Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy.

PubMed

Rzuczek, Suzanne G; Southern, Mark R; Disney, Matthew D

2015-12-18

There are many RNA targets in the transcriptome to which small molecule chemical probes and lead therapeutics are desired. However, identifying compounds that bind and modulate RNA function in cellulo is difficult. Although rational design approaches have been developed, they are still in their infancies and leave many RNAs "undruggable". In an effort to develop a small molecule library that is biased for binding RNA, we computationally identified "drug-like" compounds from screening collections that have favorable properties for binding RNA and for suitability as lead drugs. As proof-of-concept, this collection was screened for binding to and modulating the cellular dysfunction of the expanded repeating RNA (r(CUG)(exp)) that causes myotonic dystrophy type 1. Hit compounds bind the target in cellulo, as determined by the target identification approach Competitive Chemical Cross-Linking and Isolation by Pull-down (C-ChemCLIP), and selectively improve several disease-associated defects. The best compounds identified from our 320-member library are more potent in cellulo than compounds identified by high-throughput screening (HTS) campaigns against this RNA. Furthermore, the compound collection has a higher hit rate (9% compared to 0.01-3%), and the bioactive compounds identified are not charged; thus, RNA can be "drugged" with compounds that have favorable pharmacological properties. Finally, this RNA-focused small molecule library may serve as a useful starting point to identify lead "drug-like" chemical probes that affect the biological (dys)function of other RNA targets by direct target engagement.

Expedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing.

PubMed

Frei, Reto; Breitbach, Anthony S; Blackwell, Helen E

2012-05-01

We report the highly efficient syntheses of a series of focused libraries in the small molecule macroarray format using Suzuki-Miyaura and copper-catalyzed azide-alkyne cycloaddition (or "click") reactions. The libraries were based on stilbene and triazole scaffolds, which are known to have a broad range of biological activities, including quorum-sensing (QS) modulation in bacteria. The library products were generated in parallel on the macroarray in extremely short reaction times (~10-20 min) and isolated in excellent purities. Biological testing of one macroarray library post-cleavage (ex situ) revealed several potent agonists of the QS receptor, LuxR, in Vibrio fischeri. These synthetic agonists, in contrast to others that we have reported, were only active in the presence of the native QS signal in V. fischeri, which is suggestive of a different mode of activity. Notably, the results presented herein showcase the ready compatibility of the macroarray platform with chemical reactions that are commonly utilized in small molecule probe and drug discovery today. As such, this work serves to expand the utility of the small molecule macroarray as a rapid and operationally straightforward approach toward the synthesis and screening of bioactive agents.

Improving Instruction at MSU. J.W. Brister Library Monograph Series 7.

ERIC Educational Resources Information Center

Mayo, G. Douglas, Ed.

A program providing small grants to faculty members to carry out promising proposals for instructional improvement was undertaken at Memphis State University in 1974. Herein are included fifteen reports describing projects conducted during the third year of the program, and a report evaluating the small grant program. The reports focus on:…

The interdependence between screening methods and screening libraries.

PubMed

Shelat, Anang A; Guy, R Kiplin

2007-06-01

The most common methods for discovery of chemical compounds capable of manipulating biological function involves some form of screening. The success of such screens is highly dependent on the chemical materials - commonly referred to as libraries - that are assayed. Classic methods for the design of screening libraries have depended on knowledge of target structure and relevant pharmacophores for target focus, and on simple count-based measures to assess other properties. The recent proliferation of two novel screening paradigms, structure-based screening and high-content screening, prompts a profound rethink about the ideal composition of small-molecule screening libraries. We suggest that currently utilized libraries are not optimal for addressing new targets by high-throughput screening, or complex phenotypes by high-content screening.

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N; Hill, D R

1993-04-01

The potential for the hospital library as an accepted patient-focused module is viewed in terms of both the present and the future--or no future--in the introduction to this revised recommended list of 606 books and 143 journals. Predecessors of this list have been intended as selection guides for a small or medium-size library in a hospital or comparable medical facility. Due to rapidly rising prices, the secondary purpose--a basic collection for a consortium of hospital libraries or a network sharing library resources--may eventually become its primary use. Books and journals are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals by an alphabetical title listing. For the first time, a "minimal core collection" consisting of 85 books has been broken out from the 200 asterisked initial purchase books. To purchase the entire collection of books and to pay for the 1993 subscriptions would require about $87,000; the cost of only the asterisked books and journals totals $34,800. The "minimal core list" of books costs $11,600.

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1993-01-01

The potential for the hospital library as an accepted patient-focused module is viewed in terms of both the present and the future--or no future--in the introduction to this revised recommended list of 606 books and 143 journals. Predecessors of this list have been intended as selection guides for a small or medium-size library in a hospital or comparable medical facility. Due to rapidly rising prices, the secondary purpose--a basic collection for a consortium of hospital libraries or a network sharing library resources--may eventually become its primary use. Books and journals are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals by an alphabetical title listing. For the first time, a "minimal core collection" consisting of 85 books has been broken out from the 200 asterisked initial purchase books. To purchase the entire collection of books and to pay for the 1993 subscriptions would require about $87,000; the cost of only the asterisked books and journals totals $34,800. The "minimal core list" of books costs $11,600. PMID:8472001

University of Texas Southwestern Medical Center (UTSW): Lung Cancer Oncogenotype-Selective Drug Target Discovery (Natural Products Focus) | Office of Cancer Genomics

Cancer.gov

The goal of this project is to use small molecules and RNAi to functionally define subtypes of non-small cell lung cancer (NSCLC) using a panel of cell lines prepared and molecularly annotated by Drs. John Minna and Adi Gazdar. Experimental Approaches Lung Cancer Natural Products Screening/Chemical Library Screening

University of Texas Southwestern Medical Center: Lung Cancer Oncogenotype-Selective Drug Target Discovery (Natural Products Focus) | Office of Cancer Genomics

Cancer.gov

The goal of this project is to use small molecules and RNAi to functionally define subtypes of non-small cell lung cancer (NSCLC) using a panel of cell lines prepared and molecularly annotated by Drs. John Minna and Adi Gazdar. Experimental Approaches Lung Cancer Natural Products Screening/Chemical Library Screening

Identification of small molecule inhibitors of cytokinesis and single cell wound repair

PubMed Central

Clark, Andrew G.; Sider, Jenny R.; Verbrugghe, Koen; Fenteany, Gabriel; von Dassow, George; Bement, William M.

2013-01-01

Screening of small molecule libraries offers the potential to identify compounds that inhibit specific biological processes and, ultimately, to identify macromolecules that are important players in such processes. To date, however, most screens of small molecule libraries have focused on identification of compounds that inhibit known proteins or particular steps in a given process, and have emphasized automated primary screens. Here we have used “low tech” in vivo primary screens to identify small molecules that inhibit both cytokinesis and single cell wound repair, two complex cellular processes that possess many common features. The “diversity set”, an ordered array of 1990 compounds available from the National Cancer Institute, was screened in parallel to identify compounds that inhibit cytokinesis in D. excentricus (sand dollar) embryos and single cell wound repair in X. laevis (frog) oocytes. Two small molecules were thus identified: Sph1 and Sph2. Sph1 reduces Rho activation in wound repair and suppresses formation of the spindle midzone during cytokinesis. Sph2 also reduces Rho activation in wound repair and may inhibit cytokinesis by blocking membrane fusion. The results identify two small molecules of interest for analysis of wound repair and cytokinesis, reveal that these processes are more similar than often realized and reveal the potential power of low tech screens of small molecule libraries for analysis of complex cellular processes. PMID:23125193

Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery.

PubMed

Blakskjaer, Peter; Heitner, Tara; Hansen, Nils Jakob Vest

2015-06-01

DNA-encoded small-molecule library (DEL) technology allows vast drug-like small molecule libraries to be efficiently synthesized in a combinatorial fashion and screened in a single tube method for binding, with an assay readout empowered by advances in next generation sequencing technology. This approach has increasingly been applied as a viable technology for the identification of small-molecule modulators to protein targets and as precursors to drugs in the past decade. Several strategies for producing and for screening DELs have been devised by both academic and industrial institutions. This review highlights some of the most significant and recent strategies along with important results. A special focus on the production of high fidelity DEL technologies with the ability to eliminate screening noise and false positives is included: using a DNA junction called the Yoctoreactor, building blocks (BBs) are spatially confined at the center of the junction facilitating both the chemical reaction between BBs and encoding of the synthetic route. A screening method, known as binder trap enrichment, permits DELs to be screened robustly in a homogeneous manner delivering clean data sets and potent hits for even the most challenging targets. Copyright © 2015 Elsevier Ltd. All rights reserved.

The fast azimuthal integration Python library: pyFAI.

PubMed

Ashiotis, Giannis; Deschildre, Aurore; Nawaz, Zubair; Wright, Jonathan P; Karkoulis, Dimitrios; Picca, Frédéric Emmanuel; Kieffer, Jérôme

2015-04-01

pyFAI is an open-source software package designed to perform azimuthal integration and, correspondingly, two-dimensional regrouping on area-detector frames for small- and wide-angle X-ray scattering experiments. It is written in Python (with binary submodules for improved performance), a language widely accepted and used by the scientific community today, which enables users to easily incorporate the pyFAI library into their processing pipeline. This article focuses on recent work, especially the ease of calibration, its accuracy and the execution speed for integration.

Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.

PubMed

Hirai, Go; Sodeoka, Mikiko

2015-05-19

Synthesis of a focused library is an important strategy to create novel modulators of specific classes of proteins. Compounds in a focused library are composed of a common core structure and different diversity structures. In this Account, we describe our design and synthesis of libraries focused on selective inhibitors of protein phosphatases (PPases). We considered that core structures having structural and electronic features similar to those of PPase substrates, phosphate esters, would be a reasonable choice. Therefore, we extracted core structures from natural products already identified as PPase inhibitors. Since many PPases share similar active-site structures, such phosphate-mimicking core structures should interact with many enzymes in the same family, and therefore the choice of diversity structures is pivotal both to increase the binding affinity and to achieve specificity for individual enzymes. Here we present case studies of application of focused libraries to obtain PPase inhibitors, covering the overall process from selection of core structures to identification and evaluation of candidates in the focused libraries. To synthesize a library focused on protein serine-threonine phosphatases (PPs), we chose norcantharidin as a core structure, because norcantharidin dicarboxylate shows a broad inhibition profile toward several PPs. From the resulting focused library, we identified a highly selective PP2B inhibitor, NCA-01. On the other hand, to find inhibitors of dual-specificity protein phosphatases (DSPs), we chose 3-acyltetronic acid extracted from natural product RK-682 as a core structure, because its structure resembles the transition state in the dephosphorylation reaction of DSPs. However, a highly selective inhibitor was not found in the resulting focused library. Furthermore, an inherent drawback of compounds having the highly acidic 3-acyltetronic acid as a core structure is very weak potency in cellulo, probably due to poor cell membrane permeability. Therefore, we next modified the core structure from acidic to neutral by transformation to the enamine derivative and constructed a second-generation focused library (RE derivatives). The resulting compounds showed dramatically improved cell membrane permeability and inhibitory selectivity and included VHR (vaccinia VH1-related)-selective RE12 and CDC25A/B (cell division cycle 25A/B)-selective RE44. These inhibitors act on target enzymes in cellulo and do not generate reactive oxygen species, which is a potential problem with quinoid-type inhibitors of CDC25s. The cellular activity of RE12 was further improved by replacement of the side chain to afford RE176, which showed more potent antiproliferative activity than RE12 against HeLa cells. The dramatic change of inhibitory selectivity obtained by core structure modification from 3-acyltetronic acid to its enamine derivative was associated with a change in the mode of action. Namely, RE derivatives were found to be noncompetitive inhibitors with respect to a small-molecular substrate of CDC25A/B, whereas RK-682 was a competitive inhibitor of VHR. We identified the binding site of RE derivatives on the CDC25A as a pocket adjacent to the active site; this appears to be a promising target site for development of further novel inhibitors of CDC25s.

A Manual for Small Libraries in Alaska. Second Edition.

ERIC Educational Resources Information Center

Kolb, Audrey

This manual is intended as a guide and a resource for staff and volunteers in small public libraries in Alaska. It is for libraries managed by local residents that have not had training in operating and managing a library. Some of the chapters may be useful to other types of libraries, such as a small school library or a church library. The guide…

A credit-card library approach for disrupting protein-protein interactions.

PubMed

Xu, Yang; Shi, Jin; Yamamoto, Noboru; Moss, Jason A; Vogt, Peter K; Janda, Kim D

2006-04-15

Protein-protein interfaces are prominent in many therapeutically important targets. Using small organic molecules to disrupt protein-protein interactions is a current challenge in chemical biology. An important example of protein-protein interactions is provided by the Myc protein, which is frequently deregulated in human cancers. Myc belongs to the family of basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors. It is biologically active only as heterodimer with the bHLH-ZIP protein Max. Herein, we report a new strategy for the disruption of protein-protein interactions that has been corroborated through the design and synthesis of a small parallel library composed of 'credit-card' compounds. These compounds are derived from a planar, aromatic scaffold and functionalized with four points of diversity. From a 285 membered library, several hits were obtained that disrupted the c-Myc-Max interaction and cellular functions of c-Myc. The IC50 values determined for this small focused library for the disruption of Myc-Max dimerization are quite potent, especially since small molecule antagonists of protein-protein interactions are notoriously difficult to find. Furthermore, several of the compounds were active at the cellular level as shown by their biological effects on Myc action in chicken embryo fibroblast assays. In light of our findings, this approach is considered a valuable addition to the armamentarium of new molecules being developed to interact with protein-protein interfaces. Finally, this strategy for disrupting protein-protein interactions should prove applicable to other families of proteins.

Small Public Libraries Can Serve Big. ERIC Digest.

ERIC Educational Resources Information Center

Parry, Norm

Small public libraries can deliver service like big libraries, without sacrificing hometown warmth and charm. By borrowing strategies used by successful small businesses in the private sector, defining goals and exploiting low cost technologies, small public libraries can serve customer wants as well as much larger institutions. Responding to just…

Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4

NASA Astrophysics Data System (ADS)

Evensen, Erik; Joseph-McCarthy, Diane; Weiss, Gregory A.; Schreiber, Stuart L.; Karplus, Martin

2007-07-01

Combinatorial synthesis and large scale screening methods are being used increasingly in drug discovery, particularly for finding novel lead compounds. Although these "random" methods sample larger areas of chemical space than traditional synthetic approaches, only a relatively small percentage of all possible compounds are practically accessible. It is therefore helpful to select regions of chemical space that have greater likelihood of yielding useful leads. When three-dimensional structural data are available for the target molecule this can be achieved by applying structure-based computational design methods to focus the combinatorial library. This is advantageous over the standard usage of computational methods to design a small number of specific novel ligands, because here computation is employed as part of the combinatorial design process and so is required only to determine a propensity for binding of certain chemical moieties in regions of the target molecule. This paper describes the application of the Multiple Copy Simultaneous Search (MCSS) method, an active site mapping and de novo structure-based design tool, to design a focused combinatorial library for the class II MHC protein HLA-DR4. Methods for the synthesizing and screening the computationally designed library are presented; evidence is provided to show that binding was achieved. Although the structure of the protein-ligand complex could not be determined, experimental results including cross-exclusion of a known HLA-DR4 peptide ligand (HA) by a compound from the library. Computational model building suggest that at least one of the ligands designed and identified by the methods described binds in a mode similar to that of native peptides.

Privileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spaces.

PubMed

Kim, Jonghoon; Kim, Heejun; Park, Seung Bum

2014-10-22

In the search for new therapeutic agents for currently incurable diseases, attention has turned to traditionally "undruggable" targets, and collections of drug-like small molecules with high diversity and quality have become a prerequisite for new breakthroughs. To generate such collections, the diversity-oriented synthesis (DOS) strategy was developed, which aims to populate new chemical space with drug-like compounds containing a high degree of molecular diversity. The resulting DOS-derived libraries have been of great value for the discovery of various bioactive small molecules and therapeutic agents, and thus DOS has emerged as an essential tool in chemical biology and drug discovery. However, the key challenge has become how to design and synthesize drug-like small-molecule libraries with improved biological relevancy as well as maximum molecular diversity. This Perspective presents the development of privileged substructure-based DOS (pDOS), an efficient strategy for the construction of polyheterocyclic compound libraries with high biological relevancy. We envisioned the specific interaction of drug-like small molecules with certain biopolymers via the incorporation of privileged substructures into polyheterocyclic core skeletons. The importance of privileged substructures such as benzopyran, pyrimidine, and oxopiperazine in rigid skeletons was clearly demonstrated through the discovery of bioactive small molecules and the subsequent identification of appropriate target biomolecule using a method called "fluorescence difference in two-dimensional gel electrophoresis". Focusing on examples of pDOS-derived bioactive compounds with exceptional specificity, we discuss the capability of privileged structures to serve as chemical "navigators" toward biologically relevant chemical spaces. We also provide an outlook on chemical biology research and drug discovery using biologically relevant compound libraries constructed by pDOS, biology-oriented synthesis, or natural product-inspired DOS.

How To Organize and Operate a Small Library. A Comprehensive Guide to the Organization and Operation of a Small Library for Your School, Church, Law Firm, Business, Hospital, Community, Court, Historical Museum or Association.

ERIC Educational Resources Information Center

Bernhard, Genore H.

A guide is presented for those unfamiliar with library procedures who wish to organize and operate a small library. Following a discussion of the modern library's role, there is detailed information about library boards, librarians, finance, legal problems, policies, equipment, supplies, and book acquisition and processing. Shelving, filing, book…

Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.

PubMed

Usanov, Dmitry L; Chan, Alix I; Maianti, Juan Pablo; Liu, David R

2018-07-01

DNA-encoded libraries have emerged as a widely used resource for the discovery of bioactive small molecules, and offer substantial advantages compared with conventional small-molecule libraries. Here, we have developed and streamlined multiple fundamental aspects of DNA-encoded and DNA-templated library synthesis methodology, including computational identification and experimental validation of a 20 × 20 × 20 × 80 set of orthogonal codons, chemical and computational tools for enhancing the structural diversity and drug-likeness of library members, a highly efficient polymerase-mediated template library assembly strategy, and library isolation and purification methods. We have integrated these improved methods to produce a second-generation DNA-templated library of 256,000 small-molecule macrocycles with improved drug-like physical properties. In vitro selection of this library for insulin-degrading enzyme affinity resulted in novel insulin-degrading enzyme inhibitors, including one of unusual potency and novel macrocycle stereochemistry (IC 50  = 40 nM). Collectively, these developments enable DNA-templated small-molecule libraries to serve as more powerful, accessible, streamlined and cost-effective tools for bioactive small-molecule discovery.

Small but Pristine--Lessons for Small Library Automation.

ERIC Educational Resources Information Center

Clement, Russell; Robertson, Dane

1990-01-01

Compares the more positive library automation experiences of a small public library with those of a large research library. Topics addressed include collection size; computer size and the need for outside control of a data processing center; staff size; selection process for hardware and software; and accountability. (LRW)

Combinatorial chemistry on solid support in the search for central nervous system agents.

PubMed

Zajdel, Paweł; Pawłowski, Maciej; Martinez, Jean; Subra, Gilles

2009-08-01

The advent of combinatorial chemistry was one of the most important developments, that has significantly contributed to the drug discovery process. Within just a few years, its initial concept aimed at production of libraries containing huge number of compounds (thousands to millions), so called screening libraries, has shifted towards preparation of small and medium-sized rationally designed libraries. When applicable, the use of solid supports for the generation of libraries has been a real breakthrough in enhancing productivity. With a limited amount of resin and simple manual workups, the split/mix procedure may generate thousands of bead-tethered compounds. Beads can be chemically or physically encoded to facilitate the identification of a hit after the biological assay. Compartmentalization of solid supports using small reactors like teabags, kans or pellicular discrete supports like Lanterns resulted in powerful sort and combine technologies, relying on codes 'written' on the reactor, and thus reducing the need for automation and improving the number of compounds synthesized. These methods of solid-phase combinatorial chemistry have been recently supported by introduction of solid-supported reagents and scavenger resins. The first part of this review discusses the general premises of combinatorial chemistry and some methods used in the design of primary and focused combinatorial libraries. The aim of the second part is to present combinatorial chemistry methodologies aimed at discovering bioactive compounds acting on diverse GPCR involved in central nervous system disorders.

Automating Media Centers and Small Libraries: A Microcomputer-Based Approach.

ERIC Educational Resources Information Center

Meghabghab, Dania Bilal

Although the general automation process can be applied to most libraries, small libraries and media centers require a customized approach. Using a systematic approach, this guide covers each step and aspect of automation in a small library setting, and combines the principles of automation with field- tested activities. After discussing needs…

Best Small Library in America 2010

ERIC Educational Resources Information Center

Berry, John N., III

2010-01-01

This article features Glen Carbon Centennial Library (GCCL), Illinois, which is named "LJ"'s Best Small Library in America 2010. The attitude of doing whatever it takes to encourage every patron to come back permeates GCCL and is the foundation that makes it a model small library. GCCL delivers much "more than one expects." The…

Automation, Resource Sharing, and the Small Academic Library.

ERIC Educational Resources Information Center

Miller, Arthur H., Jr.

1983-01-01

Discussion of Illinois experiences in library cooperation and computerization (OCLC, Library Computer System, LIBRAS) describes use of library materials, benefits and drawbacks of online networking, experiences at Lake Forest College (Illinois), and six tasks recommended for small academic libraries as preparation for major changes toward…

[Chemical libraries dedicated to protein-protein interactions].

PubMed

Sperandio, Olivier; Villoutreix, Bruno O; Morelli, Xavier; Roche, Philippe

2015-03-01

The identification of complete networks of protein-protein interactions (PPI) within a cell has contributed to major breakthroughs in understanding biological pathways, host-pathogen interactions and cancer development. As a consequence, PPI have emerged as a new class of promising therapeutic targets. However, they are still considered as a challenging class of targets for drug discovery programs. Recent successes have allowed the characterization of structural and physicochemical properties of protein-protein interfaces leading to a better understanding of how they can be disrupted with small molecule compounds. In addition, characterization of the profiles of PPI inhibitors has allowed the development of PPI-focused libraries. In this review, we present the current efforts at developing chemical libraries dedicated to these innovative targets. © 2015 médecine/sciences – Inserm.

CiPerGenesis, A Mutagenesis Approach that Produces Small Libraries of Circularly Permuted Proteins Randomly Opened at a Focused Region: Testing on the Green Fluorescent Protein.

PubMed

Gaytán, Paul; Roldán-Salgado, Abigail; Yáñez, Jorge A; Morales-Arrieta, Sandra; Juárez-González, Víctor R

2018-06-12

Circularly permuted proteins (cpPs) represent a novel type of mutant proteins with original termini that are covalently linked through a peptide connector and opened at any other place of the polypeptide backbone to create new ends. cpPs are finding wide applications in biotechnology because their properties may be quite different from those of the parental protein. However, the actual challenge for the creation of successful cpPs is to identify those peptide bonds that can be broken to create new termini and ensure functional and well-folded cpPs. Herein, we describe CiPerGenesis, a combinatorial mutagenesis approach that uses two oligonucleotide libraries to amplify a circularized gene by PCR, starting and ending from a focused target region. This approach creates small libraries of circularly permuted genes that are easily cloned in the correct direction and frame using two different restriction sites encoded in the oligonucleotides. Once expressed, the protein libraries exhibit a unique sequence diversity, comprising cpPs that exhibit ordinary breakpoints between adjacent amino acids localized at the target region as well as cpPs with new termini containing user-defined truncations and repeats of some amino acids. CiPerGenesis was tested at the lid region G134-H148 of green fluorescent protein (GFP), revealing that the most fluorescent variants were those starting at Leu141 and ending at amino acids Tyr145, Tyr143, Glu142, Leu141, Lys140, and H139. Purification and biochemical characterization of some variants suggested a differential expression, solubility and maturation extent of the mutant proteins as the likely cause for the variability in fluorescence intensity observed in colonies.

Strategic Planning and the Small Public Library: A Case Study.

ERIC Educational Resources Information Center

Barrish, Alan; Carrigan, Dennis

1991-01-01

Discussion of the need for strategic planning in public libraries highlights a case study of a small resort town library, the Crawford Memorial Library, in Monticello, New York. Deciding on specific library roles and planning their implementation are described, and the importance of environment and competition in strategic planning is explained.…

Generation of an arrayed CRISPR-Cas9 library targeting epigenetic regulators: from high-content screens to in vivo assays

PubMed Central

2017-01-01

ABSTRACT The CRISPR-Cas9 system has revolutionized genome engineering, allowing precise modification of DNA in various organisms. The most popular method for conducting CRISPR-based functional screens involves the use of pooled lentiviral libraries in selection screens coupled with next-generation sequencing. Screens employing genome-scale pooled small guide RNA (sgRNA) libraries are demanding, particularly when complex assays are used. Furthermore, pooled libraries are not suitable for microscopy-based high-content screens or for systematic interrogation of protein function. To overcome these limitations and exploit CRISPR-based technologies to comprehensively investigate epigenetic mechanisms, we have generated a focused sgRNA library targeting 450 epigenetic regulators with multiple sgRNAs in human cells. The lentiviral library is available both in an arrayed and pooled format and allows temporally-controlled induction of gene knock-out. Characterization of the library showed high editing activity of most sgRNAs and efficient knock-out at the protein level in polyclonal populations. The sgRNA library can be used for both selection and high-content screens, as well as for targeted investigation of selected proteins without requiring isolation of knock-out clones. Using a variety of functional assays we show that the library is suitable for both in vitro and in vivo applications, representing a unique resource to study epigenetic mechanisms in physiological and pathological conditions. PMID:29327641

Attitudes about OCLC in Small and Medium-Sized Libraries. Illinois Valley Library System OCLC Experimental Project. Report No. 4.

ERIC Educational Resources Information Center

Bills, Linda G.; Wilford, Valerie

A project was conducted from 1980 to 1982 to determine the costs and benefits of OCLC use in 29 small and medium-sized member libraries of the Illinois Valley Library System (IVLS). Academic, school, public, and special libraries participated in the project. Based on written attitude surveys of and interviews with library directors, staff,…

Protocols for the Design of Kinase-focused Compound Libraries.

PubMed

Jacoby, Edgar; Wroblowski, Berthold; Buyck, Christophe; Neefs, Jean-Marc; Meyer, Christophe; Cummings, Maxwell D; van Vlijmen, Herman

2018-05-01

Protocols for the design of kinase-focused compound libraries are presented. Kinase-focused compound libraries can be differentiated based on the design goal. Depending on whether the library should be a discovery library specific for one particular kinase, a general discovery library for multiple distinct kinase projects, or even phenotypic screening, there exists today a variety of in silico methods to design candidate compound libraries. We address the following scenarios: 1) Datamining of SAR databases and kinase focused vendor catalogues; 2) Predictions and virtual screening; 3) Structure-based design of combinatorial kinase inhibitors; 4) Design of covalent kinase inhibitors; 5) Design of macrocyclic kinase inhibitors; and 6) Design of allosteric kinase inhibitors and activators. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Natural product-like virtual libraries: recursive atom-based enumeration.

PubMed

Yu, Melvin J

2011-03-28

A new molecular enumerator is described that allows chemically and architecturally diverse sets of natural product-like and drug-like structures to be generated from a core structure as simple as a single carbon atom or as complex as a polycyclic ring system. Integrated with a rudimentary machine-learning algorithm, the enumerator has the ability to assemble biased virtual libraries enriched in compounds predicted to meet target criteria. The ability to dynamically generate relatively small focused libraries in a recursive manner could reduce the computational time and infrastructure necessary to construct and manage extremely large static libraries. Depending on enumeration conditions, natural product-like structures can be produced with a wide range of heterocyclic and alicyclic ring assemblies. Because natural products represent a proven source of validated structures for identifying and designing new drug candidates, mimicking the structural and topological diversity found in nature with a dynamic set of virtual natural product-like compounds may facilitate the creation of new ideas for novel, biologically relevant lead structures in areas of uncharted chemical space.

Smartphones: Powerful Tools for Geoscience Education

NASA Astrophysics Data System (ADS)

Johnson, Zackary I.; Johnston, David W.

2013-11-01

Observation, formation of explanatory hypotheses, and testing of ideas together form the basic pillars of much science. Consequently, science education has often focused on the presentation of facts and theories to teach concepts. To a great degree, libraries and universities have been the historical repositories of scientific information, often restricting access to a small segment of society and severely limiting broad-scale geoscience education.

Update on Small Modular Reactors Dynamic System Modeling Tool: Web Application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hale, Richard Edward; Cetiner, Sacit M.; Fugate, David L.

Previous reports focused on the development of component and system models as well as end-to-end system models using Modelica and Dymola for two advanced reactor architectures: (1) Advanced Liquid Metal Reactor and (2) fluoride high-temperature reactor (FHR). The focus of this report is the release of the first beta version of the web-based application for model use and collaboration, as well as an update on the FHR model. The web-based application allows novice users to configure end-to-end system models from preconfigured choices to investigate the instrumentation and controls implications of these designs and allows for the collaborative development of individualmore » component models that can be benchmarked against test systems for potential inclusion in the model library. A description of this application is provided along with examples of its use and a listing and discussion of all the models that currently exist in the library.« less

Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries.

PubMed

O'Hagan, Steve; Kell, Douglas B

2018-01-01

Armed with the digital availability of two natural products libraries, amounting to some 195 885 molecular entities, we ask the question of how we can best sample from them to maximize their "representativeness" in smaller and more usable libraries of 96, 384, 1152, and 1920 molecules. The term "representativeness" is intended to include diversity, but for numerical reasons (and the likelihood of being able to perform a QSAR) it is necessary to focus on areas of chemical space that are more highly populated. Encoding chemical structures as fingerprints using the RDKit "patterned" algorithm, we first assess the granularity of the natural products space using a simple clustering algorithm, showing that there are major regions of "denseness" but also a great many very sparsely populated areas. We then apply a "hybrid" hierarchical K-means clustering algorithm to the data to produce more statistically robust clusters from which representative and appropriate numbers of samples may be chosen. There is necessarily again a trade-off between cluster size and cluster number, but within these constraints, libraries containing 384 or 1152 molecules can be found that come from clusters that represent some 18 and 30% of the whole chemical space, with cluster sizes of, respectively, 50 and 27 or above, just about sufficient to perform a QSAR. By using the online availability of molecules via the Molport system (www.molport.com), we are also able to construct (and, for the first time, provide the contents of) a small virtual library of available molecules that provided effective coverage of the chemical space described. Consistent with this, the average molecular similarities of the contents of the libraries developed is considerably smaller than is that of the original libraries. The suggested libraries may have use in molecular or phenotypic screening, including for determining possible transporter substrates. © 2017 The Authors. Biotechnology Journal Published by Wiley-VCH Verlag GmbH & Co. KGaA.

A Multi-User Microcomputer System for Small Libraries.

ERIC Educational Resources Information Center

Leggate, Peter

1988-01-01

Describes the development of Bookshelf, a multi-user microcomputer system for small libraries that uses an integrated software package. The discussion covers the design parameters of the package, which were based on a survey of seven small libraries, and some characteristics of the software. (three notes with references) (CLB)

Toward the Library-Bookstore

ERIC Educational Resources Information Center

Severtson, Susan; Banks, George

1971-01-01

Close collaboration between library and bookstore (or a complete merger of the two) could do much to solve the immediate problems faced by many small colleges with small library collections and limited budgets. (MF)

Use of focus groups in a library's strategic planning process.

PubMed

Higa-Moore, Mori Lou; Bunnett, Brian; Mayo, Helen G; Olney, Cynthia A

2002-01-01

The use of focus groups to determine patron satisfaction with library resources and services is extensive and well established. This article demonstrates how focus groups can also be used to help shape the future direction of a library as part of the strategic planning process. By responding to questions about their long-term library and information needs, focus group participants at the University of Texas Southwestern Medical Center at Dallas Library contributed an abundance of qualitative patron data that was previously lacking from this process. The selection and recruitment of these patrons is discussed along with the line of questioning used in the various focus group sessions. Of special interest is the way the authors utilized these sessions to mobilize and involve the staff in creating the library's strategic plan. This was accomplished not only by having staff members participate in one of the sessions but also by sharing the project's major findings with them and instructing them in how these findings related to the library's future. The authors' experience demonstrates that focus groups are an effective strategic planning tool for libraries and emphasizes the need to share information broadly, if active involvement of the staff is desired in both the development and implementation of the library's strategic plan.

Use of focus groups in a library's strategic planning process

PubMed Central

Higa-Moore, Mori Lou; Bunnett, Brian; Mayo, Helen G.; Olney, Cynthia A.

2002-01-01

The use of focus groups to determine patron satisfaction with library resources and services is extensive and well established. This article demonstrates how focus groups can also be used to help shape the future direction of a library as part of the strategic planning process. By responding to questions about their long-term library and information needs, focus group participants at the University of Texas Southwestern Medical Center at Dallas Library contributed an abundance of qualitative patron data that was previously lacking from this process. The selection and recruitment of these patrons is discussed along with the line of questioning used in the various focus group sessions. Of special interest is the way the authors utilized these sessions to mobilize and involve the staff in creating the library's strategic plan. This was accomplished not only by having staff members participate in one of the sessions but also by sharing the project's major findings with them and instructing them in how these findings related to the library's future. The authors' experience demonstrates that focus groups are an effective strategic planning tool for libraries and emphasizes the need to share information broadly, if active involvement of the staff is desired in both the development and implementation of the library's strategic plan. PMID:11838465

Simple Library Bookkeeping.

ERIC Educational Resources Information Center

Hoffman, Herbert H.

A simple and cheap manual double entry continuous transaction posting system with running balances is developed for bookkeeping by small libraries. A very small library may operate without any system of fiscal control but when a library's budget approaches three figures, some kind of bookkeeping must be introduced. To maintain control over his…

Continuing Education for the Personnel of Small Public Libraries: Program Development at the Iowa State University Library and Its Collection Development/Technical Services Course.

ERIC Educational Resources Information Center

Roughton, Karen G.; Tyckoson, David A.

This report describes the planning, implementation, and evaluation of a coordinated staff development program to offer certified, non-degree credit to non-professional librarians from small public libraries. Developed through the cooperation of the Central Iowa Regional Library and the Iowa State University Library, the program resulted in a plan…

Computer and Network Security in Small Libraries: A Guide for Planning.

ERIC Educational Resources Information Center

Williams, Robert L.

This manual is intended to provide a free resource on essential network security concepts for non-technical managers of small libraries. Managers of other small nonprofit or community organizations will also benefit from it. An introduction defines network security; outlines three goals of network security; discusses why a library should be…

Focus groups for allied health professionals and professions allied to technical services in the NHS--marketing opportunities, lessons learnt and recommendations.

PubMed

Chamberlain, David; Brook, Richard

2011-09-01

Worcestershire Health Libraries provides services to all NHS and social care staff in Worcestershire. Despite intensive marketing, statistics showed low usage of the library service for professions allied to technical services and allied health professionals. To discover why there was low usage of the library services using qualitative techniques and to use focus groups as a marketing opportunity. This article also aims to outline the processes involved in delivering focus groups, the results gained, and the actions taken in response to the results. Focus groups were conducted in two departments, Pathology and Occupational Therapy. The Biochemistry department (part of Pathology) had two focus groups. An additional focus group was conducted for all the Pathology education leads. Occupational Therapy had two meetings, one for hospital based staff, and the other for community staff. Issues centred on registration, inductions, time, library ambience, multi-disciplinary service and resources. The findings raised marketing opportunities and the process identified potential candidates for the role of team knowledge officer, to act as library champions within departments. It also identified areas in which the library service was not meeting user needs and expectations, and helped focus service development. Focus groups allowed an opportunity to speak to non-users face to face and to discover, and where appropriate challenge both their, and library staff's pre-conceived ideas about the service. The information revealed gave an opportunity to market services based on user needs. © 2011 The authors. Health Information and Libraries Journal © 2011 Health Libraries Group.

Total Library Computerization, Version 2: A DOS-Based Program from On Point, Inc., for Managing Small to Midsized Libraries.

ERIC Educational Resources Information Center

Combs, Joseph, Jr.

1995-01-01

Reviews the Total Library Computerization program, which can be used to manage small to midsized libraries. Discusses costs; operating system requirements; security features; user-interface styles; and system modules including online cataloging, circulation, serials control, acquisitions, authorities control, and interlibrary loan. (Author/JMV)

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N; Hill, D R

1979-04-01

This revised list of 492 books and 138 journals is intended as a selection guide for small or medium-sized hospital libraries or for the small medical library serving a specified clientele. It can also be used as a core list by small hospital library consortia. Books and journals are categorized by subject, with the books being followed by an author index and the journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries are indicated by an asterisk. To purchase the entire collection of books and to pay for annual subscriptions to all the journals would require an expenditure of about $22,500. The cost of only the asterisked items, recommended for first purchase, totals approximately $6,100.

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N

1977-04-01

This revised list of 472 books and 138 journals is intended as a selection guide for small or medium-sized hospital libraries or for the small medical library serving a specified clientele. It can also be used as a core list by small hospital library consortia. Books and journals are categorized by subject, with the books being followed by an author index and the journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries are indicated by an asterisk. To purchase the entire collection of books and to pay for annual subscriptions to all the journals would require an expenditure of about $18,200. The cost of only the asterisked items recommended for first purchase totals approximately $4,500.

BASKET on-board software library

NASA Astrophysics Data System (ADS)

Luntzer, Armin; Ottensamer, Roland; Kerschbaum, Franz

2014-07-01

The University of Vienna is a provider of on-board data processing software with focus on data compression, such as used on board the highly successful Herschel/PACS instrument, as well as in the small BRITE-Constellation fleet of cube-sats. Current contributions are made to CHEOPS, SAFARI and PLATO. The effort was taken to review the various functions developed for Herschel and provide a consolidated software library to facilitate the work for future missions. This library is a shopping basket of algorithms. Its contents are separated into four classes: auxiliary functions (e.g. circular buffers), preprocessing functions (e.g. for calibration), lossless data compression (arithmetic or Rice coding) and lossy reduction steps (ramp fitting etc.). The "BASKET" has all functionality that is needed to create an on-board data processing chain. All sources are written in C, supplemented by optimized versions in assembly, targeting popular CPU architectures for space applications. BASKET is open source and constantly growing

Small Business and the Public Library: Strategies for a Successful Partnership

ERIC Educational Resources Information Center

Weiss, Luise; Serlis-McPhillips, Sophia; Malafi, Elizabeth

2011-01-01

Aligning with current difficult economic times, this book helps libraries assist users entering or already involved in the small business community. Authors Weiss, Serlis-McPhillips, and Malafi are public librarians who have incorporated small business services within their library. In their book they point the way to addressing the needs of job…

A Prospective Virtual Screening Study: Enriching Hit Rates and Designing Focus Libraries To Find Inhibitors of PI3Kδ and PI3Kγ.

PubMed

Damm-Ganamet, Kelly L; Bembenek, Scott D; Venable, Jennifer W; Castro, Glenda G; Mangelschots, Lieve; Peeters, Daniëlle C G; Mcallister, Heather M; Edwards, James P; Disepio, Daniel; Mirzadegan, Taraneh

2016-05-12

Here, we report a high-throughput virtual screening (HTVS) study using phosphoinositide 3-kinase (both PI3Kγ and PI3Kδ). Our initial HTVS results of the Janssen corporate database identified small focused libraries with hit rates at 50% inhibition showing a 50-fold increase over those from a HTS (high-throughput screen). Further, applying constraints based on "chemically intuitive" hydrogen bonds and/or positional requirements resulted in a substantial improvement in the hit rates (versus no constraints) and reduced docking time. While we find that docking scoring functions are not capable of providing a reliable relative ranking of a set of compounds, a prioritization of groups of compounds (e.g., low, medium, and high) does emerge, which allows for the chemistry efforts to be quickly focused on the most viable candidates. Thus, this illustrates that it is not always necessary to have a high correlation between a computational score and the experimental data to impact the drug discovery process.

The Whole Library Handbook 3: Current Data, Professional Advice, and Curiosa about Libraries and Library Services.

ERIC Educational Resources Information Center

Eberhart, George M., Comp.

This handbook contains articles, guidelines, and other information from the field of library science organized into the following chapters: (1) "Libraries," including some basic figures, academic libraries, public libraries, school libraries, special libraries, national libraries, state libraries, small libraries, facilities, the past, and the…

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N

1977-01-01

This revised list of 472 books and 138 journals is intended as a selection guide for small or medium-sized hospital libraries or for the small medical library serving a specified clientele. It can also be used as a core list by small hospital library consortia. Books and journals are categorized by subject, with the books being followed by an author index and the journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries are indicated by an asterisk. To purchase the entire collection of books and to pay for annual subscriptions to all the journals would require an expenditure of about $18,200. The cost of only the asterisked items recommended for first purchase totals approximately $4,500. PMID:321057

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1979-01-01

This revised list of 492 books and 138 journals is intended as a selection guide for small or medium-sized hospital libraries or for the small medical library serving a specified clientele. It can also be used as a core list by small hospital library consortia. Books and journals are categorized by subject, with the books being followed by an author index and the journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries are indicated by an asterisk. To purchase the entire collection of books and to pay for annual subscriptions to all the journals would require an expenditure of about $22,500. The cost of only the asterisked items, recommended for first purchase, totals approximately $6,100. PMID:380695

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N; Hill, D R

1981-04-01

This revised list of 539 books and 136 journals is intended as a selection guide for small or medium-sized hospital libraries or for small medical libraries in comparable health care facilities. It can also be used as a core list by consortia of small hospital libraries. Books and journals are categorized by subject; the book list is followed by an author index and the list of journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries, 137 books and 54 journals, are indicated by asterisks. To purchase the entire collection of books and to pay for annual subscriptions to all the journals would require an expenditure of about $30,000. The cost of only the asterisked items, which are recommended for first purchase, totals approximately $8,900.

The heterogeneity statistic I(2) can be biased in small meta-analyses.

PubMed

von Hippel, Paul T

2015-04-14

Estimated effects vary across studies, partly because of random sampling error and partly because of heterogeneity. In meta-analysis, the fraction of variance that is due to heterogeneity is estimated by the statistic I(2). We calculate the bias of I(2), focusing on the situation where the number of studies in the meta-analysis is small. Small meta-analyses are common; in the Cochrane Library, the median number of studies per meta-analysis is 7 or fewer. We use Mathematica software to calculate the expectation and bias of I(2). I(2) has a substantial bias when the number of studies is small. The bias is positive when the true fraction of heterogeneity is small, but the bias is typically negative when the true fraction of heterogeneity is large. For example, with 7 studies and no true heterogeneity, I(2) will overestimate heterogeneity by an average of 12 percentage points, but with 7 studies and 80 percent true heterogeneity, I(2) can underestimate heterogeneity by an average of 28 percentage points. Biases of 12-28 percentage points are not trivial when one considers that, in the Cochrane Library, the median I(2) estimate is 21 percent. The point estimate I(2) should be interpreted cautiously when a meta-analysis has few studies. In small meta-analyses, confidence intervals should supplement or replace the biased point estimate I(2).

Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening

PubMed Central

Dandapani, Sivaraman; Rosse, Gerard; Southall, Noel; Salvino, Joseph M.; Thomas, Craig J.

2015-01-01

The selection, acquisition and use of high quality small molecule libraries for screening is an essential aspect of drug discovery and chemical biology programs. Screening libraries continue to evolve as researchers gain a greater appreciation of the suitability of small molecules for specific biological targets, processes and environments. The decisions surrounding the make-up of any given small molecule library is informed by a multitude of variables and opinions vary on best-practices. The fitness of any collection relies upon upfront filtering to avoiding problematic compounds, assess appropriate physicochemical properties, install the ideal level of structural uniqueness and determine the desired extent of molecular complexity. These criteria are under constant evaluation and revision as academic and industrial organizations seek out collections that yield ever improving results from their screening portfolios. Practical questions including cost, compound management, screening sophistication and assay objective also play a significant role in the choice of library composition. This overview attempts to offer advice to all organizations engaged in small molecule screening based upon current best practices and theoretical considerations in library selection and acquisition. PMID:26705509

Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.

PubMed

Dandapani, Sivaraman; Rosse, Gerard; Southall, Noel; Salvino, Joseph M; Thomas, Craig J

The selection, acquisition and use of high quality small molecule libraries for screening is an essential aspect of drug discovery and chemical biology programs. Screening libraries continue to evolve as researchers gain a greater appreciation of the suitability of small molecules for specific biological targets, processes and environments. The decisions surrounding the make-up of any given small molecule library is informed by a multitude of variables and opinions vary on best-practices. The fitness of any collection relies upon upfront filtering to avoiding problematic compounds, assess appropriate physicochemical properties, install the ideal level of structural uniqueness and determine the desired extent of molecular complexity. These criteria are under constant evaluation and revision as academic and industrial organizations seek out collections that yield ever improving results from their screening portfolios. Practical questions including cost, compound management, screening sophistication and assay objective also play a significant role in the choice of library composition. This overview attempts to offer advice to all organizations engaged in small molecule screening based upon current best practices and theoretical considerations in library selection and acquisition.

Discover Earth: An earth system science program for libraries and their communities

NASA Astrophysics Data System (ADS)

Curtis, L.; Dusenbery, P.

2010-12-01

The view from space has deepened our understanding of Earth as a global, dynamic system. Instruments on satellites and spacecraft, coupled with advances in ground-based research, have provided us with astonishing new perspectives of our planet. Now more than ever, enhancing the public’s understanding of Earth’s physical and biological systems is vital to helping citizens make informed policy decisions especially when they are faced with the consequences of global climate change. In spite of this relevance, there are many obstacles to achieving broad public understanding of key earth system science (ESS) concepts. Strategies for addressing climate change can only succeed with the full engagement of the general public. As reported by U.S. News and World Report in 2010, small towns in rural America are emerging as the front line in the climate change debate in the country. The Space Science Institute’s National Center for Interactive Learning (NCIL) in partnership with the American Library Association (ALA), the Lunar and Planetary Institute (LPI), and the National Girls Collaborative Project (NGCP) have received funding from NSF to develop a national project called the STAR Library Education Network: a hands-on learning program for libraries and their communities (or STAR-Net for short). STAR stands for Science-Technology, Activities and Resources. There are two distinct components of STAR-Net: Discover Earth and Discover Tech. While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. The overarching goal of the project is to reach underserved youth and their families with informal STEM learning experiences. The Discover Earth part of STAR_Net will produce ESS resources and inquiry-based activities that libraries can use to enrich the exhibit experience (focused on weather and climate). Additional resources will be provided through partnerships with relevant professional science organizations (e.g. American Geophysical Union) that will provide speakers for host library events and webinars. Online and in-person workshops will be conducted for library staff with a focus on increasing content knowledge and improving facilitation expertise. This presentation will provide an overview of the Discover Earth project and how it will address climate change issues, engage AGU scientists, and impact rural libraries nationwide.

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1981-01-01

This revised list of 539 books and 136 journals is intended as a selection guide for small or medium-sized hospital libraries or for small medical libraries in comparable health care facilities. It can also be used as a core list by consortia of small hospital libraries. Books and journals are categorized by subject; the book list is followed by an author index and the list of journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries, 137 books and 54 journals, are indicated by asterisks. To purchase the entire collection of books and to pay for annual subscriptions to all the journals would require an expenditure of about $30,000. The cost of only the asterisked items, which are recommended for first purchase, totals approximately $8,900. PMID:7225656

Assessment of Outcome-Focused Library Instruction in Psychology.

ERIC Educational Resources Information Center

Daugherty, Timothy K.; Carter, Elizabeth W.

1997-01-01

A sample of 49 non-psychology majors taking a course integrating library research skills with social science research showed increases in skill level, efficiency, and positive attitudes toward the library after a semester of outcome-focused instruction. The results suggest that co-development between course and library faculty can be an effective…

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

PubMed

Joshi, Priyanka; Chia, Sean; Habchi, Johnny; Knowles, Tuomas P J; Dobson, Christopher M; Vendruscolo, Michele

2016-03-14

The aggregation process of intrinsically disordered proteins (IDPs) has been associated with a wide range of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Currently, however, no drug in clinical use targets IDP aggregation. To facilitate drug discovery programs in this important and challenging area, we describe a fragment-based approach of generating small-molecule libraries that target specific IDPs. The method is based on the use of molecular fragments extracted from compounds reported in the literature to inhibit of the aggregation of IDPs. These fragments are used to screen existing large generic libraries of small molecules to form smaller libraries specific for given IDPs. We illustrate this approach by describing three distinct small-molecule libraries to target, Aβ, tau, and α-synuclein, which are three IDPs implicated in Alzheimer's and Parkinson's diseases. The strategy described here offers novel opportunities for the identification of effective molecular scaffolds for drug discovery for neurodegenerative disorders and to provide insights into the mechanism of small-molecule binding to IDPs.

Libraries on the MOVE.

ERIC Educational Resources Information Center

Edgar, Jim; And Others

1986-01-01

Presents papers from Illinois State Library and Shawnee Library System's "Libraries on the MOVE" conference focusing on how libraries can impact economic/cultural climate of an area. Topics addressed included information services of rural libraries; marketing; rural library development; library law; information access; interagency…

Analysis of Requirements of On-Line Network Cataloging Services for Small, Academic, Public, School and Other Libraries: A Demonstration Project using the OCLC System. Final Report.

ERIC Educational Resources Information Center

Markuson, Barbara Evans

This report results from a project using the OCLC system to provide catalog services to small libraries. Alternatives described include: centralized cataloging, centralized book processing, sharing of OCLC terminals, and use of dial-up terminals. The OCLC data base was found useful for all types of small libraries. It is recommended that network…

Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View.

PubMed

Yuen, Lik Hang; Franzini, Raphael M

2017-05-04

DNA-encoded chemical libraries (DECLs) are pools of DNA-tagged small molecules that enable facile screening and identification of bio-macromolecule binders. The successful development of DECLs has led to their increasingly important role in drug development, and screening hits have entered clinical trials. In this review, we summarize the development and currently active research areas of DECLs with a focus on contributions from groups at academic institutes. We further look at opportunities and future directions of DECL research in medicinal chemistry and chemical biology based on the symbiotic relationship between academia and industry. Challenges associated with the application of DECLs in academic drug discovery are further discussed. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Book swapping and book exchange libraries: Aspects of the phenomenon and the case of Greece

NASA Astrophysics Data System (ADS)

Bikos, Georgios; Papadimitriou, Panagiota

2015-02-01

We have over the past years been witnessing an ever growing book-swapping movement, having begun its course from the mere existence of bookshelves offering books to be traded in public places or via the internet and ending with small exchange and free to use libraries scattered in different areas. We believe that through this movement an answer is being uttered to the request for a better world and against the economic crisis, which is also a crisis of values. Based on this perspective, in this paper, we first attempt an overall presentation of the phenomenon and its characteristics, as they manifest themselves worldwide. Then, we focus on aspects of relevant attempts in Greece, taking their first tentative steps.

Envisioning the Academic Library: A Reflection on Roles, Relevancy and Relationships

ERIC Educational Resources Information Center

Delaney, Geraldine; Bates, Jessica

2015-01-01

The focus of this article is to reflect on current and near future issues and trends concerning academic libraries. This includes an overview of the literature on embedded librarianship and a focus on the need for more participatory and collaborative approaches to library services. The core argument is that academic libraries need to continue to…

Mixture-based combinatorial libraries from small individual peptide libraries: a case study on α1-antitrypsin deficiency.

PubMed

Chang, Yi-Pin; Chu, Yen-Ho

2014-05-16

The design, synthesis and screening of diversity-oriented peptide libraries using a "libraries from libraries" strategy for the development of inhibitors of α1-antitrypsin deficiency are described. The major buttress of the biochemical approach presented here is the use of well-established solid-phase split-and-mix method for the generation of mixture-based libraries. The combinatorial technique iterative deconvolution was employed for library screening. While molecular diversity is the general consideration of combinatorial libraries, exquisite design through systematic screening of small individual libraries is a prerequisite for effective library screening and can avoid potential problems in some cases. This review will also illustrate how large peptide libraries were designed, as well as how a conformation-sensitive assay was developed based on the mechanism of the conformational disease. Finally, the combinatorially selected peptide inhibitor capable of blocking abnormal protein aggregation will be characterized by biophysical, cellular and computational methods.

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.

PubMed

Huryn, Donna M; Brodsky, Jeffrey L; Brummond, Kay M; Chambers, Peter G; Eyer, Benjamin; Ireland, Alex W; Kawasumi, Masaoki; Laporte, Matthew G; Lloyd, Kayla; Manteau, Baptiste; Nghiem, Paul; Quade, Bettina; Seguin, Sandlin P; Wipf, Peter

2011-04-26

Unique chemical methodology enables the synthesis of innovative and diverse scaffolds and chemotypes and allows access to previously unexplored "chemical space." Compound collections based on such new synthetic methods can provide small-molecule probes of proteins and/or pathways whose functions are not fully understood. We describe the identification, characterization, and evolution of two such probes. In one example, a pathway-based screen for DNA damage checkpoint inhibitors identified a compound, MARPIN (ATM and ATR pathway inhibitor) that sensitizes p53-deficient cells to DNA-damaging agents. Modification of the small molecule and generation of an immobilized probe were used to selectively bind putative protein target(s) responsible for the observed activity. The second example describes a focused library approach that relied on tandem multicomponent reaction methodologies to afford a series of modulators of the heat shock protein 70 (Hsp70) molecular chaperone. The synthesis of libraries based on the structure of MAL3-101 generated a collection of chemotypes, each modulating Hsp70 function, but exhibiting divergent pharmacological activities. For example, probes that compromise the replication of a disease-associated polyomavirus were identified. These projects highlight the importance of chemical methodology development as a source of small-molecule probes and as a drug discovery starting point.

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

PubMed Central

Huryn, Donna M.; Brodsky, Jeffrey L.; Brummond, Kay M.; Chambers, Peter G.; Eyer, Benjamin; Ireland, Alex W.; Kawasumi, Masaoki; LaPorte, Matthew G.; Lloyd, Kayla; Manteau, Baptiste; Nghiem, Paul; Quade, Bettina; Seguin, Sandlin P.; Wipf, Peter

2011-01-01

Unique chemical methodology enables the synthesis of innovative and diverse scaffolds and chemotypes and allows access to previously unexplored “chemical space.” Compound collections based on such new synthetic methods can provide small-molecule probes of proteins and/or pathways whose functions are not fully understood. We describe the identification, characterization, and evolution of two such probes. In one example, a pathway-based screen for DNA damage checkpoint inhibitors identified a compound, MARPIN (ATM and ATR pathway inhibitor) that sensitizes p53-deficient cells to DNA-damaging agents. Modification of the small molecule and generation of an immobilized probe were used to selectively bind putative protein target(s) responsible for the observed activity. The second example describes a focused library approach that relied on tandem multicomponent reaction methodologies to afford a series of modulators of the heat shock protein 70 (Hsp70) molecular chaperone. The synthesis of libraries based on the structure of MAL3-101 generated a collection of chemotypes, each modulating Hsp70 function, but exhibiting divergent pharmacological activities. For example, probes that compromise the replication of a disease-associated polyomavirus were identified. These projects highlight the importance of chemical methodology development as a source of small-molecule probes and as a drug discovery starting point. PMID:21502524

A Manual for Small Libraries in Alaska.

ERIC Educational Resources Information Center

Kolb, Audrey

Intended as a guide and resource for staff and volunteers in small public libraries in Alaska, this manual is divided into the following chapters: (1) "Establishing a Library," which covers the establishment by ordinance or by organization of a non-profit corporation, information on drafting bylaws, and the role and responsibilities of…

Continuing Education for the Personnel of Small Public Libraries: Program Development at the Iowa State University Library and Its Public Services Course. Iowa State University Library Series in Continuing Education, no. 2.

ERIC Educational Resources Information Center

Shonrock, Diana D.

This report describes the planning, implementation, and evaluation of a coordinated staff development program to offer certified, non-degree credit to non-professional librarians from small public libraries. The program plan includes a course consisting of five 3-hour sessions covering the reference interview; interlibrary loan, government…

Planning & Urban Affairs Library Manual.

ERIC Educational Resources Information Center

Knobbe, Mary L., Ed.; Lessel, Janice W., Ed.

Written especially for persons without a library degree who are operating a small urban study or planning agency library on a part-time basis. Subjects covered are: (1) library function and staff function, duties and training; (2) physical layout and equipment of library; (3) establishing and maintaining the library; (4) library administration;…

An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.

PubMed

Seifert, Alexander; Antonovici, Mihaela; Hauer, Bernhard; Pleiss, Jürgen

2011-06-14

Perillyl alcohol is the terminal hydroxylation product of the cheap and readily available terpene, limonene. It has high potential as an anti-tumor substance, but is of limited availability. In principle, cytochrome P450 monooxygenases, such as the self-sufficient CYP102A1, are promising catalysts for the oxidation of limonene or other inert hydrocarbons. The wild-type enzyme converts (4R)-limonene to four different oxidation products; however, terminal hydroxylation at the allylic C7 is not observed. Here we describe a generic strategy to engineer this widely used enzyme to hydroxylate exclusively the exposed, but chemically less reactive, primary C7 in the presence of other reactive positions. The approach presented here turns CYP102A1 into a highly selective catalyst with a shifted product spectra by successive rounds of modeling, the design of small focused libraries, and screening. In the first round a minimal CYP102A1 mutant library was rationally designed. It contained variants with improved or strongly shifted regio-, stereo- and chemoselectivity, compared to wild-type. From this library the variant with the highest perillyl alcohol ratio was fine-tuned by two additional rounds of molecular modeling, diversification, and screening. In total only 29 variants needed to be screened to identify the triple mutant A264V/A238V/L437F that converts (4R)-limonene to perillyl alcohol with a selectivity of 97 %. Focusing mutagenesis on a small number of relevant positions identified by computational approaches is the key for efficient screening for enzyme selectivity. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Library on the Go: A Focus Group Study of the Mobile Web and the Academic Library

ERIC Educational Resources Information Center

Seeholzer, Jamie; Salem, Joseph A., Jr.

2011-01-01

This study explores student use of the mobile Web in general and expectations for an academic library's mobile Web site in particular through focus groups with students at Kent State University. Participants expressed more interest in using their mobile Web device to interact with library resources and services than anticipated. Results showed an…

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N; Hill, D R

1991-04-01

The current financial status of the health care industry is viewed both from its effect on the hospital library collection and the response of the hospital library to the financial crisis. Predecessors of this list have been intended as selection guides for a small or medium-size library in a hospital or comparable medical facility. As the prices of books and journals continue to soar, the secondary purpose as a core collection for a consortium of small hospital libraries or a network sharing library resources may eventually become its primary use. Books (607) and journals (140) are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals by an alphabetical title listing. To purchase the entire collection of books and to pay for 1991 subscriptions would require about $77,700. The cost of only the asterisked items totals $29,300.

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1991-01-01

The current financial status of the health care industry is viewed both from its effect on the hospital library collection and the response of the hospital library to the financial crisis. Predecessors of this list have been intended as selection guides for a small or medium-size library in a hospital or comparable medical facility. As the prices of books and journals continue to soar, the secondary purpose as a core collection for a consortium of small hospital libraries or a network sharing library resources may eventually become its primary use. Books (607) and journals (140) are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals by an alphabetical title listing. To purchase the entire collection of books and to pay for 1991 subscriptions would require about $77,700. The cost of only the asterisked items totals $29,300. PMID:2039906

Small Public Library Management

ERIC Educational Resources Information Center

Pearlmutter, Jane; Nelson, Paul

2012-01-01

Anyone at the helm of a small public library knows that every little detail counts. But juggling the responsibilities that are part and parcel of the job is far from easy. Finally, here's a handbook that includes everything administrators need to keep a handle on library operations, freeing them up to streamline and improve how the organization…

InfoQUEST: An Online Catalog for Small Libraries.

ERIC Educational Resources Information Center

Campbell, Bonnie

1984-01-01

InfoQUEST is a microcomputer-based online public access catalog, designed for the small library handling file sizes up to 25,000 records. Based on the IBM-PC, or compatible machines, the system will accept downloading, in batch mode, of records from the library's file on the UTLAS Catalog Support System. (Author/EJS)

Design, synthesis and selection of DNA-encoded small-molecule libraries.

PubMed

Clark, Matthew A; Acharya, Raksha A; Arico-Muendel, Christopher C; Belyanskaya, Svetlana L; Benjamin, Dennis R; Carlson, Neil R; Centrella, Paolo A; Chiu, Cynthia H; Creaser, Steffen P; Cuozzo, John W; Davie, Christopher P; Ding, Yun; Franklin, G Joseph; Franzen, Kurt D; Gefter, Malcolm L; Hale, Steven P; Hansen, Nils J V; Israel, David I; Jiang, Jinwei; Kavarana, Malcolm J; Kelley, Michael S; Kollmann, Christopher S; Li, Fan; Lind, Kenneth; Mataruse, Sibongile; Medeiros, Patricia F; Messer, Jeffrey A; Myers, Paul; O'Keefe, Heather; Oliff, Matthew C; Rise, Cecil E; Satz, Alexander L; Skinner, Steven R; Svendsen, Jennifer L; Tang, Lujia; van Vloten, Kurt; Wagner, Richard W; Yao, Gang; Zhao, Baoguang; Morgan, Barry A

2009-09-01

Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a long-sought goal. We report the synthesis and interrogation of an 800-million-member DNA-encoded library in which small molecules are covalently attached to an encoding oligonucleotide. The library was assembled by a combination of chemical and enzymatic synthesis, and interrogated by affinity selection. We describe methods for the selection and deconvolution of the chemical display library, and the discovery of inhibitors for two enzymes: Aurora A kinase and p38 MAP kinase.

A Place To Learn or a Place for Pleasure? Pupils' Uses of the School Library in Norway.

ERIC Educational Resources Information Center

Rafste, Elisabeth Tallaksen

This document summarizes a doctoral dissertation that examined activities in school libraries, including educational and leisure activities. The research focused on how pupils in two senior high schools in Norway use the school library in their everyday life at school, who the users are, and what use of the library means to them. The focus was…

Focus on Young Adult Programming.

ERIC Educational Resources Information Center

Union, Bunni; Williams, Sheila

1996-01-01

Presents three library youth service programs which focus on "Pizza and Politicians," a public library pizza party which gave high school students and college-aged young adults a chance to meet and question politicians; a young adult "Reading to Seniors" program; "Making Books," a public library journal-making project…

An efficient and sensitive method for preparing cDNA libraries from scarce biological samples

PubMed Central

Sterling, Catherine H.; Veksler-Lublinsky, Isana; Ambros, Victor

2015-01-01

The preparation and high-throughput sequencing of cDNA libraries from samples of small RNA is a powerful tool to quantify known small RNAs (such as microRNAs) and to discover novel RNA species. Interest in identifying the small RNA repertoire present in tissues and in biofluids has grown substantially with the findings that small RNAs can serve as indicators of biological conditions and disease states. Here we describe a novel and straightforward method to clone cDNA libraries from small quantities of input RNA. This method permits the generation of cDNA libraries from sub-picogram quantities of RNA robustly, efficiently and reproducibly. We demonstrate that the method provides a significant improvement in sensitivity compared to previous cloning methods while maintaining reproducible identification of diverse small RNA species. This method should have widespread applications in a variety of contexts, including biomarker discovery from scarce samples of human tissue or body fluids. PMID:25056322

Making It to the Major Leagues: Career Movement between Library and Archival Professions and from Small College to Large University Libraries.

ERIC Educational Resources Information Center

Johnson, Timothy J.

2002-01-01

Examines issues of career movement and change between library and archival fields and from small colleges to large universities. Topics include professional education and training; initial career planning and placement; continuing education; scouting and mentoring; job market conditions; work experience and personal skills; professional…

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

PubMed

Wu, Zining; Graybill, Todd L; Zeng, Xin; Platchek, Michael; Zhang, Jean; Bodmer, Vera Q; Wisnoski, David D; Deng, Jianghe; Coppo, Frank T; Yao, Gang; Tamburino, Alex; Scavello, Genaro; Franklin, G Joseph; Mataruse, Sibongile; Bedard, Katie L; Ding, Yun; Chai, Jing; Summerfield, Jennifer; Centrella, Paolo A; Messer, Jeffrey A; Pope, Andrew J; Israel, David I

2015-12-14

DNA-encoded small-molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, this technology has been used with soluble protein targets that are produced and used in a purified state. Here, we describe a cell-based method for identifying small-molecule ligands from DNA-encoded libraries against integral membrane protein targets. We use this method to identify novel, potent, and specific inhibitors of NK3, a member of the tachykinin family of G-protein coupled receptors (GPCRs). The method is simple and broadly applicable to other GPCRs and integral membrane proteins. We have extended the application of DNA-encoded library technology to membrane-associated targets and demonstrate the feasibility of selecting DNA-tagged, small-molecule ligands from complex combinatorial libraries against targets in a heterogeneous milieu, such as the surface of a cell.

Marketing in the Special Library Environment.

ERIC Educational Resources Information Center

Powers, Janet E.

1995-01-01

Special libraries developed in response to a need for quick access to specific information. Integrated marketing in special libraries focuses the library toward strategic planning and offers the opportunity to develop more effective library services. (Author/AEF)

"Doing the Best You Can with What You Have:" Lessons Learned from Outcomes Assessment.

ERIC Educational Resources Information Center

Carter, Elizabeth W.

2002-01-01

Discusses outcomes focused assessments of library research instruction using pretests and posttests, attitude and usage surveys, and focus groups at The Citadel library. Suggests that assessment results influence library instruction content, staffing, collection development, and collaboration with other faculty and academic departments.…

Investing for a Future: Client-Focused Australian Academic Libraries in the 1990s.

ERIC Educational Resources Information Center

Bundy, Alan

1997-01-01

Because government funding to Australia's universities is being cut, university libraries must publicize newly developed approaches to strategic planning and client-focused performance to ensure institutional investment. This article examines university library clients and the extent to which Australian universities have clients in mind when…

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

NASA Astrophysics Data System (ADS)

Litovchick, Alexander; Dumelin, Christoph E.; Habeshian, Sevan; Gikunju, Diana; Guié, Marie-Aude; Centrella, Paolo; Zhang, Ying; Sigel, Eric A.; Cuozzo, John W.; Keefe, Anthony D.; Clark, Matthew A.

2015-06-01

A chemical ligation method for construction of DNA-encoded small-molecule libraries has been developed. Taking advantage of the ability of the Klenow fragment of DNA polymerase to accept templates with triazole linkages in place of phosphodiesters, we have designed a strategy for chemically ligating oligonucleotide tags using cycloaddition chemistry. We have utilized this strategy in the construction and selection of a small molecule library, and successfully identified inhibitors of the enzyme soluble epoxide hydrolase.

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N

1975-01-01

This revised list of 446 books and 137 journals is intended as a selection guide for small or medium-sized hospital libraries or for the small medical library serving a specified clientele. Books and journals are categorized by subject, with the books being followed by an author index and the journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries are indicated by an asterisk. To purchase the entire collection of books and to pay for annual subscriptions to all the journals would require an expenditure for about $14,500. The cost of only the asterisked items recommended for first purchase totals approximately $4,100. PMID:1095095

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N

1975-04-01

This revised list of 446 books and 137 journals is intended as a selection guide for small or medium-sized hospital libraries or for the small medical library serving a specified clientele. Books and journals are categorized by subject, with the books being followed by an author index and the journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries are indicated by an asterisk. To purchase the entire collection of books and to pay for annual subscriptions to all the journals would require an expenditure for about $14,500. The cost of only the asterisked items recommended for first purchase totals approximately $4,100.

Library Computing.

ERIC Educational Resources Information Center

Goodgion, Laurel; And Others

1986-01-01

Eight articles in special supplement to "Library Journal" and "School Library Journal" cover a computer program called "Byte into Books"; microcomputers and the small library; creating databases with students; online searching with a microcomputer; quality automation software; Meckler Publishing Company's…

Library Buildings Section. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on library architecture, which were presented at the 1982 International Federation of Library Associations (IFLA) conference focus on the effect of library networks on library design. Topics include: (1) "Some Problems in Designing of the University Library Buildings in China: A Developing Country University Librarian's View Based on…

Toward Continual Reform: Progress in Academic Libraries in China.

ERIC Educational Resources Information Center

Ping, Ke

2002-01-01

Traces developments in China's academic libraries: managing human resources, restructuring library developments, revising and implementing new policies, evaluating services and operations, establishing library systems, building new structures, and exploring joint-use library models. Major focus was to improve services for library user. (Author/LRW)

User Perceptions of the Library's Web Pages: A Focus Group Study at Texas A&M University.

ERIC Educational Resources Information Center

Crowley, Gwyneth H.; Leffel, Rob; Ramirez, Diana; Hart, Judith L.; Armstrong, Tommy S., II

2002-01-01

This focus group study explored library patrons' opinions about Texas A&M library's Web pages. Discusses information seeking behavior which indicated that patrons are confused when trying to navigate the Public Access Menu and suggests the need for a more intuitive interface. (Author/LRW)

User Perceptions of the "Reliability" of Library Services at Texas A&M University: A Focus Group Study.

ERIC Educational Resources Information Center

Ho, Jeannette; Crowley, Gwyneth H.

2003-01-01

Explored user perceptions of dependability and accuracy of Texas A&M library services through focus groups. Reports user difficulties in locating materials, inaccurate catalog and circulation records, inadequate signage, searching the online catalog, and late notification of interlibrary loan arrivals; and discusses the library's efforts to…

Library Space Redesign and Student Computing

ERIC Educational Resources Information Center

Teleha, John C.; Sims, Iyanna; Spruill, Octavious; Bowen, Arneice; Russell, Tiffany; Exner, Nina

2017-01-01

Academic libraries are spending considerable time and study on redesigning spaces. The use of technology is often an important part of these redesigned spaces. The space redesign goals at F. D. Bluford Library focus on creating open, activity-promoting, colorful spaces that are designed to be attractive to students. The goals also focus on…

High content screening of defined chemical libraries using normal and glioma-derived neural stem cell lines.

PubMed

Danovi, Davide; Folarin, Amos A; Baranowski, Bart; Pollard, Steven M

2012-01-01

Small molecules with potent biological effects on the fate of normal and cancer-derived stem cells represent both useful research tools and new drug leads for regenerative medicine and oncology. Long-term expansion of mouse and human neural stem cells is possible using adherent monolayer culture. These cultures represent a useful cellular resource to carry out image-based high content screening of small chemical libraries. Improvements in automated microscopy, desktop computational power, and freely available image processing tools, now means that such chemical screens are realistic to undertake in individual academic laboratories. Here we outline a cost effective and versatile time lapse imaging strategy suitable for chemical screening. Protocols are described for the handling and screening of human fetal Neural Stem (NS) cell lines and their malignant counterparts, Glioblastoma-derived neural stem cells (GNS). We focus on identification of cytostatic and cytotoxic "hits" and discuss future possibilities and challenges for extending this approach to assay lineage commitment and differentiation. Copyright © 2012 Elsevier Inc. All rights reserved.

Towards a high performance geometry library for particle-detector simulations

DOE PAGES

Apostolakis, J.; Bandieramonte, M.; Bitzes, G.; ...

2015-05-22

Thread-parallelization and single-instruction multiple data (SIMD) ”vectorisation” of software components in HEP computing has become a necessity to fully benefit from current and future computing hardware. In this context, the Geant-Vector/GPU simulation project aims to re-engineer current software for the simulation of the passage of particles through detectors in order to increase the overall event throughput. As one of the core modules in this area, the geometry library plays a central role and vectorising its algorithms will be one of the cornerstones towards achieving good CPU performance. Here, we report on the progress made in vectorising the shape primitives, asmore » well as in applying new C++ template based optimizations of existing code available in the Geant4, ROOT or USolids geometry libraries. We will focus on a presentation of our software development approach that aims to provide optimized code for all use cases of the library (e.g., single particle and many-particle APIs) and to support different architectures (CPU and GPU) while keeping the code base small, manageable and maintainable. We report on a generic and templated C++ geometry library as a continuation of the AIDA USolids project. As a result, the experience gained with these developments will be beneficial to other parts of the simulation software, such as for the optimization of the physics library, and possibly to other parts of the experiment software stack, such as reconstruction and analysis.« less

Towards a high performance geometry library for particle-detector simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Apostolakis, J.; Bandieramonte, M.; Bitzes, G.

Thread-parallelization and single-instruction multiple data (SIMD) ”vectorisation” of software components in HEP computing has become a necessity to fully benefit from current and future computing hardware. In this context, the Geant-Vector/GPU simulation project aims to re-engineer current software for the simulation of the passage of particles through detectors in order to increase the overall event throughput. As one of the core modules in this area, the geometry library plays a central role and vectorising its algorithms will be one of the cornerstones towards achieving good CPU performance. Here, we report on the progress made in vectorising the shape primitives, asmore » well as in applying new C++ template based optimizations of existing code available in the Geant4, ROOT or USolids geometry libraries. We will focus on a presentation of our software development approach that aims to provide optimized code for all use cases of the library (e.g., single particle and many-particle APIs) and to support different architectures (CPU and GPU) while keeping the code base small, manageable and maintainable. We report on a generic and templated C++ geometry library as a continuation of the AIDA USolids project. As a result, the experience gained with these developments will be beneficial to other parts of the simulation software, such as for the optimization of the physics library, and possibly to other parts of the experiment software stack, such as reconstruction and analysis.« less

"Glory Catalogued": The Libraries of Florence.

ERIC Educational Resources Information Center

Robbins, Wendy

1983-01-01

Narration of author's visit to the libraries of Florence, Italy, focuses on city, provincial, and national libraries, including the Laurentian Library, Biblioteca Communale Centrale (city), Biblioteca Marucelliana (regional), and Biblioteca Nazionale Centrale (national). Conversations with the directors of each library are highlighted. (EJS)

The Homeless in the Public Library: Implications for Access to Libraries.

ERIC Educational Resources Information Center

Simmons, Randall C.

1985-01-01

Discussion of the homeless in American public libraries focuses on harmless individuals who may be considered nuisance by library staff/patrons. Highlights include literature about problem library patrons, national problem, social issues, major themes (offense to others and library staff, balancing rights, and elitism), and implications for…

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1985-01-01

The interrelationship of print and electronic media in the hospital library and the relevance of the "Selected List" in 1985 are discussed in the introduction to this revised list of 583 books and 138 journals. The list is meant to be a selection guide for the small or medium-size library in a hospital or comparable medical facility, or a core collection for a consortium of small hospital libraries. Books and journals are categorized by subject; the book list is followed by an author/editor index and the subject list of journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries are indicated by asterisks. To purchase the entire collection of books and to pay for 1985 subscriptions to all the journals would require about $45,200. The cost of only the asterisked items totals approximately $16,100. PMID:3888331

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1987-01-01

The impact that the hospital librarian's use of management techniques and comprehension of the highly competitive health care environment can have on collection development and resulting information services in his or her library is reviewed in the introduction to this revised list of 600 books and 139 journals. The list is intended as a selection guide for the small or medium-size library in a hospital or comparable medical facility, or a core collection for a consortium of small hospital libraries. Books and journals are categorized by subject; the book list is followed by an author/editor index and the subject list of journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries are indicated by asterisks. To purchase the entire collection of books and to pay for 1987 subscriptions to all journals would require about $52,600. The cost of only the asterisked items totals approximately $21,000. PMID:3594025

One small community hospital library's successful outsourcing of document delivery: an ongoing study.

PubMed

Haas, V

2000-01-01

When DOCLINE was implemented in 1985, community hospital librarians were beginning to feel the economic pressures of the changing health care arena. However, staff and resources were often sufficient or plentiful. Now, fifteen years after the creation of DOCLINE, many existing small hospitals either no longer have a librarian, an assistant is managing the library, the librarian is managing one or more libraries of an integrated system, or the number of librarians has been reduced. A system that is heavily staff dependent is no longer feasible. In addition, as the role of the community hospital librarian evolves into one of instructor and patient education liaison, a system that does not permit the librarian to expand such services will be detrimental to the entire library program. Following is a discussion of one small community hospital's decision to outsource document delivery services as a result of staffing changes and the expansion of additional library programs.

National Knowledge Commission

NASA Astrophysics Data System (ADS)

Pitroda, Sam

2007-04-01

India's National Knowledge Commission (NKC) established by the prime minister is focused on building institutions and infrastructure in Education, Science and Technology, Innovation etc. to meet the challenges of the knowledge economy in the 21st century and increase India's competitive advantage in the global market. India today stands poised to reap the benefits of a rapidly growing economy and a major demographic advantage, with 550 million young people below the age of 25 years, the largest in the world. The NKC is focused on five critical areas of knowledge related to access, concepts, creation, applications and services. This includes a variety of subject areas such as language, translations, libraries, networks, portals, affirmative action, distance learning, intellectual property, Entrepreneurship, application in Agriculture, health, small and medium scale industries, e-governance etc. One of the keys to this effort is to build a national broadband gigabit of networks of 500 nodes to connect universities, Libraries, Laboratories, Hospitals, Agriculture institutions etc. to share resources and collaborate on multidisciplinary activities. This presentation will introduce the NKC, discuss methodology, subject areas, specific recommendation and outline a plan to build knowledge networks and specifics on network architecture, applications, and utilities.

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N

1971-04-01

This updated list of 389 books and 135 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. Items suggested for first purchase by smaller libraries are noted by an asterisk.

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N

1969-04-01

This updated list of 398 books and 141 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. Items suggested for first purchase by smaller libraries are noted by an asterisk.

The focus group technique in library research: an introduction.

PubMed Central

Glitz, B

1997-01-01

The focus group technique is one example of a qualitative research methodology used to explore the opinions, knowledge, perceptions, and concerns of individuals in regard to a particular topic. The focus group typically involves six to ten individuals who have some knowledge of or experience with the topic. The group discussion is led by a moderator who guides participants through a series of open-ended questions. The information gathered can provide important clues to human attitudes and values as they relate to the topic. Such information can be extremely useful to libraries that are trying to gain a better understanding of their patrons' needs and thus make better management decisions to help satisfy those needs. The technique can also be used successfully in conjunction with other research tools, such as surveys, either to help develop a questionnaire or to explain specific survey results. This paper introduces the use of focus groups in library research, the skills needed to conduct groups, and their strengths and weaknesses. Examples of the use of focus groups in health sciences libraries are presented, including the results of a survey from these libraries. PMID:9431428

The focus group technique in library research: an introduction.

PubMed

Glitz, B

1997-10-01

The focus group technique is one example of a qualitative research methodology used to explore the opinions, knowledge, perceptions, and concerns of individuals in regard to a particular topic. The focus group typically involves six to ten individuals who have some knowledge of or experience with the topic. The group discussion is led by a moderator who guides participants through a series of open-ended questions. The information gathered can provide important clues to human attitudes and values as they relate to the topic. Such information can be extremely useful to libraries that are trying to gain a better understanding of their patrons' needs and thus make better management decisions to help satisfy those needs. The technique can also be used successfully in conjunction with other research tools, such as surveys, either to help develop a questionnaire or to explain specific survey results. This paper introduces the use of focus groups in library research, the skills needed to conduct groups, and their strengths and weaknesses. Examples of the use of focus groups in health sciences libraries are presented, including the results of a survey from these libraries.

Small RNA Library Preparation Method for Next-Generation Sequencing Using Chemical Modifications to Prevent Adapter Dimer Formation.

PubMed

Shore, Sabrina; Henderson, Jordana M; Lebedev, Alexandre; Salcedo, Michelle P; Zon, Gerald; McCaffrey, Anton P; Paul, Natasha; Hogrefe, Richard I

2016-01-01

For most sample types, the automation of RNA and DNA sample preparation workflows enables high throughput next-generation sequencing (NGS) library preparation. Greater adoption of small RNA (sRNA) sequencing has been hindered by high sample input requirements and inherent ligation side products formed during library preparation. These side products, known as adapter dimer, are very similar in size to the tagged library. Most sRNA library preparation strategies thus employ a gel purification step to isolate tagged library from adapter dimer contaminants. At very low sample inputs, adapter dimer side products dominate the reaction and limit the sensitivity of this technique. Here we address the need for improved specificity of sRNA library preparation workflows with a novel library preparation approach that uses modified adapters to suppress adapter dimer formation. This workflow allows for lower sample inputs and elimination of the gel purification step, which in turn allows for an automatable sRNA library preparation protocol.

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

PubMed Central

Litovchick, Alexander; Dumelin, Christoph E.; Habeshian, Sevan; Gikunju, Diana; Guié, Marie-Aude; Centrella, Paolo; Zhang, Ying; Sigel, Eric A.; Cuozzo, John W.; Keefe, Anthony D.; Clark, Matthew A.

2015-01-01

A chemical ligation method for construction of DNA-encoded small-molecule libraries has been developed. Taking advantage of the ability of the Klenow fragment of DNA polymerase to accept templates with triazole linkages in place of phosphodiesters, we have designed a strategy for chemically ligating oligonucleotide tags using cycloaddition chemistry. We have utilized this strategy in the construction and selection of a small molecule library, and successfully identified inhibitors of the enzyme soluble epoxide hydrolase. PMID:26061191

Deciding the Future of the Catalog in Small Libraries.

ERIC Educational Resources Information Center

Anderson, David C.

1980-01-01

Discusses planning "future of the catalog" decisions given AACR2 and suggests that courses of action for small libraries may be developed through self-study and by reference to a list of 11 resources. (RAA)

IFLA General Conference 1988. Division of General Research Libraries. Section on National Libraries; Section on Parliamentary Libraries; Section on University Libraries and Other General Research Libraries; Section on Library History.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

The 12 papers in this compilation focus on the activities of general research libraries, i.e., national, parliamentary, and university libraries: (1) "Commercial and Revenue Raising Activities in National Libraries" (Maurice Line & Peter Scott, New Zealand); (2) "The End of All and Forever--On the Acquisition Policies of…

Facility Focus: Libraries.

ERIC Educational Resources Information Center

College Planning & Management, 2002

2002-01-01

Describes the design of the Charles V. Park Library at Central Michigan University and the Martha Rivers and E. Bronson Ingram Library, an addition to the Frederick Ferris Thompson Memorial Library at Vassar College. Discusses the libraries as examples of merging tradition with technology. Includes photographs. (EV)

Focus Groups and Usability Testing in Redesigning an Academic Library's Web Site

ERIC Educational Resources Information Center

Oldham, Bonnie W.

2008-01-01

As the World Wide Web has advanced since its inception, librarians have endeavored to keep pace with this progress in the design of their library Web pages. User recommendations collected from focus groups and usability testing have indicated that the University of Scranton's Weinberg Memorial Library's Web site was not working as intended, and…

Effectiveness of a liaison program in meeting information needs of college of pharmacy faculty.

PubMed

Kramer, Sandra S; Martin, Jennifer R; Schlimgen, Joan B; Slack, Marion K; Martin, Jim

2011-01-01

This article describes the creation and implementation of focus groups to evaluate the effectiveness of a health sciences library's liaison program of the College of Pharmacy faculty and to better understand the faculty's information needs in order to design new and improved library services. The liaison services support the teaching and research needs of faculty and students through literature research, classroom teaching, and an extensive library collection of pharmacy literature. Focus group results demonstrated a high level of satisfaction with library liaison services and collections. Opportunities exist for expanded interaction with graduate students and greater marketing of library services to increase faculty awareness of specific library programs.

Differently Able: A Review of Academic Library Websites for People with Disabilities

ERIC Educational Resources Information Center

Cassner, Mary; Maxey-Harris, Charlene; Anaya, Toni

2011-01-01

This research is based on the Library Services for People with Disabilities Policy, which was approved by the American Library Association in 2001. The policy identified focus areas for libraries including library services, facilities, collections, and assistive technology. Library websites frequently convey this information to users. Our study…

University Libraries and Other General Research Libraries Section. General Research Libraries Division. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on university and other research libraries, presented at the 1983 International Federation of Library Associations (IFLA) conference, include: (1) "The Impact of Technology on Users of Academic and Research Libraries," in which C. Lee Jones (United States) focuses on the impact of technical advances in computing and…

School Library Media Centers in a Statewide Network.

ERIC Educational Resources Information Center

Fox, Carol

1990-01-01

Description of library services in Illinois focuses on school libraries and youth services. Topics discussed include multitype library systems; automation; youth services consultants; data collection for youth services; resource sharing for schools; promotion of reading and library programs; communications networks; and standards and certification…

Hierarchical virtual screening approaches in small molecule drug discovery.

PubMed

Kumar, Ashutosh; Zhang, Kam Y J

2015-01-01

Virtual screening has played a significant role in the discovery of small molecule inhibitors of therapeutic targets in last two decades. Various ligand and structure-based virtual screening approaches are employed to identify small molecule ligands for proteins of interest. These approaches are often combined in either hierarchical or parallel manner to take advantage of the strength and avoid the limitations associated with individual methods. Hierarchical combination of ligand and structure-based virtual screening approaches has received noteworthy success in numerous drug discovery campaigns. In hierarchical virtual screening, several filters using ligand and structure-based approaches are sequentially applied to reduce a large screening library to a number small enough for experimental testing. In this review, we focus on different hierarchical virtual screening strategies and their application in the discovery of small molecule modulators of important drug targets. Several virtual screening studies are discussed to demonstrate the successful application of hierarchical virtual screening in small molecule drug discovery. Copyright © 2014 Elsevier Inc. All rights reserved.

Automating Small Libraries.

ERIC Educational Resources Information Center

Swan, James

1996-01-01

Presents a four-phase plan for small libraries strategizing for automation: inventory and weeding, data conversion, implementation, and enhancements. Other topics include selecting a system, MARC records, compatibility, ease of use, industry standards, searching capabilities, support services, system security, screen displays, circulation modules,…

Directory of Michigan Library Statistics. 1994 Edition. Reporting 1992 and 1993 Statistical Activities including: Public Library Statistics, Library Cooperative Statistics, Regional/Subregional Statistics.

ERIC Educational Resources Information Center

Leaf, Donald C., Comp.; Neely, Linda, Comp.

This edition focuses on statistical data supplied by Michigan public libraries, public library cooperatives, and those public libraries which serve as regional or subregional outlets for blind and physically handicapped services. Since statistics in Michigan academic libraries are typically collected in odd-numbered years, they are not included…

Selected List of Books and Journals for the Small Medical Library *

PubMed Central

Brandon, Alfred N.

1969-01-01

This updated list of 398 books and 141 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. Items suggested for first purchase by smaller libraries are noted by an asterisk. PMID:4888285

Selected List of Books and Journals for the Small Medical Library *

PubMed Central

Brandon, Alfred N.

1971-01-01

This updated list of 389 books and 135 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. Items suggested for first purchase by smaller libraries are noted by an asterisk. PMID:5582092

Applying Theory Y to Library Management

ERIC Educational Resources Information Center

Morton, Donald J.

1975-01-01

Reviews the principles of the Theory Y approach, reports upon its coverage in library literature, distinguishes between the concepts of Theory Y and participative management, and discusses how Theory Y's application in a small academic library recommends its use for library operations in general. (Author)

Some Libraries Do Everything Well! An Example of School/Public Library Cooperation.

ERIC Educational Resources Information Center

Kitchens, James A.; Bodart, Joni

1980-01-01

Describes the combined school and public library in Olney, Texas. The result of a community planning program, the combined facility offers a small town's solution for providing adequate library services for education and general use with limited resources. (RAA)

Microcomputers in the Anesthesia Library.

ERIC Educational Resources Information Center

Wright, A. J.

The combination of computer technology and library operation is helping to alleviate such library problems as escalating costs, increasing collection size, deteriorating materials, unwieldy arrangement schemes, poor subject control, and the acquisition and processing of large numbers of rarely used documents. Small special libraries such as…

Construction of the BAC Library of Small Abalone (Haliotis diversicolor) for Gene Screening and Genome Characterization.

PubMed

Jiang, Likun; You, Weiwei; Zhang, Xiaojun; Xu, Jian; Jiang, Yanliang; Wang, Kai; Zhao, Zixia; Chen, Baohua; Zhao, Yunfeng; Mahboob, Shahid; Al-Ghanim, Khalid A; Ke, Caihuan; Xu, Peng

2016-02-01

The small abalone (Haliotis diversicolor) is one of the most important aquaculture species in East Asia. To facilitate gene cloning and characterization, genome analysis, and genetic breeding of it, we constructed a large-insert bacterial artificial chromosome (BAC) library, which is an important genetic tool for advanced genetics and genomics research. The small abalone BAC library includes 92,610 clones with an average insert size of 120 Kb, equivalent to approximately 7.6× of the small abalone genome. We set up three-dimensional pools and super pools of 18,432 BAC clones for target gene screening using PCR method. To assess the approach, we screened 12 target genes in these 18,432 BAC clones and identified 16 positive BAC clones. Eight positive BAC clones were then sequenced and assembled with the next generation sequencing platform. The assembled contigs representing these 8 BAC clones spanned 928 Kb of the small abalone genome, providing the first batch of genome sequences for genome evaluation and characterization. The average GC content of small abalone genome was estimated as 40.33%. A total of 21 protein-coding genes, including 7 target genes, were annotated into the 8 BACs, which proved the feasibility of PCR screening approach with three-dimensional pools in small abalone BAC library. One hundred fifty microsatellite loci were also identified from the sequences for marker development in the future. The BAC library and clone pools provided valuable resources and tools for genetic breeding and conservation of H. diversicolor.

Keep Your Small Network Sailing Safely in Dangerous Waters

ERIC Educational Resources Information Center

Semmelroth, Jim

2006-01-01

Asmall library's essential technical problem is that it has to chart a course through the technology shoals without a navigator on board. Small libraries in small towns often have a very low level of technical skill on staff. Furthermore, obtaining skilled technical support can frequently be pretty expensive. Even when one is available, a clever…

Michigan Library Statistical Report. 1997 Edition.

ERIC Educational Resources Information Center

Michigan Library, Lansing.

This 1997 edition focuses on statistical data supplied by Michigan public libraries, public library cooperatives, and those public libraries which serve as regional or subregional outlets for blind and physically handicapped patrons. Statistics on academic libraries are also presented in this edition, and summary statistics for prior fiscal years…

Library Education in the ASEAN Countries.

ERIC Educational Resources Information Center

Atan, H. B.; Havard-Williams, P.

1987-01-01

Identifies the hierarchy of library development in Southeast Asian countries that results in the neglect of public and school libraries. Developing local library school curricula which focus on the specific needs of each country and cooperation among library schools are suggested as methods of correcting this situation. (CLB)

Special Problems in the Library Setting.

ERIC Educational Resources Information Center

Keller, Daniel P.

1997-01-01

Discussion of violence in the workplace focuses on libraries. Highlights include types of violence in libraries; recognizing warning signs of employee violence; preventive action; and strategies for a safer library, including appropriate security systems and other devices. (LRW)

Genetic diversity of small eukaryotes in lakes differing by their trophic status.

PubMed

Lefranc, Marie; Thénot, Aurélie; Lepère, Cécile; Debroas, Didier

2005-10-01

Small eukaryotes, cells with a diameter of less than 5 mum, are fundamental components of lacustrine planktonic systems. In this study, small-eukaryote diversity was determined by sequencing cloned 18S rRNA genes in three libraries from lakes of differing trophic status in the Massif Central, France: the oligotrophic Lake Godivelle, the oligomesotrophic Lake Pavin, and the eutrophic Lake Aydat. This analysis shows that the least diversified library was in the eutrophic lake (12 operational taxonomic units [OTUs]) and the most diversified was in the oligomesotrophic lake (26 OTUs). Certain groups were present in at least two ecosystems, while the others were specific to one lake on the sampling date. Cryptophyta, Chrysophyceae, and the strictly heterotrophic eukaryotes, Ciliophora and fungi, were identified in the three libraries. Among the small eukaryotes found only in two lakes, Choanoflagellida and environmental sequences (LKM11) were not detected in the eutrophic system whereas Cercozoa were confined to the oligomesotrophic and eutrophic lakes. Three OTUs, linked to the Perkinsozoa, were detected only in the Aydat library, where they represented 60% of the clones of the library. Chlorophyta and Haptophyta lineages were represented by a single clone and were present only in Godivelle and Pavin, respectively. Of the 127 clones studied, classical pigmented organisms (autotrophs and mixotrophs) represented only a low proportion regardless of the library's origin. This study shows that the small-eukaryote community composition may differ as a function of trophic status; certain lineages could be detected only in a single ecosystem.

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1989-01-01

In the introduction to this revised list of 607 books and 141 journals, quality assurance programs of health care institutions and patient education are suggested as vehicles for more directly involving the hospital library and its collection in patient care. This list is intended as a selection guide for the small or medium-sized library in a hospital or comparable medical facility, or as a core collection for a consortium of small hospital libraries. Books and journals are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals by an alphabetical title listing. To purchase the entire collection of books and to pay for 1989 subscriptions would require about $63,500. The cost of only the asterisked items totals $24,000. PMID:2655782

Users' Satisfaction with Library Services: A Case Study of Delta State University Library

ERIC Educational Resources Information Center

Ikolo, Violet E.

2015-01-01

The study focused on users' satisfaction with library services at the Delta State University main Library, Abraka, Delta State. The objective was to find out if users are satisfied with the services, facilities, the library environment, information sources and staff of the library. Using the descriptive survey design, the population for the study…

Vocational Students' and Instructors' Perceptions and Usage of COS Library Services.

ERIC Educational Resources Information Center

Parrott, Marietta; And Others

A study was conducted at College of the Sequoias (COS) to gather information about patterns of library utilization among vocational students. Specifically, the study focused on vocational students' attitudes toward libraries, differences between the attitudes of library users and non-users, factors influencing library use, vocational faculty use…

School Libraries in Hawaii.

ERIC Educational Resources Information Center

Bard, Therese Bissen

This paper outlines the history, functions, administration, and current focus of school library services in Hawaii, which is the only state in the United States with a library staffed by a trained librarian in every public school. Its first school library was established in 1882. Elementary school libraries developed concurrently with secondary…

Nicaragua's Libraries: A Struggle for Survival.

ERIC Educational Resources Information Center

Chepesiuk, Ron

1989-01-01

Description of the effects of the revolution, U.S. government policy, and natural disasters on the economic climate in Nicaragua focuses on problems faced by the country's libraries and library school. Support and funding provided to Nicaraguan libraries by American library groups are reviewed, and attitudes of Nicaraguan librarians toward the…

Start Making Sense: Practical Approaches to Outcomes Assessment for Libraries.

ERIC Educational Resources Information Center

Rabine, Julie; Cardwell, Catherine

2000-01-01

Discussion of the accountability of university libraries and assessment methods to show library effectiveness focuses on two assessment tools developed at Bowling Green State University: one program-level assessment which involved a student library skills assessment survey; and one class-level assessment which involved one-shot library instruction…

Planning for a New Generation of Public Library Buildings. The Greenwood Library Management Collection.

ERIC Educational Resources Information Center

McCabe, Gerard B.

This book on public library design and construction contains the following chapters: (1) "Beginning the Plan"; (2) "Data for Planning"; (3) "Location: Finding a Site"; (4) "Interior Design"; (5) "Furnishing and Equipping the Library and Its Environs"; (6) "Other Views," including "Using Small College Library Planning Techniques in Public Library…

The Value of Academic Libraries: Library Services as a Predictor of Student Retention

ERIC Educational Resources Information Center

Murray, Adam; Ireland, Ashley; Hackathorn, Jana

2016-01-01

This study examined the predictive relationship between library use by individual students and their retention status in university settings. The methodology builds on a small number of previous studies to examine library use at the individual level to determine if use of specific library services is predictive of retention for freshmen and…

Appropriate Use Policies for Computers in College/University Libraries. CLIP Note.

ERIC Educational Resources Information Center

Tuten, Jane, Comp.; Junker, Karen, Comp.

The purpose of this College Library Information Packet (CLIP) Note is to help libraries identify desirable elements found in computer use policies and to provide guidelines for college and small university libraries that want to develop policies or have been directed to implement policies for computer usage in their libraries. In January 2001, a…

Technostress and Library Values.

ERIC Educational Resources Information Center

Gorman, Michael

2001-01-01

Discusses information overload and society's and libraries' responses to technology. Considers eight values that libraries should focus on and how they relate to technology in libraries: democracy, stewardship, service, intellectual freedom, privacy, rationalism, equity of access, and building harmony and balance. (LRW)

Natural products used as a chemical library for protein-protein interaction targeted drug discovery.

PubMed

Jin, Xuemei; Lee, Kyungro; Kim, Nam Hee; Kim, Hyun Sil; Yook, Jong In; Choi, Jiwon; No, Kyoung Tai

2018-01-01

Protein-protein interactions (PPIs), which are essential for cellular processes, have been recognized as attractive therapeutic targets. Therefore, the construction of a PPI-focused chemical library is an inevitable necessity for future drug discovery. Natural products have been used as traditional medicines to treat human diseases for millennia; in addition, their molecular scaffolds have been used in diverse approved drugs and drug candidates. The recent discovery of the ability of natural products to inhibit PPIs led us to use natural products as a chemical library for PPI-targeted drug discovery. In this study, we collected natural products (NPDB) from non-commercial and in-house databases to analyze their similarities to small-molecule PPI inhibitors (iPPIs) and FDA-approved drugs by using eight molecular descriptors. Then, we evaluated the distribution of NPDB and iPPIs in the chemical space, represented by the molecular fingerprint and molecular scaffolds, to identify the promising scaffolds, which could interfere with PPIs. To investigate the ability of natural products to inhibit PPI targets, molecular docking was used. Then, we predicted a set of high-potency natural products by using the iPPI-likeness score based on a docking score-weighted model. These selected natural products showed high binding affinities to the PPI target, namely XIAP, which were validated in an in vitro experiment. In addition, the natural products with novel scaffolds might provide a promising starting point for further medicinal chemistry developments. Overall, our study shows the potency of natural products in targeting PPIs, which might help in the design of a PPI-focused chemical library for future drug discovery. Copyright © 2017 Elsevier Inc. All rights reserved.

Translational Researchers' Perceptions of Data Management Practices and Data Curation Needs: Findings from a Focus Group in an Academic Health Sciences Library

ERIC Educational Resources Information Center

Bardyn, Tania P.; Resnick, Taryn; Camina, Susan K.

2012-01-01

How translational researchers use data is becoming an important support function for libraries to understand. Libraries' roles in this increasingly complex area of Web librarianship are often unclearly defined. The authors conducted two focus groups with physicians and researchers at an academic medical center, the UCLA David Geffen School of…

Facility Focus: Libraries.

ERIC Educational Resources Information Center

College Planning & Management, 2003

2003-01-01

Describes the designs of the Ferris State University Library for Information, Technology and Education (FLITE), and the Meyer Library and Information Technology Center at Southwest Missouri State University. Includes photographs. (EV)

Going Global.

ERIC Educational Resources Information Center

Kent, Susan

2002-01-01

Discusses the Bertelsmann Foundation's International Network of Public Libraries which was created to facilitate the exchange of experiences among public library experts, to develop innovative methods of library service, and to promote the implementation of new practices in everyday service. Focuses on libraries in Germany, Scandinavia, and…

Balancing novelty with confined chemical space in modern drug discovery.

PubMed

Medina-Franco, José L; Martinez-Mayorga, Karina; Meurice, Nathalie

2014-02-01

The concept of chemical space has broad applications in drug discovery. In response to the needs of drug discovery campaigns, different approaches are followed to efficiently populate, mine and select relevant chemical spaces that overlap with biologically relevant chemical spaces. This paper reviews major trends in current drug discovery and their impact on the mining and population of chemical space. We also survey different approaches to develop screening libraries with confined chemical spaces balancing physicochemical properties. In this context, the confinement is guided by criteria that can be divided in two broad categories: i) library design focused on a relevant therapeutic target or disease and ii) library design focused on the chemistry or a desired molecular function. The design and development of chemical libraries should be associated with the specific purpose of the library and the project goals. The high complexity of drug discovery and the inherent imperfection of individual experimental and computational technologies prompt the integration of complementary library design and screening approaches to expedite the identification of new and better drugs. Library design approaches including diversity-oriented synthesis, biological-oriented synthesis or combinatorial library design, to name a few, and the design of focused libraries driven by target/disease, chemical structure or molecular function are more efficient if they are guided by multi-parameter optimization. In this context, consideration of pharmaceutically relevant properties is essential for balancing novelty with chemical space in drug discovery.

Espey, Huston & Associates Technical Library. A Proposal.

ERIC Educational Resources Information Center

Fortine, Suellen

This proposal for the establishment of a library or information center for an environmental and engineering consulting firm in Texas is divided into two phases--current problems, and future expansion of library service. Major considerations include informational problems of the existing small library facility, i.e., locational and subject access,…

The Library Macintosh at SCIL [Small Computers in Libraries]'88.

ERIC Educational Resources Information Center

Valauskas, Edward J.; And Others

1988-01-01

The first of three papers describes the role of Macintosh workstations in a library. The second paper explains why the Macintosh was selected for end-user searching in an academic library, and the third discusses advantages and disadvantages of desktop publishing for librarians. (8 references) (MES)

What's Wrong with Library Organization? Factors Leading to Restructuring in Research Libraries.

ERIC Educational Resources Information Center

Hewitt, Joe A.

1997-01-01

Discusses the need for organizational change in academic research libraries, based on a study of a small group of libraries that had experienced varying degrees of restructuring and had analyzed factors that energized change. Highlights include organizational flexibility, external or client-centered orientation, staff empowerment, and improving…

Tourist Attraction: The Moore Library of Lexington, Michigan, 1903-1953

ERIC Educational Resources Information Center

Wiegand, Wayne A.

2011-01-01

This essay challenges traditional assumptions about the small-town American public library and the roles it has played in its community. Conventional thinking and professional rhetoric grounded on a "user in the life of the library" perspective identifies the public library as a neutral agency "essential to democracy" that…

Small-Town Dreamers Build $1.8-Million Community Library.

ERIC Educational Resources Information Center

Fuhr, Sandra

1996-01-01

Describes how the people of Redwood Falls, Minnesota worked together to build a new public library facility in their community. Library personnel and volunteers held various fundraising activities which matched donations from a department store owner and a local grant. Discusses the architecture of the new library which includes computer…

Focus on the Library Customer: Revelation, Revolution, or Redundancy?

ERIC Educational Resources Information Center

Johnson, Diane Tobin

1995-01-01

By examining organizational objectives, the choices librarians make about marketing and customer focus become clearer. Ideas from social marketing reveal that adopting a customer orientation toward marketing may not be right for some libraries. (AEF)

Library Functions, Scholarly Communication, and the Foundation of the Digital Library: Laying Claim to the Control Zone.

ERIC Educational Resources Information Center

Atkinson, Ross

1996-01-01

Discussion of academic libraries and online systems focuses on core library services and a digital library which could serve as an alternative publishing mechanism for specialized scholarly communication. Highlights include adding value to sources of information; conflicts, including those with commercial publishers; and standardization and…

The Role of Technology for the Dallas Public Library in Long Range Planning.

ERIC Educational Resources Information Center

Borgman, Christine L.

Major trends in library technology and technology in general, as indicated by information gathered through internal development work at the Dallas Public Library, professional readings, and interviews with experts, are discussed. Trends covered are: (1) internal library services focusing on a total systems approach to library automation; (2)…

Heroes and Holidays: The Status of Diversity Initiatives at Liberal Arts College Libraries

ERIC Educational Resources Information Center

Gilbert, Julie

2016-01-01

Studies about diversity initiatives in academic libraries have primarily focused on large research libraries. But what kinds of diversity work occur at smaller libraries? This study examines the status of diversity initiatives, especially those aimed at students, at national liberal arts college libraries. Results from a survey of library…

Graphic Novel Collections in Academic ARL Libraries

ERIC Educational Resources Information Center

Wagner, Cassie

2010-01-01

This study examines the extent to which ARL academic libraries collect graphic novels. Using a core list of 176 titles developed from winners of major comics industry awards and a library-focused "best of" list, the holdings of 111 ARL academic libraries were searched using the libraries' online catalogs. Results suggest that most of the…

Libraries in Online Elementary Schools: A Mixed-Methods Study

ERIC Educational Resources Information Center

Hibbard, Laura; Franklin, Teresa

2015-01-01

School libraries serve an important role; however, elementary students who attend schools online typically do not have a school library. This study followed an online school's inaugural year in instituting a library. A mixed methods approach examined data from focus groups, interviews, surveys, library-use records and oral reading fluency scores.…

Beyond Library Power: Reader's Digest Adds Public Libraries to the Mix.

ERIC Educational Resources Information Center

Rockfield, Gary

1998-01-01

Describes the Tall Tree Initiative for Library Services, sponsored by the Reader's Digest Foundation and administered by the public and school library systems of Westchester County, New York. The initiative focuses on improving services offered children in the 21st century, and demands a new level of school-public library cooperation. (AEF)

Leadership Diversity: A Study of Urban Public Libraries

ERIC Educational Resources Information Center

Winston, Mark; Li, Haipeng

2007-01-01

Diversity has been identified as a priority in library and information services for some time. The limited published research on diversity programs in libraries, though, has focused on academic libraries. This article represents the results of a study of leadership diversity in large, urban public libraries. In the study of members of the Urban…

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10.

PubMed

Yang, Wang-Yong; Gao, Rui; Southern, Mark; Sarkar, Partha S; Disney, Matthew D

2016-06-01

RNA is an important target for chemical probes of function and lead therapeutics; however, it is difficult to target with small molecules. One approach to tackle this problem is to identify compounds that target RNA structures and utilize them to multivalently target RNA. Here we show that small molecules can be identified to selectively bind RNA base pairs by probing a library of RNA-focused small molecules. A small molecule that selectively binds AU base pairs informed design of a dimeric compound (2AU-2) that targets the pathogenic RNA, expanded r(AUUCU) repeats, that causes spinocerebellar ataxia type 10 (SCA10) in patient-derived cells. Indeed, 2AU-2 (50 nM) ameliorates various aspects of SCA10 pathology including improvement of mitochondrial dysfunction, reduced activation of caspase 3, and reduction of nuclear foci. These studies provide a first-in-class chemical probe to study SCA10 RNA toxicity and potentially define broadly applicable compounds targeting RNA AU base pairs in cells.

Selected list of Books and Journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1983-01-01

The relationship of the "Selected List" to collection development is explored in the introduction to this revised list of 559 books and 135 journals. The list is intended as a selection guide for the small or medium-sized library in a hospital or comparable medical facility or as a core collection for a consortium of small hospital libraries. Books and journals are categorized by subject; the book list is followed by an author/editor index and the subject list of journals by an alphabetical title listing. Items suggested for initial purchase by smaller libraries (155 books and 54 journals) are indicated by asterisks. To purchase the entire collection of books and to pay for annual subscriptions would require an expenditure of about $38,900. The cost of only the asterisked items totals approximately $13,200. PMID:6190523

Planning Istanbul's Public Library System.

ERIC Educational Resources Information Center

Dokmeci, Vedia; Korca, Perver

1992-01-01

Discussion of the role of public libraries in socioeconomic development focuses on an evaluation of the existing library system in Istanbul (Turkey) and proposes a plan for its balanced development with respect to population distribution and technological advances. Highlights include building design, library automation, and financial…

Virtual Libraries: Service Realities.

ERIC Educational Resources Information Center

Novak, Jan

2002-01-01

Discussion of changes in society that have resulted from information and communication technologies focuses on changes in libraries and a new market for library services with new styles of clients. Highlights client service issues to be considered when transitioning to a virtual library situation. (Author/LRW)

Genetic Diversity of Small Eukaryotes in Lakes Differing by Their Trophic Status

PubMed Central

Lefranc, Marie; Thénot, Aurélie; Lepère, Cécile; Debroas, Didier

2005-01-01

Small eukaryotes, cells with a diameter of less than 5 μm, are fundamental components of lacustrine planktonic systems. In this study, small-eukaryote diversity was determined by sequencing cloned 18S rRNA genes in three libraries from lakes of differing trophic status in the Massif Central, France: the oligotrophic Lake Godivelle, the oligomesotrophic Lake Pavin, and the eutrophic Lake Aydat. This analysis shows that the least diversified library was in the eutrophic lake (12 operational taxonomic units [OTUs]) and the most diversified was in the oligomesotrophic lake (26 OTUs). Certain groups were present in at least two ecosystems, while the others were specific to one lake on the sampling date. Cryptophyta, Chrysophyceae, and the strictly heterotrophic eukaryotes, Ciliophora and fungi, were identified in the three libraries. Among the small eukaryotes found only in two lakes, Choanoflagellida and environmental sequences (LKM11) were not detected in the eutrophic system whereas Cercozoa were confined to the oligomesotrophic and eutrophic lakes. Three OTUs, linked to the Perkinsozoa, were detected only in the Aydat library, where they represented 60% of the clones of the library. Chlorophyta and Haptophyta lineages were represented by a single clone and were present only in Godivelle and Pavin, respectively. Of the 127 clones studied, classical pigmented organisms (autotrophs and mixotrophs) represented only a low proportion regardless of the library's origin. This study shows that the small-eukaryote community composition may differ as a function of trophic status; certain lineages could be detected only in a single ecosystem. PMID:16204507

75 FR 42173 - Small Business Size Standards: Waiver of the Nonmanufacturer Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-20

... Configured Tape Library Storage Equipment. SUMMARY: The U.S. Small Business Administration (SBA) is granting a class waiver of the Nonmanufacturer Rule for Configured Tape Library Storage Equipment, Product... Support Equipment, and PSC 7045 ADP Supplies, under the North American Industry Classification System...

Leisure reading collections in academic health sciences and science libraries: results of visits to seven libraries.

PubMed

Watson, Erin M

2014-03-01

To visit leisure reading collections in academic science and health sciences libraries to determine how they function and what role they play in their libraries. The author visited seven libraries with leisure reading collections and carried out a semistructured interview with those responsible either for selection of materials or for the establishment of the collection. These collections contained a variety of materials, with some libraries focusing on health-science-related materials and others on providing recreational reading. The size of the collections also varied, from 186 to 9700 books, with corresponding differences in budget size. All collections were housed apart, with the same loan period as the regular collection. No collections contained electronic materials. Although there was little comparable statistical data on usage, at the six libraries at which active selection was occurring, librarians and library staff felt that the collection was well used and felt that it provided library users with benefits such as stress relief and relaxation and exposure to other perspectives. Librarians and library staff at the libraries that undertook active selection felt that their leisure reading collection was worthwhile. It would be interesting for future work to focus on the user experience of such collections. © 2013 The author. Health Information and Libraries Journal © 2013 Health Libraries Group.

A Plan for Library Cooperation in Vermont, Report to the Vermont Free Public Library Service.

ERIC Educational Resources Information Center

Little (Arthur D.), Inc., Cambridge, MA.

A survey of library service in Vermont, financed with Library Services and Construction Act funds, was conducted in two parts: (1) an examination of the procedures used by the Free Public Library Service in its role as the focus of interlibrary cooperation in Vermont and an evaluation of library resources in the state and (2) an evaluation of…

Library Research: A Ten Year Analysis of the Library Automation Marketplace: 1981-1990.

ERIC Educational Resources Information Center

Fivecoat, Martha H.

This study focuses on the growth of the library automation market from 1981 to 1990. It draws on library automation data published annually in the Library Journal between 1981 and 1990. The data are used to examine: (1) the overall library system market trends based on the total and cumulative number of systems installed and revenue generated; (2)…

DNA-encoded libraries - an efficient small molecule discovery technology for the biomedical sciences.

PubMed

Kunig, Verena; Potowski, Marco; Gohla, Anne; Brunschweiger, Andreas

2018-06-27

DNA-encoded compound libraries are a highly attractive technology for the discovery of small molecule protein ligands. These compound collections consist of small molecules covalently connected to individual DNA sequences carrying readable information about the compound structure. DNA-tagging allows for efficient synthesis, handling and interrogation of vast numbers of chemically synthesized, drug-like compounds. They are screened on proteins by an efficient, generic assay based on Darwinian principles of selection. To date, selection of DNA-encoded libraries allowed for the identification of numerous bioactive compounds. Some of these compounds uncovered hitherto unknown allosteric binding sites on target proteins; several compounds proved their value as chemical biology probes unraveling complex biology; and the first examples of clinical candidates that trace their ancestry to a DNA-encoded library were reported. Thus, DNA-encoded libraries proved their value for the biomedical sciences as a generic technology for the identification of bioactive drug-like molecules numerous times. However, large scale experiments showed that even the selection of billions of compounds failed to deliver bioactive compounds for the majority of proteins in an unbiased panel of target proteins. This raises the question of compound library design.

Development of hydrogel TentaGel shell-core beads for ultrahigh throughput solution-phase screening of encoded OBOC combinatorial small molecule libraries.

PubMed

Baek, Hyoung Gee; Liu, Ruiwu; Lam, Kit S

2009-01-01

The one-bead one-compound (OBOC) combinatorial library method enables the rapid generation and screening of millions of discrete chemical compounds on beads. Most of the OBOC screening methods require the library compounds to remain tethered to the bead during screening process. Methods have also been developed to release library compounds from immobilized beads for in situ solution phase or "lawn" assays. However, this latter approach, while extremely powerful, is severely limited by the lack of suitable solid supports for such assays. Here, we report on the development of a novel hydrogel TentaGel shell-core (HTSC) bead in which hydrogel is grafted onto the polystyrene-based TentaGel (TG) bead as an outer shell (5-80 mum thick) via free radical surface-initiated polymerization. This novel shell-core bilayer resin enables the preparation of encoded OBOC combinatorial small molecule libraries, such that the library compounds reside on the highly hydrophilic outer layer and the coding tags reside in the polystyrene-based TG core. Using fluorescein as a model small molecule compound, we have demonstrated that fluorescein molecules that have been linked covalently to the hydrogel shell via a disulfide bond could readily diffuse out of the hydrogel layer into the bead surrounding after reduction with dithiothreitol. In contrast, under identical condition, the released fluorescein molecules remained bound to unmodified TG bead. We have prepared an encoded OBOC small molecule library on the novel shell-core beads and demonstrated that the beads can be readily decoded.

Architectural Optimization of Digital Libraries

NASA Technical Reports Server (NTRS)

Biser, Aileen O.

1998-01-01

This work investigates performance and scaling issues relevant to large scale distributed digital libraries. Presently, performance and scaling studies focus on specific implementations of production or prototype digital libraries. Although useful information is gained to aid these designers and other researchers with insights to performance and scaling issues, the broader issues relevant to very large scale distributed libraries are not addressed. Specifically, no current studies look at the extreme or worst case possibilities in digital library implementations. A survey of digital library research issues is presented. Scaling and performance issues are mentioned frequently in the digital library literature but are generally not the focus of much of the current research. In this thesis a model for a Generic Distributed Digital Library (GDDL) and nine cases of typical user activities are defined. This model is used to facilitate some basic analysis of scaling issues. Specifically, the calculation of Internet traffic generated for different configurations of the study parameters and an estimate of the future bandwidth needed for a large scale distributed digital library implementation. This analysis demonstrates the potential impact a future distributed digital library implementation would have on the Internet traffic load and raises questions concerning the architecture decisions being made for future distributed digital library designs.

Cell targeting peptides as smart ligands for targeting of therapeutic or diagnostic agents: a systematic review.

PubMed

Mousavizadeh, Ali; Jabbari, Ali; Akrami, Mohammad; Bardania, Hassan

2017-10-01

Cell targeting peptides (CTP) are small peptides which have high affinity and specificity to a cell or tissue targets. They are typically identified by using phage display and chemical synthetic peptide library methods. CTPs have attracted considerable attention as a new class of ligands to delivery specifically therapeutic and diagnostic agents, because of the fact they have several advantages including easy synthesis, smaller physical sizes, lower immunogenicity and cytotoxicity and their simple and better conjugation to nano-carriers and therapeutic or diagnostic agents compared to conventional antibodies. In this systematic review, we will focus on the basic concepts concerning the use of cell-targeting peptides (CTPs), following the approaches of selecting them from peptide libraries. We discuss several developed strategies for cell-specific delivery of different cargos by CTPs, which are designed for drug delivery and diagnostic applications. Copyright © 2017 Elsevier B.V. All rights reserved.

Peregrine: A rapid and unbiased method to produce strand-specific RNA-Seq libraries from small quantities of starting material.

PubMed

Langevin, Stanley A; Bent, Zachary W; Solberg, Owen D; Curtis, Deanna J; Lane, Pamela D; Williams, Kelly P; Schoeniger, Joseph S; Sinha, Anupama; Lane, Todd W; Branda, Steven S

2013-04-01

Use of second generation sequencing (SGS) technologies for transcriptional profiling (RNA-Seq) has revolutionized transcriptomics, enabling measurement of RNA abundances with unprecedented specificity and sensitivity and the discovery of novel RNA species. Preparation of RNA-Seq libraries requires conversion of the RNA starting material into cDNA flanked by platform-specific adaptor sequences. Each of the published methods and commercial kits currently available for RNA-Seq library preparation suffers from at least one major drawback, including long processing times, large starting material requirements, uneven coverage, loss of strand information and high cost. We report the development of a new RNA-Seq library preparation technique that produces representative, strand-specific RNA-Seq libraries from small amounts of starting material in a fast, simple and cost-effective manner. Additionally, we have developed a new quantitative PCR-based assay for precisely determining the number of PCR cycles to perform for optimal enrichment of the final library, a key step in all SGS library preparation workflows.

The Marine Corps University Library.

ERIC Educational Resources Information Center

Ramkey, Carol E.

2001-01-01

Describes the Marine Corps University (Virginia) Library's collections and reserves. States that the library's resources focus on military doctrine, history, arts, and sciences, and that they include Web- and CD-ROM-based specialized military databases. Describes the library's mission to serve the university community and Marine Corps patrons…

Teaching the Library at SIBL.

ERIC Educational Resources Information Center

Thornton, Ann

1999-01-01

Describes the curriculum of free training courses offered at the New York Public Library Science, Industry and Business Library (SIBL) that focus on information-seeking skills and information literacy. Classes offered include basic library skills, Internet and World Wide Web, business information, government information, and science information.…

South Dakota State University's Library: A History. Hilton M. Briggs Library Occasional Paper Number 1.

ERIC Educational Resources Information Center

Brown, Philip

Tracing the history of South Dakota State University's Hilton M. Briggs Library over the past 102 years, this occasional paper describes the development of what is now the largest library (over 1.1 million total pieces) in the South Dakota Library Network from its inception as part of a small land grant college. Administrative eras are reviewed,…

Alabama Public Library Service, The State Library Agency. 1986 Annual Report.

ERIC Educational Resources Information Center

Alabama Public Library Service, Montgomery.

Designed to provide an overview of the range and quality of services provided by the Alabama Public Library Service (APLS), this annual report focuses on the 1986 activities of APLS; the state's public library directory and statistical report will be published separately. A discussion of the activities of the Library Development Division includes…

[The Andrew Heiskell Library for the Blind and Physically Handicapped.] A Library with a Difference. Projects and Experiments.

ERIC Educational Resources Information Center

Jarkon, Joe; Fitzpatrick, Vicki, Ed.

This publication describes the Andrew Heiskell Library for the Blind and Physically Handicapped, a regional library for the National Library Service (NLS) example of the creative use of physical space and innovative technology. The publication focuses on the materials-handling system designed for the new facility, including system design…

Library Spaces for 21st-Century Learners: A Planning Guide for Creating New School Library Concepts

ERIC Educational Resources Information Center

Sullivan, Margaret

2013-01-01

"Library Spaces for 21st-Century Learners: A Planning Guide for Creating New School Library Concepts" focuses on planning contemporary school library spaces with user-based design strategies. The book walks school librarians and administrators through the process of gathering information from students and other stakeholders involved in…

Creating an Engaging Library Orientation: First Year Experience Courses at UC San Diego

ERIC Educational Resources Information Center

Goldman, Crystal; Turnbow, Dominique; Roth, Amanda; Friedman, Lia; Heskett, Karen

2016-01-01

This article focuses on the development of an engaging library orientation module for UC San Diego First Year Experience (FYE) courses. The library module included a brief in-class presentation about research concepts and library services, an online interactive library scavenger hunt given as an in-class activity, and a homework assignment where…

The Physical Accessibility of Public Libraries to Users: A GIS Study

ERIC Educational Resources Information Center

Park, Sung Jae

2011-01-01

The purpose of this study is to gain a finer-grained picture and better understanding of the travel patterns of library users, and the activities, demographics, and other factors that affect library access. Previous studies of physical accessibility of public libraries, which have focused on library users' single-destination trips and their travel…

A Student-Focused Usability Study of the Western Michigan University Libraries Home Page

ERIC Educational Resources Information Center

Whang, Michael; Ring, Donna M.

2007-01-01

Three sources indicated the need for designing a usability study of the Western Michigan University Libraries' Web site: the results of the 2004 LibQUAL+ survey; the completion of the library's new strategic planning document; and suggestions by library customers and library staff. LibQUAL+ findings and customer comments suggested customers…

Data Management inside the Library: Assessing Electronic Resources Data Using the Data Asset Framework Methodology

ERIC Educational Resources Information Center

Ogier, Andi; Hall, Monena; Bailey, Annette; Stovall, Connie

2014-01-01

Rapidly growing within academic libraries, library data services have often been focused on assessing research trends and building partnerships outside the library. There are distinct benefits, however, to using data audit methodologies created for these external assessments of researcher practices inside the library as well. In this article, we…

What Qualifications and Skills Are Important for Digital Librarian Positions in Academic Libraries? A Job Advertisement Analysis

ERIC Educational Resources Information Center

Choi, Youngok; Rasmussen, Edie

2009-01-01

As academic library functions and activities continue to evolve, libraries have broadened the traditional library model, which focuses on management of physical resources and activities, to include a digital library model, transforming resources and services into digital formats to support teaching, learning, and research. This transition has…

IFLA General Conference, 1987. Division of Management and Technology. Library Building and Equipment Section. Information Technology Section. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

The six papers in this collection focus on library buildings and equipment and information technology: (1) "Library Equipment in a Changing Library Environment" (Margaret Beckman, Canada); (2) "The New Building for the British Library" (Colin St. John Wilson, United Kingdom); (3) "User Interaction with Online Catalogue" (Stephen Walker, United…

Open Source Library Management Systems: A Multidimensional Evaluation

ERIC Educational Resources Information Center

Balnaves, Edmund

2008-01-01

Open source library management systems have improved steadily in the last five years. They now present a credible option for small to medium libraries and library networks. An approach to their evaluation is proposed that takes account of three additional dimensions that only open source can offer: the developer and support community, the source…

Wisconsin Library Trustee Reference Manual.

ERIC Educational Resources Information Center

Opinion Research Corp., Princeton, NJ.

This newly updated and revised expansion of the Wisconsin Library Trustee's Manual serves as a comprehensive resource and how-to guide for board members of public libraries that range in size and scope from small to large communities in both urban and rural areas. The manual includes basic information to which every Wisconsin library trustee…

Special Libraries: Planning and Operation; Preliminary Draft.

ERIC Educational Resources Information Center

Weiner, Betty H.

An attempt is made in this report to combine a pragmatic how-to-do-it approach with suggestions for applying system analysis techniques for planning and operating a small special library or information center. A special library is defined as a library in a commercial, industrial, governmental or non-profit organization such as research…

La Administracion de las Bibliotecas Escolares (School Library Administration). IFLA Professional Reports, No. 29.

ERIC Educational Resources Information Center

Galler, Anne M.; Coulter, Joan M.

This manual provides practical information on the planning, organization, and operation of school libraries. Some of the guidelines differentiate between small libraries with minimal collections and larger, better-equipped libraries with more resources. Introductory materials include definitions of terms used in this manual. Guidelines are then…

Vermont Public Library Almanac: A Compendium of Often-Answered Questions. 2nd Edition.

ERIC Educational Resources Information Center

Kotch, Marianne

This document contains brief answers to some of the most frequently raised issues related to running a small Vermont public library. Areas covered include accessibility, the American Library Association, automation, awards, binding, services for the blind and physically handicapped, the Board of Libraries, the Board of Trustees, book dealers, book…

Small Libraries Online: Automating Circulation and Public Access Catalogs. Revised and Updated.

ERIC Educational Resources Information Center

Peterson, Christine

This manual provides information to help libraries in Texas considering an automation project, with special emphasis on smaller libraries. The solutions discussed are microcomputer-based. The manual begins with a discussion of how to prepare for the automation of a library, including planning, approval, collection decisions, policy, and staffing.…

A Study of the Subject Headings Practices of Fifteen Small Liberal Arts College Libraries.

ERIC Educational Resources Information Center

Kissel, Laura J.

This research was conducted in order to examine whether libraries are maintaining consistent and complete subject authority control and creating syndetic reference structure for popular topics. A descriptive study of 15 private liberal arts college libraries was conducted to determine whether the Library of Congress (LC) prescribed "see"…

Applications of SHAPES screening in drug discovery.

PubMed

Lepre, Christopher A; Peng, Jeffrey; Fejzo, Jasna; Abdul-Manan, Norzehan; Pocas, Jennifer; Jacobs, Marc; Xie, Xiaoling; Moore, Jonathan M

2002-12-01

The SHAPES strategy combines nuclear magnetic resonance (NMR) screening of a library of small drug-like molecules with a variety of complementary methods, such as virtual screening, high throughput enzymatic assays, combinatorial chemistry, X-ray crystallography, and molecular modeling, in a directed search for new medicinal chemistry leads. In the past few years, the SHAPES strategy has found widespread utility in pharmaceutical research. To illustrate a variety of different implementations of the method, we will focus in this review on recent applications of the SHAPES strategy in several drug discovery programs at Vertex Pharmaceuticals.

Safeguarding Digital Library Contents: Charging for Online Content.

ERIC Educational Resources Information Center

Herzberg, Amir

1998-01-01

Investigates the need for mechanisms for charging by digital libraries and other providers of online content, in particular for micropayments, i.e., charging for small amounts. The SSL (Secure Socket Layer) and SET (Secure Electronic Transactions) protocols for charge card payments and the MiniPay micropayment mechanism for charging small amounts…

Small Libraries Online: Automating Circulation and Public Access Catalogs. Participant Workbook.

ERIC Educational Resources Information Center

Garcia, C. Rebecca; Bridge, Frank R.

This workbook, meant to be used in a workshop, presents information on and guidelines for automating small libraries: (1) planning for automation; (2) automated system procurement and evaluation; (3) data conversion issues; (4) sample configuration worksheets; (5) sample configuration costs; (6) site preparation; (7) training; and (8) acceptance…

75 FR 32231 - Small Business Size Standards: Waiver of the Nonmanufacturer Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

... for configured tape library storage equipment. SUMMARY: The U.S. Small Business Administration (SBA... Storage Equipment. SBA is initiating a request that an class waiver be granted for Configured Tape Library Storage Equipment, Product Service Code (PSC) 7025 Automated Data Processing (ADP) Input/ Output and...

Screening of Small Molecule Interactor Library by Using In-Cell NMR Spectroscopy (SMILI-NMR)

PubMed Central

Xie, Jingjing; Thapa, Rajiv; Reverdatto, Sergey; Burz, David S.; Shekhtman, Alexander

2011-01-01

We developed an in-cell NMR assay for screening small molecule interactor libraries (SMILI-NMR) for compounds capable of disrupting or enhancing specific interactions between two or more components of a biomolecular complex. The method relies on the formation of a well-defined biocomplex and utilizes in-cell NMR spectroscopy to identify the molecular surfaces involved in the interaction at atomic scale resolution. Changes in the interaction surface caused by a small molecule interfering with complex formation are used as a read-out of the assay. The in-cell nature of the experimental protocol insures that the small molecule is capable of penetrating the cell membrane and specifically engaging the target molecule(s). Utility of the method was demonstrated by screening a small dipeptide library against the FKBP–FRB protein complex involved in cell cycle arrest. The dipeptide identified by SMILI-NMR showed biological activity in a functional assay in yeast. PMID:19422228

Personalized Information Environments: Do Public Libraries Want a Slice of the PIE?

ERIC Educational Resources Information Center

Worcester, Lea

2003-01-01

Discussion of personalized information environments (PIEs) focuses on library personalized interfaces. Describes academic library PIEs and commercial sites, such as Amazon.com that use personalization; explores the Public Library of Charlotte and Mecklenburg's personalized interface; and discusses opportunities and challenges PIEs offer public…

Libraries and Literacy in Ecological Perspective

ERIC Educational Resources Information Center

Sensenig, Victor J.

2012-01-01

This study investigated the nature of the literacy environment that public libraries construct and how they share the project of children's literacy development with homes and schools. It focuses on library programs for children, particularly story times. Its data came from observations of library activities, interviews with librarians and…

The Value of Research in Academic Libraries

ERIC Educational Resources Information Center

Perkins, Gay Helen; Slowik, Amy J. W.

2013-01-01

In the summer of 2010, two researchers interviewed twenty-three library administrators of comparable academic libraries at American universities for their views of the value of research in academic libraries. The interview questions focused on the administrators' perceived value of academic librarians' research, incentives given to academic…

Toward an Intellectual Freedom Theory for Users of Libraries.

ERIC Educational Resources Information Center

Berninghausen, David K.

1982-01-01

Considers theories of intellectual freedom for library users, focusing on policies and practices which have developed in publicly supported libraries in America in the late twentieth century. Related legislation is discussed, including the First Amendment and Library Bill of Rights. Twenty-six references are cited. (EJS)

Collection Management: Electronically-Delivered Information.

ERIC Educational Resources Information Center

Trawick, Theresa C.; And Others

Issues in the management of library collections of electronically delivered information are discussed, focusing on the library at Troy State University (Alabama). Because of the library's selective depository status, expensive compact disk-read only memory (CD-ROM) products are received, which the library could not normally afford. At the Troy…

Chemoinformatic Analysis of Combinatorial Libraries, Drugs, Natural Products and Molecular Libraries Small Molecule Repository

PubMed Central

Singh, Narender; Guha, Rajarshi; Giulianotti, Marc; Pinilla, Clemencia; Houghten, Richard; Medina-Franco, Jose L.

2009-01-01

A multiple criteria approach is presented, that is used to perform a comparative analysis of four recently developed combinatorial libraries to drugs, Molecular Libraries Small Molecule Repository (MLSMR) and natural products. The compound databases were assessed in terms of physicochemical properties, scaffolds and fingerprints. The approach enables the analysis of property space coverage, degree of overlap between collections, scaffold and structural diversity and overall structural novelty. The degree of overlap between combinatorial libraries and drugs was assessed using the R-NN curve methodology, which measures the density of chemical space around a query molecule embedded in the chemical space of a target collection. The combinatorial libraries studied in this work exhibit scaffolds that were not observed in the drug, MLSMR and natural products collections. The fingerprint-based comparisons indicate that these combinatorial libraries are structurally different to current drugs. The R-NN curve methodology revealed that a proportion of molecules in the combinatorial libraries are located within the property space of the drugs. However, the R-NN analysis also showed that there are a significant number of molecules in several combinatorial libraries that are located in sparse regions of the drug space. PMID:19301827

Towards a Worldwide Library: A Ten Year Forecast. Proceedings of the International Essen Symposium (19th, Essen, Germany, September 23-26, 1996). Publications of Essen University Library, No. 21.

ERIC Educational Resources Information Center

Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

The 25 papers presented at this symposium focus on the future of libraries and library services in an ever evolving Information Age. The papers deal with topics such as: economic and political issues in determining the future of the professionally managed library; adding value to library services; the need for librarians and library educators who…

Focus on Customer Service. Service Management: How to Plan for it Rather Than Hope for It [and] Learning to Say "Yes": A Customer Service Program for Library Staff [and] Maintaining Momentum in a Quality Improvement Process.

ERIC Educational Resources Information Center

Brewer, Julie; And Others

1995-01-01

Presents three articles that discuss customer service in libraries, with a focus on planning for service management, a customer service program for library staff, and a quality improvement process. Highlights include developing and implementing service strategies, dealing with requests, redefining work relationships, coworkers as customers,…

Impact of New Nuclear Data Libraries on Small Sized Long Life CANDLE HTGR Design Parameters

NASA Astrophysics Data System (ADS)

Liem, Peng Hong; Hartanto, Donny; Tran, Hoai Nam

2017-01-01

The impact of new evaluated nuclear data libraries (JENDL-4.0, ENDF/B-VII.0 and JEFF-3.1) on the core characteristics of small-sized long-life CANDLE High Temperature Gas-Cooled Reactors (HTGRs) with uranium and thorium fuel cycles was investigated. The most important parameters of the CANDLE core characteristics investigated here covered (1) infinite multiplication factor of the fresh fuel containing burnable poison, (2) the effective multiplication factor of the equilibrium core, (3) the moving velocity of the burning region, (4) the attained discharge burnup, and (5) the maximum power density. The reference case was taken from the current JENDL-3.3 results. For the uranium fuel cycle, the impact of the new libraries was small, while significant impact was found for thorium fuel cycle. The findings indicated the needs of more accurate nuclear data libraries for nuclides involved in thorium fuel cycle in the future.

Making the Link between Libraries and Adult Basic Skills.

ERIC Educational Resources Information Center

Clarke, Genevieve

2002-01-01

Vital Link is a British program that links national reading and literacy organizations with libraries. The focus is on how libraries can support and motivate existing learners while attracting new learners. (JOW)

Team effectiveness in academic medical libraries: a multiple case study*

PubMed Central

Russo Martin, Elaine

2006-01-01

Objectives: The objective of this study is to apply J. Richard Hackman's framework on team effectiveness to academic medical library settings. Methods: The study uses a qualitative, multiple case study design, employing interviews and focus groups to examine team effectiveness in three academic medical libraries. Another site was selected as a pilot to validate the research design, field procedures, and methods to be used with the cases. In all, three interviews and twelve focus groups, with approximately seventy-five participants, were conducted at the case study libraries. Findings: Hackman identified five conditions leading to team effectiveness and three outcomes dimensions that defined effectiveness. The participants in this study identified additional characteristics of effectiveness that focused on enhanced communication, leadership personality and behavior, and relationship building. The study also revealed an additional outcome dimension related to the evolution of teams. Conclusions: Introducing teams into an organization is not a trivial matter. Hackman's model of effectiveness has implications for designing successful library teams. PMID:16888659

Tomorrow's Research Library: Vigor or Rigor Mortis?

ERIC Educational Resources Information Center

Hacken, Richard D.

1988-01-01

Compares, contrasts, and critiques predictions that have been made about the future of research libraries, focusing on the impact of technology on the library's role and users' needs. The discussion includes models for the adaptation of new technologies that may assist in library planning and change. (38 references) (CLB)

The Recognition of Depreciation of Library Materials.

ERIC Educational Resources Information Center

Carpenter, Michael; Millican, Rita

1991-01-01

Discussion of the depreciation of assets for nonprofit organizations focuses on a study conducted at the Louisiana State University Law Library to determine the cost basis for depreciation of library materials. Determining the useful life of the library materials is described and various methods of depreciation are explained. (five references)…

Services to Remote Users: Marketing the Library's Role.

ERIC Educational Resources Information Center

Wolpert, Ann

1998-01-01

Discussion of the impact of distance education on academic libraries focuses on marketing aspects. Topics include the rapid expansion of educational computing; the maturing of higher education; the World Wide Web as competitor to academic libraries; business purposes of academic libraries; distance education strategies; servicing market segments;…

Information Policy -- Distance Education: Provider and Victim Libraries.

ERIC Educational Resources Information Center

Heron, Peter; Dugan, Robert E.

1997-01-01

This discussion of information policy focuses on library services for distance education. Topics include the logistics and management of providing library services off-site and/or responding to student requests; and meeting the needs of distance education students for information and library instruction, both students from the member institution…

Collaborative Collections Management Programs in ARL Libraries. SPEC Kit 235.

ERIC Educational Resources Information Center

Soete, George J., Comp.

1998-01-01

This survey was conducted to discover how extensively ARL (Association of Research Libraries) libraries are involved in formal, active programs of collaboration for collections management. Seventy ARL libraries completed a questionnaire focusing on all collections formats and a number of related collections management activities. Results indicated…

A Truly Bookless Library

ERIC Educational Resources Information Center

Kolowich, Steve

2011-01-01

The difference between the University of Texas at San Antonio's Applied Engineering and Technology Library and other science-focused libraries is not that its on-site collection is also available electronically. It is that its on-site collection is only available electronically. The idea of libraries with no bound books has been a recurring theme…

Academic Utilization of Government Publications in Three Nigerian University Libraries

ERIC Educational Resources Information Center

Okwor, Roseline Ngozi; Mole, Austin J. C.; Ihekwoaba, Emmanuel Chukwudi

2015-01-01

This paper seeks to examine the current state of academic utilization of government publications in Nigerian university libraries. Using a descriptive survey, the study focused on three academic libraries in Southeastern Nigeria serving a population of 11,996 undergraduate and postgraduate student library users, 592 of whom answered a…

Intellectual Freedom and Censorship in the Library

ERIC Educational Resources Information Center

Cooper, Jessica L.

2010-01-01

The article gives a brief description of intellectual freedom and censorship in order to set a foundation for looking into the library community's role in advocating for intellectual freedom and combating censorship. Focus is given to the unique challenges of school libraries in fulfilling the larger library community's expectations in these two…

Accessibility Trends among Academic Library and Library School Web Sites in the USA and Canada

ERIC Educational Resources Information Center

Schmetzke, Axel; Comeaux, David

2009-01-01

This paper focuses on the accessibility of North American library and library school Web sites for all users, including those with disabilities. Web accessibility data collected in 2006 are compared to those of 2000 and 2002. The findings of this follow-up study continue to give cause for concern: Despite improvements since 2002, library and…

Engaging with Clients and Personalising Services at UTS Library: Measuring the Value for Libraries and Their Clients

ERIC Educational Resources Information Center

Tiffen, Belinda; England, Ashley

2011-01-01

Libraries have found themselves overtaken by commercial entities providing open, unmediated information services, causing debate about the future of libraries. It has been argued that in order to stay relevant, libraries must undertake a fundamental shift towards a new focus on engaging with clients. At University of Technology, Sydney (UTS)…

Revealing Library Collections: NSLA Re-Imagining Libraries Project 8--Description and Cataloguing

ERIC Educational Resources Information Center

Gatenby, Pam

2010-01-01

One of the most exciting developments to occur within the library profession in recent years has been the re-evaluation of library's role in resource discovery in the web environment. This has involved recognition of short-comings of online library catalogues, a re-affirmation of the importance of metadata and a new focus on the wealth of…

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N; Hill, D R

1995-04-01

The complementary informational access roles of the traditional hospital library book and journal collection and the high-tech Internet are viewed from a 1995 perspective. Predecessors of this list have been intended as selection guides for a small or medium-size library in a hospital or comparable medical facility. As the prices of books and journals continue on an upward spiral, the secondary purpose as a core collection for a consortium of small hospital libraries or a network sharing library resources is fast becoming its primary use. Books (610) and journals (141) are categorized by subject; the book list is followed by an author/editor index and the subject list of journals by an alphabetical title listing. Due to requests from librarians, a "minimal core" book collection consisting of 82 titles has been pulled out from the 200 asterisked initial-purchase books. To purchase the entire collection of books and to pay for 1995 subscriptions would require $93,300. The cost of only the asterisked items totals $39,000. The "minimal core" book collection costs $12,700.

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1995-01-01

The complementary informational access roles of the traditional hospital library book and journal collection and the high-tech Internet are viewed from a 1995 perspective. Predecessors of this list have been intended as selection guides for a small or medium-size library in a hospital or comparable medical facility. As the prices of books and journals continue on an upward spiral, the secondary purpose as a core collection for a consortium of small hospital libraries or a network sharing library resources is fast becoming its primary use. Books (610) and journals (141) are categorized by subject; the book list is followed by an author/editor index and the subject list of journals by an alphabetical title listing. Due to requests from librarians, a "minimal core" book collection consisting of 82 titles has been pulled out from the 200 asterisked initial-purchase books. To purchase the entire collection of books and to pay for 1995 subscriptions would require $93,300. The cost of only the asterisked items totals $39,000. The "minimal core" book collection costs $12,700. PMID:7599581

A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships.

PubMed

Mathew, Bini; Snowden, Timothy S; Connelly, Michele C; Guy, R Kiplin; Reynolds, Robert C

2018-05-10

Non-steroidal anti-inflammatory drugs (NSAIDs) have a variety of potential indications that include management of pain and inflammation as well as chemoprevention and/or treatment of cancer. Furthermore, a specific form of ibuprofen, dexibuprofen or the S-(+) form, shows interesting neurological activities and has been proposed for the treatment of Alzheimer's disease. In a continuation of our work probing the anticancer activity of small sulindac libraries, we have prepared and screened a small diversity library of α-methyl substituted sulindac amides in the profen class. Several compounds of this series displayed promising activity compared with a lead sulindac analog. Copyright © 2018. Published by Elsevier Ltd.

Library Intranets: Trends and Enhancements

ERIC Educational Resources Information Center

Thomas, Lisa Carlucci

2010-01-01

Libraries are widely known as institutions that access, organize, and preserve collections of information. Libraries are also dynamic administrative entities that generate and exchange internal business information. From small operations with limited staff and technology to large, multidepartmental institutions with full IT support, libraries…

Life in the Cloud: A WorldShare Management Services Case Study

ERIC Educational Resources Information Center

Hartman, Robin R.

2012-01-01

A small, private academic library took the risk of moving from a traditional integrated library system to adopting a system "in the cloud." This case study presents the setting, history, and local needs of the library, including staffing challenges, and explains the decision-making rationale and process. A description of the library's transition…

A Model for Service to the Elderly by the Small/Medium Sized Public Library.

ERIC Educational Resources Information Center

Jeffries, Stephen R.

Citing the American Library Association's 1964 statement of libraries' responsibilities to the aging, this paper presents a needs assessment of the elderly and suggests methods by which public libraries can attempt to meet some of these needs, e.g., barrier-free design, programs, materials, and services. The needs assessment of older users…

Education and Outreach Programs at the Reagan Library.

ERIC Educational Resources Information Center

Cumming, Gregory G.

This exploration of the need and potential for education and outreach programs at the Reagan Library begins by examining factors that make the Reagan library unique, i.e., its proximity to Los Angeles and a small town setting, closeness to the Nixon Library and birthplace, and Ronald Reagan's popularity. It is noted that, since the Reagan Library…

Best Small Library in America 2009: Union County Carnegie Library, SC--Carolina Dreaming

ERIC Educational Resources Information Center

Berry, John N., III

2009-01-01

In the past three years, the Union County Carnegie Library (UCCL) in South Carolina has "been transformed." The library board, selected by the county supervisors, knew something had to be done. In October 2005, the board hired Nancy E. Rosenwald as UCCL director. Longing to get back to South Carolina from western Connecticut, Rosenwald…

International Reports.

ERIC Educational Resources Information Center

Anderson, Nancy D.; And Others

1994-01-01

Three reports discuss the International Federation of Library Associations and Institutions; the Frankfurt Book Fair, focusing on electronics; and Canadian library trends, including resource sharing, technology projects, information policy, censorship, services for persons with disabilities, construction projects, and library education and…

Case study: library usage at an Indian medical college.

PubMed

Shah, Chinmay

2011-03-01

This issue's feature column reports on the findings of a small survey of library users carried out in an Indian medical college with a traditional curriculum. The study found that the main reason a student visited the library was to consult text books. Although the majority of students were satisfied with the library facilities, the study suggests that more needs to be done to promote self-directed learning. JM. © 2010 The authors. Health Information and Libraries Journal © 2010 Health Libraries Group.

Structural interaction fingerprints: a new approach to organizing, mining, analyzing, and designing protein-small molecule complexes.

PubMed

Singh, Juswinder; Deng, Zhan; Narale, Gaurav; Chuaqui, Claudio

2006-01-01

The combination of advances in structure-based drug design efforts in the pharmaceutical industry in parallel with structural genomics initiatives in the public domain has led to an explosion in the number of structures of protein-small molecule complexes structures. This information has critical importance to both the understanding of the structural basis for molecular recognition in biological systems and the design of better drugs. A significant challenge exists in managing this vast amount of data and fully leveraging it. Here, we review our work to develop a simple, fast way to store, organize, mine, and analyze large numbers of protein-small molecule complexes. We illustrate the utility of the approach to the management of inhibitor complexes from the protein kinase family. Finally, we describe our recent efforts in applying this method to the design of target-focused chemical libraries.

Recommended Reference Books for Small and Medium-Sized Libraries and Media Centers, 1998.

ERIC Educational Resources Information Center

Wynar, Bohdan S., Ed.

This annual review source is designed to assist smaller libraries in the systematic selection of suitable reference materials for their collections. Approximately 500 unabridged reviews, written by over 250 practicing librarians and subject specialists, identify and describe the most useful and affordable reference sources available for small and…

UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small molecule natural product libraries

USDA-ARS?s Scientific Manuscript database

Generation of natural product libraries containing column fractions, each with only a few small molecules, by a high throughput, automated fractionation system has made it possible to implement an improved dereplication strategy for selection and prioritization of hits in a natural product discovery...

Selected List of Books and Journals for the Small Medical Library

PubMed Central

Brandon, Alfred N.

1965-01-01

This list of 358 books and 123 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. PMID:14308899

Administration of the Small Public Library. Fourth Edition.

ERIC Educational Resources Information Center

Weingand, Darlene E.

Since the publication of its first edition in 1965, this book has been a standard resource for setting up and managing cutting-edge small public library facilities. Completely revised and updated, this fourth edition continues that tradition with many more figures (28 in this edition), case studies and sample policies, and new content on grant…

Regional Information Centers: A Frontier in Small Library Automation. Dissemination Document No. 12.

ERIC Educational Resources Information Center

Oldsen, Carl F.; Vinsonhaler, John F.

The regional information center is examined as an instrument for innovation in small library automation and as a basis for the evolution of national information systems. Summarized is development of regional information centers in education, including centers specially for handicapped children, and indicated are trends toward national information…

Selected List of Books and Journals for the Small Medical Library

PubMed Central

Brandon, Alfred N.

2012-01-01

This list of 358 books and 123 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. PMID:23509428

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N

1967-04-01

This updated list of 388 books and 140 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing.

SELECTED LIST OF BOOKS AND JOURNALS FOR THE SMALL MEDICAL LIBRARY.

PubMed

BRANDON, A N

1965-07-01

This list of 358 books and 123 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing.

Integrated Platform for Expedited Synthesis–Purification–Testing of Small Molecule Libraries

PubMed Central

2017-01-01

The productivity of medicinal chemistry programs can be significantly increased through the introduction of automation, leading to shortened discovery cycle times. Herein, we describe a platform that consolidates synthesis, purification, quantitation, dissolution, and testing of small molecule libraries. The system was validated through the synthesis and testing of two libraries of binders of polycomb protein EED, and excellent correlation of obtained data with results generated through conventional approaches was observed. The fully automated and integrated platform enables batch-supported compound synthesis based on a broad array of chemical transformations with testing in a variety of biochemical assay formats. A library turnaround time of between 24 and 36 h was achieved, and notably, each library synthesis produces sufficient amounts of compounds for further evaluation in secondary assays thereby contributing significantly to the shortening of medicinal chemistry discovery cycles. PMID:28435537

A kinase-focused compound collection: compilation and screening strategy.

PubMed

Sun, Dongyu; Chuaqui, Claudio; Deng, Zhan; Bowes, Scott; Chin, Donovan; Singh, Juswinder; Cullen, Patrick; Hankins, Gretchen; Lee, Wen-Cherng; Donnelly, Jason; Friedman, Jessica; Josiah, Serene

2006-06-01

Lead identification by high-throughput screening of large compound libraries has been supplemented with virtual screening and focused compound libraries. To complement existing approaches for lead identification at Biogen Idec, a kinase-focused compound collection was designed, developed and validated. Two strategies were adopted to populate the compound collection: a ligand shape-based virtual screening and a receptor-based approach (structural interaction fingerprint). Compounds selected with the two approaches were cherry-picked from an existing high-throughput screening compound library, ordered from suppliers and supplemented with specific medicinal compounds from internal programs. Promising hits and leads have been generated from the kinase-focused compound collection against multiple kinase targets. The principle of the collection design and screening strategy was validated and the use of the kinase-focused compound collection for lead identification has been added to existing strategies.

Engaging Communities using a MOOC combined with Public Library Discussions

NASA Astrophysics Data System (ADS)

Ackerman, S. A.; Mooney, M. E.; Morrill, J.; Handlos, Z.; Morrill, S.

2015-12-01

A massive open online course, or MOOC, is an noncredit education activity that delivers learning content to anyone with access to the Internet. Individual courses are generally free of charge, while a certificate can have small costs. The University of Wisconsin-Madison has exploring the use of MOOC as part of its Wisconsin Idea. In the 2015, a series of MOOCs focusing on the environment were offered via Coursera. One of those MOOCS was "Changing Weather and Climate of the Great Lakes Region." This 4-week course features a new season each week through short lectures and activities covering Great Lakes weather, observed changes in the climate, and societal impacts of climate change. (https://www.coursera.org/course/greatlakesclimate) The MOOC conveyed information from NOAA's National Weather Service (NWS) Weather-Ready Nation initiative as well as findings from the recent National Climate Assessment and the Wisconsin Initiative on Climate Change Impacts (WICCI). The course was organized by members of the Department of Atmospheric and Oceanic Sciences and the Cooperative Institute for Meteorological Satellite Studies; material included discussion, videos for lectures as well as guest lecturers. There were also weekly visits by the course team to 21 public libraries throughout the state of WI. The library collaboration as facilitated by WiLS (Wisconsin Library Services - wils.org), who organized the application and selection process. The public libraries hosted local residents and course instructors in discussions of course content in the context of their communities as well as strategies to mitigate the climate change impacts. This presentation will discuss the public library discussions experience and the our evaluation of the impact of including a face-to-face component in the MOOC activity on engagement and learning.

The SOLO Librarian's Sourcebook.

ERIC Educational Resources Information Center

Siess, Judith A.

This book provides an introduction to single staff information services, or SOLO librarianship. SOLO librarians are usually found in corporate libraries, private companies, small public libraries, museums, schools, churches or synagogues, prisons, law firms, hospitals or special libraries with specialized or limited materials and services with…

The Use of EST Expression Matrixes for the Quality Control of Gene Expression Data

PubMed Central

Milnthorpe, Andrew T.; Soloviev, Mikhail

2012-01-01

EST expression profiling provides an attractive tool for studying differential gene expression, but cDNA libraries' origins and EST data quality are not always known or reported. Libraries may originate from pooled or mixed tissues; EST clustering, EST counts, library annotations and analysis algorithms may contain errors. Traditional data analysis methods, including research into tissue-specific gene expression, assume EST counts to be correct and libraries to be correctly annotated, which is not always the case. Therefore, a method capable of assessing the quality of expression data based on that data alone would be invaluable for assessing the quality of EST data and determining their suitability for mRNA expression analysis. Here we report an approach to the selection of a small generic subset of 244 UniGene clusters suitable for identification of the tissue of origin for EST libraries and quality control of the expression data using EST expression information alone. We created a small expression matrix of UniGene IDs using two rounds of selection followed by two rounds of optimisation. Our selection procedures differ from traditional approaches to finding “tissue-specific” genes and our matrix yields consistency high positive correlation values for libraries with confirmed tissues of origin and can be applied for tissue typing and quality control of libraries as small as just a few hundred total ESTs. Furthermore, we can pick up tissue correlations between related tissues e.g. brain and peripheral nervous tissue, heart and muscle tissues and identify tissue origins for a few libraries of uncharacterised tissue identity. It was possible to confirm tissue identity for some libraries which have been derived from cancer tissues or have been normalised. Tissue matching is affected strongly by cancer progression or library normalisation and our approach may potentially be applied for elucidating the stage of normalisation in normalised libraries or for cancer staging. PMID:22412959

Data at Risk and Research Libraries

NASA Astrophysics Data System (ADS)

Choudhury, S.

2017-12-01

Research libraries have recently engaged in data rescue events amidst growing concerns about access to federal data sets. While these efforts are well intentioned, libraries run the risk of ignoring a long established history of activities and accomplishments by other communities focused on data at risk, many of which are represented at forums such as AGU. Under the auspices of the Data Conservancy, the Sheridan Libraries at Johns Hopkins University hosted an event in July 2017 that convened members of various communities including ESIP, RDA, Data Rescue Boulder, Association of Research Libraries, the Fedora repository platform, the Open Science Framework and the Interplanetary File System or IPFS (via the Data Together Network). This group identified a potential role for research libraries to partner with existing players in the data at risk community by focusing on a distributed preservation network as part of a coordinated collection development program. This session will offer an opportunity to hear about this potential role for research libraries and to provide feedback about its viability and utility.

Microcomputers in Libraries.

ERIC Educational Resources Information Center

Ertel, Monica M.

1984-01-01

This discussion of current microcomputer technologies available to libraries focuses on software applications in four major classifications: communications (online database searching); word processing; administration; and database management systems. Specific examples of library applications are given and six references are cited. (EJS)

National Library Service of the Library of Congress: New Electronic Information Projects. Part Four of a Four-Part Series.

ERIC Educational Resources Information Center

McNulty, Tom, Ed.

1995-01-01

This final installment of a four-part series on the National Library Service (NLS) examines recently implemented and future projects, with a focus on alternative formats for patrons with disabilities. Discusses LOCIS, the Library of Congress online public access catalog; MARVEL, the Library of Congress gopher; the NLS Web site; and computer disk…

Usability Testing for e-Resource Discovery: How Students Find and Choose e-Resources Using Library Web Sites

ERIC Educational Resources Information Center

Fry, Amy; Rich, Linda

2011-01-01

In early 2010, library staff at Bowling Green State University (BGSU) in Ohio designed and conducted a usability study of key parts of the library web site, focusing on the web pages generated by the library's electronic resources management system (ERM) that list and describe the library's databases. The goal was to discover how users find and…

A Vision for the Future: Henry G. Bennett Memorial Library, Southeastern Oklahoma State University Strategic Plan, 2002-2007.

ERIC Educational Resources Information Center

Davis, Dorothy

This document presents the five-year strategic plan developed by the library director, staff, and the Library Committee for the Henry G. Bennett Memorial Library, Southeastern Oklahoma State University. The goal of this plan is to provide a framework that the library can use to focus energy and resources in fulfilling the mission of the library…

Medical libraries, bioinformatics, and networked information: a coming convergence?

PubMed

Lynch, C

1999-10-01

Libraries will be changed by technological and social developments that are fueled by information technology, bioinformatics, and networked information. Libraries in highly focused settings such as the health sciences are at a pivotal point in their development as the synthesis of historically diverse and independent information sources transforms health care institutions. Boundaries are breaking down between published literature and research data, between research databases and clinical patient data, and between consumer health information and professional literature. This paper focuses on the dynamics that are occurring with networked information sources and the roles that libraries will need to play in the world of medical informatics in the early twenty-first century.

Library Economic Metrics: Examples of the Comparison of Electronic and Print Journal Collections and Collection Services.

ERIC Educational Resources Information Center

King, Donald W.; Boyce, Peter B.; Montgomery, Carol Hansen; Tenopir, Carol

2003-01-01

Focuses on library economic metrics, and presents a conceptual framework for library economic metrics including service input and output, performance, usage, effectiveness, outcomes, impact, and cost and benefit comparisons. Gives examples of these measures for comparison of library electronic and print collections and collection services.…

Incorporating Library School Interns on Academic Library Subject Teams

ERIC Educational Resources Information Center

Sargent, Aloha R.; Becker, Bernd W.; Klingberg, Susan

2011-01-01

This case study analyzes the use of library school interns on subject-based teams for the social sciences, humanities, and sciences in the San Jose State University Library. Interns worked closely with team librarians on reference, collection development/management, and instruction activities. In a structured focus group, interns reported that the…

The Library in Tomorrow's Society. A Literature Review.

ERIC Educational Resources Information Center

Roberts, Kenneth H.

Intended to reflect the international library community's expectations for the next 10 to 15 years and the place of the library in tomorrow's world, this extensive selective review focuses on the professional literature published between 1982 and 1986 which treats the probable evolution of different types of libraries in both developed and…

External Reporting Lines of Academic Special Libraries: A Health Sciences Case Study

ERIC Educational Resources Information Center

Buhler, Amy G.; Ferree, Nita; Cataldo, Tara T.; Tennant, Michele R.

2010-01-01

Very little literature exists on the nature of external reporting lines and funding structures of academic special libraries. This study focuses on academic health sciences libraries. The authors analyze information gathered from statistics published by the Association of Academic Health Sciences Libraries (AAHSL) from 1977 through 2007; an…

IFLA General Conference, 1990. IFLA Presession Seminar on Public Library Policy.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Five of the six papers in this collection focus on public library services, collection development problems, and involvement in literacy campaigns in developing countries; the sixth paper is concerned with public library services in Norway. (1) In "Big Cities, Its Inhabitants and Public Libraries Systems," May Brooking Negrao examines…

Once upon a Tale. 1995 Florida Library Youth Program.

ERIC Educational Resources Information Center

Abramoff, Carolann Palm, Comp.; And Others

The Florida Library Youth Program is an extension of the Florida Summer Library Program. Many libraries have wanted to provide programs for school-age children at times other than the traditional summer vacation, and this guide responds to their needs. The theme, "Once Upon a Tale," focuses on folklore, stories, and storytelling. The…

Selecting and Acquiring Library Materials for Chinese Studies in Academic Libraries

ERIC Educational Resources Information Center

Wei, Karen T.

2004-01-01

Focusing on academic libraries in North America, this article describes the selection and acquisition of library materials for Chinese Studies from the People's Republic of China, Hong Kong, and Taiwan. It provides an historical overview of the Chinese book publishing and exporting practice, identifies and evaluates current online and printed…

DELIVERing Library Resources to the Virtual Learning Environment

ERIC Educational Resources Information Center

Secker, Jane

2005-01-01

Purpose: Examines a project to integrate digital libraries and virtual learning environments (VLE) focusing on requirements for online reading list systems. Design/methodology/approach: Conducted a user needs analysis using interviews and focus groups and evaluated three reading or resource list management systems. Findings: Provides a technical…

Provision of Computer Printing Capabilities to Library Patrons. SPEC Kit 183.

ERIC Educational Resources Information Center

Taylor, Suzanne; Welch, C. Brigid, Ed.

1992-01-01

This publication reports on the results of a 1992 survey of 80 Association of Research Libraries (ARL) member libraries on their use of printers for recording references found in online public access catalog (OPAC) and CD-ROM searches. As was found in a 1990 survey on the same topic, only a small proportion of libraries reported that they charged…

Library Builder: Kimberly Martin--Bonner Springs City Library, KS

ERIC Educational Resources Information Center

Library Journal, 2004

2004-01-01

Kimberly Martin is just 30, but she's been reinventing the Bonner Springs City Library since late 1998, even before she earned her library degree. Some 20 minutes west of Kansas City, Bonner Springs is a small town (service population around 10,000) in a bustling metropolitan area. Martin's goal is to provide service on a par with the larger…

A novel small molecule, Rosline, inhibits growth and induces caspase-dependent apoptosis in human lung cancer cells A549 through a reactive oxygen species-dependent mechanism.

PubMed

Zhao, Ting; Feng, Yang; Jin, Wenling; Pan, Hui; Li, Haizhou; Zhao, Yang

2016-06-01

Chemical screening using synthetic small molecule libraries has provided a huge amount of novel active molecules. It generates lead compound for drug development and brings focus on molecules for mechanistic investigations on many otherwise intangible biological processes. In this study, using non-small cell lung cancer cell A549 to screen against a structurally novel and diverse synthetic small molecule library of 2,400 compounds, we identified a molecule named rosline that has strong anti-proliferation activity on A549 cells with a 50% cell growth inhibitory concentration (IC50 ) of 2.87 ± 0.39 µM. We showed that rosline treatment increased the number of Annexin V-positive staining cell, as well as G2/M arrest in their cell cycle progression. Further, we have demonstrated that rosline induces a decrease of mitochondrial membrane potential (Δφm ) and an increase of caspases 3/7 and 9 activities in A549 cells, although having no effect on the activity of caspase 8. Moreover, we found that rosline could induce the production of reactive oxygen species (ROS) and inhibit the phosphorylation of signaling molecule Akt in A549 cells. Alternatively, an antioxidant N-acetyl-L-cysteine (NAC) significantly attenuated rosline's effects on the mitochondrial membrane potential, caspases 3/7 and 9 activities, cell viabilities and the phosphorylation of Akt. Our results demonstrated that ROS played an important role in the apoptosis of A549 cells induced by rosline. © 2016 International Federation for Cell Biology.

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

PubMed Central

Bray, Mark-Anthony; Gustafsdottir, Sigrun M; Rohban, Mohammad H; Singh, Shantanu; Ljosa, Vebjorn; Sokolnicki, Katherine L; Bittker, Joshua A; Bodycombe, Nicole E; Dančík, Vlado; Hasaka, Thomas P; Hon, Cindy S; Kemp, Melissa M; Li, Kejie; Walpita, Deepika; Wawer, Mathias J; Golub, Todd R; Schreiber, Stuart L; Clemons, Paul A; Shamji, Alykhan F

2017-01-01

Abstract Background Large-scale image sets acquired by automated microscopy of perturbed samples enable a detailed comparison of cell states induced by each perturbation, such as a small molecule from a diverse library. Highly multiplexed measurements of cellular morphology can be extracted from each image and subsequently mined for a number of applications. Findings This microscopy dataset includes 919 265 five-channel fields of view, representing 30 616 tested compounds, available at “The Cell Image Library” (CIL) repository. It also includes data files containing morphological features derived from each cell in each image, both at the single-cell level and population-averaged (i.e., per-well) level; the image analysis workflows that generated the morphological features are also provided. Quality-control metrics are provided as metadata, indicating fields of view that are out-of-focus or containing highly fluorescent material or debris. Lastly, chemical annotations are supplied for the compound treatments applied. Conclusions Because computational algorithms and methods for handling single-cell morphological measurements are not yet routine, the dataset serves as a useful resource for the wider scientific community applying morphological (image-based) profiling. The dataset can be mined for many purposes, including small-molecule library enrichment and chemical mechanism-of-action studies, such as target identification. Integration with genetically perturbed datasets could enable identification of small-molecule mimetics of particular disease- or gene-related phenotypes that could be useful as probes or potential starting points for development of future therapeutics. PMID:28327978

Three CEOs, Three Futures.

ERIC Educational Resources Information Center

Berry, John N., III

1998-01-01

Interviews with three CEOs--UMI (University Microfilms International), OCLC (Online Computer Library Center), and Gale Research--focus on outlooks for information and libraries. Discusses expanded educational Web services/courseware, library role in delivery, electronic dissertation publishing, digital data conversion, thesauri/indexing, union…

Selected reference aids for small medical libraries.

PubMed

Duncan, H F

1970-04-01

This annotated list of 178 items is compiled as a guide to the development of the reference collection in a small medical library.Arrangement, following the pattern of the previous revision, is by broad subject groups. Titles are chiefly in English. Textbooks in subject fields have been omitted since these are covered adequately in several comprehensive guides to the literature.

Selected List of Books and Journals for the Small Medical Library *

PubMed Central

Brandon, Alfred N.

1967-01-01

This updated list of 388 books and 140 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. PMID:6041826

Focusing the One-Shot Lecture.

ERIC Educational Resources Information Center

Allen, Mary Beth

1989-01-01

Describes a library instruction program at the University of Illinois that consists of a narrowly focused one-shot lecture, complemented by a series of library activities that can be completed independently by students. The reasons for revising the program, the variety of instructional approaches and media used, and the effectiveness of the…

Diagnostic utility of alpha-methylacyl CoA racemase (P504S) on prostate needle biopsy.

PubMed

Jiang, Zhong; Woda, Bruce A

2004-11-01

Alpha-methylacyl CoA racemase (AMACR), also known as P504S, was identified by the analysis of cDNA library subtraction in conjunction with high throughput microarray screening from prostate tissue and has been proven to be one of the very few biomarkers that can distinguish cancer from benign cells with high sensitivity and specificity for prostate carcinoma. It is a successful example of the translation of molecular findings into clinical practice. This review focuses on the study of AMACR (P504S) expression in small focal prostate cancer and atypical small acinar proliferation (ASAP) on needle biopsies and emphasizes the utility of AMACR (P504S) in routine surgical pathology practice. We also discuss the potential pitfalls and caveats in the interpretation of immunostaining results.

"I Wish Everyone Had a Library Like This": Year 2 Report on the Baltimore Elementary and Middle School Library Project

ERIC Educational Resources Information Center

Sheldon, Steven B.; Davis, Marcia H.

2015-01-01

This report focuses on the opening of new school libraries and their impact on schools, teachers and students after two years of implementation of the Baltimore Elementary and Middle School Library Project (Library Project). The findings build on the first report of this project and show that it is not just new facilities, but also the added…

Structure-Based Virtual Screening of Commercially Available Compound Libraries.

PubMed

Kireev, Dmitri

2016-01-01

Virtual screening (VS) is an efficient hit-finding tool. Its distinctive strength is that it allows one to screen compound libraries that are not available in the lab. Moreover, structure-based (SB) VS also enables an understanding of how the hit compounds bind the protein target, thus laying ground work for the rational hit-to-lead progression. SBVS requires a very limited experimental effort and is particularly well suited for academic labs and small biotech companies that, unlike pharmaceutical companies, do not have physical access to quality small-molecule libraries. Here, we describe SBVS of commercial compound libraries for Mer kinase inhibitors. The screening protocol relies on the docking algorithm Glide complemented by a post-docking filter based on structural protein-ligand interaction fingerprints (SPLIF).

An Integrated Library System: Preliminary Considerations.

ERIC Educational Resources Information Center

Neroda, Edward

Noting difficulties experienced by small to medium sized colleges in acquiring integrated library computer systems, this position paper outlines issues related to the subject with the intention of increasing familiarity and interest in integrated library systems. The report includes: a brief review of technological advances as they relate to…

The Four-Year Liberal Arts College Library: A Descriptive Profile.

ERIC Educational Resources Information Center

Buttlar, Lois; Garcha, Rajinder

1995-01-01

Presents a study of staffing, services, budgets, collections, and facilities of small academic libraries and offers a statistical and demographic profile of a four-year liberal arts college library. Results are presented in tables, and an appendix lists coding sheets used for the study. (JMV)

Evolution of Scientific and Technical Information Distribution

NASA Technical Reports Server (NTRS)

Esler, Sandra; Nelson, Michael L.

1998-01-01

World Wide Web (WWW) and related information technologies are transforming the distribution of scientific and technical information (STI). We examine 11 recent, functioning digital libraries focusing on the distribution of STI publications, including journal articles, conference papers, and technical reports. We introduce 4 main categories of digital library projects: based on the architecture (distributed vs. centralized) and the contributor (traditional publisher vs. authoring individual/organization). Many digital library prototypes merely automate existing publishing practices or focus solely on the digitization of the publishing cycle output, not sampling and capturing elements of the input. Still others do not consider for distribution the large body of "gray literature." We address these deficiencies in the current model of STI exchange by suggesting methods for expanding the scope and target of digital libraries by focusing on a greater source of technical publications and using "buckets," an object-oriented construct for grouping logically related information objects, to include holdings other than technical publications.

Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations.

PubMed

Tran, Tuan; Disney, Matthew D

2012-01-01

RNA is an important therapeutic target but information about RNA-ligand interactions is limited. Here, we report a screening method that probes over 3,000,000 combinations of RNA motif-small molecule interactions to identify the privileged RNA structures and chemical spaces that interact. Specifically, a small molecule library biased for binding RNA was probed for binding to over 70,000 unique RNA motifs in a high throughput solution-based screen. The RNA motifs that specifically bind each small molecule were identified by microarray-based selection. In this library-versus-library or multidimensional combinatorial screening approach, hairpin loops (among a variety of RNA motifs) were the preferred RNA motif space that binds small molecules. Furthermore, it was shown that indole, 2-phenyl indole, 2-phenyl benzimidazole and pyridinium chemotypes allow for specific recognition of RNA motifs. As targeting RNA with small molecules is an extremely challenging area, these studies provide new information on RNA-ligand interactions that has many potential uses.

Identifying the Preferred RNA Motifs and Chemotypes that Interact by Probing Millions of Combinations

PubMed Central

Tran, Tuan; Disney, Matthew D.

2012-01-01

RNA is an important therapeutic target but information about RNA-ligand interactions is limited. Here we report a screening method that probes over 3,000,000 combinations of RNA motif-small molecule interactions to identify the privileged RNA structures and chemical spaces that interact. Specifically, a small molecule library biased for binding RNA was probed for binding to over 70,000 unique RNA motifs in a high throughput solution-based screen. The RNA motifs that specifically bind each small molecule were identified by microarray-based selection. In this library-versus-library or multidimensional combinatorial screening approach, hairpin loops (amongst a variety of RNA motifs) were the preferred RNA motif space that binds small molecules. Furthermore, it was shown that indole, 2-phenyl indole, 2-phenyl benzimidazole, and pyridinium chemotypes allow for specific recognition of RNA motifs. Since targeting RNA with small molecules is an extremely challenging area, these studies provide new information on RNA-ligand interactions that has many potential uses. PMID:23047683

Alabama Public Library Service, 1987 Annual Report.

ERIC Educational Resources Information Center

Alabama Public Library Service, Montgomery.

Designed to provide an overview of the range and quality of services provided by the Alabama Public Library Service (APLS), this annual report focuses on the 1987 activities of APLS. A report on the activities of the Library Development Division shows the allocation of state aid and Library Services and Construction Act (LCSA) Titles I and III…

Power to the People: End-User Building of Digital Library Collections.

ERIC Educational Resources Information Center

Witten, Ian H.; Bainbridge, David; Boddie, Stefan J.

Digital library systems focus principally on the reader: the consumer of the material that constitutes the library. In contrast, this paper describes an interface that makes it easy for people to build their own library collections. Collections may be built and served locally from the user's own Web server, or (given appropriate permissions)…

Faculty and Student Assessment of the Citadel Library User Services.

ERIC Educational Resources Information Center

Maynard, J. Edmund

The focus of this study was a survey of faculty and student use/needs of library services and user education at Daniel Library, the Citadel, the Military College of South Carolina. More specifically, the study sought to determine user information needs and how the library staff should adapt for meeting the educational and research needs of its…

Technical Writing: Library Resources for Engineers. A Self-Paced Workbook for the University of Arkansas Libraries. Revised.

ERIC Educational Resources Information Center

Dew, Stephen H.

This self-paced library workbook is a course requirement of all "technical writing" freshman English classes at the University of Arkansas. The technical writing course is required of all engineering students, and its major focus is on writing a term paper containing a bibliography produced through library research. The workbook…

Public Libraries Going Green

ERIC Educational Resources Information Center

Miller, Kathryn

2010-01-01

Going green is now a national issue, and patrons expect their library to respond in the same way many corporations have. Libraries are going green with logos on their Web sites, programs for the public, and a host of other initiatives. This is the first book to focus strictly on the library's role in going green, helping you with: (1) Collection…

First-Generation Undergraduate Library Users: Experiences and Perceptions of the Library as Place

ERIC Educational Resources Information Center

Neurohr, Karen A.

2017-01-01

Research focused on first-generation college students has developed considerably in recent years, yet an area that remains relatively unexplored is students' perceptions of the academic library as place. Exploring such perceptions is important for deepening understanding of how the library, as a central academic resource on campus, can best serve…

How Accessible Are Public Libraries' Web Sites? A Study of Georgia Public Libraries

ERIC Educational Resources Information Center

Ingle, Emma; Green, Ravonne A.; Huprich, Julia

2009-01-01

One issue that public librarians must consider when planning Web site design is accessibility for patrons with disabilities. This article reports a study of Web site accessibility of public libraries in Georgia. The focus of the report is whether public libraries use accessible guidelines and standards in making their Web sites accessible. An…

Focus on Academic and Research Libraries: Librarians Speak Out to Journal Publishers

ERIC Educational Resources Information Center

Kaser, Dick

2009-01-01

What is the economic situation in libraries these days? What are academic and research libraries doing with regard to making the resources in their collections more discoverable? Are they involved in institutional repository (IR) projects? And how do IRs and the availability of open access journals affect library purchasing decisions? Those were…

America's Youth Are at Risk: Developing Models for Action in the Nation's Public Libraries.

ERIC Educational Resources Information Center

Flum, Judith G.; Weisner, Stan

1993-01-01

Discussion of public library support systems for at-risk teens focuses on the Bay Area Library and Information System (BALIS) that was developed to improve library services to at-risk teenagers in the San Francisco Bay area. Highlights include needs assessment; staff training; intervention models; and project evaluation. (10 references) (LRW)

How School Librarians Help Kids Achieve Standards: The Second Colorado Study.

ERIC Educational Resources Information Center

Lance, Keith Curry; Rodney, Marcia J.; Hamilton-Pennell, Christine

In 1993, the Colorado State Library published "The Impact of School Library Media Centers on Academic Achievement." This follow-up study focuses attention on the library media specialist and the services she or he provides throughout the building, rather than just the library media center as a specific place, and emphasizes the fact that…

Joint-Use Libraries: More Bang for Your Bucks.

ERIC Educational Resources Information Center

Kinsey, Sally; Honig-Bear, Sharon

1994-01-01

Discussion of joint-use, or cooperative, libraries focuses on a partnership between public and school libraries in Nevada. Highlights include benefits in enhanced services, user needs, location of facilities, administration and planning, financial issues, facility maintenance, remodelling, and signage. (LRW)

Cataloging Before and After OCLC. Illinois Valley Library System OCLC Experimental Project. Report No. 3.

ERIC Educational Resources Information Center

Bills, Linda G.

A project was conducted from 1980 to 1982 to determine the costs and benefits of OCLC use in 29 small and medium-sized member libraries of the Illinois Valley Library System (IVLS). Academic, school, public, and special libraries participated by recording the time and staffing levels used for and the cost of OCLC and pre-OCLC cataloging (by…

Selected list of books and journals for the small medical library.

PubMed Central

Brandon, A N; Hill, D R

1997-01-01

The introduction to this revised list (seventeenth version) of 610 books and 141 journals addresses the origin, three decades ago, of the "Selected List of Books and Journals for the Small Medical Library," and the accomplishments of the late Alfred N. Brandon in helping health sciences librarians, and especially hospital librarians, to envision what collection development and a library collection are all about. This list is intended as a selection guide for the small or medium-size library in a hospital or similar facility. More realistically, it can function as a core collection for a library consortium. Books and journals are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals by an alphabetical title listing. Due to continuing requests from librarians, a "minimal core" book collection consisting of 78 titles has been pulled out from the 200 asterisked (*) initial-purchase books and marked with daggers ([symbol: see text]). To purchase the entire collection of books and to pay for 1997 journal subscriptions would require $101,700. The cost of only the asterisked items, books and journals, totals $43,100. The "minimal core" book collection costs $12,600. PMID:9160148

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N; Hill, D R

1997-04-01

The introduction to this revised list (seventeenth version) of 610 books and 141 journals addresses the origin, three decades ago, of the "Selected List of Books and Journals for the Small Medical Library," and the accomplishments of the late Alfred N. Brandon in helping health sciences librarians, and especially hospital librarians, to envision what collection development and a library collection are all about. This list is intended as a selection guide for the small or medium-size library in a hospital or similar facility. More realistically, it can function as a core collection for a library consortium. Books and journals are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals by an alphabetical title listing. Due to continuing requests from librarians, a "minimal core" book collection consisting of 78 titles has been pulled out from the 200 asterisked (*) initial-purchase books and marked with daggers ([symbol: see text]). To purchase the entire collection of books and to pay for 1997 journal subscriptions would require $101,700. The cost of only the asterisked items, books and journals, totals $43,100. The "minimal core" book collection costs $12,600.

OCLC--A Personal Network.

ERIC Educational Resources Information Center

Thompson, Dorothea M.

1985-01-01

Tabulation of an academic library's record of improved success rate and fill time for interlibrary loans utilizing the OCLC interlibrary loan subsystem supports continued use of four common-sense rules: use OCLC first; use other union lists next; select smallest nearby library; spread requests among small libraries. Twelve references are cited.…

Manual for Librarians in Small Hospitals. Sixth Edition.

ERIC Educational Resources Information Center

Graham, Elaine, Ed.; Kesti, Julie, Ed.

This manual is designed to aid the inexperienced person assigned to a hospital library and given the responsibility of ordering library materials, organizing the collection, borrowing from other libraries, and seeking information. Following a brief introduction, the manual is divided into 10 chapters: (1) Organization and Administration of the…

Campus Partner Collections: Expanding the Boundaries of the Library

ERIC Educational Resources Information Center

Elguindi, Anne C.; Kelshian, Robert; Sandler, Alayne Mundt

2011-01-01

At most colleges and universities, there are a number of small, nonlibrary collections across campus, such as those found in student centers or academic departments. Historically, at American University, partnership with these collections was done through absorbing them into the main library collection. Recently, however, the Library has seen…

Implementing a Systematic Planning Process in Two Very Small Rural Public Libraries.

ERIC Educational Resources Information Center

Senkevitch, Judith J.

1985-01-01

Describes a pilot project by a regional library system in central New York State to implement systematic planning activities in rural public libraries serving populations under 5,000. Motivations for the adoption of innovation and key elements in the decision making process during implementation are examined. (CLB)

Reference and Bibliographic Instruction: A Survey of Philosophy Statements in LIBRAS Libraries.

ERIC Educational Resources Information Center

Keith, Ellen; Kohut, Dave

1998-01-01

A survey of statements of philosophy on reference and bibliographic instruction from libraries in small, Chicago area liberal arts colleges and universities revealed a wide variety of relationships between the two services. The study concluded that most of the libraries surveyed compartmentalized reference and bibliographic instruction. (PEN)

Perceptions of Library Leadership in a Time of Change.

ERIC Educational Resources Information Center

Deekle, Peter V.; de Klerk, Ann

1992-01-01

Reports on a survey of chief academic officers and library directors at over 250 small- and medium-sized private colleges and universities. Responses indicate that institution administrators were aware of new trends in information management but did not recognize library directors' qualifications for broader administrative participation. (11…

A Copyright Primer for Small Undergraduate Libraries

ERIC Educational Resources Information Center

Cottrell, Terry

2010-01-01

Campus librarians play a central role in conversations revolving around copyright compliance. The sheer volume of information provided within library physical and virtual spaces affirms the role libraries play in current copyright debates. Regardless of the function of librarians on any particular campus, it is important to confront the myriad of…

Personal Computing and Academic Library Design.

ERIC Educational Resources Information Center

Bazillion, Richard J.

1992-01-01

Notebook computers of increasing power and portability offer unique advantages to library users. Connecting easily to a campus data network, they are small silent work stations capable of drawing information from a variety of sources. Designers of new library buildings may assume that users in growing numbers will carry these multipurpose…

Welcome to the National Wetlands Research Center Library: Not Just Another Library-A Special Library

USGS Publications Warehouse

Broussard, Linda

2007-01-01

Libraries are grouped into four major types: public, school, academic, and special. The U.S. Geological Survey's (USGS) National Wetlands Research Center (NWRC) library is classified as a special library because it is sponsored by the Federal government, and the collections focus on a specific subject. The NWRC library is the only USGS library dedicated to wetland science. Library personnel offer expert research services to meet the informational needs of NWRC scientists, managers, and support personnel. The NWRC library participates in international cataloging and resource sharing, which allows libraries from throughout the world to borrow from its collections. This sharing facilitates the research of other governmental agencies, universities, and those interested in the study of wetlands.

Design and Synthesis of Biaryl DNA-Encoded Libraries.

PubMed

Ding, Yun; Franklin, G Joseph; DeLorey, Jennifer L; Centrella, Paolo A; Mataruse, Sibongile; Clark, Matthew A; Skinner, Steven R; Belyanskaya, Svetlana

2016-10-10

DNA-encoded library technology (ELT) is a powerful tool for the discovery of new small-molecule ligands to various protein targets. Here we report the design and synthesis of biaryl DNA-encoded libraries based on the scaffold of 5-formyl 3-iodobenzoic acid. Three reactions on DNA template, acylation, Suzuki-Miyaura coupling and reductive amination, were applied in the library synthesis. The three cycle library of 3.5 million diversity has delivered potent hits for phosphoinositide 3-kinase α (PI3Kα).

The Carnegie Mellon/Sirsi Corporation Alliance.

ERIC Educational Resources Information Center

Troll, Denise A.; Depellegrin, Tracey A.; Myers, Melanie D.

1999-01-01

Describes the relationship between Carnegie Mellon University libraries and Sirsi Corporation, their integrated library-management system vendor. Topics include Carnegie Mellon's expertise in library automation research and development; and three primary elements of the alliance: research, including user protocols, surveys, and focus groups;…

How To Host a Library Technology Fair.

ERIC Educational Resources Information Center

Gaudin, Charles

2000-01-01

Describes how the Northwestern State University library organized a successful technology fair that focused on the library and campus technology. Discusses reasons for organizing the fair, including the introduction of new workstations; academic department participation; vendor participation; marketing strategies and communication; and student…

Capital Provision for University Libraries in the United Kingdom--Comments on the Atkinson Report

ERIC Educational Resources Information Center

Taylor, Colin R.

1977-01-01

United Kingdom norms for libraries are reviewed and the effect they would have on Australian university libraries is examined. Focus is on book storage, future growth provision, reader places, administration, reserve storage, and special collections. (LBH)

The Australian Bibliographic Network--An Introduction.

ERIC Educational Resources Information Center

Hannan, Chris

1982-01-01

Focuses on the centralized, online, shared-cataloging facility of the Australian Bibliographic Network operated by the National Library of Australia. Existing automated library systems in Australia, selection and implementation of Washington Library Network software, comparison of Australian and U.S. automation, and projections for future…

Sustainable Library Development Training Package

ERIC Educational Resources Information Center

Peace Corps, 2012

2012-01-01

This Sustainable Library Development Training Package supports Peace Corps' Focus In/Train Up strategy, which was implemented following the 2010 Comprehensive Agency Assessment. Sustainable Library Development is a technical training package in Peace Corps programming within the Education sector. The training package addresses the Volunteer…

Authorship in "College & Research Libraries" Revisited: Gender, Institutional Affiliation, Collaboration.

ERIC Educational Resources Information Center

Terry, James L.

1996-01-01

Updates earlier studies on the characteristics of authorship of articles published in "College & Research Libraries", focusing on gender, institutional affiliation, and extent of collaboration. Results show representation by academic librarians and authors affiliated with library schools increased, collaboration predominated, and…

Librarians as Money Makers: The Bottom Line.

ERIC Educational Resources Information Center

Warner, Alice Sizer

1990-01-01

Discusses the monetary aspects of librarianship, focusing on nontraditional library careers such as intrapreneurship (managing a library within an organization as a business) and entrepreneurship. Fee-based library services are considered, and suggestions for becoming a successful information entrepreneur are offered. (10 references) (MES)

A Feminist Paradigm for Library and Information Science.

ERIC Educational Resources Information Center

Hannigan, Jane Anne; Crew, Hilary

1993-01-01

Discussion of feminist scholarship and feminist thinking focuses on feminism in librarianship. Topics addressed include research methodologies; implications for library and information science; a feminist model, including constructed knowledge; standpoint theory; benefits of feminist scholarship; and a library model. (Contains 14 references.) (LRW)

Liaison Efforts at a Small Business College

ERIC Educational Resources Information Center

Hales, Karen; Ward, Randall; Brown, Annalaura

2009-01-01

At our small business college, we believe that next to serving the students, the most important thing we as librarians can do is serve as liaisons to the faculty. If the faculty is tuned in to the library, it is more likely he or she will use library resources and will teach students about them. This will provide a more effective education for the…

The Publishing of Library and Information Science Journals in Southeast Asia--An Overview.

ERIC Educational Resources Information Center

Yeow-fei, Jaffe Yee

This paper presents an overview of the present state of the publishing activities of library and information science journals in Southeast Asia, focusing on format, circulation/readership, quality, and editorial focus. It also highlights some of the important titles from Thailand, Malaysia, Singapore, the Philippines, Indonesia, Brunei, Vietnam,…

Understand, Identify, and Respond: The New Focus of Access Services

ERIC Educational Resources Information Center

Rodriguez, Juan Carlos; Meyer, Kristin; Merry, Brian

2017-01-01

Library public services staff have primarily focused on providing services through interactions with their users. Although service quality and customer satisfaction are important in the delivery of these services, the emphasis and nature of the work have often been influenced by a library-centric philosophy rather than a user-centric philosophy.…

Libraries and Media around the World. Ohio Media Spectrum. Volume 39, No. 4.

ERIC Educational Resources Information Center

Ohio Media Spectrum, 1987

1987-01-01

Devoted to articles on libraries in foreign countries, this issue of a quarterly journal focuses on how these libraries are using print and nonprint resources to serve their patrons. The structure and organization of these foreign library/media services are discussed, as well as their histories and the constraints that have shaped their services.…

Developing Sustainable Leadership Capability in the Victorian State and Public Library Sector

ERIC Educational Resources Information Center

McCarten, Melanie

2011-01-01

There have been substantial changes in the labour market over the past few years and survey results indicate 60% of staff will leave public library service over the next decade. While this creates opportunities for library staff, limited training budgets and a focus on compliance and specific library skills training have led to a gap in the formal…

Fast Facts: Recent Statistics from the Library Research Service, No. 225-231 (July-November, 2005)

ERIC Educational Resources Information Center

Lietzau, Zeth; Lance, Keith Curry; Dickenson, Don

2005-01-01

Seven issues of Fast Facts from the Library Research Service that cover information from libraries across Colorado are contained in this document. These issues focus on topics from various library sectors and include patron use of AskColorado (a statewide virtual reference service) and the rising use of online services, Colorado public library…

Evaluation of Library Utilization by Students Enrolled in External Degree Programme in University of Nairobi, Kenya

ERIC Educational Resources Information Center

Gor, Peter Ochieng

2012-01-01

With the increasing popularity of distance education, focus has turned to the role of libraries in distance learning process. It is widely agreed that like their campus-based counterparts, distance education learners need adequate library services if they are to gain quality education. This study sought to examine library utilization by students…

At Issue: Exploring Library Usage by Online Learners with Student Success

ERIC Educational Resources Information Center

McCarthy, Sandra Calemme

2017-01-01

The purpose of this study is to extend what is known about the influence of library usage on student success. Studies show that students who use library resources tend to perform better in college. This study focuses on the relationship between library usage and success rates among online students. The results of this study showed that online…

A Catalyst for Change: LSTA Grants to States Program Activities and the Transformation of Library Services to the Public

ERIC Educational Resources Information Center

Institute of Museum and Library Services, 2009

2009-01-01

This report focuses on funding and services provided through the Institute of Museum and Library Services (IMLS) Grants to States program in the most recent full reporting years. IMLS grants to State Library Administrative Agencies (SLAA's) represent the single largest source of federal funding for the nation's libraries and are the only…

Brick and Click Libraries: Proceedings of an Academic Library Symposium (Maryville, Missouri, October 22, 2004)

ERIC Educational Resources Information Center

Baudino, Frank, Ed.; Mardis, Lori, Ed.; Park, Sarah G., Ed.; Ury, Connie J., Ed.

2004-01-01

The Brick & Click Libraries Symposium is a one-day conference that focuses on providing library resources and services for students who are either on-campus learners or off-campus learners. It is sponsored by Northwest Missouri State University in order to offer academic librarians a forum for sharing practical information. The subjects and…

Risk Management and Disaster Recovery in Public Libraries in South Australia: A Pilot Study

ERIC Educational Resources Information Center

Velasquez, Diane L.; Evans, Nina; Kaeding, Joanne

2016-01-01

Introduction: This paper reports the findings of a study of risk management in public libraries. The focus of the research was to determine whether the libraries had a risk management and disaster plan for major disasters. Method: A qualitative study was done to investigate risk management and disaster recovery in public libraries in South…

Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds

PubMed Central

Virshup, Aaron M.; Contreras-García, Julia; Wipf, Peter; Yang, Weitao; Beratan, David N.

2013-01-01

The “small molecule universe” (SMU), the set of all synthetically feasible organic molecules of 500 Daltons molecular weight or less, is estimated to contain over 1060 structures, making exhaustive searches for structures of interest impractical. Here, we describe the construction of a “representative universal library” spanning the SMU that samples the full extent of feasible small molecule chemistries. This library was generated using the newly developed Algorithm for Chemical Space Exploration with Stochastic Search (ACSESS). ACSESS makes two important contributions to chemical space exploration: it allows the systematic search of the unexplored regions of the small molecule universe, and it facilitates the mining of chemical libraries that do not yet exist, providing a near-infinite source of diverse novel compounds. PMID:23548177

Design of diversity and focused combinatorial libraries in drug discovery.

PubMed

Young, S Stanley; Ge, Nanxiang

2004-05-01

Using well-characterized chemical reactions and readily available monomers, chemists are able to create sets of compounds, termed libraries, which are useful in drug discovery processes. The design of combinatorial chemical libraries can be complex and there has been much information recently published offering suggestions on how the design process can be carried out. This review focuses on literature with the goal of organizing current thinking. At this point in time, it is clear that benchmarking of current suggested methods is required as opposed to further new methods.

Nuclear data libraries assessment for modelling a small fluoride salt-cooled, high-temperature reactor

NASA Astrophysics Data System (ADS)

Mohamed, Hassan; Lindley, Benjamin; Parks, Geoffrey

2017-01-01

Nuclear data consists of measured or evaluated probabilities of various fundamental physical interactions involving the nuclei of atoms and their properties. Most fluoride salt-cooled high-temperature reactor (FHR) studies that were reviewed do not give detailed information on the data libraries used in their assessments. Therefore, the main objective of this data libraries comparison study is to investigate whether there are any significant discrepancies between main data libraries, namely ENDF/B-VII, JEFF-3.1 and JEF-2.2. Knowing the discrepancies, especially its magnitude, is important and relevant for readers as to whether further cautions are necessary for any future verification or validation processes when modelling an FHR. The study is performed using AMEC's reactor physics software tool, WIMS. The WIMS calculation is simply a 2-D infinite lattice of fuel assembly calculation. The comparison between the data libraries in terms of infinite multiplication factor, kinf and pin power map are presented. Results show that the discrepancy between JEFF-3.1 and ENDF/B-VII libraries is reasonably small but increases as the fuel depletes due to the data libraries uncertainties that are accumulated at each burnup step. Additionally, there are large discrepancies between JEF-2.2 and ENDF/B-VII because of the inadequacy of the JEF-2.2 library.

Using scientific evidence to improve hospital library services: Southern Chapter/Medical Library Association journal usage study.

PubMed

Dee, C R; Rankin, J A; Burns, C A

1998-07-01

Journal usage studies, which are useful for budget management and for evaluating collection performance relative to library use, have generally described a single library or subject discipline. The Southern Chapter/Medical Library Association (SC/MLA) study has examined journal usage at the aggregate data level with the long-term goal of developing hospital library benchmarks for journal use. Thirty-six SC/MLA hospital libraries, categorized for the study by size as small, medium, or large, reported current journal title use centrally for a one-year period following standardized data collection procedures. Institutional and aggregate data were analyzed for the average annual frequency of use, average costs per use and non-use, and average percent of non-used titles. Permutation F-type tests were used to measure difference among the three hospital groups. Averages were reported for each data set analysis. Statistical tests indicated no significant differences between the hospital groups, suggesting that benchmarks can be derived applying to all types of hospital libraries. The unanticipated lack of commonality among heavily used titles pointed to a need for uniquely tailored collections. Although the small sample size precluded definitive results, the study's findings constituted a baseline of data that can be compared against future studies.

Using scientific evidence to improve hospital library services: Southern Chapter/Medical Library Association journal usage study.

PubMed Central

Dee, C R; Rankin, J A; Burns, C A

1998-01-01

BACKGROUND: Journal usage studies, which are useful for budget management and for evaluating collection performance relative to library use, have generally described a single library or subject discipline. The Southern Chapter/Medical Library Association (SC/MLA) study has examined journal usage at the aggregate data level with the long-term goal of developing hospital library benchmarks for journal use. METHODS: Thirty-six SC/MLA hospital libraries, categorized for the study by size as small, medium, or large, reported current journal title use centrally for a one-year period following standardized data collection procedures. Institutional and aggregate data were analyzed for the average annual frequency of use, average costs per use and non-use, and average percent of non-used titles. Permutation F-type tests were used to measure difference among the three hospital groups. RESULTS: Averages were reported for each data set analysis. Statistical tests indicated no significant differences between the hospital groups, suggesting that benchmarks can be derived applying to all types of hospital libraries. The unanticipated lack of commonality among heavily used titles pointed to a need for uniquely tailored collections. CONCLUSION: Although the small sample size precluded definitive results, the study's findings constituted a baseline of data that can be compared against future studies. PMID:9681164

A Model Assessing Relevant Factors in Building Minority Library Service.

ERIC Educational Resources Information Center

Bonin, Kenneth Roy

1983-01-01

Presents research design applicable to definition of minority library service needs for any minority language group in Canada, focusing on French-speaking population outside Quebec. Profiles of the target group's population, culture, needs, and library services are highlighted. Five sources are given. (EJS)

Educational Technology Funding Models

ERIC Educational Resources Information Center

Mark, Amy E.

2008-01-01

Library and cross-disciplinary literature all stress the increasing importance of instructional technology in higher education. However, there is a dearth of articles detailing funding for library instructional technology. The bulk of library literature on funding for these projects focuses on one-time grant opportunities and on the architecture…

"Library Quarterly" Management Literature, 1931-2004

ERIC Educational Resources Information Center

Young, Arthur P.

2006-01-01

Management literature appearing in "Library Quarterly," 1931-2004, is examined in this essay. A total of 145 articles are identified that focus on administrative and managerial issues related to libraries during this period. Management literature is construed expansively and includes accounting, administration, assessment, budgets, facilities,…

A mapping review of the literature on UK-focused health and social care databases.

PubMed

Cooper, Chris; Rogers, Morwenna; Bethel, Alison; Briscoe, Simon; Lowe, Jenny

2015-03-01

Bibliographic databases are a day-to-day tool of the researcher: they offer the researcher easy and organised access to knowledge, but how much is actually known about the databases on offer? The focus of this paper is UK health and social care databases. These databases are often small, specialised by topic, and provide a complementary literature to the large, international databases. There is, however, good evidence that these databases are overlooked in systematic reviews, perhaps because little is known about what they can offer. To systematically locate and map, published and unpublished literature on the key UK health and social care bibliographic databases. Systematic searching and mapping. Two hundred and forty-two items were identified which specifically related to the 24 of the 34 databases under review. There is little published or unpublished literature specifically analysing the key UK health and social care databases. Since several UK databases have closed, others are at risk, and some are overlooked in reviews, better information is required to enhance our knowledge. Further research on UK health and social care databases is required. This paper suggests the need to develop the evidence base through a series of case studies on each of the databases. © 2014 The authors. Health Information and Libraries Journal © 2014 Health Libraries Journal.

In-House Automation of a Small Library Using a Mainframe Computer.

ERIC Educational Resources Information Center

Waranius, Frances B.; Tellier, Stephen H.

1986-01-01

An automated library routine management system was developed in-house to create system unique to the Library and Information Center, Lunar and Planetary Institute, Houston, Texas. A modular approach was used to allow continuity in operations and services as system was implemented. Acronyms and computer accounts and file names are appended.…

Model Preservation Program for a Small University Library.

ERIC Educational Resources Information Center

Robbins, Louise S.

This report proposes a preservation program assuming a model of a university library serving 5,000 or fewer students and 350 or fewer faculty members. The model program is not for a comprehensive university or research institution, and the library's collection is one developed and used as a curriculum-support collection. The goal of the…

E-Books in Academic Libraries: Results of a Survey Carried out in Sweden and Lithuania

ERIC Educational Resources Information Center

Maceviciute, Elena; Wilson, T. D.; Gudinavicius, Arunas; Šuminas, Andrius

2017-01-01

Introduction: This paper reports on a study of e-books issues in academic libraries in two European countries representative of small language markets--Sweden and Lithuania. Method: Questionnaire surveys, using the same instrument, were carried out in Swedish and Lithuanian academic libraries. Analysis: Quantitative analysis was performed using…

Interlibrary Loan Trends: Staffing and Organization. SPEC Kit #187.

ERIC Educational Resources Information Center

Dearie, Tammie Nickelson, Comp.; Steel, Virginia, Comp.

Topics related to research library interlibrary loan staffing and organizational structures were explored through a survey conducted by the Systems and Procedures Exchange Center (SPEC) of the Association of Research Libraries. Data gathered from 82 libraries show a very small increase in the number of full-time equivalents in loan units between…

Generating Focused Molecule Libraries for Drug Discovery with Recurrent Neural Networks

PubMed Central

2017-01-01

In de novo drug design, computational strategies are used to generate novel molecules with good affinity to the desired biological target. In this work, we show that recurrent neural networks can be trained as generative models for molecular structures, similar to statistical language models in natural language processing. We demonstrate that the properties of the generated molecules correlate very well with the properties of the molecules used to train the model. In order to enrich libraries with molecules active toward a given biological target, we propose to fine-tune the model with small sets of molecules, which are known to be active against that target. Against Staphylococcus aureus, the model reproduced 14% of 6051 hold-out test molecules that medicinal chemists designed, whereas against Plasmodium falciparum (Malaria), it reproduced 28% of 1240 test molecules. When coupled with a scoring function, our model can perform the complete de novo drug design cycle to generate large sets of novel molecules for drug discovery. PMID:29392184

Quality Management and Building Government Information Services.

ERIC Educational Resources Information Center

Farrell, Maggie

1998-01-01

Discusses serving library-patron needs in terms of customer service and quality control. Highlights include tools for measuring the quality of service (e.g., the SERVQUAL survey), advisory boards or focus groups, library "service statements," changing patron needs, new information formats, and justifying depository library services. (JAK)

Can Library Use Enhance Intercultural Education?

ERIC Educational Resources Information Center

Pihl, Joron

2012-01-01

This article explores the questions to what extent educational research addresses library use in education and how the library can contribute to intercultural education. The focus is primarily on elementary education in Europe. Analysis of research publications was based on searches for peer-reviewed journals in international databases, literary…

Negotiating the Digital Library: Document Delivery.

ERIC Educational Resources Information Center

Jacobs, Neil; Morris, Anne

1999-01-01

The eLib-funded FIDDO (Focused Investigation of Document Delivery Options) project provides library managers/others with information to support policy decisions. Senior libraries were interviewed about the future of document delivery and interviews were analyzed with the support of NUD*IST (Nonnumerical Unstructured Data by Indexing, Searching and…

Research Library Issues: A Report from ARL, CNI, and SPARC. RLI 283

ERIC Educational Resources Information Center

Baughman, M. Sue, Ed.

2013-01-01

"Research Library Issues" ("RLI") focuses on current and emerging topics that are strategically important to research libraries. The articles explore issues, share information, pose critical questions, and provide examples. This issue includes the following articles: (1) Special at the Core: Aligning, Integrating, and…

Automated System Marketplace 1988: Focused on Fulfilling Commitments.

ERIC Educational Resources Information Center

Walton, Robert A.; Bridge, Frank R.

1989-01-01

Analyzes trends in the library automation marketplace. Market shares for online vendors are examined in terms of total installations, academic libraries, public libraries, revenues, differently sized systems, and foreign installations. Hardware availability, operating systems, and interfaces with MARC are also discussed for each vendor. A source…

Libraries and Adult Learners.

ERIC Educational Resources Information Center

Josey, E. J., Ed.

1982-01-01

Of the 13 essays presented in this special issue on libraries and adult education, 8 focus on programs and services from the public library for adult learners. These essays provide information on: (1) an Education Information Centers Program (EIC) designed to complement employment skills training provided under the Comprehensive Employment and…

Access and Ownership in the Academic Environment: One Library's Progress Report.

ERIC Educational Resources Information Center

Brin, Beth; Cochran, Elissa

1994-01-01

Describes the methodology used at the University of Arizona Library to address the issue of access versus ownership of library materials. Topics discussed include participatory management; data collection, including focus groups, interlibrary loan statistics, and graduate research citation analysis; and resulting recommendations, including…

Determining and Communicating the Value of the Special Library.

ERIC Educational Resources Information Center

Matthews, Joseph R.

2003-01-01

Discusses performance measures for libraries that will indicate the goodness of the library and its services. Highlights include a general evaluation model that includes input, process, output, and outcome measures; balanced scorecard approach that includes financial perspectives; focusing on strategy; strategies for change; user criteria for…

How To Achieve Good Library Acoustics.

ERIC Educational Resources Information Center

Wiens, Janet

2003-01-01

Discusses how to create a good acoustical environment for college libraries, focusing on requirements related to the HVAC system and lighting, and noting the importance of good maintenance. A sidebar looks at how to design and achieve the most appropriate HVAC and lighting systems for optimum library acoustics. (SM)

Countdown to a New Library: Managing the Building Project.

ERIC Educational Resources Information Center

Woodward, Jeannette

This book outlines information needed to embark on a library building project, serving as an overview of the entire process, not merely focusing on the librarian's traditional role. The book begins by discussing ways librarians can prepare themselves and their staff to function effectively in the midst of a building project. Chapter 2 focuses on…

Critical Information Literacy beyond the University: Lessons from Service in a Women's Health Interest Group

ERIC Educational Resources Information Center

Fountain, Kathleen Carlisle

2013-01-01

Library instruction methods most frequently focus on teaching students searching skills to navigate the maze of library databases to locate appropriate research materials. The current theory of critical information literacy instruction calls on librarians to spend more of their time in the classroom focused on understanding the social, political,…

The Best of the Recent Literature Focusing on the User

ERIC Educational Resources Information Center

Voeller, Stacy L.

2008-01-01

The author's focus for this column within the large universe of the public services literature is on articles which stress what is best for the user. That may mean finding out why faculty use or do not use the physical library, considering the elimination of the reference desk, beginning or enhancing a library's virtual reference services, or…

A Proposal for Change: The Miller F. Whittaker Library's Long Range Program, 1985-1995. Revised.

ERIC Educational Resources Information Center

Smalls, Mary L.

This document presents an outline of a 10-year (1985-1995) library program proposal for an academic library. Six areas crucial to dealing with a changing academic library environment are analyzed as they relate to internal and external change factors. These factors, which focus on meeting the information needs of users for a new century, include:…

Why Do Staff of Joint-Use Libraries Sometimes Fail to Integrate? Investigating Cultures and Ethics in a Public-Tertiary Joint-Use Library

ERIC Educational Resources Information Center

Calvert, Philip James

2010-01-01

Joint-use libraries have identified staff integration as a problem. Using focus groups, this project investigated the culture, professional ethics, and attitudes of staff in a public-tertiary joint-use library in Auckland, New Zealand. Findings show some difference in organizational cultures, but more variation at the lower level of roles and…

IOLS '98. Proceedings of the National Conference on Integrated Online Library Systems (13th, New York, New York, May 13-14, 1998).

ERIC Educational Resources Information Center

Cibbarelli, Pamela R., Comp.; Nixon, Carol, Comp.

Integrated Online Library Systems (IOLS) focuses exclusively on the issues of planning and managing automated systems in libraries and information centers. The theme of the IOLS '98 annual meeting is "Embrace and Extend," and 18 papers were selected for presentation that provide insight into the current technologies being "embraced" in libraries.…

The Planetary Terrestrial Analogues Library (PTAL)

NASA Astrophysics Data System (ADS)

Werner, S. C.; Dypvik, H.; Poulet, F.; Rull Perez, F.; Bibring, J.-P.; Bultel, B.; Casanova Roque, C.; Carter, J.; Cousin, A.; Guzman, A.; Hamm, V.; Hellevang, H.; Lantz, C.; Lopez-Reyes, G.; Manrique, J. A.; Maurice, S.; Medina Garcia, J.; Navarro, R.; Negro, J. I.; Neumann, E. R.; Pilorget, C.; Riu, L.; Sætre, C.; Sansano Caramazana, A.; Sanz Arranz, A.; Sobron Grañón, F.; Veneranda, M.; Viennet, J.-C.; PTAL Team

2018-04-01

The Planetary Terrestrial Analogues Library project aims to build and exploit a spectral data base for the characterisation of the mineralogical and geological evolution of terrestrial planets and small solar system bodies.

Increased Diversity of Libraries from Libraries: Chemoinformatic Analysis of Bis-Diazacyclic Libraries

PubMed Central

López-Vallejo, Fabian; Nefzi, Adel; Bender, Andreas; Owen, John R.; Nabney, Ian T.; Houghten, Richard A.; Medina-Franco, Jose L.

2011-01-01

Combinatorial libraries continue to play a key role in drug discovery. To increase structural diversity, several experimental methods have been developed. However, limited efforts have been performed so far to quantify the diversity of the broadly used diversity-oriented synthetic (DOS) libraries. Herein we report a comprehensive characterization of 15 bis-diazacyclic combinatorial libraries obtained through libraries from libraries, which is a DOS approach. Using MACCS keys, radial and different pharmacophoric fingerprints as well as six molecular properties, it was demonstrated the increased structural and property diversity of the libraries from libraries over the individual libraries. Comparison of the libraries to existing drugs, NCI Diversity and the Molecular Libraries Small Molecule Repository revealed the structural uniqueness of the combinatorial libraries (mean similarity < 0.5 for any fingerprint representation). In particular, bis-cyclic thiourea libraries were the most structurally dissimilar to drugs retaining drug-like character in property space. This study represents the first comprehensive quantification of the diversity of libraries from libraries providing a solid quantitative approach to compare and contrast the diversity of DOS libraries with existing drugs or any other compound collection. PMID:21294850

The Library and the Pluralistic Campus in the Year 2000: Implications for Administrators.

ERIC Educational Resources Information Center

Welch, Janet E.; Lam, R. Errol

1991-01-01

Discussion of changing demographics and implications for academic libraries focuses on the expected increases in the numbers of Blacks and international students. Educational trends are discussed; and program ideas for academic libraries preparing for a multicultural environment are suggested, including sensitivity training for staff, minority…

Voice Technologies in Libraries: A Look into the Future.

ERIC Educational Resources Information Center

Lange, Holley R., Ed.; And Others

1991-01-01

Discussion of synthesized speech and voice recognition focuses on a forum that addressed the potential for speech technologies in libraries. Topics discussed by three contributors include possible library applications in technical processing, book receipt, circulation control, and database access; use by disabled and illiterate users; and problems…

Which Way Do You Want To Serve Your Customers?

ERIC Educational Resources Information Center

Gupta, Dinesh K.; Jambheykar, Ashok

2002-01-01

Discusses the need to focus on customer service in libraries. Topics include motivating factors, including the value of library services as judged by the users; attributes of customer service; categories of customer service; identifying users; and questions to ask library staff to help evaluate their customer service. (LRW)

NREN for All: Insurmountable Opportunity.

ERIC Educational Resources Information Center

Polly, Jean Armour

1993-01-01

Discussion of the NREN (National Research and Education Network) and issues of access focuses on the role of the public library. Highlights include current uses of the Internet; resource sharing; guidelines for public library service; availability of the Internet and NREN through public libraries; and a sidebar that lists sources of further…

School Library Media Program Connections for Learning.

ERIC Educational Resources Information Center

Bookmark, 1991

1991-01-01

The 29 articles in this theme issue of "The Bookmark" focus on various aspects of school library media programs. The articles are as follows: (1) "School Library Media Program Connections for Learning" (Betty J. Morris); (2) "Humanity and Technology in the School of the Future" (Michael V. McGill); (3) "Community…

The Electronic Age and Libraries: Present Problems and Future Prospects.

ERIC Educational Resources Information Center

Igwe, P. O. E.

1986-01-01

Summarizes impact of the electronic age and role of the library focusing on the situation in Nigeria and concern for the new age; problems of Nigerian libraries and librarians (developing economy, responsibility for development, political situation, technological problems, lack of personnel); future prospects; and suggestions for present.…

What Do Stakeholders Know about School Library Programs? Results of a Focus Group Evaluation

ERIC Educational Resources Information Center

Everhart, Nancy

2014-01-01

Supporting the "Infrastructure Needs of 21st Century School Library Programs," also known as the Pennsylvania School Library Project, was a one-year project conducted in Pennsylvania to better identify and understand what stakeholders--teachers, administrators, parents, school and community leaders, and education associations--expect…

Changing Services and Space at an Academic Library

ERIC Educational Resources Information Center

Bradigan, Pamela S.; Rodman, Ruey L.

2006-01-01

This paper focuses on how an academic library managed changes in services and space to meet customer needs for streamlined services, increasing efficiency for students, faculty and staff in finding, analyzing, sharing, and producing knowledge. The Ohio State University's John A. Prior Health Sciences Library (PHSL) has merged its circulation and…

A Literature Review of Academic Library Web Page Studies

ERIC Educational Resources Information Center

Blummer, Barbara

2007-01-01

In the early 1990s, numerous academic libraries adopted the web as a communication tool with users. The literature on academic library websites includes research on both design and navigation. Early studies typically focused on design characteristics, since websites initially merely provided information on the services and collections available in…

Science Library User Survey Report, University of California, Santa Cruz.

ERIC Educational Resources Information Center

Wei, Wei

A survey of 136 science faculty, graduate, and undergraduate students, and focus group interviews, provided perceptions and input to be used to rethink the science library's organizational structure and services. Users felt the following to be important library services: consulting the Melvyl databases; borrowing books; interlibrary loan services;…

Opening up Library Automation Software

ERIC Educational Resources Information Center

Breeding, Marshall

2009-01-01

Throughout the history of library automation, the author has seen a steady advancement toward more open systems. In the early days of library automation, when proprietary systems dominated, the need for standards was paramount since other means of inter-operability and data exchange weren't possible. Today's focus on Application Programming…

The Trend toward Retirement Jobs

ERIC Educational Resources Information Center

Buddy, Juanita Warren

2008-01-01

Many library media specialists are deciding to return to the workplace after retiring from full-time employment. This article focuses on general information about the trend of retirees acquiring retirement jobs, how and why retired library media specialists return to work, their perceptions of challenges facing library media programs, and advice…

The Integrated Library System of the 1990s: The OhioLINK Experience.

ERIC Educational Resources Information Center

Hawks, Carol Pitts

1992-01-01

Discussion of integrated library systems focuses on the development of the Ohio Library and Information Network (OhioLINK). Capabilities of eight existing systems are described, including catalog creation and maintenance; the online public access catalog (OPAC); circulation, interlibrary loan, and document delivery; acquisitions and serials…

Washington Public Libraries Online: Collaborating in Cyberspace.

ERIC Educational Resources Information Center

Wildin, Nancy

1997-01-01

Discussion of public libraries, the Internet, and the World Wide Web focuses on development of a Web site in Washington. Highlights include access to the Internet through online public access catalogs; partnerships between various types of libraries; hardware and software; HTML training; content design; graphics design; marketing; evaluation; and…

Student Workers: Essential Partners in the Twenty-First Century Academic Library

ERIC Educational Resources Information Center

Logan, Firouzeh

2012-01-01

This article describes a case study that best illustrates the value of student workers in university libraries, focusing particularly on how this kind of creative endeavor benefits everyone involved--the library, the students, the faculty, and at the end of the project: the university community. (Contains 1 table.)

Interior Design Factors in Library Facilities.

ERIC Educational Resources Information Center

Jackson, Patricia Ann

When planning the interior of a library facility, the planning team of librarian, library consultant, architect, and interior design consultant must focus attention on the basic principles of interior design and the psychological needs of the user. Colors for an interior should be selected with careful regard to space, light, and emotional and…

College and University Mergers: Impact on Academic Libraries in China.

ERIC Educational Resources Information Center

Huang, Hong-Wei

2000-01-01

Discussion of mergers in China between individual colleges and universities and much larger universities that have been a part of China's higher education reform focuses on the influence on academic libraries. Topics include collections; acquisitions; staffing; services; funding; resource sharing; library administration; online cataloging systems;…

Teaching Critical Thinking in a Library Credit Course.

ERIC Educational Resources Information Center

Poirier, Gayle; Hocker, Susan

1993-01-01

Discussion of critical thinking skills focuses on the academic library's role in teaching critical thinking skills based on experiences with a library resources course at Louisiana State University. Teaching techniques are discussed, sample lessons are described, and evaluation of students' research papers and student retention of skills are…

Factors Influencing Competence and Performance of Reference Librarians in Academic Libraries in Nigeria.

ERIC Educational Resources Information Center

Omoniyi, Joseph O.

2002-01-01

Reports on research that focused on competence and performance of reference libraries in academic libraries in Nigeria. Includes recommendations for improving competence and performance, including the reference process; staffing and other resources; education for reference librarians; knowledge of modern technology; and emotional stability and…

The Management of Retrenchment in Canadian Academic Libraries.

ERIC Educational Resources Information Center

Denis, Laurent-G.; Auster, Ethel

This exploratory study focuses on the management of decline as characterized by shrinking resources and substantial reductions in operating budgets (retrenchment) in academic research libraries in Canada. The first of four major sections of the report addresses the management of retrenchment in Canadian research libraries, including the design of…

Imagination and the Magic of Libraries.

ERIC Educational Resources Information Center

The Bookmark, 1990

1990-01-01

This issue of "The Bookmark" presents 20 articles focusing on the theme that libraries foster imagination. The articles are: (1) "Imagination and the Magic of Libraries" (Elizabeth S. Manion); (2) "Powerful Partners--Discovery and Democracy, An Interview with Cynthia Jenkins" (Anne E. Simon); (3) "Fostering Imagination in Children" (Susan Lehr);…

Are We There Yet? Evaluating Library Collections, Reference Services, Programs, and Personnel.

ERIC Educational Resources Information Center

Robbins-Carter, Jane; Zweizig, Douglas L.

1985-01-01

This second in a five-lesson tutorial on library evaluation focuses on the evaluation of library collections. Highlights include the seven-step evaluation process described in lesson one; quantitative methods (total size, unfilled requests, circulation, turnover rate); and qualitative methods (impressionistic, list-checking). One required and…

Beyond the Revitalizing High School Libraries Initiative

ERIC Educational Resources Information Center

Marczynski, Paula Townsend

2009-01-01

In 2003 the Public Education Network developed the pilot Revitalizing High School Libraries (RHSL) initiative, funded by The New York Life Foundation. Based on the Library Power Program, it included many of the same features--collaborative planning, flexible scheduling, collection development, and facility renovation--with a focus on how this…

Multi-Media and the Changing School Library; A Summary of the Preparations for, Presentations, and Group Reports of the School Library Workshop for Leadership Personnel, Held at the Monte Corona Conference Center, Twin Peaks, Calif., August 6-12, 1967.

ERIC Educational Resources Information Center

Brown, James W., Comp; And Others

The 1967 Monte Corona School Library Workshop for Leadership Personnel, seventh in a series of summer workshops, focuses on school library programs and services; particularly as these relate to a cross-media approach to curriculum implementation. This workshop is designed primarily for school library and audio-visual education leadership personnel…

Opportunity 2000: Understanding and Serving Users in an Electronic Library. Proceedings of the International Essen Symposium (15th, Essen, Germany, October 12-15, 1992) To Commemorate the 20th Anniversary of the Essen University Library. Publications of Essen University Library 15.

ERIC Educational Resources Information Center

Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

Following a prefatory tribute to distinguished librarian Herbert S. White, this publication includes the following papers, mainly focused on user needs and library services in the electronic library age: "Information Technology, Users, and Intermediaries in the 21st Century: Some Observations and Predictions" (Herbert S. White);…

The SciELO Brazilian Scientific Journal Gateway and Open Archives; Usability of Hypermedia Educational e-Books; Building Upon the MyLibrary Concept To Better Meet the Information Needs of College Students; Open Archives and UK Institutions; The Utah Digital Newspapers Project; Examples of Practical Digital Libraries.

ERIC Educational Resources Information Center

Marcondes, Carlos Henrique; Sayao, Luis Fernando; Diaz, Paloma; Gibbons, Susan; Pinfield, Stephen; Kenning, Arlitsch; Edge, Karen; Yapp, L.; Witten, Ian H.

2003-01-01

Includes six articles that focus on practical uses of technologies developed from digital library research in the areas of education and scholarship reflecting the international impact of digital library research initiatives. Includes the Scientific Electronic Library Online (SciELO) (Brazil); the National Science Foundation (NSF) (US); the Joint…

Library Space: Assessment and Planning through a Space Utilization Study.

PubMed

Prentice, Katherine A; Argyropoulos, Erica K

2018-01-01

The objective of this article is to describe the recent space and furniture utilization study conducted through direct observation at the small, academic-centered Schusterman Library. Student workers from the library's reference desk monitored two semesters of use and went on to observe a third semester after electrical power upgrades were installed. Extensive use details were collected about where library patrons sat during which parts of the day, and certain areas of the library were ultimately identified as much more active than others. Overall, the information gathered proved useful to library planning and will be valuable to future space initiatives. This article further demonstrates feasible means for any library to implement a similar study with minimal resources.

Health sciences libraries in Kuwait: a study of their resources, facilities, and services

PubMed Central

Al-Ansari, Husain A.; Al-Enezi, Sana

2001-01-01

The purpose of this study was to examine the current status of health sciences libraries in Kuwait in terms of their staff, collections, facilities, use of information technology, information services, and cooperation. Seventeen libraries participated in the study. Results show that the majority of health sciences libraries were established during the 1980s. Their collections are relatively small. The majority of their staff is nonprofessional. The majority of libraries provide only basic information services. Cooperation among libraries is limited. Survey results also indicate that a significant number of health sciences libraries are not automated. Some recommendations for the improvement of existing resources, facilities, and services are made. PMID:11465688

Principles and application of antibody libraries for infectious diseases.

PubMed

Lim, Bee Nar; Tye, Gee Jun; Choong, Yee Siew; Ong, Eugene Boon Beng; Ismail, Asma; Lim, Theam Soon

2014-12-01

Antibodies have been used efficiently for the treatment and diagnosis of many diseases. Recombinant antibody technology allows the generation of fully human antibodies. Phage display is the gold standard for the production of human antibodies in vitro. To generate monoclonal antibodies by phage display, the generation of antibody libraries is crucial. Antibody libraries are classified according to the source where the antibody gene sequences were obtained. The most useful library for infectious diseases is the immunized library. Immunized libraries would allow better and selective enrichment of antibodies against disease antigens. The antibodies generated from these libraries can be translated for both diagnostic and therapeutic applications. This review focuses on the generation of immunized antibody libraries and the potential applications of the antibodies derived from these libraries.

Selected List of Books and Journals for the Small Medical Library *

PubMed Central

Brandon, Alfred N.

1973-01-01

This updated list of 410 books and 136 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. Items suggested for first purchase by smaller libraries are noted by an asterisk. To purchase the entire collection of books and to pay for the annual subscription costs of all the journals would require an expenditure of about $12,000. To acquire only those items suggested for first purchase, approximately $3,250 would be needed. PMID:4702804

Selected list of books and journals for the small medical library.

PubMed

Brandon, A N

1973-04-01

This updated list of 410 books and 136 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. Items suggested for first purchase by smaller libraries are noted by an asterisk. To purchase the entire collection of books and to pay for the annual subscription costs of all the journals would require an expenditure of about $12,000. To acquire only those items suggested for first purchase, approximately $3,250 would be needed.

Strategy to discover diverse optimal molecules in the small molecule universe.

PubMed

Rupakheti, Chetan; Virshup, Aaron; Yang, Weitao; Beratan, David N

2015-03-23

The small molecule universe (SMU) is defined as a set of over 10(60) synthetically feasible organic molecules with molecular weight less than ∼500 Da. Exhaustive enumerations and evaluation of all SMU molecules for the purpose of discovering favorable structures is impossible. We take a stochastic approach and extend the ACSESS framework ( Virshup et al. J. Am. Chem. Soc. 2013 , 135 , 7296 - 7303 ) to develop diversity oriented molecular libraries that can generate a set of compounds that is representative of the small molecule universe and that also biases the library toward favorable physical property values. We show that the approach is efficient compared to exhaustive enumeration and to existing evolutionary algorithms for generating such libraries by testing in the NKp fitness landscape model and in the fully enumerated GDB-9 chemical universe containing 3 × 10(5) molecules.

Strategy To Discover Diverse Optimal Molecules in the Small Molecule Universe

PubMed Central

2015-01-01

The small molecule universe (SMU) is defined as a set of over 1060 synthetically feasible organic molecules with molecular weight less than ∼500 Da. Exhaustive enumerations and evaluation of all SMU molecules for the purpose of discovering favorable structures is impossible. We take a stochastic approach and extend the ACSESS framework (Virshup et al. J. Am. Chem. Soc.2013, 135, 7296–730323548177) to develop diversity oriented molecular libraries that can generate a set of compounds that is representative of the small molecule universe and that also biases the library toward favorable physical property values. We show that the approach is efficient compared to exhaustive enumeration and to existing evolutionary algorithms for generating such libraries by testing in the NKp fitness landscape model and in the fully enumerated GDB-9 chemical universe containing 3 × 105 molecules. PMID:25594586

Three-Dimensional (3D) Printers in Libraries: Perspective and Preliminary Safety Analysis

ERIC Educational Resources Information Center

Bharti, Neelam; Singh, Shailendra

2017-01-01

As an emerging technology, three-dimensional (3D) printing has gained much attention as a rapid prototyping and small-scale manufacturing technology around the world. In the changing scenario of library inclusion, Makerspaces are becoming a part of most public and academic libraries, and 3D printing is one of the technologies included in…

Expert Systems for Libraries at SCIL [Small Computers in Libraries]'88.

ERIC Educational Resources Information Center

Kochtanek, Thomas R.; And Others

1988-01-01

Six brief papers on expert systems for libraries cover (1) a knowledge-based approach to database design; (2) getting started in expert systems; (3) using public domain software to develop a business reference system; (4) a music cataloging inquiry system; (5) linguistic analysis of reference transactions; and (6) a model of a reference librarian.…

Disaster Management in the Church and Synagogue Library. CSLA Guide No. 18.

ERIC Educational Resources Information Center

Martin, Nadia J.

This guide is written for staff in church and synagogue libraries which traditionally have small collections, limited funding, and volunteer staff. The information in this guide provides the tools needed to create a customized disaster response plan for church or synagogue libraries. Part 1: The Disaster Response Plan, covers the process of…

A Computerized Cataloging System for an Outdoor Program Library or Resource Center.

ERIC Educational Resources Information Center

Watters, Ron

The Outdoor Resource Library Cataloging System is a computer software program designed primarily for outdoor programs with small to medium-sized resource centers. The software is free to nonprofit organizations and is available from the Idaho State University Outdoor Program. The software is used to construct a database of library materials, which…

Nurturing a Generation of Leaders: The College Library Directors' Mentor Program

ERIC Educational Resources Information Center

Hardesty, Larry

2017-01-01

The College Library Directors' Mentor Program has operated for more than 20 years, during which a substantial portion of the target audience of first-year library directors of small colleges has participated. Through this article, the authors identify the purpose of the program, describe its evolution and current status, and examine the nature of…

Streaming the Archives: Repurposing Systems to Advance a Small Media Digitization and Dissemination Program

ERIC Educational Resources Information Center

Anderson, Talea

2015-01-01

In 2013-2014, Brooks Library at Central Washington University (CWU) launched library content in three systems: a digital asset-management system, an institutional repository (IR), and a web-based discovery layer. In early 2014, the archives at the library began to use these systems to disseminate media recently digitized from legacy formats. As…

Learning Curve: Adapting Library Workspaces

ERIC Educational Resources Information Center

Haug, James C.

2008-01-01

One of the hubs of campus life at Longwood University--located in the small central Virginia town of Farmville--is the Janet D. Greenwood Library. In fall 2004, reference materials were relocated to free up space, and 15 computer workstations, which had been lined up against a wall, were replaced with 48 new PCs. In 2005, library staff began…

Synthetic Molecular Evolution of Membrane-Active Peptides

NASA Astrophysics Data System (ADS)

Wimley, William

The physical chemistry of membrane partitioning largely determines the function of membrane active peptides. Membrane-active peptides have potential utility in many areas, including in the cellular delivery of polar compounds, cancer therapy, biosensor design, and in antibacterial, antiviral and antifungal therapies. Yet, despite decades of research on thousands of known examples, useful sequence-structure-function relationships are essentially unknown. Because peptide-membrane interactions within the highly fluid bilayer are dynamic and heterogeneous, accounts of mechanism are necessarily vague and descriptive, and have little predictive power. This creates a significant roadblock to advances in the field. We are bypassing that roadblock with synthetic molecular evolution: iterative peptide library design and orthogonal high-throughput screening. We start with template sequences that have at least some useful activity, and create small, focused libraries using structural and biophysical principles to design the sequence space around the template. Orthogonal high-throughput screening is used to identify gain-of-function peptides by simultaneously selecting for several different properties (e.g. solubility, activity and toxicity). Multiple generations of iterative library design and screening have enabled the identification of membrane-active sequences with heretofore unknown properties, including clinically relevant, broad-spectrum activity against drug-resistant bacteria and enveloped viruses as well as pH-triggered macromolecular poration.

In their own words: oral histories of Medical Library Association past presidents*

PubMed Central

Epstein, Barbara A.

2016-01-01

Objective The purpose of this lecture was to review the development of the Medical Library Association (MLA) oral history program and to highlight the oral histories of thirty-seven past MLA presidents to identify themes of common interest and relevance to current MLA members. Methods The lecture focused on three main topics discussed in many of the interviews: the presidents' backgrounds and how they came to be medical librarians, how MLA developed as an organization as a reflection of the growth of medical libraries, and the presidents' predictions and advice about the future. Results MLA presidents came from varied backgrounds and locales. As MLA grew from a small, intimate group into a multifaceted organization with a professional management staff, the workload of the presidents changed in scope. One recurring theme in the presidential oral histories was the power differential between men and women in the organization and the profession. MLA presidents reminisced about notable annual meetings and praised the positive impact of the organization on members' professional and personal lives. Conclusions The lecture concludes with recommendations to the organization to increase the availability of the oral histories by providing online access for future interviews and to pay careful attention to their long-term preservation. PMID:26807047

Basic reference aids for small medical libraries.

PubMed

Blair, E D

1967-04-01

Selected primarily for the small medical library, this list is compiled to serve as a practical guide for the librarian in developing and utilizing an effective reference collection. Arrangement is by broad subject groups; titles chosen are chiefly in English with geographic coverage limited to the United States and Canada. Texts in subject fields have been omitted since these are adequately covered in several comprehensive guides to the literature.

Longview Public Library Final Performance Report for Library Services and Construction Act (LCSA) Title VI Library Literacy Program.

ERIC Educational Resources Information Center

Longview Public Library, WA.

Project Read at the Longview (Washington) Public Library conducted a program to maintain and expand the Family Literacy Center to provide a monitored tutoring site and family outreach program for a minimum of 75 adult learners and 40 tutors. Two projects were involved: (1) Project READ focused on adult learners with a one-on-one tutoring approach;…

International Federation of Library Associations Annual Conference. Papers of the Management and Technology Division: Information Technology Section (47th, Leipzig, East Germany, August 17-22, 1981).

ERIC Educational Resources Information Center

Bradler, Reinhard; And Others

These seven papers on library management and networks focus on: (1) computerized access to archival and library materials, describing the methodological problems associated with a pilot project in the German Democratic Republic, as well as the efficiency of data bank systems; (2) present and future development of libraries and information centers…

The Challenge of Technology: Action Strategies for the School Library Media Specialist. School Library Media Programs: Focus on Trends and Issues; No. 13.

ERIC Educational Resources Information Center

Wright, Kieth

This book describes some of the challenges facing school library media specialists as they work with teachers and administrators in making appropriate use of computers in schools. Five chapters address the following topics: (1) the school in the context of the emerging information society; (2) the roles of school library media specialists in the…

Survey of Library and Information Problems in Correctional Institutions. Volume 1: Findings and Recommendations. ILR-73-008. Final Report.

ERIC Educational Resources Information Center

LeDonne, Marjorie

On-site visits were made to all federal and some state prisons in 10 selected states to provide current information on which decisions could be based for prison library and information services. The focus was on the broad issues of library goals and objectives, relationship of the library to the total institution and the outside community, the…

Planning LIS Doctoral Education around a Focused Theme: A Report on the B2A Program

ERIC Educational Resources Information Center

Bennett-Kapusniak, Renee; McCleer, Adriana; Glover, Jeannette; Thiele, Jennifer; Wolfram, Dietmar

2016-01-01

This report discusses the Overcoming Barriers to Information Access (B2A) program. This is a doctoral cohort program at the University of Wisconsin-Milwaukee funded by the Institute for Museum and Library Services. The program has focused on educating the next generation of doctoral graduates in library and information science with an emphasis on…

Synergy: Creating a Library Website with Social Interaction and a Collection Focus

ERIC Educational Resources Information Center

Kiyotake, Cynthia

2010-01-01

Since launching its first website in 1997, the Arapahoe Library District (ALD) has constantly looked at ways to review and renew this vital tool for patrons. This article focuses on the process of redesigning the ALD website--the steps taken and decisions made in order to create a site that incorporates interactive elements and patron input and…

The MAGIC of Web Tutorials: How One Library (Re)Focused Its Delivery of Online Learning Objects on Users

ERIC Educational Resources Information Center

Hess, Amanda Nichols

2013-01-01

Oakland University (OU) Libraries undertook an assessment of how to leverage its resources to make online tutorials more focused on users' needs. A multi-part assessment process reconsidered Web tutorials offerings through the lenses of faculty and staff feedback, literature review, and an analysis of other universities' online tutorial offerings.…

Molecular computational elements encode large populations of small objects

NASA Astrophysics Data System (ADS)

Prasanna de Silva, A.; James, Mark R.; McKinney, Bernadine O. F.; Pears, David A.; Weir, Sheenagh M.

2006-10-01

Since the introduction of molecular computation, experimental molecular computational elements have grown to encompass small-scale integration, arithmetic and games, among others. However, the need for a practical application has been pressing. Here we present molecular computational identification (MCID), a demonstration that molecular logic and computation can be applied to a widely relevant issue. Examples of populations that need encoding in the microscopic world are cells in diagnostics or beads in combinatorial chemistry (tags). Taking advantage of the small size (about 1nm) and large `on/off' output ratios of molecular logic gates and using the great variety of logic types, input chemical combinations, switching thresholds and even gate arrays in addition to colours, we produce unique identifiers for members of populations of small polymer beads (about 100μm) used for synthesis of combinatorial libraries. Many millions of distinguishable tags become available. This method should be extensible to far smaller objects, with the only requirement being a `wash and watch' protocol. Our focus on converting molecular science into technology concerning analog sensors, turns to digital logic devices in the present work.

Molecular computational elements encode large populations of small objects.

PubMed

de Silva, A Prasanna; James, Mark R; McKinney, Bernadine O F; Pears, David A; Weir, Sheenagh M

2006-10-01

Since the introduction of molecular computation, experimental molecular computational elements have grown to encompass small-scale integration, arithmetic and games, among others. However, the need for a practical application has been pressing. Here we present molecular computational identification (MCID), a demonstration that molecular logic and computation can be applied to a widely relevant issue. Examples of populations that need encoding in the microscopic world are cells in diagnostics or beads in combinatorial chemistry (tags). Taking advantage of the small size (about 1 nm) and large 'on/off' output ratios of molecular logic gates and using the great variety of logic types, input chemical combinations, switching thresholds and even gate arrays in addition to colours, we produce unique identifiers for members of populations of small polymer beads (about 100 microm) used for synthesis of combinatorial libraries. Many millions of distinguishable tags become available. This method should be extensible to far smaller objects, with the only requirement being a 'wash and watch' protocol. Our focus on converting molecular science into technology concerning analog sensors, turns to digital logic devices in the present work.

Synthesis of small combinatorial libraries of natural products: identification and quantification of new long-chain 3-methyl-2-alkanones from the root essential oil of Inula helenium L. (Asteraceae).

PubMed

Radulović, Niko S; Denić, Marija S; Stojanović-Radić, Zorica Z

2014-01-01

Recently, a potent anti-staphylococcal activity of Inula helenium L. (Asteraceae) root essential oil was reported. Also, bioassay guided fractionation of the oil pointed to eudesmane sesquiterpene lactones and a series of unidentified constituents as the main carriers of the observed activity. To identify nine new constituents (long-chain 3-methyl-2-alkanones) from a fraction of this root essential oil with a low minimum inhibitory concentration value (0.8 µg/mL) by employing a synthetic methodology that leads to the formation of a small combinatorial library of these compounds. The identity of these constituents was inferred from mass spectral fragmentation patterns and GC retention data. A library of 3-methyl-2-alkanones (C11 -C19 homologous series) was synthesised in three steps starting from methyl acetoacetate and the corresponding alkyl halides. The synthetic library was also screened for in vitro anti-microbial activity. Gas chromatographic analyses of I. helenium essential oil samples with spiked compounds from the synthesised library corroborated the tentative identifications of the long-chain 3-methyl-2-alkanones. The availability of these anti-microbial compounds from this library made it possible to construct GC/FID calibration curves and determine their content in the plant material: 0.08 - 24.2 mg/100 g of dry roots. The small combinatorial library approach enabled the first unequivocal identification of long-chain 3-methyl-2-alkanones as plant secondary metabolites, and, also, allowed determination of not only a single compound and biological properties, but those of a group of structurally related compounds. Copyright © 2013 John Wiley & Sons, Ltd.

Library Literature in English-Speaking West Africa; Its Achievements, Problems and Prospects.

ERIC Educational Resources Information Center

Nyarko, K.

This report surveys the development of librarianship in West Africa since 1954, focusing primarily on the production of professional library literature in Gambia, Ghana, Nigeria, Sierra Leone, and Liberia, the five countries which constitute the sub-region of English-speaking West Africa. An overview of library developments is presented, and three…

Practitioners' & LIS Students' Perceptions on Preparedness in the New York Metropolitan Area

ERIC Educational Resources Information Center

Creel, Stacy L.; Pollicino, Elizabeth B.

2012-01-01

This paper discusses the results of a study that focused on the perceived preparedness of recent graduates. Fifty-five St. John's University MLS students surveyed 348 practitioners in public libraries (181) and school libraries (167) concerning perceived preparedness of recent MLS graduates for the realities of working in libraries. The overriding…

The Emergence of the Collective Collection: Analyzing Aggregate Print Library Holdings

ERIC Educational Resources Information Center

Dempsey, Lorcan

2013-01-01

As the network continues to reconfigure personal, business, and institutional relationships, it is natural that we also continue to see changes in how library collections are managed: changes in focus, boundaries, and value. One important trend is that libraries and the organizations that provide services to them will devote more attention to…

Examination of the Nexus between Academic Libraries and Accreditation: Lessons from Nigeria

ERIC Educational Resources Information Center

Nkiko, Christopher; Ilo, Promise; Idiegbeyan-Ose, Jerome; Segun-Adeniran, Chidi

2015-01-01

The article investigated the nexus between academic libraries and accreditation in the higher institutions with special focus on the Nigerian experience. It showed that all accreditation agencies place a high premium on library provisions as a major component of requisite benchmarks in determining the status of the program or institutions being…

Access to Everything: Building the Future Academic Library Collection

ERIC Educational Resources Information Center

Levine-Clark, Michael

2014-01-01

Academic libraries have always been deeply associated with their collections, but the nature of those collections has changed radically as we have entered the digital age. As libraries continue to evolve, they will focus strongly on special collections while adopting a goal of providing access to as much other content as possible. The collection…

Designing a Decision Support System (DSS) for Academic Library Managers Using Preprogrammed Application Software on a Microcomputer.

ERIC Educational Resources Information Center

McDonald, Joseph

1986-01-01

Focusing on management decisions in academic libraries, this article compares management information systems (MIS) with decision support systems (DSS) and discusses the decision-making process, information needs of library managers, sources of data, reasons for choosing microcomputer, preprogrammed application software, prototyping a system, and…

Readers on the Prowl: Florida Library Youth Program Manual.

ERIC Educational Resources Information Center

Johnson, Margie, Comp.; Cook, Ann, Comp.; O'Reilly, Lesley, Comp.

This manual is designed to accompany the 1999 Florida Library Youth Program, focusing on the theme of the library as a destination. This introductory section of the manual contains: an overview of the program that discusses basic philosophy, outreach to children in poverty, age and ability levels, and materials and incentives; a schedule of…

Idaho's Library Future.

ERIC Educational Resources Information Center

Idaho State Library, Boise.

In l998, Idahoans gathered in a series of six Regional Futures Conferences to identify what they thought was probable during the next ten years, what was possible for libraries to do and be, and what a preferred future of Idaho libraries might be. Participants from the regional conferences then convened to refine and focus descriptions of the…

A Tour of the Stacks--HyperCard for Libraries.

ERIC Educational Resources Information Center

Ertel, Monica; Oros, Jane

1989-01-01

Description of HyperCard, a software package that runs on Macintosh microcomputers, focuses on its use in the Apple Computer, Inc., Library as a user guide to the library. Examples of screen displays are given, and a list of resources is included to help use and understand HyperCard more completely. (LRW)

Law Library Service in the 1990's.

ERIC Educational Resources Information Center

The Bookmark, 1990

1990-01-01

This issue of "The Bookmark" presents 20 articles focusing on various aspects of law library services in New York State. The articles are: (1) "Law Library Services in the 1990's" (Christine Bain); (2) "A Librarian's View of Legal Publishing Today" (Margaret Maes Axtmann); (3) "Legal Publishing--A Publisher's View" (Kenneth Lee Halajian); (4)…

Technological Change in the Workplace: A Statewide Survey of Community College Library and Learning Resources Personnel.

ERIC Educational Resources Information Center

Poole, Carolyn E.; Denny, Emmett

2001-01-01

Discussion of the effects of technostress on library personnel focuses on an investigation that examined how employees in Florida community college libraries and learning resources centers are dealing with technological change in their work environment. Considers implications for planning and implementing technological change and includes…

Photocopy Services in ARL Libraries. SPEC Kit 115.

ERIC Educational Resources Information Center

McCool, Donna L.

To gather information about the nature of photocopy services in academic libraries and issues relating to their management, a survey was mailed to each of the 117 members of the Association for Research Libraries (ARL). The survey focused on two components of photocopy services: the self-service copiers placed at strategic locations within the…

From the Users' Perspective-The UCSD Libraries User Survey Project.

ERIC Educational Resources Information Center

Talbot, Dawn E.; Lowell, Gerald R.; Martin, Kerry

1998-01-01

Discussion of a user-driven survey conducted at the University of California, San Diego libraries focuses on the methodology that resulted in a high response rate. Highlights goals for the survey, including acceptance of data by groups outside the library and for benchmarking data; planning; user population; and questionnaire development. (LRW)

Evidence-Based Library Management: The Leadership Challenge

ERIC Educational Resources Information Center

Lakos, Amos

2007-01-01

This paper is an extension of the author's earlier work on developing management information services and creating a culture of assessment in libraries. The author will focus observations on the use of data in decision-making in libraries, specifically on the role of leadership in making evidence-based decision a reality, and will review new…

Personalized Boutique Service: Critical to Academic Library Success?

ERIC Educational Resources Information Center

Tilley, Elizabeth

2013-01-01

An academic library that focuses on delivering a personalized service is examined within the context of the boutique library model. It is suggested that a critical success factor in adopting a personalized, boutique-style service is acquiring knowledge and insight of our users. This, together with appropriate evaluation, will assist with providing…

Make Your Point: At-Risk Students as Library Assistants.

ERIC Educational Resources Information Center

Dorell, Larry D.

1992-01-01

Discussion of the dangers of labeling people focuses on the successful experience of a school media director who enlisted a student from the behavioral disorder classroom as a library assistant. Concludes that special service students can provide valuable help in the library while gaining experience that enhances their self-esteem. (NRP)

Improving the Patron Experience: Sterling Memorial Library's Single Service Point

ERIC Educational Resources Information Center

Sider, Laura Galas

2016-01-01

This article describes the planning process and implementation of a single service point at Yale University's Sterling Memorial Library. While much recent scholarship on single service points (SSPs) has focused on the virtues or hazards of eliminating reference desks in libraries nationwide, this essay explores the ways in which single service…

Customer Service Training for Public Services Staff at Temple University's Central Library System.

ERIC Educational Resources Information Center

Arthur, Gwen

Arguing that good interpersonal interactions between library staff and their patrons is a major determinant of overall patron satisfaction, this paper describes Temple University's customer service training program for its public services staff. Dubbed the "A+ Service" program, the program focuses on six aspects of library service: (1)…

Case Study: Pepperdine University Libraries' Migration to OCLC's Worldshare

ERIC Educational Resources Information Center

Dula, Michael W.; Ye, Gan

2012-01-01

In this case study the authors describe Pepperdine University Libraries' migration to OCLC's WorldShare Management Services. They elaborate on the rationale for the decision, review some of the challenges and lessons encountered along the way, and briefly discuss some effects of the new system on our libraries. The focus is on technical services…

Plagiarism Awareness among Students: Assessing Integration of Ethics Theory into Library Instruction

ERIC Educational Resources Information Center

Strittmatter, Connie; Bratton, Virginia K.

2014-01-01

The library literature on plagiarism instruction focuses on students' understanding of what plagiarism is and is not. This study evaluates the effect of library instruction from a broader perspective by examining the pre- and posttest (instruction) levels of students' perceptions toward plagiarism ethics. Eighty-six students completed a pre- and…

Purchase Recommendations for Globalizing Online Collections at Community College Libraries

ERIC Educational Resources Information Center

Harris, Annie Kadala

2016-01-01

Focused on community colleges in North Carolina participating in the Scholars of Global Distinction initiative, the goal of this article is to assist librarians in their efforts to thoughtfully increase global and area studies online resources available at their libraries. Through this article, the author hopes to increase global library resources…

Evidence-Based Practice and School Libraries: Interconnections of Evidence, Advocacy, and Actions

ERIC Educational Resources Information Center

Todd, Ross J.

2015-01-01

This author states that a professional focus on evidence based practice (EBP) for school libraries emerged from the International Association of School Librarianship conference when he presented the concept. He challenged the school library profession to actively engage in professional and reflective practices that chart, measure, document, and…

Meeting and Serving Users in Their New Work (and Play) Spaces

ERIC Educational Resources Information Center

Peters, Tom

2008-01-01

This article examines the public services component of digital and virtual libraries, focusing on the end-user experience. As the number and types of "places" where library users access library collections and services continue to expand (now including cell phones, iPods, and three-dimensional virtual reality environments populated by avatars),…

Libraries Alive: Promoting Libraries and Literature--Practical Applications for the Teacher-Librarian.

ERIC Educational Resources Information Center

Boyd, Suzette

Enthusiasm for and a commitment to literature are the essential tools needed to successfully promote the enriching, challenging, and thought-provoking world of books. This paper focuses on the promotion of literature inside the classroom, inside the library, and in the wider community. Programs at Methodist Ladies' College (Australia), a boarding…

Selection and Cataloging of Adult Pornography Web Sites for Academic Libraries

ERIC Educational Resources Information Center

Dilevko, Juris; Gottlieb, Lisa

2004-01-01

Pornography has become part of mainstream culture. As such, it has become a subject of academic research, and this, in turn, has implications for university libraries. Focusing on adult Internet pornography, this study suggests that academic libraries should provide access to adult pornographic Web sites by including them in their online catalogs.

Just Another Format: Integrating Resources for Users of Personal Digital Assistants

ERIC Educational Resources Information Center

Koufogiannakis, Denise; Ryan, Pam; Dahl, Susan

2005-01-01

This article discusses the integration of library resources for users of personal digital assistants (PDAs), with a focus on collections issues within an academic environment. The University of Alberta Libraries' PDA services initiative is used as an example of integrating services and resources into a library collection. Licensing issues, loaning…

What Do Young Teens Think about the Public Library?

ERIC Educational Resources Information Center

Howard, Vivian

2011-01-01

This article reports on a research study investigating the attitude of twelve- to fifteen-year-old residents of an Eastern Canadian regional municipality to the public library. Phase 1, a quantitative survey, analyzes overall satisfaction ratings and frequency of use of the public library. Phase 2 uses qualitative methodology (focus groups) to…

Academic Library Service to Disabled Students: Today and Tomorrow.

ERIC Educational Resources Information Center

Stone, Elizabeth W.

The presentation focuses on the status of disabled persons in the world, notes progress made in improved living conditions for the disabled, and considers implications for libraries serving disabled clients. Services currently offered in academic libraries are described, as are goals related to four aims specified by the United Nations during the…

User Education in the Academic Library: Media Methods for Reference Work. An Annotated Bibliography. Updated.

ERIC Educational Resources Information Center

Wharton, Sika

This annotated bibliography focuses on academic library usage of audiovisual (AV) methods of instruction, particularly for the enhancement of the reference teaching function. The bibliography's objectives are as follows: to identify current trends with regard to AV methods in library orientation and bibliographic instruction; to isolate instances…

Factors Influencing Virtual Patron Satisfaction with Online Library Resources and Services

ERIC Educational Resources Information Center

Tyler, Katherine; Hastings, Nancy B.

2011-01-01

College students are accessing virtual libraries whether they are on campus or learning from a distance. Academic institutions serving virtual patrons must remain focused on meeting the needs of those library users by continually examining their preferences, their searching behavior, and the information they seek. The purpose of this research was…

Factors Influencing Virtual Patron Satisfaction with Online Library Resources and Services

ERIC Educational Resources Information Center

Tyler, Katherine Mary

2010-01-01

College students are accessing virtual libraries whether they are on campus or learning from a distance. Academic institutions serving virtual patrons must remain focused on meeting the needs of those library users by continually examining their preferences, their searching behavior, and the information they seek. The purpose of this research was…

New York State's School Library Evaluation

ERIC Educational Resources Information Center

Jaeger, Paige

2012-01-01

The New York State's School Library Media Program Evaluation (SLMPE) rubric provides a window of opportunity for a librarian to talk with his/her administrators about library program elements that may be out of the librarian's control. There are three areas of focus on the SLMPE Rubric: (1) Teaching and Learning; (2) Building and Learning…

Research Library Issues: A Report from ARL, CNI, and SPARC. Special Issue on Copyright. RLI 285

ERIC Educational Resources Information Center

Baughman, M. Sue, Ed.

2015-01-01

"Research Library Issues" ("RLI") focuses on current and emerging topics that are strategically important to research libraries. The articles explore issues, share information, pose critical questions, and provide examples. This issue includes the following articles: (1) Special Issue on Copyright (Prudence S. Adler); (2) Fair…

Portal to the World: AIHEC Virtual Library Opens Doors for Native Research

ERIC Educational Resources Information Center

Kirby, Jane

2004-01-01

The Internet keeps growing at lightning speed. Now, "tribal college" students have a tool to assist them in locating accurate information quickly: the American Indian Higher Education Consortium (AIHEC) Virtual Library. The AIHEC Virtual Library provides a focused entryway into the Internet research field. Librarians report that it supplements…

Technology for libraries and information centers: A seminar in Greece, Portugal, and Turkey

NASA Technical Reports Server (NTRS)

Cotter, Gladys A.

1992-01-01

Information technologies are evolving at a rapid pace in today's world. But the electronic technologies needed to transform today's libraries and information centers into electronic 'libraries without walls', where an end-user has instantaneous access to all the information needed from a desktop workstation, have not yet arrived. Even so, there are many technologies available today that can be applied in the library/information center environment to yield increased productivity. However, not all technologies are right for or successful in every environment. Mission, budget, infrastructure, client profiles, and staff skills are a few of the 'environmental' issues that must be considered when selecting and introducing new technologies into a particular information center. Key technologies used in libraries today are reviewed; it can be used as background for targeting technologies that could be successfully implemented in your own environment to further service goals. Before focusing on a selection of technologies, you must first focus on the strategic goal of your organization. The same technology is not right for every library/information center. An overview of technologies that are readily available and can be applied today is presented.

Community-led cancer action councils in Queens, New York: process evaluation of an innovative partnership with the Queens library system.

PubMed

Basu Roy, Upal; Michel, Tamara; Carpenter, Alison; Lounsbury, David W; Sabino, Eilleen; Stevenson, Alexis Jurow; Combs, Sarah; Jacobs, Jasmine; Padgett, Deborah; Rapkin, Bruce D

2014-02-06

Community-based participatory research (CBPR) has great potential to address cancer disparities, particularly in racially and ethnically diverse and underserved neighborhoods. The objective of this study was to conduct a process evaluation of an innovative academic-community partnership, Queens Library HealthLink, which aimed to reduce cancer disparities through neighborhood groups (Cancer Action Councils) that convened in public libraries in Queens, New York. We used a mixed-methods approach to conduct 69 telephone survey interviews and 4 focus groups (15 participants) with Cancer Action Council members. We used 4 performance criteria to inform data collection: action or attention to sustainability, library support for the council, social cohesion and group leadership, and activity level. Focus group transcripts were independently coded and cross-checked for consensus until saturation was achieved. Members reported benefits and barriers to participation. Thirty-three original focus group transcript codes were organized into 8 main themes related to member experiences: 1) library as a needed resource, 2) library as a reputable and nondenominational institution, 3) value of library staff, 4) need for a HealthLink specialist, 5) generation of ideas and coordination of tasks, 6) participation challenges, 7) use of community connections, and 8) collaboration for sustainability. In response to the process evaluation, Cancer Action Council members and HealthLink staff incorporated member suggestions to improve council sustainability. The councils merged to increase intercouncil collaboration, and institutional changes were made in funding to sustain a HealthLink specialist beyond the grant period.

Addressing Library Anxiety (LA) in student nurses: a study in an NHS Foundation Trust Hospital library and information service.

PubMed

Still, Madeleine

2015-12-01

Library anxiety is a concept which has been recognised in academic library circles since the early 1990s. It can result in students actively avoiding the library for the duration of their studies. Madeleine Still is Trust Librarian at North Tees & Hartlepool NHS Foundation Trust and while studying for an MSc, recognised that some student nurses were exhibiting signs of library anxiety. She decided to make it the focus of her MSc dissertation, and this article discusses her research project as well as highlighting the measures she has taken to address the issues she uncovered. Madeleine graduated in July 2013 with an MSc in Information & Library Studies from Robert Gordon University. © 2015 Health Libraries Group.

High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density

DOE PAGES

Teplitsky, Ella; Joshi, Karan; Ericson, Daniel L.; ...

2015-07-01

We describe a high throughput method for screening up to 1728 distinct chemicals with protein crystals on a single microplate. Acoustic droplet ejection (ADE) was used to co-position 2.5 nL of protein, precipitant, and chemicals on a MiTeGen in situ-1 crystallization plate™ for screening by co-crystallization or soaking. ADE-transferred droplets follow a precise trajectory which allows all components to be transferred through small apertures in the microplate lid. The apertures were large enough for 2.5 nL droplets to pass through them, but small enough so that they did not disrupt the internal environment created by the mother liquor. Using thismore » system, thermolysin and trypsin crystals were efficiently screened for binding to a heavy-metal mini-library. Fluorescence and X-ray diffraction were used to confirm that each chemical in the heavy-metal library was correctly paired with the intended protein crystal. Moreover, a fragment mini-library was screened to observe two known lysozyme We describe a high throughput method for screening up to 1728 distinct chemicals with protein crystals on a single microplate. Acoustic droplet ejection (ADE) was used to co-position 2.5 nL of protein, precipitant, and chemicals on a MiTeGen in situ-1 crystallization plate™ for screening by co-crystallization or soaking. ADE-transferred droplets follow a precise trajectory which allows all components to be transferred through small apertures in the microplate lid. The apertures were large enough for 2.5 nL droplets to pass through them, but small enough so that they did not disrupt the internal environment created by the mother liquor. Using this system, thermolysin and trypsin crystals were efficiently screened for binding to a heavy-metal mini-library. Fluorescence and X-ray diffraction were used to confirm that each chemical in the heavy-metal library was correctly paired with the intended protein crystal. A fragment mini-library was screened to observe two known lysozyme ligands using both co-crystallization and soaking. A similar approach was used to identify multiple, novel thaumatin binding sites for ascorbic acid. This technology pushes towards a faster, automated, and more flexible strategy for high throughput screening of chemical libraries (such as fragment libraries) using as little as 2.5 nL of each component.ds using both co-crystallization and soaking. We used a A similar approach to identify multiple, novel thaumatin binding sites for ascorbic acid. This technology pushes towards a faster, automated, and more flexible strategy for high throughput screening of chemical libraries (such as fragment libraries) using as little as 2.5 nL of each component.« less

Small Is Beautiful: The Library Train for Homeless Children.

ERIC Educational Resources Information Center

Cheunwattana, Aree; Meksawat, Pimol

This paper presents the story of an effort in Thailand to reach out to children in high-risk situations by providing them with a library on old train carriages. The Library Train Project was initiated in 1999 by the Railway Police Division within the Royal Police Office. It is aimed at offering education services to homeless children as a way of…

Biology-driven library design for probe discovery.

PubMed

Inglese, James; Hasson, Samuel A

2011-10-28

Libraries of diverse small molecules are important to probe and drug discovery. The current trend toward building massive screening collections to support drug development, a special application of chemical biology, can limit their broader potential. Biology-driven construction methods (Wallace et al., 2011) are rapidly emerging to bring chemical libraries back on a viable path. Copyright © 2011 Elsevier Ltd. All rights reserved.

Include Your Patrons in Web Design. Computers in Small Libraries

ERIC Educational Resources Information Center

Roberts, Gary

2005-01-01

Successful Web publishing requires not only technical skills but also a refined sense of taste, a good understanding of design, and strong writing abilities. When designing a library Web page, a person must possess all of these talents and be able to market to a broad spectrum of patrons. As a result, library sites vary widely in their style and…

Comprehensive peptidomimetic libraries targeting protein-protein interactions.

PubMed

Whitby, Landon R; Boger, Dale L

2012-10-16

Transient protein-protein interactions (PPIs) are essential components in cellular signaling pathways as well as in important processes such as viral infection, replication, and immune suppression. The unknown or uncharacterized PPIs involved in such interaction networks often represent compelling therapeutic targets for drug discovery. To date, however, the main strategies for discovery of small molecule modulators of PPIs are typically limited to structurally characterized targets. Recent developments in molecular scaffolds that mimic the side chain display of peptide secondary structures have yielded effective designs, but few screening libraries of such mimetics are available to interrogate PPI targets. We initiated a program to prepare a comprehensive small molecule library designed to mimic the three major recognition motifs that mediate PPIs (α-helix, β-turn, and β-strand). Three libraries would be built around templates designed to mimic each such secondary structure and substituted with all triplet combinations of groups representing the 20 natural amino acid side chains. When combined, the three libraries would contain a member capable of mimicking the key interaction and recognition residues of most targetable PPIs. In this Account, we summarize the results of the design, synthesis, and validation of an 8000 member α-helix mimetic library and a 4200 member β-turn mimetic library. We expect that the screening of these libraries will not only provide lead structures against α-helix- or β-turn-mediated protein-protein or peptide-receptor interactions, even if the nature of the interaction is unknown, but also yield key insights into the recognition motif (α-helix or β-turn) and identify the key residues mediating the interaction. Consistent with this expectation, the screening of the libraries against p53/MDM2 and HIV-1 gp41 (α-helix mimetic library) or the opioid receptors (β-turn mimetic library) led to the discovery of library members expected to mimic the known endogenous ligands. These efforts led to the discovery of high-affinity α-helix mimetics (K(i) = 0.7 μM) against HIV-1 gp41 as well as high-affinity and selective β-turn mimetics (K(i) = 80 nM) against the κ-opioid receptor. The results suggest that the use of such comprehensive libraries of peptide secondary structure mimetics, built around effective molecular scaffolds, constitutes a powerful method of interrogating PPIs. These structures provide small molecule modulators of PPI networks for therapeutic target validation, lead compound discovery, and the identification of modulators of biological processes for further study.

Berlin Reflectance Spectral Library (BRSL)

NASA Astrophysics Data System (ADS)

Henckel, D.; Arnold, G.; Kappel, D.; Moroz, L. V.; Markus, K.

2017-09-01

The Berlin Reflectance Spectral Library (BRSL) provides a collection of reflectance spectra between 0.3 and 17 µm. It was originally dedicated to support space missions to small solar system bodies. Meanwhile the library includes selections of biconical reflectance spectra for spectral data analysis of other planetary bodies as well. The library provides reference spectra of well-characterized terrestrial analogue materials and meteorites for interpretation of remote sensing reflectance spectra of planetary surfaces. We introduce the BRSL, summarize the data available, and access to use them for further relevant applications.

CSlib, a library to couple codes via Client/Server messaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plimpton, Steve

The CSlib is a small, portable library which enables two (or more) independent simulation codes to be coupled, by exchanging messages with each other. Both codes link to the library when they are built, and can them communicate with each other as they run. The messages contain data or instructions that the two codes send back-and-forth to each other. The messaging can take place via files, sockets, or MPI. The latter is a standard distributed-memory message-passing library.

Public Libraries and Community-Based Education: Making the Connection for Lifelong Learning. Volume 2: Commissioned Papers. A Conference Sponsored by the National Institute on Postsecondary Education, Libraries, and Lifelong Learning, Office of Educational Research and Improvement (Washington, D.C., April 12-13, 1995).

ERIC Educational Resources Information Center

National Inst. on Postsecondary Education, Libraries, and Lifelong Learning (ED/OERI), Washington, DC.

This conference explored the relationship between the public library, community-based adult education, and lifelong learning. The eight commissioned papers presented include: "Community Based Adult Jewish Learning Program: Issues and Concerns" (Paul A. Flexner); "Rural and Small Libraries: Provisions for Lifelong Learning" (Bernard Vavrek);…

Development and Synthesis of DNA-Encoded Benzimidazole Library.

PubMed

Ding, Yun; Chai, Jing; Centrella, Paolo A; Gondo, Chenaimwoyo; DeLorey, Jennifer L; Clark, Matthew A

2018-04-25

Encoded library technology (ELT) is an effective approach to the discovery of novel small-molecule ligands for biological targets. A key factor for the success of the technology is the chemical diversity of the libraries. Here we report the development of DNA-conjugated benzimidazoles. Using 4-fluoro-3-nitrobenzoic acid as a key synthon, we synthesized a 320 million-member DNA-encoded benzimidazole library using Fmoc-protected amino acids, amines and aldehydes as diversity elements. Affinity selection of the library led to the discovery of a novel, potent and specific antagonist of the NK3 receptor.

Computational mass spectrometry for small molecules

PubMed Central

2013-01-01

The identification of small molecules from mass spectrometry (MS) data remains a major challenge in the interpretation of MS data. This review covers the computational aspects of identifying small molecules, from the identification of a compound searching a reference spectral library, to the structural elucidation of unknowns. In detail, we describe the basic principles and pitfalls of searching mass spectral reference libraries. Determining the molecular formula of the compound can serve as a basis for subsequent structural elucidation; consequently, we cover different methods for molecular formula identification, focussing on isotope pattern analysis. We then discuss automated methods to deal with mass spectra of compounds that are not present in spectral libraries, and provide an insight into de novo analysis of fragmentation spectra using fragmentation trees. In addition, this review shortly covers the reconstruction of metabolic networks using MS data. Finally, we list available software for different steps of the analysis pipeline. PMID:23453222

Diversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interaction

NASA Astrophysics Data System (ADS)

Kim, Jonghoon; Jung, Jinjoo; Koo, Jaeyoung; Cho, Wansang; Lee, Won Seok; Kim, Chanwoo; Park, Wonwoo; Park, Seung Bum

2016-10-01

Diversity-oriented synthesis (DOS) can provide a collection of diverse and complex drug-like small molecules, which is critical in the development of new chemical probes for biological research of undruggable targets. However, the design and synthesis of small-molecule libraries with improved biological relevance as well as maximized molecular diversity represent a key challenge. Herein, we employ functional group-pairing strategy for the DOS of a chemical library containing privileged substructures, pyrimidodiazepine or pyrimidine moieties, as chemical navigators towards unexplored bioactive chemical space. To validate the utility of this DOS library, we identify a new small-molecule inhibitor of leucyl-tRNA synthetase-RagD protein-protein interaction, which regulates the amino acid-dependent activation of mechanistic target of rapamycin complex 1 signalling pathway. This work highlights that privileged substructure-based DOS strategy can be a powerful research tool for the construction of drug-like compounds to address challenging biological targets.

Being there: the library as place.

PubMed

Weise, Frieda

2004-01-01

The value of the library as place is examined in this Janet Doe Lecture. The lecture, which is intended to focus on the history or philosophy of health sciences librarianship, presents an overview of the library as a place in society from ancient times to the present. The impact of information technology and changes in the methods of scholarly publication from print to digital are addressed as well as the role of the library as the repository of the written historical record of cultures. Functions and services of libraries are discussed in light of the physical library facility of the future. Finally, librarians are asked to remember the enduring values of librarianship in planning libraries of the future.

Being there: the library as place*

PubMed Central

Weise, Frieda

2004-01-01

The value of the library as place is examined in this Janet Doe Lecture. The lecture, which is intended to focus on the history or philosophy of health sciences librarianship, presents an overview of the library as a place in society from ancient times to the present. The impact of information technology and changes in the methods of scholarly publication from print to digital are addressed as well as the role of the library as the repository of the written historical record of cultures. Functions and services of libraries are discussed in light of the physical library facility of the future. Finally, librarians are asked to remember the enduring values of librarianship in planning libraries of the future. PMID:14762459

Instructional Trends from AASL Journals: 1972-2007--Part 2: From Library-Focused to Information-Focused

ERIC Educational Resources Information Center

Callison, Daniel

2009-01-01

This is Part 2 of a three-part summary of selected articles from the journals of the American Association of School Librarians (AASL) over a period of thirty-five years from 1972 to 2007. This three-part series in the April, May, and June (2009) issues of "School Library Media Activities Monthly" ("SLMAM") will illustrate the evolution in…

No Natives Here: A Focus Group Study of Student Perceptions of Web 2.0 and the Academic Library

ERIC Educational Resources Information Center

Burhanna, Kenneth J.; Seeholzer, Jamie

2009-01-01

This study explores Web 2.0 technologies in an academic library through focus groups with undergraduates at Kent State University. Results reveal that students, despite being heavy users, are less sophisticated and expressive in their use of Web 2.0 than presumed. Students set clear boundaries between educational and social spaces on the Web, and…

Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation.

PubMed

Xu, Yang; Lu, Hong; Kennedy, Jack P; Yan, Xuxia; McAllister, Laura A; Yamamoto, Noboru; Moss, Jason A; Boldt, Grant E; Jiang, Shibo; Janda, Kim D

2006-01-01

Protein-protein interactions are of critical importance in biological systems, and small molecule modulators of such protein recognition and intervention processes are of particular interest. To investigate this area of research, we have synthesized small-molecule libraries that can disrupt a number of biologically relevant protein-protein interactions. These library members are designed upon planar motif, appended with a variety of chemical functions, which we have termed "credit-card" structures. From two of our "credit-card" libraries, a series of molecules were uncovered which act as inhibitors against the HIV-1 gp41 fusogenic 6-helix bundle core formation, viral antigen p24 formation, and cell-cell fusion at low micromolar concentrations. From the high-throughput screening assays we utilized, a selective index (SI) value of 4.2 was uncovered for compound 2261, which bodes well for future structure activity investigations and the design of more potent gp41 inhibitors.

Countdown to a New Library: A Blueprint for Success.

ERIC Educational Resources Information Center

Woodward, Jeannette

1999-01-01

Focuses on selecting appropriate furnishings, floorings, and surfaces for a new library. Discusses appropriate color schemes; carpeting; protecting wood surfaces with polyurethane, user-friendly furniture, and flexible staff workstations. (AEF)

Peer education in the commons: a new approach to reference services.

PubMed

Neal, Ruth E; Ajamie, Lauren F; Harmon, Karen D; Kellerby, Carissa D; Schweikhard, April J

2010-10-01

In planning for a new library construction project for the University of Oklahoma-Tulsa, graduate students enrolled in the University of Oklahoma (OU) School of Library and Information Studies collaborated in an innovative effort to develop a commons-based reference service. By first considering a philosophical approach to the need for a commons, blending in the experiences of other libraries that have created similar spaces, and focusing on the workflow issues likely to be encountered by the graduate assistants staffing the commons itself, this planning team developed an uncommon peer-to-peer approach to reference and education services, one focused on the patron as student.

What's Your Story?: Dutch Library DOK's New Cutting-Edge Community Tech Projects

ERIC Educational Resources Information Center

Boekesteijn, Erik

2010-01-01

DOK, the cutting-edge library center in Delft, the Netherlands, has been finding new ways to elaborate on the social networking impulse. A good library unites people from all levels of society, and DOK's unique innovation department focuses specifically on how media can bring people together. It's doing so using technology to inspire and connect…

Working Connections: Suzan Lee--UBS Securities LLC, New York

ERIC Educational Resources Information Center

Library Journal, 2004

2004-01-01

This article is about Suzan Lee of UBS Securities LLC in New York, a person who is dedicated to connecting aspiring professionals to opportunities in the world of special libraries. In 1999, Lee realized that most library students had only one resource for internships--their library schools--and that these offerings focused largely on public and…

Financing Rural Library Services: A Comparative Analysis.

ERIC Educational Resources Information Center

Weatherby, James B.; And Others

This paper focuses on the identification and implementation of an adequate and appropriate funding mechanism or mechanisms for the funding of rural library services in Idaho. It is noted that the data for the report were taken primarily from the U.S. Bureau of the Census, with additional data from a 1990 survey of state library officials. The…

Rhythm and Books: Feel the Beat! 1996 Florida Library Youth Program.

ERIC Educational Resources Information Center

Rupert, Libby, Comp.; And Others

The Florida Library Youth Program is an extension of the Florida Summer Library Program and has emerged in response to a need to provide programs for school-age children at times other than the traditional summer vacation. The theme, "Rhythm and Books--Feel the Beat!," focuses on music and rhythms that abound around children in the…

Congress, Laws, and Regulations: Government Documents. Academic Library Guide. Government Documents Series Number 2.

ERIC Educational Resources Information Center

Amen, Kathleen L.

This document is the second in a series of four guides to the government documents collection in the academic library at St. Mary's University (San Antonio, Texas); the library has been a selective depository for U.S. Government publications since 1964. Focusing on congressional publications pertaining to laws and regulations, this guide describes…

The Information Needs of Virtual Users: A Study of Second Life Libraries

ERIC Educational Resources Information Center

Chow, Anthony S.; Baity, C. Chase; Zamarripa, Marilyn; Chappell, Pam; Rachlin, David; Vinson, Curtis

2012-01-01

As virtual worlds continue to proliferate globally, libraries are faced with the question of whether to provide information services to virtual patrons. This study, utilizing a mixed-method approach of interviews, focus groups, and surveys, represents one of the largest studies of virtual libraries attempted to date. Taking a holistic perspective,…

Improving Library Service Quality to Graduate Students: LibQual+[TM] Survey Results in a Practical Setting

ERIC Educational Resources Information Center

Jankowska, Maria Anna; Hertel, Karen; Young, Nancy J.

2006-01-01

The LibQUAL+[TM] survey was conducted to determine user satisfaction and expectations concerning library service quality. The results of the "22 items and a box" constituted a rich source of information for the University of Idaho (UI) Library's strategic planning process. Focusing on graduate students, this study used three…

The Internet Initiative: Libraries Providing Internet Services and How They Plan, Pay, and Manage.

ERIC Educational Resources Information Center

Valauskas, Edward J., Ed.; John, Nancy R., Ed.

This book examines real-life projects involving Internet access, use, and financing in libraries. It focuses on how becoming an Internet provider has improved many libraries' public visibility, level of service, and communication with other educational or community institutions. Chapters include: (1) "Setting Up an Internet Users Group in the…

Fast Facts: Recent Statistics from the Library Research Service, Nos. 214-224. February 11-March 31, 2005

ERIC Educational Resources Information Center

Steffen, Nicolle Olivia; Lance, Keith Curry; Lietzau, Zeth; Dickenson, Don

2005-01-01

Eleven issues of "Fast Facts" from the Library Research Service cover information from libraries across Colorado. These issues focus on topics from the public, academic, and school sectors. These topics include patron use of AskColorado (a statewide virtual reference service) and the rising use of online services. The "Fast…

The Determinants of Organizational Innovation: An Interpretation and Implications for Research Libraries

ERIC Educational Resources Information Center

Jantz, Ronald C.

2015-01-01

The research reported here is focused on a specific type of change in an organization: an innovation. In an empirical analysis of research libraries, it was found that five factors had a significant impact on the innovation performance of the library. These factors relate to the strategy, organizational structure, and leadership of the research…

Procedure to Generate the MPACT Multigroup Library

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Kang Seog

The CASL neutronics simulator MPACT is under development for the neutronics and T-H coupled simulation for the light water reactor. The objective of this document is focused on reviewing the current procedure to generate the MPACT multigroup library. Detailed methodologies and procedures are included in this document for further discussion to improve the MPACT multigroup library.

Providing Staff Training and Programming to Support People with Disabilities: An Academic Library Case Study

ERIC Educational Resources Information Center

Brannen, Michelle H.; Milewski, Steven; Mack, Thura

2017-01-01

This case study explores services academic libraries provide to students with disabilities and the impact these can have on the success and experience of these students. The study focuses on staff training and outreach programming. The authors examine the academic library literature surrounding these topics, provide examples of programming…

Preparation and Presentation of the Library Budget. SPEC Kit 32.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit on the preparation and presentation of the library budget in Association of Research Libraries (ARL) institutions contains a concise summary of the results of a 1977 member survey on budget preparation and eight related primary source documents. The summary of the Systems and Procedures Exchange Center (SPEC) survey focuses on types of…

Expanding beyond Our Library Walls: Building an Active Online Community through Facebook

ERIC Educational Resources Information Center

Ganster, Ligaya; Schumacher, Bridget

2009-01-01

This article demonstrates how Facebook, a popular social networking Web site, provides libraries with the opportunity to develop an outreach presence and information portal within an online community. While much of the recent literature examines Facebook and defines its potential use within libraries, this article focuses on the use of Facebook's…

Como ayudar a sus hijos a usar la biblioteca (Helping Your Child Use the Library).

ERIC Educational Resources Information Center

Perkinson, Kathryn

Focusing on the cooperative role of parents and public libraries in stimulating reading interests in children of all ages, this booklet addresses the following issues: (1) getting children interested in reading (reading aloud to children; encouraging children to read to you; starting a home library; showing children that you enjoy reading;…

Buyers and Borrowers: The Application of Consumer Theory to the Study of Library Use.

ERIC Educational Resources Information Center

Emery, Charles D.

Using Ehrenberg's application of mathematical models to the analysis and prediction of repeated buying patterns of consumers, this study focuses on the concept of library use as a form of consumer behavior. The following hypotheses were tested: designated library user groups will tend to exhibit stable behavioral patterns with respect to the…

High Density Data Storage, the SONY Data DiscMan Electronic Book, and the Unfolding Multi-Media Revolution.

ERIC Educational Resources Information Center

Kountz, John

1991-01-01

Description of high density data storage (HDDS) devices focuses on CD-ROMs and explores their impact on libraries, publishing, education, and library communications. Highlights include costs; technical standards; reading devices; authoring systems; robotics; the influence of new technology on the role of libraries; and royalty and copyright issues…

Strategic Alignment at the University of Manchester Library: Ambitions, Transitions, and New Values

ERIC Educational Resources Information Center

Jeal, Yvette

2014-01-01

The University of Manchester Library (UML) is embarking on an ambitious new strategy that aims to align the library more closely to the work of the University--to contribute to the University's strategic success. This article describes elements of the strategy development and content, focusing on methods used; how the service has worked…

Symbolic Interactionism and Library Research: Using a Qualitative Methodology To Understand Library Interchange.

ERIC Educational Resources Information Center

Fidishun, Dolores

2002-01-01

Explains symbolic interactionism as a theory for analyzing research based on a qualitative interpretive process that can help librarians to understand the way in which the library staff and users view services, training, policy, and other issues. The theory focuses on the symbolic meaning of objects, such as books, and events as they are…

Learning Spaces in Academic Libraries--A Review of the Evolving Trends

ERIC Educational Resources Information Center

Turner, Arlee; Welch, Bernadette; Reynolds, Sue

2013-01-01

This paper presents a review of the professional discourse regarding the evolution of information and learning spaces in academic libraries, particularly in the first decade of the twenty-first century. It investigates the evolution of academic libraries and the development of learning spaces focusing on the use of the terms which have evolved…

The Roles That Librarians and Libraries Play in Distance Education Settings

ERIC Educational Resources Information Center

Corbett, Amanda; Brown, Abbie

2015-01-01

This article explores the literature that focuses on the various roles librarians and libraries play in distance education settings. Learners visit libraries either in person or via networked computing technology to ask for help with their online courses. Questions range from how to upload a document with a learning management system, to how to…

New Catalog, Same Old User. Recommendations for Teaching the Online Catalog.

ERIC Educational Resources Information Center

Fahey, Barbara J.; Campbell, Douglas G.

This study focuses on the planning necessary to support library instruction for an online public access catalog in an academic library. The installation of an online catalog is viewed as an opportunity for librarians to teach effective use of the library catalog. The project report consists of a review of the literature pertaining to the…

Unifying Space and Service for Makers, Entrepreneurs, and Digital Scholars

ERIC Educational Resources Information Center

Nichols, Jennifer; Melo, Marijel; Dewland, Jason

2017-01-01

This article explores the evolution and role of makerspaces in academic libraries, with a particular focus on how libraries are using innovation spaces in support of entrepreneurship and digital humanities on campus. At the University of Arizona Libraries in Tucson, a unique new coworking and makerspace called the iSpace has developed. While many…

Adult Library Programs and Resources for Women.

ERIC Educational Resources Information Center

Cannistra, Cheryl

1979-01-01

Cites topics, videotapes, and films focusing on women's issues appropriate for public library adult programs, and presents annotated bibliographies of materials on the legal rights of women, battered women, and psychological depression. (CWM)

Reading in the Clouds: Building a Library at a School in India.

ERIC Educational Resources Information Center

Khalsa, Gurupreet K.

2000-01-01

Describes how, over three years, teachers, students, parents, and administrators of a girls' school in India built a school library, going from a small locked-up collection with no check-out system to a warm and busy library room that was a popular hub of activity at the school, with a dynamic and expanding collection and a full-time librarian.…