which drives the crystal into a "super pressing" state to spontaneously transform into a higher-density liquid phase. Our findings significantly advance fundamental understanding of ultrafast crystal-to-liquid phase transitions, enabling quantitative a priori predictions.

Low temperature dissolution flowsheet for Pu metal

DOE PAGES

Daniel, Jr., William E.; Almond, Philip M.; Rudisill, Tracy S.

2017-06-30

The Savannah River National Laboratory was requested to develop a Pu metal dissolution flowsheet at two reduced temperature ranges for implementation in the Savannah River Site H-Canyon facility. The dissolution and H 2 generation rates during Pu metal dissolution were investigated using a dissolving solution at ambient temperature (20–30°C) and for an intermediate temperature of 50–60°C. The Pu metal dissolution rate measured at 57°C was approximately 20 times slower than at boiling (112–116°C). As a result, the dissolution rate at ambient temperature (24°C) was approximately 80 times slower than the dissolution rate at boiling. Hydrogen concentrations were less than detectablemore » (<0.1 vol%).« less

Real-Time In Vivo Imaging of Butterfly Wing Development: Revealing the Cellular Dynamics of the Pupal Wing Tissue

PubMed Central

Iwata, Masaki; Ohno, Yoshikazu; Otaki, Joji M.

2014-01-01

Butterfly wings are covered with regularly arranged single-colored scales that are formed at the pupal stage. Understanding pupal wing development is therefore crucial to understand wing color pattern formation. Here, we successfully employed real-time in vivo imaging techniques to observe pupal hindwing development over time in the blue pansy butterfly, Junonia orithya. A transparent sheet of epithelial cells that were not yet regularly arranged was observed immediately after pupation. Bright-field imaging and autofluorescent imaging revealed free-moving hemocytes and tracheal branches of a crinoid-like structure underneath the epithelium. The wing tissue gradually became gray-white, epithelial cells were arranged regularly, and hemocytes disappeared, except in the bordering lacuna, after which scales grew. The dynamics of the epithelial cells and scale growth were also confirmed by fluorescent imaging. Fluorescent in vivo staining further revealed that these cells harbored many mitochondria at the surface of the epithelium. Organizing centers for the border symmetry system were apparent immediately after pupation, exhibiting a relatively dark optical character following treatment with fluorescent dyes, as well as in autofluorescent images. The wing tissue exhibited slow and low-frequency contraction pulses with a cycle of approximately 10 to 20 minutes, mainly occurring at 2 to 3 days postpupation. The pulses gradually became slower and weaker and eventually stopped. The wing tissue area became larger after contraction, which also coincided with an increase in the autofluorescence intensity that might have been caused by scale growth. Examination of the pattern of color development revealed that the black pigment was first deposited in patches in the central areas of an eyespot black ring and a parafocal element. These results of live in vivo imaging that covered wide wing area for a long time can serve as a foundation for studying the cellular dynamics of living wing tissues in butterflies. PMID:24586829

Real-time in vivo imaging of butterfly wing development: revealing the cellular dynamics of the pupal wing tissue.

PubMed

Iwata, Masaki; Ohno, Yoshikazu; Otaki, Joji M

2014-01-01

Butterfly wings are covered with regularly arranged single-colored scales that are formed at the pupal stage. Understanding pupal wing development is therefore crucial to understand wing color pattern formation. Here, we successfully employed real-time in vivo imaging techniques to observe pupal hindwing development over time in the blue pansy butterfly, Junonia orithya. A transparent sheet of epithelial cells that were not yet regularly arranged was observed immediately after pupation. Bright-field imaging and autofluorescent imaging revealed free-moving hemocytes and tracheal branches of a crinoid-like structure underneath the epithelium. The wing tissue gradually became gray-white, epithelial cells were arranged regularly, and hemocytes disappeared, except in the bordering lacuna, after which scales grew. The dynamics of the epithelial cells and scale growth were also confirmed by fluorescent imaging. Fluorescent in vivo staining further revealed that these cells harbored many mitochondria at the surface of the epithelium. Organizing centers for the border symmetry system were apparent immediately after pupation, exhibiting a relatively dark optical character following treatment with fluorescent dyes, as well as in autofluorescent images. The wing tissue exhibited slow and low-frequency contraction pulses with a cycle of approximately 10 to 20 minutes, mainly occurring at 2 to 3 days postpupation. The pulses gradually became slower and weaker and eventually stopped. The wing tissue area became larger after contraction, which also coincided with an increase in the autofluorescence intensity that might have been caused by scale growth. Examination of the pattern of color development revealed that the black pigment was first deposited in patches in the central areas of an eyespot black ring and a parafocal element. These results of live in vivo imaging that covered wide wing area for a long time can serve as a foundation for studying the cellular dynamics of living wing tissues in butterflies.

The relationship between medical impairments and arithmetic development in children with cerebral palsy.

PubMed

Jenks, Kathleen M; van Lieshout, Ernest C D M; de Moor, Jan

2009-05-01

Arithmetic ability was tested in children with cerebral palsy without severe intellectual impairment (verbal IQ >or= 70) attending special (n = 41) or mainstream education (n = 16) as well as control children in mainstream education (n = 16) throughout first and second grade. Children with cerebral palsy in special education did not appear to have fully automatized arithmetic facts by the end of second grade. Their lower accuracy and consistently slower (verbal) response times raise important concerns for their future arithmetic development. Differences in arithmetic performance between children with cerebral palsy in special or mainstream education were not related to localization of cerebral palsy or to gross motor impairment. Rather, lower accuracy and slower verbal responses were related to differences in nonverbal intelligence and the presence of epilepsy. Left-hand impairment was related to slower verbal responses but not to lower accuracy.

Vibrational Dynamics of Interfacial Water by Free Induction Decay Sum Frequency Generation (FID-SFG) at the Al2O3(1120)/H2O Interface.

PubMed

Boulesbaa, Abdelaziz; Borguet, Eric

2014-02-06

The dephasing dynamics of a vibrational coherence may reveal the interactions of chemical functional groups with their environment. To investigate this process at a surface, we employ free induction decay sum frequency generation (FID-SFG) to measure the time that it takes for free OH stretch oscillators at the charged (pH ≈ 13, KOH) interface of alumina/water (Al2O3/H2O) to lose their collective coherence. By employing noncollinear optical parametric amplification (NOPA) technology and nonlinear vibrational spectroscopy, we showed that the single free OH peak actually corresponds to two distinct oscillators oriented opposite to each other and measured the total dephasing time, T2, of the free OH stretch modes at the Al2O3/H2O interface with a sub-40 fs temporal resolution. Our results suggested that the free OH oscillators associated with interfacial water dephase on the time scale of 89.4 ± 6.9 fs, whereas the homogeneous dephasing of interfacial alumina hydroxyls is an order of magnitude slower.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zarzycki, Piotr P.; Rosso, Kevin M.

Replica Kinetic Monte Carlo simulations were used to study the characteristic time scales of potentiometric titration of the metal oxides and (oxy)hydroxides. The effect of surface heterogeneity and surface transformation on the titration kinetics were also examined. Two characteristic relaxation times are often observed experimentally, with the trailing slower part attributed to surface non-uniformity, porosity, polymerization, amorphization, and other dynamic surface processes induced by unbalanced surface charge. However, our simulations show that these two characteristic relaxation times are intrinsic to the proton binding reaction for energetically homogeneous surfaces, and therefore surface heterogeneity or transformation do not necessarily need to bemore » invoked. However, all such second-order surface processes are found to intensify the separation and distinction of the two kinetic regimes. The effect of surface energetic-topographic non-uniformity, as well dynamic surface transformation, interface roughening/smoothing were described in a statistical fashion. Furthermore, our simulations show that a shift in the point-of-zero charge is expected from increased titration speed and the pH-dependence of the titration measurement error is in excellent agreement with experimental studies.« less

Atomic-level characterization of the structural dynamics of proteins.

PubMed

Shaw, David E; Maragakis, Paul; Lindorff-Larsen, Kresten; Piana, Stefano; Dror, Ron O; Eastwood, Michael P; Bank, Joseph A; Jumper, John M; Salmon, John K; Shan, Yibing; Wriggers, Willy

2010-10-15

Molecular dynamics (MD) simulations are widely used to study protein motions at an atomic level of detail, but they have been limited to time scales shorter than those of many biologically critical conformational changes. We examined two fundamental processes in protein dynamics--protein folding and conformational change within the folded state--by means of extremely long all-atom MD simulations conducted on a special-purpose machine. Equilibrium simulations of a WW protein domain captured multiple folding and unfolding events that consistently follow a well-defined folding pathway; separate simulations of the protein's constituent substructures shed light on possible determinants of this pathway. A 1-millisecond simulation of the folded protein BPTI reveals a small number of structurally distinct conformational states whose reversible interconversion is slower than local relaxations within those states by a factor of more than 1000.

The Dangers of Schooling: The Introduction of School Medical Inspection in the Netherlands (c.1900)

ERIC Educational Resources Information Center

Bakker, Nelleke; de Beer, Fedor

2009-01-01

In this article the authors address the question of why school medical inspection in the Netherlands developed not only considerably slower than the British service but did so also on a more modest scale in terms of the impact on children's lives. In the Netherlands school doctors were not allowed to treat children's illnesses and therefore never…

Spatial-size scaling of pedestrian groups under growing density conditions

NASA Astrophysics Data System (ADS)

Zanlungo, Francesco; Brščić, Dražen; Kanda, Takayuki

2015-06-01

We study the dependence on crowd density of the spatial size, configuration, and velocity of pedestrian social groups. We find that, in the investigated density range, the extension of pedestrian groups in the direction orthogonal to that of motion decreases linearly with the pedestrian density around them, both for two- and three-person groups. Furthermore, we observe that at all densities, three-person groups walk slower than two-person groups, and the latter are slower than individual pedestrians, the differences in velocities being weakly affected by density. Finally, we observe that three-person groups walk in a V-shaped formation regardless of density, with a distance between the pedestrians in the front and back again almost independent of density, although the configuration appears to be less stable at higher densities. These findings may facilitate the development of more realistic crowd dynamics models and simulators.

T-34C back seat instrument panel

NASA Image and Video Library

1997-05-15

The back seat instrument panel on the NASA T-34C chase plane. In its role as a military trainer, the instructor pilot would ride in the back seat, while the student would be in the front seat. As a chase plane, the back seat would be occupied by a photographer. The aircraft was previously used at the Lewis Research Center in propulsion experiments involving turboprop engines, and was used as a chase aircraft at Dryden for smaller and slower research projects. Chase aircraft accompany research flights for photography and video purposes, and also as support for safety and research. At Dryden, the T-34 is used mainly for smaller remotely piloted vehicles which fly slower than NASA's F-18's, used for larger scale projects. This aircraft was returned to the U.S. Navy in May of 2002. The T-34C, built by Beech, carries a crew of 2 and is nicknamed the Mentor.

Time and Performance on the California Critical Thinking Skills Test.

ERIC Educational Resources Information Center

Frisby, Craig L.; Traffanstedt, Bobby K.

2003-01-01

Investigates the relationship between total scores on the California Critical Thinking Skills Test (CCTST) and the time taken to complete it. Finds that slower test takers obtained significantly higher scores. Discusses implications of these findings for college instruction. (SG)

Internalizing versus Externalizing Control: Different Ways to Perform a Time-Based Prospective Memory Task

ERIC Educational Resources Information Center

Huang, Tracy; Loft, Shayne; Humphreys, Michael S.

2014-01-01

"Time-based prospective memory" (PM) refers to performing intended actions at a future time. Participants with time-based PM tasks can be slower to perform ongoing tasks (costs) than participants without PM tasks because internal control is required to maintain the PM intention or to make prospective-timing estimates. However, external…

Aspects of Motor Performance and Preacademic Learning.

ERIC Educational Resources Information Center

Feder, Katya; Kerr, Robert

1996-01-01

The Miller Assessment for Preschoolers (MAP) and a number/counting test were given to 50 4- and 5-year-olds. Low performance on counting was related to significantly slower average response time, overshoot movement time, and reaction time, indicating perceptual-motor difficulty. Low MAP scores indicated difficulty processing visual spatial…

Auditory perceptual simulation: Simulating speech rates or accents?

PubMed

Zhou, Peiyun; Christianson, Kiel

2016-07-01

When readers engage in Auditory Perceptual Simulation (APS) during silent reading, they mentally simulate characteristics of voices attributed to a particular speaker or a character depicted in the text. Previous research found that auditory perceptual simulation of a faster native English speaker during silent reading led to shorter reading times that auditory perceptual simulation of a slower non-native English speaker. Yet, it was uncertain whether this difference was triggered by the different speech rates of the speakers, or by the difficulty of simulating an unfamiliar accent. The current study investigates this question by comparing faster Indian-English speech and slower American-English speech in the auditory perceptual simulation paradigm. Analyses of reading times of individual words and the full sentence reveal that the auditory perceptual simulation effect again modulated reading rate, and auditory perceptual simulation of the faster Indian-English speech led to faster reading rates compared to auditory perceptual simulation of the slower American-English speech. The comparison between this experiment and the data from Zhou and Christianson (2016) demonstrate further that the "speakers'" speech rates, rather than the difficulty of simulating a non-native accent, is the primary mechanism underlying auditory perceptual simulation effects. Copyright © 2016 Elsevier B.V. All rights reserved.

Nearest-Neighbor Distances and Aggregative Effects in Turbulence

NASA Astrophysics Data System (ADS)

Lanerolle, Lyon W. J.; Rothschild, B. J.; Yeung, P. K.

2000-11-01

The dispersive nature of turbulence which causes fluid elements to move apart (on average) is well known. Here we study another facet of turbulent mixing relevant to marine population dynamics - on how small organisms (approximated by fluid particles) are brought close to each other and allowed to interact. The crucial role played by the small scales in this process allows us to use direct numerical simulations of stationary isotropic turbulence, here with Taylor-scale Reynolds numbers (R_λ) from 38 to 91. We study the evolution of the Nearest-Neighbor Distances (NND) for collections of fluid particles initially located randomly in space satisfying Poisson-type distributions with mean values from 0.5 to 2.0 Kolmogorov length scales. Our results show that as particles begin to disperse on average, some also begin to aggregate in space. In particular, we find that (i) a significant proportion of particles are closer to each other than if their NNDs were randomly distributed, (ii) aggregative effects become stronger with R_λ, and (iii) although the mean value of NND grows monotonically with time in Kolmogorov variables, the growth rates are slower at higher R_λ. These results may assist in explaining the ``patchiness'' in plankton distributions observed in biological oceanography. Further details are given in B. J. Rothschild et al., The Biophysical Interpretation of Spatial Effects of Small-scale Turbulent Flow in the Ocean (paper in prep.).

Age-Related Imbalance Is Associated With Slower Walking Speed: An Analysis From the National Health and Nutrition Examination Survey.

PubMed

Xie, Yanjun J; Liu, Elizabeth Y; Anson, Eric R; Agrawal, Yuri

Walking speed is an important dimension of gait function and is known to decline with age. Gait function is a process of dynamic balance and motor control that relies on multiple sensory inputs (eg, visual, proprioceptive, and vestibular) and motor outputs. These sensory and motor physiologic systems also play a role in static postural control, which has been shown to decline with age. In this study, we evaluated whether imbalance that occurs as part of healthy aging is associated with slower walking speed in a nationally representative sample of older adults. We performed a cross-sectional analysis of the previously collected 1999 to 2002 National Health and Nutrition Examination Survey (NHANES) data to evaluate whether age-related imbalance is associated with slower walking speed in older adults aged 50 to 85 years (n = 2116). Balance was assessed on a pass/fail basis during a challenging postural task-condition 4 of the modified Romberg Test-and walking speed was determined using a 20-ft (6.10 m) timed walk. Multivariable linear regression was used to evaluate the association between imbalance and walking speed, adjusting for demographic and health-related covariates. A structural equation model was developed to estimate the extent to which imbalance mediates the association between age and slower walking speed. In the unadjusted regression model, inability to perform the NHANES balance task was significantly associated with 0.10 m/s slower walking speed (95% confidence interval: -0.13 to -0.07; P < .01). In the multivariable regression analysis, inability to perform the balance task was significantly associated with 0.06 m/s slower walking speed (95% confidence interval: -0.09 to -0.03; P < .01), an effect size equivalent to 12 years of age. The structural equation model estimated that age-related imbalance mediates 12.2% of the association between age and slower walking speed in older adults. In a nationally representative sample, age-related balance limitation was associated with slower walking speed. Balance impairment may lead to walking speed declines. In addition, reduced static postural control and dynamic walking speed that occur with aging may share common etiologic origins, including the decline in visual, proprioceptive, and vestibular sensory and motor functions.

Parallel spatial direct numerical simulations on the Intel iPSC/860 hypercube

NASA Technical Reports Server (NTRS)

Joslin, Ronald D.; Zubair, Mohammad

1993-01-01

The implementation and performance of a parallel spatial direct numerical simulation (PSDNS) approach on the Intel iPSC/860 hypercube is documented. The direct numerical simulation approach is used to compute spatially evolving disturbances associated with the laminar-to-turbulent transition in boundary-layer flows. The feasibility of using the PSDNS on the hypercube to perform transition studies is examined. The results indicate that the direct numerical simulation approach can effectively be parallelized on a distributed-memory parallel machine. By increasing the number of processors nearly ideal linear speedups are achieved with nonoptimized routines; slower than linear speedups are achieved with optimized (machine dependent library) routines. This slower than linear speedup results because the Fast Fourier Transform (FFT) routine dominates the computational cost and because the routine indicates less than ideal speedups. However with the machine-dependent routines the total computational cost decreases by a factor of 4 to 5 compared with standard FORTRAN routines. The computational cost increases linearly with spanwise wall-normal and streamwise grid refinements. The hypercube with 32 processors was estimated to require approximately twice the amount of Cray supercomputer single processor time to complete a comparable simulation; however it is estimated that a subgrid-scale model which reduces the required number of grid points and becomes a large-eddy simulation (PSLES) would reduce the computational cost and memory requirements by a factor of 10 over the PSDNS. This PSLES implementation would enable transition simulations on the hypercube at a reasonable computational cost.

Linkages between terrestrial ecosystems and the atmosphere

NASA Technical Reports Server (NTRS)

Bretherton, Francis; Dickinson, Robert E.; Fung, Inez; Moore, Berrien, III; Prather, Michael; Running, Steven W.; Tiessen, Holm

1992-01-01

The primary research issue in understanding the role of terrestrial ecosystems in global change is analyzing the coupling between processes with vastly differing rates of change, from photosynthesis to community change. Representing this coupling in models is the central challenge to modeling the terrestrial biosphere as part of the earth system. Terrestrial ecosystems participate in climate and in the biogeochemical cycles on several temporal scales. Some of the carbon fixed by photosynthesis is incorporated into plant tissue and is delayed from returning to the atmosphere until it is oxidized by decomposition or fire. This slower (i.e., days to months) carbon loop through the terrestrial component of the carbon cycle, which is matched by cycles of nutrients required by plants and decomposers, affects the increasing trend in atmospheric CO2 concentration and imposes a seasonal cycle on that trend. Moreover, this cycle includes key controls over biogenic trace gas production. The structure of terrestrial ecosystems, which responds on even longer time scales (annual to century), is the integrated response to the biogeochemical and environmental constraints that develop over the intermediate time scale. The loop is closed back to the climate system since it is the structure of ecosystems, including species composition, that sets the terrestrial boundary condition in the climate system through modification of surface roughness, albedo, and, to a great extent, latent heat exchange. These separate temporal scales contain explicit feedback loops which may modify ecosystem dynamics and linkages between ecosystems and the atmosphere. The long-term change in climate, resulting from increased atmospheric concentrations of greenhouse gases (e.g., CO2, CH4, and nitrous oxide (N2O)) will further modify the global environment and potentially induce further ecosystem change. Modeling these interactions requires coupling successional models to biogeochemical models to physiological models that describe the exchange of water, energy, and biogenic trace gases between the vegetation and the atmosphere at fine time scales. There does not appear to be any obvious way to allow direct reciprocal coupling of atmospheric general circulation models (GCM's), which inherently run with fine time steps, to ecosystem or successional models, which have coarse temporal resolution, without the interposition of physiological canopy models. This is equally true for biogeochemical models of the exchange of carbon dioxide and trace gases. This coupling across time scales is nontrivial and sets the focus for the modeling strategy.

Trajectories of positive, negative and general psychopathology symptoms in first episode psychosis and their relationship with functioning over a 2-year follow-up period.

PubMed

Abdin, Edimansyah; Chong, Siow Ann; Vaingankar, Janhavi Ajit; Peh, Chao Xu; Poon, Lye Yin; Rao, Sujatha; Verma, Swapna; Subramaniam, Mythily

2017-01-01

Few studies have examined the trajectories of symptom severity in first episode psychosis (FEP) and their impact on functioning. This study aimed to identify discrete trajectories of positive, negative and general psychopathological symptoms and functioning, determine predictors of the identified symptom trajectories and subsequently investigate the relationship between symptom and functioning trajectories over the 2-year follow-up period. Data were extracted from the Singapore Early Psychosis Intervention Programme clinical database. Trajectories of the Positive and Negative Syndrome Scale and Global Assessment of Functioning (GAF) scale over the two-year follow up were modelled using latent class growth curve modelling. Two distinct trajectories (early response and stable trajectory and delayed response trajectory) for positive symptoms, four distinct trajectories (early response and stable trajectory, early response and relapse trajectory, slower response and no response trajectory and delayed response trajectory) for negative and general psychopathology symptoms and three distinct trajectories for functioning (high functioning trajectory, moderately stable functioning trajectory and deterioration in functioning trajectory) were identified in our sample. Compared to individuals in the early response and stable trajectory, those in the delayed response trajectory for positive and negative symptoms, early response and relapse for negative and general psychopathology symptoms and slower response and no response trajectories for general psychopathology symptoms were significantly associated with higher odds of having deterioration in functioning over time. Poor symptom trajectories were also significantly predicted by younger age, male gender, unemployed and economically inactive status, lower education, longer duration of untreated psychosis and diagnosis of schizophrenia spectrum and delusional disorders. The results confirm that the symptoms trajectories among patients with FEP are heterogeneous and suggest that a small group of patients may be at higher risk of deterioration in symptom severity and functioning over the 2-year follow-up.

Time for a strategy in night-time dopaminergic therapy? An objective sensor-based analysis of nocturnal hypokinesia and sleeping positions in Parkinson's disease.

PubMed

Sringean, Jirada; Anan, Chanawat; Thanawattano, Chusak; Bhidayasiri, Roongroj

2017-02-15

Nocturnal hypokinesia is a common night-time symptom in patients with Parkinson's disease (PD). However, there is still little understanding of the nature, and variations of severity of this symptom. To evaluate the severity of nocturnal hypokinesia and sleep positions in PD patients using multisite wearable sensors. Nocturnal parameters and sleep positions in 18 PD couples were assessed and compared using wearable sensors (limbs and trunk) for one night in their homes. Nocturnal parameters included number, velocity, acceleration, degree, limb movements and the number of times they got out of bed. PD patients had significantly fewer episodes of turns in bed than their spouses (p=0.043), which was associated with significantly slower speed (p=0.005), acceleration (p=0.005) and fewer degrees (p=0.017). When we split the night into the first and second half, significant findings were mainly demonstrated in the second half of the night, including significantly fewer turns (p=0.02) with smaller degrees (p=0.017), slower speed (p=0.005) and acceleration (p=0.007). No significant differences in these parameters were shown in the first half of the night except for smaller degrees of turn in bed in PD patients (p=0.028) and slower acceleration (p=0.037). In addition, PD patients spent significantly more time in a supine position compared to their spouses (p=0.031) with significantly less time in a prone position (p=0.041). Nocturnal hypokinesia gets worse as the night progresses. Treatment of nocturnal hypokinesia should aim at providing a continuous dopaminergic delivery that can achieve a sustained therapeutic level of dopamine throughout the night. Copyright © 2016 Elsevier B.V. All rights reserved.

The Slow Developmental Time Course of Real-Time Spoken Word Recognition

ERIC Educational Resources Information Center

Rigler, Hannah; Farris-Trimble, Ashley; Greiner, Lea; Walker, Jessica; Tomblin, J. Bruce; McMurray, Bob

2015-01-01

This study investigated the developmental time course of spoken word recognition in older children using eye tracking to assess how the real-time processing dynamics of word recognition change over development. We found that 9-year-olds were slower to activate the target words and showed more early competition from competitor words than…

Collagen insulated from tensile damage by domains that unfold reversibly: in situ X-ray investigation of mechanical yield and damage repair in the mussel byssus

PubMed Central

Harrington, Matthew J.; Gupta, Himadri S.; Fratzl, Peter; Waite, J. Herbert

2009-01-01

The byssal threads of the California mussel, Mytilus californianus, are highly hysteretic, elastomeric fibers that collectively perform a holdfast function in wave-swept rocky seashore habitats. Following cyclic loading past the mechanical yield point, threads exhibit a damage-dependent reduction in mechanical performance. However, the distal portion of the byssal thread is capable of recovering initial material properties through a time-dependent healing process in the absence of active cellular metabolism. Byssal threads are composed almost exclusively of multi-domain hybrid collagens known as preCols, which largely determine the mechanical properties of the thread. Here, the structure-property relationships that govern thread mechanical performance are further probed. The molecular rearrangements that occur during yield and damage repair were investigated using time-resolved in situ wide angle X-ray diffraction (WAXD) coupled with cyclic tensile loading of threads and through thermally enhanced damage-repair studies. Results indicate that the collagen domains in byssal preCols are mechanically protected by the unfolding of sacrificial non-collagenous domains that refold on a slower time-scale. Time-dependent healing is primarily attributed to stochastic recoupling of broken histidine-metal coordination complexes. PMID:19275941

High-Precision Tests of Stochastic Thermodynamics in a Feedback Trap

NASA Astrophysics Data System (ADS)

Gavrilov, Momčilo; Jun, Yonggun; Bechhoefer, John

2015-03-01

Feedback traps can trap and manipulate small particles and molecules in solution. They have been applied to the measurement of physical and chemical properties of particles and to explore fundamental questions in the non-equilibrium statistical mechanics of small systems. Feedback traps allow one to choose an arbitrary virtual potential, do any time-dependent transformation of the potential, and measure various thermodynamic quantities such as stochastic work, heat, or entropy. In feedback-trap experiments, the dynamics of a trapped object is determined by the imposed potential but is also affected by drifts due to electrochemical reactions and by temperature variations in the electronic amplifier. Although such drifts are small for measurements on the order of seconds, they dominate on time scales of minutes or slower. In this talk, we present a recursive algorithm that allows real-time estimations of drifts and other particle properties. These estimates let us do a real-time calibration of the feedback trap. Having eliminated systematic errors, we were able to show that erasing a one-bit memory requires at least kT ln 2 of work, in accordance with Landauer's principle. This work was supported by NSERC (Canada).

Emotional attentional control predicts changes in diurnal cortisol secretion following exposure to a prolonged psychosocial stressor.

PubMed

Lenaert, Bert; Barry, Tom J; Schruers, Koen; Vervliet, Bram; Hermans, Dirk

2016-01-01

Hypothalamic-pituitary-adrenal (HPA) axis irregularities have been associated with several psychological disorders. Hence, the identification of individual difference variables that predict variations in HPA-axis activity represents an important challenge for psychiatric research. We investigated whether self-reported attentional control in emotionally demanding situations prospectively predicted changes in diurnal salivary cortisol secretion following exposure to a prolonged psychosocial stressor. Low ability to voluntarily control attention has previously been associated with anxiety and depressive symptomatology. Attentional control was assessed using the Emotional Attentional Control Scale. In students who were preparing for academic examination, salivary cortisol was assessed before (time 1) and after (time 2) examination. Results showed that lower levels of self-reported emotional attentional control at time 1 (N=90) predicted higher absolute diurnal cortisol secretion and a slower decline in cortisol throughout the day at time 2 (N=71). Difficulty controlling attention during emotional experiences may lead to chronic HPA-axis hyperactivity after prolonged exposure to stress. These results indicate that screening for individual differences may foster prediction of HPA-axis disturbances, paving the way for targeted disorder prevention. Copyright © 2015 Elsevier Ltd. All rights reserved.

Solving large scale structure in ten easy steps with COLA

NASA Astrophysics Data System (ADS)

Tassev, Svetlin; Zaldarriaga, Matias; Eisenstein, Daniel J.

2013-06-01

We present the COmoving Lagrangian Acceleration (COLA) method: an N-body method for solving for Large Scale Structure (LSS) in a frame that is comoving with observers following trajectories calculated in Lagrangian Perturbation Theory (LPT). Unlike standard N-body methods, the COLA method can straightforwardly trade accuracy at small-scales in order to gain computational speed without sacrificing accuracy at large scales. This is especially useful for cheaply generating large ensembles of accurate mock halo catalogs required to study galaxy clustering and weak lensing, as those catalogs are essential for performing detailed error analysis for ongoing and future surveys of LSS. As an illustration, we ran a COLA-based N-body code on a box of size 100 Mpc/h with particles of mass ≈ 5 × 109Msolar/h. Running the code with only 10 timesteps was sufficient to obtain an accurate description of halo statistics down to halo masses of at least 1011Msolar/h. This is only at a modest speed penalty when compared to mocks obtained with LPT. A standard detailed N-body run is orders of magnitude slower than our COLA-based code. The speed-up we obtain with COLA is due to the fact that we calculate the large-scale dynamics exactly using LPT, while letting the N-body code solve for the small scales, without requiring it to capture exactly the internal dynamics of halos. Achieving a similar level of accuracy in halo statistics without the COLA method requires at least 3 times more timesteps than when COLA is employed.

Reaction time, impulsivity, and attention in hyperactive children and controls: a video game technique.

PubMed

Mitchell, W G; Chavez, J M; Baker, S A; Guzman, B L; Azen, S P

1990-07-01

Maturation of sustained attention was studied in a group of 52 hyperactive elementary school children and 152 controls using a microcomputer-based test formatted to resemble a video game. In nonhyperactive children, both simple and complex reaction time decreased with age, as did variability of response time. Omission errors were extremely infrequent on simple reaction time and decreased with age on the more complex tasks. Commission errors had an inconsistent relationship with age. Hyperactive children were slower, more variable, and made more errors on all segments of the game than did controls. Both motor speed and calculated mental speed were slower in hyperactive children, with greater discrepancy for responses directed to the nondominant hand, suggesting that a selective right hemisphere deficit may be present in hyperactives. A summary score (number of individual game scores above the 95th percentile) of 4 or more detected 60% of hyperactive subjects with a false positive rate of 5%. Agreement with the Matching Familiar Figures Test was 75% in the hyperactive group.

New insights into the interface between a single-crystalline metal electrode and an extremely pure ionic liquid: slow interfacial processes and the influence of temperature on interfacial dynamics.

PubMed

Drüschler, Marcel; Borisenko, Natalia; Wallauer, Jens; Winter, Christian; Huber, Benedikt; Endres, Frank; Roling, Bernhard

2012-04-21

Ionic liquids are of high interest for the development of safe electrolytes in modern electrochemical cells, such as batteries, supercapacitors and dye-sensitised solar cells. However, electrochemical applications of ionic liquids are still hindered by the limited understanding of the interface between electrode materials and ionic liquids. In this article, we first review the state of the art in both experiment and theory. Then we illustrate some general trends by taking the interface between the extremely pure ionic liquid 1-butyl-1-methylpyrrolidinium tris(pentafluoroethyl)trifluorophosphate and an Au(111) electrode as an example. For the study of this interface, electrochemical impedance spectroscopy was combined with in situ STM and in situ AFM techniques. In addition, we present new results for the temperature dependence of the interfacial capacitance and dynamics. Since the interfacial dynamics are characterised by different processes taking place on different time scales, the temperature dependence of the dynamics can only be reliably studied by recording and carefully analysing broadband capacitance spectra. Single-frequency experiments may lead to artefacts in the temperature dependence of the interfacial capacitance. We demonstrate that the fast capacitive process exhibits a Vogel-Fulcher-Tamman temperature dependence, since its time scale is governed by the ionic conductivity of the ionic liquid. In contrast, the slower capacitive process appears to be Arrhenius activated. This suggests that the time scale of this process is determined by a temperature-independent barrier, which may be related to structural reorganisations of the Au surface and/or to charge redistributions in the strongly bound innermost ion layer. This journal is © the Owner Societies 2012

Evaluation of the in vivo disintegration of solid dosage forms of a bile acid sequestrant in dogs using gamma-scintigraphy and correlation to in vitro disintegration.

PubMed

Hussain, Munir A; Chang, Rong-Kun; Sandefer, Erik; Page, Richard C; Digenis, George A

2003-03-01

[corrected] To evaluate the in vivo disintegration behavior of tablets and capsules of a bile acid sequestrant, DMP 504, in beagle dogs and to assess the significance of the in vitro disintegration of the dosage forms on subsequent in vivo behavior in order to draw possible in vitro-in vivo correlations. Tablet and capsule formulations of a bile acid sequestrant, DMP 504, were formulated with samarium oxide and neutron activated to produce radioactive 53Sm to noninvasively evaluate their in vivo behavior in beagle dogs by gamma-scintigraphy. A four-way crossover design was completed (n = 4) in which (a) tablets from two different batches were administered under the fasted condition and manufactured using different lots of drug substance where one batch exhibited relatively faster in vitro disintegration time (30 min) than the other tablet batch, which resulted in slower disintegration (45 min), (b) a capsule formulation was administered to fasted beagles, and (c) the tablet having slower in vitro disintegration was also administered in the fed state, and its in vivo disintegration was compared to that observed in the fasted state. Tablets manufactured using a lot of DMP 504 having relatively fast in vitro disintegration (approximately 30 min) resulted in relatively rapid in vivo disintegration time (15 min) in the fasted condition. This in vivo disintegration time was comparable to the in vivo disintegration of the capsules (17 min) even though the in vitro capsule disintegration time was considerably faster (2 min). Tablets prepared using a drug substance that provided a longer in vitro disintegration time (approximately 45 min) resulted in a slower in vivo disintegration (63 min). There was no difference observed in the in vivo disintegration behavior in fasted and fed dogs for the tablets that provided slower in vitro disintegration. In vivo disintegration of tablets of the bile acid sequestrant DMP 504 correlated with in vitro disintegration times. Gamma-Scintigraphy continues to be a good tool to use during early stages of product development to investigate in vivo performance of dosage forms. The results of this study provided evidence that the physical chemical specifications of the drug substance may not always be indicative of in vitro or in vivo performance of tablet dosage form, even when formulation and process are not changed.

Neuromuscular performance in the hip joint of elderly fallers and non-fallers.

PubMed

Morcelli, Mary Hellen; LaRoche, Dain Patrick; Crozara, Luciano Fernandes; Marques, Nise Ribeiro; Hallal, Camilla Zamfolini; Rossi, Denise Martineli; Gonçalves, Mauro; Navega, Marcelo Tavella

2016-06-01

Low strength and neuromuscular activation of the lower limbs have been associated with falls making it an important predictor of functional status in the elderly. To compare the rate of neuromuscular activation, rate of torque development, peak torque and reaction time between young and elderly fallers and non-fallers for hip flexion and extension. We evaluated 44 elderly people who were divided into two groups: elderly fallers (n = 20) and elderly non-fallers (n = 24); and 18 young people. The subjects performed three isometric hip flexion and extension contractions. Electromyography data were collected for the rectus femoris, gluteus maximus and biceps femoris muscles. The elderly had 49 % lower peak torque and 68 % lower rate of torque development for hip extension, 28 % lower rate of neuromuscular activation for gluteus maximus and 38 % lower rate of neuromuscular activation for biceps femoris than the young (p < 0.05). Furthermore, the elderly had 42 % lower peak torque and 62 % lower rate of torque development for hip flexion and 48 % lower rate of neuromuscular for rectus femoris than the young (p < 0.05). The elderly fallers showed consistent trend toward a lower rate of torque development than elderly non-fallers for hip extension at 50 ms (29 %, p = 0.298, d = 0.76) and 100 ms (26 %, p = 0.452, d = 0.68).The motor time was 30 % slower for gluteus maximus, 42 % slower for rectus femoris and 50 % slower for biceps femoris in the elderly than in the young. Impaired capacity of the elderly, especially fallers, may be explained by neural and morphological aspects of the muscles. The process of senescence affects the muscle function of the hip flexion and extension, and falls may be related to lower rate of torque development and slower motor time of biceps femoris.

Travelers' Health: Pregnant Travelers

MedlinePlus

... Most experts recommend a slower ascent with adequate time for acclimatization. No studies or case reports show harm to a fetus if the mother travels briefly to high altitudes during pregnancy. However, it ...

Gait Parameter Adjustments for Walking on a Treadmill at Preferred, Slower, and Faster Speeds in Older Adults with Down Syndrome

PubMed Central

Smith, Beth A.; Kubo, Masayoshi; Ulrich, Beverly D.

2012-01-01

The combined effects of ligamentous laxity, hypotonia, and decrements associated with aging lead to stability-enhancing foot placement adaptations during routine overground walking at a younger age in adults with Down syndrome (DS) compared to their peers with typical development (TD). Our purpose here was to examine real-time adaptations in older adults with DS by testing their responses to walking on a treadmill at their preferred speed and at speeds slower and faster than preferred. We found that older adults with DS were able to adapt their gait to slower and faster than preferred treadmill speeds; however, they maintained their stability-enhancing foot placements at all speeds compared to their peers with TD. All adults adapted their gait patterns similarly in response to faster and slower than preferred treadmill-walking speeds. They increased stride frequency and stride length, maintained step width, and decreased percent stance as treadmill speed increased. Older adults with DS, however, adjusted their stride frequencies significantly less than their peers with TD. Our results show that older adults with DS have the capacity to adapt their gait parameters in response to different walking speeds while also supporting the need for intervention to increase gait stability. PMID:22693497

An Explanation of the Missing Flux from Boyajian's Mysterious Star

NASA Astrophysics Data System (ADS)

Foukal, Peter

2017-06-01

A previously unremarkable star in the constellation Cygnus has, in the past year, become known as the most mysterious object in our Galaxy. Boyajian’s star exhibits puzzling episodes of sporadic, deep dimming discovered in photometry with the Kepler Mission. Proposed explanations have focused on its obscuration by colliding exoplanets, exocomets, and even intervention of alien intelligence. These hypotheses have considered only phenomena external to the star because the radiative flux missing in the dimmings was believed to exceed the star’s storage capacity. We point out that modeling of variations in solar luminosity indicates that convective stars can store the required fluxes. It also suggests explanations for (a) a reported time-profile asymmetry of the short, deep dimmings and (b) a slower, decadal scale dimming reported from archival and Kepler photometry. Our findings suggest a broader range of explanations of Boyajian’s star that may produce new insights into stellar magneto-convection.

Overshooting thunderheads observed from ATS and Learjet

NASA Technical Reports Server (NTRS)

Fujita, T. T.

1974-01-01

Overshooting tops of thunderstorms were photographed simultaneously from both ATS and a Learjet during the cloud-truth experiment over the Midwest in the Spring of 1972 and 1973. The characteristics of overshooting tops were studied in various time and space scales, revealing that the horizontal dimensions of overshooting tops vary between 1000 ft and about 10 miles. The period of overshooting turrets with horizontal dimensions of less than 1 mile is found to be comparable to the Brunt-Vaisalla frequency of gravity waves at the lowermost stratosphere. The up-and-down motion of an overshooting dome, consisting of a number of turrets, is much slower than that of individual turrets. It is assumed that the height of a dome is closely related to the intensity of the up and downdrafts beneath the dome. Emphasis is placed upon the importance of the investigation of overshooting domes toward the identification of severe storm characteristics from satellites.

Hierarchic spatio-temporal dynamics in glycolysis

NASA Astrophysics Data System (ADS)

Shinjyo, Takahiro; Nakagawa, Yoshiyuki; Ueda, Tetsuo

Yeast extracts exhibit oscillations when the glycolytic system is far away from equilibrium. Spatio-temporal dynamics in this system was studied in the newly developed gel as well as in the solution. Small regions (about 10 um) with very complex shape with high or low concentrations of NADH appeared, and upon these small structures large-scale dynamics were superimposed. Concentration waves propagated, and the source of wave was induced by contact with high ADP. Sink of waves was generated by contacting the reaction gel to two small gels rich in ADP. Upon these spatio-temporal dynamics were superimposed much slower global oscillations throughout the system with a period of about 40 min. Similar dynamics was seen in a solution of yeast extract, but the size of domains was about ten times larger than that in the gel. In this way, the multi-enzyme system of glycolysis exhibits self-organization of hierarchy in spatio-temporal dynamics.

Nitrate removal rates change over time during tracer tests: towards zone specific reaction rates and watershed budgets.

NASA Astrophysics Data System (ADS)

Aubeneau, A. F.; Ghassani, A. F.; Avilar, C.; Xiong, X.; Wang, S.

2016-12-01

Fertilizer pollution leading to downstream eutrofication and hypoxia is a grand challenge affecting aquatic ecosystems and human activities. Here, we present numerical and experimental results showing that simple tracer tests can provide sufficient data to disentangle the contribution of the water column, the benthic zone and the hyporheic zone to total nitrate uptake at the reach scale. The processes that drive nitrate removal are very different in these three distinct environments and their relative contribution change along the river continuum. The dark, often hypoxic hyporheic zone is where denitrification takes place, while autotrophs temporarily store nitrogen in their biomass in the benthos or the water column. The contribution of pelagic uptake increases downstream as rivers are deeper and slower. Together, these findings can be gathered to empirically inform watershed models and arrive at better nutrient budgets and water quality predictions.

Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape?

NASA Astrophysics Data System (ADS)

Drobinski, P.; Alonzo, B.; Bastin, S.; Silva, N. Da; Muller, C.

2016-04-01

Expected changes to future extreme precipitation remain a key uncertainty associated with anthropogenic climate change. Extreme precipitation has been proposed to scale with the precipitable water content in the atmosphere. Assuming constant relative humidity, this implies an increase of precipitation extremes at a rate of about 7% °C-1 globally as indicated by the Clausius-Clapeyron relationship. Increases faster and slower than Clausius-Clapeyron have also been reported. In this work, we examine the scaling between precipitation extremes and temperature in the present climate using simulations and measurements from surface weather stations collected in the frame of the HyMeX and MED-CORDEX programs in Southern France. Of particular interest are departures from the Clausius-Clapeyron thermodynamic expectation, their spatial and temporal distribution, and their origin. Looking at the scaling of precipitation extreme with temperature, two regimes emerge which form a hook shape: one at low temperatures (cooler than around 15°C) with rates of increase close to the Clausius-Clapeyron rate and one at high temperatures (warmer than about 15°C) with sub-Clausius-Clapeyron rates and most often negative rates. On average, the region of focus does not seem to exhibit super Clausius-Clapeyron behavior except at some stations, in contrast to earlier studies. Many factors can contribute to departure from Clausius-Clapeyron scaling: time and spatial averaging, choice of scaling temperature (surface versus condensation level), and precipitation efficiency and vertical velocity in updrafts that are not necessarily constant with temperature. But most importantly, the dynamical contribution of orography to precipitation in the fall over this area during the so-called "Cevenoles" events, explains the hook shape of the scaling of precipitation extremes.

Hot water, fresh beer, and salt

NASA Astrophysics Data System (ADS)

Crawford, Frank S.

1990-11-01

In the ``hot chocolate effect'' the best musical scales (those with the finest tone quality, largest range, and best tempo) are obtained by adding salt to a glass of hot water supersaturated with air. Good scales can also be obtained by adding salt to a glass of freshly opened beer (supersaturated with CO2) provided you first (a) get rid of much of the excess CO2 so as to produce smaller, hence slower, rising bubbles, and (b) get rid of the head of foam, which damps the standing wave and ruins the tone quality. Finally the old question, ``Do ionizing particles produce bubbles in fresh beer?'' is answered experimentally.

Blocking serotonin but not dopamine reuptake alters neural processing during perceptual decision making.

PubMed

Costa, Vincent D; Kakalios, Laura C; Averbeck, Bruno B

2016-10-01

Dopamine and serotonin have opponent interactions on aspects of impulsivity. Therefore we wanted to test the hypothesis that dopamine and serotonin would have opposing effects on speed-accuracy trade offs in a perceptual decision making task. Unlike other behavioral measures of impulsivity, perceptual decision making allows us to determine whether decreasing premature responses, often interpreted as decreased impulsivity, corresponds to increased behavioral performance. We administered GBR-12909 (a dopamine transporter blocker), escitalopram (a serotonin transporter blocker), or saline in separate sessions to 3 rhesus macaques. We found that animals had slower reaction times (RTs) on escitalopram than on GBR-12909 or saline. However, they were also least accurate on escitalopram. Animals were faster, although nonsignificantly, on GBR than saline and had equivalent accuracy. Administration of GBR-12909 did cause animals to be faster in error trials than correct trials. Therefore, from the point of view of RTs the animals were less impulsive on escitalopram. However, the decreased accuracy of the monkeys shows that they were not able to make use of their slower response times to make more accurate decisions. Therefore, impulsivity was reduced on escitalopram, but at the expense of a slower information-processing rate in the perceptual inference task. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Adjustment of sleep and the circadian temperature rhythm after flights across nine time zones

NASA Technical Reports Server (NTRS)

Gander, Philippa H.; Myhre, Grete; Graeber, R. Curtis; Lauber, John K.; Andersen, Harald T.

1989-01-01

The adjustment of sleep-wake patterns and the circadian temperature rhythm was monitored in nine Royal Norwegian Airforce volunteers operating P-3 aircraft during a westward training deployment across nine time zones. Subjects recorded all sleep and nap times, rated nightly sleep quality, and completed personality inventories. Rectal temperature, heart rate, and wrist activity were continuously monitored. Adjustment was slower after the return eastward flight than after the outbound westward flight. The eastward flight produced slower readjustment of sleep timing to local time and greater interindividual variability in the patterns of adjustment of sleep and temperature. One subject apparently exhibited resynchronization by partition, with the temperature rhythm undergoing the reciprocal 15-h delay. In contrast, average heart rates during sleep were significantly elevated only after westward flight. Interindividual differences in adjustment of the temperature rhythm were correlated with some of the personality measures. Larger phase delays in the overall temperature waveform (as measured on the 5th day after westward flight) were exhibited by extraverts, and less consistently by evening types.

Longitudinal changes in intellectual development in children with Fragile X syndrome.

PubMed

Hall, Scott S; Burns, David D; Lightbody, Amy A; Reiss, Allan L

2008-08-01

Structural equation modeling (SEM) was used to examine the development of intellectual functioning in 145 school-age pairs of siblings. Each pair included one child with Fragile X syndrome (FXS) and one unaffected sibling. All pairs of children were evaluated on the Wechsler Intelligence Scale for Children-Third Edition (WISC-III) at time 1 and 80 pairs of children received a second evaluation at time 2 approximately 4 years later. Compared to their unaffected siblings, children with FXS obtained significantly lower percentage correct scores on all subtests of the WISC at both time points. During the time between the first and second assessments, the annual rate of intellectual development was approximately 2.2 times faster in the unaffected children compared to the children with FXS. Levels of the fragile X mental retardation protein (FMRP) were highly associated with intellectual ability scores of the children with FXS at both time points (r=0.55 and 0.64 respectively). However, when gender, age, and the time between assessments were included as covariates in the structural equation model, FMRP accounted for only 5% of the variance in intellectual ability scores at time 1 and 13% of the variance at time 2. The results of this study suggest that slower learning contributes to the low and declining standardized IQ scores observed in children with FXS.

The effect of split sleep schedules (6h-on/6h-off) on neurobehavioural performance, sleep and sleepiness.

PubMed

Short, Michelle A; Centofanti, Stephanie; Hilditch, Cassie; Banks, Siobhan; Lushington, Kurt; Dorrian, Jillian

2016-05-01

Shorter, more frequent rosters, such as 6h-on/6h-off split shifts, may offer promise to sleep, subjective sleepiness and performance by limiting shift length and by offering opportunities for all workers to obtain some sleep across the biological night. However, there exists a paucity of studies that have examined these shifts using objective measures of sleep and performance. The present study examined neurobehavioural performance, sleepiness and sleep during 6h-on/6h-off split sleep schedules. Sixteen healthy adults (6 males, 26.13 y ± 4.46) participated in a 9-day laboratory study that included two baseline nights (BL, 10h time in bed (TIB), 2200 h-0800 h), 4 days on one of two types of 6h-on/6h-off split sleep schedules with 5h TIB during each 'off' period (6h early: TIB 0300 h-0800 h and 1500 h-20000 h, or 6-h late: TIB 0900 h-1400 h and 2100 h-0200 h), and two recovery nights (10h TIB per night, 2200 h-0800 h). Participants received 10h TIB per 24h in total across both shift schedules. A neurobehavioural test bout was completed every 2 h during wake, which included the Psychomotor Vigilance Task (PVT) and the Karolinska Sleepiness Scale (KSS). Linear mixed effects models were used to assess the effect of day (BL, shift days 1-4), schedule (6h early, 6h late) and trial (numbers 1-6) on PVT lapses (operationalised as the number of reaction times >500 ms), PVT total lapse time, PVT fastest 10% of reaction times and KSS. Analyses were also conducted examining the effect of day and schedule on sleep variables. Overall, PVT lapses and total lapse time did not differ significantly between baseline and shift days, however, peak response speeds were significantly slower on the first shift day when compared to baseline, but only for those in the 6h-late condition. Circadian variations were apparent in performance outcomes, with individuals in the 6h-late condition demonstrated significantly more and longer lapses and slower peak reaction times at the end of their night shift (0730 h) than at any other time during their shifts. In the 6h-early condition, only response speed significantly differed across trials, with slower response speeds occurring at trial 1 (0930 h) than in trials 3 (1330 h) or 4 (2130 h). While subjective sleepiness was higher on shift days than at baseline, sleepiness did not accumulate across days. Total sleep was reduced across split sleep schedules compared to baseline. Overall, these results show that while there was not a cumulative cost to performance across days of splitting sleep, participants obtained less sleep and reported lowered alertness on shift days. Tests near the circadian nadir showed higher sleepiness and increased performance deficits. While this schedule did not produce cumulative impairment, the performance deficits witnessed during the biological night are still of operational concern for industry and workers alike. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

A Divided Attention Experiment with Pervasively Hyperactive Children.

ERIC Educational Resources Information Center

van der Meere, Jaap; Sergeant, Joseph

1987-01-01

Task performance of 12 pervasive hyperactives and controls (ages 8-13) was studied in a divided attention reaction time experiment. Hyperactives were slower than controls, had more variable reaction times, and made more frequent errors. Task inefficiency in hyperactives could not be explained by a divided attention deficiency or impulsive…

Useful visual field in patients with schizophrenia: a choice reaction time study.

PubMed

Matsuda, Yukihisa; Matsui, Mie; Tonoya, Yasuhiro; Ebihara, Naokuni; Kurachi, Masayoshi

2011-04-01

This study examined the size of the useful visual field in patients (9 men, 6 women) with schizophrenia. A choice reaction task was conducted, and performances at 2.5, 5, 7, 10, and 25 degrees in both visual fields were measured. Three key findings were shown. First, patients had slower choice reaction times (choice RTs) than normal controls. Second, patients had slower choice RTs in the right visual field than in the left visual field. Third, patients and normal controls showed the same U-shaped choice RT pattern. The first and second findings were consistent with those of other studies. The third finding was a clear indication of the patients' performance in peripheral vision, and a comparison with normal controls suggested that there was no difference in the size of the useful visual field, at least within

Modulation of inward rectifier potassium channel by toosendanin, a presynaptic blocker.

PubMed

Wang, Z F; Shi, Y L

2001-07-01

The effect of toosendanin, a presynaptic blocker, on the inward rectifier potassium channel (K(Kir)) of hippocampal CA1 pyramidal neurons of rats was studied by the single-channel patch-clamp technique. The results showed that toosendanin had an inhibitory effect on K(Kir) in an excised inside-out patch of the neuron under a symmetrical 150 mM K(+) condition. By decreasing the slower open time constant and increasing the slower close time constant, toosendanin (1x10(-6)-1x10(-4) g/ml) significantly reduced the open probability of the channel in a concentration-dependent manner. Meanwhile, a dose-dependent reduction in unitary conductance of the channel was also detected after toosendanin application. These data offer an explanation for toosendanin-induced facilitation of neurotransmitter release and antibotulismic effect of the drug.

Slow Versus Fast Robot-Assisted Locomotor Training After Severe Stroke: A Randomized Controlled Trial.

PubMed

Rodrigues, Thais Amanda; Goroso, Daniel Gustavo; Westgate, Philip M; Carrico, Cheryl; Batistella, Linamara R; Sawaki, Lumy

2017-10-01

Robot-assisted locomotor training on a bodyweight-supported treadmill is a rehabilitation intervention that compels repetitive practice of gait movements. Standard treadmill speed may elicit rhythmic movements generated primarily by spinal circuits. Slower-than-standard treadmill speed may elicit discrete movements, which are more complex than rhythmic movements and involve cortical areas. Compare effects of fast (i.e., rhythmic) versus slow (i.e., discrete) robot-assisted locomotor training on a bodyweight-supported treadmill in subjects with chronic, severe gait deficit after stroke. Subjects (N = 18) were randomized to receive 30 sessions (5 d/wk) of either fast or slow robot-assisted locomotor training on a bodyweight-supported treadmill in an inpatient setting. Functional ambulation category, time up and go, 6-min walk test, 10-m walk test, Berg Balance Scale, and Fugl-Meyer Assessment were administered at baseline and postintervention. The slow group had statistically significant improvement on functional ambulation category (first quartile-third quartile, P = 0.004), 6-min walk test (95% confidence interval [CI] = 1.8 to 49.0, P = 0.040), Berg Balance Scale (95% CI = 7.4 to 14.8, P < 0.0001), time up and go (95% CI = -79.1 to 5.0, P < 0.0030), and Fugl-Meyer Assessment (95% CI = 24.1 to 45.1, P < 0.0001). The fast group had statistically significant improvement on Berg Balance Scale (95% CI = 1.5 to 10.5, P = 0.02). In initial stages of robot-assisted locomotor training on a bodyweight-supported treadmill after severe stroke, slow training targeting discrete movement may yield greater benefit than fast training.

Motion detection, novelty filtering, and target tracking using an interferometric technique with GaAs phase conjugate mirror

NASA Technical Reports Server (NTRS)

Cheng, Li-Jen (Inventor); Liu, Tsuen-Hsi (Inventor)

1991-01-01

A method and apparatus for detecting and tracking moving objects in a noise environment cluttered with fast- and slow-moving objects and other time-varying background. A pair of phase conjugate light beams carrying the same spatial information commonly cancel each other out through an image subtraction process in a phase conjugate interferometer, wherein gratings are formed in a fast photorefractive phase conjugate mirror material. In the steady state, there is no output. When the optical path of one of the two phase conjugate beams is suddenly changed, the return beam loses its phase conjugate nature and the interferometer is out of balance, resulting in an observable output. The observable output lasts until the phase conjugate nature of the beam has recovered. The observable time of the output signal is roughly equal to the formation time of the grating. If the optical path changing time is slower than the formation time, the change of optical path becomes unobservable, because the index grating can follow the change. Thus, objects traveling at speeds which result in a path changing time which is slower than the formation time are not observable and do not clutter the output image view.

Assessing Chemical Retention Process Controls in Ponds

NASA Astrophysics Data System (ADS)

Torgersen, T.; Branco, B.; John, B.

2002-05-01

Small ponds are a ubiquitous component of the landscape and have earned a reputation as effective chemical retention devices. The most common characterization of pond chemical retention is the retention coefficient, Ri= ([Ci]inflow-[Ci] outflow)/[Ci]inflow. However, this parameter varies widely in one pond with time and among ponds. We have re-evaluated literature reported (Borden et al., 1998) monthly average retention coefficients for two ponds in North Carolina. Employing a simple first order model that includes water residence time, the first order process responsible for species removal have been separated from the water residence time over which it acts. Assuming the rate constant for species removal is constant within the pond (arguable at least), the annual average rate constant for species removal is generated. Using the annual mean rate constant for species removal and monthly water residence times results in a significantly enhanced predictive capability for Davis Pond during most months of the year. Predictive ability remains poor in Davis Pond during winter/unstratified periods when internal loading of P and N results in low to negative chemical retention. Predictive ability for Piedmont Pond (which has numerous negative chemical retention periods) is improved but not to the same extent as Davis Pond. In Davis Pond, the rate constant for sediment removal (each month) is faster than the rate constant for water and explains the good predictability for sediment retention. However, the removal rate constant for P and N is slower than the removal rate constant for sediment (longer water column residence time for P,N than for sediment). Thus sedimentation is not an overall control on nutrient retention. Additionally, the removal rate constant for P is slower than for TOC (TOC is not the dominate removal process for P) and N is removed slower than P (different in pond controls). For Piedmont Pond, sediment removal rate constants are slower than the removal rate constant for water indicating significant sediment resuspension episodes. It appears that these sediment resuspension events are aperiodic and control the loading and the chemical retention capability of Piedmont Pond for N,P,TOC. These calculated rate constants reflect the differing internal loading processes for each component and suggest means and mechanisms for the use of ponds in water quality management.

Nonexponential Decoherence and Subdiffusion in Atom-Optics Kicked Rotor.

PubMed

Sarkar, Sumit; Paul, Sanku; Vishwakarma, Chetan; Kumar, Sunil; Verma, Gunjan; Sainath, M; Rapol, Umakant D; Santhanam, M S

2017-04-28

Quantum systems lose coherence upon interaction with the environment and tend towards classical states. Quantum coherence is known to exponentially decay in time so that macroscopic quantum superpositions are generally unsustainable. In this work, slower than exponential decay of coherences is experimentally realized in an atom-optics kicked rotor system subjected to nonstationary Lévy noise in the applied kick sequence. The slower coherence decay manifests in the form of quantum subdiffusion that can be controlled through the Lévy exponent. The experimental results are in good agreement with the analytical estimates and numerical simulations for the mean energy growth and momentum profiles of an atom-optics kicked rotor.

Plenum response to simulated disturbances of the model and fan inlet guide vanes in a transonic tunnel

NASA Technical Reports Server (NTRS)

Gloss, B. B.

1980-01-01

In order to aid in the design of the National Transonic Facility (NTF) control system, test section/plenum response studies were carried out in a 0.186 scale model of the NTF high speed duct. Two types of disturbances, those induced by the model and those induced by the compressor inlet guide vanes were simulated. Some observations with regard to the test section/plenum response tests are summarized as follows. A resonance frequency for the test section/plenum area of the tunnel of approximately 50 Hz was observed for Mach numbers from 0.40 to 0.90. However, since the plenum is 3.1 times (based on volume) too large for the scaled size of the test section, care must be taken in extrapolating these data to NTF conditions. The plenum pressure data indicate the existence of pressure gradients in the plenum. The test results indicate that the difference between test section static pressure and plenum pressure is dependent on test section flow conditions. Plenum response to inlet guide vane type disturbances appears to be slower than plenum response to test section disturbances.

Effects of Psychiatric Symptoms on Attention in North Korean Refugees.

PubMed

Lee, Yu Jin; Jun, Jin Yong; Park, Juhyun; Kim, Soohyun; Gwak, Ah Reum; Lee, So Hee; Yoo, So Young; Kim, Seog Ju

2016-09-01

We investigated the performance of North Korean refugees on attention tasks, and the relationship between that performance and psychiatric symptoms. Sustained and divided attention was assessed using the computerized Comprehensive Attention Test in North Korean refugees and in South Koreans. All participants also completed the Beck Depression Inventory, the Beck Anxiety Inventory, the Impact of Event Scale-Revised and the Dissociative Experiences Scale-II (DES-II). The North Korean refugees showed slower reaction times (RTs) on the visual sustained attention task compared to the South Koreans after controlling for age and sex. North Korean refugees had a greater number of omission errors (OEs) on the divided attention task and a higher standard deviation (SD) of RT. Total DES-II scores of the North Korean refugees were associated with the number of OEs and the SD of RT on the sustained attention task, and with the number of OEs on the divided attention task. North Korean refugees showed poorer performance on computerized attention tasks. In addition, attention deficit among North Korean refugees was associated with their dissociative experiences. Our results suggest that refugees may have attention deficits, which may be related to their psychiatric symptoms, particularly dissociation.

Anelastic and Compressible Simulation of Moist Dynamics at Planetary Scales

NASA Astrophysics Data System (ADS)

Kurowski, M.; Smolarkiewicz, P. K.; Grabowski, W.

2015-12-01

Moist anelastic and compressible numerical solutions to the planetary baroclinic instability and climate benchmarks are compared. The solutions are obtained applying a consistent numerical framework for dis- crete integrations of the various nonhydrostatic flow equations. Moist extension of the baroclinic instability benchmark is formulated as an analog of the dry case. Flow patterns, surface vertical vorticity and pressure, total kinetic energy, power spectra, and total amount of condensed water are analyzed. The climate bench- mark extends the baroclinic instability study by addressing long-term statistics of an idealized planetary equilibrium and associated meridional transports. Short-term deterministic anelastic and compressible so- lutions differ significantly. In particular, anelastic baroclinic eddies propagate faster and develop slower owing to, respectively, modified dispersion relation and abbreviated baroclinic vorticity production. These eddies also carry less kinetic energy, and the onset of their rapid growth occurs later than for the compressible solutions. The observed differences between the two solutions are sensitive to initial conditions as they di- minish for large-amplitude excitations of the instability. In particular, on the climatic time scales, the anelastic and compressible solutions evince similar zonally averaged flow patterns with the matching meridional transports of entropy, momentum, and moisture.

Wind-driven circulation patterns in a shallow estuarine lake: St Lucia, South Africa

NASA Astrophysics Data System (ADS)

Schoen, Julia H.; Stretch, Derek D.; Tirok, Katrin

2014-06-01

The spatiotemporal structure of wind-driven circulation patterns and associated water exchanges or residence times can drive important bio-hydrodynamic interactions in shallow lakes and estuaries. The St Lucia estuarine lake in South Africa is an example of such a system. It is a UNESCO World Heritage Site and RAMSAR wetland of international importance but no detailed research on its circulation patterns has previously been undertaken. In this study, a hydrodynamic model was used to investigate the structure of these circulations to provide insights into their role in transport and water exchange processes. A strong diurnal temporal pattern of wind speeds, together with directional switching between two dominant directions, drives intermittent water exchanges and mixing between the lake basins. “High speed flows in shallow nearshore areas with slower upwind counter-flows in deeper areas, linked by circulatory gyres, are key features of the circulation”. These patterns are strongly influenced by the complex geometry of St Lucia and constrictions in the system. Water exchange time scales are non-homogeneous with some basin extremities having relatively long residence times. The influence of the circulation patterns on biological processes is discussed.

Estimating the biophysical properties of neurons with intracellular calcium dynamics.

PubMed

Ye, Jingxin; Rozdeba, Paul J; Morone, Uriel I; Daou, Arij; Abarbanel, Henry D I

2014-06-01

We investigate the dynamics of a conductance-based neuron model coupled to a model of intracellular calcium uptake and release by the endoplasmic reticulum. The intracellular calcium dynamics occur on a time scale that is orders of magnitude slower than voltage spiking behavior. Coupling these mechanisms sets the stage for the appearance of chaotic dynamics, which we observe within certain ranges of model parameter values. We then explore the question of whether one can, using observed voltage data alone, estimate the states and parameters of the voltage plus calcium (V+Ca) dynamics model. We find the answer is negative. Indeed, we show that voltage plus another observed quantity must be known to allow the estimation to be accurate. We show that observing both the voltage time course V(t) and the intracellular Ca time course will permit accurate estimation, and from the estimated model state, accurate prediction after observations are completed. This sets the stage for how one will be able to use a more detailed model of V+Ca dynamics in neuron activity in the analysis of experimental data on individual neurons as well as functional networks in which the nodes (neurons) have these biophysical properties.

Ultrafast electron diffraction study of ab-plane dynamics in superconducting Bi2Sr<2CaCu2O8+d

NASA Astrophysics Data System (ADS)

Konstantinova, Tatiana; Reid, Alexander; Wu, Lijun; Durr, Hermann; Wang, Xijie; Zhu, Yimei

The role of phonons and other collective modes in cooperative electron phenomena in high-TC cuprate superconductors is an extensively interesting topic. Time-resolved experiments provide temporal hierarchy of the bosonic modes interacting with electrons. However, majority of research in this field explore dynamics of electronic states and can only make indirect conclusion about involvement of the lattice. We report time-resolved study of optimally doped Bi2Sr2CaCu2O8+d lattice response to photo-excitation by means of ultrafast electron diffraction that is directly sensitive to atomic motion. Data analysis utilizing Bloch-wave calculation of diffraction peak intensity allows separation of Cu-O in-plane vibration building up on the sub picosecond time scale from the low energy phonon population growth with a much slower rate. This study confirms the assumption of strong electron coupling to the Cu-O plane phonons. This work was supported by the US DOE, Office of Science, Basic Energy Science, Materials Science and Engineering Division under Contract No: DE-AC02-98CH10886; DOE LDRD funding under contract DE-AC02-76SF00515 and BNL.

Estimating the biophysical properties of neurons with intracellular calcium dynamics

NASA Astrophysics Data System (ADS)

Ye, Jingxin; Rozdeba, Paul J.; Morone, Uriel I.; Daou, Arij; Abarbanel, Henry D. I.

2014-06-01

We investigate the dynamics of a conductance-based neuron model coupled to a model of intracellular calcium uptake and release by the endoplasmic reticulum. The intracellular calcium dynamics occur on a time scale that is orders of magnitude slower than voltage spiking behavior. Coupling these mechanisms sets the stage for the appearance of chaotic dynamics, which we observe within certain ranges of model parameter values. We then explore the question of whether one can, using observed voltage data alone, estimate the states and parameters of the voltage plus calcium (V+Ca) dynamics model. We find the answer is negative. Indeed, we show that voltage plus another observed quantity must be known to allow the estimation to be accurate. We show that observing both the voltage time course V (t) and the intracellular Ca time course will permit accurate estimation, and from the estimated model state, accurate prediction after observations are completed. This sets the stage for how one will be able to use a more detailed model of V+Ca dynamics in neuron activity in the analysis of experimental data on individual neurons as well as functional networks in which the nodes (neurons) have these biophysical properties.

Executive functioning complaints and escitalopram treatment response in late-life depression.

PubMed

Manning, Kevin J; Alexopoulos, George S; Banerjee, Samprit; Morimoto, Sarah Shizuko; Seirup, Joanna K; Klimstra, Sibel A; Yuen, Genevieve; Kanellopoulos, Theodora; Gunning-Dixon, Faith

2015-05-01

Executive dysfunction may play a key role in the pathophysiology of late-life depression. Executive dysfunction can be assessed with cognitive tests and subjective report of difficulties with executive skills. The present study investigated the association between subjective report of executive functioning complaints and time to escitalopram treatment response in older adults with major depressive disorder (MDD). 100 older adults with MDD (58 with executive functioning complaints and 42 without executive functioning complaints) completed a 12-week trial of escitalopram. Treatment response over 12 weeks, as measured by repeated Hamilton Depression Rating Scale scores, was compared for adults with and without executive complaints using mixed-effects modeling. Mixed effects analysis revealed a significant group × time interaction, F(1, 523.34) = 6.00, p = 0.01. Depressed older adults who reported executive functioning complaints at baseline demonstrated a slower response to escitalopram treatment than those without executive functioning complaints. Self-report of executive functioning difficulties may be a useful prognostic indicator for subsequent speed of response to antidepressant medication. Copyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

SPE analysis of high efficiency PMTs for the DEAP-3600 dark matter detector

NASA Astrophysics Data System (ADS)

Olsen, Kevin; Hallin, Aksel; DEAP/CLEAN Collaboration

2011-09-01

The Dark matter Experiment using Argon Pulse-shape discrimination is a collaborative effort to develop a next-generation, tonne-scale dark matter detector at SNOLAB. The detector will feature a single-phase liquid argon (LAr) target surrounded by an array of 266 photomultiplier tubes (PMTs). A new high-efficiency Hamamatsu R877-100 PMT has been delivered to the University of Alberta for evaluation by the DEAP collaboration. The increase in efficiency could lead to a much greater light yield, but other experiments have reported a slower rise time [1],[2]. We have placed the PMT in a small dark box and had a base and preamplifier designed to be used with either an oscilloscope or a multi-channel analyzer. With this setup we have demonstrated the PMT's ability to distinguish single photo-electrons (SPE) and characterized the PMT by measuring the SPE pulse height spectrum, the peak-to-valley ratio, the dark pulse rate, the baseline, time resolution and SPE efficiency for varying the high voltage supplied to the PMT.

Performance Lapses in Children with Attention-Deficit/Hyperactivity Disorder Contribute to Poor Reading Fluency

PubMed Central

Jacobson, Lisa A.; Ryan, Matthew; Denckla, Martha B.; Mostofsky, Stewart H.; Mahone, E. Mark

2013-01-01

Children with Attention-Deficit/Hyperactivity Disorder (ADHD) demonstrate increased response variability compared with controls, which is thought to be associated with deficits in attention regulation and response control that subsequently affect performance of more cognitively demanding tasks, such as reading. The present study examined response variability during a computerized simple reaction time (RT) task in 67 children. Ex-Gaussian analyses separated the response time distribution into normal (mu and sigma) and exponential (tau) components; the association of each with reading fluency was examined. Children with ADHD had significantly slower, more variable, and more skewed RTs compared with controls. After controlling for ADHD symptom severity, tau (but not mu or mean RT) was significantly associated with reduced reading fluency, but not with single word reading accuracy. These data support the growing evidence that RT variability, but not simply slower mean response speed, is the characteristic of youth with ADHD and that longer response time latencies (tau) may be implicated in the poorer academic performance associated with ADHD. PMID:23838684

Performance lapses in children with attention-deficit/hyperactivity disorder contribute to poor reading fluency.

PubMed

Jacobson, Lisa A; Ryan, Matthew; Denckla, Martha B; Mostofsky, Stewart H; Mahone, E Mark

2013-11-01

Children with Attention-Deficit/Hyperactivity Disorder (ADHD) demonstrate increased response variability compared with controls, which is thought to be associated with deficits in attention regulation and response control that subsequently affect performance of more cognitively demanding tasks, such as reading. The present study examined response variability during a computerized simple reaction time (RT) task in 67 children. Ex-Gaussian analyses separated the response time distribution into normal (mu and sigma) and exponential (tau) components; the association of each with reading fluency was examined. Children with ADHD had significantly slower, more variable, and more skewed RTs compared with controls. After controlling for ADHD symptom severity, tau (but not mu or mean RT) was significantly associated with reduced reading fluency, but not with single word reading accuracy. These data support the growing evidence that RT variability, but not simply slower mean response speed, is the characteristic of youth with ADHD and that longer response time latencies (tau) may be implicated in the poorer academic performance associated with ADHD.

61. The World-Wide Inaccessible Web, Part 2: Internet Routes

ERIC Educational Resources Information Center

Baggaley, Jon; Batpurev, Batchuluun; Klaas, Jim

2007-01-01

In the previous report in this series, Web browser loading times were measured in 12 Asian countries, and were found to be up to four times slower than commonly prescribed as acceptable. Failure of webpages to load at all was frequent. The current follow-up study compares these loading times with the complexity of the Internet routes linking the…

Solving large scale structure in ten easy steps with COLA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tassev, Svetlin; Zaldarriaga, Matias; Eisenstein, Daniel J., E-mail: stassev@cfa.harvard.edu, E-mail: matiasz@ias.edu, E-mail: deisenstein@cfa.harvard.edu

2013-06-01

We present the COmoving Lagrangian Acceleration (COLA) method: an N-body method for solving for Large Scale Structure (LSS) in a frame that is comoving with observers following trajectories calculated in Lagrangian Perturbation Theory (LPT). Unlike standard N-body methods, the COLA method can straightforwardly trade accuracy at small-scales in order to gain computational speed without sacrificing accuracy at large scales. This is especially useful for cheaply generating large ensembles of accurate mock halo catalogs required to study galaxy clustering and weak lensing, as those catalogs are essential for performing detailed error analysis for ongoing and future surveys of LSS. As anmore » illustration, we ran a COLA-based N-body code on a box of size 100 Mpc/h with particles of mass ≈ 5 × 10{sup 9}M{sub s}un/h. Running the code with only 10 timesteps was sufficient to obtain an accurate description of halo statistics down to halo masses of at least 10{sup 11}M{sub s}un/h. This is only at a modest speed penalty when compared to mocks obtained with LPT. A standard detailed N-body run is orders of magnitude slower than our COLA-based code. The speed-up we obtain with COLA is due to the fact that we calculate the large-scale dynamics exactly using LPT, while letting the N-body code solve for the small scales, without requiring it to capture exactly the internal dynamics of halos. Achieving a similar level of accuracy in halo statistics without the COLA method requires at least 3 times more timesteps than when COLA is employed.« less

Neuroticism Combined With Slower and More Variable Reaction Time: Synergistic Risk Factors for 7-Year Cognitive Decline in Females

PubMed Central

Shickle, Darren A.; Roberts, Beverly A.; Deary, Ian J.

2012-01-01

Objective. Among adults, slower and more variable reaction times are associated with worse cognitive function and increased mortality risk. Therefore, it is important to elucidate risk factors for reaction time change over the life course. Method. Data from the Health and Lifestyle Survey (HALS) were used to examine predictors of 7-year decline in reaction time (N = 4,260). Regression-derived factor scores were used to summarize general change across 4 reaction time variables: simple mean, 4-choice mean, simple variability, and 4-choice variability (53.52% of variance). Results. Age (B = .02, p < .001) and HALS1 baseline reaction time (B = −.10, p = .001) were significant risk factors for males (N = 1,899). In addition to these variables, in females (N = 2,361), neuroticism was significant and interacted synergistically with baseline reaction time (B = .06, p = .04). Adjustment for physiological variables explained the interaction with neuroticism, suggesting that candidate mechanisms had been identified. Discussion. A priority for future research is to replicate interactions between personality and reaction time in other samples and find specific mechanisms. Stratification of population data on cognitive health by personality and reaction time could improve strategies for identifying those at greater risk of cognitive decline. PMID:22367712

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sreedharan, Priya

The sudden release of toxic contaminants that reach indoor spaces can be hazardousto building occupants. To respond effectively, the contaminant release must be quicklydetected and characterized to determine unobserved parameters, such as release locationand strength. Characterizing the release requires solving an inverse problem. Designinga robust real-time sensor system that solves the inverse problem is challenging becausethe fate and transport of contaminants is complex, sensor information is limited andimperfect, and real-time estimation is computationally constrained.This dissertation uses a system-level approach, based on a Bayes Monte Carloframework, to develop sensor-system design concepts and methods. I describe threeinvestigations that explore complex relationships amongmore » sensors, network architecture,interpretation algorithms, and system performance. The investigations use data obtainedfrom tracer gas experiments conducted in a real building. The influence of individual sensor characteristics on the sensor-system performance for binary-type contaminant sensors is analyzed. Performance tradeoffs among sensor accuracy, threshold level and response time are identified; these attributes could not be inferred without a system-level analysis. For example, more accurate but slower sensors are found to outperform less accurate but faster sensors. Secondly, I investigate how the sensor-system performance can be understood in terms of contaminant transport processes and the model representation that is used to solve the inverse problem. The determination of release location and mass are shown to be related to and constrained by transport and mixing time scales. These time scales explain performance differences among different sensor networks. For example, the effect of longer sensor response times is comparably less for releases with longer mixing time scales. The third investigation explores how information fusion from heterogeneous sensors may improve the sensor-system performance and offset the need for more contaminant sensors. Physics- and algorithm-based frameworks are presented for selecting and fusing information from noncontaminant sensors. The frameworks are demonstrated with door-position sensors, which are found to be more useful in natural airflow conditions, but which cannot compensate for poor placement of contaminant sensors. The concepts and empirical findings have the potential to help in the design of sensor systems for more complex building systems. The research has broader relevance to additional environmental monitoring problems, fault detection and diagnostics, and system design.« less

Speed-difficulty trade-off in speech: Chinese versus English

PubMed Central

Sun, Yao; Latash, Elizaveta M.; Mikaelian, Irina L.

2011-01-01

This study continues the investigation of the previously described speed-difficulty trade-off in picture description tasks. In particular, we tested a hypothesis that the Mandarin Chinese and American English are similar in showing logarithmic dependences between speech time and index of difficulty (ID), while they differ significantly in the amount of time needed to describe simple pictures, this difference increases for more complex pictures, and it is associated with a proportional difference in the number of syllables used. Subjects (eight Chinese speakers and eight English speakers) were tested in pairs. One subject (the Speaker) described simple pictures, while the other subject (the Performer) tried to reproduce the pictures based on the verbal description as quickly as possible with a set of objects. The Chinese speakers initiated speech production significantly faster than the English speakers. Speech time scaled linearly with ln(ID) in all subjects, but the regression coefficient was significantly higher in the English speakers as compared with the Chinese speakers. The number of errors was somewhat lower in the Chinese participants (not significantly). The Chinese pairs also showed a shorter delay between the initiation of speech and initiation of action by the Performer, shorter movement time by the Performer, and shorter overall performance time. The number of syllables scaled with ID, and the Chinese speakers used significantly smaller numbers of syllables. Speech rate was comparable between the two groups, about 3 syllables/s; it dropped for more complex pictures (higher ID). When asked to reproduce the same pictures without speaking, movement time scaled linearly with ln(ID); the Chinese performers were slower than the English performers. We conclude that natural languages show a speed-difficulty trade-off similar to Fitts’ law; the trade-offs in movement and speech production are likely to originate at a cognitive level. The time advantage of the Chinese participants originates not from similarity of the simple pictures and Chinese written characters and not from more sloppy performance. It is linked to using fewer syllables to transmit the same information. We suggest that natural languages may differ by informational density defined as the amount of information transmitted by a given number of syllables. PMID:21479658

Disease spread across multiple scales in a spatial hierarchy: effect of host spatial structure and of inoculum quantity and distribution.

PubMed

Gosme, Marie; Lucas, Philippe

2009-07-01

Spatial patterns of both the host and the disease influence disease spread and crop losses. Therefore, the manipulation of these patterns might help improve control strategies. Considering disease spread across multiple scales in a spatial hierarchy allows one to capture important features of epidemics developing in space without using explicitly spatialized variables. Thus, if the system under study is composed of roots, plants, and planting hills, the effect of host spatial pattern can be studied by varying the number of plants per planting hill. A simulation model based on hierarchy theory was used to simulate the effects of large versus small planting hills, low versus high level of initial infections, and aggregated versus uniform distribution of initial infections. The results showed that aggregating the initially infected plants always resulted in slower epidemics than spreading out the initial infections uniformly. Simulation results also showed that, in most cases, disease epidemics were slower in the case of large host aggregates (100 plants/hill) than with smaller aggregates (25 plants/hill), except when the initially infected plants were both numerous and spread out uniformly. The optimal strategy for disease control depends on several factors, including initial conditions. More importantly, the model offers a framework to account for the interplay between the spatial characteristics of the system, rates of infection, and aggregation of the disease.

Microtubule dissassembly in vivo: intercalary destabilization and breakdown of microtubules in the heliozoan Actinocoryne contractilis

PubMed Central

1992-01-01

In the marine heliozoan Actinocoryne contractilis, uninterrupted rods of microtubules stiffen the axopodia and the stalk. Stimulation in sea water elicits an extremely fast contraction (millisecond range) accompanied by almost complete Mt dissociation. Using high-speed cinematography and light transmittance measurements, we have studied the process of Mt disassembly in real time. In sea water, Mt disassembly follows an exponential decrease (mean half time of 4 ms) or proceeds by short steps. Cell contraction and Mt disassembly have been inhibited or slowed down through the use of artificial media. Although kinetics are slower (mean half time of 3 s), the curves of the length change against time look similar. The rapid as well as the slower process are accompanied by the formation of breakpoints on the stalk, from which disassembly proceeds. In specimens fixed during the slowed contraction, the presence across the Mt rods, of a single or multiple destabilization band that may consist of granular material and polymorphic forms of tubulin supports the hypothesis of "intercalary destabilization and breakdown" of axonemal Mts. PMID:1639845

Diffusion Barrier Selection from Refractory Metals (Zr, Mo and Nb) via Interdiffusion Investigation for U-Mo RERTR Fuel Alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

K. Huang; C. Kammerer; D. D. Keiser, Jr.

2014-04-01

U-Mo alloys are being developed as low enrichment monolithic fuel under the Reduced Enrichment for Research and Test Reactor (RERTR) Program. Diffusional interactions between the U-Mo fuel alloy and Al-alloy cladding within the monolithic fuel plate construct necessitate incorporation of a barrier layer. Fundamentally, a diffusion barrier candidate must have good thermal conductivity, high melting point, minimal metallurgical interaction, and good irradiation performance. Refractory metals, Zr, Mo, and Nb are considered based on their physical properties, and the diffusion behavior must be carefully examined first with U-Mo fuel alloy. Solid-to-solid U-10wt.%Mo vs. Mo, Zr, or Nb diffusion couples were assembledmore » and annealed at 600, 700, 800, 900 and 1000 degrees C for various times. The interdiffusion microstructures and chemical composition were examined via scanning electron microscopy and electron probe microanalysis, respectively. For all three systems, the growth rate of interdiffusion zone were calculated at 1000, 900 and 800 degrees C under the assumption of parabolic growth, and calculated for lower temperature of 700, 600 and 500 degrees C according to Arrhenius relationship. The growth rate was determined to be about 10 3 times slower for Zr, 10 5 times slower for Mo and 10 6 times slower for Nb, than the growth rates reported for the interaction between the U-Mo fuel alloy and pure Al or Al-Si cladding alloys. Zr, however was selected as the barrier metal due to a concern for thermo- mechanical behavior of UMo/Nb interface observed from diffusion couples, and for ductile-to-brittle transition of Mo near room temperature.« less

The behavior of an opponent alters pacing decisions in 4-km cycling time trials.

PubMed

Konings, Marco J; Schoenmakers, Patrick P J M; Walker, Andrew J; Hettinga, Florentina J

2016-05-01

The present study aimed to explore how athletes respond to different behaviors of their opponents. Twelve moderately to highly physically active participants with at least two years of cycling experience completed four 4-km time trials on a Velotron cycle ergometer. After a familiarization time trial (FAM), participants performed three experimental time trials in randomized order with no opponent (NO), a virtual opponent who started slower and finished faster compared to FAM (OP-SLOWFAST), or a virtual opponent who started faster and finished slower compared to FAM (OP-FASTSLOW). Repeated-measures ANOVAs (P<0.05) were used to examine differences in pacing and performance related to power output, velocity and RPE. OP-SLOWFAST and OP-FASTSLOW were completed faster compared to NO (385.5±27.5, 385.0±28.6, and 390.6±29.3s, respectively). An interaction effect for condition×distance (F=3.944, P<0.001) indicated differences in pacing profiles between conditions. Post-hoc analysis revealed that a less aggressive starting strategy was adopted in NO compared to OP-FASTSLOW and OP-SLOWFAST during the initial 1000m. Finally, a faster starting opponent evokes higher power outputs by the participants in the initial 750m compared to a slower starting opponent. The present study is the first to show that the behavior of an opponent affects pacing-related decisions in laboratory-controlled conditions. Our findings support the recently proposed interdependence of perception and action, and emphasize the interaction with the environment as an important determinant for an athlete's pacing decisions, especially during the initial stages of a race. Copyright © 2016 Elsevier Inc. All rights reserved.

Picosecond Phase Grating Spectroscopy of Hemoglobin and Myoglobin: Vibrational Relaxation and Global Protein Motions.

NASA Astrophysics Data System (ADS)

Genberg, Laura Lynn

The vibrational energy relaxation pathways from optically excited met heme proteins have been studied using the technique of picosecond phase grating spectroscopy. Vibrational energy transfer from the porphyrin ring to the protein backbone leads to extensive delocalization of the energy in the protein matrix which is efficiently transferred to the water interface in less than 20 ps. A slower relaxation process on the nanosecond time scale is also observed. The slow relaxation component is attributed to slow conformational relaxation processes of high potential energy states of the heme proteins. These states are accessed during the high internal energy conditions of the optically excited molecules. In addition, a detailed theoretical analysis of this form of spectroscopy is presented that explains the effects of delayed thermal energy deposition on grating dynamics. The effects of optical pulse shape and duration are also treated. The observable in this technique is not an electronic polarization, but is derived from a response of the material fields to changes in the lattice temperature. Phase grating spectroscopy is also used to observe picosecond tertiary structural changes in both myoglobin and hemoglobin following CO photodissociation. The original interest in this experiment was to ascertain whether local minima are accessed during the highly exothermic conditions following photodissociation, as was observed in the met heme studies. Photodissociation of CO induces a well defined ligated to deoxy structure transition that is important to the functionality of these proteins. Using grating spectroscopy, protein driven density waves are observed on a picosecond time scale. These waves are launched by the tertiary structural changes that occur in both hemoglobin and myoglobin. The exact shape and amplitude of these waves reveal the time scale for the motion as well as the energetics for these protein motions. This result demonstrates that tertiary structure changes are global in nature and occur on an extremely fast time scale. This provides new insight into the biomechanics of conformational changes in proteins and lends support to theoretical models invoking stored strain energy as the driving force for large amplitude correlated motions.

6 CFR 5.5 - Timing of responses to requests.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the number of pages involved. If a component does so, it shall advise requesters in its slower track(s...) Requests and appeals will be taken out of order and given expedited treatment whenever it is determined...

40 CFR 1601.24 - Timing of responses to requests.

Code of Federal Regulations, 2012 CFR

2012-07-01

... of pages involved. If the agency does so, it shall advise requesters assigned to its slower track of... appeals will be taken out of order and given expedited treatment whenever it is determined that they...

40 CFR 1601.24 - Timing of responses to requests.

Code of Federal Regulations, 2011 CFR

2011-07-01

... of pages involved. If the agency does so, it shall advise requesters assigned to its slower track of... appeals will be taken out of order and given expedited treatment whenever it is determined that they...

Retardation of ice crystallization by short peptides

NASA Astrophysics Data System (ADS)

Kim, Jun Soo; Yethiraj, Arun

2009-03-01

The effect of short peptides on the growth of ice crystals is studied using molecular dynamics simulations. The simulations focus on two sequences (Gly-Pro-Ala-Gly and Gly-Gly-Ala-Gly) that are found in collagen hydrolysate, a substance that is known to retard crystal growth. In the absence of peptides, the growth of ice crystal in the solution with the ice/water interface is observed in at a rate comparable to the experimental data. When peptides are present in the liquid phase, the crystal growth is retarded to a significant extent compared to the pure water. It is found that Gly-Pro-Ala-Gly is more effective (crystallization is up to 5 times slower than in its absence) than Gly-Gly-Ala-Gly (up to 3 times slower) implying that the role of the proline residue is important. The mechanism can be understood in the nature of binding of the peptides to the growing crystal.

Balance training reduces falls risk in older individuals with type 2 diabetes.

PubMed

Morrison, Steven; Colberg, Sheri R; Mariano, Mira; Parson, Henri K; Vinik, Arthur I

2010-04-01

This study assessed the effects of balance/strength training on falls risk and posture in older individuals with type 2 diabetes. Sixteen individuals with type 2 diabetes and 21 age-matched control subjects (aged 50-75 years) participated. Postural stability and falls risk was assessed before and after a 6-week exercise program. Diabetic individuals had significantly higher falls risk score compared with control subjects. The diabetic group also exhibited evidence of mild-to-moderate neuropathy, slower reaction times, and increased postural sway. Following exercise, the diabetic group showed significant improvements in leg strength, faster reaction times, decreased sway, and, consequently, reduced falls risk. Older individuals with diabetes had impaired balance, slower reactions, and consequently a higher falls risk than age-matched control subjects. However, all these variables improved after resistance/balance training. Together these results demonstrate that structured exercise has wide-spread positive effects on physiological function for older individuals with type 2 diabetes.

Britte reaction of a high-temperature ion melt

NASA Astrophysics Data System (ADS)

Zimanowski, B.; Büttner, R.; Nestler, J.

1997-05-01

An experimental study on explosive interaction between transparent melt (T = 1120 K) and entrapped water (T = 300 K) has been performed. Intense explosions occurred, resulting from catastrophic fragmentation of the melt and increasing heat transfer to the water in a cascading process. In earlier experiments a quasi-isochoric brittle reaction of the melt was identified to be the major explosion mechanism. Using a transparent melt, this brittle reaction could directly be observed by high-speed cinematography. The pictures revealed two fragmentation mechanisms: a) formation of leading cracks (mm to cm scale) due to excess water pressure, and b) slower μm scaled melt fragmentation induced by strain build-up in the melt during rapid cooling.

Hot water, fresh beer, and salt

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawford, F.S.

1990-11-01

In the hot chocolate effect'' the best musical scales (those with the finest tone quality, largest range, and best tempo) are obtained by adding salt to a glass of hot water supersaturated with air. Good scales can also be obtained by adding salt to a glass of freshly opened beer (supersaturated with CO{sub 2}) provided you first (a) get rid of much of the excess CO{sub 2} so as to produce smaller, hence slower, rising bubbles, and (b) get rid of the head of foam, which damps the standing wave and ruins the tone quality. Finally the old question, Domore » ionizing particles produce bubbles in fresh beer '' is answered experimentally.« less

Scaling up of renewable chemicals.

PubMed

Sanford, Karl; Chotani, Gopal; Danielson, Nathan; Zahn, James A

2016-04-01

The transition of promising technologies for production of renewable chemicals from a laboratory scale to commercial scale is often difficult and expensive. As a result the timeframe estimated for commercialization is typically underestimated resulting in much slower penetration of these promising new methods and products into the chemical industries. The theme of 'sugar is the next oil' connects biological, chemical, and thermochemical conversions of renewable feedstocks to products that are drop-in replacements for petroleum derived chemicals or are new to market chemicals/materials. The latter typically offer a functionality advantage and can command higher prices that result in less severe scale-up challenges. However, for drop-in replacements, price is of paramount importance and competitive capital and operating expenditures are a prerequisite for success. Hence, scale-up of relevant technologies must be interfaced with effective and efficient management of both cell and steel factories. Details involved in all aspects of manufacturing, such as utilities, sterility, product recovery and purification, regulatory requirements, and emissions must be managed successfully. Copyright © 2016 Elsevier Ltd. All rights reserved.

Smooth DNA transport through a narrowed pore geometry.

PubMed

Carson, Spencer; Wilson, James; Aksimentiev, Aleksei; Wanunu, Meni

2014-11-18

Voltage-driven transport of double-stranded DNA through nanoscale pores holds much potential for applications in quantitative molecular biology and biotechnology, yet the microscopic details of translocation have proven to be challenging to decipher. Earlier experiments showed strong dependence of transport kinetics on pore size: fast regular transport in large pores (> 5 nm diameter), and slower yet heterogeneous transport time distributions in sub-5 nm pores, which imply a large positional uncertainty of the DNA in the pore as a function of the translocation time. In this work, we show that this anomalous transport is a result of DNA self-interaction, a phenomenon that is strictly pore-diameter dependent. We identify a regime in which DNA transport is regular, producing narrow and well-behaved dwell-time distributions that fit a simple drift-diffusion theory. Furthermore, a systematic study of the dependence of dwell time on DNA length reveals a single power-law scaling of 1.37 in the range of 35-20,000 bp. We highlight the resolution of our nanopore device by discriminating via single pulses 100 and 500 bp fragments in a mixture with >98% accuracy. When coupled to an appropriate sequence labeling method, our observation of smooth DNA translocation can pave the way for high-resolution DNA mapping and sizing applications in genomics.

Measuring subjective sleepiness at work in hospital nurses: validation of a modified delivery format of the Karolinska Sleepiness Scale.

PubMed

Geiger Brown, Jeanne; Wieroney, Margaret; Blair, Lori; Zhu, Shijun; Warren, Joan; Scharf, Steven M; Hinds, Pamela S

2014-12-01

Sleepiness during the work shift is common and can be hazardous to workers and, in the case of nurses, to patients under their care. Thus, measuring sleepiness in occupational studies is an important component of workplace health and safety. The Karolinska Sleepiness Scale (KSS) is usually used as a momentary assessment of a respondent's state of sleepiness; however, end-of-shift measurement is sometimes preferred based on the study setting. We assessed the predictive validity of the KSS as an end-of-shift recall measurement, asking for "average" sleepiness over the shift and "highest" level of sleepiness during the shift. Hospital registered nurses (N=40) working 12-h shifts completed an end-of-shift diary over 4 weeks that included the National Aeronautical and Space Administration Task Load Index (NASA-TLX) work intensity items and the KSS (498 shifts over 4 weeks). Vigilant attention was assessed by measuring reaction time, lapses, and anticipations using a 10-min performance vigilance task (PVT) at the end of the shift. The Horne-Ostberg Questionnaire, Epworth Sleepiness Scale, General Sleep Disturbance Scale, and Cleveland Sleep Habits Questionnaire were also collected at baseline to assess factors that could be associated with higher sleepiness. We hypothesized that higher KSS scores would correlate with vigilant attention parameters reflective of sleepiness (slower reaction times and more lapses and anticipations on a performance vigilance task) and also with those factors known to produce higher sleepiness. These factors included the following: (1) working night shifts, especially for those with "morningness" trait; (2) working sequential night shifts; (3) having low physical and mental work demands and low time pressure; (4) having concomitant organic sleep disorders; and (5) having greater "trait" sleepiness (Epworth Sleepiness Scale). Linear mixed models and generalized linear mixed models were used to test associations that could assess the predictive validity of this format of administering the KSS. Greater sleepiness, as measured by higher KSS scores, was found on shifts with nurses working night shift, the third sequential night compared to the first, those with sleep disorder symptoms (especially insomnia), and in nurses with trait sleepiness on the Epworth scale. Less sleepiness (lower KSS scores) was seen in shifts with a high level of time pressure and in nurses with a biologic predisposition to be more alert in the morning (morningness trait) who worked the day shift. We found partial support for using the Karolinska Sleepiness Scale in the recalled format based on our multiple tests of predictive validity.

Flexibility of Expressive Timing in Repeated Musical Performances

PubMed Central

Demos, Alexander P.; Lisboa, Tânia; Chaffin, Roger

2016-01-01

Performances by soloists in the Western classical tradition are normally highly prepared, yet must sound fresh and spontaneous. How do musicians manage this? We tested the hypothesis that they achieve the necessary spontaneity by varying the musical gestures that express their interpretation of a piece. We examined the tempo arches produced by final slowing at the ends of phrases in performances of J. S. Bach’s No. 6 (Prelude) for solo cello (12 performances) and the Italian Concerto (Presto) for solo piano (eight performances). The performances were given by two experienced concert soloists during a short time period (3½ months for the Prelude, 2 weeks for the Presto) after completing their preparations for public performance. We measured the tempo of each bar or half-bar, and the stability of tempo across performances (difference of the tempo of each bar/half bar from each of the other performances). There were phrase arches for both tempo and stability with slower, less stable tempi at beginnings and ends of phrases and faster, more stable tempi mid-phrase. The effects of practice were complex. Tempo decreased overall with practice, while stability increased in some bars and decreased in others. One effect of practice may be to imbue well-learned, automatic motor sequences with freshness and spontaneity through cognitive control at phrase boundaries where slower tempi and decreased stability provide opportunities for slower cognitive processes to modulate rapid automatic motor sequences. PMID:27757089

Locomotion in Extinct Giant Kangaroos: Were Sthenurines Hop-Less Monsters?

PubMed Central

Janis, Christine M.; Buttrill, Karalyn; Figueirido, Borja

2014-01-01

Sthenurine kangaroos (Marsupialia, Diprotodontia, Macropodoidea) were an extinct subfamily within the family Macropodidae (kangaroos and rat-kangaroos). These “short-faced browsers” first appeared in the middle Miocene, and radiated in the Plio-Pleistocene into a diversity of mostly large-bodied forms, more robust than extant forms in their build. The largest (Procoptodon goliah) had an estimated body mass of 240 kg, almost three times the size of the largest living kangaroos, and there is speculation whether a kangaroo of this size would be biomechanically capable of hopping locomotion. Previously described aspects of sthenurine anatomy (specialized forelimbs, rigid lumbar spine) would limit their ability to perform the characteristic kangaroo pentapedal walking (using the tail as a fifth limb), an essential gait at slower speeds as slow hopping is energetically unfeasible. Analysis of limb bone measurements of sthenurines in comparison with extant macropodoids shows a number of anatomical differences, especially in the large species. The scaling of long bone robusticity indicates that sthenurines are following the “normal” allometric trend for macropodoids, while the large extant kangaroos are relatively gracile. Other morphological differences are indicative of adaptations for a novel type of locomotor behavior in sthenurines: they lacked many specialized features for rapid hopping, and they also had anatomy indicative of supporting their body with an upright trunk (e.g., dorsally tipped ischiae), and of supporting their weight on one leg at a time (e.g., larger hips and knees, stabilized ankle joint). We propose that sthenurines adopted a bipedal striding gait (a gait occasionally observed in extant tree-kangaroos): in the smaller and earlier forms, this gait may have been employed as an alternative to pentapedal locomotion at slower speeds, while in the larger Pleistocene forms this gait may have enabled them to evolve to body sizes where hopping was no longer a feasible form of more rapid locomotion. PMID:25333823

Comprehensive neurocognitive assessment of patients with anorexia nervosa.

PubMed

Phillipou, Andrea; Gurvich, Caroline; Castle, David Jonathan; Abel, Larry Allen; Rossell, Susan Lee

2015-12-22

To utilise a comprehensive cognitive battery to gain a better understanding of cognitive performance in anorexia nervosa (AN). Twenty-six individuals with AN and 27 healthy control participants matched for age, gender and premorbid intelligence, participated in the study. A standard cognitive battery, the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery, was used to investigate performance on seven cognitive domains with the use of 10 different tasks: speed of processing [Brief Assessment Of Cognition In Schizophrenia: Symbol Coding, Category Fluency: Animal Naming (Fluency) and Trail Making Test: Part A], attention/vigilance [Continuous Performance Test - Identical Pairs (CPT-IP)], working memory [Wechsler Memory Scale (WMS(®)-III): Spatial Span, and Letter-Number Span (LNS)], verbal learning [Hopkins Verbal Learning Test - Revised], visual learning [Brief Visuospatial Memory Test - Revised], reasoning and problem solving [Neuropsychological Assessment Battery: Mazes], and social cognition [Mayer-Salovey-Caruso Emotional Intelligence Test: Managing Emotions]. Statistical analyses involved the use of multivariate and univariate analyses of variance. Analyses conducted on the cognitive domain scores revealed no overall significant difference between groups nor any interaction between group and domain score [F(1,45) = 0.73, P = 0.649]. Analyses conducted on each of the specific tasks within the cognitive domains revealed significantly slower reaction times for false alarm responses on the CPT-IP task in AN [F(1,51) = 12.80, P < 0.01, Cohen's d = 0.982] and a trend towards poorer performance in AN on the backward component of the WMS(®)-III Spatial Span task [F(1,51) = 5.88, P = 0.02, Cohen's d = -0.665]. The finding of slower reaction times of false alarm responses is, however, limited due to the small number of false alarm responses for either group. The findings are discussed in terms of poorer capacity to manipulate and process visuospatial material in AN.

Dual-tasks and walking fast: relationship to extra-pyramidal signs in advanced Alzheimer disease.

PubMed

Camicioli, Richard; Bouchard, Thomas; Licis, Lisa

2006-10-25

Extra-pyramidal signs (EPS) and cadence predicted falls risk in patients with advanced Alzheimer disease (AD). Dual task performance predicts falls with variable success. Dual-task performance and walking fast were examined in advanced AD patients with EPS (EPS+, >3 modified Unified Parkinson's Disease Rating Scale [UPDRS] signs) or without EPS (EPS-, three or less UPDRS signs). Demographics, mental and functional status, behavioral impairment, EPS, and quantitative gait measures (GaitRite) were determined. The effects of an automatic dual-task (simple counting) and of walking fast on spatial and temporal gait characteristics were compared between EPS+ and EPS- subjects using a repeated measures design. Cadence decreased, while stride time, swing time and variability in swing time increased with the dual task. Results were insignificant after adjusting for secondary task performance. With walking fast, speed, cadence and stride length increased while stride time, swing time and double support time decreased. Although EPS+ subjects were slower and had decreased stride length, dual task and walking fast effects did not differ from EPS- subjects. Patient characteristics, the type of secondary task and the specific gait measures examined vary in the literature. In this moderately to severely demented population, EPS did not affect "unconscious" (dual task) or "conscious" (walking fast) gait modulation. Given their high falls risk, and retained ability to modulate walking, EPS+ AD patients may be ideal candidates for interventions aimed at preventing falls.

Finite-size effects in the short-time height distribution of the Kardar-Parisi-Zhang equation

NASA Astrophysics Data System (ADS)

Smith, Naftali R.; Meerson, Baruch; Sasorov, Pavel

2018-02-01

We use the optimal fluctuation method to evaluate the short-time probability distribution P(H, L, t) of height at a single point, H=h(x=0, t) , of the evolving Kardar-Parisi-Zhang (KPZ) interface h(x, t) on a ring of length 2L. The process starts from a flat interface. At short times typical (small) height fluctuations are unaffected by the KPZ nonlinearity and belong to the Edwards-Wilkinson universality class. The nonlinearity, however, strongly affects the (asymmetric) tails of P(H) . At large L/\\sqrt{t} the faster-decaying tail has a double structure: it is L-independent, -\\lnP˜≤ft\\vert H\\right\\vert 5/2/t1/2 , at intermediately large \\vert H\\vert , and L-dependent, -\\lnP˜ ≤ft\\vert H\\right\\vert 2L/t , at very large \\vert H\\vert . The transition between these two regimes is sharp and, in the large L/\\sqrt{t} limit, behaves as a fractional-order phase transition. The transition point H=Hc+ depends on L/\\sqrt{t} . At small L/\\sqrt{t} , the double structure of the faster tail disappears, and only the very large-H tail, -\\lnP˜ ≤ft\\vert H\\right\\vert 2L/t , is observed. The slower-decaying tail does not show any L-dependence at large L/\\sqrt{t} , where it coincides with the slower tail of the GOE Tracy-Widom distribution. At small L/\\sqrt{t} this tail also has a double structure. The transition between the two regimes occurs at a value of height H=Hc- which depends on L/\\sqrt{t} . At L/\\sqrt{t} \\to 0 the transition behaves as a mean-field-like second-order phase transition. At \\vert H\\vert <\\vert H_c-\\vert the slower tail behaves as -\\lnP˜ ≤ft\\vert H\\right\\vert 2L/t , whereas at \\vert H\\vert >\\vert H_c-\\vert it coincides with the slower tail of the GOE Tracy-Widom distribution.

Cognitive changes after saline or plasmalyte infusion in healthy volunteers: a multiple blinded, randomized, cross-over trial.

PubMed

Story, David A; Lees, Lucy; Weinberg, Laurence; Teoh, Soon-Yee; Lee, Katherine J; Velissaris, Sarah; Bellomo, Rinaldo; Wilson, Sarah J

2013-09-01

In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann's (Ringer's lactate) solution. The authors tested the hypothesis that saline infusion would produce greater adverse cognitive changes than Plasmalyte infusion. The authors conducted a randomized, cross-over, multiple blinded study of healthy adult volunteers. On separate days, participants received 30 ml/kg over 1 h of either 0.9% saline or Plasmalyte with the order randomly allocated. Plasma chemistry was tested on venous samples. As part of a battery of cognitive tests our primary endpoint was the reaction time index after infusion. The authors studied 25 participants. Plasma chloride was greater after saline than after Plasmalyte: mean difference 5.4 mM (95% CI, 4.1-6.6 mM; P < 0.001). Saline was also associated with greater metabolic acidosis: base-excess 2.5 mM more negative (95% CI, 1.9-3.0 mM more negative; P < 0.001). There was no evidence of a difference in the reaction time index between the two interventions: mean reaction time index 394 ms (SD, 72) after saline versus 385 ms (SD, 55) after Plasmalyte. Difference: saline 9 ms slower (95% CI, 30 ms slower to 12 ms faster; P = 0.39). There were minimal differences in the other cognitive and mood tests. Despite expected differences in plasma chemistry, the authors found that measures of cognition did not differ after infusions of Plasmalyte or saline.

Growth rate effects on the formation of dislocation loops around deep helium bubbles in Tungsten

DOE PAGES

Sandoval, Luis; Perez, Danny; Uberuaga, Blas P.; ...

2016-11-15

Here, the growth process of spherical helium bubbles located 6 nm below a (100) surface is studied using molecular dynamics and parallel replica dynamics simulations, over growth rates from 10 6 to 10 12 helium atoms per second. Slower growth rates lead to a release of pressure and lower helium content as compared with fast growth cases. In addition, at slower growth rates, helium bubbles are not decorated by multiple dislocation loops, as these tend to merge or emit given sufficient time. At faster rates, dislocation loops nucleate faster than they can emit, leading to a more complicated dislocation structuremore » around the bubble.« less

Behavioral Priming: It's All in the Mind, but Whose Mind?

PubMed Central

Doyen, Stéphane; Klein, Olivier; Pichon, Cora-Lise; Cleeremans, Axel

2012-01-01

The perspective that behavior is often driven by unconscious determinants has become widespread in social psychology. Bargh, Chen, and Burrows' (1996) famous study, in which participants unwittingly exposed to the stereotype of age walked slower when exiting the laboratory, was instrumental in defining this perspective. Here, we present two experiments aimed at replicating the original study. Despite the use of automated timing methods and a larger sample, our first experiment failed to show priming. Our second experiment was aimed at manipulating the beliefs of the experimenters: Half were led to think that participants would walk slower when primed congruently, and the other half was led to expect the opposite. Strikingly, we obtained a walking speed effect, but only when experimenters believed participants would indeed walk slower. This suggests that both priming and experimenters' expectations are instrumental in explaining the walking speed effect. Further, debriefing was suggestive of awareness of the primes. We conclude that unconscious behavioral priming is real, while real, involves mechanisms different from those typically assumed to cause the effect. PMID:22279526

Switching speeds in NCAP displays: dependence on collection angle and wavelength

NASA Astrophysics Data System (ADS)

Reamey, Robert H.; Montoya, Wayne; Wartenberg, Mark

1991-06-01

The on and off switching speeds of nematic droplet-polymer films (NCAP) are shown to depend on the collection angle (f/#) and the wavelength of the light used in the measurement. Conventional twisted nematic liquid crystal displays have switching speeds which depend little on these factors. The switching speed dependence on collection angle (f/#) and wavelength for nematic droplet-polymer films is inherent to the mechanism by which light is modulated in these films. This mechanism is the scattering of light by the nematic droplets. The on times become faster and the off times become slower as the collection angle of detection is increased. The overall change in switching speed can be large. Greater than 100X changes in off time have been observed. As the wavelength of the light used to interrogate the sample is increased (blue yields green yields red) the on times become faster and the off times become slower. This dependence of switching speed on wavelength is apparent at all collection angles. An awareness of these effects is necessary when developing nematic droplet-polymer films for display applications and when comparing switching speed data from different sources.

Motion detection, novelty filtering, and target tracking using an interferometric technique with a GaAs phase conjugate mirror

NASA Technical Reports Server (NTRS)

Cheng, Li-Jen (Inventor); Liu, Tsuen-Hsi (Inventor)

1990-01-01

A method and apparatus is disclosed for detecting and tracking moving objects in a noise environment cluttered with fast-and slow-moving objects and other time-varying background. A pair of phase conjugate light beams carrying the same spatial information commonly cancel each other out through an image subtraction process in a phase conjugate interferometer, wherein gratings are formed in a fast photo-refractive phase conjugate mirror material. In the steady state, there is no output. When the optical path of one of the two phase conjugate beams is suddenly changed, the return beam loses its phase conjugate nature and the inter-ferometer is out of balance, resulting in an observable output. The observable output lasts until the phase conjugate nature of the beam has recovered. The observable time of the output signal is roughly equal to the formation time of the grating. If the optical path changing time is slower than the formation time, the change of optical path becomes unobservable, because the index grating can follow the change. Thus, objects traveling at speeds which result in a path changing time which is slower than the formation time are not observable and do not clutter the output image view.

Fluid dynamics analysis of a gas attenuator for X-ray FELs under high-repetition-rate operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Bo; Wu, Juhao; Raubenheimer, Tor O.

Newtonian fluid dynamics simulations were performed using the Navier–Stokes–Fourier formulations to elucidate the short time-scale (µs and longer) evolution of the density and temperature distributions in an argon-gas-filled attenuator for an X-ray free-electron laser under high-repetition-rate operation. Both hydrodynamic motions of the gas molecules and thermal conductions were included in a finite-volume calculation. It was found that the hydrodynamic wave motions play the primary role in creating a density depression (also known as a filament) by advectively transporting gas particles away from the X-ray laser–gas interaction region, where large pressure and temperature gradients have been built upon the initial energymore » depositionviaX-ray photoelectric absorption and subsequent thermalization. Concurrent outward heat conduction tends to reduce the pressure in the filament core region, generating a counter gas flow to backfill the filament, but on an initially slower time scale. If the inter-pulse separation is sufficiently short so the filament cannot recover, the depth of the filament progressively increases as the trailing pulses remove additional gas particles. Since the rate of hydrodynamic removal decreases while the rate of heat conduction back flow increases as time elapses, the two competing mechanisms ultimately reach a dynamic balance, establishing a repeating pattern for each pulse cycle. Finally, by performing simulations at higher repetition rates but lower per pulse energies while maintaining a constant time-averaged power, the amplitude of the hydrodynamic motion per pulse becomes smaller, and the evolution of the temperature and density distributions approach asymptotically towards, as expected, those calculated for a continuous-wave input of the equivalent power.« less

Fluid dynamics analysis of a gas attenuator for X-ray FELs under high-repetition-rate operation

DOE PAGES

Yang, Bo; Wu, Juhao; Raubenheimer, Tor O.; ...

2017-05-01

Newtonian fluid dynamics simulations were performed using the Navier–Stokes–Fourier formulations to elucidate the short time-scale (µs and longer) evolution of the density and temperature distributions in an argon-gas-filled attenuator for an X-ray free-electron laser under high-repetition-rate operation. Both hydrodynamic motions of the gas molecules and thermal conductions were included in a finite-volume calculation. It was found that the hydrodynamic wave motions play the primary role in creating a density depression (also known as a filament) by advectively transporting gas particles away from the X-ray laser–gas interaction region, where large pressure and temperature gradients have been built upon the initial energymore » depositionviaX-ray photoelectric absorption and subsequent thermalization. Concurrent outward heat conduction tends to reduce the pressure in the filament core region, generating a counter gas flow to backfill the filament, but on an initially slower time scale. If the inter-pulse separation is sufficiently short so the filament cannot recover, the depth of the filament progressively increases as the trailing pulses remove additional gas particles. Since the rate of hydrodynamic removal decreases while the rate of heat conduction back flow increases as time elapses, the two competing mechanisms ultimately reach a dynamic balance, establishing a repeating pattern for each pulse cycle. Finally, by performing simulations at higher repetition rates but lower per pulse energies while maintaining a constant time-averaged power, the amplitude of the hydrodynamic motion per pulse becomes smaller, and the evolution of the temperature and density distributions approach asymptotically towards, as expected, those calculated for a continuous-wave input of the equivalent power.« less

Demonstration of 720×720 optical fast circuit switch for intra-datacenter networks

NASA Astrophysics Data System (ADS)

Ueda, Koh; Mori, Yojiro; Hasegawa, Hiroshi; Matsuura, Hiroyuki; Ishii, Kiyo; Kuwatsuka, Haruhiko; Namiki, Shu; Sato, Ken-ichi

2016-03-01

Intra-datacenter traffic is growing more than 20% a year. In typical datacenters, many racks/pods including servers are interconnected via multi-tier electrical switches. The electrical switches necessitate power-consuming optical-to- electrical (OE) and electrical-to-optical (EO) conversion, the power consumption of which increases with traffic. To overcome this problem, optical switches that eliminate costly OE and EO conversion and enable low power consumption switching are being investigated. There are two major requirements for the optical switch. First, it must have a high port count to construct reduced tier intra-datacenter networks. Second, switching speed must be short enough that most of the traffic load can be offloaded from electrical switches. Among various optical switches, we focus on those based on arrayed-waveguide gratings (AWGs), since the AWG is a passive device with minimal power consumption. We previously proposed a high-port-count optical switch architecture that utilizes tunable lasers, route-and-combine switches, and wavelength-routing switches comprised of couplers, erbium-doped fiber amplifiers (EDFAs), and AWGs. We employed conventional external cavity lasers whose wavelength-tuning speed was slower than 100 ms. In this paper, we demonstrate a large-scale optical switch that offers fast wavelength routing. We construct a 720×720 optical switch using recently developed lasers whose wavelength-tuning period is below 460 μs. We evaluate the switching time via bit-error-ratio measurements and achieve 470-μs switching time (includes 10-μs guard time to handle EDFA surge). To best of our knowledge, this is the first demonstration of such a large-scale optical switch with practical switching time.

Bacterial Fe(II) oxidation distinguished by long-range correlation in redox potential

NASA Astrophysics Data System (ADS)

Enright, Allison M. L.; Ferris, F. Grant

2016-05-01

The kinetics of bacterial Fe(II) oxidation was investigated 297 m underground at the Äspö Hard Rock Laboratory (near Oskarshamn, Sweden) under steady state groundwater flow conditions in a flow-through cell containing well-developed flocculent mats of bacteriogenic iron oxides (BIOS). Pseudo first-order rate constants of 0.004 min-1 and 0.009 min-1 were obtained for chemical and bacterial Fe(II) oxidation, respectively, based on the 104 min retention time of groundwater in the flow cell, inlet Fe(II) concentration of 21.0 ± 0.5 µm, outlet Fe(II) concentration of 8.5 ± 0.7 µm, as well as constant pH = - log H+ of 7.42 ± 0.01, dissolved O2 concentration of 0.11 ± 0.01 mg/L, and groundwater temperature of 12.4 ± 0.1°C. Redox potential was lower at the BIOS-free inlet (-135.4 ± 1.16 mV) compared to inside BIOS within the flow cell (-112.6 ± 1.91 mV), consistent with the Nernst relationship and oxidation of Fe(II) to Fe(III). Further evaluation of the redox potential time series data using detrended fluctuation analysis (DFA) revealed power law scaling in the amplitude of fluctuations over increasing intervals of time with significantly different (p < 0.01) DFA α scaling exponents of 1.89 ± 0.03 for BIOS and 1.67 ± 0.06 at the inlet. These α values not only signal the presence of long-range correlation in the redox potential time series measurements but also distinguish between the slower rate of chemical Fe(II) oxidation at the inlet and faster rate accelerated by FeOB in BIOS.

Semantic Effects in Naming Perceptual Identification but Not in Delayed Naming: Implications for Models and Tasks

ERIC Educational Resources Information Center

Wurm, Lee H.; Seaman, Sean R.

2008-01-01

Previous research has demonstrated that the subjective danger and usefulness of words affect lexical decision times. Usually, an interaction is found: Increasing danger predicts faster reaction times (RTs) for words low on usefulness, but increasing danger predicts slower RTs for words high on usefulness. The authors show the same interaction with…

Age and Sex Differences in Intra-Individual Variability in a Simple Reaction Time Task

ERIC Educational Resources Information Center

Ghisletta, Paolo; Renaud, Olivier; Fagot, Delphine; Lecerf, Thierry; de Ribaupierre, Anik

2018-01-01

While age effects in reaction time (RT) tasks across the lifespan are well established for level of performance, analogous findings have started appearing also for indicators of intra-individual variability (IIV). Children are not only slower, but also display more variability than younger adults in RT. Yet, little is known about potential…

Cognitive performance and BMI in childhood: Shared genetic influences between reaction time but not response inhibition

USDA-ARS?s Scientific Manuscript database

The aim of this work is to understand whether shared genetic influences can explain the associationbetween obesity and cognitive performance, including slower and more variable reaction times(RTs) and worse response inhibition. RT on a four-choice RT task and the go/no-go task, and commission errors...

Coupled CaAl-NaSi diffusion in plagioclase feldspar: Experiments and applications to cooling rate speedometry

NASA Astrophysics Data System (ADS)

Grove, Timothy L.; Baker, Michael B.; Kinzler, Rosamond J.

1984-10-01

The rate of CaAl-NaSi interdiffusion in plagioclase feldspar was determined under 1 atm anhydrous conditions over the temperature range 1400° to 1000°C in calcic plagioclase (An 80-81) by homogenizing coherent exsolution lamellae. The dependence of the average interdiffusion coefficient on temperature is given by the expression: D˜ = 10.99 ( cm 2/sec) exp (-123.4( kcal/mol)/RT), (T in °K). This value is for diffusion perpendicular to the (03 1¯) interface of the lamellae. CaAl-NaSi interdiffusion is 4 to 5 orders of magnitude slower than oxygen diffusion in the temperature range 1400° to 1200°C and possibly 10 orders of magnitude slower at subsolidus temperatures. The large differences in diffusion rates explain the apparent contradiction posed by the plagioclases of large layered intrusions ( e.g., the Skaergaard), which retain delicate Ca, Na compositional zoning profiles on the micron scale, but have undergone complete oxygen isotopic exchange with heated meteoric groundwater from the surrounding wall rocks. CaAl-NaSi diffusion is slow, the closure temperature is high (within the solidus-liquidus interval), and Ca-Na zoning is preserved. Oxygen diffusion is faster, the closure temperature is lower (350°-400°C) and the feldspars exchange oxygen with the low-temperature hydrothermal fluids. The complex micron-scale oscillatory zones in plagioclase can also be used as cooling rate speedometers for volcanic and plutonic plagioclase. Cooling histories typical of large mafic intrusions ( e.g. the Stillwater) are slow, begin at high initial temperatures (1200°C) and result in homogenization of oscillatory zones on the scale of 10 microns. The oscillatory zones found in the plagioclase of granodioritic plutons are preserved because cooling is initiated at a lower temperature (1000°C) limiting diffusion to submicron length scales despite the slow cooling rate of the intrusion.

Turbulent entrainment in a strongly stratified barrier layer

NASA Astrophysics Data System (ADS)

Pham, H. T.; Sarkar, S.

2017-06-01

Large-eddy simulation (LES) is used to investigate how turbulence in the wind-driven ocean mixed layer erodes the stratification of barrier layers. The model consists of a stratified Ekman layer that is driven by a surface wind. Simulations at a wide range of N0/f are performed to quantify the effect of turbulence and stratification on the entrainment rate. Here, N0 is the buoyancy frequency in the barrier layer and f is the Coriolis parameter. The evolution of the mixed layer follows two stages: a rapid initial deepening and a late-time growth at a considerably slower rate. During the first stage, the mixed layer thickens to the depth that is proportional to u∗/fN0 where u∗ is the frictional velocity. During the second stage, the turbulence in the mixed layer continues to deepen further into the barrier layer, and the turbulent length scale is shown to scale with u∗/N0, independent of f. The late-time entrainment rate E follows the law of E=0.035Ri∗-1/2 where Ri∗ is the Richardson number. The exponent of -1/2 is identical but the coefficient of 0.035 is much smaller relative to the value of 2-3/2 for the nonrotating boundary layer. Simulations using the KPP model (version applicable to this simple case without additional effects of Langmuir turbulence or surface buoyancy flux) also yield the entrainment scaling of E∝Ri∗-1/2; however, the proportionality coefficient varies with the stratification. The structure of the Ekman current is examined to illustrate the strong effect of stratification in the limit of large N0/f.

Mechanical Determinants of Faster Change of Direction Speed Performance in Male Athletes.

PubMed

DosʼSantos, Thomas; Thomas, Christopher; Jones, Paul A; Comfort, Paul

2017-03-01

Dos'Santos, T, Thomas, C, Jones, PA, and Comfort, P. Mechanical determinants of faster change of direction speed performance in male athletes. J Strength Cond Res 31(3): 696-705, 2017-Mechanical variables during change of directions, for example, braking and propulsive forces, impulses, and ground contact times (GCT) have been identified as determinants of faster change of direction speed (CODS) performance. The purpose of this study was to investigate the mechanical determinants of 180° CODS performance with mechanical characteristic comparisons between faster and slower performers; while exploring the role of the penultimate foot contact (PEN) during the change of direction. Forty multidirectional male athletes performed 6 modified 505 (mod505) trials (3 left and right), and ground reaction forces were collected across the PEN and final foot contact (FINAL) during the change of direction. Pearson's correlation coefficients and coefficients of determination were used to explore the relationship between mechanical variables and mod505 completion time. Independent T-tests and Cohen's d effect sizes (ES) were conducted between faster (n = 10) and slower (n = 10) mod505 performers to explore differences in mechanical variables. Faster CODS performance was associated (p ≤ 0.05) with shorter GCTs (r = 0.701-0.757), greater horizontal propulsive forces (HPF) (r = -0.572 to -0.611), greater horizontal braking forces (HBF) in the PEN (r = -0.337), lower HBF ratios (r = -0.429), and lower FINAL vertical impact forces (VIF) (r = 0.449-0.559). Faster athletes demonstrated significantly (p ≤ 0.05, ES = 1.08-2.54) shorter FINAL GCTs, produced lower VIF, lower HBF ratios, and greater HPF in comparison to slower athletes. These findings suggest that different mechanical properties are required to produce faster CODS performance, with differences in mechanical properties observed between fast and slower performers. Furthermore, applying a greater proportion of braking force during the PEN relative to the FINAL may be advantageous for turning performance.

29 CFR 70.25 - Time limits and order in which requests must be processed.

Code of Federal Regulations, 2012 CFR

2012-07-01

... pages involved. If a component does so, it will advise requesters in its slower track(s) of the limits... unrelated matters will not be aggregated. (d) Expedited processing. (1) Requests and appeals will be taken...

29 CFR 70.25 - Time limits and order in which requests must be processed.

Code of Federal Regulations, 2011 CFR

2011-07-01

... pages involved. If a component does so, it will advise requesters in its slower track(s) of the limits... unrelated matters will not be aggregated. (d) Expedited processing. (1) Requests and appeals will be taken...

29 CFR 70.25 - Time limits and order in which requests must be processed.

Code of Federal Regulations, 2013 CFR

2013-07-01

... pages involved. If a component does so, it will advise requesters in its slower track(s) of the limits... unrelated matters will not be aggregated. (d) Expedited processing. (1) Requests and appeals will be taken...

Miles Hand Grenade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrington, John J.; Buttz, James H.; Maish, Alex B.

2005-11-15

A simulated grenade for MILES-type simulations generates a unique RF signal and a unique audio signal. A detector utilizes the time between receipt of the RF signal and the slower-traveling audio signal to determine the distance between the detector and the simulated grenade.

Effects of autonomic ganglion blockade on fractal and spectral components of blood pressure and heart rate variability in free-moving rats.

PubMed

Castiglioni, Paolo; Di Rienzo, Marco; Radaelli, Alberto

2013-11-01

Fractal analysis is a promising tool for assessing autonomic influences on heart rate (HR) and blood pressure (BP) variability. The temporal spectrum of scale coefficients, α(t), was recently proposed to describe the cardiovascular fractal dynamics. Aim of our work is to evaluate sympathetic influences on cardiovascular variability analyzing α(t) and spectral powers of HR and BP after ganglionic blockade. BP was recorded in 11 rats before and after autonomic blockade by hexamethonium infusion (HEX). Systolic and diastolic BP, pulse pressure and pulse interval were derived beat-by-beat. Segments longer than 5 min were selected at baseline and HEX to estimate power spectra and α(t). Comparisons were made by paired t-test. HEX reduced all spectral components of systolic and diastolic BP, the reduction being particularly significant around the frequency of Mayer waves; it induced a reduction on α(t) coefficients at t<2s and an increase on coefficients at t>8s. HEX reduced only slower components of pulse interval power spectrum, but decreased significantly faster scale coefficients (t<8s). HEX only marginally affected pulse pressure variability. Results indicate that the sympathetic outflow contributes to BP fractal dynamics with fractional Gaussian noise (α<1) at longer scales and fractional Brownian motion (α>1) at shorter scales. Ganglionic blockade also removes a fractional Brownian motion component at shorter scales from HR dynamics. Results may be explained by the characteristic time constants between sympathetic efferent activity and cardiovascular effectors. Therefore fractal analysis may complete spectral analysis with information on the correlation structure of the data. Copyright © 2013 Elsevier B.V. All rights reserved.

Age-related differences in the motor planning of a lower leg target matching task.

PubMed

Davies, Brenda L; Gehringer, James E; Kurz, Max J

2015-12-01

While the development and execution of upper extremity motor plans have been well explored, little is known about how individuals plan and execute rapid, goal-directed motor tasks with the lower extremities. Furthermore, the amount of time needed to integrate the proper amount of visual and proprioceptive feedback before being able to accurately execute a goal-directed movement is not well understood; especially in children. Therefore, the purpose of this study was to initially interrogate how the amount of motor planning time provided to a child before movement execution may influence the preparation and execution of a lower leg goal-directed movement. The results displayed that the amount of pre-movement motor planning time provided may influence the reaction time and accuracy of a goal directed leg movement. All subjects in the study had longer reaction times and less accurate movements when no pre-movement motor planning time was provided. In addition, the children had slower reaction times, slower movements, and less accurate movements than the adults for all the presented targets and motor planning times. These results highlight that children may require more time to successfully plan a goal directed movement with the lower extremity. This suggests that children may potentially have less robust internal models than adults for these types of motor skills. Copyright © 2015 Elsevier B.V. All rights reserved.

Mapping the core mass function to the initial mass function

NASA Astrophysics Data System (ADS)

Guszejnov, Dávid; Hopkins, Philip F.

2015-07-01

It has been shown that fragmentation within self-gravitating, turbulent molecular clouds (`turbulent fragmentation') can naturally explain the observed properties of protostellar cores, including the core mass function (CMF). Here, we extend recently developed analytic models for turbulent fragmentation to follow the time-dependent hierarchical fragmentation of self-gravitating cores, until they reach effectively infinite density (and form stars). We show that turbulent fragmentation robustly predicts two key features of the initial mass function (IMF). First, a high-mass power-law scaling very close to the Salpeter slope, which is a generic consequence of the scale-free nature of turbulence and self-gravity. We predict the IMF slope (-2.3) is slightly steeper than the CMF slope (-2.1), owing to the slower collapse and easier fragmentation of large cores. Secondly, a turnover mass, which is set by a combination of the CMF turnover mass (a couple solar masses, determined by the `sonic scale' of galactic turbulence, and so weakly dependent on galaxy properties), and the equation of state (EOS). A `soft' EOS with polytropic index γ < 1.0 predicts that the IMF slope becomes `shallow' below the sonic scale, but fails to produce the full turnover observed. An EOS, which becomes `stiff' at sufficiently low surface densities Σgas ˜ 5000 M⊙ pc-2, and/or models, where each collapsing core is able to heat and effectively stiffen the EOS of a modest mass (˜0.02 M⊙) of surrounding gas, are able to reproduce the observed turnover. Such features are likely a consequence of more detailed chemistry and radiative feedback.

Photochemical oxidation and changes in molecular composition of organic aerosol in the regional context

NASA Astrophysics Data System (ADS)

Robinson, Allen L.; Donahue, Neil M.; Rogge, Wolfgang F.

2006-02-01

This paper presents evidence that condensed-phase organic compounds are significantly oxidized in regional air masses and in locations affected by regional transport, especially during the summer. The core of the paper examines a large data set of ambient organic aerosol concentrations for removal of reactive compounds relative to less-reactive compounds. The approach allows visualization of both photochemistry and mixing of emissions from multiple sources in order to differentiate between the two phenomena. The focus is on hopanes and alkenoic acids, important markers for motor vehicle and cooking emissions. Ambient data from Pittsburgh, PA and the Southeastern United States contain evidence for significant photochemical oxidation of these compounds in the summertime. There is a strong seasonal pattern in the ratio of different hopanes to elemental carbon consistent with oxidation. In addition, measurements at rural sites indicate that hopanes are severely depleted in the regional air mass during the summer. Alkenoic acids also appear to be photochemically oxidized during the summertime; however, the oxidation rate appears to be much slower than that inferred from laboratory experiments. The significance of photochemistry is supported by rudimentary calculations which indicate substantial oxidation by OH radicals and ozone on a time scale of a few days or so, comparable to time scales for regional transport. Oxidation is non-linear; therefore it represents a very substantial complication to linear source apportionment techniques such as the Chemical Mass Balance model.

Impact of Spatial Neglect in Stroke Rehabilitation: Evidence from the Setting of an Inpatient Rehabilitation Facility

PubMed Central

Chen, Peii; Hreha, Kimberly; Kong, Yekyung; Barrett, A. M.

2015-01-01

Objective To examine the impact of spatial neglect on rehabilitation outcome, risk of falls, and discharge disposition in stroke survivors. Design Inception cohort Setting Inpatient rehabilitation facility (IRF) Participants 108 individuals with unilateral brain damage after their first stroke were assessed at the times of IRF admission and discharge. At admission, 74 of them (68.5%) demonstrated symptoms of spatial neglect, as measured with the Kessler Foundation Neglect Assessment Process (KF-NAP™). Interventions Usual and standard IRF care. Main Outcome Measures Functional Independence Measure (FIM™), Conley Scale, number of falls, length of stay (LOS), and discharge disposition. Results The greater severity of spatial neglect (higher KF-NAP scores) at IRF admission, the lower FIM scores at admission as well as at discharge. Higher KF-NAP scores also correlated with greater LOS and slower FIM improvement rate. The presence of spatial neglect (KF-NAP > 0), but not Conley Scale scores, predicted falls such that participants with spatial neglect fell 6.5 times more often than those without symptoms. More severe neglect, by KF-NAP scores at IRF admission, reduced the likelihood of returning home at discharge. A model that took spatial neglect and other demographic, socioeconomic, and clinical factors into account predicted home discharge. Rapid FIM improvement during IRF stay and lower annual income level were significant predictors of home discharge. Conclusions Spatial neglect following a stroke is a prevalent problem, and may negatively affect rehabilitation outcome, risk of falls, and length of hospital stay. PMID:25862254

Do Activity Level Outcome Measures Commonly Used in Neurological Practice Assess Upper-Limb Movement Quality?

PubMed

Demers, Marika; Levin, Mindy F

2017-07-01

Movement is described in terms of task-related end point characteristics in external space and movement quality (joint rotations in body space). Assessment of upper-limb (UL) movement quality can assist therapists in designing effective treatment approaches for retraining lost motor elements and provide more detailed measurements of UL motor improvements over time. To determine the extent to which current activity level outcome measures used in neurological practice assess UL movement quality. Outcome measures assessing arm/hand function at the International Classification of Function activity level recommended by neurological clinical practice guidelines were reviewed. Measures assessing the UL as part of a general mobility assessment, those strictly evaluating body function/structure or participation, and paediatric measures were excluded. In all, 15 activity level outcome measures were identified; 9 measures assess how movement is performed by measuring either end point characteristics or movement quality. However, except for the Reaching Performance Scale for Stroke and the Motor Evaluation Scale for Upper Extremity in Stroke Patients, these measures only account for deficits indirectly by giving a partial score if movements are slower or if the person experiences difficulties. Six outcome measures neither assess any parameters related to movement quality, nor distinguish between improvements resulting from motor compensation or recovery of desired movement strategies. Current activity measures may not distinguish recovery from compensation and adequately track changes in movement quality over time. Movement quality may be incorporated into clinical assessment using observational kinematics with or without low-cost motion tracking technology.

Wet disc contraction to galactic blue nuggets and quenching to red nuggets

NASA Astrophysics Data System (ADS)

Dekel, A.; Burkert, A.

2014-02-01

We study the origin of high-redshift, compact, quenched spheroids (red nuggets) through the dissipative shrinkage of gaseous discs into compact star-forming systems (blue nuggets). The discs, fed by cold streams, undergo violent disc instability that drives gas into the centre (along with mergers). The inflow is dissipative when its time-scale is shorter than the star formation time-scale. This implies a threshold of ˜0.28 in the cold-to-total mass ratio within the disc radius. For the typical gas fraction ˜0.5 at z ˜ 2, this threshold is traced back to a maximum spin parameter of ˜0.05, implying that ˜half the star-forming galaxies contract to blue nuggets, while the rest form extended stellar discs. Thus, the surface density of blue galaxies is expected to be bimodal about ˜109 M⊙ kpc-2, slightly increasing with mass. The blue nuggets are expected to be rare at low z when the gas fraction is low. The blue nuggets quench to red nuggets by complementary internal and external mechanisms. Internal quenching by a compact bulge, in a fast mode and especially at high z, may involve starbursts, stellar and active galactic nucleus feedback, or Q-quenching. Quenching due to hot-medium haloes above 1012 M⊙ provides maintenance and a slower mode at low redshift. These predictions are confirmed in simulations and are consistent with observations at z = 0-3.

Distributional analyses in the picture-word interference paradigm: Exploring the semantic interference and the distractor frequency effects.

PubMed

Scaltritti, Michele; Navarrete, Eduardo; Peressotti, Francesca

2015-01-01

The present study explores the distributional features of two important effects within the picture-word interference paradigm: the semantic interference and the distractor frequency effects. These two effects display different and specific distributional profiles. Semantic interference appears greatly reduced in faster response times, while it reaches its full magnitude only in slower responses. This can be interpreted as a sign of fluctuant attentional efficiency in resolving response conflict. In contrast, the distractor frequency effect is mediated mainly by a distributional shift, with low-frequency distractors uniformly shifting reaction time distribution towards a slower range of latencies. This finding fits with the idea that distractor frequency exerts its effect by modulating the point in time in which operations required to discard the distractor can start. Taken together, these results are congruent with current theoretical accounts of both the semantic interference and distractor frequency effects. Critically, distributional analyses highlight and further describe the different cognitive dynamics underlying these two effects, suggesting that this analytical tool is able to offer important insights about lexical access during speech production.

Nucleation versus percolation: Scaling criterion for failure in disordered solids

NASA Astrophysics Data System (ADS)

Biswas, Soumyajyoti; Roy, Subhadeep; Ray, Purusattam

2015-05-01

One of the major factors governing the mode of failure in disordered solids is the effective range R over which the stress field is modified following a local rupture event. In a random fiber bundle model, considered as a prototype of disordered solids, we show that the failure mode is nucleation dominated in the large system size limit, as long as R scales slower than Lζ, with ζ =2 /3 . For a faster increase in R , the failure properties are dominated by the mean-field critical point, where the damages are uncorrelated in space. In that limit, the precursory avalanches of all sizes are obtained even in the large system size limit. We expect these results to be valid for systems with finite (normalizable) disorder.

A versatile dual-species Zeeman slower for caesium and ytterbium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, S. A., E-mail: s.a.hopkins@durham.ac.uk; Butler, K.; Guttridge, A.

2016-04-15

We describe the design, construction, and operation of a versatile dual-species Zeeman slower for both Cs and Yb, which is easily adaptable for use with other alkali metals and alkaline earths. With the aid of analytic models and numerical simulation of decelerator action, we highlight several real-world problems affecting the performance of a slower and discuss effective solutions. To capture Yb into a magneto-optical trap (MOT), we use the broad {sup 1}S{sub 0} to {sup 1}P{sub 1} transition at 399 nm for the slower and the narrow {sup 1}S{sub 0} to {sup 3}P{sub 1} intercombination line at 556 nm formore » the MOT. The Cs MOT and slower both use the D2 line (6{sup 2}S{sub 1/2} to 6{sup 2}P{sub 3/2}) at 852 nm. The slower can be switched between loading Yb or Cs in under 0.1 s. We demonstrate that within a few seconds the Zeeman slower loads more than 10{sup 9} Yb atoms and 10{sup 8} Cs atoms into their respective MOTs. These are ideal starting numbers for further experiments on ultracold mixtures and molecules.« less

Affective Priming with Associatively Acquired Valence

ERIC Educational Resources Information Center

Aguado, Luis; Pierna, Manuel; Saugar, Cristina

2005-01-01

Three experiments explored the effect of affectively congruent or incongruent primes on evaluation responses to positive or negative valenced targets (the "affective priming" effect). Experiment 1 replicated the basic affective priming effect with Spanish nouns: reaction time for evaluative responses (pleasant/unpleasant) were slower on…

Developmental Relations between Perceived Social Support and Depressive Symptoms through Emerging Adulthood: Blood is Thicker than Water

PubMed Central

Pettit, Jeremy W.; Roberts, Robert E.; Lewinsohn, Peter M.; Seeley, John R.; Yaroslavsky, Ilya

2010-01-01

Longitudinal trajectories of depressive symptoms, perceived support from family, and perceived support from friends were examined among 816 emerging adults (480 women; 59%). In the context of a larger longitudinal investigation on the predictors and course of depression, data were drawn from eight self-report questionnaire assessments that roughly spanned the third decade of life. An age-based scaling approach was used to model trajectories of depressive symptoms and perceived social support between the ages of 21 and 30. Associative models of the relations between depressive symptoms and perceived social support from family and friends were tested. Results indicated that depressive symptoms decreased and perceived social support increased during the study period. Associative models suggested that among women, higher initial levels of perceived support from family predicted slower decreases in depressive symptoms (b = .34, p < .01). Among men, higher initial levels of depressive symptoms predicted slower increases in perceived family support (b = −.23, p < .05). Cross-domain predictive effects were not observed for perceived support from friends and depressive symptoms. Implications of the findings are discussed. PMID:21355652

A Diffusion Model Analysis of the Effects of Aging on Recognition Memory

ERIC Educational Resources Information Center

Ratcliff, Roger; Thapar, Anjali; McKoon, Gail

2004-01-01

The effects of aging on response time were examined in a recognition memory experiment with young, college age subjects and older, 60-75 year old subjects. The older subjects were slower than the young subjects but almost as accurate. Ratcliff's (1978) diffusion model was fit to the data and it provided a good account of response times, their…

Pacing profiles of senior men and women at the 2017 IAAF World Cross Country Championships.

PubMed

Hanley, Brian

2018-06-01

The purpose of this study was to analyse and compare pacing profiles of senior men and women competing in the 2017 World Cross Country Championships. Finishing and split times were collated for 118 men and 81 women competing over the newly introduced race distance of 10 km (five laps of approximately 2 km). Athletes were grouped according to finishing time, and changes in pace measured using lap times, except between Laps 1 and 2 because of a shorter first lap (times relative to the winner were used instead). Within both men's and women's races, groups slowed during the early stages, but then either sped up or maintained pace during the last lap. There were few differences between groups with regard to overall pacing profiles, or between sexes. The men's fast finish contrasted with slower finishes found in previous editions (over 12 km), and the degree to which women were slower than men (approximately 12%) was very similar to track racing and showed the decision to equalise the distances run by both sexes was sound. As in other distance events, athletes are recommended to try to achieve an even pace throughout, an approach that proved beneficial to both gold medallists.

Survival of Salmonella typhimurium and Escherichia coli O157:H7 in poultry manure and manure slurry at sublethal temperatures.

PubMed

Himathongkham, S; Riemann, H; Bahari, S; Nuanualsuwan, S; Kass, P; Cliver, D O

2000-01-01

Exponential inactivation was observed for Salmonella typhimurium and Escherichia coli O157:H7 in poultry manure with decimal reduction times ranging from half a day at 37 C to 1-2 wk at 4 C. There was no material difference in inactivation rates between S. typhimurium and E. coli O157:H7. Inactivation was slower in slurries made by mixing two parts of water with one part of manure; decimal reduction times (time required for 90% destruction) ranged from 1-2 days at 37 C to 6-22 wk at 4 C. Escherichia coli O157:H7 consistently exhibited slightly slower inactivation than S. typhimurium. Log decimal reduction time for both strains was a linear function of storage temperature for manure and slurries. Chemical analysis indicated that accumulation of free ammonia in poultry manure was an important factor in inactivation of the pathogens. This finding was experimentally confirmed for S. typhimurium by adding ammonia directly to peptone water or to bovine manure, which was naturally low in ammonia, and adjusting pH to achieve predetermined levels of free ammonia.

Water dynamics in small reverse micelles in two solvents: two-dimensional infrared vibrational echoes with two-dimensional background subtraction.

PubMed

Fenn, Emily E; Wong, Daryl B; Fayer, M D

2011-02-07

Water dynamics as reflected by the spectral diffusion of the water hydroxyl stretch were measured in w(0) = 2 (1.7 nm diameter) Aerosol-OT (AOT)/water reverse micelles in carbon tetrachloride and in isooctane solvents using ultrafast 2D IR vibrational echo spectroscopy. Orientational relaxation and population relaxation are observed for w(0) = 2, 4, and 7.5 in both solvents using IR pump-probe measurements. It is found that the pump-probe observables are sensitive to w(0), but not to the solvent. However, initial analysis of the vibrational echo data from the water nanopool in the reverse micelles in the isooctane solvent seems to yield different dynamics than the CCl(4) system in spite of the fact that the spectra, vibrational lifetimes, and orientational relaxation are the same in the two systems. It is found that there are beat patterns in the interferograms with isooctane as the solvent. The beats are observed from a signal generated by the AOT/isooctane system even when there is no water in the system. A beat subtraction data processing procedure does a reasonable job of removing the distortions in the isooctane data, showing that the reverse micelle dynamics are the same within experimental error regardless of whether isooctane or carbon tetrachloride is used as the organic phase. Two time scales are observed in the vibrational echo data, ~1 and ~10 ps. The slower component contains a significant amount of the total inhomogeneous broadening. Physical arguments indicate that there is a much slower component of spectral diffusion that is too slow to observe within the experimental window, which is limited by the OD stretch vibrational lifetime.

Water dynamics in small reverse micelles in two solvents: Two-dimensional infrared vibrational echoes with two-dimensional background subtraction

NASA Astrophysics Data System (ADS)

Fenn, Emily E.; Wong, Daryl B.; Fayer, M. D.

2011-02-01

Water dynamics as reflected by the spectral diffusion of the water hydroxyl stretch were measured in w0 = 2 (1.7 nm diameter) Aerosol-OT (AOT)/water reverse micelles in carbon tetrachloride and in isooctane solvents using ultrafast 2D IR vibrational echo spectroscopy. Orientational relaxation and population relaxation are observed for w0 = 2, 4, and 7.5 in both solvents using IR pump-probe measurements. It is found that the pump-probe observables are sensitive to w0, but not to the solvent. However, initial analysis of the vibrational echo data from the water nanopool in the reverse micelles in the isooctane solvent seems to yield different dynamics than the CCl4 system in spite of the fact that the spectra, vibrational lifetimes, and orientational relaxation are the same in the two systems. It is found that there are beat patterns in the interferograms with isooctane as the solvent. The beats are observed from a signal generated by the AOT/isooctane system even when there is no water in the system. A beat subtraction data processing procedure does a reasonable job of removing the distortions in the isooctane data, showing that the reverse micelle dynamics are the same within experimental error regardless of whether isooctane or carbon tetrachloride is used as the organic phase. Two time scales are observed in the vibrational echo data, ~1 and ~10 ps. The slower component contains a significant amount of the total inhomogeneous broadening. Physical arguments indicate that there is a much slower component of spectral diffusion that is too slow to observe within the experimental window, which is limited by the OD stretch vibrational lifetime.

Assessing denitrification in groundwater using natural gradient tracer tests with 15N: In situ measurement of a sequential multistep reaction

USGS Publications Warehouse

Smith, Richard L.; Böhlke, John Karl; Garabedian, Stephen P.; Revesz, Kinga M.; Yoshinari, Tadashi

2004-01-01

Denitrification was measured within a nitrate‐contaminated aquifer on Cape Cod, Massachusetts, using natural gradient tracer tests with 15N nitrate. The aquifer contained zones of relatively high concentrations of nitrite (up to 77 μM) and nitrous oxide (up to 143 μM) and has been the site of previous studies examining ground water denitrification using the acetylene block technique. Small‐scale (15–24 m travel distance) tracer tests were conducted by injecting 15N nitrate and bromide as tracers into a depth interval that contained nitrate, nitrite, nitrous oxide, and excess nitrogen gas. The timing of the bromide breakthrough curves at down‐gradient wells matched peaks in 15N abundance above background for nitrate, nitrite, nitrous oxide, and nitrogen gas after more than 40 days of travel. Results were simulated with a one‐dimensional transport model using linked reaction kinetics for the individual steps of the denitrification reaction pathway. It was necessary to include within the model spatial variations in background concentrations of all nitrogen oxide species. The model indicated that nitrite production (0.036–0.047 μmol N (L aquifer)−1 d−1) was faster than the subsequent denitrification steps (0.013–0.016 μmol N (L aquifer)−1 d−1 for nitrous oxide and 0.013–0.020 μmol N (L aquifer)−1 d−1 for nitrogen gas) and that the total rate of reaction was slower than indicated by both acetylene block tracer tests and laboratory incubations. The rate of nitrate removal by denitrification was much slower than the rate of transport, indicating that nitrate would migrate several kilometers down‐gradient before being completely consumed.

Ultraviolet continuum variability and visual flickering in the peculiar object MWC 560

NASA Technical Reports Server (NTRS)

Michalitsianos, A. G.; Perez, M.; Shore, S. N.; Maran, S. P.; Karovska, M.; Sonneborn, G.; Webb, J. R.; Barnes, Thomas G., III; Frueh, Marian L.; Oliversen, R. J.

1993-01-01

High-speed U-band photometry of the peculiar emission object MWC 560 obtained with the ground-based instrumentation, and V-band photometry obtained with the International Ultraviolet Explorer-Fine Error Sensor indicates irregular brightness variations are quasi-periodic. Multiple peaks of relative brightness power indicate statistically significant quasi periods existing in a range of 3-35 minutes, that are superposed on slower hourly varying components. We present a preliminary model that explains the minute and hourly time-scale variations in MWC 560 in terms of a velocity-shear instability that arises because a white dwarf magnetosphere impinges on an accretion disk. We also find evidence for Fe II multiplet pseudocontinuum absorption opacity in far-UV spectra of CH Cygni which is also present in MWC 560. Both CH Cyg and MWC 560 may be in an evolutionary stage that is characterized by strong UV continuum opacity which changes significantly during outburst, occurring before they permanently enter the symbiotic nebular emission phase.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glynos, Emmanouil; Johnson, Kyle J.; Frieberg, Bradley

Here, the surface relaxation dynamics of supported star-shaped polymer thin films are shown to be slower than the bulk, persisting up to temperatures at least 50 degrees above the bulk glass transition temperature Tmore » $$bulk\\atop{g}$$. This behavior, exhibited by star-shaped polystyrenes (SPSs) with functionality f = 8 arms and molecular weights per arm M arm < M e (M e is the entanglement molecular weight), is shown by molecular dynamics simulations to be associated with a preferential localization of these macromolecules at the free surface. This new phenomenon is in notable contrast to that of linear chain polymer thin film systems where the surface relaxations are enhanced in relation to the bulk; this enhancement persists only for a limited temperature range above the bulk T$$bulk\\atop{g}$$. Finally, evidence of the slow surface dynamics, compared to the bulk, for temperatures well above T g and at length and time scales not associated with the glass transition has not previously been reported for polymers.« less

The optical and radiation field signatures produced by lightning return strokes

NASA Technical Reports Server (NTRS)

Guo, C.; Krider, E. P.

1982-01-01

Typical examples of the signals that are produced by first and subsequent return strokes in cloud-to-ground lightning on a microsecond time scale are presented. Statistics on the structure of the waveforms and the radiance of the channels are given. The relationship between the light signals and the associated electric field signatures is discussed. It is shown that the initial light signal from a return stroke tends to be linear for about 15 microsec and then rises more slowly to a peak that is delayed by approximately 60 microsec from the electric field peak. It is thought that the transition between the fast linear portion and the slower rise may be due to the return stroke entering the cloud base. A small percentage of the records suggest that two different branches of the same stepped leader can initiate separate return strokes. The light pulses from cloud discharges tend to be smaller and to vary more slowly than those from return strokes.

An Explanation of the Missing Flux from Boyajian's Mysterious Star

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foukal, Peter

A previously unremarkable star in the constellation Cygnus has, in the past year, become known as the most mysterious object in our Galaxy. Boyajian’s star exhibits puzzling episodes of sporadic, deep dimming discovered in photometry with the Kepler Mission. Proposed explanations have focused on its obscuration by colliding exoplanets, exocomets, and even intervention of alien intelligence. These hypotheses have considered only phenomena external to the star because the radiative flux missing in the dimmings was believed to exceed the star’s storage capacity. We point out that modeling of variations in solar luminosity indicates that convective stars can store the requiredmore » fluxes. It also suggests explanations for (a) a reported time-profile asymmetry of the short, deep dimmings and (b) a slower, decadal scale dimming reported from archival and Kepler photometry. Our findings suggest a broader range of explanations of Boyajian’s star that may produce new insights into stellar magneto-convection.« less

Free Surface Relaxations of Star-Shaped Polymer Films

DOE PAGES

Glynos, Emmanouil; Johnson, Kyle J.; Frieberg, Bradley; ...

2017-11-28

Here, the surface relaxation dynamics of supported star-shaped polymer thin films are shown to be slower than the bulk, persisting up to temperatures at least 50 degrees above the bulk glass transition temperature Tmore » $$bulk\\atop{g}$$. This behavior, exhibited by star-shaped polystyrenes (SPSs) with functionality f = 8 arms and molecular weights per arm M arm < M e (M e is the entanglement molecular weight), is shown by molecular dynamics simulations to be associated with a preferential localization of these macromolecules at the free surface. This new phenomenon is in notable contrast to that of linear chain polymer thin film systems where the surface relaxations are enhanced in relation to the bulk; this enhancement persists only for a limited temperature range above the bulk T$$bulk\\atop{g}$$. Finally, evidence of the slow surface dynamics, compared to the bulk, for temperatures well above T g and at length and time scales not associated with the glass transition has not previously been reported for polymers.« less

Transient photoresponse in amorphous In-Ga-Zn-O thin films under stretched exponential analysis

NASA Astrophysics Data System (ADS)

Luo, Jiajun; Adler, Alexander U.; Mason, Thomas O.; Bruce Buchholz, D.; Chang, R. P. H.; Grayson, M.

2013-04-01

We investigated transient photoresponse and Hall effect in amorphous In-Ga-Zn-O thin films and observed a stretched exponential response which allows characterization of the activation energy spectrum with only three fit parameters. Measurements of as-grown films and 350 K annealed films were conducted at room temperature by recording conductivity, carrier density, and mobility over day-long time scales, both under illumination and in the dark. Hall measurements verify approximately constant mobility, even as the photoinduced carrier density changes by orders of magnitude. The transient photoconductivity data fit well to a stretched exponential during both illumination and dark relaxation, but with slower response in the dark. The inverse Laplace transforms of these stretched exponentials yield the density of activation energies responsible for transient photoconductivity. An empirical equation is introduced, which determines the linewidth of the activation energy band from the stretched exponential parameter β. Dry annealing at 350 K is observed to slow the transient photoresponse.

Nonequilibrium Kondo effect in a magnetic field: auxiliary master equation approach

NASA Astrophysics Data System (ADS)

Fugger, Delia M.; Dorda, Antonius; Schwarz, Frauke; von Delft, Jan; Arrigoni, Enrico

2018-01-01

We study the single-impurity Anderson model out of equilibrium under the influence of a bias voltage ϕ and a magnetic field B. We investigate the interplay between the shift ({ω }B) of the Kondo peak in the spin-resolved density of states (DOS) and the one ({φ }B) of the conductance anomaly. In agreement with experiments and previous theoretical calculations we find that, while the latter displays a rather linear behavior with an almost constant slope as a function of B down to the Kondo scale, the DOS shift first features a slower increase reaching the same behavior as {φ }B only for | g| {μ }BB\\gg {k}B{T}K. Our auxiliary master equation approach yields highly accurate nonequilibrium results for the DOS and for the conductance all the way from within the Kondo up to the charge fluctuation regime, showing excellent agreement with a recently introduced scheme based on a combination of numerical renormalization group with time-dependent density matrix renormalization group.

Parallel electron force balance and the L-H transition

DOE PAGES

Stoltzfus-Dueck, T.

2016-05-23

In one popular paradigm for the L-H transition, energy transfer to the mean flows directly depletes turbulence fluctuation energy, resulting in suppression of the turbulence and a corresponding transport bifurcation. To quantitatively evaluate this mechanism, one must remember that electron parallel force balance couples nonzonal velocity fluctuations with electron pressure fluctuations on rapid timescales, comparable with the electron transit time. For this reason, energy in the nonzonal velocity stays in a fairly fixed ratio to the free energy in electron density fluctuations, at least for frequency scales much slower than electron transit. Furthermore, in order for direct depletion of themore » energy in turbulent fluctuations to cause the L-H transition, energy transfer via Reynolds stress must therefore drain enough energy to significantly reduce the sum of the free energy in nonzonal velocities and electron pressure fluctuations. At low k⊥, the electron thermal free energy is much larger than the energy in nonzonal velocities, posing a stark challenge for this model of the L-H transition.« less

Mesolimbic Dopamine Signals the Value of Work

PubMed Central

Hamid, Arif A.; Pettibone, Jeffrey R.; Mabrouk, Omar S.; Hetrick, Vaughn L.; Schmidt, Robert; Vander Weele, Caitlin M.; Kennedy, Robert T.; Aragona, Brandon J.; Berke, Joshua D.

2015-01-01

Dopamine cell firing can encode errors in reward prediction, providing a learning signal to guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating current behavior. Existing theories propose that fast (“phasic”) dopamine fluctuations support learning, while much slower (“tonic”) dopamine changes are involved in motivation. We examined dopamine release in the nucleus accumbens across multiple time scales, using complementary microdialysis and voltammetric methods during adaptive decision-making. We first show that minute-by-minute dopamine levels covary with reward rate and motivational vigor. We then show that second-by-second dopamine release encodes an estimate of temporally-discounted future reward (a value function). We demonstrate that changing dopamine immediately alters willingness to work, and reinforces preceding action choices by encoding temporal-difference reward prediction errors. Our results indicate that dopamine conveys a single, rapidly-evolving decision variable, the available reward for investment of effort, that is employed for both learning and motivational functions. PMID:26595651

Studies of molecular diffusion in single-supported bilayer lipid membranes at high hydration by quasielastic neutron scattering

NASA Astrophysics Data System (ADS)

Bai, M.; Miskowiec, A.; Wang, S.-K.; Taub, H.; Hansen, F. Y.; Jenkins, T.; Tyagi, M.; Neumann, D. A.; Diallo, S. O.; Mamontov, E.; Herwig, K. W.

2011-03-01

Bilayer lipid membranes supported on a solid surface are attractive model systems for understanding the structure and dynamics of more complex biological membranes that form the outer boundary of living cells. We have recently obtained quasielastic neutron spectra from single-supported bilayer lipid membranes using the backscattering spectrometer BASIS at the Spallation Neutron Source. Protonated DMPC membranes were deposited onto Si O2 -coated Si(100) substrates and characterized by AFM. Analysis of their neutron spectra shows evidence of a relatively broad Lorentzian component that we associate with bulk-like water above a freezing temperature of ~ 267 K. At lower temperatures, the spectra differ qualitatively from that of bulk supercooled water, a behavior that we attribute to water bound to the membrane. We also find evidence of a narrow Lorentzian component that we tentatively identify with a slower motion (time scale ~ 1 ns) associated with conformational changes of the alkyl tails of the lipid molecules. Supported by NSF Grant No. DMR-0705974.

Glasslike Membrane Protein Diffusion in a Crowded Membrane.

PubMed

Munguira, Ignacio; Casuso, Ignacio; Takahashi, Hirohide; Rico, Felix; Miyagi, Atsushi; Chami, Mohamed; Scheuring, Simon

2016-02-23

Many functions of the plasma membrane depend critically on its structure and dynamics. Observation of anomalous diffusion in vivo and in vitro using fluorescence microscopy and single particle tracking has advanced our concept of the membrane from a homogeneous fluid bilayer with freely diffusing proteins to a highly organized crowded and clustered mosaic of lipids and proteins. Unfortunately, anomalous diffusion could not be related to local molecular details given the lack of direct and unlabeled molecular observation capabilities. Here, we use high-speed atomic force microscopy and a novel analysis methodology to analyze the pore forming protein lysenin in a highly crowded environment and document coexistence of several diffusion regimes within one membrane. We show the formation of local glassy phases, where proteins are trapped in neighbor-formed cages for time scales up to 10 s, which had not been previously experimentally reported for biological membranes. Furthermore, around solid-like patches and immobile molecules a slower glass phase is detected leading to protein trapping and creating a perimeter of decreased membrane diffusion.

Non-radiative relaxation of photoexcited chlorophylls: Theoretical and experimental study

DOE PAGES

Bricker, William P.; Shenai, Prathamesh M.; Ghosh, Avishek; ...

2015-09-08

Nonradiative relaxation of high-energy excited states to the lowest excited state in chlorophylls marks the first step in the process of photosynthesis. We perform ultrafast transient absorption spectroscopy measurements, that reveal this internal conversion dynamics to be slightly slower in chlorophyll B than in chlorophyll A. With modeling this process, non-adiabatic excited state molecular dynamics simulations uncovers a critical role played by the different side groups in the two molecules in governing the intramolecular redistribution of excited state wavefunction, leading, in turn, to different time-scales. Even given smaller electron-vibrational couplings compared to common organic conjugated chromophores, these molecules are ablemore » to efficiently dissipate about 1 eV of electronic energy into heat on the timescale of around 200 fs. This is achieved via selective participation of specific atomic groups and complex global migration of the wavefunction from the outer to inner ring, which may have important implications for biological light-harvesting function.« less

Biological causal links on physiological and evolutionary time scales.

PubMed

Karmon, Amit; Pilpel, Yitzhak

2016-04-26

Correlation does not imply causation. If two variables, say A and B, are correlated, it could be because A causes B, or that B causes A, or because a third factor affects them both. We suggest that in many cases in biology, the causal link might be bi-directional: A causes B through a fast-acting physiological process, while B causes A through a slowly accumulating evolutionary process. Furthermore, many trained biologists tend to consistently focus at first on the fast-acting direction, and overlook the slower process in the opposite direction. We analyse several examples from modern biology that demonstrate this bias (codon usage optimality and gene expression, gene duplication and genetic dispensability, stem cell division and cancer risk, and the microbiome and host metabolism) and also discuss an example from linguistics. These examples demonstrate mutual effects between the fast physiological processes and the slow evolutionary ones. We believe that building awareness of inference biases among biologists who tend to prefer one causal direction over another could improve scientific reasoning.

Robust Brain-Machine Interface Design Using Optimal Feedback Control Modeling and Adaptive Point Process Filtering

PubMed Central

Carmena, Jose M.

2016-01-01

Much progress has been made in brain-machine interfaces (BMI) using decoders such as Kalman filters and finding their parameters with closed-loop decoder adaptation (CLDA). However, current decoders do not model the spikes directly, and hence may limit the processing time-scale of BMI control and adaptation. Moreover, while specialized CLDA techniques for intention estimation and assisted training exist, a unified and systematic CLDA framework that generalizes across different setups is lacking. Here we develop a novel closed-loop BMI training architecture that allows for processing, control, and adaptation using spike events, enables robust control and extends to various tasks. Moreover, we develop a unified control-theoretic CLDA framework within which intention estimation, assisted training, and adaptation are performed. The architecture incorporates an infinite-horizon optimal feedback-control (OFC) model of the brain’s behavior in closed-loop BMI control, and a point process model of spikes. The OFC model infers the user’s motor intention during CLDA—a process termed intention estimation. OFC is also used to design an autonomous and dynamic assisted training technique. The point process model allows for neural processing, control and decoder adaptation with every spike event and at a faster time-scale than current decoders; it also enables dynamic spike-event-based parameter adaptation unlike current CLDA methods that use batch-based adaptation on much slower adaptation time-scales. We conducted closed-loop experiments in a non-human primate over tens of days to dissociate the effects of these novel CLDA components. The OFC intention estimation improved BMI performance compared with current intention estimation techniques. OFC assisted training allowed the subject to consistently achieve proficient control. Spike-event-based adaptation resulted in faster and more consistent performance convergence compared with batch-based methods, and was robust to parameter initialization. Finally, the architecture extended control to tasks beyond those used for CLDA training. These results have significant implications towards the development of clinically-viable neuroprosthetics. PMID:27035820

Effects of turbulent hyporheic mixing on reach-scale solute transport

NASA Astrophysics Data System (ADS)

Roche, K. R.; Li, A.; Packman, A. I.

2017-12-01

Turbulence rapidly mixes solutes and fine particles into coarse-grained streambeds. Both hyporheic exchange rates and spatial variability of hyporheic mixing are known to be controlled by turbulence, but it is unclear how turbulent mixing influences mass transport at the scale of stream reaches. We used a process-based particle-tracking model to simulate local- and reach-scale solute transport for a coarse-bed stream. Two vertical mixing profiles, one with a smooth transition from in-stream to hyporheic transport conditions and a second with enhanced turbulent transport at the sediment-water interface, were fit to steady-state subsurface concentration profiles observed in laboratory experiments. The mixing profile with enhanced interfacial transport better matched the observed concentration profiles and overall mass retention in the streambed. The best-fit mixing profiles were then used to simulate upscaled solute transport in a stream. Enhanced mixing coupled in-stream and hyporheic solute transport, causing solutes exchanged into the shallow subsurface to have travel times similar to the water column. This extended the exponential region of the in-stream solute breakthrough curve, and delayed the onset of the heavy power-law tailing induced by deeper and slower hyporheic porewater velocities. Slopes of observed power-law tails were greater than those predicted from stochastic transport theory, and also changed in time. In addition, rapid hyporheic transport velocities truncated the hyporheic residence time distribution by causing mass to exit the stream reach via subsurface advection, yielding strong exponential tempering in the in-stream breakthrough curves at the timescale of advective hyporheic transport through the reach. These results show that strong turbulent mixing across the sediment-water interface violates the conventional separation of surface and subsurface flows used in current models for solute transport in rivers. Instead, the full distribution of flow and mixing over the surface-subsurface continuum must be explicitly considered to properly interpret solute transport in coarse-bed streams.

Theory and simulation of ion noise in microwave tubes

NASA Astrophysics Data System (ADS)

Manheimer, W. M.; Freund, H. P.; Levush, B.; Antonsen, T. M.

2001-01-01

Since there is always some ambient gas in electron beam devices, background ionization is ubiquitous. For long pulse times, the electrostatic potentials associated with this ionization can reach significant levels and give rise to such observed phenomena as phase noise in microwave tubes. This noise is usually associated with the motion of ions in the device; therefore, it is called ion noise. It often manifests itself as a slow phase fluctuation on the output signal. Observations of noise in microwave tubes such as coupled-cavity traveling wave tubes (CC-TWTs) and klystrons have been discussed in the literature. In this paper, a hybrid model is discussed in which the electron beam is described by the beam envelope equation, and the ions generated by beam ionization are treated as discrete particles using the one-dimensional equations of motion. The theoretical model provides good qualitative as well as reasonable quantitative insight into the origin of ion noise phenomena. The numerical results indicate that the model reproduces the salient features of the phase oscillations observed experimentally. That is, the scaling of the frequency of the phase oscillations with gas pressure in the device and the sensitive dependence of the phase oscillations on the focusing magnetic field. Two distinct time scales are observed in simulation. The fastest time scale oscillation is related to the bounce motion of ions in the axial potential wells formed by the scalloping of the electron beam. Slower sawtooth oscillations are observed to correlate with the well-to-well interactions induced by the ion coupling to the electron equilibrium. These oscillations are also correlated with ion dumping to the cathode or collector. As a practical matter, simulations indicate that the low frequency oscillations can be reduced significantly by using a well-matched electron beam propagating from the electron gun into the interaction circuit.

Millennial-Scale Temperature Change Velocity in the Continental Northern Neotropics

PubMed Central

Correa-Metrio, Alexander; Bush, Mark; Lozano-García, Socorro; Sosa-Nájera, Susana

2013-01-01

Climate has been inherently linked to global diversity patterns, and yet no empirical data are available to put modern climate change into a millennial-scale context. High tropical species diversity has been linked to slow rates of climate change during the Quaternary, an assumption that lacks an empirical foundation. Thus, there is the need for quantifying the velocity at which the bioclimatic space changed during the Quaternary in the tropics. Here we present rates of climate change for the late Pleistocene and Holocene from Mexico and Guatemala. An extensive modern pollen survey and fossil pollen data from two long sedimentary records (30,000 and 86,000 years for highlands and lowlands, respectively) were used to estimate past temperatures. Derived temperature profiles show a parallel long-term trend and a similar cooling during the Last Glacial Maximum in the Guatemalan lowlands and the Mexican highlands. Temperature estimates and digital elevation models were used to calculate the velocity of isotherm displacement (temperature change velocity) for the time period contained in each record. Our analyses showed that temperature change velocities in Mesoamerica during the late Quaternary were at least four times slower than values reported for the last 50 years, but also at least twice as fast as those obtained from recent models. Our data demonstrate that, given extremely high temperature change velocities, species survival must have relied on either microrefugial populations or persistence of suppressed individuals. Contrary to the usual expectation of stable climates being associated with high diversity, our results suggest that Quaternary tropical diversity was probably maintained by centennial-scale oscillatory climatic variability that forestalled competitive exclusion. As humans have simplified modern landscapes, thereby removing potential microrefugia, and climate change is occurring monotonically at a very high velocity, extinction risk for tropical species is higher than at any time in the last 86,000 years. PMID:24312614

Millennial-scale temperature change velocity in the continental northern Neotropics.

PubMed

Correa-Metrio, Alexander; Bush, Mark; Lozano-García, Socorro; Sosa-Nájera, Susana

2013-01-01

Climate has been inherently linked to global diversity patterns, and yet no empirical data are available to put modern climate change into a millennial-scale context. High tropical species diversity has been linked to slow rates of climate change during the Quaternary, an assumption that lacks an empirical foundation. Thus, there is the need for quantifying the velocity at which the bioclimatic space changed during the Quaternary in the tropics. Here we present rates of climate change for the late Pleistocene and Holocene from Mexico and Guatemala. An extensive modern pollen survey and fossil pollen data from two long sedimentary records (30,000 and 86,000 years for highlands and lowlands, respectively) were used to estimate past temperatures. Derived temperature profiles show a parallel long-term trend and a similar cooling during the Last Glacial Maximum in the Guatemalan lowlands and the Mexican highlands. Temperature estimates and digital elevation models were used to calculate the velocity of isotherm displacement (temperature change velocity) for the time period contained in each record. Our analyses showed that temperature change velocities in Mesoamerica during the late Quaternary were at least four times slower than values reported for the last 50 years, but also at least twice as fast as those obtained from recent models. Our data demonstrate that, given extremely high temperature change velocities, species survival must have relied on either microrefugial populations or persistence of suppressed individuals. Contrary to the usual expectation of stable climates being associated with high diversity, our results suggest that Quaternary tropical diversity was probably maintained by centennial-scale oscillatory climatic variability that forestalled competitive exclusion. As humans have simplified modern landscapes, thereby removing potential microrefugia, and climate change is occurring monotonically at a very high velocity, extinction risk for tropical species is higher than at any time in the last 86,000 years.

What can numerical simulations say about Jupiter’s deep, long-lived anticyclones?

NASA Astrophysics Data System (ADS)

Chan, Kwing L.

2017-10-01

If Jupiter’s long-lived anticyclones, GRS being the most prominent example, are indeed deep as indicated, the study of their dynamics would be much more difficult than if they were shallow. A shallow phenomenon limited to the troposphere can be modeled by general circulation models like those used in weather prediction for Earth’s atmosphere, as the layer overall is convectively stable (hydrostatic approximation can be applied) and the time scales (advection and radiation) are relatively short. If the dynamics involve the deep convective envelop below, the time scales for thermal relaxation and spin-up would be many orders of magnitudes longer. At the same time, the requirements for handling stratification, turbulence, compressibility, fast rotation, spatial resolution, and numerical stability conditions are not forgiving. Currently, numerical studies of long-lived vortices generated in convection zone are limited to ‘numerical experiments’ having internal energy fluxes many orders of magnitudes greater than that of Jupiter (for faster thermal and dynamical relaxation). Though these experiments cannot predict quantitative values for direct observational comparison, their information on the spatial distributions and connections among velocity, temperature, pressure etc. can tell a lot about what a deep-seated model can predict or describe. We are going to present the results of our latest fully compressible, large-eddy-simulation model for generation of long-lived anticyclones in deep convection zone. The high turbulence and complex internal structures of the vortices can naturally be explained. One prediction for observation is: While fluctuations of temperature and vertical velocity dissipate relative fast with height in the troposphere (stable region), the horizontal velocities (vortical motions) drop much slower; they hardly decrease by a factor of two in four pressure scale heights in the overshoot region. Acknowledgement: This research is supported by FDCT of Macau 039/2013/A2 and 080/2015/A3.

Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 compared to their susceptibilities to 11 other agents.

PubMed

Credito, K L; Lin, G; Pankuch, G A; Bajaksouzian, S; Jacobs, M R; Appelbaum, P C

2001-01-01

The activity of the ketolide ABT-773 against Haemophilus and Moraxella was compared to those of 11 other agents. Against 210 Haemophilus influenzae strains (39.0% beta-lactamase positive), microbroth dilution tests showed that azithromycin and ABT-773 had the lowest MICs (0.5 to 4.0 and 1.0 to 8.0 microg/ml, respectively), followed by clarithromycin and roxithromycin (4.0 to >32.0 microg/ml). Of the beta-lactams, ceftriaxone had the lowest MICs (32.0 microg/ml). Against 50 Moraxella catarrhalis strains, all of the compounds except amoxicillin and cefprozil were active. Time-kill studies against 10 H. influenzae strains showed that ABT-773, at two times the MIC, was bactericidal against 9 of 10 strains, with 99% killing of all strains at the MIC after 24 h; at 12 h, ABT-773 gave 90% killing of all strains at two times the MIC. At 3 and 6 h, killing by ABT-773 was slower, with 99.9% killing of four strains at two times the MIC after 6 h. Similar results were found for azithromycin, with slightly slower killing by erythromycin, clarithromycin, and roxithromycin, especially at earlier times. beta-Lactams were bactericidal against 8 to 10 strains at two times the MIC after 24 h, with slower killing at earlier time periods. Most compounds gave good killing of five M. catarrhalis strains, with beta-lactams killing more rapidly than other drugs. ABT-773 and azithromycin gave the longest postantibiotic effects (PAEs) of the ketolide-macrolide-azalide group tested (4.4 to >8.0 h), followed by clarithromycin, erythromycin, and roxithromycin. beta-Lactam PAEs were similar and shorter than those of the ketolide-macrolide-azalide group for all strains tested.

Performance evaluation of several commercial alloys in a reducing environment

NASA Astrophysics Data System (ADS)

Liu, Y.

Several commercial alloys including Ebrite, Crofer 22 APU, Haynes 230 and Haynes 242, which are candidates for intermediate-temperature solid oxide fuel cell (SOFC) interconnect materials, were isothermally and cyclically oxidized at 900 °C in the reducing atmosphere of Ar + 5 vol.% H 2 + 3 vol.% H 2O corresponding to the SOFC anode environment. Results indicate that these alloys exhibited good scale spallation resistance with the Ni-base alloys possessing better oxidation resistance over the Fe-base alloys. Both Mn-Cr spinel and Cr 2O 3 were formed in the oxide scales of these alloys. For Crofer 22 APU and Haynes 242, a continuous protective MnO and Mn-Cr spinel layer formed outside on the inner layer of Cr 2O 3. The increase in scale ASR after longer-term thermal exposure in the reducing environment was relatively slower for the Ni-base alloys than for the Fe-base alloys.

Phenology of mixed woody-herbaceous ecosystems following extreme events: net and differential responses.

PubMed

Rich, Paul M; Breshears, David D; White, Amanda B

2008-02-01

Ecosystem responses to key climate drivers are reflected in phenological dynamics such as the timing and degree of "green-up" that integrate responses over spatial scales from individual plants to ecosystems. This integration is clearest in ecosystems dominated by a single species or life form, such as seasonally dynamic grasslands or more temporally constant evergreen forests. Yet many ecosystems have substantial contribution of cover from both herbaceous and woody evergreen plants. Responses of mixed woody-herbaceous ecosystems to climate are of increasing concern due to their extensive nature, the potential for such systems to yield more complex responses than those dominated by a single life form, and projections that extreme climate and weather events will increase in frequency and intensity with global warming. We present responses of a mixed woody-herbaceous ecosystem type to an extreme event: regional-scale piñon pine mortality following an extended drought and the subsequent herbaceous green-up following the first wet period after the drought. This example highlights how reductions in greenness of the slower, more stable evergreen woody component can rapidly be offset by increases associated with resources made available to the relatively more responsive herbaceous component. We hypothesize that such two-phase phenological responses to extreme events are characteristic of many mixed woody-herbaceous ecosystems.

Active wound dressings based on bacterial nanocellulose as drug delivery system for octenidine.

PubMed

Moritz, Sebastian; Wiegand, Cornelia; Wesarg, Falko; Hessler, Nadine; Müller, Frank A; Kralisch, Dana; Hipler, Uta-Christina; Fischer, Dagmar

2014-08-25

Although bacterial nanocellulose (BNC) may serve as an ideal wound dressing, it exhibits no antibacterial properties by itself. Therefore, in the present study BNC was functionalized with the antiseptic drug octenidine. Drug loading and release, mechanical characteristics, biocompatibility, and antimicrobial efficacy were investigated. Octenidine release was based on diffusion and swelling according to the Ritger-Peppas equation and characterized by a time dependent biphasic release profile, with a rapid release in the first 8h, followed by a slower release rate up to 96 h. The comparison between lab-scale and up-scale BNC identified thickness, water content, and the surface area to volume ratio as parameters which have an impact on the control of the release characteristics. Compression and tensile strength remained unchanged upon incorporation of octenidine in BNC. In biological assays, drug-loaded BNC demonstrated high biocompatibility in human keratinocytes and antimicrobial activity against Staphylococcus aureus. In a long-term storage test, the octenidine loaded in BNC was found to be stable, releasable, and biologically active over a period of 6 months without changes. In conclusion, octenidine loaded BNC presents a ready-to-use wound dressing for the treatment of infected wounds that can be stored over 6 months without losing its antibacterial activity. Copyright © 2014 Elsevier B.V. All rights reserved.

Climate drives inter-annual variability in probability of high severity fire occurrence in the western United States

NASA Astrophysics Data System (ADS)

Keyser, Alisa; Westerling, Anthony LeRoy

2017-05-01

A long history of fire suppression in the western United States has significantly changed forest structure and ecological function, leading to increasingly uncharacteristic fires in terms of size and severity. Prior analyses of fire severity in California forests showed that time since last fire and fire weather conditions predicted fire severity very well, while a larger regional analysis showed that topography and climate were important predictors of high severity fire. There has not yet been a large-scale study that incorporates topography, vegetation and fire-year climate to determine regional scale high severity fire occurrence. We developed models to predict the probability of high severity fire occurrence for the western US. We predict high severity fire occurrence with some accuracy, and identify the relative importance of predictor classes in determining the probability of high severity fire. The inclusion of both vegetation and fire-year climate predictors was critical for model skill in identifying fires with high fractional fire severity. The inclusion of fire-year climate variables allows this model to forecast inter-annual variability in areas at future risk of high severity fire, beyond what slower-changing fuel conditions alone can accomplish. This allows for more targeted land management, including resource allocation for fuels reduction treatments to decrease the risk of high severity fire.

Perceived pain, fear of falling and physical function in women with osteoporosis.

PubMed

Hübscher, Markus; Vogt, Lutz; Schmidt, Katharina; Fink, Matthias; Banzer, Winfried

2010-07-01

The aim of this cross-sectional study was to evaluate pain intensity-related differences in physical performance and fear of falling in elderly women with osteoporosis. A sample of 82 osteoporotic women (73.8±8.1 years) with and without vertebral fractures was included. Numeric rating scale (NRS) measures (0=no pain, 10=unbearable) were applied to obtain actual pain intensity and to stratify between patients with mild (0-3), moderate (4-6) and severe (7-10) pain. Activity-related fear of falling was evaluated with the Falls Efficacy Scale-International Version (FES-I). Physical performance measures included maximum voluntary quadriceps strength, postural sway and gait speed measures. Controlling for age, fractures, and history of falls ANCOVA with Scheffe's post hoc test indicated significant slower walking velocities and greater postural sway for patients with severe pain. Furthermore, significant group differences could be detected for muscle strength and fear of falling. Patients with more intense pain (NRS≥5) were 6.4 times (odds ratio; 95%CI: 1.5-26.7) more likely to score below average in fall-related self-efficacy and all physical performance tests. Among women with osteoporosis, heightened back pain intensity increases fear of falling and decreases physical performance irrespective of vertebral fractures and history of falls. Copyright © 2010 Elsevier B.V. All rights reserved.

Slower postnatal motor development in infants of mothers with latent toxoplasmosis during the first 18 months of life.

PubMed

Kaňková, Sárka; Sulc, Jan; Křivohlavá, Romana; Kuběna, Aleš; Flegr, Jaroslav

2012-11-01

Toxoplasmosis, a zoonosis caused by a protozoan, Toxoplasma gondii, is probably the most widespread human parasitosis in developed countries. Pregnant women with latent toxoplasmosis have seemingly younger fetuses especially in the 16th week of gestation, which suggests that fetuses of Toxoplasma-infected mothers have slower rates of development in the first trimester of pregnancy. In the present retrospective cohort study, we analyzed data on postnatal motor development of infants from 331 questionnaire respondents including 53 Toxoplasma-infected mothers to search for signs of early postnatal development disorders. During the first year of life, a slower postnatal motor development was observed in infants of mothers with latent toxoplasmosis. These infants significantly later developed the ability to control the head position (p=0.039), to roll from supine to prone position (p=0.022) and were slightly later to begin crawling (p=0.059). Our results are compatible with the hypothesis that the difference in the rates of prenatal and early postnatal development between children of Toxoplasma-negative and Toxoplasma-positive mothers might be caused by a decreased stringency of embryo quality control in partly immunosuppressed Toxoplasma-positive mothers resulting in a higher proportion of infants with genetic or developmental disorders in offspring. However, because of relatively low return rate of questionnaires and an associated risk of a sieve effect, our results should be considered as preliminary and performing a large scale prospective study in the future is critically needed. Copyright © 2012 Elsevier Ltd. All rights reserved.

Designing and building a permanent magnet Zeeman slower for calcium atoms using a 3D printer

NASA Astrophysics Data System (ADS)

Parsagian, Alexandria; Kleinert, Michaela

2015-10-01

We present the design of a Zeeman slower for calcium atoms using permanent magnets instead of more traditional electromagnets and the novel technique of 3D printing to create a very robust and flexible structure for these magnets. Zeeman slowers are ideal tools to slow atoms from several hundreds of meters per second to just a few tens of meters per second. These slower atoms can then easily be trapped in a magneto-optical trap, making Zeeman slowers a very valuable tool in many cold atom labs. The use of permanent magnets and 3D printing results in a highly stable and robust slower that is suitable for undergraduate laboratories. In our design, we arranged 28 magnet pairs, 2.0 cm apart along the axis of the slower and at varying radial distances from the axis. We determined the radial position of the magnets by simulating the combined field of all magnet pairs using Mathematica and comparing it to the ideal theoretical field for a Zeeman slower. Finally, we designed a stable, robust, compact, and easy-to-align mounting structure for the magnets in Google Sketchup, which we then printed using a commercially available 3D printer by Solidoodle. The resulting magnetic field is well suited to slow calcium atoms from the 770 m/s rms velocity at a temperature of 950 K, down to the capture velocity of the magneto-optical trap.

Comparing the Impact of Refractive and Non-Refractive Vision Loss on Functioning and Disability: The Salisbury Eye Evaluation

PubMed Central

Zebardast, Nazlee; Swenor, Bonnielin K.; van Landingham, Suzanne W.; Massof, Robert W.; Munoz, Beatriz; West, Sheila K.; Ramulu, Pradeep Y.

2015-01-01

Purpose To compare the effects of uncorrected refractive error (URE) and non-refractive visual impairment (VI) on performance and disability measures. Design Cross-sectional population-based study. Participants 2469 individuals with binocular presenting visual acuity (PVA) of 20/80 or better who participated in the first round of the Salisbury Eye Evaluation study. Methods URE was defined as binocular PVA of 20/30 or worse, improving to better than 20/30 with subjective refraction. VI was defined as post-refraction binocular best corrected visual acuity (BCVA) of 20/30 or worse. The visual acuity decrement attributable to VI was calculated as the difference between BCVA and 20/30 while that due to URE was taken as the difference between PVA and BCVA. Multivariable regression analyses were used to assess the disability impact of 1) vision status (VI, URE, or normal vision) using the group with normal vision as reference, and 2) a one-line decrement in acuity due to VI or URE. Main Outcome Measures Objective measures of visual function were obtained from timed performance of mobility and near vision tasks, self-reported driving cessation, and self-reported visual difficulty measured by the Activities of Daily Vision (ADV) scale. ADV responses were analyzed using Rasch analysis to determine visual ability. Results Compared to individuals with normal vision, subjects with VI (n=191) had significantly poorer objective and subjective visual functioning in all metrics examined (p<0.05) while subjects with URE (n=132) demonstrated slower walking speeds, slower near task performance, more frequent driving cessation and lower ADV scores (p<0.05), but did not demonstrate slower stair climbing or descent speed. For all functional metrics evaluated, the impact of VI was greater than the impact of URE. The impact of a one-line VA decrement due to VI was associated with greater deficits in mobility measures and driving cessation when compared to a one-line VA decrement due to URE. Conclusions VI is associated with greater disability than URE across a wide variety of functional measures, even in analyses adjusting for the severity of vision loss. Refractive and non-refractive vision loss should be distinguished in studies evaluating visual disability, and should be understood to have differing consequences. PMID:25813453

Eruption of a plasma blob, associated M-class flare, and large-scale extreme-ultraviolet wave observed by SDO

NASA Astrophysics Data System (ADS)

Kumar, P.; Manoharan, P. K.

2013-05-01

We present a multiwavelength study of the formation and ejection of a plasma blob and associated extreme ultraviolet (EUV) waves in active region (AR) NOAA 11176, observed by SDO/AIA and STEREO on 25 March 2011. The EUV images observed with the AIA instrument clearly show the formation and ejection of a plasma blob from the lower atmosphere of the Sun at ~9 min prior to the onset of the M1.0 flare. This onset of the M-class flare happened at the site of the blob formation, while the blob was rising in a parabolic path with an average speed of ~300 km s. The blob also showed twisting and de-twisting motion in the lower corona, and the blob speed varied from ~10-540 km s. The faster and slower EUV wavefronts were observed in front of the plasma blob during its impulsive acceleration phase. The faster EUV wave propagated with a speed of ~785 to 1020 km s, whereas the slower wavefront speed varied in between ~245 and 465 km s. The timing and speed of the faster wave match the shock speed estimated from the drift rate of the associated type II radio burst. The faster wave experiences a reflection by the nearby AR NOAA 11177. In addition, secondary waves were observed (only in the 171 Å channel), when the primary fast wave and plasma blob impacted the funnel-shaped coronal loops. The Helioseismic Magnetic Imager (HMI) magnetograms revealed the continuous emergence of new magnetic flux along with shear flows at the site of the blob formation. It is inferred that the emergence of twisted magnetic fields in the form of arch-filaments/"anemone-type" loops is the likely cause for the plasma blob formation and associated eruption along with the triggering of M-class flare. Furthermore, the faster EUV wave formed ahead of the blob shows the signature of fast-mode MHD wave, whereas the slower wave seems to be generated by the field line compression by the plasma blob. The secondary wave trains originated from the funnel-shaped loops are probably the fast magnetoacoustic waves. Three movies are available in electronic form at http://www.aanda.org

Comparing the Impact of Refractive and Nonrefractive Vision Loss on Functioning and Disability: The Salisbury Eye Evaluation.

PubMed

Zebardast, Nazlee; Swenor, Bonnielin K; van Landingham, Suzanne W; Massof, Robert W; Munoz, Beatriz; West, Sheila K; Ramulu, Pradeep Y

2015-06-01

To compare the effects of uncorrected refractive error (URE) and nonrefractive visual impairment (VI) on performance and disability measures. Cross-sectional, population-based study. A total of 2469 individuals with binocular presenting visual acuity (PVA) of ≥ 20/80 who participated in the first round of the Salisbury Eye Evaluation study. The URE was defined as binocular PVA of ≤ 20/30, improving to >20/30 with subjective refraction. The VI was defined as post-refraction binocular best-corrected visual acuity (BCVA) of ≤ 20/30. The visual acuity decrement due to VI was calculated as the difference between BCVA and 20/30, whereas visual acuity due to URE was taken as the difference between PVA and BCVA. Multivariable regression analyses were used to assess the disability impact of (1) vision status (VI, URE, or normal vision) using the group with normal vision as reference and (2) a 1-line decrement in acuity due to VI or URE. Objective measures of visual function were obtained from timed performance of mobility and near vision tasks, self-reported driving cessation, and self-reported visual difficulty measured by the Activities of Daily Vision (ADV) scale. The ADV responses were analyzed using Rasch analysis to determine visual ability. Compared with individuals with normal vision, subjects with VI (n = 191) had significantly poorer objective and subjective visual functioning in all metrics examined (P < 0.05), whereas subjects with URE (n = 132) demonstrated slower walking speeds, slower near task performance, more frequent driving cessation, and lower ADV scores (P < 0.05), but did not demonstrate slower stair climbing or descent speed. For all functional metrics evaluated, the impact of VI was greater than the impact of URE. The impact of a 1-line VA decrement due to VI was associated with greater deficits in mobility measures and driving cessation when compared with a 1-line VA decrement due to URE. Visual impairment is associated with greater disability than URE across a wide variety of functional measures, even in analyses adjusting for the severity of vision loss. Refractive and nonrefractive vision loss should be distinguished in studies evaluating visual disability and be understood to have differing consequences. Copyright © 2015 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Association Between Sluggish Cognitive Tempo Symptoms and Attentional Network and Working Memory in Primary Schoolchildren.

PubMed

Camprodon-Rosanas, E; Ribas-Fitó, N; Batlle, S; Persavento, C; Alvarez-Pedrerol, M; Sunyer, J; Forns, J

2017-04-01

Few consistent data are available in relation to the cognitive and neuropsychological processes involved in sluggish cognitive tempo (SCT) symptoms. The objective of this study was to determine the association of working memory and attentional networks with SCT symptoms in primary schoolchildren. The participants were schoolchildren aged 7 to 10 years ( n = 183) from primary schools in Catalonia (Spain). All the participants completed a working memory task (n-back) and an attentional network task (ANT). Their parents completed an SCT-Child Behavior Checklist self-report and a questionnaire concerning sociodemographic variables. Teachers of the participants provided information on ADHD symptoms and learning determinants. SCT symptoms were correlated with lower scores in both the n-back and ANT. In multivariate regression analysis, SCT symptoms were associated with slower hit reaction times from the ANT. Our results suggest that SCT symptoms are associated with a neuropsychological profile that is different from the classical ADHD profile and characterized by slower reaction times.

When does Iconicity in Sign Language Matter?

PubMed Central

Baus, Cristina; Carreiras, Manuel; Emmorey, Karen

2012-01-01

We examined whether iconicity in American Sign Language (ASL) enhances translation performance for new learners and proficient signers. Fifteen hearing nonsigners and 15 proficient ASL-English bilinguals performed a translation recognition task and a production translation task. Nonsigners were taught 28 ASL verbs (14 iconic; 14 non-iconic) prior to performing these tasks. Only new learners benefited from sign iconicity, recognizing iconic translations faster and more accurately and exhibiting faster forward (English-ASL) and backward (ASL-English) translation times for iconic signs. In contrast, proficient ASL-English bilinguals exhibited slower recognition and translation times for iconic signs. We suggest iconicity aids memorization in the early stages of adult sign language learning, but for fluent L2 signers, iconicity interacts with other variables that slow translation (specifically, the iconic signs had more translation equivalents than the non-iconic signs). Iconicity may also have slowed translation performance by forcing conceptual mediation for iconic signs, which is slower than translating via direct lexical links. PMID:23543899

Degradation and aggregation of delta sleep-inducing peptide (DSIP) and two analogs in plasma and serum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graf, M.V.; Saegesser, B.; Schoenenberger, G.A.

1987-07-01

The biostability of DSIP (delta sleep-inducing peptide) and two analogs in blood was investigated in order to determine if rates of inactivation contribute to variable effects in vivo. Incubation of DSIP in human or rat blood led to release of products having retention times on a gel filtration column equivalent to Trp. Formation of products was dependent on temperature, time, and species. Incubation of /sup 125/I-N-Tyr-DSIP and /sup 125/I-N-Tyr-P-DSIP, a phosphorylated analog, revealed slower degradation and, in contrast to DSIP, produced complex formation. An excess of unlabeled material did not displace the radioactivity supporting the assumption of non-specific binding/aggregation. Itmore » was concluded that the rapid disappearance of injected DSIP in blood was due to degradation, whereas complex formation together with slower degradation resulted in longer persistence of apparently intact analogs. Whether this could explain the sometimes stronger and more consistent effects of DSIP-analogs remains to be examined.« less

Balance Training Reduces Falls Risk in Older Individuals With Type 2 Diabetes

PubMed Central

Morrison, Steven; Colberg, Sheri R.; Mariano, Mira; Parson, Henri K.; Vinik, Arthur I.

2010-01-01

OBJECTIVE This study assessed the effects of balance/strength training on falls risk and posture in older individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS Sixteen individuals with type 2 diabetes and 21 age-matched control subjects (aged 50–75 years) participated. Postural stability and falls risk was assessed before and after a 6-week exercise program. RESULTS Diabetic individuals had significantly higher falls risk score compared with control subjects. The diabetic group also exhibited evidence of mild-to-moderate neuropathy, slower reaction times, and increased postural sway. Following exercise, the diabetic group showed significant improvements in leg strength, faster reaction times, decreased sway, and, consequently, reduced falls risk. CONCLUSIONS Older individuals with diabetes had impaired balance, slower reactions, and consequently a higher falls risk than age-matched control subjects. However, all these variables improved after resistance/balance training. Together these results demonstrate that structured exercise has wide-spread positive effects on physiological function for older individuals with type 2 diabetes. PMID:20097781

Standard seasons

NASA Astrophysics Data System (ADS)

Tuller, Stanton E.

1990-09-01

A renewed interest in climatic definitions of the seasons has surfaced in recent years. However, people usually associate biological phenomena and climate with the seasons. Standard seasons, defined as the periods of the year when the climate is within specified bounds, can be delimited in terms of biological phenomena if climatic thresholds are known for the groups of interest. By focusing attention on the time variation they illustrate climatic variation from a different perspective. An example of the type of information provided by standard seasons on the regional scale is given using human thermal standard seasons in the Pacific Basin. The latitudinal control of climate is indicated by the length of the hot and cold seasons. The moderation of maritime climates is seen in the shortness and slower rate of advance and retreat of the hot and cold seasons, and the extended length of the neutral (or spring) season. Standard seasons have widespread application in indicating the times of the year favorable or unfavorable for particular populations or activities. Bioclimatologists can contribute to season definition by expanding the range of information on climate-organism interaction on which seasonal thresholds are based and may find standard seasons useful in presenting the results of many types of investigations.

Asymmetric SOL Current in Vertically Displaced Plasma

NASA Astrophysics Data System (ADS)

Cabrera, J. D.; Navratil, G. A.; Hanson, J. M.

2017-10-01

Experiments at the DIII-D tokamak demonstrate a non-monotonic relationship between measured scrape-off layer (SOL) currents and vertical displacement event (VDE) rates with SOL currents becoming largely n=1 dominant as plasma is displaced by the plasma control system (PCS) at faster rates. The DIII-D PCS is used to displace the magnetic axis 10x slower than the intrinsic growth time of similar instabilities in lower single-null plasmas. Low order (n <=2) mode decomposition is done on toroidally spaced current monitors to attain measures of asymmetry in SOL current. Normalized to peak n=0 response, a 2-4x increase is seen in peak n=1 response in plasmas displaced by the PCS versus previous VDE instabilities observed when vertical control is disabled. Previous inquiry shows VDE asymmetry characterized by SOL current fraction and geometric parameters of tokamak plasmas. We note that, of plasmas displaced by the PCS, short displacement time scales near the limit of the PCS temporal control appear to result in larger n=1/n=2 asymmetries. Work supported under USDOE Cooperative Agreement DE-FC02-04ER54698 and DE-FG02-04ER54761.

A Programming Model Performance Study Using the NAS Parallel Benchmarks

DOE PAGES

Shan, Hongzhang; Blagojević, Filip; Min, Seung-Jai; ...

2010-01-01

Harnessing the power of multicore platforms is challenging due to the additional levels of parallelism present. In this paper we use the NAS Parallel Benchmarks to study three programming models, MPI, OpenMP and PGAS to understand their performance and memory usage characteristics on current multicore architectures. To understand these characteristics we use the Integrated Performance Monitoring tool and other ways to measure communication versus computation time, as well as the fraction of the run time spent in OpenMP. The benchmarks are run on two different Cray XT5 systems and an Infiniband cluster. Our results show that in general the threemore » programming models exhibit very similar performance characteristics. In a few cases, OpenMP is significantly faster because it explicitly avoids communication. For these particular cases, we were able to re-write the UPC versions and achieve equal performance to OpenMP. Using OpenMP was also the most advantageous in terms of memory usage. Also we compare performance differences between the two Cray systems, which have quad-core and hex-core processors. We show that at scale the performance is almost always slower on the hex-core system because of increased contention for network resources.« less

Entropy information of heart rate variability and its power spectrum during day and night

NASA Astrophysics Data System (ADS)

Jin, Li; Jun, Wang

2013-07-01

Physiologic systems generate complex fluctuations in their output signals that reflect the underlying dynamics. We employed the base-scale entropy method and the power spectral analysis to study the 24 hours heart rate variability (HRV) signals. The results show that such profound circadian-, age- and pathologic-dependent changes are accompanied by changes in base-scale entropy and power spectral distribution. Moreover, the base-scale entropy changes reflect the corresponding changes in the autonomic nerve outflow. With the suppression of the vagal tone and dominance of the sympathetic tone in congestive heart failure (CHF) subjects, there is more variability in the date fluctuation mode. So the higher base-scale entropy belongs to CHF subjects. With the decrease of the sympathetic tone and the respiratory frequency (RSA) becoming more pronounced with slower breathing during sleeping, the base-scale entropy drops in CHF subjects. The HRV series of the two healthy groups have the same diurnal/nocturnal trend as the CHF series. The fluctuation dynamics trend of data in the three groups can be described as “HF effect”.

Does dynamic stability govern propulsive force generation in human walking?

PubMed Central

Browne, Michael G.

2017-01-01

Before succumbing to slower speeds, older adults may walk with a diminished push-off to prioritize stability over mobility. However, direct evidence for trade-offs between push-off intensity and balance control in human walking, independent of changes in speed, has remained elusive. As a critical first step, we conducted two experiments to investigate: (i) the independent effects of walking speed and propulsive force (FP) generation on dynamic stability in young adults, and (ii) the extent to which young adults prioritize dynamic stability in selecting their preferred combination of walking speed and FP generation. Subjects walked on a force-measuring treadmill across a range of speeds as well as at constant speeds while modulating their FP according to a visual biofeedback paradigm based on real-time force measurements. In contrast to improvements when walking slower, walking with a diminished push-off worsened dynamic stability by up to 32%. Rather, we find that young adults adopt an FP at their preferred walking speed that maximizes dynamic stability. One implication of these findings is that the onset of a diminished push-off in old age may independently contribute to poorer balance control and precipitate slower walking speeds. PMID:29291129

Does dynamic stability govern propulsive force generation in human walking?

PubMed

Browne, Michael G; Franz, Jason R

2017-11-01

Before succumbing to slower speeds, older adults may walk with a diminished push-off to prioritize stability over mobility. However, direct evidence for trade-offs between push-off intensity and balance control in human walking, independent of changes in speed, has remained elusive. As a critical first step, we conducted two experiments to investigate: (i) the independent effects of walking speed and propulsive force ( F P ) generation on dynamic stability in young adults, and (ii) the extent to which young adults prioritize dynamic stability in selecting their preferred combination of walking speed and F P generation. Subjects walked on a force-measuring treadmill across a range of speeds as well as at constant speeds while modulating their F P according to a visual biofeedback paradigm based on real-time force measurements. In contrast to improvements when walking slower, walking with a diminished push-off worsened dynamic stability by up to 32%. Rather, we find that young adults adopt an F P at their preferred walking speed that maximizes dynamic stability. One implication of these findings is that the onset of a diminished push-off in old age may independently contribute to poorer balance control and precipitate slower walking speeds.

In Vivo Analytical Performance of Nitric Oxide-Releasing Glucose Biosensors

PubMed Central

2015-01-01

The in vivo analytical performance of percutaneously implanted nitric oxide (NO)-releasing amperometric glucose biosensors was evaluated in swine for 10 d. Needle-type glucose biosensors were functionalized with NO-releasing polyurethane coatings designed to release similar total amounts of NO (3.1 μmol cm–2) for rapid (16.0 ± 4.4 h) or slower (>74.6 ± 16.6 h) durations and remain functional as outer glucose sensor membranes. Relative to controls, NO-releasing sensors were characterized with improved numerical accuracy on days 1 and 3. Furthermore, the clinical accuracy and sensitivity of rapid NO-releasing sensors were superior to control and slower NO-releasing sensors at both 1 and 3 d implantation. In contrast, the slower, extended, NO-releasing sensors were characterized by shorter sensor lag times (<4.2 min) in response to intravenous glucose tolerance tests versus burst NO-releasing and control sensors (>5.8 min) at 3, 7, and 10 d. Collectively, these results highlight the potential for NO release to enhance the analytical utility of in vivo glucose biosensors. Initial results also suggest that this analytical performance benefit is dependent on the NO-release duration. PMID:24984031

In vivo analytical performance of nitric oxide-releasing glucose biosensors.

PubMed

Soto, Robert J; Privett, Benjamin J; Schoenfisch, Mark H

2014-07-15

The in vivo analytical performance of percutaneously implanted nitric oxide (NO)-releasing amperometric glucose biosensors was evaluated in swine for 10 d. Needle-type glucose biosensors were functionalized with NO-releasing polyurethane coatings designed to release similar total amounts of NO (3.1 μmol cm(-2)) for rapid (16.0 ± 4.4 h) or slower (>74.6 ± 16.6 h) durations and remain functional as outer glucose sensor membranes. Relative to controls, NO-releasing sensors were characterized with improved numerical accuracy on days 1 and 3. Furthermore, the clinical accuracy and sensitivity of rapid NO-releasing sensors were superior to control and slower NO-releasing sensors at both 1 and 3 d implantation. In contrast, the slower, extended, NO-releasing sensors were characterized by shorter sensor lag times (<4.2 min) in response to intravenous glucose tolerance tests versus burst NO-releasing and control sensors (>5.8 min) at 3, 7, and 10 d. Collectively, these results highlight the potential for NO release to enhance the analytical utility of in vivo glucose biosensors. Initial results also suggest that this analytical performance benefit is dependent on the NO-release duration.

Dissociations of spatial congruence effects across response measures: an examination of delta plots.

PubMed

Miller, Jeff; Roüast, Nora M

2016-09-01

Spatial congruence ("Simon") effects on reaction time (RT) and response force (RF) were studied in two experiments requiring speeded choice responses to the color of a stimulus located irrelevantly to the left or right of fixation. In Experiment 1 with unimanual responses, both RT and incorrect-hand RF were sensitive to spatial congruence, and both showed larger Simon effects following a congruent trial than following an incongruent one. RT and incorrect-hand RF were dissociated in distributional (i.e., delta plot) analyses, however. As in previous studies, the Simon effect on RT was largest for the fastest responses and diminished as RT increased (i.e., decreasing delta plot). In contrast, Simon effects on RF did not decrease for slower responses; if anything, they increased slightly. In Experiment 2 participants made bimanual responses, allowing measurement of the spatial congruence effect for each trial. Responses were both faster and more forceful with the spatially congruent hand than with the spatially incongruent one, but neither of these effects decreased for slower responses. Overall, the results demonstrate that at least some motor-level effects of irrelevant spatial location persist for slower responses.

Moving Clocks Do Not Always Appear to Slow down: Don't Neglect the Doppler Effect

ERIC Educational Resources Information Center

Wang, Frank

2013-01-01

In popular accounts of the time dilation effect in Einstein's special relativity, one often encounters the statement that moving clocks run slow. For instance, in the acclaimed PBS program "NOVA," Professor Brian Greene says, "[I]f I walk toward that guy... he'll perceive my watch ticking slower." Also in his earlier piece for The New York Times,…

The Timing of Prenatal Exposure to Maternal Cortisol and Psychosocial Stress Is Associated with Human Infant Cognitive Development

ERIC Educational Resources Information Center

Davis, Elysia P.; Sandman, Curt A.

2010-01-01

The consequences of prenatal maternal stress for development were examined in 125 full-term infants at 3, 6, and 12 months of age. Maternal cortisol and psychological state were evaluated 5 times during pregnancy. Exposure to elevated concentrations of cortisol early in gestation was associated with a slower rate of development over the 1st year…

Rates of post-fire vegetation recovery and fuel accumulation as a function of burn severity and time-since-burn in four western U.S. ecosystems

USDA-ARS?s Scientific Manuscript database

Vegetation recovery and fuel accumulation rates following wildfire are useful measures of ecosystem resilience, yet few studies have quantified these variables over 10 years post-fire. Conventional wisdom is that recovery time to pre-fire condition will be slower as a function of burn severity, as i...

Aging of nickel added to soils as predicted by soil pH and time.

PubMed

Ma, Yibing; Lombi, Enzo; McLaughlin, Mike J; Oliver, Ian W; Nolan, Annette L; Oorts, Koen; Smolders, Erik

2013-08-01

Although aging processes are important in risk assessment for metals in soils, the aging of Ni added to soils has not been studied in detail. In this study, after addition of water soluble Ni to soils, the changes over time in isotopic exchangeability, total concentrations and free Ni(2+) activity in soil pore water, were investigated in 16 European soils incubated outdoors for 18 months. The results showed that after Ni addition, concentrations of Ni in soil pore water and isotopic exchangeability of Ni in soils initially decreased rapidly. This phase was followed by further decreases in the parameters measured but these occurred at slower rates. Increasing soil pH increased the rate and extent of aging reactions. Semi-mechanistic models, based on Ni precipitation/nucleation on soil surfaces and micropore diffusion, were developed and calibrated. The initial fast processes, which were attributed to precipitation/nucleation, occurred over a short time (e.g. 1h), afterwards the slow processes were most likely controlled by micropore diffusion processes. The models were validated by comparing predicted and measured Ni aging in three additional, widely differing soils aged outdoors for periods up to 15 months in different conditions. These models could be used to scale ecotoxicological data generated in short-term studies to longer aging times. Copyright © 2013 Elsevier Ltd. All rights reserved.

Smooth DNA Transport through a Narrowed Pore Geometry

PubMed Central

Carson, Spencer; Wilson, James; Aksimentiev, Aleksei; Wanunu, Meni

2014-01-01

Voltage-driven transport of double-stranded DNA through nanoscale pores holds much potential for applications in quantitative molecular biology and biotechnology, yet the microscopic details of translocation have proven to be challenging to decipher. Earlier experiments showed strong dependence of transport kinetics on pore size: fast regular transport in large pores (> 5 nm diameter), and slower yet heterogeneous transport time distributions in sub-5 nm pores, which imply a large positional uncertainty of the DNA in the pore as a function of the translocation time. In this work, we show that this anomalous transport is a result of DNA self-interaction, a phenomenon that is strictly pore-diameter dependent. We identify a regime in which DNA transport is regular, producing narrow and well-behaved dwell-time distributions that fit a simple drift-diffusion theory. Furthermore, a systematic study of the dependence of dwell time on DNA length reveals a single power-law scaling of 1.37 in the range of 35–20,000 bp. We highlight the resolution of our nanopore device by discriminating via single pulses 100 and 500 bp fragments in a mixture with >98% accuracy. When coupled to an appropriate sequence labeling method, our observation of smooth DNA translocation can pave the way for high-resolution DNA mapping and sizing applications in genomics. PMID:25418307

Fluorescence correlation spectroscopy diffusion laws in the presence of moving nanodomains

NASA Astrophysics Data System (ADS)

Šachl, Radek; Bergstrand, Jan; Widengren, Jerker; Hof, Martin

2016-03-01

It has been shown by means of simulations that spot variation fluorescence correlation spectroscopy (sv-FCS) can be used for the identification and, to some extent, also characterization of immobile lipid nanodomains in model as well as cellular plasma membranes. However, in these simulations, the nanodomains were assumed to be stationary, whereas they actually tend to move like the surrounding lipids. In the present study, we investigated how such domain movement influences the diffusion time/spot-size dependence observed in FCS experiments, usually referred to as ‘diffusion law’ analysis. We show that domain movement might mask the effects of the ‘anomalous’ diffusion characteristics of membrane lipids or proteins predicted for stationary domains, making it difficult to identify such moving nanodomains by sv-FCS. More specifically, our simulations indicate that (i) for domains moving up to a factor of 2.25 slower than the surrounding lipids, such impeded diffusion cannot be observed and the diffusion behaviour of the proteins or lipids is indistinguishable from that of freely diffusing molecules, i.e. nanodomains are not detected; (ii) impeded protein/lipid diffusion behaviour can be observed in experiments where the radii of the detection volume are similar in size to the domain radii, the domain diffusion is about 10 times slower than that of the lipids, and the probes show a high affinity to the domains; and (iii) presence of nanodomains can only be reliably detected by diffraction limited sv-FCS when the domains move very slowly (about 200 times slower than the lipid diffusion). As nanodomains are expected to be in the range of tens of nanometres and most probes show low affinities to such domains, sv-FCS is limited to stationary domains and/or STED-FCS. However, even for that latter technique, diffusing domains smaller than 50 nm in radius are hardly detectable by FCS diffusion time/spot-size dependencies.

Macroscopic kinetics of pentameric ligand gated ion channels: comparisons between two prokaryotic channels and one eukaryotic channel.

PubMed

Laha, Kurt T; Ghosh, Borna; Czajkowski, Cynthia

2013-01-01

Electrochemical signaling in the brain depends on pentameric ligand-gated ion channels (pLGICs). Recently, crystal structures of prokaryotic pLGIC homologues from Erwinia chrysanthemi (ELIC) and Gloeobacter violaceus (GLIC) in presumed closed and open channel states have been solved, which provide insight into the structural mechanisms underlying channel activation. Although structural studies involving both ELIC and GLIC have become numerous, thorough functional characterizations of these channels are still needed to establish a reliable foundation for comparing kinetic properties. Here, we examined the kinetics of ELIC and GLIC current activation, desensitization, and deactivation and compared them to the GABAA receptor, a prototypic eukaryotic pLGIC. Outside-out patch-clamp recordings were performed with HEK-293T cells expressing ELIC, GLIC, or α1β2γ2L GABAA receptors, and ultra-fast ligand application was used. In response to saturating agonist concentrations, we found both ELIC and GLIC current activation were two to three orders of magnitude slower than GABAA receptor current activation. The prokaryotic channels also had slower current desensitization on a timescale of seconds. ELIC and GLIC current deactivation following 25 s pulses of agonist (cysteamine and pH 4.0 buffer, respectively) were relatively fast with time constants of 24.9 ± 5.1 ms and 1.2 ± 0.2 ms, respectively. Surprisingly, ELIC currents evoked by GABA activated very slowly with a time constant of 1.3 ± 0.3 s and deactivated even slower with a time constant of 4.6 ± 1.2 s. We conclude that the prokaryotic pLGICs undergo similar agonist-mediated gating transitions to open and desensitized states as eukaryotic pLGICs, supporting their use as experimental models. Their uncharacteristic slow activation, slow desensitization and rapid deactivation time courses are likely due to differences in specific structural elements, whose future identification may help uncover mechanisms underlying pLGIC gating transitions.

Scalability of Parallel Spatial Direct Numerical Simulations on Intel Hypercube and IBM SP1 and SP2

NASA Technical Reports Server (NTRS)

Joslin, Ronald D.; Hanebutte, Ulf R.; Zubair, Mohammad

1995-01-01

The implementation and performance of a parallel spatial direct numerical simulation (PSDNS) approach on the Intel iPSC/860 hypercube and IBM SP1 and SP2 parallel computers is documented. Spatially evolving disturbances associated with the laminar-to-turbulent transition in boundary-layer flows are computed with the PSDNS code. The feasibility of using the PSDNS to perform transition studies on these computers is examined. The results indicate that PSDNS approach can effectively be parallelized on a distributed-memory parallel machine by remapping the distributed data structure during the course of the calculation. Scalability information is provided to estimate computational costs to match the actual costs relative to changes in the number of grid points. By increasing the number of processors, slower than linear speedups are achieved with optimized (machine-dependent library) routines. This slower than linear speedup results because the computational cost is dominated by FFT routine, which yields less than ideal speedups. By using appropriate compile options and optimized library routines on the SP1, the serial code achieves 52-56 M ops on a single node of the SP1 (45 percent of theoretical peak performance). The actual performance of the PSDNS code on the SP1 is evaluated with a "real world" simulation that consists of 1.7 million grid points. One time step of this simulation is calculated on eight nodes of the SP1 in the same time as required by a Cray Y/MP supercomputer. For the same simulation, 32-nodes of the SP1 and SP2 are required to reach the performance of a Cray C-90. A 32 node SP1 (SP2) configuration is 2.9 (4.6) times faster than a Cray Y/MP for this simulation, while the hypercube is roughly 2 times slower than the Y/MP for this application. KEY WORDS: Spatial direct numerical simulations; incompressible viscous flows; spectral methods; finite differences; parallel computing.

Radiolytic formation of the carbon dioxide radical anion in acetonitrile revealed by transient IR spectroscopy

DOE PAGES

Grills, David Charles; Lymar, Sergei

2018-03-29

In this study, the solvated electron in CH 3CN is scavenged by CO 2 with a rate constant of 3.2 × 10 10 M –1 s –1 to produce the carbon dioxide radical anion (CO 2 •–), a strong and versatile reductant. Using pulse radiolysis with time-resolved IR detection, this radical is unambiguously identified by its absorption band at 1650 cm –1 corresponding to the antisymmetric CO 2 •– stretch. This assignment is confirmed by 13C isotopic labelling experiments and DFT calculations. In neat CH 3CN, CO 2 •– decays on a ~10 μs time scale via recombination with solvent-derivedmore » radicals (R•) and solvated protons. Upon addition of formate (HCO 2 –), the radiation yield of CO 2 •– is substantially increased due to H-atom abstraction by R• from HCO 2 – (R• + HCO 2 – → RH + CO 2 •–), which occurs in two kinetically separated steps. The rapid step involves the stronger H-abstracting CN•, CH 3•, and possibly, H• primary radicals, while the slower step is due to the less reactive, but more abundant radical, CH 2CN•. The removal of solvent radicals by HCO 2 – also results in over a hundredfold increase in the CO 2 •– lifetime. CO 2 •– scavenging experiments suggest that at 50 mM HCO 2 –, about 60% of the solvent-derived radicals are engaged in CO 2 •– generation. Finally, even under CO 2 saturation, no formation of the radical adduct, (CO 2) 2 •–, could be detected on the microsecond time scale.« less

Urban Landscape Spatial Pattern Estimation of Cities in Shandong Province Using Nighttime Luminosity Data

NASA Astrophysics Data System (ADS)

Fan, J.; He, H.; Hu, T.; Li, G.; Gao, H.; Zhao, X.

2017-09-01

China's cities have been undergoing rapid and intense urbanization processes in the past few decades. Shandong is a coastal province which is located in East China with big economy and population scales, and which also plays an important role in the rapid process of China's modernization. The DMSP/OLS dataset has been widely used for the urban development assessments in long time-series and large spatial scales situations. In this paper, we used a time series of nighttime light data to estimate the landscape spatial pattern changes of cities in Shandong province from 1994 to 2012. Nine landscape metrics were calculated and analyzed to figure out the spatial patterns of urban area developments of the cities in Shandong province. The landscape metrics include the number of patches (NP), the landscape total area (TA), the aggregation index (AI), the largest patch index (LPI), the mean patch area (AREA_MN), the landscape shape index (LSI), the total edge length (TE), the edge density (ED), and the mean radius of gyration (GYRATE_MN). The experimental results reveal that, in 1994-2012, the total urban area of cities in Shandong province expanded for 1.17 times, the average urban area increased by about 93.00%, the average annual growth rate of the TE metric is 2.67 %, while the ED metric decreased about 1.44 % annually. Bigger cities in this area show relative slower urbanization development processes, such as Jinan and Qingdao. Coastal cities represented much more rapid expansion velocities than inland cities. In the middle area of Shandong province, the connectivity between developed urban areas was constantly increased.

Systematic Planning of Adaptation Options for Pluvial Flood Resilience

NASA Astrophysics Data System (ADS)

Babovic, Filip; Mijic, Ana; Madani, Kaveh

2016-04-01

Different elements of infrastructure and the built environment vary in their ability to quickly adapt to changing circumstances. Furthermore, many of the slowest, and often largest infrastructure adaptations, offer the greatest improvements to system performance. In the context of de-carbonation of individual buildings Brand (1995) identified six potential layers of adaptation based on their renewal times ranging from daily to multi-decadal time scales. Similar layers exist in urban areas with regards to Water Sensitive Urban Design (WSUD) and pluvial flood risk. These layers range from appliances within buildings to changes in the larger urban form. Changes in low-level elements can be quickly implemented, but are limited in effectiveness, while larger interventions occur at a much slower pace but offer greater benefits as a part of systemic change. In the context of urban adaptation this multi-layered approach provides information on how to order urban adaptations. This information helps to identify potential pathways by prioritising relatively quick adaptations to be implemented in the short term while identifying options which require more long term planning with respect to both uncertainty and flexibility. This information is particularly critical in the evolution towards more resilient and water sensitive cities (Brown, 2009). Several potential adaptation options were identified ranging from small to large-scale adaptations. The time needed for the adaptation to be implemented was estimated and curves representing the added drainage capacity per year were established. The total drainage capacity added by each option was then established. This methodology was utilised on a case study in the Cranbrook Catchment in the North East of London. This information was able to provide insight on how to best renew or extend the life of critical ageing infrastructure.

Dispersed three-pulse infrared photon echoes of nitrous oxide in water and octanol.

PubMed

Shattuck, J T; Schneck, J R; Chieffo, L R; Erramilli, S; Ziegler, L D

2013-12-12

Dispersed IR three-pulse photon echoes due to the antisymmetric (ν3) stretch mode of N2O dissolved in H2O and 1-octanol at room temperature are reported and analyzed. The experimentally determined transition frequency-frequency correlation function (FFCF) in these two solvents is explained in terms of inertial solvent contributions, hydrogen bond network fluctuations, and, for octanol, the motions of the alkyl chains. The H2O hydrogen bond fluctuations result in 1.5 ps FFCF decay, in agreement with relaxation rates determined from photon echo based measurements of other aqueous solutions including salt solutions. In octanol, hydrogen bond fluctuations decay on a slower time scale of 3.3 ps and alkyl chain motions result in an inhomogeneous broadening contribution to the ν3 absorption spectrum that decays on a 35 ps time scale. Rotational reorientation of N2O is nearly 3 times faster in octanol as compared to water. Although the vibrational ν3 N2O absorption line shapes in water and octanol are similar, the line widths result from different coherence loss mechanisms. A hot band contribution in the N2O in octanol solution is found to have a significant effect on the echo spectrum due to its correspondingly stronger transition moment than that of the fundamental transition. The dephasing dynamics of the N2O ν3 stretch mode is of interest as a probe in ultrafast studies of complex or nanoconfined systems with both hydrophobic and hydrophilic regions such as phospholipids, nucleic acids, and proteins. These results demonstrate the value of the N2O molecule to act as a reporter of equilibrium fluctuations in such complex systems particularly due to its solubility characteristics and long vibrational lifetime.

Radiolytic formation of the carbon dioxide radical anion in acetonitrile revealed by transient IR spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grills, David Charles; Lymar, Sergei

In this study, the solvated electron in CH 3CN is scavenged by CO 2 with a rate constant of 3.2 × 10 10 M –1 s –1 to produce the carbon dioxide radical anion (CO 2 •–), a strong and versatile reductant. Using pulse radiolysis with time-resolved IR detection, this radical is unambiguously identified by its absorption band at 1650 cm –1 corresponding to the antisymmetric CO 2 •– stretch. This assignment is confirmed by 13C isotopic labelling experiments and DFT calculations. In neat CH 3CN, CO 2 •– decays on a ~10 μs time scale via recombination with solvent-derivedmore » radicals (R•) and solvated protons. Upon addition of formate (HCO 2 –), the radiation yield of CO 2 •– is substantially increased due to H-atom abstraction by R• from HCO 2 – (R• + HCO 2 – → RH + CO 2 •–), which occurs in two kinetically separated steps. The rapid step involves the stronger H-abstracting CN•, CH 3•, and possibly, H• primary radicals, while the slower step is due to the less reactive, but more abundant radical, CH 2CN•. The removal of solvent radicals by HCO 2 – also results in over a hundredfold increase in the CO 2 •– lifetime. CO 2 •– scavenging experiments suggest that at 50 mM HCO 2 –, about 60% of the solvent-derived radicals are engaged in CO 2 •– generation. Finally, even under CO 2 saturation, no formation of the radical adduct, (CO 2) 2 •–, could be detected on the microsecond time scale.« less

Mesoscale Convective Vortices in Multiscale, Idealized Simulations: Dependence on Background State, Interdependency with Moist Baroclinic Cyclones, and Comparison with BAMEX Observations

DTIC Science & Technology

2010-04-01

to be 700 km. The scale of devel- opment is therefore within the fast -growing, smaller wavenumber portion of the large cyclone growth regime...the baroclinic conversion term CA increases about half as fast as it does in the corresponding moist experiment. In the moist case, CA reaches its...conversion of mean-state APE to eddy APE is slower, so the occlusion process is delayed and the system con- tinues deepening, although not as fast as in the

Violation of the 2nd Law of Thermodynamics in the Quantum Microworld

NASA Astrophysics Data System (ADS)

Čápek, V.; Frege, O.

2002-05-01

For one open quantum system recently reported to work as a perpetuum mobile of the second kind, basic equations providing basis for discussion of physics beyond the system activity are rederived in an appreciably simpler manner. The equations become exact in one specific scaling limit corresponding to the physical regime where internal processes (relaxations) in the system are commensurable or even slower than relaxation processes induced by bath. In the high-temperature (i.e. classical) limit, the system ceases to work, i.e., validity of the second law is reestablished.

When Human Walking is a Random Walk

NASA Astrophysics Data System (ADS)

Hausdorff, J. M.

1998-03-01

The complex, hierarchical locomotor system normally does a remarkable job of controlling an inherently unstable, multi-joint system. Nevertheless, the stride interval --- the duration of a gait cycle --- fluctuates from one stride to the next, even under stationary conditions. We used random walk analysis to study the dynamical properties of these fluctuations under normal conditions and how they change with disease and aging. Random walk analysis of the stride-to-stride fluctuations of healthy, young adult men surprisingly reveals a self-similar pattern: fluctuations at one time scale are statistically similar to those at multiple other time scales (Hausdorff et al, J Appl Phsyiol, 1995). To study the stability of this fractal property, we analyzed data obtained from healthy subjects who walked for 1 hour at their usual pace, as well as at slower and faster speeds. The stride interval fluctuations exhibited long-range correlations with power-law decay for up to a thousand strides at all three walking rates. In contrast, during metronomically-paced walking, these long-range correlations disappeared; variations in the stride interval were uncorrelated and non-fractal (Hausdorff et al, J Appl Phsyiol, 1996). To gain insight into the mechanism(s) responsible for this fractal property, we examined the effects of aging and neurological impairment. Using detrended fluctuation analysis (DFA), we computed α, a measure of the degree to which one stride interval is correlated with previous and subsequent intervals over different time scales. α was significantly lower in healthy elderly subjects compared to young adults (p < .003) and in subjects with Huntington's disease, a neuro-degenerative disorder of the central nervous system, compared to disease-free controls (p < 0.005) (Hausdorff et al, J Appl Phsyiol, 1997). α was also significantly related to degree of functional impairment in subjects with Huntington's disease (r=0.78). Recently, we have observed that just as there are changes with α during aging, there also changes with development. Apparently, the fractal scaling of walking does not become mature until children are eleven years old. Conclusions: The fractal dynamics of spontaneous stride interval fluctuations are normally quite robust and are apparently intrinsic to the healthy adult locomotor system. However, alterations in this fractal scaling property are associated with impairment in central nervous system control, aging and neural development.

Laboratory investigations of the effects of geologic heterogeneity on groundwater salinization and flush-out times from a tsunami-like event.

PubMed

Vithanage, M; Engesgaard, P; Jensen, K H; Illangasekare, T H; Obeysekera, J

2012-08-01

This intermediate scale laboratory experimental study was designed to improve the conceptual understanding of aquifer flushing time associated with diffuse saltwater contamination of coastal aquifers due to a tsunami-like event. The motivation comes from field observations made after the tsunami in December, 2004 in South Asia. The focus is on the role and effects of heterogeneity on flushing effectiveness. A scheme that combines experimentation in a 4.8m long laboratory tank and numerical modeling was used. To demonstrate the effects of geologic heterogeneity, plume migration and flushing times were analyzed in both homogeneous and layered media and under different boundary conditions (ambient flow, saltwater infiltration rate, freshwater recharge). Saltwater and freshwater infiltrations imitate the results of the groundwater salinization from the tsunami and freshening from the monsoon rainfall. The saltwater plume behavior was monitored both through visual observations (digital photography) of the dyed salt water and using measurements taken from several electrical conductivity sensors installed through the tank walls. The variable-density, three dimensional code HST3D was used to simulate the tank experiments and understand the fate and movement of the saltwater plume under field conditions. The results from the tank experiments and modeling demonstrated that macro-scale heterogeneity significantly influenced the migration patterns and flushing times of diffuse saltwater contamination. Ambient flow had a direct influence on total flush-out time, and heterogeneity impacted flush-out times for the top part of the tank and total flush-out times. The presence of a continuous low-permeability layer caused a 40% increase in complete flush-out time due to the slower flow of salt water in the low-permeability layer. When a relatively small opening was introduced in the low-permeability layer, salt water migrated quickly into a higher-permeable layer below causing a reduction in flush-out time. Freshwater recharge caused an early dilution of salt water in the top part of the tank in the case of a layered media, but also pushed the saltwater plume into the low-permeability layer which led to increased total flush-out times. Copyright © 2012 Elsevier B.V. All rights reserved.

[Interspecies differences of noopept pharmacokinetics].

PubMed

Boĭko, S S; Korotkov, S A; Zherdev, V P; Gudasheva, T A; Ostrovskaia, R U; Voronina, T A

2004-01-01

Significant interspecific differences in the pharmacokinetics of noopept are manifested by a decrease in the drug elimination rate on the passage from rats to rabbits and humans. Very intensive metabolism of noopept was observed upon intravenous administration in rats. In these animals, presystemic elimination mechanisms lead to the formation of a specific metabolite representing a product of drug biotransformation hydroxylated at the phenyl ring. In rabbits, unchanged noopept circulates in the blood for a longer time upon both intravenous and peroral introduction, biotransformation proceeds at a much slower rate, and no metabolites analogous to that found in rats are detected. The noopept pharmacokinetics in humans differs from that in animals by still slower elimination and considerable individual variability. No drug metabolites are found in the human blood plasma, probably because of a relatively small dose and low concentration.

Ultrafast energy relaxation in single light-harvesting complexes

DOE PAGES

Maly, Pavel; Gruber, J. Michael; Cogdell, Richard J.; ...

2016-02-22

Energy relaxation in light-harvesting complexes has been extensively studied by various ultrafast spectroscopic techniques, the fastest processes being in the sub–100-fs range. At the same time, much slower dynamics have been observed in individual complexes by single-molecule fluorescence spectroscopy (SMS). In this work, we use a pump–probe-type SMS technique to observe the ultrafast energy relaxation in single light-harvesting complexes LH2 of purple bacteria. After excitation at 800 nm, the measured relaxation time distribution of multiple complexes has a peak at 95 fs and is asymmetric, with a tail at slower relaxation times. When tuning the excitation wavelength, the distribution changesmore » in both its shape and position. The observed behavior agrees with what is to be expected from the LH2 excited states structure. As we show by a Redfield theory calculation of the relaxation times, the distribution shape corresponds to the expected effect of Gaussian disorder of the pigment transition energies. By repeatedly measuring few individual complexes for minutes, we find that complexes sample the relaxation time distribution on a timescale of seconds. Furthermore, by comparing the distribution from a single long-lived complex with the whole ensemble, we demonstrate that, regarding the relaxation times, the ensemble can be considered ergodic. Lastly, our findings thus agree with the commonly used notion of an ensemble of identical LH2 complexes experiencing slow random fluctuations.« less

Ultrafast energy relaxation in single light-harvesting complexes.

PubMed

Malý, Pavel; Gruber, J Michael; Cogdell, Richard J; Mančal, Tomáš; van Grondelle, Rienk

2016-03-15

Energy relaxation in light-harvesting complexes has been extensively studied by various ultrafast spectroscopic techniques, the fastest processes being in the sub-100-fs range. At the same time, much slower dynamics have been observed in individual complexes by single-molecule fluorescence spectroscopy (SMS). In this work, we use a pump-probe-type SMS technique to observe the ultrafast energy relaxation in single light-harvesting complexes LH2 of purple bacteria. After excitation at 800 nm, the measured relaxation time distribution of multiple complexes has a peak at 95 fs and is asymmetric, with a tail at slower relaxation times. When tuning the excitation wavelength, the distribution changes in both its shape and position. The observed behavior agrees with what is to be expected from the LH2 excited states structure. As we show by a Redfield theory calculation of the relaxation times, the distribution shape corresponds to the expected effect of Gaussian disorder of the pigment transition energies. By repeatedly measuring few individual complexes for minutes, we find that complexes sample the relaxation time distribution on a timescale of seconds. Furthermore, by comparing the distribution from a single long-lived complex with the whole ensemble, we demonstrate that, regarding the relaxation times, the ensemble can be considered ergodic. Our findings thus agree with the commonly used notion of an ensemble of identical LH2 complexes experiencing slow random fluctuations.

Ultrafast energy relaxation in single light-harvesting complexes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maly, Pavel; Gruber, J. Michael; Cogdell, Richard J.

Energy relaxation in light-harvesting complexes has been extensively studied by various ultrafast spectroscopic techniques, the fastest processes being in the sub–100-fs range. At the same time, much slower dynamics have been observed in individual complexes by single-molecule fluorescence spectroscopy (SMS). In this work, we use a pump–probe-type SMS technique to observe the ultrafast energy relaxation in single light-harvesting complexes LH2 of purple bacteria. After excitation at 800 nm, the measured relaxation time distribution of multiple complexes has a peak at 95 fs and is asymmetric, with a tail at slower relaxation times. When tuning the excitation wavelength, the distribution changesmore » in both its shape and position. The observed behavior agrees with what is to be expected from the LH2 excited states structure. As we show by a Redfield theory calculation of the relaxation times, the distribution shape corresponds to the expected effect of Gaussian disorder of the pigment transition energies. By repeatedly measuring few individual complexes for minutes, we find that complexes sample the relaxation time distribution on a timescale of seconds. Furthermore, by comparing the distribution from a single long-lived complex with the whole ensemble, we demonstrate that, regarding the relaxation times, the ensemble can be considered ergodic. Lastly, our findings thus agree with the commonly used notion of an ensemble of identical LH2 complexes experiencing slow random fluctuations.« less

Acoustics of multiscale sorptive porous materials

NASA Astrophysics Data System (ADS)

Venegas, R.; Boutin, C.; Umnova, O.

2017-08-01

This paper investigates sound propagation in multiscale rigid-frame porous materials that support mass transfer processes, such as sorption and different types of diffusion, in addition to the usual visco-thermo-inertial interactions. The two-scale asymptotic method of homogenization for periodic media is successively used to derive the macroscopic equations describing sound propagation through the material. This allowed us to conclude that the macroscopic mass balance is significantly modified by sorption, inter-scale (micro- to/from nanopore scales) mass diffusion, and inter-scale (pore to/from micro- and nanopore scales) pressure diffusion. This modification is accounted for by the dynamic compressibility of the effective saturating fluid that presents atypical properties that lead to slower speed of sound and higher sound attenuation, particularly at low frequencies. In contrast, it is shown that the physical processes occurring at the micro-nano-scale do not affect the macroscopic fluid flow through the material. The developed theory is exemplified by introducing an analytical model for multiscale sorptive granular materials, which is experimentally validated by comparing its predictions with acoustic measurements on granular activated carbons. Furthermore, we provide empirical evidence supporting an alternative method for measuring sorption and mass diffusion properties of multiscale sorptive materials using sound waves.

Cumulative Significance of Hyporheic Exchange and Biogeochemical Processing in River Networks

NASA Astrophysics Data System (ADS)

Harvey, J. W.; Gomez-Velez, J. D.

2014-12-01

Biogeochemical reactions in rivers that decrease excessive loads of nutrients, metals, organic compounds, etc. are enhanced by hydrologic interactions with microbially and geochemically active sediments of the hyporheic zone. The significance of reactions in individual hyporheic flow paths has been shown to be controlled by the contact time between river water and sediment and the intrinsic reaction rate in the sediment. However, little is known about how the cumulative effects of hyporheic processing in large river basins. We used the river network model NEXSS (Gomez-Velez and Harvey, submitted) to simulate hyporheic exchange through synthetic river networks based on the best available models of network topology, hydraulic geometry and scaling of geomorphic features, grain size, hydraulic conductivity, and intrinsic reaction rates of nutrients and metals in river sediment. The dimensionless reaction significance factor, RSF (Harvey et al., 2013) was used to quantify the cumulative removal fraction of a reactive solute by hyporheic processing. SF scales reaction progress in a single pass through the hyporheic zone with the proportion of stream discharge passing through the hyporheic zone for a specified distance. Reaction progress is optimal where the intrinsic reaction timescale in sediment matches the residence time of hyporheic flow and is less efficient in longer residence time hyporheic flow as a result of the decreasing proportion of river flow that is processed by longer residence time hyporheic flow paths. In contrast, higher fluxes through short residence time hyporheic flow paths may be inefficient because of the repeated surface-subsurface exchanges required to complete the reaction. Using NEXSS we found that reaction efficiency may be high in both small streams and large rivers, although for different reasons. In small streams reaction progress generally is dominated by faster pathways of vertical exchange beneath submerged bedforms. Slower exchange beneath meandering river banks mainly has importance only in large rivers. For solutes entering networks in proportion to water inputs it is the lower order streams that tend to dominate cumulative reaction progress.

Mid-life socioeconomic status, depressive symptomatology and general cognitive status among older adults: inter-relationships and temporal effects.

PubMed

Chiao, Chi; Weng, Li-Jen

2016-04-20

Few longitudinal studies have analyzed how socioeconomic status (SES) influences both depressive and cognitive development over an individual's life course. This study investigates the change trajectories of both depressive symptomatology and general cognitive status, as well as their associations over time, focusing on the effects of mid-life SES. Data were obtained from the Taiwan Longitudinal Study on Aging (1993-2007), a nationally representative cohort study of older adults in Taiwan. The short form of the Center of Epidemiological Studies-Depression (CES-D) scale that measures depressive symptomatology in two domains (negative affect and lack of positive affect) was used. General cognitive status was assessed using the brief Short Portable Mental Status Questionnaire scale. Assessments of the subjects' mid-life SES included measurement of the participant's education and occupation. Analyses were conducted by the parallel latent growth curve modeling. The participants' initial levels of depressive symptomatology and general cognitive status were significantly and negatively correlated; furthermore, any changes in these two outcomes were also correlated over time. The initial assessment of general cognitive status significantly contributed to any advancement towards more severe depressive symptomatology over time, particularly when this occurred in a negative manner. Furthermore, a mid-life SES advantage resulted in a significant reduction in late-life depressive symptomatology and also produced a slower decline in general cognitive status during later life. In contrast, lower mid-life SES exacerbated depressive symptomatology during old age, both at the initial assessment and in terms of the change over time. In addition, female gender was significantly associated with lower general cognitive status and more severe depressive symptomatology in negative affect. These findings suggest a complex and longitudinal association between depressive symptomatology and general cognitive status in later life and this complicated relationship seems to be affected by mid-life SES over time.

49 CFR 7.32 - Final determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... component using multitrack processing may provide persons making appeals in its slower track(s) with an... Transportation Office of the Secretary of Transportation PUBLIC AVAILABILITY OF INFORMATION Time Limits § 7.32... extended by up to ten Federal working days in accordance with § 7.33. The person making the request will be...

Visual Processing Deficits in Children with Slow RAN Performance

ERIC Educational Resources Information Center

Stainthorp, Rhona; Stuart, Morag; Powell, Daisy; Quinlan, Philip; Garwood, Holly

2010-01-01

Two groups of 8- to 10-year-olds differing in rapid automatized naming speed but matched for age, verbal and nonverbal ability, phonological awareness, phonological memory, and visual acuity participated in four experiments investigating early visual processing. As low RAN children had significantly slower simple reaction times (SRT) this was…

Automatic Activation of Exercise and Sedentary Stereotypes

ERIC Educational Resources Information Center

Berry, Tanya; Spence, John C.

2009-01-01

We examined the automatic activation of "sedentary" and "exerciser" stereotypes using a social prime Stroop task. Results showed significantly slower response times between the exercise words and the exercise control words and between the sedentary words and the exercise control words when preceded by an attractive exerciser prime. Words preceded…

How can radio frequency identification technology impact nursing practice?

PubMed

Billingsley, Luanne; Wyld, David

2014-12-01

Radio frequency identification (RFID) technology can save nurses time, improve quality of care, en hance patient and staff safety, and decrease costs. However, without a better understanding of these systems and their benefits to patients and hospitals, nurses may be slower to recommend, implement, or adopt RFID technology into practice.

77 FR 30238 - Living History Flight Experience (LHFE)-Exemptions for Passenger Carrying Operations Conducted...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... significant, American- manufactured large, crew-served, piston-powered, multi-engine, World War II bomber... public safety (e.g., older and slower multi-engine which airplanes allow time for appropriate corrective... air show that was piloted by two highly qualified and well-trained flight crewmembers clearly...

Effect of exercise intensity on post-exercise oxygen consumption and heart rate recovery.

PubMed

Mann, Theresa N; Webster, Christopher; Lamberts, Robert P; Lambert, Michael I

2014-09-01

There is some evidence that measures of acute post-exercise recovery are sensitive to the homeostatic stress of the preceding exercise and these measurements warrant further investigation as possible markers of training load. The current study investigated which of four different measures of metabolic and autonomic recovery was most sensitive to changes in exercise intensity. Thirty-eight moderately trained runners completed 20-min bouts of treadmill exercise at 60, 70 and 80% of maximal oxygen uptake (VO2max) and four different recovery measurements were determined: the magnitude of excess post-exercise oxygen consumption (EPOCMAG), the time constant of the oxygen consumption recovery curve (EPOCτ), heart rate recovery within 1 min (HRR60s) and the time constant of the heart rate recovery curve (HRRτ) . Despite significant differences in exercise parameters at each exercise intensity, only EPOCMAG showed significantly slower recovery with each increase in exercise intensity at the group level and in the majority of individuals. EPOCτ was significantly slower at 70 and 80% of VO₂max vs. 60% VO₂max and HRRτ was only significantly slower when comparing the 80 vs. 60% VO₂max exercise bouts. In contrast, HRR60s reflected faster recovery at 70 and 80% of VO₂max than at 60% VO₂max. Of the four recovery measurements investigated, EPOCMAG was the most sensitive to changes in exercise intensity and shows potential to reflect changes in the homeostatic stress of exercise at the group and individual level. Determining EPOCMAG may help to interpret the homeostatic stress of laboratory-based research trials or training sessions.

Effects of spin transition on diffusion of Fe2+ in ferropericlase in Earth's lower mantle

NASA Astrophysics Data System (ADS)

Saha, Saumitra; Bengtson, Amelia; Crispin, Katherine L.; van Orman, James A.; Morgan, Dane

2011-11-01

Knowledge of Fe composition in lower-mantle minerals (primarily perovskite and ferropericlase) is essential to a complete understanding of the Earth's interior. Fe cation diffusion potentially controls many aspects of the distribution of Fe in the Earth's lower mantle, including mixing of chemical heterogeneities, element partitioning, and the extent of core-mantle communications. Fe in ferropericlase has been shown to undergo a spin transition starting at about 40 GPa and exists in a mixture of high-spin and low-spin states over a wide range of pressures. Present experimental data on Fe transport in ferropericlase is limited to pressures below 35 GPa and provides little information on the pressure dependence of the activation volume and none on the impact of the spin transition on diffusion. Therefore, known experimental data on Fe diffusion cannot be reliably extrapolated to predict diffusion throughout the lower mantle. Here, first-principles and statistical modeling are combined to predict diffusion of Fe in ferropericlase over the entire lower mantle, including the effects of the Fe spin transition. A thorough statistical thermodynamic treatment is given to fully incorporate the coexistence of high- and low-spin Fe in the model of overall Fe diffusion in the lower mantle. Pure low-spin Fe diffuses approximately 104 times slower than high-spin Fe in ferropericlase but Fe diffusion of the mixed-spin state is only about 10 times slower than that of high-spin Fe. The predicted Fe diffusivities demonstrate that ferropericlase is unlikely to be rate limiting in transporting Fe in deep earth since much slower Fe diffusion in perovskite is predicted.

Altered spatiotemporal characteristics of gait in older adults with chronic low back pain.

PubMed

Hicks, Gregory E; Sions, J Megan; Coyle, Peter C; Pohlig, Ryan T

2017-06-01

Previous studies in older adults have identified that chronic low back pain (CLBP) is associated with slower gait speed. Given that slower gait speed is a predictor of greater morbidity and mortality among older adults, it is important to understand the underlying spatiotemporal characteristics of gait among older adults with CLBP. The purposes of this study were to determine (1) if there are differences in spatiotemporal parameters of gait between older adults with and without CLBP during self-selected and fast walking and (2) whether any of these gait characteristics are correlated with performance of a challenging walking task, e.g. stair negotiation. Spatiotemporal characteristics of gait were evaluated using a computerized walkway in 54 community-dwelling older adults with CLBP and 54 age- and sex-matched healthy controls. Older adults with CLBP walked slower than their pain-free peers during self-selected and fast walking. After controlling for body mass index and gait speed, step width was significantly greater in the CLBP group during the fast walking condition. Within the CLBP group, step width and double limb support time are significantly correlated with stair ascent/descent times. From a clinical perspective, these gait characteristics, which may be indicative of balance performance, may need to be addressed to improve overall gait speed, as well as stair-climbing performance. Future longitudinal studies confirming our findings are needed, as well as investigations focused on developing interventions to improve gait speed and decrease subsequent risk of mobility decline. Copyright © 2017 Elsevier B.V. All rights reserved.

Rate of nicotine metabolism and smoking cessation outcomes in a community-based sample of treatment-seeking smokers.

PubMed

Kaufmann, Amanda; Hitsman, Brian; Goelz, Patricia M; Veluz-Wilkins, Anna; Blazekovic, Sonja; Powers, Lindsay; Leone, Frank T; Gariti, Peter; Tyndale, Rachel F; Schnoll, Robert A

2015-12-01

In samples from controlled randomized clinical trials, a smoker's rate of nicotine metabolism, measured by the 3-hydroxycotinine to cotinine ratio (NMR), predicts response to transdermal nicotine. Replication of this relationship in community-based samples of treatment-seeking smokers may help guide the implementation of the NMR for personalized treatment for nicotine dependence. Data from a community-based sample of treatment seeking smokers (N=499) who received 8weeks of transdermal nicotine and 4 behavioral counseling sessions were used to evaluate associations between the NMR and smoking cessation. Secondary outcomes included withdrawal and craving, depression and anxiety, side effects, and treatment adherence. The NMR was a significant predictor of abstinence (OR=.56, 95% CI: 0.33-0.95, p=.03), with faster metabolizers showing lower quit rates than slower metabolizers (24% vs. 33%). Faster nicotine metabolizers exhibited significantly higher levels of anxiety symptoms over time during treatment, vs. slower metabolizers (NMR x Time interaction: F[3,357]=3.29, p=.02). NMR was not associated with changes in withdrawal, craving, depression, side effects, and treatment adherence (p's>.05). In a community-based sample of treatment-seeking smokers, faster nicotine metabolizers were significantly less likely to quit smoking and showed higher rates of anxiety symptoms during a smoking cessation treatment program, vs. slower nicotine metabolizers. These results provide further evidence that transdermal nicotine is less effective for faster nicotine metabolizers and suggest the need to address cessation-induced anxiety symptoms among these smokers to increase the chances for successful smoking cessation. Copyright © 2015 Elsevier Ltd. All rights reserved.

Independent influence of gait speed and step length on stability and fall risk.

PubMed

Espy, D D; Yang, F; Bhatt, T; Pai, Y-C

2010-07-01

With aging, individuals' gaits become slower and their steps shorter; both are thought to improve stability against balance threats. Recent studies have shown that shorter step lengths, which bring the center of mass (COM) closer to the leading foot, improve stability against slip-related falls. However, a slower gait, hence lower COM velocity, does the opposite. Due to the inherent coupling of step length and speed in spontaneous gait, the extent to which the benefit of shorter steps can offset the slower speed is unknown. The purpose of this study was to investigate, through decoupling, the independent effects of gait speed and step length on gait stability and the likelihood of slip-induced falls. Fifty-seven young adults walked at one of three target gait patterns, two of equal speed and two of equal step length; at a later trial, they encountered an unannounced slip. The results supported our hypotheses that faster gait as well as shorter steps each ameliorates fall risk when a slip is encountered. This appeared to be attributable to the maintenance of stability from slip initiation to liftoff of the recovery foot during the slip. Successful decoupling of gait speed from step length reveals for the first time that, although slow gait in itself leads to instability and falls (a one-standard-deviation decrease in gait speed increases the odds of fall by 4-fold), this effect is offset by the related decrease in step length (the same one-standard-deviation decrease in step length lowers fall risk by 6 times). Copyright © 2010 Elsevier B.V. All rights reserved.

The Winding Paths of the Lonesome Cowboy: Evidence for Mutual Influences Between Personality, Subjective Health, and Loneliness.

PubMed

Mund, Marcus; Neyer, Franz J

2016-10-01

Prior research demonstrated influences of personality traits and their development on later status of subjective health and loneliness. In the present study, we intended to extend these findings by examining mutual influences between health-related characteristics and personality traits and their development over time. German adults were assessed at two time points across 15 years (NT1  = 654, NT2  = 271; Mage at Time 1 = 24.39, SD = 3.69). Data were analyzed with multivariate structural equation models and a multivariate latent change model. Neuroticism was found to predict later levels and the development of subjective health and loneliness. While subjective health likewise predicted later levels of Neuroticism, loneliness was found to be predictive of later levels as well as the development of Neuroticism, Extraversion, and Conscientiousness. Correlated changes indicated that developing a socially more desirable personality is associated with slower declines in subjective health and slower increases in loneliness. The findings indicate that characteristics related to an individual's health are reciprocally associated with personality traits. Thus, the study adds to the understanding of the development of personality and health-related characteristics. © 2015 Wiley Periodicals, Inc.

Revisit the faster-is-slower effect for an exit at a corner

NASA Astrophysics Data System (ADS)

Chen, Jun Min; Lin, Peng; Wu, Fan Yu; Li Gao, Dong; Wang, Guo Yuan

2018-02-01

The faster-is-slower effect (FIS), which means that crowd at a high enough velocity could significantly increase the evacuation time to escape through an exit, is an interesting phenomenon in pedestrian dynamics. Such phenomenon had been studied widely and has been experimentally verified in different systems of discrete particles flowing through a centre exit. To experimentally validate this phenomenon by using people under high pressure is difficult due to ethical issues. A mouse, similar to a human, is a kind of self-driven and soft body creature with competitive behaviour under stressed conditions. Therefore, mice are used to escape through an exit at a corner. A number of repeated tests are conducted and the average escape time per mouse at different levels of stimulus are analysed. The escape times do not increase obviously with the level of stimulus for the corner exit, which is contrary to the experiment with the center exit. The experimental results show that the FIS effect is not necessary a universal law for any discrete system. The observation could help the design of buildings by relocating their exits to the corner in rooms to avoid the formation of FIS effect.

An investigation of spatial representation of pitch in individuals with congenital amusia.

PubMed

Lu, Xuejing; Sun, Yanan; Thompson, William Forde

2017-09-01

Spatial representation of pitch plays a central role in auditory processing. However, it is unknown whether impaired auditory processing is associated with impaired pitch-space mapping. Experiment 1 examined spatial representation of pitch in individuals with congenital amusia using a stimulus-response compatibility (SRC) task. For amusic and non-amusic participants, pitch classification was faster and more accurate when correct responses involved a physical action that was spatially congruent with the pitch height of the stimulus than when it was incongruent. However, this spatial representation of pitch was not as stable in amusic individuals, revealed by slower response times when compared with control individuals. One explanation is that the SRC effect in amusics reflects a linguistic association, requiring additional time to link pitch height and spatial location. To test this possibility, Experiment 2 employed a colour-classification task. Participants judged colour while ignoring a concurrent pitch by pressing one of two response keys positioned vertically to be congruent or incongruent with the pitch. The association between pitch and space was found in both groups, with comparable response times in the two groups, suggesting that amusic individuals are only slower to respond to tasks involving explicit judgments of pitch.

In vivo growth of 60 non-screening detected lung cancers: a computed tomography study.

PubMed

Mets, Onno M; Chung, Kaman; Zanen, Pieter; Scholten, Ernst T; Veldhuis, Wouter B; van Ginneken, Bram; Prokop, Mathias; Schaefer-Prokop, Cornelia M; de Jong, Pim A

2018-04-01

Current pulmonary nodule management guidelines are based on nodule volume doubling time, which assumes exponential growth behaviour. However, this is a theory that has never been validated in vivo in the routine-care target population. This study evaluates growth patterns of untreated solid and subsolid lung cancers of various histologies in a non-screening setting.Growth behaviour of pathology-proven lung cancers from two academic centres that were imaged at least three times before diagnosis (n=60) was analysed using dedicated software. Random-intercept random-slope mixed-models analysis was applied to test which growth pattern most accurately described lung cancer growth. Individual growth curves were plotted per pathology subgroup and nodule type.We confirmed that growth in both subsolid and solid lung cancers is best explained by an exponential model. However, subsolid lesions generally progress slower than solid ones. Baseline lesion volume was not related to growth, indicating that smaller lesions do not grow slower compared to larger ones.By showing that lung cancer conforms to exponential growth we provide the first experimental basis in the routine-care setting for the assumption made in volume doubling time analysis. Copyright ©ERS 2018.

Detection of a magnetic field on HD108: clues to extreme magnetic braking and the Of?p phenomenon

NASA Astrophysics Data System (ADS)

Martins, F.; Donati, J.-F.; Marcolino, W. L. F.; Bouret, J.-C.; Wade, G. A.; Escolano, C.; Howarth, I. D.; Mimes Collaboration

2010-09-01

We report the detection of a magnetic field on the Of?p star HD108. Spectropolarimetric observations conducted in 2007, 2008 and 2009, respectively, with NARVAL@Télescope Bernard Lyot (TBL) and Echelle SpectroPolarimetric Device for the Observation of Stars at Canada-France-Hawaii Telescope (ESPaDOnS@CFHT) reveal a clear Zeeman signature in the average Stokes V profile, stable on time-scales of days to months and slowly increasing in amplitude on time-scales of years. We speculate that this time-scale is the same as that on which Hα emission is varying and is equal to the rotation period of the star. The corresponding longitudinal magnetic field, measured during each of the three seasons, increases slowly from 100 to 150 G, implying that the polar strength of the putatively dipolar large-scale magnetic field of HD108 is at least 0.5 kG and most likely of the order of 1-2 kG. The stellar and wind properties are derived through a quantitative spectroscopic analysis with the code CMFGEN. The effective temperature is difficult to constrain because of the unusually strong HeI λλ4471, 5876 lines. Values in the range of 33000-37000K are preferred. A mass-loss rate of about 10-7Msolaryr-1 (with a clumping factor f = 0.01) and a wind terminal velocity of 2000 km s-1 are derived. The wind confinement parameter η* is larger than 100, implying that the wind of HD108 is magnetically confined. Stochastic short-term variability is observed in the wind-sensitive lines but not in the photospheric lines, excluding the presence of pulsations. Material infall in the confined wind is the most likely origin for lines formed in the inner wind. Wind clumping also probably causes part of the Hα variability. The projected rotational velocity of HD108 is lower than 50 km s-1, consistent with the spectroscopic and photometric variation time-scales of a few decades. Overall, HD108 is very similar to the magnetic O star HD191612 except for an even slower rotation. Based on observations obtained at the Télescope Bernard Lyot (TBL) and at the Canada-France-Hawaii Telescope (CFHT). CFHT is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France (INSU/CNRS), and the University of Hawaii, while TBL is operated by CNRS/INSU. E-mail: martins@graal.univ-montp2.fr

Influence of Voltage Rise Time for Oxidation Treatment of NO in Simulated Exhausted Gas by Polarity-Reversed Pulse Discharge

NASA Astrophysics Data System (ADS)

Shinmoto, Kazuya; Kadowaki, Kazunori; Nishimoto, Sakae; Kitani, Isamu

This paper describes experimental study on NO removal from a simulated exhausted-gas using repetitive surface discharge on a glass barrier subjected to polarity-reversed voltage pulses. The very fast polarity-reversal with a rise time of 20ns is caused by direct grounding of a charged coaxial cable of 10m in length. Influence of voltage rise time on energy efficiency for NO removal is studied. Results of NO removal using a barrier-type plasma reactor with screw-plane electrode system indicates that the energy efficiency for the very fast polarity reversal caused by direct grounding becomes higher than that for the slower polarity reversal caused by grounding through an inductor at the cable end. The energy efficiency for the direct grounding is about 80g/kWh for 50% NO removal ratio and is about 60g/kWh for 100% NO removal ratio. Very intense discharge light is observed at the initial time of 10ns for the fast polarity reversal, whereas the intensity in the initial discharge light for the slower polarity reversal is relatively small. To confirm the effectiveness of the polarity-reversed pulse application, comparison of the energy efficiency between the polarity-reversed voltage pulse and ac 60Hz voltage will be presented.

FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk

PubMed Central

Nikolova, Yuliya S.; Iruku, Swetha P.; Lin, Chien-Wei; Conley, Emily Drabant; Puralewski, Rachel; French, Beverly; Hariri, Ahmad R.; Sibille, Etienne

2015-01-01

The A allele of the FRAS1-related extracellular matrix protein 3 (FREM3) rs7676614 single nucleotide polymorphism (SNP) was linked to major depressive disorder (MDD) in an early genome-wide association study (GWAS), and to symptoms of psychomotor retardation in a follow-up investigation. In line with significant overlap between age- and depression-related molecular pathways, parallel work has shown that FREM3 expression in postmortem human brain decreases with age. Here, we probe the effect of rs7676614 on amygdala reactivity and perceptual processing speed, both of which are altered in depression and aging. Amygdala reactivity was assessed using a face-matching BOLD fMRI paradigm in 365 Caucasian participants in the Duke Neurogenetics Study (DNS) (192 women, mean age 19.7 ± 1.2). Perceptual processing speed was indexed by reaction times in the same task and the Trail Making Test (TMT). The effect of rs7676614 on FREM3 mRNA brain expression levels was probed in a postmortem cohort of 169 Caucasian individuals (44 women, mean age 50.8 ± 14.9). The A allele of rs7676614 was associated with blunted amygdala reactivity to faces, slower reaction times in the face-matching condition (p < 0.04), as well as marginally slower performance on TMT Part B (p = 0.056). In the postmortem cohort, the T allele of rs6537170 (proxy for the rs7676614 A allele), was associated with trend-level reductions in gene expression in Brodmann areas 11 and 47 (p = 0.066), reminiscent of patterns characteristic of older age. The low-expressing allele of another FREM3 SNP (rs1391187) was similarly associated with reduced amygdala reactivity and slower TMT Part B speed, in addition to reduced BA47 activity and extraversion (p < 0.05). Together, these results suggest common genetic variation associated with reduced FREM3 expression may confer risk for a subtype of depression characterized by reduced reactivity to environmental stimuli and slower perceptual processing speed, possibly suggestive of accelerated aging. PMID:26441752

Biological plywood film formation from para-nematic liquid crystalline organization.

PubMed

Aguilar Gutierrez, Oscar F; Rey, Alejandro D

2017-11-15

In vitro non-equilibrium chiral phase ordering processes of biomacromolecular solutions offer a systematic and reproducible way of generating material architectures found in Nature, such as biological plywoods. Accelerated progress in biomimetic engineering of mesoscopic plywoods and other fibrous structures requires a fundamental understanding of processing and transport principles. In this work we focus on collagen I based materials and structures to find processing conditions that lead to defect-free collagen films displaying the helicoidal plywood architecture. Here we report experimentally-guided theory and simulations of the chiral phase ordering of collagen molecules through water solvent evaporation of pre-aligned dilute collagen solutions. We develop, implement and a posteriori validate an integrated liquid crystal chiral phase ordering-water transport model that captures the essential features of spatio-temporal chiral structure formation in shrinking film domains due to directed water loss. Three microstructural (texture) modes are identified depending on the particular value of the time-scale ratio defined by collagen rotational diffusion to water translational diffusion. The magnitude of the time scale ratio provides the conditions for the synchronization of the helical axis morphogenesis with the increase in the mesogen concentration due to water loss. Slower than critical water removal rates leads to internal multiaxial cellular patterns, reminiscent of the classical columnar-equiaxed metallurgical casting structures. Excessive water removal rates lead to destabilization of the chiral axis and multidomain defected films. The predictions of the integrated model are in qualitative agreement with experimental results and can potentially guide solution processing of other bio-related mesogenic solutions that seek to mimic the architecture of biological fibrous composites.

Longitudinal associations between depression and problematic substance use in the Youth Partners in Care study.

PubMed

McKowen, James W; Tompson, Martha C; Brown, Timothy A; Asarnow, Joan R

2013-01-01

Large-scale treatment studies suggest that effective depression treatment and reduced depression are associated with improved substance use outcomes. Yet information is limited regarding the longitudinal association between depressive symptoms and problematic substance use and its predictors, particularly in real-world practice settings. Using latent growth modeling, we examined the (a) longitudinal association between depressive symptoms and problematic substance use, (b) impact of depressive symptoms on problematic substance use, (c) impact of problematic substance use on depressive symptoms, and (d) role of co-occurring symptoms on depression and problematic substance use. Participants were part of the Youth Partners in Care study, an effectiveness trial evaluating a quality improvement intervention for youth depression through primary care. This ethnically diverse sample included youths aged 13 to 21 years screening positive for depression from 5 health care organizations. Participants were followed 4 times over an 18-month period and assessed for both depressive symptoms and problematic substance use. Both depressive symptoms and problematic substance use declined over time. Higher baseline depressive symptoms predicted a slower decline in problematic substance use, but baseline problematic substance use did not predict changes in depressive symptoms. These prospective associations remained robust controlling for co-occurring symptoms. Results support prior large-scale depression studies indicating depression burden negatively impacts substance use outcome and extends these findings to real-world practice settings. Findings underscore the importance of addressing depression severity in youth with concurrent substance use problems, even in the context of comorbid symptoms of anxiety, delinquency, and aggression.

Effects of Cloud-Microphysics on Tropical Atmospheric Hydrologic Processes in the GEOS GCM

NASA Technical Reports Server (NTRS)

Lau, K. M.; Wu, H. T.; Sud, Y. C.; Walker, G. K.

2004-01-01

The sensitivity of tropical atmospheric hydrologic processes to cloud-microphysics is investigated using the NASA GEOS GCM. Results show that a faster autoconversion - rate produces more warm rain and less clouds at all levels. Fewer clouds enhances longwave cooling and reduces shortwave heating in the upper troposphere, while more warm rain produces increased condensation heating in the lower troposphere. This vertical heating differential destablizes the tropical atmosphere, producing a positive feedback resulting in more rain over the tropics. The feedback is maintained via a two-cell secondary circulation. The lower cell is capped by horizontal divergence and maximum cloud detrainment near the melting/freezing, with rising motion in the warm rain region connected to descending motion in the cold rain region. The upper cell is found above the freezing/melting level, with longwave-induced subsidence in the warm rain and dry regions, coupled to forced ascent in the deep convection region. The tropical large scale circulation is found to be very sensitive to the radiative-dynamic effects induced by changes in autoconversion rate. Reduced cloud-radiation processes feedback due to a faster autoconversion rate results in intermittent but more energetic eastward propagating Madden and Julian Oscillations (MJO). Conversely,-a slower autconversion rate, with increased cloud radiation produces MJO's with more realistic westward propagating transients, resembling a supercloud cluster structure. Results suggests that warm rain and associated low and mid level clouds, i.e., cumulus congestus, may play a critical role in regulating the time-intervals of deep convections and hence the fundamental time scales of the MJO.

Plasma Interaction with International Space Station High Voltage Solar Arrays

NASA Technical Reports Server (NTRS)

Heard, John W.

2002-01-01

The International Space Station (ISS) is presently being assembled in low-earth orbit (LEO) operating high voltage solar arrays (-160 V max, -140 V typical with respect to the ambient atmosphere). At the station's present altitude, there exists substantial ambient plasma that can interact with the solar arrays. The biasing of an object to an electric potential immersed in plasma creates a plasma "sheath" or non-equilibrium plasma around the object to mask out the electric fields. A positively biased object can collect electrons from the plasma sheath and the sheath will draw a current from the surrounding plasma. This parasitic current can enter the solar cells and effectively "short out" the potential across the cells, reducing the power that can be generated by the panels. Predictions of collected current based on previous high voltage experiments (SAMPIE (Solar Array Module Plasma Interactions Experiment), PASP+ (Photovoltaic Array Space Power) were on the order of amperes of current. However, present measurements of parasitic current are on the order of several milliamperes, and the current collection mainly occurs during an "eclipse exit" event, i.e., when the space station comes out of darkness. This collection also has a time scale, t approx. 1000 s, that is much slower than any known plasma interaction time scales. The reason for the discrepancy between predictions and present electron collection is not understood and is under investigation by the PCU (Plasma Contactor Unit) "Tiger" team. This paper will examine the potential structure within and around the solar arrays, and the possible causes and reasons for the electron collection of the array.

Differential Changes with Age in Multiscale Entropy of Electromyography Signals from Leg Muscles during Treadmill Walking

PubMed Central

Kang, Hyun Gu; Dingwell, Jonathan B.

2016-01-01

Age-related gait changes may be due to the loss of complexity in the neuromuscular system. This theory is disputed due to inconsistent results from single-scale analyses. Also, behavioral adaptations may confound these changes. We examined whether EMG dynamics during gait is less complex in older adults over a range of timescales using the multiscale entropy method, and whether slower walking attenuates this effect. Surface EMG was measured from the left vastus lateralis (VL), biceps femoris (BF), gastrocnemius (GA), and tibialis anterior (TA) in 17 young and 18 older adults as they walked on a treadmill for 5 minutes at 0.8x-1.2x of preferred speed. Sample entropy (SE) and the complexity index (CI) of the EMG signals were calculated after successive coarse-graining to extract dynamics at timescales of 27 to 270 Hz, with m = 2 and r = 0.15 SD. SE and CI were lower across the timescales in older adults in VL and BF, but higher in GA (all p<0.001); these results held for VL and GA even after accounting for longer EMG burst durations in older adults. CI was higher during slower walking speed in VL and BF (p<0.001). Results were mostly similar for m = 3 and r = 0.01–0.35. Smaller r was more sensitive to age-related differences. The decrease in complexity with aging in the timescales studied was limited to proximal muscles, particularly VL. The increase in GA may be driven by other factors. Walking slower may reflect a behavioral adaptation that allows the nervous system to function with greater complexity. PMID:27570974

Time-delayed reaction-diffusion fronts

NASA Astrophysics Data System (ADS)

Isern, Neus; Fort, Joaquim

2009-11-01

A time-delayed second-order approximation for the front speed in reaction-dispersion systems was obtained by Fort and Méndez [Phys. Rev. Lett. 82, 867 (1999)]. Here we show that taking proper care of the effect of the time delay on the reactive process yields a different evolution equation and, therefore, an alternate equation for the front speed. We apply the new equation to the Neolithic transition. For this application the new equation yields speeds about 10% slower than the previous one.

Late-time evolution of a self-interacting scalar field in the spacetime of a dilaton black hole

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moderski, Rafal; Rogatko, Marek

2001-08-15

We investigate the late-time tails of self-interacting (massive) scalar fields in the spacetime of a dilaton black hole. Following the no hair theorem we examine the mechanism by which self-interacting scalar hair decays. We reveal that the intermediate asymptotic behavior of the considered field perturbations is dominated by an oscillatory inverse power-law decaying tail. The numerical simulations show that at very late time, massive self-interacting scalar hair decays slower than any power law.

The Effects of Accelerator Frequency and Electron Beam Focusing in Free Electron Lasers

DTIC Science & Technology

2012-12-01

relative to one another. This freezing effect is a result of relativistic time dilation; in the lab frame, the relativistic electron bunch has a slower...average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed...is five months old at the time of this writing, and his smiles and hugs were a much needed treat when I returned home after long days of classes

Association of slower walking speed with incident knee osteoarthritis-related outcomes.

PubMed

Purser, Jama L; Golightly, Yvonne M; Feng, Qiushi; Helmick, Charles G; Renner, Jordan B; Jordan, Joanne M

2012-07-01

To determine whether slower walking speed was associated with an increased risk of incident hip and knee osteoarthritis (OA)-related outcomes. After providing informed consent, community-dwelling participants in the Johnston County Osteoarthritis Project completed 2 home-based interviews and an additional clinic visit for radiographic and physical evaluation. One thousand eight hundred fifty-eight noninstitutionalized residents ages ≥ 45 years living for at least 1 year in 1 of 6 townships in Johnston County, North Carolina, completed the study's questionnaires and clinical examinations at baseline and at followup testing. Walking time was assessed using a manual stopwatch in 2 trials over an 8-foot distance, and walking speed was calculated as the average of both trials. For the hip and knee, we examined 3 outcomes per joint site: radiographic OA (weight-bearing anteroposterior knee radiographs, supine anteroposterior pelvic radiographs of the hip), chronic joint symptoms, and symptomatic OA. Covariates included age, sex, race, education, marital status, body mass index, number of self-reported chronic conditions diagnosed by a health care provider, number of prescriptions, depressive symptoms, self-rated health, number of lower body functional limitations, smoking, and physical activity. Faster walking speed was consistently associated with a lower incidence of radiographic (adjusted odds ratio [OR] 0.88, 95% confidence interval [95% CI] 0.79-0.97) and symptomatic knee OA (adjusted OR 0.84, 95% CI 0.75-0.95); slower walking speed was associated with a greater incidence of these outcomes across a broad range of different clinical and radiographic OA outcomes. Slower walking speed may be a marker for incident knee OA, but other studies must confirm this finding. Copyright © 2012 by the American College of Rheumatology.

The Rate of Seasonal Changes in Temperature Alters Acclimation of Performance under Climate Change.

PubMed

Nilsson-Örtman, Viktor; Johansson, Frank

2017-12-01

How the ability to acclimate will impact individual performance and ecological interactions under climate change remains poorly understood. Theory predicts that the benefit an organism can gain from acclimating depends on the rate at which temperatures change relative to the time it takes to induce beneficial acclimation. Here, we present a conceptual model showing how slower seasonal changes under climate change can alter species' relative performance when they differ in acclimation rate and magnitude. To test predictions from theory, we performed a microcosm experiment where we reared a mid- and a high-latitude damselfly species alone or together under the rapid seasonality currently experienced at 62°N and the slower seasonality predicted for this latitude under climate change and measured larval growth and survival. To separate acclimation effects from fixed thermal responses, we simulated growth trajectories based on species' growth rates at constant temperatures and quantified how much and how fast species needed to acclimate to match the observed growth trajectories. Consistent with our predictions, the results showed that the midlatitude species had a greater capacity for acclimation than the high-latitude species. Furthermore, since acclimation occurred at a slower rate than seasonal temperature changes, the midlatitude species had a small growth advantage over the high-latitude species under the current seasonality but a greater growth advantage under the slower seasonality predicted for this latitude under climate change. In addition, the two species did not differ in survival under the current seasonality, but the midlatitude species had higher survival under the predicted climate change scenario, possibly because rates of cannibalism were lower when smaller heterospecifics were present. These findings highlight the need to incorporate acclimation rates in ecological models.

Real-time observation of cascaded electronic relaxation processes in p-Fluorotoluene

NASA Astrophysics Data System (ADS)

Hao, Qiaoli; Deng, Xulan; Long, Jinyou; Wang, Yanmei; Abulimiti, Bumaliya; Zhang, Bing

2017-08-01

Ultrafast electronic relaxation processes following two photoexcitation of 400 nm in p-Fluorotoluene (pFT) have been investigated utilizing time-resolved photoelectron imaging coupled with time-resolved mass spectroscopy. Cascaded electronic relaxation processes started from the electronically excited S2 state are directly imaged in real time and well characterized by two distinct time constants of 85 ± 10 fs and 2.4 ± 0.3 ps. The rapid component corresponds to the lifetime of the initially excited S2 state, including the structure relaxation from the Franck-Condon region to the conical intersection of S2/S1 and the subsequent internal conversion to the highly excited S1 state. While, the slower relaxation constant is attributed to the further internal conversion to the high levels of S0 from the secondarily populated S1 locating in the channel three region. Moreover, dynamical differences with benzene and toluene of analogous structures, including, specifically, the slightly slower relaxation rate of S2 and the evidently faster decay of S1, are also presented and tentatively interpreted as the substituent effects. In addition, photoelectron kinetic energy and angular distributions reveal the feature of accidental resonances with low-lying Rydberg states (the 3p, 4s and 4p states) during the multi-photon ionization process, providing totally unexpected but very interesting information for pFT.

Risky business for a juvenile marine predator? Testing the influence of foraging strategies on size and growth rate under natural conditions

PubMed Central

DiBattista, Joseph D.; Moore, Jonathan W.; Ward, Eric J.; Fisk, Aaron T.; Kessel, Steven; Guttridge, Tristan L.; Feldheim, Kevin A.; Franks, Bryan R.; Gruber, Samuel H.; Weideli, Ornella C.; Chapman, Demian D.

2017-01-01

Mechanisms driving selection of body size and growth rate in wild marine vertebrates are poorly understood, thus limiting knowledge of their fitness costs at ecological, physiological and genetic scales. Here, we indirectly tested whether selection for size-related traits of juvenile sharks that inhabit a nursery hosting two dichotomous habitats, protected mangroves (low predation risk) and exposed seagrass beds (high predation risk), is influenced by their foraging behaviour. Juvenile sharks displayed a continuum of foraging strategies between mangrove and seagrass areas, with some individuals preferentially feeding in one habitat over another. Foraging habitat was correlated with growth rate, whereby slower growing, smaller individuals fed predominantly in sheltered mangroves, whereas larger, faster growing animals fed over exposed seagrass. Concomitantly, tracked juveniles undertook variable movement behaviours across both the low and high predation risk habitat. These data provide supporting evidence for the hypothesis that directional selection favouring smaller size and slower growth rate, both heritable traits in this shark population, may be driven by variability in foraging behaviour and predation risk. Such evolutionary pathways may be critical to adaptation within predator-driven marine ecosystems. PMID:28381626

Risky business for a juvenile marine predator? Testing the influence of foraging strategies on size and growth rate under natural conditions.

PubMed

Hussey, Nigel E; DiBattista, Joseph D; Moore, Jonathan W; Ward, Eric J; Fisk, Aaron T; Kessel, Steven; Guttridge, Tristan L; Feldheim, Kevin A; Franks, Bryan R; Gruber, Samuel H; Weideli, Ornella C; Chapman, Demian D

2017-04-12

Mechanisms driving selection of body size and growth rate in wild marine vertebrates are poorly understood, thus limiting knowledge of their fitness costs at ecological, physiological and genetic scales. Here, we indirectly tested whether selection for size-related traits of juvenile sharks that inhabit a nursery hosting two dichotomous habitats, protected mangroves (low predation risk) and exposed seagrass beds (high predation risk), is influenced by their foraging behaviour. Juvenile sharks displayed a continuum of foraging strategies between mangrove and seagrass areas, with some individuals preferentially feeding in one habitat over another. Foraging habitat was correlated with growth rate, whereby slower growing, smaller individuals fed predominantly in sheltered mangroves, whereas larger, faster growing animals fed over exposed seagrass. Concomitantly, tracked juveniles undertook variable movement behaviours across both the low and high predation risk habitat. These data provide supporting evidence for the hypothesis that directional selection favouring smaller size and slower growth rate, both heritable traits in this shark population, may be driven by variability in foraging behaviour and predation risk. Such evolutionary pathways may be critical to adaptation within predator-driven marine ecosystems. © 2017 The Author(s).

Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 Compared to Their Susceptibilities to 11 Other Agents

PubMed Central

Credito, Kim L.; Lin, Gengrong; Pankuch, Glenn A.; Bajaksouzian, Saralee; Jacobs, Michael R.; Appelbaum, Peter C.

2001-01-01

The activity of the ketolide ABT-773 against Haemophilus and Moraxella was compared to those of 11 other agents. Against 210 Haemophilus influenzae strains (39.0% β-lactamase positive), microbroth dilution tests showed that azithromycin and ABT-773 had the lowest MICs (0.5 to 4.0 and 1.0 to 8.0 μg/ml, respectively), followed by clarithromycin and roxithromycin (4.0 to >32.0 μg/ml). Of the β-lactams, ceftriaxone had the lowest MICs (≤0.004 to 0.016 μg/ml), followed by cefixime and cefpodoxime (0.008 to 0.125 and ≤0.125 to 0.25 μg/ml, respectively), amoxicillin-clavulanate (0.125 to 4.0 μg/ml), and cefuroxime (0.25 to 8.0 μg/ml). Amoxicillin was only active against β-lactamase-negative strains, and cefprozil had the highest MICs of all oral cephalosporins tested (0.5 to >32.0 μg/ml). Against 50 Moraxella catarrhalis strains, all of the compounds except amoxicillin and cefprozil were active. Time-kill studies against 10 H. influenzae strains showed that ABT-773, at two times the MIC, was bactericidal against 9 of 10 strains, with 99% killing of all strains at the MIC after 24 h; at 12 h, ABT-773 gave 90% killing of all strains at two times the MIC. At 3 and 6 h, killing by ABT-773 was slower, with 99.9% killing of four strains at two times the MIC after 6 h. Similar results were found for azithromycin, with slightly slower killing by erythromycin, clarithromycin, and roxithromycin, especially at earlier times. β-Lactams were bactericidal against 8 to 10 strains at two times the MIC after 24 h, with slower killing at earlier time periods. Most compounds gave good killing of five M. catarrhalis strains, with β-lactams killing more rapidly than other drugs. ABT-773 and azithromycin gave the longest postantibiotic effects (PAEs) of the ketolide-macrolide-azalide group tested (4.4 to >8.0 h), followed by clarithromycin, erythromycin, and roxithromycin. β-Lactam PAEs were similar and shorter than those of the ketolide-macrolide-azalide group for all strains tested. PMID:11120946

Discriminative evaluative conditioning in the long-term after severe accidental injury.

PubMed

Oe, Misari; Schumacher, Sonja; Schnyder, Ulrich; Mueller-Pfeiffer, Christoph; Wilhelm, Frank H; Kuelen, Eveline; Martin-Soelch, Chantal

2016-06-30

Impairments in classical fear conditioning and deficits in discriminative learning are observed in posttraumatic stress disorder (PTSD). However, it is unknown whether similar impairments can be found with types of discriminative learning other than classical conditioning, such as evaluative conditioning (EC), in which the valence of a stimulus can be transferred to other stimuli. In this study, we investigated whether EC is also influenced by traumatic experiences independently of presence of PTSD. We tested 14 accident survivors with remitted PTSD, 14 survivors without PTSD, and 16 non-trauma controls. We used behavioral measures, psychophysiological indicators, and subjective ratings for tasks. General effects of learning were observed across groups and conditioning/extinction. Trauma controls had slower reaction times (RTs) to the aversive conditioned stimulus compared to appetitive conditioned and neutral stimuli, as well as slower RTs and increased accuracy during conditioning than during extinction. Remitted PTSD participants showed opposite results, demonstrating decreased accuracy and slower RTs during conditioning as compared to during extinction. No discriminative effect was found in the non-trauma controls and the remitted PTSD participants. These results suggest that a traumatic experience influences EC, and that this influence differs between individuals who have and have not developed PTSD after traumatic exposure. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Effects of Cascaded Voltage Collapse and Protection of Many Induction Machine Loads upon Load Characteristics Viewed from Bulk Transmission System

NASA Astrophysics Data System (ADS)

Kumano, Teruhisa

As known well, two of the fundamental processes which give rise to voltage collapse in power systems are the on load tap changers of transformers and dynamic characteristics of loads such as induction machines. It has been well established that, comparing among these two, the former makes slower collapse while the latter makes faster. However, in realistic situations, the load level of each induction machine is not uniform and it is well expected that only a part of loads collapses first, followed by collapse process of each load which did not go into instability during the preceding collapses. In such situations the over all equivalent collapse behavior viewed from bulk transmission level becomes somewhat different from the simple collapse driven by one aggregated induction machine. This paper studies the process of cascaded voltage collapse among many induction machines by time simulation, where load distribution on a feeder line is modeled by several hundreds of induction machines and static impedance loads. It is shown that in some cases voltage collapse really cascades among induction machines, where the macroscopic load dynamics viewed from upper voltage level makes slower collapse than expected by the aggregated load model. Also shown is the effects of machine protection of induction machines, which also makes slower collapse.

Direct observation of the photodegradation of anthracene and pyrene adsorbed onto mangrove leaves.

PubMed

Wang, Ping; Wu, Tun-Hua; Zhang, Yong

2014-01-01

An established synchronous fluorimetry method was used for in situ investigation of the photodegradation of pyrene (PYR) and anthracene (ANT) adsorbed onto fresh leaves of the seedlings of two mangrove species, Aegiceras corniculatum (L.) Blanco (Ac) and Kandelia obovata (Ko) in multicomponent mixtures (mixture of the ANT and PYR). Experimental results indicated that photodegradation was the main transformation pathway for both ANT and PYR in multicomponent mixtures. The amount of the PAHs volatilizing from the leaf surfaces and entering the inner leaf tissues was negligible. Over a certain period of irradiation time, the photodegradation of both PYR and ANT adsorbed onto the leaves of Ac and Ko followed first-order kinetics, with faster rates being observed on Ac leaves. In addition, the photodegradation rate of PYR on the leaves of the mangrove species in multicomponent mixtures was much slower than that of adsorbed ANT. Compared with the PAHs adsorbed as single component, the photodegradation rate of ANT adsorbed in multicomponent mixtures was slower, while that of PYR was faster. Moreover, the photodegradation of PYR and ANT dissolved in water in multicomponent mixtures was investigated for comparison. The photodegradation rate on leaves was much slower than in water. Therefore, the physical-chemical properties of the substrate may strongly influence the photodegradation rate of adsorbed PAHs.

Direct Observation of the Photodegradation of Anthracene and Pyrene Adsorbed onto Mangrove Leaves

PubMed Central

Wang, Ping; Wu, Tun-Hua; Zhang, Yong

2014-01-01

An established synchronous fluorimetry method was used for in situ investigation of the photodegradation of pyrene (PYR) and anthracene (ANT) adsorbed onto fresh leaves of the seedlings of two mangrove species, Aegiceras corniculatum (L.) Blanco (Ac) and Kandelia obovata (Ko) in multicomponent mixtures (mixture of the ANT and PYR). Experimental results indicated that photodegradation was the main transformation pathway for both ANT and PYR in multicomponent mixtures. The amount of the PAHs volatilizing from the leaf surfaces and entering the inner leaf tissues was negligible. Over a certain period of irradiation time, the photodegradation of both PYR and ANT adsorbed onto the leaves of Ac and Ko followed first-order kinetics, with faster rates being observed on Ac leaves. In addition, the photodegradation rate of PYR on the leaves of the mangrove species in multicomponent mixtures was much slower than that of adsorbed ANT. Compared with the PAHs adsorbed as single component, the photodegradation rate of ANT adsorbed in multicomponent mixtures was slower, while that of PYR was faster. Moreover, the photodegradation of PYR and ANT dissolved in water in multicomponent mixtures was investigated for comparison. The photodegradation rate on leaves was much slower than in water. Therefore, the physical-chemical properties of the substrate may strongly influence the photodegradation rate of adsorbed PAHs. PMID:25144741

Scaling of ion expansion energy with laser flux in moderate-Z plasmas produced by lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, P.D.; Goel, S.K.; Uppal, J.S.

1982-09-01

Ion expansion energy measurements in plasmas created by focusing 1-GW, 5-nsec Nd:glass laser on plane solid targets of polythene, carbon, and aluminum are reported. It is observed that the scaling of ion expansion energy with laser flux Phi varies between Phi/sup 0.28/ and Phi/sup 0.66/ for polythene, Phi/sup 0.28/ and Phi/sup 0.70/ for carbon, and Phi/sup 0.51/ and Phi/sup 0.44/ for aluminum in the flux range 5 x 10/sup 10/--5 x 10/sup 12/ W/cm/sup 2/ of our experiment. The scaling is either much slower or faster than a scaling of Phi/sup 4/9/ expected from a self-regulating model for plasmas createdmore » in the low flux range. It is shown that this behavior, as well as results of experiments on similar plasmas reported by other authors, can be explained when radiation losses and the energy spent in ionization are also considered in the self-regulating model.« less

Effect of a concurrent auditory task on visual search performance in a driving-related image-flicker task.

PubMed

Richard, Christian M; Wright, Richard D; Ee, Cheryl; Prime, Steven L; Shimizu, Yujiro; Vavrik, John

2002-01-01

The effect of a concurrent auditory task on visual search was investigated using an image-flicker technique. Participants were undergraduate university students with normal or corrected-to-normal vision who searched for changes in images of driving scenes that involved either driving-related (e.g., traffic light) or driving-unrelated (e.g., mailbox) scene elements. The results indicated that response times were significantly slower if the search was accompanied by a concurrent auditory task. In addition, slower overall responses to scenes involving driving-unrelated changes suggest that the underlying process affected by the concurrent auditory task is strategic in nature. These results were interpreted in terms of their implications for using a cellular telephone while driving. Actual or potential applications of this research include the development of safer in-vehicle communication devices.

Inhibition of Return in Response to Eye Gaze and Peripheral Cues in Young People with Asperger's Syndrome

ERIC Educational Resources Information Center

Marotta, Andrea; Pasini, Augusto; Ruggiero, Sabrina; Maccari, Lisa; Rosa, Caterina; Lupianez, Juan; Casagrande, Maria

2013-01-01

Inhibition of return (IOR) reflects slower reaction times to stimuli presented in previously attended locations. In this study, we examined this inhibitory after-effect using two different cue types, eye-gaze and standard peripheral cues, in individuals with Asperger's syndrome and typically developing individuals. Typically developing…

Computers and the supply of radiology services: anatomy of a disruptive technology.

PubMed

Levy, Frank

2008-10-01

Over the next decade, computers will augment the supply of radiology services at a time when reimbursement rules are likely to tighten. Increased supply and slower growing demand will result in a radiology market that is more competitive, with less income growth, than the market of the past 15 years.

The missing mountain water: Slower westerlies decrease orographic enhancement in the Pacific Northwest USA

Treesearch

C. H. Luce; J. T. Abatzoglou; Z. A. Holden

2013-01-01

Trends in streamflow timing and volume in the Pacific Northwest United States have been attributed to increased temperatures because trends in precipitation at lower elevation stations were negligible. We demonstrate that observed streamflow declines likely are associated with declines in mountain precipitation, revealing previously unexplored differential trends....

The Development of Rhythmic Attending in Auditory Sequences: Attunement, Referent Period, Focal Attending.

ERIC Educational Resources Information Center

Drake, Carolyn; Jones, Mari Riess; Baruch, Clarisse

2000-01-01

Extends dynamic attending theory to developmental questions concerning tempo and time hierarchies. Compares performance of 4- to 10-year-olds, and adults on dynamic attending activities. Suggests that growth trends could be expressed in terms of listeners' engagement of slower attending oscillators with age and musical experience, accompanied by…

Impaired Visual Attention in Children with Dyslexia.

ERIC Educational Resources Information Center

Heiervang, Einar; Hugdahl, Kenneth

2003-01-01

A cue-target visual attention task was administered to 25 children (ages 10-12) with dyslexia. Results showed a general pattern of slower responses in the children with dyslexia compared to controls. Subjects also had longer reaction times in the short and long cue-target interval conditions (covert and overt shift of attention). (Contains…

How Fast Does a Building Fall?

ERIC Educational Resources Information Center

Denny, Mark

2010-01-01

In this paper, the time required for a tower block to collapse is calculated. The tower collapses progressively, with one floor falling onto the floor below, causing it to fall. The rate of collapse is found to be not much slower than freefall. The calculation is an engaging and relevant application of Newton's laws, suitable for undergraduate…

Study on the polarization scrambling time for ultra-high-speed optical fiber communication systems

NASA Astrophysics Data System (ADS)

Jia, Nan; Li, Tangjun; Zhong, Kangping; Gong, Taorong; Lu, Dan; Chen, Ming; Wang, Chen

2009-11-01

A 160Gbit/s optical time-division-multiplexing (OTDM) transmission system with polarization Scrambler is demonstrated experimentally. The Scrambler based on the structure of the all-fiber dynamic polarization controller (PolaRITE II by General Photonics Co.). The polarization controller is controlled accurately the peak scrambling frequencies and the corresponding half-wave voltages by home-made a singlechip circuit. Both theory and experience show that the rate of scrambler is related to the spectrum width, spectral distribution, modulation rate and so on. The rate of Scramble for broadband light would be much slower compare with narrowband light to carrying out depolarization. In the same width of spectrum, light with abundant spectrum would need a slower rate. The relationship between the Rate of Scrambler and the Character of different Lasers will be discussed by using Stokes parameters and Mueller matrix. And the experiments performed to verify the results of theoretical analysis results. The Scrambler can reduce Intersymbol Interference, Polarization Mode Dispersion (PMD) and Polarization Dependent Loss (PDL) that have are validated experimentally. Based on the Scrambler, the 160-Gb/s OTDM transmissions are successfully demonstrated.

Ocean Surface Wave Optical Roughness: Analysis of Innovative Measurements

DTIC Science & Technology

2013-12-16

relationship of MSS to wind speed, and at times has shown a reversal of the Cox-Munk linear relationship. Furthermore, we observe measurable changes in...1985]. The variable speed allocation method has the effect of aliasing (cb) to slower waves, thereby increasing the exponent –m. Our analysis based ...RaDyO) program. The primary research goals of the program are to (1) examine time -dependent oceanic radiance distribution in relation to dynamic

Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease

PubMed Central

Neumann, Wolf-Julian; Bock, Antje; Horn, Andreas; Huebl, Julius; Siegert, Sandy; Schneider, Gerd-Helge; Krauss, Joachim K

2018-01-01

Gamma synchronization increases during movement and scales with kinematic parameters. Here, disease-specific characteristics of this synchronization and the dopamine-dependence of its scaling in Parkinson’s disease are investigated. In 16 patients undergoing deep brain stimulation surgery, movements of different velocities revealed that subthalamic gamma power peaked in the sensorimotor part of the subthalamic nucleus, correlated positively with maximal velocity and negatively with symptom severity. These effects relied on movement-related bursts of transient synchrony in the gamma band. The gamma burst rate highly correlated with averaged power, increased gradually with larger movements and correlated with symptom severity. In the dopamine-depleted state, gamma power and burst rate significantly decreased, particularly when peak velocity was slower than ON medication. Burst amplitude and duration were unaffected by the medication state. We propose that insufficient recruitment of fast gamma bursts during movement may underlie bradykinesia as one of the cardinal symptoms in Parkinson’s disease. PMID:29388913

Mean field model of acetylcholine mediated dynamics in the cerebral cortex.

PubMed

Clearwater, J M; Rennie, C J; Robinson, P A

2007-12-01

A recent continuum model of the large scale electrical activity of the cerebral cortex is generalized to include cholinergic modulation. In this model, dynamic modulation of synaptic strength acts over the time scales of nicotinic and muscarinic receptor action. The cortical model is analyzed to determine the effect of acetylcholine (ACh) on its steady states, linear stability, spectrum, and temporal responses to changes in subcortical input. ACh increases the firing rate in steady states of the system. Changing ACh concentration does not introduce oscillatory behavior into the system, but increases the overall spectral power. Model responses to pulses in subcortical input are affected by the tonic level of ACh concentration, with higher levels of ACh increasing the magnitude firing rate response of excitatory cortical neurons to pulses of subcortical input. Numerical simulations are used to explore the temporal dynamics of the model in response to changes in ACh concentration. Evidence is seen of a transition from a state in which intracortical inputs are emphasized to a state where thalamic afferents have enhanced influence. Perturbations in ACh concentration cause changes in the firing rate of cortical neurons, with rapid responses due to fast acting facilitatory effects of nicotinic receptors on subcortical afferents, and slower responses due to muscarinic suppression of intracortical connections. Together, these numerical simulations demonstrate that the actions of ACh could be a significant factor modulating early components of evoked response potentials.

Synthesis and Performance Characterization of a Nanocomposite Ternary Thermite: Al/Fe2O3/SiO2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prentice, D; Pantoya, M L; Clapsaddle, B J

2005-02-04

Making solid energetic materials requires the physical mixing of solid fuels and oxidizers or the incorporation of fuel and oxidizing moieties into a single molecule. The former are referred to as composite energetic materials (i.e., thermites, propellants, pyrotechnics) and the latter are deemed monomolecular energetic materials (i.e., explosives). Mass diffusion between the fuel and oxidizer is the rate controlling step for composite reactions while bond breaking and chemical kinetics control monomolecular reactions. Although composites have higher energy densities than monomolecular species, they release that energy over a longer period of time because diffusion controlled reactions are considerably slower than chemistrymore » controlled reactions. Conversely, monomolecular species exhibit greater power due to more rapid kinetics than physically mixed energetics. Reducing the diffusion distance between fuel and oxidizer species within an energetic composite would enhance the reaction rate. Recent advances in nanotechnology have spurred the development of nano-scale fuel and oxidizer particles that can be combined into a composite and effectively reduce diffusion distances to nano-scale dimensions or less. These nanocomposites have the potential to deliver the best of both worlds: high energy density of the physically mixed composite with the high power of the monomolecular species. Toward this end, researchers at Lawrence Livermore National Laboratory (LLNL) developed nano-particle synthesis techniques, based on sol-gel chemistry, for the production of thermite nanocomposites.« less

Halo abundance and assembly history with extreme-axion wave dark matter at z ≥ 4

NASA Astrophysics Data System (ADS)

Schive, Hsi-Yu; Chiueh, Tzihong

2018-01-01

Wave dark matter (ψDM) composed of extremely light bosons (mψ ˜ 10 - 22 eV), with quantum pressure suppressing structures below a kpc-scale de Broglie wavelength, has become a viable dark matter candidate. Compared to the conventional free-particle ψDM (FPψDM), the extreme-axion ψDM model (EAψDM) proposed by Zhang & Chiueh features a larger cut-off wavenumber and a broad spectral bump in the matter transfer function. Here, we conduct cosmological simulations to compare the halo abundances and assembly histories at z = 4-11 between three different scenarios: FPψDM, EAψDM and cold dark matter (CDM). We show that EAψDM produces significantly more abundant low-mass haloes than FPψDM with the same mψ, and therefore could alleviate the tension in mψ required by the Lyα forest data and by the kpc-scale dwarf galaxy cores. We also find that, compared to the CDM counterparts, massive EAψDM haloes are, on average, 3-4 times more massive at z = 10-11 due to their earlier formation, undergo a slower mass accretion at 7 ≲ z ≲ 11, and then show a rapidly rising major merger rate exceeding CDM by ˜ 50 per cent at 4 ≲ z ≲ 7. This fact suggests that EAψDM haloes may exhibit more prominent starbursts at z ≲ 7.

Design of a Permanent-Magnet Zeeman Slower

NASA Astrophysics Data System (ADS)

Adler, Charles; Narducci, Frank; Sukenik, Charles; Mulholland, Jonathan; Goodale, Sarah

2006-05-01

During the past decade, low cost, flexible, and highly-polarized magnetic field sheet material has become available with field strengths useful for applications in modern atomic physics experiments. One advantage of using such material is that it can easily be cut to almost any desired shape without appreciable loss of field strength making it more versatile than ceramic magnets. We present the design of a Zeeman slower, made from such material, for cooling an atomic beam of neutral rubidium atoms and discuss results from an atomic beam trajectory simulation which indicates that the slower should perform well. We will also report on progress of a prototype permanent magnet Zeeman slower presently under construction in the laboratory.

Electronic and molecular structure of carbon grains

NASA Technical Reports Server (NTRS)

Almloef, Jan; Luethi, Hans-Peter

1990-01-01

Clusters of carbon atoms have been studied with large-scale ab initio calculations. Planar, single-sheet graphite fragments with 6 to 54 atoms were investigated, as well as the spherical C(sub 60) Buckminsterfullerene molecule. Polycyclic aromatic hydrocarbons (PAHs) have also been considered. Thermodynamic differences between diamond- and graphite-like grains have been studied in particular. Saturation of the peripheral bonds with hydrogen is found to provide a smooth and uniform convergence of the properties with increasing cluster size. For the graphite-like clusters the convergence to bulk values is much slower than for the three-dimensional complexes.

Testing of models of VVH particle sources and propagation

NASA Technical Reports Server (NTRS)

Blanford, G. E., Jr.; Friedlander, M. W.; Hoppe, M.; Klarmann, J.; Walker, R. M.; Wefel, J. P.

1974-01-01

For comparisons between theoretical and observed charge spectra of VVH particles to be meaningful, at least two conditions must be met. First, charge resolution must be adequate to separate important groups of nuclei, and there should be no significant systematic errors in the charge scale developed. Second, there must be adequate rejection of slower particles of smaller Z, which have been observed in several flights. Within these conditions, it has been shown that observed features of the charge spectrum are not accidents of the analysis but reflect real variations in the relative abundances that must be explained by any successful model.

A Investigation of the Verbal Description of Trombone Tone Quality with Respect to Selected Attributes of Sound

NASA Astrophysics Data System (ADS)

Stroeher, Michael Steven

The purpose of this study was to determine the physical elements which experienced trombonists associate with selected descriptors in characterizing the tone quality of that instrument. Stimuli sampled from live trombone tones and synthesized into musical phrases represented 17 variations in (1) presence/absence of attack transient, (2) rise time, (3) duration, (4) number of harmonics, (5) upper limit of harmonicity, (6) spectral envelope shape, and (7) frequency. A vocabulary of 20 adjectives appropriate for describing trombone tone quality was established by a postal survey of 49 college trombone instructors. A pretest was presented to 28 University of North Texas trombone students, who rated the 17 stimuli in terms of the 20 adjectives on a Likert-type scale with reliability estimates of.8997 to.9439 (coefficient alpha). The pretest established the lack of significance of the attack transient in subjects' descriptions. Factor analysis of responses determined similarities in word usages and allowed the number of descriptors to be reduced to eight and the number of sound stimuli to nine for the final investigation. Subjects of the final study consisted of 161 trombonists at universities in Texas, Oklahoma, Colorado, Michigan and North Carolina, who rated the nine stimuli in terms of the eight chosen adjectives on Likert-type scales, with an overall reliability estimate of.7121 (coefficient alpha). Although the low reliability indicated some lack of agreement in descriptor usage, multiple regression analysis established relationships among subjects' use of descriptors and physical attributes of the stimuli. Subjects' judgements of bright were associated with tones of higher frequency; centered, good, dark and warm with faster rise time, longer duration and relatively fewer harmonics; pinched with a high number of harmonics and slower rise time; fuzzy with slow rise time and the presence of high-frequency inharmonic noise. Subjects did not use the word full with any degree of consistency.

Qubit-qubit interaction in quantum computers: errors and scaling laws

NASA Astrophysics Data System (ADS)

Gea-Banacloche, Julio R.

1998-07-01

This paper explores the limitations that interaction between the physical qubits making up a quantum computer may impose on the computer's performance. For computers using atoms as qubits, magnetic dipole-dipole interactions are likely to be dominant; various types of errors which they might introduce are considered here. The strength of the interaction may be reduce by increasing the distance between qubits, which in general will make the computer slower. For ion-chain based quantum computers the slowing down due to this effect is found to be generally more sever than that due to other causes. In particular, this effect alone would be enough to make these systems unacceptably slow for large-scale computation, whether they use the center of mass motion as the 'bus' or whether they do this via an optical cavity mode.

Exercise improves gait, reaction time and postural stability in older adults with type 2 diabetes and neuropathy.

PubMed

Morrison, Steven; Colberg, Sheri R; Parson, Henri K; Vinik, Aaron I

2014-01-01

For older adults with type 2 diabetes (T2DM), declines in balance and walking ability are risk factors for falls, and peripheral neuropathy magnifies this risk. Exercise training may improve balance, gait and reduce the risk of falling. This study investigated the effects of 12weeks of aerobic exercise training on walking, balance, reaction time and falls risk metrics in older T2DM individuals with/without peripheral neuropathy. Adults with T2DM, 21 without (DM; age 58.7±1.7years) and 16 with neuropathy (DM-PN; age 58.9±1.9years), engaged in either moderate or intense supervised exercise training thrice-weekly for 12weeks. Pre/post-training assessments included falls risk (using the physiological profile assessment), standing balance, walking ability and hand/foot simple reaction time. Pre-training, the DM-PN group had higher falls risk, slower (hand) reaction times (232 vs. 219ms), walked at a slower speed (108 vs. 113cm/s) with shorter strides compared to the DM group. Following training, improvements in hand/foot reaction times and faster walking speed were seen for both groups. While falls risk was not significantly reduced, the observed changes in gait, reaction time and balance metrics suggest that aerobic exercise of varying intensities is beneficial for improving dynamic postural control in older T2DM adults with/without neuropathy. Copyright © 2014 Elsevier Inc. All rights reserved.

Sensorimotor Peripheral Nerve Function and the Longitudinal Relationship with Endurance Walking in the Health, Aging and Body Composition Study

PubMed Central

Lange-Maia, Brittney S.; Newman, Anne B.; Cauley, Jane A.; Boudreau, Robert M.; Jakicic, John M.; Caserotti, Paolo; Glynn, Nancy W.; Harris, Tamara B.; Kritchevsky, Stephen B.; Schwartz, Ann V.; Satterfield, Suzanne; Simonsick, Eleanor M.; Vinik, Aaron I.; Zivkovic, Sasa; Strotmeyer, Elsa S.

2015-01-01

Objectives To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. Design Prospective cohort study with six years of follow-up. Setting Two U.S. clinical sites in (Pittsburgh, PA and Memphis, TN). Participants Community-dwelling older adults enrolled in Health, Aging and Body Composition study from the 2000/01 annual clinical examination (n=2393; age 76.5 ± 2.9 years; 48.2% male; 38.2% black) and subset with longitudinal data (n=1,178). Interventions Not applicable Main Outcome Measures Participants underwent peripheral nerve function examination in 2000/01, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower-extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The long distance corridor walk (LDCW; 400m) was administered in 2000/01 and every two years afterwards for 6 years to assess endurance walking performance over time. Results In separate fully adjusted linear mixed models poor vibration threshold (>130 microns), 10-g and 1.4-g monofilament insensitivity were each associated with slower LDCW completion time (16.0, 14.1, and 6.7, seconds slower, respectively, P<.05 for each). Poor motor amplitude (<1mV), poor vibration perception threshold, and 10-g monofilament insensitivity were related to greater slowing/year (4.7, 4.3, and 4.3 additional seconds/year, respectively, P<.05), though poor motor amplitude was not associated with initial completion time. Conclusions Poorer sensorimotor peripheral nerve function is related to slower endurance walking and greater slowing longitudinally. Interventions to reduce the burden of sensorimotor peripheral nerve function impairments should be considered in order to help older adults to maintain walking endurance—a critical component for remaining independent in the community. PMID:26343170

Robotic gaming prototype for upper limb exercise: Effects of age and embodiment on user preferences and movement.

PubMed

Eizicovits, Danny; Edan, Yael; Tabak, Iris; Levy-Tzedek, Shelly

2018-01-01

Effective human-robot interactions in rehabilitation necessitates an understanding of how these should be tailored to the needs of the human. We report on a robotic system developed as a partner on a 3-D everyday task, using a gamified approach. To: (1) design and test a prototype system, to be ultimately used for upper-limb rehabilitation; (2) evaluate how age affects the response to such a robotic system; and (3) identify whether the robot's physical embodiment is an important aspect in motivating users to complete a set of repetitive tasks. 62 healthy participants, young (<30 yo) and old (>60 yo), played a 3D tic-tac-toe game against an embodied (a robotic arm) and a non-embodied (a computer-controlled lighting system) partner. To win, participants had to place three cups in sequence on a physical 3D grid. Cup picking-and-placing was chosen as a functional task that is often practiced in post-stroke rehabilitation. Movement of the participants was recorded using a Kinect camera. The timing of the participants' movement was primed by the response time of the system: participants moved slower when playing with the slower embodied system (p = 0.006). The majority of participants preferred the robot over the computer-controlled system. Slower response time of the robot compared to the computer-controlled one only affected the young group's motivation to continue playing. We demonstrated the feasibility of the system to encourage the performance of repetitive 3D functional movements, and track these movements. Young and old participants preferred to interact with the robot, compared with the non-embodied system. We contribute to the growing knowledge concerning personalized human-robot interactions by (1) demonstrating the priming of the human movement by the robotic movement - an important design feature, and (2) identifying response-speed as a design variable, the importance of which depends on the age of the user.

Singularities in Dromo formulation. Analysis of deep flybys

NASA Astrophysics Data System (ADS)

Roa, Javier; Sanjurjo-Rivo, Manuel; Peláez, Jesús

2015-08-01

The singularities in Dromo are characterized in this paper, both from an analytical and a numerical perspective. When the angular momentum vanishes, Dromo may encounter a singularity in the evolution equations. The cancellation of the angular momentum occurs in very specific situations and may be caused by the action of strong perturbations. The gravitational attraction of a perturbing planet may lead to rapid changes in the angular momentum of the particle. In practice, this situation may be encountered during deep planetocentric flybys. The performance of Dromo is evaluated in different scenarios. First, Dromo is validated for integrating the orbit of Near Earth Asteroids. Resulting errors are of the order of the diameter of the asteroid. Second, a set of theoretical flybys are designed for analyzing the performance of the formulation in the vicinity of the singularity. New sets of Dromo variables are proposed in order to minimize the dependency of Dromo on the angular momentum. A slower time scale is introduced, leading to a more stable description of the flyby phase. Improvements in the overall performance of the algorithm are observed when integrating orbits close to the singularity.

Towards Scalable Graph Computation on Mobile Devices.

PubMed

Chen, Yiqi; Lin, Zhiyuan; Pienta, Robert; Kahng, Minsuk; Chau, Duen Horng

2014-10-01

Mobile devices have become increasingly central to our everyday activities, due to their portability, multi-touch capabilities, and ever-improving computational power. Such attractive features have spurred research interest in leveraging mobile devices for computation. We explore a novel approach that aims to use a single mobile device to perform scalable graph computation on large graphs that do not fit in the device's limited main memory, opening up the possibility of performing on-device analysis of large datasets, without relying on the cloud. Based on the familiar memory mapping capability provided by today's mobile operating systems, our approach to scale up computation is powerful and intentionally kept simple to maximize its applicability across the iOS and Android platforms. Our experiments demonstrate that an iPad mini can perform fast computation on large real graphs with as many as 272 million edges (Google+ social graph), at a speed that is only a few times slower than a 13″ Macbook Pro. Through creating a real world iOS app with this technique, we demonstrate the strong potential application for scalable graph computation on a single mobile device using our approach.

Tracer-tracer relationships and lower stratospheric dynamics: CO2 and N2O correlations during SPADE

NASA Technical Reports Server (NTRS)

Boering, Kristie A.; Daube, Bruce C.; Wofsy, Steven C.; Loewenstein, Max; Podolske, James R.; Keim, Eric R.

1994-01-01

Simultaneous measurements of CO2 and N2O from the NASA ER-2 aircraft during SPADE deployments in November 1992, April/May 1993, and October 1993 provide new information on transport rates in the lower stratosphere. The tropospheric seasonal cycle in CO2, superimposed on the long-term trend, is observed to propagate into the statosphere. The compact correlations observed between CO2 and N2O indicate that meridional transport is sufficiently rapid to create a uniform set of relationships over the northern hemisphere up to at least 21 km even though CO2 changes significantly on a time scale of 8 to 12 weeks. the observed seasonal dependence of the correlations indicates that vertical transport above 20 km is slower in northern summer than in winter and slow throughout the year between 19 km and the tropopause. The inferred amplitude of the seasonal CO2 oscillation in the statopshere, viewed relative to N2O, places constraints on the mean latitude for air entering the statosphere.

Structural predictor for nonlinear sheared dynamics in simple glass-forming liquids

NASA Astrophysics Data System (ADS)

Ingebrigtsen, Trond S.; Tanaka, Hajime

2018-01-01

Glass-forming liquids subjected to sufficiently strong shear universally exhibit striking nonlinear behavior; for example, a power-law decrease of the viscosity with increasing shear rate. This phenomenon has attracted considerable attention over the years from both fundamental and applicational viewpoints. However, the out-of-equilibrium and nonlinear nature of sheared fluids have made theoretical understanding of this phenomenon very challenging and thus slower to progress. We find here that the structural relaxation time as a function of the two-body excess entropy, calculated for the extensional axis of the shear flow, collapses onto the corresponding equilibrium curve for a wide range of pair potentials ranging from harsh repulsive to soft and finite. This two-body excess entropy collapse provides a powerful approach to predicting the dynamics of nonequilibrium liquids from their equilibrium counterparts. Furthermore, the two-body excess entropy scaling suggests that sheared dynamics is controlled purely by the liquid structure captured in the form of the two-body excess entropy along the extensional direction, shedding light on the perplexing mechanism behind shear thinning.

How internal drainage affects evaporation dynamics from soil surfaces ?

NASA Astrophysics Data System (ADS)

Or, D.; Lehmann, P.; Sommer, M.

2017-12-01

Following rainfall, infiltrated water may be redistributed internally to larger depths or lost to the atmosphere by evaporation (and by plant uptake from depths at longer time scales). A large fraction of evaporative losses from terrestrial surfaces occurs during stage1 evaporation during which phase change occurs at the wet surface supplied by capillary flow from the soil. Recent studies have shown existence of a soil-dependent characteristic length below which capillary continuity is disrupted and a drastic shift to slower stage 2 evaporation ensues. Internal drainage hastens this transition and affect evaporative losses. To predict the transition to stage 2 and associated evaporative losses, we developed an analytical solution for evaporation dynamics with concurrent internal drainage. Expectedly, evaporative losses are suppressed when drainage is considered to different degrees depending on soil type and wetness. We observe that high initial water content supports rapid drainage and thus promotes the sheltering of soil water below the evaporation depth. The solution and laboratory experiments confirm nonlinear relationship between initial water content and total evaporative losses. The concept contributes to establishing bounds on regional surface evaporation considering rainfall characteristics and soil types.

Structural predictor for nonlinear sheared dynamics in simple glass-forming liquids.

PubMed

Ingebrigtsen, Trond S; Tanaka, Hajime

2018-01-02

Glass-forming liquids subjected to sufficiently strong shear universally exhibit striking nonlinear behavior; for example, a power-law decrease of the viscosity with increasing shear rate. This phenomenon has attracted considerable attention over the years from both fundamental and applicational viewpoints. However, the out-of-equilibrium and nonlinear nature of sheared fluids have made theoretical understanding of this phenomenon very challenging and thus slower to progress. We find here that the structural relaxation time as a function of the two-body excess entropy, calculated for the extensional axis of the shear flow, collapses onto the corresponding equilibrium curve for a wide range of pair potentials ranging from harsh repulsive to soft and finite. This two-body excess entropy collapse provides a powerful approach to predicting the dynamics of nonequilibrium liquids from their equilibrium counterparts. Furthermore, the two-body excess entropy scaling suggests that sheared dynamics is controlled purely by the liquid structure captured in the form of the two-body excess entropy along the extensional direction, shedding light on the perplexing mechanism behind shear thinning.