Sample records for sokal vasili roudenok

  1. A Rhetorical Perspective on the Sokal Hoax: Genre, Style, and Context

    ERIC Educational Resources Information Center

    Secor, Marie; Walsh, Lynda


    In 1996, New York University professor of physics Alan Sokal wrote a parody of an academic article he titled "Transgressing the Boundaries: Toward a Transformative Hermeneutics of Quantum Gravity." This parody escaped detection by the editors and was published in the journal "Social Text." Sokal outed his own hoax in the academic magazine "Lingua…

  2. Prognostic discrimination for early chronic phase chronic myeloid leukemia in imatinib era: comparison of Sokal, Euro, and EUTOS scores in Korean population.


    Yahng, Seung-Ah; Jang, Eun-Jung; Choi, Soo-Young; Lee, Sung-Eun; Kim, Soo-Hyun; Kim, Dong-Wook


    Beyond the conventional Sokal and Euro scores, a new prognostic risk classification, based on the European Treatment Outcome Study (EUTOS), has been developed to predict the outcome of treatment with tyrosine kinase inhibitors (TKI) in chronic myeloid leukemia (CML). In the present study, each risk score was validated by various endpoints in 206 Korean patients with early chronic-phase CML treated with up-front standard dose imatinib. In our analysis, all three scores were found to be valid. The 5-year event-free survival (EFS) was significantly discriminated using Sokal (P = 0.002), Euro (P = 0.003), and EUTOS (P = 0.029), with the worst probability by Euro high-risk (62 vs. 49 vs. 67 %) and better EFS in Sokal low-risk (89 vs. 86 vs. 82 %). Combining all scores identified 6 % of all patients having homogeneous high-risk with distinctively worse outcomes (5-year EFS of 41 %, cumulative complete cytogenetic response rate of 56 %, and cumulative major molecular response rate of 27 %), whereas the group of discordance in risk scores (60 %) had similar results to those of intermediate-risk groups of Sokal and Euro scores. Combining all risk scores for baseline risk assessment may be useful in clinical practice for identifying groups of patients who may benefit from treatment initiation with a more potent TKI among the currently available first-line TKIs.

  3. Prognostic and predictive implications of Sokal, Euro and EUTOS scores in chronic myeloid leukaemia in the imatinib era-experience from a tertiary oncology centre in Southern India.


    Kuntegowdanahalli, Lakshmaiah Chinnagiriyappa; Kanakasetty, Govind Babu; Thanky, Aditi Harsh; Dasappa, Lokanatha; Jacob, Linu Abraham; Mallekavu, Suresh Babu; Lakkavalli, Rajeev Krishnappa; Kadabur, Lokesh N; Haleshappa, Rudresha Antapura


    Chronic myeloid leukaemia (CML) is a myeloproliferative disorder. Over the years many prognostic models have been developed to better risk stratify this disease at baseline. Sokal, Euro, and EUTOS scores were developed in varied populations initially receiving various therapies. Here we try to identify their predictive and prognostic implication in a larger population of Indian patients with CML-CP (chronic phase) in the imatinib era.

  4. Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia.


    Christiansson, Lisa; Söderlund, Stina; Svensson, Emma; Mustjoki, Satu; Bengtsson, Mats; Simonsson, Bengt; Olsson-Strömberg, Ulla; Loskog, Angelica S I


    Immunotherapy (eg interferon α) in combination with tyrosine kinase inhibitors is currently in clinical trials for treatment of chronic myeloid leukemia (CML). Cancer patients commonly have problems with so called immune escape mechanisms that may hamper immunotherapy. Hence, to study the function of the immune system in CML is of interest. In the present paper we have identified immune escape mechanisms in CML with focus on those that directly hamper T cells since these cells are important to control tumor progression. CML patient samples were investigated for the presence of myeloid-derived suppressor cells (MDSCs), expression of programmed death receptor ligand 1/programmed death receptor 1 (PD-L1/PD-1), arginase 1 and soluble CD25. MDSC levels were increased in samples from Sokal high risk patients (p<0.05) and the cells were present on both CD34 negative and CD34 positive cell populations. Furthermore, expression of the MDSC-associated molecule arginase 1, known to inhibit T cells, was increased in the patients (p = 0.0079). Myeloid cells upregulated PD-L1 (p<0.05) and the receptor PD-1 was present on T cells. However, PD-L1 blockade did not increase T cell proliferation but upregulated IL-2 secretion. Finally, soluble CD25 was increased in high risk patients (p<0.0001). In conclusion T cells in CML patients may be under the control of different immune escape mechanisms that could hamper the use of immunotherapy in these patients. These escape mechanisms should be monitored in trials to understand their importance and how to overcome the immune suppression.

  5. 78 FR 51803 - Culturally Significant Objects Imported for Exhibition Determinations: “Vasily Kandinsky: From...

    Federal Register 2010, 2011, 2012, 2013, 2014


    ... to the Bauhaus, 1910-1925'' SUMMARY: Notice is hereby given of the following determinations: Pursuant...: From Blaue Reiter to the Bauhaus, 1910-1925,'' imported from abroad for temporary exhibition within...

  6. Formation of Polarized Beams in Chains of Dielectric Spheres and Cylinders

    DTIC Science & Technology


    Vasily Astratov Arash Darafsheh, Neda Mojaverian, Nicholaos I. Limberopoulos, Kenneth W. Allen, Anatole Lupu , Vasily N. Astratov 611102 c. THIS PAGE The...Allen,1 Anatole Lupu ,3 and Vasily N. Astratov1,2,5 1Department of Physics and Optical Science, Center for Optoelectronics and Optical Communications

  7. Values Education in the Soviet State: The Lasting Contribution of V. A. Sukhomlinsky

    ERIC Educational Resources Information Center

    Cockerill, Alan


    Vasily Sukhomlinsky (1918-1970) was arguably the most influential Soviet educator of the post-war period. He was a practising teacher, and from 1947 to 1970 was principal of a school in the Ukrainian village of Pavlysh. One of Sukhomlinsky's primary concerns was to inculcate in his students the values of compassion and service, combined with…

  8. Soils regulate and mitigate climate change

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background/Question/Methods: The interaction of soil science and ecology can be traced back to the origins of soil science as an independent discipline within the natural sciences. Vasili Dokuchaev, the founder of modern soil science, identified five soil forming factors: parent material, climate, o...

  9. Development of Reflection through Learning Activity

    ERIC Educational Resources Information Center

    Zuckerman, Galina


    What kind of developmental potential is present in elementary schoolchildren but hindered by the traditional type of education? Half a century ago Daniel El'konin and Vasili Davydov, the leaders of Russian Vygotskian educational psychology started answering this question. They suggested that reflection is a basic human ability and it can be…

  10. Low ABCB1 and high OCT1 levels play a favorable role in the molecular response to imatinib in CML patients in the community clinical practice.


    da Cunha Vasconcelos, Flavia; Mauricio Scheiner, Marcos Antonio; Moellman-Coelho, Arthur; Mencalha, André Luiz; Renault, Ilana Zalcberg; Rumjanek, Vivian Mary; Maia, Raquel Ciuvalschi


    Despite the favorable clinical evolution of patients with chronic myeloid leukemia (CML), resistance or intolerance to imatinib is present in approximately 35% of patients. Sokal score is a widely used risk factor, however efflux and influx transporters are provisional risk factors implicated in imatinib resistance. This study analyzed Sokal score, ABCB1, ABCG2 and OCT1 mRNA transporter expression levels as well as P-glycoprotein expression and efflux transporters activity to seek a possible correlation between these factors and the molecular response at 12 months from imatinib start as well as 8-year overall survival (OS). Low plus intermediate Sokal score correlated to optimal imatinib responses, as well as OS at 8-years, thus confirming the established role of Sokal score as a prognostic factor in CML patients. Low ABCB1 and high OCT1 mRNA levels were associated with an optimal molecular response, while the inverse levels were associated with non-responders (warning and failure) patients. Our results suggest that ABCB1 and OCT1 mRNA expressions may present biological relevance to identify responder and non-responder patients to imatinib treatment.

  11. Hierarchical Clustering: A Bibliography. Technical Report No. 1.

    ERIC Educational Resources Information Center

    Farrell, William T.

    "Classification: Purposes, Principles, Progress, Prospects" by Robert R. Sokal is reprinted in this document. It summarizes the principles of classification and cluster analysis in a manner which is of specific value to the Marine Corps Office of Manpower Utilization. Following the article is a 184 item bibliography on cluster analysis…

  12. Fitness and Health. Beginnings Workshop.

    ERIC Educational Resources Information Center

    Child Care Information Exchange, 2000


    Presents five articles on children's fitness and health: "Relaxation: Every Child's Right to Simply Be" (Patrice Thomas and Wendy Shepherd); "Infant Massage" (Carolyn Oleson); "Fitness and the Young Child" (James M. Poole); "Partners in Health: Helping Families Advocate for Their Children's Health Care" (Karen Sokal-Gutierrez); and "Preventing…

  13. Postmodernism, politics and religion

    NASA Astrophysics Data System (ADS)

    Anderson, Philip


    Alan Sokal really likes footnotes, which may have made him uniquely qualified as a hoaxer of "science studies". The original hoax, a purposely and wonderfully nonsensical paper about the epistemology of quantum gravity, appeared in 1996 in the cultural-studies journal Social Text, with the enthusiastic endorsement of its editorship of eminent postmodernists. There were 107 footnotes.

  14. A Probable Endocrine Basis for the Depression of Ketone Bodies during Infectious or Inflammatory State in Rats

    DTIC Science & Technology


    were maintained on a commerciel diet -- nals," as promulgated by the Committee on Care and Use of (Wayne Lab-Blox, Allied Mills, Inc., Chicago, IL...Mackreil and Sokal (26). However, in a fasted rat, a direct inhibitory effect of insulin on the hepatic ketogenic IUcapacity could not be vitro. This obser- a2o- ..C, IIL vation suggests an indirect role of insulin in inhibiting 0 106 VI ., hepatic ketogenic capacity.’ 0 104 HEAT

  15. Toward Combined Arms Warfare: A Survey of 20th-Century Tactics, Doctrine, and Organization

    DTIC Science & Technology


    He could and did conceive of trucked 46 s. entators . ed pos tion or arting tarding e elopment a ized arfare. ere s e ruth is usation, ill...Vasili 1. Chuikov, The Fall of Berlin, translated by Ruth Risch (New York, 1968), 30-33. See, f Ol? example, S. Alferov, "Wartime Experience...Korea, Winter of 1950-51, Operations Research Office Study ORO-R-13 ( Chevy Chase, MD, 19511, 6-7. Ibid., 128-31; Marshall, “CCF In the Attack (Part II

  16. The Mishin Diaries, a new significant primary source of space history information

    NASA Astrophysics Data System (ADS)

    Payson, Dmitry; Alifanov, Oleg; Moiseev, Ivan; Vick, Charles; Woods, David


    Vasily Mishin (1917-2001) was a prominent Russian engineer and scientist: one of the pioneers who made spaceflight a reality. In 2014 diaries that were maintained by Mishin from 1960 to 1974 (the Mishin Diaries) had been transcribed and published and can now serve as an extensive resource for first-hand historical information about that fascinating period of time. The original Diaries are now owned by the Perot Foundation and copies were generously provided by them to the Moscow Aviation Institute for this transcription project. The actual publication was made possible by Mishin's students, co-workers, family members as well as numerous spaceflight historians and enthusiasts.

  17. Compilation of 1991 Annual Reports of the Navy ELF Communications Systems Ecological Monitoring Program

    DTIC Science & Technology


    ic 1T T3aC IT Ih nfgRlhC IT Figure 2. Locations of control (Cl to CS) and treatment (Ti to T5) transects in3 Michigan. I -8-I (Table 1). Several 500-m...blind: the making of EMF policy. Science 240:23-25. I Sokal, R.R., and N.L. Oden. 1978. Spatial autocorrelation in biology. 1. Methodology. Biol. J...increased by one-thir" with this site. Those energies could be used elsewhere, and reduced funding makes reasonable decisions associated with reduced

  18. An Underdiscussed Aspect of Chomsky (1959)

    PubMed Central

    Adelman, Barry Eshkol


    Chomsky's (1959) review of Skinner's (1957) Verbal Behavior has been influential and attributed with a role in the cognitive revolution. However, while counter reviews from within behavior analysis have noted that Chomsky misunderstood the subject matter, certain aspects of his scholarship have been underdiscussed. This includes several instances where Chomsky misquotes Skinner or takes his quotes out of context. Similar to the findings of Sokal (1996a, 1996b), it is speculated that the problems with Chomsky were overlooked by cognitive psychologists because his general outlook was accepted. Implications for the editorial review process are discussed. PMID:22477378

  19. An underdiscussed aspect of chomsky (1959).


    Adelman, Barry Eshkol


    Chomsky's (1959) review of Skinner's (1957)Verbal Behavior has been influential and attributed with a role in the cognitive revolution. However, while counter reviews from within behavior analysis have noted that Chomsky misunderstood the subject matter, certain aspects of his scholarship have been underdiscussed. This includes several instances where Chomsky misquotes Skinner or takes his quotes out of context. Similar to the findings of Sokal (1996a, 1996b), it is speculated that the problems with Chomsky were overlooked by cognitive psychologists because his general outlook was accepted. Implications for the editorial review process are discussed.

  20. 110th Anniversary of the Engelhardt Astronomical Observatory

    NASA Astrophysics Data System (ADS)

    Nefedyev, Y.


    The Engelhardt Astronomical Observatory (EAO) was founded in September 21, 1901. The history of creation of the Engelhard Astronomical Observatory was begun in 1897 with transfer a complimentary to the Kazan University of the unique astronomical equipment of the private observatory in Dresden by known astronomer Vasily Pavlovichem Engelgardt. Having stopped astronomical activity owing to advanced years and illnesses Engelgardt has decided to offer all tools and library of the Astronomical observatory of the Kazan University. Vasily Pavlovich has put the first condition of the donation that his tools have been established as soon as possible and on them supervision are started. In 1898 the decree of Emperor had been allocated means and the ground for construction of the Astronomical observatory is allocated. There is the main historical telescope of the Engelhard Astronomical Observatory the 12-inch refractor which was constructed by English master Grubbom in 1875. The unique tool of the Engelhard Astronomical Observatory is unique in the world now a working telescope heliometer. It's one of the first heliometers, left workshops Repsolda. It has been made in 1874 and established in Engelgardt observatory in 1908 in especially for him the constructed round pavilion in diameter of 3.6 m. Today the Engelhard Astronomical Observatory is the only thing scientifically - educational and cultural - the cognitive astronomical center, located on territory from Moscow up to the most east border of Russia. Currently, the observatory is preparing to enter the protected UNESCO World Heritage List.

  1. The Hasford Score May Predict Molecular Response in Chronic Myeloid Leukemia Patients: A Single Institution Experience

    PubMed Central

    Jaźwiec, Bożena; Haus, Olga; Urbaniak-Kujda, Donata; Kapelko-Słowik, Katarzyna; Wróbel, Tomasz; Lonc, Tomasz; Sawicki, Mateusz; Mędraś, Ewa; Kaczmar-Dybko, Agnieszka; Kuliczkowski, Kazimierz


    The Sokal, Hasford, and EUTOS scores were established in different treatment eras of chronic myeloid leukemia (CML). None of them was reported to predict molecular response. In this single center study we tried to reevaluate the usefulness of three main scores in TKI era. The study group included 88 CML patients in first chronic phase treated initially with standard imatinib dose. All of them achieved major molecular response (MMR) in time points defined by European LeukemiaNet (ELN). 42 patients lost MMR in a median time of 47 months and we found a significant difference in MMR maintenance between intermediate-risk (IR) and low-risk (LR) patients assessed by Hasford score. All 42 patients were switched to second-generation TKI (2G-TKI) treatment. At 18 months of 2G-TKI therapy we have still found a significant difference in BCR-ABL transcript levels and MMR rate between IR and LR groups. We did not find any of the described differences discriminating patients by Sokal or EUTOS score. In this retrospective single center analysis we found Hasford score to be useful in predicting molecular response in first chronic phase of CML patients. PMID:27818567

  2. Archeointensities in Greece during the Neolithic period: New insights into material selection and secular variation curve

    NASA Astrophysics Data System (ADS)

    Fanjat, G.; Aidona, E.; Kondopoulou, D.; Camps, P.; Rathossi, C.; Poidras, T.


    Numerous archeomagnetic studies have provided high quality data for both the direction and the intensity of the geomagnetic field, essentially in Europe for the last 10 millennia. In particular, Greece supplies a lot of archeological materials due to its impressive cultural heritage and volcanic activity, so that numerous data have been obtained from burnt clays or historical lava flows. The most recent Greek secular variation curves are available for the last 8 millennia for the intensity and the last 6 millennia for the direction. Nevertheless, the coverage still presents several gaps for periods older than 2500 BC. In an effort to complete the Greek curve and extend it to older times, we present the archeointensity results from three Neolithic settlements in Northern Greece. The samples are of two different natures: burnt structures from Avgi (5250 ± 150 BC) and Vasili (4800 ± 200 BC), as well as ceramics from Dikili Tash (4830 ± 80 BC) and Vasili (4750 ± 250 BC). The samples have been subjected to standard rock magnetic analyses in order to estimate the thermal stability and the domain state of the magnetic carriers before archeointensity measurements. Surprisingly, very few ceramic samples provided reliable archeointensities whereas samples from burnt structures presented a very good success rate. Complementary studies showed that a detailed examination of the matrix color, following archeological information and classification standards can be a decisive test for pre-selection of sherds. In spite of these unsuccessful measurements from ceramics, we obtained an intensity value of 73.5 ± 1.1 μT for Dikili Tash, a higher value than the other data obtained in the same area, during the same period. However we do not have evidences for a technical artefact during the experiment. The burnt structures yielded two reliable archeointensities of 36.1 ± 1.8 μT and 46.6 ± 3.4 μT for Avgi and Vasili, respectively. Finally, we achieved a new archeomagnetic dating

  3. Comittees

    NASA Astrophysics Data System (ADS)


    Fritz Caspers (CERN, Switzerland), Michel Chanel (CERN, Switzerland), Håkan Danared (MSL, Sweden), Bernhard Franzke (GSI, Germany), Manfred Grieser (MPI für Kernphysik, Germany), Dieter Habs (LMU München, Germany), Jeffrey Hangst (University of Aarhus, Denmark), Takeshi Katayama (RIKEN/Univ. Tokyo, Japan), H.-Jürgen Kluge (GSI, Germany), Shyh-Yuan Lee (Indiana University, USA), Rudolf Maier (FZ Jülich, Germany), John Marriner (FNAL, USA), Igor Meshkov (JINR, Russia), Dieter Möhl (CERN, Switzerland), Vasily Parkhomchuk (BINP, Russia), Robert Pollock (Indiana University), Dieter Prasuhn (FZ Jülich, Germany), Dag Reistad (TSL, Sweden), John Schiffer (ANL, USA), Andrew Sessler (LBNL, USA), Alexander Skrinsky (BINP, Russia), Markus Steck (GSI, Germany), Jie Wei (BNL, USA), Andreas Wolf (MPI für Kernphysik, Germany), Hongwei Zhao (IMP, People's Rep. of China).

  4. Final Scientific EFNUDAT Workshop




    The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive.EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluationCross section measurementsExperimental techniquesUncertainties and covariancesFission propertiesCurrent and future facilities  International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco CalvianiSamuel AndriamonjeEric BerthoumieuxCarlos GuerreroRoberto LositoVasilis Vlachoudis Workshop Assistant: Géraldine Jean

  5. The Dokuchaev hypothesis as a basis for predictive digital soil mapping (on the 125th anniversary of its publication)

    NASA Astrophysics Data System (ADS)

    Florinsky, I. V.


    Predictive digital soil mapping is widely used in soil science. Its objective is the prediction of the spatial distribution of soil taxonomic units and quantitative soil properties via the analysis of spatially distributed quantitative characteristics of soil-forming factors. Western pedometrists stress the scientific priority and principal importance of Hans Jenny's book (1941) for the emergence and development of predictive soil mapping. In this paper, we demonstrate that Vasily Dokuchaev explicitly defined the central idea and statement of the problem of contemporary predictive soil mapping in the year 1886. Then, we reconstruct the history of the soil formation equation from 1899 to 1941. We argue that Jenny adopted the soil formation equation from Sergey Zakharov, who published it in a well-known fundamental textbook in 1927. It is encouraging that this issue was clarified in 2011, the anniversary year for publications of Dokuchaev and Jenny.

  6. Irreversible Markov chain Monte Carlo algorithm for self-avoiding walk

    NASA Astrophysics Data System (ADS)

    Hu, Hao; Chen, Xiaosong; Deng, Youjin


    We formulate an irreversible Markov chain Monte Carlo algorithm for the self-avoiding walk (SAW), which violates the detailed balance condition and satisfies the balance condition. Its performance improves significantly compared to that of the Berretti-Sokal algorithm, which is a variant of the Metropolis-Hastings method. The gained efficiency increases with spatial dimension (D), from approximately 10 times in 2D to approximately 40 times in 5D. We simulate the SAW on a 5D hypercubic lattice with periodic boundary conditions, for a linear system with a size up to L = 128, and confirm that as for the 5D Ising model, the finite-size scaling of the SAW is governed by renormalized exponents, v* = 2/ d and γ/ v* = d/2. The critical point is determined, which is approximately 8 times more precise than the best available estimate.

  7. Consistency Test between Scoring Systems for Predicting Outcomes of Chronic Myeloid Leukemia in a Saudi Population Treated with Imatinib

    PubMed Central


    Inconsistency in prognostic scores occurs where two different risk categories are applied to the same chronic myeloid leukemia (CML) patient. This study evaluated common scoring systems for identifying risk groups based on patients' molecular responses to select the best prognostic score when conflict prognoses are obtained from patient profiles. We analyzed 104 patients diagnosed with CML and treated at King Abdulaziz Medical City, Saudi Arabia, who were monitored for major molecular response (achieving a BCR-ABL1 transcript level equal to or less than 0.1%) by Real-Time Quantitative Polymerase Chain Reaction (RQ-PCR), and their risk profiles were identified using Sokal, Hasford, EUTOS, and ELTS scores based on the patients' clinical and hematological parameters at diagnosis. Our results found that the Hasford score outperformed other scores in identifying risk categories for conflict groups, with an accuracy of 63%. PMID:28286862

  8. Archeointensities during the Neolithic period in Greece: new data to constraint the secular variation curves

    NASA Astrophysics Data System (ADS)

    Fanjat, G.; Aidona, E.; Camps, P.; Poidras, T.; Kondopoulou, D.


    Archaeomagnetism has been continuously developed over the last three decades. Backed archaeological features such as pottery, kilns or burnt structures, provide reliable data as they usually carry a strong and stable thermo-remanent magnetization acquired during the last firing. Numerous studies have provided high quality data for both the direction and intensity of the geomagnetic field essentially in Europe (e. g. compilations Genevey et al 2008, G3, Kovacheva et al, 2009, G3). In particular, Greece provides a lot of archaeological materials and numerous data are available (e. g. Aitken et al 1984, PEPI, Aitken et al 1989, PEPI, De Marco et al, 2008, Phys. Chem. Earth) from archaeomagnetic features or historical lava flows (Spassov et al, 2010, G3). The Greek secular variation curves (SVCs) are available for the last 8 millennia for the intensity and the last 6 millenia for the direction. Nevertheless, the coverage of the archaeological periods remains with several gaps for periods older than 2500 BC (Genevey et al, 2008, G3 and Kovacheva et al, 2009, G3). In this study, we present paleointensity results from Neolithic settlements in Northern Greece. Samples have been collected from four different archaeological sites: burnt structures and ceramics in Avgi (Kastoria, 5400-5100 B.C.) and Vasili (Farsala, 6000 B.C.), one kiln with the associated ceramics from Sossandra (Aridaia, 5000-4600 B.C.) and one ceramic collection from Dikili Tash (Kavala, 4800 B.C.). The samples have been subjected to a standard magnetic analysis in order to define the stability of the magnetic carriers and fulfil all the required criteria for the estimation of the palaeointensity. We obtained two reliable palaeointensities for the Avgi and Vasili sites of 38 and 48 μT respectively and a high mean paleointensity value arround 85 μT for the Dikili Tash site. These results are compared with the SVCs from neighbouring countries as well as with recent compilations and global models. We

  9. Combination of White Blood Cell Count at Presentation With Molecular Response at 3 Months Better Predicts Deep Molecular Responses to Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Patients.


    Qin, Ya-Zhen; Jiang, Qian; Jiang, Hao; Lai, Yue-Yun; Zhu, Hong-Hu; Liu, Yan-Rong; Jiang, Bin; Huang, Xiao-Jun


    The aim of this study was to evaluate the impact of white blood cell (WBC) counts at presentation on the achievement of deep molecular response.A total of 362 newly diagnosed chronic-phase chronic myeloid leukemia patients (CML-CP) receiving 400 mg/day imatinib were serially monitored for a median of 36 months (range 6-115).Patients showing an optimal response at 3, 6, and 12 months as defined by the 2013 European LeukemiaNet recommendations had significantly lower WBC counts at presentation than those showing nonoptimal responses (all P < 0.0001). Among the cutoff values with a similar Youden index, 150 × 10E9/L (abbreviated WBC > 150) was selected to identify the greatest amount of patients with the potential to achieve a sustained molecular response of 4.5 (MR4.5). Regardless of whether the Sokal risk score was included, the BCR-ABL value at 3 months, WBC counts at presentation, hemoglobin levels, and sex were the common independent predictors for an MR4.5, with the former 2 presenting the highest hazard risk. Low Sokal risk scores did not independently predict the achievement of an MR4.5. Patients with concurrent WBC > 150 and BCR-ABL(IS) ≤ 10% had a similar incidence of 4-year MR4.5 compared with patients with concurrent WBC ≤ 150 and BCR-ABL(IS) > 10% and concurrent WBC > 150 and BCR-ABL(IS) > 10% (13.5% vs 13.2% vs 8.8%, P = 0.47), and all of these values were significantly lower than the values for patients with concurrent WBC ≤ 150 and BCR-ABL(IS) ≤ 10% (55.0%, all P < 0.0001). Patients with concurrent WBC ≤ 150 and BCR-ABL(IS) ≤ 10% had better 4-year event-free survival rates, progression-free survival rates, and overall survival rates compared with patients with WBC > 150 or BCR-ABL(IS) > 10%. The combination of WBC count at presentation and BCR-ABL(IS) at 3 months provides improved predictions of deep molecular response in imatinib-treated CML-CP patients. Therefore, the WBC count at presentation might be used to

  10. Pattern of chronic myeloid leukemia in the imatinib era in a Sub-Saharan African setting.


    Faye, Blaise Felix; Dieng, Nata; Seck, Moussa; Gadji, Macoura; Gueye, Youssou Bamar; Sy, Diariatou; Toure, Sokhna Aissatou; Sall, Abibatou; Toure, Awa Oumar; Dieye, Tandakha Ndiaye; Diop, Saliou


    Chronic myeloid leukemia (CML) is an orphan disease in Africa because of the inaccessibility to specific treatment and the high cost of diagnosis and monitoring patients. The aim of this study was to report CML treatment response in a developing country in the tyrosine kinase inhibitor era. We conducted a longitudinal study of our cohort of CML patients. Socio-demographic, diagnosis, therapeutic, and treatment response parameters were studied. Sokal score, disease phase at diagnosis, delay from diagnosis to treatment, and treatment response were analyzed for their impact on survival. Fifty-five patients with a diagnosis of CML and who received treatment with imatinib for a minimum of 3 months were included in this study. Median follow-up was 170 patient-years. The sex ratio (M/F) was 1.62 and median age at diagnosis was 42 years. At diagnosis, 85.5 % of the patients were in chronic phase (CP), 12.7 % in accelerated phase (AP), and 1.8 % in blast crisis (BC). Sokal risk score distribution was as follows: low risk 29.8 %, intermediate risk 38.3 %, and high risk 31.9 %. Median time from first symptoms to first medical visit was 6.2 months and median time from first medical visit to cytogenetic and or molecular confirmation was 12.4 months. Mean delay time from first medical visit to imatinib initiation was 12.5 months (95 % CI 6.3-18.7). The complete hematologic response (CHR) at 3 months, the major cytogenetic response (MCR) at 12 months, and the major molecular response (MMR) at 24 months were respectively 82.4, 75, and 25 %. The 2-year overall survival rate was 81 %. Advanced phase at the diagnosis, discontinuation of imatinib therapy over 15 % of the time, lack of CHR at 3 months, lack of MCR at 12 months, and progression of the disease during imatinib therapy were associated with a risk of death (p ≤ 0.05). Our data confirm the improved prognosis of CML treated with imatinib in the setting of a developing country. However, response rates

  11. Real time assessment of the 15 July 2009 New Zealand tsunami

    NASA Astrophysics Data System (ADS)

    Uslu, Burak; Power, William; Greensdale, Dianne; Titov, Vasily


    On the 15th July 2009 a Mw 7.6 earthquake occurred off the coast of Fiordland in the South Island of New Zealand, about 1200 km from Auckland, New Zealand, 1500 km from Hobart, Tasmania and 1800 km from Sydney, Australia. A tsunami was generated and an initial warning issued by the PTWC. The Centre for Australian Weather and Climate issued its first tsunami warning for coastal regions of eastern Australia and New Zealand 24 minutes after the earthquake. By serendipitous coincidence, the earthquake struck while the International Tsunami Symposium was in session in Novosibirsk Russia. This provided the opportunity to test, in real-time, several tsunami warning systems in front of attending scientists (Schiermeier, 2009). NOAA Center for Tsunami Research, Pacific Tsunami Warning Center, GNS Science, and Centre for Australian Weather and Climate scientists were present at the symposium and worked together. Vasily Titov showed "live" NOAA's methodology (Bernard et al, 2006) to assess the tsunami potential and, in consultation with colleagues, provided warning guidance, and the warning was eventually canceled. We discuss how the forecast was done and how accurate the initial determination was. References Bernard E.N. et al., 2006, Tsunami: scientific frontiers, mitigation, forecasting and policy implications, Phil. Trans. R. Soc. A, 364:1989-2007; doi:10.1098/rsta.2006.1809 Schiermeier, Q., 2009, Tsunami forecast in real time, Published online 16 July 2009 | Nature | doi:10.1038/news.2009.702

  12. Synaesthesia, the arts and creativity: a neurological connection.


    Mulvenna, Catherine M


    For over 100 years the link between synaesthesia and the arts has attracted controversy. This has been spurred by the production of auditory, literary and visual art by famous individuals who report experiences synonymous with the neurological condition. Impressive protagonists in this discussion include Arthur Rimbaud, Charles Baudelaire, Vasily Kandinsky, Vladimir Nabokov, Alexander Scriabin, Olivier Messiaen and David Hockney. Interdisciplinary debates have concerned whether synaesthesia can actively contribute to an artist's ability, whether it is a driving force or a mere idiosyncratic quirk and whether, fundamentally, it is a distinct idiopathic condition or an unusual metaphorical description of normal perception. Recent psychological and neuroscientific evidence offers a new level to the debate. Coherent patterns of a neural basis of synaesthesia have been confirmed with high spatial resolution brain imaging techniques and the link with the arts is transpiring to be more than superficial or coincidental. Moreover, the neural distinction of the synaesthete brain may prove to be a window into a neural basis of creative cognition, and therefore conducive to the expression of creativity in various media.

  13. The methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism increases the risk of developing chronic myeloid leukemia-a case-control study.


    Bănescu, Claudia; Iancu, Mihaela; Trifa, Adrian P; Macarie, Ioan; Dima, Delia; Dobreanu, Minodora


    The methylenetetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C polymorphisms are associated with variations in folate levels, a phenomenon linked to the development of various malignancies. The aim of this study was to investigate the influence of the 677 C>T and 1298 A>C polymorphisms in the MTHFR gene on the risk of developing chronic myeloid leukemia (CML). Our study included 151 patients with CML and 305 controls. The MTHFR 677 C>T and 1298 A>C polymorphisms were investigated by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and allele-specific PCR techniques. The CT and TT genotypes of the MTHFR 677 C>T polymorphism were associated with an increased risk of developing CML (odds ratio (OR) = 1.556, 95% confidence interval (CI) = 1.017-2.381, p value = 0.041, and OR = 1.897, 95% CI = 1.046-3.44, p value = 0.035, respectively). No association was observed between the prognostic factors (blasts, basophils, additional chromosomal abnormalities, EUTOS score, Sokal and Hasford risk groups) and the MTHFR 677 C>T and 1298 A>C variant genotypes in CML patients. Our study shows that the MTHFR 677 C>T polymorphism is significantly associated with the risk of CML in Romanian patients.

  14. [Molecular mechanisms in the resistance of CML stem cells to tyrosine kinase inhibitors and novel targets for achieving a cure].


    Tanaka, Hirokazu; Hirase, Chikara; Matsumura, Itaru


    Tyrosine kinase inhibitors (TKIs) have dramatically improved the clinical outcomes of patients with chronic myeloid leukemia (CML) in the chronic phase. However, even if these patients achieve and maintain marked molecular responses such as a complete molecular response (BCR-ABL/ABL≤0.032% by international scale), discontinuation of TKI treatment results in early molecular relapse in most cases. Although several factors such as the Sokal score and the duration of TKI treatment have been identified as being related to treatment-free remission (TFR), identification of more definite factors or clinical conditions that would enable us to select patients who can maintain TFR is required. Relapse after TKI discontinuation is considered to be attributable to CML stem cells surviving even in patients who maintain marked molecular responses. A number of in vitro experiments have shown that TKI by itself cannot kill CML stem cells. Also, CML stem cells are resistant to TKI in a manner dependent on self-renewal factors (Hh, Wnt/β-catenin), cell cycle regulators (PML), metabotropic factors (FOXO3, Alox5), and adhesion molecules (CXCR4). In addition, surface markers specific for CML stem cells such as IL-1RAP and CD26 have been identified. New therapeutic strategies targeting these molecules in combination with TKI hold promise of achieving a more effective strategy for curing CML.

  15. The characterisation of Bordetella/Alcaligenes-like organisms and their effects on turkey poults and chicks.


    Varley, J


    Eight isolates of the Bordetella or Alcaligenes-like organisms associated with turkey rhino-tracheitis were examined. Five of these isolates had been recovered from the United Kingdom and three were foreign isolates. Four of the UK isolates came from flocks with mild respiratory disease. The fifth isolate came from birds with no respiratory signs and this appears to be the first report of the recovery of Bordetella/Alcaligenes from apparently normal turkeys. The field isolates and type strains Alcaligenes faecalis NCTC 415 and Bordetella bronchiseptica NCTC 452 were characterised by biochemical tests, but these did not include any electrophoresis or nucleic acid studies. Cluster analysis using the group average method and the similarly coefficient of Sokal and Sneath indicated that all the strains were distinct from Alcaligenes faecalis but were quite closely related to Bordetella bronchiseptica. Each field isolate was used to infect separate groups of day-old turkey poults and chicks, and each group contained birds which were experimentally infected and others which were in-contact. Observations were made over a 32-day period. In turkey poults, some of the isolates induced severe respiratory disease and mortality, and others very little or none. The UK isolates were less pathogenic than the foreign isolates. It was not possible to correlate the pathogenicity of the isolates for turkey poults with their biochemical characteristics. Chicks infected with two of the eight isolates showed slight respiratory signs, but there was no significant mortality.

  16. Graphical representations and cluster algorithms I. Discrete spin systems

    NASA Astrophysics Data System (ADS)

    Chayes, L.; Machta, J.


    Graphical representations similar to the FK representation are developed for a variety of spin-systems. In several cases, it is established that these representations have (FKG) monotonicity properties which enables characterization theorems for the uniqueness phase and the low-temperature phase of the spin system. Certain systems with intermediate phases and/or first-order transitions are also described in terms of the percolation properties of the representations. In all cases, these representations lead, in a natural fashion, to Swendsen-Wang-type algorithms. Hence, at least in the above-mentioned instances, these algorithms realize the program described by Kandel and Domany, Phys. Rev. B 43 (1991) 8539-8548. All of the algorithms are shown to satisfy a Li-Sokal bound which (at least for systems with a divergent specific heat) implies critical slowing down. However, the representations also give rise to invaded cluster algorithms which may allow for the rapid simulation of some of these systems at their transition points.

  17. Plasmid and restriction endonuclease patterns in Pasteurella multocida isolated from a swine pyramid.


    Rúbies, Xavier; Casal, Jordi; Pijoan, Carlos


    Restriction endonuclease analysis (REA) and plasmid profile were used to study the epidemiology of Pasteurella multocida in a swine pyramid structure. The studied pyramid was comprised of a group of 12 swine farrow-to-finish farms related by unidirectional animal movement. P. multocida isolates were obtained from the lungs of 275 slaughtered pigs. Serotyping was performed by hyaluronidase sensitivity test and toxicity was investigated by the ELISA test. HpaII was used to cleave the P. multocida extracted DNA. REA patterns relationships were studied using the Sokal-Michener coefficients, and the dendrogram was built using the UPGMA system. The 218 P. multocida isolates obtained were distributed in 17 REA patterns. In 9 of the 12 farms studied only 2-3 REA patterns were detected, with one clearly predominant pattern. The 81 strains with plasmids were assigned to six plasmid profiles. REA and plasmid profiles proved to be good epidemiological tools for identifying different strains of P. multocida with the same phenotype.

  18. DNA hybridization, cladistics, and the phylogeny of phalangerid marsupials.


    Springer, M S; Kirsch, J A; Aplin, K; Flannery, T


    Single-copy DNA/DNA hybridization experiments and numerical cladistic analyses of anatomical characters were used to investigate relationships among nine phalangerid (Marsupialia) species from four different genera. Both rate-dependent and rate-independent analyses of molecular data indicate that species of Trichosurus from one clade and that Strigocuscus, Phalanger, and Spilocuscus form a second. Within the latter group, Spilocuscus is excluded from a Strigocuscus-Phalanger clade, which, in turn, is not fully resolved on a jackknife strict consensus tree. Minimum-length Dollo, Wagner, and Camin-Sokal parisomy trees based on 35 anatomical characters, in contrast, suggest placement of Strigocuscus with Trichosurus rather than with Spilocuscus and Phalanger. However, there are two derived characters that support the alternative arrange of Strigocuscus with Spilocuscus and Phalanger and one character that further unites Strigocuscus and Phalanger. Thus, DNA hybridization results are not inconsistent with the distribution of derived character states among anatomical characters, only with minimum-length trees based on character data.

  19. Dynamic and static properties of the invaded cluster algorithm

    NASA Astrophysics Data System (ADS)

    Moriarty, K.; Machta, J.; Chayes, L. Y.


    Simulations of the two-dimensional Ising and three-state Potts models at their critical points are performed using the invaded cluster (IC) algorithm. It is argued that observables measured on a sublattice of size l should exhibit a crossover to Swendsen-Wang (SW) behavior for l sufficiently less than the lattice size L, and a scaling form is proposed to describe the crossover phenomenon. It is found that the energy autocorrelation time τɛ(l,L) for an l×l sublattice attains a maximum in the crossover region, and a dynamic exponent zIC for the IC algorithm is defined according to τɛ,max~LzIC. Simulation results for the three-state model yield zIC=0.346+/-0.002, which is smaller than values of the dynamic exponent found for the SW and Wolff algorithms and also less than the Li-Sokal bound. The results are less conclusive for the Ising model, but it appears that zIC<0.21 and possibly that τɛ,max~ln L so that zIC=0-similar to previous results for the SW and Wolff algorithms.

  20. STS-84 Mission Specialist Carlos I. Noriega in white room

    NASA Technical Reports Server (NTRS)


    KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Carlos I. Noriega prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

  1. STS-84 Mission Specialist Elena V. Kondakova in white room

    NASA Technical Reports Server (NTRS)


    KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Elena V. Kondakova prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

  2. STS-84 Commander Charles J. Precourt in white room

    NASA Technical Reports Server (NTRS)


    KENNEDY SPACE CENTER, FLA. -- STS-84 Commander Charles J. Precourt prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

  3. Oral Histories in Meteoritics and Planetary Science - XX: Dale Cruikshank

    NASA Astrophysics Data System (ADS)

    Sears, Derek W. G.


    In this interview, Dale Cruikshank (Fig. 1) explains how as an undergraduate at Iowa State University he was a summer student at Yerkes Observatory where he assisted Gerard Kuiper in work on his Photographic Lunar Atlas. Upon completing his degree, Dale went to graduate school at the University of Arizona with Kuiper where he worked on the IR spectroscopy of the lunar surface. After an eventful 1968 trip to Moscow via Prague, during which the Soviets invaded Czechoslovakia, Dale assumed a postdoc position with Vasili Moroz at the Sternberg Astronomical Institute and more observational IR astronomy. Upon returning to the United States and after a year at Arizona, Dale assumed a position at the University of Hawai'i that he held for 17 years. During this period Dale worked with others on thermal infrared determinations of the albedos of small bodies beyond the asteroid Main Belt, leading to the recognition that low-albedo material is prevalent in the outer solar system that made the first report of complex organic solids on a planetary body (Saturn's satellite Iapetus). After moving to Ames Research Center, where he works currently, he continued this work and became involved in many outer solar system missions. Dale has served the community through his involvement in developing national policies for science-driven planetary exploration, being chair of the DPS 1990-1991 and secretary/treasurer for 1982-1985. He served as president of Commission 16 (Physics of Planets) of the IAU (2001-2003). He received the Kuiper prize in 2006.

  4. Relationships in Ananas and other related genera using chloroplast DNA restriction site variation.


    Duval, M F; Buso, G S C; Ferreira, F R; Noyer, J L; Coppens d'Eeckenbrugge, G; Hamon, P; Ferreira, M E


    Chloroplast DNA (cpDNA) diversity was examined using PCR-RFLP to study phylogenetic relationships in Ananas and related genera. One hundred fifteen accessions representing the seven Ananas species and seven other Bromelioideae including the neighboring monospecific genus Pseudananas, two Pitcairnioideae, and one Tillandsioideae were included in the study. Eight primers designed from cpDNA were used for generating fragments. Restriction by 18 endonucleases generated 255 variable fragments. Dissimilarities were calculated from the resulting matrix using the Sokal and Michener index and the neighbor-joining method was used to reconstruct the diversity tree. Phylogenetic reconstruction was attempted using Wagner parsimony. Phenetic and cladistic analyses gave consistent results. They confirm the basal position of Bromelia in the Bromelioideae. Ananas and Pseudananas form a monophyletic group, with three strongly supported sub-groups, two of which are geographically consistent. The majority of Ananas parguazensis accessions constitute a northern group restricted to the Rio Negro and Orinoco basins in Brazil. The tetraploid Pseudananas sagenarius joins the diploid Ananas fritzmuelleri to constitute a southern group. The third and largest group, which includes all remaining species plus some accessions of A. parguazensis and intermediate phenotypes, is the most widespread and its distribution overlaps those of the northern and southern groups. Ananas ananassoides is dominant in this sub-group and highly variable. Its close relationship to all cultivated species supports the hypothesis that this species is the wild ancestor of the domesticated pineapple. The data indicate that gene flow is common within this group and scarcer with both the first and second groups. Comparison of cpDNA data with published genomic DNA data point to the hybrid origin of Ananas bracteatus and support the autopolyploidy of Pseudananas. The Ananas-Pseudananas group structure and distribution are

  5. Low educational level but not low income impairs the achievement of cytogenetic remission in chronic myeloid leukemia patients treated with imatinib in Brazil

    PubMed Central

    Rego, Monica Napoleão Fortes; Metze, Konradin; Lorand-Metze, Irene


    OBJECTIVES: In Brazil, imatinib mesylate is supplied as the first-line therapy for chronic myeloid leukemia in the chronic phase through the public universal healthcare program, Sistema Único de Saúde (SUS). We studied the socio-demographic factors that influenced therapy success in a population in the northeast region of Brazil. METHODS: Patients with chronic myeloid leukemia from the state of Piauí were treated in only one reference center. Diagnosis was based on WHO 2008 criteria. Risk was assessed by Sokal, Hasford and EUTOS scores. Patients received 400 mg imatinib daily. We studied the influence of the following factors on the achievement of complete cytogenetic response within one year of treatment: age, clinical risk category, time interval between diagnosis and the start of imatinib treatment, geographic distance from the patient's home to the hospital, years of formal education and monthly income. RESULTS: Among 103 patients studied, the median age was 42 years; 65% of the patients had 2-9 years of formal education, and the median monthly income was approximately 100 US$. Imatinib was started in the first year after diagnosis (early chronic phase) in 69 patients. After 12 months of treatment, 68 patients had a complete cytogenetic response. The Hasford score, delay to start imatinib and years of formal education influenced the attainment of a complete cytogenetic response, whereas income and the distance from the home to the healthcare facility did not. CONCLUSION: Patients require additional healthcare information to better understand the importance of long-term oral anticancer treatment and to improve their compliance with the treatment. PMID:26039947

  6. Romance of the three domains: how cladistics transformed the classification of cellular organisms.


    Ho, Chi-Chun; Lau, Susanna K P; Woo, Patrick C Y


    Cladistics is a biological philosophy that uses genealogical relationship among species and an inferred sequence of divergence as the basis of classification. This review critically surveys the chronological development of biological classification from Aristotle through our postgenomic era with a central focus on cladistics. In 1957, Julian Huxley coined cladogenesis to denote splitting from subspeciation. In 1960, the English translation of Willi Hennig's 1950 work, Systematic Phylogenetics, was published, which received strong opposition from pheneticists, such as numerical taxonomists Peter Sneath and Robert Sokal, and evolutionary taxonomist, Ernst Mayr, and sparked acrimonious debates in 1960-1980. In 1977-1990, Carl Woese pioneered in using small subunit rRNA gene sequences to delimitate the three domains of cellular life and established major prokaryotic phyla. Cladistics has since dominated taxonomy. Despite being compatible with modern microbiological observations, i.e. organisms with unusual phenotypes, restricted expression of characteristics and occasionally being uncultivable, increasing recognition of pervasiveness and abundance of horizontal gene transfer has challenged relevance and validity of cladistics. The mosaic nature of eukaryotic and prokaryotic genomes was also gradually discovered. In the mid-2000s, high-throughput and whole-genome sequencing became routine and complex geneologies of organisms have led to the proposal of a reticulated web of life. While genomics only indirectly leads to understanding of functional adaptations to ecological niches, computational modeling of entire organisms is underway and the gap between genomics and phenetics may soon be bridged. Controversies are not expected to settle as taxonomic classifications shall remain subjective to serve the human scientist, not the classified.

  7. Dasatinib first-line: Multicentric Italian experience outside clinical trials.


    Breccia, Massimo; Stagno, Fabio; Luciano, Luigiana; Abruzzese, Elisabetta; Annunziata, Mario; D'Adda, Mariella; Maggi, Alessandro; Sgherza, Nicola; Russo-Rossi, Antonella; Pregno, Patrizia; Castagnetti, Fausto; Iurlo, Alessandra; Latagliata, Roberto; Cedrone, Michele; Di Renzo, Nicola; Sorà, Federica; Rege-Cambrin, Giovanna; La Nasa, Giorgio; Scortechini, Anna Rita; Greco, Giovanna; Franceschini, Luca; Sica, Simona; Bocchia, Monica; Crugnola, Monica; Orlandi, Esther; Guarini, Attilio; Specchia, Giorgina; Rosti, Gianantonio; Saglio, Giuseppe; Alimena, Giuliana


    Dasatinib was approved for the treatment of chronic phase (CP) chronic myeloid leukemia (CML) patients in first line therapy based on the demonstration of efficacy and safety reported in patients enrolled in clinical trials. We describe a multicentric Italian "real-life" experience of dasatinib used as frontline treatment outside clinical trials. One hundred and nine patients (median age 54 years) were treated from January 2012 to December 2013. Increased incidence of high risk patients were detected according to stratification (26% according to Sokal score, 19% according to Euro score and 16% according to EUTOS) when compared to company sponsored studies. Median time from diagnosis to start of dasatinib was 18 days. Ten patients received unscheduled starting dose (6 patients 50mg and 4 patients 80 mg QD), whereas 99 patients started with 100mg QD. At 3 months, 92% of patients achieved a BCR-ABL ratio less than 10%. At 6 months, the rate of CCyR was 91% and the rate of MR3 was 40%, with 8% of the patients reaching MR4.5. Ninety-three patients were evaluable at 12 months: the rate of MR3 was 62%, with MR4.5 being achieved by 19% of the patients. At a median follow-up of 12 months, 27 patients (24.7%) were receiving the drug at reduced dose. Two patients (1.8%) experienced a lymphoid blast crisis and the overall incidence of resistance was 8%. As regards safety, the major side effects recorded were thrombocytopenia, neutropenia and pleural effusions, which occurred in 22%, 10% and 8% of patients, respectively. Present results, achieved in a large cohort of patients treated outside clinical trials, further confirm the efficacy and safety of dasatinib as firstline treatment in CML.

  8. Testing the taxonomic integrity of Paranthropus boisei sensu stricto.


    Silverman, N; Richmond, B; Wood, B


    The craniodental hypodigm of Paranthropus boisei sensu stricto is morphologically distinctive, but it has been suggested that the substantial variation in mandibular and dental size in that hypodigm may exceed that which is reasonable to subsume within a single hominin species. In this study, Fligner and Killeen, coefficient of variation (CV)-based and average taxonomic distance (ATD)-based bootstrap tests, were used to compare variation in size and shape of the mandibular corpus remains attributed to P. boisei s.s. with the variation observed in samples of great apes and modern humans. The degree of size variation in the P. boisei s.s. mandibular hypodigm is never observed in human and chimpanzee samples, is rare in gorillas, but is not uncommon in orangutans. However, the shape variation in the fossil group is comparable to the variation in the extant reference groups. Although the size variation in P. boisei s.s. is substantial, it is exaggerated by the effects of taphonomy. The small mandibles are more often abraded, whereas the large mandibles are more likely to have been infiltrated with matrix. On the basis of the results of this investigation of the mandibular corpus, there are no grounds for rejecting the "single-species" hypothesis for P. boisei s.s. When Sokal and Braumann's adjusted CV values were used to predict the index of sexual dimorphism (ISD) for the P. boisei s.s., despite the substantial geological time embraced by the mandibular corpus hypodigm, the predicted value of lnISD, when corrected for taphonomic factors, is comparable to the sexual dimorphism observed within Gorilla.

  9. Early intervention during imatinib therapy in patients with newly diagnosed chronic-phase chronic myeloid leukemia: a study of the Spanish PETHEMA group

    PubMed Central

    Cervantes, Francisco; López-Garrido, Pilar; Montero, María-Isabel; Jonte, Fermín; Martínez, Jesús; Hernández-Boluda, Juan-Carlos; Calbacho, María; Sureda, Anna; Pérez-Rus, Gloria; Nieto, José B.; Pérez-López, Cristina; Román-Gómez, José; González, Marcos; Pereira, Arturo; Colomer, Dolors


    Background Despite the favorable results of imatinib front line in chronic-phase chronic myeloid leukemia there is room for improvement. Design and Methods Early intervention during imatinib therapy was undertaken in 210 adults with chronic-phase chronic myeloid leukemia less than three months from diagnosis (Sokal high risk: 16%). Patients received imatinib 400 mg/day. At three months, dose was increased if complete hematologic response was not achieved. At six months, patients in complete cytogenetic response were kept on 400 mg and the remainder randomized to higher imatinib dose or 400 mg plus interferon-alfa. At 18 months, randomized patients were switched to a 2nd generation tyrosine kinase inhibitor if not in complete cytogenetic response and imatinib dose increased in non-randomized patients not in major molecular response. Results Seventy-two percent of patients started imatinib within one month from diagnosis. Median follow-up is 50.5 (range: 1.2–78) months. At three months 4 patients did not have complete hematologic response; at six months 73.8% were in complete cytogenetic response; among the remainder, 9 could not be randomized (toxicity or consent withdrawal), 17 were assigned to high imatinib dose, and 15 to 400 mg + interferon-alpha. The low number of randomized patients precluded comparison between the two arms. Cumulative response at three years was: complete hematologic response 98.6%, complete cytogenetic response 90% and major molecular response 82%. On an intention-to-treat basis, complete cytogenetic response was 78.8% at 18 months. At five years, survival was 97.5%, survival free from accelerated/blastic phase 94.3%, failure free survival 82.5%, and event free survival (including permanent imatinib discontinuation) 71.5%. Conclusions These results indicate the benefit of early intervention during imatinib therapy ( Identifier: NCT00390897). PMID:20220063

  10. PREFACE: 2nd International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research''

    NASA Astrophysics Data System (ADS)

    Naumova, A. V.; Khodanovich, M. Y.; Yarnykh, V. L.


    The Second International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research'' was held on the campus of the National Research Tomsk State University (Tomsk, Russia) on September 7-9, 2015. The conference was focused on magnetic resonance imaging (MRI) applications for biomedical research. The main goal was to bring together basic scientists, clinical researchers and developers of new MRI techniques to bridge the gap between clinical/research needs and advanced technological solutions. The conference fostered research and development in basic and clinical MR science and its application to health care. It also had an educational purpose to promote understanding of cutting-edge MR developments. The conference provided an opportunity for researchers and clinicians to present their recent theoretical developments, practical applications, and to discuss unsolved problems. The program of the conference was divided into three main topics. First day of the conference was devoted to educational lectures on the fundamentals of MRI physics and image acquisition/reconstruction techniques, including recent developments in quantitative MRI. The second day was focused on developments and applications of new contrast agents. Multinuclear and spectroscopic acquisitions as well as functional MRI were presented during the third day of the conference. We would like to highlight the main developments presented at the conference and introduce the prominent speakers. The keynote speaker of the conference Dr. Vasily Yarnykh (University of Washington, Seattle, USA) presented a recently developed MRI method, macromolecular proton fraction (MPF) mapping, as a unique tool for modifying image contrast and a unique tool for quantification of the myelin content in neural tissues. Professor Yury Pirogov (Lomonosov Moscow State University) described development of new fluorocarbon compounds and applications for biomedicine. Drs. Julia Velikina and Alexey

  11. Non-Invasive Assessment of Susceptibility to Ventricular Arrhythmias During Simulated Microgravity

    NASA Technical Reports Server (NTRS)

    Cohen, Richard J.


    The Cardiovascular Alterations Team is currently conducting studies to determine what alterations in hemodynamic regulation result from sixteen days of simulated microgravity exposure in normal human subjects. In this project we make additional measurements on these same study subjects in order to determine whether there is an increase in susceptibility to ventricular arrhythmias resulting from simulated microgravity exposure. Numerous anecdotal and documented reports from the past 30 years suggest that the incidence of ventricular arrhythmias among astronauts is increased during space flight. For example, documented runs of ventricular tachycardia have been recorded from crew members of Skylab and Mir, there was much attention given by the lay press to Mir Commander Vasily Tslbliyev's complaints of heart rhythm irregularities in July of 1997, and cardiovascular mechanisms may have been causal in the recent death of an experimental primate shortly after return from space. In 1986, a Mir cosmonaut, Alexander Laveikin, was brought home and replaced with an alternate cosmonaut as a result of cardiac dysrhythmias that began during extravehicular activity. Furthermore, at a joint NASA/NSBRI workshop held in January 1998, cardiac arrhythmias were identified as the highest priority cardiovascular risk to a human Mars mission. Despite the evidence for the risk of a potentially lethal arrhythmia resulting from microgravity exposure, the effects of space flight and the associated physiologic stresses on cardiac conduction processes are not known, and an increase in cardiac susceptibility to arrhythmias has never been quantified. In this project, we are determining whether simulated space flight increases the risk of developing life-threatening heart rhythm disturbances such as sustained ventricular tachycardia (defined as ventricular tachycardia lasting at least 30 seconds or resulting in hemodynamic collapse) and ventricular fibrillation. We are obtaining measures of

  12. Age influences initial dose and compliance to imatinib in chronic myeloid leukemia elderly patients but concomitant comorbidities appear to influence overall and event-free survival.


    Breccia, Massimo; Luciano, Luigiana; Latagliata, Roberto; Castagnetti, Fausto; Ferrero, Dario; Cavazzini, Francesco; Trawinska, Malgorzata Monica; Annunziata, Mario; Stagno, Fabio; Tiribelli, Mario; Binotto, Gianni; Crisà, Elena; Musto, Pellegrino; Gozzini, Antonella; Cavalli, Laura; Montefusco, Enrico; Iurlo, Alessandra; Russo, Sabina; Cedrone, Michele; Rossi, Antonella Russo; Pregno, Patrizia; Endri, Mauro; Spadea, Antonio; Molica, Matteo; Giglio, Gianfranco; Celesti, Francesca; Sorà, Federica; Storti, Sergio; D'Addosio, Ada; Cambrin, Giovanna Rege; Isidori, Alessandro; Sica, Simona; Abruzzese, Elisabetta; Speccha, Giorgina; Rosti, Gianantonio; Alimena, Giuliana


    We applied Charlson comorbidity index (CCI) stratification on a large cohort of chronic myeloid leukemia (CML) very elderly patients (>75 years) treated with imatinib, in order to observe the impact of concomitant diseases on both compliance and outcome. One hundred and eighty-one patients were recruited by 21 Italian centers. There were 95 males and 86 females, median age 78.6 years (range 75-93.6). According to Sokal score, 106 patients were classified as intermediate risk and 55 as high risk (not available in 20 patients). According to CCI stratification, 71 patients had score 0 and 110 a score ≥ 1. Imatinib standard dose was reduced at start of therapy (200-300 mg/day) in 68 patients independently from the evaluation of baseline comorbidities, but based only on physician judgement: 43.6% of these patients had score 0 compared to 34% of patients who had score ≥ 1. Significant differences were found in terms of subsequent dose reduction (39% of patients with score 0 compared to 53% of patients with score ≥ 1) and in terms of drug discontinuation due to toxicity (35% of patients with score 0 vs 65% of patients with score ≥ 1). We did not find significant differences as regards occurrence of hematologic side effects, probably as a consequence of the initial dose reduction: 39% of patients with score 0 experienced grade 3/4 hematologic toxicity (most commonly anemia) compared to 42% of patients with score ≥ 1. Independently from the initial dose, comorbidities again did not have an impact on development of grade 3/4 non-hematologic side effects (most commonly skin rash, muscle cramps and fluid retention): 62% of patients with score 0 compared to 52.5% of patients with score ≥ 1. Notwithstanding the reduced dose and the weight of comorbidities we did not find significant differences but only a trend in terms of efficacy: 66% of patients with score 0 achieved a CCyR compared to 54% of patients with score ≥ 1. Comorbidities appeared to have an impact on

  13. Deep Ocean Tsunami Waves off the Sri Lankan Coast

    NASA Technical Reports Server (NTRS)


    fully understand the dynamics. Examination of other MISR images of this area, taken under similar illumination conditions, has not uncovered any surface patterns resembling those seen here. This image is an example of how MISR's multi-angular capability provides unique information for understanding how tsunamis propagate. Another application of MISR data enabled scientists to measure the motion of breaking tsunami waves along the eastern shores of Andhra Pradesh, India. The Multi-angle Imaging SpectroRadiometer observes the daylit Earth continuously and every 9 days views the entire globe between 82 degrees North and 82 degrees South latitude. These data products were generated from a portion of the imagery acquired during Terra orbit 26720 and utilize data from within blocks 85 to 86 within World Reference System-2 path 142. MISR was built and is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Office of Earth Science, Washington, DC. The Terra satellite is managed by NASA's Goddard Space Flight Center, Greenbelt, MD. Image courtesy NASA/GSFC/LaRC/JPL, MISR Team. Text by Clare Averill (Raytheon ITSS/JPL); Michael Garay and David J. Diner (JPL, California Institute of Technology); and Vasily Titov (NOAA/Pacific Marine Environmental Laboratory and University of Washington/Joint Institute for the Study of the Atmosphere and Oceans).

  14. A quantum Mermin-Wagner theorem for quantum rotators on two-dimensional graphs

    NASA Astrophysics Data System (ADS)

    Kelbert, Mark; Suhov, Yurii


    This is the first of a series of papers considering symmetry properties of quantum systems over 2D graphs or manifolds, with continuous spins, in the spirit of the Mermin-Wagner theorem [N. D. Mermin and H. Wagner, "Absence of ferromagnetism or antiferromagnetism in one- or two-dimensional isotropic Heisenberg models," Phys. Rev. Lett. 17, 1133-1136 (1966)], 10.1103/PhysRevLett.17.1133. In the model considered here (quantum rotators), the phase space of a single spin is a d-dimensional torus M, and spins (or particles) are attached to sites of a graph (Γ,E) satisfying a special bi-dimensionality property. The kinetic energy part of the Hamiltonian is minus a half of the Laplace operator -Δ/2 on M. We assume that the interaction potential is C2-smooth and invariant under the action of a connected Lie group G (i.e., a Euclidean space {{R}}^{d^' }} or a torus M' of dimension d' ⩽ d) on M preserving the flat Riemannian metric. A part of our approach is to give a definition (and a construction) of a class of infinite-volume Gibbs states for the systems under consideration (the class {G}). This class contains the so-called limit Gibbs states, with or without boundary conditions. We use ideas and techniques originated from papers [R. L. Dobrushin and S. B. Shlosman, "Absence of breakdown of continuous symmetry in two-dimensional models of statistical physics," Commun. Math. Phys. 42, 31-40 (1975), 10.1007/BF01609432; C.-E. Pfister, "On the symmetry of the Gibbs states in two-dimensional lattice systems," Commun. Math. Phys. 79, 181-188 (1981), 10.1007/BF01942060; J. Fröhlich and C. Pfister, "On the absence of spontaneous symmetry breaking and of crystalline ordering in two-dimensional systems," Commun. Math. Phys. 81, 277-298 (1981), 10.1007/BF01208901; B. Simon and A. Sokal, "Rigorous entropy-energy arguments," J. Stat. Phys. 25, 679-694 (1981), 10.1007/BF01022362; D. Ioffe, S. Shlosman and Y. Velenik, "2D models of statistical physics with continuous symmetry: The

  15. New method to determine initial surface water displacement at tsunami source

    NASA Astrophysics Data System (ADS)

    Lavrentyev, Mikhail; Romanenko, Alexey; Tatarintsev, Pavel


    earthquake. However, today it is not yet possible. Ground-based sea radars. This is an effective tool for direct measurement of tsunami wave. At the same time, the wave is measured at a rather narrow area in front of the radar and does not include information about neighboring parts of the wave. Direct measurement of tsunami wave at deep water [2]. Today, this technology is certainly among the most useful and promising. The DART II® system consists of a seafloor bottom pressure recording (BPR) system, capable of detecting tsunamis as small as 1 cm, and a moored surface buoy for real-time communications. We focus our research on improving the later method, direct measurement of tsunami wave at deep water. We suggest the new way to analyze DART data, modifying the methodology originally proposed by V. Titov. Smaller system of unit sources [3] should be considered to approximate all typical shapes of initial disturbance by several suitable basis functions. To successfully implement it, performance of data analysis should be dramatically improved. This could be done by using a signal orthogonalization procedure for considered system of unit sources and calculation of Fourier coefficients of the measured time series with respect to orthogonal basis. The approach suggested was used as a part of computerized workstation for tsunami hazard monitoring [5-6]. National Oceanic and Atmospheric Administration Center for Tsunami Research. URL: National Data Buoy Center. URL: National Oceanic and Atmospheric Administration Center for Tsunami Research. URL: National Oceanic and Atmospheric Administration Center for Tsunami Research. URL: Alexey Romanenko, Mikhail Lavrentiev-jr, Vasily Titov, "Modern Architecture for Tsunami Hazard Mitigation" // Asia Oceania Geosciences Society (AOGS-2012), ISBN 978-981-07-2049-0 Mikhail

  16. PREFACE: Rusnanotech 2010 International Forum on Nanotechnology

    NASA Astrophysics Data System (ADS)

    Kazaryan, Konstantin


    Deputy Director, Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, RussiaProf Vladimir Kvardakov, Corresponding Member of Russian Academy of SciencesExecutive Director, Kurchatov Center of Synchrotron Radiation and Nanotechnology, RussiaProf Edward Son, Corresponding member of Russian Academy of SciencesScientific Deputy Director, Joint Institute for High Temperatures, Russian Academy of Sciences, RussiaProf Andrey GudkovSenior Vice President, Basic Science Chairman, Department of Cell Stress Biology, Roswell Park Cancer Institute, USAProf Robert NemanichChair, Department of Physics, Arizona State University, USAProf Kandlikar SatishProfessor, Rochester Institute of Technology, USAProf Xiang ZhangUC Berkeley, Director of NSF Nano-scale Science and Engineering Center (NSEC), USAProf Andrei ZvyaginProfessor, Macquarie University, AustraliaProf Sergey KalyuzhnyDirector of the Scientific and Technological Expertise Department, RUSNANO, RussiaKonstantin Kazaryan, PhDExpert of the Scientific and Technological Expertise Department, RUSNANO, Russia, Program Committee SecretarySimeon ZhavoronkovHead of Nanotechnology Programs Development Office, Rusnanotech Forum Fund for the Nanotechnology Development, Russia Editors of the proceedings: Section "Nanoelectronics" - Corresponding Member of Russian Academy of Sciences, Professor Anatoly Dvurechenskii (Institute of Semiconductor Physics, RAS).Section "Nanophotonics" - Professor Vasily Klimov (Institute of Physics, RAS).Section "Nanodiagnostics" - Professor P Kashkarov (Russian Scientific Center, Kurchatov Institute).Section "Nanotechnology for power engineering" - Corresponding Member of Russian Academy of Sciences, Professor Eduard Son (Joint Institute for High Temperatures, RAS).Section "Catalysis and chemical industry" - Member of Russian Academy of Sciences, Professor Valentin Parmon (Institute of Catalysis SB RAS).Section "Nanomaterials" - E Obraztsova, PhD (Institute of Physics, RAS), Marat Gallamov Ph

  17. Interglacial-glacial cycles recorded in the deposit sequence at Kruzhyky on the Dniester River (East Carpathian Foreland)

    NASA Astrophysics Data System (ADS)

    Łanczont, Maria; Boguckyj, Aandrij; Mroczek, Przemysław; Zieliński, Paweł; Jacyszyn, Andrij; Pidek, Agnieszka I.; Urban, Danuta; Kulesza, Piotr; Hołub, Beata


    of sands with horizontal stratification and silts with horizontal or flaser lamination; single small-scale lithofacies of sands with trough cross-stratification occur in places; single gravel grains are numerous. Two deformation horizons are found: the higher one is characterized by the occurrence of folds and flexure deflections, and the lower one-involution structures and casts of ice wedges/fissures. This complex is probably the result of deposition on the distal part of flat, periodically inundated fluvioglacial fan connected with advancing ice sheet. 4. Ablation complex-sandy or sandy-silty diamicton occurring as isolated inserts, lenses or tongues. Its lower boundary is sharp, erosional and uneven (concave). This complex represents flows of supraglacial tills, which strongly deformed the deposits of the underlying complex 3. 5. Aeolian complex-silty (loess) and sandy-silty (Table 1) deposits with distinct traces of intensive, postsedimentary alterations of pedogenesis of different ages (Tables 1 and 2). It is composed of two soil units separated by thin, primary loess layer: a) older, well-developed paleosol with several pedofeatures very typical of the Sokal (Mazovian) soil; b) younger unit developed as pedocomplex consisting of two mature soils, the upper of which ("modern" neosol) is formed in the top of relict and exhumed paleosol. The described paleosols should be recognized as at least two soils of different ages and of interglacial rank, developed in periglacial loess-like deposits. The Kruzhyky profile is unique in the Dniester River valley. On account of its situation, it supplements the former information about the terrace 5 structure, which has been determined in detail in the Halyč site. And what is most important, it is the only site on the terrace 5 where glacial deposits were found. Lithofacial analysis carried out in the profile enables us to reconstruct the following events reflecting interglacial-glacial cycles: 1. The lowest, gravelly

  18. EDITORIAL: Focus on Cloaking and Transformation Optics

    NASA Astrophysics Data System (ADS)

    Leonhardt, Ulf; Smith, David R.


    coordinate transformations. If the coordinates they conjure up run backwards one gets negative refraction, if they exclude some region of space one makes anything inside invisible [4]. In physics, general relativity has honed the theoretical tools for understanding curved space and curved-coordinate transformations. In transformation optics, general relativity has become a theoretical tool for solving practical engineering problems [4]. What an unorthodox connection! This focus issue represents a snapshot of this rapidly developing research area. It is not restricted to optics or electromagnetism, though. Metamaterials for acoustics also exist and can be applied in ways similar to optical metamaterials. So transformation optics not only attracts an unusual mix of scientists, but also spans a range of applications in optics and beyond. Transformation optics has the potential to transform optics, for example by visualizing invisibility and making materials beyond materials—metamaterials. But before we transgress the boundaries to the hermeneutics of transformation optics [5], let the papers speak for themselves. References [1] Yao J, Liu Z, Liu Y, Wang Y, Sun C, Bartal G, Stacy A M and Zhang X 2008 Science 321 930 [2] Valentine J, Zhang S, Zentgraf T, Ulin-Avila E, Genov D A, Bartal G and Zhang X 2008 Nature 455 376 [3] Schurig D, Mock J J, Justice B J, Cummer S A, Pendry J B, Starr A F and Smith D R 2006 Science 314 977 [4] Leonhardt U and Philbin T G 2006 New J. Phys. 8 247 [5] Sokal A D 1996 Social Text 14(46/47) 217 Focus on Cloaking and Transformation Optics Contents Transformation optics for the full dielectric electromagnetic cloak and metal-dielectric planar hyperlens D P Gaillot, C Croënne, F Zhang and D Lippens Transmutation of singularities in optical instruments Tomáš Tyc and Ulf Leonhardt Electromagnetic cloaking with canonical spiral inclusions K Guven, E Saenz, R Gonzalo, E Ozbay and S Tretyakov Theory and potentials of multi-layered plasmonic covers for

  19. List of Participants

    NASA Astrophysics Data System (ADS)


    Physique Théorique, École Polytechnique, Palaiseau Diego Mansi Università Degli Studi di Milano Matteo Marescotti Università del Piemonte Orientale, Alessandria Alberto Mariotti Università di Milano-Bicocca Raffaele Marotta Istituto Nazionale di Fisica Nucleare, Napoli Alessio Marrani Istituto Nazionale di Fisica Nucleare and LNF, Firenze Luca Martucci Instituto de Física Teórica, Madrid and Katholieke Universiteit Leuven David Mateos University of California, Santa Barbara Andrea Mauri Università di Milano Liuba Mazzanti Università di Milano-Bicocca Patrick Meessen Instituto de Física Teórica, Universidad Autónoma de Madrid Lotta Mether Helsinki Institute of Physics Rene Meyer Max-Planck-Institut für Physik, München Giuseppe Milanesi SISSA, Trieste Cesar Miquel-Espanya Universitat de Valencia and Instituto de Física Corpuscular, Valencia Alexander Monin Institute for Theoretical and Experimental Physics (ITEP), Moscow and Moscow State University (MSU) Samuel Monnier Université de Genève Sergio Montero Instituto de Física Teórica, Madrid Nicola Mori Università di Firenze Alexander Marcel Morisse University of California, Santa Cruz Sebastian Moster Max-Planck-Institut für Physik, München Adele Nasti Queen Mary, University of London Vasilis Niarchos École Polytechnique, Palaiseau Emil Nissimov Institute for Nuclear Research and Nuclear Energy, Sofia Francesco Nitti École Polytechnique, Palaiseau Eoin O'Colgain Imperial College, London Niels Obers Niels Bohr Institute, København Rodrigo Olea Università Degli Studi di Milano Marta Orselli Niels Bohr Institute, København Enrico PajerLudwig-Maximilians-Universität, München Eran PaltiOxford University Georgios PapathanasiouBrown University, Providence, RI Angel ParedesCentre de Physique Théorique, École Polytechnique, Palaiseau Jeong-Hyuck ParkMax-Planck-Institut für Physik, München Sara PasquettiUniversità di Parma Silvia PenatiUniversità di Milano-Bicocca Igor PesandoUniversità di Torino