Commissioning of a new SeHCAT detector and comparison with an uncollimated gamma camera.

PubMed

Taylor, Jonathan C; Hillel, Philip G; Himsworth, John M

2014-10-01

Measurements of SeHCAT (tauroselcholic [75selenium] acid) retention have been used to diagnose bile acid malabsorption for a number of years. In current UK practice the vast majority of centres calculate uptake using an uncollimated gamma camera. Because of ever-increasing demands on gamma camera time, a new 'probe' detector was designed, assembled and commissioned. To validate the system, nine patients were scanned at day 0 and day 7 with both the new probe detector and an uncollimated gamma camera. Commissioning results were largely in line with expectations. Spatial resolution (full-width 95% of maximum) at 1 m was 36.6 cm, the background count rate was 24.7 cps and sensitivity at 1 m was 720.8 cps/MBq. The patient comparison study showed a mean absolute difference in retention measurements of 0.8% between the probe and uncollimated gamma camera, and SD of ± 1.8%. The study demonstrated that it is possible to create a simple, reproducible SeHCAT measurement system using a commercially available scintillation detector. Retention results from the probe closely agreed with those from the uncollimated gamma camera.

Development of a high sensitivity pinhole type gamma camera using semiconductors for low dose rate fields

NASA Astrophysics Data System (ADS)

Ueno, Yuichiro; Takahashi, Isao; Ishitsu, Takafumi; Tadokoro, Takahiro; Okada, Koichi; Nagumo, Yasushi; Fujishima, Yasutake; Yoshida, Akira; Umegaki, Kikuo

2018-06-01

We developed a pinhole type gamma camera, using a compact detector module of a pixelated CdTe semiconductor, which has suitable sensitivity and quantitative accuracy for low dose rate fields. In order to improve the sensitivity of the pinhole type semiconductor gamma camera, we adopted three methods: a signal processing method to set the discriminating level lower, a high sensitivity pinhole collimator and a smoothing image filter that improves the efficiency of the source identification. We tested basic performances of the developed gamma camera and carefully examined effects of the three methods. From the sensitivity test, we found that the effective sensitivity was about 21 times higher than that of the gamma camera for high dose rate fields which we had previously developed. We confirmed that the gamma camera had sufficient sensitivity and high quantitative accuracy; for example, a weak hot spot (0.9 μSv/h) around a tree root could be detected within 45 min in a low dose rate field test, and errors of measured dose rates with point sources were less than 7% in a dose rate accuracy test.

Electron-tracking Compton gamma-ray camera for small animal and phantom imaging

NASA Astrophysics Data System (ADS)

Kabuki, Shigeto; Kimura, Hiroyuki; Amano, Hiroo; Nakamoto, Yuji; Kubo, Hidetoshi; Miuchi, Kentaro; Kurosawa, Shunsuke; Takahashi, Michiaki; Kawashima, Hidekazu; Ueda, Masashi; Okada, Tomohisa; Kubo, Atsushi; Kunieda, Etuso; Nakahara, Tadaki; Kohara, Ryota; Miyazaki, Osamu; Nakazawa, Tetsuo; Shirahata, Takashi; Yamamoto, Etsuji; Ogawa, Koichi; Togashi, Kaori; Saji, Hideo; Tanimori, Toru

2010-11-01

We have developed an electron-tracking Compton camera (ETCC) for medical use. Our ETCC has a wide energy dynamic range (200-1300 keV) and wide field of view (3 sr), and thus has potential for advanced medical use. To evaluate the ETCC, we imaged the head (brain) and bladder of mice that had been administered with F-18-FDG. We also imaged the head and thyroid gland of mice using double tracers of F-18-FDG and I-131 ions.

The HURRA filter: An easy method to eliminate collimator artifacts in high-energy gamma camera images.

PubMed

Perez-Garcia, H; Barquero, R

The correct determination and delineation of tumor/organ size is crucial in 2-D imaging in 131 I therapy. These images are usually obtained using a system composed of a Gamma camera and high-energy collimator, although the system can produce artifacts in the image. This article analyses these artifacts and describes a correction filter that can eliminate those collimator artifacts. Using free software, ImageJ, a central profile in the image is obtained and analyzed. Two components can be seen in the fluctuation of the profile: one associated with the stochastic nature of the radiation, plus electronic noise and the other periodically across the position in space due to the collimator. These frequencies are analytically obtained and compared with the frequencies in the Fourier transform of the profile. A specially developed filter removes the artifacts in the 2D Fourier transform of the DICOM image. This filter is tested using a 15-cm-diameter Petri dish with 131 I radioactive water (big object size) image, a 131 I clinical pill (small object size) image, and an image of the remainder of the lesion of two patients treated with 3.7GBq (100mCi), and 4.44GBq (120mCi) of 131 I, respectively, after thyroidectomy. The artifact is due to the hexagonal periodic structure of the collimator. The use of the filter on large-sized images reduces the fluctuation by 5.8-3.5%. In small-sized images, the FWHM can be determined in the filtered image, while this is impossible in the unfiltered image. The definition of tumor boundary and the visualization of the activity distribution inside patient lesions improve drastically when the filter is applied to the corresponding images obtained with HE gamma camera. The HURRA filter removes the artifact of high-energy collimator artifacts in planar images obtained with a Gamma camera without reducing the image resolution. It can be applied in any study of patient quantification because the number of counts remains invariant. The filter makes possible the definition and delimitation of small uptakes, such as those presented in treatments with 131 I. Copyright © 2016 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

Flexible nuclear medicine camera and method of using

DOEpatents

Dilmanian, F.A.; Packer, S.; Slatkin, D.N.

1996-12-10

A nuclear medicine camera and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera includes a flexible frame containing a window, a photographic film, and a scintillation screen, with or without a gamma-ray collimator. The frame flexes for following the contour of the examination site on the patient, with the window being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film and the radiation source inside the patient. The frame is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms. 11 figs.

Development of an all-in-one gamma camera/CCD system for safeguard verification

NASA Astrophysics Data System (ADS)

Kim, Hyun-Il; An, Su Jung; Chung, Yong Hyun; Kwak, Sung-Woo

2014-12-01

For the purpose of monitoring and verifying efforts at safeguarding radioactive materials in various fields, a new all-in-one gamma camera/charged coupled device (CCD) system was developed. This combined system consists of a gamma camera, which gathers energy and position information on gamma-ray sources, and a CCD camera, which identifies the specific location in a monitored area. Therefore, 2-D image information and quantitative information regarding gamma-ray sources can be obtained using fused images. A gamma camera consists of a diverging collimator, a 22 × 22 array CsI(Na) pixelated scintillation crystal with a pixel size of 2 × 2 × 6 mm3 and Hamamatsu H8500 position-sensitive photomultiplier tube (PSPMT). The Basler scA640-70gc CCD camera, which delivers 70 frames per second at video graphics array (VGA) resolution, was employed. Performance testing was performed using a Co-57 point source 30 cm from the detector. The measured spatial resolution and sensitivity were 4.77 mm full width at half maximum (FWHM) and 7.78 cps/MBq, respectively. The energy resolution was 18% at 122 keV. These results demonstrate that the combined system has considerable potential for radiation monitoring.

Color reproduction software for a digital still camera

NASA Astrophysics Data System (ADS)

Lee, Bong S.; Park, Du-Sik; Nam, Byung D.

1998-04-01

We have developed a color reproduction software for a digital still camera. The image taken by the camera was colorimetrically reproduced on the monitor after characterizing the camera and the monitor, and color matching between two devices. The reproduction was performed at three levels; level processing, gamma correction, and color transformation. The image contrast was increased after the level processing adjusting the level of dark and bright portions of the image. The relationship between the level processed digital values and the measured luminance values of test gray samples was calculated, and the gamma of the camera was obtained. The method for getting the unknown monitor gamma was proposed. As a result, the level processed values were adjusted by the look-up table created by the camera and the monitor gamma correction. For a color transformation matrix for the camera, 3 by 3 or 3 by 4 matrix was used, which was calculated by the regression between the gamma corrected values and the measured tristimulus values of each test color samples the various reproduced images were displayed on the dialogue box implemented in our software, which were generated according to four illuminations for the camera and three color temperatures for the monitor. An user can easily choose he best reproduced image comparing each others.

Study of the polarimetric performance of a Si/CdTe semiconductor Compton camera for the Hitomi satellite

NASA Astrophysics Data System (ADS)

Katsuta, Junichiro; Edahiro, Ikumi; Watanabe, Shin; Odaka, Hirokazu; Uchida, Yusuke; Uchida, Nagomi; Mizuno, Tsunefumi; Fukazawa, Yasushi; Hayashi, Katsuhiro; Habata, Sho; Ichinohe, Yuto; Kitaguchi, Takao; Ohno, Masanori; Ohta, Masayuki; Takahashi, Hiromitsu; Takahashi, Tadayuki; Takeda, Shin'ichiro; Tajima, Hiroyasu; Yuasa, Takayuki; Itou, Masayoshi; SGD Team

2016-12-01

Gamma-ray polarization offers a unique probe into the geometry of the γ-ray emission process in celestial objects. The Soft Gamma-ray Detector (SGD) onboard the X-ray observatory Hitomi is a Si/CdTe Compton camera and is expected to be an excellent polarimeter, as well as a highly sensitive spectrometer due to its good angular coverage and resolution for Compton scattering. A beam test of the final-prototype for the SGD Compton camera was conducted to demonstrate its polarimetric capability and to verify and calibrate the Monte Carlo simulation of the instrument. The modulation factor of the SGD prototype camera, evaluated for the inner and outer parts of the CdTe sensors as absorbers, was measured to be 0.649-0.701 (inner part) and 0.637-0.653 (outer part) at 122.2 keV and 0.610-0.651 (inner part) and 0.564-0.592 (outer part) at 194.5 keV at varying polarization angles with respect to the detector. This indicates that the relative systematic uncertainty of the modulation factor is as small as ∼ 3 % .

Online gamma-camera imaging of 103Pd seeds (OGIPS) for permanent breast seed implantation

NASA Astrophysics Data System (ADS)

Ravi, Ananth; Caldwell, Curtis B.; Keller, Brian M.; Reznik, Alla; Pignol, Jean-Philippe

2007-09-01

Permanent brachytherapy seed implantation is being investigated as a mode of accelerated partial breast irradiation for early stage breast cancer patients. Currently, the seeds are poorly visualized during the procedure making it difficult to perform a real-time correction of the implantation if required. The objective was to determine if a customized gamma-camera can accurately localize the seeds during implantation. Monte Carlo simulations of a CZT based gamma-camera were used to assess whether images of suitable quality could be derived by detecting the 21 keV photons emitted from 74 MBq 103Pd brachytherapy seeds. A hexagonal parallel hole collimator with a hole length of 38 mm, hole diameter of 1.2 mm and 0.2 mm septa, was modeled. The design of the gamma-camera was evaluated on a realistic model of the breast and three layers of the seed distribution (55 seeds) based on a pre-implantation CT treatment plan. The Monte Carlo simulations showed that the gamma-camera was able to localize the seeds with a maximum error of 2.0 mm, using only two views and 20 s of imaging. A gamma-camera can potentially be used as an intra-procedural image guidance system for quality assurance for permanent breast seed implantation.

Flexible nuclear medicine camera and method of using

DOEpatents

Dilmanian, F. Avraham; Packer, Samuel; Slatkin, Daniel N.

1996-12-10

A nuclear medicine camera 10 and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera 10 includes a flexible frame 20 containing a window 22, a photographic film 24, and a scintillation screen 26, with or without a gamma-ray collimator 34. The frame 20 flexes for following the contour of the examination site on the patient, with the window 22 being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film 24 and the radiation source inside the patient. The frame 20 is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame 20 for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms.

Optimal configuration of a low-dose breast-specific gamma camera based on semiconductor CdZnTe pixelated detectors

NASA Astrophysics Data System (ADS)

Genocchi, B.; Pickford Scienti, O.; Darambara, DG

2017-05-01

Breast cancer is one of the most frequent tumours in women. During the ‘90s, the introduction of screening programmes allowed the detection of cancer before the palpable stage, reducing its mortality up to 50%. About 50% of the women aged between 30 and 50 years present dense breast parenchyma. This percentage decreases to 30% for women between 50 to 80 years. In these women, mammography has a sensitivity of around 30%, and small tumours are covered by the dense parenchyma and missed in the mammogram. Interestingly, breast-specific gamma-cameras based on semiconductor CdZnTe detectors have shown to be of great interest to early diagnosis. Infact, due to the high energy, spatial resolution, and high sensitivity of CdZnTe, molecular breast imaging has been shown to have a sensitivity of about 90% independently of the breast parenchyma. The aim of this work is to determine the optimal combination of the detector pixel size, hole shape, and collimator material in a low dose dual head breast specific gamma camera based on a CdZnTe pixelated detector at 140 keV, in order to achieve high count rate, and the best possible image spatial resolution. The optimal combination has been studied by modeling the system using the Monte Carlo code GATE. Six different pixel sizes from 0.85 mm to 1.6 mm, two hole shapes, hexagonal and square, and two different collimator materials, lead and tungsten were considered. It was demonstrated that the camera achieved higher count rates, and better signal-to-noise ratio when equipped with square hole, and large pixels (> 1.3 mm). In these configurations, the spatial resolution was worse than using small pixel sizes (< 1.3 mm), but remained under 3.6 mm in all cases.

Characterization and commissioning of the SST-1M camera for the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Aguilar, J. A.; Bilnik, W.; Błocki, J.; Bogacz, L.; Borkowski, J.; Bulik, T.; Cadoux, F.; Christov, A.; Curyło, M.; della Volpe, D.; Dyrda, M.; Favre, Y.; Frankowski, A.; Grudnik, Ł.; Grudzińska, M.; Heller, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandat, D.; Marszałek, A.; Medina Miranda, L. D.; Michałowski, J.; Moderski, R.; Montaruli, T.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Paśko, P.; Pech, M.; Porcelli, A.; Prandini, E.; Rajda, P.; Rameez, M.; Schioppa, E., Jr.; Schovanek, P.; Seweryn, K.; Skowron, K.; Sliusar, V.; Sowiński, M.; Stawarz, Ł.; Stodulska, M.; Stodulski, M.; Toscano, S.; Troyano Pujadas, I.; Walter, R.; Wiȩcek, M.; Zagdański, A.; Ziȩtara, K.; Żychowski, P.

2017-02-01

The Cherenkov Telescope Array (CTA), the next generation very high energy gamma-rays observatory, will consist of three types of telescopes: large (LST), medium (MST) and small (SST) size telescopes. The SSTs are dedicated to the observation of gamma-rays with energy between a few TeV and a few hundreds of TeV. The SST array is expected to have 70 telescopes of different designs. The single-mirror small size telescope (SST-1 M) is one of the proposed telescope designs under consideration for the SST array. It will be equipped with a 4 m diameter segmented mirror dish and with an innovative camera based on silicon photomultipliers (SiPMs). The challenge is not only to build a telescope with exceptional performance but to do it foreseeing its mass production. To address both of these challenges, the camera adopts innovative solutions both for the optical system and readout. The Photo-Detection Plane (PDP) of the camera is composed of 1296 pixels, each made of a hollow, hexagonal light guide coupled to a hexagonal SiPM designed by the University of Geneva and Hamamatsu. As no commercial ASIC would satisfy the CTA requirements when coupled to such a large sensor, dedicated preamplifier electronics have been designed. The readout electronics also use an innovative approach in gamma-ray astronomy by adopting a fully digital approach. All signals coming from the PDP are digitized in a 250 MHz Fast ADC and stored in ring buffers waiting for a trigger decision to send them to the pre-processing server where calibration and higher level triggers will decide whether the data are stored. The latest generation of FPGAs is used to achieve high data rates and also to exploit all the flexibility of the system. As an example each event can be flagged according to its trigger pattern. All of these features have been demonstrated in laboratory measurements on realistic elements and the results of these measurements will be presented in this contribution.

An evolution of technologies and applications of gamma imagers in the nuclear cycle industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khalil, R. A.; Carrel, F.; Menaa, N.

The tracking of radiation contamination and distribution has become a high priority in the nuclear cycle industry in order to respect the ALARA principle which is a main challenge during decontamination and dismantling activities. To support this need, AREVA/CANBERRA and CEA LIST have been actively carrying out research and development on a gamma-radiation imager. In this paper we will present the new generation of gamma camera, called GAMPIX. This system is based on the Timepix chip, hybridized with a CdTe substrate. A coded mask could be used in order to increase the sensitivity of the camera. Moreover, due to themore » USB connection with a standard computer, this gamma camera is immediately operational and user-friendly. The final system is a very compact gamma camera (global weight is less than 1 kg without any shielding) which could be used as a hand-held device for radioprotection purposes. In this article, we present the main characteristics of this new generation of gamma camera and we expose experimental results obtained during in situ measurements. Even though we present preliminary results the final product is under industrialization phase to address various applications specifications. (authors)« less

Development of gamma-photon/Cerenkov-light hybrid system for simultaneous imaging of I-131 radionuclide

NASA Astrophysics Data System (ADS)

Yamamoto, Seiichi; Suzuki, Mayumi; Kato, Katsuhiko; Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu; Ogata, Yoshimune; Hatazawa, Jun

2016-09-01

Although iodine 131 (I-131) is used for radionuclide therapy, high resolution images are difficult to obtain with conventional gamma cameras because of the high energy of I-131 gamma photons (364 keV). Cerenkov-light imaging is a possible method for beta emitting radionuclides, and I-131 (606 MeV maximum beta energy) is a candidate to obtain high resolution images. We developed a high energy gamma camera system for I-131 radionuclide and combined it with a Cerenkov-light imaging system to form a gamma-photon/Cerenkov-light hybrid imaging system to compare the simultaneously measured images of these two modalities. The high energy gamma imaging detector used 0.85-mm×0.85-mm×10-mm thick GAGG scintillator pixels arranged in a 44×44 matrix with a 0.1-mm thick reflector and optical coupled to a Hamamatsu 2 in. square position sensitive photomultiplier tube (PSPMT: H12700 MOD). The gamma imaging detector was encased in a 2 cm thick tungsten shield, and a pinhole collimator was mounted on its top to form a gamma camera system. The Cerenkov-light imaging system was made of a high sensitivity cooled CCD camera. The Cerenkov-light imaging system was combined with the gamma camera using optical mirrors to image the same area of the subject. With this configuration, we simultaneously imaged the gamma photons and the Cerenkov-light from I-131 in the subjects. The spatial resolution and sensitivity of the gamma camera system for I-131 were respectively 3 mm FWHM and 10 cps/MBq for the high sensitivity collimator at 10 cm from the collimator surface. The spatial resolution of the Cerenkov-light imaging system was 0.64 mm FWHM at 10 cm from the system surface. Thyroid phantom and rat images were successfully obtained with the developed gamma-photon/Cerenkov-light hybrid imaging system, allowing direct comparison of these two modalities. Our developed gamma-photon/Cerenkov-light hybrid imaging system will be useful to evaluate the advantages and disadvantages of these two modalities.

Gate simulation of Compton Ar-Xe gamma-camera for radionuclide imaging in nuclear medicine

NASA Astrophysics Data System (ADS)

Dubov, L. Yu; Belyaev, V. N.; Berdnikova, A. K.; Bolozdynia, A. I.; Akmalova, Yu A.; Shtotsky, Yu V.

2017-01-01

Computer simulations of cylindrical Compton Ar-Xe gamma camera are described in the current report. Detection efficiency of cylindrical Ar-Xe Compton camera with internal diameter of 40 cm is estimated as1-3%that is 10-100 times higher than collimated Anger’s camera. It is shown that cylindrical Compton camera can image Tc-99m radiotracer distribution with uniform spatial resolution of 20 mm through the whole field of view.

Design criteria for a high energy Compton Camera and possible application to targeted cancer therapy

NASA Astrophysics Data System (ADS)

Conka Nurdan, T.; Nurdan, K.; Brill, A. B.; Walenta, A. H.

2015-07-01

The proposed research focuses on the design criteria for a Compton Camera with high spatial resolution and sensitivity, operating at high gamma energies and its possible application for molecular imaging. This application is mainly on the detection and visualization of the pharmacokinetics of tumor targeting substances specific for particular cancer sites. Expected high resolution (< 0.5 mm) permits monitoring the pharmacokinetics of labeled gene constructs in vivo in small animals with a human tumor xenograft which is one of the first steps in evaluating the potential utility of a candidate gene. The additional benefit of high sensitivity detection will be improved cancer treatment strategies in patients based on the use of specific molecules binding to cancer sites for early detection of tumors and identifying metastasis, monitoring drug delivery and radionuclide therapy for optimum cell killing at the tumor site. This new technology can provide high resolution, high sensitivity imaging of a wide range of gamma energies and will significantly extend the range of radiotracers that can be investigated and used clinically. The small and compact construction of the proposed camera system allows flexible application which will be particularly useful for monitoring residual tumor around the resection site during surgery. It is also envisaged as able to test the performance of new drug/gene-based therapies in vitro and in vivo for tumor targeting efficacy using automatic large scale screening methods.

Microchannel plate streak camera

DOEpatents

Wang, Ching L.

1989-01-01

An improved streak camera in which a microchannel plate electron multiplier is used in place of or in combination with the photocathode used in prior streak cameras. The improved streak camera is far more sensitive to photons (UV to gamma-rays) than the conventional x-ray streak camera which uses a photocathode. The improved streak camera offers gamma-ray detection with high temporal resolution. It also offers low-energy x-ray detection without attenuation inside the cathode. Using the microchannel plate in the improved camera has resulted in a time resolution of about 150 ps, and has provided a sensitivity sufficient for 1000 KeV x-rays.

Potential of SeHCAT retention as an indicator of terminal ileal involvement in inflammatory bowel disease.

PubMed

Holdstock, G; Phillips, G; Hames, T K; Condon, B R; Fleming, J S; Smith, C L; Ackery, D M

1985-01-01

The absorption of 75Se-23-selena-25-homotaurocholate (SeHCAT) was compared with vitamin-B12 absorption and conventional radiography in 44 patients with inflammatory bowel disease. The retention of SeHCAT was normal in 11 patients with ulcerative colitis but was abnormally low in 9 patients with terminal-ileal resection, 9 out of 14 patients with small-bowel Crohn's disease and in 2 out of 10 patients with Crohn's colitis. The 5 patients with small-bowel Crohn's disease and normal retention had either inactive disease or no radiological evidence of terminal ileal involvement. Measurements of the absorption of vitamin B12 did not discriminate between these groups, and there was very poor correlation between B12 and SeHCAT absorption (r = 0.506, P less than 0.05). There was extremely good correlation of SeHCAT retention measured using a wholebody counter with that measured using an uncollimated gamma camera (r = 0.96, P less than 0.001). The results suggest that SeHCAT retention may prove complementary to conventional methods of assessing small-bowel disease in patients with inflammatory bowel disease. As measurement by gamma camera is feasible, this test can be used in most departments of nuclear medicine.

Progress towards a semiconductor Compton camera for prompt gamma imaging during proton beam therapy for range and dose verification

NASA Astrophysics Data System (ADS)

Gutierrez, A.; Baker, C.; Boston, H.; Chung, S.; Judson, D. S.; Kacperek, A.; Le Crom, B.; Moss, R.; Royle, G.; Speller, R.; Boston, A. J.

2018-01-01

The main objective of this work is to test a new semiconductor Compton camera for prompt gamma imaging. Our device is composed of three active layers: a Si(Li) detector as a scatterer and two high purity Germanium detectors as absorbers of high-energy gamma rays. We performed Monte Carlo simulations using the Geant4 toolkit to characterise the expected gamma field during proton beam therapy and have made experimental measurements of the gamma spectrum with a 60 MeV passive scattering beam irradiating a phantom. In this proceeding, we describe the status of the Compton camera and present the first preliminary measurements with radioactive sources and their corresponding reconstructed images.

Advances in Gamma-Ray Imaging with Intensified Quantum-Imaging Detectors

NASA Astrophysics Data System (ADS)

Han, Ling

Nuclear medicine, an important branch of modern medical imaging, is an essential tool for both diagnosis and treatment of disease. As the fundamental element of nuclear medicine imaging, the gamma camera is able to detect gamma-ray photons emitted by radiotracers injected into a patient and form an image of the radiotracer distribution, reflecting biological functions of organs or tissues. Recently, an intensified CCD/CMOS-based quantum detector, called iQID, was developed in the Center for Gamma-Ray Imaging. Originally designed as a novel type of gamma camera, iQID demonstrated ultra-high spatial resolution (< 100 micron) and many other advantages over traditional gamma cameras. This work focuses on advancing this conceptually-proven gamma-ray imaging technology to make it ready for both preclinical and clinical applications. To start with, a Monte Carlo simulation of the key light-intensification device, i.e. the image intensifier, was developed, which revealed the dominating factor(s) that limit energy resolution performance of the iQID cameras. For preclinical imaging applications, a previously-developed iQID-based single-photon-emission computed-tomography (SPECT) system, called FastSPECT III, was fully advanced in terms of data acquisition software, system sensitivity and effective FOV by developing and adopting a new photon-counting algorithm, thicker columnar scintillation detectors, and system calibration method. Originally designed for mouse brain imaging, the system is now able to provide full-body mouse imaging with sub-350-micron spatial resolution. To further advance the iQID technology to include clinical imaging applications, a novel large-area iQID gamma camera, called LA-iQID, was developed from concept to prototype. Sub-mm system resolution in an effective FOV of 188 mm x 188 mm has been achieved. The camera architecture, system components, design and integration, data acquisition, camera calibration, and performance evaluation are presented in this work. Mounted on a castered counter-weighted clinical cart, the camera also features portable and mobile capabilities for easy handling and on-site applications at remote locations where hospital facilities are not available.

Developments in mercuric iodide gamma ray imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patt, B.E.; Beyerle, A.G.; Dolin, R.C.

A mercuric iodide gamma-ray imaging array and camera system previously described has been characterized for spatial and energy resolution. Based on this data a new camera is being developed to more fully exploit the potential of the array. Characterization results and design criterion for the new camera will be presented. 2 refs., 7 figs.

Material efficiency studies for a Compton camera designed to measure characteristic prompt gamma rays emitted during proton beam radiotherapy

PubMed Central

Robertson, Daniel; Polf, Jerimy C; Peterson, Steve W; Gillin, Michael T; Beddar, Sam

2011-01-01

Prompt gamma rays emitted from biological tissues during proton irradiation carry dosimetric and spectroscopic information that can assist with treatment verification and provide an indication of the biological response of the irradiated tissues. Compton cameras are capable of determining the origin and energy of gamma rays. However, prompt gamma monitoring during proton therapy requires new Compton camera designs that perform well at the high gamma energies produced when tissues are bombarded with therapeutic protons. In this study we optimize the materials and geometry of a three-stage Compton camera for prompt gamma detection and calculate the theoretical efficiency of such a detector. The materials evaluated in this study include germanium, bismuth germanate (BGO), NaI, xenon, silicon and lanthanum bromide (LaBr3). For each material, the dimensions of each detector stage were optimized to produce the maximum number of relevant interactions. These results were used to predict the efficiency of various multi-material cameras. The theoretical detection efficiencies of the most promising multi-material cameras were then calculated for the photons emitted from a tissue-equivalent phantom irradiated by therapeutic proton beams ranging from 50 to 250 MeV. The optimized detector stages had a lateral extent of 10 × 10 cm2 with the thickness of the initial two stages dependent on the detector material. The thickness of the third stage was fixed at 10 cm regardless of material. The most efficient single-material cameras were composed of germanium (3 cm) and BGO (2.5 cm). These cameras exhibited efficiencies of 1.15 × 10−4 and 9.58 × 10−5 per incident proton, respectively. The most efficient multi-material camera design consisted of two initial stages of germanium (3 cm) and a final stage of BGO, resulting in a theoretical efficiency of 1.26 × 10−4 per incident proton. PMID:21508442

Prompt gamma imaging of proton pencil beams at clinical dose rate

NASA Astrophysics Data System (ADS)

Perali, I.; Celani, A.; Bombelli, L.; Fiorini, C.; Camera, F.; Clementel, E.; Henrotin, S.; Janssens, G.; Prieels, D.; Roellinghoff, F.; Smeets, J.; Stichelbaut, F.; Vander Stappen, F.

2014-10-01

In this work, we present experimental results of a prompt gamma camera for real-time proton beam range verification. The detection system features a pixelated Cerium doped lutetium based scintillation crystal, coupled to Silicon PhotoMultiplier arrays, read out by dedicated electronics. The prompt gamma camera uses a knife-edge slit collimator to produce a 1D projection of the beam path in the target on the scintillation detector. We designed the detector to provide high counting statistics and high photo-detection efficiency for prompt gamma rays of several MeV. The slit design favours the counting statistics and could be advantageous in terms of simplicity, reduced cost and limited footprint. We present the description of the realized gamma camera, as well as the results of the characterization of the camera itself in terms of imaging performance. We also present the results of experiments in which a polymethyl methacrylate phantom was irradiated with proton pencil beams in a proton therapy center. A tungsten slit collimator was used and prompt gamma rays were acquired in the 3-6 MeV energy range. The acquisitions were performed with the beam operated at 100 MeV, 160 MeV and 230 MeV, with beam currents at the nozzle exit of several nA. Measured prompt gamma profiles are consistent with the simulations and we reached a precision (2σ) in shift retrieval of 4 mm with 0.5 × 108, 1.4 × 108 and 3.4 × 108 protons at 100, 160 and 230 MeV, respectively. We conclude that the acquisition of prompt gamma profiles for in vivo range verification of proton beam with the developed gamma camera and a slit collimator is feasible in clinical conditions. The compact design of the camera allows its integration in a proton therapy treatment room and further studies will be undertaken to validate the use of this detection system during treatment of real patients.

Feasibility study of a gamma camera for monitoring nuclear materials in the PRIDE facility

NASA Astrophysics Data System (ADS)

Jo, Woo Jin; Kim, Hyun-Il; An, Su Jung; Lee, Chae Young; Song, Han-Kyeol; Chung, Yong Hyun; Shin, Hee-Sung; Ahn, Seong-Kyu; Park, Se-Hwan

2014-05-01

The Korea Atomic Energy Research Institute (KAERI) has been developing pyroprocessing technology, in which actinides are recovered together with plutonium. There is no pure plutonium stream in the process, so it has an advantage of proliferation resistance. Tracking and monitoring of nuclear materials through the pyroprocess can significantly improve the transparency of the operation and safeguards. An inactive engineering-scale integrated pyroprocess facility, which is the PyRoprocess Integrated inactive DEmonstration (PRIDE) facility, was constructed to demonstrate engineering-scale processes and the integration of each unit process. the PRIDE facility may be a good test bed to investigate the feasibility of a nuclear material monitoring system. In this study, we designed a gamma camera system for nuclear material monitoring in the PRIDE facility by using a Monte Carlo simulation, and we validated the feasibility of this system. Two scenarios, according to locations of the gamma camera, were simulated using GATE (GEANT4 Application for Tomographic Emission) version 6. A prototype gamma camera with a diverging-slat collimator was developed, and the simulated and experimented results agreed well with each other. These results indicate that a gamma camera to monitor the nuclear material in the PRIDE facility can be developed.

Operating performance of the gamma-ray Cherenkov telescope: An end-to-end Schwarzschild-Couder telescope prototype for the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Dournaux, J. L.; De Franco, A.; Laporte, P.; White, R.; Greenshaw, T.; Sol, H.; Abchiche, A.; Allan, D.; Amans, J. P.; Armstrong, T. P.; Balzer, A.; Berge, D.; Boisson, C.; Bousquet, J. J.; Brown, A. M.; Bryan, M.; Buchholtz, G.; Chadwick, P. M.; Costantini, H.; Cotter, G.; Daniel, M.; De Frondat, F.; Dumas, D.; Ernenwein, J. P.; Fasola, G.; Funk, S.; Gaudemard, J.; Graham, J. A.; Gironnet, J.; Hervet, O.; Hidaka, N.; Hinton, J. A.; Huet, J. M.; Jégouzo, I.; Jogler, T.; Kawashima, T.; Kraus, M.; Lapington, J. S.; Lefaucheur, J.; Markoff, S.; Melse, T.; Morhrmann, L.; Molnyeux, P.; Nolan, S. J.; Okumura, A.; Parsons, R. D.; Ross, D.; Rowell, G.; Sato, Y.; Sayède, F.; Schmoll, J.; Schoorlemmer, H.; Servillat, M.; Stamatescu, V.; Stephan, M.; Stuik, R.; Sykes, J.; Tajima, H.; Thornhill, J.; Tibaldo, L.; Trichard, C.; Vink, J.; Watson, J.; Yamane, N.; Zech, A.; Zink, A.; CTA Consortium

2017-02-01

The Cherenkov Telescope Array (CTA) consortium aims to build the next-generation ground-based very-high-energy gamma-ray observatory. The array will feature different sizes of telescopes allowing it to cover a wide gamma-ray energy band from about 20 GeV to above 100 TeV. The highest energies, above 5 TeV, will be covered by a large number of Small-Sized Telescopes (SSTs) with a field-of-view of around 9°. The Gamma-ray Cherenkov Telescope (GCT), based on Schwarzschild-Couder dual-mirror optics, is one of the three proposed SST designs. The GCT is described in this contribution and the first images of Cherenkov showers obtained using the telescope and its camera are presented. These were obtained in November 2015 in Meudon,

The single mirror small sized telescope for the Cherenkov telescope array

NASA Astrophysics Data System (ADS)

Heller, M.; Schioppa, E., Jr.; Porcelli, A.; Pujadas, I. Troyano; Ziętara, K.; Della Volpe, D.; Montaruli, T.; Cadoux, F.; Favre, Y.; Aguilar, J. A.; Christov, A.; Prandini, E.; Rajda, P.; Rameez, M.; Bilnik, W.; Błocki, J.; Bogacz, L.; Borkowski, J.; Bulik, T.; Frankowski, A.; Grudzińska, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandat, D.; Marszałek, A.; Miranda, L. D. Medina; Michałowski, J.; Moderski, R.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Paśko, P.; Pech, M.; Schovanek, P.; Seweryn, K.; Sliusar, V.; Skowron, K.; Stawarz, Ł.; Stodulska, M.; Stodulski, M.; Walter, R.; Więcek, M.; Zagdański, A.; CTA Consortium

2017-01-01

The Small Size Telescope with Single Mirror (SST-1M) is one of the proposed types of Small Size Telescopes (SST) for the Cherenkov Telescope Array (CTA). About 70 SST telescopes will be part the CTA southern array which will also include Medium Sized Telescopes (MST) in its threshold configuration. Optimized for the detection of gamma rays in the energy range from 5 TeV to 300 TeV, the SST-1M uses a Davies-Cotton optics with a 4 m dish diameter with a field of view of 9°. The Cherenkov light resulting from the interaction of the gamma-rays in the atmosphere is focused onto a 88 cm side-to-side hexagonal photo-detection plane. The latter is composed of 1296 hollow light guides coupled to large area hexagonal silicon photomultipliers (SiPM). The SiPM readout is fully digital readout as for the trigger system. The compact and lightweight design of the SST-1M camera offiers very high performance ideal for gamma-ray observation requirement. In this contribution, the concept, design, performance and status of the first telescope prototype are presented.

The GCT camera for the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Lapington, J. S.; Abchiche, A.; Allan, D.; Amans, J.-P.; Armstrong, T. P.; Balzer, A.; Berge, D.; Boisson, C.; Bousquet, J.-J.; Bose, R.; Brown, A. M.; Bryan, M.; Buchholtz, G.; Buckley, J.; Chadwick, P. M.; Costantini, H.; Cotter, G.; Daniel, M. K.; De Franco, A.; De Frondat, F.; Dournaux, J.-L.; Dumas, D.; Ernenwein, J.-P.; Fasola, G.; Funk, S.; Gironnet, J.; Graham, J. A.; Greenshaw, T.; Hervet, O.; Hidaka, N.; Hinton, J. A.; Huet, J.-M.; Jankowsky, D.; Jegouzo, I.; Jogler, T.; Kawashima, T.; Kraus, M.; Laporte, P.; Leach, S.; Lefaucheur, J.; Markoff, S.; Melse, T.; Minaya, I. A.; Mohrmann, L.; Molyneux, P.; Moore, P.; Nolan, S. J.; Okumura, A.; Osborne, J. P.; Parsons, R. D.; Rosen, S.; Ross, D.; Rowell, G.; Rulten, C. B.; Sato, Y.; Sayede, F.; Schmoll, J.; Schoorlemmer, H.; Servillat, M.; Sol, H.; Stamatescu, V.; Stephan, M.; Stuik, R.; Sykes, J.; Tajima, H.; Thornhill, J.; Tibaldo, L.; Trichard, C.; Varner, G.; Vink, J.; Watson, J. J.; White, R.; Yamane, N.; Zech, A.; Zink, A.; Zorn, J.; CTA Consortium

2017-12-01

The Gamma Cherenkov Telescope (GCT) is one of the designs proposed for the Small Sized Telescope (SST) section of the Cherenkov Telescope Array (CTA). The GCT uses dual-mirror optics, resulting in a compact telescope with good image quality and a large field of view with a smaller, more economical, camera than is achievable with conventional single mirror solutions. The photon counting GCT camera is designed to record the flashes of atmospheric Cherenkov light from gamma and cosmic ray initiated cascades, which last only a few tens of nanoseconds. The GCT optics require that the camera detectors follow a convex surface with a radius of curvature of 1 m and a diameter of 35 cm, which is approximated by tiling the focal plane with 32 modules. The first camera prototype is equipped with multi-anode photomultipliers, each comprising an 8×8 array of 6×6 mm2 pixels to provide the required angular scale, adding up to 2048 pixels in total. Detector signals are shaped, amplified and digitised by electronics based on custom ASICs that provide digitisation at 1 GSample/s. The camera is self-triggering, retaining images where the focal plane light distribution matches predefined spatial and temporal criteria. The electronics are housed in the liquid-cooled, sealed camera enclosure. LED flashers at the corners of the focal plane provide a calibration source via reflection from the secondary mirror. The first GCT camera prototype underwent preliminary laboratory tests last year. In November 2015, the camera was installed on a prototype GCT telescope (SST-GATE) in Paris and was used to successfully record the first Cherenkov light of any CTA prototype, and the first Cherenkov light seen with such a dual-mirror optical system. A second full-camera prototype based on Silicon Photomultipliers is under construction. Up to 35 GCTs are envisaged for CTA.

A comparison between the use of a shadow shield whole body counter and an uncollimated gamma camera ain the assessment of the seven-day retention of SeHCAT.

PubMed

Hames, T K; Condon, B R; Fleming, J S; Phillips, G; Holdstock, G; Smith, C L; Howlett, P J; Ackery, D

1984-07-01

We have compared the 7-day retention of the radioisotope bile salt analogue SeHCAT (75Se-23-selena-25-homotaurocholate), by whole body counting and by uncollimated gamma camera measurement, in phantoms and in 25 patients with inflammatory bowel disease. The results correlate with a linear correlation coefficient of 0.96. An uncollimated gamma camera can be used to assess bile acid malabsorption when a whole body radioactivity monitor is not available.

Evaluation of Timepix3 based CdTe photon counting detector for fully spectroscopic small animal SPECT imaging

NASA Astrophysics Data System (ADS)

Trojanova, E.; Jakubek, J.; Turecek, D.; Sykora, V.; Francova, P.; Kolarova, V.; Sefc, L.

2018-01-01

The imaging method of SPECT (Single Photon Emission Computed Tomography) is used in nuclear medicine for diagnostics of various diseases or organs malfunctions. The distribution of medically injected, inhaled, or ingested radionuclides (radiotracers) in the patient body is imaged using gamma-ray sensitive camera with suitable imaging collimator. The 3D image is then calculated by combining many images taken from different observation angles. Most of SPECT systems use scintillator based cameras. These cameras do not provide good energy resolution and do not allow efficient suppression of unwanted signals such as those caused by Compton scattering. The main goal of this work is evaluation of Timepix3 detector properties for SPECT method for functional imaging of small animals during preclinical studies. Advantageous Timepix3 properties such as energy and spatial resolution are exploited for significant image quality improvement. Preliminary measurements were performed on specially prepared plastic phantom with cavities filled by radioisotopes and then repeated with in vivo mouse sample.

Slant-hole collimator, dual mode sterotactic localization method

DOEpatents

Weisenberger, Andrew G.

2002-01-01

The use of a slant-hole collimator in the gamma camera of dual mode stereotactic localization apparatus allows the acquisition of a stereo pair of scintimammographic images without repositioning of the gamma camera between image acquisitions.

Comparison of myocardial perfusion imaging between the new high-speed gamma camera and the standard anger camera.

PubMed

Tanaka, Hirokazu; Chikamori, Taishiro; Hida, Satoshi; Uchida, Kenji; Igarashi, Yuko; Yokoyama, Tsuyoshi; Takahashi, Masaki; Shiba, Chie; Yoshimura, Mana; Tokuuye, Koichi; Yamashina, Akira

2013-01-01

Cadmium-zinc-telluride (CZT) solid-state detectors have been recently introduced into the field of myocardial perfusion imaging. The aim of this study was to prospectively compare the diagnostic performance of the CZT high-speed gamma camera (Discovery NM 530c) with that of the standard 3-head gamma camera in the same group of patients. The study group consisted of 150 consecutive patients who underwent a 1-day stress-rest (99m)Tc-sestamibi or tetrofosmin imaging protocol. Image acquisition was performed first on a standard gamma camera with a 15-min scan time each for stress and for rest. All scans were immediately repeated on a CZT camera with a 5-min scan time for stress and a 3-min scan time for rest, using list mode. The correlations between the CZT camera and the standard camera for perfusion and function analyses were strong within narrow Bland-Altman limits of agreement. Using list mode analysis, image quality for stress was rated as good or excellent in 97% of the 3-min scans, and in 100% of the ≥4-min scans. For CZT scans at rest, similarly, image quality was rated as good or excellent in 94% of the 1-min scans, and in 100% of the ≥2-min scans. The novel CZT camera provides excellent image quality, which is equivalent to standard myocardial single-photon emission computed tomography, despite a short scan time of less than half of the standard time.

Investigations of Au-198 as radiotracer in laboratory porous media using gamma camera: a preliminary study

NASA Astrophysics Data System (ADS)

Othman, N.; Kamal, W. H. B. Wan; Yusof, N. H.; Engku Chik, E. M. F.; Yunos, M. A. S.; Adnan, M. A. K.; Shari, M. R.

2018-01-01

Preliminary experiment has been carried out using irradiated Au-198 as radiotracer inside the laboratory porous media. The objectives are to check the compatibility of Au-198 as the radiotracer inside the porous media as well as to provide insights of fluid hydrodynamics inside the media using gamma camera.198Au is gamma emitter isotope with half-life of 2.7 days and energy of 0.41 MeV (99%). The porous media consists of fine sandstone with grain size 850μm, lubricant as the mimic of original oil in plant (OOIP) or trapped oil and a layer of cement on top of the rig as the bed rock. Gamma camera is arranged next to the porous media in order to capture the movement of radiotracer which has been set to 1minute per frame. Initially, the gold wire which has isotope of 197Au was irradiated inside the rotary rack of Reactor Triga PUSPATI (RTP) to produce 198Au. RTP is located in Nuclear Malaysia, Bangi has energy of 750kW and neutron flux of 5 × 102 n/cm2/s. 198Au, which is in liquid form, is injected inside the porous media and monitored and recorded by gamma camera. The gamma camera gives a quantitative determination of local fluid saturations over the area of observation.

A high-speed digital camera system for the observation of rapid H-alpha fluctuations in solar flares

NASA Technical Reports Server (NTRS)

Kiplinger, Alan L.; Dennis, Brian R.; Orwig, Larry E.

1989-01-01

Researchers developed a prototype digital camera system for obtaining H-alpha images of solar flares with 0.1 s time resolution. They intend to operate this system in conjunction with SMM's Hard X Ray Burst Spectrometer, with x ray instruments which will be available on the Gamma Ray Observatory and eventually with the Gamma Ray Imaging Device (GRID), and with the High Resolution Gamma-Ray and Hard X Ray Spectrometer (HIREGS) which are being developed for the Max '91 program. The digital camera has recently proven to be successful as a one camera system operating in the blue wing of H-alpha during the first Max '91 campaign. Construction and procurement of a second and possibly a third camera for simultaneous observations at other wavelengths are underway as are analyses of the campaign data.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lemaire, H.; Barat, E.; Carrel, F.

In this work, we tested Maximum likelihood expectation-maximization (MLEM) algorithms optimized for gamma imaging applications on two recent coded mask gamma cameras. We respectively took advantage of the characteristics of the GAMPIX and Caliste HD-based gamma cameras: noise reduction thanks to mask/anti-mask procedure but limited energy resolution for GAMPIX, high energy resolution for Caliste HD. One of our short-term perspectives is the test of MAPEM algorithms integrating specific prior values for the data to reconstruct adapted to the gamma imaging topic. (authors)

SU-G-IeP4-12: Performance of In-111 Coincident Gamma-Ray Counting: A Monte Carlo Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pahlka, R; Kappadath, S; Mawlawi, O

2016-06-15

Purpose: The decay of In-111 results in a non-isotropic gamma-ray cascade, which is normally imaged using a gamma camera. Creating images with a gamma camera using coincident gamma-rays from In-111 has not been previously studied. Our objective was to explore the feasibility of imaging this cascade as coincidence events and to determine the optimal timing resolution and source activity using Monte Carlo simulations. Methods: GEANT4 was used to simulate the decay of the In-111 nucleus and to model the gamma camera. Each photon emission was assigned a timestamp, and the time delay and angular separation for the second gamma-ray inmore » the cascade was consistent with the known intermediate state half-life of 85ns. The gamma-rays are transported through a model of a Siemens dual head Symbia “S” gamma camera with a 5/8-inch thick crystal and medium energy collimators. A true coincident event was defined as a single 171keV gamma-ray followed by a single 245keV gamma-ray within a specified time window (or vice versa). Several source activities (ranging from 10uCi to 5mCi) with and without incorporation of background counts were then simulated. Each simulation was analyzed using varying time windows to assess random events. The noise equivalent count rate (NECR) was computed based on the number of true and random counts for each combination of activity and time window. No scatter events were assumed since sources were simulated in air. Results: As expected, increasing the timing window increased the total number of observed coincidences albeit at the expense of true coincidences. A timing window range of 200–500ns maximizes the NECR at clinically-used source activities. The background rate did not significantly alter the maximum NECR. Conclusion: This work suggests coincident measurements of In-111 gamma-ray decay can be performed with commercial gamma cameras at clinically-relevant activities. Work is ongoing to assess useful clinical applications.« less

Gamma ray camera

DOEpatents

Perez-Mendez, V.

1997-01-21

A gamma ray camera is disclosed for detecting rays emanating from a radiation source such as an isotope. The gamma ray camera includes a sensor array formed of a visible light crystal for converting incident gamma rays to a plurality of corresponding visible light photons, and a photosensor array responsive to the visible light photons in order to form an electronic image of the radiation therefrom. The photosensor array is adapted to record an integrated amount of charge proportional to the incident gamma rays closest to it, and includes a transparent metallic layer, photodiode consisting of a p-i-n structure formed on one side of the transparent metallic layer, and comprising an upper p-type layer, an intermediate layer and a lower n-type layer. In the preferred mode, the scintillator crystal is composed essentially of a cesium iodide (CsI) crystal preferably doped with a predetermined amount impurity, and the p-type upper intermediate layers and said n-type layer are essentially composed of hydrogenated amorphous silicon (a-Si:H). The gamma ray camera further includes a collimator interposed between the radiation source and the sensor array, and a readout circuit formed on one side of the photosensor array. 6 figs.

Gamma ray camera

DOEpatents

Perez-Mendez, Victor

1997-01-01

A gamma ray camera for detecting rays emanating from a radiation source such as an isotope. The gamma ray camera includes a sensor array formed of a visible light crystal for converting incident gamma rays to a plurality of corresponding visible light photons, and a photosensor array responsive to the visible light photons in order to form an electronic image of the radiation therefrom. The photosensor array is adapted to record an integrated amount of charge proportional to the incident gamma rays closest to it, and includes a transparent metallic layer, photodiode consisting of a p-i-n structure formed on one side of the transparent metallic layer, and comprising an upper p-type layer, an intermediate layer and a lower n-type layer. In the preferred mode, the scintillator crystal is composed essentially of a cesium iodide (CsI) crystal preferably doped with a predetermined amount impurity, and the p-type upper intermediate layers and said n-type layer are essentially composed of hydrogenated amorphous silicon (a-Si:H). The gamma ray camera further includes a collimator interposed between the radiation source and the sensor array, and a readout circuit formed on one side of the photosensor array.

Inauguration and first light of the GCT-M prototype for the Cherenkov telescope array

NASA Astrophysics Data System (ADS)

Watson, J. J.; De Franco, A.; Abchiche, A.; Allan, D.; Amans, J.-P.; Armstrong, T. P.; Balzer, A.; Berge, D.; Boisson, C.; Bousquet, J.-J.; Brown, A. M.; Bryan, M.; Buchholtz, G.; Chadwick, P. M.; Costantini, H.; Cotter, G.; Daniel, M. K.; De Frondat, F.; Dournaux, J.-L.; Dumas, D.; Ernenwein, J.-P.; Fasola, G.; Funk, S.; Gironnet, J.; Graham, J. A.; Greenshaw, T.; Hervet, O.; Hidaka, N.; Hinton, J. A.; Huet, J.-M.; Jegouzo, I.; Jogler, T.; Kraus, M.; Lapington, J. S.; Laporte, P.; Lefaucheur, J.; Markoff, S.; Melse, T.; Mohrmann, L.; Molyneux, P.; Nolan, S. J.; Okumura, A.; Osborne, J. P.; Parsons, R. D.; Rosen, S.; Ross, D.; Rowell, G.; Rulten, C. B.; Sato, Y.; Sayède, F.; Schmoll, J.; Schoorlemmer, H.; Servillat, M.; Sol, H.; Stamatescu, V.; Stephan, M.; Stuik, R.; Sykes, J.; Tajima, H.; Thornhill, J.; Tibaldo, L.; Trichard, C.; Vink, J.; White, R.; Yamane, N.; Zech, A.; Zink, A.; Zorn, J.; CTA Consortium

2017-01-01

The Gamma-ray Cherenkov Telescope (GCT) is a candidate for the Small Size Telescopes (SSTs) of the Cherenkov Telescope Array (CTA). Its purpose is to extend the sensitivity of CTA to gamma-ray energies reaching 300 TeV. Its dual-mirror optical design and curved focal plane enables the use of a compact camera of 0.4 m diameter, while achieving a field of view of above 8 degrees. Through the use of the digitising TARGET ASICs, the Cherenkov flash is sampled once per nanosecond contin-uously and then digitised when triggering conditions are met within the analogue outputs of the photosensors. Entire waveforms (typically covering 96 ns) for all 2048 pixels are then stored for analysis, allowing for a broad spectrum of investigations to be performed on the data. Two prototypes of the GCT camera are under development, with differing photosensors: Multi-Anode Photomultipliers (MAPMs) and Silicon Photomultipliers (SiPMs). During November 2015, the GCT MAPM (GCT-M) prototype camera was integrated onto the GCT structure at the Observatoire de Paris-Meudon, where it observed the first Cherenkov light detected by a prototype instrument for CTA.

Portable gamma camera guidance in sentinel lymph node biopsy: prospective observational study of consecutive cases.

PubMed

Peral Rubio, F; de La Riva, P; Moreno-Ramírez, D; Ferrándiz-Pulido, L

2015-06-01

Sentinel lymph node biopsy is the most important tool available for node staging in patients with melanoma. To analyze sentinel lymph node detection and dissection with radio guidance from a portable gamma camera. To assess the number of complications attributable to this biopsy technique. Prospective observational study of a consecutive series of patients undergoing radioguided sentinel lymph node biopsy. We analyzed agreement between nodes detected by presurgical lymphography, those detected by the gamma camera, and those finally dissected. A total of 29 patients (17 women [62.5%] and 12 men [37.5%]) were enrolled. The mean age was 52.6 years (range, 26-82 years). The sentinel node was dissected from all patients; secondary nodes were dissected from some. In 16 cases (55.2%), there was agreement between the number of nodes detected by lymphography, those detected by the gamma camera, and those finally dissected. The only complications observed were seromas (3.64%). No cases of wound dehiscence, infection, hematoma, or hemorrhage were observed. Portable gamma-camera radio guidance may be of use in improving the detection and dissection of sentinel lymph nodes and may also reduce complications. These goals are essential in a procedure whose purpose is melanoma staging. Copyright © 2014 Elsevier España, S.L.U. and AEDV. All rights reserved.

Camera Concepts for the Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Nepomuk Otte, Adam

2009-05-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. The incorporation of trigger electronics and signal digitization into the camera are under study. Given the size of AGIS, the camera must be reliable, robust, and cost effective. We are investigating several directions that include innovative technologies such as Geiger-mode avalanche-photodiodes as a possible detector and switched capacitor arrays for the digitization.

Quality controls for gamma cameras and PET cameras: development of a free open-source ImageJ program

NASA Astrophysics Data System (ADS)

Carlier, Thomas; Ferrer, Ludovic; Berruchon, Jean B.; Cuissard, Regis; Martineau, Adeline; Loonis, Pierre; Couturier, Olivier

2005-04-01

Acquisition data and treatments for quality controls of gamma cameras and Positron Emission Tomography (PET) cameras are commonly performed with dedicated program packages, which are running only on manufactured computers and differ from each other, depending on camera company and program versions. The aim of this work was to develop a free open-source program (written in JAVA language) to analyze data for quality control of gamma cameras and PET cameras. The program is based on the free application software ImageJ and can be easily loaded on any computer operating system (OS) and thus on any type of computer in every nuclear medicine department. Based on standard parameters of quality control, this program includes 1) for gamma camera: a rotation center control (extracted from the American Association of Physics in Medicine, AAPM, norms) and two uniformity controls (extracted from the Institute of Physics and Engineering in Medicine, IPEM, and National Electronic Manufacturers Association, NEMA, norms). 2) For PET systems, three quality controls recently defined by the French Medical Physicist Society (SFPM), i.e. spatial resolution and uniformity in a reconstructed slice and scatter fraction, are included. The determination of spatial resolution (thanks to the Point Spread Function, PSF, acquisition) allows to compute the Modulation Transfer Function (MTF) in both modalities of cameras. All the control functions are included in a tool box which is a free ImageJ plugin and could be soon downloaded from Internet. Besides, this program offers the possibility to save on HTML format the uniformity quality control results and a warning can be set to automatically inform users in case of abnormal results. The architecture of the program allows users to easily add any other specific quality control program. Finally, this toolkit is an easy and robust tool to perform quality control on gamma cameras and PET cameras based on standard computation parameters, is free, run on any type of computer and will soon be downloadable from the net (http://rsb.info.nih.gov/ij/plugins or http://nucleartoolkit.free.fr).

Full image-processing pipeline in field-programmable gate array for a small endoscopic camera

NASA Astrophysics Data System (ADS)

Mostafa, Sheikh Shanawaz; Sousa, L. Natércia; Ferreira, Nuno Fábio; Sousa, Ricardo M.; Santos, Joao; Wäny, Martin; Morgado-Dias, F.

2017-01-01

Endoscopy is an imaging procedure used for diagnosis as well as for some surgical purposes. The camera used for the endoscopy should be small and able to produce a good quality image or video, to reduce discomfort of the patients, and to increase the efficiency of the medical team. To achieve these fundamental goals, a small endoscopy camera with a footprint of 1 mm×1 mm×1.65 mm is used. Due to the physical properties of the sensors and human vision system limitations, different image-processing algorithms, such as noise reduction, demosaicking, and gamma correction, among others, are needed to faithfully reproduce the image or video. A full image-processing pipeline is implemented using a field-programmable gate array (FPGA) to accomplish a high frame rate of 60 fps with minimum processing delay. Along with this, a viewer has also been developed to display and control the image-processing pipeline. The control and data transfer are done by a USB 3.0 end point in the computer. The full developed system achieves real-time processing of the image and fits in a Xilinx Spartan-6LX150 FPGA.

Optimization and verification of image reconstruction for a Compton camera towards application as an on-line monitor for particle therapy

NASA Astrophysics Data System (ADS)

Taya, T.; Kataoka, J.; Kishimoto, A.; Tagawa, L.; Mochizuki, S.; Toshito, T.; Kimura, M.; Nagao, Y.; Kurita, K.; Yamaguchi, M.; Kawachi, N.

2017-07-01

Particle therapy is an advanced cancer therapy that uses a feature known as the Bragg peak, in which particle beams suddenly lose their energy near the end of their range. The Bragg peak enables particle beams to damage tumors effectively. To achieve precise therapy, the demand for accurate and quantitative imaging of the beam irradiation region or dosage during therapy has increased. The most common method of particle range verification is imaging of annihilation gamma rays by positron emission tomography. Not only 511-keV gamma rays but also prompt gamma rays are generated during therapy; therefore, the Compton camera is expected to be used as an on-line monitor for particle therapy, as it can image these gamma rays in real time. Proton therapy, one of the most common particle therapies, uses a proton beam of approximately 200 MeV, which has a range of ~ 25 cm in water. As gamma rays are emitted along the path of the proton beam, quantitative evaluation of the reconstructed images of diffuse sources becomes crucial, but it is far from being fully developed for Compton camera imaging at present. In this study, we first quantitatively evaluated reconstructed Compton camera images of uniformly distributed diffuse sources, and then confirmed that our Compton camera obtained 3 %(1 σ) and 5 %(1 σ) uniformity for line and plane sources, respectively. Based on this quantitative study, we demonstrated on-line gamma imaging during proton irradiation. Through these studies, we show that the Compton camera is suitable for future use as an on-line monitor for particle therapy.

COMPUTER ANALYSIS OF PLANAR GAMMA CAMERA IMAGES

EPA Science Inventory

COMPUTER ANALYSIS OF PLANAR GAMMA CAMERA IMAGES

T Martonen1 and J Schroeter2

1Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, NC 27711 USA and 2Curriculum in Toxicology, Unive...

21 CFR 892.1100 - Scintillation (gamma) camera.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Scintillation (gamma) camera. 892.1100 Section 892.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... analysis and display equipment, patient and equipment supports, radionuclide anatomical markers, component...

21 CFR 892.1100 - Scintillation (gamma) camera.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Scintillation (gamma) camera. 892.1100 Section 892.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... analysis and display equipment, patient and equipment supports, radionuclide anatomical markers, component...

21 CFR 892.1100 - Scintillation (gamma) camera.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Scintillation (gamma) camera. 892.1100 Section 892.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... analysis and display equipment, patient and equipment supports, radionuclide anatomical markers, component...

Tumor dosimetry for I-131 trastuzumab therapy in a Her2+ NCI N87 xenograft mouse model using the Siemens SYMBIA E gamma camera with a pinhole collimator

NASA Astrophysics Data System (ADS)

Lee, Young Sub; Kim, Jin Su; Deuk Cho, Kyung; Kang, Joo Hyun; Moo Lim, Sang

2015-07-01

We performed imaging and therapy using I-131 trastuzumab and a pinhole collimator attached to a conventional gamma camera for human use in a mouse model. The conventional clinical gamma camera with a 2-mm radius-sized pinhole collimator was used for monitoring the animal model after administration of I-131 trastuzumab The highest and lowest radiation-received organs were osteogenic cells (0.349 mSv/MBq) and skin (0.137 mSv/MBq), respectively. The mean coefficients of variation (%CV) of the effective dose equivalent and effective dose were 0.091 and 0.093 mSv/MBq respectively. We showed the feasibility of the pinholeattached conventional gamma camera for human use for the assessment of dosimetry. Mouse dosimetry and prediction of human dosimetry could be used to provide data for the safety and efficacy of newly developed therapeutic schemes.

SU-E-E-06: Teaching About the Gamma Camera and Ultrasound Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowe, M; Spiro, A; Vogel, R

Purpose: Instructional modules on applications of physics in medicine are being developed. The target audience consists of students who have had an introductory undergraduate physics course. This presentation will concentrate on an active learning approach to teach the principles of the gamma camera. There will also be a description of an apparatus to teach ultrasound imaging. Methods: Since a real gamma camera is not feasible in the undergraduate classroom, we have developed two types of optical apparatus that teach the main principles. To understand the collimator, LEDS mimic gamma emitters in the body, and the photons pass through an arraymore » of tubes. The distance, spacing, diameter, and length of the tubes can be varied to understand the effect upon the resolution of the image. To determine the positions of the gamma emitters, a second apparatus uses a movable green laser, fluorescent plastic in lieu of the scintillation crystal, acrylic rods that mimic the PMTs, and a photodetector to measure the intensity. The position of the laser is calculated with a centroid algorithm.To teach the principles of ultrasound imaging, we are using the sound head and pulser box of an educational product, variable gain amplifier, rotation table, digital oscilloscope, Matlab software, and phantoms. Results: Gamma camera curriculum materials have been implemented in the classroom at Loyola in 2014 and 2015. Written work shows good knowledge retention and a more complete understanding of the material. Preliminary ultrasound imaging materials were run in 2015. Conclusion: Active learning methods add another dimension to descriptions in textbooks and are effective in keeping the students engaged during class time. The teaching apparatus for the gamma camera and ultrasound imaging can be expanded to include more cases, and could potentially improve students’ understanding of artifacts and distortions in the images.« less

Novel methods for estimating 3D distributions of radioactive isotopes in materials

NASA Astrophysics Data System (ADS)

Iwamoto, Y.; Kataoka, J.; Kishimoto, A.; Nishiyama, T.; Taya, T.; Okochi, H.; Ogata, H.; Yamamoto, S.

2016-09-01

In recent years, various gamma-ray visualization techniques, or gamma cameras, have been proposed. These techniques are extremely effective for identifying "hot spots" or regions where radioactive isotopes are accumulated. Examples of such would be nuclear-disaster-affected areas such as Fukushima or the vicinity of nuclear reactors. However, the images acquired with a gamma camera do not include distance information between radioactive isotopes and the camera, and hence are "degenerated" in the direction of the isotopes. Moreover, depth information in the images is lost when the isotopes are embedded in materials, such as water, sand, and concrete. Here, we propose two methods of obtaining depth information of radioactive isotopes embedded in materials by comparing (1) their spectra and (2) images of incident gamma rays scattered by the materials and direct gamma rays. In the first method, the spectra of radioactive isotopes and the ratios of scattered to direct gamma rays are obtained. We verify experimentally that the ratio increases with increasing depth, as predicted by simulations. Although the method using energy spectra has been studied for a long time, an advantage of our method is the use of low-energy (50-150 keV) photons as scattered gamma rays. In the second method, the spatial extent of images obtained for direct and scattered gamma rays is compared. By performing detailed Monte Carlo simulations using Geant4, we verify that the spatial extent of the position where gamma rays are scattered increases with increasing depth. To demonstrate this, we are developing various gamma cameras to compare low-energy (scattered) gamma-ray images with fully photo-absorbed gamma-ray images. We also demonstrate that the 3D reconstruction of isotopes/hotspots is possible with our proposed methods. These methods have potential applications in the medical fields, and in severe environments such as the nuclear-disaster-affected areas in Fukushima.

A versatile calibration procedure for portable coded aperture gamma cameras and RGB-D sensors

NASA Astrophysics Data System (ADS)

Paradiso, V.; Crivellaro, A.; Amgarou, K.; de Lanaute, N. Blanc; Fua, P.; Liénard, E.

2018-04-01

The present paper proposes a versatile procedure for the geometrical calibration of coded aperture gamma cameras and RGB-D depth sensors, using only one radioactive point source and a simple experimental set-up. Calibration data is then used for accurately aligning radiation images retrieved by means of the γ-camera with the respective depth images computed with the RGB-D sensor. The system resulting from such a combination is thus able to retrieve, automatically, the distance of radioactive hotspots by means of pixel-wise mapping between gamma and depth images. This procedure is of great interest for a wide number of applications, ranging from precise automatic estimation of the shape and distance of radioactive objects to Augmented Reality systems. Incidentally, the corresponding results validated the choice of a perspective design model for a coded aperture γ-camera.

Development and characterization of a round hand-held silicon photomultiplier based gamma camera for intraoperative imaging

PubMed Central

Popovic, Kosta; McKisson, Jack E.; Kross, Brian; Lee, Seungjoon; McKisson, John; Weisenberger, Andrew G.; Proffitt, James; Stolin, Alexander; Majewski, Stan; Williams, Mark B.

2017-01-01

This paper describes the development of a hand-held gamma camera for intraoperative surgical guidance that is based on silicon photomultiplier (SiPM) technology. The camera incorporates a cerium doped lanthanum bromide (LaBr3:Ce) plate scintillator, an array of 80 SiPM photodetectors and a two-layer parallel-hole collimator. The field of view is circular with a 60 mm diameter. The disk-shaped camera housing is 75 mm in diameter, approximately 40.5 mm thick and has a mass of only 1.4 kg, permitting either hand-held or arm-mounted use. All camera components are integrated on a mobile cart that allows easy transport. The camera was developed for use in surgical procedures including determination of the location and extent of primary carcinomas, detection of secondary lesions and sentinel lymph node biopsy (SLNB). Here we describe the camera design and its principal operating characteristics, including spatial resolution, energy resolution, sensitivity uniformity, and geometric linearity. The gamma camera has an intrinsic spatial resolution of 4.2 mm FWHM, an energy resolution of 21.1 % FWHM at 140 keV, and a sensitivity of 481 and 73 cps/MBq when using the single- and double-layer collimators, respectively. PMID:28286345

Performance of the prototype LaBr3 spectrometer developed for the JET gamma-ray camera upgrade.

PubMed

Rigamonti, D; Muraro, A; Nocente, M; Perseo, V; Boltruczyk, G; Fernandes, A; Figueiredo, J; Giacomelli, L; Gorini, G; Gosk, M; Kiptily, V; Korolczuk, S; Mianowski, S; Murari, A; Pereira, R C; Cippo, E P; Zychor, I; Tardocchi, M

2016-11-01

In this work, we describe the solution developed by the gamma ray camera upgrade enhancement project to improve the spectroscopic properties of the existing JET γ-ray camera. Aim of the project is to enable gamma-ray spectroscopy in JET deuterium-tritium plasmas. A dedicated pilot spectrometer based on a LaBr 3 crystal coupled to a silicon photo-multiplier has been developed. A proper pole zero cancellation network able to shorten the output signal to a length of 120 ns has been implemented allowing for spectroscopy at MHz count rates. The system has been characterized in the laboratory and shows an energy resolution of 5.5% at E γ = 0.662 MeV, which extrapolates favorably in the energy range of interest for gamma-ray emission from fast ions in fusion plasmas.

Development of an omnidirectional gamma-ray imaging Compton camera for low-radiation-level environmental monitoring

NASA Astrophysics Data System (ADS)

Watanabe, Takara; Enomoto, Ryoji; Muraishi, Hiroshi; Katagiri, Hideaki; Kagaya, Mika; Fukushi, Masahiro; Kano, Daisuke; Satoh, Wataru; Takeda, Tohoru; Tanaka, Manobu M.; Tanaka, Souichi; Uchida, Tomohisa; Wada, Kiyoto; Wakamatsu, Ryo

2018-02-01

We have developed an omnidirectional gamma-ray imaging Compton camera for environmental monitoring at low levels of radiation. The camera consisted of only six CsI(Tl) scintillator cubes of 3.5 cm, each of which was readout by super-bialkali photo-multiplier tubes (PMTs). Our camera enables the visualization of the position of gamma-ray sources in all directions (∼4π sr) over a wide energy range between 300 and 1400 keV. The angular resolution (σ) was found to be ∼11°, which was realized using an image-sharpening technique. A high detection efficiency of 18 cps/(µSv/h) for 511 keV (1.6 cps/MBq at 1 m) was achieved, indicating the capability of this camera to visualize hotspots in areas with low-radiation-level contamination from the order of µSv/h to natural background levels. Our proposed technique can be easily used as a low-radiation-level imaging monitor in radiation control areas, such as medical and accelerator facilities.

The core of the nearby S0 galaxy NGC 7457 imaged with the HST planetary camera

NASA Technical Reports Server (NTRS)

Lauer, Tod R.; Faber, S. M.; Holtzman, Jon A.; Baum, William A.; Currie, Douglas G.; Ewald, S. P.; Groth, Edward J.; Hester, J. Jeff; Kelsall, T.

1991-01-01

A brief analysis is presented of images of the nearby S0 galaxy NGC 7457 obtained with the HST Planetary Camera. While the galaxy remains unresolved with the HST, the images reveal that any core most likely has r(c) less than 0.052 arcsec. The light distribution is consistent with a gamma = -1.0 power law inward to the resolution limit, with a possible stellar nucleus with luminosity of 10 million solar. This result represents the first observation outside the Local Group of a galaxy nucleus at this spatial resolution, and it suggests that such small, high surface brightness cores may be common.

Mini gamma camera, camera system and method of use

DOEpatents

Majewski, Stanislaw; Weisenberger, Andrew G.; Wojcik, Randolph F.

2001-01-01

A gamma camera comprising essentially and in order from the front outer or gamma ray impinging surface: 1) a collimator, 2) a scintillator layer, 3) a light guide, 4) an array of position sensitive, high resolution photomultiplier tubes, and 5) printed circuitry for receipt of the output of the photomultipliers. There is also described, a system wherein the output supplied by the high resolution, position sensitive photomultipiler tubes is communicated to: a) a digitizer and b) a computer where it is processed using advanced image processing techniques and a specific algorithm to calculate the center of gravity of any abnormality observed during imaging, and c) optional image display and telecommunications ports.

A SPECT Scanner for Rodent Imaging Based on Small-Area Gamma Cameras

NASA Astrophysics Data System (ADS)

Lage, Eduardo; Villena, José L.; Tapias, Gustavo; Martinez, Naira P.; Soto-Montenegro, Maria L.; Abella, Mónica; Sisniega, Alejandro; Pino, Francisco; Ros, Domènec; Pavia, Javier; Desco, Manuel; Vaquero, Juan J.

2010-10-01

We developed a cost-effective SPECT scanner prototype (rSPECT) for in vivo imaging of rodents based on small-area gamma cameras. Each detector consists of a position-sensitive photomultiplier tube (PS-PMT) coupled to a 30 x 30 Nal(Tl) scintillator array and electronics attached to the PS-PMT sockets for adapting the detector signals to an in-house developed data acquisition system. The detector components are enclosed in a lead-shielded case with a receptacle to insert the collimators. System performance was assessed using 99mTc for a high-resolution parallel-hole collimator, and for a 0.75-mm pinhole collimator with a 60° aperture angle and a 42-mm collimator length. The energy resolution is about 10.7% of the photopeak energy. The overall system sensitivity is about 3 cps/μCi/detector and planar spatial resolution ranges from 2.4 mm at 1 cm source-to-collimator distance to 4.1 mm at 4.5 cm with parallel-hole collimators. With pinhole collimators planar spatial resolution ranges from 1.2 mm at 1 cm source-to-collimator distance to 2.4 mm at 4.5 cm; sensitivity at these distances ranges from 2.8 to 0.5 cps/μCi/detector. Tomographic hot-rod phantom images are presented together with images of bone, myocardium and brain of living rodents to demonstrate the feasibility of preclinical small-animal studies with the rSPECT.

Gamma-ray imaging system for real-time measurements in nuclear waste characterisation

NASA Astrophysics Data System (ADS)

Caballero, L.; Albiol Colomer, F.; Corbi Bellot, A.; Domingo-Pardo, C.; Leganés Nieto, J. L.; Agramunt Ros, J.; Contreras, P.; Monserrate, M.; Olleros Rodríguez, P.; Pérez Magán, D. L.

2018-03-01

A compact, portable and large field-of-view gamma camera that is able to identify, locate and quantify gamma-ray emitting radioisotopes in real-time has been developed. The device delivers spectroscopic and imaging capabilities that enable its use it in a variety of nuclear waste characterisation scenarios, such as radioactivity monitoring in nuclear power plants and more specifically for the decommissioning of nuclear facilities. The technical development of this apparatus and some examples of its application in field measurements are reported in this article. The performance of the presented gamma-camera is also benchmarked against other conventional techniques.

Photodetectors for the Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Wagner, Robert G.; Advanced Gamma-ray Imaging System AGIS Collaboration

2010-03-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation very high energy gamma-ray observatory. Design goals include an order of magnitude better sensitivity, better angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. Given the scale of AGIS, the camera must be reliable and cost effective. The Schwarzschild-Couder optical design yields a smaller plate scale than present-day Cherenkov telescopes, enabling the use of more compact, multi-pixel devices, including multianode photomultipliers or Geiger avalanche photodiodes. We present the conceptual design of the focal plane for the camera and results from testing candidate! focal plane sensors.

Performance of the prototype LaBr{sub 3} spectrometer developed for the JET gamma-ray camera upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rigamonti, D., E-mail: davide.rigamonti@mib.infn.it; Nocente, M.; Gorini, G.

2016-11-15

In this work, we describe the solution developed by the gamma ray camera upgrade enhancement project to improve the spectroscopic properties of the existing JET γ-ray camera. Aim of the project is to enable gamma-ray spectroscopy in JET deuterium-tritium plasmas. A dedicated pilot spectrometer based on a LaBr{sub 3} crystal coupled to a silicon photo-multiplier has been developed. A proper pole zero cancellation network able to shorten the output signal to a length of 120 ns has been implemented allowing for spectroscopy at MHz count rates. The system has been characterized in the laboratory and shows an energy resolution ofmore » 5.5% at E{sub γ} = 0.662 MeV, which extrapolates favorably in the energy range of interest for gamma-ray emission from fast ions in fusion plasmas.« less

Copper crystal lens for medical imaging: first results

NASA Astrophysics Data System (ADS)

Roa, Dante E.; Smither, Robert K.

2001-06-01

A copper crystal lens designed to focus gamma ray energies of 100 to 200 keV has been assembled at Argonne National Laboratory. In particular, the lens has been optimized to focus the 140.6 keV gamma rays from technetium-99 m typically used in radioactive tracers. This new approach to medical imaging relies on crystal diffraction to focus incoming gamma rays in a manner similar to a simple convex lens focusing visible light. The lens is envisioned to be part of an array of lenses that can be used as a complementary technique to gamma cameras for localized scans of suspected tumor regions in the body. In addition, a 2- lens array can be used to scan a woman's breast in search of tumors with no discomfort to the patient. The incoming gamma rays are diffracted by a set of 828 copper crystal cubes arranged in 13 concentric rings, which focus the gamma rays into a very small area on a well-shielded NaI detector. Experiments performance with technetium-99 m and cobalt 57 radioactive sources indicate that a 6-lens array should be capable of detecting sources with (mu) Ci strength.

A feasibility study of an integrated NIR/gamma/visible imaging system for endoscopic sentinel lymph node mapping.

PubMed

Kang, Han Gyu; Lee, Ho-Young; Kim, Kyeong Min; Song, Seong-Hyun; Hong, Gun Chul; Hong, Seong Jong

2017-01-01

The aim of this study is to integrate NIR, gamma, and visible imaging tools into a single endoscopic system to overcome the limitation of NIR using gamma imaging and to demonstrate the feasibility of endoscopic NIR/gamma/visible fusion imaging for sentinel lymph node (SLN) mapping with a small animal. The endoscopic NIR/gamma/visible imaging system consists of a tungsten pinhole collimator, a plastic focusing lens, a BGO crystal (11 × 11 × 2 mm 3 ), a fiber-optic taper (front = 11 × 11 mm 2 , end = 4 × 4 mm 2 ), a 122-cm long endoscopic fiber bundle, an NIR emission filter, a relay lens, and a CCD camera. A custom-made Derenzo-like phantom filled with a mixture of 99m Tc and indocyanine green (ICG) was used to assess the spatial resolution of the NIR and gamma images. The ICG fluorophore was excited using a light-emitting diode (LED) with an excitation filter (723-758 nm), and the emitted fluorescence photons were detected with an emission filter (780-820 nm) for a duration of 100 ms. Subsequently, the 99m Tc distribution in the phantom was imaged for 3 min. The feasibility of in vivo SLN mapping with a mouse was investigated by injecting a mixture of 99m Tc-antimony sulfur colloid (12 MBq) and ICG (0.1 mL) into the right paw of the mouse (C57/B6) subcutaneously. After one hour, NIR, gamma, and visible images were acquired sequentially. Subsequently, the dissected SLN was imaged in the same way as the in vivo SLN mapping. The NIR, gamma, and visible images of the Derenzo-like phantom can be obtained with the proposed endoscopic imaging system. The NIR/gamma/visible fusion image of the SLN showed a good correlation among the NIR, gamma, and visible images both for the in vivo and ex vivo imaging. We demonstrated the feasibility of the integrated NIR/gamma/visible imaging system using a single endoscopic fiber bundle. In future, we plan to investigate miniaturization of the endoscope head and simultaneous NIR/gamma/visible imaging with dichroic mirrors and three CCD cameras. © 2016 American Association of Physicists in Medicine.

Molecular breast imaging using a dedicated high-performance instrument

NASA Astrophysics Data System (ADS)

O'Connor, Michael K.; Wagenaar, Douglas; Hruska, Carrie B.; Phillips, Stephen; Caravaglia, Gina; Rhodes, Deborah

2006-08-01

In women with radiographically dense breasts, the sensitivity of mammography is less than 50%. With the increase in the percent of women with dense breasts, it is important to look at alternative screening techniques for this population. This article reviews the strengths and weaknesses of current imaging techniques and focuses on recent developments in semiconductor-based gamma camera systems that offer significant improvements in image quality over that achievable with single-crystal sodium iodide systems. We have developed a technique known as Molecular Breast Imaging (MBI) using small field of view Cadmium Zinc Telluride (CZT) gamma cameras that permits the breast to be imaged in a similar manner to mammography, using light pain-free compression. Computer simulations and experimental studies have shown that use of low-energy high sensitivity collimation coupled with the excellent energy resolution and intrinsic spatial resolution of CZT detectors provides optimum image quality for the detection of small breast lesions. Preliminary clinical studies with a prototype dual-detector system have demonstrated that Molecular Breast Imaging has a sensitivity of ~90% for the detection of breast tumors less than 10 mm in diameter. By comparison, conventional scintimammography only achieves a sensitivity of 50% in the detection of lesions < 10 mm. Because Molecular Breast Imaging is not affected by breast density, this technique may offer an important adjunct to mammography in the evaluation of women with dense breast parenchyma.

[Evaluation of crossing calibration of (123)I-MIBG H/M ration, with the IDW scatter correction method, on different gamma camera systems].

PubMed

Kittaka, Daisuke; Takase, Tadashi; Akiyama, Masayuki; Nakazawa, Yasuo; Shinozuka, Akira; Shirai, Muneaki

2011-01-01

(123)I-MIBG Heart-to-Mediastinum activity ratio (H/M) is commonly used as an indicator of relative myocardial (123)I-MIBG uptake. H/M ratios reflect myocardial sympathetic nerve function, therefore it is a useful parameter to assess regional myocardial sympathetic denervation in various cardiac diseases. However, H/M ratio values differ by site, gamma camera system, position and size of region of interest (ROI), and collimator. In addition to these factors, 529 keV scatter component may also affect (123)I-MIBG H/M ratio. In this study, we examined whether the H/M ratio shows correlation between two different gamma camera systems and that sought for H/M ratio calculation formula. Moreover, we assessed the feasibility of (123)I Dual Window (IDW) method, which is a scatter correction method, and compared H/M ratios with and without IDW method. H/M ratio displayed a good correlation between two gamma camera systems. Additionally, we were able to create a new H/M calculation formula. These results indicated that the IDW method is a useful scatter correction method for calculating (123)I-MIBG H/M ratios.

Development and calibration of a new gamma camera detector using large square Photomultiplier Tubes

NASA Astrophysics Data System (ADS)

Zeraatkar, N.; Sajedi, S.; Teimourian Fard, B.; Kaviani, S.; Akbarzadeh, A.; Farahani, M. H.; Sarkar, S.; Ay, M. R.

2017-09-01

Large area scintillation detectors applied in gamma cameras as well as Single Photon Computed Tomography (SPECT) systems, have a major role in in-vivo functional imaging. Most of the gamma detectors utilize hexagonal arrangement of Photomultiplier Tubes (PMTs). In this work we applied large square-shaped PMTs with row/column arrangement and positioning. The Use of large square PMTs reduces dead zones in the detector surface. However, the conventional center of gravity method for positioning may not introduce an acceptable result. Hence, the digital correlated signal enhancement (CSE) algorithm was optimized to obtain better linearity and spatial resolution in the developed detector. The performance of the developed detector was evaluated based on NEMA-NU1-2007 standard. The acquired images using this method showed acceptable uniformity and linearity comparing to three commercial gamma cameras. Also the intrinsic and extrinsic spatial resolutions with low-energy high-resolution (LEHR) collimator at 10 cm from surface of the detector were 3.7 mm and 7.5 mm, respectively. The energy resolution of the camera was measured 9.5%. The performance evaluation demonstrated that the developed detector maintains image quality with a reduced number of used PMTs relative to the detection area.

Design of optimal collimation for dedicated molecular breast imaging systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weinmann, Amanda L.; Hruska, Carrie B.; O'Connor, Michael K.

2009-03-15

Molecular breast imaging (MBI) is a functional imaging technique that uses specialized small field-of-view gamma cameras to detect the preferential uptake of a radiotracer in breast lesions. MBI has potential to be a useful adjunct method to screening mammography for the detection of occult breast cancer. However, a current limitation of MBI is the high radiation dose (a factor of 7-10 times that of screening mammography) associated with current technology. The purpose of this study was to optimize the gamma camera collimation with the aim of improving sensitivity while retaining adequate resolution for the detection of sub-10-mm lesions. Square-hole collimatorsmore » with holes matched to the pixilated cadmium zinc telluride detector elements of the MBI system were designed. Data from MBI patient studies and parameters of existing dual-head MBI systems were used to guide the range of desired collimator resolutions, source-to-collimator distances, pixel sizes, and collimator materials that were examined. General equations describing collimator performance for a conventional gamma camera were used in the design process along with several important adjustments to account for the specialized imaging geometry of the MBI system. Both theoretical calculations and a Monte Carlo model were used to measure the geometric efficiency (or sensitivity) and resolution of each designed collimator. Results showed that through optimal collimation, collimator sensitivity could be improved by factors of 1.5-3.2, while maintaining a collimator resolution of either {<=}5 or {<=}7.5 mm at a distance of 3 cm from the collimator face. These gains in collimator sensitivity permit an inversely proportional drop in the required dose to perform MBI.« less

The single mirror small size telescope (SST-1M) of the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Aguilar, J. A.; Bilnik, W.; Borkowski, J.; Cadoux, F.; Christov, A.; della Volpe, D.; Favre, Y.; Heller, M.; Kasperek, J.; Lyard, E.; Marszałek, A.; Moderski, R.; Montaruli, T.; Porcelli, A.; Prandini, E.; Rajda, P.; Rameez, M.; Schioppa, E., Jr.; Troyano Pujadas, I.; Zietara, K.; Blocki, J.; Bogacz, L.; Bulik, T.; Frankowski, A.; Grudzinska, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Lalik, K.; Mach, E.; Mandat, D.; Michałowski, J.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Paśko, P.; Pech, M.; Schovanek, P.; Seweryn, K.; Skowron, K.; Sliusar, V.; Stawarz, L.; Stodulska, M.; Stodulski, M.; Toscano, S.; Walter, R.; WiÈ©cek, M.; Zagdański, A.

2016-07-01

The Small Size Telescope with Single Mirror (SST-1M) is one of the proposed types of Small Size Telescopes (SST) for the Cherenkov Telescope Array (CTA). The CTA south array will be composed of about 100 telescopes, out of which about 70 are of SST class, which are optimized for the detection of gamma rays in the energy range from 5 TeV to 300 TeV. The SST-1M implements a Davies-Cotton optics with a 4 m dish diameter with a field of view of 9°. The Cherenkov light produced in atmospheric showers is focused onto a 88 cm wide hexagonal photo-detection plane, composed of 1296 custom designed large area hexagonal silicon photomultipliers (SiPM) and a fully digital readout and trigger system. The SST-1M camera has been designed to provide high performance in a robust as well as compact and lightweight design. In this contribution, we review the different steps that led to the realization of the telescope prototype and its innovative camera.

Quantitative investigation of a novel small field of view hybrid gamma camera (HGC) capability for sentinel lymph node detection

PubMed Central

Lees, John E; Bugby, Sarah L; Jambi, Layal K; Perkins, Alan C

2016-01-01

Objective: The hybrid gamma camera (HGC) has been developed to enhance the localization of radiopharmaceutical uptake in targeted tissues during surgical procedures such as sentinel lymph node (SLN) biopsy. To assess the capability of the HGC, a lymph node contrast (LNC) phantom was constructed to simulate medical scenarios of varying radioactivity concentrations and SLN size. Methods: The phantom was constructed using two clear acrylic glass plates. The SLNs were simulated by circular wells of diameters ranging from 10 to 2.5 mm (16 wells in total) in 1 plate. The second plate contains four larger rectangular wells to simulate tissue background activity surrounding the SLNs. The activity used to simulate each SLN ranged between 4 and 0.025 MBq. The activity concentration ratio between the background and the activity injected in the SLNs was 1 : 10. The LNC phantom was placed at different depths of scattering material ranging between 5 and 40 mm. The collimator-to-source distance was 120 mm. Image acquisition times ranged from 60 to 240 s. Results: Contrast-to-noise ratio analysis and full-width-at-half-maximum (FWHM) measurements of the simulated SLNs were carried out for the images obtained. Over the range of activities used, the HGC detected between 87.5 and 100% of the SLNs through 20 mm of scattering material and 75–93.75% of the SLNs through 40 mm of scattering material. The FWHM of the detected SLNs ranged between 11.93 and 14.70 mm. Conclusion: The HGC is capable of detecting low accumulation of activity in small SLNs, indicating its usefulness as an intraoperative imaging system during surgical SLN procedures. Advances in knowledge: This study investigates the capability of a novel small-field-of-view (SFOV) HGC to detect low activity uptake in small SLNs. The phantom and procedure described are inexpensive and could be easily replicated and applied to any SFOV camera, to provide a comparison between systems with clinically relevant results. PMID:27537079

A prototype small CdTe gamma camera for radioguided surgery and other imaging applications.

PubMed

Tsuchimochi, Makoto; Sakahara, Harumi; Hayama, Kazuhide; Funaki, Minoru; Ohno, Ryoichi; Shirahata, Takashi; Orskaug, Terje; Maehlum, Gunnar; Yoshioka, Koki; Nygard, Einar

2003-12-01

Gamma probes have been used for sentinel lymph node biopsy in melanoma and breast cancer. However, these probes can provide only radioactivity counts and variable pitch audio output based on the intensity of the detected radioactivity. We have developed a small semiconductor gamma camera (SSGC) that allows visualisation of the size, shape and location of the target tissues. This study is designed to characterise the performance of the SSGC for radioguided surgery of metastatic lesions and for other imaging applications amenable to the smaller format of this prototype imaging system. The detector head had 32 cadmium telluride semiconductor arrays with a total of 1,024 pixels, and with application-specific integrated circuits (ASICs) and a tungsten collimator. The entire assembly was encased in a lead housing measuring 152 mmx166 mmx65 mm. The effective visual field was 44.8 mmx44.8 mm. The energy resolution and imaging aspects were tested. Two spherical 5-mm- and 15-mm-diameter technetium-99m radioactive sources that had activities of 0.15 MBq and 100 MBq, respectively, were used to simulate a sentinel lymph node and an injection site. The relative detectability of these foci by the new detector and a conventional scintillation camera was studied. The prototype was also examined in a variety of clinical applications. Energy resolution [full-width at half-maximum (FWHM)] for a single element at the centre of the field of view was 4.2% at 140 keV (99mTc), and the mean energy resolution of the CdTe detector arrays was approximately 7.8%. The spatial resolution, represented by FWHM, had a mean value of 1.56 +/- 0.05 mm. Simulated node foci could be visualised clearly by the SSGC using a 15-s acquisition time. In preliminary clinical tests, the SSGC successfully imaged diseases in a variety of tissues, including salivary and thyroid glands, temporomandibular joints and sentinel lymph nodes. The SSGC has significant potential for diagnosing diseases and facilitating subsequent radioguided surgery.

Occult Breast Cancer: Scintimammography with High-Resolution Breast-specific Gamma Camera in Women at High Risk for Breast Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rachel F. Brem; Jocelyn A. Rapelyea; , Gilat Zisman

2005-08-01

To prospectively evaluate a high-resolution breast-specific gamma camera for depicting occult breast cancer in women at high risk for breast cancer but with normal mammographic and physical examination findings. MATERIALS AND METHODS: Institutional Review Board approval and informed consent were obtained. The study was HIPAA compliant. Ninety-four high-risk women (age range, 36-78 years; mean, 55 years) with normal mammographic (Breast Imaging Reporting and Data System [BI-RADS] 1 or 2) and physical examination findings were evaluated with scintimammography. After injection with 25-30 mCi (925-1110 MBq) of technetium 99m sestamibi, patients were imaged with a high-resolution small-field-of-view breast-specific gamma camera in craniocaudalmore » and mediolateral oblique projections. Scintimammograms were prospectively classified according to focal radiotracer uptake as normal (score of 1), with no focal or diffuse uptake; benign (score of 2), with minimal patchy uptake; probably benign (score of 3), with scattered patchy uptake; probably abnormal (score of 4), with mild focal radiotracer uptake; and abnormal (score of 5), with marked focal radiotracer uptake. Mammographic breast density was categorized according to BI-RADS criteria. Patients with normal scintimammograms (scores of 1, 2, or 3) were followed up for 1 year with an annual mammogram, physical examination, and repeat scintimammography. Patients with abnormal scintimammograms (scores of 4 or 5) underwent ultrasonography (US), and those with focal hypoechoic lesions underwent biopsy. If no lesion was found during US, patients were followed up with scintimammography. Specific pathologic findings were compared with scintimammographic findings. RESULTS: Of 94 women, 78 (83%) had normal scintimammograms (score of 1, 2, or 3) at initial examination and 16 (17%) had abnormal scintimammograms (score of 4 or 5). Fourteen (88%) of the 16 patients had either benign findings at biopsy or no focal abnormality at US; in two (12%) patients, invasive carcinoma was diagnosed at US-guided biopsy (9 mm each at pathologic examination). CONCLUSION: High-resolution breast-specific scintimammography can depict small (<1-cm), mammographically occult, nonpalpable lesions in women at increased risk for breast cancer not otherwise identified at mammography or physical examination.« less

Advantages of semiconductor CZT for medical imaging

NASA Astrophysics Data System (ADS)

Wagenaar, Douglas J.; Parnham, Kevin; Sundal, Bjorn; Maehlum, Gunnar; Chowdhury, Samir; Meier, Dirk; Vandehei, Thor; Szawlowski, Marek; Patt, Bradley E.

2007-09-01

Cadmium zinc telluride (CdZnTe, or CZT) is a room-temperature semiconductor radiation detector that has been developed in recent years for a variety of applications. CZT has been investigated for many potential uses in medical imaging, especially in the field of single photon emission computed tomography (SPECT). CZT can also be used in positron emission tomography (PET) as well as photon-counting and integration-mode x-ray radiography and computed tomography (CT). The principal advantages of CZT are 1) direct conversion of x-ray or gamma-ray energy into electron-hole pairs; 2) energy resolution; 3) high spatial resolution and hence high space-bandwidth product; 4) room temperature operation, stable performance, high density, and small volume; 5) depth-of-interaction (DOI) available through signal processing. These advantages will be described in detail with examples from our own CZT systems. The ability to operate at room temperature, combined with DOI and very small pixels, make the use of multiple, stationary CZT "mini-gamma cameras" a realistic alternative to today's large Anger-type cameras that require motion to obtain tomographic sampling. The compatibility of CZT with Magnetic Resonance Imaging (MRI)-fields is demonstrated for a new type of multi-modality medical imaging, namely SPECT/MRI. For pre-clinical (i.e., laboratory animal) imaging, the advantages of CZT lie in spatial and energy resolution, small volume, automated quality control, and the potential for DOI for parallax removal in pinhole imaging. For clinical imaging, the imaging of radiographically dense breasts with CZT enables scatter rejection and hence improved contrast. Examples of clinical breast images with a dual-head CZT system are shown.

Application of gamma imaging techniques for the characterisation of position sensitive gamma detectors

NASA Astrophysics Data System (ADS)

Habermann, T.; Didierjean, F.; Duchêne, G.; Filliger, M.; Gerl, J.; Kojouharov, I.; Li, G.; Pietralla, N.; Schaffner, H.; Sigward, M.-H.

2017-11-01

A device to characterize position-sensitive germanium detectors has been implemented at GSI. The main component of this so called scanning table is a gamma camera that is capable of producing online 2D images of the scanned detector by means of a PET technique. To calibrate the gamma camera Compton imaging is employed. The 2D data can be processed further offline to obtain depth information. Of main interest is the response of the scanned detector in terms of the digitized pulse shapes from the preamplifier. This is an important input for pulse-shape analysis algorithms as they are in use for gamma tracking arrays in gamma spectroscopy. To validate the scanning table, a comparison of its results with a second scanning table implemented at the IPHC Strasbourg is envisaged. For this purpose a pixelated germanium detector has been scanned.

[Evaluation of the efficacy of sentinel node detection in breast cancer: chronological course and influence of the incorporation of an intra-operative portable gamma camera].

PubMed

Goñi Gironés, E; Vicente García, F; Serra Arbeloa, P; Estébanez Estébanez, C; Calvo Benito, A; Rodrigo Rincón, I; Camarero Salazar, A; Martínez Lozano, M E

2013-01-01

To define the sentinel node identification rate in breast cancer, the chronological evolution of this parameter and the influence of the introduction of a portable gamma camera. A retrospective study was conducted using a prospective database of 754 patients who had undergone a sentinel lymph node biopsy between January 2003 and December 2011. The technique was mixed in the starting period and subsequently was performed with radiotracer intra-peritumorally administered the day before of the surgery. Until October 2009, excision of the sentinel node was guided by a probe. After that date, a portable gamma camera was introduced for intrasurgical detection. The SN was biopsied in 725 out of the 754 patients studied. The resulting technique global effectiveness was 96.2%. In accordance with the year of the surgical intervention, the identification percentage was 93.5% in 2003, 88.7% in 2004, 94.3% in 2005, 95.7% in 2006, 93.3% in 2007, 98.8% in 2008, 97.1% in 2009 and 99.1% in 2010 and 2011. There was a significant difference in the proportion of identification before and after the incorporation of the portable gamma camera of 4.6% (95% CI of the difference 2-7.2%, P = 0.0037). The percentage of global identification exceeds the recommended level following the current guidelines. Chronologically, the improvement for this parameter during the study period has been observed. These data suggest that the incorporation of a portable gamma camera had an important role. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

Review: comparison of PET rubidium-82 with conventional SPECT myocardial perfusion imaging

PubMed Central

Ghotbi, Adam A; Kjær, Andreas; Hasbak, Philip

2014-01-01

Nuclear cardiology has for many years been focused on gamma camera technology. With ever improving cameras and software applications, this modality has developed into an important assessment tool for ischaemic heart disease. However, the development of new perfusion tracers has been scarce. While cardiac positron emission tomography (PET) so far largely has been limited to centres with on-site cyclotron, recent developments with generator produced perfusion tracers such as rubidium-82, as well as an increasing number of PET scanners installed, may enable a larger patient flow that may supersede that of gamma camera myocardial perfusion imaging. PMID:24028171

The spatial resolution of a rotating gamma camera tomographic facility.

PubMed

Webb, S; Flower, M A; Ott, R J; Leach, M O; Inamdar, R

1983-12-01

An important feature determining the spatial resolution in transverse sections reconstructed by convolution and back-projection is the frequency filter corresponding to the convolution kernel. Equations have been derived giving the theoretical spatial resolution, for a perfect detector and noise-free data, using four filter functions. Experiments have shown that physical constraints will always limit the resolution that can be achieved with a given system. The experiments indicate that the region of the frequency spectrum between KN/2 and KN where KN is the Nyquist frequency does not contribute significantly to resolution. In order to investigate the physical effect of these filter functions, the spatial resolution of reconstructed images obtained with a GE 400T rotating gamma camera has been measured. The results obtained serve as an aid to choosing appropriate reconstruction filters for use with a rotating gamma camera system.

Acquisition of gamma camera and physiological data by computer.

PubMed

Hack, S N; Chang, M; Line, B R; Cooper, J A; Robeson, G H

1986-11-01

We have designed, implemented, and tested a new Research Data Acquisition System (RDAS) that permits a general purpose digital computer to acquire signals from both gamma camera sources and physiological signal sources concurrently. This system overcomes the limited multi-source, high speed data acquisition capabilities found in most clinically oriented nuclear medicine computers. The RDAS can simultaneously input signals from up to four gamma camera sources with a throughput of 200 kHz per source and from up to eight physiological signal sources with an aggregate throughput of 50 kHz. Rigorous testing has found the RDAS to exhibit acceptable linearity and timing characteristics. In addition, flood images obtained by this system were compared with flood images acquired by a commercial nuclear medicine computer system. National Electrical Manufacturers Association performance standards of the flood images were found to be comparable.

Gamma ray imager on the DIII-D tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pace, D. C., E-mail: pacedc@fusion.gat.com; Taussig, D.; Eidietis, N. W.

2016-04-15

A gamma ray camera is built for the DIII-D tokamak [J. Luxon, Nucl. Fusion 42, 614 (2002)] that provides spatial localization and energy resolution of gamma flux by combining a lead pinhole camera with custom-built detectors and optimized viewing geometry. This diagnostic system is installed on the outer midplane of the tokamak such that its 123 collimated sightlines extend across the tokamak radius while also covering most of the vertical extent of the plasma volume. A set of 30 bismuth germanate detectors can be secured in any of the available sightlines, allowing for customizable coverage in experiments with runaway electronsmore » in the energy range of 1–60 MeV. Commissioning of the gamma ray imager includes the quantification of electromagnetic noise sources in the tokamak machine hall and a measurement of the energy spectrum of background gamma radiation. First measurements of gamma rays coming from the plasma provide a suitable testbed for implementing pulse height analysis that provides the energy of detected gamma photons.« less

Gamma ray imager on the DIII-D tokamak

DOE PAGES

Pace, D. C.; Cooper, C. M.; Taussig, D.; ...

2016-04-13

A gamma ray camera is built for the DIII-D tokamak [J. Luxon, Nucl. Fusion 42, 614 (2002)] that provides spatial localization and energy resolution of gamma flux by combining a lead pinhole camera with custom-built detectors and optimized viewing geometry. This diagnostic system is installed on the outer midplane of the tokamak such that its 123 collimated sightlines extend across the tokamak radius while also covering most of the vertical extent of the plasma volume. A set of 30 bismuth germanate detectors can be secured in any of the available sightlines, allowing for customizable coverage in experiments with runaway electronsmore » in the energy range of 1- 60 MeV. Commissioning of the gamma ray imager includes the quantification of electromagnetic noise sources in the tokamak machine hall and a measurement of the energy spectrum of background gamma radiation. In conclusion, first measurements of gamma rays coming from the plasma provide a suitable testbed for implementing pulse height analysis that provides the energy of detected gamma photons.« less

Establishment of Imaging Spectroscopy of Nuclear Gamma-Rays based on Geometrical Optics.

PubMed

Tanimori, Toru; Mizumura, Yoshitaka; Takada, Atsushi; Miyamoto, Shohei; Takemura, Taito; Kishimoto, Tetsuro; Komura, Shotaro; Kubo, Hidetoshi; Kurosawa, Shunsuke; Matsuoka, Yoshihiro; Miuchi, Kentaro; Mizumoto, Tetsuya; Nakamasu, Yuma; Nakamura, Kiseki; Parker, Joseph D; Sawano, Tatsuya; Sonoda, Shinya; Tomono, Dai; Yoshikawa, Kei

2017-02-03

Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain quantitative imaging, cameras that realize geometrical optics is essential, which would be, for nuclear MeV gammas, only possible via complete reconstruction of the Compton process. Recently we have revealed that "Electron Tracking Compton Camera" (ETCC) provides a well-defined Point Spread Function (PSF). The information of an incoming gamma is kept along a ray with the PSF and that is equivalent to geometrical optics. Here we present an imaging-spectroscopic measurement with the ETCC. Our results highlight the intrinsic difficulty with CCs in performing accurate imaging, and show that the ETCC surmounts this problem. The imaging capability also helps the ETCC suppress the noise level dramatically by ~3 orders of magnitude without a shielding structure. Furthermore, full reconstruction of Compton process with the ETCC provides spectra free of Compton edges. These results mark the first proper imaging of nuclear gammas based on the genuine geometrical optics.

A didactic experiment showing the Compton scattering by means of a clinical gamma camera.

PubMed

Amato, Ernesto; Auditore, Lucrezia; Campennì, Alfredo; Minutoli, Fabio; Cucinotta, Mariapaola; Sindoni, Alessandro; Baldari, Sergio

2017-06-01

We describe a didactic approach aimed to explain the effect of Compton scattering in nuclear medicine imaging, exploiting the comparison of a didactic experiment with a gamma camera with the outcomes from a Monte Carlo simulation of the same experimental apparatus. We employed a 99m Tc source emitting 140.5keV photons, collimated in the upper direction through two pinholes, shielded by 6mm of lead. An aluminium cylinder was placed on the source at 50mm of distance. The energy of the scattered photons was measured on the spectra acquired by the gamma camera. We observed that the gamma ray energy measured at each step of rotation gradually decreased from the characteristic energy of 140.5keV at 0° to 102.5keV at 120°. A comparison between the obtained data and the expected results from the Compton formula and from the Monte Carlo simulation revealed a full agreement within the experimental error (relative errors between -0.56% and 1.19%), given by the energy resolution of the gamma camera. Also the electron rest mass has been evaluated satisfactorily. The experiment was found useful in explaining nuclear medicine residents the phenomenology of the Compton scattering and its importance in the nuclear medicine imaging, and it can be profitably proposed during the training of medical physics residents as well. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Psychophysical Calibration of Mobile Touch-Screens for Vision Testing in the Field

NASA Technical Reports Server (NTRS)

Mulligan, Jeffrey B.

2015-01-01

The now ubiquitous nature of touch-screen displays in cell phones and tablet computers makes them an attractive option for vision testing outside of the laboratory or clinic. Accurate measurement of parameters such as contrast sensitivity, however, requires precise control of absolute and relative screen luminances. The nonlinearity of the display response (gamma) can be measured or checked using a minimum motion technique similar to that developed by Anstis and Cavanagh (1983) for the determination of isoluminance. While the relative luminances of the color primaries vary between subjects (due to factors such as individual differences in pre-retinal pigment densities), the gamma nonlinearity can be checked in the lab using a photometer. Here we compare results obtained using the psychophysical method with physical measurements for a number of different devices. In addition, we present a novel physical method using the device's built-in front-facing camera in conjunction with a mirror to jointly calibrate the camera and display. A high degree of consistency between devices is found, but some departures from ideal performance are observed. In spite of this, the effects of calibration errors and display artifacts on estimates of contrast sensitivity are found to be small.

The Rapidly Moving Telescope: an Instrument for the Precise Study of Optical Transients

NASA Technical Reports Server (NTRS)

Teegarden, B. J.; Vonrosenvinge, T. T.; Cline, T. L.; Kaipa, R.

1983-01-01

The development of a small telescope with a very rapid pointing capability is described whose purpose is to search for and study fast optical transients that may be associated with gamma-ray bursts and other phenomena. The primary motivation for this search is the discovery of the existence of a transient optical event from the known location of a gamma-ray bursts. The telescope has the capability of rapidly acquiring any target in the night sky within 0.7 second and locating the object's position with + or - 1 arcsec accuracy. The initial detection of the event is accomplished by the MIT explosive transient camera or ETC. This provides rough pointing coordinates to the RMT on the average within approximately 1 second after the detection of the event.

Evaluation of Origin Ensemble algorithm for image reconstruction for pixelated solid-state detectors with large number of channels

NASA Astrophysics Data System (ADS)

Kolstein, M.; De Lorenzo, G.; Mikhaylova, E.; Chmeissani, M.; Ariño, G.; Calderón, Y.; Ozsahin, I.; Uzun, D.

2013-04-01

The Voxel Imaging PET (VIP) Pathfinder project intends to show the advantages of using pixelated solid-state technology for nuclear medicine applications. It proposes designs for Positron Emission Tomography (PET), Positron Emission Mammography (PEM) and Compton gamma camera detectors with a large number of signal channels (of the order of 106). For PET scanners, conventional algorithms like Filtered Back-Projection (FBP) and Ordered Subset Expectation Maximization (OSEM) are straightforward to use and give good results. However, FBP presents difficulties for detectors with limited angular coverage like PEM and Compton gamma cameras, whereas OSEM has an impractically large time and memory consumption for a Compton gamma camera with a large number of channels. In this article, the Origin Ensemble (OE) algorithm is evaluated as an alternative algorithm for image reconstruction. Monte Carlo simulations of the PET design are used to compare the performance of OE, FBP and OSEM in terms of the bias, variance and average mean squared error (MSE) image quality metrics. For the PEM and Compton camera designs, results obtained with OE are presented.

Performance Test Data Analysis of Scintillation Cameras

NASA Astrophysics Data System (ADS)

Demirkaya, Omer; Mazrou, Refaat Al

2007-10-01

In this paper, we present a set of image analysis tools to calculate the performance parameters of gamma camera systems from test data acquired according to the National Electrical Manufacturers Association NU 1-2001 guidelines. The calculation methods are either completely automated or require minimal user interaction; minimizing potential human errors. The developed methods are robust with respect to varying conditions under which these tests may be performed. The core algorithms have been validated for accuracy. They have been extensively tested on images acquired by the gamma cameras from different vendors. All the algorithms are incorporated into a graphical user interface that provides a convenient way to process the data and report the results. The entire application has been developed in MATLAB programming environment and is compiled to run as a stand-alone program. The developed image analysis tools provide an automated, convenient and accurate means to calculate the performance parameters of gamma cameras and SPECT systems. The developed application is available upon request for personal or non-commercial uses. The results of this study have been partially presented in Society of Nuclear Medicine Annual meeting as an InfoSNM presentation.

Assessment of right ventricular function with nonimaging first pass ventriculography and comparison of results with gamma camera studies.

PubMed

Zhang, Z; Liu, X J; Liu, Y Z; Lu, P; Crawley, J C; Lahiri, A

1990-08-01

A new technique has been developed for measuring right ventricular function by nonimaging first pass ventriculography. The right ventricular ejection fraction (RVEF) obtained by non-imaging first pass ventriculography was compared with that obtained by gamma camera first pass and equilibrium ventriculography. The data has demonstrated that the correlation of RVEFs obtained by the nonimaging nuclear cardiac probe and by gamma camera first pass ventriculography in 15 subjects was comparable (r = 0.93). There was also a good correlation between RVEFs obtained by the nonimaging nuclear probe and by equilibrium gated blood pool studies in 33 subjects (r = 0.89). RVEF was significantly reduced in 15 patients with right ventricular and/or inferior myocardial infarction compared to normal subjects (28 +/- 9% v. 45 +/- 9%). The data suggests that nonimaging probes may be used for assessing right ventricular function accurately.

Emission computerized axial tomography from multiple gamma-camera views using frequency filtering.

PubMed

Pelletier, J L; Milan, C; Touzery, C; Coitoux, P; Gailliard, P; Budinger, T F

1980-01-01

Emission computerized axial tomography is achievable in any nuclear medicine department from multiple gamma camera views. Data are collected by rotating the patient in front of the camera. A simple fast algorithm is implemented, known as the convolution technique: first the projection data are Fourier transformed and then an original filter designed for optimizing resolution and noise suppression is applied; finally the inverse transform of the latter operation is back-projected. This program, which can also take into account the attenuation for single photon events, was executed with good results on phantoms and patients. We think that it can be easily implemented for specific diagnostic problems.

The Advanced Gamma-ray Imaging System (AGIS) - Camera Electronics Development

NASA Astrophysics Data System (ADS)

Tajima, Hiroyasu; Bechtol, K.; Buehler, R.; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Hanna, D.; Horan, D.; Humensky, B.; Karlsson, N.; Kieda, D.; Konopelko, A.; Krawczynski, H.; Krennrich, F.; Mukherjee, R.; Ong, R.; Otte, N.; Quinn, J.; Schroedter, M.; Swordy, S.; Wagner, R.; Wakely, S.; Weinstein, A.; Williams, D.; Camera Working Group; AGIS Collaboration

2010-03-01

AGIS, a next-generation imaging atmospheric Cherenkov telescope (IACT) array, aims to achieve a sensitivity level of about one milliCrab for gamma-ray observations in the energy band of 50 GeV to 100 TeV. Achieving this level of performance will require on the order of 50 telescopes with perhaps as many as 1M total electronics channels. The larger scale of AGIS requires a very different approach from the currently operating IACTs, with lower-cost and lower-power electronics incorporated into camera modules designed for high reliability and easy maintenance. Here we present the concept and development status of the AGIS camera electronics.

Camera Development for the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Moncada, Roberto Jose

2017-01-01

With the Cherenkov Telescope Array (CTA), the very-high-energy gamma-ray universe, between 30 GeV and 300 TeV, will be probed at an unprecedented resolution, allowing deeper studies of known gamma-ray emitters and the possible discovery of new ones. This exciting project could also confirm the particle nature of dark matter by looking for the gamma rays produced by self-annihilating weakly interacting massive particles (WIMPs). The telescopes will use the imaging atmospheric Cherenkov technique (IACT) to record Cherenkov photons that are produced by the gamma-ray induced extensive air shower. One telescope design features dual-mirror Schwarzschild-Couder (SC) optics that allows the light to be finely focused on the high-resolution silicon photomultipliers of the camera modules starting from a 9.5-meter primary mirror. Each camera module will consist of a focal plane module and front-end electronics, and will have four TeV Array Readout with GSa/s Sampling and Event Trigger (TARGET) chips, giving them 64 parallel input channels. The TARGET chip has a self-trigger functionality for readout that can be used in higher logic across camera modules as well as across individual telescopes, which will each have 177 camera modules. There will be two sites, one in the northern and the other in the southern hemisphere, for full sky coverage, each spanning at least one square kilometer. A prototype SC telescope is currently under construction at the Fred Lawrence Whipple Observatory in Arizona. This work was supported by the National Science Foundation's REU program through NSF award AST-1560016.

Sentinel node detection in early breast cancer with intraoperative portable gamma camera: UK experience.

PubMed

Ghosh, Debashis; Michalopoulos, Nikolaos V; Davidson, Timothy; Wickham, Fred; Williams, Norman R; Keshtgar, Mohammed R

2017-04-01

Access to nuclear medicine department for sentinel node imaging remains an issue in number of hospitals in the UK and many parts of the world. Sentinella ® is a portable imaging camera used intra-operatively to produce real time visual localisation of sentinel lymph nodes. Sentinella ® was tested in a controlled laboratory environment at our centre and we report our experience on the first use of this technology from UK. Moreover, preoperative scintigrams of the axilla were obtained in 144 patients undergoing sentinel node biopsy using conventional gamma camera. Sentinella ® scans were done intra-operatively to correlate with the pre-operative scintigram and to determine presence of any residual hot node after the axilla was deemed to be clear based on the silence of the hand held gamma probe. Sentinella ® detected significantly more nodes compared with CGC (p < 0.0001). Sentinella ® picked up extra nodes in 5/144 cases after the axilla was found silent using hand held gamma probe. In 2/144 cases, extra nodes detected by Sentinella ® confirmed presence of tumour cells that led to a complete axillary clearance. Sentinella ® is a reliable technique for intra-operative localisation of radioactive nodes. It provides increased nodal visualisation rates compared to static scintigram imaging and proves to be an important tool for harvesting all hot sentinel nodes. This portable gamma camera can definitely replace the use of conventional lymphoscintigrams saving time and money both for patients and the health system. Copyright © 2016 Elsevier Ltd. All rights reserved.

Improved scintimammography using a high-resolution camera mounted on an upright mammography gantry

NASA Astrophysics Data System (ADS)

Itti, Emmanuel; Patt, Bradley E.; Diggles, Linda E.; MacDonald, Lawrence; Iwanczyk, Jan S.; Mishkin, Fred S.; Khalkhali, Iraj

2003-01-01

99mTc-sestamibi scintimammography (SMM) is a useful adjunct to conventional X-ray mammography (XMM) for the assessment of breast cancer. An increasing number of studies has emphasized fair sensitivity values for the detection of tumors >1 cm, compared to XMM, particularly in situations where high glandular breast densities make mammographic interpretation difficult. In addition, SMM has demonstrated high specificity for cancer, compared to various functional and anatomic imaging modalities. However, large field-of-view (FOV) gamma cameras are difficult to position close to the breasts, which decreases spatial resolution and subsequently, the sensitivity of detection for tumors <1 cm. New dedicated detectors featuring small FOV and increased spatial resolution have recently been developed. In this setting, improvement in tumor detection sensitivity, particularly with regard to small cancers is expected. At Division of Nuclear Medicine, Harbor-UCLA Medical Center, we have performed over 2000 SMM within the last 9 years. We have recently used a dedicated breast camera (LumaGEM™) featuring a 12.8×12.8 cm 2 FOV and an array of 2×2×6 mm 3 discrete crystals coupled to a photon-sensitive photomultiplier tube readout. This camera is mounted on a mammography gantry allowing upright imaging, medial positioning and use of breast compression. Preliminary data indicates significant enhancement of spatial resolution by comparison with standard imaging in the first 10 patients. Larger series will be needed to conclude on sensitivity/specificity issues.

SeHCAT retention values as measured with a collimated and an uncollimated gamma camera: a method comparison study.

PubMed

Wright, James W; Lovell, Lesley A; Gemmell, Howard G; McKiddie, Fergus; Staff, Roger T

2013-07-01

TauroH-23-(Se) selena-25-homocholic acid retention values are used in the diagnosis of bile acid malabsorption. The standard method for measuring values is with an uncollimated gamma camera, which can create some logistic difficulties, with other background sources of activity, which are irrelevant when a collimator is used, becoming significant. In this study we compare the retention values obtained with a collimated and an uncollimated gamma camera in phantoms and in 23 patients. Bland-Altman plots were created using the data, which showed a mean bias in retention of 0.10% in the phantom study and 0.55% in the patient study between methods. A Wilcoxon signed-rank test with the null hypothesis of zero median difference between uncollimated and collimated methods was not statistically significant to P values less than 0.05 in the patient and phantom studies. In the patient study, on using a fixed boundary of retention (10%) between positive and negative status, the status of one patient was changed from negative (12%) to positive (9%). We conclude that measurement of retention with a collimated gamma camera is similar but not identical to that of uncollimated values. The clinical significance of this shift is unclear, as the threshold of significance and the method of integrating this measure with other clinical factors into management remain unclear.

Gallbladder radionuclide scan (image)

MedlinePlus

... gallbladder radionuclide scan is performed by injecting a tracer (radioactive chemical) into the bloodstream. A gamma camera ... detect the gamma rays being emitted from the tracer, and the image of where the tracer is ...

Clinical trials of the prototype Rutherford Appleton Laboratory MWPC positron camera at the Royal Marsden Hospital

NASA Astrophysics Data System (ADS)

Flower, M. A.; Ott, R. J.; Webb, S.; Leach, M. O.; Marsden, P. K.; Clack, R.; Khan, O.; Batty, V.; McCready, V. R.; Bateman, J. E.

1988-06-01

Two clinical trials of the prototype RAL multiwire proportional chamber (MWPC) positron camera were carried out prior to the development of a clinical system with large-area detectors. During the first clinical trial, the patient studies included skeletal imaging using 18F, imaging of brain glucose metabolism using 18F FDG, bone marrow imaging using 52Fe citrate and thyroid imaging with Na 124I. Longitudinal tomograms were produced from the limited-angle data acquisition from the static detectors. During the second clinical trial, transaxial, coronal and sagittal images were produced from the multiview data acquisition. A more detailed thyroid study was performed in which the volume of the functioning thyroid tissue was obtained from the 3D PET image and this volume was used in estimating the radiation dose achieved during radioiodine therapy of patients with thyrotoxicosis. Despite the small field of view of the prototype camera, and the use of smaller than usual amounts of activity administered, the PET images were in most cases comparable with, and in a few cases visually better than, the equivalent planar view using a state-of-the-art gamma camera with a large field of view and routine radiopharmaceuticals.

"Stereo Compton cameras" for the 3-D localization of radioisotopes

NASA Astrophysics Data System (ADS)

Takeuchi, K.; Kataoka, J.; Nishiyama, T.; Fujita, T.; Kishimoto, A.; Ohsuka, S.; Nakamura, S.; Adachi, S.; Hirayanagi, M.; Uchiyama, T.; Ishikawa, Y.; Kato, T.

2014-11-01

The Compton camera is a viable and convenient tool used to visualize the distribution of radioactive isotopes that emit gamma rays. After the nuclear disaster in Fukushima in 2011, there is a particularly urgent need to develop "gamma cameras", which can visualize the distribution of such radioisotopes. In response, we propose a portable Compton camera, which comprises 3-D position-sensitive GAGG scintillators coupled with thin monolithic MPPC arrays. The pulse-height ratio of two MPPC-arrays allocated at both ends of the scintillator block determines the depth of interaction (DOI), which dramatically improves the position resolution of the scintillation detectors. We report on the detailed optimization of the detector design, based on Geant4 simulation. The results indicate that detection efficiency reaches up to 0.54%, or more than 10 times that of other cameras being tested in Fukushima, along with a moderate angular resolution of 8.1° (FWHM). By applying the triangular surveying method, we also propose a new concept for the stereo measurement of gamma rays by using two Compton cameras, thus enabling the 3-D positional measurement of radioactive isotopes for the first time. From one point source simulation data, we ensured that the source position and the distance to the same could be determined typically to within 2 meters' accuracy and we also confirmed that more than two sources are clearly separated by the event selection from two point sources of simulation data.

Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM).

PubMed

Agostini, Denis; Marie, Pierre-Yves; Ben-Haim, Simona; Rouzet, François; Songy, Bernard; Giordano, Alessandro; Gimelli, Alessia; Hyafil, Fabien; Sciagrà, Roberto; Bucerius, Jan; Verberne, Hein J; Slart, Riemer H J A; Lindner, Oliver; Übleis, Christopher; Hacker, Marcus

2016-12-01

The trade-off between resolution and count sensitivity dominates the performance of standard gamma cameras and dictates the need for relatively high doses of radioactivity of the used radiopharmaceuticals in order to limit image acquisition duration. The introduction of cadmium-zinc-telluride (CZT)-based cameras may overcome some of the limitations against conventional gamma cameras. CZT cameras used for the evaluation of myocardial perfusion have been shown to have a higher count sensitivity compared to conventional single photon emission computed tomography (SPECT) techniques. CZT image quality is further improved by the development of a dedicated three-dimensional iterative reconstruction algorithm, based on maximum likelihood expectation maximization (MLEM), which corrects for the loss in spatial resolution due to line response function of the collimator. All these innovations significantly reduce imaging time and result in a lower patient's radiation exposure compared with standard SPECT. To guide current and possible future users of the CZT technique for myocardial perfusion imaging, the Cardiovascular Committee of the European Association of Nuclear Medicine, starting from the experience of its members, has decided to examine the current literature regarding procedures and clinical data on CZT cameras. The committee hereby aims 1) to identify the main acquisitions protocols; 2) to evaluate the diagnostic and prognostic value of CZT derived myocardial perfusion, and finally 3) to determine the impact of CZT on radiation exposure.

The added value of a portable gamma camera for intraoperative detection of sentinel lymph node in squamous cell carcinoma of the oral cavity: A case report.

PubMed

Mayoral, M; Paredes, P; Sieira, R; Vidal-Sicart, S; Marti, C; Pons, F

2014-01-01

The use of sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity is still subject to debate although some studies have reported its feasibility. The main reason for this debate is probably due to the high false-negative rate for floor-of-mouth tumors per se. We report the case of a 54-year-old man with a T1N0 floor-of-mouth squamous cell carcinoma who underwent the sentinel lymph node procedure. Lymphoscintigraphy and SPECT/CT imaging were performed for lymphatic mapping with a conventional gamma camera. Sentinel lymph nodes were identified at right Ib, left IIa and Ia levels. However, these sentinel lymph nodes were difficult to detect intraoperatively with a gamma probe owing to the activity originating from the injection site. The use of a portable gamma camera made it possible to localize and excise all the sentinel lymph nodes. This case demonstrates the usefulness of this tool to improve sentinel lymph node detecting in floor-of-mouth tumors, especially those close to the injection area. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

Experimental comparison of high-density scintillators for EMCCD-based gamma ray imaging

NASA Astrophysics Data System (ADS)

Heemskerk, Jan W. T.; Kreuger, Rob; Goorden, Marlies C.; Korevaar, Marc A. N.; Salvador, Samuel; Seeley, Zachary M.; Cherepy, Nerine J.; van der Kolk, Erik; Payne, Stephen A.; Dorenbos, Pieter; Beekman, Freek J.

2012-07-01

Detection of x-rays and gamma rays with high spatial resolution can be achieved with scintillators that are optically coupled to electron-multiplying charge-coupled devices (EMCCDs). These can be operated at typical frame rates of 50 Hz with low noise. In such a set-up, scintillation light within each frame is integrated after which the frame is analyzed for the presence of scintillation events. This method allows for the use of scintillator materials with relatively long decay times of a few milliseconds, not previously considered for use in photon-counting gamma cameras, opening up an unexplored range of dense scintillators. In this paper, we test CdWO4 and transparent polycrystalline ceramics of Lu2O3:Eu and (Gd,Lu)2O3:Eu as alternatives to currently used CsI:Tl in order to improve the performance of EMCCD-based gamma cameras. The tested scintillators were selected for their significantly larger cross-sections at 140 keV (99mTc) compared to CsI:Tl combined with moderate to good light yield. A performance comparison based on gamma camera spatial and energy resolution was done with all tested scintillators having equal (66%) interaction probability at 140 keV. CdWO4, Lu2O3:Eu and (Gd,Lu)2O3:Eu all result in a significantly improved spatial resolution over CsI:Tl, albeit at the cost of reduced energy resolution. Lu2O3:Eu transparent ceramic gives the best spatial resolution: 65 µm full-width-at-half-maximum (FWHM) compared to 147 µm FWHM for CsI:Tl. In conclusion, these ‘slow’ dense scintillators open up new possibilities for improving the spatial resolution of EMCCD-based scintillation cameras.

Estimation of bone mineral content using gamma camera: A real possibility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levy, L.M.; Hoory, S.; Bandyopadhyay, D.

1985-05-01

Osteopenia and Osteoporosis are the diseases related to loss of bone minerals. At present, dual photon absorptiometry using a dedicated specially built scanner along with a very high source of Gd-153 is being used as a diagnostic tool for the early detection of bone loss. The present study was undertaken to explore the possibility that gamma cameras which are widely available in all Nuclear Medicine departments could be used successfully to evaluate bone mineral content. A Siemens LFOV gamma camera equipped with a converging collimator was used for this purpose. A fixed source (100 mCi) of Gd-153 was placed atmore » the focal point of the collimator. A series of calcium chloride solutions of varying concentrations in plastic vials were placed near the center of the collimator and imaged both in air and water. Both 44 Kev and 100 Kev images were digitized in 128 x 128 matrices and processed in a CD and A Delta system attached to a VAX 11-750 computer. Uniformity corrections for each field of view were applied and the attenuation coefficients of calcium chloride for both peaks of Gd-153 were evaluated. In addition, due to the high count rate, corrections for the dead time losses were also found to be essential. An excellent concordance between the estimated Calcium contents and that actually present were obtained by this technic. In conclusion, use of gamma camera for the routine evaluation of Osteoporosis appears to be highly promising and worth pursuing.« less

Fast Pb-glass neutron-to-light converter for ICF (Inertial Confinement Fusion) target burn history measurements

NASA Astrophysics Data System (ADS)

Lerche, R. A.; Cable, M. D.; Phillion, D. W.

1990-09-01

We are developing a streak camera based instrument to diagnose the fusion reaction rate (burn history) within laser-driven ICF targets filled with D-T fuel. Recently, we attempted measurements using the 16.7 MeV gamma ray emitted in the T(d,gamma)He(5) fusion reaction. Pb glass which has a large cross section for pair production acts as a gamma-ray-to-light converter. Gamma rays interact within the glass to form electron-positron pairs that produce large amounts (1000 photons/gamma ray) of prompt (less than 10 ps) Cerenkov light as they slow down. In our experimental instrument, an f/10 Cassegrain telescope optically couples light produced within the converter to a streak camera having 20-ps resolution. Experiments using high-yield (10(exp 13) D-T neutrons), direct-drive targets at Nova produced good signals with widths of 200 ps. Time-of-flight measurements show the signals to be induced by neutrons rather than gamma rays. The Pb glass appears to act as a fast neutron-to-light converter. We continue to study the interactions process and the possibility of using the 16.7 MeV gamma rays for burn time measurements.

3D tomographic imaging with the γ-eye planar scintigraphic gamma camera

NASA Astrophysics Data System (ADS)

Tunnicliffe, H.; Georgiou, M.; Loudos, G. K.; Simcox, A.; Tsoumpas, C.

2017-11-01

γ-eye is a desktop planar scintigraphic gamma camera (100 mm × 50 mm field of view) designed by BET Solutions as an affordable tool for dynamic, whole body, small-animal imaging. This investigation tests the viability of using γ-eye for the collection of tomographic data for 3D SPECT reconstruction. Two software packages, QSPECT and STIR (software for tomographic image reconstruction), have been compared. Reconstructions have been performed using QSPECT’s implementation of the OSEM algorithm and STIR’s OSMAPOSL (Ordered Subset Maximum A Posteriori One Step Late) and OSSPS (Ordered Subsets Separable Paraboloidal Surrogate) algorithms. Reconstructed images of phantom and mouse data have been assessed in terms of spatial resolution, sensitivity to varying activity levels and uniformity. The effect of varying the number of iterations, the voxel size (1.25 mm default voxel size reduced to 0.625 mm and 0.3125 mm), the point spread function correction and the weight of prior terms were explored. While QSPECT demonstrated faster reconstructions, STIR outperformed it in terms of resolution (as low as 1 mm versus 3 mm), particularly when smaller voxel sizes were used, and in terms of uniformity, particularly when prior terms were used. Little difference in terms of sensitivity was seen throughout.

Applications of iQID cameras

NASA Astrophysics Data System (ADS)

Han, Ling; Miller, Brian W.; Barrett, Harrison H.; Barber, H. Bradford; Furenlid, Lars R.

2017-09-01

iQID is an intensified quantum imaging detector developed in the Center for Gamma-Ray Imaging (CGRI). Originally called BazookaSPECT, iQID was designed for high-resolution gamma-ray imaging and preclinical gamma-ray single-photon emission computed tomography (SPECT). With the use of a columnar scintillator, an image intensifier and modern CCD/CMOS sensors, iQID cameras features outstanding intrinsic spatial resolution. In recent years, many advances have been achieved that greatly boost the performance of iQID, broadening its applications to cover nuclear and particle imaging for preclinical, clinical and homeland security settings. This paper presents an overview of the recent advances of iQID technology and its applications in preclinical and clinical scintigraphy, preclinical SPECT, particle imaging (alpha, neutron, beta, and fission fragment), and digital autoradiography.

Characterization of a high-purity germanium detector for small-animal SPECT

PubMed Central

Johnson, Lindsay C; Campbell, Desmond L; Hull, Ethan L; Peterson, Todd E

2011-01-01

We present an initial evaluation of a mechanically-cooled, high-purity germanium double-sided strip detector as a potential gamma camera for small-animal SPECT. It is 90 mm in diameter and 10 mm thick with two sets of 16 orthogonal strips that have a 4.5 mm width with a 5 mm pitch. We found an energy resolution of 0.96% at 140 keV, an intrinsic efficiency of 43.3% at 122 keV and a FWHM spatial resolution of approximately 1.5 mm. We demonstrated depth-of-interaction estimation capability through comparison of pinhole acquisitions with a point source on and off axis. Finally, a flood-corrected-flood image exhibited a strip-level uniformity of less than 1%. This high-purity germanium offers many desirable properties for small-animal SPECT. PMID:21852723

Characterization of a high-purity germanium detector for small-animal SPECT.

PubMed

Johnson, Lindsay C; Campbell, Desmond L; Hull, Ethan L; Peterson, Todd E

2011-09-21

We present an initial evaluation of a mechanically cooled, high-purity germanium double-sided strip detector as a potential gamma camera for small-animal SPECT. It is 90 mm in diameter and 10 mm thick with two sets of 16 orthogonal strips that have a 4.5 mm width with a 5 mm pitch. We found an energy resolution of 0.96% at 140 keV, an intrinsic efficiency of 43.3% at 122 keV and a FWHM spatial resolution of approximately 1.5 mm. We demonstrated depth-of-interaction estimation capability through comparison of pinhole acquisitions with a point source on and off axes. Finally, a flood-corrected flood image exhibited a strip-level uniformity of less than 1%. This high-purity germanium offers many desirable properties for small-animal SPECT.

Brain single-photon emission CT physics principles.

PubMed

Accorsi, R

2008-08-01

The basic principles of scintigraphy are reviewed and extended to 3D imaging. Single-photon emission computed tomography (SPECT) is a sensitive and specific 3D technique to monitor in vivo functional processes in both clinical and preclinical studies. SPECT/CT systems are becoming increasingly common and can provide accurately registered anatomic information as well. In general, SPECT is affected by low photon-collection efficiency, but in brain imaging, not all of the large FOV of clinical gamma cameras is needed: The use of fan- and cone-beam collimation trades off the unused FOV for increased sensitivity and resolution. The design of dedicated cameras aims at increased angular coverage and resolution by minimizing the distance from the patient. The corrections needed for quantitative imaging are challenging but can take advantage of the relative spatial uniformity of attenuation and scatter. Preclinical systems can provide submillimeter resolution in small animal brain imaging with workable sensitivity.

A fast algorithm for computer aided collimation gamma camera (CACAO)

NASA Astrophysics Data System (ADS)

Jeanguillaume, C.; Begot, S.; Quartuccio, M.; Douiri, A.; Franck, D.; Pihet, P.; Ballongue, P.

2000-08-01

The computer aided collimation gamma camera is aimed at breaking down the resolution sensitivity trade-off of the conventional parallel hole collimator. It uses larger and longer holes, having an added linear movement at the acquisition sequence. A dedicated algorithm including shift and sum, deconvolution, parabolic filtering and rotation is described. Examples of reconstruction are given. This work shows that a simple and fast algorithm, based on a diagonal dominant approximation of the problem can be derived. Its gives a practical solution to the CACAO reconstruction problem.

The Si/CdTe semiconductor Compton camera of the ASTRO-H Soft Gamma-ray Detector (SGD)

NASA Astrophysics Data System (ADS)

Watanabe, Shin; Tajima, Hiroyasu; Fukazawa, Yasushi; Ichinohe, Yuto; Takeda, Shin`ichiro; Enoto, Teruaki; Fukuyama, Taro; Furui, Shunya; Genba, Kei; Hagino, Kouichi; Harayama, Atsushi; Kuroda, Yoshikatsu; Matsuura, Daisuke; Nakamura, Ryo; Nakazawa, Kazuhiro; Noda, Hirofumi; Odaka, Hirokazu; Ohta, Masayuki; Onishi, Mitsunobu; Saito, Shinya; Sato, Goro; Sato, Tamotsu; Takahashi, Tadayuki; Tanaka, Takaaki; Togo, Atsushi; Tomizuka, Shinji

2014-11-01

The Soft Gamma-ray Detector (SGD) is one of the instrument payloads onboard ASTRO-H, and will cover a wide energy band (60-600 keV) at a background level 10 times better than instruments currently in orbit. The SGD achieves low background by combining a Compton camera scheme with a narrow field-of-view active shield. The Compton camera in the SGD is realized as a hybrid semiconductor detector system which consists of silicon and cadmium telluride (CdTe) sensors. The design of the SGD Compton camera has been finalized and the final prototype, which has the same configuration as the flight model, has been fabricated for performance evaluation. The Compton camera has overall dimensions of 12 cm×12 cm×12 cm, consisting of 32 layers of Si pixel sensors and 8 layers of CdTe pixel sensors surrounded by 2 layers of CdTe pixel sensors. The detection efficiency of the Compton camera reaches about 15% and 3% for 100 keV and 511 keV gamma rays, respectively. The pixel pitch of the Si and CdTe sensors is 3.2 mm, and the signals from all 13,312 pixels are processed by 208 ASICs developed for the SGD. Good energy resolution is afforded by semiconductor sensors and low noise ASICs, and the obtained energy resolutions with the prototype Si and CdTe pixel sensors are 1.0-2.0 keV (FWHM) at 60 keV and 1.6-2.5 keV (FWHM) at 122 keV, respectively. This results in good background rejection capability due to better constraints on Compton kinematics. Compton camera energy resolutions achieved with the final prototype are 6.3 keV (FWHM) at 356 keV and 10.5 keV (FWHM) at 662 keV, which satisfy the instrument requirements for the SGD Compton camera (better than 2%). Moreover, a low intrinsic background has been confirmed by the background measurement with the final prototype.

SHOK—The First Russian Wide-Field Optical Camera in Space

NASA Astrophysics Data System (ADS)

Lipunov, V. M.; Gorbovskoy, E. S.; Kornilov, V. G.; Panasyuk, M. I.; Amelushkin, A. M.; Petrov, V. L.; Yashin, I. V.; Svertilov, S. I.; Vedenkin, N. N.

2018-02-01

Onboard the spacecraft Lomonosov is established two fast, fixed, very wide-field cameras SHOK. The main goal of this experiment is the observation of GRB optical emission before, synchronously, and after the gamma-ray emission. The field of view of each of the cameras is placed in the gamma-ray burst detection area of other devices located onboard the "Lomonosov" spacecraft. SHOK provides measurements of optical emissions with a magnitude limit of ˜ 9-10m on a single frame with an exposure of 0.2 seconds. The device is designed for continuous sky monitoring at optical wavelengths in the very wide field of view (1000 square degrees each camera), detection and localization of fast time-varying (transient) optical sources on the celestial sphere, including provisional and synchronous time recording of optical emissions from the gamma-ray burst error boxes, detected by the BDRG device and implemented by a control signal (alert trigger) from the BDRG. The Lomonosov spacecraft has two identical devices, SHOK1 and SHOK2. The core of each SHOK device is a fast-speed 11-Megapixel CCD. Each of the SHOK devices represents a monoblock, consisting of a node observations of optical emission, the electronics node, elements of the mechanical construction, and the body.

PRODUCTION OF RADIOACTIVE IODINE.

DOE Office of Scientific and Technical Information (OSTI.GOV)

SCHLYER,D.J.

2001-08-08

Probably the most widely used cyclotron produced radiohalogen is I-123. It has gradually replaced I-131 as the isotope of choice for diagnostic radiopharmaceuticals containing radioiodine. It gives a much lower radiation dose to the patient and the gamma ray energy of 159 keV is ideally suited for use in a gamma camera. The gamma ray will penetrate tissue very effectively without excessive radiation dose. For this reason, it has in many instances replaced the reactor produced iodine-131 (Lambrecht and Wolf 1973). A great number of radiopharmaceuticals have been labeled using I-123 and the number is increasing. One of the mostmore » promising uses of I-123 is in the imaging of monoclonal antibodies to localize and visualize tumors. However, preclinical and clinical experiences with radiolabeled antibodies have not realized the expectations regarding specificity and sensitivity of tumor localization with these agents. It appears that much of the administered activity is not associated with the tumor site and only a small fraction actually accumulates there. Work continues in this area and tumor-associated antigens can be targets for specific antibody reagents.« less

Europe's space camera unmasks a cosmic gamma-ray machine

NASA Astrophysics Data System (ADS)

1996-11-01

The new-found neutron star is the visible counterpart of a pulsating radio source, Pulsar 1055-52. It is a mere 20 kilometres wide. Although the neutron star is very hot, at about a million degrees C, very little of its radiant energy takes the form of visible light. It emits mainly gamma-rays, an extremely energetic form of radiation. By examining it at visible wavelengths, astronomers hope to figure out why Pulsar 1055-52 is the most efficient generator of gamma-rays known so far, anywhere the Universe. The Faint Object Camera found Pulsar 1055-52 in near ultraviolet light at 3400 angstroms, a little shorter in wavelength than the violet light at the extremity of the human visual range. Roberto Mignani, Patrizia Caraveo and Giovanni Bignami of the Istituto di Fisica Cosmica in Milan, Italy, report its optical identification in a forthcoming issue of Astrophysical Journal Letters (1 January 1997). The formal name of the object is PSR 1055-52. Evading the glare of an adjacent star The Italian team had tried since 1988 to spot Pulsar 1055-52 with two of the most powerful ground-based optical telescopes in the Southern Hemisphere. These were the 3.6-metre Telescope and the 3.5-metre New Technology Telescope of the European Southern Observatory at La Silla, Chile. Unfortunately an ordinary star 100,000 times brighter lay in almost the same direction in the sky, separated from the neutron star by only a thousandth of a degree. The Earth's atmosphere defocused the star's light sufficiently to mask the glimmer from Pulsar 1055-52. The astronomers therefore needed an instrument in space. The Faint Object Camera offered the best precision and sensitivity to continue the hunt. Devised by European astronomers to complement the American wide field camera in the Hubble Space Telescope, the Faint Object Camera has a relatively narrow field of view. It intensifies the image of a faint object by repeatedly accelerating electrons from photo-electric films, so as to produce brighter flashes when the electrons hit a phosphor screen. Since Hubble's launch in 1990, the Faint Object Camera has examined many different kinds of cosmic objects, from the moons of Jupiter to remote galaxies and quasars. When the space telescope's optics were corrected at the end of 1993 the Faint Object Camera immediately celebrated the event with the discovery of primeval helium in intergalactic gas. In their search for Pulsar 1055-52, the astronomers chose a near-ultraviolet filter to sharpen the Faint Object Camera's vision and reduce the adjacent star's huge advantage in intensity. In May 1996, the Hubble Space Telescope operators aimed at the spot which radio astronomers had indicated, as the source of the radio pulsations of Pulsar 1055-52. The neutron star appeared precisely in the centre of the field of view, and it was clearly separated from the glare of the adjacent star. At magnitude 24.9, Pulsar 1055-52 was comfortably within the power of the Faint Object Camera, which can see stars 20 times fainter still. "The Faint Object Camera is the instrument of choice for looking for neutron stars," says Giovanni Bignami, speaking on behalf of the Italian team. "Whenever it points to a judiciously selected neutron star it detects the corresponding visible or ultraviolet light. The Faint Object Camera has now identified three neutron stars in that way, including Pulsar 1055-52, and it has examined a few that were first detected by other instruments." Mysteries of the neutron stars The importance of the new result can be gauged by the tally of only eight neutron stars seen so far at optical wavelengths, compared with about 760 known from their radio pulsations, and about 21 seen emitting X-rays. Since the first pulsar was detected by radio astronomers in Cambridge, England, nearly 30 years ago, theorists have come to recognize neutron stars as fantastic objects. They are veritable cosmic laboratories in which Nature reveals the behaviour of matter under extreme stress, just one step short of a black hole. A neutron star is created by the force of a supernova explosion in a large star, which crushes the star's core to an unimaginable density. A mass greater than the Sun's is squeezed into a ball no wider than a city. The gravity and magnetic fields are billions of times stronger than the Earth's. The neutron star revolves rapidly, which causes it to wink like a cosmic lighthouse as it swivels its magnetic poles towards and away from the Earth. Pulsar 1055-52 spins at five revolutions per second. At its formation in a supernova explosion, a neutron star is endowed with two main forms of energy. One is heat, at temperatures of millions of degrees, which the neutron star radiates mainly as X-rays, with only a small proportion emerging as visible light. The other power supply for the neutron star comes from its high rate of spin and a gradual slowing of the rotation. By a variety of processes involving the magnetic field and accelerated particles in the neutron star's vicinity, the spin energy of the neutron star is converted into radiation at many different wavelengths, from radio waves to gamma-rays. The exceptional gamma-ray intensity of Pulsar 1055-52 was first appreciated in observations by NASA's Compton Gamma Ray Observatory. The team in Milan recently used the Hubble Space Telescope to find the distance of the peculiar neutron star Geminga, which is not detectable by radio pulses but is a strong source of gamma-rays (see ESA Information Note 04-96, 28 March 1996). Pulsar 1055-52 is even more powerful in that respect. About 50 per cent of its radiant energy is gamma-rays, compared with 15 per cent from Geminga and 0.1 per cent from the famous Crab Pulsar, the first neutron star seen by visible light. Making the gamma-rays requires the acceleration of electrons through billions of volts. The magnetic environment of Pulsar 1055-52 fashions a natural gamma-ray machine of amazing power. The orientation of the neutron star's magnetic field with respect to the Earth may contribute to its brightness in gamma-rays. Geminga, Pulsar 1055-52 and another object, Pulsar 0656+14, make a trio that the Milanese astronomers call the Three Musketeers. All have been observed with the Faint Object Camera. They are isolated, elderly neutron stars, some hundreds of thousands of years old, contrasting with the 942 year-old Crab Pulsar which is still surrounded by dispersing debris of a supernova seen by Chinese astronomers in the 11th Century. The mysteries of the neutron stars will keep astronomers busy for years to come, and the Faint Object Camera in the Hubble Space Telescope will remain the best instrument for spotting their faint visible light. The Hubble Space Telescope is a project of international cooperation between NASA and the European Space Agency (ESA). The Space Telescope Science Institute is operated by the Association of Universities for Research in Astronomy, Inc. (AURA) for NASA, under contract with the Goddard Space Flight Center, Greenbelt, Maryland. Note to editors: An image is available of (i) PSR 1055-52 seen by ESA's Faint Object Camera in the Hubble Space Telescope, and (ii) the same region of the sky seen by the European Southern Observatory's New Technology Telescope, with the position of PSR 1055-52 indicated. The image is available on the World Wide Web at http://ecf.hq.eso.org/stecf-pubrel.html http://www.estec.esa.nl/spdwww/h2000/html/snlmain.htm

Gamma Ray Burst Optical Counterpart Search Experiment (GROCSE)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, H.S.; Ables, E.; Bionta, R.M.

GROCSE (Gamma-Ray Optical Counterpart Search Experiments) is a system of automated telescopes that search for simultaneous optical activity associated with gamma ray bursts in response to real-time burst notifications provided by the BATSE/BACODINE network. The first generation system, GROCSE 1, is sensitive down to Mv {approximately} 8.5 and requires an average of 12 seconds to obtain the first images of the gamma ray burst error box defined by the BACODINE trigger. The collaboration is now constructing a second generation system which has a 4 second slewing time and can reach Mv {approximately} 14 with a 5 second exposure. GROCSE 2more » consists of 4 cameras on a single mount. Each camera views the night sky through a commercial Canon lens (f/1.8, focal length 200 mm) and utilizes a 2K x 2K Loral CCD. Light weight and low noise custom readout electronics were designed and fabricated for these CCDs. The total field of view of the 4 cameras is 17.6 x 17.6 {degree}. GROCSE II will be operated by the end of 1995. In this paper, the authors present an overview of the GROCSE system and the results of measurements with a GROCSE 2 prototype unit.« less

MO-AB-206-02: Testing Gamma Cameras Based On TG177 WG Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halama, J.

2016-06-15

This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Bemore » able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT images for SPECT reconstructions. Become knowledgeable of items to be included in annual acceptance testing reports including CT dosimetry and PACS monitor measurements. T. Turkington, GE Healthcare.« less

Impact of intense x-ray pulses on a NaI(Tl)-based gamma camera

NASA Astrophysics Data System (ADS)

Koppert, W. J. C.; van der Velden, S.; Steenbergen, J. H. L.; de Jong, H. W. A. M.

2018-03-01

In SPECT/CT systems x-ray and γ-ray imaging is performed sequentially. Simultaneous acquisition may have advantages, for instance in interventional settings. However, this may expose a gamma camera to relatively high x-ray doses and deteriorate its functioning. We studied the NaI(Tl) response to x-ray pulses with a photodiode, PMT and gamma camera, respectively. First, we exposed a NaI(Tl)-photodiode assembly to x-ray pulses to investigate potential crystal afterglow. Next, we exposed a NaI(Tl)-PMT assembly to 10 ms LED pulses (mimicking x-ray pulses) and measured the response to flashing LED probe-pulses (mimicking γ-pulses). We then exposed the assembly to x-ray pulses, with detector entrance doses of up to 9 nGy/pulse, and analysed the response for γ-pulse variations. Finally, we studied the response of a Siemens Diacam gamma camera to γ-rays while exposed to x-ray pulses. X-ray exposure of the crystal, read out with a photodiode, revealed 15% afterglow fraction after 3 ms. The NaI(Tl)-PMT assembly showed disturbances up to 10 ms after 10 ms LED exposure. After x-ray exposure however, responses showed elevated baselines, with 60 ms decay-time. Both for x-ray and LED exposure and after baseline subtraction, probe-pulse analysis revealed disturbed pulse height measurements shortly after exposure. X-ray exposure of the Diacam corroborated the elementary experiments. Up to 50 ms after an x-ray pulse, no events are registered, followed by apparent energy elevations up to 100 ms after exposure. Limiting the dose to 0.02 nGy/pulse prevents detrimental effects. Conventional gamma cameras exhibit substantial dead-time and mis-registration of photon energies up to 100 ms after intense x-ray pulses. This is due PMT limitations and due to afterglow in the crystal. Using PMTs with modified circuitry, we show that deteriorative afterglow effects can be reduced without noticeable effects on the PMT performance, up to x-ray pulse doses of 1 nGy.

Prompt-gamma monitoring in hadrontherapy: A review

NASA Astrophysics Data System (ADS)

Krimmer, J.; Dauvergne, D.; Létang, J. M.; Testa, É.

2018-01-01

Secondary radiation emission induced by nuclear reactions is correlated to the path of ions in matter. Therefore, such penetrating radiation can be used for in vivo control of hadrontherapy treatments, for which the primary beam is absorbed inside the patient. Among secondary radiations, prompt-gamma rays were proposed for real-time verification of ion range. Such a verification is a desired condition to reduce uncertainties in treatment planning. For more than a decade, efforts have been undertaken worldwide to promote prompt-gamma-based devices to be used in clinical conditions. Dedicated cameras are necessary to overcome the challenges of a broad- and high-energy distribution, a large background, high instantaneous count rates, and compatibility constraints with patient irradiation. Several types of prompt-gamma imaging devices have been proposed, that are either physically-collimated or electronically collimated (Compton cameras). Clinical tests are now undergoing. Meanwhile, other methods than direct prompt-gamma imaging were proposed, that are based on specific counting using either time-of-flight or photon energy measurements. In the present article, we make a review and discuss the state of the art for all techniques using prompt-gamma detection to improve the quality assurance in hadrontherapy.

Application of imaging to the atmospheric Cherenkov technique

NASA Technical Reports Server (NTRS)

Cawley, M. F.; Fegan, D. J.; Gibbs, K.; Gorham, P. W.; Hillas, A. M.; Lamb, R. C.; Liebing, D. F.; Mackeown, P. K.; Porter, N. A.; Stenger, V. J.

1985-01-01

Turver and Weekes proposed using a system of phototubes in the focal plane of a large reflector to give an air Cherenkov camera for gamma ray astronomy. Preliminary results with a 19 element camera have been reported previously. In 1983 the camera was increased to 37 pixels; it has now been routinely operated for two years. A brief physical description of the camera, its mode of operation, and the data reduction procedures are presented. The Monte Carlo simultations on which these are based on also reviewed.

Performance and field tests of a handheld Compton camera using 3-D position-sensitive scintillators coupled to multi-pixel photon counter arrays

NASA Astrophysics Data System (ADS)

Kishimoto, A.; Kataoka, J.; Nishiyama, T.; Fujita, T.; Takeuchi, K.; Okochi, H.; Ogata, H.; Kuroshima, H.; Ohsuka, S.; Nakamura, S.; Hirayanagi, M.; Adachi, S.; Uchiyama, T.; Suzuki, H.

2014-11-01

After the nuclear disaster in Fukushima, radiation decontamination has become particularly urgent. To help identify radiation hotspots and ensure effective decontamination operation, we have developed a novel Compton camera based on Ce-doped Gd3Al2Ga3O12 scintillators and multi-pixel photon counter (MPPC) arrays. Even though its sensitivity is several times better than that of other cameras being tested in Fukushima, we introduce a depth-of-interaction (DOI) method to further improve the angular resolution. For gamma rays, the DOI information, in addition to 2-D position, is obtained by measuring the pulse-height ratio of the MPPC arrays coupled to ends of the scintillator. We present the detailed performance and results of various field tests conducted in Fukushima with the prototype 2-D and DOI Compton cameras. Moreover, we demonstrate stereo measurement of gamma rays that enables measurement of not only direction but also approximate distance to radioactive hotspots.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ivanov, Oleg P.; Semin, Ilya A.; Potapov, Victor N.

Gamma-ray imaging is the most important way to identify unknown gamma-ray emitting objects in decommissioning, security, overcoming accidents. Over the past two decades a system for producing of gamma images in these conditions became more or less portable devices. But in recent years these systems have become the hand-held devices. This is very important, especially in emergency situations, and measurements for safety reasons. We describe the first integrated hand-held instrument for emergency and security applications. The device is based on the coded aperture image formation, position sensitive gamma-ray (X-ray) detector Medipix2 (detectors produces by X-ray Imaging Europe) and tablet computer.more » The development was aimed at creating a very low weight system with high angular resolution. We present some sample gamma-ray images by camera. Main estimated parameters of the system are the following. The field of view video channel ∼ 490 deg. The field of view gamma channel ∼ 300 deg. The sensitivity of the system with a hexagonal mask for the source of Cs-137 (Eg = 662 keV), is in units of dose D ∼ 100 mR. This option is less then order of magnitude worse than for the heavy, non-hand-held systems (e.g., gamma-camera Cartogam, by Canberra.) The angular resolution of the gamma channel for the sources of Cs-137 (Eg = 662 keV) is about 1.20 deg. (authors)« less

Precision imaging of 4.4 MeV gamma rays using a 3-D position sensitive Compton camera.

PubMed

Koide, Ayako; Kataoka, Jun; Masuda, Takamitsu; Mochizuki, Saku; Taya, Takanori; Sueoka, Koki; Tagawa, Leo; Fujieda, Kazuya; Maruhashi, Takuya; Kurihara, Takuya; Inaniwa, Taku

2018-05-25

Imaging of nuclear gamma-ray lines in the 1-10 MeV range is far from being established in both medical and physical applications. In proton therapy, 4.4 MeV gamma rays are emitted from the excited nucleus of either 12 C* or 11 B* and are considered good indicators of dose delivery and/or range verification. Further, in gamma-ray astronomy, 4.4 MeV gamma rays are produced by cosmic ray interactions in the interstellar medium, and can thus be used to probe nucleothynthesis in the universe. In this paper, we present a high-precision image of 4.4 MeV gamma rays taken by newly developed 3-D position sensitive Compton camera (3D-PSCC). To mimic the situation in proton therapy, we first irradiated water, PMMA and Ca(OH)2 with a 70 MeV proton beam, then we identified various nuclear lines with the HPGe detector. The 4.4 MeV gamma rays constitute a broad peak, including single and double escape peaks. Thus, by setting an energy window of 3D-PSCC from 3 to 5 MeV, we show that a gamma ray image sharply concentrates near the Bragg peak, as expected from the minimum energy threshold and sharp peak profile in the cross section of 12 C(p,p) 12 C*.

Measurement of total-body cobalt-57 vitamin B12 absorption with a gamma camera.

PubMed

Cardarelli, J A; Slingerland, D W; Burrows, B A; Miller, A

1985-08-01

Previously described techniques for the measurement of the absorption of [57Co]vitamin B12 by total-body counting have required an iron room equipped with scanning or multiple detectors. The present study uses simplifying modifications which make the technique more available and include the use of static geometry, the measurement of body thickness to correct for attenuation, a simple formula to convert the capsule-in-air count to a 100% absorption count, and finally the use of an adequately shielded gamma camera obviating the need of an iron room.

Iodine 125 Imaging in Mice Using NaI(Tl)/Flat Panel PMT Integral Assembly

NASA Astrophysics Data System (ADS)

Cinti, M. N.; Majewski, S.; Williams, M. B.; Bachmann, C.; Cominelli, F.; Kundu, B. K.; Stolin, A.; Popov, V.; Welch, B. L.; De Vincentis, G.; Bennati, P.; Betti, M.; Ridolfi, S.; Pani, R.

2007-06-01

Radiolabeled agents that bind to specific receptors have shown great promise in diagnosing and characterizing tumor cell biology. In vivo imaging of gene transcription and protein expression represents an other area of interest. The radioisotope I is commercially available as a label for molecular probes and utilized by researchers in small animal studies. We propose an advanced imaging detector based on planar NaI(T1) integral assembly with a Hamamatsu Flat Panel Photomultiplier (MA-PMT) representing one of the best trade-offs between spatial resolution and detection efficiency. We characterized the imaging performances of this planar detector, in comparison with a gamma camera based on a pixellated scintillator. We also tested the in-vivo image capability by acquiring images of mice as a part of a study of inflammatory bowel disease (IBD). In this study, four 25g mice with an IBD-like phenotype (SAMP1/YitFc) were injected with 375, 125, 60 and 30 muCi of I-labelled antibody against mucosal vascular addressin cell adhesion molecule (MAdCAM-1), which is up-regulated in the presence of inflammation. Two mice without bowel inflammation were injected with 150 and 60 muCi of the labeled anti-MAdCAM-1 antibody as controls. To better evaluate the performances of the integral assembly detector, we also acquired mice images with a dual modality (X and Gamma Ray) camera dedicated for small animal imaging. The results coming from this new detector are considerable: images of SAMP1/YitFc injected with 30 muCi activity show inflammation throughout the intestinal tract, with the disease very well defined at two hours post-injection.

Flexible mini gamma camera reconstructions of extended sources using step and shoot and list mode.

PubMed

Gardiazabal, José; Matthies, Philipp; Vogel, Jakob; Frisch, Benjamin; Navab, Nassir; Ziegler, Sibylle; Lasser, Tobias

2016-12-01

Hand- and robot-guided mini gamma cameras have been introduced for the acquisition of single-photon emission computed tomography (SPECT) images. Less cumbersome than whole-body scanners, they allow for a fast acquisition of the radioactivity distribution, for example, to differentiate cancerous from hormonally hyperactive lesions inside the thyroid. This work compares acquisition protocols and reconstruction algorithms in an attempt to identify the most suitable approach for fast acquisition and efficient image reconstruction, suitable for localization of extended sources, such as lesions inside the thyroid. Our setup consists of a mini gamma camera with precise tracking information provided by a robotic arm, which also provides reproducible positioning for our experiments. Based on a realistic phantom of the thyroid including hot and cold nodules as well as background radioactivity, the authors compare "step and shoot" (SAS) and continuous data (CD) acquisition protocols in combination with two different statistical reconstruction methods: maximum-likelihood expectation-maximization (ML-EM) for time-integrated count values and list-mode expectation-maximization (LM-EM) for individually detected gamma rays. In addition, the authors simulate lower uptake values by statistically subsampling the experimental data in order to study the behavior of their approach without changing other aspects of the acquired data. All compared methods yield suitable results, resolving the hot nodules and the cold nodule from the background. However, the CD acquisition is twice as fast as the SAS acquisition, while yielding better coverage of the thyroid phantom, resulting in qualitatively more accurate reconstructions of the isthmus between the lobes. For CD acquisitions, the LM-EM reconstruction method is preferable, as it yields comparable image quality to ML-EM at significantly higher speeds, on average by an order of magnitude. This work identifies CD acquisition protocols combined with LM-EM reconstruction as a prime candidate for the wider introduction of SPECT imaging with flexible mini gamma cameras in the clinical practice.

Simultaneous fluoroscopic and nuclear imaging: impact of collimator choice on nuclear image quality.

PubMed

van der Velden, Sandra; Beijst, Casper; Viergever, Max A; de Jong, Hugo W A M

2017-01-01

X-ray-guided oncological interventions could benefit from the availability of simultaneously acquired nuclear images during the procedure. To this end, a real-time, hybrid fluoroscopic and nuclear imaging device, consisting of an X-ray c-arm combined with gamma imaging capability, is currently being developed (Beijst C, Elschot M, Viergever MA, de Jong HW. Radiol. 2015;278:232-238). The setup comprises four gamma cameras placed adjacent to the X-ray tube. The four camera views are used to reconstruct an intermediate three-dimensional image, which is subsequently converted to a virtual nuclear projection image that overlaps with the X-ray image. The purpose of the present simulation study is to evaluate the impact of gamma camera collimator choice (parallel hole versus pinhole) on the quality of the virtual nuclear image. Simulation studies were performed with a digital image quality phantom including realistic noise and resolution effects, with a dynamic frame acquisition time of 1 s and a total activity of 150 MBq. Projections were simulated for 3, 5, and 7 mm pinholes and for three parallel hole collimators (low-energy all-purpose (LEAP), low-energy high-resolution (LEHR) and low-energy ultra-high-resolution (LEUHR)). Intermediate reconstruction was performed with maximum likelihood expectation-maximization (MLEM) with point spread function (PSF) modeling. In the virtual projection derived therefrom, contrast, noise level, and detectability were determined and compared with the ideal projection, that is, as if a gamma camera were located at the position of the X-ray detector. Furthermore, image deformations and spatial resolution were quantified. Additionally, simultaneous fluoroscopic and nuclear images of a sphere phantom were acquired with a physical prototype system and compared with the simulations. For small hot spots, contrast is comparable for all simulated collimators. Noise levels are, however, 3 to 8 times higher in pinhole geometries than in parallel hole geometries. This results in higher contrast-to-noise ratios for parallel hole geometries. Smaller spheres can thus be detected with parallel hole collimators than with pinhole collimators (17 mm vs 28 mm). Pinhole geometries show larger image deformations than parallel hole geometries. Spatial resolution varied between 1.25 cm for the 3 mm pinhole and 4 cm for the LEAP collimator. The simulation method was successfully validated by the experiments with the physical prototype. A real-time hybrid fluoroscopic and nuclear imaging device is currently being developed. Image quality of nuclear images obtained with different collimators was compared in terms of contrast, noise, and detectability. Parallel hole collimators showed lower noise and better detectability than pinhole collimators. © 2016 American Association of Physicists in Medicine.

AIRWAY IDENTIFICATION WITHIN PLANAR GAMMA CAMERA IMAGES USING COMPUTER MODELS OF LUNG MORPHOLOGY

EPA Science Inventory

The quantification of inhaled aerosols could be improved if a more comprehensive assessment of their spatial distribution patterns among lung airways were obtained. A common technique for quantifying particle deposition in human lungs is with planar gamma scintigraphy. However, t...

Light-Trap: a SiPM upgrade for VHE astronomy and beyond

NASA Astrophysics Data System (ADS)

Ward, J. E.; Cortina, J.; Guberman, D.

2016-11-01

Ground-based gamma-ray astronomy in the Very High Energy (VHE, E > 100 GeV) regime has fast become one of the most interesting and productive sub-fields of astrophysics today. Utilizing the Imaging Atmospheric Cherenkov Technique (IACT) to reconstruct the energy and direction of incoming gamma-ray photons from the universe, several source-classes have been revealed by previous and current generations of IACT telescopes (e.g. Whipple, MAGIC, HESS and VERITAS). The next generation pointing IACT experiment, the Cherenkov Telescope Array (CTA), will provide increased sensitivity across a wider energy range and with better angular resolution. With the development of CTA, the future of IACT pointing arrays is being directed towards having more and more telescopes (and hence cameras), and therefore the need to develop low-cost pixels with acceptable light-collection efficiency is clear. One of the primary paths to the above goal is to replace Photomultiplier Tubes (PMTs) with Silicon-PMs (SiPMs) as the pixels in IACT telescope cameras. However SiPMs are not yet mature enough to replace PMTs for several reasons: sensitivity to unwanted longer wavelengths while lacking sensitivity at short wavelengths, small physical area, high cost, optical cross-talk and dark rates. Here we propose a novel method to build relatively low-cost SiPM-based pixels utilising a disk of wavelength-shifting material, which overcomes some of these drawbacks by collecting light over a larger area than standard SiPMs and improving sensitivity to shorter wavelengths while reducing background. We aim to optimise the design of such pixels, integrating them into an actual 7-pixel cluster which will be inserted into a MAGIC camera and tested during real observations. Results of simulations, laboratory measurements and the current status of the cluster design and development will be presented.

Development of an LYSO based gamma camera for positron and scinti-mammography

NASA Astrophysics Data System (ADS)

Liang, H.-C.; Jan, M.-L.; Lin, W.-C.; Yu, S.-F.; Su, J.-L.; Shen, L.-H.

2009-08-01

In this research, characteristics of combination of PSPMTs (position sensitive photo-multiplier tube) to form a larger detection area is studied. A home-made linear divider circuit was built for merging signals and readout. Borosilicate glasses were chosen for the scintillation light sharing in the crossover region. Deterioration effect caused by the light guide was understood. The influences of light guide and crossover region on the separable crystal size were evaluated. According to the test results, a gamma camera with a crystal block of 90 × 90 mm2 covered area, composed of 2 mm LYSO crystal pixels, was designed and fabricated. Measured performances showed that this camera worked fine in both 511 keV and lower energy gammas. The light loss behaviour within the crossover region was analyzed and realized. Through count rate measurements, the 176Lu nature background didn't show severe influence on the single photon imaging and exhibited an amount of less than 1/3 of all the events acquired. These results show that with using light sharing techniques, combination of multiple PSPMTs in both X and Y directions to build a large area imaging detector is capable to be achieved. Also this camera design is feasible to keep both the abilities for positron and single photon breast imaging applications. Separable crystal size is 2 mm with 2 mm thick glass applied for the light sharing in current status.

An improved camera trap for amphibians, reptiles, small mammals, and large invertebrates

USGS Publications Warehouse

Hobbs, Michael T.; Brehme, Cheryl S.

2017-01-01

Camera traps are valuable sampling tools commonly used to inventory and monitor wildlife communities but are challenged to reliably sample small animals. We introduce a novel active camera trap system enabling the reliable and efficient use of wildlife cameras for sampling small animals, particularly reptiles, amphibians, small mammals and large invertebrates. It surpasses the detection ability of commonly used passive infrared (PIR) cameras for this application and eliminates problems such as high rates of false triggers and high variability in detection rates among cameras and study locations. Our system, which employs a HALT trigger, is capable of coupling to digital PIR cameras and is designed for detecting small animals traversing small tunnels, narrow trails, small clearings and along walls or drift fencing.

An improved camera trap for amphibians, reptiles, small mammals, and large invertebrates.

PubMed

Hobbs, Michael T; Brehme, Cheryl S

2017-01-01

Camera traps are valuable sampling tools commonly used to inventory and monitor wildlife communities but are challenged to reliably sample small animals. We introduce a novel active camera trap system enabling the reliable and efficient use of wildlife cameras for sampling small animals, particularly reptiles, amphibians, small mammals and large invertebrates. It surpasses the detection ability of commonly used passive infrared (PIR) cameras for this application and eliminates problems such as high rates of false triggers and high variability in detection rates among cameras and study locations. Our system, which employs a HALT trigger, is capable of coupling to digital PIR cameras and is designed for detecting small animals traversing small tunnels, narrow trails, small clearings and along walls or drift fencing.

Astronomy Legacy Project - Pisgah Astronomical Research Institute

NASA Astrophysics Data System (ADS)

Barker, Thurburn; Castelaz, Michael W.; Rottler, Lee; Cline, J. Donald

2016-01-01

Pisgah Astronomical Research Institute (PARI) is a not-for-profit public foundation in North Carolina dedicated to providing hands-on educational and research opportunities for a broad cross-section of users in science, technology, engineering and math (STEM) disciplines. In November 2007 a Workshop on a National Plan for Preserving Astronomical Photographic Data (2009ASPC,410,33O, Osborn, W. & Robbins, L) was held at PARI. The result was the establishment of the Astronomical Photographic Data Archive (APDA) at PARI. In late 2013 PARI began ALP (Astronomy Legacy Project). ALP's purpose is to digitize an extensive set of twentieth century photographic astronomical data housed in APDA. Because of the wide range of types of plates, plate dimensions and emulsions found among the 40+ collections, plate digitization will require a versatile set of scanners and digitizing instruments. Internet crowdfunding was used to assist in the purchase of additional digitization equipment that were described at AstroPlate2014 Plate Preservation Workshop (www.astroplate.cz) held in Prague, CZ, March, 2014. Equipment purchased included an Epson Expression 11000XL scanner and two Nikon D800E cameras. These digital instruments will compliment a STScI GAMMA scanner now located in APDA. GAMMA will be adapted to use an electroluminescence light source and a digital camera with a telecentric lens to achieve high-speed high-resolution scanning. The 1μm precision XY stage of GAMMA will allow very precise positioning of the plate stage. Multiple overlapping CCD images of small sections of each plate, tiles, will be combined using a photo-mosaic process similar to one used in Harvard's DASCH project. Implementation of a software pipeline for the creation of a SQL database containing plate images and metadata will be based upon APPLAUSE as described by Tuvikene at AstroPlate2014 (www.astroplate.cz/programs/).

Multiple window spatial registration error of a gamma camera: 133Ba point source as a replacement of the NEMA procedure.

PubMed

Bergmann, Helmar; Minear, Gregory; Raith, Maria; Schaffarich, Peter M

2008-12-09

The accuracy of multiple window spatial resolution characterises the performance of a gamma camera for dual isotope imaging. In the present study we investigate an alternative method to the standard NEMA procedure for measuring this performance parameter. A long-lived 133Ba point source with gamma energies close to 67Ga and a single bore lead collimator were used to measure the multiple window spatial registration error. Calculation of the positions of the point source in the images used the NEMA algorithm. The results were validated against the values obtained by the standard NEMA procedure which uses a liquid 67Ga source with collimation. Of the source-collimator configurations under investigation an optimum collimator geometry, consisting of a 5 mm thick lead disk with a diameter of 46 mm and a 5 mm central bore, was selected. The multiple window spatial registration errors obtained by the 133Ba method showed excellent reproducibility (standard deviation < 0.07 mm). The values were compared with the results from the NEMA procedure obtained at the same locations and showed small differences with a correlation coefficient of 0.51 (p < 0.05). In addition, the 133Ba point source method proved to be much easier to use. A Bland-Altman analysis showed that the 133Ba and the 67Ga Method can be used interchangeably. The 133Ba point source method measures the multiple window spatial registration error with essentially the same accuracy as the NEMA-recommended procedure, but is easier and safer to use and has the potential to replace the current standard procedure.

Tissue-equivalent TL sheet dosimetry system for X- and gamma-ray dose mapping.

PubMed

Nariyama, N; Konnai, A; Ohnishi, S; Odano, N; Yamaji, A; Ozasa, N; Ishikawa, Y

2006-01-01

To measure dose distribution for X- and gamma rays simply and accurately, a tissue-equivalent thermoluminescent (TL) sheet-type dosemeter and reader system were developed. The TL sheet is composed of LiF:Mg,Cu,P and ETFE polymer, and the thickness is 0.2 mm. For the TL reading, a square heating plate, 20 cm on each side, was developed, and the temperature distribution was measured with an infrared thermal imaging camera. As a result, linearity within 2% and the homogeneity within 3% were confirmed. The TL signal emitted is detected using a CCD camera and displayed as a spatial dose distribution. Irradiation using synchrotron radiation between 10 and 100 keV and (60)Co gamma rays showed that the TL sheet dosimetry system was promising for radiation dose mapping for various purposes.

SU-F-J-200: An Improved Method for Event Selection in Compton Camera Imaging for Particle Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mackin, D; Beddar, S; Polf, J

2016-06-15

Purpose: The uncertainty in the beam range in particle therapy limits the conformality of the dose distributions. Compton scatter cameras (CC), which measure the prompt gamma rays produced by nuclear interactions in the patient tissue, can reduce this uncertainty by producing 3D images confirming the particle beam range and dose delivery. However, the high intensity and short time windows of the particle beams limit the number of gammas detected. We attempt to address this problem by developing a method for filtering gamma ray scattering events from the background by applying the known gamma ray spectrum. Methods: We used a 4more » stage Compton camera to record in list mode the energy deposition and scatter positions of gammas from a Co-60 source. Each CC stage contained a 4×4 array of CdZnTe crystal. To produce images, we used a back-projection algorithm and four filtering Methods: basic, energy windowing, delta energy (ΔE), or delta scattering angle (Δθ). Basic filtering requires events to be physically consistent. Energy windowing requires event energy to fall within a defined range. ΔE filtering selects events with the minimum difference between the measured and a known gamma energy (1.17 and 1.33 MeV for Co-60). Δθ filtering selects events with the minimum difference between the measured scattering angle and the angle corresponding to a known gamma energy. Results: Energy window filtering reduced the FWHM from 197.8 mm for basic filtering to 78.3 mm. ΔE and Δθ filtering achieved the best results, FWHMs of 64.3 and 55.6 mm, respectively. In general, Δθ filtering selected events with scattering angles < 40°, while ΔE filtering selected events with angles > 60°. Conclusion: Filtering CC events improved the quality and resolution of the corresponding images. ΔE and Δθ filtering produced similar results but each favored different events.« less

ProxiScan™: A Novel Camera for Imaging Prostate Cancer

ScienceCinema

Ralph James

2017-12-09

ProxiScan is a compact gamma camera suited for high-resolution imaging of prostate cancer. Developed by Brookhaven National Laboratory and Hybridyne Imaging Technologies, Inc., ProxiScan won a 2009 R&D 100 Award, sponsored by R&D Magazine to recognize t

Passive radiation detection using optically active CMOS sensors

NASA Astrophysics Data System (ADS)

Dosiek, Luke; Schalk, Patrick D.

2013-05-01

Recently, there have been a number of small-scale and hobbyist successes in employing commodity CMOS-based camera sensors for radiation detection. For example, several smartphone applications initially developed for use in areas near the Fukushima nuclear disaster are capable of detecting radiation using a cell phone camera, provided opaque tape is placed over the lens. In all current useful implementations, it is required that the sensor not be exposed to visible light. We seek to build a system that does not have this restriction. While building such a system would require sophisticated signal processing, it would nevertheless provide great benefits. In addition to fulfilling their primary function of image capture, cameras would also be able to detect unknown radiation sources even when the danger is considered to be low or non-existent. By experimentally profiling the image artifacts generated by gamma ray and β particle impacts, algorithms are developed to identify the unique features of radiation exposure, while discarding optical interaction and thermal noise effects. Preliminary results focus on achieving this goal in a laboratory setting, without regard to integration time or computational complexity. However, future work will seek to address these additional issues.

High-resolution mini gamma camera for diagnosis and radio-guided surgery in diabetic foot infection

NASA Astrophysics Data System (ADS)

Scopinaro, F.; Capriotti, G.; Di Santo, G.; Capotondi, C.; Micarelli, A.; Massari, R.; Trotta, C.; Soluri, A.

2006-12-01

The diagnosis of diabetic foot osteomyelitis is often difficult. 99mTc-WBC (White Blood Cell) scintigraphy plays a key role in the diagnosis of bone infections. Spatial resolution of Anger camera is not always able to differentiate soft tissue from bone infection. Aim of present study is to verify if HRD (High-Resolution Detector) is able to improve diagnosis and to help surgery. Patients were studied by HRD showing 25.7×25.7 mm 2 FOV, 2 mm spatial resolution and 18% energy resolution. The patients were underwent to surgery and, when necessary, bone biopsy, both guided by HRD. Four patients were positive at Anger camera without specific signs of osteomyelitis. HRS (High-Resolution Scintigraphy) showed hot spots in the same patients. In two of them the hot spot was bar-shaped and it was localized in correspondence of the small phalanx. The presence of bone infection was confirmed at surgery, which was successfully guided by HRS. 99mTc-WBC HRS was able to diagnose pedal infection and to guide the surgery of diabetic foot, opening a new way in the treatment of infected diabetic foot.

An improved camera trap for amphibians, reptiles, small mammals, and large invertebrates

PubMed Central

2017-01-01

Camera traps are valuable sampling tools commonly used to inventory and monitor wildlife communities but are challenged to reliably sample small animals. We introduce a novel active camera trap system enabling the reliable and efficient use of wildlife cameras for sampling small animals, particularly reptiles, amphibians, small mammals and large invertebrates. It surpasses the detection ability of commonly used passive infrared (PIR) cameras for this application and eliminates problems such as high rates of false triggers and high variability in detection rates among cameras and study locations. Our system, which employs a HALT trigger, is capable of coupling to digital PIR cameras and is designed for detecting small animals traversing small tunnels, narrow trails, small clearings and along walls or drift fencing. PMID:28981533

Development of Camera Electronics for the Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Tajima, Hiroyasu

2009-05-01

AGIS, a next generation of atmospheric Cherenkov telescope arrays, aims to achieve a sensitivity level of a milliCrab for gamma-ray observations in in the energy band of 40 GeV to 100 TeV. Such improvement requires cost reduction of individual components with high reliability in order to equip the order of 100 telescopes necessary to achieve the sensitivity goal. We are exploring several design concepts to reduce the cost of camera electronics while improving their performance. We have developed test systems for some of these concepts and are testing their performance. Here we present test results of the test systems.

Improved neutron-gamma discrimination for a {sup 6}Li-glass neutron detector using digital signal analysis methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, C. L., E-mail: wangc@ornl.gov; Riedel, R. A.

2016-01-15

A {sup 6}Li-glass scintillator (GS20) based neutron Anger camera was developed for time-of-flight single-crystal diffraction instruments at Spallation Neutron Source. Traditional Pulse-Height Analysis (PHA) for Neutron-Gamma Discrimination (NGD) resulted in the neutron-gamma efficiency ratio (defined as NGD ratio) on the order of 10{sup 4}. The NGD ratios of Anger cameras need to be improved for broader applications including neutron reflectometers. For this purpose, six digital signal analysis methods of individual waveforms acquired from photomultiplier tubes were proposed using (i) charge integration, (ii) pulse-amplitude histograms, (iii) power spectrum analysis combined with the maximum pulse-amplitude, (iv) two event parameters (a{sub 1}, b{submore » 0}) obtained from a Wiener filter, (v) an effective amplitude (m) obtained from an adaptive least-mean-square filter, and (vi) a cross-correlation coefficient between individual and reference waveforms. The NGD ratios are about 70 times those from the traditional PHA method. Our results indicate the NGD capabilities of neutron Anger cameras based on GS20 scintillators can be significantly improved with digital signal analysis methods.« less

Establishment of Imaging Spectroscopy of Nuclear Gamma-Rays based on Geometrical Optics

PubMed Central

Tanimori, Toru; Mizumura, Yoshitaka; Takada, Atsushi; Miyamoto, Shohei; Takemura, Taito; Kishimoto, Tetsuro; Komura, Shotaro; Kubo, Hidetoshi; Kurosawa, Shunsuke; Matsuoka, Yoshihiro; Miuchi, Kentaro; Mizumoto, Tetsuya; Nakamasu, Yuma; Nakamura, Kiseki; Parker, Joseph D.; Sawano, Tatsuya; Sonoda, Shinya; Tomono, Dai; Yoshikawa, Kei

2017-01-01

Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain quantitative imaging, cameras that realize geometrical optics is essential, which would be, for nuclear MeV gammas, only possible via complete reconstruction of the Compton process. Recently we have revealed that “Electron Tracking Compton Camera” (ETCC) provides a well-defined Point Spread Function (PSF). The information of an incoming gamma is kept along a ray with the PSF and that is equivalent to geometrical optics. Here we present an imaging-spectroscopic measurement with the ETCC. Our results highlight the intrinsic difficulty with CCs in performing accurate imaging, and show that the ETCC surmounts this problem. The imaging capability also helps the ETCC suppress the noise level dramatically by ~3 orders of magnitude without a shielding structure. Furthermore, full reconstruction of Compton process with the ETCC provides spectra free of Compton edges. These results mark the first proper imaging of nuclear gammas based on the genuine geometrical optics. PMID:28155870

Performance Evaluation of 98 CZT Sensors for Their Use in Gamma-Ray Imaging

NASA Astrophysics Data System (ADS)

Dedek, Nicolas; Speller, Robert D.; Spendley, Paul; Horrocks, Julie A.

2008-10-01

98 SPEAR sensors from eV Products have been evaluated for their use in a portable Compton camera. The sensors have a 5 mm times 5 mm times 5 mm CdZnTe crystal and are provided together with a preamplifier. The energy resolution was studied in detail for all sensors and was found to be 6% on average at 59.5 keV and 3% on average at 662 keV. The standard deviations of the corresponding energy resolution distributions are remarkably small (0.6% at 59.5 keV, 0.7% at 662 keV) and reflect the uniformity of the sensor characteristics. For a possible outside use the temperature dependence of the sensor performances was investigated for temperatures between 15 and 45 deg Celsius. A linear shift in calibration with temperature was observed. The energy resolution at low energies (81 keV) was found to deteriorate exponentially with temperature, while it stayed constant at higher energies (356 keV). A Compton camera built of these sensors was simulated. To obtain realistic energy spectra a suitable detector response function was implemented. To investigate the angular resolution of the camera a 137Cs point source was simulated. Reconstructed images of the point source were compared for perfect and realistic energy and position resolutions. The angular resolution of the camera was found to be better than 10 deg.

The effects of Doppler broadening and detector resolution on the performance of three-stage Compton cameras

PubMed Central

Mackin, Dennis; Polf, Jerimy; Peterson, Steve; Beddar, Sam

2013-01-01

Purpose: The authors investigated how the characteristics of the detectors used in a three-stage Compton camera (CC) affect the CC's ability to accurately measure the emission distribution and energy spectrum of prompt gammas (PG) emitted by nuclear de-excitations during proton therapy. The detector characteristics they studied included the material (high-purity germanium [HPGe] and cadmium zinc telluride [CZT]), Doppler broadening (DB), and resolution (lateral, depth, and energy). Methods: The authors simulated three-stage HPGe and CZT CCs of various configurations, detecting gammas from point sources with energies ranging from 0.511 to 7.12 MeV. They also simulated a proton pencil beam irradiating a tissue target to study how the detector characteristics affect the PG data measured by CCs in a clinical proton therapy setting. They used three figures of merit: the distance of closest approach (DCA) and the point of closest approach (PCA) between the measured and actual position of the PG emission origin, and the calculated energy resolution. Results: For CCs with HPGe detectors, DB caused the DCA to be greater than 3 mm for 14% of the 6.13 MeV gammas and 20% of the 0.511 MeV gammas. For CCs with CZT detectors, DB caused the DCA to be greater than 3 mm for 18% of the 6.13 MeV gammas and 25% of the 0.511 MeV gammas. The full width at half maximum (FWHM) of the PCA in the \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} \\begin{equation*}\\hat z\\end{equation*} \\end{document}z^ direction for HPGe and CZT detectors ranged from 1.3 to 0.4 mm for gammas with incident energy ranging from 0.511 to 7.12 MeV. For CCs composed of HPGe detectors, the resolution of incident gamma energy calculated by the CC ranged from 6% to 1% for gammas with true incident energies from 0.511 to 7.12 MeV. For CCs composed of CZT detectors, the resolution of gamma energy calculated by the CC ranged from 10% to 1% for gammas with true incident energies from 0.511 to 7.12 MeV. For HPGe and CZT CCs in which all detector effect were included, the DCA was less than 3 mm for 75% and 68% of the detected gammas, respectively, and restricting gammas to those having energy greater than 2.0 MeV increased these percentages to 83% and 77% for HPGe and CZT, respectively. Distributions of the true gamma origins and the PCA after detector characteristics had been included showed good agreement on beam range and some loss of resolution for the lateral profile of the PG emission. Characteristic energy lines were evident in the calculated gamma energy spectrum. Conclusions: The authors found the following: (1) DB is the dominant source of spatial and energy resolution loss in the CCs at all energy levels; (2) the largest difference in the spatial resolution of HPGe and CZT CCs is that the spatial resolution distributions of CZT have broader tails. The differences in the FWHM of these distributions are small; (3) the energy resolution of both HPGe and CZT three-stage CCs is adequate for PG spectroscopy; and (4) restricting the gammas to those having energy greater than 2.0 MeV can improve the achievable image resolution. PMID:23298111

Renal Scintigraphy

MedlinePlus

... in your hand or arm. When it is time for the imaging to begin, the gamma camera will take a series of images. The camera may rotate around you or it may stay in one position and you will be asked to change positions in ... to remain still for brief periods of time. You may be asked to sit or lie ...

Molecular Imaging in the College of Optical Sciences – An Overview of Two Decades of Instrumentation Development

PubMed Central

Furenlid, Lars R.; Barrett, Harrison H.; Barber, H. Bradford; Clarkson, Eric W.; Kupinski, Matthew A.; Liu, Zhonglin; Stevenson, Gail D.; Woolfenden, James M.

2015-01-01

During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon. PMID:26236069

MONICA: A Compact, Portable Dual Gamma Camera System for Mouse Whole-Body Imaging

PubMed Central

Xi, Wenze; Seidel, Jurgen; Karkareka, John W.; Pohida, Thomas J.; Milenic, Diane E.; Proffitt, James; Majewski, Stan; Weisenberger, Andrew G.; Green, Michael V.; Choyke, Peter L.

2009-01-01

Introduction We describe a compact, portable dual-gamma camera system (named “MONICA” for MObile Nuclear Imaging CAmeras) for visualizing and analyzing the whole-body biodistribution of putative diagnostic and therapeutic single photon emitting radiotracers in animals the size of mice. Methods Two identical, miniature pixelated NaI(Tl) gamma cameras were fabricated and installed “looking up” through the tabletop of a compact portable cart. Mice are placed directly on the tabletop for imaging. Camera imaging performance was evaluated with phantoms and field performance was evaluated in a weeklong In-111 imaging study performed in a mouse tumor xenograft model. Results Tc-99m performance measurements, using a photopeak energy window of 140 keV ± 10%, yielded the following results: spatial resolution (FWHM at 1-cm), 2.2-mm; sensitivity, 149 cps/MBq (5.5 cps/μCi); energy resolution (FWHM), 10.8%; count rate linearity (count rate vs. activity), r2 = 0.99 for 0–185 MBq (0–5 mCi) in the field-of-view (FOV); spatial uniformity, < 3% count rate variation across the FOV. Tumor and whole-body distributions of the In-111 agent were well visualized in all animals in 5-minute images acquired throughout the 168-hour study period. Conclusion Performance measurements indicate that MONICA is well suited to whole-body single photon mouse imaging. The field study suggests that inter-device communications and user-oriented interfaces included in the MONICA design facilitate use of the system in practice. We believe that MONICA may be particularly useful early in the (cancer) drug development cycle where basic whole-body biodistribution data can direct future development of the agent under study and where logistical factors, e.g. limited imaging space, portability, and, potentially, cost are important. PMID:20346864

[Nuclear medicine diagnosis of pulmonary capillary protein leakage].

PubMed

Creutzig, H; Sturm, J A; Schober, O; Nerlich, M L; Kant, C J

1984-10-01

Pulmonary extravascular albumin extravasation in patients with adult respiratory distress syndrome can be quantified with radionuclide techniques. While imaging procedures with a computerized gamma camera will allow reproducible ROIs, this will be the main limitation in nonimaging measurements with small scintillation probes. Repeated positioning by one operator results in a mean spatial variation of position of about 2 cm and a variation in count rate of 25%. For the estimation of PCPL the small probes must be positioned under scintigraphic control. Under these conditions the results of both techniques are identical. The upper limit of normal was estimated to be 1 x E-5/sec. The standard deviation of abnormal measurements was about 10%. The pulmonary capillary protein leakage can be quantified by radionuclide techniques with good accuracy, using the combination of imaging and nonimaging techniques.

Semiconductor radiation detector with internal gain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iwanczyk, Jan; Patt, Bradley E.; Vilkelis, Gintas

An avalanche drift photodetector (ADP) incorporates extremely low capacitance of a silicon drift photodetector (SDP) and internal gain that mitigates the surface leakage current noise of an avalanche photodetector (APD). The ADP can be coupled with scintillators such as CsI(Tl), NaI(Tl), LSO or others to form large volume scintillation type gamma ray detectors for gamma ray spectroscopy, photon counting, gamma ray counting, etc. Arrays of the ADPs can be used to replace the photomultiplier tubes (PMTs) used in conjunction with scintillation crystals in conventional gamma cameras for nuclear medical imaging.

Inspection and Gamma-Ray Dose Rate Measurements of the Annulus of the VSC-17 Concrete Spent Nuclear Fuel Storage Cask

DOE Office of Scientific and Technical Information (OSTI.GOV)

P. L. Winston

2007-09-01

The air cooling annulus of the Ventilated Storage Cask (VSC)-17 spent fuel storage cask was inspected using a Toshiba 7 mm (1/4”) CCD video camera. The dose rates observed in the annular space were measured to provide a reference for the activity to which the camera(s) being tested were being exposed. No gross degradation, pitting, or general corrosion was observed.

High-Resolution Scintimammography: A Pilot Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rachel F. Brem; Joelle M. Schoonjans; Douglas A. Kieper

2002-07-01

This study evaluated a novel high-resolution breast-specific gamma camera (HRBGC) for the detection of suggestive breast lesions. Methods: Fifty patients (with 58 breast lesions) for whom a scintimammogram was clinically indicated were prospectively evaluated with a general-purpose gamma camera and a novel HRBGC prototype. The results of conventional and high-resolution nuclear studies were prospectively classified as negative (normal or benign) or positive (suggestive or malignant) by 2 radiologists who were unaware of the mammographic and histologic results. All of the included lesions were confirmed by pathology. Results: There were 30 benign and 28 malignant lesions. The sensitivity for detection ofmore » breast cancer was 64.3% (18/28) with the conventional camera and 78.6% (22/28) with the HRBGC. The specificity with both systems was 93.3% (28/30). For the 18 nonpalpable lesions, sensitivity was 55.5% (10/18) and 72.2% (13/18) with the general-purpose camera and the HRBGC, respectively. For lesions 1 cm, 7 of 15 were detected with the general-purpose camera and 10 of 15 with the HRBGC. Four lesions (median size, 8.5 mm) were detected only with the HRBGC and were missed by the conventional camera. Conclusion: Evaluation of indeterminate breast lesions with an HRBGC results in improved sensitivity for the detection of cancer, with greater improvement shown for nonpalpable and 1-cm lesions.« less

Qualification Tests of Micro-camera Modules for Space Applications

NASA Astrophysics Data System (ADS)

Kimura, Shinichi; Miyasaka, Akira

Visual capability is very important for space-based activities, for which small, low-cost space cameras are desired. Although cameras for terrestrial applications are continually being improved, little progress has been made on cameras used in space, which must be extremely robust to withstand harsh environments. This study focuses on commercial off-the-shelf (COTS) CMOS digital cameras because they are very small and are based on an established mass-market technology. Radiation and ultrahigh-vacuum tests were conducted on a small COTS camera that weighs less than 100 mg (including optics). This paper presents the results of the qualification tests for COTS cameras and for a small, low-cost COTS-based space camera.

Temporal Imaging CeBr3 Compton Camera: A New Concept for Nuclear Decommissioning and Nuclear Waste Management

NASA Astrophysics Data System (ADS)

Iltis, A.; Snoussi, H.; Magalhaes, L. Rodrigues de; Hmissi, M. Z.; Zafiarifety, C. Tata; Tadonkeng, G. Zeufack; Morel, C.

2018-01-01

During nuclear decommissioning or waste management operations, a camera that could make an image of the contamination field and identify and quantify the contaminants would be a great progress. Compton cameras have been proposed, but their limited efficiency for high energy gamma rays and their cost have severely limited their application. Our objective is to promote a Compton camera for the energy range (200 keV - 2 MeV) that uses fast scintillating crystals and a new concept for locating scintillation event: Temporal Imaging. Temporal Imaging uses monolithic plates of fast scintillators and measures photons time of arrival distribution in order to locate each gamma ray with a high precision in space (X,Y,Z), time (T) and energy (E). This provides a native estimation of the depth of interaction (Z) of every detected gamma ray. This also allows a time correction for the propagation time of scintillation photons inside the crystal, therefore resulting in excellent time resolution. The high temporal resolution of the system makes it possible to veto quite efficiently background by using narrow time coincidence (< 300 ps). It is also possible to reconstruct the direction of propagation of the photons inside the detector using timing constraints. The sensitivity of our system is better than 1 nSv/h in a 60 s acquisition with a 22Na source. The project TEMPORAL is funded by the ANDRA/PAI under the grant No. RTSCNADAA160019.

Design of Dual-Road Transportable Portal Monitoring System for Visible Light and Gamma-Ray Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karnowski, Thomas Paul; Cunningham, Mark F; Goddard Jr, James Samuel

2010-01-01

The use of radiation sensors as portal monitors is increasing due to heightened concerns over the smuggling of fissile material. Transportable systems that can detect significant quantities of fissile material that might be present in vehicular traffic are of particular interest, especially if they can be rapidly deployed to different locations. To serve this application, we have constructed a rapid-deployment portal monitor that uses visible-light and gamma-ray imaging to allow simultaneous monitoring of multiple lanes of traffic from the side of a roadway. The system operation uses machine vision methods on the visible-light images to detect vehicles as they entermore » and exit the field of view and to measure their position in each frame. The visible-light and gamma-ray cameras are synchronized which allows the gamma-ray imager to harvest gamma-ray data specific to each vehicle, integrating its radiation signature for the entire time that it is in the field of view. Thus our system creates vehicle-specific radiation signatures and avoids source confusion problems that plague non-imaging approaches to the same problem. Our current prototype instrument was designed for measurement of upto five lanes of freeway traffic with a pair of instruments, one on either side of the roadway. Stereoscopic cameras are used with a third alignment camera for motion compensation and are mounted on a 50 deployable mast. In this paper we discuss the design considerations for the machine-vision system, the algorithms used for vehicle detection and position estimates, and the overall architecture of the system. We also discuss system calibration for rapid deployment. We conclude with notes on preliminary performance and deployment.« less

Design of dual-road transportable portal monitoring system for visible light and gamma-ray imaging

NASA Astrophysics Data System (ADS)

Karnowski, Thomas P.; Cunningham, Mark F.; Goddard, James S.; Cheriyadat, Anil M.; Hornback, Donald E.; Fabris, Lorenzo; Kerekes, Ryan A.; Ziock, Klaus-Peter; Bradley, E. Craig; Chesser, J.; Marchant, W.

2010-04-01

The use of radiation sensors as portal monitors is increasing due to heightened concerns over the smuggling of fissile material. Transportable systems that can detect significant quantities of fissile material that might be present in vehicular traffic are of particular interest, especially if they can be rapidly deployed to different locations. To serve this application, we have constructed a rapid-deployment portal monitor that uses visible-light and gamma-ray imaging to allow simultaneous monitoring of multiple lanes of traffic from the side of a roadway. The system operation uses machine vision methods on the visible-light images to detect vehicles as they enter and exit the field of view and to measure their position in each frame. The visible-light and gamma-ray cameras are synchronized which allows the gamma-ray imager to harvest gamma-ray data specific to each vehicle, integrating its radiation signature for the entire time that it is in the field of view. Thus our system creates vehicle-specific radiation signatures and avoids source confusion problems that plague non-imaging approaches to the same problem. Our current prototype instrument was designed for measurement of upto five lanes of freeway traffic with a pair of instruments, one on either side of the roadway. Stereoscopic cameras are used with a third "alignment" camera for motion compensation and are mounted on a 50' deployable mast. In this paper we discuss the design considerations for the machine-vision system, the algorithms used for vehicle detection and position estimates, and the overall architecture of the system. We also discuss system calibration for rapid deployment. We conclude with notes on preliminary performance and deployment.

Real-time proton beam range monitoring by means of prompt-gamma detection with a collimated camera

NASA Astrophysics Data System (ADS)

Roellinghoff, F.; Benilov, A.; Dauvergne, D.; Dedes, G.; Freud, N.; Janssens, G.; Krimmer, J.; Létang, J. M.; Pinto, M.; Prieels, D.; Ray, C.; Smeets, J.; Stichelbaut, F.; Testa, E.

2014-03-01

Prompt-gamma profile was measured at WPE-Essen using 160 MeV protons impinging a movable PMMA target. A single collimated detector was used with time-of-flight (TOF) to reduce the background due to neutrons. The target entrance rise and the Bragg peak falloff retrieval precision was determined as a function of incident proton number by a fitting procedure using independent data sets. Assuming improved sensitivity of this camera design by using a greater number of detectors, retrieval precisions of 1 to 2 mm (rms) are expected for a clinical pencil beam. TOF improves the contrast-to-noise ratio and the performance of the method significantly.

GCT, the Gamma-ray Cherenkov Telescope for multi-TeV science with the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Sol, H.; Dournaux, J.-L.; Laporte, P.

2016-12-01

GCT is a gamma-ray telescope proposed for the high-energy section of the Cherenkov Telescope Array (CTA). A GCT prototype telescope has been designed, built and installed at the Observatoire de Paris in Meudon. Equipped with the first GCT prototype camera developed by an international collaboration, the complete GCT prototype was inaugurated in December 2015, after getting its first Cherenkov light on the night sky in November. The phase of tests, assessment, and optimisation is now coming to an end. Pre-production of the first GCT telescopes and cameras should start in 2017, for an installation on the Chilean site of CTA in 2018.

Improved neutron-gamma discrimination for a 6Li-glass neutron detector using digital signal analysis methods

DOE PAGES

Wang, Cai -Lin; Riedel, Richard A.

2016-01-14

A 6Li-glass scintillator (GS20) based neutron Anger camera was developed for time-of-flight single-crystal diffraction instruments at SNS. Traditional pulse-height analysis (PHA) for neutron-gamma discrimination (NGD) resulted in the neutron-gamma efficiency ratio (defined as NGD ratio) on the order of 10 4. The NGD ratios of Anger cameras need to be improved for broader applications including neutron reflectometers. For this purpose, five digital signal analysis methods of individual waveforms from PMTs were proposed using: i). pulse-amplitude histogram; ii). power spectrum analysis combined with the maximum pulse amplitude; iii). two event parameters (a 1, b 0) obtained from Wiener filter; iv). anmore » effective amplitude (m) obtained from an adaptive least-mean-square (LMS) filter; and v). a cross-correlation (CC) coefficient between an individual waveform and a reference. The NGD ratios can be 1-102 times those from traditional PHA method. A brighter scintillator GS2 has better NGD ratio than GS20, but lower neutron detection efficiency. The ultimate NGD ratio is related to the ambient, high-energy background events. Moreover, our results indicate the NGD capability of neutron Anger cameras can be improved using digital signal analysis methods and brighter neutron scintillators.« less

The upgrade of the H.E.S.S. cameras

NASA Astrophysics Data System (ADS)

Giavitto, Gianluca; Ashton, Terry; Balzer, Arnim; Berge, David; Brun, Francois; Chaminade, Thomas; Delagnes, Eric; Fontaine, Gerard; Füßling, Matthias; Giebels, Berrie; Glicenstein, Jean-Francois; Gräber, Tobias; Hinton, Jim; Jahnke, Albert; Klepser, Stefan; Kossatz, Marko; Kretzschmann, Axel; Lefranc, Valentin; Leich, Holger; Lüdecke, Hartmut; Lypova, Iryna; Manigot, Pascal; Marandon, Vincent; Moulin, Emmanuel; Naurois, Mathieu de; Nayman, Patrick; Ohm, Stefan; Penno, Marek; Ross, Duncan; Salek, David; Schade, Markus; Schwab, Thomas; Simoni, Rachel; Stegmann, Christian; Steppa, Constantin; Thornhill, Julian; Toussnel, Francois

2017-12-01

The High Energy Stereoscopic System (HESS) is an array of imaging atmospheric Cherenkov telescopes (IACTs) located in the Khomas highland in Namibia. It was built to detect Very High Energy (VHE > 100 GeV) cosmic gamma rays. Since 2003, HESS has discovered the majority of the known astrophysical VHE gamma-ray sources, opening a new observational window on the extreme non-thermal processes at work in our universe. HESS consists of four 12-m diameter Cherenkov telescopes (CT1-4), which started data taking in 2002, and a larger 28-m telescope (CT5), built in 2012, which lowers the energy threshold of the array to 30 GeV . The cameras of CT1-4 are currently undergoing an extensive upgrade, with the goals of reducing their failure rate, reducing their readout dead time and improving the overall performance of the array. The entire camera electronics has been renewed from ground-up, as well as the power, ventilation and pneumatics systems, and the control and data acquisition software. Only the PMTs and their HV supplies have been kept from the original cameras. Novel technical solutions have been introduced, which will find their way into some of the Cherenkov cameras foreseen for the next-generation Cherenkov Telescope Array (CTA) observatory. In particular, the camera readout system is the first large-scale system based on the analog memory chip NECTAr, which was designed for CTA cameras. The camera control subsystems and the control software framework also pursue an innovative design, exploiting cutting-edge hardware and software solutions which excel in performance, robustness and flexibility. The CT1 camera has been upgraded in July 2015 and is currently taking data; CT2-4 have been upgraded in fall 2016. Together they will assure continuous operation of HESS at its full sensitivity until and possibly beyond the advent of CTA. This contribution describes the design, the testing and the in-lab and on-site performance of all components of the newly upgraded HESS camera.

SU-F-J-182: Investigation of Systems for Improved Accuracy in Clinical Y-90 Percent Delivered Calculations

DOE Office of Scientific and Technical Information (OSTI.GOV)

McBeth, R; Elder, D; Kesner, A

2016-06-15

Purpose: Y-90 Selective Internal Radiation Therapy (SIRT) is used to treat liver tumors, and by nature has variability in the percent of the intended dose that is actually delivered. To determine the quality of the administration, pre and post activity measurements are taken, and used to infer percent delivered. Vendor specifications indicate the use of an ion chamber to take these measurements. In our work, we investigated the accuracy of ion chambers, and compared them to other detector systems. Methods: We have built phantoms, phantom holders, and protocols, which allow us to measure our Y90 doses with varying apparatuses: amore » dose calibrator, a Geiger-counter, an ion chamber, a crystal based thyroid probe, and a gamma camera. We have set up a system that has enabled us to gather data by measuring clinical Y90 doses as they are used in the clinic using all of the instrumental methods. Five initial doses (25 measurements/acquisitions) have been taken at the time of this abstract submission. Results: Our initial results show that measurements acquired using scintillation based detectors (thyroid probe and gamma camera) correlate better with the gold standard (i.e. the dose calibrator). Pearson correlations between the dose calibrator measurements and the GM counter, Ion chamber, thyroid probe, and gamma camera were found to be 0.88, 0.83, 0.98, 0.99, respectively. More acquisitions and analysis are planned to determine the precision of the systems, as well as optimal energy window settings. Conclusion: It is likely that current standard practice can be improved using scintillation crystal based detectors. Such systems are more sensitive, can integrate signal, and can use energy discrimination. Furthermore, phantoms can be built to integrate with probe and gamma camera systems that are robust and provide reproducibility. Future work will include expanded acquisition and analysis.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turkington, T.

This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Bemore » able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT images for SPECT reconstructions. Become knowledgeable of items to be included in annual acceptance testing reports including CT dosimetry and PACS monitor measurements. T. Turkington, GE Healthcare.« less

TU-H-206-01: An Automated Approach for Identifying Geometric Distortions in Gamma Cameras

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mann, S; Nelson, J; Samei, E

2016-06-15

Purpose: To develop a clinically-deployable, automated process for detecting artifacts in routine nuclear medicine (NM) quality assurance (QA) bar phantom images. Methods: An artifact detection algorithm was created to analyze bar phantom images as part of an ongoing QA program. A low noise, high resolution reference image was acquired from an x-ray of the bar phantom with a Philips Digital Diagnost system utilizing image stitching. NM bar images, acquired for 5 million counts over a 512×512 matrix, were registered to the template image by maximizing mutual information (MI). The MI index was used as an initial test for artifacts; lowmore » values indicate an overall presence of distortions regardless of their spatial location. Images with low MI scores were further analyzed for bar linearity, periodicity, alignment, and compression to locate differences with respect to the template. Findings from each test were spatially correlated and locations failing multiple tests were flagged as potential artifacts requiring additional visual analysis. The algorithm was initially deployed for GE Discovery 670 and Infinia Hawkeye gamma cameras. Results: The algorithm successfully identified clinically relevant artifacts from both systems previously unnoticed by technologists performing the QA. Average MI indices for artifact-free images are 0.55. Images with MI indices < 0.50 have shown 100% sensitivity and specificity for artifact detection when compared with a thorough visual analysis. Correlation of geometric tests confirms the ability to spatially locate the most likely image regions containing an artifact regardless of initial phantom orientation. Conclusion: The algorithm shows the potential to detect gamma camera artifacts that may be missed by routine technologist inspections. Detection and subsequent correction of artifacts ensures maximum image quality and may help to identify failing hardware before it impacts clinical workflow. Going forward, the algorithm is being deployed to monitor data from all gamma cameras within our health system.« less

Simulation based evaluation of the designs of the Advanced Gamma-ray Imageing System (AGIS)

NASA Astrophysics Data System (ADS)

Bugaev, Slava; Buckley, James; Digel, Seth; Funk, Stephen; Konopelko, Alex; Krawczynski, Henric; Lebohec, Steohan; Maier, Gernot; Vassiliev, Vladimir

2009-05-01

The AGIS project under design study, is a large array of imaging atmospheric Cherenkov telescopes for gamma-rays astronomy between 40GeV and 100 TeV. In this paper we present the ongoing simulation effort to model the considered design approaches as a function of the main parameters such as array geometry, telescope optics and camera design in such a way the gamma ray observation capabilities can be optimized against the overall project cost.

Inversion of the conical Radon transform with vertices on a surface of revolution arising in an application of a Compton camera

NASA Astrophysics Data System (ADS)

Moon, Sunghwan

2017-06-01

A Compton camera has been introduced for use in single photon emission computed tomography to improve the low efficiency of a conventional gamma camera. In general, a Compton camera brings about the conical Radon transform. Here we consider a conical Radon transform with the vertices on a rotation symmetric set with respect to a coordinate axis. We show that this conical Radon transform can be decomposed into two transforms: the spherical sectional transform and the weighted fan beam transform. After finding inversion formulas for these two transforms, we provide an inversion formula for the conical Radon transform.

Radionuclides in Diagnosis.

ERIC Educational Resources Information Center

Williams, E. D.

1989-01-01

Discussed is a radionuclide imaging technique, including the gamma camera, image analysis computer, radiopharmaceuticals, and positron emission tomography. Several pictures showing the use of this technique are presented. (YP)

Impact of an external radiation field on handheld XRF measurements for nuclear forensics applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steeb, Jennifer L.; Mertz, Carol J.; Finck, Martha R.

X-ray fluorescence (XRF) is an attractive technique for nuclear forensics applications. We evaluated a handheld, portable XRF device by applying an external radiation field (10 mR/h to 17 R/h) using two types of radiography sources: a 60Co radiography camera to observe effects from high-energy gamma emissions and an 192Ir radiography camera to observe effects from several low-energy gamma (0.604, 0.468, and 0.317 MeV) and decay daughter x-ray emissions. External radiation tests proved that radiation, in general, has a significant effect on the dead time or background at dose rates over 1 R/hr for both the 192Ir and 60Co sources.

Studies on a silicon-photomultiplier-based camera for Imaging Atmospheric Cherenkov Telescopes

NASA Astrophysics Data System (ADS)

Arcaro, C.; Corti, D.; De Angelis, A.; Doro, M.; Manea, C.; Mariotti, M.; Rando, R.; Reichardt, I.; Tescaro, D.

2017-12-01

Imaging Atmospheric Cherenkov Telescopes (IACTs) represent a class of instruments which are dedicated to the ground-based observation of cosmic VHE gamma ray emission based on the detection of the Cherenkov radiation produced in the interaction of gamma rays with the Earth atmosphere. One of the key elements of such instruments is a pixelized focal-plane camera consisting of photodetectors. To date, photomultiplier tubes (PMTs) have been the common choice given their high photon detection efficiency (PDE) and fast time response. Recently, silicon photomultipliers (SiPMs) are emerging as an alternative. This rapidly evolving technology has strong potential to become superior to that based on PMTs in terms of PDE, which would further improve the sensitivity of IACTs, and see a price reduction per square millimeter of detector area. We are working to develop a SiPM-based module for the focal-plane cameras of the MAGIC telescopes to probe this technology for IACTs with large focal plane cameras of an area of few square meters. We will describe the solutions we are exploring in order to balance a competitive performance with a minimal impact on the overall MAGIC camera design using ray tracing simulations. We further present a comparative study of the overall light throughput based on Monte Carlo simulations and considering the properties of the major hardware elements of an IACT.

NEUTRON RADIATION DAMAGE IN CCD CAMERAS AT JOINT EUROPEAN TORUS (JET).

PubMed

Milocco, Alberto; Conroy, Sean; Popovichev, Sergey; Sergienko, Gennady; Huber, Alexander

2017-10-26

The neutron and gamma radiations in large fusion reactors are responsible for damage to charged couple device (CCD) cameras deployed for applied diagnostics. Based on the ASTM guide E722-09, the 'equivalent 1 MeV neutron fluence in silicon' was calculated for a set of CCD cameras at the Joint European Torus. Such evaluations would be useful to good practice in the operation of the video systems. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Compton camera study for high efficiency SPECT and benchmark with Anger system

NASA Astrophysics Data System (ADS)

Fontana, M.; Dauvergne, D.; Létang, J. M.; Ley, J.-L.; Testa, É.

2017-12-01

Single photon emission computed tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. The clinical routine is mostly based on collimated cameras, originally proposed by Hal Anger. Due to the presence of mechanical collimation, detection efficiency and energy acceptance are limited and fixed by the system’s geometrical features. In order to overcome these limitations, the application of Compton cameras for SPECT has been investigated for several years. In this study we compare a commercial SPECT-Anger device, the General Electric HealthCare Infinia system with a High Energy General Purpose (HEGP) collimator, and the Compton camera prototype under development by the French collaboration CLaRyS, through Monte Carlo simulations (GATE—GEANT4 Application for Tomographic Emission—version 7.1 and GEANT4 version 9.6, respectively). Given the possible introduction of new radio-emitters at higher energies intrinsically allowed by the Compton camera detection principle, the two detectors are exposed to point-like sources at increasing primary gamma energies, from actual isotopes already suggested for nuclear medicine applications. The Compton camera prototype is first characterized for SPECT application by studying the main parameters affecting its imaging performance: detector energy resolution and random coincidence rate. The two detector performances are then compared in terms of radial event distribution, detection efficiency and final image, obtained by gamma transmission analysis for the Anger system, and with an iterative List Mode-Maximum Likelihood Expectation Maximization (LM-MLEM) algorithm for the Compton reconstruction. The results show for the Compton camera a detection efficiency increased by a factor larger than an order of magnitude with respect to the Anger camera, associated with an enhanced spatial resolution for energies beyond 500 keV. We discuss the advantages of Compton camera application for SPECT if compared to present commercial Anger systems, with particular focus on dose delivered to the patient, examination time, and spatial uncertainties.

Directional Unfolded Source Term (DUST) for Compton Cameras.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Dean J.; Horne, Steven M.; O'Brien, Sean

2018-03-01

A Directional Unfolded Source Term (DUST) algorithm was developed to enable improved spectral analysis capabilities using data collected by Compton cameras. Achieving this objective required modification of the detector response function in the Gamma Detector Response and Analysis Software (GADRAS). Experimental data that were collected in support of this work include measurements of calibration sources at a range of separation distances and cylindrical depleted uranium castings.

IR observations in gamma-ray blazars

NASA Technical Reports Server (NTRS)

Mahoney, W. A.; Gautier, T. N.; Ressler, M. E.; Wallyn, P.; Durouchoux, P.; Higdon, J. C.

1997-01-01

The infrared photometric and spectral observation of five gamma ray blazars in coordination with the energetic gamma ray experiment telescope (EGRET) onboard the Compton Gamma Ray Observatory is reported. The infrared measurements were made with a Cassegrain infrared camera and the mid-infrared large well imager at the Mt. Palomar 5 m telescope. The emphasis is on the three blazars observed simultaneously by EGRET and the ground-based telescope during viewing period 519. In addition to the acquisition of broadband spectral measurements for direct correlation with the 100 MeV EGRET observations, near infrared images were obtained, enabling a search for intra-day variability to be carried out.

Prototype AEGIS: A Pixel-Array Readout Circuit for Gamma-Ray Imaging.

PubMed

Barber, H Bradford; Augustine, F L; Furenlid, L; Ingram, C M; Grim, G P

2005-07-31

Semiconductor detector arrays made of CdTe/CdZnTe are expected to be the main components of future high-performance, clinical nuclear medicine imaging systems. Such systems will require small pixel-pitch and much larger numbers of pixels than are available in current semiconductor-detector cameras. We describe the motivation for developing a new readout integrated circuit, AEGIS, for use in hybrid semiconductor detector arrays, that may help spur the development of future cameras. A basic design for AEGIS is presented together with results of an HSPICE ™ simulation of the performance of its unit cell. AEGIS will have a shaper-amplifier unit cell and neighbor pixel readout. Other features include the use of a single input power line with other biases generated on-board, a control register that allows digital control of all thresholds and chip configurations and an output approach that is compatible with list-mode data acquisition. An 8×8 prototype version of AEGIS is currently under development; the full AEGIS will be a 64×64 array with 300 μm pitch.

Toward Simultaneous Real-Time Fluoroscopic and Nuclear Imaging in the Intervention Room.

PubMed

Beijst, Casper; Elschot, Mattijs; Viergever, Max A; de Jong, Hugo W A M

2016-01-01

To investigate the technical feasibility of hybrid simultaneous fluoroscopic and nuclear imaging. An x-ray tube, an x-ray detector, and a gamma camera were positioned in one line, enabling imaging of the same field of view. Since a straightforward combination of these elements would block the lines of view, a gamma camera setup was developed to be able to view around the x-ray tube. A prototype was built by using a mobile C-arm and a gamma camera with a four-pinhole collimator. By using the prototype, test images were acquired and sensitivity, resolution, and coregistration error were analyzed. Nuclear images (two frames per second) were acquired simultaneously with fluoroscopic images. Depending on the distance from point source to detector, the system resolution was 1.5-1.9-cm full width at half maximum, the sensitivity was (0.6-1.5) × 10(-5) counts per decay, and the coregistration error was -0.13 to 0.15 cm. With good spatial and temporal alignment of both modalities throughout the field of view, fluoroscopic images can be shown in grayscale and corresponding nuclear images in color overlay. Measurements obtained with the hybrid imaging prototype device that combines simultaneous fluoroscopic and nuclear imaging of the same field of view have demonstrated the feasibility of real-time simultaneous hybrid imaging in the intervention room. © RSNA, 2015

Intraoperative Imaging Guidance for Sentinel Node Biopsy in Melanoma Using a Mobile Gamma Camera

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dengel, Lynn T; Judy, Patricia G; Petroni, Gina R

2011-04-01

The objective is to evaluate the sensitivity and clinical utility of intraoperative mobile gamma camera (MGC) imaging in sentinel lymph node biopsy (SLNB) in melanoma. The false-negative rate for SLNB for melanoma is approximately 17%, for which failure to identify the sentinel lymph node (SLN) is a major cause. Intraoperative imaging may aid in detection of SLN near the primary site, in ambiguous locations, and after excision of each SLN. The present pilot study reports outcomes with a prototype MGC designed for rapid intraoperative image acquisition. We hypothesized that intraoperative use of the MGC would be feasible and that sensitivitymore » would be at least 90%. From April to September 2008, 20 patients underwent Tc99 sulfur colloid lymphoscintigraphy, and SLNB was performed with use of a conventional fixed gamma camera (FGC), and gamma probe followed by intraoperative MGC imaging. Sensitivity was calculated for each detection method. Intraoperative logistical challenges were scored. Cases in which MGC provided clinical benefit were recorded. Sensitivity for detecting SLN basins was 97% for the FGC and 90% for the MGC. A total of 46 SLN were identified: 32 (70%) were identified as distinct hot spots by preoperative FGC imaging, 31 (67%) by preoperative MGC imaging, and 43 (93%) by MGC imaging pre- or intraoperatively. The gamma probe identified 44 (96%) independent of MGC imaging. The MGC provided defined clinical benefit as an addition to standard practice in 5 (25%) of 20 patients. Mean score for MGC logistic feasibility was 2 on a scale of 1-9 (1 = best). Intraoperative MGC imaging provides additional information when standard techniques fail or are ambiguous. Sensitivity is 90% and can be increased. This pilot study has identified ways to improve the usefulness of an MGC for intraoperative imaging, which holds promise for reducing false negatives of SLNB for melanoma.« less

Septal penetration correction in I-131 imaging following thyroid cancer treatment

NASA Astrophysics Data System (ADS)

Barrack, Fiona; Scuffham, James; McQuaid, Sarah

2018-04-01

Whole body gamma camera images acquired after I-131 treatment for thyroid cancer can suffer from collimator septal penetration artefacts because of the high energy of the gamma photons. This results in the appearance of ‘spoke’ artefacts, emanating from regions of high activity concentration, caused by the non-isotropic attenuation of the collimator. Deconvolution has the potential to reduce such artefacts, by taking into account the non-Gaussian point-spread-function (PSF) of the system. A Richardson–Lucy deconvolution algorithm, with and without prior scatter-correction was tested as a method of reducing septal penetration in planar gamma camera images. Phantom images (hot spheres within a warm background) were acquired and deconvolution using a measured PSF was applied. The results were evaluated through region-of-interest and line profile analysis to determine the success of artefact reduction and the optimal number of deconvolution iterations and damping parameter (λ). Without scatter-correction, the optimal results were obtained with 15 iterations and λ  =  0.01, with the counts in the spokes reduced to 20% of the original value, indicating a substantial decrease in their prominence. When a triple-energy-window scatter-correction was applied prior to deconvolution, the optimal results were obtained with six iterations and λ  =  0.02, which reduced the spoke counts to 3% of the original value. The prior application of scatter-correction therefore produced the best results, with a marked change in the appearance of the images. The optimal settings were then applied to six patient datasets, to demonstrate its utility in the clinical setting. In all datasets, spoke artefacts were substantially reduced after the application of scatter-correction and deconvolution, with the mean spoke count being reduced to 10% of the original value. This indicates that deconvolution is a promising technique for septal penetration artefact reduction that could potentially improve the diagnostic accuracy of I-131 imaging. Novelty and significance This work has demonstrated that scatter correction combined with deconvolution can be used to substantially reduce the appearance of septal penetration artefacts in I-131 phantom and patient gamma camera planar images, enable improved visualisation of the I-131 distribution. Deconvolution with symmetric PSF has previously been used to reduce artefacts in gamma camera images however this work details the novel use of an asymmetric PSF to remove the angularly dependent septal penetration artefacts.

A restraint-free small animal SPECT imaging system with motion tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weisenberger, A.G.; Gleason, S.S.; Goddard, J.

2005-06-01

We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels whilemore » retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction.« less

Our solution for fusion of simultaneusly acquired whole body scintigrams and optical images, as usesful tool in clinical practice in patients with differentiated thyroid carcinomas after radioiodine therapy. A useful tool in clinical practice.

PubMed

Matovic, Milovan; Jankovic, Milica; Barjaktarovic, Marko; Jeremic, Marija

2017-01-01

After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras. For image acquisition in the gamma part of the spectra we used e.cam dual head gamma camera (Siemens, Erlangen, Germany) in WBS modality, with matrix size of 256×1024 pixels and bed speed of 6cm/min, equipped with high energy collimator. For optical image acquisition in visible part of spectra we have used web-camera model C905 (Logitech, USA) with Carl Zeiss® optics, native resolution 1600×1200 pixels, 34 o field of view, 30g weight, with autofocus option turned "off" and auto white balance turned "on". Web camera is connected to upper head of gamma camera (GC) by a holder of lightweight aluminum rod and a plexiglas adapter. Our own Vision-Fusion software for image acquisition and coregistration was developed using NI LabVIEW programming environment 2015 (National Instruments, Texas, USA) and two additional LabVIEW modules: NI Vision Acquisition Software (VAS) and NI Vision Development Module (VDM). Vision acquisition software enables communication and control between laptop computer and web-camera. Vision development module is image processing library used for image preprocessing and fusion. Software starts the web-camera image acquisition before starting image acquisition on GC and stops it when GC completes the acquisition. Web-camera is in continuous acquisition mode with frame rate f depending on speed of patient bed movement v (f=v/∆ cm , where ∆ cm is a displacement step that can be changed in Settings option of Vision-Fusion software; by default, ∆ cm is set to 1cm corresponding to ∆ p =15 pixels). All images captured while patient's bed is moving are processed. Movement of patient's bed is checked using cross-correlation of two successive images. After each image capturing, algorithm extracts the central region of interest (ROI) of the image, with the same width as captured image (1600 pixels) and the height that is equal to the ∆ p displacement in pixels. All extracted central ROI are placed next to each other in the overall whole-body image. Stacking of narrow central ROI introduces negligible distortion in the overall whole-body image. The first step for fusion of the scintigram and the optical image was determination of spatial transformation between them. We have made an experiment with two markers (point radioactivity sources of 99m Tc pertechnetate 1MBq) visible in both images (WBS and optical) to find transformation of coordinates between images. The distance between point markers is used for spatial coregistration of the gamma and optical images. At the end of coregistration process, gamma image is rescaled in spatial domain and added to the optical image (green or red channel, amplification changeable from user interface). We tested our system for 10 patients with DTC who received radioiodine therapy (8 women and two men, with average age of 50.10±12.26 years). Five patients received 5.55Gbq, three 3.70GBq and two 1.85GBq. Whole-body scintigraphy and optical image acquisition were performed 72 hours after application of radioiodine therapy. Based on our first results during clinical testing of our system, we can conclude that our system can improve diagnostic possibility of whole body scintigraphy to detect thyroid remnant tissue in patients with DTC after radioiodine therapy.

The effect of guar gum and fiber-enriched wheat bran on gastric emptying of a semisolid meal in healthy subjects.

PubMed

Rydning, A; Berstad, A; Berstad, T; Hertzenberg, L

1985-04-01

The effect of physiological doses of guar gum (Guarem), 5 g, and fiber-enriched wheat bran (Fiberform), 10.5 g, on gastric emptying was studied by two different methods in healthy subjects: by a simple isotope localization monitor placed over the upper part of the abdomen and by gamma camera. The fiber preparations were added to a semisolid meal consisting of wheatmeal porridge and juice, using technetium-99 DTPA as a marker. The gamma camera showed no effect of fiber on gastric emptying. The isotope localization monitor, however, indicated that Fiberform prevented a postprandial accumulation of the meal within the upper part of the stomach. The simple isotope localization monitor cannot be recommended for measurements of gastric emptying.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, S; Meredith, R; Azure, M

Purpose: To support the phase I trial for toxicity, biodistribution and pharmacokinetics of intra-peritoneal (IP) 212Pb-TCMC-trastuzumab in patients with HER-2 expressing malignancy. A whole body gamma camera imaging method was developed for estimating amount of 212Pb-TCMC-trastuzumab left in the peritoneal cavity. Methods: {sup 212}Pb decays to {sup 212}Bi via beta emission. {sup 212}Bi emits an alpha particle at an average of 6.1 MeV. The 238.6 keV gamma ray with a 43.6% yield can be exploited for imaging. Initial phantom was made of saline bags with 212Pb. Images were collected for 238.6 keV with a medium energy general purpose collimator. Theremore » are other high energy gamma emissions (e.g. 511keV, 8%; 583 keV, 31%) that penetrate the septae of the collimator and contribute scatter into 238.6 keV. An upper scatter window was used for scatter correction for these high energy gammas. Results: A small source containing 212Pb can be easily visualized. Scatter correction on images of a small 212Pb source resulted in a ∼50% reduction in the full width at tenth maximum (FWTM), while change in full width at half maximum (FWHM) was <10%. For photopeak images, substantial scatter around phantom source extended to > 5 cm outside; scatter correction improved image contrast by removing this scatter around the sources. Patient imaging, in the 1st cohort (n=3) showed little redistribution of 212Pb-TCMC-trastuzumab out of the peritoneal cavity. Compared to the early post-treatment images, the 18-hour post-injection images illustrated the shift to more uniform anterior/posterior abdominal distribution and the loss of intensity due to radioactive decay. Conclusion: Use of medium energy collimator, 15% width of 238.6 keV photopeak, and a 7.5% upper scatter window is adequate for quantification of 212Pb radioactivity inside peritoneal cavity for alpha radioimmunotherapy of ovarian cancer. Research Support: AREVA Med, NIH 1UL1RR025777-01.« less

[Results of the EGRET Detector Program

NASA Technical Reports Server (NTRS)

Carter-Lewis, D. A.

1998-01-01

This NASA grant has funded studies of cosmic objects observed by both the EGRET detector aboard the Compton Gamma-ray Observatory and Whipple Gamma-ray imaging telescope. The former has sensitivity up to a few GeV and latter has sensitivity starting at about 200 GeV extending up to beyond 10 TeV. Thus these instruments probe some of the most energetic phenomena in the universe. This program has been in place for several years and led to important results referred to below. The Whipple Observatory Imaging Cherenkov Telescope consists of a 10-meter reflector with a nanosecond photomultiplier-tube camera at the focal plane. During the time period covered by this grant, it had either 109 pixels or 151 pixels on a 1/4 degree hexagonal pattern. As a TeV gamma ray enters the atmosphere, it produces an electron/positron pair initiating an extensive air shower. Cherenkov light from the electrons and positrons in the shower form an image of the shower at the phototube camera. The shape and intensity of this image is used to distinguish gamma-ray initiated showers from cosmic-ray (largely proton and alpha-particle) background showers and to derive an energy estimate for the primary gamma-ray. The Whipple Observatory gamma-ray collaboration pioneered this imaging technique which normally rejects over 99 percent of the cosmic-ray background while keeping over 70 percent of the gamma-ray signal. One of its key features is 2 large collection area which can exceed 50,000 meters. This grant covered primarily correlated observations of Markarian 421 and observations of the Cygnus region. The former resulted in a multiwavelength campaign showing correlations in several wavebands. The TeV data showed dramatic variability with the emission characterized by day-scale flickering and with now well defined steady component.

Positron emission particle tracking using a modular positron camera

NASA Astrophysics Data System (ADS)

Parker, D. J.; Leadbeater, T. W.; Fan, X.; Hausard, M. N.; Ingram, A.; Yang, Z.

2009-06-01

The technique of positron emission particle tracking (PEPT), developed at Birmingham in the early 1990s, enables a radioactively labelled tracer particle to be accurately tracked as it moves between the detectors of a "positron camera". In 1999 the original Birmingham positron camera, which consisted of a pair of MWPCs, was replaced by a system comprising two NaI(Tl) gamma camera heads operating in coincidence. This system has been successfully used for PEPT studies of a wide range of granular and fluid flow processes. More recently a modular positron camera has been developed using a number of the bismuth germanate (BGO) block detectors from standard PET scanners (CTI ECAT 930 and 950 series). This camera has flexible geometry, is transportable, and is capable of delivering high data rates. This paper presents simple models of its performance, and initial experience of its use in a range of geometries and applications.

Design and realization of an AEC&AGC system for the CCD aerial camera

NASA Astrophysics Data System (ADS)

Liu, Hai ying; Feng, Bing; Wang, Peng; Li, Yan; Wei, Hao yun

2015-08-01

An AEC and AGC(Automatic Exposure Control and Automatic Gain Control) system was designed for a CCD aerial camera with fixed aperture and electronic shutter. The normal AEC and AGE algorithm is not suitable to the aerial camera since the camera always takes high-resolution photographs in high-speed moving. The AEC and AGE system adjusts electronic shutter and camera gain automatically according to the target brightness and the moving speed of the aircraft. An automatic Gamma correction is used before the image is output so that the image is better for watching and analyzing by human eyes. The AEC and AGC system could avoid underexposure, overexposure, or image blurring caused by fast moving or environment vibration. A series of tests proved that the system meet the requirements of the camera system with its fast adjusting speed, high adaptability, high reliability in severe complex environment.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thakur, Gautam

A data-driven realistic design and evalua- tion of vehicular mobility has been particularly chal- lenging due to a lack of large-scale real-world mea- surements in the research community. Current research methodologies rely on articial scenarios, random con- nectivity, and use small and biased samples. In this pa- per, we perform a combined study to learn the struc- ture and connectivity of urban streets and modeling and characterization of vehicular trac densities on them. Our dataset is a collection of more than 222 thousand routes and 25 million vehicular mobility images from 1091 online web cameras located in six dierent re-more » gions of the world. Our results centered around four major observations: i. study shows that driving routes and visiting locations of regions demonstrate power-law distribution, indicating a planned or recently designed road infrastructure; ii. we represent regions by network graphs in which nodes are camera locations and edges are urban streets that connect the nodes. Such represen- tation exhibits small world properties with short path lengths and large clustering coecient; iii. trac densi- ties show 80% temporal correlation during several hours of a day; iv. modeling trac densities against known theoretical distributions show less than 5% deviation for heavy-trailed models such as log-logistic and log- gamma distributions. We believe this work will provide a much-needed contribution to the research community for design and evaluation of future vehicular networks and smart cities.« less

Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design

NASA Astrophysics Data System (ADS)

Lai, Xiaochun; Meng, Ling-Jian

2018-02-01

In this paper, we present simulation studies for the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept. The MRC-SPECT-II system consists of a total of 1536 independent micro-pinhole-camera-elements (MCEs) distributed in a ring with an inner diameter of 6 cm. This system provides a FOV of 1 cm diameter and a peak geometrical efficiency of approximately 1.3% (the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining a sub-500 μm spatial resolution. Compared to the first-generation MRC-SPECT system (MRC-SPECT-I) (Cai 2014 Nucl. Instrum. Methods Phys. Res. A 734 147-51) developed in our lab, the MRC-SPECT-II system offers a similar resolution with dramatically improved sensitivity and greatly reduced physical dimension. The latter should allow the system to be placed inside most clinical and pre-clinical MRI scanners for high-performance simultaneous MRI and SPECT imaging.

Gamma-Ray Imaging for Explosives Detection

NASA Technical Reports Server (NTRS)

deNolfo, G. A.; Hunter, S. D.; Barbier, L. M.; Link, J. T.; Son, S.; Floyd, S. R.; Guardala, N.; Skopec, M.; Stark, B.

2008-01-01

We describe a gamma-ray imaging camera (GIC) for active interrogation of explosives being developed by NASA/GSFC and NSWCICarderock. The GIC is based on the Three-dimensional Track Imager (3-DTI) technology developed at GSFC for gamma-ray astrophysics. The 3-DTI, a large volume time-projection chamber, provides accurate, approx.0.4 mm resolution, 3-D tracking of charged particles. The incident direction of gamma rays, E, > 6 MeV, are reconstructed from the momenta and energies of the electron-positron pair resulting from interactions in the 3-DTI volume. The optimization of the 3-DTI technology for this specific application and the performance of the GIC from laboratory tests is presented.

Breathing synchronized assessment of the chest hemodynamics: application to gamma and MR angiography

NASA Astrophysics Data System (ADS)

Eclancher, Bernard; Demangeat, Jean-Louis; Germain, Philippe; Baruthio, Joseph

2003-05-01

The project was to assess by gamma and MR angiography the bulk variations of chest blood volume related to deep and slow breathing movements. The acquisitions were performed at constant intervals on the widely moving system, without cardiac gating. Two fast enough modalities were used: a gamma-stethoscope working at 30 msec intervals for bulk volumic detection (of 99Tc labelled red cells), and MR imaging at 0.5 sec intervals well depicting displacements but not yet performing true angiography. The third modality yielding quantitative imaging was the scintillation gamma camera, but which required 30 sec signal acquisitions for each image. Frames were acquired at 1 sec intervals for up to 30 breathing cycles, and later sorted with double (inspiration and expiration) synchronization for the reconstruction of an average breathing cycle. Convergent results were obtained from the three angiographic modalities, confirming that the deep breathing movements produced inspiratory increases in bulk blood volume and caudal-median displacement of heart and great vessels, and expiratory decreases in blood volume and cranial-left displacement of heart and great vessels. Deep and slow breathing contributed effectively to thoracic blood pumping. The design of a 64x64 channels collimator has been undertaken to speed up the scintillation camera imaging acquisitions.

Soft gamma-ray detector for the ASTRO-H Mission

NASA Astrophysics Data System (ADS)

Watanabe, Shin; Tajima, Hiroyasu; Fukazawa, Yasushi; Blandford, Roger; Enoto, Teruaki; Kataoka, Jun; Kawaharada, Madoka; Kokubun, Motohide; Laurent, Philippe; Lebrun, François; Limousin, Olivier; Madejski, Greg; Makishima, Kazuo; Mizuno, Tsunefumi; Nakamori, Takeshi; Nakazawa, Kazuhiro; Mori, Kunishiro; Odaka, Hirokazu; Ohno, Masanori; Ohta, Masayuki; Sato, Goro; Sato, Rie; Takeda, Shin'ichiro; Takahashi, Hiromitsu; Takahashi, Tadayuki; Tanaka, Takaaki; Tashiro, Makoto; Terada, Yukikatsu; Uchiyama, Hideki; Uchiyama, Yasunobu; Yamada, Shinya; Yatsu, Yoichi; Yonetoku, Daisuke; Yuasa, Takayuki

2012-09-01

ASTRO-H is the next generation JAXA X-ray satellite, intended to carry instruments with broad energy coverage and exquisite energy resolution. The Soft Gamma-ray Detector (SGD) is one of ASTRO-H instruments and will feature wide energy band (60-600 keV) at a background level 10 times better than the current instruments on orbit. The SGD is complimentary to ASTRO-H’s Hard X-ray Imager covering the energy range of 5-80 keV. The SGD achieves low background by combining a Compton camera scheme with a narrow field-of-view active shield where Compton kinematics is utilized to reject backgrounds. The Compton camera in the SGD is realized as a hybrid semiconductor detector system which consists of silicon and CdTe (cadmium telluride) sensors. Good energy resolution is afforded by semiconductor sensors, and it results in good background rejection capability due to better constraints on Compton kinematics. Utilization of Compton kinematics also makes the SGD sensitive to the gamma-ray polarization, opening up a new window to study properties of gamma-ray emission processes. In this paper, we will present the detailed design of the SGD and the results of the final prototype developments and evaluations. Moreover, we will also present expected performance based on the measurements with prototypes.

MO-AB-206-00: Nuclear Medicine Physics and Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Bemore » able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT images for SPECT reconstructions. Become knowledgeable of items to be included in annual acceptance testing reports including CT dosimetry and PACS monitor measurements. T. Turkington, GE Healthcare.« less

Concept of a photon-counting camera based on a diffraction-addressed Gray-code mask

NASA Astrophysics Data System (ADS)

Morel, Sébastien

2004-09-01

A new concept of photon counting camera for fast and low-light-level imaging applications is introduced. The possible spectrum covered by this camera ranges from visible light to gamma rays, depending on the device used to transform an incoming photon into a burst of visible photons (photo-event spot) localized in an (x,y) image plane. It is actually an evolution of the existing "PAPA" (Precision Analog Photon Address) Camera that was designed for visible photons. This improvement comes from a simplified optics. The new camera transforms, by diffraction, each photo-event spot from an image intensifier or a scintillator into a cross-shaped pattern, which is projected onto a specific Gray code mask. The photo-event position is then extracted from the signal given by an array of avalanche photodiodes (or photomultiplier tubes, alternatively) downstream of the mask. After a detailed explanation of this camera concept that we have called "DIAMICON" (DIffraction Addressed Mask ICONographer), we briefly discuss about technical solutions to build such a camera.

Arrays of Position-Sensitive Virtual Frisch-Grid CdZnTe Detectors: Results From a $$4\\times 4$$ Array Prototype

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ocampo Giraldo, L. A.; Bolotnikov, A. E.; Camarda, G. S.

Position-sensitive virtual Frisch-grid (VFG) CdZnTe (CZT) detectors offer a unique capability for correcting the response nonuniformities caused by crystal defects. This allowed us to achieve high energy resolution, while using typical-grade commercial CZT crystals with relaxed requirements to their quality, thus reducing the overall cost of detectors. Another advantage of the VFG detectors is that they can be integrated into arrays and used in small compact hand-held instruments or large-area gamma cameras that will enhance detection capability for many practical applications, including nonproliferation, medical imaging, and gamma-ray astronomy. Here in this paper, we present the results from testing small arraymore » prototypes coupled with front-end application-specified integrated circuit. Each detector in the array is furnished with 5-mm-wide charge-sensing pads placed near the anode. The pads signals are converted into XY coordinates, which combined with the cathode signals (for Z coordinates) provide 3-D position information of all interaction points. The basic array consists of a number of detectors grouped into 2×2 subarrays, each having a common cathode made by connecting together the cathodes of the individual detectors. Lastly, these features can significantly improve the performance of detectors while using typical-grade low-cost CZT crystals to reduce the overall cost of the proposed instrument.« less

Arrays of Position-Sensitive Virtual Frisch-Grid CdZnTe Detectors: Results From a $$4\\times 4$$ Array Prototype

DOE PAGES

Ocampo Giraldo, L. A.; Bolotnikov, A. E.; Camarda, G. S.; ...

2017-08-22

Position-sensitive virtual Frisch-grid (VFG) CdZnTe (CZT) detectors offer a unique capability for correcting the response nonuniformities caused by crystal defects. This allowed us to achieve high energy resolution, while using typical-grade commercial CZT crystals with relaxed requirements to their quality, thus reducing the overall cost of detectors. Another advantage of the VFG detectors is that they can be integrated into arrays and used in small compact hand-held instruments or large-area gamma cameras that will enhance detection capability for many practical applications, including nonproliferation, medical imaging, and gamma-ray astronomy. Here in this paper, we present the results from testing small arraymore » prototypes coupled with front-end application-specified integrated circuit. Each detector in the array is furnished with 5-mm-wide charge-sensing pads placed near the anode. The pads signals are converted into XY coordinates, which combined with the cathode signals (for Z coordinates) provide 3-D position information of all interaction points. The basic array consists of a number of detectors grouped into 2×2 subarrays, each having a common cathode made by connecting together the cathodes of the individual detectors. Lastly, these features can significantly improve the performance of detectors while using typical-grade low-cost CZT crystals to reduce the overall cost of the proposed instrument.« less

Focal Plane Detectors for the Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Otte, A. N.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Horan, D.; Mukherjee, R.; Smith, A.; Tajima, H.; Wagner, R. G.; Williams, D. A.

2008-12-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Simulations show that a substantial improvement in angular resolution may be achieved if the pixel diameter is reduced to the order of 0.05 deg, i.e. two to three times smaller than the pixel diameter of current Cherenkov telescope cameras. At these dimensions, photon detectors with smaller physical dimensions can be attractive alternatives to the classical photomultiplier tube (PMT). Furthermore, the operation of an experiment with the size of AGIS requires photon detectors that are among other things more reliable, more durable, and possibly higher efficiency photon detectors. Alternative photon detectors we are considering for AGIS include both silicon photomultipliers (SiPMs) and multi-anode photomultipliers (MAPMTs). Here we present results from laboratory testing of MAPMTs and SiPMs along with results from the first incorporation of these devices into cameras on test bed Cherenkov telescopes.

A compact neutron scatter camera for field deployment

DOE PAGES

Goldsmith, John E. M.; Gerling, Mark D.; Brennan, James S.

2016-08-23

Here, we describe a very compact (0.9 m high, 0.4 m diameter, 40 kg) battery operable neutron scatter camera designed for field deployment. Unlike most other systems, the configuration of the sixteen liquid-scintillator detection cells are arranged to provide omnidirectional (4π) imaging with sensitivity comparable to a conventional two-plane system. Although designed primarily to operate as a neutron scatter camera for localizing energetic neutron sources, it also functions as a Compton camera for localizing gamma sources. In addition to describing the radionuclide source localization capabilities of this system, we demonstrate how it provides neutron spectra that can distinguish plutonium metalmore » from plutonium oxide sources, in addition to the easier task of distinguishing AmBe from fission sources.« less

Coded-aperture Compton camera for gamma-ray imaging

NASA Astrophysics Data System (ADS)

Farber, Aaron M.

This dissertation describes the development of a novel gamma-ray imaging system concept and presents results from Monte Carlo simulations of the new design. Current designs for large field-of-view gamma cameras suitable for homeland security applications implement either a coded aperture or a Compton scattering geometry to image a gamma-ray source. Both of these systems require large, expensive position-sensitive detectors in order to work effectively. By combining characteristics of both of these systems, a new design can be implemented that does not require such expensive detectors and that can be scaled down to a portable size. This new system has significant promise in homeland security, astronomy, botany and other fields, while future iterations may prove useful in medical imaging, other biological sciences and other areas, such as non-destructive testing. A proof-of-principle study of the new gamma-ray imaging system has been performed by Monte Carlo simulation. Various reconstruction methods have been explored and compared. General-Purpose Graphics-Processor-Unit (GPGPU) computation has also been incorporated. The resulting code is a primary design tool for exploring variables such as detector spacing, material selection and thickness and pixel geometry. The advancement of the system from a simple 1-dimensional simulation to a full 3-dimensional model is described. Methods of image reconstruction are discussed and results of simulations consisting of both a 4 x 4 and a 16 x 16 object space mesh have been presented. A discussion of the limitations and potential areas of further study is also presented.

The Advanced Gamma-ray Imaging System (AGIS): Camera Electronics Designs

NASA Astrophysics Data System (ADS)

Tajima, H.; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Holder, J.; Horan, D.; Krawczynski, H.; Ong, R.; Swordy, S.; Wagner, R.; Williams, D.

2008-04-01

AGIS, a next generation of atmospheric Cherenkov telescope arrays, aims to achieve a sensitivity level of a milliCrab for gamma-ray observations in the energy band of 40 GeV to 100 TeV. Such improvement requires cost reduction of individual components with high reliability in order to equip the order of 100 telescopes necessary to achieve the sensitivity goal. We are exploring several design concepts to reduce the cost of camera electronics while improving their performance. These design concepts include systems based on multi-channel waveform sampling ASIC optimized for AGIS, a system based on IIT (image intensifier tube) for large channel (order of 1 million channels) readout as well as a multiplexed FADC system based on the current VERITAS readout design. Here we present trade-off in the studies of these design concepts.

The Advanced Gamma-ray Imaging System (AGIS): Camera Electronics Designs

NASA Astrophysics Data System (ADS)

Tajima, Hiroyasu; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Holder, J.; Horan, D.; Krawczynski, H.; Ong, R.; Swordy, S.; Wagner, R.; Wakely, S.; Williams, D.; Camera Electronics Working Group; AGIS Collaboration

2008-03-01

AGIS, a next generation of atmospheric Cherenkov telescope arrays, aims to achieve a sensitivity level of a milliCrab for gamma-ray observations in in the energy band of 40 GeV to 100 TeV. Such improvement requires cost reduction of individual components with high reliability in order to equip the order of 100 telescopes necessary to achieve the sensitivity goal. We are exploring several design concepts to reduce the cost of camera electronics while improving their performance. These design concepts include systems based on multi-channel waveform sampling ASIC optimized for AGIS, a system based on IIT (image intensifier tube) for large channel (order of 1 million channels) readout as well as a multiplexed FADC system based on the current VERITAS readout design. Here we present trade-off studies of these design concepts.

Liver phantom for quality control and training in nuclear medicine

NASA Astrophysics Data System (ADS)

Lima Ferreira, Fernanda Carla; Souza, Divanizia do Nascimento

2011-10-01

In nuclear medicine, liver scintigraphy aims to verify organ function based on the radionuclide concentration in the liver and bile flow and is also used to detect tumors. Therefore it is necessary to perform quality control tests in the gamma camera before running the exam to prevent false results. Quality control tests of the gamma camera should thus be performed before running the exam to prevent false results. Such tests generally use radioactive material inside phantoms for evaluation of gamma camera parameters in quality control procedures. Phantoms can also be useful for training doctors and technicians in nuclear medicine procedures. The phantom proposed here has artifacts that simulate nodules; it may take on different quantities, locations and sizes and it may also be mounted without the introduction of nodules. Thus, its images may show hot or cold nodules or no nodules. The phantom consists of acrylic plates hollowed out in the centre, with the geometry of an adult liver. Images for analyses of simulated liver scintigraphy were obtained with the detector device at 5 cm from the anterior surface of the phantom. These simulations showed that this object is suitable for quality control in nuclear medicine because it was possible to visualize artifacts larger than 7.9 mm using a 256×256 matrix and 1000 kcpm. The phantom constructed in this work will also be useful for training practitioners and technicians in order to prevent patients from repeat testing caused by error during examinations.

Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system

DOEpatents

Kieper, Douglas Arthur [Seattle, WA; Majewski, Stanislaw [Morgantown, WV; Welch, Benjamin L [Hampton, VA

2012-07-03

An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system

DOEpatents

Kieper, Douglas Arthur [Newport News, VA; Majewski, Stanislaw [Yorktown, VA; Welch, Benjamin L [Hampton, VA

2008-10-28

An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

MeV gamma-ray observation with a well-defined point spread function based on electron tracking

NASA Astrophysics Data System (ADS)

Takada, A.; Tanimori, T.; Kubo, H.; Mizumoto, T.; Mizumura, Y.; Komura, S.; Kishimoto, T.; Takemura, T.; Yoshikawa, K.; Nakamasu, Y.; Matsuoka, Y.; Oda, M.; Miyamoto, S.; Sonoda, S.; Tomono, D.; Miuchi, K.; Kurosawa, S.; Sawano, T.

2016-07-01

The field of MeV gamma-ray astronomy has not opened up until recently owing to imaging difficulties. Compton telescopes and coded-aperture imaging cameras are used as conventional MeV gamma-ray telescopes; however their observations are obstructed by huge background, leading to uncertainty of the point spread function (PSF). Conventional MeV gamma-ray telescopes imaging utilize optimizing algorithms such as the ML-EM method, making it difficult to define the correct PSF, which is the uncertainty of a gamma-ray image on the celestial sphere. Recently, we have defined and evaluated the PSF of an electron-tracking Compton camera (ETCC) and a conventional Compton telescope, and thereby obtained an important result: The PSF strongly depends on the precision of the recoil direction of electron (scatter plane deviation, SPD) and is not equal to the angular resolution measure (ARM). Now, we are constructing a 30 cm-cubic ETCC for a second balloon experiment, Sub-MeV gamma ray Imaging Loaded-on-balloon Experiment: SMILE-II. The current ETCC has an effective area of 1 cm2 at 300 keV, a PSF of 10° at FWHM for 662 keV, and a large field of view of 3 sr. We will upgrade this ETCC to have an effective area of several cm2 and a PSF of 5° using a CF4-based gas. Using the upgraded ETCC, our observation plan for SMILE-II is to map of the electron-positron annihilation line and the 1.8 MeV line from 26Al. In this paper, we will report on the current performance of the ETCC and on our observation plan.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginsz, M.; Duchene, G.; Didierjean, F.

The state-of-the art gamma-ray spectrometers such as AGATA and GRETA are using position sensitive multi-segmented HPGe crystals. Pulse-shape analysis (PSA) allows to retrieve the localisation of the gamma interactions and to perform gamma-ray tracking within germanium. The precision of the localisation depends on the quality of the pulse-shape database used for comparison. The IPHC laboratory developed a new fast scanning table allowing to measure experimental pulse shapes in the whole volume of any crystal. The results of the scan of an AGATA 36-fold segmented tapered coaxial detector are shown here, 48580 experimental pulse shapes are extracted within 2 weeks ofmore » scanning. These data will contribute to AGATA PSA performances, but have also applications for gamma cameras or Compton-suppressed detectors. (authors)« less

Background simulations of the wide-field coded-mask camera for X-/Gamma-ray of the French-Chinese mission SVOM

NASA Astrophysics Data System (ADS)

Godet, Olivier; Barret, Didier; Paul, Jacques; Sizun, Patrick; Mandrou, Pierre; Cordier, Bertrand

SVOM (Space Variable Object Monitor) is a French-Chinese mission dedicated to the study of high-redshift GRBs, which is expected to be launched in 2012. The anti-Sun pointing strategy of SVOM along with a strong and integrated ground segment consisting of two wide-field robotic telescopes covering the near-IR and optical will optimise the ground-based GRB follow-ups by the largest telescopes and thus the measurements of spectroscopic redshifts. The central instrument of the science payload will be an innovative wide-field coded-mask camera for X- /Gamma-rays (4-250 keV) responsible for triggering and localising GRBs with an accuracy better than 10 arc-minutes. Such an instrument will be background-dominated so it is essential to estimate the background level expected once in orbit during the early phase of the instrument design in order to ensure good science performance. We present our Monte-Carlo simulator enabling us to compute the background spectrum taking into account the mass model of the camera and the main components of the space environment encountered in orbit by the satellite. From that computation, we show that the current design of the camera CXG will be more sensitive to high-redshift GRBs than the Swift-BAT thanks to its low-energy threshold of 4 keV.

The first demonstration of the concept of "narrow-FOV Si/CdTe semiconductor Compton camera"

NASA Astrophysics Data System (ADS)

Ichinohe, Yuto; Uchida, Yuusuke; Watanabe, Shin; Edahiro, Ikumi; Hayashi, Katsuhiro; Kawano, Takafumi; Ohno, Masanori; Ohta, Masayuki; Takeda, Shin`ichiro; Fukazawa, Yasushi; Katsuragawa, Miho; Nakazawa, Kazuhiro; Odaka, Hirokazu; Tajima, Hiroyasu; Takahashi, Hiromitsu; Takahashi, Tadayuki; Yuasa, Takayuki

2016-01-01

The Soft Gamma-ray Detector (SGD), to be deployed on board the ASTRO-H satellite, has been developed to provide the highest sensitivity observations of celestial sources in the energy band of 60-600 keV by employing a detector concept which uses a Compton camera whose field-of-view is restricted by a BGO shield to a few degree (narrow-FOV Compton camera). In this concept, the background from outside the FOV can be heavily suppressed by constraining the incident direction of the gamma ray reconstructed by the Compton camera to be consistent with the narrow FOV. We, for the first time, demonstrate the validity of the concept using background data taken during the thermal vacuum test and the low-temperature environment test of the flight model of SGD on ground. We show that the measured background level is suppressed to less than 10% by combining the event rejection using the anti-coincidence trigger of the active BGO shield and by using Compton event reconstruction techniques. More than 75% of the signals from the field-of-view are retained against the background rejection, which clearly demonstrates the improvement of signal-to-noise ratio. The estimated effective area of 22.8 cm2 meets the mission requirement even though not all of the operational parameters of the instrument have been fully optimized yet.

Ceres' Global Cryosphere

NASA Astrophysics Data System (ADS)

Sizemore, H. G.; Prettyman, T. H.; De Sanctis, M. C.; Schmidt, B. E.; Hughson, K.; Chilton, H.; Castillo, J. C.; Platz, T.; Schorghofer, N.; Bland, M. T.; Sori, M.; Buczkowski, D.; Byrne, S.; Landis, M. E.; Fu, R.; Ermakov, A.; Raymond, C. A.; Schwartz, S. J.

2017-12-01

Prior to the arrival of the Dawn spacecraft at Ceres, the dwarf planet was anticipated to have a deep global cryosphere protected by a thin silicate lag. Gravity science along with data collected by Dawn's Framing Camera (FC), Gamma Ray and Neutron Detector (GRaND), and Visible and Infrared Mapping Spectrometer (VIR-MS) during the primary mission at Ceres have confirmed the existence of a global, silicate-rich cryosphere, and suggest the existence of deeper ice, brine, or mud layers. As such, Ceres' surface morphology has characteristics in common with both Mars and the small icy bodies of the outer solar system. We will summarize the evidence for the existence and global extent of the Cerean cryosphere. We will also discuss the range of morphological features that have been linked to subsurface ice, and highlight outstanding science questions.

Performance verification of the FlashCam prototype camera for the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Werner, F.; Bauer, C.; Bernhard, S.; Capasso, M.; Diebold, S.; Eisenkolb, F.; Eschbach, S.; Florin, D.; Föhr, C.; Funk, S.; Gadola, A.; Garrecht, F.; Hermann, G.; Jung, I.; Kalekin, O.; Kalkuhl, C.; Kasperek, J.; Kihm, T.; Lahmann, R.; Marszalek, A.; Pfeifer, M.; Principe, G.; Pühlhofer, G.; Pürckhauer, S.; Rajda, P. J.; Reimer, O.; Santangelo, A.; Schanz, T.; Schwab, T.; Steiner, S.; Straumann, U.; Tenzer, C.; Vollhardt, A.; Wolf, D.; Zietara, K.; CTA Consortium

2017-12-01

The Cherenkov Telescope Array (CTA) is a future gamma-ray observatory that is planned to significantly improve upon the sensitivity and precision of the current generation of Cherenkov telescopes. The observatory will consist of several dozens of telescopes with different sizes and equipped with different types of cameras. Of these, the FlashCam camera system is the first to implement a fully digital signal processing chain which allows for a traceable, configurable trigger scheme and flexible signal reconstruction. As of autumn 2016, a prototype FlashCam camera for the medium-sized telescopes of CTA nears completion. First results of the ongoing system tests demonstrate that the signal chain and the readout system surpass CTA requirements. The stability of the system is shown using long-term temperature cycling.

Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera.

PubMed

Alhassen, Fares; Kudrolli, Haris; Singh, Bipin; Kim, Sangtaek; Seo, Youngho; Gould, Robert G; Nagarkar, Vivek V

2011-06-01

Preclinical SPECT offers a powerful means to understand the molecular pathways of drug interactions in animal models by discovering and testing new pharmaceuticals and therapies for potential clinical applications. A combination of high spatial resolution and sensitivity are required in order to map radiotracer uptake within small animals. Pinhole collimators have been investigated, as they offer high resolution by means of image magnification. One of the limitations of pinhole geometries is that increased magnification causes some rays to travel through the detection scintillator at steep angles, introducing parallax errors due to variable depth-of-interaction in scintillator material, especially towards the edges of the detector field of view. These parallax errors ultimately limit the resolution of pinhole preclinical SPECT systems, especially for higher energy isotopes that can easily penetrate through millimeters of scintillator material. A pixellated, focused-cut (FC) scintillator, with its pixels laser-cut so that they are collinear with incoming rays, can potentially compensate for these parallax errors and thus improve the system resolution. We performed the first experimental evaluation of a newly developed focused-cut scintillator. We scanned a Tc-99m source across the field of view of pinhole gamma camera with a continuous scintillator, a conventional "straight-cut" (SC) pixellated scintillator, and a focused-cut scintillator, each coupled to an electron-multiplying charge coupled device (EMCCD) detector by a fiber-optic taper, and compared the measured full-width half-maximum (FWHM) values. We show that the FWHMs of the focused-cut scintillator projections are comparable to the FWHMs of the thinner SC scintillator, indicating the effectiveness of the focused-cut scintillator in compensating parallax errors.

Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera

PubMed Central

Alhassen, Fares; Kudrolli, Haris; Singh, Bipin; Kim, Sangtaek; Seo, Youngho; Gould, Robert G.; Nagarkar, Vivek V.

2011-01-01

Preclinical SPECT offers a powerful means to understand the molecular pathways of drug interactions in animal models by discovering and testing new pharmaceuticals and therapies for potential clinical applications. A combination of high spatial resolution and sensitivity are required in order to map radiotracer uptake within small animals. Pinhole collimators have been investigated, as they offer high resolution by means of image magnification. One of the limitations of pinhole geometries is that increased magnification causes some rays to travel through the detection scintillator at steep angles, introducing parallax errors due to variable depth-of-interaction in scintillator material, especially towards the edges of the detector field of view. These parallax errors ultimately limit the resolution of pinhole preclinical SPECT systems, especially for higher energy isotopes that can easily penetrate through millimeters of scintillator material. A pixellated, focused-cut (FC) scintillator, with its pixels laser-cut so that they are collinear with incoming rays, can potentially compensate for these parallax errors and thus improve the system resolution. We performed the first experimental evaluation of a newly developed focused-cut scintillator. We scanned a Tc-99m source across the field of view of pinhole gamma camera with a continuous scintillator, a conventional “straight-cut” (SC) pixellated scintillator, and a focused-cut scintillator, each coupled to an electron-multiplying charge coupled device (EMCCD) detector by a fiber-optic taper, and compared the measured full-width half-maximum (FWHM) values. We show that the FWHMs of the focused-cut scintillator projections are comparable to the FWHMs of the thinner SC scintillator, indicating the effectiveness of the focused-cut scintillator in compensating parallax errors. PMID:21731108

Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera

NASA Astrophysics Data System (ADS)

Alhassen, Fares; Kudrolli, Haris; Singh, Bipin; Kim, Sangtaek; Seo, Youngho; Gould, Robert G.; Nagarkar, Vivek V.

2011-06-01

Preclinical SPECT offers a powerful means to understand the molecular pathways of drug interactions in animal models by discovering and testing new pharmaceuticals and therapies for potential clinical applications. A combination of high spatial resolution and sensitivity are required in order to map radiotracer uptake within small animals. Pinhole collimators have been investigated, as they offer high resolution by means of image magnification. One of the limitations of pinhole geometries is that increased magnification causes some rays to travel through the detection scintillator at steep angles, introducing parallax errors due to variable depth-of-interaction in scintillator material, especially towards the edges of the detector field of view. These parallax errors ultimately limit the resolution of pinhole preclinical SPECT systems, especially for higher energy isotopes that can easily penetrate through millimeters of scintillator material. A pixellated, focused-cut (FC) scintillator, with its pixels laser-cut so that they are collinear with incoming rays, can potentially compensate for these parallax errors and thus improve the system resolution. We performed the first experimental evaluation of a newly developed focused-cut scintillator. We scanned a Tc-99 m source across the field of view of pinhole gamma camera with a continuous scintillator, a conventional “straight-cut” (SC) pixellated scintillator, and a focused-cut scintillator, each coupled to an electron-multiplying charge coupled device (EMCCD) detector by a fiber-optic taper, and compared the measured full-width half-maximum (FWHM) values. We show that the FWHMs of the focused-cut scintillator projections are comparable to the FWHMs of the thinner SC scintillator, indicating the effectiveness of the focused-cut scintillator in compensating parallax errors.

Test of Compton camera components for prompt gamma imaging at the ELBE bremsstrahlung beam

NASA Astrophysics Data System (ADS)

Hueso-González, F.; Golnik, C.; Berthel, M.; Dreyer, A.; Enghardt, W.; Fiedler, F.; Heidel, K.; Kormoll, T.; Rohling, H.; Schöne, S.; Schwengner, R.; Wagner, A.; Pausch, G.

2014-05-01

In the context of ion beam therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several position sensitive gamma ray detectors, together with an imaging algorithm, is expected to reconstruct the prompt gamma ray emission density map, which is correlated with the dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), a Compton camera setup is being developed consisting of two scatter planes: two CdZnTe (CZT) cross strip detectors, and an absorber consisting of one Lu2SiO5 (LSO) block detector. The data acquisition is based on VME electronics and handled by software developed on the ROOT framework. The setup has been tested at the linear electron accelerator ELBE at HZDR, which is used in this experiment to produce bunched bremsstrahlung photons with up to 12.5 MeV energy and a repetition rate of 13 MHz. Their spectrum has similarities with the shape expected from prompt gamma rays in the clinical environment, and the flux is also bunched with the accelerator frequency. The charge sharing effect of the CZT detector is studied qualitatively for different energy ranges. The LSO detector pixel discrimination resolution is analyzed and it shows a trend to improve for high energy depositions. The time correlation between the pulsed prompt photons and the measured detector signals, to be used for background suppression, exhibits a time resolution of 3 ns FWHM for the CZT detector and of 2 ns for the LSO detector. A time walk correction and pixel-wise calibration is applied for the LSO detector, whose resolution improves up to 630 ps. In conclusion, the detector setup is suitable for time-resolved background suppression in pulsed clinical particle accelerators. Ongoing tasks are the quantitative comparison with simulations and the test of imaging algorithms. Experiments at proton accelerators have also been performed and are currently under analysis.

Two-modality γ detection of blood volume by camera imaging and nonimaging stethoscope for kinetic studies of cardiovascular control in nuclear medicine

NASA Astrophysics Data System (ADS)

Eclancher, Bernard; Chambron, Jacques; Dumitresco, Barbu; Karman, Miklos; Pszota, Agnes; Simon, Atilla; Didon-Poncelet, Anna; Demangeat, Jean

2002-04-01

The quantification of rapid hemodynamic reactions to wide and slow breathing movements has been performed, by two modalities (gamma) -left ventriculography of 99mTc-labeled blood volume, in anterior oblique incidence on standing and even exercising healthy volunteers and cardiac patients. A highly sensitive stethoscope delivered whole (gamma) -counts acquired at 30 msec intervals in a square field of view including the left ventricle, in a one dimensional low resolution imaging mode for beat to beat analysis. A planar 2D (gamma) -camera imaging of the same cardiac area was then performed without cardiac gating for alternate acquisitions during deep inspiration and deep expiration, completed by a 3D MRI assessment of the stethoscope detection field. Young healthy volunteers displayed wide variations of diastolic times and stroke volumes, as a result of enhanced baroreflex control, together with +/- 16% variations of the stethoscope's background blood volume counts. Any of the components of these responses were shifted, abolished or even inverted as a result of either obesity, hypertension, aging or cardiac pathologies. The assessment of breathing control of the cardiovascular system by the beat to beat (gamma) -ventriculography combined with nuclear 2D and 3D MRI imaging is a kinetic method allowing the detection of functional anomalies in still ambulatory patients.

Determination of in vivo behavior of mitomycin C-loaded o/w soybean oil microemulsion and mitomycin C solution via gamma camera imaging.

PubMed

Kotmakçı, Mustafa; Kantarcı, Gülten; Aşıkoğlu, Makbule; Ozkılıç, Hayal; Ertan, Gökhan

2013-09-01

In this study, a microemulsion system was evaluated for delivery of mitomycin C (MMC). To track the distribution of the formulated drug after intravenous administration, radiochemical labeling and gamma scintigraphy imaging were used. The aim was to evaluate a microemulsion system for intravenous delivery of MMC and to compare its in vivo behavior with that of the MMC solution. For microemulsion formulation, soybean oil was used as the oil phase. Lecithin and Tween 80 were surfactants and ethanol was the cosurfactant. To understand the whole body localization of MMC-loaded microemulsion, MMC was labeled with radioactive technetium and gamma scintigraphy was applied for visualization of drug distribution. Radioactivity in the bladder 30 minutes after injection of the MMC solution was observed, according to static gamma camera images. This shows that urinary excretion of the latter starts very soon. On the other hand, no radioactivity appeared in the urinary bladder during the 90 minutes following the administration of MMC-loaded microemulsion. The unabated radioactivity in the liver during the experiment shows that the localization of microemulsion formulation in the liver is stable. In the light of the foregoing, it is suggested that this microemulsion formulation may be an appropriate carrier system for anticancer agents by intravenous delivery in hepatic cancer chemotherapy.

The soft gamma-ray detector (SGD) onboard ASTRO-H

NASA Astrophysics Data System (ADS)

Watanabe, Shin; Tajima, Hiroyasu; Fukazawa, Yasushi; Blandford, Roger; Enoto, Teruaki; Goldwurm, Andrea; Hagino, Kouichi; Hayashi, Katsuhiro; Ichinohe, Yuto; Kataoka, Jun; Katsuta, Junichiro; Kitaguchi, Takao; Kokubun, Motohide; Laurent, Philippe; Lebrun, François; Limousin, Olivier; Madejski, Grzegorz M.; Makishima, Kazuo; Mizuno, Tsunefumi; Mori, Kunishiro; Nakamori, Takeshi; Nakano, Toshio; Nakazawa, Kazuhiro; Noda, Hirofumu; Odaka, Hirokazu; Ohno, Masanori; Ohta, Masayuki; Saito, Shinya; Sato, Goro; Sato, Rie; Takeda, Shin'ichiro; Takahashi, Hiromitsu; Takahashi, Tadayuki; Tanaka, Takaaki; Tanaka, Yasuyuki; Terada, Yukikatsu; Uchiyama, Hideki; Uchiyama, Yasunobu; Yamaoka, Kazutaka; Yatsu, Yoichi; Yonetoku, Daisuke; Yuasa, Takayuki

2016-07-01

The Soft Gamma-ray Detector (SGD) is one of science instruments onboard ASTRO-H (Hitomi) and features a wide energy band of 60{600 keV with low backgrounds. SGD is an instrument with a novel concept of "Narrow field-of-view" Compton camera where Compton kinematics is utilized to reject backgrounds which are inconsistent with the field-of-view defined by the active shield. After several years of developments, the flight hardware was fabricated and subjected to subsystem tests and satellite system tests. After a successful ASTRO-H (Hitomi) launch on February 17, 2016 and a critical phase operation of satellite and SGD in-orbit commissioning, the SGD operation was moved to the nominal observation mode on March 24, 2016. The Compton cameras and BGO-APD shields of SGD worked properly as designed. On March 25, 2016, the Crab nebula observation was performed, and, the observation data was successfully obtained.

Basic performance and stability of a CdTe solid-state detector panel.

PubMed

Tsuchiya, Katsutoshi; Takahashi, Isao; Kawaguchi, Tsuneaki; Yokoi, Kazuma; Morimoto, Yuuichi; Ishitsu, Takafumi; Suzuki, Atsurou; Ueno, Yuuichirou; Kobashi, Keiji

2010-05-01

We have developed a prototype gamma camera system (R1-M) using a cadmium telluride (CdTe) detector panel and evaluated the basic performance and the spectral stability. The CdTe panel consists of 5-mm-thick crystals. The field of view is 134 x 268 mm comprising 18,432 pixels with a pixel pitch of 1.4 mm. Replaceable small CdTe modules are mounted on to the circuit board by dedicated zero insertion force connectors. To make the readout circuit compact, the matrix read out is processed by dedicated ASICs. The panel is equipped with a cold-air cooling system. The temperature and humidity in the panel were kept at 20 degrees C and below 70% relative humidity. CdTe polarization was suppressed by the bias refresh technique to stabilize the detector. We also produced three dedicated square pixel-matched collimators: LEGP (20 mm-thick), LEHR (27 mm-thick), and LEUHR (35 mm-thick). We evaluated their basic performance (energy resolution, system resolution, and sensitivity) and the spectral stability in terms of short-term (several hours of continuous acquisition) and long-term (infrequent measurements over more than a year) activity. The intrinsic energy resolution (FWHM) acquired with Tc-99m (140.5 keV) was 6.6%. The spatial resolutions (FWHM at a distance of 100 mm) with LEGP, LEHR, and LEUHR collimators were 5.7, 4.9, and 4.2 mm, and the sensitivities were 71, 39, and 23 cps/MBq, respectively. The energy peak position and the intrinsic energy resolution after several hours of operation were nearly the same as the values a few minutes after the system was powered on; the variation of the peak position was <0.2%, and that of the resolution was about 0.3%. Infrequent measurements conducted over a year showed that the variations of the energy peak position and the intrinsic energy resolution of the system were at a similar level to those described above. The basic performance of the CdTe-gamma camera system was evaluated, and its stability was verified. It was shown that the camera could be operated daily for several months without calibration.

SU-C-9A-02: Structured Noise Index as An Automated Quality Control for Nuclear Medicine: A Two Year Experience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, J; Christianson, O; Samei, E

Purpose: Flood-field uniformity evaluation is an essential element in the assessment of nuclear medicine (NM) gamma cameras. It serves as the central element of the quality control (QC) program, acquired and analyzed on a daily basis prior to clinical imaging. Uniformity images are traditionally analyzed using pixel value-based metrics which often fail to capture subtle structure and patterns caused by changes in gamma camera performance requiring additional visual inspection which is subjective and time demanding. The goal of this project was to develop and implement a robust QC metrology for NM that is effective in identifying non-uniformity issues, reporting issuesmore » in a timely manner for efficient correction prior to clinical involvement, all incorporated into an automated effortless workflow, and to characterize the program over a two year period. Methods: A new quantitative uniformity analysis metric was developed based on 2D noise power spectrum metrology and confirmed based on expert observer visual analysis. The metric, termed Structured Noise Index (SNI) was then integrated into an automated program to analyze, archive, and report on daily NM QC uniformity images. The effectiveness of the program was evaluated over a period of 2 years. Results: The SNI metric successfully identified visually apparent non-uniformities overlooked by the pixel valuebased analysis methods. Implementation of the program has resulted in nonuniformity identification in about 12% of daily flood images. In addition, due to the vigilance of staff response, the percentage of days exceeding trigger value shows a decline over time. Conclusion: The SNI provides a robust quantification of the NM performance of gamma camera uniformity. It operates seamlessly across a fleet of multiple camera models. The automated process provides effective workflow within the NM spectra between physicist, technologist, and clinical engineer. The reliability of this process has made it the preferred platform for NM uniformity analysis.« less

Miniaturized fundus camera

NASA Astrophysics Data System (ADS)

Gliss, Christine; Parel, Jean-Marie A.; Flynn, John T.; Pratisto, Hans S.; Niederer, Peter F.

2003-07-01

We present a miniaturized version of a fundus camera. The camera is designed for the use in screening for retinopathy of prematurity (ROP). There, but also in other applications a small, light weight, digital camera system can be extremely useful. We present a small wide angle digital camera system. The handpiece is significantly smaller and lighter then in all other systems. The electronics is truly portable fitting in a standard boardcase. The camera is designed to be offered at a compatible price. Data from tests on young rabbits' eyes is presented. The development of the camera system is part of a telemedicine project screening for ROP. Telemedical applications are a perfect application for this camera system using both advantages: the portability as well as the digital image.

Testing and Performance Validation of a Sensitive Gamma Ray Camera Designed for Radiation Detection and Decommissioning Measurements in Nuclear Facilities-13044

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mason, John A.; Looman, Marc R.; Poundall, Adam J.

2013-07-01

This paper describes the measurements, testing and performance validation of a sensitive gamma ray camera designed for radiation detection and quantification in the environment and decommissioning and hold-up measurements in nuclear facilities. The instrument, which is known as RadSearch, combines a sensitive and highly collimated LaBr{sub 3} scintillation detector with an optical (video) camera with controllable zoom and focus and a laser range finder in one detector head. The LaBr{sub 3} detector has a typical energy resolution of between 2.5% and 3% at the 662 keV energy of Cs-137 compared to that of NaI detectors with a resolution of typicallymore » 7% to 8% at the same energy. At this energy the tungsten shielding of the detector provides a shielding ratio of greater than 900:1 in the forward direction and 100:1 on the sides and from the rear. The detector head is mounted on a pan/tile mechanism with a range of motion of ±180 degrees (pan) and ±90 degrees (tilt) equivalent to 4 π steradians. The detector head with pan/tilt is normally mounted on a tripod or wheeled cart. It can also be mounted on vehicles or a mobile robot for access to high dose-rate areas and areas with high levels of contamination. Ethernet connects RadSearch to a ruggedized notebook computer from which it is operated and controlled. Power can be supplied either as 24-volts DC from a battery or as 50 volts DC supplied by a small mains (110 or 230 VAC) power supply unit that is co-located with the controlling notebook computer. In this latter case both power and Ethernet are supplied through a single cable that can be up to 80 metres in length. If a local battery supplies power, the unit can be controlled through wireless Ethernet. Both manual operation and automatic scanning of surfaces and objects is available through the software interface on the notebook computer. For each scan element making up a part of an overall scanned area, the unit measures a gamma ray spectrum. Multiple radionuclides may be selected by the operator and will be identified if present. In scanning operation the unit scans a designated region and superimposes over a video image the distribution of measured radioactivity. For the total scanned area or object RadSearch determines the total activity of operator selected radionuclides present and the gamma dose-rate measured at the detector head. Results of hold-up measurements made in a nuclear facility are presented, as are test measurements of point sources distributed arbitrarily on surfaces. These latter results are compared with the results of benchmarked MCNP Monte Carlo calculations. The use of the device for hold-up and decommissioning measurements is validated. (authors)« less

Airborne multispectral identification of individual cotton plants using consumer-grade cameras

USDA-ARS?s Scientific Manuscript database

Although multispectral remote sensing using consumer-grade cameras has successfully identified fields of small cotton plants, improvements to detection sensitivity are needed to identify individual or small clusters of plants. The imaging sensor of consumer-grade cameras are based on a Bayer patter...

Identifying High-redshift Gamma-Ray Bursts with RATIR

NASA Astrophysics Data System (ADS)

Littlejohns, O. M.; Butler, N. R.; Cucchiara, A.; Watson, A. M.; Kutyrev, A. S.; Lee, W. H.; Richer, M. G.; Klein, C. R.; Fox, O. D.; Prochaska, J. X.; Bloom, J. S.; Troja, E.; Ramirez-Ruiz, E.; de Diego, J. A.; Georgiev, L.; González, J.; Román-Zúñiga, C. G.; Gehrels, N.; Moseley, H.

2014-07-01

We present a template-fitting algorithm for determining photometric redshifts, z phot, of candidate high-redshift gamma-ray bursts (GRBs). Using afterglow photometry, obtained by the Reionization and Transients InfraRed (RATIR) camera, this algorithm accounts for the intrinsic GRB afterglow spectral energy distribution, host dust extinction, and the effect of neutral hydrogen (local and cosmological) along the line of sight. We present the results obtained by this algorithm and the RATIR photometry of GRB 130606A, finding a range of best-fit solutions, 5.6 < z phot < 6.0, for models of several host dust extinction laws (none, the Milky Way, Large Magellanic Clouds, and Small Magellanic Clouds), consistent with spectroscopic measurements of the redshift of this GRB. Using simulated RATIR photometry, we find that our algorithm provides precise measures of z phot in the ranges of 4 < z phot <~ 8 and 9 < z phot < 10 and can robustly determine when z phot > 4. Further testing highlights the required caution in cases of highly dust-extincted host galaxies. These tests also show that our algorithm does not erroneously find z phot < 4 when z sim > 4, thereby minimizing false negatives and allowing us to rapidly identify all potential high-redshift events.

Thermal Neutron Tomography for Cultural Heritage at INR

NASA Astrophysics Data System (ADS)

Dinca, Marin; Mandescu, Dragos

The neutron and gamma imaging facility placed at the tangential channel of the TRIGA-ACPR from INR was used for tomography investigations on a test object with good results and shortly followed its involvement for tomography investigations on prehistoric statues of clay from the Arges County Museum. This activity was performed in connection with a research contract with IAEA with title ;The neutron and gamma imaging method combined with neutron-based analytical methods for cultural heritage research;, in the frame of a current CRP, that helps curators to reveal the internal structure and composition of the objects. The detector system has been developed based on two interchangeable scintillators, one for thermal neutrons and the other one for gamma radiations, a mirror of float glass coated with aluminum and two interchangeable CCD cameras. Experiments of tomography imaging for two prehistoric statues of clay with CCD STARLIGHT XPRESS SXV-H9 camera with XD-4 type image intensifier are presented in this paper. The tomography reconstructions with Octopus software have shown the potential of good results even for 100 projections/1800. This was a good opportunity for the dissemination of the investigation methods based on neutrons for cultural heritage and beyond this area.

Effect of different thickness of material filter on Tc-99m spectra and performance parameters of gamma camera

NASA Astrophysics Data System (ADS)

Nazifah, A.; Norhanna, S.; Shah, S. I.; Zakaria, A.

2014-11-01

This study aimed to investigate the effects of material filter technique on Tc-99m spectra and performance parameters of Philip ADAC forte dual head gamma camera. Thickness of material filter was selected on the basis of percentage attenuation of various gamma ray energies by different thicknesses of zinc material. A cylindrical source tank of NEMA single photon emission computed tomography (SPECT) Triple Line Source Phantom filled with water and Tc-99m radionuclide injected was used for spectra, uniformity and sensitivity measurements. Vinyl plastic tube was used as a line source for spatial resolution. Images for uniformity were reconstructed by filtered back projection method. Butterworth filter of order 5 and cut off frequency 0.35 cycles/cm was selected. Chang's attenuation correction method was applied by selecting 0.13/cm linear attenuation coefficient. Count rate was decreased with material filter from the compton region of Tc-99m energy spectrum, also from the photopeak region. Spatial resolution was improved. However, uniformity of tomographic image was equivocal, and system volume sensitivity was reduced by material filter. Material filter improved system's spatial resolution. Therefore, the technique may be used for phantom studies to improve the image quality.

Focal Plane Detectors for the Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Wagner, Robert G.; AGIS Photodetector Group; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Horan, D.; Mukherjee, R.; Tajima, H.; Williams, D.

2008-03-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. It is being designed to achieve a significant improvement in sensitivity compared to current Imaging Air Cherenkov Telescope (IACT) Arrays. One of the main requirements in order that AGIS fulfill this goal will be to achieve higher angular resolution than current IACTs. Simulations show that a substantial improvement in angular resolution may be achieved if the pixel size is reduced to less than 0.05 deg, i.e. two to three times smaller than the pixel size of current IACT cameras. With finer pixelation and the plan to deploy on the order of 100 telescopes in the AGIS array, the channel count will exceed 1,000,000 imaging pixels. High uniformity and long mean time-to-failure will be important aspects of a successful photodetector technology choice. Here we present alternatives being considered for AGIS, including both silicon photomultipliers (SiPMs) and multi-anode photomultipliers (MAPMTs). Results from laboratory testing of MAPMTs and SiPMs are presented along with results from the first incorporation of these devices in cameras on test bed Cherenkov telescopes.

Development of a composite large-size SiPM (assembled matrix) based modular detector cluster for MAGIC

NASA Astrophysics Data System (ADS)

Hahn, A.; Mazin, D.; Bangale, P.; Dettlaff, A.; Fink, D.; Grundner, F.; Haberer, W.; Maier, R.; Mirzoyan, R.; Podkladkin, S.; Teshima, M.; Wetteskind, H.

2017-02-01

The MAGIC collaboration operates two 17 m diameter Imaging Atmospheric Cherenkov Telescopes (IACTs) on the Canary Island of La Palma. Each of the two telescopes is currently equipped with a photomultiplier tube (PMT) based imaging camera. Due to the advances in the development of Silicon Photomultipliers (SiPMs), they are becoming a widely used alternative to PMTs in many research fields including gamma-ray astronomy. Within the Otto-Hahn group at the Max Planck Institute for Physics, Munich, we are developing a SiPM based detector module for a possible upgrade of the MAGIC cameras and also for future experiments as, e.g., the Large Size Telescopes (LST) of the Cherenkov Telescope Array (CTA). Because of the small size of individual SiPM sensors (6 mm×6 mm) with respect to the 1-inch diameter PMTs currently used in MAGIC, we use a custom-made matrix of SiPMs to cover the same detection area. We developed an electronic circuit to actively sum up and amplify the SiPM signals. Existing non-imaging hexagonal light concentrators (Winston cones) used in MAGIC have been modified for the angular acceptance of the SiPMs by using C++ based ray tracing simulations. The first prototype based detector module includes seven channels and was installed into the MAGIC camera in May 2015. We present the results of the first prototype and its performance as well as the status of the project and discuss its challenges.

Atmospheric Seeing and Transparency Robotic Observatory

NASA Astrophysics Data System (ADS)

Cline, J. D.; Castelaz, M. W.

2002-12-01

A robotic 12.7 cm telescope and camera (together called OVIEW) have been designed to do photometry of 50 of the brightest stars in the local sky 24 hours a day. Each star is imaged through a broadband 500 nm filter. Software automatically analyzes the brightness of the star and the stellar seeing disk. The results are published in real-time on a web page. Comparison of stellar brightness with known apparent magnitude is a measure of transparency with instrument resolution of one arcsecond. We will describe the observatory, software, and website. We will also describe other telescopes on the Optical Ridge at the Pisgah Astronomical Research Institute (PARI). On the same pier as OVIEW is a second robotic 12.7 cm telescope and camera that image the sun and moon. The solar and lunar images are published live on the Internet. Also on the Optical Ridge is a robotic 20 cm telescope. This telescope is operated by UNC-Chapel Hill and has been operating on the Optical Ridge for more than 2 years surveying the plane of the Milky Way for binary low mass stars. UNC-Chapel Hill also operates a 25 cm telescope with an IR camera for photometry of gamma ray burst optical afterglows. An additional 25 cm telescope with a new 3.2 megapixel CCD is used for undergraduate research and W UMa binary star photometry. We acknowledge the AAS Small Grant Program for partial support of the solar/lunar telescope.

Performance and Calibration of H2RG Detectors and SIDECAR ASICs for the RATIR Camera

NASA Technical Reports Server (NTRS)

Fox, Ori D.; Kutyrev, Alexander S.; Rapchun, David A.; Klein, Christopher R.; Butler, Nathaniel R.; Bloom, Josh; de Diego, Jos A.; Simn Farah, Alejandro D.; Gehrels, Neil A.; Georgiev, Leonid;

Nuclear medicine imaging system

DOEpatents

Bennett, G.W.; Brill, A.B.; Bizais, Y.J.C.; Rowe, R.W.; Zubal, I.G.

1983-03-11

It is an object of this invention to provide a nuclear imaging system having the versatility to do positron annihilation studies, rotating single or opposed camera gamma emission studies, and orthogonal gamma emission studies. It is a further object of this invention to provide an imaging system having the capability for orthogonal dual multipinhole tomography. It is another object of this invention to provide a nuclear imaging system in which all available energy data, as well as patient physiological data, are acquired simultaneously in list mode.

Optical photometric monitoring of gamma -ray loud blazars. II. Observations from November 1995 to June 1996

NASA Astrophysics Data System (ADS)

Raiteri, C. M.; Ghisellini, G.; Villata, M.; de Francesco, G.; Lanteri, L.; Chiaberge, M.; Peila, A.; Antico, G.

1998-02-01

New data from the optical monitoring of gamma -ray loud blazars at the Torino Astronomical Observatory are presented. Observations have been taken in the Johnson's B, V, and Cousins' R bands with the 1.05m REOSC telescope equipped with a 1242x1152 pixel CCD camera. Many of the 22 monitored sources presented here show noticeable magnitude variations. Periods corresponding to pointings of the Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory (CGRO) satellite are indicated on the light curves. The comparison of our data with those taken by CGRO in the gamma -ray band will contribute to better understand the mechanism of the gamma -ray emission. We finally show intranight light curves of 3C 66A and OJ 287, where microvariability was detected. Tables 2--21 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html

The Use of Gamma-Ray Imaging to Improve Portal Monitor Performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziock, Klaus-Peter; Collins, Jeff; Fabris, Lorenzo

2008-01-01

We have constructed a prototype, rapid-deployment portal monitor that uses visible-light and gamma-ray imaging to allow simultaneous monitoring of multiple lanes of traffic from the side of a roadway. Our Roadside Tracker uses automated target acquisition and tracking (TAT) software to identify and track vehicles in visible light images. The field of view of the visible camera overlaps with and is calibrated to that of a one-dimensional gamma-ray imager. The TAT code passes information on when vehicles enter and exit the system field of view and when they cross gamma-ray pixel boundaries. Based on this in-formation, the gamma-ray imager "harvests"more » the gamma-ray data specific to each vehicle, integrating its radiation signature for the entire time that it is in the field of view. In this fashion we are able to generate vehicle-specific radiation signatures and avoid source confusion problems that plague nonimaging approaches to the same problem.« less

Recent Improvement of Measurement Instrumentation to Supervise Nuclear Operations and to Contribute Input Data to 3D Simulation Code - 13289

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahe, Charly; Chabal, Caroline

2013-07-01

The CEA has developed many compact characterization tools to follow sensitive operations in a nuclear environment. Usually, these devices are made to carry out radiological inventories, to prepare nuclear interventions or to supervise some special operations. These in situ measurement techniques mainly take place at different stages of clean-up operations and decommissioning projects, but they are also in use to supervise sensitive operations when the nuclear plant is still operating. In addition to this, such tools are often associated with robots to access very highly radioactive areas, and thus can be used in accident situations. Last but not least, themore » radiological data collected can be entered in 3D calculation codes used to simulate the doses absorbed by workers in real time during operations in a nuclear environment. Faced with these ever-greater needs, nuclear measurement instrumentation always has to involve on-going improvement processes. Firstly, this paper will describe the latest developments and results obtained in both gamma and alpha imaging techniques. The gamma camera has been used by the CEA since the 1990's and several changes have made this device more sensitive, more compact and more competitive for nuclear plant operations. It is used to quickly identify hot spots, locating irradiating sources from 50 keV to 1500 keV. Several examples from a wide field of applications will be presented, together with the very latest developments. The alpha camera is a new camera used to see invisible alpha contamination on several kinds of surfaces. The latest results obtained allow real time supervision of a glove box cleaning operation (for {sup 241}Am contamination). The detection principle as well as the main trials and results obtained will be presented. Secondly, this paper will focus on in situ gamma spectrometry methods developed by the CEA with compact gamma spectrometry probes (CdZnTe, LaBr{sub 3}, NaI, etc.). The radiological data collected is used to quantify the activity of hot spots and can also then be entered in 3D models of nuclear plants to simulate intervention scenarios. Recent developments and results will be presented regarding this. Finally, thanks to a large amount of feedback, the interest of using complementary measurements will be discussed. In fact, the recent use of 3D simulation codes requires very accurate knowledge of nuclear plant radiological data. The use of coupled devices such as imaging devices, (gamma and alpha cameras), gamma spectrometry, dose rate mapping, collimated / un-collimated measurements and many other physical values gives an approach to the radiological knowledge of a process or plant with the lowest possible uncertainty. In line with this, the paper will conclude with the future developments and trials that could be assessed in that field of application. (authors)« less

Heart Imaging System

NASA Technical Reports Server (NTRS)

1993-01-01

Johnson Space Flight Center's device to test astronauts' heart function in microgravity has led to the MultiWire Gamma Camera, which images heart conditions six times faster than conventional devices. Dr. Jeffrey Lacy, who developed the technology as a NASA researcher, later formed Proportional Technologies, Inc. to develop a commercially viable process that would enable use of Tantalum-178 (Ta-178), a radio-pharmaceutical. His company supplies the generator for the radioactive Ta-178 to Xenos Medical Systems, which markets the camera. Ta-178 can only be optimally imaged with the camera. Because the body is subjected to it for only nine minutes, the radiation dose is significantly reduced and the technique can be used more frequently. Ta-178 also enables the camera to be used on pediatric patients who are rarely studied with conventional isotopes because of the high radiation dosage.

Development and Operation of a High Resolution Positron Emission Tomography System to Perform Metabolic Studies on Small Animals.

NASA Astrophysics Data System (ADS)

Hogan, Matthew John

A positron emission tomography system designed to perform high resolution imaging of small volumes has been characterized. Two large area planar detectors, used to detect the annihilation gamma rays, formed a large aperture stationary positron camera. The detectors were multiwire proportional chambers coupled to high density lead stack converters. Detector efficiency was 8%. The coincidence resolving time was 500 nsec. The maximum system sensitivity was 60 cps/(mu)Ci for a solid angle of acceptance of 0.74(pi) St. The maximum useful coincidence count rate was 1500 cps and was limited by electronic dead time. Image reconstruction was done by performing a 3-dimensional deconvolution using Fourier transform methods. Noise propagation during reconstruction was minimized by choosing a 'minimum norm' reconstructed image. In the stationary detector system (with a limited angle of acceptance for coincident events) statistical uncertainty in the data limited reconstruction in the direction normal to the detector surfaces. Data from a rotated phantom showed that detector rotation will correct this problem. Resolution was 4 mm in planes parallel to the detectors and (TURN)15 mm in the normal direction. Compton scattering of gamma rays within a source distribution was investigated using both simulated and measured data. Attenuation due to scatter was as high as 60%. For small volume imaging the Compton background was identified and an approximate correction was performed. A semiquantitative blood flow measurement to bone in the leg of a cat using the ('18)F('-) ion was performed. The results were comparable to investigations using more conventional techniques. Qualitative scans using ('18)F labelled deoxy -D-glucose to assess brain glucose metabolism in a rhesus monkey were also performed.

Accuracy, resolution, and cost comparisons between small format and mapping cameras for environmental mapping

NASA Technical Reports Server (NTRS)

Clegg, R. H.; Scherz, J. P.

1975-01-01

Successful aerial photography depends on aerial cameras providing acceptable photographs within cost restrictions of the job. For topographic mapping where ultimate accuracy is required only large format mapping cameras will suffice. For mapping environmental patterns of vegetation, soils, or water pollution, 9-inch cameras often exceed accuracy and cost requirements, and small formats may be better. In choosing the best camera for environmental mapping, relative capabilities and costs must be understood. This study compares resolution, photo interpretation potential, metric accuracy, and cost of 9-inch, 70mm, and 35mm cameras for obtaining simultaneous color and color infrared photography for environmental mapping purposes.

New Airborne Sensors and Platforms for Solving Specific Tasks in Remote Sensing

NASA Astrophysics Data System (ADS)

Kemper, G.

2012-07-01

A huge number of small and medium sized sensors entered the market. Today's mid format sensors reach 80 MPix and allow to run projects of medium size, comparable with the first big format digital cameras about 6 years ago. New high quality lenses and new developments in the integration prepared the market for photogrammetric work. Companies as Phase One or Hasselblad and producers or integrators as Trimble, Optec, and others utilized these cameras for professional image production. In combination with small camera stabilizers they can be used also in small aircraft and make the equipment small and easy transportable e.g. for rapid assessment purposes. The combination of different camera sensors enables multi or hyper-spectral installations e.g. useful for agricultural or environmental projects. Arrays of oblique viewing cameras are in the market as well, in many cases these are small and medium format sensors combined as rotating or shifting devices or just as a fixed setup. Beside the proper camera installation and integration, also the software that controls the hardware and guides the pilot has to solve much more tasks than a normal FMS did in the past. Small and relatively cheap Laser Scanners (e.g. Riegl) are in the market and a proper combination with MS Cameras and an integrated planning and navigation is a challenge that has been solved by different softwares. Turnkey solutions are available e.g. for monitoring power line corridors where taking images is just a part of the job. Integration of thermal camera systems with laser scanner and video capturing must be combined with specific information of the objects stored in a database and linked when approaching the navigation point.

Experimental Comparison of Knife-Edge and Multi-Parallel Slit Collimators for Prompt Gamma Imaging of Proton Pencil Beams.

PubMed

Smeets, Julien; Roellinghoff, Frauke; Janssens, Guillaume; Perali, Irene; Celani, Andrea; Fiorini, Carlo; Freud, Nicolas; Testa, Etienne; Prieels, Damien

2016-01-01

More and more camera concepts are being investigated to try and seize the opportunity of instantaneous range verification of proton therapy treatments offered by prompt gammas emitted along the proton tracks. Focusing on one-dimensional imaging with a passive collimator, the present study experimentally compared in combination with the first, clinically compatible, dedicated camera device the performances of instances of the two main options: a knife-edge slit (KES) and a multi-parallel slit (MPS) design. These two options were experimentally assessed in this specific context as they were previously demonstrated through analytical and numerical studies to allow similar performances in terms of Bragg peak retrieval precision and spatial resolution in a general context. Both collimators were prototyped according to the conclusions of Monte Carlo optimization studies under constraints of equal weight (40 mm tungsten alloy equivalent thickness) and of the specificities of the camera device under consideration (in particular 4 mm segmentation along beam axis and no time-of-flight discrimination, both of which less favorable to the MPS performance than to the KES one). Acquisitions of proton pencil beams of 100, 160, and 230 MeV in a PMMA target revealed that, in order to reach a given level of statistical precision on Bragg peak depth retrieval, the KES collimator requires only half the dose the present MPS collimator needs, making the KES collimator a preferred option for a compact camera device aimed at imaging only the Bragg peak position. On the other hand, the present MPS collimator proves more effective at retrieving the entrance of the beam in the target in the context of an extended camera device aimed at imaging the whole proton track within the patient.

Field-deployable gamma-radiation detectors for DHS use

NASA Astrophysics Data System (ADS)

Mukhopadhyay, Sanjoy

2007-09-01

Recently, the Department of Homeland Security (DHS) has integrated all nuclear detection research, development, testing, evaluation, acquisition, and operational support into a single office: the Domestic Nuclear Detection Office (DNDO). The DNDO has specific requirements set for all commercial off-the-shelf and government off-the-shelf radiation detection equipment and data acquisition systems. This article would investigate several recent developments in field deployable gamma radiation detectors that are attempting to meet the DNDO specifications. Commercially available, transportable, handheld radio isotope identification devices (RIID) are inadequate for DHS' requirements in terms of sensitivity, resolution, response time, and reach-back capability. The leading commercial vendor manufacturing handheld gamma spectrometer in the United States is Thermo Electron Corporation. Thermo Electron's identiFINDER TM, which primarily uses sodium iodide crystals (3.18 x 2.54cm cylinders) as gamma detectors, has a Full-Width-at-Half-Maximum energy resolution of 7 percent at 662 keV. Thermo Electron has just recently come up with a reach-back capability patented as RadReachBack TM that enables emergency personnel to obtain real-time technical analysis of radiation samples they find in the field1. The current project has the goal to build a prototype handheld gamma spectrometer, equipped with a digital camera and an embedded cell phone to be used as an RIID with higher sensitivity, better resolution, and faster response time (able to detect the presence of gamma-emitting radio isotopes within 5 seconds of approach), which will make it useful as a field deployable tool. The handheld equipment continuously monitors the ambient gamma radiation, and, if it comes across any radiation anomalies with higher than normal gamma gross counts, it sets an alarm condition. When a substantial alarm level is reached, the system automatically triggers the saving of relevant spectral data and software-triggers the digital camera to take a snapshot. The spectral data including in situ analysis and the imagery data will be packaged in a suitable format and sent to a command post using an imbedded cell phone.

High-Speed Data Acquisition and Digital Signal Processing System for PET Imaging Techniques Applied to Mammography

NASA Astrophysics Data System (ADS)

Martinez, J. D.; Benlloch, J. M.; Cerda, J.; Lerche, Ch. W.; Pavon, N.; Sebastia, A.

2004-06-01

This paper is framed into the Positron Emission Mammography (PEM) project, whose aim is to develop an innovative gamma ray sensor for early breast cancer diagnosis. Currently, breast cancer is detected using low-energy X-ray screening. However, functional imaging techniques such as PET/FDG could be employed to detect breast cancer and track disease changes with greater sensitivity. Furthermore, a small and less expensive PET camera can be utilized minimizing main problems of whole body PET. To accomplish these objectives, we are developing a new gamma ray sensor based on a newly released photodetector. However, a dedicated PEM detector requires an adequate data acquisition (DAQ) and processing system. The characterization of gamma events needs a free-running analog-to-digital converter (ADC) with sampling rates of more than 50 Ms/s and must achieve event count rates up to 10 MHz. Moreover, comprehensive data processing must be carried out to obtain event parameters necessary for performing the image reconstruction. A new generation digital signal processor (DSP) has been used to comply with these requirements. This device enables us to manage the DAQ system at up to 80 Ms/s and to execute intensive calculi over the detector signals. This paper describes our designed DAQ and processing architecture whose main features are: very high-speed data conversion, multichannel synchronized acquisition with zero dead time, a digital triggering scheme, and high throughput of data with an extensive optimization of the signal processing algorithms.

Enclosure for small animals during awake animal imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goddard, Jr., James S

An enclosure or burrow restrains an awake animal during an imaging procedure. A tubular body, made from a radiolucent material that does not attenuate x-rays or gamma rays, accepts an awake animal. A proximal end of the body includes an attachment surface that corresponds to an attachment surface of an optically transparent and optically uniform window. An anti-reflective coating may be applied to an inner surface, an outer surface, or both surfaces of the window. Since the window is a separate element of the enclosure and it is not integrally formed as part of the body, it can be mademore » with optically uniform thickness properties for improved motion tracking of markers on the animal with a camera during the imaging procedure. The motion tracking information is then used to compensate for animal movement in the image.« less

South Polar Polygons

NASA Technical Reports Server (NTRS)

2004-01-01

4 March 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a spectacular suite of large and small polygons in the south polar region. On Earth, polygons such as these would be indicators of the presence of ground ice. Whether this is true for Mars remains to be determined, but it is interesting to note that these polygons do occur in a region identified by the Mars Odyssey Gamma Ray Spectrometer (GRS) team as a place with possible ground ice. The polygons are in an old impact crater located near 62.9oS, 281.4oW. This 1.5 meter (5 ft.) per pixel view covers an area 3 km (1.9 mi) wide and is illuminated by sunlight from the upper left. To see the smaller set of polygons, the reader must view the full-resolution image (click on picture, above).

MOXE: An X-ray all-sky monitor for Soviet Spectrum-X-Gamma Mission

NASA Technical Reports Server (NTRS)

Priedhorsky, W.; Fenimore, E. E.; Moss, C. E.; Kelley, R. L.; Holt, S. S.

1989-01-01

A Monitoring Monitoring X-Ray Equipment (MOXE) is being developed for the Soviet Spectrum-X-Gamma Mission. MOXE is an X-ray all-sky monitor based on array of pinhole cameras, to be provided via a collaboration between Goddard Space Flight Center and Los Alamos National Laboratory. The objectives are to alert other observers on Spectrum-X-Gamma and other platforms of interesting transient activity, and to synoptically monitor the X-ray sky and study long-term changes in X-ray binaries. MOXE will be sensitive to sources as faint as 2 milliCrab (5 sigma) in 1 day, and cover the 2 to 20 KeV band.

Elemental abundances of the B and A stars Gamma Geminorum, 7 Sextantis, HR 4817, and HR 5780

NASA Technical Reports Server (NTRS)

Adelman, Saul J.; Philip, A. G. D.

1992-01-01

Fine analyses of the B and A stars, Gamma Geminorum, 7 Sextantis, HR 4817, and HR 5780 are performed. Although the data cover rather limited spectral regions, still useful results were obtained. The data were mostly obtained at the KPNO coude feed telescope with CCD TI No. 3, camera 5, and grating A. The He/H ratio of HR 4817 confirms the similarity of many abundance values with those of the peculiar Mn star 53 Tauri. For the most part Gamma Gem, 7 Sex, and HR 5780 have derived abundances similar to those of other normal sharp-lined stars of similar effective temperature.

A machine learning method for fast and accurate characterization of depth-of-interaction gamma cameras

NASA Astrophysics Data System (ADS)

Pedemonte, Stefano; Pierce, Larry; Van Leemput, Koen

2017-11-01

Measuring the depth-of-interaction (DOI) of gamma photons enables increasing the resolution of emission imaging systems. Several design variants of DOI-sensitive detectors have been recently introduced to improve the performance of scanners for positron emission tomography (PET). However, the accurate characterization of the response of DOI detectors, necessary to accurately measure the DOI, remains an unsolved problem. Numerical simulations are, at the state of the art, imprecise, while measuring directly the characteristics of DOI detectors experimentally is hindered by the impossibility to impose the depth-of-interaction in an experimental set-up. In this article we introduce a machine learning approach for extracting accurate forward models of gamma imaging devices from simple pencil-beam measurements, using a nonlinear dimensionality reduction technique in combination with a finite mixture model. The method is purely data-driven, not requiring simulations, and is applicable to a wide range of detector types. The proposed method was evaluated both in a simulation study and with data acquired using a monolithic gamma camera designed for PET (the cMiCE detector), demonstrating the accurate recovery of the DOI characteristics. The combination of the proposed calibration technique with maximum- a posteriori estimation of the coordinates of interaction provided a depth resolution of  ≈1.14 mm for the simulated PET detector and  ≈1.74 mm for the cMiCE detector. The software and experimental data are made available at http://occiput.mgh.harvard.edu/depthembedding/.

Single-view 3D reconstruction of correlated gamma-neutron sources

DOE PAGES

Monterial, Mateusz; Marleau, Peter; Pozzi, Sara A.

2017-01-05

We describe a new method of 3D image reconstruction of neutron sources that emit correlated gammas (e.g. Cf- 252, Am-Be). This category includes a vast majority of neutron sources important in nuclear threat search, safeguards and non-proliferation. Rather than requiring multiple views of the source this technique relies on the source’s intrinsic property of coincidence gamma and neutron emission. As a result only a single-view measurement of the source is required to perform the 3D reconstruction. In principle, any scatter camera sensitive to gammas and neutrons with adequate timing and interaction location resolution can perform this reconstruction. Using a neutronmore » double scatter technique, we can calculate a conical surface of possible source locations. By including the time to a correlated gamma we further constrain the source location in three-dimensions by solving for the source-to-detector distance along the surface of said cone. As a proof of concept we applied these reconstruction techniques on measurements taken with the the Mobile Imager of Neutrons for Emergency Responders (MINER). Two Cf-252 sources measured at 50 and 60 cm from the center of the detector were resolved in their varying depth with average radial distance relative resolution of 26%. To demonstrate the technique’s potential with an optimized system we simulated the measurement in MCNPX-PoliMi assuming timing resolution of 200 ps (from 2 ns in the current system) and source interaction location resolution of 5 mm (from 3 cm). Furthermore, these simulated improvements in scatter camera performance resulted in radial distance relative resolution decreasing to an average of 11%.« less

Single-view 3D reconstruction of correlated gamma-neutron sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Monterial, Mateusz; Marleau, Peter; Pozzi, Sara A.

We describe a new method of 3D image reconstruction of neutron sources that emit correlated gammas (e.g. Cf- 252, Am-Be). This category includes a vast majority of neutron sources important in nuclear threat search, safeguards and non-proliferation. Rather than requiring multiple views of the source this technique relies on the source’s intrinsic property of coincidence gamma and neutron emission. As a result only a single-view measurement of the source is required to perform the 3D reconstruction. In principle, any scatter camera sensitive to gammas and neutrons with adequate timing and interaction location resolution can perform this reconstruction. Using a neutronmore » double scatter technique, we can calculate a conical surface of possible source locations. By including the time to a correlated gamma we further constrain the source location in three-dimensions by solving for the source-to-detector distance along the surface of said cone. As a proof of concept we applied these reconstruction techniques on measurements taken with the the Mobile Imager of Neutrons for Emergency Responders (MINER). Two Cf-252 sources measured at 50 and 60 cm from the center of the detector were resolved in their varying depth with average radial distance relative resolution of 26%. To demonstrate the technique’s potential with an optimized system we simulated the measurement in MCNPX-PoliMi assuming timing resolution of 200 ps (from 2 ns in the current system) and source interaction location resolution of 5 mm (from 3 cm). Furthermore, these simulated improvements in scatter camera performance resulted in radial distance relative resolution decreasing to an average of 11%.« less

Thyroid Scan and Uptake

MedlinePlus

... minutes prior to the test. When it is time for the imaging to begin, you will lie down on a moveable examination table with your head tipped backward and neck extended. The gamma camera will then take a series of images, capturing images of the thyroid gland ...

Gamma-camera 18F-FDG PET in diagnosis and staging of patients presenting with suspected lung cancer and comparison with dedicated PET.

PubMed

Oturai, Peter S; Mortensen, Jann; Enevoldsen, Henriette; Eigtved, Annika; Backer, Vibeke; Olesen, Knud P; Nielsen, Henrik W; Hansen, Hanne; Stentoft, Poul; Friberg, Lars

2004-08-01

It is not clear whether high-quality coincidence gamma-PET (gPET) cameras can provide clinical data comparable with data obtained with dedicated PET (dPET) cameras in the primary diagnostic work-up of patients with suspected lung cancer. This study focuses on 2 main issues: direct comparison between foci resolved with the 2 different PET scanners and the diagnostic accuracy compared with final diagnosis determined by the combined information from all other investigations and clinical follow-up. Eighty-six patients were recruited to this study through a routine diagnostic program. They all had changes on their chest radiographs, suggesting malignant lung tumor. In addition to the standard diagnostic program, each patient had 2 PET scans that were performed on the same day. After administration of 419 MBq (range = 305-547 MBq) (18)F-FDG, patients were scanned in a dedicated PET scanner about 1 h after FDG administration and in a dual-head coincidence gamma-camera about 3 h after tracer injection. Images from the 2 scans were evaluated in a blinded set-up and compared with the final outcome. Malignant intrathoracic disease was found in 52 patients, and 47 patients had primary lung cancers. dPET detected all patients as having malignancies (sensitivity, 100%; specificity, 50%), whereas gPET missed one patient (sensitivity, 98%; specificity, 56%). For evaluating regional lymph node involvement, sensitivity and specificity rates were 78% and 84% for dPET and 61% and 90% for gPET, respectively. When comparing the 2 PET techniques with clinical tumor stage (TNM), full agreement was obtained in 64% of the patients (Cohen's kappa = 0.56). Comparing categorization of the patients into clinical relevant stages (no malignancy/malignancy suitable for treatment with curative intent/nontreatable malignancy), resulted in full agreement in 81% (Cohen's kappa = 0.71) of patients. Comparing results from a recent generation of gPET cameras obtained about 2 h later than those of dPET, there was a fairly good agreement with regard to detecting primary lung tumors but slightly reduced sensitivity in detecting smaller malignant lesions such as lymph nodes. Depending on the population to be investigated, and if dPET is not available, gPET might provide significant diagnostic information in patients in whom lung cancer is suspected.

Neutron Imaging Camera

NASA Technical Reports Server (NTRS)

Hunter, Stanley; deNolfo, G. A.; Barbier, L. M.; Link, J. T.; Son, S.; Floyd, S. R.; Guardala, N.; Skopec, M.; Stark, B.

2008-01-01

The Neutron Imaging Camera (NIC) is based on the Three-dimensional Track Imager (3DTI) technology developed at GSFC for gamma-ray astrophysics applications. The 3-DTI, a large volume time-projection chamber, provides accurate, approximately 0.4 mm resolution, 3-D tracking of charged particles. The incident direction of fast neutrons, En > 0.5 MeV, are reconstructed from the momenta and energies of the proton and triton fragments resulting from (sup 3)He(n,p) (sup 3)H interactions in the 3-DTI volume. The performance of the NIC from laboratory and accelerator tests is presented.

Development of a Compton camera for medical applications based on silicon strip and scintillation detectors

NASA Astrophysics Data System (ADS)

Krimmer, J.; Ley, J.-L.; Abellan, C.; Cachemiche, J.-P.; Caponetto, L.; Chen, X.; Dahoumane, M.; Dauvergne, D.; Freud, N.; Joly, B.; Lambert, D.; Lestand, L.; Létang, J. M.; Magne, M.; Mathez, H.; Maxim, V.; Montarou, G.; Morel, C.; Pinto, M.; Ray, C.; Reithinger, V.; Testa, E.; Zoccarato, Y.

2015-07-01

A Compton camera is being developed for the purpose of ion-range monitoring during hadrontherapy via the detection of prompt-gamma rays. The system consists of a scintillating fiber beam tagging hodoscope, a stack of double sided silicon strip detectors (90×90×2 mm3, 2×64 strips) as scatter detectors, as well as bismuth germanate (BGO) scintillation detectors (38×35×30 mm3, 100 blocks) as absorbers. The individual components will be described, together with the status of their characterization.

A panoramic coded aperture gamma camera for radioactive hotspots localization

NASA Astrophysics Data System (ADS)

Paradiso, V.; Amgarou, K.; Blanc De Lanaute, N.; Schoepff, V.; Amoyal, G.; Mahe, C.; Beltramello, O.; Liénard, E.

2017-11-01

A known disadvantage of the coded aperture imaging approach is its limited field-of-view (FOV), which often results insufficient when analysing complex dismantling scenes such as post-accidental scenarios, where multiple measurements are needed to fully characterize the scene. In order to overcome this limitation, a panoramic coded aperture γ-camera prototype has been developed. The system is based on a 1 mm thick CdTe detector directly bump-bonded to a Timepix readout chip, developed by the Medipix2 collaboration (256 × 256 pixels, 55 μm pitch, 14.08 × 14.08 mm2 sensitive area). A MURA pattern coded aperture is used, allowing for background subtraction without the use of heavy shielding. Such system is then combined with a USB color camera. The output of each measurement is a semi-spherical image covering a FOV of 360 degrees horizontally and 80 degrees vertically, rendered in spherical coordinates (θ,phi). The geometrical shapes of the radiation-emitting objects are preserved by first registering and stitching the optical images captured by the prototype, and applying, subsequently, the same transformations to their corresponding radiation images. Panoramic gamma images generated by using the technique proposed in this paper are described and discussed, along with the main experimental results obtained in laboratories campaigns.

A neutron camera system for MAST.

PubMed

Cecconello, M; Turnyanskiy, M; Conroy, S; Ericsson, G; Ronchi, E; Sangaroon, S; Akers, R; Fitzgerald, I; Cullen, A; Weiszflog, M

2010-10-01

A prototype neutron camera has been developed and installed at MAST as part of a feasibility study for a multichord neutron camera system with the aim to measure the spatial and time resolved 2.45 MeV neutron emissivity profile. Liquid scintillators coupled to a fast digitizer are used for neutron/gamma ray digital pulse shape discrimination. The preliminary results obtained clearly show the capability of this diagnostic to measure neutron emissivity profiles with sufficient time resolution to study the effect of fast ion loss and redistribution due to magnetohydrodynamic activity. A minimum time resolution of 2 ms has been achieved with a modest 1.5 MW of neutral beam injection heating with a measured neutron count rate of a few 100 kHz.

Hybrid radioguided occult lesion localization (hybrid ROLL) of (18)F-FDG-avid lesions using the hybrid tracer indocyanine green-(99m)Tc-nanocolloid.

PubMed

KleinJan, G H; Brouwer, O R; Mathéron, H M; Rietbergen, D D D; Valdés Olmos, R A; Wouters, M W; van den Berg, N S; van Leeuwen, F W B

2016-01-01

To assess if combined fluorescence- and radio-guided occult lesion localization (hybrid ROLL) is feasible in patients scheduled for surgical resection of non-palpable (18)F-FDG-avid lesions on PET/CT. Four patients with (18)F-FDG-avid lesions on follow-up PET/CT that were not palpable during physical examination but were suspected to harbor metastasis were enrolled. Guided by ultrasound, the hybrid tracer indocyanine green (ICG)-(99m)Tc-nanocolloid was injected centrally in the target lesion. SPECT/CT imaging was used to confirm tracer deposition. Intraoperatively, lesions were localized using a hand-held gamma ray detection probe, a portable gamma camera, and a fluorescence camera. After excision, the gamma camera was used to check the wound bed for residual activity. A total of six (18)F-FDG-avid lymph nodes were identified and scheduled for hybrid ROLL. Comparison of the PET/CT images with the acquired SPECT/CT after hybrid tracer injection confirmed accurate tracer deposition. No side effects were observed. Combined radio- and fluorescence-guidance enabled localization and excision of the target lesion in all patients. Five of the six excised lesions proved tumor-positive at histopathology. The hybrid ROLL approach appears to be feasible and can facilitate the intraoperative localization and excision of non-palpable lesions suspected to harbor tumor metastases. In addition to the initial radioguided detection, the fluorescence component of the hybrid tracer enables high-resolution intraoperative visualization of the target lesion. The procedure needs further evaluation in a larger cohort and wider range of malignancies to substantiate these preliminary findings. Copyright © 2016 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

Development of an intraoperative gamma camera based on a 256-pixel mercuric iodide detector array

NASA Astrophysics Data System (ADS)

Patt, B. E.; Tornai, M. P.; Iwanczyk, J. S.; Levin, C. S.; Hoffman, E. J.

1997-06-01

A 256-element mercuric iodide (HgI/sub 2/) detector array has been developed which is intended for use as an intraoperative gamma camera (IOGC). The camera is specifically designed for use in imaging gamma-emitting radiopharmaceuticals (such as 99m-Tc labeled Sestamibi) incorporated into brain tumors in the intraoperative surgical environment. The system is intended to improve the success of tumor removal surgeries by allowing more complete removal of subclinical tumor cells without removal of excessive normal tissue. The use of HgI/sub 2/ detector arrays in this application facilitates construction of an imaging head that is very compact and has a high SNR. The detector is configured as a cross-grid array. Pixel dimensions are 1.25 mm squares separated by 0.25 mm. The overall dimension of the detector is 23.75 mm on a side. The detector thickness is 1 mm which corresponds to over 60% stopping at 140 keV. The array has good uniformity with average energy resolution of 5.2/spl plusmn/2.9% FWHM at 140 keV (best resolution was 1.9% FWHM). Response uniformity (/spl plusmn//spl sigma/) was 7.9%. A study utilizing realistic tumor phantoms (uptake ratio varied from 2:1 to 100:1) in background (1 mCi/l) was conducted. SNRs for the reasonably achievable uptake ratio of 50:1 were 5.61 /spl sigma/ with 1 cm of background depth ("normal tissue") and 2.74 /spl sigma/ with 4 cm of background for a 6.3 /spl mu/l tumor phantom (/spl sim/270 nCi at the time of the measurement).

Continuous on-line monitoring of left ventricular function with a new nonimaging detector:validation and clinical use in the evaluation of patients post angioplasty.

PubMed

Breisblatt, W M; Schulman, D S; Follansbee, W P

1991-06-01

A new miniaturized nonimaging radionuclide detector (Cardioscint, Oxford, England) was evaluated for the continuous on-line assessment of left ventricular function. This cesium iodide probe can be placed on the patient's chest and can be interfaced to an IBM compatible personal computer conveniently placed at the patient's bedside. This system can provide a beat-to-beat or gated determination of left ventricular ejection fraction and ST segment analysis. In 28 patients this miniaturized probe was correlated against a high resolution gamma camera study. Over a wide range of ejection fraction (31% to 76%) in patients with and without regional wall motion abnormalities, the correlation between the Cardioscint detector and the gamma camera was excellent (r = 0.94, SEE +/- 2.1). This detector system has high temporal (10 msec) resolution, and comparison of peak filling rate (PFR) and time to peak filling (TPFR) also showed close agreement with the gamma camera (PFR, r = 0.94, SEE +/- 0.17; TPFR, r = 0.92, SEE +/- 6.8). In 18 patients on bed rest the long-term stability of this system for measuring ejection fraction and ST segments was verified. During the monitoring period (108 +/- 28 minutes) only minor changes in ejection fraction occurred (coefficient of variation 0.035 +/- 0.016) and ST segment analysis showed no significant change from baseline. To determine whether continuous on-line measurement of ejection fraction would be useful after coronary angioplasty, 12 patients who had undergone a successful procedure were evaluated for 280 +/- 35 minutes with the Cardioscint system.(ABSTRACT TRUNCATED AT 250 WORDS)

The next evolution in radioguided surgery: breast cancer related sentinel node localization using a freehandSPECT-mobile gamma camera combination

PubMed Central

Engelen, Thijs; Winkel, Beatrice MF; Rietbergen, Daphne DD; KleinJan, Gijs H; Vidal-Sicart, Sergi; Olmos, Renato A Valdés; van den Berg, Nynke S; van Leeuwen, Fijs WB

2015-01-01

Accurate pre- and intraoperative identification of the sentinel node (SN) forms the basis of the SN biopsy procedure. Gamma tracing technologies such as a gamma probe (GP), a 2D mobile gamma camera (MGC) or 3D freehandSPECT (FHS) can be used to provide the surgeon with radioguidance to the SN(s). We reasoned that integrated use of these technologies results in the generation of a “hybrid” modality that combines the best that the individual radioguidance technologies have to offer. The sensitivity and resolvability of both 2D-MGC and 3D-FHS-MGC were studied in a phantom setup (at various source-detector depths and using varying injection site-to-SN distances), and in ten breast cancer patients scheduled for SN biopsy. Acquired 3D-FHS-MGC images were overlaid with the position of the phantom/patient. This augmented-reality overview image was then used for navigation to the hotspot/SN in virtual-reality using the GP. Obtained results were compared to conventional gamma camera lymphoscintigrams. Resolution of 3D-FHS-MGC allowed identification of the SNs at a minimum injection site (100 MBq)-to-node (1 MBq; 1%) distance of 20 mm, up to a source-detector depth of 36 mm in 2D-MGC and up to 24 mm in 3D-FHS-MGC. A clinically relevant dose of approximately 1 MBq was clearly detectable up to a depth of 60 mm in 2D-MGC and 48 mm in 3D-FHS-MGC. In all ten patients at least one SN was visualized on the lymphoscintigrams with a total of 12 SNs visualized. 3D-FHS-MGC identified 11 of 12 SNs and allowed navigation to all these visualized SNs; in one patient with two axillary SNs located closely to each other (11 mm), 3D-FHS-MGC was not able to distinguish the two SNs. In conclusion, high sensitivity detection of SNs at an injection site-to-node distance of 20 mm-and-up was possible using 3D-FHS-MGC. In patients, 3D-FHS-MGC showed highly reproducible images as compared to the conventional lymphoscintigrams. PMID:26069857

Localization and spectral isolation of special nuclear material using stochastic image reconstruction

NASA Astrophysics Data System (ADS)

Hamel, M. C.; Polack, J. K.; Poitrasson-Rivière, A.; Clarke, S. D.; Pozzi, S. A.

2017-01-01

In this work we present a technique for isolating the gamma-ray and neutron energy spectra from multiple radioactive sources localized in an image. Image reconstruction algorithms for radiation scatter cameras typically focus on improving image quality. However, with scatter cameras being developed for non-proliferation applications, there is a need for not only source localization but also source identification. This work outlines a modified stochastic origin ensembles algorithm that provides localized spectra for all pixels in the image. We demonstrated the technique by performing three experiments with a dual-particle imager that measured various gamma-ray and neutron sources simultaneously. We showed that we could isolate the peaks from 22Na and 137Cs and that the energy resolution is maintained in the isolated spectra. To evaluate the spectral isolation of neutrons, a 252Cf source and a PuBe source were measured simultaneously and the reconstruction showed that the isolated PuBe spectrum had a higher average energy and a greater fraction of neutrons at higher energies than the 252Cf. Finally, spectrum isolation was used for an experiment with weapons grade plutonium, 252Cf, and AmBe. The resulting neutron and gamma-ray spectra showed the expected characteristics that could then be used to identify the sources.

Design Studies of a CZT-based Detector Combined with a Pixel-Geometry-Matching Collimator for SPECT Imaging.

PubMed

Weng, Fenghua; Bagchi, Srijeeta; Huang, Qiu; Seo, Youngho

2013-10-01

Single Photon Emission Computed Tomography (SPECT) suffers limited efficiency due to the need for collimators. Collimator properties largely decide the data statistics and image quality. Various materials and configurations of collimators have been investigated in many years. The main thrust of our study is to evaluate the design of pixel-geometry-matching collimators to investigate their potential performances using Geant4 Monte Carlo simulations. Here, a pixel-geometry-matching collimator is defined as a collimator which is divided into the same number of pixels as the detector's and the center of each pixel in the collimator is a one-to-one correspondence to that in the detector. The detector is made of Cadmium Zinc Telluride (CZT), which is one of the most promising materials for applications to detect hard X-rays and γ -rays due to its ability to obtain good energy resolution and high light output at room temperature. For our current project, we have designed a large-area, CZT-based gamma camera (20.192 cm×20.192 cm) with a small pixel pitch (1.60 mm). The detector is pixelated and hence the intrinsic resolution can be as small as the size of the pixel. Materials of collimator, collimator hole geometry, detection efficiency, and spatial resolution of the CZT detector combined with the pixel-matching collimator were calculated and analyzed under different conditions. From the simulation studies, we found that such a camera using rectangular holes has promising imaging characteristics in terms of spatial resolution, detection efficiency, and energy resolution.

[Diagnostic use of positron emission tomography in France: from the coincidence gamma-camera to mobile hybrid PET/CT devices].

PubMed

Talbot, Jean-Noël

2010-11-01

Positron emission tomography (PET) is a well-established medical imaging method. PET is increasingly used for diagnostic purposes, especially in oncology. The most widely used radiopharmaceutical is FDG, a glucose analogue. Other radiopharmaceuticals have recently been registered or are in development. We outline technical improvements of PET machines during more than a decade of clinical use in France. Even though image quality has improved considerably and PET-CT hybrid machines have emerged, spending per examination has remained remarkably constant. Replacement and maintenance costs have remained in the range of 170-190 Euros per examination since 1997, whether early CDET gamma cameras or the latest time-of-flight PET/CT devices are used. This is mainly due to shorter acquisition times and more efficient use of FDG New reimbursement rates for PET/CT are needed in France in order to favor regular acquisition of state-of-the-art devices. One major development is the coupling of PET and MR imaging.

Evaluation of a gamma camera system for the RITS-6 accelerator using the self-magnetic pinch diode

NASA Astrophysics Data System (ADS)

Webb, Timothy J.; Kiefer, Mark L.; Gignac, Raymond; Baker, Stuart A.

2015-08-01

The self-magnetic pinch (SMP) diode is an intense radiographic source fielded on the Radiographic Integrated Test Stand (RITS-6) accelerator at Sandia National Laboratories in Albuquerque, NM. The accelerator is an inductive voltage adder (IVA) that can operate from 2-10 MV with currents up to 160 kA (at 7 MV). The SMP diode consists of an annular cathode separated from a flat anode, holding the bremsstrahlung conversion target, by a vacuum gap. Until recently the primary imaging diagnostic utilized image plates (storage phosphors) which has generally low DQE at these photon energies along with other problems. The benefits of using image plates include a high-dynamic range, good spatial resolution, and ease of use. A scintillator-based X-ray imaging system or "gamma camera" has been fielded in front of RITS and the SMP diode which has been able to provide vastly superior images in terms of signal-to-noise with similar resolution and acceptable dynamic range.

System of Programmed Modules for Measuring Photographs with a Gamma-Telescope

NASA Technical Reports Server (NTRS)

Averin, S. A.; Veselova, G. V.; Navasardyan, G. V.

1978-01-01

Physical experiments using tracking cameras resulted in hundreds of thousands of stereo photographs of events being received. To process such a large volume of information, automatic and semiautomatic measuring systems are required. At the Institute of Space Research of the Academy of Science of the USSR, a system for processing film information from the spark gamma-telescope was developed. The system is based on a BPS-75 projector in line with the minicomputer Elektronika 1001. The report describes this system. The various computer programs available to the operators are discussed.

A Robotic arm for optical and gamma radwaste inspection

NASA Astrophysics Data System (ADS)

Russo, L.; Cosentino, L.; Pappalardo, A.; Piscopo, M.; Scirè, C.; Scirè, S.; Vecchio, G.; Muscato, G.; Finocchiaro, P.

2014-12-01

We propose Radibot, a simple and cheap robotic arm for remote inspection, which interacts with the radwaste environment by means of a scintillation gamma detector and a video camera representing its light (< 1 kg) payload. It moves vertically thanks to a crane, while the other three degrees of freedom are obtained by means of revolute joints. A dedicated algorithm allows to automatically choose the best kinematics in order to reach a graphically selected position, while still allowing to fully drive the arm by means of a standard videogame joypad.

Comment on 'Imaging of prompt gamma rays emitted during delivery of clinical proton beams with a Compton camera: feasibility studies for range verification'.

PubMed

Sitek, Arkadiusz

2016-12-21

The origin ensemble (OE) algorithm is a new method used for image reconstruction from nuclear tomographic data. The main advantage of this algorithm is the ease of implementation for complex tomographic models and the sound statistical theory. In this comment, the author provides the basics of the statistical interpretation of OE and gives suggestions for the improvement of the algorithm in the application to prompt gamma imaging as described in Polf et al (2015 Phys. Med. Biol. 60 7085).

Comment on ‘Imaging of prompt gamma rays emitted during delivery of clinical proton beams with a Compton camera: feasibility studies for range verification’

NASA Astrophysics Data System (ADS)

Sitek, Arkadiusz

2016-12-01

The origin ensemble (OE) algorithm is a new method used for image reconstruction from nuclear tomographic data. The main advantage of this algorithm is the ease of implementation for complex tomographic models and the sound statistical theory. In this comment, the author provides the basics of the statistical interpretation of OE and gives suggestions for the improvement of the algorithm in the application to prompt gamma imaging as described in Polf et al (2015 Phys. Med. Biol. 60 7085).

Monitoring the distribution of prompt gamma rays in boron neutron capture therapy using a multiple-scattering Compton camera: A Monte Carlo simulation study

NASA Astrophysics Data System (ADS)

Lee, Taewoong; Lee, Hyounggun; Lee, Wonho

2015-10-01

This study evaluated the use of Compton imaging technology to monitor prompt gamma rays emitted by 10B in boron neutron capture therapy (BNCT) applied to a computerized human phantom. The Monte Carlo method, including particle-tracking techniques, was used for simulation. The distribution of prompt gamma rays emitted by the phantom during irradiation with neutron beams is closely associated with the distribution of the boron in the phantom. Maximum likelihood expectation maximization (MLEM) method was applied to the information obtained from the detected prompt gamma rays to reconstruct the distribution of the tumor including the boron uptake regions (BURs). The reconstructed Compton images of the prompt gamma rays were combined with the cross-sectional images of the human phantom. Quantitative analysis of the intensity curves showed that all combined images matched the predetermined conditions of the simulation. The tumors including the BURs were distinguishable if they were more than 2 cm apart.

First Test Of A New High Resolution Positron Camera With Four Area Detectors

NASA Astrophysics Data System (ADS)

van Laethem, E.; Kuijk, M.; Deconinck, Frank; van Miert, M.; Defrise, Michel; Townsend, D.; Wensveen, M.

1989-10-01

A PET camera consisting of two pairs of parallel area detectors has been installed at the cyclotron unit of VUB. The detectors are High Density Avalanche Chambers (HIDAC) wire-chambers with a stack of 4 or 6 lead gamma-electron converters, the sensitive area being 30 by 30 cm. The detectors are mounted on a commercial gantry allowing a 180 degree rotation during acquisition, as needed for a fully 3D image reconstruction. The camera has been interfaced to a token-ring computer network consisting of 5 workstations among which the various tasks (acquisition, reconstruction, display) can be distributed. Each coincident event is coded in 48 bits and is transmitted to the computer bus via a 512 kbytes dual ported buffer memory allowing data rates of up to 50 kHz. Fully 3D image reconstruction software has been developed, and includes new reconstruction algorithms allowing a better utilization of the available projection data. Preliminary measurements and imaging of phantoms and small animals (with 18FDG) have been performed with two of the four detectors mounted on the gantry. They indicate the expected 3D isotropic spatial resolution of 3.5 mm (FWHM, line source in air) and a sensitivity of 4 cps/μCi for a centred point source in air, corresponding to typical data rates of a few kHz. This latter figure is expected to improve by a factor of 4 after coupling of the second detector pair, since the coincidence sensitivity of this second detector pair is a factor 3 higher than that of the first one.

Imaging probe for breast cancer localization

NASA Astrophysics Data System (ADS)

Soluri, A.; Scafè, R.; Capoccetti, F.; Burgio, N.; Schiaratura, A.; Pani, R.; Pellegrini, R.; Cinti, M. N.; Mechella, M.; Amanti, A.; David, V.; Scopinaro, F.

2003-01-01

High spatial resolution, small Field Of View (FOV), fully portable scintillation cameras are lower cost and obviously lower weight than large FOV, not transportable Anger gamma cameras. Portable cameras allow easy transfer of the detector, thus of radioisotope imaging, where the bioptical procedure takes place. In this paper we describe a preliminary experience on radionuclide Breast Cancer (BC) imaging with a 22.8×22.8 mm 2 FOV minicamera, already used by our group for sentinel node detection with the name of Imaging Probe (IP). In this work IP BC detection was performed with the aim of guiding biopsy, in particular open biopsy, or to help or modify fine needle or needle addressing when main driving method was echography or digital radiography. The IP prototype weight was about 1 kg. This small scintillation camera is based on the compact Position Sensitive Photomultiplier Tube Hamamatsu R7600-00-C8, coupled to a CsI(Tl) scintillation array 2.6×2.6×5.0 mm 3 crystal-pixel size. Spatial resolution of the IP was 2.5 mm Full-Width at Half-Maximum at laboratory tests. IP was provided with acquisition software allowing quick change of pixels number on the computer acquisition frame and an on-line image-smoothing program. Both these programs were developed in order to allow nuclear physicians to quickly get target source when the patient was anesthetized in the operator room, with sterile conditions. 99mTc Sestamibi (MIBI) was injected at the dose of 740 MBq 1 h before imaging and biopsy to 14 patients with suspicious or known BC. Scintigraphic images were acquired before and after biopsy in each patient. Operator was allowed to take into account scintigraphic images as well as previously performed X-ray mammograms and echographies. High-resolution IP images were able to guide biopsy toward cancer or washout zones of the cancer, that are thought to be chemoresistant in 7 patients out of 10. Four patients, in whom IP and MIBI were not able to guide biopsy, did not show cancer. Two patients in whom biopsy was performed in the high washout zone, did show Multi Drug Resistance (MDR) gene product at immunohistochemistry on bioptical samples. Specific radioactivity was measured on biopsy specimens and measurement confirmed the etherogeneous distribution of MIBI within cancers. Our study confirms the ability of IP to guide breast biopsy even when our mini-camera has to be manually handled by trained physicians during operation.

Highlights of recent results from the VERITAS gamma-ray observatory

NASA Astrophysics Data System (ADS)

Fortson, Lucy; VERITAS Collaboration

2016-05-01

VERITAS is a major ground-based gamma-ray observatory comprising an array of four 12 meter air Cherenkov telescopes operating at the Fred Lawrence Whipple Observatory near Tucson, Arizona. Data taking has continued from 2007 with a major camera upgrade completed in 2012 resulting in the current sensitivity to very-high-energy (VHE) gamma rays between 85 GeV and 30 TeV. VERITAS has detected 54 sources (half of which have been discoveries) leading to many significant contributions to the field of VHE astronomy. These proceedings highlight some of the more recent VERITAS results from the blazar and galactic observing programs as well as measurements of the cosmic-ray electron spectrum, constraints on dark matter and a follow-up program for astrophysical neutrinos.

Focal Plane Detectors for the Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Wagner, R. G.; Byrum, K.; Drake, G.; Funk, S.; Otte, N.; Smith, A.; Tajima, H.; Williams, D.

2009-05-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. It is being designed to achieve a significant improvement in sensitivity compared to current Imaging Air Cherenkov Telescope (IACT) Arrays. One of the main requirements in order that AGIS fulfills this goal will be to achieve higher angular resolution than current IACTs. Simulations show that a substantial improvement in angular resolution may be achieved if the pixel size is reduced to 0.05 deg, i.e. two to three times smaller than for current IACT cameras. Here we present results from testing of alternatives being considered for AGIS, including both silicon photomultipliers (SiPMs) and multi-anode photomultipliers (MAPMTs).

Evaluation of the ImmerVision IMV1-1/3NI Panomorph Lens on a Small Unmanned Ground Vehicle (SUGV)

DTIC Science & Technology

2013-07-01

360°. For the above reason, a 1.3-MP Chameleon color universal serial bus (USB) camera with a 1/3-in CCD from PGR was selected instead of...recommended qualified cameras to host the panomorph lens. Having the advantage of a small footprint, the Chameleon camera with the IMV1 lens can be easily

Ambient Dose Equivalent measured at the Instituto Nacional de Cancerología Department of Nuclear Medicine

NASA Astrophysics Data System (ADS)

Ávila, O.; Torres-Ulloa, C. L.; Medina, L. A.; Trujillo-Zamudio, F. E.; de Buen, I. Gamboa; Buenfil, A. E.; Brandan, M. E.

2010-12-01

Ambient dose equivalent values were determined in several sites at the Instituto Nacional de Cancerología, Departmento de Medicina Nuclear, using TLD-100 and TLD-900 thermoluminescent dosemeters. Additionally, ambient dose equivalent was measured at a corridor outside the hospitalization room for patients treated with 137Cs brachytherapy. Dosemeter calibration was performed at the Instituto Nacional de Investigaciones Nucleares, Laboratorio de Metrología, to known 137Cs gamma radiation air kerma. Radionuclides considered for this study are 131I, 18F, 67Ga, 99mTc, 111In, 201Tl and 137Cs, with main gamma energies between 93 and 662 keV. Dosemeters were placed during a five month period in the nuclear medicine rooms (containing gamma-cameras), injection corridor, patient waiting areas, PET/CT study room, hot lab, waste storage room and corridors next to the hospitalization rooms for patients treated with 131I and 137Cs. High dose values were found at the waste storage room, outside corridor of 137Cs brachytherapy patients and PET/CT area. Ambient dose equivalent rate obtained for the 137Cs brachytherapy corridor is equal to (18.51±0.02)×10-3 mSv/h. Sites with minimum doses are the gamma camera rooms, having ambient dose equivalent rates equal to (0.05±0.03)×10-3 mSv/h. Recommendations have been given to the Department authorities so that further actions are taken to reduce doses at high dose sites in order to comply with the ALARA principle (as low as reasonably achievable).

Development of compact Compton camera for 3D image reconstruction of radioactive contamination

NASA Astrophysics Data System (ADS)

Sato, Y.; Terasaka, Y.; Ozawa, S.; Nakamura Miyamura, H.; Kaburagi, M.; Tanifuji, Y.; Kawabata, K.; Torii, T.

2017-11-01

The Fukushima Daiichi Nuclear Power Station (FDNPS), operated by Tokyo Electric Power Company Holdings, Inc., went into meltdown after the large tsunami caused by the Great East Japan Earthquake of March 11, 2011. Very large amounts of radionuclides were released from the damaged plant. Radiation distribution measurements inside FDNPS buildings are indispensable to execute decommissioning tasks in the reactor buildings. We have developed a compact Compton camera to measure the distribution of radioactive contamination inside the FDNPS buildings three-dimensionally (3D). The total weight of the Compton camera is lower than 1.0 kg. The gamma-ray sensor of the Compton camera employs Ce-doped GAGG (Gd3Al2Ga3O12) scintillators coupled with a multi-pixel photon counter. Angular correction of the detection efficiency of the Compton camera was conducted. Moreover, we developed a 3D back-projection method using the multi-angle data measured with the Compton camera. We successfully observed 3D radiation images resulting from the two 137Cs radioactive sources, and the image of the 9.2 MBq source appeared stronger than that of the 2.7 MBq source.

STS-37 Breakfast / Ingress / Launch & ISO Camera Views

NASA Technical Reports Server (NTRS)

1991-01-01

The primary objective of the STS-37 mission was to deploy the Gamma Ray Observatory. The mission was launched at 9:22:44 am on April 5, 1991, onboard the space shuttle Atlantis. The mission was led by Commander Steven Nagel. The crew was Pilot Kenneth Cameron and Mission Specialists Jerry Ross, Jay Apt, and Linda Godwing. This videotape shows the crew having breakfast on the launch day, with the narrator introducing them. It then shows the crew's final preparations and the entry into the shuttle, while the narrator gives information about each of the crew members. The countdown and launch is shown including the shuttle separation from the solid rocket boosters. The launch is reshown from 17 different camera views. Some of the other camera views were in black and white.

A data acquisition system for coincidence imaging using a conventional dual head gamma camera

NASA Astrophysics Data System (ADS)

Lewellen, T. K.; Miyaoka, R. S.; Jansen, F.; Kaplan, M. S.

1997-06-01

A low cost data acquisition system (DAS) was developed to acquire coincidence data from an unmodified General Electric Maxxus dual head scintillation camera. A high impedance pick-off circuit provides position and energy signals to the DAS without interfering with normal camera operation. The signals are pulse-clipped to reduce pileup effects. Coincidence is determined with fast timing signals derived from constant fraction discriminators. A charge-integrating FERA 16 channel ADC feeds position and energy data to two CAMAC FERA memories operated as ping-pong buffers. A Macintosh PowerPC running Labview controls the system and reads the CAMAC memories. A CAMAC 12-channel scaler records singles and coincidence rate data. The system dead-time is approximately 10% at a coincidence rate of 4.0 kHz.

Model analysis for the MAGIC telescope

NASA Astrophysics Data System (ADS)

Mazin, D.; Bigongiari, C.; Goebel, F.; Moralejo, A.; Wittek, W.

The MAGIC Collaboration operates the 17m imaging Cherenkov telescope on the Canary island La Palma. The main goal of the experiment is an energy threshold below 100 GeV for primary gamma rays. The new analysis technique (model analysis) takes advantage of the high resolution (both in space and time) camera by fitting the averaged expected templates of the shower development to the measured shower images in the camera. This approach allows to recognize and reconstruct images just above the level of the night sky background light fluctuations. Progress and preliminary results of the model analysis technique will be presented.

AIRWAY RETENTION OF MATERIALS OF DIFFERENT SOLUBILITY FOLLOWING LOCAL INTRABRONCHIAL DEPOSITION IN DOGS

EPA Science Inventory

We used a gamma camera to monitor the retention and clearance of radiolabeled human serum albumin (HSA), a water-soluble material with molecular weight of 66,000 Daltons, and radiolabeled sulfur colloid (SC), an insoluble submicron (0.22 microm) particle, following localized depo...

Investigation of a potential macromolecular MRI contrast agent prepared from PPI (G = 2, polypropyleneimine, generation 2) dendrimer bifunctional chelates

NASA Astrophysics Data System (ADS)

Wang, Jianxin Steven

The long-term objective is to develop magnetic resonance (MR) contrast agents that actively and passively target tumors for diagnosis and therapy. Many diagnostic imaging techniques for cancer lack specificity. A dendrimer based magnetic resonance imaging contrast agent has been developed with large proton relaxation enhancements and high molecular relaxivities. A new type of linear dendrimer based MRI contrast agent that is built from the polypropyleneimine and polyamidoamine dendrimers in which free amines have been conjugated to the chelate DTPA, which further formed the complex with Gadolinium (Gd) was studied. The specific research goals were to test the hypothesis that a linear chelate with macromolecular agents can be used in vitro and in vivo. This work successfully examined the adequacy and viability of the application for this agent in vitro and in vivo. A small animal whole body counter was designed and constructed to allow us to monitor biodistribution and kinetic mechanisms using a radioisotope labeled complex. The procedures of metal labeling, separation and purification have been established from this work. A biodistribution study has been performed using radioisotope induced organ/tissue counting and gamma camera imaging. The ratio of percentage of injected dose per gram organ/tissue for kidney and liver is 3.71 from whole body counter and 3.77 from the gamma camera. The results suggested that retention of Gd (III) is too high and a more kinetically stable chelate should be developed. The pharmacokinetic was evaluated in the whole animal model with the whole body clearance, and a kinetics model was developed. The pharmacokinetic results showed a bi-exponential decay in the animal model with two component excretion constants 1.43e(-5) and 0.0038511, which give half-lives of 3 hours and 33.6 days, respectively. Magnetic resonance imaging of this complex resulted in a 52% contrast enhancement in the rat kidney following the agents' administration in vivo.

SU-F-J-08: Quantitative SPECT Imaging of Ra-223 in a Phantom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yue, J; Hobbs, R; Sgouros, G

Purpose: Ra-223 therapy of prostate cancer bone metastases is being used to treat patients routinely. However, the absorbed dose distribution at the macroscopic and microscopic scales remains elusive, due to the inability to image the small activities injected. Accurate activity quantification through imaging is essential to calculate the absorbed dose in organs and sub-units in radiopharmaceutical therapy, enabling personalized absorbed dose-based treatment planning methodologies and more effective and optimal treatments. Methods: A 22 cm diameter by 20 cm long cylindrical phantom, containing a 3.52 cm diameter sphere, was used. A total of 2.01 MBq of Ra-223 was placed in themore » phantom with 177.6 kBq in the sphere. Images were acquired on a dual-head Siemens Symbia T16 gamma camera using three 20% full-width energy windows and centered at 84, 154, and 269 keV (120 projections, 360° rotation, 45 s per view). We have implemented reconstruction of Ra-223 SPECT projections using OS-EM (up to 20 iterations of 10 subsets) with compensation for attenuation using CT-based attenuation maps, collimator-detector response (CDR) (including septal penetration, scatter and Pb x-ray modeling), and scatter in the patient using the effective source scatter estimation (ESSE) method. The CDR functions and scatter kernels required for ESSE were computed using the SIMIND MC simulation code. All Ra-223 photon emissions as well as gamma rays from the daughters Rn-219 and Bi-211 were modeled. Results: The sensitivity of the camera in the three combined windows was 107.3 cps/MBq. The visual quality of the SPECT images was reasonably good and the activity in the sphere was 27% smaller than the true activity. This underestimation is likely due to partial volume effect. Conclusion: Absolute quantitative Ra-223 SPECT imaging is achievable with careful attention to compensate for image degrading factors and system calibration.« less

Gamma-ray detector guidance of breast cancer therapy

NASA Astrophysics Data System (ADS)

Ravi, Ananth

2009-12-01

Breast cancer is the most common form of cancer in women. Over 75% of breast cancer patients are eligible for breast conserving therapy. Breast conserving therapy involves a lumpectomy to excise the gross tumour, followed by adjuvant radiation therapy to eradicate residual microscopic disease. Recent advances in the understanding of breast cancer biology and recurrence have presented the opportunity to improve breast conserving therapy techniques. This thesis has explored the potential of gamma-ray detecting technology to improve guidance of both surgical and adjuvant radiation therapy aspects of breast conserving therapy. The task of accurately excising the gross tumour during breast conserving surgery (BCS) is challenging, due to the limited guidance currently available to surgeons. Radioimmuno guided surgery (RIGS) has been investigated to determine its potential to delineate the gross tumour intraoperatively. The effects of varying a set of user controllable parameters on the ability of RIGS to detect and delineate model breast tumours was determined. The parameters studied were: Radioisotope, blood activity concentration, collimator height and energy threshold. The most sensitive combination of parameters was determined to be an 111Indium labelled radiopharmaceutical with a gamma-ray detecting probe collimated to a height of 5 mm and an energy threshold at the Compton backscatter peak. Using these parameters it was found that, for the breast tumour model used, the minimum tumour-to-background ratio required to delineate the tumour edge accurately was 5.2+/-0.4 at a blood activity concentration of 5 kBq/ml. Permanent breast seed implantation (PBSI) is a form of accelerated partial breast irradiation that dramatically reduces the treatment burden of adjuvant radiation therapy on patients. Unfortunately, it is currently difficult to localize the implanted brachytherapy seeds, making it difficult to perform a correction in the event that seeds have been misplaced. One method to provide intraoperative seed localization is through the use of a gamma-camera system. Monte Carlo simulations were conducted of a Cadmium Zinc Telluride (CZT) gamma-camera system and a realistic model of a breast with 3 layers of seeds distributed according to the pre-implant treatment plan of a typical patient. The simulations showed that a gamma-camera was able to localize the seeds with a maximum error of 2.0 mm within 20 seconds. An experimental prototype was designed and constructed to validate these promising Monte Carlo results. Using a 64 pixel linear array CZT detector fitted with a custom built brass collimator, images were acquired of a physical phantom similar to the model used in the Monte Carlo simulations. The experimental prototype was able to reliably detect the seeds within 30 seconds with a median error in localization of 1 mm. The results from this thesis suggest that gamma-ray detecting technology may be able to provide significant improvements in guidance of breast cancer therapies and, thus, potentially improved therapeutic outcomes.

Aspherical mirrors for the Gamma-ray Cherenkov Telescope, a Schwarschild-Couder prototype proposed for the future Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Dournaux, J. L.; Gironnet, J.; Huet, J. M.; Laporte, P.; Chadwick, P.; Dumas, D.; Pech, M.; Rulten, C. B.; Sayède, F.; Schmoll, J.; Sol, H.

2016-07-01

The Cherenkov Telescope Array (CTA) project, led by an international collaboration of institutes, aims to create the world's largest next generation Very High-Energy (VHE) gamma-ray telescope array, devoted to observations in a wide band of energy, from a few tens of GeV to more than 100 TeV. The Small-Sized Telescopes (SSTs) are dedicated to the highest energy range. Seventy SSTs are planned in the baseline array design with a required lifetime of about 30 years. The GCT (Gamma-ray Cherenkov Telescope) is one of the prototypes proposed for CTA's SST sub-array. It is based on a Schwarzschild-Couder dual-mirror optical design. This configuration has the benefit of increasing the field-of-view and decreasing the masses of the telescope and of the camera. But, in spite of these many advantages, it was never implemented before in ground-based Cherenkov astronomy because of the aspherical and highly curved shape required for the mirrors. The optical design of the GCT consists of a primary 4 meter diameter mirror, segmented in six aspherical petals, a secondary monolithic 2-meter mirror and a light camera. The reduced number of segments simplifies the alignment of the telescope but complicates the shape of the petals. This, combined with the strong curvature of the secondary mirror, strongly constrains the manufacturing process. The Observatoire de Paris implemented metallic lightweight mirrors for the primary and the secondary mirrors of GCT. This choice was made possible because of the relaxed requirements of optical Cherenkov telescopes compared to optical ones. Measurements on produced mirrors show that these ones can fulfill requirements in shape, PSF and reflectivity, with a clear competition between manufacturing cost and final performance. This paper describes the design of these mirrors in the context of their characteristics and how design optimization was used to produce a lightweight design. The manufacturing process used for the prototype and planned for the large scale production is presented as well as the performance, in terms of geometric and optical properties, of the produced mirrors. The alignment procedure of the mirrors is also detailed. This technique is finally compared to other manufacturing techniques based on composite glass mirrors within the framework of GCT mirrors specificities.

Prototype of microbolometer thermal infrared camera for forest fire detection from space

NASA Astrophysics Data System (ADS)

Guerin, Francois; Dantes, Didier; Bouzou, Nathalie; Chorier, Philippe; Bouchardy, Anne-Marie; Rollin, Joël.

2017-11-01

The contribution of the thermal infrared (TIR) camera to the Earth observation FUEGO mission is to participate; to discriminate the clouds and smoke; to detect the false alarms of forest fires; to monitor the forest fires. Consequently, the camera needs a large dynamic range of detectable radiances. A small volume, low mass and power are required by the small FUEGO payload. These specifications can be attractive for other similar missions.

Subunit association of gamma-glutamyltranspeptidase of Escherichia coli K-12.

PubMed

Hashimoto, W; Suzuki, H; Nohara, S; Tachi, H; Yamamoto, K; Kumagai, H

1995-12-01

gamma-Glutamyltranspeptidase [EC 2.3.2.2] of Escherichia coli K-12 consists of one large subunit and one small subunit, which can be separated from each other by high-performance liquid chromatography. Using ion spray mass spectrometry, the masses of the large and the small subunit were determined to be 39,207 and 20,015, respectively. The large subunit exhibited no gamma-glutamyltranspeptidase activity and the small subunit had little enzymatic activity, but a mixture of the two subunits showed partial recovery of the enzymatic activity. The results of native-polyacrylamide gel electrophoresis suggested that they could partially recombine, and that the recombined dimer exhibited enzymatic activity. The gene of gamma-glutamyltranspeptidase encoded a signal peptide, and the large and small subunits in a single open reading frame in that order. Two kinds of plasmid were constructed encoding the signal peptide and either the large or the small subunit. A gamma-glutamyltranspeptidase-less mutant of E. coli K-12 was transformed with each plasmid or with both of them. The strain harboring the plasmid encoding each subunit produced a small amount of the corresponding subunit protein in the periplasmic space but exhibited no enzymatic activity. The strain transformed with both plasmids together exhibited the enzymatic activity, but its specific activity was approximately 3% of that of a strain harboring a plasmid encoding the intact structural gene. These results indicate that a portion of the separated large and small subunits can be reconstituted in vitro and exhibit the enzymatic activity, and that the expressed large and small subunits independently are able to associate in vivo and be folded into an active structure, though the specific activity of the associated subunits was much lower than that of native enzyme. This suggests that the synthesis of gamma-glutamyltranspeptidase in a single precursor polypeptide and subsequent processing are more effective to construct the intact structure of gamma-glutamyltranspeptidase than the association of the separated large and small subunits.

Micro-satellites (~ 50 kg) for the fundamental and applied science. Capacity building for Russian Academy of Sciences

NASA Astrophysics Data System (ADS)

Zelenyi, Lev; Rodin, V.; Gurevich, A.; Alferov, A.; Getsov, P.

Design and manufacturing of micro-satellite ( 50 kg) platforms for the fundamental and applied research of the Earth and near-earth outer space is a problem which is complex both scientifically and technically. Main point is to define the scientific task which could be effectively solved by micro-satellite instrumentation. It is necessary also to carry out an integral approach in the course of the spacecraft development: find methods to introduce the contemporary technological-design, use the achievements of advanced physical instrument manufacturing , microelectronics and micromechanics. Technical solutions should provide the required accuracy of spacecraft orientation and stabilization. Space Research and Physical Institutes RAS with participation of Moscow University developed the model composition and technical design of micro satellite "CHIBIS" (small bird LAPWING in Russian) with two options for scientific payload: A. The complex of scientific instruments N1 for the monitoring of Global warming and the electromagnetic environment of the Earth: spectrometer for measurements of the total content of greenhouse gases (CO2 and CH4); optical camera (spatial resolution 300 m); lowfrequency flux-gate magnetometer (DC - 64 Hz); high-frequency search-coil magnetometer (0.1 - 40 kHz); analyzer of the electromagnetic emissions (0.1 - 40 kHz); detector of ionospheric plasma. B. The complex of scientific instruments N2 for investigation of fine scale physics of lightning discharges: X-ray - gamma detector (range of X-ray and gamma emission - 50-500 keV); UV detector (range UV - emission - 300-450 nm); radiofrequency analyzer (20 - 50 MHz); optical camera. Spacecraft manufacturing and scientific experiments are prepared mostly by the institutes of Russian academy of sciences without traditional involvement of large scale space industry. So this activity serves as a substantial driver of Academic capacity building for the independent research of space science problems. Further extension of this program is planned now to be within the framework of collaboration between Russian and Bulgarian Academies of Sciences on "BalkanSat" project. Recently ((3/7 -09-2007) special international workshop on the Use of Micro-Satellite Technologies for Environmental Monitoring and Impact to Human Health was held by United Nations, IKI , RAS and ESA in the small city TARUSA near Moscow. Proceedings are available at http://www.iki.rssi.ru/ This work was partially supported of the RFBR grants 06-02-08076 and 06-02-08244

Long-term changes in open field activity of male mice irradiated with low levels of gamma rays at late stage of development.

PubMed

Minamisawa, T; Hirokaga, K

1996-06-01

The open field activity of first generation (F1) hybrid male C57BL/6 x C3H mice irradiated with gamma-rays on the 14th day of gestation was studied at the following ages: 6-7 months, 12-13 months and 19-20 months. Doses were 0.1 Gy or 0.2 Gy. Open field activity was recorded with a camera. The camera output signal was recorded every sec through an A/D converter to a personal computer. The field was divided into 25 units of 8 cm square. All recordings were continuous for 60 min. The time which the 0.2-Gy group recorded at 6-7 months, spent in the 4 squares in the corner fields was high in comparison with the control group at the same age. The walking distance of the 0.1-Gy group recorded at 12-13 months was longer than that for the age matched control group. No effect of radiation was found on any of the behaviors observed and recorded at 19-20 months. The results demonstrate that exposure to low levels of gamma-rays on the 14th day of gestation results in behavioral changes, which occur at 6-7 and 12-13 months but not 19-20 months.

X-ray shout echoing through space

NASA Astrophysics Data System (ADS)

2004-01-01

a flash of X-rays hi-res Size hi-res: 3991 Kb Credits: ESA, S. Vaughan (University of Leicester) EPIC camera shows the expanding rings caused by a flash of X-rays XMM-Newton's X-ray EPIC camera shows the expanding rings caused by a flash of X-rays scattered by dust in our Galaxy. The X-rays were produced by a powerful gamma-ray burst that took place on 3 December 2003. The slowly fading afterglow of the gamma-ray burst is at the centre of the expanding rings. Other, unrelated, X-ray sources can also be seen. The time since the gamma-ray explosion is shown in each panel in hours. At their largest size, the rings would appear in the sky about five times smaller than the full moon. a flash of X-rays hi-res Size hi-res: 2153 Kb Credits: ESA, S. Vaughan (University of Leicester) EPIC camera shows the expanding rings caused by a flash of X-rays (Please choose "hi-res" version for animation) XMM-Newton's X-ray EPIC camera shows the expanding rings caused by a flash of X-rays scattered by dust in our Galaxy. The X-rays were produced by a powerful gamma-ray burst that took place on 3 December 2003. The slowly fading afterglow of the gamma-ray burst is at the centre of the expanding rings. Other, unrelated, X-ray sources can also be seen. The time since the gamma-ray explosion is shown in each panel in seconds. At their largest size, the rings would appear in the sky about five times smaller than the full moon. This echo forms when the powerful radiation of a gamma-ray burst, coming from far away, crosses a slab of dust in our Galaxy and is scattered by it, like the beam of a lighthouse in clouds. Using the expanding rings to precisely pin-point the location of this dust, astronomers can identify places where new stars and planets are likely to form. On 3 December 2003 ESA's observatory, Integral, detected a burst of gamma rays, lasting about 30 seconds, from the direction of a distant galaxy. Within minutes of the detection, thanks to a sophisticated alert network, many observatories around the world were pointing their instruments at this mysterious source in the sky, named GRB 031203, in the attempt to decipher its nature. Also ESA's X-ray observatory, XMM-Newton, joined the hunt and observed the source in detail, using its on-board European Photon Imaging Camera (EPIC). The fading X-ray emission from GRB 031203 - called the `afterglow' - is clearly seen in XMM-Newton's images. But much more stunning are the two rings, centred on the afterglow, which appear to expand thousand times faster than the speed of light. Dr. Simon Vaughan, of the University of Leicester, United Kingdom, leads an international team of scientists studying GRB 031203. He explains that these rings are what astronomers call an `echo'. They form when the X-rays from the distant gamma-ray burst shine on a layer of dust in our own Galaxy. "The dust scatters some of the X-rays, causing XMM-Newton to observe these rings, much in the same way as fog scatters the light from a car's headlights," said Vaughan. Although the afterglow is the brightest feature seen in XMM-Newton's images, the expanding echo is much more spectacular. "It is like a shout in a cathedral," Vaughan said. "The shout of the gamma-ray burst is louder, but the Galactic reverberation, seen as the rings, is much more beautiful." The rings seem to expand because the X-rays scattered by dust farther from the direction of GRB 031203 take longer to reach us than those hitting the dust closer to the line of sight. However, nothing can move faster than light. "This is precisely what we expect because of the finite speed of light," said Vaughan. "The rate of expansion that we see is just a visual effect." He and his colleagues explain that we see two rings because there are two thin sheets of dust between the source of the gamma-ray burst and Earth, one closer to us creating the wider ring and one further away where the smaller ring is formed. Since they know precisely at what speed the X-ray light travels in space, the team in Leicester have determined accurately the distance to the dust sheets by measuring the size of the expanding rings. The nearest dust sheet is located 2900 light years away and is probably part of the Gum nebula, a bubble of hot gas resulting from many supernova explosions. The other dust layer is about 4500 light years away. Understanding how dust is distributed in our Galaxy is important because dust favours the collapse of cool gas clouds, which can then form stars and planets. Knowing where dust is located helps astronomers to determine where star and planet formation is likely to occur. Expanding X-ray dust scattering rings, such as those around GRB 031203, have never been seen before. Slower-moving rings, caused by a similar effect, have been seen in visible light around a very few exploding stars, mostly supernovae. The expanding rings also provide much needed information on the gamma-ray burst itself. Gamma-ray bursts are the most powerful explosive events in the Universe, but astronomers are still trying to understand the mystery that surrounds their origin. Some occur with the supernova explosion of a massive star when it has used up all of its fuel, although only stars which have lost their outer layers and which collapse to make a black hole seem able to make a gamma-ray burst. The delayed X-rays from the echo of GRB 031203 are very useful because they tell astronomers how bright the burst was in the X-ray spectrum when it went off on 3 December. The only direct data available from that moment are those obtained by ESA's Integral observatory in the gamma-ray range. "XMM-Newton's measurements are thus crucial to better understand the nature of the burst," said Dr. Fred Jansen, XMM-Newton's project scientist. "The more details we gather of the burst, the more we can learn on how black holes are made." Today, ESA's Integral and XMM-Newton observatories provide astronomers with their most powerful facilities for studying gamma-ray bursts. In 2004 a new gamma-ray satellite, called `Swift', will be launched as part of a collaboration between the USA, United Kingdom and Italy. Swift will add to the flotilla of satellites providing fast and accurate locations of gamma-ray bursts on the sky, which can then be followed with XMM-Newton. This will provide even more opportunities for new discoveries in this cutting-edge field. Notes to editors A scientific paper describing this discovery by Dr. Simon Vaughan and his collaborators has been accepted for publication in ``The Astrophysical Journal'' (see http://arxiv.org/abs/astro-ph/0312603). The other members in Vaughan's team are R. Willingale, P. O'Brien, J. Osborne, A. Levan, M. Watson and J. Tedds from the University of Leicester, United Kingdom; J. Reeves from NASA's Goddard Space Flight Center in Greenbelt, USA; D. Watson from the Neils Bohr Institute for Astronomy in Copenhagen, Denmark; M. Santos-Lleo, P. Rodriguez-Pascual and N. Schartel from ESA's XMM-Newton Science Operations Centre in Villafranca, Spain. Figure caption XMM-Newton's X-ray EPIC camera shows the expanding rings caused by a flash of X-rays scattered by dust in our Galaxy. The X-rays were produced by a powerful gamma-ray burst that took place on 3 December 2003. The slowly fading afterglow of the gamma-ray burst is at the centre of the expanding rings. Other, unrelated, X-ray sources can also be seen. The time since the gamma-ray explosion is shown in each panel in hours. At their largest size, the rings would appear in the sky about five times smaller than the full moon. Credit: ESA, S. Vaughan (University of Leicester) Video caption XMM-Newton's X-ray EPIC camera shows the expanding rings caused by a flash of X-rays scattered by dust in our Galaxy. The X-rays were produced by a powerful gamma-ray burst that took place on 3 December 2003. The slowly fading afterglow of the gamma-ray burst is at the centre of the expanding rings. Other, unrelated, X-ray sources can also be seen. The time since the gamma-ray explosion is shown in each panel in seconds. At their largest size, the rings would appear in the sky about five times smaller than the full moon. Credit: ESA, S. Vaughan (University of Leicester) More about XMM-Newton XMM-Newton can detect more X-ray sources than any previous satellite and is helping to solve many cosmic mysteries of the violent Universe, from black holes to the formation of galaxies. It was launched on 10 December 1999, using an Ariane-5 rocket from French Guiana. It is expected to return data for a decade. XMM-Newton's high-tech design uses over 170 wafer-thin cylindrical mirrors spread over three telescopes. Its orbit takes it almost a third of the way to the Moon, so that astronomers can enjoy long, uninterrupted views of celestial objects.

View of Scientific Instrument Module to be flown on Apollo 15

NASA Image and Video Library

1971-06-27

S71-2250X (June 1971) --- A close-up view of the Scientific Instrument Module (SIM) to be flown for the first time on the Apollo 15 lunar landing mission. Mounted in a previously vacant sector of the Apollo Service Module (SM), the SIM carries specialized cameras and instrumentation for gathering lunar orbit scientific data. SIM equipment includes a laser altimeter for accurate measurement of height above the lunar surface; a large-format panoramic camera for mapping, correlated with a metric camera and the laser altimeter for surface mapping; a gamma ray spectrometer on a 25-feet extendible boom; a mass spectrometer on a 21-feet extendible boom; X-ray and alpha particle spectrometers; and a subsatellite which will be injected into lunar orbit carrying a particle and magnetometer, and the S-Band transponder.

A gamma beam profile imager for ELI-NP Gamma Beam System

NASA Astrophysics Data System (ADS)

Cardarelli, P.; Paternò, G.; Di Domenico, G.; Consoli, E.; Marziani, M.; Andreotti, M.; Evangelisti, F.; Squerzanti, S.; Gambaccini, M.; Albergo, S.; Cappello, G.; Tricomi, A.; Veltri, M.; Adriani, O.; Borgheresi, R.; Graziani, G.; Passaleva, G.; Serban, A.; Starodubtsev, O.; Variola, A.; Palumbo, L.

2018-06-01

The Gamma Beam System of ELI-Nuclear Physics is a high brilliance monochromatic gamma source based on the inverse Compton interaction between an intense high power laser and a bright electron beam with tunable energy. The source, currently being assembled in Magurele (Romania), is designed to provide a beam with tunable average energy ranging from 0.2 to 19.5 MeV, rms energy bandwidth down to 0.5% and flux of about 108 photons/s. The system includes a set of detectors for the diagnostic and complete characterization of the gamma beam. To evaluate the spatial distribution of the beam a gamma beam profile imager is required. For this purpose, a detector based on a scintillator target coupled to a CCD camera was designed and a prototype was tested at INFN-Ferrara laboratories. A set of analytical calculations and Monte Carlo simulations were carried out to optimize the imager design and evaluate the performance expected with ELI-NP gamma beam. In this work the design of the imager is described in detail, as well as the simulation tools used and the results obtained. The simulation parameters were tuned and cross-checked with the experimental measurements carried out on the assembled prototype using the beam from an x-ray tube.

VERITAS: status c.2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weekes, T. C.; Atkins, R. W.; Badran, H. M.

2006-07-11

VERITAS (Very Energetic Radiation Imaging Telescope Array System), is one of a new generation of TeV gamma-ray observatories. The current status of its construction is described here. The first two telescopes and cameras have been completed and meet the design specifications; the full array of four telescopes could be operational by the end of 2006.

Phantom feet on digital radionuclide images and other scary computer tales

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freitas, J.E.; Dworkin, H.J.; Dees, S.M.

1989-09-01

Malfunction of a computer-assisted digital gamma camera is reported. Despite what appeared to be adequate acceptance testing, an error in the system gave rise to switching of images and identification text. A suggestion is made for using a hot marker, which would avoid the potential error of misinterpretation of patient images.

An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras.

PubMed

Bolotnikov, A E; Ackley, K; Camarda, G S; Cherches, C; Cui, Y; De Geronimo, G; Fried, J; Hodges, D; Hossain, A; Lee, W; Mahler, G; Maritato, M; Petryk, M; Roy, U; Salwen, C; Vernon, E; Yang, G; James, R B

2015-07-01

We developed a robust and low-cost array of virtual Frisch-grid CdZnTe detectors coupled to a front-end readout application-specific integrated circuit (ASIC) for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6 × 6 × 15 mm(3) detectors grouped into 3 × 3 sub-arrays of 2 × 2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays' performance and reduction of their cost are possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects.

Absorbed radiation dose in adults from iodine-131 and iodine-123 orthoiodohippurate and technetium-99m DTPA renography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlsen, O.

1988-03-01

A mathematic model for evaluation of absorbed dose in radionuclide renography has been developed and programmed for automatic calculation in the computer. Input data to the model are readily available from the results of the renography and, hence, the method described is suitable for individual dose determinations in adults. Apart from the situation with very considerable outflow obstructions (/sup 131/I)OIH single probe renography involves a 15-20 times smaller dose to radiation sensitive organs than (/sup 123/I)OIH gamma camera renography. Further, the latter examination results in a 2-10 times smaller dose than (/sup 99m/Tc)DTPA gamma camera renography under normal outflow conditions.more » Absorbed renal dose is large, approximately 70 mGy, in the three renographies in the borderline case with total outflow obstructions. For comparison, i.v. pyelography, which is the x-ray examination often used instead of radionuclide renography, involves an absorbed dose to ovaries 10-1000 times larger than in radionuclide renography« less

An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras

DOE PAGES

Bolotnikov, A. E.; Ackley, K.; Camarda, G. S.; ...

2015-07-28

We developed a robust and low-cost array of virtual Frisch-grid CdZnTe (CZT) detectors coupled to a front-end readout ASIC for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6x6x15 mm 3 detectors grouped into 3x3 sub-arrays of 2x2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readoutmore » electronics. The further enhancement of the arrays’ performance and reduction of their cost are made possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects.« less

Metabolic cardiac imaging in severe coronary disease: assessment of viability with iodine-123-iodophenylpentadecanoic acid and multicrystal gamma camera, and correlation with biopsy.

PubMed

Murray, G; Schad, N; Ladd, W; Allie, D; vander Zwagg, R; Avet, P; Rockett, J

1992-07-01

Fifteen patients with coronary disease and resting left ventricular ejection fractions of less than or equal to 0.35 underwent resting metabolic cardiac imaging utilizing 1 mCi [123I]iodophenylpentadecanoic acid (IPPA) intravenously and a multicrystal gamma camera. Parametric images of regional rates of IPPA clearance and accumulation were generated. Forty-two vascular territories (22 infarcted) were evaluated by metabolic imaging as well as transmural myocardial biopsy. Despite resting akinesis or dyskinesis in 20/22 (91%) infarcted territories, 16/22 (73%) of these territories were metabolically viable. Transmural myocardial biopsies in all patients (43 sites, 42 vascular territories) during coronary bypass surgery confirmed IPPA results in 39/43 patients (91%). When compared to biopsy, scan sensitivity for viability was 33/36 (92%) with a specificity of 6/7 (86%). Eighty percent of bypassed, infarcted but IPPA viable segments demonstrated improved regional systolic wall motion postoperatively as assessed by exercise radionuclide angiography. We conclude resting IPPA imaging identifies viable myocardium, thereby providing a safe, cost-effective technique for myocardial viability assessment.

Miniature Wide-Angle Lens for Small-Pixel Electronic Camera

NASA Technical Reports Server (NTRS)

Mouroulils, Pantazis; Blazejewski, Edward

2009-01-01

A proposed wideangle lens is shown that would be especially well suited for an electronic camera in which the focal plane is occupied by an image sensor that has small pixels. The design of the lens is intended to satisfy requirements for compactness, high image quality, and reasonably low cost, while addressing issues peculiar to the operation of small-pixel image sensors. Hence, this design is expected to enable the development of a new generation of compact, high-performance electronic cameras. The lens example shown has a 60 degree field of view and a relative aperture (f-number) of 3.2. The main issues affecting the design are also shown.

Low, slow, small target recognition based on spatial vision network

NASA Astrophysics Data System (ADS)

Cheng, Zhao; Guo, Pei; Qi, Xin

2018-03-01

Traditional photoelectric monitoring is monitored using a large number of identical cameras. In order to ensure the full coverage of the monitoring area, this monitoring method uses more cameras, which leads to more monitoring and repetition areas, and higher costs, resulting in more waste. In order to reduce the monitoring cost and solve the difficult problem of finding, identifying and tracking a low altitude, slow speed and small target, this paper presents spatial vision network for low-slow-small targets recognition. Based on camera imaging principle and monitoring model, spatial vision network is modeled and optimized. Simulation experiment results demonstrate that the proposed method has good performance.

Multimodal US-gamma imaging using collaborative robotics for cancer staging biopsies.

PubMed

Esposito, Marco; Busam, Benjamin; Hennersperger, Christoph; Rackerseder, Julia; Navab, Nassir; Frisch, Benjamin

2016-09-01

The staging of female breast cancer requires detailed information about the level of cancer spread through the lymphatic system. Common practice to obtain this information for patients with early-stage cancer is sentinel lymph node (SLN) biopsy, where LNs are radioactively identified for surgical removal and subsequent histological analysis. Punch needle biopsy is a less invasive approach but suffers from the lack of combined anatomical and nuclear information. We present and evaluate a system that introduces live collaborative robotic 2D gamma imaging in addition to live 2D ultrasound to identify SLNs in the surrounding anatomy. The system consists of a robotic arm equipped with both a gamma camera and a stereoscopic tracking system that monitors the position of an ultrasound probe operated by the physician. The arm cooperatively places the gamma camera parallel to the ultrasound imaging plane to provide live multimodal visualization and guidance. We validate the system by evaluating the target registration errors between fused nuclear and US image data in a phantom consisting of two spheres, one of which is filled with radioactivity. Medical experts perform punch biopsies on agar-gelatine phantoms with complex configurations of hot and cold lesions to provide a qualitative and quantitative evaluation of the system. The average point registration error for the overlay is [Formula: see text] mm. The time of the entire procedure was reduced by 36 %, with 80v of the biopsies being successful. The users' feedback was very positive, and the system was deemed to be very intuitive, with handling similar to classic US-guided needle biopsy. We present and evaluate the first medical collaborative robotic imaging system. Feedback from potential users for SLN punch needle biopsy is encouraging. Ongoing work investigates the clinical feasibility with more complex and realistic phantoms.

Imaging Polarimeter for a Sub-MeV Gamma-Ray All-sky Survey Using an Electron-tracking Compton Camera

DOE Office of Scientific and Technical Information (OSTI.GOV)

Komura, S.; Takada, A.; Mizumura, Y.

2017-04-10

X-ray and gamma-ray polarimetry is a promising tool to study the geometry and the magnetic configuration of various celestial objects, such as binary black holes or gamma-ray bursts (GRBs). However, statistically significant polarizations have been detected in few of the brightest objects. Even though future polarimeters using X-ray telescopes are expected to observe weak persistent sources, there are no effective approaches to survey transient and serendipitous sources with a wide field of view (FoV). Here we present an electron-tracking Compton camera (ETCC) as a highly sensitive gamma-ray imaging polarimeter. The ETCC provides powerful background rejection and a high modulation factormore » over an FoV of up to 2 π sr thanks to its excellent imaging based on a well-defined point-spread function. Importantly, we demonstrated for the first time the stability of the modulation factor under realistic conditions of off-axis incidence and huge backgrounds using the SPring-8 polarized X-ray beam. The measured modulation factor of the ETCC was 0.65 ± 0.01 at 150 keV for an off-axis incidence with an oblique angle of 30° and was not degraded compared to the 0.58 ± 0.02 at 130 keV for on-axis incidence. These measured results are consistent with the simulation results. Consequently, we found that the satellite-ETCC proposed in Tanimori et al. would provide all-sky surveys of weak persistent sources of 13 mCrab with 10% polarization for a 10{sup 7} s exposure and over 20 GRBs down to a 6 × 10{sup −6} erg cm{sup −2} fluence and 10% polarization during a one-year observation.« less

Ambient Dose Equivalent measured at the Instituto Nacional de Cancerologia Department of Nuclear Medicine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Avila, O.; Torres-Ulloa, C. L.; Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, AP 70-542, 04510, DF

2010-12-07

Ambient dose equivalent values were determined in several sites at the Instituto Nacional de Cancerologia, Departmento de Medicina Nuclear, using TLD-100 and TLD-900 thermoluminescent dosemeters. Additionally, ambient dose equivalent was measured at a corridor outside the hospitalization room for patients treated with {sup 137}Cs brachytherapy. Dosemeter calibration was performed at the Instituto Nacional de Investigaciones Nucleares, Laboratorio de Metrologia, to known {sup 137}Cs gamma radiation air kerma. Radionuclides considered for this study are {sup 131}I, {sup 18}F, {sup 67}Ga, {sup 99m}Tc, {sup 111}In, {sup 201}Tl and {sup 137}Cs, with main gamma energies between 93 and 662 keV. Dosemeters were placedmore » during a five month period in the nuclear medicine rooms (containing gamma-cameras), injection corridor, patient waiting areas, PET/CT study room, hot lab, waste storage room and corridors next to the hospitalization rooms for patients treated with {sup 131}I and {sup 137}Cs. High dose values were found at the waste storage room, outside corridor of {sup 137}Cs brachytherapy patients and PET/CT area. Ambient dose equivalent rate obtained for the {sup 137}Cs brachytherapy corridor is equal to (18.51{+-}0.02)x10{sup -3} mSv/h. Sites with minimum doses are the gamma camera rooms, having ambient dose equivalent rates equal to (0.05{+-}0.03)x10{sup -3} mSv/h. Recommendations have been given to the Department authorities so that further actions are taken to reduce doses at high dose sites in order to comply with the ALARA principle (as low as reasonably achievable).« less

Imaging Polarimeter for a Sub-MeV Gamma-Ray All-sky Survey Using an Electron-tracking Compton Camera

NASA Astrophysics Data System (ADS)

Komura, S.; Takada, A.; Mizumura, Y.; Miyamoto, S.; Takemura, T.; Kishimoto, T.; Kubo, H.; Kurosawa, S.; Matsuoka, Y.; Miuchi, K.; Mizumoto, T.; Nakamasu, Y.; Nakamura, K.; Oda, M.; Parker, J. D.; Sawano, T.; Sonoda, S.; Tanimori, T.; Tomono, D.; Yoshikawa, K.

2017-04-01

X-ray and gamma-ray polarimetry is a promising tool to study the geometry and the magnetic configuration of various celestial objects, such as binary black holes or gamma-ray bursts (GRBs). However, statistically significant polarizations have been detected in few of the brightest objects. Even though future polarimeters using X-ray telescopes are expected to observe weak persistent sources, there are no effective approaches to survey transient and serendipitous sources with a wide field of view (FoV). Here we present an electron-tracking Compton camera (ETCC) as a highly sensitive gamma-ray imaging polarimeter. The ETCC provides powerful background rejection and a high modulation factor over an FoV of up to 2π sr thanks to its excellent imaging based on a well-defined point-spread function. Importantly, we demonstrated for the first time the stability of the modulation factor under realistic conditions of off-axis incidence and huge backgrounds using the SPring-8 polarized X-ray beam. The measured modulation factor of the ETCC was 0.65 ± 0.01 at 150 keV for an off-axis incidence with an oblique angle of 30° and was not degraded compared to the 0.58 ± 0.02 at 130 keV for on-axis incidence. These measured results are consistent with the simulation results. Consequently, we found that the satellite-ETCC proposed in Tanimori et al. would provide all-sky surveys of weak persistent sources of 13 mCrab with 10% polarization for a 107 s exposure and over 20 GRBs down to a 6 × 10-6 erg cm-2 fluence and 10% polarization during a one-year observation.

PBF (PER620) north facade. Camera facing south. Small metal shed ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PBF (PER-620) north facade. Camera facing south. Small metal shed at right is Stack Gas Monitor Building, PER-629. Date: March 2004. INEEL negative no. HD-41-2-4 - Idaho National Engineering Laboratory, SPERT-I & Power Burst Facility Area, Scoville, Butte County, ID

SYNTHESIS OF ALPHA-AMINO GAMMA-LACTONE VIA A NOVEL TANDEM THREE-COMPONENT REACTION OF ALKENES, GLYOXYLATES AND AMINES. (R822668)

EPA Science Inventory

Abstract

-Amino -lactones were generated by an InCl₃...

Single photon emission tomography in neurological studies: Instrumentation and clinical applications

NASA Astrophysics Data System (ADS)

Nikkinen, Paivi Helena

One triple head and two single head gamma camera systems were used for single photon emission tomography (SPET) imaging of both patients and brain phantoms. Studies with an anatomical brain phantom were performed for evaluation of reconstruction and correction methods in brain perfusion SPET studies. The use of the triple head gamma camera system resulted in a significant increase in image contrast and resolution. This was mainly due to better imaging geometry and the use of a high resolution collimator. The conventional Chang attenuation correction was found suitable for the brain perfusion studies. In the brain perfusion studies region of interest (ROI) based semiquantitation methods were used. A ROI map based on anatomical areas was used in 70 elderly persons (age range 55-85 years) without neurological diseases and in patients suffering from encephalitis or having had a cardiac arrest. Semiquantitative reference values are presented. For the 14 patients with encephalitis the right-to-left side differences were calculated. Defect volume indexes were calculated for 64 patients with brain infarcts. For the 30 cardiac arrest patients the defect percentages and the anteroposterior ratios were used for semiquantitation. It is concluded that different semiquantitation methods are needed for the various patient groups. Age-related reference values will improve the interpretation of SPET data. For validation of the basal ganglia receptor studies measurements were performed using a cylindrical and an anatomical striatal phantom. In these measurements conventional and transmission imaging based non-uniform attenuation corrections were compared. A calibration curve was calculated for the determination of the specific receptor uptake ratio. In the phantom studies using the triple head camera the uptake ratio obtained from simultaneous transmission-emission protocol (STEP) acquisition and iterative reconstruction was closest to the true activity ratio. Conventional acquisition and uniform Chang attenuation correction gave 40% lower values. The effect of dual window scatter correction was also measured. In conventional reconstruction dual window scatter correction increased the uptake ratios when using a single head camera, but when using the triple head camera this correction did not have a significant effect on the ratios. Semiquantitative values for striatal 123I-labelled β-carbomethoxy-3β- (4-iodophenyl)tropane (123I-βCIT) dopamine transporter uptake in 20 adults (mean age 52 +/- 15 years) are presented. The mean basal ganglia to cerebellum ratio was 6.5 +/- 0.9 and the mean caudatus to putamen ratio was 1.2. The registration of brain SPET and magnetic resonance (MR) studies provides the necessary anatomical information for determination of the ROIs. A procedure for registration and simultaneous display of brain SPET and MR images based on six external skin markers is presented. The usefulness of this method was demonstrated in selected patients. The registration accuracy was determined for single and triple head gamma camera systems using brain phantom and simulation studies. The registration residual for three internal test markers was calculated using 4 to 13 external markers in the registration. For 6 external markers, as used in the registration in the patient studies, the mean RMS residuals of the test markers for the single head camera and the triple head camera were 3.5 mm and 3.2 mm, respectively. According to the simulation studies the largest inaccuracy is due mainly to the spatial resolution of SPET. The use of six markers, as in the patient studies, is adequate for accurate registration.

X-ray emission from high temperature plasmas

NASA Technical Reports Server (NTRS)

Harries, W. L.

1974-01-01

X-rays from a 25-hJ plasma focus apparatus were observed with pinhole cameras. The cameras consist of 0.4 mm diameter pinholes in 2 cm thick lead housing enclosing an X-ray intensifying screen at the image plane. Pictures recorded through thin aluminum foils or plastic sheets for X-ray energies sub gamma smaller than 15 keV show distributed X-ray emissions from the focussed plasma and from the anode surface. However, when thick absorbers are used, radial filamentary structure in the X-ray emission from the anode surface is revealed. Occasionally larger structures are observed in addition to the filaments. Possible mechanisms for the filamentary structure are discussed.

Using a smart phone application to measure high-energy radiation from thunderstorms

NASA Astrophysics Data System (ADS)

Bowers, G. S.; Smith, D. M.; Rexroad, W. Z.; Kelley, N. A.; Martinez-Mckinney, F.; Rubenstein, E. P.; Drukier, G.; Benes, G. N.

2013-12-01

Commercial airline flights and developing cell phone technologies present a burgeoning opportunity for the public to help investigate radiation from thunderstorms, including terrestrial gamma-ray flashes (TGFs), longer-lived gamma-ray glows, x-rays from lightning stepped leaders, and possible high-energy radiation, never yet observed, from blue jets, gigantic jets, and blue starters. GammaPix is a smartphone application from Image Insight, Inc. that uses the camera's CCD or CMOS sensor to identify and qualitatively assess threats related to gamma radioactivity, e.g., those caused by accidental exposure to radioactive material, high-altitude air travel, or acts of terrorism. A science-oriented version of the app is under development that will be publicized for use aboard commercial airline flights and on the ground in regions (like Japan in the wintertime) where thunderstorm charge centers come close to the ground. The primary goal of the project is to learn whether TGFs close to passenger aircraft and population centers on the ground occur often enough to create concern about radiation risk.

Current research on ARO-positron emission tomography

NASA Astrophysics Data System (ADS)

Jan, Meei-Ling; Liang, Hsing C.; Huang, Shin W.; Shyu, Chuen-Shing; Tang, Jiy-Shan; Liu, Hong-Chih; Pei, Cheng-Chih; Yeh, Ching-Kai

2000-06-01

We are presently constructing `AROPET', a rotating PET scanner for imaging small animals. The design of the system has flexible geometry, using four detectors. Each detector is made of a position-sensitive PMTs (Hamamatsu R3941) coupled with 18 X 16 small individual BGO scintillator crystals of dimension 2.6 X 2.6 X 25 mm3. Animals can be imaged in two modes. One is similar to a gamma camera in which the detectors are stationary and a 2D planar projection imaging is obtained. This mode is used for initial characterization of the bio-distribution of tracers. In the other mode the detectors are rotated through 90 degree(s), and the diameter can be adjusted between 22 cm - 40 cm. This mode resembles a conventional 3D PET scan using a partial detector ring. Thirty-one tomographic images can be obtained after rebinning and reconstruction. The field of view is 51.3 mm (transaxial) by 45.6 mm (axial). The spatial resolution of the planar projection mode, and the results of the planar image of a phantom and the dynamical images of the bio-distribution of F18-FDG in a mouse are discussed.

Wireless Synchronization of a Multi-Pinhole Small Animal SPECT Collimation Device With a Clinical Scanner

NASA Astrophysics Data System (ADS)

DiFilippo, Frank P.; Patel, Sagar

2009-06-01

A multi-pinhole collimation device for small animal single photon emission computed tomography (SPECT) uses the gamma camera detectors of a standard clinical SPECT scanner. The collimator and animal bed move independently of the detectors, and therefore their motions must be synchronized. One approach is manual triggering of the SPECT acquisition simultaneously with a programmed motion sequence for the device. However, some data blurring and loss of image quality result, and true electronic synchronization is preferred. An off-the-shelf digital gyroscope with integrated Bluetooth interface provides a wireless solution to device synchronization. The sensor attaches to the SPECT gantry and reports its rotational speed to a notebook computer controlling the device. Software processes the rotation data in real-time, averaging the signal and issuing triggers while compensating for baseline drift. Motion commands are sent to the collimation device with minimal delay, within approximately 0.5 second of the start of SPECT gantry rotation. Test scans of a point source demonstrate an increase in true counts and a reduction in background counts compared to manual synchronization. The wireless rotation sensor provides robust synchronization of the collimation device with the clinical SPECT scanner and enhances image quality.

Low Statistics Reconstruction of the Compton Camera Point Spread Function in 3D Prompt-γ Imaging of Ion Beam Therapy

NASA Astrophysics Data System (ADS)

Lojacono, Xavier; Richard, Marie-Hélène; Ley, Jean-Luc; Testa, Etienne; Ray, Cédric; Freud, Nicolas; Létang, Jean Michel; Dauvergne, Denis; Maxim, Voichiţa; Prost, Rémy

2013-10-01

The Compton camera is a relevant imaging device for the detection of prompt photons produced by nuclear fragmentation in hadrontherapy. It may allow an improvement in detection efficiency compared to a standard gamma-camera but requires more sophisticated image reconstruction techniques. In this work, we simulate low statistics acquisitions from a point source having a broad energy spectrum compatible with hadrontherapy. We then reconstruct the image of the source with a recently developed filtered backprojection algorithm, a line-cone approach and an iterative List Mode Maximum Likelihood Expectation Maximization algorithm. Simulated data come from a Compton camera prototype designed for hadrontherapy online monitoring. Results indicate that the achievable resolution in directions parallel to the detector, that may include the beam direction, is compatible with the quality control requirements. With the prototype under study, the reconstructed image is elongated in the direction orthogonal to the detector. However this direction is of less interest in hadrontherapy where the first requirement is to determine the penetration depth of the beam in the patient. Additionally, the resolution may be recovered using a second camera.

Elemental abundances of the B and A stars. 2: Gamma Geminorum, HD 60825, 7 Sextantis, HR 4817, and HR 5780

NASA Technical Reports Server (NTRS)

Adelman, Saul J.; Philip, A. G. Davis

1994-01-01

We extend fine analyses of the B and A stars, gamma Geminorum, 7 Sextantis, HR 4817, and HR 5780 using additional spectroscopic data from the Kitt Peak National Observatory (KPNO) coude feed telescope with a TI CCD, camera 5, and grating A, and ATLAS9 model atmospheres. In addition we study HD 60825, which had colors similar to the FHB A stars, but was found to be a Population I star. HD 60825, as is gamma Gem, is a sharp-lined early-A star with nearly solar derived abundances. HR 5780 and 7 Sex are also examples of stars which for the most part have solar abundances. The newly derived abundances for HR 4817 reveal important differences with respect to 53 Tau, a somewhat similar HgMn star.

Repeated irradiations with gamma-rays at a Dose of 0.5 Gy may exacerbate asthma.

PubMed

Fang, Su-ping; Tago, Fumitoshi; Tanaka, Takashi; Simura, Noriko; Muto, Yasuko; Goto, Resuke; Kojima, Shuji

2005-06-01

We previously showed that 0.5 Gy whole-body gamma-ray irradiation with a single or small number of repeated exposures inhibits tumor growth in mice, via elevation of the IFN-gamma/IL-4 ratio concomitantly with a decrease in the percentage of B cells. Here we examined whether repeated 0.5 Gy gamma-rays irradiation can improve asthma in an OVA-induced asthmatic mouse model. We found that repeated irradiation (10 times) with 0.5 Gy of gamma-rays significantly increased total IgE in comparison with the disease-control group. The levels of IL-4 and IL-5 were also significantly higher in the gamma-ray-irradiated group, while that of IFN-gamma was significantly lower, resulting in a further decrease of the IFN-gamma/IL-4 ratio from the normal value. These results indicate that the repeated irradiation with gamma-rays may exacerbate asthma, and may have opposite effects on different immune reactions unlike the irradiation with a single or small number of repeated exposures.

Evaluation of the applicability of the SeHCAT test in the investigation of patients with diarrhoea.

PubMed

Orholm, M; Pedersen, J O; Arnfred, T; Rødbro, P; Thaysen, E H

1988-01-01

For the assessment of ileal bile acid conservation the retention of orally administered 75Se-23-selena-25-homotaurocholic acid (SeHCAT), a gamma-ray-emitting radioisotope-labelled synthetic bile acid, was measured by an uncollimated abdominal gamma camera in 89 patients with various gastrointestinal disorders and in 20 persons without gastrointestinal complaints. A significant differences in retention was observed between patients with and without previously detected ileal disease. However, it was not possible by use of the test to differentiate between the various types of diarrhoea. Hence the test is not recommended in the routine investigation of patients with diarrhoea.

Fabricating High-Resolution X-Ray Collimators

NASA Technical Reports Server (NTRS)

Appleby, Michael; Atkinson, James E.; Fraser, Iain; Klinger, Jill

2008-01-01

A process and method for fabricating multi-grid, high-resolution rotating modulation collimators for arcsecond and sub-arcsecond x-ray and gamma-ray imaging involves photochemical machining and precision stack lamination. The special fixturing and etching techniques that have been developed are used for the fabrication of multiple high-resolution grids on a single array substrate. This technology has application in solar and astrophysics and in a number of medical imaging applications including mammography, computed tomography (CT), single photon emission computed tomography (SPECT), and gamma cameras used in nuclear medicine. This collimator improvement can also be used in non-destructive testing, hydrodynamic weapons testing, and microbeam radiation therapy.

Collimator-free photon tomography

DOEpatents

Dilmanian, F. Avraham; Barbour, Randall L.

1998-10-06

A method of uncollimated single photon emission computed tomography includes administering a radioisotope to a patient for producing gamma ray photons from a source inside the patient. Emissivity of the photons is measured externally of the patient with an uncollimated gamma camera at a plurality of measurement positions surrounding the patient for obtaining corresponding energy spectrums thereat. Photon emissivity at the plurality of measurement positions is predicted using an initial prediction of an image of the source. The predicted and measured photon emissivities are compared to obtain differences therebetween. Prediction and comparison is iterated by updating the image prediction until the differences are below a threshold for obtaining a final prediction of the source image.

Lessons Learned in the Development of Gamma-Rover (GRover) Inspection Device

DOE Office of Scientific and Technical Information (OSTI.GOV)

Valdez, Patrick LJ; Alzheimer, James M.; Catalan, Michael A.

2006-02-11

The Gamma-Rover (GRover) is an electrically powered crawler designed to visually inspect and characterize the radiological conditions within the B-Cell and D-Cell ventilation ducting in support of the Hanford Site’s 324 Building Stabilization/Deactivation Project. Due to the bid opening of the Department of Energy’s River Corridor Project prior to deployment, GRover has not yet been deployed. The delay in deployment has allowed the designers to develop lessons learned from the original development in order to propose improvements when the system is deployed in the future. Gamma field information is detected with a pair of Eberline DA1-8/RMS systems. One system ismore » mounted directly on the crawler, while the second is mounted on the deployment platform. Four web cameras on a pair of CAT-5e/USB channels provide video feedback from both the crawler and the deployment platform. The drive system was designed to overcome a potentially difficult path of the duct, which included three ninety-degree bends. Mockups of the duct bends yielded high friction on the tether, and a drive system to overcome this friction was especially difficult to design into such a small package. Deployment was to be performed during a routine air filter change-out. As such, a specialized deployment platform was designed to pass through the existing filter housing. GRover would be required to be staged within the hot cell prior to the filter change-out and could therefore be dosed in excess of 8 hours. Thus, the platform also had to protect the electronics from radiation damage for an extended period of time.« less

Development of a Compton camera for prompt-gamma medical imaging

NASA Astrophysics Data System (ADS)

Aldawood, S.; Thirolf, P. G.; Miani, A.; Böhmer, M.; Dedes, G.; Gernhäuser, R.; Lang, C.; Liprandi, S.; Maier, L.; Marinšek, T.; Mayerhofer, M.; Schaart, D. R.; Lozano, I. Valencia; Parodi, K.

2017-11-01

A Compton camera-based detector system for photon detection from nuclear reactions induced by proton (or heavier ion) beams is under development at LMU Munich, targeting the online range verification of the particle beam in hadron therapy via prompt-gamma imaging. The detector is designed to be capable to reconstruct the photon source origin not only from the Compton scattering kinematics of the primary photon, but also to allow for tracking of the secondary Compton-scattered electrons, thus enabling a γ-source reconstruction also from incompletely absorbed photon events. The Compton camera consists of a monolithic LaBr3:Ce scintillation crystal, read out by a multi-anode PMT acting as absorber, preceded by a stacked array of 6 double-sided silicon strip detectors as scatterers. The detector components have been characterized both under offline and online conditions. The LaBr3:Ce crystal exhibits an excellent time and energy resolution. Using intense collimated 137Cs and 60Co sources, the monolithic scintillator was scanned on a fine 2D grid to generate a reference library of light amplitude distributions that allows for reconstructing the photon interaction position using a k-Nearest Neighbour (k-NN) algorithm. Systematic studies were performed to investigate the performance of the reconstruction algorithm, revealing an improvement of the spatial resolution with increasing photon energy to an optimum value of 3.7(1)mm at 1.33 MeV, achieved with the Categorical Average Pattern (CAP) modification of the k-NN algorithm.

Optimising Camera Traps for Monitoring Small Mammals

PubMed Central

Glen, Alistair S.; Cockburn, Stuart; Nichols, Margaret; Ekanayake, Jagath; Warburton, Bruce

2013-01-01

Practical techniques are required to monitor invasive animals, which are often cryptic and occur at low density. Camera traps have potential for this purpose, but may have problems detecting and identifying small species. A further challenge is how to standardise the size of each camera’s field of view so capture rates are comparable between different places and times. We investigated the optimal specifications for a low-cost camera trap for small mammals. The factors tested were 1) trigger speed, 2) passive infrared vs. microwave sensor, 3) white vs. infrared flash, and 4) still photographs vs. video. We also tested a new approach to standardise each camera’s field of view. We compared the success rates of four camera trap designs in detecting and taking recognisable photographs of captive stoats ( Mustela erminea ), feral cats (Felis catus) and hedgehogs ( Erinaceus europaeus ). Trigger speeds of 0.2–2.1 s captured photographs of all three target species unless the animal was running at high speed. The camera with a microwave sensor was prone to false triggers, and often failed to trigger when an animal moved in front of it. A white flash produced photographs that were more readily identified to species than those obtained under infrared light. However, a white flash may be more likely to frighten target animals, potentially affecting detection probabilities. Video footage achieved similar success rates to still cameras but required more processing time and computer memory. Placing two camera traps side by side achieved a higher success rate than using a single camera. Camera traps show considerable promise for monitoring invasive mammal control operations. Further research should address how best to standardise the size of each camera’s field of view, maximise the probability that an animal encountering a camera trap will be detected, and eliminate visible or audible cues emitted by camera traps. PMID:23840790

Evaluation of a CdTe semiconductor based compact gamma camera for sentinel lymph node imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russo, Paolo; Curion, Assunta S.; Mettivier, Giovanni

2011-03-15

Purpose: The authors assembled a prototype compact gamma-ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinically in comparison with a conventional gamma camera. Methods: The room-temperature CdTe pixel detector (1 mm thick) has 256x256 square pixels arranged with a 55 {mu}m pitch (sensitive area 14.08x14.08 mm{sup 2}), coupled pixel-by-pixel via bump-bonding to the Medipix2 photon-counting readout CMOS integrated circuit. The imaging probe is equipped with a set of three interchangeable knife-edge pinhole collimators (0.94, 1.2, or 2.1 mm effective diametermore » at 140 keV) and its focal distance can be regulated in order to set a given field of view (FOV). A typical FOV of 70 mm at 50 mm skin-to-collimator distance corresponds to a minification factor 1:5. The detector is operated at a single low-energy threshold of about 20 keV. Results: For {sup 99m}Tc, at 50 mm distance, a background-subtracted sensitivity of 6.5x10{sup -3} cps/kBq and a system spatial resolution of 5.5 mm FWHM were obtained for the 0.94 mm pinhole; corresponding values for the 2.1 mm pinhole were 3.3x10{sup -2} cps/kBq and 12.6 mm. The dark count rate was 0.71 cps. Clinical images in three patients with melanoma indicate detection of the SLNs with acquisition times between 60 and 410 s with an injected activity of 26 MBq {sup 99m}Tc and prior localization with standard gamma camera lymphoscintigraphy. Conclusions: The laboratory performance of this imaging probe is limited by the pinhole collimator performance and the necessity of working in minification due to the limited detector size. However, in clinical operative conditions, the CdTe imaging probe was effective in detecting SLNs with adequate resolution and an acceptable sensitivity. Sensitivity is expected to improve with the future availability of a larger CdTe detector permitting operation at shorter distances from the patient skin.« less

Measurement of the Shape of the Optical-IR Spectrum of Prompt Emission from Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Grossan, Bruce; Kistaubayev, M.; Smoot, G.; Scherr, L.

2017-06-01

While the afterglow phase of gamma-ray bursts (GRBs) has been extensively measured, detections of prompt emission (i.e. during bright X-gamma emission) are more limited. Some prompt optical measurements are regularly made, but these are typically in a single wide band, with limited time resolution, and no measurement of spectral shape. Some models predict a synchrotron self-absorption spectral break somewhere in the IR-optical region. Measurement of the absorption frequency would give extensive information on each burst, including the electron Lorentz factor, the radius of emission, and more (Shen & Zhang 2008). Thus far the best prompt observations have been explained invoking a variety of models, but often with a non-unique interpretation. To understand this apparently heterogeneous behavior, and to reduce the number of possible models, it is critical to add data on the optical - IR spectral shape.Long GRB prompt X-gamma emission typically lasts ~40-80 s. The Swift BAT instrument rapidly measures GRB positions to within a few arc minutes and communicates them via the internet within a few seconds. We have measured the time for a fast-moving D=700 mm telescope to point and settle to be less than 9 s anywhere on the observable sky. Therefore, the majority of prompt optical-IR emission can be measured responding to BAT positions with this telescope. In this presentation, we describe our observing and science programs, and give our design for the Burst Simultaneous Three-channel Instrument (BSTI), which uses dichroics to send eparate bands to 3 cameras. Two EMCCD cameras, give high-time resolution in B and V; a third camera with a HgCdTe sensor covers H band, allowing us to study extinguished bursts. For a total exposure time of 10 s, we find a 5 sigma sensitivity of 21.3 and 20.3 mag in B and R for 1" seeing and Kitt Peak sky brightness, much fainter than typical previous prompt detections. We estimate 5 sigma H-band sensitivity for an IR optimized telescope to be ~16.9 mag in 20 s. With three channels broadly separated in wavelength, two separate slopes would be measured, or if present between our bands, the absorption frequency would be determined, a brand-new window into GRB physics.

Methods for increasing the sensitivity of gamma-ray imagers

DOEpatents

Mihailescu, Lucian [Pleasanton, CA; Vetter, Kai M [Alameda, CA; Chivers, Daniel H [Fremont, CA

2012-02-07

Methods are presented that increase the position resolution and granularity of double sided segmented semiconductor detectors. These methods increase the imaging resolution capability of such detectors, either used as Compton cameras, or as position sensitive radiation detectors in imagers such as SPECT, PET, coded apertures, multi-pinhole imagers, or other spatial or temporal modulated imagers.

Systems for increasing the sensitivity of gamma-ray imagers

DOEpatents

Mihailescu, Lucian; Vetter, Kai M.; Chivers, Daniel H.

2012-12-11

Systems that increase the position resolution and granularity of double sided segmented semiconductor detectors are provided. These systems increase the imaging resolution capability of such detectors, either used as Compton cameras, or as position sensitive radiation detectors in imagers such as SPECT, PET, coded apertures, multi-pinhole imagers, or other spatial or temporal modulated imagers.

Small Orbital Stereo Tracking Camera Technology Development

NASA Technical Reports Server (NTRS)

Bryan, Tom; Macleod, Todd; Gagliano, Larry

2015-01-01

On-Orbit Small Debris Tracking and Characterization is a technical gap in the current National Space Situational Awareness necessary to safeguard orbital assets and crew. This poses a major risk of MOD damage to ISS and Exploration vehicles. In 2015 this technology was added to NASA's Office of Chief Technologist roadmap. For missions flying in or assembled in or staging from LEO, the physical threat to vehicle and crew is needed in order to properly design the proper level of MOD impact shielding and proper mission design restrictions. Need to verify debris flux and size population versus ground RADAR tracking. Use of ISS for In-Situ Orbital Debris Tracking development provides attitude, power, data and orbital access without a dedicated spacecraft or restricted operations on-board a host vehicle as a secondary payload. Sensor Applicable to in-situ measuring orbital debris in flux and population in other orbits or on other vehicles. Could enhance safety on and around ISS. Some technologies extensible to monitoring of extraterrestrial debris as well to help accomplish this, new technologies must be developed quickly. The Small Orbital Stereo Tracking Camera is one such up and coming technology. It consists of flying a pair of intensified megapixel telephoto cameras to evaluate Orbital Debris (OD) monitoring in proximity of International Space Station. It will demonstrate on-orbit optical tracking (in situ) of various sized objects versus ground RADAR tracking and small OD models. The cameras are based on Flight Proven Advanced Video Guidance Sensor pixel to spot algorithms (Orbital Express) and military targeting cameras. And by using twin cameras we can provide Stereo images for ranging & mission redundancy. When pointed into the orbital velocity vector (RAM), objects approaching or near the stereo camera set can be differentiated from the stars moving upward in background.

Small Orbital Stereo Tracking Camera Technology Development

NASA Technical Reports Server (NTRS)

Bryan, Tom; MacLeod, Todd; Gagliano, Larry

2016-01-01

On-Orbit Small Debris Tracking and Characterization is a technical gap in the current National Space Situational Awareness necessary to safeguard orbital assets and crew. This poses a major risk of MOD damage to ISS and Exploration vehicles. In 2015 this technology was added to NASA's Office of Chief Technologist roadmap. For missions flying in or assembled in or staging from LEO, the physical threat to vehicle and crew is needed in order to properly design the proper level of MOD impact shielding and proper mission design restrictions. Need to verify debris flux and size population versus ground RADAR tracking. Use of ISS for In-Situ Orbital Debris Tracking development provides attitude, power, data and orbital access without a dedicated spacecraft or restricted operations on-board a host vehicle as a secondary payload. Sensor Applicable to in-situ measuring orbital debris in flux and population in other orbits or on other vehicles. Could enhance safety on and around ISS. Some technologies extensible to monitoring of extraterrestrial debris as well To help accomplish this, new technologies must be developed quickly. The Small Orbital Stereo Tracking Camera is one such up and coming technology. It consists of flying a pair of intensified megapixel telephoto cameras to evaluate Orbital Debris (OD) monitoring in proximity of International Space Station. It will demonstrate on-orbit optical tracking (in situ) of various sized objects versus ground RADAR tracking and small OD models. The cameras are based on Flight Proven Advanced Video Guidance Sensor pixel to spot algorithms (Orbital Express) and military targeting cameras. And by using twin cameras we can provide Stereo images for ranging & mission redundancy. When pointed into the orbital velocity vector (RAM), objects approaching or near the stereo camera set can be differentiated from the stars moving upward in background.

Design and Performance Testing of a Linear Array of Position-Sensitive Virtual Frisch-Grid CdZnTe Detectors for Uranium Enrichment Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ocampo, Luis

Abstract— Arrays of position-sensitive virtual Frisch-grid CdZnTe (CZT) detectors with enhanced energy resolution have been proposed for spectroscopy and imaging of gamma-ray sources in different applications. The flexibility of the array design, which can employ CZT crystals with thicknesses up to several centimeters in the direction of electron drift, allows for integration into different kinds of field-portable instruments. These can include small hand-held devices, compact gamma cameras and large field-of-view imaging systems. In this work, we present results for a small linear array of such detectors optimized for the low-energy region, 50-400 keV gamma-rays, which is principally intended for incorporationmore » into hand-held instruments. There are many potential application areas for such instruments, including uranium enrichment measurements, storage monitoring, dosimetry and other safeguards-related tasks that can benefit from compactness and isotope-identification capability. The array described here provides a relatively large area with a minimum number of readout channels, which potentially allows the developers to avoid using an ASIC-based electronic readout by substituting it with hybrid preamplifiers followed by digitizers. The array prototype consists of six (5x5.7x25 mm3) CZT detectors positioned in a line facing the source to achieve a maximum exposure area (~10 cm2). Each detector is furnished with 5 mm-wide charge-sensing pads placed near the anode. The pad signals are converted into X-Y coordinates for each interaction event, which are combined with the cathode signals (for determining the Z coordinates) to give 3D positional information for all interaction points. This information is used to correct the response non-uniformity caused by material inhomogeneity, which therefore allows the usage of standard-grade (unselected) CZT crystals, while achieving high-resolution spectroscopic performance for the instrument. In this presentation we describe the design of the array, the results from detailed laboratory tests, and preliminary results from measurements taken during a field test.« less

Long-term effects of prenatal exposure to low levels of gamma rays on open-field activity in male mice.

PubMed

Minamisawa, T; Hirokaga, K

1995-11-01

The open-field activity of first-generation (F1) hybrid male C57BL/6 x C3H mice irradiated with gamma rays on day 14 of gestation was studied at the following ages: 6-7 months (young), 12-13 months (adult) and 19-20 months (old). Doses were 0.5 Gy or 1.0 Gy. Open-field activity was recorded with a camera. The camera output signal was recorded every second through an A/D converter to a personal computer. The field was divided into 25 8-cm2 units. All recordings were continuous for 60 min. The walking speed of the 1.0-Gy group recorded at 19-20 months was higher than that for the comparably aged control group. The time which the irradiated group, recorded at 19-20 months, spent in the corner fields was high in comparison with the control group at the same age. Conversely, the time spent by the irradiated group in the middle fields when recorded at 19-20 months was shorter than in the comparably aged control group. No effect of radiation was shown for any of the behaviors observed and recorded at 6-7 and 12-13 months. The results demonstrate that such exposure to gamma rays on day 14 of gestation results in behavioral changes which occur at 19-20 months but not at 6-7 or 12-13 months.

A new variable parallel holes collimator for scintigraphic device with validation method based on Monte Carlo simulations

NASA Astrophysics Data System (ADS)

Trinci, G.; Massari, R.; Scandellari, M.; Boccalini, S.; Costantini, S.; Di Sero, R.; Basso, A.; Sala, R.; Scopinaro, F.; Soluri, A.

2010-09-01

The aim of this work is to show a new scintigraphic device able to change automatically the length of its collimator in order to adapt the spatial resolution value to gamma source distance. This patented technique replaces the need for collimator change that standard gamma cameras still feature. Monte Carlo simulations represent the best tool in searching new technological solutions for such an innovative collimation structure. They also provide a valid analysis on response of gamma cameras performances as well as on advantages and limits of this new solution. Specifically, Monte Carlo simulations are realized with GEANT4 (GEometry ANd Tracking) framework and the specific simulation object is a collimation method based on separate blocks that can be brought closer and farther, in order to reach and maintain specific spatial resolution values for all source-detector distances. To verify the accuracy and the faithfulness of these simulations, we have realized experimental measurements with identical setup and conditions. This confirms the power of the simulation as an extremely useful tool, especially where new technological solutions need to be studied, tested and analyzed before their practical realization. The final aim of this new collimation system is the improvement of the SPECT techniques, with the real control of the spatial resolution value during tomographic acquisitions. This principle did allow us to simulate a tomographic acquisition of two capillaries of radioactive solution, in order to verify the possibility to clearly distinguish them.

Lensless imaging for wide field of view

NASA Astrophysics Data System (ADS)

Nagahara, Hajime; Yagi, Yasushi

2015-02-01

It is desirable to engineer a small camera with a wide field of view (FOV) because of current developments in the field of wearable cameras and computing products, such as action cameras and Google Glass. However, typical approaches for achieving wide FOV, such as attaching a fisheye lens and convex mirrors, require a trade-off between optics size and the FOV. We propose camera optics that achieve a wide FOV, and are at the same time small and lightweight. The proposed optics are a completely lensless and catoptric design. They contain four mirrors, two for wide viewing, and two for focusing the image on the camera sensor. The proposed optics are simple and can be simply miniaturized, since we use only mirrors for the proposed optics and the optics are not susceptible to chromatic aberration. We have implemented the prototype optics of our lensless concept. We have attached the optics to commercial charge-coupled device/complementary metal oxide semiconductor cameras and conducted experiments to evaluate the feasibility of our proposed optics.

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

NASA Astrophysics Data System (ADS)

Cooper, C. M.; Pace, D. C.; Paz-Soldan, C.; Commaux, N.; Eidietis, N. W.; Hollmann, E. M.; Shiraki, D.

2016-11-01

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited).

PubMed

Cooper, C M; Pace, D C; Paz-Soldan, C; Commaux, N; Eidietis, N W; Hollmann, E M; Shiraki, D

2016-11-01

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

DOE PAGES

Cooper, C. M.; Pace, D. C.; Paz-Soldan, C.; ...

2016-08-30

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20,000 pulses permore » second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Furthermore, magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.« less

Design optimisation of a TOF-based collimated camera prototype for online hadrontherapy monitoring

NASA Astrophysics Data System (ADS)

Pinto, M.; Dauvergne, D.; Freud, N.; Krimmer, J.; Letang, J. M.; Ray, C.; Roellinghoff, F.; Testa, E.

2014-12-01

Hadrontherapy is an innovative radiation therapy modality for which one of the main key advantages is the target conformality allowed by the physical properties of ion species. However, in order to maximise the exploitation of its potentialities, online monitoring is required in order to assert the treatment quality, namely monitoring devices relying on the detection of secondary radiations. Herein is presented a method based on Monte Carlo simulations to optimise a multi-slit collimated camera employing time-of-flight selection of prompt-gamma rays to be used in a clinical scenario. In addition, an analytical tool is developed based on the Monte Carlo data to predict the expected precision for a given geometrical configuration. Such a method follows the clinical workflow requirements to simultaneously have a solution that is relatively accurate and fast. Two different camera designs are proposed, considering different endpoints based on the trade-off between camera detection efficiency and spatial resolution to be used in a proton therapy treatment with active dose delivery and assuming a homogeneous target.

SPECT detectors: the Anger Camera and beyond

PubMed Central

Peterson, Todd E.; Furenlid, Lars R.

2011-01-01

The development of radiation detectors capable of delivering spatial information about gamma-ray interactions was one of the key enabling technologies for nuclear medicine imaging and, eventually, single-photon emission computed tomography (SPECT). The continuous NaI(Tl) scintillator crystal coupled to an array of photomultiplier tubes, almost universally referred to as the Anger Camera after its inventor, has long been the dominant SPECT detector system. Nevertheless, many alternative materials and configurations have been investigated over the years. Technological advances as well as the emerging importance of specialized applications, such as cardiac and preclinical imaging, have spurred innovation such that alternatives to the Anger Camera are now part of commercial imaging systems. Increased computing power has made it practical to apply advanced signal processing and estimation schemes to make better use of the information contained in the detector signals. In this review we discuss the key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic. PMID:21828904

Upgraded cameras for the HESS imaging atmospheric Cherenkov telescopes

NASA Astrophysics Data System (ADS)

Giavitto, Gianluca; Ashton, Terry; Balzer, Arnim; Berge, David; Brun, Francois; Chaminade, Thomas; Delagnes, Eric; Fontaine, Gérard; Füßling, Matthias; Giebels, Berrie; Glicenstein, Jean-François; Gräber, Tobias; Hinton, James; Jahnke, Albert; Klepser, Stefan; Kossatz, Marko; Kretzschmann, Axel; Lefranc, Valentin; Leich, Holger; Lüdecke, Hartmut; Lypova, Iryna; Manigot, Pascal; Marandon, Vincent; Moulin, Emmanuel; de Naurois, Mathieu; Nayman, Patrick; Penno, Marek; Ross, Duncan; Salek, David; Schade, Markus; Schwab, Thomas; Simoni, Rachel; Stegmann, Christian; Steppa, Constantin; Thornhill, Julian; Toussnel, François

2016-08-01

The High Energy Stereoscopic System (H.E.S.S.) is an array of five imaging atmospheric Cherenkov telescopes, sensitive to cosmic gamma rays of energies between 30 GeV and several tens of TeV. Four of them started operations in 2003 and their photomultiplier tube (PMT) cameras are currently undergoing a major upgrade, with the goals of improving the overall performance of the array and reducing the failure rate of the ageing systems. With the exception of the 960 PMTs, all components inside the camera have been replaced: these include the readout and trigger electronics, the power, ventilation and pneumatic systems and the control and data acquisition software. New designs and technical solutions have been introduced: the readout makes use of the NECTAr analog memory chip, which samples and stores the PMT signals and was developed for the Cherenkov Telescope Array (CTA). The control of all hardware subsystems is carried out by an FPGA coupled to an embedded ARM computer, a modular design which has proven to be very fast and reliable. The new camera software is based on modern C++ libraries such as Apache Thrift, ØMQ and Protocol buffers, offering very good performance, robustness, flexibility and ease of development. The first camera was upgraded in 2015, the other three cameras are foreseen to follow in fall 2016. We describe the design, the performance, the results of the tests and the lessons learned from the first upgraded H.E.S.S. camera.

Meteor Film Recording with Digital Film Cameras with large CMOS Sensors

NASA Astrophysics Data System (ADS)

Slansky, P. C.

2016-12-01

In this article the author combines his professional know-how about cameras for film and television production with his amateur astronomy activities. Professional digital film cameras with high sensitivity are still quite rare in astronomy. One reason for this may be their costs of up to 20 000 and more (camera body only). In the interim, however,consumer photo cameras with film mode and very high sensitivity have come to the market for about 2 000 EUR. In addition, ultra-high sensitive professional film cameras, that are very interesting for meteor observation, have been introduced to the market. The particular benefits of digital film cameras with large CMOS sensors, including photo cameras with film recording function, for meteor recording are presented by three examples: a 2014 Camelopardalid, shot with a Canon EOS C 300, an exploding 2014 Aurigid, shot with a Sony alpha7S, and the 2016 Perseids, shot with a Canon ME20F-SH. All three cameras use large CMOS sensors; "large" meaning Super-35 mm, the classic 35 mm film format (24x13.5 mm, similar to APS-C size), or full format (36x24 mm), the classic 135 photo camera format. Comparisons are made to the widely used cameras with small CCD sensors, such as Mintron or Watec; "small" meaning 12" (6.4x4.8 mm) or less. Additionally, special photographic image processing of meteor film recordings is discussed.

Waste inspection tomography (WIT)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernardi, R.T.

1996-12-31

WIT is a self-sufficient mobile semitrailer for nondestructive evaluation and nondestructive assay of nuclear waste drums using x-ray and gamma-ray tomography. The recently completed Phase I included the design, fabrication, and initial testing of all WIT subsystems installed on-board the trailer. Initial test results include 2 MeV digital radiography, computed tomography, Anger camera imaging, single photon emission computed tomography, gamma-ray spectroscopy, collimated gamma scanning, and active and passive computed tomography using a 1.4 mCi source of {sup 166}Ho. These techniques were initially demonstrated on a 55-gallon phantom drum with 3 simulated waste matrices of combustibles, heterogeneous metals, and cement usingmore » check sources of gamma active isotopes such as {sup 137}Cs and {sup 133}Ba with 9-250 {mu}Ci activities. Waste matrix identification, isotopic identification, and attenuation-corrected gamma activity determination were demonstrated nondestructively and noninvasively in Phase I. Currently ongoing Phase II involves DOE site field test demonstrations at LLNL, RFETS, and INEL with real nuclear waste drums. Current WIT experience includes 55 gallon drums of cement, graphite, sludge, glass, metals, and combustibles. Thus far WIT has inspected drums with 0-20 gms of {sup 239}Pu.« less

The Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Otte, Nepomuk

The Advanced Gamma-ray Imaging System (AGIS) is a concept for the next generation of imag-ing atmospheric Cherenkov telescope arrays. It has the goal of providing an order of magnitude increase in sensitivity for Very High Energy Gamma-ray ( 100 GeV to 100 TeV) astronomy compared to currently operating arrays such as CANGAROO, HESS, MAGIC, and VERITAS. After an overview of the science such an array would enable, we discuss the development of the components of the telescope system that are required to achieve the sensitivity goal. AGIS stresses improvements in several areas of IACT technology including component reliability as well as exploring cost reduction possibilities in order to achieve its goal. We discuss alterna-tives for the telescopes and positioners: a novel Schwarzschild-Couder telescope offering a wide field of view with a relatively smaller plate scale, and possibilities for rapid slewing in order to address the search for and/or study of Gamma-ray Bursts in the VHE gamma-ray regime. We also discuss options for a high pixel count camera system providing the necessary finer solid angle per pixel and possibilities for a fast topological trigger that would offer improved realtime background rejection and lower energy thresholds.

Ultra-wide Range Gamma Detector System for Search and Locate Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Odell, D. Mackenzie Odell; Harpring, Larry J.; Moore, Frank S. Jr.

2005-10-26

Collecting debris samples following a nuclear event requires that operations be conducted from a considerable stand-off distance. An ultra-wide range gamma detector system has been constructed to accomplish both long range radiation search and close range hot sample collection functions. Constructed and tested on a REMOTEC Andros platform, the system has demonstrated reliable operation over six orders of magnitude of gamma dose from 100's of uR/hr to over 100 R/hr. Functional elements include a remotely controlled variable collimator assembly, a NaI(Tl)/photomultiplier tube detector, a proprietary digital radiation instrument, a coaxially mounted video camera, a digital compass, and both local andmore » remote control computers with a user interface designed for long range operations. Long range sensitivity and target location, as well as close range sample selection performance are presented.« less

Buried Quasars in Ultraluminous Infrared Galaxies

NASA Technical Reports Server (NTRS)

Sanders, David B.

2004-01-01

We were awarded l00OkS of INTEGRAL spacecraft time (Priority A) to observe the ultraluminous infrared galaxy (ULIG) Mrk 2273 in order io measure the integrated flux of the 20-1003 KeV gamma-Ray emission, and to use this information to search for the presence of an highly obscured active galactic nucleus (AGN). With this observation we hope to be able to better assess the role of AGN in the complete class of ULIGs and therefore to better constrain their contribution to the hard X-ray and soft gamma-ray backgrounds. Our Priority A 100 kS observation of Mrk 273 was successfully carried out during revolution #73 using 4 separate exposures with the IBIS camera during May, 2003. Our IBIS observations of Mrk 273 were successfully executed, and the source was properly centered in the Field-of-view of the detectors. We are still in the process of interpreting the IBIS gamma-ray data.

Buried Quasars in Ultra-luminous Infrared Galaxies

NASA Technical Reports Server (NTRS)

2004-01-01

We were awarded l00kS of INTEGRAL spacecraft time (Priority A) to observe the ultraluminous infrared galaxy (ULIG) Mrk 2273 in order to measure the integrated flux of the 20-1003 KeV gamma-Ray emission, and to use this information to search for the presence of an highly obscured active galactic nucleus (AGN). With this observation we hope to be able to better assess the role of AGN in the complete class of ULIGs and therefore to better constrain their contribution to the hard X-ray and soft gamma-ray backgrounds. Our Priority A 100 kS observation of Mrk 273 was successfully carried out during revolution #73 using 4 separate exposures with the IBIS camera during May, 2003. Our IBIS observations of Mrk 273 were successfully executed, and the source was properly centered in the Field-of-view of the detectors. We are still in the process of interpreting the IBIS gamma-ray data.

The Advanced Gamma-ray Imaging System (AGIS): Telescope Mechanical Designs

NASA Astrophysics Data System (ADS)

Guarino, V.; Buckley, J.; Byrum, K.; Falcone, A.; Fegan, S.; Finley, J.; Hanna, D.; Horan, D.; Kaaret, P.; Konopelko, A.; Krawczynski, H.; Krennrich, F.; Wagner, R.; Woods, M.; Vassiliev, V.

2008-04-01

The concept of a future ground-based gamma-ray observatory, AGIS, in the energy range 40 GeV-100 TeV is based on an array of sim 100 imaging atmospheric Cherenkov telescopes (IACTs). The anticipated improvements of AGIS sensitivity, angular resolution and reliability of operation impose demanding technological and cost requirements on the design of IACTs. The relatively inexpensive Davies-Cotton telescope design has been used in ground-based gamma-ray astronomy for almost fifty years and is an excellent option. We are also exploring alternative designs and in this submission we focus on the recent mechanical design of a two-mirror telescope with a Schwarzschild-Couder (SC) optical system. The mechanical structure provides support points for mirrors and camera. The design was driven by the requirement of minimizing the deflections of the mirror support structures. The structure is also designed to be able to slew in elevation and azimuth at 10 degrees/sec.

Gamma-ray spectroscopy at MHz counting rates with a compact LaBr3 detector and silicon photomultipliers for fusion plasma applications.

PubMed

Nocente, M; Rigamonti, D; Perseo, V; Tardocchi, M; Boltruczyk, G; Broslawski, A; Cremona, A; Croci, G; Gosk, M; Kiptily, V; Korolczuk, S; Mazzocco, M; Muraro, A; Strano, E; Zychor, I; Gorini, G

2016-11-01

Gamma-ray spectroscopy measurements at MHz counting rates have been carried out, for the first time, with a compact spectrometer based on a LaBr 3 scintillator and silicon photomultipliers. The instrument, which is also insensitive to magnetic fields, has been developed in view of the upgrade of the gamma-ray camera diagnostic for α particle measurements in deuterium-tritium plasmas of the Joint European Torus. Spectra were measured up to 2.9 MHz with a projected energy resolution of 3%-4% in the 3-5 MeV range, of interest for fast ion physics studies in fusion plasmas. The results reported here pave the way to first time measurements of the confined α particle profile in high power plasmas of the next deuterium-tritium campaign at the Joint European Torus.

Two Persons with Multiple Disabilities Use Camera-Based Microswitch Technology to Control Stimulation with Small Mouth and Eyelid Responses

ERIC Educational Resources Information Center

Lancioni, Giulio E.; Bellini, Domenico; Oliva, Doretta; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Lang, Russell

2012-01-01

Background: A camera-based microswitch technology was recently developed to monitor small facial responses of persons with multiple disabilities and allow those responses to control environmental stimulation. This study assessed such a technology with 2 new participants using slight variations of previous responses. Method: The technology involved…

Uncertainty propagation for SPECT/CT-based renal dosimetry in 177Lu peptide receptor radionuclide therapy

NASA Astrophysics Data System (ADS)

Gustafsson, Johan; Brolin, Gustav; Cox, Maurice; Ljungberg, Michael; Johansson, Lena; Sjögreen Gleisner, Katarina

2015-11-01

A computer model of a patient-specific clinical 177Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of 177Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the gamma-camera calibration via measurement of the system sensitivity, selection of imaging time points, generation of mass-density maps from CT, SPECT imaging, volume-of-interest delineation, calculation of absorbed-dose rate via a combination of local energy deposition for electrons and Monte Carlo simulations of photons, curve fitting and integration to absorbed dose and BED. By introducing variabilities in these steps the combined uncertainty in the output quantity is determined. The importance of different sources of uncertainty is assessed by observing the decrease in standard deviation when removing a particular source. The obtained absorbed dose and BED standard deviations are approximately 6% and slightly higher if considering the root mean square error. The most important sources of variability are the compensation for partial volume effects via a recovery coefficient and the gamma-camera calibration via the system sensitivity.

SONTRAC: A High Efficiency Solar Neutron Telescope

NASA Astrophysics Data System (ADS)

Wunderer, C. B.; Macri, J.; McConnell, M. L.; Ryan, J. M.; Baltgalvis, J.; Holslin, D.; Polichar, A.; Jenkins, T.

1997-05-01

Solar flare neutron emission between 20 and 100 MeV comes from a portion of the energetic proton spectrum that is poorly sampled by both nuclear-line and pion- decay gamma rays. SONTRAC is a new generation solar neutron telescope/spectrometer consisting of densely packed, alternating orthogonal layers of scintillating plastic fibers. The fibers in both dimensions are viewed by image intensifiers and CCD cameras. Incident neutrons scatter off hydrogen in the plastic scintillator. The resulting ionizing proton tracks can be reconstructed in three dimensions using the two planar CCD track images. Two neutron-proton scatters provide sufficient information to reconstruct the energy and direction of the incident neutron. Photomultiplier tubes view the other sides of the fiber scintillator array. The signals from the PMTs are used to give an additional measure of the proton energies and to provide a trigger for the CCD cameras. Recent technological advances have allowed us to construct an affordable working prototype instrument that consists of all the essential technical elements mentioned above. We will present images of tracks produced by minimum ionizing muons and energetic neutrons. We will also present efficiency estimates for SONTRAC's ability to detect and measure gamma rays above 10 MeV.

Camera trap placement and the potential for bias due to trails and other features

PubMed Central

Forrester, Tavis D.

2017-01-01

Camera trapping has become an increasingly widespread tool for wildlife ecologists, with large numbers of studies relying on photo capture rates or presence/absence information. It is increasingly clear that camera placement can directly impact this kind of data, yet these biases are poorly understood. We used a paired camera design to investigate the effect of small-scale habitat features on species richness estimates, and capture rate and detection probability of several mammal species in the Shenandoah Valley of Virginia, USA. Cameras were deployed at either log features or on game trails with a paired camera at a nearby random location. Overall capture rates were significantly higher at trail and log cameras compared to their paired random cameras, and some species showed capture rates as much as 9.7 times greater at feature-based cameras. We recorded more species at both log (17) and trail features (15) than at their paired control cameras (13 and 12 species, respectively), yet richness estimates were indistinguishable after 659 and 385 camera nights of survey effort, respectively. We detected significant increases (ranging from 11–33%) in detection probability for five species resulting from the presence of game trails. For six species detection probability was also influenced by the presence of a log feature. This bias was most pronounced for the three rodents investigated, where in all cases detection probability was substantially higher (24.9–38.2%) at log cameras. Our results indicate that small-scale factors, including the presence of game trails and other features, can have significant impacts on species detection when camera traps are employed. Significant biases may result if the presence and quality of these features are not documented and either incorporated into analytical procedures, or controlled for in study design. PMID:29045478

Camera trap placement and the potential for bias due to trails and other features.

PubMed

Kolowski, Joseph M; Forrester, Tavis D

2017-01-01

Camera trapping has become an increasingly widespread tool for wildlife ecologists, with large numbers of studies relying on photo capture rates or presence/absence information. It is increasingly clear that camera placement can directly impact this kind of data, yet these biases are poorly understood. We used a paired camera design to investigate the effect of small-scale habitat features on species richness estimates, and capture rate and detection probability of several mammal species in the Shenandoah Valley of Virginia, USA. Cameras were deployed at either log features or on game trails with a paired camera at a nearby random location. Overall capture rates were significantly higher at trail and log cameras compared to their paired random cameras, and some species showed capture rates as much as 9.7 times greater at feature-based cameras. We recorded more species at both log (17) and trail features (15) than at their paired control cameras (13 and 12 species, respectively), yet richness estimates were indistinguishable after 659 and 385 camera nights of survey effort, respectively. We detected significant increases (ranging from 11-33%) in detection probability for five species resulting from the presence of game trails. For six species detection probability was also influenced by the presence of a log feature. This bias was most pronounced for the three rodents investigated, where in all cases detection probability was substantially higher (24.9-38.2%) at log cameras. Our results indicate that small-scale factors, including the presence of game trails and other features, can have significant impacts on species detection when camera traps are employed. Significant biases may result if the presence and quality of these features are not documented and either incorporated into analytical procedures, or controlled for in study design.

Collimator-free photon tomography

DOEpatents

Dilmanian, F.A.; Barbour, R.L.

1998-10-06

A method of uncollimated single photon emission computed tomography includes administering a radioisotope to a patient for producing gamma ray photons from a source inside the patient. Emissivity of the photons is measured externally of the patient with an uncollimated gamma camera at a plurality of measurement positions surrounding the patient for obtaining corresponding energy spectrums thereat. Photon emissivity at the plurality of measurement positions is predicted using an initial prediction of an image of the source. The predicted and measured photon emissivities are compared to obtain differences therebetween. Prediction and comparison is iterated by updating the image prediction until the differences are below a threshold for obtaining a final prediction of the source image. 6 figs.

Generic Learning-Based Ensemble Framework for Small Sample Size Face Recognition in Multi-Camera Networks.

PubMed

Zhang, Cuicui; Liang, Xuefeng; Matsuyama, Takashi

2014-12-08

Multi-camera networks have gained great interest in video-based surveillance systems for security monitoring, access control, etc. Person re-identification is an essential and challenging task in multi-camera networks, which aims to determine if a given individual has already appeared over the camera network. Individual recognition often uses faces as a trial and requires a large number of samples during the training phrase. This is difficult to fulfill due to the limitation of the camera hardware system and the unconstrained image capturing conditions. Conventional face recognition algorithms often encounter the "small sample size" (SSS) problem arising from the small number of training samples compared to the high dimensionality of the sample space. To overcome this problem, interest in the combination of multiple base classifiers has sparked research efforts in ensemble methods. However, existing ensemble methods still open two questions: (1) how to define diverse base classifiers from the small data; (2) how to avoid the diversity/accuracy dilemma occurring during ensemble. To address these problems, this paper proposes a novel generic learning-based ensemble framework, which augments the small data by generating new samples based on a generic distribution and introduces a tailored 0-1 knapsack algorithm to alleviate the diversity/accuracy dilemma. More diverse base classifiers can be generated from the expanded face space, and more appropriate base classifiers are selected for ensemble. Extensive experimental results on four benchmarks demonstrate the higher ability of our system to cope with the SSS problem compared to the state-of-the-art system.

Generic Learning-Based Ensemble Framework for Small Sample Size Face Recognition in Multi-Camera Networks

PubMed Central

Zhang, Cuicui; Liang, Xuefeng; Matsuyama, Takashi

2014-01-01

Multi-camera networks have gained great interest in video-based surveillance systems for security monitoring, access control, etc. Person re-identification is an essential and challenging task in multi-camera networks, which aims to determine if a given individual has already appeared over the camera network. Individual recognition often uses faces as a trial and requires a large number of samples during the training phrase. This is difficult to fulfill due to the limitation of the camera hardware system and the unconstrained image capturing conditions. Conventional face recognition algorithms often encounter the “small sample size” (SSS) problem arising from the small number of training samples compared to the high dimensionality of the sample space. To overcome this problem, interest in the combination of multiple base classifiers has sparked research efforts in ensemble methods. However, existing ensemble methods still open two questions: (1) how to define diverse base classifiers from the small data; (2) how to avoid the diversity/accuracy dilemma occurring during ensemble. To address these problems, this paper proposes a novel generic learning-based ensemble framework, which augments the small data by generating new samples based on a generic distribution and introduces a tailored 0–1 knapsack algorithm to alleviate the diversity/accuracy dilemma. More diverse base classifiers can be generated from the expanded face space, and more appropriate base classifiers are selected for ensemble. Extensive experimental results on four benchmarks demonstrate the higher ability of our system to cope with the SSS problem compared to the state-of-the-art system. PMID:25494350

Photo-guided sentinel node mapping in breast cancer using marker-free photo-gamma fusion lymphoscintigraphy.

PubMed

Lee, Eun Seong; Chun, In Kook; Ha, Seunggyun; Yoon, Hai-Jeon; Jung, So-Youn; Lee, Seeyoun; Kim, Seok Won; Lee, Eun Sook; Kim, Taeyoon; Kim, Kwang Gi; Lee, Byung Il; Kim, Tae Sung; Kim, Seok-Ki

2013-03-01

Photo-gamma fusion lymphoscintigraphy (PGFLS) was developed by overlying a conventional planar gamma image on a photograph for the guidance of sentinel node biopsy. The feasibility and accuracy of PGFLS was assessed in breast cancer patients. A digital camera and a gamma camera were coordinated to obtain photograph and gamma images from the same angle. Using the distance to the object and calibration acquisition with a flat phantom and radioactive markers, PGFLS was performed both in phantom and in patients without fiducial markers. Marker-free PGFLS was verified using flat phantom, anthropomorphic phantom with markers simulating sentinel nodes and breast cancer patients. In addition, the depth of the radioactive marker or sentinel node was calculated using two gamma images taken at right angles. The feasibility and accuracy of PGFLS were assessed in terms of mismatch errors of co-registration and depth with reference to the data from SPECT/CT. The mismatch error was less than 6 mm in the flat phantom image at a distance from 50 to 62 cm without misalignment. In the anthropomorphic phantom study, co-registration error was 0.42 ± 0.29 cm; depth error was 0.51 ± 0.37 cm, which was well correlated with the reference value on SPECT/CT (x scale: R(2) = 0.99, p < 0.01; y scale: R(2) = 0.99, p < 0.01; depth: R(2) = 0.99, p < 0.01). In ten patients with breast cancer referred for lympho-SPECT/CT, PGFSL enabled photo-guided sentinel lymph node mapping with acceptable accuracy (co-registration error, 0.47 ± 0.24 cm; depth error, 1.20 ±0.41 cm). The results from PGFSL showed close correlation with those from SPECT/CT (x scale: R(2) = 0.99, p < 0.01; y scale: R(2) = 0.98, p < 0.01; depth: R(2) = 0.77, p < 0.01). The novel and convenient PGFLS technique is clinically feasible, showing acceptable accuracy and providing additional visual and quantitative information for sentinel lymph node mapping. This approach will facilitate photo-guided sentinel lymph node dissection in breast cancer.

A new gamma ray imaging diagnostic for runaway electron studies at DIII-D

NASA Astrophysics Data System (ADS)

Cooper, C. M.; Pace, D. C.; Eidietis, N. W.; Paz-Soldan, C.; Commaux, N.; Shiraki, D.; Hollmann, E. M.; Moyer, R. A.; Risov, V.

2015-11-01

A new Gamma Ray Imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at DIII-D. The diagnostic is sensitive to 0.5 - 50 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE dissipation from pellet injection. The GRI consists of a lead ``pinhole camera'' mounted on the midplane with 11x11 counter-current tangential chords 20 cm wide that span the vessel. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE Bremsstrahlung radiation. Detectors operate in current saturation mode at 10 MHz, or the flux is attenuated for Pulse Height Analysis (PHA) capable of discriminating up to ~10k pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. Work supported by the US DOE under DE-AC05-00OR22725, DE-FG02-07ER54917 & DE-FC02-04ER54698.

FAST OPTICAL VARIABILITY OF A NAKED-EYE BURST-MANIFESTATION OF THE PERIODIC ACTIVITY OF AN INTERNAL ENGINE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beskin, G.; Karpov, S.; Bondar, S.

We imaged the position of the naked-eye burst, GRB080319B, before, during, and after its gamma-ray activity with sub-second temporal resolution using the TORTORA wide-field camera. The burst optical prompt emission, which reached 5.3 mag, has been detected, and its periodic optical variability has been discovered in the form of four equidistant flashes with a duration of several seconds. We also detected a strong correlation (r {approx} 0.82) between optical and gamma-ray light curves with a 2 s delay of the optical emission with respect to the gamma-ray emission. The revealed temporal structure of the optical light curve in comparison withmore » the gamma-ray light curve can be interpreted in the framework of the model of shell collisions in the ejecta containing a significant neutron component. All observed emission features reflect the non-stationary behavior of the burst internal engine-supposedly, a hyperaccreting solar-mass black hole formed in the collapse of a massive stellar core.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conder, A.; Mummolo, F. J.

The goal of the project was to develop a compact, large active area, high spatial resolution, high dynamic range, charge-coupled device (CCD) camera to replace film for digital imaging of visible light, ultraviolet radiation, and soft to penetrating X-rays. The camera head and controller needed to be capable of operation within a vacuum environment and small enough to be fielded within the small vacuum target chambers at LLNL.

Lunar Reconnaissance Orbiter Data Enable Science and Terrain Analysis of Potential Landing Sites in South Pole-Aitken Basin

NASA Astrophysics Data System (ADS)

Jolliff, B. L.

2017-12-01

Exploring the South Pole-Aitken basin (SPA), one of the key unsampled geologic terranes on the Moon, is a high priority for Solar System science. As the largest and oldest recognizable impact basin on the Moon, it anchors the heavy bombardment chronology. It is thus a key target for sample return to better understand the impact flux in the Solar System between formation of the Moon and 3.9 Ga when Imbrium, one of the last of the great lunar impact basins, formed. Exploration of SPA has implications for understanding early habitable environments on the terrestrial planets. Global mineralogical and compositional data exist from the Clementine UV-VIS camera, the Lunar Prospector Gamma Ray Spectrometer, the Moon Mineralogy Mapper (M3) on Chandrayaan-1, the Chang'E-1 Imaging Interferometer, the spectral suite on SELENE, and the Lunar Reconnaissance Orbiter Cameras (LROC) Wide Angle Camera (WAC) and Diviner thermal radiometer. Integration of data sets enables synergistic assessment of geology and distribution of units across multiple spatial scales. Mineralogical assessment using hyperspectral data indicates spatial relationships with mineralogical signatures, e.g., central peaks of complex craters, consistent with inferred SPA basin structure and melt differentiation (Moriarty & Pieters, 2015, JGR-P 118). Delineation of mare, cryptomare, and nonmare surfaces is key to interpreting compositional mixing in the formation of SPA regolith to interpret remotely sensed data, and for scientific assessment of landing sites. LROC Narrow Angle Camera (NAC) images show the location and distribution of >0.5 m boulders and fresh craters that constitute the main threats to automated landers and thus provide critical information for landing site assessment and planning. NAC images suitable for geometric stereo derivation and digital terrain models so derived, controlled with Lunar Orbiter Laser Altimeter (LOLA) data, and oblique NAC images made with large slews of the spacecraft, are crucial to both scientific and landing-site assessments. These images, however, require favorable illumination and significant spacecraft resources. Thus they make up only a small percentage of all of the images taken. It is essential for future exploration to support LRO continued operation for these critical datasets.

Seeing the Light: A Classroom-Sized Pinhole Camera Demonstration for Teaching Vision

ERIC Educational Resources Information Center

Prull, Matthew W.; Banks, William P.

2005-01-01

We describe a classroom-sized pinhole camera demonstration (camera obscura) designed to enhance students' learning of the visual system. The demonstration consists of a suspended rear-projection screen onto which the outside environment projects images through a small hole in a classroom window. Students can observe these images in a darkened…

Consistent Small-Sample Variances for Six Gamma-Family Measures of Ordinal Association

ERIC Educational Resources Information Center

Woods, Carol M.

2009-01-01

Gamma-family measures are bivariate ordinal correlation measures that form a family because they all reduce to Goodman and Kruskal's gamma in the absence of ties (1954). For several gamma-family indices, more than one variance estimator has been introduced. In previous research, the "consistent" variance estimator described by Cliff and…

PPAR-{gamma} agonist protects against intestinal injury during necrotizing enterocolitis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baregamian, Naira; Mourot, Joshua M.; Ballard, Amie R.

2009-02-06

Necrotizing enterocolitis (NEC) remains a lethal condition for many premature infants. Peroxisome proliferator-activated receptor-{gamma} (PPAR-{gamma}), a member of the nuclear hormone receptor family, has been shown to play a protective role in cellular inflammatory responses; however, its role in NEC is not clearly defined. We sought to examine the expression of PPAR-{gamma} in the intestine using an ischemia-reperfusion (I/R) model of NEC, and to assess whether PPAR-{gamma} agonist treatment would ameliorate I/R-induced gut injury. Swiss-Webster mice were randomized to receive sham (control) or I/R injury to the gut induced by transient occlusion of superior mesenteric artery for 45 min withmore » variable periods of reperfusion. I/R injury resulted in early induction of PPAR-{gamma} expression and activation of NF-{kappa}B in small intestine. Pretreatment with PPAR-{gamma} agonist, 15d-PGJ{sub 2}, attenuated intestinal NF-{kappa}B response and I/R-induced gut injury. Activation of PPAR-{gamma} demonstrated a protective effect on small bowel during I/R-induced gut injury.« less

Prompt gamma-ray imaging for small animals

NASA Astrophysics Data System (ADS)

Xu, Libai

Small animal imaging is recognized as a powerful discovery tool for small animal modeling of human diseases, which is providing an important clue to complete understanding of disease mechanisms and is helping researchers develop and test new treatments. The current small animal imaging techniques include positron emission tomography (PET), single photon emission tomography (SPECT), computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US). A new imaging modality called prompt gamma-ray imaging (PGI) has been identified and investigated primarily by Monte Carlo simulation. Currently it is suggested for use on small animals. This new technique could greatly enhance and extend the present capabilities of PET and SPECT imaging from ingested radioisotopes to the imaging of selected non-radioactive elements, such as Gd, Cd, Hg, and B, and has the great potential to be used in Neutron Cancer Therapy to monitor neutron distribution and neutron-capture agent distribution. This approach consists of irradiating small animals in the thermal neutron beam of a nuclear reactor to produce prompt gamma rays from the elements in the sample by the radiative capture (n, gamma) reaction. These prompt gamma rays are emitted in energies that are characteristic of each element and they are also produced in characteristic coincident chains. After measuring these prompt gamma rays by surrounding spectrometry array, the distribution of each element of interest in the sample is reconstructed from the mapping of each detected signature gamma ray by either electronic collimations or mechanical collimations. In addition, the transmitted neutrons from the beam can be simultaneously used for very sensitive anatomical imaging, which provides the registration for the elemental distributions obtained from PGI. The primary approach is to use Monte Carlo simulation methods either with the specific purpose code CEARCPG, developed at NC State University or with the general purpose codes GEANT4 or MCNP5, to predict results and investigate the feasibility of this new imaging idea. Benchmark experiments have been conducted to test the capability of the code to simulate prompt gamma rays, which are produced by following the nuclear structures of each irradiated isotope, and coincidence counting techniques, which are considered the most important improvement in neutron-related gamma-ray detection applications to reduce gamma background and improve system signal-to-noise ratios. With coincidence prompt gamma rays available, two major imaging techniques, electronic collimations and mechanic collimations, are implemented in the simulation to illustrate the feasibility of imaging elemental distribution by this new technique. The expectation maximization algorithm is employed in electronic collimation to reconstruct images. The common SPECT imaging algorithms are used in mechanical collimation to get an image. Several critical topics concerning practical applications have already been discussed, such as the radiation dose to the mouse and the detection efficiency of high-energy gamma rays. The funding of this work is provided by the Center for Engineering Application of Radioisotopes (CEAR) at North Carolina State University (NCSU) and Nuclear Engineering Education Research.

Colorimetric calibration of wound photography with off-the-shelf devices

NASA Astrophysics Data System (ADS)

Bala, Subhankar; Sirazitdinova, Ekaterina; Deserno, Thomas M.

2017-03-01

Digital cameras are often used in recent days for photographic documentation in medical sciences. However, color reproducibility of same objects suffers from different illuminations and lighting conditions. This variation in color representation is problematic when the images are used for segmentation and measurements based on color thresholds. In this paper, motivated by photographic follow-up of chronic wounds, we assess the impact of (i) gamma correction, (ii) white balancing, (iii) background unification, and (iv) reference card-based color correction. Automatic gamma correction and white balancing are applied to support the calibration procedure, where gamma correction is a nonlinear color transform. For unevenly illuminated images, non- uniform illumination correction is applied. In the last step, we apply colorimetric calibration using a reference color card of 24 patches with known colors. A lattice detection algorithm is used for locating the card. The least squares algorithm is applied for affine color calibration in the RGB model. We have tested the algorithm on images with seven different types of illumination: with and without flash using three different off-the-shelf cameras including smartphones. We analyzed the spread of resulting color value of selected color patch before and after applying the calibration. Additionally, we checked the individual contribution of different steps of the whole calibration process. Using all steps, we were able to achieve a maximum of 81% reduction in standard deviation of color patch values in resulting images comparing to the original images. That supports manual as well as automatic quantitative wound assessments with off-the-shelf devices.

Characterization of scintillator crystals for usage as prompt gamma monitors in particle therapy

NASA Astrophysics Data System (ADS)

Roemer, K.; Pausch, G.; Bemmerer, D.; Berthel, M.; Dreyer, A.; Golnik, C.; Hueso-González, F.; Kormoll, T.; Petzoldt, J.; Rohling, H.; Thirolf, P.; Wagner, A.; Wagner, L.; Weinberger, D.; Fiedler, F.

2015-10-01

Particle therapy in oncology is advantageous compared to classical radiotherapy due to its well-defined penetration depth. In the so-called Bragg peak, the highest dose is deposited; the tissue behind the cancerous area is not exposed. Different factors influence the range of the particle and thus the target area, e.g. organ motion, mispositioning of the patient or anatomical changes. In order to avoid over-exposure of healthy tissue and under-dosage of cancerous regions, the penetration depth of the particle has to be monitored, preferably already during the ongoing therapy session. The verification of the ion range can be performed using prompt gamma emissions, which are produced by interactions between projectile and tissue, and originate from the same location and time of the nuclear reaction. The prompt gamma emission profile and the clinically relevant penetration depth are correlated. Various imaging concepts based on the detection of prompt gamma rays are currently discussed: collimated systems with counting detectors, Compton cameras with (at least) two detector planes, or the prompt gamma timing method, utilizing the particle time-of-flight within the body. For each concept, the detection system must meet special requirements regarding energy, time, and spatial resolution. Nonetheless, the prerequisites remain the same: the gamma energy region (2 to 10 MeV), high counting rates and the stability in strong background radiation fields. The aim of this work is the comparison of different scintillation crystals regarding energy and time resolution for optimized prompt gamma detection.

Geomorphological Analysis of Lunar Swirls: Insights from LROC-NAC

NASA Astrophysics Data System (ADS)

Jozwiak, L. M.; Blewett, D. T.

2017-12-01

The enigmatic features known as lunar swirls are a set of high-reflectance, sinuous features observed in both mare and highland settings, and often associated with crustal magnetic anomalies. There are several hypotheses for the formation of swirls, including atypical space weathering resulting from solar wind stand-off, disruption of regolith structure and imposition of a magnetic field associated with recent cometary impacts, and levitation and magnetic sorting of fine-grained dust. Investigations utilizing data from Diviner and Mini-RF suggest that, at the scales sensed by the instruments, regolith in swirl regions is indistinguishable from regolith in non-swirl regions. We have used data from the LRO Camera-Narrow Angle Camera to study the structure of lunar swirls, and explore whether the high-reflectance material associated with lunar swirls represents a discrete deposit. We assessed the populations of impact craters with diameter greater than 1 km on the Reiner Gamma swirl and on a nearby region of lunar mare located on the same lava flow unit, and determined that the crater populations suggest that the presence of the swirl does not affect the background impact crater population. We also investigated whether small (D < 0.5 km) superposed impact craters showed evidence for excavation of material from beneath a hypothetical surficial swirl deposit. Investigating the swirls located at Reiner Gamma, Mare Ingenii, Mare Marginis, and the crater Gerasimovich and adjacent non-swirl regions, we observed high-reflectance ejecta deposits whose morphology and degradation are consistent with space weathering processes. We further observe the relative proportion of these high-reflectance excavations to be greater in the swirl regions, suggesting a qualitatively slower space weathering process in these regions. In all regions, we also observed the excavation of low-reflectance material distributed in the ejecta deposit of superposed craters with a wide range of diameters, and a wide range of distribution patterns. We also observe these dark materials in non-swirl regions, suggesting they are not unique to the swirl environment. Our investigations are consistent with the atypical space weathering hypothesis.

A celestial gamma-ray foreground due to the albedo of small solar system bodies and a remote probe of the interstellar cosmic ray spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, Igor V.; Porter, Troy A.; Digel, Seth W.

2007-12-17

We calculate the {gamma}-ray albedo flux from cosmic-ray (CR) interactions with the solid rock and ice in Main Belt asteroids and Kuiper Belt objects (KBOs) using the Moon as a template. We show that the {gamma}-ray albedo for the Main Belt and Kuiper Belt strongly depends on the small-body mass spectrum of each system and may be detectable by the forthcoming Gamma Ray Large Area Space Telescope (GLAST). The orbits of the Main Belt asteroids and KBOs are distributed near the ecliptic, which passes through the Galactic center and high Galactic latitudes. If detected, the {gamma}-ray emission by the Mainmore » Belt and Kuiper Belt has to be taken into account when analyzing weak {gamma}-ray sources close to the ecliptic, especially near the Galactic center and for signals at high Galactic latitudes, such as the extragalactic {gamma}-ray emission. Additionally, it can be used to probe the spectrum of CR nuclei at close-to-interstellar conditions, and the mass spectrum of small bodies in the Main Belt and Kuiper Belt. The asteroid albedo spectrum also exhibits a 511 keV line due to secondary positrons annihilating in the rock. This may be an important and previously unrecognized celestial foreground for the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) observations of the Galactic 511 keV line emission including the direction of the Galactic center.« less

A Major Upgrade of the H.E.S.S. Cherenkov Cameras

NASA Astrophysics Data System (ADS)

Lypova, Iryna; Giavitto, Gianluca; Ashton, Terry; Balzer, Arnim; Berge, David; Brun, Francois; Chaminade, Thomas; Delagnes, Eric; Fontaine, Gerard; Füßling, Matthias; Giebels, Berrie; Glicenstein, Jean-Francois; Gräber, Tobias; Hinton, Jim; Jahnke, Albert; Klepser, Stefan; Kossatz, Marko; Kretzschmann, Axel; Lefranc, Valentin; Leich, Holger; Lüdecke, Hartmut; Manigot, Pascal; Marandon, Vincent; Moulin, Emmanuel; de Naurois, Mathieu; Nayman, Patrick; Ohm, Stefan; Penno, Marek; Ross, Duncan; Salek, David; Schade, Markus; Schwab, Thomas; Simoni, Rachel; Stegmann, Christian; Steppa, Constantin; Thornhill, Julian; Toussnel, Francois

2017-03-01

The High Energy Stereoscopic System (H.E.S.S.) is an array of imaging atmospheric Cherenkov telescopes (IACTs) located in Namibia. It was built to detect Very High Energy (VHE, >100 GeV) cosmic gamma rays, and consists of four 12 m diameter Cherenkov telescopes (CT1-4), built in 2003, and a larger 28 m telescope (CT5), built in 2012. The larger mirror surface of CT5 permits to lower the energy threshold of the array down to 30 GeV. The cameras of CT1-4 are currently undergoing an extensive upgrade, with the goals of reducing their failure rate, reducing their readout dead time and improving the overall performance of the array. The entire camera electronics has been renewed from ground-up, as well as the power, ventilation and pneumatics systems, and the control and data acquisition software. Technical solutions forseen for the next-generation Cherenkov Telescope Array (CTA) observatory have been introduced, most notably the readout is based on the NECTAr analog memory chip. The camera control subsystems and the control software framework also pursue an innovative design, increasing the camera performance, robustness and flexibility. The CT1 camera has been upgraded in July 2015 and is currently taking data; CT2-4 will upgraded in Fall 2016. Together they will assure continuous operation of H.E.S.S at its full sensitivity until and possibly beyond the advent of CTA. This contribution describes the design, the testing and the in-lab and on-site performance of all components of the newly upgraded H.E.S.S. camera.

Development of a multi-knife-edge slit collimator for prompt gamma ray imaging during proton beam cancer therapy

NASA Astrophysics Data System (ADS)

Ready, John Francis, III

Proton beam usage to treat cancer has recently experienced rapid growth, as it offers the ability to target dose delivery in a patient more precisely than traditional x-ray treatment methods. Protons stop within the patient, delivering the maximum dose at the end of their track--a phenomenon described as the Bragg peak. However, because a large dose is delivered to a small volume, proton therapy is very sensitive to errors in patient setup and treatment planning calculations. Additionally, because all primary beam particles stop in the patient, there is no direct information available to verify dose delivery. These factors contribute to the range uncertainty in proton therapy, which ultimately hinders its clinical usefulness. A reliable method of proton range verification would allow the clinician to fully utilize the precise dose delivery of the Bragg peak. Several methods to verify proton range detect secondary emissions, especially prompt gamma ray (PG) emissions. However, detection of PGs is challenging due to their high energy (2-10 MeV) and low attenuation coefficients, which limit PG interactions in materials. Therefore, detection and collimation methods must be specifically designed for prompt gamma ray imaging (PGI) applications. In addition, production of PGs relies on delivering a dose of radiation to the patient. Ideally, verification of the Bragg peak location exposes patients to a minimal dose, thus limiting the PG counts available to the imaging system. An additional challenge for PGI is the lack of accurate simulation models, which limit the study of PG production characteristics and the relationship between PG distribution and dose delivery. Specific limitations include incorrect modeling of the reaction cross sections, gamma emission yields, and angular distribution of emission for specific photon energies. While simulations can still be valuable assets in designing a system to detect and image PGs, until new models are developed and incorporated into Monte Carlo simulation packages, simulations cannot be used to study the production and location of PG emissions during proton therapy. This work presents a novel system to image PGs emitted during proton therapy to verify proton beam range. The imaging system consists of a multi-slit collimator paired with a position-sensitive LSO scintillation detector. This innovative design is the first collimated imaging system to implement two-dimensional (2-D) imaging for PG proton beam range verification, while also providing a larger field of view than compared to single-slit collimator systems. Other, uncollimated imaging systems have been explored for PGI applications, such as Compton cameras. However, Compton camera designs are severely limited by counting rate capabilities. A recent Compton camera study reported count rate capability of about 5 kHz. However, at a typical clinical beam current of 1.0 nA, the estimated PG emission rate would be 6 x 108 per second. After accounting for distance to the detector and interaction efficiencies, the detection system will still be overwhelmed with counts in the MHz range, causing false coincidences and hindering the operation of the imaging system. Initial measurements using 50 MeV protons demonstrated the ability of our system to reconstruct 2-D PG distributions at clinical beam currents. A Bragg peak localization precision of 1 mm (2sigma) was achieved with delivery of (1.7 +/- 0.8) x 108 protons into a PMMA target, suggesting the ability of the system to detect relative shifts in proton range while delivering fewer protons than used in a typical treatment fraction. This is key, as the ideal system allows the clinician to verify proton range when delivering only a small portion of the prescribed dose, preventing the mistreatment of the patient. Additionally, the absolute position of the Bragg peak was identified to within 1.6 mm (2sigma) with 5.6 x 1010 protons delivered. These promising results warrant further investigation and system optimization for clinical implementation. While further measurements at clinical beam energy levels will be required to verify system performance, these preliminary results provide evidence that 2-D image reconstruction, with 1-2 mm accuracy, is possible with this design. Implementing such a system in the clinical setting would greatly improve proton therapy cancer treatment outcomes.

Evaluation of a CdTe semiconductor based compact γ camera for sentinel lymph node imaging.

PubMed

Russo, Paolo; Curion, Assunta S; Mettivier, Giovanni; Esposito, Michela; Aurilio, Michela; Caracò, Corradina; Aloj, Luigi; Lastoria, Secondo

2011-03-01

The authors assembled a prototype compact gamma-ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinically in comparison with a conventional gamma camera. The room-temperature CdTe pixel detector (1 mm thick) has 256 x 256 square pixels arranged with a 55 microm pitch (sensitive area 14.08 x 14.08 mm2), coupled pixel-by-pixel via bump-bonding to the Medipix2 photon-counting readout CMOS integrated circuit. The imaging probe is equipped with a set of three interchangeable knife-edge pinhole collimators (0.94, 1.2, or 2.1 mm effective diameter at 140 keV) and its focal distance can be regulated in order to set a given field of view (FOV). A typical FOV of 70 mm at 50 mm skin-to-collimator distance corresponds to a minification factor 1:5. The detector is operated at a single low-energy threshold of about 20 keV. For 99 mTc, at 50 mm distance, a background-subtracted sensitivity of 6.5 x 10(-3) cps/kBq and a system spatial resolution of 5.5 mm FWHM were obtained for the 0.94 mm pinhole; corresponding values for the 2.1 mm pinhole were 3.3 x 10(-2) cps/kBq and 12.6 mm. The dark count rate was 0.71 cps. Clinical images in three patients with melanoma indicate detection of the SLNs with acquisition times between 60 and 410 s with an injected activity of 26 MBq 99 mTc and prior localization with standard gamma camera lymphoscintigraphy. The laboratory performance of this imaging probe is limited by the pinhole collimator performance and the necessity of working in minification due to the limited detector size. However, in clinical operative conditions, the CdTe imaging probe was effective in detecting SLNs with adequate resolution and an acceptable sensitivity. Sensitivity is expected to improve with the future availability of a larger CdTe detector permitting operation at shorter distances from the patient skin.

Nuclear medicine image registration by spatially noncoherent interferometry.

PubMed

Scheiber, C; Malet, Y; Sirat, G; Grucker, D

2000-02-01

This article introduces a technique for obtaining high-resolution body contour data in the same coordinate frame as that of a rotating gamma camera, using a miniature range finder, the conoscope, mounted on the camera gantry. One potential application of the technique is accurate coregistration in longitudinal brain SPECT studies, using the face of the patient (or "mask"), instead of SPECT slices, to coregister subsequent acquisitions involving the brain. Conoscopic holography is an interferometry technique that relies on spatially incoherent light interference in birefringent crystals. In this study, the conoscope was used to measure the absolute distance (Z) between a light source reflected from the skin and its observation plane. This light was emitted by a 0.2-mW laser diode. A scanning system was used to image the face during SPECT acquisition. The system consisted of a motor-driven mirror (Y axis) and the gamma-camera gantry (1 profile was obtained for each rotation step, X axis). The system was calibrated to place the conoscopic measurements and SPECT slices in the same coordinate frame. Through a simple and robust calibration of the system, the SE for measurements performed on geometric shapes was less than 2 mm, i.e., less than the actual pixel size of the SPECT data. Biometric measurements of an anthropomorphic brain phantom were within 3%-5% of actual values. The mask data were used to register images of a brain phantom and of a volunteer's brain, respectively. The rigid transformation that allowed the merging of masks by visual inspection was applied to the 2 sets of SPECT slices to perform the fusion of the data. At the cost of an additional low-cost setup integrated into the gamma-camera gantry, real-time data about the surface of the head were obtained. As in all other surface-based techniques (as opposed to volume-based techniques), this method allows the match of data independently from the dataset of interest and facilitates further registration of data from any other source. The main advantage of this technique compared with other optically based methods is the robustness of the calibration procedure and the compactness of the sensor as a result of the colinearity of the projected beam and the reflected (diffused) beams of the conoscope. Taking into account the experimental nature of this preliminary work, significant improvements in the accuracy and speed of measurements (up to 1000 points/s) are expected.

Critical examination of the uniformity requirements for single-photon emission computed tomography.

PubMed

O'Connor, M K; Vermeersch, C

1991-01-01

It is generally recognized that single-photon emission computed tomography (SPECT) imposes very stringent requirements on gamma camera uniformity to prevent the occurrence of ring artifacts. The purpose of this study was to examine the relationship between nonuniformities in the planar data and the magnitude of the consequential ring artifacts in the transaxial data, and how the perception of these artifacts is influenced by factors such as reconstruction matrix size, reconstruction filter, and image noise. The study indicates that the relationship between ring artifact magnitude and image noise is essentially independent of the acquisition or reconstruction matrix sizes, but is strongly dependent upon the type of smoothing filter applied during the reconstruction process. Furthermore, the degree to which a ring artifact can be perceived above image noise is dependent on the size and location of the nonuniformity in the planar data, with small nonuniformities (1-2 pixels wide) close to the center of rotation being less perceptible than those further out (8-20 pixels). Small defects or nonuniformities close to the center of rotation are thought to cause the greatest potential corruption to tomographic data. The study indicates that such may not be the case. Hence the uniformity requirements for SPECT may be less demanding than was previously thought.

Development of an instrument for time activity curve measurements during PET imaging of rodents

NASA Astrophysics Data System (ADS)

Reymond, Jean-Marc; Guez, David; Kerhoas, Sophie; Mangeot, Philippe; Boisgard, Raphaël; Jan, Sébastien; Tavitian, Bertrand; Trebossen, Régine

2007-02-01

Molecular imaging using PET in small rodents requires commonly the knowledge of the input function of the tracer (quantitative and kinetic studies of the metabolism, development of new drugs or new tracers, etc.). In this paper, we report the status and the performances of the prototype of a counting system that is under development at DAPNIA a in collaboration with SHFJ b. The detection device is made of silicon diodes of 0.3 mm thickness proper to measure the positrons emitted by the radiotracer contained in arterial blood flowing in a thin-wall microtube. Such diodes are poorly efficient for the 511 keV gammas from the rodent and thus require a rather light lead shielding and allow operating very close by to the animal. The detectors, the front-end electronics (for signal preamplification, shaping, and discrimination) and the acquisition circuits are mounted on a single card. The device is connected directly to a portable computer via an USB port. Such a design provides a compact, rugged and portable device for working close to a small animal PET camera. Preliminary results show the performances of this counting system with 18F solution and a time-activity curve for FDG blood samples (with ∣˜30 μL/samples) from a rat.

Creating and Using a Camera Obscura

ERIC Educational Resources Information Center

Quinnell, Justin

2012-01-01

The camera obscura (Latin for "darkened room") is the earliest optical device and goes back over 2500 years. The small pinhole or lens at the front of the room allows light to enter and this is then "projected" onto a screen inside the room. This differs from a camera, which projects its image onto light-sensitive material.…

Explosive Transient Camera (ETC) Program

NASA Technical Reports Server (NTRS)

Ricker, George

1991-01-01

Since the inception of the ETC program, a wide range of new technologies was developed to support this astronomical instrument. The prototype unit was installed at ETC Site 1. The first partially automated observations were made and some major renovations were later added to the ETC hardware. The ETC was outfitted with new thermoelectrically-cooled CCD cameras and a sophisticated vacuum manifold, which, together, made the ETC a much more reliable unit than the prototype. The ETC instrumentation and building were placed under full computer control, allowing the ETC to operate as an automated, autonomous instrument with virtually no human intervention necessary. The first fully-automated operation of the ETC was performed, during which the ETC monitored the error region of the repeating soft gamma-ray burster SGR 1806-21.

ETR AND MTR COMPLEXES IN CONTEXT. CAMERA FACING NORTHERLY. FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ETR AND MTR COMPLEXES IN CONTEXT. CAMERA FACING NORTHERLY. FROM BOTTOM TO TOP: ETR COOLING TOWER, ELECTRICAL BUILDING AND LOW-BAY SECTION OF ETR BUILDING, HEAT EXCHANGER BUILDING (WITH U SHAPED YARD), COMPRESSOR BUILDING. MTR REACTOR SERVICES BUILDING IS ATTACHED TO SOUTH WALL OF MTR. WING A IS ATTACHED TO BALCONY FLOOR OF MTR. NEAR UPPER RIGHT CORNER OF VIEW IS MTR PROCESS WATER BUILDING. WING B IS AT FAR WEST END OF COMPLEX. NEAR MAIN GATE IS GAMMA FACILITY, WITH "COLD" BUILDINGS BEYOND: RAW WATER STORAGE TANKS, STEAM PLANT, MTR COOLING TOWER PUMP HOUSE AND COOLING TOWER. INL NEGATIVE NO. 56-4101. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Gamma-Ray Imaging Probes.

NASA Astrophysics Data System (ADS)

Wild, Walter James

1988-12-01

External nuclear medicine diagnostic imaging of early primary and metastatic lung cancer tumors is difficult due to the poor sensitivity and resolution of existing gamma cameras. Nonimaging counting detectors used for internal tumor detection give ambiguous results because distant background variations are difficult to discriminate from neighboring tumor sites. This suggests that an internal imaging nuclear medicine probe, particularly an esophageal probe, may be advantageously used to detect small tumors because of the ability to discriminate against background variations and the capability to get close to sites neighboring the esophagus. The design, theory of operation, preliminary bench tests, characterization of noise behavior and optimization of such an imaging probe is the central theme of this work. The central concept lies in the representation of the aperture shell by a sequence of binary digits. This, coupled with the mode of operation which is data encoding within an axial slice of space, leads to the fundamental imaging equation in which the coding operation is conveniently described by a circulant matrix operator. The coding/decoding process is a classic coded-aperture problem, and various estimators to achieve decoding are discussed. Some estimators require a priori information about the object (or object class) being imaged; the only unbiased estimator that does not impose this requirement is the simple inverse-matrix operator. The effects of noise on the estimate (or reconstruction) is discussed for general noise models and various codes/decoding operators. The choice of an optimal aperture for detector count times of clinical relevance is examined using a statistical class-separability formalism.

New Modular Camera No Ordinary Joe

NASA Technical Reports Server (NTRS)

2003-01-01

Although dubbed 'Little Joe' for its small-format characteristics, a new wavefront sensor camera has proved that it is far from coming up short when paired with high-speed, low-noise applications. SciMeasure Analytical Systems, Inc., a provider of cameras and imaging accessories for use in biomedical research and industrial inspection and quality control, is the eye behind Little Joe's shutter, manufacturing and selling the modular, multi-purpose camera worldwide to advance fields such as astronomy, neurobiology, and cardiology.

ARC-1986-A86-7011

NASA Image and Video Library

1986-01-14

Range : 2.52 million miles (1.56 million miles) P-29481B/W Voyager 2 returned this photograph with all nine known Uranus rings visible from a 15 sec. exposure through the narrow angle camera. The rings are quite dark and very narrow. The most prominent and outermost of the nine, Epsilon, is seen at top. The next three in toward Uranus, called Delta, Gamma, and Eta, are much fainter and more narrow than Epsilon ring. Then come Beta and Alpha rings, and finally, the innermost grouping, known simply as the 4,5, & 6 rings. The last three are very faint and are at the limit of detection for the Voyager camera. Uranus' rings range in width from about 100 km. (60 mi.) at the widest part of the Epsilon ring, to only a few kilometers for most of the others. this iamge was processed to enhance narrow features; the bright dots are imperfections on the camera detector. The resolution scale is about 50 km. (30 mi.)

Radiation Hardening of Digital Color CMOS Camera-on-a-Chip Building Blocks for Multi-MGy Total Ionizing Dose Environments

NASA Astrophysics Data System (ADS)

Goiffon, Vincent; Rolando, Sébastien; Corbière, Franck; Rizzolo, Serena; Chabane, Aziouz; Girard, Sylvain; Baer, Jérémy; Estribeau, Magali; Magnan, Pierre; Paillet, Philippe; Van Uffelen, Marco; Mont Casellas, Laura; Scott, Robin; Gaillardin, Marc; Marcandella, Claude; Marcelot, Olivier; Allanche, Timothé

2017-01-01

The Total Ionizing Dose (TID) hardness of digital color Camera-on-a-Chip (CoC) building blocks is explored in the Multi-MGy range using 60Co gamma-ray irradiations. The performances of the following CoC subcomponents are studied: radiation hardened (RH) pixel and photodiode designs, RH readout chain, Color Filter Arrays (CFA) and column RH Analog-to-Digital Converters (ADC). Several radiation hardness improvements are reported (on the readout chain and on dark current). CFAs and ADCs degradations appear to be very weak at the maximum TID of 6 MGy(SiO2), 600 Mrad. In the end, this study demonstrates the feasibility of a MGy rad-hard CMOS color digital camera-on-a-chip, illustrated by a color image captured after 6 MGy(SiO2) with no obvious degradation. An original dark current reduction mechanism in irradiated CMOS Image Sensors is also reported and discussed.

Mary, a Pipeline to Aid Discovery of Optical Transients

NASA Astrophysics Data System (ADS)

Andreoni, I.; Jacobs, C.; Hegarty, S.; Pritchard, T.; Cooke, J.; Ryder, S.

2017-09-01

The ability to quickly detect transient sources in optical images and trigger multi-wavelength follow up is key for the discovery of fast transients. These include events rare and difficult to detect such as kilonovae, supernova shock breakout, and `orphan' Gamma-ray Burst afterglows. We present the Mary pipeline, a (mostly) automated tool to discover transients during high-cadenced observations with the Dark Energy Camera at Cerro Tololo Inter-American Observatory (CTIO). The observations are part of the `Deeper Wider Faster' programme, a multi-facility, multi-wavelength programme designed to discover fast transients, including counterparts to Fast Radio Bursts and gravitational waves. Our tests of the Mary pipeline on Dark Energy Camera images return a false positive rate of 2.2% and a missed fraction of 3.4% obtained in less than 2 min, which proves the pipeline to be suitable for rapid and high-quality transient searches. The pipeline can be adapted to search for transients in data obtained with imagers other than Dark Energy Camera.

European team gauges a gamma-ray star

NASA Astrophysics Data System (ADS)

1996-03-01

Italian astrophysicists have pushed the Hubble Space Telescope to the limit of its powers in finding the distance of Geminga, a pointlike object 500 light-years from the Earth. It is the prototype of a novel kind of star, a radio-silent neutron star, which may be much more common in the Universe than previously supposed. Geminga is so weak in visible light that Hubble had to stare at the spot for more than an hour to register it adequately. The object is nevertheless one of the brightest sources of gamma-rays in the sky, and its output of this very energetic form of radiation can now be accurately ganged. Neutron stars, first discovered as radio pulsars in 1967, are fantastic creations of exploding stars, just one step short of a black hole. They are heavier than the Sun yet only about twenty kilometres wide. Made of compressed nuclear matter, they have gravity and magnetic fields many billions of times stronger than on the Earth. With the first direct measurement of the distance of a radio-silent neutron star, astrophysicists can assess Geminga's power and speed of motion. The astronomical task was like judging the width of a one- franc piece in Paris, seen from the distance of Sicily. Geminga's low brightness greatly aggravated the difficulties. Patrizia Caraveo and her colleagues at the Istituto di Fisica Cosmica in Milan arranged for Hubble's wide-field camera (WFPC2) to make its prolonged observations of Geminga three times. Their findings will be published in Astrophysical Journal Letters on 20 April 1996. Caraveo's co-authors are Giovanni Bignami and Roberto Mignani of Milan, and Laurence Taff of Johns Hopkins University, Maryland. The Italians took advantage of the European Space Agency's collaboration with NASA in the Hubble mission, which gives European astronomers privileged access to the Space Telescope. Shifts of millionths of a degree The three sightings of Geminga, made at intervals of six months, revealed small shifts in the position of the faint neutron star. The background of a few brighter but more distant stars displayed by Hubble's camera provided a frame of reference. In the course of a year, Geminga moved northeastwards by 0.17 arc-seconds, equivalent to one degree in 21,000 years. That was due to Geminga's high-speed motion through the Galaxy. But the neutron star also seemed to shift to either side of its interstellar track, because of changes in Hubble's viewpoint as the Earth orbited around the Sun. At opposite seasons, spring and autumn in this case, the Earth is on opposite sides of the Sun, at vantage points 300 million kilometres apart. As a result, the bearings of stars change a little, by the effect called parallax. Nearby stars shift more than very distant stars, and astronomers can measure their distances by trigonometry. The sideways displacement measured using the Hubble Space Telescope was 0.00636 arc-seconds, less than two millionths of a degree. From this figure the astronomers calculate that Geminga is 512 light-years away (157 parsecs) with an uncertainty of the order of 100 light-years. The strong gamma-rays and weak light observed today left Geminga around the time that Columbus discovered America. "We are pleased to have measured a parallax for an object at the limit of detection, which was never done before," says Patrizia Caraveo. "But what really matters is that we have pinned down an important object that has puzzled us for more than 20 years." From "it's not there" to "here it is" Geminga has tested the patience of the Milanese astronomers for twenty years. NASA's shortlived SAS-2 satellite (1973) first recorded a mysterious source of gamma-rays in the constellation of Gemini. In 1976 Giovanni Bignami named it Geminga. This is a pun signifying either "Gemini gamma" or "gh'è minga" which in the Milanese argot means "it's not there". Geminga lived up to its name when Bignami and his colleagues looked in vain for radio emissions from it. By 1981, data from ESA's longlived gamma-ray satellite COS-B had defined the position of the gamma-ray source to within half a degree -- well enough to prompt renewed efforts to identify it. Radio searches still drew a blank, but in the early 1980s Bignami and others found X-rays coming from Geminga in observations with NASA's Einstein satellite. They narrowed down Geminga's position to within a twentieth of a degree. There was no obvious counterpart to Geminga in visible light. Between 1983 and 1987 the Milanese team hunted for it with large telescopes in Hawaii and Chile. Eventually they selected a very faint object, peculiar in colour, as the visible Geminga. In 1992 a further sighting from Chile established Geminga's rate of movement across the sky. Meanwhile, the German/US/UK satellite Rosat revealed that Geminga pulsates in X-rays four times a second -- every 237 milliseconds to be precise. The same pulsation was found in gamma-rays by NASA's Gamma-Ray Observatory. Bignami and his colleagues then returned to the gamma-ray data from ESA's COS-B. They found the pulsation hidden there too and were able to compute the slowdown in Geminga's pulse-rate. From the slowdown they estimated the age of Geminga at 340,000 years. The distance measurement completes the gradual transformation of the enigmatic gamma-ray source into a well-characterized object. The Italian team calculates that Geminga is travelling at a speed of at least 120 kilometres per second. The neutron star's radiation in gamma-rays and X-rays is equivalent in energy to ten times the visible light of the Sun. More importantly, the way in which the neutron star distributes its energy output at different wavelengths is now known. "Neutron stars are radio sources for only a small fraction of their lives," says Giovanni Bignami. "So while we know 700 pulsars, there are probably millions of radio-silent neutron stars like Geminga. Thousands of them may be among X-ray sources already known but so far unidentified. I look forward to searching for new Gemingas with EPIC, our set of X-ray cameras in ESA's XMM satellite due for launch in 1999." The Hubble Space Telescope is a project of international cooperation between NASA and the European Space Agency (ESA). The Space Telescope Science Institute is operated by the Association of Universities for Research in Astronomy, Inc. (AURA), for NASA, under contract with the Goddard Space Flight Center, Greenbelt, MD. Patrizia A. Caraveo - Istituto di Fisica Cosmica del CNR, Via Bass 20133 - MILANO (Italy) Giovanni F. Bignami - Istituto di Fisica Cosmica del CNR, Via Bass - 20133-MILANO (Italy) Dipartimento di Ingegneria Industriale, Univ. of Cassino, CASSINO, Roberto Mignani - Istituto di Fisica Cosmica del CNR, Via Bassini, 20133-MILANO (Italy) Universita di Milano, Italy Laurence G. Taff - Department of Physics and Astronomy, JHU, BALTIMORE (MD Research Supported in part by General Observer Grant GO 5484.01-93

Using triple gamma coincidences with a pixelated semiconductor Compton-PET scanner: a simulation study

NASA Astrophysics Data System (ADS)

Kolstein, M.; Chmeissani, M.

2016-01-01

The Voxel Imaging PET (VIP) Pathfinder project presents a novel design using pixelated semiconductor detectors for nuclear medicine applications to achieve the intrinsic image quality limits set by physics. The conceptual design can be extended to a Compton gamma camera. The use of a pixelated CdTe detector with voxel sizes of 1 × 1 × 2 mm3 guarantees optimal energy and spatial resolution. However, the limited time resolution of semiconductor detectors makes it impossible to use Time Of Flight (TOF) with VIP PET. TOF is used in order to improve the signal to noise ratio (SNR) by using only the most probable portion of the Line-Of-Response (LOR) instead of its entire length. To overcome the limitation of CdTe time resolution, we present in this article a simulation study using β+-γ emitting isotopes with a Compton-PET scanner. When the β+ annihilates with an electron it produces two gammas which produce a LOR in the PET scanner, while the additional gamma, when scattered in the scatter detector, provides a Compton cone that intersects with the aforementioned LOR. The intersection indicates, within a few mm of uncertainty along the LOR, the origin of the beta-gamma decay. Hence, one can limit the part of the LOR used by the image reconstruction algorithm.

Performance of the Gamma-ray Cherenkov Telescope structure: a dual-mirror telescope prototype proposed for the future Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Dournaux, J. L.; Amans, J. P.; Dangeon, L.; Fasola, G.; Gironnet, J.; Huet, J. M.; Laporte, P.; Abchiche, A.; Barkaoui, S.; Bousquet, J. J.; Buchholtz, G.; Dumas, D.; Gaudemard, J.; Jégouzo, I.; Poinsignon, P.; Vergne, L.; Sol, H.

2016-07-01

The Cherenkov Telescope Array (CTA) project aims to create the next generation Very High-Energy (VHE) gamma-ray telescope array. It will be devoted to the observation of gamma rays from 20 GeV to above 100 TeV. Because of this wide energy band, three classes of telescopes, associated with different energy ranges and different mirror sizes, are defined. The Small Size Telescopes (SSTs) are associated with the highest energy range. Seventy of these telescopes are foreseen on the Southern site of the CTA. The large number of telescopes constrains their mechanical structure because easy maintenance and reduced cost per telescope are needed. Moreover, of course, the design shall fulfill the required performance and lifetime in the environment conditions of the site. The Observatoire de Paris started design studies in 2011 of the mechanical structure of the GCT (Gamma-ray Cherenkov Telescope), a four-meter prototype telescope for the SSTs of CTA, from optical and preliminary mechanical designs made by the University of Durham. At the end of 2014 these studies finally resulted in a lightweight ( 8 tons) and stiff design. This structure was based on the dual-mirror Schwarzschild-Couder (SC) optical design, which is an interesting and innovative alternative to the one-mirror Davies-Cotton design commonly used in ground-based Cherenkov astronomy. The benefits of such a design are many since it enables a compact structure, lightweight camera and a good angular resolution across the entire field-of-view. The mechanical structure was assembled on the Meudon site of the Observatoire de Paris in spring 2015. The secondary mirror, panels of the primary mirror and the Telescope Control System were successfully implemented afterwards leading now to a fully operational telescope. This paper focuses on the mechanics of the telescope prototype. It describes the mechanical structure and presents its performance identified from computations or direct measurements. Upgrades of the design in the context of the preproduction and the large scale CTA production are also discussed.

Small real time detection satellites for MDA using hyperspectral imaging

NASA Astrophysics Data System (ADS)

Nakaya, Daiki; Yanagida, Hiroki; Shin, Satori; Ito, Tomonori; Takeuchi, Yusuke

2017-10-01

Hyperspectral Images are now used in the field of agriculture, cosmetics, and space exploring. Behind this fact, there is a result of efforts to contrive miniaturization and decrease in costs. This paper describes low-cost and small Hyperspectral Camera (HSC) under development and a method of utilizing it. Real Time Detection System for MDA is that government agencies put those cameras in small satellites and use them for MDA (Maritime Domain Awareness). We assume early detection of unidentified floating objects to find out disguised fishing ships and submarines.

Prototypic Development and Evaluation of a Medium Format Metric Camera

NASA Astrophysics Data System (ADS)

Hastedt, H.; Rofallski, R.; Luhmann, T.; Rosenbauer, R.; Ochsner, D.; Rieke-Zapp, D.

2018-05-01

Engineering applications require high-precision 3D measurement techniques for object sizes that vary between small volumes (2-3 m in each direction) and large volumes (around 20 x 20 x 1-10 m). The requested precision in object space (1σ RMS) is defined to be within 0.1-0.2 mm for large volumes and less than 0.01 mm for small volumes. In particular, focussing large volume applications the availability of a metric camera would have different advantages for several reasons: 1) high-quality optical components and stabilisations allow for a stable interior geometry of the camera itself, 2) a stable geometry leads to a stable interior orientation that enables for an a priori camera calibration, 3) a higher resulting precision can be expected. With this article the development and accuracy evaluation of a new metric camera, the ALPA 12 FPS add|metric will be presented. Its general accuracy potential is tested against calibrated lengths in a small volume test environment based on the German Guideline VDI/VDE 2634.1 (2002). Maximum length measurement errors of less than 0.025 mm are achieved with different scenarios having been tested. The accuracy potential for large volumes is estimated within a feasibility study on the application of photogrammetric measurements for the deformation estimation on a large wooden shipwreck in the German Maritime Museum. An accuracy of 0.2 mm-0.4 mm is reached for a length of 28 m (given by a distance from a lasertracker network measurement). All analyses have proven high stabilities of the interior orientation of the camera and indicate the applicability for a priori camera calibration for subsequent 3D measurements.

The scintigraphic determination of small intestinal transit time in patients with irritable bowel syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marano, A.R.; Caride, V.J.; Shah, R.V.

1984-01-01

Diffuse disturbance in gastrointestinal motility may be present in patients with irritable bowel syndrome (IBS). To further investigate small intestinal motility in IBS patients small intestinal transit time (SITT) was determined and related to the symptom status. 11 female patients with IBS (mean age 29 years) were divided into those whose predominate symptom was diarrhea (N=6), and those with only constipation (N=5). All subjects ingested an isosmotic solution of lactulose (10 gm in 150cc of water) labeled with 99m-Tc-DTPA (Sn). The patient was studied supine under a 25 inch gamma camera with data collected at 1 frame per minute formore » 180 minutes or until activity appeared in the ascending colon. Regions of interest were selected over the cecum and ascending colon. The time of first appearance of radioactivity in the region of the cecum was taken as the small intestinal transit time. SITT in the 5 normal females was 98.7 +- 13 min (mean +- SEM). SITT in the IBS patients with diarrhea, 67.3 +- 7 min was significantly faster (p< 0.08). SITT in the constipated IBS patients, 126 +- 12 min, was slower than normals and significantly different from diarrhea patients (p< 0.001). These studies show that IBS patients with diarrhea have significantly faster SITT than normals while constipated IBS patients have significantly slower SITT than the diarrhea subgroup. Further, this study emphasizes the need to study the various symptomatic subgroups of IBs patients independently and indicates a possible role for abnormal SITT in the pathogenesis of IBS.« less

Photon counting readout pixel array in 0.18-μm CMOS technology for on-line gamma-ray imaging of 103palladium seeds for permanent breast seed implant (PBSI) brachytherapy

NASA Astrophysics Data System (ADS)

Goldan, A. H.; Karim, K. S.; Reznik, A.; Caldwell, C. B.; Rowlands, J. A.

2008-03-01

Permanent breast seed implant (PBSI) brachytherapy technique was recently introduced as an alternative to high dose rate (HDR) brachytherapy and involves the permanent implantation of radioactive 103Palladium seeds into the surgical cavity of the breast for cancer treatment. To enable accurate seed implantation, this research introduces a gamma camera based on a hybrid amorphous selenium detector and CMOS readout pixel architecture for real-time imaging of 103Palladium seeds during the PBSI procedure. A prototype chip was designed and fabricated in 0.18-μm n-well CMOS process. We present the experimental results obtained from this integrated photon counting readout pixel.

A comprehensive experimental characterization of the iPIX gamma imager

NASA Astrophysics Data System (ADS)

Amgarou, K.; Paradiso, V.; Patoz, A.; Bonnet, F.; Handley, J.; Couturier, P.; Becker, F.; Menaa, N.

2016-08-01

The results of more than 280 different experiments aimed at exploring the main features and performances of a newly developed gamma imager, called iPIX, are summarized in this paper. iPIX is designed to quickly localize radioactive sources while estimating the ambient dose equivalent rate at the measurement point. It integrates a 1 mm thick CdTe detector directly bump-bonded to a Timepix chip, a tungsten coded-aperture mask, and a mini RGB camera. It also represents a major technological breakthrough in terms of lightness, compactness, usability, response sensitivity, and angular resolution. As an example of its key strengths, an 241Am source with a dose rate of only few nSv/h can be localized in less than one minute.

Search of the energetic gamma-ray experiment telescope (EGRET) data for high-energy gamma-ray microsecond bursts

NASA Technical Reports Server (NTRS)

Fichtel, C. E.; Bertsch, D. L.; Dingus, B. L.; Esposito, J. A.; Hartman, R. C.; Hunter, S. D.; Kanbach, G.; Kniffen, D. A.; Lin, Y. C.; Mattox, J. R.

1994-01-01

Hawking (1974) and Page & Hawking (1976) investigated theoretically the possibility of detecting high-energy gamma rays produced by the quantum-mechanical decay of a small black hole created in the early universe. They concluded that, at the very end of the life of the small black hole, it would radiate a burst of gamma rays peaked near 250 MeV with a total energy of about 10(exp 34) ergs in the order of a microsecond or less. The characteristics of a black hole are determined by laws of physics beyond the range of current particle accelerators; hence, the search for these short bursts of high-energy gamma rays provides at least the possibility of being the first test of this region of physics. The Compton Observatory Energetic Gamma-Ray Experiment Telescope (EGRET) has the capability of detecting directly the gamma rays from such bursts at a much fainter level than SAS 2, and a search of the EGRET data has led to an upper limit of 5 x 10(exp -2) black hole decays per cu pc per yr, placing constraints on this and other theories predicting microsecond high-energy gamma-ray bursts.

Spectral analysis method for detecting an element

DOEpatents

Blackwood, Larry G [Idaho Falls, ID; Edwards, Andrew J [Idaho Falls, ID; Jewell, James K [Idaho Falls, ID; Reber, Edward L [Idaho Falls, ID; Seabury, Edward H [Idaho Falls, ID

2008-02-12

A method for detecting an element is described and which includes the steps of providing a gamma-ray spectrum which has a region of interest which corresponds with a small amount of an element to be detected; providing nonparametric assumptions about a shape of the gamma-ray spectrum in the region of interest, and which would indicate the presence of the element to be detected; and applying a statistical test to the shape of the gamma-ray spectrum based upon the nonparametric assumptions to detect the small amount of the element to be detected.

Instant Video Revisiting: The Video Camera as a "Tool of the Mind" for Young Children.

ERIC Educational Resources Information Center

Forman, George

1999-01-01

Once used only to record special events in the classroom, video cameras are now small enough and affordable enough to be used to document everyday events. Video cameras, with foldout screens, allow children to watch their activities immediately after they happen and to discuss them with a teacher. This article coins the term instant video…

A calibration method based on virtual large planar target for cameras with large FOV

NASA Astrophysics Data System (ADS)

Yu, Lei; Han, Yangyang; Nie, Hong; Ou, Qiaofeng; Xiong, Bangshu

2018-02-01

In order to obtain high precision in camera calibration, a target should be large enough to cover the whole field of view (FOV). For cameras with large FOV, using a small target will seriously reduce the precision of calibration. However, using a large target causes many difficulties in making, carrying and employing the large target. In order to solve this problem, a calibration method based on the virtual large planar target (VLPT), which is virtually constructed with multiple small targets (STs), is proposed for cameras with large FOV. In the VLPT-based calibration method, first, the positions and directions of STs are changed several times to obtain a number of calibration images. Secondly, the VLPT of each calibration image is created by finding the virtual point corresponding to the feature points of the STs. Finally, intrinsic and extrinsic parameters of the camera are calculated by using the VLPTs. Experiment results show that the proposed method can not only achieve the similar calibration precision as those employing a large target, but also have good stability in the whole measurement area. Thus, the difficulties to accurately calibrate cameras with large FOV can be perfectly tackled by the proposed method with good operability.

A customizable commercial miniaturized 320×256 indium gallium arsenide shortwave infrared camera

NASA Astrophysics Data System (ADS)

Huang, Shih-Che; O'Grady, Matthew; Groppe, Joseph V.; Ettenberg, Martin H.; Brubaker, Robert M.

2004-10-01

The design and performance of a commercial short-wave-infrared (SWIR) InGaAs microcamera engine is presented. The 0.9-to-1.7 micron SWIR imaging system consists of a room-temperature-TEC-stabilized, 320x256 (25 μm pitch) InGaAs focal plane array (FPA) and a high-performance, highly customizable image-processing set of electronics. The detectivity, D*, of the system is greater than 1013 cm-√Hz/W at 1.55 μm, and this sensitivity may be adjusted in real-time over 100 dB. It features snapshot-mode integration with a minimum exposure time of 130 μs. The digital video processor provides real time pixel-to-pixel, 2-point dark-current subtraction and non-uniformity compensation along with defective-pixel substitution. Other features include automatic gain control (AGC), gamma correction, 7 preset configurations, adjustable exposure time, external triggering, and windowing. The windowing feature is highly flexible; the region of interest (ROI) may be placed anywhere on the imager and can be varied at will. Windowing allows for high-speed readout enabling such applications as target acquisition and tracking; for example, a 32x32 ROI window may be read out at over 3500 frames per second (fps). Output video is provided as EIA170-compatible analog, or as 12-bit CameraLink-compatible digital. All the above features are accomplished in a small volume < 28 cm3, weight < 70 g, and with low power consumption < 1.3 W at room temperature using this new microcamera engine. Video processing is based on a field-programmable gate array (FPGA) platform with a soft-embedded processor that allows for ease of integration/addition of customer-specific algorithms, processes, or design requirements. The camera was developed with the high-performance, space-restricted, power-conscious application in mind, such as robotic or UAV deployment.

SU-F-BRE-07: Experimental Validation of a Lung SBRT Technique Using a Novel, True Volumetric Plenoptic-Plastic-Scintillator Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goulet, M; Rilling, M; Gingras, L

2014-06-15

Purpose: Lung SBRT is being used by an increasing number of clinics, including our center which recently treated its first patient. In order to validate this technique, the 3D dose distribution of the SBRT plan was measured using a previously developed 3D detector based on plenoptic camera and plastic scintillator technology. The excellent agreement between the detector measurement and the expected dose from the treatment planning system Pinnacle{sup 3} shows great promise and amply justify the development of the technique. Methods: The SBRT treatment comprised 8 non-coplanar 6MV photon fields with a mean field size of 12 cm{sup 2} atmore » isocentre and a total prescription dose of 12Gy per fraction for a total of 48Gy. The 3D detector was composed of a 10×10×10 cm{sup 2} EJ-260 water-equivalent plastic scintillator embedded inside a truncated cylindrical acrylic phantom of 10cm radius. The scintillation light was recorded using a static R5 light-field camera and the 3D dose was reconstructed at a 2mm resolution in all 3 dimensions using an iterative backprojection algorithm. Results: The whole 3D dose distribution was recorded at a rate of one acquisition per second. The mean absolute dose difference between the detector and Pinnacle{sup 3} was 1.3% over the region with more than 10% of the maximum dose. 3D gamma tests performed over the same region yield passing rates of 98.8% and 96.6% with criteria of 3%/1mm and 2%/1mm, respectively. Conclusion: Experimental results showed that our beam modeling and treatment planning system calculation was adequate for the safe administration of small field/high dose techniques such as SBRT. Moreover, because of the real-time capability of the detector, further validation of small field rotational, dynamic or gated technique can be monitored or verified by this system.« less

Compton Camera and Prompt Gamma Ray Timing: Two Methods for In Vivo Range Assessment in Proton Therapy

PubMed Central

Hueso-González, Fernando; Fiedler, Fine; Golnik, Christian; Kormoll, Thomas; Pausch, Guntram; Petzoldt, Johannes; Römer, Katja E.; Enghardt, Wolfgang

2016-01-01

Proton beams are promising means for treating tumors. Such charged particles stop at a defined depth, where the ionization density is maximum. As the dose deposit beyond this distal edge is very low, proton therapy minimizes the damage to normal tissue compared to photon therapy. Nevertheless, inherent range uncertainties cast doubts on the irradiation of tumors close to organs at risk and lead to the application of conservative safety margins. This constrains significantly the potential benefits of protons over photons. In this context, several research groups are developing experimental tools for range verification based on the detection of prompt gammas, a nuclear by-product of the proton irradiation. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf, detector components have been characterized in realistic radiation environments as a step toward a clinical Compton camera. On the one hand, corresponding experimental methods and results obtained during the ENTERVISION training network are reviewed. On the other hand, a novel method based on timing spectroscopy has been proposed as an alternative to collimated imaging systems. The first tests of the timing method at a clinical proton accelerator are summarized, its applicability in a clinical environment for challenging the current safety margins is assessed, and the factors limiting its precision are discussed. PMID:27148473

Optical artefact characterization and correction in volumetric scintillation dosimetry

PubMed Central

Robertson, Daniel; Hui, Cheukkai; Archambault, Louis; Mohan, Radhe; Beddar, Sam

2014-01-01

The goals of this study were (1) to characterize the optical artefacts affecting measurement accuracy in a volumetric liquid scintillation detector, and (2) to develop methods to correct for these artefacts. The optical artefacts addressed were photon scattering, refraction, camera perspective, vignetting, lens distortion, the lens point spread function, stray radiation, and noise in the camera. These artefacts were evaluated by theoretical and experimental means, and specific correction strategies were developed for each artefact. The effectiveness of the correction methods was evaluated by comparing raw and corrected images of the scintillation light from proton pencil beams against validated Monte Carlo calculations. Blurring due to the lens and refraction at the scintillator tank-air interface were found to have the largest effect on the measured light distribution, and lens aberrations and vignetting were important primarily at the image edges. Photon scatter in the scintillator was not found to be a significant source of artefacts. The correction methods effectively mitigated the artefacts, increasing the average gamma analysis pass rate from 66% to 98% for gamma criteria of 2% dose difference and 2 mm distance to agreement. We conclude that optical artefacts cause clinically meaningful errors in the measured light distribution, and we have demonstrated effective strategies for correcting these optical artefacts. PMID:24321820

New camera-based microswitch technology to monitor small head and mouth responses of children with multiple disabilities.

PubMed

Lancioni, Giulio E; Bellini, Domenico; Oliva, Doretta; Singh, Nirbhay N; O'Reilly, Mark F; Green, Vanessa A; Furniss, Fred

2014-06-01

Assessing a new camera-based microswitch technology, which did not require the use of color marks on the participants' face. Two children with extensive multiple disabilities participated. The responses selected for them consisted of small, lateral head movements and mouth closing or opening. The intervention was carried out according to a multiple probe design across responses. The technology involved a computer with a CPU using a 2-GHz clock, a USB video camera with a 16-mm lens, a USB cable connecting the camera and the computer, and a special software program written in ISO C++ language. The new technology was satisfactorily used with both children. Large increases in their responding were observed during the intervention periods (i.e. when the responses were followed by preferred stimulation). The new technology may be an important resource for persons with multiple disabilities and minimal motor behavior.

Product Plan of New Generation System Camera "OLYMPUS PEN E-P1"

NASA Astrophysics Data System (ADS)

Ogawa, Haruo

"OLYMPUS PEN E-P1", which is new generation system camera, is the first product of Olympus which is new standard "Micro Four-thirds System" for high-resolution mirror-less cameras. It continues good sales by the concept of "small and stylish design, easy operation and SLR image quality" since release on July 3, 2009. On the other hand, the half-size film camera "OLYMPUS PEN" was popular by the concept "small and stylish design and original mechanism" since the first product in 1959 and recorded sale number more than 17 million with 17 models. By the 50th anniversary topic and emotional value of the Olympus pen, Olympus pen E-P1 became big sales. I would like to explain the way of thinking of the product plan that included not only the simple functional value but also emotional value on planning the first product of "Micro Four-thirds System".

Development of a 32-detector CdTe matrix for the SVOM ECLAIRs x/gamma camera: tests results of first flight models

NASA Astrophysics Data System (ADS)

Lacombe, K.; Dezalay, J.-P.; Houret, B.; Amoros, C.; Atteia, J.-L.; Aubaret, K.; Billot, M.; Bordon, S.; Cordier, B.; Delaigue, S.; Galliano, M.; Gevin, O.; Godet, O.; Gonzalez, F.; Guillemot, Ph.; Limousin, O.; Mercier, K.; Nasser, G.; Pons, R.; Rambaud, D.; Ramon, P.; Waegebaert, V.

2016-07-01

ECLAIRs, a 2-D coded-mask imaging camera on-board the Sino-French SVOM space mission, will detect and locate gamma-ray bursts in near real time in the 4 - 150 keV energy band in a large field of view. The design of ECLAIRs has been driven by the objective to reach an unprecedented low-energy threshold of 4 keV. The detection plane is an assembly of 6400 Schottky CdTe detectors of size 4x4x1 mm3, biased from -200V to -500V and operated at -20°C. The low-energy threshold is achieved thanks to an innovative hybrid module composed of a thick film ceramic holding 32 CdTe detectors ("Detectors Ceramics"), associated to an HTCC ceramic housing a low-noise 32-channel ASIC ("ASIC Ceramics"). We manage the coupling between Detectors Ceramics and ASIC Ceramics in order to achieve the best performance and ensure the uniformity of the detection plane. In this paper, we describe the complete hybrid XRDPIX, of which 50 flight models have been manufactured by the SAGEM company. Afterwards, we show test results obtained on Detectors Ceramics, on ASIC Ceramics and on the modules once assembled. Then, we compare and confront detectors leakage currents and ASIC ENC with the energy threshold values and FWHM measured on XRDPIX modules at the temperature of -20°C by using a calibrated radioactive source of 241Am. Finally, we study the homogeneity of the spectral properties of the 32-detector hybrid matrices and we conclude on general performance of more than 1000 detection channels which may reach the lowenergy threshold of 4 keV required for the future ECLAIRs space camera.

Study on the Spatial Resolution of Single and Multiple Coincidences Compton Camera

NASA Astrophysics Data System (ADS)

Andreyev, Andriy; Sitek, Arkadiusz; Celler, Anna

2012-10-01

In this paper we study the image resolution that can be obtained from the Multiple Coincidences Compton Camera (MCCC). The principle of MCCC is based on a simultaneous acquisition of several gamma-rays emitted in cascade from a single nucleus. Contrary to a standard Compton camera, MCCC can theoretically provide the exact location of a radioactive source (based only on the identification of the intersection point of three cones created by a single decay), without complicated tomographic reconstruction. However, practical implementation of the MCCC approach encounters several problems, such as low detection sensitivities result in very low probability of coincident triple gamma-ray detection, which is necessary for the source localization. It is also important to evaluate how the detection uncertainties (finite energy and spatial resolution) influence identification of the intersection of three cones, thus the resulting image quality. In this study we investigate how the spatial resolution of the reconstructed images using the triple-cone reconstruction (TCR) approach compares to images reconstructed from the same data using standard iterative method based on single-cone. Results show, that FWHM for the point source reconstructed with TCR was 20-30% higher than the one obtained from the standard iterative reconstruction based on expectation maximization (EM) algorithm and conventional single-cone Compton imaging. Finite energy and spatial resolutions of the MCCC detectors lead to errors in conical surfaces definitions (“thick” conical surfaces) which only amplify in image reconstruction when intersection of three cones is being sought. Our investigations show that, in spite of being conceptually appealing, the identification of triple cone intersection constitutes yet another restriction of the multiple coincidence approach which limits the image resolution that can be obtained with MCCC and TCR algorithm.

Applications of Action Cam Sensors in the Archaeological Yard

NASA Astrophysics Data System (ADS)

Pepe, M.; Ackermann, S.; Fregonese, L.; Fassi, F.; Adami, A.

2018-05-01

In recent years, special digital cameras called "action camera" or "action cam", have become popular due to their low price, smallness, lightness, strength and capacity to make videos and photos even in extreme environment surrounding condition. Indeed, these particular cameras have been designed mainly to capture sport actions and work even in case of dirt, bumps, or underwater and at different external temperatures. High resolution of Digital single-lens reflex (DSLR) cameras are usually preferred to be employed in photogrammetric field. Indeed, beyond the sensor resolution, the combination of such cameras with fixed lens with low distortion are preferred to perform accurate 3D measurements; at the contrary, action cameras have small and wide-angle lens, with a lower performance in terms of sensor resolution, lens quality and distortions. However, by considering the characteristics of the action cameras to acquire under conditions that may result difficult for standard DSLR cameras and because of their lower price, these could be taken into consideration as a possible and interesting approach during archaeological excavation activities to document the state of the places. In this paper, the influence of lens radial distortion and chromatic aberration on this type of cameras in self-calibration mode and an evaluation of their application in the field of Cultural Heritage will be investigated and discussed. Using a suitable technique, it has been possible to improve the accuracy of the 3D model obtained by action cam images. Case studies show the quality and the utility of the use of this type of sensor in the survey of archaeological artefacts.

Measurement of the ambient gamma dose equivalent and kerma from the small 252Cf source at 1 meter and the small 60Co source at 2 meters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carl, W. F.

NASA Langley Research Center requested a measurement and determination of the ambient gamma dose equivalent rate and kerma at 100 cm from the 252Cf source and determination of the ambient gamma dose equivalent rate and kerma at 200 cm from the 60Co source for the Radiation Budget Instrument Experiment (Rad-X). An Exradin A6 ion chamber with Shonka air-equivalent plastic walls in combination with a Supermax electrometer were used to measure the exposure rate and free-in-air kerma rate of the two sources at the requested distances. The measured gamma exposure, kerma, and dose equivalent rates are tabulated.

Nuclear Radiation Degradation Study on HD Camera Based on CMOS Image Sensor at Different Dose Rates.

PubMed

Wang, Congzheng; Hu, Song; Gao, Chunming; Feng, Chang

2018-02-08

In this work, we irradiated a high-definition (HD) industrial camera based on a commercial-off-the-shelf (COTS) CMOS image sensor (CIS) with Cobalt-60 gamma-rays. All components of the camera under test were fabricated without radiation hardening, except for the lens. The irradiation experiments of the HD camera under biased conditions were carried out at 1.0, 10.0, 20.0, 50.0 and 100.0 Gy/h. During the experiment, we found that the tested camera showed a remarkable degradation after irradiation and differed in the dose rates. With the increase of dose rate, the same target images become brighter. Under the same dose rate, the radiation effect in bright area is lower than that in dark area. Under different dose rates, the higher the dose rate is, the worse the radiation effect will be in both bright and dark areas. And the standard deviations of bright and dark areas become greater. Furthermore, through the progressive degradation analysis of the captured image, experimental results demonstrate that the attenuation of signal to noise ratio (SNR) versus radiation time is not obvious at the same dose rate, and the degradation is more and more serious with increasing dose rate. Additionally, the decrease rate of SNR at 20.0, 50.0 and 100.0 Gy/h is far greater than that at 1.0 and 10.0 Gy/h. Even so, we confirm that the HD industrial camera is still working at 10.0 Gy/h during the 8 h of measurements, with a moderate decrease of the SNR (5 dB). The work is valuable and can provide suggestion for camera users in the radiation field.

Routine 18F-2-deoxy-2-fluoro-D-glucose (18F-FDG) myocardial tomography using a normal large field of view gamma-camera.

PubMed

Höflin, F; Ledermann, H; Noelpp, U; Weinreich, R; Rösler, H

1989-12-01

There is a recent need to study glucose metabolism of the heart in ischemic, as well as in "hibernating or stunned" myocardium, and compare it with that in perfusion studies. In non-positron emission tomography centers, positron imaging is possible with a standard Anger-type camera if proper collimation and adequate shielding of the camera crystal can be achieved. For the study with fast-decaying isotopes, seven-pinhole tomography (7PHT), a limited-angle method designed for transaxial tomography of the left ventricle using a nonrotating camera, is well suited, because projections are acquired simultaneously. Individual adjustment (patient supine) of the camera's view axis (CAx) with the left ventricular axis (LVAx) gives excellent results: sensitivity for CHD 82%, specificity 72% in a prospective 201TI study (48 patients, x-ray coronarography as reference). Good alignment of CAx with LVAx is also achieved with the patient prone in LAO in a hammock above the camera surface. In this setting additional lead shielding of the camera is possible using a table reinforced with 5 cm of lead with a central hole for the 7PH-collimator, which has a special lead inlay. This allows utilization of the 511 KeV emitter 18F-FDG, which with a half-life of 109 minutes, can be transported a reasonable distance from the production site. System sensitivity and resolution for 18F was found comparable to 201Tl, 99mTc, and 123I using a phantom. First clinical examinations after 201Tl stress/redistribution studies showed increased 18F-FDG uptake in ischemic heart segments, as well as in "hibernating" nonperfused or "stunned" myocardium.

Nuclear Radiation Degradation Study on HD Camera Based on CMOS Image Sensor at Different Dose Rates

PubMed Central

Wang, Congzheng; Hu, Song; Gao, Chunming; Feng, Chang

2018-01-01

In this work, we irradiated a high-definition (HD) industrial camera based on a commercial-off-the-shelf (COTS) CMOS image sensor (CIS) with Cobalt-60 gamma-rays. All components of the camera under test were fabricated without radiation hardening, except for the lens. The irradiation experiments of the HD camera under biased conditions were carried out at 1.0, 10.0, 20.0, 50.0 and 100.0 Gy/h. During the experiment, we found that the tested camera showed a remarkable degradation after irradiation and differed in the dose rates. With the increase of dose rate, the same target images become brighter. Under the same dose rate, the radiation effect in bright area is lower than that in dark area. Under different dose rates, the higher the dose rate is, the worse the radiation effect will be in both bright and dark areas. And the standard deviations of bright and dark areas become greater. Furthermore, through the progressive degradation analysis of the captured image, experimental results demonstrate that the attenuation of signal to noise ratio (SNR) versus radiation time is not obvious at the same dose rate, and the degradation is more and more serious with increasing dose rate. Additionally, the decrease rate of SNR at 20.0, 50.0 and 100.0 Gy/h is far greater than that at 1.0 and 10.0 Gy/h. Even so, we confirm that the HD industrial camera is still working at 10.0 Gy/h during the 8 h of measurements, with a moderate decrease of the SNR (5 dB). The work is valuable and can provide suggestion for camera users in the radiation field. PMID:29419782

Overview of MAGIC results

NASA Astrophysics Data System (ADS)

Rico, Javier; MAGIC Collaboration

2016-04-01

MAGIC is a system of two 17-m diameter Cherenkov telescopes, located at the Observatorio del Roque de los Muchachos, in the Canary island La Palma (Spain). MAGIC performs astronomical observations of gamma-ray sources in the energy range between 50 GeV and 10 TeV. The first MAGIC telescope has been operating since 2004, and in 2009 the system was completed with the second one. During 2011 and 2012 the electronics for the readout system were fully upgraded, and the camera of the first telescope replaced. After that, no major hardware interventions are foreseen in the next years, and the experiment has undertaken a final period of steady astronomical observations. MAGIC studies particle acceleration in the most violent cosmic environments, such as active galactic nuclei, gamma-ray bursts, pulsars, supernova remnants or binary systems. In addition, it addresses some fundamental questions of Physics, such as the origin of Galactic cosmic rays and the nature of dark matter. Moreover, by observing the gamma-ray emission from sources at cosmological distances, we measure the intensity and evolution of the extragalactic background radiation, and perform tests of Lorentz Invariance. In this paper I present the status and some of the latest results of the MAGIC gamma-ray telescopes.

Gamma-ray detectors for breast imaging

NASA Astrophysics Data System (ADS)

Williams, Mark B.; Goode, Allen R.; Majewski, Stan; Steinbach, Daniela; Weisenberger, Andrew G.; Wojcik, Randolph F.; Farzanpay, Farzin

1997-07-01

Breast cancer is the most common cancer of American women and is the leading cause of cancer-related death among women aged 15 - 54; however recent years have shown that early detection using x-ray mammography can lead to a high probability of cure. However, because of mammography's low positive predictive value, surgical or core biopsy is typically required for diagnosis. In addition, the low radiographic contrast of many nonpalpable breast masses, particularly among women with radiographically dense breasts, results in an overall rate of 10% to 25% for missed tumors. Nuclear imaging of the breast using single gamma emitters (scintimammography) such as (superscript 99m)Tc, or positron emitters such as F-18- fluorodeoxyglucose (FDG) for positron emission tomography (PET), can provide information on functional or metabolic tumor activity that is complementary to the structural information of x-ray mammography, thereby potentially reducing the number of unnecessary biopsies and missed cancers. This paper summarizes recent data on the efficacy of scintimammography using conventional gamma cameras, and describes the development of dedicated detectors for gamma emission breast imaging. The detectors use new, high density crystal scintillators and large area position sensitive photomultiplier tubes (PSPMTs). Detector design, imaging requirements, and preliminary measured imaging performance are discussed.

Accelerated aging, natural aging, and small punch testing of gamma-air sterilized polycarbonate urethane acetabular components.

PubMed

Kurtz, S M; Siskey, R; Reitman, M

2010-05-01

The objectives of this study were three-fold: (1) to determine the applicability of the small punch test to characterize Bionate 80A polycarbonate urethane (PCU) acetabular implants; (2) to evaluate the susceptibility of PCU acetabular implants to exhibit degradation of mechanical behavior following gamma irradiation in air and accelerated aging; and (3) to compare the oxidation of gamma-air sterilized PCU following accelerated aging and 5 years of natural shelf aging. In addition to attenuated total reflectance-Fourier transform infrared spectroscopy, we also adapted a miniature specimen mechanical test, the small punch test, for the deformable PCU cups. Accelerated aging was performed using ASTM F2003, a standard test that represents a severe oxidative challenge. The results of this study suggest that the small punch test is sufficiently sensitive and reproducible to discriminate slight differences in the large-deformation mechanical behavior of Bionate 80A following accelerated aging. The gamma-air sterilized PCU had a reduction of 9% in ultimate load after aging. Five years of shelf aging had little effect on the mechanical properties of the PCU. Overall, our findings suggest that the Bionate 80A material has greater oxidative stability than ultra-high molecular weight polyethylene following gamma irradiation in air and exposure to a severe oxidative challenge. (c) 2010 Wiley Periodicals, Inc.

Selenium homocholic acid taurocholate scanning, selenium-75-labeled bile acid, a novel method for testing the function of the terminal ileum in small bowel transplant recipients: a pilot study.

PubMed

Beath, S V; Lanchbury, E; Alton, H; Mahandru, R; Toy, M; van Mouirk, I D; McKiernan, P J; Hartley, J; Kelly, D A; Sharif, K; Gupte, G

2014-01-01

The terminal ileum (TI) is important for the active reabsorption of bile salts and is the site of allograft rejection; disruption of enterohepatic circulation (EHC) may give insights to inflammatory and other physiologic processes at the TI. Four children aged 5 to 12 years who had received small bowel transplantation (SBTx), 3 recovering from post-transplant lymphoproliferative disease (PTLD) and 1 with acute rejection, were studied. Two of the 4 had stoma reversal. Another child (15 years) with progressive familial intrahepatic cholestasis (PFIC) and pruritus, despite liver transplantation and biliary diversion, was studied. Selenium homocholic acid taurocholate scanning ((75)SeHCAT) capsule was given orally (n = 3) or via introducer during endoscopy (n = 2); a baseline whole-body gamma camera scan was done 4 hours later and on days 1 to 5. The normal 3-day bile salt retention is 30% to 70% of baseline and normal adult biological half-life, t½ is 62 ± 17 hours. The results in children with a stoma were very low (0.1% at 7.6 hours; 5% at 17 hours). The children with reversed stoma had retention and t½ closer to the reference range (18% at 29 hours; 22% at 33 hours). The child with PFIC + biliary diversion had an initial very high gamma emission from the stoma bag suggesting excellent reabsorption of bile salts from his TI, but retention was 0.6% and t½ 9.8 hours, demonstrating efficient biliary diversion. These results confirm children with stomas malabsorb bile acids, which can be ameliorated after stoma closure. SeHCAT demonstrated that the biliary diversion was working well and may be helpful in preoperative assessment of abnormal EHC. The role of SeHCAT in SBTx requires further evaluation. Copyright © 2014 Elsevier Inc. All rights reserved.

Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy.

PubMed

Xie, Yunhe; Bentefour, El Hassane; Janssens, Guillaume; Smeets, Julien; Vander Stappen, François; Hotoiu, Lucian; Yin, Lingshu; Dolney, Derek; Avery, Stephen; O'Grady, Fionnbarr; Prieels, Damien; McDonough, James; Solberg, Timothy D; Lustig, Robert A; Lin, Alexander; Teo, Boon-Keng K

2017-09-01

To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan. In 6 treatment fractions recorded over 3 weeks, the mean (± standard deviation) range shifts aggregated over all spots in 9 energy layers were -0.8 ± 1.3 mm for the lateral field, 1.7 ± 0.7 mm for the right-superior-oblique field, and -0.4 ± 0.9 mm for the vertex field. This study demonstrates the feasibility and illustrates the distinctive benefits of prompt gamma imaging in pencil beam scanning treatment mode. Accuracy in range verification was found in this first clinical case to be better than the range uncertainty margin applied in the treatment plan. These first results lay the foundation for additional work toward tighter integration of the system for in vivo proton range verification and quantification of range uncertainties. Copyright © 2017 Elsevier Inc. All rights reserved.

Camera identity from minute film-edge mark characteristics.

PubMed

Kuppuswamy, R

2003-07-08

A case is presented in which a camera recovered from a site of bomb blast was linked to some incriminating film negatives by the characteristic markings existing along a small portion of the edge of the film negatives.

Camera-Only Kinematics for Small Lunar Rovers

NASA Astrophysics Data System (ADS)

Fang, E.; Suresh, S.; Whittaker, W.

2016-11-01

Knowledge of the kinematic state of rovers is critical. Existing methods add sensors and wiring to moving parts, which can fail and adds mass and volume. This research presents a method to optically determine kinematic state using a single camera.

Ga:Ge array development

NASA Technical Reports Server (NTRS)

Young, Erick T.; Rieke, G. H.; Low, Frank J.; Haller, E. E.; Beeman, J. W.

1989-01-01

Work at the University of Arizona and at Lawrence Berkeley Laboratory on the development of a far infrared array camera for the Multiband Imaging Photometer on the Space Infrared Telescope Facility (SIRTF) is discussed. The camera design uses stacked linear arrays of Ge:Ga photoconductors to make a full two-dimensional array. Initial results from a 1 x 16 array using a thermally isolated J-FET readout are presented. Dark currents below 300 electrons s(exp -1) and readout noises of 60 electrons were attained. Operation of these types of detectors in an ionizing radiation environment are discussed. Results of radiation testing using both low energy gamma rays and protons are given. Work on advanced C-MOS cascode readouts that promise lower temperature operation and higher levels of performance than the current J-FET based devices is described.

The effect of microchannel plate gain depression on PAPA photon counting cameras

NASA Astrophysics Data System (ADS)

Sams, Bruce J., III

1991-03-01

PAPA (precision analog photon address) cameras are photon counting imagers which employ microchannel plates (MCPs) for image intensification. They have been used extensively in astronomical speckle imaging. The PAPA camera can produce artifacts when light incident on its MCP is highly concentrated. The effect is exacerbated by adjusting the strobe detection level too low, so that the camera accepts very small MCP pulses. The artifacts can occur even at low total count rates if the image has highly a concentrated bright spot. This paper describes how to optimize PAPA camera electronics, and describes six techniques which can avoid or minimize addressing errors.

Development of the Brican TD100 Small Uas and Payload Trials

NASA Astrophysics Data System (ADS)

Eggleston, B.; McLuckie, B.; Koski, W. R.; Bird, D.; Patterson, C.; Bohdanov, D.; Liu, H.; Mathews, T.; Gamage, G.

2015-08-01

The Brican TD100 is a high performance, small UAS designed and made in Brampton Ontario Canada. The concept was defined in late 2009 and it is designed for a maximum weight of 25 kg which is now the accepted cut-off defining small civil UASs. A very clean tractor propeller layout is used with a lightweight composite structure and a high aspect ratio wing to obtain good range and endurance. The design features and performance of the initial electrically powered version are discussed and progress with developing a multifuel engine version is described. The system includes features enabling operation beyond line of sight (BLOS) and the proving missions are described. The vehicle has been used for aerial photography and low cost mapping using a professional grade Nikon DSLR camera. For forest fire research a FLIR A65 IR camera was used, while for georeferenced mapping a new Applanix AP20 system was calibrated with the Nikon camera. The sorties to be described include forest fire research, wildlife photography of bowhead whales in the Arctic and surveys of endangered caribou in a remote area of Labrador, with all these applications including the DSLR camera.

Estimating tiger abundance from camera trap data: Field surveys and analytical issues

USGS Publications Warehouse

Karanth, K. Ullas; Nichols, James D.; O'Connell, Allan F.; Nichols, James D.; Karanth, K. Ullas

2011-01-01

Automated photography of tigers Panthera tigris for purely illustrative purposes was pioneered by British forester Fred Champion (1927, 1933) in India in the early part of the Twentieth Century. However, it was McDougal (1977) in Nepal who first used camera traps, equipped with single-lens reflex cameras activated by pressure pads, to identify individual tigers and study their social and predatory behaviors. These attempts involved a small number of expensive, cumbersome camera traps, and were not, in any formal sense, directed at “sampling” tiger populations.

Characterization of Lunar Swirls at Mare Ingenii: A Model for Space Weathering at Magnetic Anomalies

NASA Technical Reports Server (NTRS)

Kramer, Georgianna Y.; Combe, Jean-Philippe; Harnett, Erika M.; Hawke, Bernard Ray; Noble, Sarah K.; Blewett, David T.; McCord, Thomas B.; Giguere, Thomas A.

2011-01-01

Analysis of spectra from the Clementine ultraviolet-visible and near-infrared cameras of small, immature craters and surface soils both on and adjacent to the lunar swirls at Marc Ingenii has yielded the following conclusions about space weathering at a magnetic anomaly. (l) Despite having spectral characteristics of immaturity, the lunar swirls arc not freshly exposed surfaces. (2) The swirl surfaces arc regions of retarded weathering, while immediately adjacent regions experience accelerated weathering, (3) Weathering in the off-swirl regions darkens and flattens the spectrum with little to no reddening, which suggests that the production of larger (greater than 40 nm) nanophase iron dominates in these locations as a result of charged particle sorting by the magnetic field. Preliminaty analysis of two other lunar swirl regions, Reiner Gamma and Mare Marginis, is consistent with our observations at Mare Ingenii. Our results indicate that sputtering/vapor deposition, implanted solar wind hydrogen, and agglutination share responsibility for creating the range in npFe(sup 0) particle sizes responsible for the spectral effects of space weathering.

Lung clearance of /sup 99m/Tc-DTPA in patients with acute lung injury and pulmonary edema

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coates, G.; O'Brodovich, H.; Dolovich, M.

1988-07-01

Several acute and chronic conditions that alter the integrity of the pulmonary epithelium increased the rate of absorption or clearance into the circulation of small solutes deposited in the alveoli. Technetium 99m diethylenetriamine pentaacetic acid can be deposited in the lungs as a submicronic aerosol and its rate of clearance measured with a gamma camera or simple probe. This clearance technique is currently being used to evaluate patients who have developed pulmonary edema and also to detect those patients from a high risk group who are likely to develop adult respiratory distress syndrome (ARDS). Its role in the evaluation ofmore » patients with pulmonary edema is still under active investigation. It is clear that a single measurement in patients who smoke is not useful, but repeated measurements may provide important information. The lung clearance measurement is very sensitive to changes in epithelial integrity but is not specific for ARDS. It may be most useful in combination with other predictive tests or when the clearance rate is normal. 54 references.« less

Pre-Clinical and Clinical Evaluation of High Resolution, Mobile Gamma Camera and Positron Imaging Devices

DTIC Science & Technology

2007-11-01

accuracy. FPGA ADC data acquisition is controlled by distributed Java -based software. Java -based server application sits on each of the acquisition...JNI ( Java Native Interface) is used to allow Java indirect control of the USB driver. Fig. 5. Photograph of mobile electronics rack...supplies with the monitor and keyboard. The server application on each of these machines is controlled by a remote client Java -based application

Feasibility of using Eastman Kodak type 3400 film for high altitude multispectral photography

NASA Technical Reports Server (NTRS)

Perry, L.

1972-01-01

A photographic test flight of the NASA RB-57F was conducted on March 25, 1972, over Houston and West Texas, to determine the suitability of Eastman Kodak type 3400 film as a replacement for type 2402 film in the Hasselblad cameras. An additional purpose was to test GAF film type 2914, a new black and white film similar to 2402, but with higher maximum gamma and greater dynamic range.

Multiple-image oscilloscope camera

DOEpatents

Yasillo, Nicholas J.

1978-01-01

An optical device for placing automatically a plurality of images at selected locations on one film comprises a stepping motor coupled to a rotating mirror and lens. A mechanical connection from the mirror controls an electronic logical system to allow rotation of the mirror to place a focused image at the desired preselected location. The device is of especial utility when used to place four images on a single film to record oscilloscope views obtained in gamma radiography.

Embolization with Gamma Knife Radiosurgery of Giant Intracranial Arteriovenous Malformations.

PubMed

Chun, Dong Hyun; Kim, Moo Seong; Kim, Sung Tae; Paeng, Sung Hwa; Jeong, Hae Woong; Lee, Won Hee

2016-01-01

Giant arteriovenous malformations (i.e., those greater than 6 cm maximum diameter or volume > 33 cc) are difficult to treat and often carry higher treatment morbidity and mortality rates. In our study, we reviewed the angiographic results and clinical outcomes for 11 patients with giant arteriovenous malformations who were treated between 1994 and 2012. The patients selected included 9 males (82%) and 2 females (18%). Their presenting symptoms were hemorrhage (n=2; 18%), seizure (n=7; 64%), and headache (n=2; 12%). Nine patients were Spetzler-Martin Grade III, 2 were Spetzler-Martin Grade IV. The mean arteriovenous malformation volume was 41 cc (33-52 cc). The mean age of the patients was 45.1 years (24-57 years) and the mean radiation dose delivered to the margin of the nidus was 14.2 Gy. Ten patients received pre-Gamma Knife radiosurgery embolization and Gamma Knife radiosurgery, 1 patient received pre-Gamma Knife radiosurgery embolization and Gamma Knife radiosurgery twice and the interval between Gamma Knife radiosurgeries was 3 months. The complete obliteration rate following Gamma Knife radiosurgery was 36%, subtotal obliteration ( > 70% decreased size of nidus) was 36%, and partial obliteration was 28%. One patient experienced a small hemorrhage after embolization. Combined embolization and Gamma Knife radiosurgery showed successful obliteration of the arteriovenous malformation nidus. The use of embolization to initially reduce nidus size followed by Gamma Knife radiosurgery improves the treatment results. Repeated Gamma Knife radiosurgery should be a treatment option when there is a small nidus remnant.

Orthogonal strip HPGe planar SmartPET detectors in Compton configuration

NASA Astrophysics Data System (ADS)

Boston, H. C.; Gillam, J.; Boston, A. J.; Cooper, R. J.; Cresswell, J.; Grint, A. N.; Mather, A. R.; Nolan, P. J.; Scraggs, D. P.; Turk, G.; Hall, C. J.; Lazarus, I.; Berry, A.; Beveridge, T.; Lewis, R.

2007-10-01

The evolution of Germanium detector technology over the last decade has lead to the possibility that they can be employed in medical and security imaging. The potential of excellent energy resolution coupled with good position information that Germanium affords removes the necessity for mechanical collimators that would be required in a conventional gamma camera system. By removing this constraint, the overall dose to the patient can be reduced or the throughput of the system can be increased. An additional benefit of excellent energy resolution is that tight gates can be placed on energies from either a multi-lined gamma source or from multi-nuclide sources increasing the number of sources that can be used in medical imaging. In terms of security imaging, segmented Germanium gives directionality and excellent spectroscopic information.

In-Flight Observation of Gamma Ray Glows by ILDAS.

PubMed

Kochkin, Pavlo; van Deursen, A P J; Marisaldi, M; Ursi, A; de Boer, A I; Bardet, M; Allasia, C; Boissin, J-F; Flourens, F; Østgaard, N

2017-12-16

An Airbus A340 aircraft flew over Northern Australia with the In-Flight Lightning Damage Assessment System (ILDAS) installed onboard. A long-duration gamma ray emission was detected. The most intense emission was observed at 12 km altitude and lasted for 20 s. Its intensity was 20 times the background counts, and it was abruptly terminated by a distant lightning flash. In this work we reconstruct the aircraft path and event timeline. The glow-terminating flash triggered a discharge from the aircraft wing that was recorded by a video camera operating onboard. Another count rate increase was observed 6 min later and lasted for 30 s. The lightning activity as reported by ground networks in this region was analyzed. The measured spectra characteristics of the emission were estimated.

In-Flight Observation of Gamma Ray Glows by ILDAS

NASA Astrophysics Data System (ADS)

Kochkin, Pavlo; van Deursen, A. P. J.; Marisaldi, M.; Ursi, A.; de Boer, A. I.; Bardet, M.; Allasia, C.; Boissin, J.-F.; Flourens, F.; Østgaard, N.

2017-12-01

An Airbus A340 aircraft flew over Northern Australia with the In-Flight Lightning Damage Assessment System (ILDAS) installed onboard. A long-duration gamma ray emission was detected. The most intense emission was observed at 12 km altitude and lasted for 20 s. Its intensity was 20 times the background counts, and it was abruptly terminated by a distant lightning flash. In this work we reconstruct the aircraft path and event timeline. The glow-terminating flash triggered a discharge from the aircraft wing that was recorded by a video camera operating onboard. Another count rate increase was observed 6 min later and lasted for 30 s. The lightning activity as reported by ground networks in this region was analyzed. The measured spectra characteristics of the emission were estimated.

Computational analysis of kidney scintigrams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vrincianu, D.; Puscasu, E.; Creanga, D.

The scintigraphic investigation of normal and pathological kidneys was carried out using specialized gamma-camera device from nuclear medicine hospital department. Technetium 90m isotope with gamma radiation emission, coupled with vector molecules for kidney tissues was introduced into the subject body, its dynamics being recorded as data source for kidney clearance capacity. Two representative data series were investigated, corresponding to healthy and pathological organs respectively. The semi-quantitative tests applied for the comparison of the two distinct medical situations were: the shape of probability distribution histogram, the power spectrum, the auto-correlation function and the Lyapunov exponent. While power spectrum led to similarmore » results in both cases, significant differences were revealed by means of distribution probability, Lyapunov exponent and correlation time, recommending these numerical tests as possible complementary tools in clinical diagnosis.« less

CZT Detector Development for New Generation Hard-X Astronomical Instruments

NASA Astrophysics Data System (ADS)

Uslenghi, Michela; Conti, Giancarlo; D'Angelo, Sergio; Fiorini, Mauro; Quadrini, Egidio M.; Natalucci, Lorenzo; Ubertini, Pietro

2006-04-01

In the context of the definition of a future European gamma-ray mission, following the now on-orbit INTEGRAL observatory, we are carrying out a feasibility study on a Gamma Ray Wide Field Camera (5-500 KeV) for transient event detection. Recent achievements in high energy astronomy have validated the CZT detectors performances in terms of good spatial resolution, detection efficiency, energy resolution and low noise at room temperature. We started a development program aimed to explore the possibilities to improve and optimize the performance of this kind of detectors, acting at the level of both the readout system and crystal quality. Preliminary results of characterization of pixelated crystals provided by IMARAD (now Orbotech) are presented, along with their analysis and interpretation based on an analytical model of signal formation.

Midi-maxi computer interaction in the interpretation of nuclear medicine procedures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schlapper, G.A.

1977-01-01

A study of renal function with an Anger Gamma Camera coupled with a Digital Equipment Corporation Gamma-11 System and an IBM System 370 demonstrates the potential of quantitative determinations of physiological function through the application of midi-maxi computer interaction in the interpretation of nuclear medicine procedures. It is shown that radiotracers can provide an opportunity to assess physiological processes of renal function by noninvasively following the path of a tracer as a function of time. Time-activity relationships obtained over seven anatomically defined regions are related to parameters of a seven compartment model employed to describe the renal clearance process. Themore » values obtained for clinically significant parameters agree with known renal pathophysiology. Differentiation of failure of acute, chronic, and obstructive forms is indicated.« less

Improved camera for better X-ray powder photographs

NASA Technical Reports Server (NTRS)

Parrish, W.; Vajda, I. E.

1969-01-01

Camera obtains powder-type photographs of single crystals or polycrystalline powder specimens. X-ray diffraction photographs of a powder specimen are characterized by improved resolution and greater intensity. A reasonably good powder pattern of small samples can be produced for identification purposes.

An image-based array trigger for imaging atmospheric Cherenkov telescope arrays

NASA Astrophysics Data System (ADS)

Dickinson, Hugh; Krennrich, Frank; Weinstein, Amanda; Eisch, Jonathan; Byrum, Karen; Anderson, John; Drake, Gary

2018-05-01

It is anticipated that forthcoming, next generation, atmospheric Cherenkov telescope arrays will include a number of medium-sized telescopes that are constructed using a dual-mirror Schwarzschild-Couder configuration. These telescopes will sample a wide (8 °) field of view using a densely pixelated camera comprising over 104 individual readout channels. A readout frequency congruent with the expected single-telescope trigger rates would result in substantial data rates. To ameliorate these data rates, a novel, hardware-level Distributed Intelligent Array Trigger (DIAT) is envisioned. A copy of the DIAT operates autonomously at each telescope and uses reduced resolution imaging data from a limited subset of nearby telescopes to veto events prior to camera readout and any subsequent network transmission of camera data that is required for centralized storage or aggregation. We present the results of Monte-Carlo simulations that evaluate the efficacy of a "Parallax width" discriminator that can be used by the DIAT to efficiently distinguish between genuine gamma-ray initiated events and unwanted background events that are initiated by hadronic cosmic rays.

MINER - A Mobile Imager of Neutrons for Emergency Responders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldsmith, John E. M.; Brennan, James S.; Gerling, Mark D

2014-10-01

We have developed a mobile fast neutron imaging platform to enhance the capabilities of emergency responders in the localization and characterization of special nuclear material. This mobile imager of neutrons for emergency responders (MINER) is based on the Neutron Scatter Camera, a large segmented imaging system that was optimized for large-area search applications. Due to the reduced size and power requirements of a man-portable system, MINER has been engineered to fit a much smaller form factor, and to be operated from either a battery or AC power. We chose a design that enabled omnidirectional (4π) imaging, with only a ~twofoldmore » decrease in sensitivity compared to the much larger neutron scatter cameras. The system was designed to optimize its performance for neutron imaging and spectroscopy, but it does also function as a Compton camera for gamma imaging. This document outlines the project activities, broadly characterized as system development, laboratory measurements, and deployments, and presents sample results in these areas. Additional information can be found in the documents that reside in WebPMIS.« less

Attempt to the detection of small wildfire by the uncooled micro bolometer camera onboard 50 kg class satellite

NASA Astrophysics Data System (ADS)

Fukuhara, T.; Kouyama, T.; Kato, S.; Nakamura, R.

2016-12-01

University International Formation Mission (UNIFORM) in Japan started in 2011 is an ambitious project that specialized to surveillance of small wildfire to contribute to provide fire information for initial suppression. Final aim of the mission is to construct a constellation with several 50 kg class satellites for frequent and exclusive observation. The uncooled micro-bolometer camera with 640 x 480 pixels based on commercial products has been newly developed for the first satellite. It has been successfully launched on 24 May 2014 and injected to the Sun-Synchronous orbit at local time of 12:00 with altitude of 628 km. The camera has been detected considerable hotspots not only wildfire but also volcanoes. Brightness temperature observed on orbit has been verified and scale of observed wildfire has been roughly presumed; the smallest wildfire ever detected has flame zone less than 2 x 103 m2. It is one tenth of initial requirement estimated in design process; our camera has enough ability to discover small wildfire and to provide beneficial information for fire control with low cost and quick fabrication; it would contribute to practical utility especially in developing nations. A next camera is available for new wildfire mission with satellite constellation; it has already developed for flight. Pixel arrays increasing to 1024 x 768, spatial resolution becomes fine to detect smaller wildfire whereas the swath of image is kept. This camera would be applied to the future planetary mission for Mars and Asteroid explore, too. When it observes planetary surface, thermal inertia can be estimated from continuous observation. When it observes atmosphere, cloud-top altitude can be estimated from horizontal temperature distribution.

The iQID Camera: An Ionizing-Radiation Quantum Imaging Detector

DOE PAGES

Miller, Brian W.; Gregory, Stephanie J.; Fuller, Erin S.; ...

2014-06-11

We have developed and tested a novel, ionizing-radiation Quantum Imaging Detector (iQID). This scintillation-based detector was originally developed as a high-resolution gamma-ray imager, called BazookaSPECT, for use in single-photon emission computed tomography (SPECT). Recently, we have investigated the detectors response and imaging potential with other forms of ionizing radiation including alpha, neutron, beta, and fission fragment particles. The detector’s response to a broad range of ionizing radiation has prompted its new title. The principle operation of the iQID camera involves coupling a scintillator to an image intensifier. The scintillation light generated particle interactions is optically amplified by the intensifier andmore » then re-imaged onto a CCD/CMOS camera sensor. The intensifier provides sufficient optical gain that practically any CCD/CMOS camera can be used to image ionizing radiation. Individual particles are identified and their spatial position (to sub-pixel accuracy) and energy are estimated on an event-by-event basis in real time using image analysis algorithms on high-performance graphics processing hardware. Distinguishing features of the iQID camera include portability, large active areas, high sensitivity, and high spatial resolution (tens of microns). Although modest, iQID has energy resolution that is sufficient to discrimate between particles. Additionally, spatial features of individual events can be used for particle discrimination. An important iQID imaging application that has recently been developed is single-particle, real-time digital autoradiography. In conclusion, we present the latest results and discuss potential applications.« less

Vacuum compatible miniature CCD camera head

DOEpatents

Conder, Alan D.

2000-01-01

A charge-coupled device (CCD) camera head which can replace film for digital imaging of visible light, ultraviolet radiation, and soft to penetrating x-rays, such as within a target chamber where laser produced plasmas are studied. The camera head is small, capable of operating both in and out of a vacuum environment, and is versatile. The CCD camera head uses PC boards with an internal heat sink connected to the chassis for heat dissipation, which allows for close(0.04" for example) stacking of the PC boards. Integration of this CCD camera head into existing instrumentation provides a substantial enhancement of diagnostic capabilities for studying high energy density plasmas, for a variety of military industrial, and medical imaging applications.

Void fraction, bubble size and interfacial area measurements in co-current downflow bubble column reactor with microbubble dispersion

DOE PAGES

Hernandez-Alvarado, Freddy; Kalaga, Dinesh V.; Turney, Damon; ...

2017-05-06

Micro-bubbles dispersed in bubble column reactors have received great interest in recent years, due to their small size, stability, high gas-liquid interfacial area concentrations and longer residence times. The high gas-liquid interfacial area concentrations lead to high mass transfer rates compared to conventional bubble column reactors. In the present work, experiments have been performed in a down-flow bubble column reactor with micro-bubbles generated and dispersed by a novel mechanism to determine the gas-liquid interfacial area concentrations by measuring the void fraction and bubble size distributions. Gamma-ray densitometry has been employed to determine the axial and radial distributions of void fractionmore » and a high speed camera equipped with a borescope is used to measure the axial and radial variations of bubble sizes. Also, the effects of superficial gas and liquid velocities on the two-phase flow characteristics have been investigated. Further, reconstruction techniques of the radial void fraction profiles from the gamma densitometry's chordal measurements are discussed and compared for a bubble column reactor with dispersed micro-bubbles. The results demonstrate that the new bubble generation technique offers high interfacial area concentrations (1,000 to 4,500 m 2/m 3) with sub-millimeter bubbles (500 to 900 µm) and high overall void fractions (10% – 60%) in comparison with previous bubble column reactor designs. The void fraction data was analyzed using slip velocity model and empirical correlation has been proposed to predict the Sauter mean bubble diameter.« less

Void fraction, bubble size and interfacial area measurements in co-current downflow bubble column reactor with microbubble dispersion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hernandez-Alvarado, Freddy; Kalaga, Dinesh V.; Turney, Damon

Micro-bubbles dispersed in bubble column reactors have received great interest in recent years, due to their small size, stability, high gas-liquid interfacial area concentrations and longer residence times. The high gas-liquid interfacial area concentrations lead to high mass transfer rates compared to conventional bubble column reactors. In the present work, experiments have been performed in a down-flow bubble column reactor with micro-bubbles generated and dispersed by a novel mechanism to determine the gas-liquid interfacial area concentrations by measuring the void fraction and bubble size distributions. Gamma-ray densitometry has been employed to determine the axial and radial distributions of void fractionmore » and a high speed camera equipped with a borescope is used to measure the axial and radial variations of bubble sizes. Also, the effects of superficial gas and liquid velocities on the two-phase flow characteristics have been investigated. Further, reconstruction techniques of the radial void fraction profiles from the gamma densitometry's chordal measurements are discussed and compared for a bubble column reactor with dispersed micro-bubbles. The results demonstrate that the new bubble generation technique offers high interfacial area concentrations (1,000 to 4,500 m 2/m 3) with sub-millimeter bubbles (500 to 900 µm) and high overall void fractions (10% – 60%) in comparison with previous bubble column reactor designs. The void fraction data was analyzed using slip velocity model and empirical correlation has been proposed to predict the Sauter mean bubble diameter.« less

Computed radiography as a gamma ray detector—dose response and applications

NASA Astrophysics Data System (ADS)

O'Keeffe, D. S.; McLeod, R. W.

2004-08-01

Computed radiography (CR) can be used for imaging the spatial distribution of photon emissions from radionuclides. Its wide dynamic range and good response to medium energy gamma rays reduces the need for long exposure times. Measurements of small doses can be performed without having to pre-sensitize the computed radiography plates via an x-ray exposure, as required with screen-film systems. Cassette-based Agfa MD30 and Kodak GP25 CR plates were used in applications involving the detection of gamma ray emissions from technetium-99m and iodine-131. Cassette entrance doses as small as 1 µGy (140 keV gamma rays) produce noisy images, but the images are suitable for applications such as the detection of breaks in radiation protection barriers. A consequence of the gamma ray sensitivity of CR plates is the possibility that some nuclear medicine patients may fog their x-rays if the x-ray is taken soon after their radiopharmaceutical injection. The investigation showed that such fogging is likely to be diffuse.

Fixed-focus camera objective for small remote sensing satellites

NASA Astrophysics Data System (ADS)

Topaz, Jeremy M.; Braun, Ofer; Freiman, Dov

1993-09-01

An athermalized objective has been designed for a compact, lightweight push-broom camera which is under development at El-Op Ltd. for use in small remote-sensing satellites. The high performance objective has a fixed focus setting, but maintains focus passively over the full range of temperatures encountered in small satellites. The lens is an F/5.0, 320 mm focal length Tessar type, operating over the range 0.5 - 0.9 micrometers . It has a 16 degree(s) field of view and accommodates various state-of-the-art silicon detector arrays. The design and performance of the objective is described in this paper.

Inspecting rapidly moving surfaces for small defects using CNN cameras

NASA Astrophysics Data System (ADS)

Blug, Andreas; Carl, Daniel; Höfler, Heinrich

2013-04-01

A continuous increase in production speed and manufacturing precision raises a demand for the automated detection of small image features on rapidly moving surfaces. An example are wire drawing processes where kilometers of cylindrical metal surfaces moving with 10 m/s have to be inspected for defects such as scratches, dents, grooves, or chatter marks with a lateral size of 100 μm in real time. Up to now, complex eddy current systems are used for quality control instead of line cameras, because the ratio between lateral feature size and surface speed is limited by the data transport between camera and computer. This bottleneck is avoided by "cellular neural network" (CNN) cameras which enable image processing directly on the camera chip. This article reports results achieved with a demonstrator based on this novel analogue camera - computer system. The results show that computational speed and accuracy of the analogue computer system are sufficient to detect and discriminate the different types of defects. Area images with 176 x 144 pixels are acquired and evaluated in real time with frame rates of 4 to 10 kHz - depending on the number of defects to be detected. These frame rates correspond to equivalent line rates on line cameras between 360 and 880 kHz, a number far beyond the available features. Using the relation between lateral feature size and surface speed as a figure of merit, the CNN based system outperforms conventional image processing systems by an order of magnitude.

Sneaky Gamma-Rays: Using Gravitational Lensing to Avoid Gamma-Gamma-Absorption

NASA Astrophysics Data System (ADS)

Boettcher, Markus; Barnacka, Anna

2014-08-01

It has recently been suggested that gravitational lensing studies of gamma-ray blazars might be a promising avenue to probe the location of the gamma-ray emitting region in blazars. Motivated by these prospects, we have investigated potential gamma-gamma absorption signatures of intervening lenses in the very-high-energy gamma-ray emission from lensedblazars. We considered intervening galaxies and individual stars within these galaxies. We find that the collective radiation field of galaxies acting as sources of macrolensing are not expected to lead to significant gamma-gamma absorption. Individual stars within intervening galaxies could, in principle, cause a significant opacity to gamma-gamma absorption for VHE gamma-rays if the impact parameter (the distance of closest approach of the gamma-ray to the center of the star) is small enough. However, we find that the curvature of the photon path due to gravitational lensing will cause gamma-ray photons to maintain a sufficiently large distance from such stars to avoid significant gamma-gamma absorption. This re-inforces the prospect of gravitational-lensing studies of gamma-ray blazars without interference due to gamma-gamma absorption due to the lensing objects.

Cardiac phase-synchronized myocardial thallium-201 single-photon emission tomography using list mode data acquisition and iterative tomographic reconstruction.

PubMed

Vemmer, T; Steinbüchel, C; Bertram, J; Eschner, W; Kögler, A; Luig, H

1997-03-01

The purpose of this study was to determine whether data acquisition in the list mode and iterative tomographic reconstruction would render feasible cardiac phase-synchronized thallium-201 single-photon emission tomography (SPET) of the myocardium under routine conditions without modifications in tracer dose, acquisition time, or number of steps of the a gamma camera. Seventy non-selected patients underwent 201T1 SPET imaging according to a routine protocol (74 MBq/2 mCi 201T1, 180 degrees rotation of the gamma camera, 32 steps, 30 min). Gamma camera data, ECG, and a time signal were recorded in list mode. The cardiac cycle was divided into eight phases, the end-diastolic phase encompassing the QRS complex, and the end-systolic phase the T wave. Both phase- and non-phase-synchronized tomograms based on the same list mode data were reconstructed iteratively. Phase-synchronized and non-synchronized images were compared. Patients were divided into two groups depending on whether or not coronary artery disease had been definitely diagnosed prior to SPET imaging. The numbers of patients in both groups demonstrating defects visible on the phase-synchronized but not on the non-synchronized images were compared. It was found that both postexercise and redistribution phase tomograms were suited for interpretation. The changes from end-diastolic to end-systolic images allowed a comparative assessment of regional wall motility and tracer uptake. End-diastolic tomograms provided the best definition of defects. Additional defects not apparent on non-synchronized images were visible in 40 patients, six of whom did not show any defect on the non-synchronized images. Of 42 patients in whom coronary artery disease had been definitely diagnosed, 19 had additional defects not visible on the non-synchronized images, in comparison to 21 of 28 in whom coronary artery disease was suspected (P < 0.02; chi 2). It is concluded that cardiac phase-synchronized 201T1 SPET of the myocardium was made feasible by list mode data acquisition and iterative reconstruction. The additional findings on the phase-synchronized tomograms, not visible on the non-synchronized ones, represented genuine defects. Cardiac phase-synchronized 201T1 SPET is advantageous in allowing simultaneous assessment of regional wall motion and tracer uptake, and in visualizing smaller defects.

Automatic Spatio-Temporal Flow Velocity Measurement in Small Rivers Using Thermal Image Sequences

NASA Astrophysics Data System (ADS)

Lin, D.; Eltner, A.; Sardemann, H.; Maas, H.-G.

2018-05-01

An automatic spatio-temporal flow velocity measurement approach, using an uncooled thermal camera, is proposed in this paper. The basic principle of the method is to track visible thermal features at the water surface in thermal camera image sequences. Radiometric and geometric calibrations are firstly implemented to remove vignetting effects in thermal imagery and to get the interior orientation parameters of the camera. An object-based unsupervised classification approach is then applied to detect the interest regions for data referencing and thermal feature tracking. Subsequently, GCPs are extracted to orient the river image sequences and local hot points are identified as tracking features. Afterwards, accurate dense tracking outputs are obtained using pyramidal Lucas-Kanade method. To validate the accuracy potential of the method, measurements obtained from thermal feature tracking are compared with reference measurements taken by a propeller gauge. Results show a great potential of automatic flow velocity measurement in small rivers using imagery from a thermal camera.

Fluorescent image tracking velocimeter

DOEpatents

Shaffer, Franklin D.

1994-01-01

A multiple-exposure fluorescent image tracking velocimeter (FITV) detects and measures the motion (trajectory, direction and velocity) of small particles close to light scattering surfaces. The small particles may follow the motion of a carrier medium such as a liquid, gas or multi-phase mixture, allowing the motion of the carrier medium to be observed, measured and recorded. The main components of the FITV include: (1) fluorescent particles; (2) a pulsed fluorescent excitation laser source; (3) an imaging camera; and (4) an image analyzer. FITV uses fluorescing particles excited by visible laser light to enhance particle image detectability near light scattering surfaces. The excitation laser light is filtered out before reaching the imaging camera allowing the fluoresced wavelengths emitted by the particles to be detected and recorded by the camera. FITV employs multiple exposures of a single camera image by pulsing the excitation laser light for producing a series of images of each particle along its trajectory. The time-lapsed image may be used to determine trajectory and velocity and the exposures may be coded to derive directional information.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xing, Y; Macq, B; Bondar, L

Purpose: To quantify the accuracy in predicting the Bragg peak position using simulated in-room measurements of prompt gamma (PG) emissions for realistic treatment error scenarios that combine several sources of errors. Methods: Prompt gamma measurements by a knife-edge slit camera were simulated using an experimentally validated analytical simulation tool. Simulations were performed, for 143 treatment error scenarios, on an anthropomorphic phantom and a pencil beam scanning plan for nasal cavity. Three types of errors were considered: translation along each axis, rotation around each axis, and CT-calibration errors with magnitude ranging respectively, between −3 and 3 mm, −5 and 5 degrees,more » and between −5 and +5%. We investigated the correlation between the Bragg peak (BP) shift and the horizontal shift of PG profiles. The shifts were calculated between the planned (reference) position and the position by the error scenario. The prediction error for one spot was calculated as the absolute difference between the PG profile shift and the BP shift. Results: The PG shift was significantly and strongly correlated with the BP shift for 92% of the cases (p<0.0001, Pearson correlation coefficient R>0.8). Moderate but significant correlations were obtained for all cases that considered only CT-calibration errors and for 1 case that combined translation and CT-errors (p<0.0001, R ranged between 0.61 and 0.8). The average prediction errors for the simulated scenarios ranged between 0.08±0.07 and 1.67±1.3 mm (grand mean 0.66±0.76 mm). The prediction error was moderately correlated with the value of the BP shift (p=0, R=0.64). For the simulated scenarios the average BP shift ranged between −8±6.5 mm and 3±1.1 mm. Scenarios that considered combinations of the largest treatment errors were associated with large BP shifts. Conclusion: Simulations of in-room measurements demonstrate that prompt gamma profiles provide reliable estimation of the Bragg peak position for complex error scenarios. Yafei Xing and Luiza Bondar are funded by BEWARE grants from the Walloon Region. The work presents simulations results for a prompt gamma camera prototype developed by IBA.« less

Polarizing aperture stereoscopic cinema camera

NASA Astrophysics Data System (ADS)

Lipton, Lenny

2012-03-01

The art of stereoscopic cinematography has been held back because of the lack of a convenient way to reduce the stereo camera lenses' interaxial to less than the distance between the eyes. This article describes a unified stereoscopic camera and lens design that allows for varying the interaxial separation to small values using a unique electro-optical polarizing aperture design for imaging left and right perspective views onto a large single digital sensor (the size of the standard 35mm frame) with the means to select left and right image information. Even with the added stereoscopic capability the appearance of existing camera bodies will be unaltered.

Polarizing aperture stereoscopic cinema camera

NASA Astrophysics Data System (ADS)

Lipton, Lenny

2012-07-01

The art of stereoscopic cinematography has been held back because of the lack of a convenient way to reduce the stereo camera lenses' interaxial to less than the distance between the eyes. This article describes a unified stereoscopic camera and lens design that allows for varying the interaxial separation to small values using a unique electro-optical polarizing aperture design for imaging left and right perspective views onto a large single digital sensor, the size of the standard 35 mm frame, with the means to select left and right image information. Even with the added stereoscopic capability, the appearance of existing camera bodies will be unaltered.

High Sensitivity SPECT for Small Animals and Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Gregory S.

Imaging systems using single gamma-ray emitting radioisotopes typically implement collimators in order to form the images. However, a tradeoff in sensitivity is inherent in the use of collimators, and modern preclinical single-photon emission computed tomography (SPECT) systems detect a very small fraction of emitted gamma-rays (<0.3%). We have built a collimator-less system, which can reach sensitivity of 40% for 99mTc imaging, while still producing images of sufficient spatial resolution for certain applications in thin objects such as mice, small plants, and well plates used for in vitro experiments.

Mini Compton Camera Based on an Array of Virtual Frisch-Grid CdZnTe Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Wonho; Bolotnikov, Aleksey; Lee, Taewoong

In this study, we constructed a mini Compton camera based on an array of CdZnTe detectors and assessed its spectral and imaging properties. The entire array consisted of 6×6 Frisch-grid CdZnTe detectors, each with a size of 6×6 ×15 mm 3. Since it is easier and more practical to grow small CdZnTe crystals rather than large monolithic ones, constructing a mosaic array of parallelepiped crystals can be an effective way to build a more efficient, large-volume detector. With the fully operational CdZnTe array, we measured the energy spectra for 133Ba -, 137Cs -, 60Co-radiation sources; we also located these sourcesmore » using a Compton imaging approach. Although the Compton camera was small enough to hand-carry, its intrinsic efficiency was several orders higher than those generated in previous researches using spatially separated arrays, because our camera measured the interactions inside the CZT detector array, wherein the detector elements were positioned very close to each other. Lastly, the performance of our camera was compared with that based on a pixelated detector.« less

Mini Compton Camera Based on an Array of Virtual Frisch-Grid CdZnTe Detectors

DOE PAGES

Lee, Wonho; Bolotnikov, Aleksey; Lee, Taewoong; ...

2016-02-15

In this study, we constructed a mini Compton camera based on an array of CdZnTe detectors and assessed its spectral and imaging properties. The entire array consisted of 6×6 Frisch-grid CdZnTe detectors, each with a size of 6×6 ×15 mm 3. Since it is easier and more practical to grow small CdZnTe crystals rather than large monolithic ones, constructing a mosaic array of parallelepiped crystals can be an effective way to build a more efficient, large-volume detector. With the fully operational CdZnTe array, we measured the energy spectra for 133Ba -, 137Cs -, 60Co-radiation sources; we also located these sourcesmore » using a Compton imaging approach. Although the Compton camera was small enough to hand-carry, its intrinsic efficiency was several orders higher than those generated in previous researches using spatially separated arrays, because our camera measured the interactions inside the CZT detector array, wherein the detector elements were positioned very close to each other. Lastly, the performance of our camera was compared with that based on a pixelated detector.« less

Blinded evaluation of the effects of high definition and magnification on perceived image quality in laryngeal imaging.

PubMed

Otto, Kristen J; Hapner, Edie R; Baker, Michael; Johns, Michael M

2006-02-01

Advances in commercial video technology have improved office-based laryngeal imaging. This study investigates the perceived image quality of a true high-definition (HD) video camera and the effect of magnification on laryngeal videostroboscopy. We performed a prospective, dual-armed, single-blinded analysis of a standard laryngeal videostroboscopic examination comparing 3 separate add-on camera systems: a 1-chip charge-coupled device (CCD) camera, a 3-chip CCD camera, and a true 720p (progressive scan) HD camera. Displayed images were controlled for magnification and image size (20-inch [50-cm] display, red-green-blue, and S-video cable for 1-chip and 3-chip cameras; digital visual interface cable and HD monitor for HD camera). Ten blinded observers were then asked to rate the following 5 items on a 0-to-100 visual analog scale: resolution, color, ability to see vocal fold vibration, sense of depth perception, and clarity of blood vessels. Eight unblinded observers were then asked to rate the difference in perceived resolution and clarity of laryngeal examination images when displayed on a 10-inch (25-cm) monitor versus a 42-inch (105-cm) monitor. A visual analog scale was used. These monitors were controlled for actual resolution capacity. For each item evaluated, randomized block design analysis demonstrated that the 3-chip camera scored significantly better than the 1-chip camera (p < .05). For the categories of color and blood vessel discrimination, the 3-chip camera scored significantly better than the HD camera (p < .05). For magnification alone, observers rated the 42-inch monitor statistically better than the 10-inch monitor. The expense of new medical technology must be judged against its added value. This study suggests that HD laryngeal imaging may not add significant value over currently available video systems, in perceived image quality, when a small monitor is used. Although differences in clarity between standard and HD cameras may not be readily apparent on small displays, a large display size coupled with HD technology may impart improved diagnosis of subtle vocal fold lesions and vibratory anomalies.

Measurement of the timing behaviour of off-the-shelf cameras

NASA Astrophysics Data System (ADS)

Schatz, Volker

2017-04-01

This paper presents a measurement method suitable for investigating the timing properties of cameras. A single light source illuminates the camera detector starting with a varying defined delay after the camera trigger. Pixels from the recorded camera frames are summed up and normalised, and the resulting function is indicative of the overlap between illumination and exposure. This allows one to infer the trigger delay and the exposure time with sub-microsecond accuracy. The method is therefore of interest when off-the-shelf cameras are used in reactive systems or synchronised with other cameras. It can supplement radiometric and geometric calibration methods for cameras in scientific use. A closer look at the measurement results reveals deviations from the ideal camera behaviour of constant sensitivity limited to the exposure interval. One of the industrial cameras investigated retains a small sensitivity long after the end of the nominal exposure interval. All three investigated cameras show non-linear variations of sensitivity at O≤ft({{10}-3}\\right) to O≤ft({{10}-2}\\right) during exposure. Due to its sign, the latter effect cannot be described by a sensitivity function depending on the time after triggering, but represents non-linear pixel characteristics.

Solvation Free Energies of Alanine Peptides: The Effect of Flexibility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kokubo, Hironori; Harris, Robert C.; Asthagiri, Dilip

The electrostatic (?Gel), cavity-formation (?Gvdw), and total (?G) solvation free energies for 10 alanine peptides ranging in length (n) from 1 to 10 monomers were calculated. The free energies were computed both with xed, extended conformations of the peptides and again for some of the peptides without constraints. The solvation free energies, ?Gel, ?Gvdw, and ?G, were found to be linear in n, with the slopes of the best-fit lines being gamma_el, gamma_vdw, and gamma, respectively. Both gamma_el and gamma were negative for fixed and flexible peptides, and gamma_vdw was negative for fixed peptides. That gamma_vdw was negative was surprising,more » as experimental data on alkanes, theoretical models, and MD computations on small molecules and model systems generally suggest that gamma_vdw should be positive. A negative gamma_vdw seemingly contradicts the notion that ?Gvdw drives the initial collapse of the protein when it folds by favoring conformations with small surface areas, but when we computed ?Gvdw for the flexible peptides, thereby allowing the peptides to assume natural ensembles of more compact conformations, gamma-vdw was positive. Because most proteins do not assume extended conformations, a ?Gvdw that increases with increasing surface area may be typical for globular proteins. An alternative hypothesis is that the collapse is driven by intramolecular interactions. We show that the intramolecular van der Waal's interaction energy is more favorable for the flexible than for the extended peptides, seemingly favoring this hypothesis, but the large fluctuations in this energy may make attributing the collapse of the peptide to this intramolecular energy difficult.« less

Development of modern approach to absorbed dose assessment in radionuclide therapy, based on Monte Carlo method simulation of patient scintigraphy

NASA Astrophysics Data System (ADS)

Lysak, Y. V.; Klimanov, V. A.; Narkevich, B. Ya

2017-01-01

One of the most difficult problems of modern radionuclide therapy (RNT) is control of the absorbed dose in pathological volume. This research presents new approach based on estimation of radiopharmaceutical (RP) accumulated activity value in tumor volume, based on planar scintigraphic images of the patient and calculated radiation transport using Monte Carlo method, including absorption and scattering in biological tissues of the patient, and elements of gamma camera itself. In our research, to obtain the data, we performed modeling scintigraphy of the vial with administered to the patient activity of RP in gamma camera, the vial was placed at the certain distance from the collimator, and the similar study was performed in identical geometry, with the same values of activity of radiopharmaceuticals in the pathological target in the body of the patient. For correct calculation results, adapted Fisher-Snyder human phantom was simulated in MCNP program. In the context of our technique, calculations were performed for different sizes of pathological targets and various tumors deeps inside patient’s body, using radiopharmaceuticals based on a mixed β-γ-radiating (131I, 177Lu), and clear β- emitting (89Sr, 90Y) therapeutic radionuclides. Presented method can be used for adequate implementing in clinical practice estimation of absorbed doses in the regions of interest on the basis of planar scintigraphy of the patient with sufficient accuracy.

Electronics for a prototype variable field of view PET camera using the PMT-quadrant-sharing detector array

NASA Astrophysics Data System (ADS)

Li, H.; Wong, Wai-Hoi; Zhang, N.; Wang, J.; Uribe, J.; Baghaei, H.; Yokoyama, S.

1999-06-01

Electronics for a prototype high-resolution PET camera with eight position-sensitive detector modules has been developed. Each module has 16 BGO (Bi/sub 4/Ge/sub 3/O/sub 12/) blocks (each block is composed of 49 crystals). The design goals are component and space reduction. The electronics is composed of five parts: front-end analog processing, digital position decoding, fast timing, coincidence processing and master data acquisition. The front-end analog circuit is a zone-based structure (each zone has 3/spl times/3 PMTs). Nine ADCs digitize integration signals of an active zone identified by eight trigger clusters; each cluster is composed of six photomultiplier tubes (PMTs). A trigger corresponding to a gamma ray is sent to a fast timing board to obtain a time-mark, and the nine digitized signals are passed to the position decoding board, where a real block (four PMTs) can be picked out from the zone for position decoding. Lookup tables are used for energy discrimination and to identify the gamma-hit crystal location. The coincidence board opens a 70-ns initial timing window, followed by two 20-ns true/accidental time-mark lookup table windows. The data output from the coincidence board can be acquired either in sinogram mode or in list mode with a Motorola/IRONICS VME-based system.

Immunostaining for peroxisome proliferator gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas.

PubMed

Horvai, Andrew E; Schaefer, Jochen T; Nakakura, Eric K; O'Donnell, Richard J

2008-05-01

Dedifferentiated liposarcoma can be readily diagnosed by the juxtaposition of a well-differentiated liposarcoma to a nonlipogenic sarcoma. However, if the lipogenic component is not abundant due to surgical sampling or small biopsy, dedifferentiated liposarcoma can be difficult to distinguish from other poorly different sarcomas. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nuclear hormone receptor that plays a critical role in adipocyte differentiation. Prior studies have not only demonstrated PPAR-gamma mRNA in various subtypes of liposarcoma but have also shown that adipocyte differentiation can be induced in some liposarcomas by a PPAR-gamma agonist. In the present study, we investigated whether immunostaining for PPAR-gamma can be used to distinguish dedifferentiated liposarcoma from other retroperitoneal sarcomas. We examined a series of 40 dedifferentiated liposarcoma and compared the staining for PPAR-gamma to a series of 24 retroperitoneal sarcomas that lacked lipogenic differentiation. A monoclonal antibody against PPAR-gamma was used to stain formalin-fixed paraffin-embedded tissue. Specific nuclear immunostaining was present in 37/40 (93%) of the dedifferentiated liposarcoma and 6/24 (25%) of the other sarcomas (two leiomyosarcomas and four undifferentiated sarcomas). Interestingly, immunostaining for CDK4 and/or MDM2 was identified in three of the four PPAR-gamma-positive undifferentiated sarcomas, raising the possibility that these may represent dedifferentiated liposarcoma. This is the first study demonstrating the utility of PPAR-gamma immunohistochemistry in the diagnosis of dedifferentiated liposarcoma in tissue sections. Although not completely specific, the presence of PPAR-gamma staining, in combination with histologic findings and other markers, can aid in the diagnosis of dedifferentiated liposarcoma, particularly on small biopsies that may not sample the well-differentiated component.

Small format digital photogrammetry for applications in the earth sciences

NASA Astrophysics Data System (ADS)

Rieke-Zapp, Dirk

2010-05-01

Small format digital photogrammetry for applications in the earth sciences Photogrammetry is often considered one of the most precise and versatile surveying techniques. The same camera and analysis software can be used for measurements from sub-millimetre to kilometre scale. Such a measurement device is well suited for application by earth scientists working in the field. In this case a small toolset and a straight forward setup best fit the needs of the operator. While a digital camera is typically already part of the field equipment of an earth scientist the main focus of the field work is often not surveying. Lack in photogrammetric training at the same time requires an easy to learn, straight forward surveying technique. A photogrammetric method was developed aimed primarily at earth scientists for taking accurate measurements in the field minimizing extra bulk and weight of the required equipment. The work included several challenges. A) Definition of an upright coordinate system without heavy and bulky tools like a total station or GNS-Sensor. B) Optimization of image acquisition and geometric stability of the image block. C) Identification of a small camera suitable for precise measurements in the field. D) Optimization of the workflow from image acquisition to preparation of images for stereo measurements. E) Introduction of students and non-photogrammetrists to the workflow. Wooden spheres were used as target points in the field. They were more rugged and available in different sizes than ping pong balls used in a previous setup. Distances between three spheres were introduced as scale information in a photogrammetric adjustment. The distances were measured with a laser distance meter accurate to 1 mm (1 sigma). The vertical angle between the spheres was measured with the same laser distance meter. The precision of the measurement was 0.3° (1 sigma) which is sufficient, i.e. better than inclination measurements with a geological compass. The upright coordinate system is important to measure the dip angle of geologic features in outcrop. The planimetric coordinate systems would be arbitrary, but may easily be oriented to compass north introducing a direction measurement of a compass. Wooden spheres and a Leica disto D3 laser distance meter added less than 0.150 kg to the field equipment considering that a suitable digital camera was already part of it. Identification of a small digital camera suitable for precise measurements was a major part of this work. A group of cameras were calibrated several times over different periods of time on a testfield. Further evaluation involved an accuracy assessment in the field comparing distances between signalized points calculated form a photogrammetric setup with coordinates derived from a total station survey. The smallest camera in the test required calibration on the job as the interior orientation changed significantly between testfield calibration and use in the field. We attribute this to the fact that the lens was retracted then the camera was switched off. Fairly stable camera geometry in a compact size camera with lens retracting system was accomplished for Sigma DP1 and DP2 cameras. While the pixel count of the cameras was less than for the Ricoh, the pixel pitch in the Sigma cameras was much larger. Hence, the same mechanical movement would have less per pixel effect for the Sigma cameras than for the Ricoh camera. A large pixel pitch may therefore compensate for some camera instability explaining why cameras with large sensors and larger pixel pitch typically yield better accuracy in object space. Both Sigma cameras weigh approximately 0.250 kg and may even be suitable for use with ultralight aerial vehicles (UAV) which have payload restriction of 0.200 to 0.300 kg. A set of other cameras that were available were also tested on a calibration field and on location showing once again that it is difficult to reason geometric stability from camera specifications. Image acquisition with geometrically stable cameras was fairly straight forward to cover the area of interest with stereo pairs for analysis. We limited our tests to setups with three to five images to minimize the amount of post processing. The laser dot of the laser distance meter was not visible for distances farther than 5-7 m with the naked eye which also limited the maximum stereo area that may be covered with this technique. Extrapolating the setup to fairly large areas showed no significant decrease in accuracy accomplished in object space. Working with a Sigma SD14 SLR camera on a 6 x 18 x 20 m3 volume the maximum length measurement error ranged between 20 and 30 mm depending on image setup and analysis. For smaller outcrops even the compact cameras yielded maximum length measurement errors in the mm range which was considered sufficient for measurements in the earth sciences. In many cases the resolution per pixel was the limiting factor of image analysis rather than accuracy. A field manual was developed guiding novice users and students to this technique. The technique does not simplify ease of use for precision; therefore successful users of the presented method easily grow into more advanced photogrammetric methods for high precision applications. Originally camera calibration was not part of the methodology for the novice operators. Recent introduction of Camera Calibrator which is a low cost, well automated software for camera calibration, allowed beginners to calibrate their camera within a couple minutes. The complete set of calibration parameters can be applied in ERDAS LPS software easing the workflow. Image orientation was performed in LPS 9.2 software which was also used for further image analysis.

Gamma Ray Burst Discoveries by the Swift Mission

NASA Astrophysics Data System (ADS)

Gehrels, N.; Swift Team

2005-12-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA Swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit after a beautiful launch on November 20, 2004. A new-technology wide-field gamma-ray camera detects more than a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. The long-standing mystery of short GRBs has been solved, and the answer is the most interesting possible scenario. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow. These, and other topics, will be discussed.

Gamma Ray Burst Discoveries by the Swift Mission

NASA Astrophysics Data System (ADS)

Gehrels, Neil

2006-04-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA Swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit since November 20, 2004 and all hardware is performing well. A new-technology wide-field gamma-ray camera is detecting a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 50-100 sec by an autonomously controlled ``swift'' spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. There has been a break-through in the long-standing mystery of short GRBs; they appear to be caused by merging neutron stars. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow.

Gamma Ray Burst Discoveries by the Swift Mission

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2006-01-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit since November 20, 2004 and all hardware is performing well. A new-technology wide-field gamma-ray camera is detecting a hundred bursts per year. sensitive narrow-field X-ray and uv/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 50-100 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. There has been a break-through in the longstanding mystery of short GRBs; they appear to be caused by merging neutron stars. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow.

Gamma Ray Burst Discoveries by the Swift Mission

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2006-01-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA Swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit after a beautiful launch on November 20, 2004. A new-technology wide-field gamma-ray camera detects more than a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. The long-standing mystery of short GRBs has been solved, and the answer is the most interesting possible scenario. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow. These, and other topics, will be discussed.

Characterization of a compact LaBr3(Ce) detector with Silicon photomultipliers at high 14 MeV neutron fluxes

NASA Astrophysics Data System (ADS)

Rigamonti, D.; Nocente, M.; Giacomelli, L.; Tardocchi, M.; Angelone, M.; Broslawski, A.; Cazzaniga, C.; Figueiredo, J.; Gorini, G.; Kiptily, V.; Korolczuk, S.; Murari, A.; Pillon, M.; Pilotti, R.; Zychor, I.; Contributors, JET

2017-10-01

A new compact gamma-ray spectrometer based on a Silicon Photo-Multiplier (SiPM) coupled to a LaBr3(Ce) crystal has been developed for the upgrade of the Gamma Camera (GC) of JET, where it must operate in a high intensity neutron/gamma-ray admixed field. The work presents the results of an experiment aimed at characterizing the effect of 14 MeV neutron irradiation on both LaBr3(Ce) and SiPM that compose the full detector. The pulse height spectrum from neutron interactions with the crystal has been measured and is successfully reproduced by MCNP simulations. It is calculated that about 8% of the impinging neutrons leave a detectable signal of which less than < 4% of the events occur in the energy region above 3 MeV, which is of interest for gamma-ray spectroscopy applications. Neutron irradiation also partly degrades the performance of the SiPM and this is mostly manifested as an increase of the dark current versus the neutron fluence. However, it was found that the SiPM can be still operated up to a fluence of 4×1010 n/cm2, which is the highest value we experimentally tested. Implications of these results for GC measurements at JET are discussed.

First On-Site True Gamma-Ray Imaging-Spectroscopy of Contamination near Fukushima Plant

PubMed Central

Tomono, Dai; Mizumoto, Tetsuya; Takada, Atsushi; Komura, Shotaro; Matsuoka, Yoshihiro; Mizumura, Yoshitaka; Oda, Makoto; Tanimori, Toru

2017-01-01

We have developed an Electron Tracking Compton Camera (ETCC), which provides a well-defined Point Spread Function (PSF) by reconstructing a direction of each gamma as a point and realizes simultaneous measurement of brightness and spectrum of MeV gamma-rays for the first time. Here, we present the results of our on-site pilot gamma-imaging-spectroscopy with ETCC at three contaminated locations in the vicinity of the Fukushima Daiichi Nuclear Power Plants in Japan in 2014. The obtained distribution of brightness (or emissivity) with remote-sensing observations is unambiguously converted into the dose distribution. We confirm that the dose distribution is consistent with the one taken by conventional mapping measurements with a dosimeter physically placed at each grid point. Furthermore, its imaging spectroscopy, boosted by Compton-edge-free spectra, reveals complex radioactive features in a quantitative manner around each individual target point in the background-dominated environment. Notably, we successfully identify a “micro hot spot” of residual caesium contamination even in an already decontaminated area. These results show that the ETCC performs exactly as the geometrical optics predicts, demonstrates its versatility in the field radiation measurement, and reveals potentials for application in many fields, including the nuclear industry, medical field, and astronomy. PMID:28155883

In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets.

PubMed

Li, Wei; Shi, Cai-Hong; Sheng, Yi-Ling; Cui, Ping; Zhao, Yu-Qing; Zhang, Xiang-Rong

2013-12-01

The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/ Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L-1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies.

Investigation of runaway electron dissipation in DIII-D using a gamma ray imager

NASA Astrophysics Data System (ADS)

Lvovskiy, A.; Paz-Soldan, C.; Eidietis, N.; Pace, D.; Taussig, D.

2017-10-01

We report the findings of a novel gamma ray imager (GRI) to study runaway electron (RE) dissipation in the quiescent regime on the DIII-D tokamak. The GRI measures the bremsstrahlung emission by RE providing information on RE energy spectrum and distribution across a poloidal cross-section. It consists of a lead pinhole camera illuminating a matrix of BGO detectors placed in the DIII-D mid-plane. The number of detectors was recently doubled to provide better spatial resolution and additional detector shielding was implemented to reduce un-collimated gamma flux and increase single-to-noise ratio. Under varying loop voltage, toroidal magnetic field and plasma density, a non-monotonic RE distribution function has been revealed as a result of the interplay between electric field, synchrotron radiation and collisional damping. A fraction of the high-energy RE population grows forming a bump at the RE distribution function while synchrotron radiation decreases. A possible destabilizing effect of Parail-Pogutse instability on the RE population will be also discussed. Work supported by the US DOE under DE-FC02-04ER54698.

Astronomy and the camera obscura

NASA Astrophysics Data System (ADS)

Feist, M.

2000-02-01

The camera obscura (from Latin meaning darkened chamber) is a simple optical device with a long history. In the form considered here, it can be traced back to 1550. It had its heyday during the Victorian era when it was to be found at the seaside as a tourist attraction or sideshow. It was also used as an artist's drawing aid and, in 1620, the famous astronomer-mathematician, Johannes Kepler used a small tent camera obscura to trace the scenery.

Instrumentation for Aim Point Determination in the Close-in Battle

DTIC Science & Technology

2007-12-01

Rugged camcorder with remote “ lipstick ” camera (http://www.samsung.com/Products/ Camcorder/DigitalMemory/files/scx210wl.pdf). ........ 5 Figure 5...target. One way of making a measurement is to mount a small “ lipstick ” camera to the rifle with a mount similar to the laser-tag transmitter mount...technology.com/contractors/surveillance/viotac-inc/viotac-inc1.html). Figure 4. Rugged camcorder with remote “ lipstick ” camera (http://www.samsung.com

Development of a calibration protocol for quantitative imaging for molecular radiotherapy dosimetry

NASA Astrophysics Data System (ADS)

Wevrett, J.; Fenwick, A.; Scuffham, J.; Nisbet, A.

2017-11-01

Within the field of molecular radiotherapy, there is a significant need for standardisation in dosimetry, in both quantitative imaging and dosimetry calculations. Currently, there are a wide range of techniques used by different clinical centres and as a result there is no means to compare patient doses between centres. To help address this need, a 3 year project was funded by the European Metrology Research Programme, and a number of clinical centres were involved in the project. One of the required outcomes of the project was to develop a calibration protocol for three dimensional quantitative imaging of volumes of interest. Two radionuclides were selected as being of particular interest: iodine-131 (131I, used to treat thyroid disorders) and lutetium-177 (177Lu, used to treat neuroendocrine tumours). A small volume of activity within a scatter medium (water), representing a lesion within a patient body, was chosen as the calibration method. To ensure ease of use in clinical centres, an "off-the-shelf" solution was proposed - to avoid the need for in-house manufacturing. The BIODEX elliptical Jaszczak phantom and 16 ml fillable sphere were selected. The protocol was developed for use on SPECT/CT gamma cameras only, where the CT dataset would be used to correct the imaging data for attenuation of the emitted photons within the phantom. The protocol corrects for scatter of emitted photons using the triple energy window correction technique utilised by most clinical systems. A number of clinical systems were tested in the development of this protocol, covering the major manufacturers of gamma camera generally used in Europe. Initial imaging was performed with 131I and 177Lu at a number of clinical centres, but due to time constraints in the project, some acquisitions were performed with 177Lu only. The protocol is relatively simplistic, and does not account for the effects of dead-time in high activity patients, the presence of background activity surrounding volumes of interest or the partial volume effect of imaging lesions smaller than 16 ml. The development of this simple protocol demonstrates that it is possible to produce a standardised quantitative imaging protocol for molecular radiotherapy dosimetry. However, the protocol needs further development to expand it to incorporate other radionuclides, and to account for the effects that have been disregarded in this initial version.

Printed circuit board for a CCD camera head

DOEpatents

Conder, Alan D.

2002-01-01

A charge-coupled device (CCD) camera head which can replace film for digital imaging of visible light, ultraviolet radiation, and soft to penetrating x-rays, such as within a target chamber where laser produced plasmas are studied. The camera head is small, capable of operating both in and out of a vacuum environment, and is versatile. The CCD camera head uses PC boards with an internal heat sink connected to the chassis for heat dissipation, which allows for close (0.04" for example) stacking of the PC boards. Integration of this CCD camera head into existing instrumentation provides a substantial enhancement of diagnostic capabilities for studying high energy density plasmas, for a variety of military industrial, and medical imaging applications.

A Portable, Inexpensive, Nonmydriatic Fundus Camera Based on the Raspberry Pi® Computer.

PubMed

Shen, Bailey Y; Mukai, Shizuo

2017-01-01

Purpose. Nonmydriatic fundus cameras allow retinal photography without pharmacologic dilation of the pupil. However, currently available nonmydriatic fundus cameras are bulky, not portable, and expensive. Taking advantage of recent advances in mobile technology, we sought to create a nonmydriatic fundus camera that was affordable and could be carried in a white coat pocket. Methods. We built a point-and-shoot prototype camera using a Raspberry Pi computer, an infrared-sensitive camera board, a dual infrared and white light light-emitting diode, a battery, a 5-inch touchscreen liquid crystal display, and a disposable 20-diopter condensing lens. Our prototype camera was based on indirect ophthalmoscopy with both infrared and white lights. Results. The prototype camera measured 133mm × 91mm × 45mm and weighed 386 grams. The total cost of the components, including the disposable lens, was $185.20. The camera was able to obtain good-quality fundus images without pharmacologic dilation of the pupils. Conclusion. A fully functional, inexpensive, handheld, nonmydriatic fundus camera can be easily assembled from a relatively small number of components. With modest improvements, such a camera could be useful for a variety of healthcare professionals, particularly those who work in settings where a traditional table-mounted nonmydriatic fundus camera would be inconvenient.

A Portable, Inexpensive, Nonmydriatic Fundus Camera Based on the Raspberry Pi® Computer

PubMed Central

Shen, Bailey Y.

2017-01-01

Purpose. Nonmydriatic fundus cameras allow retinal photography without pharmacologic dilation of the pupil. However, currently available nonmydriatic fundus cameras are bulky, not portable, and expensive. Taking advantage of recent advances in mobile technology, we sought to create a nonmydriatic fundus camera that was affordable and could be carried in a white coat pocket. Methods. We built a point-and-shoot prototype camera using a Raspberry Pi computer, an infrared-sensitive camera board, a dual infrared and white light light-emitting diode, a battery, a 5-inch touchscreen liquid crystal display, and a disposable 20-diopter condensing lens. Our prototype camera was based on indirect ophthalmoscopy with both infrared and white lights. Results. The prototype camera measured 133mm × 91mm × 45mm and weighed 386 grams. The total cost of the components, including the disposable lens, was $185.20. The camera was able to obtain good-quality fundus images without pharmacologic dilation of the pupils. Conclusion. A fully functional, inexpensive, handheld, nonmydriatic fundus camera can be easily assembled from a relatively small number of components. With modest improvements, such a camera could be useful for a variety of healthcare professionals, particularly those who work in settings where a traditional table-mounted nonmydriatic fundus camera would be inconvenient. PMID:28396802

System Integration of FastSPECT III, a Dedicated SPECT Rodent-Brain Imager Based on BazookaSPECT Detector Technology

PubMed Central

Miller, Brian W.; Furenlid, Lars R.; Moore, Stephen K.; Barber, H. Bradford; Nagarkar, Vivek V.; Barrett, Harrison H.

2010-01-01

FastSPECT III is a stationary, single-photon emission computed tomography (SPECT) imager designed specifically for imaging and studying neurological pathologies in rodent brain, including Alzheimer’s and Parkinsons’s disease. Twenty independent BazookaSPECT [1] gamma-ray detectors acquire projections of a spherical field of view with pinholes selected for desired resolution and sensitivity. Each BazookaSPECT detector comprises a columnar CsI(Tl) scintillator, image-intensifier, optical lens, and fast-frame-rate CCD camera. Data stream back to processing computers via firewire interfaces, and heavy use of graphics processing units (GPUs) ensures that each frame of data is processed in real time to extract the images of individual gamma-ray events. Details of the system design, imaging aperture fabrication methods, and preliminary projection images are presented. PMID:21218137

The Science and Design of the AGIS Observatory

NASA Astrophysics Data System (ADS)

Schroedter, Martin

2010-02-01

The AGIS observatory is a next-generation array of imaging atmospheric Cherenkov telescopes (IACTs) for gamma-ray astronomy between 100 GeV and 100 TeV. The AGIS observatory is the next logical step in high energy gamma-ray astronomy, offering improved angular resolution and sensitivity compared to FERMI, and overlapping the high energy end of FERMI's sensitivity band. The baseline AGIS observatory will employ an array of 36 Schwarzschild-Couder IACTs in combination with a highly pixelated (0.05^o diameter) camera. The instrument is designed to provide millicrab sensitivity over a wide (8^o diameter) field of view, allowing both deep studies of faint point sources as well as efficient mapping of the Galactic plane and extended sources. I will describe science drivers behind the AGIS observatory and the design and status of the project. )

The Science and Design of the AGIS Observatory

NASA Astrophysics Data System (ADS)

Falcone, Abraham; Aliu, E.; Arlen, T.; Benbow, W.; Buckley, J.; Bugaev, S.; Byrum, K.; Ciupik, L.; Coppi, P.; Digel, S.; Drake, G.; Finley, J.; Fortson, L.; Franco, J.; Funk, S.; Guarino, V.; Gyuk, G.; Hanna, D.; Hiriart, D.; Humensky, B.; Holder, J.; Kaaret, P.; Karlsson, N.; Kieda, D.; Konopelko, A.; Krawczynski, H.; Krennrich, F.; LeBohec, S.; Maier, G.; Mukherjee, R.; Ong, R.; Otte, N.; Pareschi, G.; Pohl, M.; Quinn, J.; Ramsey, B.; Romani, R.; Rovero, A. C.; Schroedter, M.; Sinnis, C.; Slane, P.; Smith, A.; Swordy, S.; Tajima, H.; Vassiliev, V.; Wagner, R.; Wakely, S. P.; Weekes, T. C.; Weinstein, A.; Williams, D.

2010-01-01

The AGIS observatory is a next-generation array of imaging atmospheric Cherenkov telescopes (IACTs) for gamma-ray astronomy between 100GeV and 100 TeV. The AGIS observatory is the next logical step in high energy gamma-ray astronomy, offering improved angular resolution and sensitivity compared to FERMI, and overlapping the high energy end of FERMI's sensitivity band. The baseline AGIS observatory will employ an array of 36 Schwarzschild-Couder IACTs in combination with a highly pixelated (0.05 degree/pixel) camera. The instrument is designed to provide millicrab sensitivity over a wide (8 degree diameter) field of view, allowing both deep studies of faint point sources as well as efficient mapping of the Galactic plane and extended sources. This presentation will include a description of science drivers behind the AGIS observatory and the design and status of the project.

Combination neutron-gamma ray detector

DOEpatents

Stuart, Travis P.; Tipton, Wilbur J.

1976-10-26

A radiation detection system capable of detecting neutron and gamma events and distinguishing therebetween. The system includes a detector for a photomultiplier which utilizes a combination of two phosphor materials, the first of which is in the form of small glass beads which scintillate primarily in response to neutrons and the second of which is a plastic matrix which scintillates in response to gammas. A combination of pulse shape and pulse height discrimination techniques is utilized to provide an essentially complete separation of the neutron and gamma events.

Small Unmanned Aerial Vehicles; DHS’s Answer to Border Surveillance Requirements

DTIC Science & Technology

2013-03-01

5 of more than 4000 illegal aliens, including the seizure of more than 15,000 pounds of marijuana .13 In addition to the Predator UAVs being...payload includes two color video cameras, an infrared camera that offers night vision capability and synthetic aperture radar that provides high

Orbital-science investigation: Part C: photogrammetry of Apollo 15 photography

USGS Publications Warehouse

Wu, Sherman S.C.; Schafer, Francis J.; Jordan, Raymond; Nakata, Gary M.; Derick, James L.

1972-01-01

Mapping of large areas of the Moon by photogrammetric methods was not seriously considered until the Apollo 15 mission. In this mission, a mapping camera system and a 61-cm optical-bar high-resolution panoramic camera, as well as a laser altimeter, were used. The mapping camera system comprises a 7.6-cm metric terrain camera and a 7.6-cm stellar camera mounted in a fixed angular relationship (an angle of 96° between the two camera axes). The metric camera has a glass focal-plane plate with reseau grids. The ground-resolution capability from an altitude of 110 km is approximately 20 m. Because of the auxiliary stellar camera and the laser altimeter, the resulting metric photography can be used not only for medium- and small-scale cartographic or topographic maps, but it also can provide a basis for establishing a lunar geodetic network. The optical-bar panoramic camera has a 135- to 180-line resolution, which is approximately 1 to 2 m of ground resolution from an altitude of 110 km. Very large scale specialized topographic maps for supporting geologic studies of lunar-surface features can be produced from the stereoscopic coverage provided by this camera.

Hard gamma radiation background from coding collimator of gamma telescope under space experiment conditions

NASA Astrophysics Data System (ADS)

Aleksandrov, A. P.; Berezovoy, A. N.; Galper, A. M.; Grachev, V. M.; Dmitrenko, V. V.; Kirillov-Ugryumov, V. G.; Lebedev, V. V.; Lyakhov, V. A.; Moiseyev, A. A.; Ulin, S. Y.

1985-09-01

Coding collimators are used to improve the angular resolution of gamma-ray telescopes at energies above 50 MeV. However, the interaction of cosmic rays with the collimation material can lead to the appearance of a gamma-ray background flux which can have a deleterious effect on measurement efficiency. An experiment was performed on the Salyut-6-Soyuz spacecraft system with the Elena-F small-scale gamma-ray telescope in order to measure the magnitude of this background. It is shown that, even at a zenith angle of approximately zero degrees (the angle at which the gamma-ray observations are made), the coding collimator has only an insignificant effect on the background conditions.

Low energy gamma ray emission from the Cygnus OB2 association

NASA Technical Reports Server (NTRS)

Chen, Wan; White, Richard L.

1992-01-01

According to our newly developed model of gamma-ray emission from chaotic early-type stellar winds, we predict the combined gamma-ray flux from the circumstellar winds of many very luminous early-type stars in the Cyg OB2 association can be detectable by the Energetic Gamma Ray Experiment Telescope (EGRET) (and maybe also by OSSE) on CGRO. Due to different radiation mechanisms, the gamma-ray spectrum from stellar winds can be quite different from that of CYG X-3; this spectral difference and the time-variation of Cyg X-3 flux will help to distinguish the gamma-ray components from different sources in this small region, which is spatially unresolvable by CGRO.

Instruments for Planetary Exploration with CubeSats and SmallSats

NASA Astrophysics Data System (ADS)

Raymond, Carol; Jaumann, Ralf; Vane, Gregg; Baker, John; Castillo-Rogez, Julie; Yano, Hajime

2016-07-01

Planetary sensors and instruments are undergoing a revolutionary transformation as solid-state electronics and advanced detectors allow drastic reductions in size, mass and power relative to instruments flown in the past. Given their reduced resource needs, these capable new systems are potentially compatible with use on smallsats. New built-in processing techniques further enable increased science return in constrained resource environments. In the summer of 2014 an international group of scientists, engineers, and technologists started a study to define investigations to be carried out by nano-spacecraft, and instruments that would enable breakthrough science from these small platforms were identified. The possibilities include passive remote sensing instruments such as imagers, spectrometers, magnetometers, dust analyzers; active instruments such as radar, lidar, laser-induced breakdown spectroscopy (LIBS), muonography, projectiles; and landed packages and in-situ probes such as instrumented penetrators, seismometers, and in-situ sample analysis packages. Many of the passive and active instruments could be used in-situ for very high-resolution measurements over limited areas. Smallsats lend themselves to observing strategies that allow dense spatial and temporal sampling using multiple flight system elements, covering a range of observing conditions, and multi-scale measurements with concurrent surface and remote observations. The lower cost of smallsats allows visiting a large range of targets and provides an architecture for cooperating distributed networks of sensors. The current state-of-the-art in smallsat payloads includes instrument suites on the Philae lander (Rosetta), and the MINERVA-II rovers and MASCOT on Hayabusa-2. Many Cubesat form factor instruments are either built or in development, including impactors and penetrators, and several new technologies are making their debut in the smallsat arena. The Philae payload included the CONSERT active radar experiment, MUPUS hammer and heat flow probes, magnetometer, ROLIS cameras and ROSINA mass spectrometer. MASCOT carries MicrOmega (NIR spectrometer), magnetometer, camera, and radiometer. The INSPIRE Cubesat mission carries a 1/2U Vector Helium Magnetometer. An intelligent camera maturing for flight in 2018 on the NEA Scout Cubesat mission promises to deliver a low-cost dual-use navigation and science capability at Cubesat scale. Cubesat versions of VIS-IR imaging spectrometers, neutron and gamma-ray spectrometers, mass spectrometers, tunable laser diode spectrometer and active radar are under development. Acknowledgements: This study is sponsored by the International Academy of Astronautics (IAA). Part of this work is being carried out at the Jet Propulsion Lab, California Institute of Technology, under contract to NASA.

Absolute prompt-gamma yield measurements for ion beam therapy monitoring

NASA Astrophysics Data System (ADS)

Pinto, M.; Bajard, M.; Brons, S.; Chevallier, M.; Dauvergne, D.; Dedes, G.; De Rydt, M.; Freud, N.; Krimmer, J.; La Tessa, C.; Létang, J. M.; Parodi, K.; Pleskač, R.; Prieels, D.; Ray, C.; Rinaldi, I.; Roellinghoff, F.; Schardt, D.; Testa, E.; Testa, M.

2015-01-01

Prompt-gamma emission detection is a promising technique for hadrontherapy monitoring purposes. In this regard, obtaining prompt-gamma yields that can be used to develop monitoring systems based on this principle is of utmost importance since any camera design must cope with the available signal. Herein, a comprehensive study of the data from ten single-slit experiments is presented, five consisting in the irradiation of either PMMA or water targets with lower and higher energy carbon ions, and another five experiments using PMMA targets and proton beams. Analysis techniques such as background subtraction methods, geometrical normalization, and systematic uncertainty estimation were applied to the data in order to obtain absolute prompt-gamma yields in units of prompt-gamma counts per incident ion, unit of field of view, and unit of solid angle. At the entrance of a PMMA target, where the contribution of secondary nuclear reactions is negligible, prompt-gamma counts per incident ion, per millimetre and per steradian equal to (124 ± 0.7stat ± 30sys) × 10-6 for 95 MeV u-1 carbon ions, (79 ± 2stat ± 23sys) × 10-6 for 310 MeV u-1 carbon ions, and (16 ± 0.07stat ± 1sys) × 10-6 for 160 MeV protons were found for prompt gammas with energies higher than 1 MeV. This shows a factor 5 between the yields of two different ions species with the same range in water (160 MeV protons and 310 MeV u-1 carbon ions). The target composition was also found to influence the prompt-gamma yield since, for 300/310 MeV u-1 carbon ions, a 42% greater yield ((112 ± 1stat ± 22sys) × 10-6 counts ion-1 mm-1 sr-1) was obtained with a water target compared to a PMMA one.

Low-cost uncooled VOx infrared camera development

NASA Astrophysics Data System (ADS)

Li, Chuan; Han, C. J.; Skidmore, George D.; Cook, Grady; Kubala, Kenny; Bates, Robert; Temple, Dorota; Lannon, John; Hilton, Allan; Glukh, Konstantin; Hardy, Busbee

2013-06-01

The DRS Tamarisk® 320 camera, introduced in 2011, is a low cost commercial camera based on the 17 µm pixel pitch 320×240 VOx microbolometer technology. A higher resolution 17 µm pixel pitch 640×480 Tamarisk®640 has also been developed and is now in production serving the commercial markets. Recently, under the DARPA sponsored Low Cost Thermal Imager-Manufacturing (LCTI-M) program and internal project, DRS is leading a team of industrial experts from FiveFocal, RTI International and MEMSCAP to develop a small form factor uncooled infrared camera for the military and commercial markets. The objective of the DARPA LCTI-M program is to develop a low SWaP camera (<3.5 cm3 in volume and <500 mW in power consumption) that costs less than US $500 based on a 10,000 units per month production rate. To meet this challenge, DRS is developing several innovative technologies including a small pixel pitch 640×512 VOx uncooled detector, an advanced digital ROIC and low power miniature camera electronics. In addition, DRS and its partners are developing innovative manufacturing processes to reduce production cycle time and costs including wafer scale optic and vacuum packaging manufacturing and a 3-dimensional integrated camera assembly. This paper provides an overview of the DRS Tamarisk® project and LCTI-M related uncooled technology development activities. Highlights of recent progress and challenges will also be discussed. It should be noted that BAE Systems and Raytheon Vision Systems are also participants of the DARPA LCTI-M program.

Low-altitude photographic transects of the Arctic Network of National Park Units and Selawik National Wildlife Refuge, Alaska, July 2013

USGS Publications Warehouse

Marcot, Bruce G.; Jorgenson, M. Torre; DeGange, Anthony R.

2014-01-01

5. A Canon® Rebel 3Ti with a Sigma zoom lens (18–200 mm focal length). The Drift® HD-170 and GoPro® Hero3 cameras were secured to the struts and underwing for nadir (direct downward) imaging. The Panasonic® and Canon® cameras were each hand-held for oblique-angle landscape images, shooting through the airplanes’ windows, targeting both general landscape conditions as well as landscape features of special interest, such as tundra fire scars and landslips. The Drift® and GoPro® cameras each were set for time-lapse photography at 5-second intervals for overlapping coverage. Photographs from all cameras (100 percent .jpg format) were date- and time-synchronized to geographic positioning system waypoints taken during the flights, also at 5-second intervals, providing precise geotagging (latitude-longitude) of all files. All photographs were adjusted for color saturation and gamma, and nadir photographs were corrected for lens distortion for the Drift® and GoPro® cameras’ 170° wide-angle distortion. EXIF (exchangeable image file format) data on camera settings and geotagging were extracted into spreadsheet databases. An additional 1 hour, 20 minutes, and 43 seconds of high-resolution videos were recorded at 60 frames per second with the GoPro® camera along selected transect segments, and also were image-adjusted and corrected for lens distortion. Geotagged locations of 12,395 nadir photographs from the Drift® and GoPro® cameras were overlayed in a geographic information system (ArcMap 10.0) onto a map of 44 ecotypes (land- and water-cover types) of the Arctic Network study area. Presence and area of each ecotype occurring within a geographic information system window centered on the location of each photograph were recorded and included in the spreadsheet databases. All original and adjusted photographs, videos, geographic positioning system flight tracks, and photograph databases are available by contacting ascweb@usgs.gov.

How long is enough to detect terrestrial animals? Estimating the minimum trapping effort on camera traps

PubMed Central

Si, Xingfeng; Kays, Roland

2014-01-01

Camera traps is an important wildlife inventory tool for estimating species diversity at a site. Knowing what minimum trapping effort is needed to detect target species is also important to designing efficient studies, considering both the number of camera locations, and survey length. Here, we take advantage of a two-year camera trapping dataset from a small (24-ha) study plot in Gutianshan National Nature Reserve, eastern China to estimate the minimum trapping effort actually needed to sample the wildlife community. We also evaluated the relative value of adding new camera sites or running cameras for a longer period at one site. The full dataset includes 1727 independent photographs captured during 13,824 camera days, documenting 10 resident terrestrial species of birds and mammals. Our rarefaction analysis shows that a minimum of 931 camera days would be needed to detect the resident species sufficiently in the plot, and c. 8700 camera days to detect all 10 resident species. In terms of detecting a diversity of species, the optimal sampling period for one camera site was c. 40, or long enough to record about 20 independent photographs. Our analysis of evaluating the increasing number of additional camera sites shows that rotating cameras to new sites would be more efficient for measuring species richness than leaving cameras at fewer sites for a longer period. PMID:24868493

Development of a Compact & Easy-to-Use 3-D Camera for High Speed Turbulent Flow Fields

DTIC Science & Technology

2013-12-05

resolved. Also, in the case of a single camera system, the use of an aperture greatly reduces the amount of collected light. The combination of these...a study on wall-bounded turbulence [Sheng_2006]. Nevertheless, these techniques are limited to small measurement volumes, while maintaining a high...It has also been adapted to kHz rates using high-speed cameras for aeroacoustic studies (see Violato et al. [17, 18]. Tomo-PIV, however, has some

Microgravity

NASA Image and Video Library

2002-08-06

A student gets ready to catch a plastic tube carrying a small fluid bottle and a wireless video camera. As it arced through the air, the container was in free-fall -- just like astronauts in space -- and the TV camera broadcast images of how the fluid behaved. The activity was part of the Space Research and You education event held by NASA's Office of Biological and Physical Research on June 25, 2002, in Arlington, VA, to highlight the research that will be conducted on STS-107. (Digital camera image; no film original.

Gamma Knife irradiation method based on dosimetric controls to target small areas in rat brains

DOE Office of Scientific and Technical Information (OSTI.GOV)

Constanzo, Julie; Paquette, Benoit; Charest, Gabriel

2015-05-15

Purpose: Targeted and whole-brain irradiation in humans can result in significant side effects causing decreased patient quality of life. To adequately investigate structural and functional alterations after stereotactic radiosurgery, preclinical studies are needed. The purpose of this work is to establish a robust standardized method of targeted irradiation on small regions of the rat brain. Methods: Euthanized male Fischer rats were imaged in a stereotactic bed, by computed tomography (CT), to estimate positioning variations relative to the bregma skull reference point. Using a rat brain atlas and the stereotactic bregma coordinates obtained from CT images, different regions of the brainmore » were delimited and a treatment plan was generated. A single isocenter treatment plan delivering ≥100 Gy in 100% of the target volume was produced by Leksell GammaPlan using the 4 mm diameter collimator of sectors 4, 5, 7, and 8 of the Gamma Knife unit. Impact of positioning deviations of the rat brain on dose deposition was simulated by GammaPlan and validated with dosimetric measurements. Results: The authors’ results showed that 90% of the target volume received 100 ± 8 Gy and the maximum of deposited dose was 125 ± 0.7 Gy, which corresponds to an excellent relative standard deviation of 0.6%. This dose deposition calculated with GammaPlan was validated with dosimetric films resulting in a dose-profile agreement within 5%, both in X- and Z-axes. Conclusions: The authors’ results demonstrate the feasibility of standardizing the irradiation procedure of a small volume in the rat brain using a Gamma Knife.« less

Pre-clinical and Clinical Evaluation of High Resolution, Mobile Gamma Camera and Positron Imaging Devices

DTIC Science & Technology

2009-10-01

Field-of-View, Mobile PET/SPECT System for Bedside Environments: A Dynamic Cardiac Phantom Study using 99mTc and 18F- FDG . Presented at the American...using Tc-99m tracers and viability imaging using F- 18 tracers [3]-[7]. For cardiac F-18 imaging in a bedside environment, the 511 keV SPECT approach...SPECT system may have difficulty imaging subtle myocardial defects with F-18 tracers , but it may effectively image moderate to severe defects. The

Pre-clinical and Clinical Evaluation of High Resolution, Mobile Gamma Camera and Positron Imaging Devices

DTIC Science & Technology

2010-10-01

Downloaded on February 20,2010 at 10:55:59 EST from IEEE Xplore . Restrictions apply. STUDENSKI et al.: ACQUISITION AND PROCESSING METHODS FOR A BEDSIDE...February 20,2010 at 10:55:59 EST from IEEE Xplore . Restrictions apply. 208 IEEE TRANSACTIONS ON NUCLEAR SCIENCE, VOL. 57, NO. 1, FEBRUARY 2010 from the...59 EST from IEEE Xplore . Restrictions apply. STUDENSKI et al.: ACQUISITION AND PROCESSING METHODS FOR A BEDSIDE CARDIAC SPECT IMAGING SYSTEM 209

ARC-1986-A86-7032

NASA Image and Video Library

1986-01-24

P-29516 BW Range: 125, 000 kilometers (78,000 miles) Voyager 2's wide-angle camera captured this view of the outer part of the Uranian ring system just 11 minutes before passing though the ring plane. The resolution in this clear-filter view is slightly better than 9 km (6 mi). The brightest, outermost ring is known as epsilon. Interior to epsilon lie (from top) the newly discovered 10th ring of Uranus--designated 1986UR1 and barely visible here--and then the delta, gamma and eta rings.

Rise Time of the Simulated VERITAS 12 m Davies-Cotton Reflector

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Richard J.

The Very Energetic Radiation Imaging Telescope Array System (VERITAS) will utilise Imaging Atmospheric Cherenkov Telescopes (IACTs) based on a Davies-Cotton design with f-number f/1.0 to detect cosmic gamma-rays. Unlike a parabolic reflector, light from the Davies-Cotton does not arrive isochronously at the camera. Here the effect of the telescope geometry on signal rise-time is examined. An almost square-pulse arrival time profile with a rise time of 1.7 ns is found analytically and confirmed through simulation.

Filtered back-projection algorithm for Compton telescopes

DOEpatents

Gunter, Donald L [Lisle, IL

2008-03-18

A method for the conversion of Compton camera data into a 2D image of the incident-radiation flux on the celestial sphere includes detecting coincident gamma radiation flux arriving from various directions of a 2-sphere. These events are mapped by back-projection onto the 2-sphere to produce a convolution integral that is subsequently stereographically projected onto a 2-plane to produce a second convolution integral which is deconvolved by the Fourier method to produce an image that is then projected onto the 2-sphere.

Assessment of Non-Invasive Methods of Measuring Bone Repair in Naval Casualty Victims.

DTIC Science & Technology

1980-02-01

the pin-hole colurnator on a high resolution gamma camera. In addition, the pilot project was necessary to train new technicians who had been hired...after the loss of trained technicians in 1976. Finally, the project was under- taken to help define any problems with regards to radiation contamination...allograft was entirely normal and equivalent to its autogenous control except that its histologic rating was a Type II repair rather than a Type I. In

Imaging method for monitoring delivery of high dose rate brachytherapy

DOEpatents

Weisenberger, Andrew G; Majewski, Stanislaw

2012-10-23

A method for in-situ monitoring both the balloon/cavity and the radioactive source in brachytherapy treatment utilizing using at least one pair of miniature gamma cameras to acquire separate images of: 1) the radioactive source as it is moved in the tumor volume during brachytherapy; and 2) a relatively low intensity radiation source produced by either an injected radiopharmaceutical rendering cancerous tissue visible or from a radioactive solution filling a balloon surgically implanted into the cavity formed by the surgical resection of a tumor.

Displacement and deformation measurement for large structures by camera network

NASA Astrophysics Data System (ADS)

Shang, Yang; Yu, Qifeng; Yang, Zhen; Xu, Zhiqiang; Zhang, Xiaohu

2014-03-01

A displacement and deformation measurement method for large structures by a series-parallel connection camera network is presented. By taking the dynamic monitoring of a large-scale crane in lifting operation as an example, a series-parallel connection camera network is designed, and the displacement and deformation measurement method by using this series-parallel connection camera network is studied. The movement range of the crane body is small, and that of the crane arm is large. The displacement of the crane body, the displacement of the crane arm relative to the body and the deformation of the arm are measured. Compared with a pure series or parallel connection camera network, the designed series-parallel connection camera network can be used to measure not only the movement and displacement of a large structure but also the relative movement and deformation of some interesting parts of the large structure by a relatively simple optical measurement system.

Concentration and Velocity Gradients in Fluidized Beds

NASA Technical Reports Server (NTRS)

McClymer, James P.

2003-01-01

In this work we focus on the height dependence of particle concentration, average velocity components, fluctuations in these velocities and, with the flow turned off, the sedimentation velocity. The latter quantities are measured using Particle Imaging Velocimetry (PIV). The PIV technique uses a 1-megapixel camera to capture two time-displaced images of particles in the bed. The depth of field of the imaging system is approximately 0.5 cm. The camera images a region with characteristic length of 2.6 cm for the small particles and 4.7 cm. for the large particles. The local direction of particle flow is determined by calculating the correlation function for sub-regions of 32 x 32 pixels. The velocity vector map is created from this correlation function using the time between images (we use 15 to 30 ms). The software is sensitive variations of 1/64th of a pixel. We produce velocity maps at various heights, each consisting of 3844 velocities. We break this map into three vertical zones for increased height information. The concentration profile is measured using an expanded (1 cm diameter) linearly polarized HeNe Laser incident on the fluidized bed. A COHU camera (gamma=1, AGC off) with a lens and a polarizer images the transmitted linearly polarized light to minimize the effects of multiply scattered light. The intensity profile (640 X 480 pixels) is well described by a Gaussian fit and the height of the Gaussian is used to characterize the concentration. This value is compared to the heights found for known concentrations. The sedimentation velocity is estimated using by imaging a region near the bottom of the bed and using PIV to measure the velocity as a function of time. With a nearly uniform concentration profile, the time can be converted to height information. The stable fluidized beds are made from large pseudo-monodisperse particles (silica spheres with radii (250-300) microns and (425-500) microns) dispersed in a glycerin/water mix. The Peclet number is sufficiently large that Brownian motion of the particles can be ignored and the Reynolds number sufficiently small that particle inertia is negligible. A packed particle bed is used to randomize and disperse the flowing fluid introduced by a peristaltic pump. The bed itself is a rectangular glass cell 8 cm wide (x), 0.8 cm deep and a height of 30.5 cm (z). The depth of field of the camera is approximately 0.5 cm so depth information is averaged. Over flow fluid is returned to the reservoir making a closed loop system. In these experiments the particles form a sediment approximately 5.7 cm high with the pump off and expand to 22 cm with the pump on. For the smaller particles the pump velocity is .5 millimeters per second and 1.1 millimeters per second for the large particles. At this concentration the bed has a very well defined top where particle concentration rapidly drops to zero.