13 CFR 120.880 - Basic eligibility requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... 120.880 Section 120.880 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.880 Basic eligibility... for a 504 loan, a small business must: (a) Use the Project Property (except that an Eligible Passive...

13 CFR 120.880 - Basic eligibility requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... 120.880 Section 120.880 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.880 Basic eligibility... for a 504 loan, a small business must: (a) Use the Project Property (except that an Eligible Passive...

13 CFR 120.880 - Basic eligibility requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... 120.880 Section 120.880 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.880 Basic eligibility... for a 504 loan, a small business must: (a) Use the Project Property (except that an Eligible Passive...

10 CFR 431.445 - Determination of small electric motor efficiency.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) General requirements. The average full-load efficiency of each basic model of small electric motor must be... this section, provided, however, that an AEDM may be used to determine the average full-load efficiency of one or more of a manufacturer's basic models only if the average full-load efficiency of at least...

10 CFR 431.445 - Determination of small electric motor efficiency.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) General requirements. The average full-load efficiency of each basic model of small electric motor must be... this section, provided, however, that an AEDM may be used to determine the average full-load efficiency of one or more of a manufacturer's basic models only if the average full-load efficiency of at least...

Environment parameters and basic functions for floating-point computation

NASA Technical Reports Server (NTRS)

Brown, W. S.; Feldman, S. I.

1978-01-01

A language-independent proposal for environment parameters and basic functions for floating-point computation is presented. Basic functions are proposed to analyze, synthesize, and scale floating-point numbers. The model provides a small set of parameters and a small set of axioms along with sharp measures of roundoff error. The parameters and functions can be used to write portable and robust codes that deal intimately with the floating-point representation. Subject to underflow and overflow constraints, a number can be scaled by a power of the floating-point radix inexpensively and without loss of precision. A specific representation for FORTRAN is included.

Antitumor effects of cationic synthetic peptides derived from Lys49 phospholipase A2 homologues of snake venoms.

PubMed

Araya, Cindy; Lomonte, Bruno

2007-03-01

The effects of two cationic synthetic peptides, derived from the C-terminal region of Lys49 phospholipase A2 homologues from snake venoms, upon various murine tumor cell lines (B16 melanoma, EMT6 mammary carcinoma, S-180 sarcoma, P3X myeloma, tEnd endothelial cells) were evaluated. The peptides are 13-mers derived from Agkistrodon piscivorus piscivorus Lys49 PLA2 (p-AppK: KKYKAYFKLKCKK) and Bothrops asper Lys49 myotoxin II (pEM-2[D]: KKWRWWLKALAKK), respectively, in the latter case with slight modifications and with all-D amino acids. All tumor cells tested were susceptible to the lytic action of the peptides. The susceptibility of tumor cell lines was not higher than that of C2C12 skeletal muscle myoblasts, utilized as a non-transformed cell line control. However, in a murine model of subcutaneous solid tumor growth of EMT6 mammary carcinoma, the intraperitoneal administration of pEM-2[D] caused a tumor mass reduction of 36% (p<0.05), which was of similar magnitude to that achieved by the administration of paclitaxel, an antitumor drug in clinical use. Thus, the C-terminal peptides of Lys49 phospholipase A2 homologues present antitumor effects that might be of interest in developing therapeutic strategies against cancer.

Organic synthesis toward small-molecule probes and drugs

PubMed Central

Schreiber, Stuart L.

2011-01-01

“Organic synthesis” is a compound-creating activity often focused on biologically active small molecules. This special issue of PNAS explores innovations and trends in the field that are enabling the synthesis of new types of small-molecule probes and drugs. This perspective article frames the research described in the special issue but also explores how these modern capabilities can both foster a new and more extensive view of basic research in the academy and promote the linkage of life-science research to the discovery of novel types of small-molecule therapeutics [Schreiber SL (2009) Chem Bio Chem 10:26–29]. This new view of basic research aims to bridge the chasm between basic scientific discoveries in life sciences and new drugs that treat the root cause of human disease—recently referred to as the “valley of death” for drug discovery. This perspective article describes new roles that modern organic chemistry will need to play in overcoming this challenge. PMID:21464328

Easy-to-Implement Project Integrates Basic Electronics and Computer Programming

ERIC Educational Resources Information Center

Johnson, Richard; Shackelford, Ray

2008-01-01

The activities described in this article give students excellent experience with both computer programming and basic electronics. During the activities, students will work in small groups, using a BASIC Stamp development board to fabricate digital circuits and PBASIC to write program code that will control the circuits they have built. The…

Introduction to Small Group Discussion.

ERIC Educational Resources Information Center

Millar, Dan Pyle

To bring educational research into focus with tested classroom practice, this booklet provides an introduction to small group discussion. The theory and research section discusses the importance of small group discussion, characteristics of small group discussions, group attraction based on Maslow's hierarchy of basic human needs, group decision…

"Small Steps, Big Rewards": You Can Prevent Type 2 Diabetes

MedlinePlus

... Home Current Issue Past Issues Special Section "Small Steps, Big Rewards": You Can Prevent Type 2 Diabetes ... onset. Those are the basic facts of "Small Steps. Big Rewards: Prevent type 2 Diabetes," created by ...

Project EASE II. Workplace Education Curricula: From Teaching Basic Skills to Training the Trainer.

ERIC Educational Resources Information Center

Northern Illinois Univ., De Kalb.

This curriculum guide was created to guide workplace basic skills instructors in the design of customized curricula for Project Employment Assistance and Skill Enhancement (EASE II), an on-the-job literacy and basic skills improvement project for employees of small companies in the metal working industry in the Chicago area. The guide contains…

13 CFR 120.424 - What are the basic conditions a Lender must meet to securitize?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the basic conditions a Lender must meet to securitize? 120.424 Section 120.424 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Lenders Participating Lender Financings § 120.424 What are the basic conditions a...

The Context of Military Environments: An Agenda for Basic Research on Social and Organizational Factors Relevant to Small Units

DTIC Science & Technology

2014-06-01

Agenda for Basic Research on Social and Organizational Factors Relevant to Small Units NORMS IN MILITARY ENVIRONMENTS 25 group members regardless of...Army personnel. FUTURE RESEARCH ON NORMS With a scientifically informed understanding of social norms, the roles they play in individual and group ...world, and insufficient research has been conducted on similar groups (with respect to size, responsibility, mission, etc.) to be of much utility to

Making Small Schools Work: A Handbook for Teachers in Small Rural Schools.

ERIC Educational Resources Information Center

Sigsworth, Alan; Solstad, Karl Jan

This handbook addresses the provision of an equitable basic education in rural areas, particularly in developing countries, by means of small schools located close to the pupils' homes. It is based on beliefs that small schools can be good schools; the appropriate place for a small school and its teachers is within the community; and small schools…

Small Business Course for Older Americans. Student Handbook.

ERIC Educational Resources Information Center

American Association of Community and Junior Colleges, Washington, DC.

This student handbook was designed for a course which offers people aged 55 and older guidance in starting and operating a small business. Following introductory remarks concerning small businesses, information and assignment sheets related to each of the course's basic units are presented. Course units include the following: (1) Small Business…

Basic Business and Economics: Rationale for a Course in Small Business Management.

ERIC Educational Resources Information Center

Swanson, Robert A.

1979-01-01

Stating that small business represents most of the nation's business but that business courses focus on corporate giants, the author presents arguments for a course in small business management. This course could prepare students for small business opportunities and provide an understanding of the nature of small business management and ownership.…

Basic Research and Progress against Cancer

Cancer.gov

An infographic about the importance of basic research for making progress against cancer. The graphic shows the research milestones that led to the development and approval of crizotinib (Xalkori®) to treat certain non-small cell lung cancers.

Contextualizing the relevance of basic sciences: small-group simulation with debrief for first- and second-year medical students in an integrated curriculum.

PubMed

Ginzburg, Samara B; Brenner, Judith; Cassara, Michael; Kwiatkowski, Thomas; Willey, Joanne M

2017-01-01

There has been a call for increased integration of basic and clinical sciences during preclinical years of undergraduate medical education. Despite the recognition that clinical simulation is an effective pedagogical tool, little has been reported on its use to demonstrate the relevance of basic science principles to the practice of clinical medicine. We hypothesized that simulation with an integrated science and clinical debrief used with early learners would illustrate the importance of basic science principles in clinical diagnosis and management of patients. Small groups of first- and second-year medical students were engaged in a high-fidelity simulation followed by a comprehensive debrief facilitated by a basic scientist and clinician. Surveys including anchored and open-ended questions were distributed at the conclusion of each experience. The majority of the students agreed that simulation followed by an integrated debrief illustrated the clinical relevance of basic sciences (mean ± standard deviation: 93.8% ± 2.9% of first-year medical students; 96.7% ± 3.5% of second-year medical students) and its importance in patient care (92.8% of first-year medical students; 90.4% of second-year medical students). In a thematic analysis of open-ended responses, students felt that these experiences provided opportunities for direct application of scientific knowledge to diagnosis and treatment, improving student knowledge, simulating real-world experience, and developing clinical reasoning, all of which specifically helped them understand the clinical relevance of basic sciences. Small-group simulation followed by a debrief that integrates basic and clinical sciences is an effective means of demonstrating the relationship between scientific fundamentals and patient care for early learners. As more medical schools embrace integrated curricula and seek opportunities for integration, our model is a novel approach that can be utilized.

Cytoskeletal rearrangements in human red blood cells induced by snake venoms: light microscopy of shapes and NMR studies of membrane function.

PubMed

Yau, Tsz Wai; Kuchel, Rhiannon P; Koh, Jennifer M S; Szekely, David; Mirtschin, Peter J; Kuchel, Philip W

2012-01-01

RBCs (red blood cells) circulating through narrow blood capillaries withstand major deformation. The mechanical and chemical stresses commonly exerted on RBCs continue to attract interest for the study of membrane structure and function. Snake venoms are lethal biochemical 'cocktails' that often contain haemotoxins, metalloproteinases, myotoxins, neurotoxins, phosphodiesterases, phospholipases and proteases. We have monitored the effects of 4 snake venoms (Pseudechis guttatus, Oxyuranus scutellatus, Notechis scutatus and Naja kaouthia) on human RBCs using NMR spectroscopy, DIC (differential interference contrast) and confocal light microscopy. RBCs underwent reproducible stomatocytosis, with unusual geographical-like indentations, spherocytosis, followed by rapid lysis. Confocal micrographs using a fluorescent dye linked to phalloidin showed that the change in morphology was associated with the aggregation of actin in the cytoskeleton. (31)P NMR saturation transfer experiments recorded transport of the univalent anion HPA (hypophosphite) on a subsecond time scale, thereby reporting on the function of capnophorin or Band 3 linked to the cytoskeleton; anion-exchange activity was substantially reduced by venom treatment. We propose a molecular-cytological hypothesis for the shape and functional changes that is different from, or supplementary to, the more 'traditional' bilayer-couple hypothesis more often used to account for similar morphological changes invoked by other reagents. © The Author(s) Journal compilation © 2012 Portland Press Limited

Preliminary X-ray crystallographic studies of BthTX-II, a myotoxic Asp49-phospholipase A{sub 2} with low catalytic activity from Bothrops jararacussu venom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corrêa, L. C.; Marchi-Salvador, D. P.; Cintra, A. C. O.

2006-08-01

A myotoxic Asp49-PLA{sub 2} with low catalytic activity from B. jararacussu (BthTX-II) was crystallized in the monoclinic crystal system; a complete X-ray diffraction data set was collected and a molecular-replacement solution was obtained. The oligomeric structure of BthTX-II resembles those of the Asp49-PLA{sub 2} PrTX-III and all bothropic Lys49-PLA{sub 2}s. For the first time, a complete X-ray diffraction data set has been collected from a myotoxic Asp49-phospholipase A{sub 2} (Asp49-PLA{sub 2}) with low catalytic activity (BthTX-II from Bothrops jararacussu venom) and a molecular-replacement solution has been obtained with a dimer in the asymmetric unit. The quaternary structure of BthTX-II resemblesmore » the myotoxin Asp49-PLA{sub 2} PrTX-III (piratoxin III from B. pirajai venom) and all non-catalytic and myotoxic dimeric Lys49-PLA{sub 2}s. In contrast, the oligomeric structure of BthTX-II is different from the highly catalytic and non-myotoxic BthA-I (acidic PLA{sub 2} from B. jararacussu). Thus, comparison between these structures should add insight into the catalytic and myotoxic activities of bothropic PLA{sub 2}s.« less

Statin-associated immune-mediated myopathy: biology and clinical implications.

PubMed

Christopher-Stine, Lisa; Basharat, Pari

2017-04-01

In the last 6 years, our understanding of statin-associated myopathy expanded to include not only a toxic myopathy with limited and reversible side-effects but also an autoimmune variety in which statins likely induce an autoimmune myopathy that is both associated with a specific autoantibody and responsive to immunosuppression and immune modulation. This review widens the reader's understanding of statin myopathy to include an autoimmune process. Statin-associated immune-mediated myopathy provides an example of an environmental trigger (statins) directly implicated in an autoimmune disease associated with a genetic predisposition as well as potential risk factors including concomitant diseases and specific statins. Given a median exposure to statins of 38 months, providers should be aware that anti-3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) myopathy may occur even after several years of statin exposure. It is important for the reader to understand the clinical presentation of statin-associated immune-mediated myopathy and the difference in its clinical presentation to that of statins as direct myotoxins. Prompt recognition of such an entity allows the clinician to immediately stop the offending agent if it has not already been discontinued as well as to recognize that statin rechallenge is not a likely option, and that prompt treatment with immunosuppression and/or immunomodulation is usually of enormous benefit to the patient in restoring muscle strength and physical function. VIDEO ABSTRACT.

Report on Phase I (Interest, Comprehension, & Readability) Prepublication Learner Verification of "Reading Basics Plus," Harper & Row, Publishers, Inc.

ERIC Educational Resources Information Center

Ball, Edward H.

"Reading Basics Plus" consists of an integrated set of texts, workbooks, duplicating masters, word cards, charts, and teacher's guidebooks. By a process of small group trials, students' and teachers' reactions to the proposed content of the "Reading Basics Plus" program for grades four, five, and six were obtained in order to provide editors and…

Learn about Small Wastewater Systems

EPA Pesticide Factsheets

Many small and rural communities, including those in Indian Country and along the U.S.-Mexico border, struggle with aging or inadequate wastewater treatment systems, or do not have access to basic wastewater services.

Management Education for Small and Medium-Sized Enterprises in the European Communities.

ERIC Educational Resources Information Center

Holzer, Rainer

This report summarizes the activities of various bodies providing training impetus for small and medium-sized enterprises (SMEs) in Europe on the three levels of (1) basic management education for potential small and medium-sized business owners and/or managers; (2) programs for small firm start-ups; and (3) activities to improve the management of…

The Small Business Aspect of Bookkeeping/Accounting

ERIC Educational Resources Information Center

Schmidt, Gary D.

1976-01-01

Bookkeeping/accounting teachers must familiarize students with the concepts necessary for success in a small business; students should be aware of the various accounting services available to the small businessman and how to use them, and understand basic accounting terminology and systems and financial statements. Implementation suggestions are…

Starting with the Business Basics.

ERIC Educational Resources Information Center

Hoffman, Carl

1999-01-01

A nonprofit community action agency, BusinesStart, provides business training and small loans to entrepreneurs in 18 rural counties in southwestern Virginia and northeastern Tennessee. The entrepreneurs, many with no previous business experience, cite the agency's basic business training as key to their success. (SV)

Impact of basic angle variations on the parallax zero point for a scanning astrometric satellite

NASA Astrophysics Data System (ADS)

Butkevich, Alexey G.; Klioner, Sergei A.; Lindegren, Lennart; Hobbs, David; van Leeuwen, Floor

2017-07-01

Context. Determination of absolute parallaxes by means of a scanning astrometric satellite such as Hipparcos or Gaia relies on the short-term stability of the so-called basic angle between the two viewing directions. Uncalibrated variations of the basic angle may produce systematic errors in the computed parallaxes. Aims: We examine the coupling between a global parallax shift and specific variations of the basic angle, namely those related to the satellite attitude with respect to the Sun. Methods: The changes in observables produced by small perturbations of the basic angle, attitude, and parallaxes were calculated analytically. We then looked for a combination of perturbations that had no net effect on the observables. Results: In the approximation of infinitely small fields of view, it is shown that certain perturbations of the basic angle are observationally indistinguishable from a global shift of the parallaxes. If these kinds of perturbations exist, they cannot be calibrated from the astrometric observations but will produce a global parallax bias. Numerical simulations of the astrometric solution, using both direct and iterative methods, confirm this theoretical result. For a given amplitude of the basic angle perturbation, the parallax bias is smaller for a larger basic angle and a larger solar aspect angle. In both these respects Gaia has a more favourable geometry than Hipparcos. In the case of Gaia, internal metrology is used to monitor basic angle variations. Additionally, Gaia has the advantage of detecting numerous quasars, which can be used to verify the parallax zero point.

Small Group Activities for Introductory Business Classes.

ERIC Educational Resources Information Center

Mundrake, George

1999-01-01

Describes numerous small-group activities for the following areas of basic business education: consumer credit, marketing, business organization, entrepreneurship, insurance, risk management, economics, personal finance, business careers, global markets, and government regulation. (SK)

Anti-jamming Technology in Small Satellite Communication

NASA Astrophysics Data System (ADS)

Jia, Zixiang

2018-01-01

Small satellite communication has an increasingly important position among the wireless communications due to the advantages of low cost and high technology. However, in view of the case that its relay station stays outside the earth, its uplink may face interference from malicious signal frequently. Here this paper classified enumerates existing interferences, and proposes channel signals as main interference by comparison. Based on a basic digital communication process, then this paper discusses the possible anti - jamming techniques that commonly be realized at all stages in diverse processes, and comes to the conclusion that regarding the spread spectrum technology and antenna anti-jamming technology as fundamental direction of future development. This work provides possible thought for the design of new small satellite communication system with the coexistence of multi - technologies. This basic popular science can be consulted for people interested in small satellite communication.

Exploring Small Animal Care. Teacher's Guide.

ERIC Educational Resources Information Center

Livesey, Dennis W.

This course guide in small animal care is designed to give students seeking employment in veterinary hospitals, kennels, or pet shops an opportunity to (1) develop basic skills in small animal handling, sanitation of housing, and nutrition, (2) acquire skills in dog and cat grooming, including shop operation, (3) develop attitudes which contribute…

10 CFR 431.445 - Determination of small electric motor efficiency.

Code of Federal Regulations, 2011 CFR

2011-01-01

... COMMERCIAL AND INDUSTRIAL EQUIPMENT Small Electric Motors Test Procedures § 431.445 Determination of small... the mechanical and electrical characteristics of that basic model, and (ii) Based on engineering or... Department of Energy records showing the method or methods used; the mathematical model, the engineering or...

Small School Design in Practice. Central Ideas -- Focus on The Catskill Area Project.

ERIC Educational Resources Information Center

Tremlett, Willard L.; And Others

Describing major features of the New York Catskill Area Project in Small School Design (CAPSSD) begun in 1957, this pamphlet addresses: (1) Basic Concepts in Small School Design (flexible scheduling, multiple classes, organizational interdependency, teacher versatility, student planning, technological communications, and interagency cooperation);…

The basic aerodynamics of floatation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davies, M.J.; Wood, D.H.

1983-09-01

The original derivation of the basic theory governing the aerodynamics of both hovercraft and modern floatation ovens, requires the validity of some extremely crude assumptions. However, the basic theory is surprisingly accurate. It is shown that this accuracy occurs because the final expression of the basic theory can be derived by approximating the full Navier-Stokes equations in a manner that clearly shows the limitations of the theory. These limitations are used in discussing the relatively small discrepancies between the theory and experiment, which may not be significant for practical purposes.

A Group Leadership Exercise.

ERIC Educational Resources Information Center

Meyer, John; Stafford, Jeff

A group leadership exercise that incorporates the elements of leadership and other aspects of interaction within small groups can be useful in a basic communication course. The exercise is designed around three basic leadership styles: laissez-faire, democratic, and authoritarian. The exercise is conducted in the following way: (1) the class…

Establishing health benefits of bioactive food components: a basic research scientist's perspective

USDA-ARS?s Scientific Manuscript database

Bioactive food components or functional foods have recently received significant attention because of their widely touted positive effects beyond basic nutrition. However, a question continues to lurk: are these 'super foods' backed by sound science or simply an exaggerated portrayal of very small '...

Small Scale Industries.

ERIC Educational Resources Information Center

Rural Development Detwork Bulletin, 1977

1977-01-01

Innovative programs for the promotion of small-scale enterprise are being conducted by a variety of organizations, including universities, government agencies, international research institutes, and voluntary assistance agencies. Their activities encompass basic extension services, management of cooperatives, community action programs, and…

The Missing Link: Workplace Education in Small Business.

ERIC Educational Resources Information Center

Chisman, Forrest P.

An 18-month, 3-phase study examined formal employer-sponsored basic skills instruction in small- and medium-sized firms. Data were gathered through the following methods: in-depth case studies of 72 small and medium firms in 5 states, a series of linked national surveys of 11,000 randomly selected firms, follow-up telephone surveys of 4,317 of…

Tutorial on architectural acoustics

NASA Astrophysics Data System (ADS)

Shaw, Neil; Talaske, Rick; Bistafa, Sylvio

2002-11-01

This tutorial is intended to provide an overview of current knowledge and practice in architectural acoustics. Topics covered will include basic concepts and history, acoustics of small rooms (small rooms for speech such as classrooms and meeting rooms, music studios, small critical listening spaces such as home theatres) and the acoustics of large rooms (larger assembly halls, auditoria, and performance halls).

Democracy and Leadership in Basic Writing Small Groups.

ERIC Educational Resources Information Center

Kurth, Lita

Commonly accepted ideas, on the one hand, about how small groups in a writing class should work and, on the other hand, psychological research about what makes a small group work well are not consistent. Social psychologist Clovis Shepherd claims that the "popular notion that the democratic ideal is a group in which all members exert an equal…

Minding your Own Small Business - An Introductory Curriculum for Small Business Management. Volume I.

ERIC Educational Resources Information Center

Holt, Nancy; And Others

Ten units on the basic knowledge and skills needed to manage a small business are provided in this curriculum guide designed for use with secondary and postsecondary students. Unit topics include forms of businesses, marketing, location, systems and records, promotion, pricing, human relations, financing a business, and effects of business…

Evaluation of a Numeracy Intervention Program Focusing on Basic Numerical Knowledge and Conceptual Knowledge: A Pilot Study.

ERIC Educational Resources Information Center

Kaufmann, Liane; Handl, Pia; Thony, Brigitte

2003-01-01

In this study, six elementary grade children with developmental dyscalculia were trained individually and in small group settings with a one-semester program stressing basic numerical knowledge and conceptual knowledge. All the children showed considerable and partly significant performance increases on all calculation components. Results suggest…

DEVELOPMENT OF COMMUNITY POWER FROM SUSTAINABLE SMALL HYDRO POWER SYSTEMS – ACAPACITY BUILDING PROJECT IN BANGANG, CAMEROON

EPA Science Inventory

Electric power is one of the basic needs for the development of any community. With electric power lacking in most rural communities in Africa, providing basic amenities that are dependent on power such as clean portable drinking water, powering equipment in health and dent...

An Undergraduate Survey Course on Asynchronous Sequential Logic, Ladder Logic, and Fuzzy Logic

ERIC Educational Resources Information Center

Foster, D. L.

2012-01-01

For a basic foundation in computer engineering, universities traditionally teach synchronous sequential circuit design, using discrete gates or field programmable gate arrays, and a microcomputers course that includes basic I/O processing. These courses, though critical, expose students to only a small subset of tools. At co-op schools like…

More Students Master "Basics" on Writing NAEP

ERIC Educational Resources Information Center

Manzo, Kathleen Kennedy

2008-01-01

At a time when many teenagers are consumed by such activities as text-messaging, blogging, and social networking, more middle and high school students than in the past have mastered the formal "basic" writing skills needed to express ideas or share information, national assessment results released last week show. But just small proportions--33…

Japanese representation in leading general medicine and basic science journals: a comparison of two decades.

PubMed

Fukui, Tsuguya; Takahashi, Osamu; Rahman, Mahbubur

2013-11-01

During 1991-2000, Japan contribution to the top general medicine journals was very small although the contribution to the top basic science journals was sizeable. However, it has not been examined whether the contribution to the top general medicine and basic science journals has changed during the last decade (2001-2010). The objective of this study was to compare Japan representation in high-impact general medicine and basic science journals between the years 1991-2000 and 2001-2010. We used PubMed database to examine the frequency of articles originated from Japan and published in 7 high-impact general medicine and 6 high-impact basic science journals. Several Boolean operators were used to connect name of the journal, year of publication and corresponding authors' affiliation in Japan. Compared to the 1991-2000 decade, Japan contribution to the top general medicine journals did not increase over the 2001-2010 period (0.66% vs. 0.74%, P = 0.255). However, compared to the same period, its contribution to the top basic science journals increased during 2001-2010 (2.51% vs. 3.60%, P < 0.001). Japan representation in basic science journals showed an upward trend over the 1991-2000 period (P < 0.001) but remained flat during 2001-2010 (P = 0.177). In contrast, the trend of Japan representation in general medicine journals remained flat both during 1991-2000 (P = 0.273) and 2001-2010 (P = 0.073). Overall, Japan contribution to the top general medicine journals has remained small and unchanged over the last two decades. However, top basic science journals had higher Japan representation during 2001-2010 compared to 1991-2000.

The Sex Difference in Basic Surgical Skills Learning: A Comparative Study.

PubMed

Lou, Zheng; Yan, Fei-Hu; Zhao, Zhi-Qing; Zhang, Wei; Shui, Xian-Qi; Liu, Jia; Zhuo, Dong-Lan; Li, Li; Yu, En-da

2016-01-01

Very little is known of sex-related differences among medical students in the acquisition of basic surgical skills at an undergraduate level. The aim of this study was to investigate the sex differences in basic surgical skills learning and the possible explanations for sex disparities within basic surgical skills education. A didactic description of 10 surgical skills was performed, including knot tying, basic suture I, basic suture II, sterile technique, preoperative preparation, phlebotomy, debridement, laparotomy, cecectomy, and small bowel resection with hand-sewn anastomosis. The students were rated on a 100-point scale for each basic surgical skill. Later during the same semester all the students took the final theoretical examination. A total of 342 (male = 317 and female = 25) medical students participated in a single skills laboratory as part of their third-year medical student clerkship. The mean scores for each of the 10 surgical skills were higher in female group. The difference in sterile technique, preoperative preparation, cecectomy, and small bowel resection with hand-sewn anastomosis reached the significant level. Compared with male medical students, the mean theory examination score was significantly higher in female medical students. Approximately 76% of the (19 of 25) female students expressed their interest in pursuing a surgical career, whereas only 65.5% (207 of 317) male students wanted to be surgical professionals (p = 0.381). Female medical students completed basic surgical skills training more efficiently and passed the theoretical examination with significantly higher scores than male medical students. In the future, studies should be done in other classes in our institution and perhaps other schools to see if these findings are reliable or valid or just a reflection of this 1 sample. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

A myotoxic Lys49 phospholipase A2-homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina.

PubMed

de Roodt, Adolfo; Fernández, Julián; Solano, Daniela; Lomonte, Bruno

2018-06-15

Bothrops cotiara is a pitviper found in Southeastern Brazil and, scarcely, in the Misiones province of Argentina. In contrast to considerable information available on the venom of the Brazilian snake population, that of Misiones has received little attention. While exploring the chromatographic venom profile of Argentinean B. cotiara, a major protein peak was found which, according to a previous study, is not present in the venom of Brazilian origin. The corresponding protein was isolated by RP-HPLC, and characterized by electrophoresis, mass spectrometry, phospholipase A 2 (PLA 2 ) assay, and myotoxic activities. Representing nearly 15% of B. cotiara venom from Misiones, this protein was identified as a Lys49 PLA 2 homologue. In accordance with the characteristics of this toxin family, the protein induced myotoxicity in mice and was devoid of PLA 2 activity. Since previous work reported that no PLA 2 or PLA 2 -homologues occur in B. cotiara venom of Brazilian origin, the presence of an abundant Lys49 PLA 2 homologue in the venom from Misiones highlights a striking phenotypic variation in toxin expression within two populations of a single snake species inhabiting different geographic areas. The considerable proportion of B. cotiara Lys49 PLA 2 homologue myotoxin in the venom alerts that skeletal muscle necrosis might be a potentially relevant consequence of eventual envenomings by this species in Misiones. Copyright © 2018 Elsevier Ltd. All rights reserved.

Response of mitochondrial function to hypothyroidism in normal and regenerated rat skeletal muscle.

PubMed

Zoll, J; Ventura-Clapier, R; Serrurier, B; Bigard, A X

2001-01-01

Although thyroid hormones induce a well known decrease in muscle oxidative capacity, nothing is known concerning their effects on mitochondrial function and regulation in situ. Similarly, the influence of regeneration process is not completely understood. We investigated the effects of hypothyroidism on mitochondrial function in fast gastrocnemius (GS) and slow soleus (SOL) muscles either intact or having undergone a cycle of degeneration/regeneration (Rg SOL) following a local injection of myotoxin. Thyroid hormone deficiency was induced by thyroidectomy and propylthiouracyl via drinking water. Respiration was measured in muscle fibres permeabilised by saponin in order to assess the oxidative capacity of the muscles and the regulation of mitochondria in situ. Oxidative capacities were 8.9 in SOL, 8.5 in Rg SOL and 5.9 micromol O2/min/g dry weight in GS and decreased by 52, 42 and 39% respectively (P < 0.001) in hypothyroid rats. Moreover, the Km of mitochondrial respiration for the phosphate acceptor ADP exhibited a two-fold decrease in Rg SOL and intact SOL by hypothyroidism (P < 0.01), while mitochondrial creatine kinase activity and sensitivity of mitochondrial respiration to creatine were not altered. The results of this study demonstrate that hypothyroidism markedly altered the sensitivity of mitochondrial respiration to ADP but not to creatine in SOL muscles, suggesting that mitochondrial regulation could be partially controlled by thyroid hormones. On the other hand, mitochondrial function completely recovered following regeneration/degeneration, suggesting that thyroid hormones are not involved in the regeneration process per se.

Purification and biochemical characterization of three myotoxins from Bothrops mattogrossensis snake venom with toxicity against Leishmania and tumor cells.

PubMed

de Moura, Andréa A; Kayano, Anderson M; Oliveira, George A; Setúbal, Sulamita S; Ribeiro, João G; Barros, Neuza B; Nicolete, Roberto; Moura, Laura A; Fuly, Andre L; Nomizo, Auro; da Silva, Saulo L; Fernandes, Carla F C; Zuliani, Juliana P; Stábeli, Rodrigo G; Soares, Andreimar M; Calderon, Leonardo A

2014-01-01

Bothrops mattogrossensis snake is widely distributed throughout eastern South America and is responsible for snakebites in this region. This paper reports the purification and biochemical characterization of three new phospholipases A2 (PLA2s), one of which is presumably an enzymatically active Asp49 and two are very likely enzymatically inactive Lys49 PLA2 homologues. The purification was obtained after two chromatographic steps on ion exchange and reverse phase column. The 2D SDS-PAGE analysis revealed that the proteins have pI values around 10, are each made of a single chain, and have molecular masses near 13 kDa, which was confirmed by MALDI-TOF mass spectrometry. The N-terminal similarity analysis of the sequences showed that the proteins are highly homologous with other Lys49 and Asp49 PLA2s from Bothrops species. The PLA2s isolated were named BmatTX-I (Lys49 PLA2-like), BmatTX-II (Lys49 PLA2-like), and BmatTX-III (Asp49 PLA2). The PLA2s induced cytokine release from mouse neutrophils and showed cytotoxicity towards JURKAT (leukemia T) and SK-BR-3 (breast adenocarcinoma) cell lines and promastigote forms of Leishmania amazonensis. The structural and functional elucidation of snake venoms components may contribute to a better understanding of the mechanism of action of these proteins during envenomation and their potential pharmacological and therapeutic applications.

Alkylation of histidine residues of Bothrops jararacussu venom proteins and isolated phospholipases A2: a biotechnological tool to improve the production of antibodies.

PubMed

Guimarães, C L S; Andrião-Escarso, S H; Moreira-Dill, L S; Carvalho, B M A; Marchi-Salvador, D P; Santos-Filho, N A; Fernandes, C A H; Fontes, M R M; Giglio, J R; Barraviera, B; Zuliani, J P; Fernandes, C F C; Calderón, L A; Stábeli, R G; Albericio, F; da Silva, S L; Soares, A M

2014-01-01

Crude venom of Bothrops jararacussu and isolated phospholipases A2 (PLA2) of this toxin (BthTX-I and BthTX-II) were chemically modified (alkylation) by p-bromophenacyl bromide (BPB) in order to study antibody production capacity in function of the structure-function relationship of these substances (crude venom and PLA2 native and alkylated). BthTX-II showed enzymatic activity, while BthTX-I did not. Alkylation reduced BthTX-II activity by 50% while this process abolished the catalytic and myotoxic activities of BthTX-I, while reducing its edema-inducing activity by about 50%. Antibody production against the native and alkylated forms of BthTX-I and -II and the cross-reactivity of antibodies to native and alkylated toxins did not show any apparent differences and these observations were reinforced by surface plasmon resonance (SPR) data. Histopathological analysis of mouse gastrocnemius muscle sections after injection of PBS, BthTX-I, BthTX-II, or both myotoxins previously incubated with neutralizing antibody showed inhibition of the toxin-induced myotoxicity. These results reveal that the chemical modification of the phospholipases A2 (PLA2) diminished their toxicity but did not alter their antigenicity. This observation indicates that the modified PLA2 may provide a biotechnological tool to attenuate the toxicity of the crude venom, by improving the production of antibodies and decreasing the local toxic effects of this poisonous substance in animals used to produce antivenom.

Heated Discharge Control and Management Alternatives: Small Water Bodies and Rivers.

ERIC Educational Resources Information Center

MacLaren, James F.

Basic concepts of waste heat management on shallow and deep small water bodies and rivers are reviewed and examples are given. This study defines a small water body as a body in which the far field hydrothermal effects of a heated discharge can be detected in a major portion or practically all of the water body. Environmental effects due to…

The Missing Link: Workplace Education in Small Business.

ERIC Educational Resources Information Center

BCEL Newsletter for the Business & Literacy Communities, 1992

1992-01-01

A study sought to determine how and why small businesses invest or do not invest in basic skills instruction for their workers. Data were gathered through a national mail and telephone survey of a random sampling of 11,000 small (50 or fewer employees) and medium-sized (51-400 employees) firms, a targeted mail survey of 4,317 manufacturers, a…

Translational bioinformatics: linking the molecular world to the clinical world.

PubMed

Altman, R B

2012-06-01

Translational bioinformatics represents the union of translational medicine and bioinformatics. Translational medicine moves basic biological discoveries from the research bench into the patient-care setting and uses clinical observations to inform basic biology. It focuses on patient care, including the creation of new diagnostics, prognostics, prevention strategies, and therapies based on biological discoveries. Bioinformatics involves algorithms to represent, store, and analyze basic biological data, including DNA sequence, RNA expression, and protein and small-molecule abundance within cells. Translational bioinformatics spans these two fields; it involves the development of algorithms to analyze basic molecular and cellular data with an explicit goal of affecting clinical care.

Social Planning for Small Cities.

ERIC Educational Resources Information Center

Meyers, James

Derived mainly from publications by the League of California Cities, this guide to social planning for small cities presents the following: (1) social planning definitions; (2) a checklist of social planning concerns (provision for: adequate income and economic opportunity; optimal environmental conditions for basic material needs; optimal health…

Criteria for Using Technology To Teach the Basic Course in Communication.

ERIC Educational Resources Information Center

Eadie, William F.; Andersen, Peter A.; Armas-Matsumoto, Catherine M.; Block, Evan; Martin, Patricia Geist; Goehring, Charles; Good, Jeffrey; Hellweg, Susan A.; Knight, Laura L.; Lubic, Bryan; Spitzberg, Brian H.

This paper describes the beginnings of a project to remake the oral communication general education course--part of the vision for the course is to use technology to help students learn course content. According to the paper, currently the basic course is taught mostly in traditional format (relatively small sections with set assignments), with…

Recruitment Issues and Strategies for Adults Who Are Not Currently Participating in Literacy and Adult Basic Education (ABE) Programs.

ERIC Educational Resources Information Center

Kohring, Aaron

Adult basic education (ABE) and literacy programs have used many different strategies and tools to recruit new students. A small sampling of Tennessee ABE programs shows the more effective recruitment strategies are word-of-mouth referrals; newspaper advertisements and articles; fliers; brochures; posters, radio messages, and public service…

Slushie World: An In-Class Access Database Tutorial

ERIC Educational Resources Information Center

Wynn, Donald E., Jr.; Pratt, Renée M. E.

2015-01-01

The Slushie World case study is designed to teach the basics of Microsoft Access and database management over a series of three 75-minute class sessions. Students are asked to build a basic database to track sales and inventory for a small business. Skills to be learned include table creation, data entry and importing, form and report design,…

Peer-Assisted Learning: Filling the Gaps in Basic Science Education for Preclinical Medical Students

ERIC Educational Resources Information Center

Sammaraiee, Yezen; Mistry, Ravi D.; Lim, Julian; Wittner, Liora; Deepak, Shantal; Lim, Gareth

2016-01-01

In contrast to peer-assisted learning (PAL) in clinical training, there is scant literature on the efficacy of PAL during basic medical sciences teaching for preclinical students. A group of senior medical students aimed to design and deliver clinically oriented small-group tutorials after every module in the preclinical curriculum at a United…

Economic Development for Small Communities and Rural Areas.

ERIC Educational Resources Information Center

Phillips, Phillip D.

This book is designed to provide an introductory understanding of challenges, goals, processes, and procedures for economic developers, particularly economic development volunteers, in rural areas and small towns. Chapter 1 defines economic development and basic terms. Chapter 2 describes major economic, social, and demographic trends that…

Achieving Success in Small Business: A Self-Instruction Program for Small Business Owner-Managers. Developing Ads That Produce Results.

ERIC Educational Resources Information Center

Virginia Polytechnic Inst. and State Univ., Blacksburg. Div. of Vocational-Technical Education.

This self-instructional module on developing ads that produce results is the sixth in a set of twelve modules designed for small business owner-managers. Competencies for this module are (1) identify three guidelines to be considered when you invest money in advertising, (2) identify the five basic elements of a printed advertisement, and (3)…

A Quick Win: Teaching Basic Skills in Context for Better Outcomes an Examination of Success Factors, with a Special Focus on the Potential for the Rapid Building of Self-Efficacy in Emerging Initiatives for "At Risk" Students at California Community Colleges

ERIC Educational Resources Information Center

Hirsh, Deborah Duggin

2011-01-01

A small but growing body of evidence in reports, journal articles and conference papers indicates that if basic skills are embedded within specific career training programs, under-prepared students can acquire life enhancing basic skills at a higher rate than when those skills are taught in the traditional, unconnected way (Baker et al., 2009; Kuh…

Gravity. Physical Science in Action[TM]. Schlessinger Science Library. [Videotape].

ERIC Educational Resources Information Center

2000

All kids are familiar with the basic idea of gravity--it's why things fall to the ground. Gravity uses exciting visuals and clear, colorful graphics to take students beyond the basics to explain that gravity is really a force of attraction between objects. They'll discover that all objects--no matter how large or small--have gravitational force,…

ADA Guide for Small Businesses.

ERIC Educational Resources Information Center

Department of Justice, Washington, DC. Civil Rights Div.

This guide presents an informal overview of some basic Americans with Disabilities Act (ADA) requirements for small businesses that provide goods or services to the public. References to key sections of the regulations or other information are included. The first section describes the ADA briefly. Section two lists the 12 categories of public…

Source Distribution Method for Unsteady One-Dimensional Flows With Small Mass, Momentum, and Heat Addition and Small Area Variation

NASA Technical Reports Server (NTRS)

Mirels, Harold

1959-01-01

A source distribution method is presented for obtaining flow perturbations due to small unsteady area variations, mass, momentum, and heat additions in a basic uniform (or piecewise uniform) one-dimensional flow. First, the perturbations due to an elemental area variation, mass, momentum, and heat addition are found. The general solution is then represented by a spatial and temporal distribution of these elemental (source) solutions. Emphasis is placed on discussing the physical nature of the flow phenomena. The method is illustrated by several examples. These include the determination of perturbations in basic flows consisting of (1) a shock propagating through a nonuniform tube, (2) a constant-velocity piston driving a shock, (3) ideal shock-tube flows, and (4) deflagrations initiated at a closed end. The method is particularly applicable for finding the perturbations due to relatively thin wall boundary layers.

Owning and Operating a Small Business. A Guide for Industrial Cooperative Training Programs. Learning Activity Package No. 14.

ERIC Educational Resources Information Center

Braden, Robert P.; Remzi, Kerim

This learning activity package (LAP) on starting a small business is designed for student self-study. It will help students learn about their aptitudes and abilities as well as about the basics of running a small business. Following a list of learning objectives, the LAP contains a pretest (answer key provided at the end of the LAP). Ten learning…

A Pilot Study of Naltrexone and BASICS for Heavy Drinking Young Adults

PubMed Central

Leeman, Robert F.; Palmer, Rebekka S.; Corbin, William R.; Romano, Denise M.; Meandzija, Boris; O’Malley, Stephanie S.

2008-01-01

Heavy drinking young adults often have limited motivation to change their drinking behavior. Adding pharmacotherapy to brief counseling is a novel approach to treating this population. A small open-label pilot study was conducted to assess the feasibility of offering eight weeks of daily and targeted (i.e., taken as needed in anticipation of drinking) naltrexone with BASICS (brief motivational) counseling to heavy drinking young adults; to assess the tolerability of the medication in this population and to obtain preliminary efficacy data. The sample (N = 14) showed strong adherence to study appointments and medication taking, supporting the feasibility of this approach. Overall, the medication was well-tolerated. Significant reductions from baseline were observed in drinks per drinking day and in percent heavy drinking days and these gains were maintained one month after treatment ended. A significant decrease in alcohol-related consequences was also observed. Findings from this small pilot study suggest that naltrexone in combination with BASICS represents a promising strategy to reduce heavy drinking among young adults. PMID:18502591

Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa*

PubMed Central

Eren, Elif; Parkin, Jamie; Adelanwa, Ayodele; Cheneke, Belete; Movileanu, Liviu; Khalid, Syma; van den Berg, Bert

2013-01-01

Because small molecules enter Gram-negative bacteria via outer membrane (OM) channels, understanding OM transport is essential for the rational design of improved and new antibiotics. In the human pathogen Pseudomonas aeruginosa, most small molecules are taken up by outer membrane carboxylate channel (Occ) proteins, which can be divided into two distinct subfamilies, OccD and OccK. Here we characterize substrate transport mediated by Occ proteins belonging to both subfamilies. Based on the determination of the OccK2-glucuronate co-crystal structure, we identify the channel residues that are essential for substrate transport. We further show that the pore regions of the channels are rigid in the OccK subfamily and highly dynamic in the OccD subfamily. We also demonstrate that the substrate carboxylate group interacts with central residues of the basic ladder, a row of arginine and lysine residues that leads to and away from the binding site at the channel constriction. Moreover, the importance of the basic ladder residues corresponds to their degree of conservation. Finally, we apply the generated insights by converting the archetype of the entire family, OccD1, from a basic amino acid-specific channel into a channel with a preference for negatively charged amino acids. PMID:23467408

DOE Office of Scientific and Technical Information (OSTI.GOV)

Braiman, Yehuda; Neschke, Brendan; Nair, Niketh S.

Here, we study memory states of a circuit consisting of a small inductively coupled Josephson junction array and introduce basic (write, read, and reset) memory operations logics of the circuit. The presented memory operation paradigm is fundamentally different from conventional single quantum flux operation logics. We calculate stability diagrams of the zero-voltage states and outline memory states of the circuit. We also calculate access times and access energies for basic memory operations.

Workplace ESL Literacy in Diverse Small Business Contexts: Final Evaluation Report on Project EXCEL.

ERIC Educational Resources Information Center

Hemphill, David F.

Project EXCEL, a workplace literacy project involving four small business enterprises in San Francisco, is evaluated. The project focused on literacy and basic skills training for limited-English-proficient (LEP) workers. The businesses included the following: a communications and mass mailing firm; a dessert wholesale company; a Mexican…

Small Schools Curriculum: Physical Education, 7-12.

ERIC Educational Resources Information Center

Hartl, David, Ed.; Hartl, Doris, Ed.

Two self-contained sections within the document (one for grades 7-8, the other for grades 9-12) present the Washington Small Schools secondary physical education curriculum. Activities are written to supplement or extend a basic text by presenting a game, simulation or activity to carry out a learning objective. Identical introductory materials…

Effects of Sugar (Sucrose) on Children's Behavior.

ERIC Educational Resources Information Center

Rosen, Lee A.; And Others

1988-01-01

Examined effects of sugar on behavior of 45 preschool and elementary school children. Provided all children with basic breakfast that included drink containing either 50 g of sucrose, a comparably sweet placebo, or very little sucrose. Found some small behavior changes in high-sucrose group. All effects were small in magnitude and not considered…

Developing a Strong Bond between Education and Local Businesses in Rural Areas.

ERIC Educational Resources Information Center

Phillips, William A.

This paper describes a Small Business Development Center (SBDC) located at the Central Arizona College. Schools are responsible for assisting economic development in the small business and business community since industry spends $22 billion per year in retraining high school graduates and dropouts in basic education. In Pinal County, Arizona,…

Teaching Spatial Awareness In Small-Sided Games

ERIC Educational Resources Information Center

Phillips, David; Hannon, James C.; Molina, Sergio

2015-01-01

This article supports the use of strategy and tactics at games stage three (how to teach basic offensive and defensive strategy using small-sided games) as a best practices in physical education. Potential learning through game stages three and four (full-sided games) is only possible when teachers have advanced content knowledge to teach the…

Basics of Sterile Compounding: Particulate Matter.

PubMed

Akers, Michael J

2017-01-01

This article focuses on the requirements for particulate matter in sterile products. Topics include particles and quality, particulate matter standards (large- and small-volume injectables), development of the small-volume injectable test, electronic (light obscuration) and microscope testing, and special requirements for particulate matter in biopharmaceutical preparations. Copyright© by International Journal of Pharmaceutical Compounding, Inc.

Small Business Management; Business Education: 7739.11.

ERIC Educational Resources Information Center

McCool, Felix J.

This curriculum guide gives a brief review of the relation of business to the community and an introduction to problems in organizing a small business. These problems include basic long-range decisions: type of financing, need for the business, and method of financing. The document also focuses on the more immediate problems of location, housing,…

Methods and Strategies: Much Ado about Nothing

ERIC Educational Resources Information Center

Smith, P. Sean; Plumley, Courtney L.; Hayes, Meredith L.

2017-01-01

This column provides ideas and techniques to enhance your science teaching. This month's issue discusses how children think about the small-particle model of matter. What Richard Feynman referred to as the "atomic hypothesis" is perhaps more familiar to us as the small-particle model of matter. In its most basic form, the model states…

Communication: A Plan for Small School Districts.

ERIC Educational Resources Information Center

Council of Communicators, Austin, TX.

Since communication is the working link between the school district and the community it serves, public school administrators serving small towns or rural areas are developing a planned program of two-way communication based on a clear policy statement adopted by the board of trustees which basically upholds the public's right to know. In order to…

Small area estimation for estimating the number of infant mortality in West Java, Indonesia

NASA Astrophysics Data System (ADS)

Anggreyani, Arie; Indahwati, Kurnia, Anang

2016-02-01

Demographic and Health Survey Indonesia (DHSI) is a national designed survey to provide information regarding birth rate, mortality rate, family planning and health. DHSI was conducted by BPS in cooperation with National Population and Family Planning Institution (BKKBN), Indonesia Ministry of Health (KEMENKES) and USAID. Based on the publication of DHSI 2012, the infant mortality rate for a period of five years before survey conducted is 32 for 1000 birth lives. In this paper, Small Area Estimation (SAE) is used to estimate the number of infant mortality in districts of West Java. SAE is a special model of Generalized Linear Mixed Models (GLMM). In this case, the incidence of infant mortality is a Poisson distribution which has equdispersion assumption. The methods to handle overdispersion are binomial negative and quasi-likelihood model. Based on the results of analysis, quasi-likelihood model is the best model to overcome overdispersion problem. The basic model of the small area estimation used basic area level model. Mean square error (MSE) which based on resampling method is used to measure the accuracy of small area estimates.

A preliminary assessment of small steam Rankine and Brayton point-focusing solar modules

NASA Technical Reports Server (NTRS)

Roschke, E. J.; Wen, L.; Steele, H.; Elgabalawi, N.; Wang, J.

1979-01-01

A preliminary assessment of three conceptual point-focusing distributed solar modules is presented. The basic power conversion units consist of small Brayton or Rankine engines individually coupled to two-axis, tracking, point-focusing solar collectors. An array of such modules can be linked together, via electric transport, to form a small power station. Each module also can be utilized on a stand-alone basis, as an individual power source.

Clinical studies of the Research Committee on Intractable Vasculitides, the Ministry of Health, Labour and Welfare of Japan.

PubMed

Makino, Hirofumi; Sada, Ken-Ei

2013-10-01

In Japan, the Research Committee on Intractable Vasculitides, supported by the Ministry of Health, Labour and Welfare, has been promoting basic and clinical research on vasculitis since 1972. The present Research Committee on Intractable Vasculitides comprises 4 subcommittees under the direction of a Principal Investigator: Basic and Pathological Research Subcommittee, Clinical Research Subcommittee of Small and Medium-sized Vessel Vasculitis, Clinical Research Subcommittee of Large-sized Vessel Vasculitis, and International Cooperation Research Subcommittee. Since 2008, 9 nationwide clinical studies for vasculitis have been conducted and 8 clinical and basic studies are in progress.

Spine-bellied sea snake (Hydrophis curtus) venom shows greater skeletal myotoxicity compared with cardiac myotoxicity.

PubMed

Neale, Vanessa; Smout, Michael J; Seymour, Jamie E

2018-03-01

For the first time the impedance-based xCELLigence real-time cell analysis system was used to measure the myotoxicity of sea snake venom. With a focus on the spine-bellied sea snake (Hydrophis curtus), the venom of four sea snake species and three terrestrial snake species were compared for myotoxicity against a human skeletal muscle cell line (HSkMC). Hydrophis curtus venom was also tested on a human cardiac muscle cell line (HCM). Surprisingly, all four sea snake venoms tested on HSkMC produced an initial 100-280% rise in xCELLigence cell index that peaked within the first two hours before falling. The cell index rise of H. curtus venom was correlated with the WST-1 cell proliferation assay, which demonstrated an increase in mitochondrial metabolism. The myotoxicity of H. curtus was 4.7-8.2 fold less potent than the other sea snakes tested, the Australian beaked sea snake (Hydrophis zweifeli), the elegant sea snake (Hydrophis elegans) and the olive sea snake (Aipysurus laevis). If our cell-based results translate to H. curtus envenomations, this implies that H. curtus would be less myotoxic than the other three. Yet the myotoxicity of H. curtus venom to cardiac muscle cells was nine times weaker than for skeletal muscle cells, providing evidence that the venom has a selective effect on skeletal muscle cells. This evidence, combined with the slow-acting nature of the venom, supports a digestive role for sea snake myotoxins. Copyright © 2018 Elsevier Ltd. All rights reserved.

Comparison of the neurotoxic and myotoxic effects of two Moroccan scorpion venoms and their neutralization by experimental polyclonal antivenom.

PubMed

Oukkache, Naoual; Ahmad Rusmili, Muhamad Rusdi; Othman, Iekhsan; Ghalim, Noreddine; Chgoury, Fatima; Boussadda, Lofti; Elmdaghri, Naima; Sabatier, Jean-Marc

2015-03-01

Scorpion venoms contain complex mixtures of molecules, including peptides. These peptides specifically bind to various targets, in particular ion channels. Toxins modulating Na(+), K(+), Ca(2+) and Cl(-) currents were described from venoms. The Androctonus and Buthus geni of scorpions are widely distributed in Morocco. Their stings can cause pain, inflammation, necrosis, muscle paralysis and death. The myotoxicity is predominantly associated with neurotoxic effects and is a cause of mortality and morbidity. In this study, pharmacological effects of venoms were investigated in vitro on neuromuscular transmission. Effects of Androctonus mauretanicus (Am) and Buthus occitanus (Bo) venoms were investigated using the chick biventer cervicis nerve-muscle preparations. The protective activity of antivenom was also investigated. The antivenom was made from serum of horse that was hyperimmunized with Bo and Androctonus australis hector (Aah) venoms and one venom from Middle East species (Lq). The protective activity of the antivenom was assessed on the neuromuscular system by using stimulated chick nerve-muscle. The results were compared with lethal activity neutralization in mice. Am and Bo venoms contain myotoxins and postsynaptic neurotoxins. In agreement with lethal potencies of these venoms in mice, Am venom displays greater neurotoxicity and myotoxicity. The antivenom prevented lethality caused by Am, Bo and Aah venoms. The antivenom did not prevent toxic effects caused by Am venom whereas it neutralized Bo venom. Am and Bo venoms contain distinct toxins that are responsible for myotoxicity and neurotoxicity. It would be appropriate to add Am venom to produce more efficient antivenom. Copyright © 2015 Elsevier Inc. All rights reserved.

Don't be Half-Educated About Haff Disease in Louisiana.

PubMed

Diaz, James

2015-01-01

Cases of Haff disease, a syndrome of severe myalgia and rhabdomyolysis, have been reported after eating cooked fish in Europe and the US. A retrospective review of US cases was conducted to identify seafood vectors, describe presenting manifestations, and compare the Haff disease toxidrome with other seafood-borne toxidromes. Internet search engines were queried to identify all US reports of Haff disease. The case definition of Haff disease required cooked seafood ingestion history within 24 hours and markedly elevated serum creatine kinase (CK) with CK-muscle/brain (MB) fraction < 5 percent. Twenty-six cases of Haff disease were reported in the US over 30 years, 1984-2014, with spring-summer occurrences. The mean age of cases was 54.8 years without gender difference. Most cases (58 percent) followed consumption of cooked buffalo fish, Ictiobus cyprinellus, (n = 15); other cases followed consumption of boiled crayfish in Louisiana (n = 9) and baked salmon in North Carolina (n = 2). California and Louisiana accounted for most cases (n = 18, p = 0.012). Following mean incubation periods of eight hours; the most common presenting manifestations included vomiting, myalgia, muscle rigidity, chest pain mimicking myocardial infarction, diaphoresis, dyspnea, and brown urine indicating myoglobinuria. Most patients recovered within 2-5 days. Haff disease may follow the consumption of freshwater buffalo fish, freshwater crayfish, and saltwater Atlantic salmon. The bioconcentration of a new, unidentified heat-stable, freshwater and/or brackish/saltwater algal myotoxin in seafood, similar to palytoxin, is suspected of causing Haff disease. Experimental animals fed toxic buffalo fish developed rhabdomyolysis with myoglobinuria.

Positron Emission Tomography: Principles, Technology, and Recent Developments

NASA Astrophysics Data System (ADS)

Ziegler, Sibylle I.

2005-04-01

Positron emission tomography (PET) is a nuclear medical imaging technique for quantitative measurement of physiologic parameters in vivo (an overview of principles and applications can be found in [P.E. Valk, et al., eds. Positron Emission Tomography. Basic Science and Clinical Practice. 2003, Springer: Heidelberg]), based on the detection of small amounts of posi-tron-emitter-labelled biologic molecules. Various radiotracers are available for neuro-logical, cardiological, and oncological applications in the clinic and in research proto-cols. This overview describes the basic principles, technology, and recent develop-ments in PET, followed by a section on the development of a tomograph with ava-lanche photodiodes dedicated for small animal imaging as an example of efforts in the domain of high resolution tomographs.

Global search and rescue - A new concept. [orbital digital radar system with passive reflectors

NASA Technical Reports Server (NTRS)

Sivertson, W. E., Jr.

1976-01-01

A new terrestrial search and rescue concept is defined embodying the use of simple passive radiofreqeuncy reflectors in conjunction with a low earth-orbiting, all-weather, synthetic aperture radar to detect, identify, and position locate earth-bound users in distress. Users include ships, aircraft, small boats, explorers, hikers, etc. Airborne radar tests were conducted to evaluate the basic concept. Both X-band and L-band, dual polarization radars were operated simultaneously. Simple, relatively small, corner-reflector targets were successfully imaged and digital data processing approaches were investigated. Study of the basic concept and evaluation of results obtained from aircraft flight tests indicate an all-weather, day or night, global search and rescue system is feasible.

Two-Dimensional Photonic Crystals for Sensitive Microscale Chemical and Biochemical Sensing

PubMed Central

Miller, Benjamin L.

2015-01-01

Photonic crystals – optical devices able to respond to changes in the refractive index of a small volume of space – are an emerging class of label-free chemical-and bio-sensors. This review focuses on one class of photonic crystal, in which light is confined to a patterned planar material layer of sub-wavelength thickness. These devices are small (on the order of tens to 100s of microns square), suitable for incorporation into lab-on-a-chip systems, and in theory can provide exceptional sensitivity. We introduce the defining characteristics and basic operation of two-dimensional photonic crystal sensors, describe variations of their basic design geometry, and summarize reported detection results from chemical and biological sensing experiments. PMID:25563402

Changes in conformational dynamics of basic side chains upon protein–DNA association

PubMed Central

Esadze, Alexandre; Chen, Chuanying; Zandarashvili, Levani; Roy, Sourav; Pettitt, B. Montgometry; Iwahara, Junji

2016-01-01

Basic side chains play major roles in recognition of nucleic acids by proteins. However, dynamic properties of these positively charged side chains are not well understood. In this work, we studied changes in conformational dynamics of basic side chains upon protein–DNA association for the zinc-finger protein Egr-1. By nuclear magnetic resonance (NMR) spectroscopy, we characterized the dynamics of all side-chain cationic groups in the free protein and in the complex with target DNA. Our NMR order parameters indicate that the arginine guanidino groups interacting with DNA bases are strongly immobilized, forming rigid interfaces. Despite the strong short-range electrostatic interactions, the majority of the basic side chains interacting with the DNA phosphates exhibited high mobility, forming dynamic interfaces. In particular, the lysine side-chain amino groups exhibited only small changes in the order parameters upon DNA-binding. We found a similar trend in the molecular dynamics (MD) simulations for the free Egr-1 and the Egr-1–DNA complex. Using the MD trajectories, we also analyzed side-chain conformational entropy. The interfacial arginine side chains exhibited substantial entropic loss upon binding to DNA, whereas the interfacial lysine side chains showed relatively small changes in conformational entropy. These data illustrate different dynamic characteristics of the interfacial arginine and lysine side chains. PMID:27288446

Export Now: A Practical Guide for U.S. Minority and Small Business Exporters.

ERIC Educational Resources Information Center

American Association of Community and Junior Colleges, Washington, DC.

This guidebook was designed to orient minority entrepreneurs to the basics of international trade. Market research and strategy are examined, as well as finance, contract negotiations, trade logistics, and business communications. Part I acknowledges that small firms often lack the resources to take even the first step in developing the knowledge,…

The Carter Administration: Small Community and Rural Development Policy.

ERIC Educational Resources Information Center

Carter, Jimmy

The Carter Administration is adopting a Small Community and Rural Development Policy because: (1) rural America's human and natural resources are a mainstay of the nation's economy and way of life; (2) many rural areas are in the midst of significant economic and demographic change; (3) rural people and communities have greater unmet basic human…

Develop the Worker: Develop the Business. A Guide for Smaller Businesses.

ERIC Educational Resources Information Center

McGivney, Veronica

This document, which was developed on the basis of recent research and testimony of small business owners, managers and employees, and training providers, is a basic practical manual for those owners and managers of British small and medium-sized enterprises (SMEs) who want to initiate or improve staff training and development activities. The…

Small Business Location and Layout.

ERIC Educational Resources Information Center

Small Business Administration, Washington, DC.

As an approach to teaching small-business location and layout, this publication contains material for teaching one session of a basic course. The sections of the publication are as follows: (1) The Lesson Plan--an outline of the material covered, which may be used as a teaching guide, presented in two columns: an outline of the presentation, and a…

Gender differences in leadership amongst first-year medical students in the small-group setting.

PubMed

Wayne, Nancy L; Vermillion, Michelle; Uijtdehaage, Sebastian

2010-08-01

To investigate the extent of gender bias in the volunteerism of small-group leaders amongst first-year medical students, and whether bias could be eliminated with special instructions to the students. The gender of leaders in small-group sessions in a real academic setting was monitored under two conditions: control conditions, in which basic instructions were provided to participants, and intervention conditions, in which the same basic instructions were provided plus a brief "pep talk" on the importance of experiencing a leadership role in a safe environment. During the small-group sessions, an observer noted the gender and names of group leaders for later analysis. After a class debriefing, a subset of leaders and nonleaders from both the control and intervention groups were invited to be interviewed about their perceptions of the small-group experience. Interviews were tape recorded and transcribed for analysis. In 2007-2008 and 2008-2009, disproportionately fewer women than men volunteered to become small-group leaders under control conditions. This gender bias was eliminated under intervention conditions. The interviews illustrated how a subtle change in instructions helped some female students take on a leadership role. Gender bias in leadership in the small-group setting amongst medical students-even when women make up half of the class-may persist without targeted intervention. The authors suggest that frequent and consistent intervention during medical school could be an important factor in encouraging women to identify themselves as leaders, promoting confidence to consider leadership roles in medicine.

Joint Terminal Attack Controller: Separating Fact From Fiction

DTIC Science & Technology

2003-04-01

qualified:” “Certified: an individual who has attended the appropriate service level school and has been trained to the standards of a JTAC...numbers illustrates the challenge of keeping a small (pre-JTAC) controller force at the basic proficiency level . DoD has approximately 1,250...with live aircraft are needed to keep the pre-JTAC number of controllers at a basic level . The JTAC program will allow an unchecked number of

Electronic Data Interchange in U.S. Navy Contracting Activities

DTIC Science & Technology

1992-12-01

the basic research question, the following subsidiary questions were asked: 1. How is EDI being used in the private sector and within the Department of...eliminated by using EDI transactions. According to a DoD small business EDI Guide , (DLA Partnership, 1991, p.15) in financial management applications, a...and to place orders against basic ordering agreements (BOA). The ASO is currently transmitting the ASC X12 850 [Purchase Order] to approximately 25

Differences in citation frequency of clinical and basic science papers in cardiovascular research.

PubMed

Opthof, Tobias

2011-06-01

In this article, a critical analysis is performed on differences in citation frequency of basic and clinical cardiovascular papers. It appears that the latter papers are cited at about 40% higher frequency. The differences between the largest number of citations of the most cited papers are even larger. It is also demonstrated that the groups of clinical and basic cardiovascular papers are also heterogeneous concerning citation frequency. It is concluded that none of the existing citation indicators appreciates these differences. At this moment these indicators should not be used for quality assessment of individual scientists and scientific niches with small numbers of scientists.

The development of methods for predicting and measuring distribution patterns of aerial sprays

NASA Technical Reports Server (NTRS)

Ormsbee, A. I.; Bragg, M. B.; Maughmer, M. D.

1979-01-01

The capability of conducting scale model experiments which involve the ejection of small particles into the wake of an aircraft close to the ground is developed. A set of relationships used to scale small-sized dispersion studies to full-size results are experimentally verified and, with some qualifications, basic deposition patterns are presented. In the process of validating these scaling laws, the basic experimental techniques used in conducting such studies, both with and without an operational propeller, were developed. The procedures that evolved are outlined. The envelope of test conditions that can be accommodated in the Langley Vortex Research Facility, which were developed theoretically, are verified using a series of vortex trajectory experiments that help to define the limitations due to wall interference effects for models of different sizes.

Small Upper Stage Basic Program Final Report

DTIC Science & Technology

1991-08-27

design of the SUS. During storage, the SUS shall3 be required to withstand environments as specified in 3.2.5.1. Environmental protection shall be...accomplish this goal, a launch vehicle survey was conducted to establish the current LV capability and environments with respect to small satellites...4 Launch Vehicle Shock Environment ...................................................................... 2-4 2-5 Launch Vehicle Sound Pressure

Light, temperature, and soil moisture responses to elevation, evergreen understory, and small canopy gaps in the southern Appalachians

Treesearch

Barton D. Clinton

2003-01-01

Small canopy openings often alter understory microclimate, leading to changes in forest structure and composition. It is generally accepted that physical changes in the understory (i.e., microclimatic) due to canopy removal drive changes in basic forest processes, particularly seedling recruitment which is intrinsically linked to soil moisture availability, light and,...

A Model of Small-Group Problem-Based Learning in Pharmacy Education: Teaching in the Clinical Environment

ERIC Educational Resources Information Center

Khumsikiew, Jeerisuda; Donsamak, Sisira; Saeteaw, Manit

2015-01-01

Problem-based Learning (PBL) is an alternate method of instruction that incorporates basic elements of cognitive learning theory. Colleges of pharmacy use PBL to aid anticipated learning outcomes and practice competencies for pharmacy student. The purpose of this study were to implement and evaluate a model of small group PBL for 5th year pharmacy…

The development of internet based ship design support system for small and medium sized shipyards

NASA Astrophysics Data System (ADS)

Shin, Sung-Chul; Lee, Soon-Sup; Kang, Dong-Hoon; Lee, Kyung-Ho

2012-03-01

In this paper, a prototype of ship basic planning system is implemented for the small and medium sized shipyards based on the internet technology and concurrent engineering concept. The system is designed from the user requirements. Consequently, standardized development environment and tools are selected. These tools are used for the system development to define and evaluate core application technologies. The system will contribute to increasing competitiveness of small and medium sized shipyards in the 21st century industrial en-vironment.

Supporting Remote Sensing Research with Small Unmanned Aerial Systems

NASA Astrophysics Data System (ADS)

Anderson, R. C.; Shanks, P. C.; Kritis, L. A.; Trani, M. G.

2014-11-01

We describe several remote sensing research projects supported with small Unmanned Aerial Systems (sUAS) operated by the NGA Basic and Applied Research Office. These sUAS collections provide data supporting Small Business Innovative Research (SBIR), NGA University Research Initiative (NURI), and Cooperative Research And Development Agreements (CRADA) efforts in addition to inhouse research. Some preliminary results related to 3D electro-optical point clouds are presented, and some research goals discussed. Additional details related to the autonomous operational mode of both our multi-rotor and fixed wing small Unmanned Aerial System (sUAS) platforms are presented.

Development of an external ceramic insulation for the space shuttle orbiter. Part 2: Optimization

NASA Technical Reports Server (NTRS)

Tanzilli, R. A. (Editor)

1973-01-01

The basic insulation improvement study concentrated upon evaluating variables which could result in significant near-term gains in mechanical behavior and insulation effectiveness of the baseline system. The approaches undertaken included: evaluation of small diameter fibers, optimization of binder: slurry characteristics, evaluation of techniques for controlling fiber orientation, optimization of firing cycle, and the evaluation of methods for improving insulation efficiency. A detailed discussion of these basic insulation improvement studies is presented.

Changes in conformational dynamics of basic side chains upon protein-DNA association.

PubMed

Esadze, Alexandre; Chen, Chuanying; Zandarashvili, Levani; Roy, Sourav; Pettitt, B Montgometry; Iwahara, Junji

2016-08-19

Basic side chains play major roles in recognition of nucleic acids by proteins. However, dynamic properties of these positively charged side chains are not well understood. In this work, we studied changes in conformational dynamics of basic side chains upon protein-DNA association for the zinc-finger protein Egr-1. By nuclear magnetic resonance (NMR) spectroscopy, we characterized the dynamics of all side-chain cationic groups in the free protein and in the complex with target DNA. Our NMR order parameters indicate that the arginine guanidino groups interacting with DNA bases are strongly immobilized, forming rigid interfaces. Despite the strong short-range electrostatic interactions, the majority of the basic side chains interacting with the DNA phosphates exhibited high mobility, forming dynamic interfaces. In particular, the lysine side-chain amino groups exhibited only small changes in the order parameters upon DNA-binding. We found a similar trend in the molecular dynamics (MD) simulations for the free Egr-1 and the Egr-1-DNA complex. Using the MD trajectories, we also analyzed side-chain conformational entropy. The interfacial arginine side chains exhibited substantial entropic loss upon binding to DNA, whereas the interfacial lysine side chains showed relatively small changes in conformational entropy. These data illustrate different dynamic characteristics of the interfacial arginine and lysine side chains. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Being sucessfully disruptive.

PubMed

Hogan, J

2005-06-01

Small companies can more easily create "disruptive" innovation than large companies. This article discusses why and how they can introduce some basic processes to make sure they do not become victims of their own success.

Clinical Correlations as a Tool in Basic Science Medical Education

PubMed Central

Klement, Brenda J.; Paulsen, Douglas F.; Wineski, Lawrence E.

2016-01-01

Clinical correlations are tools to assist students in associating basic science concepts with a medical application or disease. There are many forms of clinical correlations and many ways to use them in the classroom. Five types of clinical correlations that may be embedded within basic science courses have been identified and described. (1) Correlated examples consist of superficial clinical information or stories accompanying basic science concepts to make the information more interesting and relevant. (2) Interactive learning and demonstrations provide hands-on experiences or the demonstration of a clinical topic. (3) Specialized workshops have an application-based focus, are more specialized than typical laboratory sessions, and range in complexity from basic to advanced. (4) Small-group activities require groups of students, guided by faculty, to solve simple problems that relate basic science information to clinical topics. (5) Course-centered problem solving is a more advanced correlation activity than the others and focuses on recognition and treatment of clinical problems to promote clinical reasoning skills. Diverse teaching activities are used in basic science medical education, and those that include clinical relevance promote interest, communication, and collaboration, enhance knowledge retention, and help develop clinical reasoning skills. PMID:29349328

Integrated Medical Curriculum: Advantages and Disadvantages

PubMed Central

Quintero, Gustavo A.; Vergel, John; Arredondo, Martha; Ariza, María-Cristina; Gómez, Paula; Pinzon-Barrios, Ana-Maria

2016-01-01

Most curricula for medical education have been integrated horizontally and vertically–-vertically between basic and clinical sciences. The Flexnerian curriculum has disappeared to permit integration between basic sciences and clinical sciences, which are taught throughout the curriculum. We have proposed a different form of integration where the horizontal axis represents the defined learning outcomes and the vertical axis represents the teaching of the sciences throughout the courses. We believe that a mere integration of basic and clinical sciences is not enough because it is necessary to emphasize the importance of humanism as well as health population sciences in medicine. It is necessary to integrate basic and clinical sciences, humanism, and health population in the vertical axis, not only in the early years but also throughout the curriculum, presupposing the use of active teaching methods based on problems or cases in small groups. PMID:29349303

Mid-level perceptual features distinguish objects of different real-world sizes.

PubMed

Long, Bria; Konkle, Talia; Cohen, Michael A; Alvarez, George A

2016-01-01

Understanding how perceptual and conceptual representations are connected is a fundamental goal of cognitive science. Here, we focus on a broad conceptual distinction that constrains how we interact with objects--real-world size. Although there appear to be clear perceptual correlates for basic-level categories (apples look like other apples, oranges look like other oranges), the perceptual correlates of broader categorical distinctions are largely unexplored, i.e., do small objects look like other small objects? Because there are many kinds of small objects (e.g., cups, keys), there may be no reliable perceptual features that distinguish them from big objects (e.g., cars, tables). Contrary to this intuition, we demonstrated that big and small objects have reliable perceptual differences that can be extracted by early stages of visual processing. In a series of visual search studies, participants found target objects faster when the distractor objects differed in real-world size. These results held when we broadly sampled big and small objects, when we controlled for low-level features and image statistics, and when we reduced objects to texforms--unrecognizable textures that loosely preserve an object's form. However, this effect was absent when we used more basic textures. These results demonstrate that big and small objects have reliably different mid-level perceptual features, and suggest that early perceptual information about broad-category membership may influence downstream object perception, recognition, and categorization processes. (c) 2015 APA, all rights reserved).

The Role of the Small Private College in Creating a Moral, Spiritual Climate in American Society. CASC Newsletter Supplements, 1976-77.

ERIC Educational Resources Information Center

Hatfield, Mark

The capacity of American institutions to preserve and convey basic values to new generations has substantially diminished, suggests this former U.S. Senator from Oregon. His opinion is that the small private college can help create a moral and spiritual climate in society. The range of topics discussed includes: college preservation of values;…

The Education Challenges Facing Small Nation States in the Increasingly Competitive Global Economy of the Twenty-First Century

ERIC Educational Resources Information Center

Bacchus, Mohammed Kazim

2008-01-01

Publication of this piece is intended as a tribute to the late Professor M. Kazim Bacchus who passed away in March 2007. The paper provides a general discussion concerning the social and educational challenges faced by small nation states in an age characterised by globalisation. The analysis first identifies some of the basic features of small…

Chinese Biogas Digester. A Potential Model for Small-Scale, Rural Applications. (A Manual for Construction and Operation). Reprint No. R-51.

ERIC Educational Resources Information Center

Nakagawa, Charles H.; Honquilada, Q. L.

This book provides the basic knowledge and guides for the construction and operation of a small-scale, family-size biogas unit. The first chapter discusses the benefits of biogas production and the Chinese biogas model. The second chapter shows the components, design formulas, and sizing units of the biogas model. Chapter 3 describes actual…

Diazo compounds for the bioreversible esterification of proteins† †Electronic supplementary information (ESI) available: Experimental procedures, analytical data, and spectral data for novel compounds. See DOI: 10.1039/c4sc01768d Click here for additional data file.

PubMed Central

McGrath, Nicholas A.; Andersen, Kristen A.; Davis, Amy K. F.; Lomax, Jo E.

2015-01-01

A diazo compound is shown to convert carboxylic acids to esters efficiently in an aqueous environment. The basicity of the diazo compound is critical: low basicity does not lead to a reaction but high basicity leads to hydrolysis. This reactivity extends to carboxylic acid groups in a protein. The ensuing esters are hydrolyzed by human cellular esterases to regenerate protein carboxyl groups. This new mode of chemical modification could enable the key advantages of prodrugs to be translated from small-molecules to proteins. PMID:25544883

Heart Attack Coronary Artery Disease

MedlinePlus

... our e-newsletter! Aging & Health A to Z Heart Attack Coronary Artery Disease, Angina Basic Facts & Information What ... and oxygen supply; this is what causes a heart attack. If the damaged area is small, however, your ...

[Postpartal ovarian thrombophlebitis. Value of Doppler ultrasonograph y].

PubMed

Renaud-Giono, A; Giraud, J R; Poulain, P; Proudhon, J F; Grall, J Y; Moquet, P Y; Darnault, J P

1996-01-01

Thrombophlebitis of the ovarian vein is a well recognized but uncommon complication during the postpartum period. We report a small series and emphasize the contribution of color Doppler and the basic therapeutic measures.

Jobs and Employment Sourcebook. Basic Information about Employment Trends, Job Search Preparation, Legal Rights of Employees and Job Applicants, Balancing Work and Household Obligations, Vocational Education and Job Training, and Self-Employment Opportunities. Personal Concerns Series, Volume 1.

ERIC Educational Resources Information Center

Gough, Jeanne A., Ed.

This book, which is designed for the general reader who is planning to enter the job market or contemplating a career change, contains basic information about the jobs and the employment outlook; finding a job; employer and employee rights and obligations; balancing home and work; education and training; and self-employment, small business and…

Purification of a myotoxin from the toadfish Thalassophryne maculosa (Günter) venom.

PubMed

Sosa-Rosales, J I; D'Suze, G; Salazar, V; Fox, J; Sevcik, C

2005-02-01

Venom was milked by gently pressing the base of the opercular and dorsal fin spines. Three fractions were obtained by molecular exclusion high pressure liquid chromatography (HPLC) (Protein Pak 125SW, Millipore Corporation) column, but only the last one with 22.7 min retention time (rt) was biological active (TmPP-22.7). This fraction was rechromatographed on reversed phase HPLC chlorobutylsilane columns (C4, Vydac) nine fractions were obtained, but only one (TmC4-47.2) with 47.2 min rt was biologically active. MALD-TOF mass analysis was carried out on two samples of TmC-47.2 and the results were 15,161.36 and 15,154.70 a.m.u., respectively. Raw venom (1040 microg/ml) depolarised frog (Hyla crepitans) muscle irreversibly from -85 (-88, -81) mV (n=20, median and its 95% CI) to -18 (-24, -15) mV (n=24). The biological activity in TmPP-22.7 (38 microg/ml), which depolarised muscle fibres from -79 (-82, -76) mV (n=20) to -63 (-69 -57) mV (n=24). The depolarising fraction was TmC4-47.2 (50 microg/ml) which depolarised muscles from -87 (91, -82) mV (n=33) to -63 (-76 -51) mV (n=53); the depolarising effect at this concentration was completely reversed on washing with normal saline for 2 h. Muscles treated with 1 microM tetrodotoxin (TTX) were depolarised from -80 (-85, -72) mV (n=49) to -44 (-56, -31) mV (n=44) when 100 microg/ml TmC4-47.2 were applied with TTX; washing 130 min with 1 microM TTX repolarised to -59 (-69, -50) mV (n=25). We also present evidence that TmC4-47.2 induces myonecrosis in mice.

Snake-venom resistance as a mammalian trophic adaptation: lessons from didelphid marsupials.

PubMed

Voss, Robert S; Jansa, Sharon A

2012-11-01

Mammals that prey on venomous snakes include several opossums (Didelphidae), at least two hedgehogs (Erinaceidae), several mongooses (Herpestidae), several mustelids, and some skunks (Mephitidae). As a group, these taxa do not share any distinctive morphological traits. Instead, mammalian adaptations for ophiophagy seem to consist only in the ability to resist the toxic effects of snake venom. Molecular mechanisms of venom resistance (as indicated by biochemical research on opossums, mongooses, and hedgehogs) include toxin-neutralizing serum factors and adaptive changes in venom-targeted molecules. Of these, toxin-neutralizing serum factors have received the most research attention to date. All of the toxin-neutralizing serum proteins discovered so far in both opossums and mongooses are human α1B-glycoprotein homologs that inhibit either snake-venom metalloproteinases or phospholipase A(2) myotoxins. By contrast, adaptive changes in venom-targeted molecules have received far less attention. The best-documented examples include amino-acid substitutions in mongoose nicotinic acetylcholine receptor that inhibit binding by α-neurotoxins, and amino-acid substitutions in opossum von Willebrand factor (vWF) that are hypothesized to weaken the bond between vWF and coagulopathic C-type lectins. Although multiple mechanisms of venom resistance are known from some species, the proteomic complexity of most snake venoms suggests that the evolved biochemical defences of ophiophagous mammals are likely to be far more numerous than currently recognized. Whereas most previous research in this field has been motivated by the potential for medical applications, venom resistance in ophiophagous mammals is a complex adaptation that merits attention from comparative biologists. Unfortunately, evolutionary inference is currently limited by ignorance about many relevant facts that can only be provided by future research. © 2012 The Authors. Biological Reviews © 2012 Cambridge Philosophical Society.

Physicians in nonprimary care and small practices and those age 55 and older lag in adopting electronic health record systems.

PubMed

Decker, Sandra L; Jamoom, Eric W; Sisk, Jane E

2012-05-01

By 2011 more than half of all office-based physicians were using electronic health record systems, but only about one-third of those physicians had systems with basic features such as the abilities to record information on patient demographics, view laboratory and imaging results, maintain problem lists, compile clinical notes, or manage computerized prescription ordering. Basic features are considered important to realize the potential of these systems to improve health care. We found that although trends in adoption of electronic health record systems across geographic regions converged from 2002 through 2011, adoption continued to lag for non-primary care specialists, physicians age fifty-five and older, and physicians in small (1-2 providers) and physician-owned practices. Federal policies are specifically aimed at encouraging primary care providers and small practices to achieve widespread use of electronic health records. To achieve their nationwide adoption, federal policies may also have to focus on encouraging adoption among non-primary care specialists, as well as addressing persistent gaps in the use of electronic record systems by practice size, physician age, and ownership status.

SASfit: a tool for small-angle scattering data analysis using a library of analytical expressions.

PubMed

Breßler, Ingo; Kohlbrecher, Joachim; Thünemann, Andreas F

2015-10-01

SASfit is one of the mature programs for small-angle scattering data analysis and has been available for many years. This article describes the basic data processing and analysis workflow along with recent developments in the SASfit program package (version 0.94.6). They include (i) advanced algorithms for reduction of oversampled data sets, (ii) improved confidence assessment in the optimized model parameters and (iii) a flexible plug-in system for custom user-provided models. A scattering function of a mass fractal model of branched polymers in solution is provided as an example for implementing a plug-in. The new SASfit release is available for major platforms such as Windows, Linux and MacOS. To facilitate usage, it includes comprehensive indexed documentation as well as a web-based wiki for peer collaboration and online videos demonstrating basic usage. The use of SASfit is illustrated by interpretation of the small-angle X-ray scattering curves of monomodal gold nanoparticles (NIST reference material 8011) and bimodal silica nanoparticles (EU reference material ERM-FD-102).

Characteristics of the Self-evaporation Behavior of Sprinkled Water near the Triple Point

NASA Astrophysics Data System (ADS)

Aizawa, Kazuo; Hayashi, Kanetoshi; Ogoshi, Hidemasa; Maeyama, Katsuya; Yonezawa, Noriyuki

For the sake of capturing the basic data in concern with the designing of vacuum evaporation apparatus, characteristics of the self-evaporation behavior of sprinkled water near the triple point has been investigated experimentally. The relationship between the amount of the vaporized water and the pressure in the vessel was elucidated quantitatively on the condition that over-heated water was sprinkled from water supplying nozzles of diameter of 4 mm into the center of the steam area in the heat insulation glass evaporation vessel having diameter of 200 mm and height of 1100 mm. Even under the mild water sprinkling conditions such as no small particle formation, small Reynolds number, and small Weber number, the temperature effectiveness of the self-evaporation in the center of the steam was as high as 80%, which clearly shows the effectiveness of this water-sprinkling method. In addition, the basic data for system designing such as water evaporation coefficient from water layer surface and temperature effectiveness of self-evaporation during the f1ight in the steam space were obtained.

A Possible Solution to the Smallness Problem of Dark Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Pisin; /SLAC; Gu, Je-An

2005-07-08

The smallness of the dark energy density has been recognized as the most crucial difficulty in understanding dark energy and also one of the most important questions in the new century. In a recent paper[1], we proposed a new dark energy model in which the smallness of the cosmological constant is naturally achieved by invoking the Casimir energy in a supersymmetry-breaking brane-world. In this paper we review the basic notions of this model. Various implications, perspectives, and subtleties of this model are briefly discussed.

Targeted Basic Studies of Ferroelectric and Ferroelastic Materials for Piezoelectric Transducer Applications.

DTIC Science & Technology

1981-11-01

structure mixed halides in the general formula ABX 3 where A is a larger monovalent cation B is small divalent cation X the halideion are needed for extending...and cut for electrostriction measure- ments. In KCaF 3, all the crystals grown contain small opaque solid inclusions, probably CaO and attempts are now...are filled, and in many compositions all the very small C4 sites are often vacant. It is our objective to grow compositions in the system (KlxNa x)2

Proposal for a United Nations Basic Space Technology Initiative

NASA Astrophysics Data System (ADS)

Balogh, Werner

Putting space technology and its applications to work for sustainable economic and social development is the primary objective of the United Nations Programme on Space Applications, launched in 1971. A specific goal for achieving this objective is to establish a sustainable national space capacity. The traditional line of thinking has supported a logical progression from building capacity in basic space science, to using space applications and finally - possibly - to establishing indigenous space technology capabilities. The experience in some countries suggests that such a strict line of progression does not necessarily hold true and that priority given to the establishment of early indigenous space technology capabilities may contribute to promoting the operational use of space applications in support of sustainable economic and social development. Based on these findings and on the experiences with the United Nations Basic Space Science Initiative (UNBSSI) as well as on a series of United Nations/International Academy of Astronautics Workshops on Small Satellites in the Service of Developing Countries, the United Nations Office for Outer Space Affairs (UNOOSA) is considering the launch of a dedicated United Nations Basic Space Technology Initiative (UNBSTI). The initiative would aim to contribute to capacity building in basic space technology and could include, among other relevant fields, activities related to the space and ground segments of small satellites and their applications. It would also provide an international framework for enhancing cooperation between all interested actors, facilitate the exchange of information on best practices, and contribute to standardization efforts. It is expected that these activities would advance the operational use of space technology and its applications in an increasing number of space-using countries and emerging space nations. The paper reports on these initial considerations and on the potential value-adding role the United Nations could play with such an initiative.

Assessing rural small community water supply in Limpopo, South Africa: water service benchmarks and reliability.

PubMed

Majuru, Batsirai; Jagals, Paul; Hunter, Paul R

2012-10-01

Although a number of studies have reported on water supply improvements, few have simultaneously taken into account the reliability of the water services. The study aimed to assess whether upgrading water supply systems in small rural communities improved access, availability and potability of water by assessing the water services against selected benchmarks from the World Health Organisation and South African Department of Water Affairs, and to determine the impact of unreliability on the services. These benchmarks were applied in three rural communities in Limpopo, South Africa where rudimentary water supply services were being upgraded to basic services. Data were collected through structured interviews, observations and measurement, and multi-level linear regression models were used to assess the impact of water service upgrades on key outcome measures of distance to source, daily per capita water quantity and Escherichia coli count. When the basic system was operational, 72% of households met the minimum benchmarks for distance and water quantity, but only 8% met both enhanced benchmarks. During non-operational periods of the basic service, daily per capita water consumption decreased by 5.19l (p<0.001, 95% CI 4.06-6.31) and distances to water sources were 639 m further (p ≤ 0.001, 95% CI 560-718). Although both rudimentary and basic systems delivered water that met potability criteria at the sources, the quality of stored water sampled in the home was still unacceptable throughout the various service levels. These results show that basic water services can make substantial improvements to water access, availability, potability, but only if such services are reliable. Copyright © 2012 Elsevier B.V. All rights reserved.

Small-signal model for the series resonant converter

NASA Technical Reports Server (NTRS)

King, R. J.; Stuart, T. A.

1985-01-01

The results of a previous discrete-time model of the series resonant dc-dc converter are reviewed and from these a small signal dynamic model is derived. This model is valid for low frequencies and is based on the modulation of the diode conduction angle for control. The basic converter is modeled separately from its output filter to facilitate the use of these results for design purposes. Experimental results are presented.

Basic reference aids for small medical libraries.

PubMed

Blair, E D

1967-04-01

Selected primarily for the small medical library, this list is compiled to serve as a practical guide for the librarian in developing and utilizing an effective reference collection. Arrangement is by broad subject groups; titles chosen are chiefly in English with geographic coverage limited to the United States and Canada. Texts in subject fields have been omitted since these are adequately covered in several comprehensive guides to the literature.

Small Reactor for Deep Space Exploration

ScienceCinema

none,

2018-06-06

This is the first demonstration of a space nuclear reactor system to produce electricity in the United States since 1965, and an experiment demonstrated the first use of a heat pipe to cool a small nuclear reactor and then harvest the heat to power a Stirling engine at the Nevada National Security Site's Device Assembly Facility confirms basic nuclear reactor physics and heat transfer for a simple, reliable space power system.

California bypass study : the economic impacts of bypasses.

DOT National Transportation Integrated Search

2006-05-01

The California Department of Transportation (Caltrans) sponsored the California : Bypass Study to improve basic knowledge about the impacts of bypasses on small-town : economies. The study included an investigation into the economic impacts of recent...

29 CFR 780.703 - Basic requirements for exemption.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Employment by Small Country Elevators Within Area of Production; Exemption From Overtime Pay Requirements... “employed by” such establishment, and (2) Be employed “within the area of production,” as defined by the...

Three-phase Discussion Sessions.

ERIC Educational Resources Information Center

Karr, M. C.; And Others

1988-01-01

Describes the procedures, organizational pattern and design of basic soils course used by teaching assistants. Cites studies which support small-group discussion for promoting higher levels of intellectual functioning. Presents tables showing survey evaluation results of this method. (RT)

Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins

PubMed Central

Levine, Martin

2011-01-01

Early childhood caries affects 28% of children aged 2–6 in the US and is not decreasing. There is a well-recognized need to identify susceptible children at birth. Caries-free adults neutralize bacterial acids in dental biofilms better than adults with severe caries. Saliva contains acidic and basic proline-rich proteins (PRPs) which attach to oral streptococci. The PRPs are encoded within a small region of chromosome 12. An acidic PRP allele (Db) protects Caucasian children from caries but is more common in African Americans. Some basic PRP allelic phenotypes have a three-fold greater frequency in caries-free adults than in those with severe caries. Early childhood caries may associate with an absence of certain basic PRP alleles which bind oral streptococci, neutralize biofilm acids, and are in linkage disequilibrium with Db in Caucasians. The encoding of basic PRP alleles is updated and a new technology for genotyping them is described. PMID:22190937

Design and construction of functional AAV vectors.

PubMed

Gray, John T; Zolotukhin, Serge

2011-01-01

Using the basic principles of molecular biology and laboratory techniques presented in this chapter, researchers should be able to create a wide variety of AAV vectors for both clinical and basic research applications. Basic vector design concepts are covered for both protein coding gene expression and small non-coding RNA gene expression cassettes. AAV plasmid vector backbones (available via AddGene) are described, along with critical sequence details for a variety of modular expression components that can be inserted as needed for specific applications. Protocols are provided for assembling the various DNA components into AAV vector plasmids in Escherichia coli, as well as for transferring these vector sequences into baculovirus genomes for large-scale production of AAV in the insect cell production system.

Research on A3 steel corrosion behavior of basic magnesium sulfate cement

NASA Astrophysics Data System (ADS)

Xing, Sainan; Wu, Chengyou; Yu, Hongfa; Jiang, Ningshan; Zhang, Wuyu

2017-11-01

In this paper, Tafel polarization technique is used to study the corrosion behavior of A3 steel basic magnesium sulfate, and then analyzing the ratio of raw materials cement, nitrites rust inhibitor and wet-dry cycle of basic magnesium sulfate corrosion of reinforced influence, and the steel corrosion behavior of basic magnesium sulfate compared with magnesium oxychloride cement and Portland cement. The results show that: the higher MgO/MgSO4 mole ratio will reduce the corrosion rate of steel; Too high and too low H2O/MgSO4 mole ratio may speed up the reinforcement corrosion effect; Adding a small amount of nitrite rust and corrosion inhibitor, not only can obviously reduce the alkali type magnesium sulfate in the early hydration of cement steel bar corrosion rate, but also can significantly reduce dry-wet circulation under the action of alkali type magnesium sulfate cement corrosion of reinforcement effect. Basic magnesium sulfate cement has excellent ability to protect reinforced, its long-term corrosion of reinforcement effect and was equal to that of Portland cement. Basic magnesium sulfate corrosion of reinforced is far below the level in the MOC in the case.

Radionuclide Basics: Americium-241

EPA Pesticide Factsheets

Americium (chemical symbol Am) is a man-made radioactive metal that is solid under normal conditions. Exposure to a significant amount of Am-241 is generally unlikely. Small amounts are found in the soil, plants and water from nuclear weapons testing.

Patterns-Based IS Change Management in SMEs

NASA Astrophysics Data System (ADS)

Makna, Janis; Kirikova, Marite

The majority of information systems change management guidelines and standards are either too abstract or too bureaucratic to be easily applicable in small enterprises. This chapter proposes the approach, the method, and the prototype that are designed especially for information systems change management in small and medium enterprises. The approach is based on proven patterns of changes in the set of information systems elements. The set of elements was obtained by theoretical analysis of information systems and business process definitions and enterprise architectures. The patterns were evolved from a number of information systems theories and tested in 48 information systems change management projects. The prototype presents and helps to handle three basic change patterns, which help to anticipate the overall scope of changes related to particular elementary changes in an enterprise information system. The use of prototype requires just basic knowledge in organizational business process and information management.

Vibration-based structural health monitoring of the aircraft large component

NASA Astrophysics Data System (ADS)

Pavelko, V.; Kuznetsov, S.; Nevsky, A.; Marinbah, M.

2017-10-01

In the presented paper there are investigated the basic problems of the local system of SHM of large scale aircraft component. Vibration-based damage detection is accepted as a basic condition, and main attention focused to a low-cost solution that would be attractive for practice. The conditions of small damage detection in the full scale structural component at low-frequency excitation were defined in analytical study and modal FEA. In experimental study the dynamic test of the helicopter Mi-8 tail beam was performed at harmonic excitation with frequency close to first natural frequency of the beam. The index of correlation coefficient deviation (CCD) was used for extraction of the features due to embedded pseudo-damage. It is shown that the problem of vibration-based detection of a small damage in the large scale structure at low-frequency excitation can be solved successfully.

Professional, Organizational, and Training Weaknesses in Small Purchase within the Department of the Navy

DTIC Science & Technology

1984-06-01

attempt to take a leading role in the develcrzen’ of a basic perfcrmance appraisal system for field level activities. Such a system should be flrxible...the small purchase environment. Buyers desire that suiervisors take an active role in recognizing the achievemerts of individual buyers, and...organizational resources necessary to * indep •ed•ntly verify data included on reguests. c . Summary cl Solutions "The researchers recommend that refresler

Human papillomavirus molecular biology.

PubMed

Harden, Mallory E; Munger, Karl

Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses. Copyright © 2016 Elsevier B.V. All rights reserved.

Multigrid finite element method in stress analysis of three-dimensional elastic bodies of heterogeneous structure

NASA Astrophysics Data System (ADS)

Matveev, A. D.

2016-11-01

To calculate the three-dimensional elastic body of heterogeneous structure under static loading, a method of multigrid finite element is provided, when implemented on the basis of algorithms of finite element method (FEM), using homogeneous and composite threedimensional multigrid finite elements (MFE). Peculiarities and differences of MFE from the currently available finite elements (FE) are to develop composite MFE (without increasing their dimensions), arbitrarily small basic partition of composite solids consisting of single-grid homogeneous FE of the first order can be used, i.e. in fact, to use micro approach in finite element form. These small partitions allow one to take into account in MFE, i.e. in the basic discrete models of composite solids, complex heterogeneous and microscopically inhomogeneous structure, shape, the complex nature of the loading and fixation and describe arbitrarily closely the stress and stain state by the equations of three-dimensional elastic theory without any additional simplifying hypotheses. When building the m grid FE, m of nested grids is used. The fine grid is generated by a basic partition of MFE, the other m —1 large grids are applied to reduce MFE dimensionality, when m is increased, MFE dimensionality becomes smaller. The procedures of developing MFE of rectangular parallelepiped, irregular shape, plate and beam types are given. MFE generate the small dimensional discrete models and numerical solutions with a high accuracy. An example of calculating the laminated plate, using three-dimensional 3-grid FE and the reference discrete model is given, with that having 2.2 milliards of FEM nodal unknowns.

Description of the small plastics fragments in marine sediments along the Alang-Sosiya ship-breaking yard, India

NASA Astrophysics Data System (ADS)

Srinivasa Reddy, M.; Basha, Shaik; Adimurthy, S.; Ramachandraiah, G.

2006-07-01

This study aimed to assess the accumulation of small plastic debris in the intertidal sediments of the world's largest ship-breaking yard at Alang-Sosiya, India. Small plastics fragments were collected by flotation and separated according to their basic polymer type under a microscope, and subsequently identified by FT-IR spectroscopy as polyurethane, nylon, polystyrene, polyester and glass wool. The morphology of these materials was also studied using a scanning electron microscope. Overall, there were on average 81 mg of small plastics fragments per kg of sediment. The described plastic fragments are believed to have resulted directly from the ship-breaking activities at the site.

SCP -- A Simple CCD Processing Package

NASA Astrophysics Data System (ADS)

Lewis, J. R.

This note describes a small set of programs, written at RGO, which deal with basic CCD frame processing (e.g. bias subtraction, flat fielding, trimming etc.). The need to process large numbers of CCD frames from devices such as FOS or ISIS in order to extract spectra has prompted the writing of routines which will do the basic hack-work with a minimal amount of interaction from the user. Although they were written with spectral data in mind, there are no ``spectrum-specific'' features in the software which means they can be applied to any CCD data.

Passive Reactive Berm (PRBerm) to Provide Low Maintenance Lead Containment at Active Small Arms Firing Ranges

DTIC Science & Technology

2012-01-01

body, dissolved Pb forms precipitates of Pb hydroxide [Pb(OH)2], Pb carbonate [PbCO3, cerrusite], or basic Pb carbonate [Pb3(OH)2 ( CO3 )2...along with a potential seed crystal for heterogeneous nucleation of Pb-pyromorphites (Wright et al., 2004). Depending on the presence of certain... single steel bullet trap. The sand or dirt berm is the oldest and most basic type of bullet trap. It uses the mass of the berm itself to stop and

User's guide to the LLL BASIC interpreter. [For 8080-based MCS-80 microcomputer system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allison, T.; Eckard, R.; Barber, J.

1977-06-09

Scientists are finding increased applications for microcomputers as process controllers in their experiments. However, while microcomputers are small and inexpensive, they are difficult to program in machine or assembly language. A high-level language is needed to enable scientists to develop their own microcomputer programs for their experiments on location. Recognizing this need, LLL contracted to have such a language developed. This report describes the result--the LLL BASIC interpreter, which operates with LLL's 8080-based MCS-80 microcomputer system. 4 tables.

Electro-Mechanical Curriculum.

ERIC Educational Resources Information Center

EASTCONN Regional Educational Services Center, North Windham, CT.

This electromechanical technician curriculum covers the following general areas: (1) basic soldering; (2) reading diagrams and following schematics; and (3) repairing circuitry and mechanics common to major appliances, vending machines, amusement equipment, and small office machines. The manual includes the following sections: (1) course…

Effect of Varient Dosages of Amphetamine Upon Endurance

ERIC Educational Resources Information Center

Williams, Melvin H.; Thompson, John

1973-01-01

This study sought to provide basic information concerning the acute effects of a small, moderate, and large dose of d-amphetamine sulfate upon muscular endurance; a secondary purpose involved the effect upon submaximal and maximal heart rate. (Author/JA)

Design and performance characteristics of a mechanically driven vestibular stimulator.

DOT National Transportation Integrated Search

1964-01-01

In order to determine basic response characteristics of mammalian vestibular systems, the sytems so important for spatial orientation, a device to provide programs of controlled angular accelerations about the vertical axis was required. The small ro...

75 FR 32487 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... Panel; Small Business: Biological Chemistry and Biophysics. Date: June 28-29, 2010. Time: 8 a.m. to 5 p... Emphasis Panel; ARRA: RFA-OD-10-003--Career Development Awards in the Basic Behavioral and Social Sciences...

Efficient linear algebra routines for symmetric matrices stored in packed form.

PubMed

Ahlrichs, Reinhart; Tsereteli, Kakha

2002-01-30

Quantum chemistry methods require various linear algebra routines for symmetric matrices, for example, diagonalization or Cholesky decomposition for positive matrices. We present a small set of these basic routines that are efficient and minimize memory requirements.

Occupational health and safety in small animal veterinary practice: Part I--nonparasitic zoonotic diseases.

PubMed

Weese, J S; Peregrine, A S; Armstrong, J

2002-08-01

Zoonotic diseases are an ever-present concern in small animal veterinary practice and are often overlooked. A variety of nonparasitic zoonotic diseases may be encountered in small animal practice, including cat scratch disease (bartonellosis), cat bite abscesses, rabies, leptospirosis, methicillin-resistant Staphylococcus aureus, Clostridium difficile-associated diarrhea, salmonellosis, avian chlamydiosis, campylobacteriosis, dermatophytosis, and blastomycosis. These may cause human disease ranging from mild and self-limiting to fatal. The risk of development of a zoonotic disease can be lessened by early recognition of infected animals, proper animal handling, basic biosecurity precautions, and, most importantly, personal hygiene.

Photovoltaic Research in the Small Business Innovative Research Program

NASA Astrophysics Data System (ADS)

Bower, Ward I.; Bulawka, Alec

1997-02-01

The Small Business Innovative Research Program (SBIR) is currently authorized to be funded through September 30, 2000. The National Photovoltaics Program is a contributor to the Department of Energy (DOE) SBIR program. The small business photovoltaic industry has been benefiting from the SBIR program through awards that have funded basic research, new processes and products that have PV and other commercial applications. This paper provides information on SBIR opportunities, selected details of the SBIR program, statistics from the 1995 and 1996 DOE SBIR program, and methods for improving PV industry participation and success in the SBIR program.

Effects of Robot-Assisted Therapy for the Upper Limb After Stroke.

PubMed

Veerbeek, Janne M; Langbroek-Amersfoort, Anneli C; van Wegen, Erwin E H; Meskers, Carel G M; Kwakkel, Gert

2017-02-01

Robot technology for poststroke rehabilitation is developing rapidly. A number of new randomized controlled trials (RCTs) have investigated the effects of robot-assisted therapy for the paretic upper limb (RT-UL). To systematically review the effects of poststroke RT-UL on measures of motor control of the paretic arm, muscle strength and tone, upper limb capacity, and basic activities of daily living (ADL) in comparison with nonrobotic treatment. Relevant RCTs were identified in electronic searches. Meta-analyses were performed for measures of motor control (eg, Fugl-Meyer Assessment of the arm; FMA arm), muscle strength and tone, upper limb capacity, and basic ADL. Subgroup analyses were applied for the number of joints involved, robot type, timing poststroke, and treatment contrast. Forty-four RCTs (N = 1362) were included. No serious adverse events were reported. Meta-analyses of 38 trials (N = 1206) showed significant but small improvements in motor control (~2 points FMA arm) and muscle strength of the paretic arm and a negative effect on muscle tone. No effects were found for upper limb capacity and basic ADL. Shoulder/elbow robotics showed small but significant effects on motor control and muscle strength, while elbow/wrist robotics had small but significant effects on motor control. RT-UL allows patients to increase the number of repetitions and hence intensity of practice poststroke, and appears to be a safe therapy. Effects on motor control are small and specific to the joints targeted by RT-UL, whereas no generalization is found to improvements in upper limb capacity. The impact of RT-UL started in the first weeks poststroke remains unclear. These limited findings could mainly be related to poor understanding of robot-induced motor learning as well as inadequate designing of RT-UL trials, by not applying an appropriate selection of stroke patients with a potential to recovery at baseline as well as the lack of fixed timing of baseline assessments and using an insufficient treatment contrast early poststroke.

Circumstellar Matter Studied by Spectrally-Resolved Interferometry

NASA Astrophysics Data System (ADS)

Millour, F.

2012-12-01

This paper describes some generalities about spectro-interferometry and the role it has played in the last decade for the better understanding of circumstellar matter. I provide a small history of the technique and its origins, and recall the basics of differential phase and its central role for the recent discoveries. I finally provide a small set of simple interpretations of differential phases for specific astrophysical cases, and intend to provide a "cookbook" for the other cases.

Navy Littoral Combat Ship (LCS) Program: Oversight Issues and Options for Congress

DTIC Science & Technology

2007-06-11

Summary The Littoral Combat Ship (LCS) is a small, fast ship that uses modular “plug- and-fight” mission packages, including unmanned vehicles (UVs). The...small, fast ship that uses modular “plug-and- fight” mission packages, including unmanned vehicles (UVs). The basic version of the LCS, without any...including unmanned vehicles (UVs). Rather than being a multimission ship like the Navy’s current large surface combatants, the LCS is a focused-mission ship

Contract Funding Opportunities Available for Innovative SBIR Development | Office of Cancer Clinical Proteomics Research

Cancer.gov

Does your small business need early-stage financing to take its cancer research to the next level? The National Cancer Institute Small Business Innovation Research (NCI SBIR) Development Center has released $5 million for new contract funding opportunities to support cancer research and technology development in key emerging areas of need. The NCI SBIR can help you finance and advance innovations in cancer prevention, diagnosis, treatment, and basic research.

Development of a Course of Training Programs for Young Engineers at Work to Nurture the “Basic Competencies of Employees”

NASA Astrophysics Data System (ADS)

Itoh, Michiko; Jomura, Makoto; Hongo, Tetsuyuki; Chohji, Tetsuji

According to our feasibility study in 2005, many of small and medium-sized companies in and around Toyama city asked their young engineers for originality and strong will to try and solve problems positively in their workplaces. These skills have a lot in common with “Basic Competencies of Employees” advocated by the Ministry of Economy, Trade and Industry, Japan. Since Toyama National College of Technology has an accumulated educational know-how to nurture “Basic Competencies of Employees” , we have applied this to develop a course of training programs for young engineers. Through four year‧s practice and improvement, we have established and evaluated this training course. We show the details of our course in this report.

Perturbed effects at radiation physics

NASA Astrophysics Data System (ADS)

Külahcı, Fatih; Şen, Zekâi

2013-09-01

Perturbation methodology is applied in order to assess the linear attenuation coefficient, mass attenuation coefficient and cross-section behavior with random components in the basic variables such as the radiation amounts frequently used in the radiation physics and chemistry. Additionally, layer attenuation coefficient (LAC) and perturbed LAC (PLAC) are proposed for different contact materials. Perturbation methodology provides opportunity to obtain results with random deviations from the average behavior of each variable that enters the whole mathematical expression. The basic photon intensity variation expression as the inverse exponential power law (as Beer-Lambert's law) is adopted for perturbation method exposition. Perturbed results are presented not only in terms of the mean but additionally the standard deviation and the correlation coefficients. Such perturbation expressions provide one to assess small random variability in basic variables.

Remediation for Students With Mathematics Difficulties: An Intervention Study in Middle Schools.

PubMed

Moser Opitz, Elisabeth; Freesemann, Okka; Prediger, Susanne; Grob, Urs; Matull, Ina; Hußmann, Stephan

As empirical studies have consistently shown, low achievement in mathematics at the secondary level can often be traced to deficits in the understanding of certain basic arithmetic concepts taught in primary school. The present intervention study in middle schools evaluated whether such learning deficits can be reduced effectively and whether the type of instruction influences students' progress. The sample consisted of 123 students in 34 classes, split among one control group and two intervention groups: (a) small group instruction and (b) independent work partially integrated into regular classrooms. Over a period of 14 weeks, students were taught basic concepts, such as place value and basic operations. In addition, they practiced fact retrieval and counting (in groups). Multilevel regression analyses demonstrated that the interventions can be used to reduce given deficits.

Creating Energy for Change.

ERIC Educational Resources Information Center

Neiman, Robert A.

2002-01-01

Describes the use of small-scale change projects by Philadelphia's Department of Human Services to generate new outcomes and new skills and experience that improved basic day-to-day operations, strategic planning, and cumulatively produced larger-scale changes in service, financing, and performance. (Author/LRW)

RESTRAINING SYSTEM FOR PLETHYSMOGRAPHY IN SMALL ANIMALS

EPA Science Inventory

A restraining technique for immobilizing awake guinea pigs and rats during physiological measurements is described. The basic device consists of an adjustable acrylic holder that supports the animal in a standing position while restricting movement of the four legs. The holder al...

A method of developing and introducing case-based learning to a preclinical veterinary curriculum.

PubMed

Crowther, Emma; Baillie, Sarah

2016-01-01

Case-based learning (CBL) has been introduced as part of a major review of the veterinary curriculum at the University of Bristol. The initial aim was to improve integration between all first year subjects, i.e., basic science disciplines (anatomy, physiology, and biochemistry), animal management, and professional studies, while highlighting the relevance by providing clinical context. The CBL was delivered as whole class sessions in a lecture theatre, as small group teaching facilities were not readily available, co-facilitated by two to four basic scientists and clinicians. Active learning tasks were included by using an audience response system and encouraging discussion. A case template was developed in PowerPoint and then populated by basic science and clinical staff in an iterative design process. Comments from a student focus group informed the design of the case sessions. Feedback collected from students via a survey after the first three cases suggested that CBL was well received and assisted students in integrating material taught in the first year units and was used to further improve the ongoing case design. The project team developed eight cases for Year 1 and is implementing CBL in various formats throughout the curriculum. There was a considerable time commitment in developing each case; however, the use of readily available software and the large group format overcame limitations, including resourcing small group sessions. This article reports a model that could be successfully adapted by other institutions wishing to use CBL to provide clinical context and promote integration of the basic sciences. © 2015 American Association of Anatomists.

A case-based, small-group cooperative learning course in preclinical veterinary science aimed at bridging basic science and clinical literacy.

PubMed

Schoeman, J P; van Schoor, M; van der Merwe, L L; Meintjes, R A

2009-03-01

In 1999 a dedicated problem-based learning course was introduced into the lecture-based preclinical veterinary curriculum of the University of Pretoria. The Introduction to Clinical Studies Course combines traditional lectures, practical sessions, student self-learning and guided tutorials. The self-directed component of the course utilises case-based, small-group cooperative learning as an educational vehicle to link basic science with clinical medicine. The aim of this article is to describe the objectives and structure of the course and to report the results of the assessment of the students' perceptions on some aspects of the course. Students reacted very positively to the ability of the course to equip them with problem-solving skills. Students indicated positive perceptions about the workload of the course. There were, however, significantly lower scores for the clarity of the course objectives. Although the study guide for the course is very comprehensive, the practice regarding the objectives is still uncertain. It is imperative to set clear objectives in non-traditional, student-centred courses. The objectives have to be explained at the outset and reiterated throughout the course. Tutors should also communicate the rationale behind problem-based learning as a pedagogical method to the students. Further research is needed to verify the effectiveness of this course in bridging the gap between basic science and clinical literacy in veterinary science. Ongoing feedback and assessment of the management and content are important to refine this model for integrating basic science with clinical literacy.

Application of phase-trafficking methods to natural products research.

PubMed

Araya, Juan J; Montenegro, Gloria; Mitscher, Lester A; Timmermann, Barbara N

2010-09-24

A novel simultaneous phase-trafficking approach using spatially separated solid-supported reagents for rapid separation of neutral, basic, and acidic compounds from organic plant extracts with minimum labor is reported. Acidic and basic ion-exchange resins were physically separated into individual sacks ("tea bags") for trapping basic and acidic compounds, respectively, leaving behind in solution neutral components of the natural mixtures. Trapped compounds were then recovered from solid phase by appropriate suspension in acidic or basic solutions. The feasibility of the proposed separation protocol was demonstrated and optimized with an "artificial mixture" of model compounds. In addition, the utility of this methodology was illustrated with the successful separation of the alkaloid skytanthine from Skytanthus acutus Meyen and the main catechins and caffeine from Camellia sinensis L. (Kuntze). This novel approach offers multiple advantages over traditional extraction methods, as it is not labor intensive, makes use of only small quantities of solvents, produces fractions in adequate quantities for biological assays, and can be easily adapted to field conditions for bioprospecting activities.

Application of Phase-Trafficking Methods to Natural Products Research

PubMed Central

Araya, Juan J.; Montenegro, Gloria; Mitscher, Lester A.; Timmermann, Barbara N.

2010-01-01

A novel simultaneous phase-trafficking approach using spatially separated solid-supported reagents (SSR) for rapid separation of neutral, basic, and acidic compounds from organic plant extracts with minimum labor is reported. Acidic and basic ion exchange resins were physically separated into individual sacks (“teabags”) for trapping basic and acidic compounds respectively, leaving behind in solution neutral components of the natural mixtures. Trapped compounds were then recovered from solid phase by appropriate suspension in acidic or basic solutions. The feasibility of the proposed separation protocol was demonstrated and optimized with an “artificial mixture” of model compounds. In addition, the utility of this methodology was illustrated with the successful separation of the alkaloid skytanthine from Skytanthus acutus Meyen and the main catechins and caffeine from Camellia sinensis L. (Kuntze). This novel approach offers multiple advantages over traditional extraction methods, as it is not labor intensive, makes use of only small quantities of solvents, produces fractions in adequate quantities for biological assays, and can be easily adapted to field conditions for bioprospecting activities. PMID:20704309

Compliant leg behaviour explains basic dynamics of walking and running

PubMed Central

Geyer, Hartmut; Seyfarth, Andre; Blickhan, Reinhard

2006-01-01

The basic mechanics of human locomotion are associated with vaulting over stiff legs in walking and rebounding on compliant legs in running. However, while rebounding legs well explain the stance dynamics of running, stiff legs cannot reproduce that of walking. With a simple bipedal spring–mass model, we show that not stiff but compliant legs are essential to obtain the basic walking mechanics; incorporating the double support as an essential part of the walking motion, the model reproduces the characteristic stance dynamics that result in the observed small vertical oscillation of the body and the observed out-of-phase changes in forward kinetic and gravitational potential energies. Exploring the parameter space of this model, we further show that it not only combines the basic dynamics of walking and running in one mechanical system, but also reveals these gaits to be just two out of the many solutions to legged locomotion offered by compliant leg behaviour and accessed by energy or speed. PMID:17015312

Decent wage is more important than absolution of debts: A smallholder socio-hydrological modelling framework

NASA Astrophysics Data System (ADS)

Pande, Saket; Savenije, Hubert

2015-04-01

We present a framework to understand the socio-hydrological system dynamics of a small holder. Small holders are farmers who own less than 2 ha of farmland. It couples the dynamics of 6 main variables that are most relevant at the scale of a small holder: local storage (soil moisture and other water storage), capital, knowledge, livestock production, soil fertility and grass biomass production. The hydroclimatic variability is at sub-annual scale and influences the socio-hydrology at annual scale. The model incorporates rule-based adaptation mechanisms (for example: adjusting expenditures on food and fertilizers, selling livestocks etc.) of small holders when they face adverse socio-hydrological conditions, such as low annual rainfall, higher intra-annual variability in rainfall or variability in agricultural prices. We apply the framework to understand the socio-hydrology of a sugarcane small holder in Aurangabad, Maharashtra. This district has witnessed suicides of many sugarcane farmers who could not extricate themselves out of the debt trap. These farmers lack irrigation and are susceptible to fluctuating sugar prices and intra-annual hydro-climatic variability. We study the sensitivity of annual total capital averaged over 30 years, an indicator of small holder wellbeing, to initial capital that a small holder starts with and the prevalent wage rates. We find that a smallholder well being is low (below Rs 30000 per annum, a threshold above which a smallholder can afford a basic standard of living) and is rather insensitive to initial capital at low wage rates. Initial capital perhaps matters to small holder livelihoods at higher wage rates. Further, the small holder system appears to be resilient at around Rs 115/mandays in the sense that small perturbations in wage rates around this rate still sustains the smallholder above the basic standard of living. Our results thus indicate that government intervention to absolve the debt of farmers is not enough. It must invest in local storages that can buffer intra-annual variability in rainfall in tandem and good wages for alternative sources of income.

Communication Competence among Teachers: The Ohio Solution.

ERIC Educational Resources Information Center

DeWine, Sue; Pearson, Judy C.

1989-01-01

Describes a summer instructional program for elementary and secondary teachers involving a set of workshops on basic communication concepts, nonverbal communication, organizational communication, listening, and small group communication. Discusses issues of marketing the program, defending its academic validity, and decreasing the gap between the…

Radionuclide Basics: Technetium-99

EPA Pesticide Factsheets

Technetium-99 (chemical symbol Tc-99) is a silver-gray, radioactive metal. It occurs naturally in very small amounts in the earth's crust, but is primarily man-made. Technetium-99m is a short-lived form of Tc-99 that is used as a medical diagnostic tool.

Universities for a Small Planet--A Time to Reconceptualize Our Role.

ERIC Educational Resources Information Center

Wallin, Franklin W.

1983-01-01

The modern world is characterized by global interdependence and a shift in society to information as the basic resource. The amount and quality of education required to be functionally literate in an information-based society will keep growing. (MLW)

Variation in pollen competitive ability in diverse maize lines

EPA Science Inventory

Although pollen occupies a small fraction of the angiosperm life cycle, it is of interest for both basic and applied scientific reasons. Seed production depends on a functional male gametophyte achieving fertilization following pollination. Pollen also serves as a vector for ge...

Heart-rate pulse-shift detector

NASA Technical Reports Server (NTRS)

Anderson, M.

1974-01-01

Detector circuit accurately separates and counts phase-shift pulses over wide range of basic pulse-rate frequency, and also provides reasonable representation of full repetitive EKG waveform. Single telemeter implanted in small animal monitors not only body temperature but also animal movement and heart rate.

The Educationally Challenged American School District.

ERIC Educational Resources Information Center

Clinchy, Evans

1998-01-01

Two national reform movements--one focused on creating small, autonomous schools, the other fixated on a standardization agenda--are basically in conflict. The standards movement is touting the traditional, top-down, centralized, bureaucratic system modeled after Frederick Taylor and his efficiency experts. Progressive, decentralized initiatives…

Small space station electrical power system design concepts

NASA Technical Reports Server (NTRS)

Jones, G. M.; Mercer, L. N.

1976-01-01

A small manned facility, i.e., a small space station, placed in earth orbit by the Shuttle transportation system would be a viable, cost effective addition to the basic Shuttle system to provide many opportunities for R&D programs, particularly in the area of earth applications. The small space station would have many similarities with Skylab. This paper presents design concepts for an electrical power system (EPS) for the small space station based on Skylab experience, in-house work at Marshall Space Flight Center, SEPS (Solar Electric Propulsion Stage) solar array development studies, and other studies sponsored by MSFC. The proposed EPS would be a solar array/secondary battery system. Design concepts expressed are based on maximizing system efficiency and five year operational reliability. Cost, weight, volume, and complexity considerations are inherent in the concepts presented. A small space station EPS based on these concepts would be highly efficient, reliable, and relatively inexpensive.

Introduction to clinical and laboratory (small-animal) image registration and fusion.

PubMed

Zanzonico, Pat B; Nehmeh, Sadek A

2006-01-01

Imaging has long been a vital component of clinical medicine and, increasingly, of biomedical research in small-animals. Clinical and laboratory imaging modalities can be divided into two general categories, structural (or anatomical) and functional (or physiological). The latter, in particular, has spawned what has come to be known as "molecular imaging". Image registration and fusion have rapidly emerged as invaluable components of both clinical and small-animal imaging and has lead to the development and marketing of a variety of multi-modality, e.g. PET-CT, devices which provide registered and fused three-dimensional image sets. This paper briefly reviews the basics of image registration and fusion and available clinical and small-animal multi-modality instrumentation.

Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines.

PubMed

Gomes, P; Soares-da-Silva, P

2002-03-15

The present study examined the functional characteristics of L-DOPA transporters in two functionally different clonal subpopulations of opossum kidney (OKLC and OKHC) cells. The uptake of L-DOPA was largely Na+-independent, though in OKHC cells a minor component (approximately 15%) required extracellular Na+. At least two Na+-independent transporters appear to be involved in L-DOPA uptake. One of these transporters has a broad specificity for small and large neutral amino acids, is stimulated by acid pH and inhibited by 2-aminobicyclo(2,2,l)-heptane-2-carboxylic acid (BCH; OKLC, Ki = 291 mM; OKHC, Ki = 380 mM). The other Na+-independent transporter binds neutral and basic amino acids and also recognizes the di-amino acid cystine. [14C]-L-DOPA efflux from OKLC and OKHC cells over 12 min corresponded to a small amount of intracellular [14C]-L-DOPA. L-Leucine, nonlabelled L-DOPA, BCH and L-arginine, stimulated the efflux of [14C]-L-DOPA in a Na+-independent manner. It is suggested that L-DOPA uses at least two major transporters, systems LAT-2 and b0,+. The transport of L-DOPA by LAT-2 corresponds to a Na+-independent transporter with a broad specificity for small and large neutral amino acids, stimulated by acid pH and inhibited by BCH. The transport of L-DOPA by system b0,+ is a Na+-independent transporter for neutral and basic amino acids that also recognizes cystine. LAT-2 was found equally important at the apical and basolateral membranes, whereas system b0,+ had a predominant distribution in apical membranes.

Short-term change in physical function and disability: the Women's Health and Aging Study.

PubMed

Mendes de Leon, Carlos F; Guralnik, Jack M; Bandeen-Roche, Karen

2002-11-01

Although measures of physical function are predictive of future disability, little is known about the short-term impact of changes in physical function on disability. Data from 93 of the 102 women who participated in the Weekly Substudy of the Women's Health and Aging Study (WHAS) were used to explore the association of changes in physical function with disability. The WHAS Substudy included 24 weekly assessments of three standard performance tests and self-reported disability in activities of daily living (ADLs) and basic mobility. Using random-effects models, we found small but significant (ps <.01) changes in ADL and mobility disability during weekly follow-up. Baseline performance scores were significantly associated with both ADL and mobility disability (ps <.001), accounting for 27% and 36% of the between-person variability in each type of disability, respectively. After adjustment for baseline scores, change in performance scores was significantly associated with ADL disability (beta = 0.08, p <.01) and mobility disability (beta = 0.12, p <.001), but accounted only for a small proportion (<10%) of the variability in the rate of change in disability outcomes. There was no evidence for an additional effect on either type of disability because of having a single episode of a higher or lower than usual performance score, or because of periods of at least 4 consecutive higher or lower than usual performance test scores. Basic physical functions account for a substantial proportion of the heterogeneity in ADL and mobility disability among older disabled women, but have a relatively small impact on short-term changes in either type of disability. Effective prevention of disability may require attention to a wider array of risk factors than just limitations in basic physical functions.

The flight of a balsa glider

NASA Astrophysics Data System (ADS)

Waltham, Chris

1999-07-01

A simple analysis is performed on the flight of a small balsa toy glider. All the basic features of flight have to be included in the calculation. Key differences between the flight of small objects like the glider, and full-sized aircraft, are examined. Good agreement with experimental data is obtained when only one parameter, the drag coefficient, is allowed to vary. The experimental drag coefficient is found to be within a factor of 2 of that obtained using the theory of ideal flat plates.

Cooperative Lewis pairs based on late transition metals: activation of small molecules by platinum(0) and B(C6 F5 )3.

PubMed

Forrest, Sebastian J K; Clifton, Jamie; Fey, Natalie; Pringle, Paul G; Sparkes, Hazel A; Wass, Duncan F

2015-02-09

A Lewis basic platinum(0)-CO complex supported by a diphosphine ligand and B(C6 F5 )3 act cooperatively, in a manner reminiscent of a frustrated Lewis pair, to activate small molecules such as hydrogen, CO2 , and ethene. This cooperative Lewis pair facilitates the coupling of CO and ethene in a new way. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The dispersion of age differences between partners and the asymptotic dynamics of the HIV epidemic.

PubMed

d'Albis, Hippolyte; Augeraud-Véron, Emmanuelle; Djemai, Elodie; Ducrot, Arnaud

2012-01-01

In this paper, the effect of a change in the distribution of age differences between sexual partners on the dynamics of the HIV epidemic is studied. In a gender- and age-structured compartmental model, it is shown that if the variance of the distribution is small enough, an increase in this variance strongly increases the basic reproduction number. Moreover, if the variance is large enough, the mean age difference barely affects the basic reproduction number. We, therefore, conclude that the local stability of the disease-free equilibrium relies more on the variance than on the mean.

A Curriculum for Adult Education.

ERIC Educational Resources Information Center

Pattanayak, D. P.

1978-01-01

The author discusses factors inhibiting adult literacy in India, stating that institutional schooling has provided education for only a small percentage of the population. As an adult literacy curriculum depends on community needs, he suggests a core or minimum curriculum for adult basic education in the community. (MF)

Music Education Suites

ERIC Educational Resources Information Center

Kemp, Wayne

2009-01-01

This publication describes options for designing and equipping middle and high school music education suites, and suggests ways of gaining community support for including full service music suites in new and renovated school facilities. In addition to basic music suites, and practice rooms, other options detailed include: (1) small ensemble…

Federal Aviation Administration Small Business Innovation Research 5- Year Project Summaries

DTIC Science & Technology

1990-02-01

Completed Project: The project’s two primary objectives were to further develop the technology base for the Slaved Tandem Freewing (STF) Airplance and...margins than conventional airplances , and can meet all applicable airworthiness requirements. Adaitionally, basic design parameters were developed

Garnet Random-Access Memory

NASA Technical Reports Server (NTRS)

Katti, Romney R.

1995-01-01

Random-access memory (RAM) devices of proposed type exploit magneto-optical properties of magnetic garnets exhibiting perpendicular anisotropy. Magnetic writing and optical readout used. Provides nonvolatile storage and resists damage by ionizing radiation. Because of basic architecture and pinout requirements, most likely useful as small-capacity memory devices.

The Challenge of Urban Policy

ERIC Educational Resources Information Center

Glaeser, Edward L.

2012-01-01

Urbanization almost invariably accompanies development, and the cities of India and China are experiencing spectacular increases in population. The concentration of millions of people in a small mass creates challenges for public policy, especially in the areas of basic infrastructure, public health, traffic congestion, and often law enforcement…

Music Education Suites.

ERIC Educational Resources Information Center

Kemp, Wayne

This publication describes options for designing and equipping middle and high school music education suites and suggests means of gaining community support for including full service music suites in new and renovated facilities. It covers the basic music suite, practice rooms, small ensemble rehearsal rooms, recording/MIDI (musical instrument…

Versatile photonic microwave waveforms generation using a dual-parallel Mach-Zehnder modulator without other dispersive elements

NASA Astrophysics Data System (ADS)

Bai, Guang-Fu; Hu, Lin; Jiang, Yang; Tian, Jing; Zi, Yue-Jiao; Wu, Ting-Wei; Huang, Feng-Qin

2017-08-01

In this paper, a photonic microwave waveform generator based on a dual-parallel Mach-Zehnder modulator is proposed and experimentally demonstrated. In this reported scheme, only one radio frequency signal is used to drive the dual-parallel Mach-Zehnder modulator. Meanwhile, dispersive elements or filters are not required in the proposed scheme, which make the scheme simpler and more stable. In this way, six variables can be adjusted. Through the different combinations of these variables, basic waveforms with full duty and small duty cycle can be generated. Tunability of the generator can be achieved by adjusting the frequency of the RF signal and the optical carrier. The corresponding theoretical analysis and simulation have been conducted. With guidance of theory and simulation, proof-of-concept experiments are carried out. The basic waveforms, including Gaussian, saw-up, and saw-down waveforms, with full duty and small duty cycle are generated at the repetition rate of 2 GHz. The theoretical and simulation results agree with the experimental results very well.

Small Molecule Docking from Theoretical Structural Models

NASA Astrophysics Data System (ADS)

Novoa, Eva Maria; de Pouplana, Lluis Ribas; Orozco, Modesto

Structural approaches to rational drug design rely on the basic assumption that pharmacological activity requires, as necessary but not sufficient condition, the binding of a drug to one or several cellular targets, proteins in most cases. The traditional paradigm assumes that drugs that interact only with a single cellular target are specific and accordingly have little secondary effects, while promiscuous molecules are more likely to generate undesirable side effects. However, current examples indicate that often efficient drugs are able to interact with several biological targets [1] and in fact some dirty drugs, such as chlorpromazine, dextromethorphan, and ibogaine exhibit desired pharmacological properties [2]. These considerations highlight the tremendous difficulty of designing small molecules that both have satisfactory ADME properties and the ability of interacting with a limited set of target proteins with a high affinity, avoiding at the same time undesirable interactions with other proteins. In this complex and challenging scenario, computer simulations emerge as the basic tool to guide medicinal chemists during the drug discovery process.

Recruitment and Retention of New Emergency Medical Technician (EMT)-Basics and Paramedics.

PubMed

Chapman, Susan A; Crowe, Remle P; Bentley, Melissa A

2016-12-01

The purpose of this paper is to describe factors important for the recruitment and retention of Emergency Medical Technician (EMT)-Basics and EMT-Paramedics new to the Emergency Medical Services (EMS) field (defined as two years or less of EMS employment) through an analysis of 10 years of Longitudinal EMT Attributes and Demographic Study (LEADS) data. Data were obtained from 10 years of LEADS surveys (1999-2008). Individuals new to the profession were identified through responses to a survey item. Their responses were analyzed using weights reflecting each individual's probability of selection. Means, proportions, and 95% confidence intervals (CIs) were determined and used to identify statistically significant differences. There were few changes in the demographic characteristics of new EMT-Basics and Paramedics across survey years. New EMT-Basics tended to be older and less likely to have a college degree than new EMT-Paramedics. More new EMT-Basics than EMT-Paramedics worked in rural areas and small towns and reported that they were working as a volunteer. There were differences between new EMT-Basics and EMT-Paramedics in several of the reasons for entering the profession and in facets of job satisfaction. The findings provide guidance for recruiters, educators, employers, and governmental EMS policy organizations and will provide better insight into how to attract and retain new entrants to the field. Chapman SA , Crowe RP , Bentley MA . Recruitment and retention of new Emergency Medical Technician (EMT)-Basics and Paramedics. Prehosp Disaster Med. 2016;31(Suppl. 1):s70-s86.

Comprehensive Small Engine Repair.

ERIC Educational Resources Information Center

Hires, Bill; And Others

This curriculum guide contains the basic information needed to repair all two- and four-stroke cycle engines. The curriculum covers four areas, each consisting of one or more units of instruction that include performance objectives, suggested activities for teacher and students, information sheets, assignment sheets, job sheets, visual aids,…

The Relationship Between Willingness To Manipulate Others And Success In Two Different Types Of Basic Speech Communication

ERIC Educational Resources Information Center

Burgoon, Michael

1971-01-01

Through experimentation the author finds that there is a positive relationship between willingness to manipulate other people and success in a course where small group and dyadic communication activities compromise most of the performance experience. (Author/MS)

78 FR 12072 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... unwarranted invasion of personal privacy. Name of Committee: AIDS and Related Research Integrated Review Group... Emphasis Panel; PAR Panel: Cancer Health Disparities/Diversity in Basic Cancer Research. Date: March 18-19... for Scientific Review Special Emphasis Panel; Small Business: Orthopedic and Skeletal Biology. Date...

A Reference Unit on Home Vegetable Gardening.

ERIC Educational Resources Information Center

McCully, James S., Comp.; And Others

Designed to provide practical, up-to-date, basic information on home gardening for vocational agriculture students with only a limited knowledge of vegetable gardening, this reference unit includes step-by-step procedures for planning, planting, cultivating, harvesting, and processing vegetables in a small plot. Topics covered include plot…

Highway Maintenance Equipment Operator. Miscellaneous Equipment. Training Materials.

ERIC Educational Resources Information Center

Perky, Sandra Dutreau; And Others

This curriculum guide provides instructional materials to assist in training equipment operators in the safe and effective use of highway maintenance equipment. It includes six units of instruction covering the small, specialized equipment used in maintenance operations. Each unit of instruction consists of eight basic components: performance…

78 FR 71614 - Submission for OMB Review; MyUSA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-29

... change to http://www.regulations.gov , including any personal and/or business confidential information... information, and may include: Name, home address, phone number, date of birth, gender, marital status and basic demographic information such as whether the individual is married, a veteran, a small business...

Assessing MoDOT's efforts to provide the right transportation solution.

DOT National Transportation Integrated Search

2009-12-12

The basic research design for the project was to sample opinions on a variety of projects spread across the state. When available, a : small, medium, and large project from each of the ten MoDOT districts was selected by a regional manager for the pr...

Assessing MoDOT's efforts to provide the right transportation solution

DOT National Transportation Integrated Search

2009-03-01

The basic research design for the project was to sample opinions on a variety of projects spread across the state. When available, a : small, medium, and large project from each of the ten MoDOT districts was selected by a regional manager for the pr...

Assessing MoDOT's efforts to provide the right transportation solution.

DOT National Transportation Integrated Search

2014-12-01

The basic research design for the project was to sample opinions on a variety of projects spread : across the state. A small, medium, and large project from each of the seven MoDOT districts was : selected by a regional manager for the project for a ...

Assessing MoDOT's efforts to provide the right transportation solution.

DOT National Transportation Integrated Search

2015-12-01

The basic research design for the project was to sample opinions on a variety of projects spread : across the state. A small, medium, and large project from each of the seven MoDOT districts was : selected by a regional manager for the project for a ...

75 FR 9614 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-03

... manufacturer of the basic classes of controlled substances listed in schedule I: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I The company plans to manufacture small quantities of marihuana derivatives for research purposes. In reference to drug code 7360 (Marihuana), the company plans to bulk...

76 FR 21917 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... manufacturer of the following basic classes of controlled substances: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I The company plans to manufacture small quantities of marihuana derivatives for research purposes. In reference to drug code 7360 (Marihuana), the company plans to bulk manufacture cannabidiol. In...

75 FR 64744 - Manufacturer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... manufacturer of the basic classes of controlled substances listed in schedule I: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I The company plans to manufacture small quantities of marihuana derivatives for research purposes. In reference to drug code 7360 (Marihuana), the company plans to bulk...

Improving Learning in Rural Schools through Instructional Computing.

ERIC Educational Resources Information Center

Friedman, Daniel

Effective individualized learning continues to be the primary educational goal of small-rural schools. Three thrusts towards individualized learning--non-graded instruction, an emphasis on basic skills, and socially relevant education--can be enhanced by instructional computing, the use of microcomputers to facilitate learning. However, most…

Technological Effects on Interpersonal Communication: A Classroom Activity.

ERIC Educational Resources Information Center

Vandehaar, Debb

Noting that few scholars have examined specifically how technology is affecting basic communication processes, students in interpersonal, small group, and advanced presentational forms classes studied the systems model of interpersonal communication. The systems model described by P. Emmert and W.C. Donaghy includes the following components:…

Making Do with Less: Calibrating a True Travel Demand Model Without Traditional Survey Data

DOT National Transportation Integrated Search

1997-01-01

For many small and medium-sized cities, funding a full Home-Interview survey, with costs as high as $100 per household, is not feasible. Traditionally, such a survey has provided the basic foundation for developing a truly useful travel demand model....

Assessing MoDOT's efforts to provide the right transportation solution.

DOT National Transportation Integrated Search

2012-12-01

The basic research design for the project was to sample opinions on a variety of projects spread : across the state. A small, medium, and large project from each of the seven MoDOT districts was : selected by a regional manager for the project for a ...

Assessing MoDOT's efforts to provide the right transportation solution.

DOT National Transportation Integrated Search

2011-01-01

The basic research design for the project was to sample opinions on a variety of projects spread across the state. When available, a small, medium, and large project from each of the ten MoDOT districts was selected by a regional manager for the proj...

Assessing MoDOT's efforts to provide the right transportation solution

DOT National Transportation Integrated Search

2008-02-01

The basic research design for the project was to sample opinions on a variety of projects spread across the state. When available, a : small, medium, and large project from each of the ten MoDOT districts was selected by a regional manager for the pr...

Log sort yard economics, planning, and feasibility

Treesearch

John Rusty Dramm; Robert Govett; Ted Bilek; Gerry L. Jackson

2004-01-01

This publication discusses basic marketing and economic concepts, planning approach, and feasibility methodology for assessing log sort yard operations. Special attention is given to sorting small diameter and underutilized logs from forest restoration, fuels reduction, and thinning operations. A planned programming approach of objectively determining the feasibility...

Population education for young adults: making the small family desirable.

PubMed

Butt, H

1972-01-01

The approach to population control has been almost totally clinical in India so far. A new program of population education which is broader than the clinical appeal is needed. The major target population in India would be illiterates and those with a small amount of education. Within this target population different groups would have to be treated differently. Division would be between illiterates and literates, between urban and rural populations, and between male and female groups. Family planning must be related to other aspects of life, e.g., the health and well-being of the mother and other children in the family. Sex and social education must be presented together. Basic values cannot be changed. Smaller families will eventually change the values. By concentrating on the basic value of survival of the family, the best method to effect this can be shown to be better care of fewer c hildren rather than proliferation of many children. Education should concentrate on the individual and on economic reasons for limiting family size. Once the idea of limiting family size is accepted, it remains to be shown that methods for doing this are available, safe, and religiously and socially acceptable. The message needs constant repetition. Group education would be least expensive. Population education could be presented by incorporating it into other socioeconomic contexts such as reading classes for the illiterates and mathematics classes for the basic literates.

Structure and expression of a novel compact myelin protein – Small VCP-interacting protein (SVIP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Jiawen; Peng, Dungeng; Voehler, Markus

2013-10-11

Highlights: •SVIP (small p97/VCP-interacting protein) co-localizes with myelin basic protein (MBP) in compact myelin. •We determined that SVIP is an intrinsically disordered protein (IDP). •The helical content of SVIP increases dramatically during its interaction with negatively charged lipid membrane. •This study provides structural insight into interactions between SVIP and myelin membranes. -- Abstract: SVIP (small p97/VCP-interacting protein) was initially identified as one of many cofactors regulating the valosin containing protein (VCP), an AAA+ ATPase involved in endoplasmic-reticulum-associated protein degradation (ERAD). Our previous study showed that SVIP is expressed exclusively in the nervous system. In the present study, SVIP and VCPmore » were seen to be co-localized in neuronal cell bodies. Interestingly, we also observed that SVIP co-localizes with myelin basic protein (MBP) in compact myelin, where VCP was absent. Furthermore, using nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopic measurements, we determined that SVIP is an intrinsically disordered protein (IDP). However, upon binding to the surface of membranes containing a net negative charge, the helical content of SVIP increases dramatically. These findings provide structural insight into interactions between SVIP and myelin membranes.« less

On the future contents of a small journal of histochemistry.

PubMed

Pellicciari, C

2012-12-10

In the last three years, more than 70,000 scientific articles have been published in peer reviewed journals on the application of histochemistry in the biomedical field: most of them did not appear in strictly histochemical journals, but in others dealing with cell and molecular biology, medicine or biotechnology. This proves that histochemistry is still an active and innovative discipline with relevance in basic and applied biological research, but also demonstrates that especially the small histochemical Journals should likely reconsider their scopes and strategies to preserve their authorship. A review of the last three years volumes of the European Journal of Histochemistry, taken as an example of a long-time established small Journal, confirmed that the published articles were widely heterogeneous in their topics and experimental models, as in this Journal's tradition. This strongly suggests that a Journal of histochemistry should keep its role as a forum open to an audience as broad as possible, publishing papers on cell and tissue biology in a wide variety of models. This will improve knowledge of the basic mechanisms of development and differentiation, while helping to increase the number of potential authors since scientists who generally do not use histochemistry in their research will find hints for the applications of histochemical techniques to novel still unexplored subjects.

On the future contents of a small journal of histochemistry

PubMed Central

Pellicciari, C.

2012-01-01

In the last three years, more than 70,000 scientific articles have been published in peer reviewed journals on the application of histochemistry in the biomedical field: most of them did not appear in strictly histochemical journals, but in others dealing with cell and molecular biology, medicine or biotechnology. This proves that histochemistry is still an active and innovative discipline with relevance in basic and applied biological research, but also demonstrates that especially the small histochemical journals should likely reconsider their scopes and strategies to preserve their authorship. A review of the last three years volumes of the European Journal of Histochemistry, taken as an example of a long-time established small journal, confirmed that the published articles were widely heterogeneous in their topics and experimental models, as in this journal's tradition. This strongly suggests that a journal of histochemistry should keep its role as a forum open to an audience as broad as possible, publishing papers on cell and tissue biology in a wide variety of models. This will improve knowledge of the basic mechanisms of development and differentiation, while helping to increase the number of potential authors since scientists who generally do not use histochemistry in their research will find hints for the applications of histochemical techniques to novel still unexplored subjects. PMID:23361247

Vasculitic wheel - an algorithmic approach to cutaneous vasculitides.

PubMed

Ratzinger, Gudrun; Zelger, Bettina Gudrun; Carlson, J Andrew; Burgdorf, Walter; Zelger, Bernhard

2015-11-01

Previous classifications of vasculitides suffer from several defects. First, classifications may follow different principles including clinicopathologic findings, etiology, pathogenesis, prognosis, or therapeutic options. Second, authors fail to distinguish between vasculitis and coagulopathy. Third, vasculitides are systemic diseases. Organ-specific variations make morphologic findings difficult to compare. Fourth, subtle changes are recognized in the skin, but may be asymptomatic in other organs. Our aim was to use the skin and subcutis as a model and the clinicopathologic correlation as the basic process for classification. We use an algorithmic approach with pattern analysis, which allows for consistent reporting of microscopic findings. We first differentiate between small and medium vessel vasculitis. In the second step, we differentiate the subtypes of small (capillaries versus postcapillary venules) and medium-sized (arterioles/arteries versus veins) vessels. In the final step, we differentiate, according to the predominant cell type, into leukocytoclastic and/or granulomatous vasculitis. Starting from leukocytoclastic vasculitis as a central reaction pattern of cutaneous small/medium vessel vasculitides, its relations or variations may be arranged around it like spokes of a wheel around the hub. This may help establish some basic order in this rather complex realm of cutaneous vasculitides, leading to a better understanding in a complicated field. © 2015 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Streamflow variation of forest covered catchments

NASA Astrophysics Data System (ADS)

Gribovszki, Z.; Kalicz, P.; Kucsara, M.

2003-04-01

Rainfall concentration and runoff, otherwise rainfall-runoff processes, which cause river water discharge fluctuation, is one of the basic questions of hydrology. Several social-economy demands have a strong connection with small or bigger rivers from the point of view both quantity and quality of the water. Gratification or consideration of these demands is complicated substantially that we have still poor knowledge about our stream-flow regime. Water resources mainly stem from upper watersheds. These upper watersheds are the basis of the water concentration process; therefore we have to improve our knowledge about hydrological processes coming up in these territories. In this article we present runoff regime of two small catchments on the basis of one year data. Both catchments have a similar magnitude 0.6 and 0.9 km^2. We have been analyzed in detail some hydrological elements: features of rainfall, discharge, rainfall induced flooding waves and basic discharge in rainless periods. Variances of these parameters have been analyzed in relation to catchments surface, vegetation coverage and forest management. Result data set well enforce our knowledge about small catchments hydrological processes. On the basis of these fundamentals we can plan more established the management of these lands (forest practices, civil engineering works, and usage of natural water resources).

Aerospace manpower transfer to small business enterprises

NASA Technical Reports Server (NTRS)

Green, M. K.

1972-01-01

The feasibility of a program to effect transfer of aerospace professional people from the ranks of the unemployed into gainful employment in the small business community was investigated. The effectiveness of accomplishing transfer of technology from the aerospace effort into the private sector through migration of people rather than products or hardware alone was also studied. Two basic methodologies were developed. One involves the matching of ex-aerospace professionals and small companies according to their mutual needs. A training and indoctrination program is aimed at familiarizing the professional with the small company environment, and a program of follow-up counseling is defined. The second methodology incorporates efforts to inform and arouse interest among the nonaerospace business community toward affirmative action programs that will serve mutual self-interests of the individuals, companies, and communities involved.

A polyvalent harmonic coil testing method for small-aperture magnets

NASA Astrophysics Data System (ADS)

Arpaia, Pasquale; Buzio, Marco; Golluccio, Giancarlo; Walckiers, Louis

2012-08-01

A method to characterize permanent and fast-pulsed iron-dominated magnets with small apertures is presented. The harmonic coil measurement technique is enhanced specifically for small-aperture magnets by (1) in situ calibration, for facing search-coil production inaccuracy, (2) rotating the magnet around its axis, for correcting systematic effects, and (3) measuring magnetic fluxes by stationary coils at different angular positions for measuring fast pulsed magnets. This method allows a quadrupole magnet for particle accelerators to be characterized completely, by assessing multipole field components, magnetic axis position, and field direction. In this paper, initially the metrological problems arising from testing small-aperture magnets are highlighted. Then, the basic ideas of the proposed method and the architecture of the corresponding measurement system are illustrated. Finally, experimental validation results are shown for small-aperture permanent and fast-ramped quadrupole magnets for the new linear accelerator Linac4 at CERN (European Organization for Nuclear Research).

An experimental study of potential residential and commercial applications of small-scale hybrid power systems

NASA Astrophysics Data System (ADS)

Acosta, Michael Anthony

The research presented in this thesis provides an understanding of small-scale hybrid power systems. Experiments were conducted to identify potential applications of renewable energy in residential and commercial applications in the Rio Grande Valley of Texas. Solar and wind energy converted into electric energy was stored in batteries and inverted to power common household and commercial appliances. Several small to medium size hybrid power systems were setup and utilized to conduct numerous tests to study renewable energy prospects and feasibility for various applications. The experimental results obtained indicate that carefully constructed solar power systems can provide people living in isolated communities with sufficient energy to consistently meet their basic power needs.

A sparse matrix algorithm on the Boolean vector machine

NASA Technical Reports Server (NTRS)

Wagner, Robert A.; Patrick, Merrell L.

1988-01-01

VLSI technology is being used to implement a prototype Boolean Vector Machine (BVM), which is a large network of very small processors with equally small memories that operate in SIMD mode; these use bit-serial arithmetic, and communicate via cube-connected cycles network. The BVM's bit-serial arithmetic and the small memories of individual processors are noted to compromise the system's effectiveness in large numerical problem applications. Attention is presently given to the implementation of a basic matrix-vector iteration algorithm for space matrices of the BVM, in order to generate over 1 billion useful floating-point operations/sec for this iteration algorithm. The algorithm is expressed in a novel language designated 'BVM'.

Vygotsky's Zone of Proximal Development as a Theoretical Foundation for Cooperative Learning.

ERIC Educational Resources Information Center

Doolittle, Peter E.

1997-01-01

Discusses integration of Lev Vygotsky's theory of the Zone of Proximal Development (ZPD) with the instructional strategy of cooperative learning. ZPD provides a conceptual basis for explaining the five basic tenets of cooperative learning: positive interdependence; face-to-face interaction; individual accountability; small-group and interpersonal…

Educational Exceptionalism in Small (and Micro) States: Cooperative Educational Transfer and TVET

ERIC Educational Resources Information Center

Jules, Tavis D.

2015-01-01

Since 2002, the 15 member states of the Caribbean Community (CARICOM) have shifted human resource development reforms from focusing on providing basic, mass primary and secondary education and limited tertiary education toward diverting resources to "Technical and Vocational Education and Training" (TVET) to accommodate labor mobility.…

Leadership for Differentiating Schools & Classrooms.

ERIC Educational Resources Information Center

Tomlinson, Carol Ann; Allan, Susan Demirsky

Differentiation is simply a teacher attending to the learning needs of a particular student or small group of students, rather than teaching a class as though all individuals in it were basically alike. This book explores in 10 chapters how school leaders can develop responsive, personalized, and differentiated classrooms: (1) "Understanding…

Outdoor Activities for Environmental Studies.

ERIC Educational Resources Information Center

Knapp, Clifford E.

This booklet is a compilation of field-tested outdoor activities introducing basic projects for small group or individualized study in monitoring certain aspects of the environment. Its purpose is to provide teachers with new ways to involve children directly in meaningful and developmental learning activities and to help students become more…

Geospatial application of the Water Erosion Prediction Project (WEPP) model

USDA-ARS?s Scientific Manuscript database

At the hillslope profile and/or field scale, a simple Windows graphical user interface (GUI) is available to easily specify the slope, soil, and management inputs for application of the USDA Water Erosion Prediction Project (WEPP) model. Likewise, basic small watershed configurations of a few hillsl...

Estimating Solar Proton Flux at LEO From a Geomagnetic Cutoff Model

DTIC Science & Technology

2015-07-14

simple shadow cones (using nomenclature from Stormer theory of particle motion in a dipole magnetic field [6]), that result from particles trajectories...basic Stormer theory [7]. However, in LEO the changes would be small relative to uncertainties in the model and therefore unnecessary. If the model were

Protecting Creeksheds: Analysis and Action.

ERIC Educational Resources Information Center

Say, E. Wayne; Dines, Allen J.

This booklet is designed to provide basic information about creeksheds in urbanizing areas; why they are important, how they are adversely affected by urbanization and what can be done to protect creek benefits and avoid problems. The text provides non-technical information relating to small watersheds and their management. The booklet is designed…

Handbook of Reference Sources. Third Edition.

ERIC Educational Resources Information Center

Nichols, Margaret Irby

This third edition of popular and useful reference works, which emphasizes the needs of small libraries, contains 975 annotated entries and lists 201 additional titles (most with bibliographic and order information) in the annotations, representing an expansion of 30 percent over the second edition. The appendix lists 116 basic or core reference…

Protective interior wall and attaching means for a fusion reactor vacuum vessel

DOEpatents

Phelps, R.D.; Upham, G.A.; Anderson, P.M.

1985-03-01

The wall basically consists of an array of small rectangular plates attached to the existing walls with threaded fasteners. The protective wall effectively conceals and protects all mounting hardware beneath the plate array, while providing a substantial surface area that will absorb plasma energy.

Tag Team Public Speaking

ERIC Educational Resources Information Center

Brigance, Linda Czuba

2004-01-01

Designing and presenting a speech is a solitary task. By definition, public speaking involves one person speaking to a group, which sets it apart from other types of communication situations, such as interpersonal and small group communication. Due to the inherently individualistic nature of assignments in the basic course, students rarely profit…

Selling to NASA

NASA Technical Reports Server (NTRS)

1981-01-01

The prospective NASA contractor is provided with information that describes the agency and its procurement practices. Products include ideas, manufacturing capabilities, fabricated components, construction, basic materials, and specialized services. NASA assistance in marketing these and other products is emphasized. Small and minority business enterprises are discussed. The agency's scientific and technical information activities are also discussed.

The next generation of training for Arabidopsis researchers: bioinformatics and quantitative biology

USDA-ARS?s Scientific Manuscript database

It has been more than 50 years since Arabidopsis (Arabidopsis thaliana) was first introduced as a model organism to understand basic processes in plant biology. A well-organized scientific community has used this small reference plant species to make numerous fundamental plant biology discoveries (P...

Economic Literacy: An Instructional Guide for Vocational Education.

ERIC Educational Resources Information Center

Blackman, Linda L.; And Others

This instructor's guide consists of materials for use in helping vocational education students acquire basic economic literacy. Addressed in the individual units of the guide are the following topics: worker productivity, the free enterprise system, components of the economy, the consumer as a decision maker, small business functions, economic…

Interminable Knots: Hostages to Toxic Stories

ERIC Educational Resources Information Center

Sagan, Olivia

2011-01-01

This paper presents one case study from a five-year psychosocial exploration of the auto/biographic activity of a small group of mental health service users. Each individual voluntarily took part in a weekly basic expressive literacy course in which they were encouraged to improve their writing skills. Biographic narrative interviews which…

78 FR 49547 - Manufacturer of Controlled Substances; Notice of Registration; American Radiolabeled Chemicals, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

... manufacture small quantities of the listed controlled substances as radiolabeled compounds for biochemical... the listed basic classes of controlled substances is consistent with the public interest at this time... is consistent with the public interest. The investigation has included inspection and testing of the...

Guiding Students to Interpret a Novel.

ERIC Educational Resources Information Center

Au, Kathryn H.; Scheu, Judith A.

1989-01-01

Describes four lessons for "Sadako and the Thousand Paper Cranes" by Eleanor Coerr, developed by teachers in the Kamehameha Elementary Education Program (KEEP), Hawaii. Observes the links between the two basic activities, reading journals and small group discussions, as well as students' growth in thinking about and responding to the…

Disturbance regimes and their relationships to forest health.

Treesearch

Brian W. Geils; John E. Lundquist; Jose F. Negron; Jerome S. Beatty

1995-01-01

While planners deal with landscape issues in forest health, silviculturists deal with the basic units of the landscape, forest stands. The silviculturist manipulates small-scale disturbances and needs appropriate management indicators. Disturbance agents and their effects are important to stand development and are therefore useful as management indicators. More studies...

76 FR 39127 - Manufacturer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... Administration (DEA) to be registered as a bulk manufacturer of Remifentanil (9739) the basic class of controlled substance in schedule II. The company plans to utilize this facility to manufacture small quantities of the... primary manufacturing facility in West Deptford, New Jersey. The controlled substances manufactured in...

77 FR 5849 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... (DEA) to be registered as a bulk manufacturer of Remifentanil (9739), the basic class of controlled substance in schedule II. The company plans to utilize this facility to manufacture small quantities of the... manufacturing facility in West Deptford, New Jersey. The controlled substances manufactured in bulk at this...

40 CFR 60.1665 - What information must I include in the plant-specific operating manual?

Code of Federal Regulations, 2010 CFR

2010-07-01

... startup, shutdown, and malfunction of the municipal waste combustion unit. (e) Procedures for maintaining... Emission Guidelines and Compliance Times for Small Municipal Waste Combustion Units Constructed on or... the basic combustion principles that apply to municipal waste combustion units. (c) Procedures for...

40 CFR 62.15120 - What information must I include in the plant-specific operating manual?

Code of Federal Regulations, 2013 CFR

2013-07-01

... startup, shutdown, and malfunction of the municipal waste combustion unit. (e) Procedures for maintaining... DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements for Small Municipal Waste Combustion Units... the basic combustion principles that apply to municipal waste combustion units. (c) Procedures for...

Casco Bay Partnership for Workplace Education. Final Performance Report.

ERIC Educational Resources Information Center

University of Southern Maine, Gorham.

The Casco Bay Partnership includes the University of Southern Maine (USM) and seven businesses in greater Portland, Maine, that range from large multinational corporations to small, family-owned businesses. During a 3-year project funded by a National Workplace Literacy Program grant, the partnership designed and delivered workplace basic skills…

Native Teacher Education in a Community Setting: The Mt. Currie Program

ERIC Educational Resources Information Center

Wyatt, June

1977-01-01

Describes the Mt. Currie Native Teacher Education Program, based in a small reserve community 100 miles from Vancouver, Canada. Five basic issues involved in the development of the program are community involvement at the local level, incorporation of native language and culture, decentralization, entrance requirements and paraprofessional…

Certified records manager exam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-01-01

The Institute of Certified Records Managers (ICRM) is a non-profit, certifying organization of professional records managers and administrators. ICRM members are experienced in information requirements, records and information systems, and the related office systems and technologies. All members have met certification requirements and have received the Certified Records Manager (CRM) designation. As the field of information and records management moves toward standardization, and as the application of new technologies and technicalities complicate the measurement and demonstration of professional competence, the need for a means of identifying persons who have basic competency increases. The ICRM is providing such a means bymore » testing and certifying basic knowledge. More and more job announcements are requiring this evidence of competency. Unfortunately, as an organization, NIRMA has a relatively small number of CRMs. The goal of the ICRM Development Group is two-fold; (1) to encourage NIRMA members to obtain their certification by providing basic information and support and; (2) to develop the Nuclear Specialist test module which will demonstrate that bearers have demonstrated expertise in nuclear records management as well as basic competencies. This report covers the examination process.« less

Structure and expression of the attacin genes in Hyalophora cecropia.

PubMed

Sun, S C; Lindström, I; Lee, J Y; Faye, I

1991-02-26

To study the regulation of the immune genes in insects, we have cloned and sequenced the attacin gene locus of the giant silk moth Hyalophora cecropia. The locus contains one acidic and one basic attacin gene as well as two pseudogenes, which are remnants of basic attacin genes. A small insertion element was found within the locus. The two functional attacin genes are transcribed in opposite directions and have two introns inserted at homologous positions. A common sequence, GGGGATTCCT, is found at nucleotide position -48 in the acidic gene and at nucleotide position -58 in the basic gene. Interestingly, this decanucleotide is similar to the consensus of the NF-k B-binding site. Expression studies revealed that both attacins are strongly induced by phorbol 12-myristate 13-acetate, lipopolysaccharide and bacteria. However, only the acidic attacin gene showed a clear response to injury.

The Goertler vortex instability mechanism in three-dimensional boundary layers

NASA Technical Reports Server (NTRS)

Hall, P.

1984-01-01

The two dimensional boundary layer on a concave wall is centrifugally unstable with respect to vortices aligned with the basic flow for sufficiently high values of the Goertler number. However, in most situations of practical interest the basic flow is three dimensional and previous theoretical investigations do not apply. The linear stability of the flow over an infinitely long swept wall of variable curvature is considered. If there is no pressure gradient in the boundary layer the instability problem can always be related to an equivalent two dimensional calculation. However, in general, this is not the case and even for small values of the crossflow velocity field dramatic differences between the two and three dimensional problems emerge. When the size of the crossflow is further increased, the vortices in the neutral location have their axes locally perpendicular to the vortex lines of the basic flow.

Understanding the Magic of the Bicycle; Basic scientific explanations to the two-wheeler's mysterious and fascinating behavior

NASA Astrophysics Data System (ADS)

Connolly, Joseph W.

The bicycle is a common, yet unique mechanical contraption in our world. In spite of this, the bike's physical and mechanical principles are understood by a select few. You do not have to be a genius to join this small group of people who understand the physics of cycling. This is your guide to fundamental principles (such as Newton's laws) and the book provides intuitive, basic explanations for the bicycle's behaviour. Each concept is introduced and illustrated with simple, everyday examples. Although cycling is viewed by most as a fun activity, and almost everyone acquires the basic skills at a young age, few understand the laws of nature that give magic to the ride. This is a closer look at some of these fun, exhilarating, and magical aspects of cycling. In the reading, you will also understand other physical principles such as motion, force, energy, power, heat, and temperature.

Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology.

PubMed

Schultz, Wolfram

2004-04-01

Neurons in a small number of brain structures detect rewards and reward-predicting stimuli and are active during the expectation of predictable food and liquid rewards. These neurons code the reward information according to basic terms of various behavioural theories that seek to explain reward-directed learning, approach behaviour and decision-making. The involved brain structures include groups of dopamine neurons, the striatum including the nucleus accumbens, the orbitofrontal cortex and the amygdala. The reward information is fed to brain structures involved in decision-making and organisation of behaviour, such as the dorsolateral prefrontal cortex and possibly the parietal cortex. The neural coding of basic reward terms derived from formal theories puts the neurophysiological investigation of reward mechanisms on firm conceptual grounds and provides neural correlates for the function of rewards in learning, approach behaviour and decision-making.

The Equations of Oceanic Motions

NASA Astrophysics Data System (ADS)

Müller, Peter

2006-10-01

Modeling and prediction of oceanographic phenomena and climate is based on the integration of dynamic equations. The Equations of Oceanic Motions derives and systematically classifies the most common dynamic equations used in physical oceanography, from large scale thermohaline circulations to those governing small scale motions and turbulence. After establishing the basic dynamical equations that describe all oceanic motions, M|ller then derives approximate equations, emphasizing the assumptions made and physical processes eliminated. He distinguishes between geometric, thermodynamic and dynamic approximations and between the acoustic, gravity, vortical and temperature-salinity modes of motion. Basic concepts and formulae of equilibrium thermodynamics, vector and tensor calculus, curvilinear coordinate systems, and the kinematics of fluid motion and wave propagation are covered in appendices. Providing the basic theoretical background for graduate students and researchers of physical oceanography and climate science, this book will serve as both a comprehensive text and an essential reference.

PREPARATION OF DIBASIC ALUMINUM NITRATE

DOEpatents

Gresky, A.T.; Nurmi, E.O.; Foster, D.L.; Wischow, R.P.; Savolainen, J.E.

1960-04-01

A method is given for the preparation and recovery of basic aluminum nltrates having an OH: Al ratio of at least two, comprising two steps. First, metallic aluminum is dissolved in aqueous Al(NO/sub 3/)/sub 3/, in the presence of a small quantity of elemental or ionic mercury, to increase its Al: NO/sub 3/ ratio into the range 1 to 1.2. The resulting aqueous solution is then added to an excess of a special organic solvent, typically a mixture of five parts methanol and six parts diethyl ether, whereupon the basic aluminum nitrate, e.g. Al/sub 6/(OH)/sub 13/-(NO/sub 3/)/sub 5/, recoverably precipitates.

LLL 8080 BASIC-II interpreter user's manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGoldrick, P.R.; Dickinson, J.; Allison, T.G.

1978-04-03

Scientists are finding increased applications for microprocessors as process controllers in their experiments. However, while microprocessors are small and inexpensive, they are difficult to program in machine or assembly language. A high-level language is needed to enable scientists to develop their own microcomputer programs for their experiments on location. Recognizing this need, LLL contracted to have such a language developed. This report describes the resulting LLL BASIC interpreter, which opeates with LLL's 8080-based MCS-8 microcomputer system. All numerical operations are done using Advanced Micro Device's Am9511 arithmetic processor chip or optionally by using a software simulation of that chip. 1more » figure.« less

Acculturation, personality, and psychological adjustment.

PubMed

Ahadi, Stephan A; Puente-Díaz, Rogelio

2011-12-01

Two studies investigated relationships between traditional indicators of acculturation, cultural distance, acculturation strategies, and basic dimensions of personality as they pertain to psychological adjustment among Hispanic students. Although personality characteristics have been shown to be important determinants of psychological well-being, acculturation research has put less emphasis on the role of personality in the well-being of immigrants. Hierarchical regression analysis showed that basic dimensions of personality such as extraversion and neuroticism were strongly related to psychological adjustment. Acculturation strategies did not mediate the effect of personality variables, but cultural resistance made a small, independent contribution to the explanation of some aspects of negative psychological adjustment. The implications of the results were discussed.

Biomechanical concepts applicable to minimally invasive fracture repair in small animals.

PubMed

Chao, Peini; Lewis, Daniel D; Kowaleski, Michael P; Pozzi, Antonio

2012-09-01

Understanding the basic biomechanical principles of surgical stabilization of fractures is essential for developing an appropriate preoperative plan as well as making prudent intraoperative decisions. This article aims to provide basic biomechanical knowledge essential to the understanding of the complex interaction between the mechanics and biology of fracture healing. The type of healing and the outcome can be influenced by several mechanical factors, which depend on the interaction between bone and implant. The surgeon should understand the mechanical principles of fracture fixation and be able to choose the best type of fixation for each specific fracture. Copyright © 2012 Elsevier Inc. All rights reserved.

Mass action at the single-molecule level.

PubMed

Shon, Min Ju; Cohen, Adam E

2012-09-05

We developed a system to reversibly encapsulate small numbers of molecules in an array of nanofabricated "dimples". This system enables highly parallel, long-term, and attachment-free studies of molecular dynamics via single-molecule fluorescence. In studies of bimolecular reactions of small numbers of confined molecules, we see phenomena that, while expected from basic statistical mechanics, are not observed in bulk chemistry. Statistical fluctuations in the occupancy of sealed reaction chambers lead to steady-state fluctuations in reaction equilibria and rates. These phenomena are likely to be important whenever reactions happen in confined geometries.

Small-angle scattering from 3D Sierpinski tetrahedron generated using chaos game

NASA Astrophysics Data System (ADS)

Slyamov, Azat

2017-12-01

We approximate a three dimensional version of deterministic Sierpinski gasket (SG), also known as Sierpinski tetrahedron (ST), by using the chaos game representation (CGR). Structural properties of the fractal, generated by both deterministic and CGR algorithms are determined using small-angle scattering (SAS) technique. We calculate the corresponding monodisperse structure factor of ST, using an optimized Debye formula. We show that scattering from CGR of ST recovers basic fractal properties, such as fractal dimension, iteration number, scaling factor, overall size of the system and the number of units composing the fractal.

Tapping rocks for Terror Lake hydro project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sieber, O.V.

The Terror Lake hydro project in Alaska is described. Terror Lake is a small alpine lake surrounded by barren glacier-scoured, rocky mountain tops and plateaus that do not retain moisture. The method for obtaining more water for the hydro project in Kodiak is unique. The basic program was to dam up the outlet of Terror Lake and raise the water level 170 ft. from approximately 1250 ft. above sea level to 1420 ft. Although the megawatt output of the project is small, the concept of the Terror Lake Project has an epic scale to it.

Effects of urbanization on the magnitude and frequency of floods on small streams in Tennessee; basic data report no. 2

USGS Publications Warehouse

Robbins, Clarence H.

1982-01-01

Peak stages, discharges, and rainfall recorded at 22 gaging stations on streams draining small (less than 25 mi super 2) urbanized basins across Tennessee are presented. The gaged basins are in 17 different municipalities with populations ranging between 5,000 and 100,000. The report gives a description of each gaged site along with a data sheet on which peak stages, discharges, and corresponding rainfall are listed. The description gives the station location, type of gage, basin characteristics, and general remarks. (USGS)

An Expected Value Air Combat Model Simulation Algorithm to Predict Missions Performance in Tactical Air Operations.

DTIC Science & Technology

1983-09-01

Approved by: Me<i W4 1tsZ7 CaifI ,KDpartmento I inistrative Science 3 ( ABSTRACT >This thesis intends to create the basic...a need for a small scale model which allows a student analyst of tactical air operations to create his own battles and to test his own strategies with...iconic model is a large or small-scale repre- sentation of states-objects, or events. For example a scale model airplance resembles the system under the

Effects of turbulence on mixed-phase deep convective clouds under different basic-state winds and aerosol concentrations

NASA Astrophysics Data System (ADS)

Lee, Hyunho; Baik, Jong-Jin; Han, Ji-Young

2014-12-01

The effects of turbulence-induced collision enhancement (TICE) on mixed-phase deep convective clouds are numerically investigated using a 2-D cloud model with bin microphysics for uniform and sheared basic-state wind profiles and different aerosol concentrations. Graupel particles account for the most of the cloud mass in all simulation cases. In the uniform basic-state wind cases, graupel particles with moderate sizes account for some of the total graupel mass in the cases with TICE, whereas graupel particles with large sizes account for almost all the total graupel mass in the cases without TICE. This is because the growth of ice crystals into small graupel particles is enhanced due to TICE. The changes in the size distributions of graupel particles due to TICE result in a decrease in the mass-averaged mean terminal velocity of graupel particles. Therefore, the downward flux of graupel mass, and thus the melting of graupel particles, is reduced due to TICE, leading to a decrease in the amount of surface precipitation. Moreover, under the low aerosol concentration, TICE increases the sublimation of ice particles, consequently playing a partial role in reducing the amount of surface precipitation. The effects of TICE are less pronounced in the sheared basic-state wind cases than in the uniform basic-state wind cases because the number of ice crystals is much smaller in the sheared basic-state wind cases than in the uniform basic-state wind cases. Thus, the size distributions of graupel particles in the cases with and without TICE show little difference.

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

NASA Astrophysics Data System (ADS)

Zemlyanaya, E. V.; Kiselev, M. A.; Zhabitskaya, E. I.; Aksenov, V. L.; Ipatova, O. M.; Ivankov, O. I.

2018-05-01

The small-angle neutron scattering technique (SANS) is employed for investigation of structure of the phospholipid transport nanosystem (PTNS) elaborated in the V.N.Orekhovich Institute of Biomedical Chemistry (Moscow, Russia). The SANS spectra have been measured at the YuMO small-angle spectrometer of IBR-2 reactor (Joint Institute of Nuclear Research, Dubna, Russia). Basic characteristics of polydispersed population of PTNS unilamellar vesicles (average radius of vesicles, polydispersity, thickness of membrane, etc.) have been determined in three cases of the PTNS concentrations in D2O: 5%, 10%, and 25%. Numerical analysis is based on the separated form factors method (SFF). The results are discussed in comparison with the results of analysis of the small-angle X-ray scattering spectra collected at the Kurchatov Synchrotron Radiation Source of the National Research Center “Kurchatov Institute” (Moscow, Russia).

High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

NASA Astrophysics Data System (ADS)

Larsson, Daniel H.; Vågberg, William; Yaroshenko, Andre; Yildirim, Ali Önder; Hertz, Hans M.

2016-12-01

X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-power small-spot liquid-metal-jet electron-impact source. The tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.

Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy

PubMed Central

2014-01-01

Background Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular dystrophy (DMD), which remains incurable. Substitution of muscle by fibrotic tissue also complicates gene/cell therapies for DMD. Yet, no optimal models to study muscle fibrosis are available. In the widely used mdx mouse model for DMD, extensive fibrosis develops in the diaphragm only at advanced adulthood, and at about two years of age in the ‘easy-to-access’ limb muscles, thus precluding fibrosis research and the testing of novel therapies. Methods We developed distinct experimental strategies, ranging from chronic exercise to increasing muscle damage on limb muscles of young mdx mice, by myotoxin injection, surgically induced trauma (laceration or denervation) or intramuscular delivery of profibrotic growth factors (such as TGFβ). We also extended these approaches to muscle of normal non-dystrophic mice. Results These strategies resulted in advanced and enhanced muscle fibrosis in young mdx mice, which persisted over time, and correlated with reduced muscle force, thus mimicking the severe DMD phenotype. Furthermore, increased fibrosis was also obtained by combining these procedures in muscles of normal mice, mirroring aberrant repair after severe trauma. Conclusions We have developed new and improved experimental strategies to accelerate and enhance muscle fibrosis in vivo. These strategies will allow rapidly assessing fibrosis in the easily accessible limb muscles of young mdx mice, without necessarily having to use old animals. The extension of these fibrogenic regimes to the muscle of non-dystrophic wild-type mice will allow fibrosis assessment in a wide array of pre-existing transgenic mouse lines, which in turn will facilitate understanding the mechanisms of fibrogenesis. These strategies should improve our ability to combat fibrosis-driven dystrophy progression and aberrant regeneration. PMID:25157321

Sharing a Personal Trainer: Personal and Social Benefits of Individualized, Small-Group Training.

PubMed

Wayment, Heidi A; McDonald, Rachael L

2017-11-01

Wayment, HA and McDonald, RL. Sharing a personal trainer: personal and social benefits of individualized, small-group training. J Strength Cond Res 31(11): 3137-3145, 2017-We examined a novel personal fitness training program that combines personal training principles in a small-group training environment. In a typical training session, exercisers warm-up together but receive individualized training for 50 minutes with 1-5 other adults who range in age, exercise experience, and goals for participation. Study participants were 98 regularly exercising adult members of a fitness studio in the southwestern United States (64 women and 32 men), aged 19-78 years (mean, 46.52 years; SD = 14.15). Average membership time was 2 years (range, 1-75 months; mean, 23.54 months; SD = 20.10). In collaboration with the program directors, we developed a scale to assess satisfaction with key features of this unique training program. Participants completed an online survey in Fall 2015. Hypotheses were tested with a serial mediator model (model 6) using the SPSS PROCESS module. In support of the basic tenets of self-determination theory, satisfaction with small-group, individualized training supported basic psychological needs, which in turn were associated with greater autonomous exercise motivation and life satisfaction. Satisfaction with this unique training method was also associated with greater exercise self-efficacy. Autonomous exercise motivation was associated with both exercise self-efficacy and greater self-reported health and energy. Discussion focuses on why exercise programs that foster a sense of social belonging (in addition to motivation and efficacy) may be helpful for successful adherence to an exercise program.

76 FR 69044 - HUD Debt Collection: Revisions and Update to the Procedures for the Collection of Claims

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

...' Group Life Insurance and ``Basic Life'' Federal Employees' Group Life Insurance premiums are considered to be normal life insurance premiums; all optional Federal Employees' Group Life Insurance premiums... employees. The revisions impose no significant economic impact on a substantial number of small entities...

The Whole Library Handbook 3: Current Data, Professional Advice, and Curiosa about Libraries and Library Services.

ERIC Educational Resources Information Center

Eberhart, George M., Comp.

This handbook contains articles, guidelines, and other information from the field of library science organized into the following chapters: (1) "Libraries," including some basic figures, academic libraries, public libraries, school libraries, special libraries, national libraries, state libraries, small libraries, facilities, the past, and the…

Facts about Alcohol and Other Drug Use during Pregnancy. ARC Facts.

ERIC Educational Resources Information Center

Association for Retarded Citizens, Arlington, TX.

The fact sheet provides basic information about how alcohol and drug use during pregnancy can lead to Fetal Alcohol Syndrome (FAS) and Alcohol Related Birth Defects (ARBD), resulting in such problems as mental retardation, sleep disturbances, learning disabilities, muscle problems, heart defects, and small head size. The question and answer format…

Configuration-Control Scheme Copes With Singularities

NASA Technical Reports Server (NTRS)

Seraji, Homayoun; Colbaugh, Richard D.

1993-01-01

Improved configuration-control scheme for robotic manipulator having redundant degrees of freedom suppresses large joint velocities near singularities, at expense of small trajectory errors. Provides means to enforce order of priority of tasks assigned to robot. Basic concept of configuration control of redundant robot described in "Increasing The Dexterity Of Redundant Robots" (NPO-17801).

Disaster Day! Integrating Speech Skills though Impromptu Group Research and Presentation

ERIC Educational Resources Information Center

Pruim, Douglas E.

2016-01-01

Courses: Disaster Day (DD) is a single-class activity designed for public speaking classrooms, but could also be applied to courses addressing small group communication. Objectives: DD integrates fundamental skills of the basic speech course, fosters participation through group work, and introduces new concepts and skills. By the end of the…

42 CFR 417.104 - Payment for basic health services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... must be equivalent for all individuals in the same group and for all families of similar composition in...: (A) Individual (non-group) subscribers (including their families). (B) Small groups of subscribers... group basis as described in paragraph (b)(2) of this section. An HMO may fix its rates of payment under...

42 CFR 417.104 - Payment for basic health services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... must be equivalent for all individuals in the same group and for all families of similar composition in...: (A) Individual (non-group) subscribers (including their families). (B) Small groups of subscribers... group basis as described in paragraph (b)(2) of this section. An HMO may fix its rates of payment under...

Strategic Leadership Issues for the Community College Involving Technology Transfer in a Global Economy.

ERIC Educational Resources Information Center

Stewart, James C.; And Others

1990-01-01

Summarizes recent developments in Virginia designed to improve the productivity of the state's small and medium businesses by increased use of the state's postsecondary education institutions. Suggests that a strategy of comprehensive leadership by educators and politicians is basic to successful technology transfer programs in the context of a…

The Heart of School

ERIC Educational Resources Information Center

DiMartino, Joseph; Clarke, John H.

2008-01-01

Successful advisory programs have a number of things in common across a wide variety of schools. They all divide the student body into small groups, usually of 20 or fewer students, that meet regularly with an adult in the school community. In addition to this basic element, successful advisory programs have five other elements in common: (1) They…

The Future of Pathology: A Delphi Study by Pathology Department Chairmen

ERIC Educational Resources Information Center

Goodale, Fairfield; Gander, George W.

1976-01-01

Over 100 department chairmen in American and Canadian medical schools participated in this questionnaire study. Most are deeply concerned about increasing federal regulation of medicine, expect more emphasis on the basic science aspects of pathology, and foresee a shift of residency training programs away from small hospitals to larger medical…

Wisconsin Library Trustee Reference Manual.

ERIC Educational Resources Information Center

Opinion Research Corp., Princeton, NJ.

This newly updated and revised expansion of the Wisconsin Library Trustee's Manual serves as a comprehensive resource and how-to guide for board members of public libraries that range in size and scope from small to large communities in both urban and rural areas. The manual includes basic information to which every Wisconsin library trustee…

Basic Skills and Job Retention. Final Report.

ERIC Educational Resources Information Center

Seminole Community Coll., Sanford, FL.

A project developed an educational model to deliver academic remediation services to small businesses at a cost-effective rate by using a lead instructor and volunteer assistants. The first step was planning and implementing the tutor training segment. The class and accompanying manual were developed, and tutors were identified and trained in a…

The Greyhound Strike: Using a Labor Dispute to Teach Descriptive Statistics.

ERIC Educational Resources Information Center

Shatz, Mark A.

1985-01-01

A simulation exercise of a labor-management dispute is used to teach psychology students some of the basics of descriptive statistics. Using comparable data sets generated by the instructor, students work in small groups to develop a statistical presentation that supports their particular position in the dispute. (Author/RM)

10 CFR 431.445 - Determination of small electric motor efficiency.

Code of Federal Regulations, 2010 CFR

2010-01-01

... determined either by testing in accordance with § 431.444 of this subpart, or by application of an... method. An AEDM applied to a basic model must be: (i) Derived from a mathematical model that represents... statistical analysis, computer simulation or modeling, or other analytic evaluation of performance data. (3...

Modeling Human Performance in Restless Bandits with Particle Filters

ERIC Educational Resources Information Center

Yi, Sheng Kung M.; Steyvers, Mark; Lee, Michael

2009-01-01

Bandit problems provide an interesting and widely-used setting for the study of sequential decision-making. In their most basic form, bandit problems require people to choose repeatedly between a small number of alternatives, each of which has an unknown rate of providing reward. We investigate restless bandit problems, where the distributions of…

Zoo and Wildlife Libraries: An International Survey

ERIC Educational Resources Information Center

Coates, Linda L.; Tierney, Kaitlyn Rose

2010-01-01

The conservation and well-being of exotic animals is core to the mission of zoos, aquariums and many small nonprofit wildlife groups. Increasingly, these organizations are committed to scientific research, both basic and applied. To ascertain the current state of the libraries that support their efforts, librarians at the San Diego Zoo conducted…

Bridging Authentic Experiences and Literacy Skills through the Language Experience Approach

ERIC Educational Resources Information Center

Huang, Jiuhan

2013-01-01

Although the research base is small on adult English language learners (ELLs) who are learning English while also acquiring basic literacy, this research can still guide instructional practices. The essential components of reading skills suggests that the Language Experience Approach has the potential to integrate relevant meaning-focused reading…

[Project EXCEL. Curriculum for Casa Sanchez, Inc.: Modules 1-6.

ERIC Educational Resources Information Center

Career Resources Development Center, Inc., San Francisco, CA.

Six curriculum modules for Casa Sanchez, a San Francisco Mexican restaurant and food product manufacturer, are presented. Casa Sanchez was one of four small businesses involved in Project EXCEL, a workplace literacy project that focused on literacy and basic skills training for limited English proficient (LEP) workers. The modules are as follows:…

National Science Foundation FY 2004 Performance and Accountability Report.

ERIC Educational Resources Information Center

National Science Foundation, 2004

2004-01-01

The information provided in this report documents that the National Science Foundation (NSF) is a well-managed and effective organization with an outstanding staff dedicated to ensuring that America's future is secure and prosperous. Despite its small size, NSF is widely recognized as the catalyst for the advancement of basic research in America.…

The Effect of Variant Dosages of Amphetamine Upon Endurance.

ERIC Educational Resources Information Center

Williams, Melvin H.; Thompson, John

The purpose of this study was to provide basic information concerning the acute effects of a small, moderate, and large dose of d-amphetamine sulfate upon muscular endurance; a secondary purpose involved the effect upon resting (R), and submaximal, and maximal (MAX) heart rate (HR). Twelve male university students underwent four separate trials of…

Market Analysis. What Is It? How Does It Fit into Comprehensive Institutional Planning?

ERIC Educational Resources Information Center

Groff, Warren

The basic principles of market analysis are examined in this paper especially as they relate to institutional planning. Introductory material presents background information, including: (1) a description of two projects undertaken to implement modern management techniques at small colleges; (2) an examination of three marketing philosophies; and…

Probing Clouds in Planets with a Simple Radiative Transfer Model: The Jupiter Case

ERIC Educational Resources Information Center

Mendikoa, Inigo; Perez-Hoyos, Santiago; Sanchez-Lavega, Agustin

2012-01-01

Remote sensing of planets evokes using expensive on-orbit satellites and gathering complex data from space. However, the basic properties of clouds in planetary atmospheres can be successfully estimated with small telescopes even from an urban environment using currently available and affordable technology. This makes the process accessible for…

Small Things Draw Big Interest

ERIC Educational Resources Information Center

Green, Susan; Smith III, Julian

2005-01-01

Although the microscope is a basic tool in both physical and biological sciences, it is notably absent from most elementary school science programs. One reason teachers find it challenging to introduce microscopy at the elementary level is because children can have a hard time connecting the image of an object seen through a microscope with what…

An explicit microphysics thunderstorm model.

Treesearch

R. Solomon; C.M. Medaglia; C. Adamo; S. Dietrick; A. Mugnai; U. Biader Ceipidor

2005-01-01

The authors present a brief description of a 1.5-dimensional thunderstorm model with a lightning parameterization that utilizes an explicit microphysical scheme to model lightning-producing clouds. The main intent of this work is to describe the basic microphysical and electrical properties of the model, with a small illustrative section to show how the model may be...

Creswell's Energy Efficient Construction Program: A Big Project for a Small School.

ERIC Educational Resources Information Center

Kelsh, Bruce

1982-01-01

In Creswell (Oregon) High School's award winning vocational education program, students study energy efficient construction along with basic building skills. Part of the program has been the active recruitment of female, minority, disadvantaged, and handicapped students into the vocational area. Students have assembled solar hot water collectors,…

Stanwix House Vocabulary Study: Plurals. Investigative Report Number 7227.

ERIC Educational Resources Information Center

Wood, Penelope; Bond, Jack H.

Research analyzed: 1) the treatment of plurals in the Functional Basic Word List for Special Pupils (Stanwix House List), and 2) plural recognition by educable mentally handicapped (EMH) students. Review of the Stanwix House List revealed that plurals were treated as discrete vocabulary items. Using a small sample of EMH subjects, the researchers…

A Report on Deliverable Four: Develop a specifications list for a portable, lightweight prehospital suction device

DTIC Science & Technology

reflect it. There are commercially available manual and powered suction devices on the market , and several are specifically advertised for use in...combine to suggest that no device on the market meets even the most basic requirements of being small, lightweight, rugged, and demonstrating adequate

A Report on Deliverable Six: Develop a Concept Design for a Ruggedized, Lightweight, Portable, Powered Handheld Suction Device

DTIC Science & Technology

reflect it. There are commercially available manual and powered suction devices on the market , and several are specifically advertised for use in...combine to suggest that no device on the market meets even the most basic requirements of being small, lightweight, rugged, and demonstrating adequate

Combat Situation Awareness (CSA) Model-Based Characterizations of Marine Corps Training and Operations

DTIC Science & Technology

2010-12-01

nature of basic information exchange to an awareness of the environment. In addition, Experience played a very small role in SA Level 3 (Projection......ADMINISTRATIVE INFORMATION This report was prepared for prepared for the Office of Naval Research, Arlington, VA, by the Applied Research Branch, Space and

Leadership Qualities Found in Administrators Performing Simultaneous Duties Identified by Teacher Experiences

ERIC Educational Resources Information Center

Berry, Bennie S.

2014-01-01

The purpose of this basic qualitative research study was to explore the experiences of teachers in small rural school districts with an administrator that served as superintendent and principal simultaneously and reflect on what they identified as leadership qualities and characteristics. The participants were all teachers who worked in School…

Survey of L Band Tower and Airborne Sensor Systems Relevant to Upcoming Soil Moisture Missions

USDA-ARS?s Scientific Manuscript database

Basic research on the physics of microwave remote sensing of soil moisture has been conducted for almost thirty years using ground-based (tower- or truck-mounted) microwave instruments at L band frequencies. Early small point-scale studies were aimed at improved understanding and verification of mi...

Nonprofit Sector: Workforce Education Needs and Opportunities

ERIC Educational Resources Information Center

Garvey, David

2009-01-01

When some people think of nonprofit organizations, they think of small charities that are short-staffed, often struggle financially, and provide basic human needs to the most vulnerable in the society. Others think of organizations that support the civic and social infrastructure of communities, states, and nation, and serve as a vital component…

Be a Food Scientist

ERIC Educational Resources Information Center

Phillips, Sharon K.; Duffrin, Melani W.; Geist, Eugene A.

2004-01-01

Think about making something as basic as hard candy. The ingredients are simple--sugar, water, and flavoring--yet the changes that occur are chemically amazing. Drop by drop, small portions of the syrup placed in ice water indicate how saturated the solution is becoming, until a "crack" sound occurs when the candy is at hard-crack stage, its most…

75 FR 82581 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-48; Small Entity Compliance Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

..., Payrolls and Basic Records to delete the requirement for submission of full social security numbers and... requires contractors and subcontractors to maintain the full social security number and current address of... Wage and Hour Division of the Department of Labor for purposes of an investigation or audit of...

75 FR 22591 - Notice of Public Information Collection Being Reviewed by the Federal Communications Commission...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

...: Extension of a currently approved collection. Respondents: Businesses or other for-profit entities; State... collection of information. Needs and Uses: 47 CFR 76.934(e) states that small cable systems may obtain an... addressed to the local franchising authorities (``LFAs'') concerning rates for basic service tiers and...

[Project EXCEL: Curriculum for Just Desserts, Inc.: Modules 1-6.

ERIC Educational Resources Information Center

Career Resources Development Center, Inc., San Francisco, CA.

Six curriculum modules for Just Desserts, a San Francisco wholesale bakery company, are presented. Just Desserts was one of four small businesses involved in Project EXCEL, a workplace literacy project that focused on literacy and basic skills training for limited-English-proficient (LEP) workers. The modules are as follows: (1) Bakery Vocabulary…

Classrooms in the Workplace. Workplace Literacy Programs in Small and Medium-Sized Firms.

ERIC Educational Resources Information Center

Hollenbeck, Kevin

A study examined the characteristics and impact of workplace literacy programs in businesses with fewer than 500 employees. Particular emphasis was placed on workplace literacy initiatives in Michigan. Case studies and telephone surveys were conducted to determine the extent of basic skills deficiencies and incidence of workplace literacy…

Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever.

PubMed

Oestereich, Lisa; Lüdtke, Anja; Ruibal, Paula; Pallasch, Elisa; Kerber, Romy; Rieger, Toni; Wurr, Stephanie; Bockholt, Sabrina; Pérez-Girón, José V; Krasemann, Susanne; Günther, Stephan; Muñoz-Fontela, César

2016-05-01

Lassa fever (LASF) is a highly severe viral syndrome endemic to West African countries. Despite the annual high morbidity and mortality caused by LASF, very little is known about the pathophysiology of the disease. Basic research on LASF has been precluded due to the lack of relevant small animal models that reproduce the human disease. Immunocompetent laboratory mice are resistant to infection with Lassa virus (LASV) and, to date, only immunodeficient mice, or mice expressing human HLA, have shown some degree of susceptibility to experimental infection. Here, transplantation of wild-type bone marrow cells into irradiated type I interferon receptor knockout mice (IFNAR-/-) was used to generate chimeric mice that reproduced important features of severe LASF in humans. This included high lethality, liver damage, vascular leakage and systemic virus dissemination. In addition, this model indicated that T cell-mediated immunopathology was an important component of LASF pathogenesis that was directly correlated with vascular leakage. Our strategy allows easy generation of a suitable small animal model to test new vaccines and antivirals and to dissect the basic components of LASF pathophysiology.

Small Angle X-Ray Scattering from Lipid-Bound Myelin Basic Protein in Solution

PubMed Central

Haas, H.; Oliveira, C. L. P.; Torriani, I. L.; Polverini, E.; Fasano, A.; Carlone, G.; Cavatorta, P.; Riccio, P.

2004-01-01

The structure of myelin basic protein (MBP), purified from the myelin sheath in both lipid-free (LF-MBP) and lipid-bound (LB-MBP) forms, was investigated in solution by small angle x-ray scattering. The water-soluble LF-MBP, extracted at pH < 3.0 from defatted brain, is the classical preparation of MBP, commonly regarded as an intrinsically unfolded protein. LB-MBP is a lipoprotein-detergent complex extracted from myelin with its native lipidic environment at pH > 7.0. Under all conditions, the scattering from the two protein forms was different, indicating different molecular shapes. For the LB-MBP, well-defined scattering curves were obtained, suggesting that the protein had a unique, compact (but not globular) structure. Furthermore, these data were compatible with earlier results from molecular modeling calculations on the MBP structure which have been refined by us. In contrast, the LF-MBP data were in accordance with the expected open-coil conformation. The results represent the first direct structural information from x-ray scattering measurements on MBP in its native lipidic environment in solution. PMID:14695288

From chemical metabolism to life: the origin of the genetic coding process

PubMed Central

2017-01-01

Looking for origins is so much rooted in ideology that most studies reflect opinions that fail to explore the first realistic scenarios. To be sure, trying to understand the origins of life should be based on what we know of current chemistry in the solar system and beyond. There, amino acids and very small compounds such as carbon dioxide, dihydrogen or dinitrogen and their immediate derivatives are ubiquitous. Surface-based chemical metabolism using these basic chemicals is the most likely beginning in which amino acids, coenzymes and phosphate-based small carbon molecules were built up. Nucleotides, and of course RNAs, must have come to being much later. As a consequence, the key question to account for life is to understand how chemical metabolism that began with amino acids progressively shaped into a coding process involving RNAs. Here I explore the role of building up complementarity rules as the first information-based process that allowed for the genetic code to emerge, after RNAs were substituted to surfaces to carry over the basic metabolic pathways that drive the pursuit of life. PMID:28684991

NURSES’ PERCEPTIONS OF COMMUNICATION TRAINING IN THE ICU

PubMed Central

Radtke, Jill V.; Tate, Judith A.; Happ, Mary Beth

2011-01-01

Summary Objective To describe the experience and perceptions of nurse study participants regarding a communication intervention (training and communication tools) for use with nonspeaking, critically-ill patients. Research Methodology/Design Small focus groups and an individual interview were conducted with six critical care nurses. Transcripts were analysed using qualitative content analysis and constant comparison. Setting Two ICUs within a large, metropolitan medical centre in western Pennsylvania, United States of America. Main Outcome Measures Critical care nurses’ evaluations of (1) a basic communication skills training program (BCST) and (2) augmentative and alternative communication strategies (AAC) introduced during their study participation. Results Six main categories were identified in the data: 1) communication value/perceived competence; 2) communication intention; 3) benefits of training; 4) barriers to implementation; 5) preferences/utilization of strategies; and 6) leading-following. Perceived value of and individual competence in communication with nonspeaking patients varied. Nurses prioritized communication about physical needs, but recognized complexity of other intended patient messages. Nurses evaluated the BCST as helpful in reinforcing basic communication strategies and found several new strategies effective. Advanced strategies received mixed reviews. Primary barriers to practice integration included patients’ mental status, time constraints, and the small proportion of nurses trained or knowledgeable about best patient communication practices in the ICU. Conclusions The results suggest that the communication skills training program could be valuable in reinforcing basic/intuitive communication strategies, assisting in the acquisition of new skills, and ensuring communication supply availability. Practice integration will likely require unit-wide interdisciplinary dissemination, expert modelling and reinforcement. PMID:22172745

An investigation of rotor harmonic noise by the use of small scale wind tunnel models

NASA Technical Reports Server (NTRS)

Sternfeld, H., Jr.; Schaffer, E. G.

1982-01-01

Noise measurements of small scale helicopter rotor models were compared with noise measurements of full scale helicopters to determine what information about the full scale helicopters could be derived from noise measurements of small scale helicopter models. Comparisons were made of the discrete frequency (rotational) noise for 4 pairs of tests. Areas covered were tip speed effects, isolated rotor, tandem rotor, and main rotor/tail rotor interaction. Results show good comparison of noise trends with configuration and test condition changes, and good comparison of absolute noise measurements with the corrections used except for the isolated rotor case. Noise measurements of the isolated rotor show a great deal of scatter reflecting the fact that the rotor in hover is basically unstable.

Statistical Analysis of Small-Scale Magnetic Flux Emergence Patterns: A Useful Subsurface Diagnostic?

NASA Astrophysics Data System (ADS)

Lamb, Derek A.

2016-10-01

While sunspots follow a well-defined pattern of emergence in space and time, small-scale flux emergence is assumed to occur randomly at all times in the quiet Sun. HMI's full-disk coverage, high cadence, spatial resolution, and duty cycle allow us to probe that basic assumption. Some case studies of emergence suggest that temporal clustering on spatial scales of 50-150 Mm may occur. If clustering is present, it could serve as a diagnostic of large-scale subsurface magnetic field structures. We present the results of a manual survey of small-scale flux emergence events over a short time period, and a statistical analysis addressing the question of whether these events show spatio-temporal behavior that is anything other than random.

How morphometric characteristics affect flow accumulation values

NASA Astrophysics Data System (ADS)

Farek, Vladimir

2014-05-01

Remote sensing methods (like aerial based LIDAR recording, land-use recording etc.) become continually more available and accurate. On the other hand in-situ surveying is still expensive. Above all in small, anthropogenically uninfluenced catchments, with poor, or non-existing surveying network could be remote sensing methods extremely useful. Overland flow accumulation (FA) values belong to important indicators of higher flash floods or soil erosion exposure. This value gives the number of cells of the Digital Elevation Model (DEM) grid, which are drained to each point of the catchment. This contribution deals with relations between basic geomorphological and morphometric characteristics (like hypsometric integral, Melton index of subcatchment etc.) and FA values. These relations are studied in the rocky sandstone landscapes of National park Ceské Svycarsko with the particular occurrence of broken relief. All calculations are based on high-resolution LIDAR DEM named Genesis created by TU Dresden. The main computational platform is GIS GRASS . The goal of the conference paper is to submit a quick method or indicators to estimate small particular subcatchments threatened by higher flash floods or soil erosion risks, without the necessity of using sophisticated rainfall-runoff models. There is a possibility to split catchments easily to small subcatchments (or use existing disjunction), compute basic characteristics and (with knowledge of links between this characteristics and FA values) identify, which particular subcatchment is potentially threatened by flash floods or soil erosion.

Analysis of Operating Modes of Stand-Alone Series Controller of Power Flows for Overhead Power Transmission Lines

NASA Astrophysics Data System (ADS)

Astashev, M. G.; Panfilov, D. I.; Seregin, D. A.; Chernyshev, A. A.

2017-12-01

The features of using the bridge voltage inverter in small-size stand-alone series controllers of power flows (PFSC) for overhead power transmission lines (OPTL) are examined. The basic processes in the converter during transient and steady state modes were analyzed. The basic relations for calculating the electromagnetic processes taking into account the energy loss in the circuit and without it were received. A simulation model is proposed of a converter that makes it possible to study its operating modes during the formation of reactance introduced into the overhead power transmission line. The results of simulation of operating modes of the PFSC are presented.

The development of methods for predicting and measuring distribution patterns of aerial sprays. [Langley Vortex Research Facility

NASA Technical Reports Server (NTRS)

Ormsbee, A. I.; Bragg, M. B.; Maughmer, M. D.

1981-01-01

A set of relationships used to scale small sized dispersion studies to full size results are experimentally verified and, with some qualifications, basic deposition patterns are presented. In the process of validating these scaling laws, the basic experimental techniques used in conducting such studies both with and without an operational propeller were developed. The procedures that evolved are outlined in some detail. The envelope of test conditions that can be accommodated in the Langley Vortex Research Facility, which were developed theoretically, are verified using a series of vortex trajectory experiments that help to define the limitations due to wall interference effects for models of different sizes.

Historical overview of Intercosmos program

NASA Astrophysics Data System (ADS)

Rimsha, M. A.

1986-02-01

Fifteen years ago, on October 14, 1969, the artificial Earth satellite Intercosmos-1 was launched initiating joint satellite research conducted by scientists and specialists from friendly countries. A little more than 2 years were spent on the preparations for this launch. The first envoys of the Intercosmos program were comparatively small space vehicles. They consisted of three basic sections: a cylindrical middle section and two hemispheres. The first craft of the Intercosmos series achieved orientation on the Sun with an accuracy of a few angular degrees. The launch of the Intercosmos-1 satellite initiated one of the basic directions of research conducted in accordance with the program of space cooperation by the socialist countries--research on the solar-terrestrial ties using satellites.

Bayesian performance metrics and small system integration in recent homeland security and defense applications

NASA Astrophysics Data System (ADS)

Jannson, Tomasz; Kostrzewski, Andrew; Patton, Edward; Pradhan, Ranjit; Shih, Min-Yi; Walter, Kevin; Savant, Gajendra; Shie, Rick; Forrester, Thomas

2010-04-01

In this paper, Bayesian inference is applied to performance metrics definition of the important class of recent Homeland Security and defense systems called binary sensors, including both (internal) system performance and (external) CONOPS. The medical analogy is used to define the PPV (Positive Predictive Value), the basic Bayesian metrics parameter of the binary sensors. Also, Small System Integration (SSI) is discussed in the context of recent Homeland Security and defense applications, emphasizing a highly multi-technological approach, within the broad range of clusters ("nexus") of electronics, optics, X-ray physics, γ-ray physics, and other disciplines.

Small gas turbine combustor experimental study - Compliant metal/ceramic liner and performance evaluation

NASA Technical Reports Server (NTRS)

Acosta, W. A.; Norgren, C. T.

1986-01-01

Combustor research relating to the development of fuel efficient small gas turbine engines capable of meeting future commercial and military aviation needs is currently underway at NASA Lewis. As part of this combustor research, a basic reverse-flow combustor has been used to investigate advanced liner wall cooling techniques. Liner temperature, performance, and exhaust emissions of the experimental combustor utilizing compliant metal/ceramic liners were determined and compared with three previously reported combustors that featured: (1)splash film-cooled liner walls; (2) transpiration cooled liner walls; and (3) counter-flow film cooled panels.

Small gas turbine combustor experimental study: Compliant metal/ceramic liner and performance evaluation

NASA Technical Reports Server (NTRS)

Acosta, W. A.; Norgren, C. T.

1986-01-01

Combustor research relating to the development of fuel efficient small gas turbine engines capable of meeting future commercial and military aviation needs is currently underway at NASA Lewis. As part of this combustor research, a basic reverse-flow combustor has been used to investigate advanced liner wall cooling techniques. Liner temperature, performance, and exhaust emissions of the experimental combustor utilizing compliant metal/ceramic liners were determined and compared with three previously reported combustors that featured: (1) splash film-cooled liner walls; (2) transpiration cooled liner walls; and (3) counter-flow film cooled panels.

Stability of stationary solutions for inflow problem on the micropolar fluid model

NASA Astrophysics Data System (ADS)

Yin, Haiyan

2017-04-01

In this paper, we study the asymptotic behavior of solutions to the initial boundary value problem for the micropolar fluid model in a half-line R+:=(0,∞). We prove that the corresponding stationary solutions of the small amplitude to the inflow problem for the micropolar fluid model are time asymptotically stable under small H1 perturbations in both the subsonic and degenerate cases. The microrotation velocity brings us some additional troubles compared with Navier-Stokes equations in the absence of the microrotation velocity. The proof of asymptotic stability is based on the basic energy method.

Economic Impacts of Infrastructure Damages on Industrial Sector

NASA Astrophysics Data System (ADS)

Kajitani, Yoshio

This paper proposes a basic model for evaluating economic impacts on industrial sectors under the conditions that multiple infrastructures are simultaneously damaged during the earthquake disasters. Especially, focusing on the available economic data developed in the smallest spatial scale in Japan (small area statistics), economic loss estimation model based on the small area statistics and its applicability are investigated on. In the detail, a loss estimation framework, utilizing survey results on firms' activities under electricity, water and gas disruptions, and route choice models in Transportation Engineering, are applied to the case of 2004 Mid-Niigata Earthquake.

On the wide-range bias dependence of transistor d.c. and small-signal current gain factors.

NASA Technical Reports Server (NTRS)

Schmidt, P.; Das, M. B.

1972-01-01

Critical reappraisal of the bias dependence of the dc and small-signal ac current gain factors of planar bipolar transistors over a wide range of currents. This is based on a straightforward consideration of the three basic components of the dc base current arising due to emitter-to-base injected minority carrier transport, base-to-emitter carrier injection, and emitter-base surface depletion layer recombination effects. Experimental results on representative n-p-n and p-n-p silicon devices are given which support most of the analytical findings.

Risperidone Added to Parent Training and Stimulant Medication: Effects on Attention-Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder, Conduct Disorder, and Peer Aggression

PubMed Central

Gadow, Kenneth D.; Arnold, L. Eugene; Molina, Brooke S.G.; Findling, Robert L.; Bukstein, Oscar G.; Brown, Nicole V.; McNamara, Nora K.; Rundberg-Rivera, E. Victoria; Li, Xiaobai; Kipp, Heidi; Schneider, Jayne; Farmer, Cristan A.; Baker, Jennifer; Sprafkin, Joyce; Rice, Robert R.; Bangalore, Srihari S.; Butter, Eric M.; Buchan-Page, Kristin A.; Hurt, Elizabeth A.; Austin, Adrienne B.; Grondhuis, Sabrina N.; Aman, Michael G.

2014-01-01

Objective In this study, we aimed to expand on our prior research into the relative efficacy of combining parent training, stimulant medication and placebo (Basic) versus parent training, stimulant, and risperidone (Augmented) therapy by examining treatment effects for attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD) symptoms and peer aggression, symptom-induced—impairment, and informant discrepancy. Method Children (6-12 years; N=168) with severe physical aggression, ADHD, and co-occurring ODD/CD received an open trial of parent training and stimulant medication for 3 weeks. Participants failing to show optimal clinical response were randomly assigned to Basic or Augmented therapy for an additional 6 weeks. Results Compared with Basic therapy, children receiving Augmented therapy experienced greater reduction in parent-rated ODD severity (p=.02, Cohen's d=0.27) and peer aggression (p=.02, Cohen's d=0.32), but not ADHD or CD symptoms. Fewer children receiving Augmented (16%) than Basic (40%) therapy were rated by their parents as impaired by ODD symptoms at Week 9/endpoint (p=.008). Teacher ratings indicated greater reduction in ADHD severity (p=.02, Cohen's d =0.61) with Augmented therapy, but not for ODD or CD symptoms or peer aggression. Although both interventions were associated with marked symptom reduction, a relatively large percentage of children were rated impaired for at least one targeted disorder at Week 9/endpoint by parents (Basic 47%; Augmented 27%) and teachers (Basic 48%; Augmented 38%). Conclusion Augmented was superior to Basic therapy in reducing severity of ADHD and ODD symptoms, peer aggression, and symptom-induced impairment, but clinical improvement was generally context-specific, and effect sizes ranged from small to moderate. PMID:25151418

High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larsson, Daniel H.; Vågberg, William; Yaroshenko, Andre

X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-powermore » small-spot liquid-metal-jet electron-impact source. Lastly, the tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.« less

High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

DOE PAGES

Larsson, Daniel H.; Vågberg, William; Yaroshenko, Andre; ...

2016-12-13

X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-powermore » small-spot liquid-metal-jet electron-impact source. Lastly, the tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.« less

Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells.

PubMed

Mathapati, Santosh; Siller, Richard; Impellizzeri, Agata A R; Lycke, Max; Vegheim, Karianne; Almaas, Runar; Sullivan, Gareth J

2016-08-17

Hepatocyte-like cells (HLCs) generated in vitro from human pluripotent stem cells (hPSCs) provide an invaluable resource for basic research, regenerative medicine, drug screening, toxicology, and modeling of liver disease and development. This unit describes a small-molecule-driven protocol for in vitro differentiation of hPSCs into HLCs without the use of growth factors. hPSCs are coaxed through a developmentally relevant route via the primitive streak to definitive endoderm (DE) using the small molecule CHIR99021 (a Wnt agonist), replacing the conventional growth factors Wnt3A and activin A. The small-molecule-derived DE is then differentiated to hepatoblast-like cells in the presence of dimethyl sulfoxide. The resulting hepatoblasts are then differentiated to HLCs with N-hexanoic-Tyr, Ile-6 aminohexanoic amide (Dihexa, a hepatocyte growth factor agonist) and dexamethasone. The protocol provides an efficient and reproducible procedure for differentiation of hPSCs into HLCs utilizing small molecules. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

Optimal physiological structure of small neurons to guarantee stable information processing

NASA Astrophysics Data System (ADS)

Zeng, S. Y.; Zhang, Z. Z.; Wei, D. Q.; Luo, X. S.; Tang, W. Y.; Zeng, S. W.; Wang, R. F.

2013-02-01

Spike is the basic element for neuronal information processing and the spontaneous spiking frequency should be less than 1 Hz for stable information processing. If the neuronal membrane area is small, the frequency of neuronal spontaneous spiking caused by ion channel noise may be high. Therefore, it is important to suppress the deleterious spontaneous spiking of the small neurons. We find by simulation of stochastic neurons with Hodgkin-Huxley-type channels that the leakage system is critical and extremely efficient to suppress the spontaneous spiking and guarantee stable information processing of the small neurons. However, within the physiological limit the potassium system cannot do so. The suppression effect of the leakage system is super-exponential, but that of the potassium system is quasi-linear. With the minor physiological cost and the minimal consumption of metabolic energy, a slightly lower reversal potential and a relatively larger conductance of the leakage system give the optimal physiological structure to suppress the deleterious spontaneous spiking and guarantee stable information processing of small neurons, dendrites and axons.

CME Velocity and Acceleration Error Estimates Using the Bootstrap Method

NASA Technical Reports Server (NTRS)

Michalek, Grzegorz; Gopalswamy, Nat; Yashiro, Seiji

2017-01-01

The bootstrap method is used to determine errors of basic attributes of coronal mass ejections (CMEs) visually identified in images obtained by the Solar and Heliospheric Observatory (SOHO) mission's Large Angle and Spectrometric Coronagraph (LASCO) instruments. The basic parameters of CMEs are stored, among others, in a database known as the SOHO/LASCO CME catalog and are widely employed for many research studies. The basic attributes of CMEs (e.g. velocity and acceleration) are obtained from manually generated height-time plots. The subjective nature of manual measurements introduces random errors that are difficult to quantify. In many studies the impact of such measurement errors is overlooked. In this study we present a new possibility to estimate measurements errors in the basic attributes of CMEs. This approach is a computer-intensive method because it requires repeating the original data analysis procedure several times using replicate datasets. This is also commonly called the bootstrap method in the literature. We show that the bootstrap approach can be used to estimate the errors of the basic attributes of CMEs having moderately large numbers of height-time measurements. The velocity errors are in the vast majority small and depend mostly on the number of height-time points measured for a particular event. In the case of acceleration, the errors are significant, and for more than half of all CMEs, they are larger than the acceleration itself.

FOREST RECREATION FOR PROFIT, SELF-HELP SUGGESTIONS FOR RURAL AREAS DEVELOPMENT.

ERIC Educational Resources Information Center

Department of Agriculture, Washington, DC.

FARMERS AND OTHER LAND OWNERS CAN UTILIZE WOODLAND FOR PROFIT BY DEVELOPING RECREATION AREAS. CAMPGROUND AND PICNIC AREAS CAN PROVIDE ADDITIONAL INCOME AND CAN FIT IN WITH THE OPERATION OF OTHER SMALL BUSINESSES, SUCH AS A ROADSIDE STORE, A PRODUCE STAND, OR A FILLING STATION. BASIC CONSIDERATIONS IN PLANNING A RECREATION DEVELOPMENT INCLUDE--(1)…

Six Basic Plan Concepts Used for California School Housing. A Sequential Development from 1900 to Today.

ERIC Educational Resources Information Center

California State Dept. of Education, Sacramento. Bureau of School Planning.

A floor plan accompanies each of six chronologically arranged schemes for housing educational programs. Scheme A represents the in-line corridor plan whose main characteristics are--(1) double loaded corridors with fixed bearing walls, (2) single window walls providing minimal light and ventilation, and (3) small classrooms with fixed desks and…

Entrepreneurs: Women and Minorities.

ERIC Educational Resources Information Center

Akers, Lilialyce

A program was designed to meet the needs of Kentucky women who wished to supplement their incomes by producing articles in their homes for sale. Its three-phase objective was to identify women who already had knitting skills and train them to produce a finished product; to provide basic knowledge about how to run a small business; and to provide…

Tools. Unit 9: A Core Curriculum of Related Instruction for Apprentices.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of Occupational and Career Curriculum Development.

The tool handling unit is presented to assist apprentices to acquire a general knowledge on the use of various basic tools. The unit consists of seven modules: (1) introduction to hand tools and small power tools; (2) measuring tools: layout and measuring tools for woodworking; (3) measuring tools: feeler gauge, micrometer, and torque wrench; (4)…

Regional effects of vegetation restoration on water yield across the Loess Plateau, China

Treesearch

X. M. Feng; G. Sun; B. J. Fu; C. H. Su; Y. Liu; H. Lamparski

2012-01-01

The general relationships between vegetation and water yield under different climatic regimes are well established at a small watershed scale in the past century. However, applications of these basic theories to evaluate the regional effects of land cover change on water resources remain challenging due to the complex interactions of vegetation and climatic variability...

Visualization of Two Dimensional to Three Dimensional Transformations--Exploration through Technology

ERIC Educational Resources Information Center

Costa, G. B.; Gorak, M.; Melendez, B. S.

2006-01-01

A small class of functions is described that easily lend themselves to two-dimensional and three-dimensional visualizations at the basic calculus level. The intended audience is those educators involved in the instruction of elementary calculus. This note is an educational piece that begins with the question: "What happens if a function defined on…

Project EXCEL. Final Performance Report, March 1, 1991-October 31, 1992.

ERIC Educational Resources Information Center

Career Resources Development Center, Inc., San Francisco, CA.

Project EXCEL is a workplace literacy project involving four small business enterprises in San Francisco. Over a 19-month period, the project focused on literacy and basic skills training for 271 limited-English-proficient (LEP) workers. All training was conducted at the work sites, and a variety of support services were provided, including…

Substructure analysis techniques and automation. [to eliminate logistical data handling and generation chores

NASA Technical Reports Server (NTRS)

Hennrich, C. W.; Konrath, E. J., Jr.

1973-01-01

A basic automated substructure analysis capability for NASTRAN is presented which eliminates most of the logistical data handling and generation chores that are currently associated with the method. Rigid formats are proposed which will accomplish this using three new modules, all of which can be added to level 16 with a relatively small effort.

Checker Takes the Guesswork out of Diode Identification

ERIC Educational Resources Information Center

Harman, Charles

2011-01-01

At technical colleges and secondary-level tech schools, students enrolled in basic electronics labs who have learned about diodes that do rectification are used to seeing power diodes like the 1N4001. When the students are introduced to low-power zener diodes and signal diodes, component identification gets more complex. If the small zeners are…

Basic Number Processing Deficits in Developmental Dyscalculia: Evidence from Eye Tracking

ERIC Educational Resources Information Center

Moeller, K.; Neuburger, S.; Kaufmann, L.; Landerl, K.; Nuerk, H. C.

2009-01-01

Recent research suggests that developmental dyscalculia is associated with a subitizing deficit (i.e., the inability to quickly enumerate small sets of up to 3 objects). However, the nature of this deficit has not previously been investigated. In the present study the eye-tracking methodology was employed to clarify whether (a) the subitizing…

Measuring Marbles: Demonstrating the Basic Tenets of Measurement Theory

ERIC Educational Resources Information Center

Wininger, Steven R.

2007-01-01

A hands-on activity is described in which students attempt to measure something that they cannot see. In small groups, students estimate the number of marbles in sealed boxes. Next, students' estimates are compared with the actual numbers. Last, values from both the students' estimates and actual numbers are used to explain measurement theory and…

Paradoxes in Film Ratings

ERIC Educational Resources Information Center

Moore, Thomas L.

2006-01-01

The author selected a simple random sample of 100 movies from the "Movie and Video Guide" (1996), by Leonard Maltin. The author's intent was to obtain some basic information on the population of roughly 19,000 movies through a small sample. The "Movie and Video Guide" by Leonard Maltin is an annual ratings guide to movies. While not all films ever…

Long-term effects of elevated carbon dioxide on sour orange tree specific gravity and anatomy

Treesearch

Michael C. Wiemann; David Kretschmann; Alan Rudie; Bruce A. Kimball; Sherwood B. Idso

2008-01-01

Exposure to elevated levels of atmospheric CO2 for a period of 17 years resulted in small but statistically significant decreases in wood basic specific gravity and number of rays per millimeter. Other anatomical characteristics (percentages of tissues, number of vessels per square millimeter, vessel diameters, and fiber wall thickness) were...

First Steps to Endangered Language Documentation: The Kalasha Language, a Case Study

ERIC Educational Resources Information Center

Mela-Athanasopoulou, Elizabeth

2011-01-01

The present paper based on extensive fieldwork D conducted on Kalasha, an endangered language spoken in the three small valleys in Chitral District of Northwestern Pakistan, exposes a spontaneous dialogue-based elicitation of linguistic material used for the description and documentation of the language. After a brief display of the basic typology…

Teaching First-Aid Skills to Students with Moderate Handicaps in Small Group Instruction.

ERIC Educational Resources Information Center

Gast, David L.; And Others

1992-01-01

Task analysis and backward chaining were used to teach four young adults with moderate mental disabilities basic first aid skills for simulated cuts, burns, and insect bites. Following training, students were able to apply skills to a nonhandicapped peer. Maintenance probes at 1 to 18 weeks posttraining indicated mixed results. Social validation…

SMEs and Electronic Commerce: A Departure from the Traditional Prioritisation of Training?

ERIC Educational Resources Information Center

Barry, Helen; Milner, Brigid

2002-01-01

A survey of 56 small/medium-sized Irish enterprises showed that 46% were highly proficient in electronic commerce, 42% were at the basic level. Media pressure significantly influenced adoption. In 40% of firms, owner-managers were the driving force. E-commerce was not yet business critical and relevant training was not yet a comprehensive…

Small Farm Grain Storage. Appropriate Technologies for Development. Manual M-2.

ERIC Educational Resources Information Center

Lindblad, Carl; Druben, Laurel

Designed as a working and teaching tool for development workers in their field activities, this manual combines in one volume the basic principles of grain storage and the practical solutions currently being used and tested around the world to combat grain storage problems. Each of six sections begins with informative material on the topic to be…

Public Marketing: An Alternative Policy Decision-Making Idea for Small Cities. Community Development Research Series.

ERIC Educational Resources Information Center

Meyers, James; And Others

The concept of public marketing presents a strategy for the systems approach to community development that would facilitate the community decision making process via improved communication. Basic aspects of the social marketing process include: (1) product policy; (2) channels of distribution; (3) pricing (perceived price vs quality and quantity…

Demonstration Experiments for Solid-State Physics Using a Table-Top Mechanical Stirling Refrigerator

ERIC Educational Resources Information Center

Osorio, M. R.; Morales, A. Palacio; Rodrigo, J. G.; Suderow, H.; Vieira, S.

2012-01-01

Liquid-free cryogenic devices are acquiring importance in basic science and engineering. But they can also lead to improvements in teaching low temperature and solid-state physics to graduate students and specialists. Most of the devices are relatively expensive, but small-sized equipment is slowly becoming available. Here, we have designed…

Statistical techniques for sampling and monitoring natural resources

Treesearch

Hans T. Schreuder; Richard Ernst; Hugo Ramirez-Maldonado

2004-01-01

We present the statistical theory of inventory and monitoring from a probabilistic point of view. We start with the basics and show the interrelationships between designs and estimators illustrating the methods with a small artificial population as well as with a mapped realistic population. For such applications, useful open source software is given in Appendix 4....

Anti-Angiogenic Action of Neutral Endopeptidase

DTIC Science & Technology

2006-11-01

natriuretic factor, substance P , bradykinin, oxytocin, Leu- and Met-enkephalins, neurotensin, bombesin, endothelin-1 (ET-1), and beta amyloid. Loss...NOTES 14. ABSTRACT: Please see attached. 15. SUBJECT TERMS Angiogenesis, Cell surface peptidase , Neutral endopeptidase, Basic fibroblast growth...effective therapies for patients with prostate cancer. Cell-surface peptidases are the guardians of the cell against small stimulatory peptides

Anti-Angiogenic Action of Neutral Endopeptidase

DTIC Science & Technology

2005-11-30

side of hydrophobic amino acids and inactivates a variety of physiologically active peptides, including atrial natriuretic factor, substance P ...follows. 15. SUBJECT TERMS Angiogenesis, Cell surface peptidase , Neutral endopeptidase, Basic fibroblast growth factor, Prostate cancer Proteolysis 16...patients with prostate cancer. Cell-surface peptidases are the guardians of the cell against small stimulatory peptides, functioning to control growth

Exploratory Inquiry: Fundraising at Historically Black Colleges and Universities to Reduce Resource Dependence

ERIC Educational Resources Information Center

Mills Campbell, Dawn

2017-01-01

Resource dependence has been evidenced among private HBCUs that obtain as much as 90% of operating revenue from tuition and fees. Without alternative funding strategies in place, small declines in enrollment can lead to a major budget crisis. The basic premise of this exploratory inquiry was that fundraising represents an opportunity that has been…

Teachers' Manual: Using Teams-Games-Tournament (TGT) in the Physical Science Classroom.

ERIC Educational Resources Information Center

Hollifield, John H.; Leavey, Marshall B.

This teacher's manual provides general and specific guidelines for use of Teams-Games-Tournaments (TGT) Physical Science Curriculum materials at the junior high-middle school level. TGT is an innovative instructional model which focuses on the learning of basic skills, information, and concepts, rewarding students in small teams rather than at the…

A Constrained Bureaucratic Model of Behavioral Responses to School Finance Reform

ERIC Educational Resources Information Center

Ullrich, Laura D.; Murray, Matthew N.

2017-01-01

"Tennessee Small School Systems v. McWherter" case led to a significant reform of the state's school finance system during 1992-1993 with the phased-in implementation of the Basic Education Program. This paper examines the impact of Tennessee's school finance reform on education spending using a complete panel of school districts from…

A Report on Deliverable One: Determine Required Performance Characteristics [of Suction] for Management Of Prehospital Combat Casualty Care Injuries

DTIC Science & Technology

reflect it. There are commercially available manual and powered suction devices on the market , and several are specifically advertised for use in...combine to suggest that no device on the market meets even the most basic requirements of being small, lightweight, rugged, and demonstrating adequate

Going off the Grid: Re-Examining Technology in the Basic Writing Classroom

ERIC Educational Resources Information Center

Clay-Buck, Holly; Tuberville, Brenda

2015-01-01

The notion that today's students are constantly exposed to information technology has become so pervasive that it seems the academic conversation assumes students are "tech savvy." The proliferation of apps and smart phones aimed at the traditional college-aged population feeds into this assumption, aided in no small part by a growing…

Integrating Technology in Today's Undergraduate Classrooms: A Look at Students' Perspectives

ERIC Educational Resources Information Center

Meehan, Kimberly C.; Salmun, Haydee

2016-01-01

The authors present the findings of a small-scale study of student opinions drawn from an anonymous and voluntary survey in an undergraduate science classroom. The survey questions focused on the use of basic tools in a college classroom. The tools included in the survey were PowerPoint, overhead projectors/chalkboards, personal response units,…

Landscape-level influences of terrestrial snake occupancy within the southeastern United States

Treesearch

David A. Steen; Christopher J. W. McClure; Jean C. Brock; D. Craig Rudolph; Josh B. Pierce; James R. Lee; W. Jeffrey Humphries; Beau B. Gregory; William B. Sutton; Lora L. Smith; Danna L. Baxley; Dirk J. Stevenson; Craig Guyer

2012-01-01

Habitat loss and degradation are thought to be the primary drivers of species extirpations, but for many species we have little information regarding specific habitats that influence occupancy. Snakes are of conservation concern throughout North America, but effective management and conservation are hindered by a lack of basic natural history information and the small...

Characterization of Juvenile wood in Lodgepole Pine in the Intermountain West

Treesearch

Thomas M. Gorman; David E. Kretschmann

2012-01-01

Juvenile wood (core wood) is typically characterized as being less dimensionally stable and having lower mechanical properties than mature wood. Determination of the age of transition from juvenile wood to mature wood can provide basic information needed to assess dimensional stability and better utilize small-diameter trees growing in the intermountain west as solid-...

Scout Launch Lift off on Wallops Island

NASA Image and Video Library

1965-08-10

Scout launch vehicle lift off on Wallops Island in 1965. The Scout launch vehicle was used for unmanned small satellite missions, high altitude probes, and reentry experiments. Scout, the smallest of the basic launch vehicles, is the only United States launch vehicle fueled exclusively with solid propellants. Published in the book " A Century at Langley" by Joseph Chambers pg. 92

Racism, Union Busting, or Just Plain Cultural Conflict?

ERIC Educational Resources Information Center

Stryker, Don; Bergerson, Amy Aldous

2012-01-01

This case describes the struggle of a small school employee association located in a right-to-work state as it attempts to continue exercising influence after a political turmoil caused the composition of the school board to change. This case presents many elements that foster discussion of basic employee rights such as freedom of association,…

Geospatial application of the Water Erosion Prediction Project (WEPP) model

Treesearch

D. C. Flanagan; J. R. Frankenberger; T. A. Cochrane; C. S. Renschler; W. J. Elliot

2013-01-01

At the hillslope profile and/or field scale, a simple Windows graphical user interface (GUI) is available to easily specify the slope, soil, and management inputs for application of the USDA Water Erosion Prediction Project (WEPP) model. Likewise, basic small watershed configurations of a few hillslopes and channels can be created and simulated with this GUI. However,...

The application and technology of implantable neuromuscular stimulators: an introduction and overview.

PubMed

Jarvis, J C; Salmons, S

2001-01-01

The design of an implantable neuromuscular stimulator represents a trade-off in which the desire to maximise functionality and operational life competes with the need for the implanted device to be small, reliable, safe, and easy to use. In this introduction and overview we consider the basic problems and the different approaches to their solution.

Selecting and Using a Core-Reference Collection. Second Edition.

ERIC Educational Resources Information Center

Nichols, Margaret Irby

Core-reference collections are the small number of sources which meet the basic needs of all libraries, and the purpose of this guide is to assist libraries in the selection, acquisition, and use of these resources. Section I, structured like an annotated bibliography, focuses on the selection of those works which should constitute the main…

Small Form Factor Information Storage Devices for Mobile Applications in Korea

NASA Astrophysics Data System (ADS)

Park, Young-Pil; Park, No-Cheol; Kim, Chul-Jin

Recently, the ubiquitous environment in which anybody can reach a lot of information data without any limitations on the place and time has become an important social issue. There are two basic requirements in the field of information storage devices which have to be satisfied; the first is the demand for the improvement of memory capacity to manage the increased data capacity in personal and official purposes. The second is the demand for new development of information storage devices small enough to be applied to mobile multimedia digital electronics, including digital camera, PDA and mobile phones. To summarize, for the sake of mobile applications, it is necessary to develop information storage devices which have simultaneously a large capacity and a small size. Korea possesses the necessary infrastructure for developing such small sized information storage devices. It has a good digital market, major digital companies, and various research institutes. Nowadays, many companies and research institutes including university cooperate together in the research on small sized information storage devices. Thus, it is expected that small form factor optical disk drives will be commercialized in the very near future in Korea.

The National Heart, Lung, and Blood Institute Small Business Program

PubMed Central

Marek, Kurt W.

2016-01-01

SUMMARY Small companies working to develop products in the cardiovascular space face numerous challenges, from regulatory, intellectual property, and reimbursement barriers to securing funds to keep the lights on and reach the next development milestone. Most small companies that spin out from universities have the scientific knowledge, but product development expertise and business acumen are also needed to be successful. Other challenges include reduced interest in early stage technologies (Pharma & Biotech 2015 in Review, EP Vantage) and limited deal flow for cardiovascular products (Gormley B., Wall Street Journal, September 15, 2014). The NHLBI small business program is a comprehensive ecosystem designed to address these critical challenges and to provide resources and expertise to assist early stage companies developing cardiovascular and other products within the institute’s mission. This article describes steps that NHLBI has taken to enhance our small business program to more effectively translate basic discoveries into commercial products to benefit patients and public health, including enhancing internal expertise and developing non-financial resources to assist small businesses as they develop their products and seek private sector investment and partnership. PMID:28580435

The National Heart, Lung, and Blood Institute Small Business Program: A Comprehensive Ecosystem for Biomedical Product Development.

PubMed

Marek, Kurt W

2016-12-01

Small companies working to develop products in the cardiovascular space face numerous challenges, from regulatory, intellectual property, and reimbursement barriers to securing funds to keep the lights on and reach the next development milestone. Most small companies that spin out from universities have the scientific knowledge, but product development expertise and business acumen are also needed to be successful. Other challenges include reduced interest in early stage technologies (Pharma & Biotech 2015 in Review, EP Vantage) and limited deal flow for cardiovascular products (Gormley B., Wall Street Journal, September 15, 2014). The NHLBI small business program is a comprehensive ecosystem designed to address these critical challenges and to provide resources and expertise to assist early stage companies developing cardiovascular and other products within the institute's mission. This article describes steps that NHLBI has taken to enhance our small business program to more effectively translate basic discoveries into commercial products to benefit patients and public health, including enhancing internal expertise and developing non-financial resources to assist small businesses as they develop their products and seek private sector investment and partnership.

Molecular sled sequences are common in mammalian proteins.

PubMed

Xiong, Kan; Blainey, Paul C

2016-03-18

Recent work revealed a new class of molecular machines called molecular sleds, which are small basic molecules that bind and slide along DNA with the ability to carry cargo along DNA. Here, we performed biochemical and single-molecule flow stretching assays to investigate the basis of sliding activity in molecular sleds. In particular, we identified the functional core of pVIc, the first molecular sled characterized; peptide functional groups that control sliding activity; and propose a model for the sliding activity of molecular sleds. We also observed widespread DNA binding and sliding activity among basic polypeptide sequences that implicate mammalian nuclear localization sequences and many cell penetrating peptides as molecular sleds. These basic protein motifs exhibit weak but physiologically relevant sequence-nonspecific DNA affinity. Our findings indicate that many mammalian proteins contain molecular sled sequences and suggest the possibility that substantial undiscovered sliding activity exists among nuclear mammalian proteins. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Effects of Reinforcement Method of Dissection Physiology Education on the Achievement in Pharmacology.

PubMed

Kitayama, Tomoya; Kagota, Satomi; Yoshikawa, Noriko; Kawai, Nobuyuki; Nishimura, Kanae; Miura, Takeshi; Yasui, Naomi; Shinozuka, Kazumasa; Nakabayashi, Toshikatsu

2016-01-01

The Pharmaceutical Education Support Center was established in the Department of Pharmacy at the School of Pharmacy and Pharmaceutical Science of Mukogawa Women's University in 2014. We started teaching first and second years students according to proficiency from the 2014 academic year. Students were divided into two classes: the regular class (high proficiency class) and the basic class (low proficiency class), based on achievement in several basic subjects related to the study of pharmacy. The staffs in the Pharmaceutical Education Support Center reinforce what is taught to students in the basic class. In this reinforcement method of education, the class size is small, consisting of about 15 students, a quiz to review the previous lesson is given at the beginning of each lecture, and an additional five lectures are conducted, compared to the high proficiency class, which receives 15 lectures. In this study, we evaluated the effects of the reinforcement method of physiology education on achievement in pharmacology that was not conducted in the proficiency-dependent teaching method. The students in the basic class in physiology education were chosen based on achievement levels in anatomy. Achievement levels of pharmacology students in the basic class of physiology improved compared with those of students who had the same achievement levels in physiology but were not taught according to proficiency-dependent teaching in the 2013 academic year. These results suggest that the reinforcement method for education in basic subjects in pharmacy, such as physiology, can improve achievement in more advanced subjects, such as pharmacology.

Integration of basic science and clinical medicine: the innovative approach of the cadaver biopsy project at the Boston University School of Medicine.

PubMed

Eisenstein, Anna; Vaisman, Lev; Johnston-Cox, Hillary; Gallan, Alexander; Shaffer, Kitt; Vaughan, Deborah; O'Hara, Carl; Joseph, Lija

2014-01-01

Curricular integration has emerged as a consistent theme in medical education reform. Vertical integration of topics such as pathology offers the potential to bring basic science content into the clinical arena, but faculty/student acceptance and curricular design pose challenges for such integration. The authors describe the Cadaver Biopsy Project (CBP) at Boston University School of Medicine as a sustainable model of vertical integration. Faculty and select senior medical students obtained biopsies of cadavers during the first-year gross anatomy course (fall 2009) and used these to develop clinical cases for courses in histology (spring 2010), pathology (fall 2010-spring 2011), and radiology (fall 2011 or spring 2012), thereby linking students' first experiences in basic sciences with other basic science courses and later clinical courses. Project goals included engaging medical stu dents in applying basic science princi ples in all aspects of patient care as they acquire skills. The educational intervention used a patient (cadaver)-centered approach and small-group, collaborative, case-based learning. Through this project, the authors involved clinical and basic science faculty-plus senior medical students-in a collaborative project to design and implement an integrated curriculum through which students revisited, at several different points, the microscopic structure and pathophysiology of common diseases. Developing appropriate, measurable out comes for medical education initiatives, including the CBP, is challenging. Accumu lation of qualitative feedback from surveys will guide continuous improvement of the CBP. Documenting longer-term impact of the curricular innovation on test scores and other competency-based outcomes is an ultimate goal.

Development of the New Educational Content "small Uas in Civil Engineering Application Scenarios"

NASA Astrophysics Data System (ADS)

Levin, E.; Vach, K.; Shults, R.

2017-12-01

The key point of this paper is presentation of the main idea and some results of the project "Small UAS in civil engineering application scenarios" (SUAS-CAS). This project was proposed by newly established in 2016 ISPRS WG V/7: "Innovative Technologies in Training Civil Engineers and Architects". Here we are presenting our experience in using low-cost UAS in training architects at Kyiv National University of Construction and Architecture, which was chosen as basic for this project. In the first part of paper, the project outline is presented. Then the first and possible follow project outcomes were described. In some details is described the training module "Small UAS in architecture" which was developed and included as a part of the subject "Architectural photogrammetry".

Design studies of large aperture, high-resolution Earth science microwave radiometers compatible with small launch vehicles

NASA Technical Reports Server (NTRS)

Schroeder, Lyle C.; Bailey, M. C.; Harrington, Richard F.; Kendall, Bruce M.; Campbell, Thomas G.

1994-01-01

High-spatial-resolution microwave radiometer sensing from space with reasonable swath widths and revisit times favors large aperture systems. However, with traditional precision antenna design, the size and weight requirements for such systems are in conflict with the need to emphasize small launch vehicles. This paper describes tradeoffs between the science requirements, basic operational parameters, and expected sensor performance for selected satellite radiometer concepts utilizing novel lightweight compactly packaged real apertures. Antenna, feed, and radiometer subsystem design and calibration are presented. Preliminary results show that novel lightweight real aperture coupled with state-of-the-art radiometer designs are compatible with small launch systems, and hold promise for high-resolution earth science measurements of sea ice, precipitation, soil moisture, sea surface temperature, and ocean wind speeds.

Hubble Space Telescope: Faint object camera instrument handbook. Version 2.0

NASA Technical Reports Server (NTRS)

Paresce, Francesco (Editor)

1990-01-01

The Faint Object Camera (FOC) is a long focal ratio, photon counting device designed to take high resolution two dimensional images of areas of the sky up to 44 by 44 arcseconds squared in size, with pixel dimensions as small as 0.0007 by 0.0007 arcseconds squared in the 1150 to 6500 A wavelength range. The basic aim of the handbook is to make relevant information about the FOC available to a wide range of astronomers, many of whom may wish to apply for HST observing time. The FOC, as presently configured, is briefly described, and some basic performance parameters are summarized. Also included are detailed performance parameters and instructions on how to derive approximate FOC exposure times for the proposed targets.

Student-initiated revision in child health.

PubMed

Alfaham, M; Gray, O P; Davies, D P

1994-03-01

Most teaching of child health in Cardiff takes place in block attachments of 8 weeks. There is an introductory seminar of 2 days followed by a 6-week clinical attachment in a district general hospital in Wales, and then a revision period of one week designed to help students formalize and structure their basic knowledge and to clarify aspects of child health which they may have had difficulty in understanding. The revision programme has to take into account: the short time available, the small number of teaching staff, the most relevant basic knowledge and active participation by the student. This paper describes how this week has been improved through the use of student-initiated revision (SIR). The students' appraisal of this revision and in particular SIR is presented.

Enhancing instruction scheduling with a block-structured ISA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melvin, S.; Patt, Y.

It is now generally recognized that not enough parallelism exists within the small basic blocks of most general purpose programs to satisfy high performance processors. Thus, a wide variety of techniques have been developed to exploit instruction level parallelism across basic block boundaries. In this paper we discuss some previous techniques along with their hardware and software requirements. Then we propose a new paradigm for an instruction set architecture (ISA): block-structuring. This new paradigm is presented, its hardware and software requirements are discussed and the results from a simulation study are presented. We show that a block-structured ISA utilizes bothmore » dynamic and compile-time mechanisms for exploiting instruction level parallelism and has significant performance advantages over a conventional ISA.« less

The Physics of a Gymnastics Flight Element

NASA Astrophysics Data System (ADS)

Contakos, Jonas; Carlton, Les G.; Thompson, Bruce; Suddaby, Rick

2009-09-01

From its inception, performance in the sport of gymnastics has relied on the laws of physics to create movement patterns and static postures that appear almost impossible. In general, gymnastics is physics in motion and can provide an ideal framework for studying basic human modeling techniques and physical principles. Using low-end technology and basic principles of physics, we analyzed a high-end gymnastics skill competed in by both men and women. The comprehensive goal of the examination is to scientifically understand how a skill of this magnitude is actually physically possible and what must a gymnast do to successfully complete the skill. The examination is divided into three sections, each of which is comprehensive enough to be a separate assignment or small group project.

The solar-flare infrared continuum - Observational techniques and upper limits

NASA Technical Reports Server (NTRS)

Hudson, H. S.

1975-01-01

Exploratory observations at 20 microns and 350 microns have determined detection thresholds for solar flares in these wavelengths. In the 20-micron range, solar atmospheric fluctuations (the 'temperature field') set the basic limits on flare detectability at about 5 K; at 350 microns, extinction in the earth's atmosphere provides the basic limitation of about 30 K. These thresholds are low enough for the successful detection of several infrared-emitting components of large flares. The upper limits obtained for subflares indicate that the thickness of the H-alpha flare region does not exceed approximately 10 km. This result confirms the conclusion of Suemoto and Hiei (1959) regarding the small effective thickness of the H-alpha-emitting regions in solar flares.

Quantum dots in bio-imaging: Revolution by the small

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arya, Harinder; Kaul, Zeenia; Wadhwa, Renu

2005-04-22

Visual analysis of biomolecules is an integral avenue of basic and applied biological research. It has been widely carried out by tagging of nucleotides and proteins with traditional fluorophores that are limited in their application by features such as photobleaching, spectral overlaps, and operational difficulties. Quantum dots (QDs) are emerging as a superior alternative and are poised to change the world of bio-imaging and further its applications in basic and applied biology. The interdisciplinary field of nanobiotechnology is experiencing a revolution and QDs as an enabling technology have become a harbinger of this hybrid field. Within a decade, research onmore » QDs has evolved from being a pure science subject to the one with high-end commercial applications.« less

An efficient liner cooling scheme for advanced small gas turbine combustors

NASA Technical Reports Server (NTRS)

Paskin, Marc D.; Mongia, Hukam C.; Acosta, Waldo A.

1993-01-01

A joint Army/NASA program was conducted to design, fabricate, and test an advanced, small gas turbine, reverse-flow combustor utilizing a compliant metal/ceramic (CMC) wall cooling concept. The objectives of this effort were to develop a design method (basic design data base and analysis) for the CMC cooling technique and then demonstrate its application to an advanced cycle, small, reverse-flow combustor with 3000 F burner outlet temperature. The CMC concept offers significant improvements in wall cooling effectiveness resulting in a large reduction in cooling air requirements. Therefore, more air is available for control of burner outlet temperature pattern in addition to the benefits of improved efficiency, reduced emissions, and lower smoke levels. The program was divided into four tasks. Task 1 defined component materials and localized design of the composite wall structure in conjunction with development of basic design models for the analysis of flow and heat transfer through the wall. Task 2 included implementation of the selected materials and validated design models during combustor preliminary design. Detail design of the selected combustor concept and its refinement with 3D aerothermal analysis were completed in Task 3. Task 4 covered detail drawings, process development and fabrication, and a series of burner rig tests. The purpose of this paper is to provide details of the investigation into the fundamental flow and heat transfer characteristics of the CMC wall structure as well as implementation of the fundamental analysis method for full-scale combustor design.

Practical ways to facilitate ergonomics improvements in occupational health practice.

PubMed

Kogi, Kazutaka

2012-12-01

Recent advances in participatory programs for improving workplace conditions are discussed to examine practical ways to facilitate ergonomics improvements. Participatory training programs are gaining importance, particularly in promoting occupational health and safety in small-scale workplaces. These programs have led to many improvements that can reduce work-related risks in varied situations. Recent experiences in participatory action-oriented training programs in small workplaces and agriculture are reviewed.The emphasis of the review is on training steps, types of improvements achieved, and the use of action tools by trainers and training participants. Immediate improvements in multiple technical areas are targeted, including materials handling,workstation design, physical environment, welfare facilities, and work organization. In facilitating ergonomics improvements in each local situation, it is important to focus on (a) building on local good practices; (b) applying practical, simple improvements that apply the basic principles of ergonomics; and (c) developing action-oriented toolkits for direct use by workers and managers. This facilitation process is effective when locally designed action toolkits are used by trainers, including local good examples, action checklists, and illustrated how-to guides. Intervention studies demonstrate the effectiveness of participatory steps that use these toolkits in promoting good practices and reducing work-related risks. In facilitating ergonomics improvements in small-scale workplaces, it is important to focus on practical, low-cost improvements that build on local good practices. The use of action-oriented toolkits reflecting basic ergonomics principles is helpful.The promotion of the intercountry networking of positive experiences in participatory training is suggested.

[Public policies of research].

PubMed

Ruiz Cantero, M T; Alvarez-Dardet, C

1995-01-01

With its present configuration, the Spanish public device of research in health sciences has limited possibilities to achieve properly the aims of the Ley General de Sanidad, due to its reduced financial importance as well as its thematic and lack of mechanisms of interterritorial compensation. These limitations are effective according to its small capacity to provide information for the development of a health system, oriented to the overcoming of territorial and social imbalance as well as the promotion of health and prevention of diseases. The capacity of public policies of research in Spain to affect the work of researchers is very small due to the importance of the widespread practice of not using funds which are not specifically dedicated to research of the institutions employing the researchers, among other reasons. Most of the public resources of research are concentrated in Madrid and Barcelona. This situation can seriously jeopardize in a near future the development and quality of the attention given in Regional Health Services transferred to Autonomic Communities without big cities. The funds are mostly used to finance researches of basic sciences, medical specialties and clinic laboratories. Investigation in Public Health is only 0.8% of the research budgets, and the funds dedicated to research in Health Primary Care are also very small. The present predominant thematic and methodological orientation of health research in our country, with medicalized research aims, subindividual observation units, experimental designs, and analysis which are basically quantitative, can endanger the possibilities of Spain to achieve the health aims established by the OMS.

SUMMARY OF ACCOMPLISHMENTS AND DISAPPOINTMENTS, TUSKEGEE INSTITUTE-OEO SEASONALLY EMPLOYED AGRICULTURAL WORKERS EDUCATIONAL PROJECT, NOVEMBER 1, 1966-OCTOBER 31, 1967.

ERIC Educational Resources Information Center

PINNOCK, THEODORE J.; TAYLOR, G.W.

THE SEASONALLY EMPLOYED AGRICULTURAL WORKERS PROGRAM WAS SPONSORED BY TUSKEGEE INSTITUTE, UNDER THE AUSPICES OF THE OFFICE OF ECONOMIC OPPORTUNITY, TO PROVIDE BASIC AND PREVOCATIONAL EDUCATION AND NEW GOALS FOR 1,239 FUNCTIONAL ILLITERATES, MOST OF THEM OWNERS OF SMALL FARMS, IN SEVEN ALABAMA COUNTIES. FAMILIES WERE HELPED TO IMPROVE THEIR…

Small Unit Decision Making (SUDM) Assessment Battery

DTIC Science & Technology

2014-11-21

largest contribution towards differentiating between the performance level of the NCO and Lt groups participating in the project. Two additional...Situational Judgment Test, made the largest contribution towards differentiating between the performance level of NCOs and Lts. Additionally, two other...basic perceptual skills. For the construct of cognitive flexibility we suggest the development of a performance instrument in line with our definition

Learning Environment: An Architectural Interpretation of a New Designs Archetype High School.

ERIC Educational Resources Information Center

Jilk, Bruce A.; And Others

The New Designs for the Comprehensive High School project used the break-the-mold design-down process to develop a prototype high school. The basic building block of this design is the personal workstation, not the classroom. Combining the personal workstation with the desire for teaming leads to the idea of a small, flexible group space that…

29 CFR Appendix V to Part 1918 - Basic Elements of a First Aid Training Program (Non-mandatory)

Code of Federal Regulations, 2011 CFR

2011-07-01

...-mandatory) V Appendix V to Part 1918 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND...) Side Stress on Boom .66(b)(3)(i) Vessel's Permanent Equipment .55 Visible Defects .66(b)(3)(ii) Cups... Related Employments .2 River Towboat .2 Small Trimming Hatch .2 Vessel .2 Vessel's Cargo Handling Gear .2...

29 CFR Appendix V to Part 1918 - Basic Elements of a First Aid Training Program (Non-mandatory)

Code of Federal Regulations, 2012 CFR

2012-07-01

...-mandatory) V Appendix V to Part 1918 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND...) Side Stress on Boom .66(b)(3)(i) Vessel's Permanent Equipment .55 Visible Defects .66(b)(3)(ii) Cups... Related Employments .2 River Towboat .2 Small Trimming Hatch .2 Vessel .2 Vessel's Cargo Handling Gear .2...

Extension Strategies for Poverty Alleviation: Lessons from China and India

ERIC Educational Resources Information Center

Swanson, Burton E.

2006-01-01

This paper discusses the transition from a national focus on food security during the last half of the 20th century to an emerging strategy on helping small-scale farm households increase farm income to reduce rural poverty. The basic proposition is that if extension is going to help increase farm incomes and rural employment, then it must shift…

Physics in Movies: Awareness Levels of Teacher Candidates

ERIC Educational Resources Information Center

Kizilcik, Hasan Sahin; Damli, Volkan; Unsal, Yasin

2014-01-01

The aim of this study is to draw attention to the informal education aspect of the movies shown and to determine the awareness levels about physics in movies of a small group composed of university students. That is an evaluation had been made among the films dealing explicitly with the basic content of physics, except for science fiction movies,…

Monitoring global vegetation

NASA Technical Reports Server (NTRS)

Macdonald, R. B.; Houston, A. G.; Heydorn, R. P.; Botkin, D. B.; Estes, J. E.; Strahler, A. H.

1981-01-01

An attempt is made to identify the need for, and the current capability of, a technology which could aid in monitoring the Earth's vegetation resource on a global scale. Vegetation is one of our most critical natural resources, and accurate timely information on its current status and temporal dynamics is essential to understand many basic and applied environmental interrelationships which exist on the small but complex planet Earth.

Southeast Asia Report

DTIC Science & Technology

1987-01-12

bourgeoisie and strictly punish the speculators and black marketers, while using appropriate policies and measures to develop the positive aspects and...allowed to produce and distribute the goods themselves. The commercial bourgeoisie must be eliminated. However, small and medium-sized traders who have...production forces urgently demand new economic thinking. To renovate the party’s economic thinking is to apply the basic principle of Marxism - Leninism

Determining and Meeting Personnel Training Needs

ERIC Educational Resources Information Center

Jennings, Anita

2005-01-01

The role of the library has changed significantly during the past 2 decades. Twenty years ago, it could have been considered the norm for a small to mid-sized library to have one or two computers for patron use. Staff was fortunate to have a computer connected to a printer--a tractor-feed ink jet printer--with a basic word processing application…

The Use of Indigenous Languages in Early Basic Education in Papua New Guinea: A Model for Elsewhere?

ERIC Educational Resources Information Center

Klaus, David

2003-01-01

Suggests Papua New Guinea offers a practical example of how a small, multilingual country with limited resources has developed a package of strategies for dealing with the challenges of multilingualism and using its multiplicity of languages in education as a tool for improving teaching and learning, saving resources, and moving towards education…

Small Business Ownership Management Entrepreneurship. A Model for Vocational Education Program Development in Entrepreneurship.

ERIC Educational Resources Information Center

Arkansas Univ., Fayetteville.

This guide for instruction in the basics of entrepreneurship is intended for use in adult education programs, and secondary and postsecondary business education programs. It can be used as integrative material for all vocational-technical programs as well, since it provides a beginning point for those who are interested in self-employment and for…

Low Reynolds Number Vehicles

DTIC Science & Technology

1985-02-01

numbers. At high altitudes aircraft gas turbine engine fan, compressor, and turbine blades with their small chords encounter Reynolds numhers...light man-carrying/man-powered aircraft , minl-RPVs at low altitude, and wind turbines . Since the airfoil section forms the basic element in the...Wind turbine blades also require high aerodynamic efficiency and all-weather capabilities. The need for efficient low Reynolds number airfoils which

Kibbutz Zafone--Big City U.S.A.: Thoughts on Parent-School-Child Interactions

ERIC Educational Resources Information Center

Goldman, Richard; Champagne, David

1975-01-01

A discussion of a small community in northern Israel which asserts that a basic difference between kibbutz and a city is a total integration on the kibbutz of work, education, leisure, and living missing in most urban areas where parents must travel to work; several processes by which increased integration between parents' work and childrens'…

Smartphones: Powerful Tools for Geoscience Education

NASA Astrophysics Data System (ADS)

Johnson, Zackary I.; Johnston, David W.

2013-11-01

Observation, formation of explanatory hypotheses, and testing of ideas together form the basic pillars of much science. Consequently, science education has often focused on the presentation of facts and theories to teach concepts. To a great degree, libraries and universities have been the historical repositories of scientific information, often restricting access to a small segment of society and severely limiting broad-scale geoscience education.

The Black-White Test Score Gap through Third Grade. NBER Working Paper No. 11049

ERIC Educational Resources Information Center

Fryer, Roland G.; Levitt, Steven D.

2005-01-01

This paper describes basic facts regarding the black-white test score gap over the first four years of school. Black children enter school substantially behind their white counterparts in reading and math, but including a small number of covariates erases the gap. Over the first four years of school, however, blacks lose substantial ground…

Implications of Biomedical Technology. Harvard University Program on Technology and Society; Research Review Number One.

ERIC Educational Resources Information Center

Taviss, Irene, Ed.; Koivumaki, Judith, Ed.

A small number of books and articles devoted to the social, political, ethical, and legal implications of the biomedical field and technology have been abstracted for this document. A basic criterion for selection was the focus on questions of overall organization and public policy rather than on more specialized concerns. Topics covered include…

A STUDY OF DROPOUTS FROM ADULT LITERACY PROGRAMS.

ERIC Educational Resources Information Center

NICHOLSON, EUNICE; OTTO, WAYNE

THE FACTORS WHICH MIGHT HAVE CAUSED ADULTS TO DROP OUT OF AN ADULT BASIC EDUCATION PROGRAM WERE EXAMINED. THIS ADULT PROGRAM WAS CONDUCTED IN A SMALL CITY IN WISCONSIN FROM JANUARY TO JUNE, 1966. TWO TEACHERS, A READING TEACHER AND AN ENGLISH TEACHER, HELD CLASS TWICE A WEEK FOR 50 SESSIONS. THIRTY-EIGHT ADULTS RANGING IN AGE FROM 18 TO 60 WERE…

A Manual for Trainers of Small Scale Beekeeping Development Workers.

ERIC Educational Resources Information Center

Gentry, Curtis; And Others

This manual is intended to serve as a guide for those who are helping future Peace Corps Volunteers to acquire basic beekeeping skills. Included in the guide are lesson outlines and handouts for use in each of the 52 sessions of the course. Representative topics discussed in the individual sessions are family live-in, training site investigation,…

Experiences with Teaching Basic Statistics in an Introduction to Civil Engineering Class.

ERIC Educational Resources Information Center

Craddock, James N.

Following a widespread national trend, in 1996, a new two-credit hour course titled "Introduction to Civil Engineering" was introduced at Southern Illinois University at Carbondale (SIUC). The class has a one-hour lecture per week, and a two-hour lab or small group session. One reason for the introduction of this class was to provide earlier…

KSC-01pp1075

NASA Image and Video Library

2001-06-05

KENNEDY SPACE CENTER, Fla. -- The High Energy Solar Spectroscopic Imager (HESSI) spacecraft, which will be launched by a Pegasus XL rocket, arrives at the Skid Strip at Cape Canaveral Air Force Station. Part of NASA's Small Explorer Program, HESSI's primary mission is to explore the basic physics of particle acceleration and explosive energy release in solar flares. Launch is scheduled for no earlier than June 14

Virtual Worlds; Real Learning: Design Principles for Engaging Immersive Environments

NASA Technical Reports Server (NTRS)

Wu (u. Sjarpm)

2012-01-01

The EMDT master's program at Full Sail University embarked on a small project to use a virtual environment to teach graduate students. The property used for this project has evolved our several iterations and has yielded some basic design principles and pedagogy for virtual spaces. As a result, students are emerging from the program with a better grasp of future possibilities.

Is the Elimination of Recess in School a Violation of a Child's Basic Human Rights?

ERIC Educational Resources Information Center

Dubroc, Alicia M.

2007-01-01

The elimination of recess in schools across the country is becoming a normal occurrence in many communities, large and small. In each study presented in this content analysis, we find that free time and unstructured play is indeed essential to a child's healthy cognitive development. Article 31 of the United Nations Convention on the Rights of…

Marketing Is Not a Luxury - Marketing Is a Necessity.

PubMed

Price, Sean

2017-10-01

Physicians who work in small practices constantly face a basic marketing question: What's the best way to sell myself and my business to the community? Because few physicians studied business principles, many won't know the answer. That's why the Texas Medical Association is publishing a book titled Marketing Smart: A Guide for Medical Practices.

PANSAT satellite deployment from STS-95 Discovery's payload bay

NASA Image and Video Library

1998-10-30

STS095-E-5040 (30 Oct. 1998) --- PANSAT, a nonrecoverable satellite developed by the Naval Postgraduate School (NPS) in Monterey, California, is deployed from the cargo bay of the Earth-orbiting Space Shuttle Discovery. The small ball-shaped payload is basically a tiny telecommunications satellite. The photo was recorded with an electronic still camera (ESC) at 1:49:13 GMT, Oct. 30.

The Finnish multisource national forest inventory: small-area estimation and map production

Treesearch

Erkki Tomppo

2009-01-01

A driving force motivating development of the multisource national forest inventory (MS-NFI) in connection with the Finnish national forest inventory (NFI) was the desire to obtain forest resource information for smaller areas than is possible using field data only without significantly increasing the cost of the inventory. A basic requirement for the method was that...

Volunteer English as a Second Language Instructional Program for Non-English Speaking Adults. Final Report.

ERIC Educational Resources Information Center

Catholic Social Services, Harrisburg, PA.

The primary goal of a multi-purpose project was to utilize both Literacy Volunteers of America (LVA) and Laubach Literacy Action (LLA) in training volunteers to teach English to refugees. Catholic Social Services trained 163 volunteers who were placed in adult basic education (ABE) classes, small group instruction settings, and one-to-one tutoring…

"At 75 You Don't Expect to Become a Radio Star"

ERIC Educational Resources Information Center

Stanistreet, Paul

2011-01-01

When 75-year-old Margaret Corston saw a poster in her local library advertising a course in basic radio broadcasting skills, she little thought that some 18 months later she would be hosting her own weekly show, with thousands of listeners, on community radio. From small beginnings--her first course was called "First Steps in Radio"--she began to…

Reexamination of the calculation of two-center, two-electron integrals over Slater-type orbitals. II. Neumann expansion of the exchange integrals

NASA Astrophysics Data System (ADS)

Lesiuk, Michał; Moszynski, Robert

2014-12-01

In this paper we consider the calculation of two-center exchange integrals over Slater-type orbitals (STOs). We apply the Neumann expansion of the Coulomb interaction potential and consider calculation of all basic quantities which appear in the resulting expression. Analytical closed-form equations for all auxiliary quantities have already been known but they suffer from large digital erosion when some of the parameters are large or small. We derive two differential equations which are obeyed by the most difficult basic integrals. Taking them as a starting point, useful series expansions for small parameter values or asymptotic expansions for large parameter values are systematically derived. The resulting expansions replace the corresponding analytical expressions when the latter introduce significant cancellations. Additionally, we reconsider numerical integration of some necessary quantities and present a new way to calculate the integrand with a controlled precision. All proposed methods are combined to lead to a general, stable algorithm. We perform extensive numerical tests of the introduced expressions to verify their validity and usefulness. Advances reported here provide methodology to compute two-electron exchange integrals over STOs for a broad range of the nonlinear parameters and large angular momenta.

Advances in pollination ecology from tropical plantation crops.

PubMed

Klein, Alexandra-Maria; Cunningham, Saul A; Bos, Merijn; Steffan-Dewenter, Ingolf

2008-04-01

Although ecologists traditionally focus on natural ecosystems, there is growing awareness that mixed landscapes of managed and unmanaged systems provide a research environment for understanding basic ecological relationships on a large scale. Here, we show how tropical agroforestry systems can be used to develop ideas about the mechanisms that influence species diversity and subsequent biotic interactions at different spatial scales. Our focus is on tropical plantation crops, mainly coffee and cacao, and their pollinators, which are of basic ecological interest as partners in an important mutualistic interaction. We review how insect-mediated pollination services depend on local agroforest and natural habitats in surrounding landscapes. Further, we evaluate the functional significance of pollinator diversity and the explanatory value of species traits, and we provide an intercontinental comparison of pollinator assemblages. We found that optimal pollination success might be best understood as a consequence of niche complementarities among pollinators in landscapes harboring various species. We further show that small cavity-nesting bees and small generalist beetles were especially affected by isolation from forest and that larger-bodied insects in the same landscapes were not similarly affected. We suggest that mixed tropical landscapes with agroforestry systems have great potential for future research on the interactions between plants and pollinators.

Mapping the Gulf of Maine with side-scan sonar: A new bottom-type classification for complex seafloors

USGS Publications Warehouse

Barnhardt, W.A.; Kelley, J.T.; Dickson, S.M.; Belknap, D.F.

1998-01-01

The bedrock-framed seafloor in the northwestern Gulf of Maine is characterized by extreme changes in bathymetric relief and covered with a wide variety of surficial materials. Traditional methods of mapping cannot accurately represent the great heterogeneity of such a glaciated region. A new mapping scheme for complex seafloors, based primarily on the interpretation of side-scan sonar imagery, utilizes four easily recognized units: rock, gravel, sand and mud. In many places, however, the seafloor exhibits a complicated mixture or extremely 'patchy' distribution of the four basic units, which are too small to map individually. Twelve composite units, each a two-component mixture of the basic units, were established to represent this patchiness at a small scale (1:100,000). Using a geographic information system, these and all other available data (seismic profiles, grab samples, submersible dives and cores) were referenced to a common geographic base, superimposed on bathymetric contours and then integrated into surficial geologic maps of the regional inner continental shelf. This digital representation of the seafloor comprises a multidimensional, interactive model complete with explicit attributes (depth, bottom type) that allow for detailed analysis of marine environments.

Penalobo "Castle Rocks" - First approach to valuing this geoforms.

NASA Astrophysics Data System (ADS)

Pinharandas, Carlos; Nobre, José; Gomes, Ana

2013-04-01

The village of Penalobo, located in the municipality of Sabugal (Portugal) is characterized by hercynian granites with interesting geological features, including pegmatite veins and quartz crystals with exotic forms, and presents some steep slopes and plateaus. From the mountainous configuration highlight some more pronounced elevations called "Castle Rocks". Such structures are composed by granites, which present greater fracturing at the top, which leads to the formation of large granite blocks. In less fractured zones it is possible to observe small folds. An excavation existing in one of those elevations allows us to observe a basic rock outcropping with clusters of crystals mottled with circular shape, which are indicative of the presence of late fluid during crystallization. In the zone of contact with the enclosing granite, there are small folds caused by magma intrusion. Those evidences led us to hypothesize that the peaks observed in the area of Penalobo village were due to the intrusion on basic magma. All this framework and geological environment becomes an asset for the scientific, educational and economic development of the region. On the other hand, it has a vital importance in the context of a strategy of forming a geological park, in the point of view of tourism, research and interpretation.

Small Molecule-Induced Allosteric Activation of the Vibrio Cholerae RTX Cysteine Protease Domain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lupardus, P.J.; Shen, A.; Bogyo, M.

2009-05-19

Vibrio cholerae RTX (repeats in toxin) is an actin-disrupting toxin that is autoprocessed by an internal cysteine protease domain (CPD). The RTX CPD is efficiently activated by the eukaryote-specific small molecule inositol hexakisphosphate (InsP{sub 6}), and we present the 2.1 angstrom structure of the RTX CPD in complex with InsP{sub 6}. InsP{sub 6} binds to a conserved basic cleft that is distant from the protease active site. Biochemical and kinetic analyses of CPD mutants indicate that InsP{sub 6} binding induces an allosteric switch that leads to the autoprocessing and intracellular release of toxin-effector domains.

Small-angle X-ray scattering probe of intermolecular interaction in red blood cells

NASA Astrophysics Data System (ADS)

Liu, Guan-Fen; Wang, We-Jia; Xu, Jia-Hua; Dong, Yu-Hui

2015-03-01

With high concentrations of hemoglobin (Hb) in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentration Hb in solution and red blood cells were analyzed by small-angle X-ray scattering. Calculation of the effective structure factor indicates that the interaction of Hb molecules is the same when they are crowded together in both the cell and physiological saline. The Hb molecules stay individual without the formation of aggregates and clusters in cells. Supported by National Basic Research Program of China (2009CB918600) and National Natural Science Foundation of China (10979005)

Flight-Determined, Subsonic, Lateral-Directional Stability and Control Derivatives of the Thrust-Vectoring F-18 High Angle of Attack Research Vehicle (HARV), and Comparisons to the Basic F-18 and Predicted Derivatives

NASA Technical Reports Server (NTRS)

Iliff, Kenneth W.; Wang, Kon-Sheng Charles

1999-01-01

The subsonic, lateral-directional, stability and control derivatives of the thrust-vectoring F-1 8 High Angle of Attack Research Vehicle (HARV) are extracted from flight data using a maximum likelihood parameter identification technique. State noise is accounted for in the identification formulation and is used to model the uncommanded forcing functions caused by unsteady aerodynamics. Preprogrammed maneuvers provided independent control surface inputs, eliminating problems of identifiability related to correlations between the aircraft controls and states. The HARV derivatives are plotted as functions of angles of attack between 10deg and 70deg and compared to flight estimates from the basic F-18 aircraft and to predictions from ground and wind tunnel tests. Unlike maneuvers of the basic F-18 aircraft, the HARV maneuvers were very precise and repeatable, resulting in tightly clustered estimates with small uncertainty levels. Significant differences were found between flight and prediction; however, some of these differences may be attributed to differences in the range of sideslip or input amplitude over which a given derivative was evaluated, and to differences between the HARV external configuration and that of the basic F-18 aircraft, upon which most of the prediction was based. Some HARV derivative fairings have been adjusted using basic F-18 derivatives (with low uncertainties) to help account for differences in variable ranges and the lack of HARV maneuvers at certain angles of attack.

Neuromusculoskeletal models based on the muscle synergy hypothesis for the investigation of adaptive motor control in locomotion via sensory-motor coordination.

PubMed

Aoi, Shinya; Funato, Tetsuro

2016-03-01

Humans and animals walk adaptively in diverse situations by skillfully manipulating their complicated and redundant musculoskeletal systems. From an analysis of measured electromyographic (EMG) data, it appears that despite complicated spatiotemporal properties, muscle activation patterns can be explained by a low dimensional spatiotemporal structure. More specifically, they can be accounted for by the combination of a small number of basic activation patterns. The basic patterns and distribution weights indicate temporal and spatial structures, respectively, and the weights show the muscle sets that are activated synchronously. In addition, various locomotor behaviors have similar low dimensional structures and major differences appear in the basic patterns. These analysis results suggest that neural systems use muscle group combinations to solve motor control redundancy problems (muscle synergy hypothesis) and manipulate those basic patterns to create various locomotor functions. However, it remains unclear how the neural system controls such muscle groups and basic patterns through neuromechanical interactions in order to achieve adaptive locomotor behavior. This paper reviews simulation studies that explored adaptive motor control in locomotion via sensory-motor coordination using neuromusculoskeletal models based on the muscle synergy hypothesis. Herein, the neural mechanism in motor control related to the muscle synergy for adaptive locomotion and a potential muscle synergy analysis method including neuromusculoskeletal modeling for motor impairments and rehabilitation are discussed. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Gustatory sensation of (L)- and (D)-amino acids in humans.

PubMed

Kawai, Misako; Sekine-Hayakawa, Yuki; Okiyama, Atsushi; Ninomiya, Yuzo

2012-12-01

Amino acids are known to elicit complex taste, but most human psychophysical studies on the taste of amino acids have focused on a single basic taste, such as umami (savory) taste, sweetness, or bitterness. In this study, we addressed the potential relationship between the structure and the taste properties of amino acids by measuring the human gustatory intensity and quality in response to aqueous solutions of proteogenic amino acids in comparison to D-enantiomers. Trained subjects tasted aqueous solution of each amino acid and evaluated the intensities of total taste and each basic taste using a category-ratio scale. Each basic taste of amino acids showed the dependency on its hydrophobicity, size, charge, functional groups on the side chain, and chirality of the alpha carbon. In addition, the overall taste of amino acid was found to be the combination of basic tastes according to the partial structure. For example, hydrophilic non-charged middle-sized amino acids elicited sweetness, and L-enantiomeric hydrophilic middle-sized structure was necessary for umami taste. For example, L-serine had mainly sweet and minor umami taste, and D-serine was sweet. We further applied Stevens' psychophysical function to relate the total-taste intensity and the concentration, and found that the slope values depended on the major quality of taste (e.g., bitter large, sour small).

Functions of MicroRNAs in Cardiovascular Biology and Disease

PubMed Central

Hata, Akiko

2015-01-01

In 1993, lin-4 was discovered as a critical modulator of temporal development in Caenorhabditis elegans and, most notably, as the first in the class of small, single-stranded noncoding RNAs now defined as microRNAs (miRNAs). Another eight years elapsed before miRNA expression was detected in mammalian cells. Since then, explosive advancements in the field of miRNA biology have elucidated the basic mechanism of miRNA biogenesis, regulation, and gene-regulatory function. The discovery of this new class of small RNAs has augmented the complexity of gene-regulatory programs as well as the understanding of developmental and pathological processes in the cardiovascular system. Indeed, the contributions of miRNAs in cardiovascular development and function have been widely explored, revealing the extensive role of these small regulatory RNAs in cardiovascular physiology. PMID:23157557

Infrared small target enhancement: grey level mapping based on improved sigmoid transformation and saliency histogram

NASA Astrophysics Data System (ADS)

Wan, Minjie; Gu, Guohua; Qian, Weixian; Ren, Kan; Chen, Qian

2018-06-01

Infrared (IR) small target enhancement plays a significant role in modern infrared search and track (IRST) systems and is the basic technique of target detection and tracking. In this paper, a coarse-to-fine grey level mapping method using improved sigmoid transformation and saliency histogram is designed to enhance IR small targets under different backgrounds. For the stage of rough enhancement, the intensity histogram is modified via an improved sigmoid function so as to narrow the regular intensity range of background as much as possible. For the part of further enhancement, a linear transformation is accomplished based on a saliency histogram constructed by averaging the cumulative saliency values provided by a saliency map. Compared with other typical methods, the presented method can achieve both better visual performances and quantitative evaluations.

[The hormonal and genetic effects induced by an irradiation in small dozes at Tradescantia (a clone 02)].

PubMed

Khomichenko, A A; Skorobogatova, I V; Karsunkina, N P; Zaĭnullin, V G

2007-01-01

The purpose of the present work was studying the possible interrelation of the hormonal status of plants and size of the genetic effects induced by an irradiation in small dozes. The frequency of somatic mutations in strings Tradescantia (a clone 02) at an irradiation in dozes up to 28 cGy was estimated. Influence radiations in a range from background up to 28 cGy on the maintenance in inflorescences Tradescantia (a clone 02) the basic groups of plant hormones is investigated: abscisic acid, cytokinin, auxin and gibberellin A3. It is shown, that small dozes of an irradiation cause extremely radical changes of hormonal balance in fabrics of inflorescences Tradescantia. Received results are discussed with attraction of the data on influence phytohormones on kinetics a cellular cycle.

Commercialization of basic research from within the university and return of value to the public

PubMed Central

Hammerstedt, Roy H; Blach, Edward L

2008-01-01

The responsibility to return “value” to those who support basic research is an obligatory part of accepting funds to support the research. This reality should, but now does not, impact planning and execution of all basic research from its earliest stages. Universities are becoming ever more important in their role in the accelerating quest of a national goal of transition to a “knowledge based economy.” As such, the complex organizational format of a university, laden with entrenched procedures of questionable utility, should be adjusted to identify the means to commercialize the small subset of projects that appear suitable for further development. Of special concern is the growing tendency to encourage academic “innovators” to develop spin-out companies “on the side.” While seductive in perceived simplicity, this is a difficult step and we believe that most such individuals are ill-suited to these activities. Not because of technical ability but because of lack of relevant management experience. We attempt to address that situation through a brief listing of some reasons why people “do research” and outline phases (steps) in moving from concept to application, including an overview of start-up and funding early-stage spin-outs. A discussion of the limits to applying results of basic research to enhancing sperm fertility in commodity and companion animals and humans is provided. Hurdles are so daunting that there is concern as to why anyone would attempt to translate basic observations into practical solutions; which in turn raises the question of why funding agencies should fund basic studies in the first place. PMID:18164880

Tuning the acid/base properties of nanocarbons by functionalization via amination.

PubMed

Arrigo, Rosa; Hävecker, Michael; Wrabetz, Sabine; Blume, Raoul; Lerch, Martin; McGregor, James; Parrott, Edward P J; Zeitler, J Axel; Gladden, Lynn F; Knop-Gericke, Axel; Schlögl, Robert; Su, Dang Sheng

2010-07-21

The surface chemical properties and the electronic properties of vapor grown carbon nanofibers (VGCNFs) have been modified by treatment of the oxidized CNFs with NH(3). The effect of treatment temperature on the types of nitrogen functionalities introduced was evaluated by synchrotron based X-ray photoelectron spectroscopy (XPS), while the impact of the preparation methods on the surface acid-base properties was investigated by potentiometric titration, microcalorimetry, and zeta potential measurements. The impact of the N-functionalization on the electronic properties was measured by THz-Time Domain spectroscopy. The samples functionalized via amination are characterized by the coexistence of acidic and basic O and N sites. The population of O and N species is temperature dependent. In particular, at 873 K nitrogen is stabilized in substitutional positions within the graphitic structure, as heterocyclic-like moieties. The surface presents heterogeneously distributed and energetically different basic sites. A small amount of strong basic sites gives rise to a differential heat of CO(2) adsorption of 150 kJ mol(-1). However, when functionalization is carried out at 473 K, nitrogen moieties with basic character are introduced and the maximum heat of adsorption is significantly lower, at approximately 90 kJ mol(-1). In the latter sample, energetically different basic sites coexist with acidic oxygen groups introduced during the oxidative step. Under these conditions, a bifunctional acidic and basic surface is obtained with high hydrophilic character. N-functionalization carried out at higher temperature changes the electronic properties of the CNFs as evaluated by THz-TDS. The functionalization procedure presented in this work allows high versatility and flexibility in tailoring the surface chemistry of nanocarbon material to specific needs. This work shows the potential of the N-containing nanocarbon materials obtained via amination in catalysis as well as electronic device materials.

Minimizing residual aluminum concentration in treated water by tailoring properties of polyaluminum coagulants.

PubMed

Kimura, Masaoki; Matsui, Yoshihiko; Kondo, Kenta; Ishikawa, Tairyo B; Matsushita, Taku; Shirasaki, Nobutaka

2013-04-15

Aluminum coagulants are widely used in water treatment plants to remove turbidity and dissolved substances. However, because high aluminum concentrations in treated water are associated with increased turbidity and because aluminum exerts undeniable human health effects, its concentration should be controlled in water treatment plants, especially in plants that use aluminum coagulants. In this study, the effect of polyaluminum chloride (PACl) coagulant characteristics on dissolved residual aluminum concentrations after coagulation and filtration was investigated. The dissolved residual aluminum concentrations at a given coagulation pH differed among the PACls tested. Very-high-basicity PACl yielded low dissolved residual aluminum concentrations and higher natural organic matter (NOM) removal. The low residual aluminum concentrations were related to the low content of monomeric aluminum (Ala) in the PACl. Polymeric (Alb)/colloidal (Alc) ratio in PACl did not greatly influence residual aluminum concentration. The presence of sulfate in PACl contributed to lower residual aluminum concentration only when coagulation was performed at around pH 6.5 or lower. At a wide pH range (6.5-8.5), residual aluminum concentrations <0.02 mg/L were attained by tailoring PACl properties (Ala percentage ≤0.5%, basicity ≥85%). The dissolved residual aluminum concentrations did not increase with increasing the dosage of high-basicity PACl, but did increase with increasing the dosage of normal-basicity PACl. We inferred that increasing the basicity of PACl afforded lower dissolved residual aluminum concentrations partly because the high-basicity PACls could have a small percentage of Ala, which tends to form soluble aluminum-NOM complexes with molecular weights of 100 kDa-0.45 μm. Copyright © 2013 Elsevier Ltd. All rights reserved.

The role of simulated small-scale ocean variability in inverse computations for ocean acoustic tomography.

PubMed

Dushaw, Brian D; Sagen, Hanne

2017-12-01

Ocean acoustic tomography depends on a suitable reference ocean environment with which to set the basic parameters of the inverse problem. Some inverse problems may require a reference ocean that includes the small-scale variations from internal waves, small mesoscale, or spice. Tomographic inversions that employ data of stable shadow zone arrivals, such as those that have been observed in the North Pacific and Canary Basin, are an example. Estimating temperature from the unique acoustic data that have been obtained in Fram Strait is another example. The addition of small-scale variability to augment a smooth reference ocean is essential to understanding the acoustic forward problem in these cases. Rather than a hindrance, the stochastic influences of the small scale can be exploited to obtain accurate inverse estimates. Inverse solutions are readily obtained, and they give computed arrival patterns that matched the observations. The approach is not ad hoc, but universal, and it has allowed inverse estimates for ocean temperature variations in Fram Strait to be readily computed on several acoustic paths for which tomographic data were obtained.

First micro-satellite and new enhanced small satellite series in DFH Satellite Co. Ltd.

NASA Astrophysics Data System (ADS)

Zhang, Xiaomin; Xie, Bin; Dai, Shoulun; Zhang, Weiwen; Hu, Gefeng; Lan, Ding

2007-06-01

As one important department of CAST (Chinese Academy of Space Technology), with responsibility for small and micro-satellite development, DFH Satellite Co. Ltd. (DFHSat) manufactured and launched six small satellites from 2000 to 2004. Nowadays, DFHSat is developing micro-satellite and new enhanced small satellite series. The first micro-satellite as a basic type is named HummerSat-1. HummerSat-1 is three-axis stabilized with orbit control capability. Information and power control are implemented through an on-board network, GaAs solar cell and Li-ion battery are adopted to obtain and storage power, S-band TT&C and data transmission works are used. The payload of HummerSat-1 has a weight of 60 kg and power consumption of 200 W. The enhanced small satellite series based on technology of HummerSat-1 is planned by DFHSat. It would be aiming to form a continuative product spectrum of 80-200 kg. The enhanced series is focused on satisfying different missions, including earth remote sensing, communication, science exploration, etc.

[Understanding the symbolic values of Japanese onomatopoeia: comparison of Japanese and Chinese speakers].

PubMed

Haryu, Etsuko; Zhao, Lihua

2007-10-01

Do non-native speakers of the Japanese language understand the symbolic values of Japanese onomatopoeia matching a voiced/unvoiced consonant with a big/small sound made by a big/small object? In three experiments, participants who were native speakers of Japanese, Japanese-learning Chinese, or Chinese without knowledge of the Japanese language were shown two pictures. One picture was of a small object making a small sound, such as a small vase being broken, and the other was of a big object making a big sound, such as a big vase being broken. Participants were presented with two novel onomatopoetic words with voicing contrasts, e.g.,/dachan/vs./tachan/, and were told that each word corresponded to one of the two pictures. They were then asked to match the words to the corresponding pictures. Chinese without knowledge of Japanese performed only at chance level, whereas Japanese and Japanese-learning Chinese successfully matched a voiced/unvoiced consonant with a big/small object respectively. The results suggest that the key to understanding the symbolic values of voicing contrasts in Japanese onomatopoeia is some basic knowledge that is intrinsic to the Japanese language.

Prony Ringdown GUI (CERTS Prony Ringdown, part of the DSI Tool Box)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tuffner, Francis; Marinovici, PNNL Laurentiu; Hauer, PNNL John

2014-02-21

The PNNL Prony Ringdown graphical user interface is one analysis tool included in the Dynamic System Identification toolbox (DSI Toolbox). The Dynamic System Identification toolbox is a MATLAB-based collection of tools for parsing and analyzing phasor measurement unit data, especially in regards to small signal stability. It includes tools to read the data, preprocess it, and perform small signal analysis. 5. Method of Solution: The Dynamic System Identification Toolbox (DSI Toolbox) is designed to provide a research environment for examining phasor measurement unit data and performing small signal stability analysis. The software uses a series of text-driven menus to helpmore » guide users and organize the toolbox features. Methods for reading in populate phasor measurement unit data are provided, with appropriate preprocessing options for small-signal-stability analysis. The toolbox includes the Prony Ringdown GUI and basic algorithms to estimate information on oscillatory modes of the system, such as modal frequency and damping ratio.« less

Jovian Small Orbiter for Magnetospheric and Auroral Studies

NASA Astrophysics Data System (ADS)

Takashima, T.; Kasaba, Y.; Misawa, H.; Kawaguchi, J.

2005-12-01

Solar-Sail Project to have been examined by ISAS/JAXA as an engineering mission has a possibility of a small probe into the Jovian orbit. This paper summarizes the basic design of Jovian magnetospheric and auroral studies by this small chance. The large-scale Jovian mission has been a hope since the 1970s when the examinations of planetary exploration were started in Japan. In the one of plans, the largest planet in the solar system would be solved by two main objectives: (1) Structure of a gas planet: the internal & atmospheric structures of a gas planet which could not become a star (following the objectives of Planet-C and BepiColombo). (2) Jovian-type magnetosphere: the process of a pulsar-like magnetosphere with the strongest magnetospheric activities in the solar system (following the objectives of BepiColombo and SCOPE). The small polar-orbit orbiter in Solar-Sail Project aims to establish the feasibility of such future outer planet missions by ISAS/JAXA. It aims the former target in its limited resources.

College Students' Conceptions of Chemical Stability: The Widespread Adoption of a Heuristic Rule out of Context and beyond Its Range of Application

ERIC Educational Resources Information Center

Taber, Keith S.

2009-01-01

This paper reports evidence that learners commonly develop a notion of chemical stability that, whilst drawing upon ideas taught in the curriculum, is nevertheless inconsistent with basic scientific principles. A series of related small-scale studies show that many college-level students consider a chemical species with an octet structure, or a…

Hazardous Waste Site Analysis (Small Site Technology)

DTIC Science & Technology

1990-08-01

Act HSRT - Hazardous Substance Response Trust (Superfund Trust) HSWA - Hdzardeus and Solid Waste Amendments (to RCRA) NAAQSD - National Ambient Air...impoundments (basically, any area where hazardous substances are located). * Under CERCLA, "Environment" includes surface and groundwater, ambient air, land...34 provisions with permit requirements for new source construction). " Ambient Air Quality standards (NAAQs) have been issued for six "criteria" pollutants

Comparing models for growth and management of forest tracts

Treesearch

J.J. Colbert; Michael Schuckers; Desta Fekedulegn

2003-01-01

The Stand Damage Model (SDM) is a PC-based model that is easily installed, calibrated and initialized for use in exploring the future growth and management of forest stands or small wood lots. We compare the basic individual tree growth model incorporated in this model with alternative models that predict the basal area growth of trees. The SDM is a gap-type simulator...

Particle Simulation of Hypersonic Flow

DTIC Science & Technology

1990-04-24

the small volume (this is the same basic concept used in setting up Eq. (2)). Using this interpretation, we can write Eq. (11) as follows zAB dgAt = S...it leads to the expression given by ZAB dgAt = S F(g)dg P, (18) where in this case, we have S nAnB’ (19) 1 + bAB’ and where P, is again given by (17

JPRS Report, Science & Technology. Europe: Economic Competitiveness

DTIC Science & Technology

1991-08-09

cost . Under the current funding scheme, support is only available through a system of reimbursable interest-free loans. With the currently proposed... system , basic indus- trial research will henceforth be financed by subsidies (of up to 50 percent of gross costs ). Small- and medium- sized...extremely cost -effective installations. • To market the MD110 as a foundation for office automation facilities. • To target very large system

Brief Report: Accuracy and Response Time for the Recognition of Facial Emotions in a Large Sample of Children with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Fink, Elian; de Rosnay, Marc; Wierda, Marlies; Koot, Hans M.; Begeer, Sander

2014-01-01

The empirical literature has presented inconsistent evidence for deficits in the recognition of basic emotion expressions in children with autism spectrum disorders (ASD), which may be due to the focus on research with relatively small sample sizes. Additionally, it is proposed that although children with ASD may correctly identify emotion…

Gyroscope relativity experiment

NASA Technical Reports Server (NTRS)

Decher, R.

1971-01-01

A gyroscope test of general relativity theory is proposed. The basic ideas and hardware concepts conceived by the investigators to implement the experiment are discussed. The goal is to measure the extremely small relativistic precession of gyroscopes in an earth-orbiting satellite. The experiment hardware (cryogenic gyroscopes, a telescope and superconducting circuits) is enclosed in a liquid helium dewar. The experiment will operate in orbit for about one year.

Government Support for Synthetic Pipeline Gas Uncertain and Needs Attention.

DTIC Science & Technology

1982-05-14

coal gas. Tear Sheetii RECOMMENDATIONS GAO recommends that the Secretary of Energy - --establish a plan to guide future support of high-Btu coal...recognizes that there are basic dif- ferences expected from large and small scale research projects, GAO believes that the report recognizes these...transportation, including the pipeline system. In its price-setting, or ratemaking function, it represents the interests of gas customers, sometimes

Employee Assistance and Skills Enhancement. Project EASE II. Final Report. [Reporting Period: November 1, 1993-July 31, 1995].

ERIC Educational Resources Information Center

Reed, Tipawan Truong-Quang

Project Employment Assistance and Skill Enhancement (EASE II) was an on-the-job literacy and basic skills improvement project for employees of small companies in the metal working industry in the Chicago area. The goal of the project was to improve literacy skills, leading to the improvement of work force productivity targeted to disadvantaged…

Security Engineering Project

DTIC Science & Technology

2015-01-31

from a wireless joystick console broadcasting at 2.4 GHz. Figure 6. GTRI Airborne Unmanned Sensor System As shown in Figure 7 the autopilot has a...generating wind turbines , and video reconnaissance systems on unmanned aerial vehicles (UAVs). The most basic decision problem in designing a...chosen test UAV case was the GTRI Aerial Unmanned Sensor System (GAUSS) aircraft. The GAUSS platform is a small research UAV with a widely used

The Business Education Index 1996. Index of Business Education Articles and Research Studies Compiled from a Selected List of Periodicals Published during the Year 1996. Volume 57.

ERIC Educational Resources Information Center

Noll, Cheryl L., Ed.; Graves, Pat R., Ed.

This index, which was compiled from a selected list of 45 periodicals published in 1996, lists more than 2,000 business education articles and research studies. Articles are listed under the following subject categories and subcategories: basic business (accounting, consumer awareness, economics, entrepreneurship/small business, finance…

JPRS Report, East Europe

DTIC Science & Technology

1989-10-24

protection program the desulfur - ization of flue gas from large and small sources has highest priority. The financial side must also be taken into...party: the communist party must first of all be the party of workers concentrating the best, the most ideo- logically involved members of the class...corre- spond essentially to the social composition of society? Basic logical considerations show what the class which carries out its leading role

Recent Progress in Silicon Mems Oscillators

DTIC Science & Technology

2008-12-01

MEMS oscillator. As shown, a MEMS resonator is connected to an IC. The reference oscillator, which is basically a transimpedance amplifier ...small size), and (3) DC bias voltage required to operate the resonators. As a result, instead of Colpitts or Pierce architecture, a transimpedence ... amplifier is typically used for sustain the oscillation. The frequency of the resonators is determined by both material properties and geometry of

Development of a Teaching Text of Care, Operation, Maintenance and Repair of Air-Cooled Gasoline Engines.

ERIC Educational Resources Information Center

Turner, Howard

Objectives of a 2-volume book developed as a comprehensive reference for teachers and a text for students on small gasoline engines were that it be: (1) organized for teaching, (2) complete in detail, (3) well illustrated, (4) authentic, (5) edited to high school reading level, (6) correlated with basic scientific principles, and (7) evaluated by…

Franchise Index/Profile: A Franchise Evaluation Process. Small Business Management Series No. 35.

ERIC Educational Resources Information Center

Stigelman, C. R.

The book is presented as an aid to those who have decided to invest in, or who are seriously interested in investigating, a franchise opportunity. The material presented is an index of basic information a person should have about a particular franchise to enable him to make a valid determination as to whether or not a specific franchise is the…

Small Scale Irrigation Systems for Peace Corps Volunteers. Appropriate Technologies for Development. Peace Corps Information Collection & Exchange Reprint No. R-10.

ERIC Educational Resources Information Center

Development Planning and Research Associates, Inc., Manhattan, KS.

This manual is intended for use by Peace Corps trainees and volunteers as a resource in gaining understanding and knowledge of basic irrigation principles and practices. To be most useful, the manual should be used during training as a teaching guide and instructional tool. Although it provides useful charts, drawings, structural diagrams, and…

Effects of Humanitarian Aid: A Cuban Case Study

DTIC Science & Technology

2002-09-01

are then supported by statements from American students . Dagoberto Rodriguez , the Director of North American Affairs in the Cuban Foreign Ministry... students through their time in the United States and interaction with Americans. • Basic infrastructure : Small medical clinics with refrigeration units...required allies. These allies were needed to donate, subsidize, trade, or loan material resources and assist with training programs to make Cuba more self

Elastic Domain Wall Waves in Ferroelectric Ceramics and Single Crystals

DTIC Science & Technology

1988-07-01

properties of piezoelectric and electrostrictive types of ferroelectric ceramics and single crystals. This was for the purpose of shedding light on the...effectiveness and general characteristics of fabrication techniques, as well as exploring basic physical mechanisms playing a role in the technology of...routing and processing devices on small ferroelectric wafers, fabricated by simple inexpensive poling and biasing techniques. Such devices ma) be

From School to Tertiary Study: Transition to College and University in Victoria. ACER Research Monograph No. 14.

ERIC Educational Resources Information Center

Elsworth, Gerald; And Others

A study of the transition of students to higher education in Victoria, Australia, is reported based on data supplied by the Victorian Universities Admissions Committee (VUAC), a mail survey of 1,300 applicants in 1980, and a series of extended interviews with a small number of applicants. A basic causal model for enrollment decisions (college…

Timing the Random and Anomalous Arrival of Particles in a Geiger Counter with GPS Devices

ERIC Educational Resources Information Center

Blanco, F.; La Rocca, P.; Riggi, F.; Riggi, S.

2008-01-01

The properties of the arrival time distribution of particles in a detector have been studied by the use of a small Geiger counter, with a GPS device to tag the event time. The experiment is intended to check the basic properties of the random arrival time distribution between successive events and to simulate the investigations carried out by…

An overview of general aviation propulsion research programs at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Willis, E. A.; Strack, W. C.

1981-01-01

The review covers near-term improvements for current-type piston engines, as well as studies and limited corroborative research on several advanced g/a engine concepts, including diesels, small turboprops and both piston and rotary stratified-charge engines. Also described is basic combustion research, cycle modeling and diagnostic instrumentation work that is required to make new engines a reality.

Modeling economic and carbon consequences of a shift to wood-based energy in a rural 'cluster'; a network analysis in southeast Alaska

Treesearch

David Saah; Trista Patterson; Thomas Buchholz; David Ganz; David Albert; Keith Rush

2014-01-01

Integrated ecological and economic solutions are increasingly sought after by communities to provide basic energy needs such as home heating, transport, and electricity, while reducing drivers of and vulnerability to climate change. Small rural communities may require a coordinated approach to overcome the limitations of economies of scale. Low-carbon development...

Active Learning: A Small Group Histology Laboratory Exercise in a Whole Class Setting Utilizing Virtual Slides and Peer Education

ERIC Educational Resources Information Center

Bloodgood, Robert A.

2012-01-01

Histology laboratory instruction is moving away from the sole use of the traditional combination of light microscopes and glass slides in favor of virtual microscopy and virtual slides. At the same time, medical curricula are changing so as to reduce scheduled time for basic science instruction as well as focusing on student-centered learning…

AutoCAD-To-NASTRAN Translator Program

NASA Technical Reports Server (NTRS)

Jones, A.

1989-01-01

Program facilitates creation of finite-element mathematical models from geometric entities. AutoCAD to NASTRAN translator (ACTON) computer program developed to facilitate quick generation of small finite-element mathematical models for use with NASTRAN finite-element modeling program. Reads geometric data of drawing from Data Exchange File (DXF) used in AutoCAD and other PC-based drafting programs. Written in Microsoft Quick-Basic (Version 2.0).

Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diaz, Dolores, E-mail: diaz.dolores@gene.com; Ford, Kevin A.; Hartley, Dylan P.

Several toxicities are clearly driven by free drug concentrations in plasma, such as toxicities related to on-target exaggerated pharmacology or off-target pharmacological activity associated with receptors, enzymes or ion channels. However, there are examples in which organ toxicities appear to correlate better with total drug concentrations in the target tissues, rather than with free drug concentrations in plasma. Here we present a case study in which a small molecule Met inhibitor, GEN-203, with significant liver and bone marrow toxicity in preclinical species was modified with the intention of increasing the safety margin. GEN-203 is a lipophilic weak base as demonstratedmore » by its physicochemical and structural properties: high LogD (distribution coefficient) (4.3) and high measured pKa (7.45) due to the basic amine (N-ethyl-3-fluoro-4-aminopiperidine). The physicochemical properties of GEN-203 were hypothesized to drive the high distribution of this compound to tissues as evidenced by a moderately-high volume of distribution (Vd > 3 l/kg) in mouse and subsequent toxicities of the compound. Specifically, the basicity of GEN-203 was decreased through addition of a second fluorine in the 3-position of the aminopiperidine to yield GEN-890 (N-ethyl-3,3-difluoro-4-aminopiperidine), which decreased the volume of distribution of the compound in mouse (Vd = 1.0 l/kg), decreased its tissue drug concentrations and led to decreased toxicity in mice. This strategy suggests that when toxicity is driven by tissue drug concentrations, optimization of the physicochemical parameters that drive tissue distribution can result in decreased drug concentrations in tissues, resulting in lower toxicity and improved safety margins. -- Highlights: ► Lower pKa for a small molecule: reduced tissue drug levels and toxicity. ► New analysis tools to assess electrostatic effects and ionization are presented. ► Chemical and PK drivers of toxicity can be leveraged to improve safety.« less

Risperidone added to parent training and stimulant medication: effects on attention-deficit/hyperactivity disorder, oppositional defiant disorder, conduct disorder, and peer aggression.

PubMed

Gadow, Kenneth D; Arnold, L Eugene; Molina, Brooke S G; Findling, Robert L; Bukstein, Oscar G; Brown, Nicole V; McNamara, Nora K; Rundberg-Rivera, E Victoria; Li, Xiaobai; Kipp, Heidi L; Schneider, Jayne; Farmer, Cristan A; Baker, Jennifer L; Sprafkin, Joyce; Rice, Robert R; Bangalore, Srihari S; Butter, Eric M; Buchan-Page, Kristin A; Hurt, Elizabeth A; Austin, Adrienne B; Grondhuis, Sabrina N; Aman, Michael G

2014-09-01

In this study, we aimed to expand on our prior research into the relative efficacy of combining parent training, stimulant medication, and placebo (Basic therapy) versus parent training, stimulant, and risperidone (Augmented therapy) by examining treatment effects for attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD) symptoms and peer aggression, symptom-induced impairment, and informant discrepancy. Children (6-12 years of age; N = 168) with severe physical aggression, ADHD, and co-occurring ODD/CD received an open trial of parent training and stimulant medication for 3 weeks. Participants failing to show optimal clinical response were randomly assigned to Basic or Augmented therapy for an additional 6 weeks. Compared with Basic therapy, children receiving Augmented therapy experienced greater reduction in parent-rated ODD severity (p = .002, Cohen's d = 0.27) and peer aggression (p = .02, Cohen's d = 0.32) but not ADHD or CD symptoms. Fewer children receiving Augmented (16%) than Basic (40%) therapy were rated by their parents as impaired by ODD symptoms at week 9/endpoint (p = .008). Teacher ratings indicated greater reduction in ADHD severity (p = .02, Cohen's d = 0.61) with Augmented therapy, but not for ODD or CD symptoms or peer aggression. Although both interventions were associated with marked symptom reduction, a relatively large percentage of children were rated as impaired for at least 1 targeted disorder at week 9/endpoint by parents (Basic 47%; Augmented 27%) and teachers (Basic 48%; Augmented 38%). Augmented therapy was superior to Basic therapy in reducing severity of ADHD and ODD symptoms, peer aggression, and symptom-induced impairment, but clinical improvement was generally context specific, and effect sizes ranged from small to moderate. Clinical trial registration information-Treatment of Severe Childhood Aggression (The TOSCA Study); http://clinicaltrials.gov/; NCT00796302. Copyright © 2014 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

The onset of plasma potential locking

DOE PAGES

Hopkins, Matthew M.; Yee, Benjamin T.; Baalrud, Scott D.; ...

2016-06-22

In this study, we provide insight into the role and impact that a positively biased electrode (anode) has on bulk plasma potential. Using two-dimensional Particle-in-Cell simulations, we investigate the plasma potential as an anode transitions from very small (“probe” mode) to large (“locking” mode). Prior theory provides some guidance on when and how this transition takes place. Initial experimental results are also compared. The simulations demonstrate that as the surface area of the anode is increased transitions in plasma potential and sheath polarity occur, consistent with experimental observations and theoretical predictions. It is expected that understanding this basic plasma behaviormore » will be of interest to basic plasma physics communities, diagnostic developers, and plasma processing devices where control of bulk plasma potential is important.« less

Implementation of real-time ultrasound in a thoracic surgery practice.

PubMed

Coonar, Aman S; Hughes, Jacqueline A; Walker, Susan; dePerrot, Marc; Waddell, Thomas K; Pierre, Andrew F; Darling, Gail E; Johnston, Michael R; Keshavjee, Shaf

2009-05-01

The purpose of this study was to implement real-time transthoracic ultrasound in a thoracic surgery and lung transplant practice. Ultrasound units that are light, small, robust, and portable are now available. Obstacles to use include demarcation issues between specialties, training, and a perception that basic ultrasound may be difficult to use. The experience of implementing this is described. After a training period, 62 studies were performed in 4 months. Patients and clinicians gave positive feedback. The learning time was short, and with ultrasonic guidance, all interventional procedures were successful at the first attempt, without any complications. Basic transthoracic ultrasound was found to be easy to learn and use by thoracic surgeons, fellows, and specialist nurses. Patients were appreciative. Real-time use may have genuine advantages to patient care.

Influence of phosphorus on the tensile stress strain curves in copper

NASA Astrophysics Data System (ADS)

Sandström, Rolf

2016-03-01

Copper canisters are planned to be used for final disposal of spent nuclear fuel in Sweden. The canisters will be exposed to slow plastic straining over extensive periods of time. To be able to predict the mechanical properties a range of basic models have previously been developed for copper with and without phosphorus (Cu-OFP, Cu-OF). Already with the small amount of phosphorus added in the canisters (60 wt. ppm) dramatic improvements in the measured creep strength and the creep ductility are found. The basic models are further developed in the present paper. The influence of phosphorus on slow strain rate tests is analysed. It is shown that the main effect of phosphorus is that it prevents brittle rupture, which is modelled by taking creep cavitation into account.

Conceptual design studies and experiments related to cavity exhaust systems for nuclear light bulb configurations

NASA Technical Reports Server (NTRS)

Kendall, J. S.; Stoeffler, R. C.

1972-01-01

Investigations of various phases of gaseous nuclear rocket technology have been conducted. The principal research efforts have recently been directed toward the closed-cycle, vortex-stabilized nuclear light bulb engine and toward a small-scale fissioning uranium plasma experiment that could be conducted in the Los Alamos Scientific Laboratory's Nuclear Furnace. The engine concept is based on the transfer of energy by thermal radiation from gaseous fissioning uranium, through a transparent wall, to hydrogen propellant. The reference engine configuration is comprised of seven unit cavities, each having its own fuel transparent wall and propellant duct. The basic design of the engine is described. Subsequent studies performed to supplement and investigate the basic design are reported. Summaries of other nuclear light bulb research programs are included.

Evaluation of Clinical Reasoning in Basic Emergencies Using a Script Concordance Test

PubMed Central

Charlin, Bernard; Vanpee, Dominique

2010-01-01

Objectives To develop and assess the reliability of a script concordance test (SCT) to evaluate pharmacy students' clinical reasoning when facing basic emergency situations. Design A first aid course was designed that consisted of 8 weekly instructional sessions (4 on internal medicine, including life threatening situations; 2 on pediatrics; and 2 on trauma) in which the instructor presented case studies in a small-group format. In the first and final sessions of the course, a practice SCT was administered to familiarize students with the test format. Assessment A 66-question SCT examination was administered to the 68 third-year pharmacy students enrolled in the first aid course. The students' mean score was 68.5% ± 9.8% and panel members' mean score was 86.5% ± 4.2%. Twenty students were selected randomly to complete a course survey and 85% indicated they were satisfied with using the SCT. Conclusions A first aid SCT was found to be both a practical and reliable testing instrument for assessing the clinical reasoning of pharmacy students in basic emergency situations. PMID:21436943

Comparative Biology of Aging

PubMed Central

2009-01-01

Virtually, all research on basic mechanisms of aging has used species that are short lived and thus demonstrably unsuccessful at combating basic aging processes. A novel comparative approach would use a diversity of populations and species, focusing on those with particularly long, healthy lives, seeking the causative mechanisms that distinguish them from shorter lived relatives. Species of interest from this perspective include the naked mole rat, a mouse-size rodent that lives up to 30 years in the laboratory, and the little brown bat, which lives up to 34 years in the wild. Comparisons among dogs of different sizes, which differ by more than 50% in health span might also prove rewarding, as might novel species chosen because of their similarity to humans in certain key traits. Primates, because of their sophisticated cognitive ability, are a group of special value, and small, short-lived primates like the common marmoset might prove especially beneficial. Cell repositories and tissue banks from key species, as well as genomic and analytic tools optimized for comparative studies, would make valuable contributions to a new comparative approach to basic aging research. PMID:19223603

Ultrasensitive response motifs: basic amplifiers in molecular signalling networks

PubMed Central

Zhang, Qiang; Bhattacharya, Sudin; Andersen, Melvin E.

2013-01-01

Multi-component signal transduction pathways and gene regulatory circuits underpin integrated cellular responses to perturbations. A recurring set of network motifs serve as the basic building blocks of these molecular signalling networks. This review focuses on ultrasensitive response motifs (URMs) that amplify small percentage changes in the input signal into larger percentage changes in the output response. URMs generally possess a sigmoid input–output relationship that is steeper than the Michaelis–Menten type of response and is often approximated by the Hill function. Six types of URMs can be commonly found in intracellular molecular networks and each has a distinct kinetic mechanism for signal amplification. These URMs are: (i) positive cooperative binding, (ii) homo-multimerization, (iii) multistep signalling, (iv) molecular titration, (v) zero-order covalent modification cycle and (vi) positive feedback. Multiple URMs can be combined to generate highly switch-like responses. Serving as basic signal amplifiers, these URMs are essential for molecular circuits to produce complex nonlinear dynamics, including multistability, robust adaptation and oscillation. These dynamic properties are in turn responsible for higher-level cellular behaviours, such as cell fate determination, homeostasis and biological rhythm. PMID:23615029

Basic space payload fastener

NASA Technical Reports Server (NTRS)

Vranish, J. M.; Gorevan, Stephen

1995-01-01

A new basic space fastener has been developed and tested by the GSFC. The purposes of this fastener are to permit assembly and servicing in space by astronauts and/or robots and to facilitate qualification of payloads on Earth prior to launch by saving time and money during the systems integration and component testing and qualification processes. The space fastener is a rework of the basic machine screw such that crossthreading is impossible; it is self-locking and will not work its way out during launch (vibration proof); it will not wear out despite repeated use; it occupies a small foot print which is comparable to its machine screw equivalent, and it provides force and exhibits strength comparable to its machine screw equivalent. Construction is ultra-simple and cost effective and the principle is applicable across the full range of screw sizes ranging from a #10 screw to 2.5 cm (1 in) or more. In this paper, the fastener principles of operation will be discussed along with test results and construction details. The new fastener also has considerable potential in the commercial sector. A few promising applications will be presented.

``Physics with a Smile''-Explaining Phenomena with a Qualitative Problem-Solving Strategy

NASA Astrophysics Data System (ADS)

Mualem, Roni; Eylon, Bat-Sheva

2007-03-01

Various studies indicate that high school physics students and even college students majoring in physics have difficulties in qualitative understanding of basic concepts and principles of physics.1-5 For example, studies carried out with the Force Concept Inventory (FCI)1,6 illustrate that qualitative tasks are not easy to solve even at the college level. Consequently, "conceptual physics" courses have been designed to foster qualitative understanding, and advanced high school physics courses as well as introductory college-level courses strive to develop qualitative understanding. Many physics education researchers emphasize the importance of acquiring some qualitative understanding of basic concepts in physics as early as middle school or in the context of courses that offer "Physics First" in the ninth grade before biology or chemistry.7 This trend is consistent with the call to focus the science curriculum on a small number of basic concepts and ideas, and to instruct students in a more "meaningful way" leading to better understanding. Studies7-10 suggest that familiar everyday contexts (see Fig. 1) are useful in fostering qualitative understanding.

Global Security, Medical Isotopes, and Nuclear Science

NASA Astrophysics Data System (ADS)

Ahle, Larry

2007-10-01

Over the past century basic nuclear science research has led to the use of radioactive isotopes into a wide variety of applications that touch our lives everyday. Some are obvious, such as isotopes for medical diagnostics and treatment. Others are less so, such as National/Global security issues. And some we take for granted, like the small amount of 241 Am that is in every smoke detector. At the beginning of this century, we are in a position where the prevalence and importance of some applications of nuclear science are pushing the basic nuclear science community for improved models and nuclear data. Yet, at the same time, the push by the basic nuclear science community to study nuclei that are farther and farther away from stability also offer new opportunities for many applications. This talk will look at several global security applications of nuclear science, summarizing current R&D and need for improved nuclear data It will also look at how applications of nuclear science, such as to medicine, will benefit from the push for more and more powerful radioactive ion beam facilities.

Agreement Between Institutional Measurements and Treatment Planning System Calculations for Basic Dosimetric Parameters as Measured by the Imaging and Radiation Oncology Core-Houston

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerns, James R.; Followill, David S.; Imaging and Radiation Oncology Core-Houston, The University of Texas Health Science Center-Houston, Houston, Texas

Purpose: To compare radiation machine measurement data collected by the Imaging and Radiation Oncology Core at Houston (IROC-H) with institutional treatment planning system (TPS) values, to identify parameters with large differences in agreement; the findings will help institutions focus their efforts to improve the accuracy of their TPS models. Methods and Materials: Between 2000 and 2014, IROC-H visited more than 250 institutions and conducted independent measurements of machine dosimetric data points, including percentage depth dose, output factors, off-axis factors, multileaf collimator small fields, and wedge data. We compared these data with the institutional TPS values for the same points bymore » energy, class, and parameter to identify differences and similarities using criteria involving both the medians and standard deviations for Varian linear accelerators. Distributions of differences between machine measurements and institutional TPS values were generated for basic dosimetric parameters. Results: On average, intensity modulated radiation therapy–style and stereotactic body radiation therapy–style output factors and upper physical wedge output factors were the most problematic. Percentage depth dose, jaw output factors, and enhanced dynamic wedge output factors agreed best between the IROC-H measurements and the TPS values. Although small differences were shown between 2 common TPS systems, neither was superior to the other. Parameter agreement was constant over time from 2000 to 2014. Conclusions: Differences in basic dosimetric parameters between machine measurements and TPS values vary widely depending on the parameter, although agreement does not seem to vary by TPS and has not changed over time. Intensity modulated radiation therapy–style output factors, stereotactic body radiation therapy–style output factors, and upper physical wedge output factors had the largest disagreement and should be carefully modeled to ensure accuracy.« less

Great IDEAS: Telescopes, Computers, and Education

NASA Astrophysics Data System (ADS)

Nook, M. A.; Williams, D. L.

1999-05-01

Two workshops were developed for k-12 teachers that take advantage of the excitement students esperience when viewing objects through a telescope for the first time and the growth in educational opportunities that the internet has generated. The observational astronomy workshop focused on teaching educators a few basics about naked-eye, binocular, and small telescope observing; while the computers in astronomy education workshop taught teachers to develop simple web sites and permitted them to test astronomy software. The observational astronomy workshop met for three days on the SCSU campus to teach basic celestial motions, several constellations, and the basic operation of small telescopes. The next four nights were spent at Camden State Park in southwest Minnesota learning to locate deep sky objects and preparing public presentations. The final two nights the teachers presented public observing programs at three state parks. Fifty percent of the teachers implemented night observing into their curriculum this past year, and one teacher purchased her own telescope to use with students and to help other teachers in the district. The computers in astronomy workshop introduced the teachers to several commercially available astronomy software packages and taught them the fundamentals of constructing simple web pages. The participants were required to develop astronomy lessons based on one of the software packages or a web site that they developed. Each participant then constructed a web-based lesson plan, student lesson, and teacher's guide for their lesson. These lessons are available at http://enstein.stcloudstate.edu/nook/IDEAS/computers/. Support for this work was provided by NASA through grant numbers ED-90156.01-97A and ED-90157.01-97A from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555.

Ochratoxin A in raisins and currants: basic extraction procedure used in two small marketing surveys of the occurrence and control of the heterogeneity of the toxins in samples.

PubMed

Möller, T E; Nyberg, M

2003-11-01

A basic extraction procedure for analysis of ochratoxin A (OTA) in currants and raisins is described, as well as the occurrence of OTA and a control of heterogeneity of the toxin in samples bought for two small marketing surveys 1999/2000 and 2001/02. Most samples in the surveys were divided into two subsamples that were individually prepared as slurries and analysed separately. The limit of quantification for the method was estimated as 0.1 microg kg(-1) and recoveries of 85, 90 and 115% were achieved in recovery experiments at 10, 5 and 0.1 microg kg(-1), respectively. Of all 118 subsamples analysed in the surveys, 96 (84%) contained ochratoxin A at levels above the quantification level and five samples (4%) contained more than the European Community legislation of 10 microg kg(-1). The OTA concentrations found in the first survey were in the range < 0.1-19.0 microg kg(-1) with a median concentration of 0.9 microg kg(-1). In the 2001/02 study, the range was < 0.1-34.6 microg kg(-1) with a median of 0.2 microg kg(-1). Big differences were often achieved between individual subsamples of the original sample, which indicate a wide heterogeneous distribution of the toxin. Data from the repeatability test as well as recovery experiments from the same slurries showed that preparation of slurries as described here seemed to give a homogeneous and representative sample. The extraction with the basic sodium bicarbonate-methanol mixture used in the surveys gave similar or somewhat higher OTA values on some samples tested in a comparison with a weak phosphoric acid water-methanol extraction mixture.

Voluntary attendance of small-group brainstorming tutoring courses intensify new clerk's "excellence in clinical care": a pilot study.

PubMed

Yang, Ling-Yu; Huang, Chia-Chang; Hsu, Hui-Chi; Yang, Ying-Ying; Chang, Ching-Chi; Chuang, Chiao-Lin; Lee, Wei-Shin; Liang, Jen-Feng; Cheng, Hao Min; Huang, Chin-Chou; Lee, Fa-Yauh; Ho, Shung-Tai; Kirby, Ralph

2017-01-06

Clerkship provides a unique way of transferring the knowledge and skills gathered during medical school's curriculum into real-ward clinical care environment. The annual program evaluation has indicated that the training of clerks in diagnostic and clinical reasoning skills needed to be enhanced. Recently, "clinical excellence" program have been promoted in our institution to augment the excellence in clinical care of new clerks. Current study aims to evaluate whether this pilot program improve the "clinical excellence" of new clerks. In a pilot study, groups of new clerks in years 2013 and 2014 voluntarily attended either a small-group brainstorming course or a didactic classroom tutoring courses as part of their 3-month internal medicine clinical rotation block. A third group of new clerks did not join either of the above courses and this group served as the control group. Pre-block/post-block self-assessment and post-block 5-station mini-Objective Subjective Clinical Examinations (OSCEs) were used to evaluate the effectiveness of these two additional courses that trained diagnostic and clinical reasoning skills. Overtime, the percentages of new clerks that attended voluntarily either the small-group brainstorming or classroom tutoring courses were increased. Higher post-block self-assessed diagnostic and clinical reasoning skill scores were found among individuals who attended the small-group brainstorming courses compared to either the didactic group or the control group. In a corresponding manner, the small-group brainstorming group obtained higher summary OSCE diag and OSCE reason scores than either the didactic group or control group. For all basic images/laboratory OSCE stations, the individual diagnostic skill (OSCE diag ) scores of the small-group brainstorming group were higher than those of the didactic group. By way of contrast, only the clinical reasoning skill (OSCE reason ) scores of the basic electrocardiogram and complete blood count + biochemistry OSCE station of thesmall-group brainstorming group were higher than those of the didactic group. Among the small-group brainstorming group, clerks with higher cumulative learning hours (>30-h) had significant higher OSCE diag and OSCE reason scores (>400) than those with less cumulative learning hours. Our pilot study provides a successful example of the use of a small-group tutoring courses for augmenting the diagnostic and clinical reasoning skills of new clerks. The positive results obtained during the initial 2-year long pilot "clinical excellence" program have encouraged the formal implementation of this course as part of the clerkship curriculum.

Small white matter lesion detection in cerebral small vessel disease

NASA Astrophysics Data System (ADS)

Ghafoorian, Mohsen; Karssemeijer, Nico; van Uden, Inge; de Leeuw, Frank E.; Heskes, Tom; Marchiori, Elena; Platel, Bram

2015-03-01

Cerebral small vessel disease (SVD) is a common finding on magnetic resonance images of elderly people. White matter lesions (WML) are important markers for not only the small vessel disease, but also neuro-degenerative diseases including multiple sclerosis, Alzheimer's disease and vascular dementia. Volumetric measurements such as the "total lesion load", have been studied and related to these diseases. With respect to SVD we conjecture that small lesions are important, as they have been observed to grow over time and they form the majority of lesions in number. To study these small lesions they need to be annotated, which is a complex and time-consuming task. Existing (semi) automatic methods have been aimed at volumetric measurements and large lesions, and are not suitable for the detection of small lesions. In this research we established a supervised voxel classification CAD system, optimized and trained to exclusively detect small WMLs. To achieve this, several preprocessing steps were taken, which included a robust standardization of subject intensities to reduce inter-subject intensity variability as much as possible. A number of features that were found to be well identifying small lesions were calculated including multimodal intensities, tissue probabilities, several features for accurate location description, a number of second order derivative features as well as multi-scale annular filter for blobness detection. Only small lesions were used to learn the target concept via Adaboost using random forests as its basic classifiers. Finally the results were evaluated using Free-response receiver operating characteristic.

Hybrid Rocket Experiment Station for Capstone Design

NASA Technical Reports Server (NTRS)

Conley, Edgar; Hull, Bethanne J.

2012-01-01

Portable hybrid rocket motors and test stands can be seen in many papers but none have been reported on the design or instrumentation at such a small magnitude. The design of this hybrid rocket and test stand is to be small and portable (suitcase size). This basic apparatus will be used for demonstrations in rocket propulsion. The design had to include all of the needed hardware to operate the hybrid rocket unit (with the exception of the external Oxygen tank). The design of this project includes making the correlation between the rocket's thrust and its size, the appropriate transducers (physical size, resolution, range, and cost), compatability with a laptop analog card, the ease of setup, and its portability.

A study of Minnesota's high-risk health insurance pool.

PubMed

Zellner, B B; Haugen, D K; Dowd, B

1993-01-01

This is a report of a study of Minnesota's high-risk health insurance pool for "medically uninsurable" persons. The study consisted of a survey of current and past enrollees carried out in the Spring of 1990 and an analysis of the claims and membership files for 1988 and 1989. The main policy conclusion we reached is that Minnesota's high-risk pool is an adequate approach to the problem raised by risk segmentation on the basis of health status, providing that enrollment remains a small fraction of the population. The recent high, enrollment growth rates the Minnesota risk pool has experienced raise the possibility that basic structural reforms of the nongroup and small-group health insurance markets are needed.

A large-scale deforestation experiment: Effects of patch area and isolation on Amazon birds

USGS Publications Warehouse

Ferraz, G.; Nichols, J.D.; Hines, J.E.; Stouffer, P.C.; Bierregaard, R.O.; Lovejoy, T.E.

2007-01-01

As compared with extensive contiguous areas, small isolated habitat patches lack many species. Some species disappear after isolation; others are rarely found in any small patch, regardless of isolation. We used a 13-year data set of bird captures from a large landscape-manipulation experiment in a Brazilian Amazon forest to model the extinction-colonization dynamics of 55 species and tested basic predictions of island biogeography and metapopulation theory. From our models, we derived two metrics of species vulnerability to changes in isolation and patch area. We found a strong effect of area and a variable effect of isolation on the predicted patch occupancy by birds.

Interactions Between Nutrition and Infections With Haemonchus contortus and Related Gastrointestinal Nematodes in Small Ruminants.

PubMed

Hoste, H; Torres-Acosta, J F J; Quijada, J; Chan-Perez, I; Dakheel, M M; Kommuru, D S; Mueller-Harvey, I; Terrill, T H

2016-01-01

Interactions between host nutrition and feeding behaviour are central to understanding the pathophysiological consequences of infections of the digestive tract with parasitic nematodes. The manipulation of host nutrition provides useful options to control gastrointestinal nematodes as a component of an integrated strategy. Focussed mainly on the Haemonchus contortus infection model in small ruminants, this chapter (1) illustrates the relationship between quantitative (macro- and micro-nutrients) and qualitative (plant secondary metabolites) aspects of host nutrition and nematode infection, and (2) shows how basic studies aimed at addressing some generic questions can help to provide solutions, despite the considerable diversity of epidemiological situations and breeding systems. Copyright © 2016 Elsevier Ltd. All rights reserved.

Solitary waves and double layers in a dusty electronegative plasma.

PubMed

Mamun, A A; Shukla, P K; Eliasson, B

2009-10-01

A dusty electronegative plasma containing Boltzmann electrons, Boltzmann negative ions, cold mobile positive ions, and negatively charged stationary dust has been considered. The basic features of arbitrary amplitude solitary waves (SWs) and double layers (DLs), which have been found to exist in such a dusty electronegative plasma, have been investigated by the pseudopotential method. The small amplitude limit has also been considered in order to study the small amplitude SWs and DLs analytically. It has been shown that under certain conditions, DLs do not exist, which is in good agreement with the experimental observations of Ghim and Hershkowitz [Y. Ghim (Kim) and N. Hershkowitz, Appl. Phys. Lett. 94, 151503 (2009)].

Overview of NASA's Pulsed Plasma Thruster Development Program

NASA Technical Reports Server (NTRS)

Pencil, Eric J.; Kamhawi, Hani; Arrington, Lynn A.

2004-01-01

NASA's Pulsed Plasma Thruster Program consists of flight demonstration experiments, base research, and development efforts being conducted through a combination of in-house work, contracts, and collaborative programs. The program receives sponsorship from Energetics Project, the New Millennium Program, and the Small Business Innovative Research Program. The Energetics Project sponsors basic and fundamental research to increase thruster life, improve thruster performance, and reduce system mass. The New Millennium Program sponsors the in-orbit operation of the Pulsed Plasma Thruster experiment on the Earth Observing 1 spacecraft. The Small Business Innovative Research Program sponsors the development of innovative diamond-film capacitors, piezoelectric ignitors, and advanced fuels. Programmatic background, recent technical accomplishments, and future activities for each programmatic element are provided.

Experience in the United States with public deliberation about health insurance benefits using the small group decision exercise, CHAT.

PubMed

Danis, Marion; Ginsburg, Marjorie; Goold, Susan

2010-01-01

"Choosing Healthplans All Together" (CHAT) is a small group decision exercise designed to give the public a voice in priority setting in the face of unsustainable health care costs. It has been used for research, policy, and teaching purposes. Departments of insurance in various states in the United States have used CHAT to determine public opinion about what should be included in basic health insurance packages for the uninsured. Some municipalities have used it to assess public priorities for direct service delivery to the uninsured. Setting up the exercise requires substantial preparation, but the public finds it simple to use and understand.

Small scale wind tunnel model investigation of hybrid high lift systems combining upper surface blowing with the internally blown flap

NASA Technical Reports Server (NTRS)

Waites, W. L.; Chin, Y. T.

1974-01-01

A small-scale wind tunnel test of a two engine hybrid model with upper surface blowing on a simulated expandable duct internally blown flap was accomplished in a two phase program. The low wing Phase I model utilized 0.126c radius Jacobs/Hurkamp flaps and 0.337c radius Coanda flaps. The high wing Phase II model was utilized for continued studies on the Jacobs/Hurkamp flap. Principal study areas included: basic data both engines operative and with an engine out, control flap utilization, horizontal tail effectiveness, spoiler effectiveness, USB nacelle deflector study and USB/IBF pressure ratio effects.

Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells.

PubMed

Sherman, Sean P; Pyle, April D

2013-01-01

Differentiated cells from human embryonic stem cells (hESCs) provide an unlimited source of cells for use in regenerative medicine. The recent derivation of human induced pluripotent cells (hiPSCs) provides a potential supply of pluripotent cells that avoid immune rejection and could provide patient-tailored therapy. In addition, the use of pluripotent cells for drug screening could enable routine toxicity testing and evaluation of underlying disease mechanisms. However, prior to establishment of patient specific cells for cell therapy it is important to understand the basic regulation of cell fate decisions in hESCs. One critical issue that hinders the use of these cells is the fact that hESCs survive poorly upon dissociation, which limits genetic manipulation because of poor cloning efficiency of individual hESCs, and hampers production of large-scale culture of hESCs. To address the problems associated with poor growth in culture and our lack of understanding of what regulates hESC signaling, we successfully developed a screening platform that allows for large scale screening for small molecules that regulate survival. In this work we developed the first large scale platform for hESC screening using laser scanning cytometry and were able to validate this platform by identifying the pro-survival molecule HA-1077. These small molecules provide targets for both improving our basic understanding of hESC survival as well as a tool to improve our ability to expand and genetically manipulate hESCs for use in regenerative applications.

Design of point-of-care (POC) microfluidic medical diagnostic devices

NASA Astrophysics Data System (ADS)

Leary, James F.

2018-02-01

Design of inexpensive and portable hand-held microfluidic flow/image cytometry devices for initial medical diagnostics at the point of initial patient contact by emergency medical personnel in the field requires careful design in terms of power/weight requirements to allow for realistic portability as a hand-held, point-of-care medical diagnostics device. True portability also requires small micro-pumps for high-throughput capability. Weight/power requirements dictate use of super-bright LEDs and very small silicon photodiodes or nanophotonic sensors that can be powered by batteries. Signal-to-noise characteristics can be greatly improved by appropriately pulsing the LED excitation sources and sampling and subtracting noise in between excitation pulses. The requirements for basic computing, imaging, GPS and basic telecommunications can be simultaneously met by use of smartphone technologies, which become part of the overall device. Software for a user-interface system, limited real-time computing, real-time imaging, and offline data analysis can be accomplished through multi-platform software development systems that are well-suited to a variety of currently available cellphone technologies which already contain all of these capabilities. Microfluidic cytometry requires judicious use of small sample volumes and appropriate statistical sampling by microfluidic cytometry or imaging for adequate statistical significance to permit real-time (typically < 15 minutes) medical decisions for patients at the physician's office or real-time decision making in the field. One or two drops of blood obtained by pin-prick should be able to provide statistically meaningful results for use in making real-time medical decisions without the need for blood fractionation, which is not realistic in the field.

Computational mass spectrometry for small molecules

PubMed Central

2013-01-01

The identification of small molecules from mass spectrometry (MS) data remains a major challenge in the interpretation of MS data. This review covers the computational aspects of identifying small molecules, from the identification of a compound searching a reference spectral library, to the structural elucidation of unknowns. In detail, we describe the basic principles and pitfalls of searching mass spectral reference libraries. Determining the molecular formula of the compound can serve as a basis for subsequent structural elucidation; consequently, we cover different methods for molecular formula identification, focussing on isotope pattern analysis. We then discuss automated methods to deal with mass spectra of compounds that are not present in spectral libraries, and provide an insight into de novo analysis of fragmentation spectra using fragmentation trees. In addition, this review shortly covers the reconstruction of metabolic networks using MS data. Finally, we list available software for different steps of the analysis pipeline. PMID:23453222

Small Engine Component Technology (SECT) study

NASA Technical Reports Server (NTRS)

Larkin, T. R.

1986-01-01

The objective of this study is to identify high payoff technologies for year 2000 small gas turbine engines, and to provide a technology plan to guide research and technology efforts toward revolutionizing the small gas turbine technology base. The goal is to define the required technology to provide a 30 percent reduction in mission fuel burned, to reduce direct operating costs by at least 10 percent, and to provide increased reliability and durability of the gas turbine propulsion system. The baseline established to evaluate the year 2000 technology base was an 8-passenger commercial tilt-rotor aircraft powered by a current technology gas turbine engine. Three basic engine cycles were studied: the simple cycle engine, a waste heat recovery cycle, and a wave rotor engine cycle. For the simple cycle engine, two general arrangements were considered: the traditional concentric spool arrangement and a nonconcentric spool arrangement. Both a regenerative and a recuperative cycle were studied for the waste heat recovery cycle.

Runways at small airports are deteriorating because of deferred maintenance: Action needed by FAA and the Congress

NASA Astrophysics Data System (ADS)

1982-09-01

Runways at many small airports are deteriorating faster than necessary because airport owners--usually local governments--have deferred critical maintenance. The result is damage to the runways' basic structure and a shortened useful life if they are not repaired. Based on GAO's review of 46 airports, studies by others, and the views of FAA officials, deferred maintenance is apparently a longstanding nationwide problem. Lack of funds is cited by airport owners as the primary reason for not performing needed maintenance; however, the Federal Aviation Administration's apathy to bring about satisfactory maintenance is a contributing cause. GAO is recommending actions that FAA can take to help ensure that runways at small airports are properly maintained. The Congress should recognize the airport owners' lack of resources to properly maintain airports when considering future revisions to the Airport Improvement Program.

Advances in Small Animal Imaging Systems

NASA Astrophysics Data System (ADS)

Loudos, George K.

2007-11-01

The rapid growth in genetics and molecular biology combined with the development of techniques for genetically engineering small animals has led to an increased interest in in vivo laboratory animal imaging during the past few years. For this purpose, new instrumentation, data acquisition strategies, and image processing and reconstruction techniques are being developed, researched and evaluated. The aim of this article is to give a short overview of the state of the art technologies for high resolution and high sensitivity molecular imaging techniques, primarily positron emission tomography (PET) and single photon emission computed tomography (SPECT). The basic needs of small animal imaging will be described. The evolution in instrumentation in the past two decades, as well as the commercially available systems will be overviewed. Finally, the new trends in detector technology and preliminary results from challenging applications will be presented. For more details a number of references are provided.

Development of FEB Test Platform for ATLAS New Small Wheel Upgrade

NASA Astrophysics Data System (ADS)

Lu, Houbing; Hu, Kun; Wang, Xu; Li, Feng; Han, Liang; Jin, Ge

2016-10-01

This concept of test platform is based on the test requirements of the front-end board (FEB) which is developed for the phase I upgrade of the small Thin Gap Chamber(sTGC) detector on New Small Wheel(NSW) of ATLAS. The front-end electronics system of sTGC consists of 1,536 FEBs with about 322,000 readout of strips, wires and pads in total. A test platform for FEB with up to 256 channels has been designed to keep the testing efficiency at a controllable level. We present the circuit model architecture of the platform, and its functions and implementation as well. The firmware based on Field Programmable Gate Array (FPGA) and the software based on PC have been developed, and basic test methods have been established. FEB readout measurements have been performed in analog injection from the test platform, which will provide a fast and efficient test method for the production of FEB.

Computer simulations of stimulus dependent state switching in basic circuits of bursting neurons

NASA Astrophysics Data System (ADS)

Rabinovich, Mikhail; Huerta, Ramón; Bazhenov, Maxim; Kozlov, Alexander K.; Abarbanel, Henry D. I.

1998-11-01

We investigate the ability of oscillating neural circuits to switch between different states of oscillation in two basic neural circuits. We model two quite distinct small neural circuits. The first circuit is based on invertebrate central pattern generator (CPG) studies [A. I. Selverston and M. Moulins, The Crustacean Stomatogastric System (Springer-Verlag, Berlin, 1987)] and is composed of two neurons coupled via both gap junction and inhibitory synapses. The second consists of coupled pairs of interconnected thalamocortical relay and thalamic reticular neurons with both inhibitory and excitatory synaptic coupling. The latter is an elementary unit of the thalamic networks passing sensory information to the cerebral cortex [M. Steriade, D. A. McCormick, and T. J. Sejnowski, Science 262, 679 (1993)]. Both circuits have contradictory coupling between symmetric parts. The thalamocortical model has excitatory and inhibitory connections and the CPG has reciprocal inhibitory and electrical coupling. We describe the dynamics of the individual neurons in these circuits by conductance based ordinary differential equations of Hodgkin-Huxley type [J. Physiol. (London) 117, 500 (1952)]. Both model circuits exhibit bistability and hysteresis in a wide region of coupling strengths. The two main modes of behavior are in-phase and out-of-phase oscillations of the symmetric parts of the network. We investigate the response of these circuits, while they are operating in bistable regimes, to externally imposed excitatory spike trains with varying interspike timing and small amplitude pulses. These are meant to represent spike trains received by the basic circuits from sensory neurons. Circuits operating in a bistable region are sensitive to the frequency of these excitatory inputs. Frequency variations lead to changes from in-phase to out-of-phase coordination or vice versa. The signaling information contained in a spike train driving the network can place the circuit into one or another state depending on the interspike interval and this happens within a few spikes. These states are maintained by the basic circuit after the input signal is ended. When a new signal of the correct frequency enters the circuit, it can be switched to another state with the same ease.

Neuropsychological basic deficits in preschoolers at risk for ADHD: a meta-analysis.

PubMed

Pauli-Pott, Ursula; Becker, Katja

2011-06-01

Widely accepted neuropsychological theories on attention deficit hyperactivity disorder (ADHD) assume that the complex symptoms of the disease arise from developmentally preceding neuropsychological basic deficits. These deficits in executive functions and delay aversion are presumed to emerge in the preschool period. The corresponding normative developmental processes include phases of relative stability and rapid change. These non-linear developmental processes might have implications for concurrent and predictive associations between basic deficits and ADHD symptoms. To derive a description of the nature and strength of these associations, a meta-analysis was conducted. It is assumed that weighted mean effect sizes differ between basic deficits and depend on age. The meta-analysis included 25 articles (n=3005 children) in which associations between assessments of basic deficits (i.e. response inhibition, interference control, delay aversion, working memory, flexibility, and vigilance/arousal) in the preschool period and concurrent or subsequent ADHD symptoms or diagnosis of ADHD had been analyzed. For response inhibition and delay aversion, mean effect sizes were of medium to large magnitude while the mean effect size for working memory was small. Meta-regression analyses revealed that effect sizes of delay aversion tasks significantly decreased with increasing age while effect sizes of interference control tasks and Continuous Performance Tests (CPTs) significantly increased. Depending on the normative maturational course of each skill, time windows might exist that allow for a more or less valid assessment of a specific deficit. In future research these time windows might help to describe early developing forms of ADHD and to identify children at risk. Copyright © 2011 Elsevier Ltd. All rights reserved.

22 CFR Appendix A to Part 145 - Clauses for Contracts and Small Purchases Awarded by Recipient

Code of Federal Regulations, 2010 CFR

2010-04-01

... suspected or reported violations to the Department. 4. Contract Work Hours and Safety Standards Act (40 U.S... mechanic and laborer on the basis of a standard work week of 40 hours. Work in excess of the standard work... basic rate of pay for all hours worked in excess of 40 hours in the work week. Section 107 of the Act is...

Recent work on airfoil theory

NASA Technical Reports Server (NTRS)

Prandtl, L

1940-01-01

The basic ideas of a new method for treating the problem of the airfoil are presented, and a review is given of the problems thus far computed for incompressible and supersonic flows. Test results are reported for the airfoil of circular plan form and the results are shown to agree well with the theory. As a supplement, a theory based on the older methods is presented for the rectangular of small aspect ratio.

15 KW Small Turboelectric Power Generation System

DTIC Science & Technology

2006-08-18

1 hour per response, including the time for reviewing instnlctions, searching existing data sources, gathering and maintaining the data needed, and...pressure rise is consistent with data from the baseline compressor and a large body of published diffuser data . Table 1 LTS22 Compressor Preliminary... data on designs of 150 HP, 60 HP, and 5 HP engine size class, and in subsequent engine testing. The design methodology encompasses basic sizing