One year of migration data for a western yellow-billed cuckoo

USGS Publications Warehouse

Sechrist, Juddson D.; Paxton, Eben H.; Ahlers, Darrell D.; Doster, Robert H.; Ryan, Vicky M.

2012-01-01

In 2009, we studied the migration of the Western Yellow-billed Cuckoo by capturing 13 breeding birds on the middle Rio Grande, New Mexico, and attaching a 1.5-g Mk 14-S British Antarctic Survey geolocator to each bird. In 2010, we recaptured one of the cuckoos, enabling us to download its geolocation data. The cuckoo had flown approximately 9500 km during its southward migration, traveling through Central America to winter in portions of Bolivia, Brazil, Paraguay, and Argentina. The spring migration route differed somewhat from the fall route, with the cuckoo bypassing Central America to migrate through the Caribbean. Additionally, it moved between New Mexico and Mexico at the end of summer in 2009 and again in 2010 before being recaptured at its breeding site. Our results, albeit from one individual, hint at a dynamic migration strategy and have broad implications for the ecology and conservation of the Western Yellow-billed Cuckoo, a species of conservation concern.

The Effects of Cognitive Styles on the Use of Hints in Academic English: A Learning Analytics Approach

ERIC Educational Resources Information Center

Chen, Sherry Y.; Yeh, Chia-Chi

2017-01-01

Various hints have been proposed to scaffold students. Such hints can be broadly divided into direct hints and indirect hints. On the other hand, individual differences existed among learners. In particular, cognitive styles greatly affect student learning. However, there is a lack of studies to investigate how cognitive styles affect students'…

Codec-on-Demand Based on User-Level Virtualization

NASA Astrophysics Data System (ADS)

Zhang, Youhui; Zheng, Weimin

At work, at home, and in some public places, a desktop PC is usually available nowadays. Therefore, it is important for users to be able to play various videos on different PCs smoothly, but the diversity of codec types complicates the situation. Although some mainstream media players can try to download the needed codec automatically, this may fail for average users because installing the codec usually requires administrator privileges to complete, while the user may not be the owner of the PC. We believe an ideal solution should work without users' intervention, and need no special privileges. This paper proposes such a user-friendly, program-transparent solution for Windows-based media players. It runs the media player in a user-mode virtualization environment, and then downloads the needed codec on-the-fly. Because of API (Application Programming Interface) interception, some resource-accessing API calls from the player will be redirected to the downloaded codec resources. Then from the viewpoint of the player, the necessary codec exists locally and it can handle the video smoothly, although neither system registry nor system folders was modified during this process. Besides convenience, the principle of least privilege is maintained and the host system is left clean. This paper completely analyzes the technical issues and presents such a prototype which can work with DirectShow-compatible players. Performance tests show that the overhead is negligible. Moreover, our solution conforms to the Software-As-A-Service (SaaS) mode, which is very promising in the Internet era.

An Open Task to Promote Students to Create Statistical Concepts through Modelling

ERIC Educational Resources Information Center

Albarracín, Lluís; Aymerich, Àngels; Gorgorió, Núria

2017-01-01

This article reports on the solutions of a group of 22 students, aged 15/16 years old, when facing a statistical modelling activity. They were given the salary lists of 5 companies and were asked what could be said about their salary structure; no hint was given. The results show that students not only used a wide range of data concepts and…

Increased anxiety-related behaviour in Hint1 knockout mice.

PubMed

Varadarajulu, Jeeva; Lebar, Maria; Krishnamoorthy, Gurumoorthy; Habelt, Sonja; Lu, Jia; Bernard Weinstein, I; Li, Haiyang; Holsboer, Florian; Turck, Christoph W; Touma, Chadi

2011-07-07

Several reports have implicated a role for the histidine triad nucleotide-binding protein-1 (Hint1) in psychiatric disorders. We have studied the emotional behaviour of male Hint1 knockout (Hint1 KO) mice in a battery of tests and performed biochemical analyses on brain tissue. The behavioural analysis revealed that Hint1 KO mice exhibit an increased emotionality phenotype compared to wildtype (WT) mice, while no significant differences in locomotion or general exploratory activity were noted. In the elevated plus-maze (EPM) test, the Hint1 KO animals entered the open arms of the apparatus less often than WT littermates. Similarly, in the dark-light box test, Hint1 KO mice spent less time in the lit compartment and the number of entries were reduced, which further confirmed an increased anxiety-related behaviour. Moreover, the Hint1 KO animals showed significantly more struggling and less floating behaviour in the forced swim test (FST), indicating an increased emotional arousal in aversive situations. Hint1 is known as a protein kinase C (PKC) interacting protein. Western blot analysis showed that PKCγ expression was elevated in Hint1 KO compared to WT mice. Interestingly, PKCγ mRNA levels of the two groups did not show a significant difference, implying a post-transcriptional PKCγ regulation. In addition, PKC enzymatic activity was increased in Hint1 KO compared to WT mice. In summary, our results indicate a role for Hint1 and PKCγ in modulating anxiety-related and stress-coping behaviour in mice. Copyright © 2011 Elsevier B.V. All rights reserved.

Hint2, the mitochondrial nucleoside 5'-phosphoramidate hydrolase; properties of the homogeneous protein from sheep (Ovis aries) liver.

PubMed

Bretes, Ewa; Wojdyła-Mamoń, Anna M; Kowalska, Joanna; Jemielity, Jacek; Kaczmarek, Renata; Baraniak, Janina; Guranowski, Andrzej

2013-01-01

Adenosine 5'-phosphoramidate (NH2-pA) is a rare natural nucleotide and its biochemistry and biological functions are poorly recognized. All organisms have proteins that may be involved in the catabolism of NH2-pA. They are members of the HIT protein family and catalyze hydrolytic splitting of NH2-pA to 5'-AMP and ammonia. At least five HIT proteins have been identified in mammals; however, the enzymatic and molecular properties of only Fhit and Hint1 have been comprehensively studied. Our study focuses on the Hint2 protein purified by a simple procedure to homogeneity from sheep liver mitochondrial fraction (OaHint2). Hint1 protein was also prepared from sheep liver (OaHint1) and the molecular and kinetic properties of the two proteins compared. Both function as homodimers and behave as nucleoside 5'-phosphoramidate hydrolases. The molecular mass of the OaHint2 monomer is 16 kDa and that of the OaHint1 monomer 14.9 kDa. Among potential substrates studied, NH2-pA appeared to be the best; the Km and kcat values estimated for this compound are 6.6 μM and 68.3 s⁻¹, and 1.5 μM and 11.0 s⁻¹ per natively functioning dimer of OaHint2 and OaHint1, respectively. Studies of the rates of hydrolysis of different NH2-pA derivatives show that Hint2 is more specific towards compounds with a P-N bond than Hint1. The thermostability of these two proteins is also compared.

The National Map: New Viewer, Services, and Data Download

USGS Publications Warehouse

Dollison, Robert M.

2010-01-01

Managed by the U.S. Geological Survey's (USGS) National Geospatial Program, The National Map has transitioned data assets and viewer applications to a new visualization and product and service delivery environment, which includes an improved viewing platform, base map data and overlay services, and an integrated data download service. This new viewing solution expands upon the National Geospatial Intelligence Agency (NGA) Palanterra X3 viewer, providing a solid technology foundation for navigation and basic Web mapping functionality. Building upon the NGA viewer allows The National Map to focus on improving data services, functions, and data download capabilities. Initially released to the public at the 125th anniversary of mapping in the USGS on December 3, 2009, the viewer and services are now the primary distribution point for The National Map data. The National Map Viewer: http://viewer.nationalmap.gov

Multiple Chirality in Nuclear Rotation: A Microscopic View

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, P. W.

Covariant density functional theory and three-dimensional tilted axis cranking are used to investigate multiple chirality in nuclear rotation for the first time in a fully self-consistent and microscopic way. Two distinct sets of chiral solutions with negative and positive parities, respectively, are found in the nucleus 106Rh. The negative-parity solutions reproduce well the corresponding experimental spectrum as well as the B(M1)/B(E2) ratios of the transition strengths. Finally, this indicates that a predicted positive-parity chiral band should also exist. Therefore, it provides a further strong hint that multiple chirality is realized in nuclei.

Multiple Chirality in Nuclear Rotation: A Microscopic View

DOE PAGES

Zhao, P. W.

2017-10-10

Covariant density functional theory and three-dimensional tilted axis cranking are used to investigate multiple chirality in nuclear rotation for the first time in a fully self-consistent and microscopic way. Two distinct sets of chiral solutions with negative and positive parities, respectively, are found in the nucleus 106Rh. The negative-parity solutions reproduce well the corresponding experimental spectrum as well as the B(M1)/B(E2) ratios of the transition strengths. Finally, this indicates that a predicted positive-parity chiral band should also exist. Therefore, it provides a further strong hint that multiple chirality is realized in nuclei.

A Secure Content Delivery System Based on a Partially Reconfigurable FPGA

NASA Astrophysics Data System (ADS)

Hori, Yohei; Yokoyama, Hiroyuki; Sakane, Hirofumi; Toda, Kenji

We developed a content delivery system using a partially reconfigurable FPGA to securely distribute digital content on the Internet. With partial reconfigurability of a Xilinx Virtex-II Pro FPGA, the system provides an innovative single-chip solution for protecting digital content. In the system, a partial circuit must be downloaded from a server to the client terminal to play content. Content will be played only when the downloaded circuit is correctly combined (=interlocked) with the circuit built in the terminal. Since each circuit has a unique I/O configuration, the downloaded circuit interlocks with the corresponding built-in circuit designed for a particular terminal. Thus, the interface of the circuit itself provides a novel authentication mechanism. This paper describes the detailed architecture of the system and clarify the feasibility and effectiveness of the system. In addition, we discuss a fail-safe mechanism and future work necessary for the practical application of the system.

Theory-Driven Hints in the Cheap Necklace Problem: A Preliminary Investigation

ERIC Educational Resources Information Center

Chu, Yun; Dewald, Andrew D.; Chronicle, Edward P.

2007-01-01

Three experiments investigated the effects of two hints derived from the Criterion for Satisfactory Progress theory (CSP) and Representational Change Theory (RCT) on the cheap necklace problem (insight problem). In Experiment 1, fewer participants given the CSP hint used an incorrect (maximizing) first move than participants given the RCT hint or…

A communication efficient and scalable distributed data mining for the astronomical data

NASA Astrophysics Data System (ADS)

Govada, A.; Sahay, S. K.

2016-07-01

In 2020, ∼60PB of archived data will be accessible to the astronomers. But to analyze such a paramount data will be a challenging task. This is basically due to the computational model used to download the data from complex geographically distributed archives to a central site and then analyzing it in the local systems. Because the data has to be downloaded to the central site, the network BW limitation will be a hindrance for the scientific discoveries. Also analyzing this PB-scale on local machines in a centralized manner is challenging. In this, virtual observatory is a step towards this problem, however, it does not provide the data mining model (Zhang et al., 2004). Adding the distributed data mining layer to the VO can be the solution in which the knowledge can be downloaded by the astronomers instead the raw data and thereafter astronomers can either reconstruct the data back from the downloaded knowledge or use the knowledge directly for further analysis. Therefore, in this paper, we present Distributed Load Balancing Principal Component Analysis for optimally distributing the computation among the available nodes to minimize the transmission cost and downloading cost for the end user. The experimental analysis is done with Fundamental Plane (FP) data, Gadotti data and complex Mfeat data. In terms of transmission cost, our approach performs better than Qi et al. and Yue et al. The analysis shows that with the complex Mfeat data ∼90% downloading cost can be reduced for the end user with the negligible loss in accuracy.

Using Collaborative Web Technology to Construct the Health Information National Trends Survey (HINTS)

PubMed Central

MOSER, RICHARD P.; BECKJORD, ELLEN BURKE; RUTTEN, LILA J. FINNEY; BLAKE, KELLY; HESSE, BRADFORD W.

2012-01-01

Scientists are taking advantage of web-based technology to work in new collaborative environments, a phenomenon known as Science 2.0. The National Cancer Institute (NCI) created a web-based tool called HINTS-GEM that allows a diverse group of stakeholders to collaborate in a virtual environment by providing input on content for the Health Information National Trends Survey (HINTS). This involved stakeholders providing new suggested content and commenting and rating on existing content. HINTS is a nationally-representative survey of the US non-institutionalized adult population (see Finney Rutten et al. [this journal] for more information about the HINTS program). This paper describes the conceptual development of HINTS-GEM and provides results of its use by stakeholders in creating an improved survey instrument. PMID:23020764

Copernicus Space Component: Status and Evolution

NASA Astrophysics Data System (ADS)

Jutz, Simon; Milagro Perez, Maria Pilar

2017-04-01

The Copernicus environment-monitoring programme with its fleet of Sentinel satellites forming the heart of the programme's space component, entered its operational phase in 2014 with the launch of the first dedicated satellite, Sentinel-1 A. In the meantime three more spacecraft have been launched in 2015 and 2016 and other three will be launched this year. To complete the caravan of Sentinel satellites, eight more spacecraft and 5 additional Sentinel instruments, embarked on European meteorological satellites, will be put in orbit and will cover all environmental domains. The data are distributed free of charge as part of a European policy seeking to stimulate downstream value-added Earth observation-related business. With this space configuration, an uninterrupted data delivery to users is guaranteed until at least 2030. Over 54000 users world-wide are accessing Sentinel data from several data access hubs developed by ESA. Over 13 PB of data have been already downloaded with an average of several TB of data products downloaded every day, making Copernicus a Big Data challenge. These figures will grow as new satellites will be put in orbit. In the meantime, and thinking of a near term future, new priorities have been introduced in the EU policies and new societal needs and challenges have arisen requiring new observations. This will lead to what has been called the Sentinels' expansion. The expansion of the Sentinel family is a joint EU-ESA endeavour which just started concerning the investigation of new domains/techniques for future satellite missions like a greenhouse gases emissions mission, polar ice/ocean interferometric altimetry, thermal Infrared, soil moisture or hyper-spectral land imaging. This presentation will therefore give an overview of the current status of the space component and corresponding data access, and some hints on the future perspectives of the Copernicus space component.

Time to Completion of Web-Based Physics Problems with Tutoring

PubMed Central

Warnakulasooriya, Rasil; Palazzo, David J; Pritchard, David E

2007-01-01

We studied students performing a complex learning task, that of solving multipart physics problems with interactive tutoring on the web. We extracted the rate of completion and fraction completed as a function of time on task by retrospectively analyzing the log of student–tutor interactions. There was a spontaneous division of students into three groups, the central (and largest) group (about 65% of the students) being those who solved the problem in real time after multiple interactions with the tutorial program (primarily receiving feedback to submitted wrong answers and requesting hints). This group displayed a sigmoidal fraction-completed curve as a function of logarithmic time. The sigmoidal shape is qualitatively flatter for problems that do not include hints and wrong-answer responses. We argue that the group of students who respond quickly (about 10% of the students) is obtaining the answer from some outside source. The third group (about 25% of the students) represents those who interrupt their solution, presumably to work offline or to obtain outside help. PMID:17725054

A web-based solution for 3D medical image visualization

NASA Astrophysics Data System (ADS)

Hou, Xiaoshuai; Sun, Jianyong; Zhang, Jianguo

2015-03-01

In this presentation, we present a web-based 3D medical image visualization solution which enables interactive large medical image data processing and visualization over the web platform. To improve the efficiency of our solution, we adopt GPU accelerated techniques to process images on the server side while rapidly transferring images to the HTML5 supported web browser on the client side. Compared to traditional local visualization solution, our solution doesn't require the users to install extra software or download the whole volume dataset from PACS server. By designing this web-based solution, it is feasible for users to access the 3D medical image visualization service wherever the internet is available.

Adults Living with OI

MedlinePlus

... Click the logo below to download this free software. Go to the Resources Page to view all our online resources Miscellaneous: Web Communities Connect to others affected by OI through to the chat room or an instant messaging service, or leave your thoughts, ideas or solutions on ...

Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression.

PubMed

Bao, Tianhao; Ke, Yang; Wang, Yifan; Wang, Weiwei; Li, Yuehua; Wang, Yan; Kui, Xiang; Zhou, Qixin; Zhou, Han; Zhang, Cheng; Zhou, Dongming; Wang, Lin; Xiao, Chunjie

2018-07-01

Taraxasterol has potent anti-inflammatory and anti-tumor activity. However, the effect and potential mechanisms of Taraxasterol on the growth of human liver cancer have not been clarified. Histidine triad nucleotide-binding protein 1 (Hint1) is a tumor suppressor and its downregulated expression is associated with the development of cancer. Here, we report that Taraxasterol treatment significantly suppressed cell proliferation and induced cell cycle arrest at G0/G1 phase and apoptosis in liver cancer cells, but not in non-tumor hepatocytes. Furthermore, Taraxasterol upregulated Hint1 and Bax, but downregulated Bcl2 and cyclin D1 expression, accompanied by promoting the demethylation in the Hint1 promoter region in liver cancer cells. The effects of Taraxasterol were abrogated by Hint1 silencing and partially mitigated by Bax silencing, Bcl2 or cyclin D1 over-expression in HepG2 cells. Moreover, oral administration with Taraxasterol did not affect body weight, urinary protein levels, and the heart, liver, and kidney morphology in BALB/c mice but effectively inhibited the growth of implanted SK-Hep1 tumor in vivo. Collectively, we demonstrate that Taraxasterol inhibits the growth of liver cancer at least partially by enhancing Hint1 expression to regulate Bax, Bcl2, and cyclin D1 expression. Taraxasterol may be a drug candidate for the treatment of human liver cancer. Taraxasterol inhibits growth and induces apoptosis in human liver cancer cells. Taraxasterol enhances Hint1 expression by promoting demethylation in Hint1 promoter. Taraxasterol increases Hint1 levels to regulate Bax, Bcl2, and cyclinD1 expression. The effects of Taraxasterol are abrogated by Hint1 silencing in liver cancer cells. Taraxasterol inhibits the growth of subcutaneously implanted liver cancers in mice.

Cables and connectors: A compilation

NASA Technical Reports Server (NTRS)

1974-01-01

A compilation is presented that reflects the uses, adaptation, and maintenance plus service, that are innovations derived from problem solutions in the space R and D programs, both in house and by NASA and AEC contractors. Data cover: (1) technology revelant to the employment of flat conductor cables and their adaptation to and within conventional systems, (2) connectors and various adaptations, and (3) maintenance and service technology, and shop hints useful in the installation and care of cables and connectors.

Polyelectrolyte bundles

NASA Astrophysics Data System (ADS)

Limbach, H. J.; Sayar, M.; Holm, C.

2004-06-01

Using extensive Molecular Dynamics simulations we study the behavior of polyelectrolytes with hydrophobic side chains, which are known to form cylindrical micelles in aqueous solution. We investigate the stability of such bundles with respect to hydrophobicity, the strength of the electrostatic interaction, and the bundle size. We show that for the parameter range relevant for sulfonated poly-para-phenylenes (PPP) one finds a stable finite bundle size. In a more generic model we also show the influence of the length of the precursor oligomer on the stability of the bundles. We also point out that our model has close similarities to DNA solutions with added condensing agents, hinting to the possibility that the size of DNA aggregates is under certain circumstances thermodynamically limited.

Comparing the performance plateau in adult cochlear implant patients using HINT and AzBio.

PubMed

Massa, Sean T; Ruckenstein, Michael J

2014-04-01

This study aims to characterize the performance plateau in adult cochlear implant recipients after the initial postimplantation increase by using word recognition testing and an explicit definition of performance plateau. Retrospective review. Urban, tertiary referral center. One hundred twenty-five patients with 138 devices tested with AzBio were matched to 130 patients with 138 devices tested with HINT based on performed on CNC monosyllable tests. Patient's performance was measured overtime using AzBio and HINT tests to determine when and at what score their performance reached a plateau. Time from implantation to reach a performance plateau and plateau score with each test. Thirty-four devices reached a HINT plateau and 30 devices reached an AzBio plateau. Patients reached plateaus at similar times postoperatively using HINT and AzBio, 18.8 and 16.5 weeks, respectively (p = 0.476). Five patients tested with HINT plateaued at scores of 99% to 100%, whereas no patients plateaued above 92% with AzBio. Patients reached a plateau in performance at similar median times using AzBio and HINT, despite the ceiling effect of HINT in some patients. Most patients who reach a plateau did so within 4 months, but exactly when and if a patient's performance plateaus varies significantly among individuals. Further study is required to determine which test best reflects when a patient reaches his or her maximal performance in natural listening conditions.

Methodology for the Model-based Small Area Estimates of Cancer-Related Knowledge - Small Area Estimates

Cancer.gov

The HINTS is designed to produce reliable estimates at the national and regional levels. GIS maps using HINTS data have been used to provide a visual representation of possible geographic relationships in HINTS cancer-related variables.

P-Hint-Hunt: a deep parallelized whole genome DNA methylation detection tool.

PubMed

Peng, Shaoliang; Yang, Shunyun; Gao, Ming; Liao, Xiangke; Liu, Jie; Yang, Canqun; Wu, Chengkun; Yu, Wenqiang

2017-03-14

The increasing studies have been conducted using whole genome DNA methylation detection as one of the most important part of epigenetics research to find the significant relationships among DNA methylation and several typical diseases, such as cancers and diabetes. In many of those studies, mapping the bisulfite treated sequence to the whole genome has been the main method to study DNA cytosine methylation. However, today's relative tools almost suffer from inaccuracies and time-consuming problems. In our study, we designed a new DNA methylation prediction tool ("Hint-Hunt") to solve the problem. By having an optimal complex alignment computation and Smith-Waterman matrix dynamic programming, Hint-Hunt could analyze and predict the DNA methylation status. But when Hint-Hunt tried to predict DNA methylation status with large-scale dataset, there are still slow speed and low temporal-spatial efficiency problems. In order to solve the problems of Smith-Waterman dynamic programming and low temporal-spatial efficiency, we further design a deep parallelized whole genome DNA methylation detection tool ("P-Hint-Hunt") on Tianhe-2 (TH-2) supercomputer. To the best of our knowledge, P-Hint-Hunt is the first parallel DNA methylation detection tool with a high speed-up to process large-scale dataset, and could run both on CPU and Intel Xeon Phi coprocessors. Moreover, we deploy and evaluate Hint-Hunt and P-Hint-Hunt on TH-2 supercomputer in different scales. The experimental results illuminate our tools eliminate the deviation caused by bisulfite treatment in mapping procedure and the multi-level parallel program yields a 48 times speed-up with 64 threads. P-Hint-Hunt gain a deep acceleration on CPU and Intel Xeon Phi heterogeneous platform, which gives full play of the advantages of multi-cores (CPU) and many-cores (Phi).

No Strings Attached: Open Source Solutions

ERIC Educational Resources Information Center

Fredricks, Kathy

2009-01-01

Imagine downloading a new software application and not having to worry about licensing, finding dollars in the budget, or incurring additional maintenance costs. Imagine finding a Web design tool in the public domain--free for use. Imagine major universities that provide online courses with no strings attached. Imagine online textbooks without a…

HINTS 2013 Conference Summaries of Presentations and Posters

Cancer.gov

Summaries of Presentations and Poster Abstracts for the HINTS 2013 Conference titled A Decade of HINTS: Quantifying the Health Information Revolution through Data Innovation and Collaboration and held on October 2-3, 2013 at the Natcher building on the NIH campus in Bethesda, MD

Lack of Neuropathy-Related Phenotypes in Hint1 Knockout Mice

PubMed Central

Seburn, Kevin L.; Morelli, Kathryn H.; Jordanova, Albena; Burgess, Robert W.

2014-01-01

Mutations in HINT1, the gene encoding histidine triad nucleotide-binding protein 1 (HINT1), cause a recessively inherited peripheral neuropathy that involves primarily motor dysfunction and is usually associated with neuromyotonia, i.e. prolonged muscle contraction resulting from hyperexcitability of the peripheral nerve. Because these mutations are hypothesized to cause loss of function, we analyzed Hint1 knockout mice for their relevance as a disease model. Mice lacking Hint1 were normal in appearance and in behavioral tests or motor performance, although they moved slower and for a smaller fraction of time than wild-type (WT) mice in an open field arena. Muscles, neuromuscular junctions, and nodes of Ranvier are anatomically normal and did not show evidence of degeneration or regeneration. Axon numbers and myelination in peripheral nerves were normal at 4 and 13 months of age. Axons were slightly smaller than those in WT mice at 4 months of age, but this did not cause a decrease in conduction velocity, and no differences in axon diameters were detected at 13 months. Using electromyography, we were unable to detect neuromyotonia, even using supra-physiological stimuli and stressors such as reduced temperature or 3,4 diaminopyridine to block potassium channels. Therefore, we conclude that Hint1 knockout mice may be useful for studying the biochemical activities of HINT1, but these mice do not provide a disease model or a means for investigating the basis of HINT1-associated neuropathy and neuromyotonia. PMID:24918641

Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.

PubMed

Dolot, Rafał; Kaczmarek, Renata; Sęda, Aleksandra; Krakowiak, Agnieszka; Baraniak, Janina; Nawrot, Barbara

2016-06-01

Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine triad proteins superfamily. HINT1 plays an important role in various biological processes, and it has been found in many species. Here, we report the first structure (at a 2.34Å resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal. In addition, the apo form of hHINT1 at the space group P21 refined to 1.92Å is reported for comparative studies. Copyright © 2016 Elsevier B.V. All rights reserved.

Tools for building a comprehensive modeling system for virtual screening under real biological conditions: The Computational Titration algorithm.

PubMed

Kellogg, Glen E; Fornabaio, Micaela; Chen, Deliang L; Abraham, Donald J; Spyrakis, Francesca; Cozzini, Pietro; Mozzarelli, Andrea

2006-05-01

Computational tools utilizing a unique empirical modeling system based on the hydrophobic effect and the measurement of logP(o/w) (the partition coefficient for solvent transfer between 1-octanol and water) are described. The associated force field, Hydropathic INTeractions (HINT), contains much rich information about non-covalent interactions in the biological environment because of its basis in an experiment that measures interactions in solution. HINT is shown to be the core of an evolving virtual screening system that is capable of taking into account a number of factors often ignored such as entropy, effects of solvent molecules at the active site, and the ionization states of acidic and basic residues and ligand functional groups. The outline of a comprehensive modeling system for virtual screening that incorporates these features is described. In addition, a detailed description of the Computational Titration algorithm is provided. As an example, three complexes of dihydrofolate reductase (DHFR) are analyzed with our system and these results are compared with the experimental free energies of binding.

Optimal File-Distribution in Heterogeneous and Asymmetric Storage Networks

NASA Astrophysics Data System (ADS)

Langner, Tobias; Schindelhauer, Christian; Souza, Alexander

We consider an optimisation problem which is motivated from storage virtualisation in the Internet. While storage networks make use of dedicated hardware to provide homogeneous bandwidth between servers and clients, in the Internet, connections between storage servers and clients are heterogeneous and often asymmetric with respect to upload and download. Thus, for a large file, the question arises how it should be fragmented and distributed among the servers to grant "optimal" access to the contents. We concentrate on the transfer time of a file, which is the time needed for one upload and a sequence of n downloads, using a set of m servers with heterogeneous bandwidths. We assume that fragments of the file can be transferred in parallel to and from multiple servers. This model yields a distribution problem that examines the question of how these fragments should be distributed onto those servers in order to minimise the transfer time. We present an algorithm, called FlowScaling, that finds an optimal solution within running time {O}(m log m). We formulate the distribution problem as a maximum flow problem, which involves a function that states whether a solution with a given transfer time bound exists. This function is then used with a scaling argument to determine an optimal solution within the claimed time complexity.

Health Information National Trends Survey in American Sign Language (HINTS-ASL): Protocol for the Cultural Adaptation and Linguistic Validation of a National Survey.

PubMed

Kushalnagar, Poorna; Harris, Raychelle; Paludneviciene, Raylene; Hoglind, TraciAnn

2017-09-13

The Health Information National Trends Survey (HINTS) collects nationally representative data about the American's public use of health-related information. This survey is available in English and Spanish, but not in American Sign Language (ASL). Thus, the exclusion of ASL users from these national health information survey studies has led to a significant gap in knowledge of Internet usage for health information access in this underserved and understudied population. The objectives of this study are (1) to culturally adapt and linguistically translate the HINTS items to ASL (HINTS-ASL); and (2) to gather information about deaf people's health information seeking behaviors across technology-mediated platforms. We modified the standard procedures developed at the US National Center for Health Statistics Cognitive Survey Laboratory to culturally adapt and translate HINTS items to ASL. Cognitive interviews were conducted to assess clarity and delivery of these HINTS-ASL items. Final ASL video items were uploaded to a protected online survey website. The HINTS-ASL online survey has been administered to over 1350 deaf adults (ages 18 to 90 and up) who use ASL. Data collection is ongoing and includes deaf adult signers across the United States. Some items from HINTS item bank required cultural adaptation for use with deaf people who use accessible services or technology. A separate item bank for deaf-related experiences was created, reflecting deaf-specific technology such as sharing health-related ASL videos through social network sites and using video remote interpreting services in health settings. After data collection is complete, we will conduct a series of analyses on deaf people's health information seeking behaviors across technology-mediated platforms. HINTS-ASL is an accessible health information national trends survey, which includes a culturally appropriate set of items that are relevant to the experiences of deaf people who use ASL. The final HINTS-ASL product will be available for public use upon completion of this study. ©Poorna Kushalnagar. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 13.09.2017.

A hinting strategy for online learning of radiograph interpretation by medical students.

PubMed

Boutis, Kathy; Pecaric, Martin; Shiau, Maria; Ridley, Jane; P Gladding, Sophie; S Andrews, John; V Pusic, Martin

2013-09-01

We examined whether a 'hint' manoeuvre increases the time novice medical learners spend on reviewing a radiograph, thereby potentially increasing their interpretation accuracy. Senior year medical students were recruited into a randomised control, three-arm, multicentre trial. Students reviewed an online 50-case learning set that varied in degree of 'hint' intervention. The 'hint' was a dialogue box that appeared after a student submitted an answer, encouraging the student to re-evaluate their interpretation. The students in the control group received no hints. In the weak intervention group, students received 'hints' with 66% of their incorrect interpretations and 33% of those that were correct. In the strong intervention group, the incorrect interpretation hint frequency was 80%, whereas for correct responses it was 20%. All students completed a 20-case post-test immediately and 2 weeks after the 50 cases. The primary outcome was student performance on the immediate post-test, measured as the ability to discriminate between normal and abnormal films (dPrime). Secondary outcomes included the probability of considering the hint, time spent on learning cases and knowledge retention at 2 weeks. We enrolled 117 medical students from three sites into the three study groups: control (36), weak intervention (40) and strong intervention (41) groups. The mean (standard deviation) dPrime in the control, weak and strong groups were 0.4 (1.1), 0.7 (1.1) and 0.4 (0.9), respectively (P = 0.4). In the weak and strong groups, participants reconsidered answers in 556 of 1944 (28.6%) hinting opportunities, and those who reconsidered their answers spent a mean (95% confidence interval) of 13.9 (11.9, 16.0) seconds longer on each case. There were no significant differences in knowledge retention at 2 weeks between the groups (P = 0.2). Although the implemented hinting strategy did result in students spending more time considering a proportion of the cases, overall it was not effective in improving student performance. © John Wiley & Sons Ltd.

Navier-Stokes flowfield computation of wing/rotor interaction for a tilt rotor aircraft in hover

NASA Technical Reports Server (NTRS)

Fejtek, Ian G.

1993-01-01

The download on the wing produced by the rotor-induced downwash of a tilt rotor aircraft in hover is of major concern because of its severe impact on payload-carrying capability. A method has been developed to help gain a better understanding of the fundamental fluid dynamics that causes this download, and to help find ways to reduce it. In particular, the method is employed in this work to analyze the effect of a tangential leading edge circulation-control jet on download reduction. Because of the complexities associated with modeling the complete configuration, this work focuses specifically on the wing/rotor interaction of a tilt rotor aircraft in hover. The three-dimensional, unsteady, thin-layer compressible Navier-Stokes equations are solved using a time-accurate, implicit, finite difference scheme that employs LU-ADI factorization. The rotor is modeled as an actuator disk which imparts both a radical and an azimuthal distribution of pressure rise and swirl to the flowfield. A momentum theory blade element analysis of the rotor is incorporated into the Navier-Stokes solution method. Solution blanking at interior points of the mesh has been shown here to be an effective technique in introducing the effects of the rotor and tangential leading edge jet. Results are presented both for a rotor alone and for wing/rotor interaction. The overall mean characteristics of the rotor flowfield are computed including the flow acceleration through the rotor disk, the axial and swirl velocities in the rotor downwash, and the slipstream contraction. Many of the complex tilt rotor flow features are captured including the highly three-dimensional flow over the wing, the recirculation fountain at the plane of symmetry, wing leading and trailing edge separation, and the large region of separated flow beneath the wing. Mean wing surface pressures compare fairly well with available experimental data, but the time-averaged download/thrust ratio is 20-30 percent higher than the measured value. The discrepancy is due to a combination of factors that are discussed. Leading edge tangential blowing, of constant strength along the wing span, is shown to be effective in reducing download. The jet serves primarily to reduce the pressure on the wing upper surface. The computation clearly shows that, because of the three-dimensionality of the flowfield, optimum blowing would involve a spanwise variation in blowing strength.

76 FR 37356 - Submission for OMB review; comment request Health Information National Trends Survey 4 (HINTS 4...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

...; comment request Health Information National Trends Survey 4 (HINTS 4) (NCI) Summary: Under the provisions... control number. Proposed Collection: Title: Health Information National Trends Survey 4 (HINTS 4) (NCI... the table below. There are no Capital Costs, Operating Costs, and/or Maintenance Costs to report...

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human histidine triad nucleotide-binding protein 2 (hHINT2)

PubMed Central

Dolot, Rafał; Włodarczyk, Artur; Bujacz, Grzegorz D.; Nawrot, Barbara

2013-01-01

Histidine triad nucleotide-binding protein 2 (HINT2) is a mitochondrial adenosine phosphoramidase mainly expressed in the pancreas, liver and adrenal gland. HINT2 possibly plays a role in apoptosis, as well as being involved in steroid biosynthesis, hepatic lipid metabolism and regulation of hepatic mitochondria function. The expression level of HINT2 is significantly down-regulated in hepatocellular carcinoma patients. To date, endogenous substrates for this enzyme, as well as the three-dimensional structure of human HINT2, are unknown. In this study, human HINT2 was cloned, overexpressed in Escherichia coli and purified. Crystallization was performed at 278 K using PEG 4000 as the main precipitant; the crystals, which belonged to the tetragonal space group P41212 with unit-cell parameters a = b = 76.38, c = 133.25 Å, diffracted to 2.83 Å resolution. Assuming two molecules in the asymmetric unit, the Matthews coefficient and the solvent content were calculated to be 2.63 Å3 Da−1 and 53.27%, respectively. PMID:23832208

Managing an archive of weather satellite images

NASA Technical Reports Server (NTRS)

Seaman, R. L.

1992-01-01

The author's experiences of building and maintaining an archive of hourly weather satellite pictures at NOAO are described. This archive has proven very popular with visiting and staff astronomers - especially on windy days and cloudy nights. Given access to a source of such pictures, a suite of simple shell and IRAF CL scripts can provide a great deal of robust functionality with little effort. These pictures and associated data products such as surface analysis (radar) maps and National Weather Service forecasts are updated hourly at anonymous ftp sites on the Internet, although your local Atsmospheric Sciences Department may prove to be a more reliable source. The raw image formats are unfamiliar to most astronomers, but reading them into IRAF is straightforward. Techniques for performing this format conversion at the host computer level are described which may prove useful for other chores. Pointers are given to sources of data and of software, including a package of example tools. These tools include shell and Perl scripts for downloading pictures, maps, and forecasts, as well as IRAF scripts and host level programs for translating the images into IRAF and GIF formats and for slicing & dicing the resulting images. Hints for displaying the images and for making hardcopies are given.

Acting the Intangible: Hints of Politeness in Non-Verbal Form

ERIC Educational Resources Information Center

Jumanto, Jumanto; Rizal, Sarif Syamsu; Nugroho, Raden Arief

2017-01-01

This review paper has explored politeness in non-verbal form to come to hints for indicating the ideology. Politeness in non-verbal form is researched by reviewing verbal politeness theories through interpretive techniques, and then the data in form of interpreted hints based on the reviews are analyzed by employing a coding technique. The six…

Understanding Attention to Adaptive Hints in Educational Games: An Eye-Tracking Study

ERIC Educational Resources Information Center

Conati, Cristina; Jaques, Natasha; Muir, Mary

2013-01-01

This paper presents a user study that investigates the factors affecting student attention to user-adaptive hints during interaction with an educational computer game. The study focuses on Prime Climb, an educational game designed to provide individualized support for learning number factorization skills in the form of textual hints based on a…

Switch-on fluorescent/FRET probes to study human histidine triad nucleotide binding protein 1 (hHint1), a novel target for opioid tolerance and neuropathic pain.

PubMed

Shah, Rachit; Zhou, Andrew; Wagner, Carston R

2017-12-13

Histidine Triad Nucleotide Binding Protein 1 (Hint1) has emerged to be an important post-synaptic protein associated with a variety of central nervous system disorders such as pain, addiction, and schizophrenia. Recently, inhibition of histidine nucleotide binding protein 1 (Hint1) with a small nucleoside inhibitor has shown promise as a new therapeutic strategy for the treatment of neuropathic pain. Herein, we describe the first rationally designed small molecule switch-on probes with dual fluorescence and FRET properties to study Hint1. Two non-natural fluorescent nucleosides with a fluorescent lifetime of 20 and 25 ns were each coupled through a linker to the indole ring, i.e. probes 7 and 8. Both probes were found to be water soluble and quenched intramolecularly via photoinduced electron transfer (PET) resulting in minimal background fluorescence. Upon incubating with Hint1, compound 7 and 8 exhibited a 40- and 16-fold increase in the fluorescence intensity compared to the control. Compounds 7 and 8 bind Hint1 with a dissociation constant of 0.121 ± 0.02 and 2.2 ± 0.36 μM, respectively. We demonstrate that probe 8 exhibits a switch-on FRET property with an active site tryptophan residue (W123). We show the utility of probes in performing quantitative ligand displacement studies, as well as in selective detection of Hint1 in the cell lysates. These probes should be useful for studying the dynamics of the active site, as well as for the development of fluorescence lifetime based high throughput screening assay to identify novel inhibitors for Hint1 in future.

Stoic Behavior Hypothesis in Hint Seeking and Development of Reversi Learning Environment as Work Bench for Investigation

ERIC Educational Resources Information Center

Miwa, Kazuhisa; Kojima, Kazuaki; Terai, Hitoshi

2014-01-01

Tutoring systems provide students with various types of on-demand and context-sensitive hints. Students are required to consciously adapt their help-seeking behavior, proactively seek help in some situations, and solve problems independently without supports in other situations. We define the latter behavior as stoic behavior in hint seeking. In…

Financial model calibration using consistency hints.

PubMed

Abu-Mostafa, Y S

2001-01-01

We introduce a technique for forcing the calibration of a financial model to produce valid parameters. The technique is based on learning from hints. It converts simple curve fitting into genuine calibration, where broad conclusions can be inferred from parameter values. The technique augments the error function of curve fitting with consistency hint error functions based on the Kullback-Leibler distance. We introduce an efficient EM-type optimization algorithm tailored to this technique. We also introduce other consistency hints, and balance their weights using canonical errors. We calibrate the correlated multifactor Vasicek model of interest rates, and apply it successfully to Japanese Yen swaps market and US dollar yield market.

Automated bond order assignment as an optimization problem.

PubMed

Dehof, Anna Katharina; Rurainski, Alexander; Bui, Quang Bao Anh; Böcker, Sebastian; Lenhof, Hans-Peter; Hildebrandt, Andreas

2011-03-01

Numerous applications in Computational Biology process molecular structures and hence strongly rely not only on correct atomic coordinates but also on correct bond order information. For proteins and nucleic acids, bond orders can be easily deduced but this does not hold for other types of molecules like ligands. For ligands, bond order information is not always provided in molecular databases and thus a variety of approaches tackling this problem have been developed. In this work, we extend an ansatz proposed by Wang et al. that assigns connectivity-based penalty scores and tries to heuristically approximate its optimum. In this work, we present three efficient and exact solvers for the problem replacing the heuristic approximation scheme of the original approach: an A*, an ILP and an fixed-parameter approach (FPT) approach. We implemented and evaluated the original implementation, our A*, ILP and FPT formulation on the MMFF94 validation suite and the KEGG Drug database. We show the benefit of computing exact solutions of the penalty minimization problem and the additional gain when computing all optimal (or even suboptimal) solutions. We close with a detailed comparison of our methods. The A* and ILP solution are integrated into the open-source C++ LGPL library BALL and the molecular visualization and modelling tool BALLView and can be downloaded from our homepage www.ball-project.org. The FPT implementation can be downloaded from http://bio.informatik.uni-jena.de/software/.

GIS Data Downloads | USDA Plant Hardiness Zone Map

Science.gov Websites

Acknowledgments & Citation Copyright Map & Data Downloads Map Downloads Geography (GIS) Downloads Multi & Data Downloads / GIS Data Downloads Topics Map Downloads Geography (GIS) Downloads Multi-Zip Code

Axonal neuropathy with neuromyotonia: there is a HINT.

PubMed

Peeters, Kristien; Chamova, Teodora; Tournev, Ivailo; Jordanova, Albena

2017-04-01

Recessive mutations in the gene encoding the histidine triad nucleotide binding protein 1 (HINT1) were recently shown to cause a motor-predominant Charcot-Marie-Tooth neuropathy. About 80% of the patients exhibit neuromyotonia, a striking clinical and electrophysiological hallmark that can help to distinguish this disease and to guide diagnostic screening. HINT1 neuropathy has worldwide distribution and is particularly prevalent in populations inhabiting central and south-eastern Europe. With 12 different mutations identified in more than 60 families, it ranks among the most common subtypes of axonal Charcot-Marie-Tooth neuropathy. This article provides an overview of the present knowledge on HINT1 neuropathy with the aim to increase awareness and spur interest among clinicians and researchers in the field. We propose diagnostic guidelines to recognize and differentiate this entity and suggest treatment strategies to manage common symptoms. As a recent player in the field of hereditary neuropathies, the role of HINT1 in peripheral nerves is unknown and the underlying disease mechanisms are unexplored. We provide a comprehensive overview of the structural and functional characteristics of the HINT1 protein that may guide further studies into the molecular aetiology and treatment strategies of this peculiar Charcot-Marie-Tooth subtype. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

A Nonresponse Bias Analysis of the Health Information National Trends Survey (HINTS).

PubMed

Maitland, Aaron; Lin, Amy; Cantor, David; Jones, Mike; Moser, Richard P; Hesse, Bradford W; Davis, Terisa; Blake, Kelly D

2017-07-01

We conducted a nonresponse bias analysis of the Health Information National Trends Survey (HINTS) 4, Cycles 1 and 3, collected in 2011 and 2013, respectively, using three analysis methods: comparison of response rates for subgroups, comparison of estimates with weighting adjustments and external benchmarks, and level-of-effort analysis. Areas with higher concentrations of low socioeconomic status, higher concentrations of young households, and higher concentrations of minority and Hispanic populations had lower response rates. Estimates of health information seeking behavior were higher in HINTS compared to the National Health Interview Survey (NHIS). The HINTS estimate of doctors always explaining things in a way that the patient understands was not significantly different from the same estimate from the Medical Expenditure Panel Survey (MEPS); however, the HINTS estimate of health professionals always spending enough time with the patient was significantly lower than the same estimate from MEPS. A level-of-effort analysis found that those who respond later in the survey field period were less likely to have looked for information about health in the past 12 months, but found only small differences between early and late respondents for the majority of estimates examined. There is some evidence that estimates from HINTS could be biased toward finding higher levels of health information seeking.

Exploring item and higher order factor structure with the Schmid-Leiman solution: syntax codes for SPSS and SAS.

PubMed

Wolff, Hans-Georg; Preising, Katja

2005-02-01

To ease the interpretation of higher order factor analysis, the direct relationships between variables and higher order factors may be calculated by the Schmid-Leiman solution (SLS; Schmid & Leiman, 1957). This simple transformation of higher order factor analysis orthogonalizes first-order and higher order factors and thereby allows the interpretation of the relative impact of factor levels on variables. The Schmid-Leiman solution may also be used to facilitate theorizing and scale development. The rationale for the procedure is presented, supplemented by syntax codes for SPSS and SAS, since the transformation is not part of most statistical programs. Syntax codes may also be downloaded from www.psychonomic.org/archive/.

Pitfalls and Rewards for Implementing Ocular Motor Testing in Acute Vestibular Syndrome: A Pilot Project

PubMed Central

Dumitrascu, Oana M.; Torbati, Sam; Tighiouart, Mourad; Newman-Toker, David E.; Song, Shlee S.

2016-01-01

Objectives Isolated Acute Vestibular Syndrome (iAVS) presentations to the Emergency Department (ED) pose management challenges given concerns for posterior circulation strokes. False negative brain imaging may erroneously reassure clinicians, while HINTS-plus examination outperforms imaging to screen for strokes in iAVS. We studied the feasibility of implementing HINTS-plus testing in the ED, aiming to reduce neuroimaging in patients with iAVS. Methods We launched an institutional Quality Improvement initiative, using DMAIC methodology. The outcome measures (proportion of iAVS subjects that had HINTS-plus examinations and underwent neuroimaging by CT/MRI) were compared before and after the established intervention. The intervention consisted of formal training for neurologists and emergency physicians on how to perform, document, and interpret HINTS-plus and implementation of novel iAVS management algorithm. Neuroimaging was not recommended if HINTS-plus suggested peripheral vestibular etiology. If a central process was suspected, brain MRI/MR angiogram was performed. Head CT was reserved only for thrombolytic time-window cases. Results In the first 2 months post-implementation, HINTS-plus testing performance by neurologists increased from 0% to 80% (p = 0.007), and by ED providers from 0% to 9.09% (p = 0.367). Head CT scans were reduced from 18.5% to 6. 25%. Brain MRI use was reduced from 51.8% to 31.2%. 60% of the iAVS subjects were discharged from the ED; none were readmitted or had another ED presentation in the ensuing 30 days. Conclusions Implementation of HINTS-plus evaluation in the ED is valuable and feasible for neurologists, but challenging for emergency physicians. Future studies should determine the ‘dose-response’ curve of educational interventions. PMID:28248913

Pitfalls and Rewards for Implementing Ocular Motor Testing in Acute Vestibular Syndrome: A Pilot Project.

PubMed

Dumitrascu, Oana M; Torbati, Sam; Tighiouart, Mourad; Newman-Toker, David E; Song, Shlee S

2017-03-01

Isolated acute vestibular syndrome (iAVS) presentations to the emergency department (ED) pose management challenges, given the concerns for posterior circulation strokes. False-negative brain imaging may erroneously reassure clinicians, whereas HINTS-plus examination outperforms imaging to screen for strokes in iAVS. We studied the feasibility of implementing HINTS-plus testing in the ED, aiming to reduce neuroimaging in patients with iAVS. We launched an institutional Quality Improvement initiative, using DMAIC methodology. The outcome measures [proportion of iAVS subjects who had HINTS-plus examinations and underwent neuroimaging by computed tomography/magnetic resonance imaging (CT/MRI)] were compared before and after the established intervention. The intervention consisted of formal training for neurologists and emergency physicians on how to perform, document, and interpret HINTS-plus and implementation of novel iAVS management algorithm. Neuroimaging was not recommended if HINTS-plus suggested peripheral vestibular etiology. If a central process was suspected, brain MRI/MR angiogram was performed. Head CT was reserved only for thrombolytic time-window cases. In the first 2 months postimplementation, HINTS-plus testing performance by neurologists increased from 0% to 80% (P=0.007), and by ED providers from 0% to 9.09% (P=0.367). Head CT scans were reduced from 18.5% to 6.25%. Brain MRI use was reduced from 51.8% to 31.2%. About 60% of the iAVS subjects were discharged from the ED; none were readmitted or had another ED presentation in the ensuing 30 days. Implementation of HINTS-plus evaluation in the ED is valuable and feasible for neurologists, but challenging for emergency physicians. Future studies should determine the "dose-response" curve of educational interventions.

HINTS Puerto Rico: Final Report

Cancer.gov

This final report describes HINTS implementation in Puerto Rico. The report addresses sampling; staffing, training and management of data collection; calling protocol; findings from the CATI Operations, and sample weights.

Construction of 3-D Earth Models for Station Specific Path Corrections by Dynamic Ray Tracing

DTIC Science & Technology

2001-10-01

the numerical eikonal solution method of Vidale (1988) being used by the MIT led consortium. The model construction described in this report relies...assembled. REFERENCES Barazangi, M., Fielding, E., Isacks, B. & Seber, D., (1996), Geophysical And Geological Databases And Ctbt...preprint download6). Fielding, E., Isacks, B.L., and Baragangi. M. (1992), A Network Accessible Geological and Geophysical Database for

Site Map | USDA Plant Hardiness Zone Map

Science.gov Websites

Acknowledgments & Citation Copyright Map & Data Downloads Map Downloads Geography (GIS) Downloads Multi ; Citation Copyright Map & Data Downloads Map Downloads Geography (GIS) Downloads Multi-ZIP Code Finder

Active Learning Using Hint Information.

PubMed

Li, Chun-Liang; Ferng, Chun-Sung; Lin, Hsuan-Tien

2015-08-01

The abundance of real-world data and limited labeling budget calls for active learning, an important learning paradigm for reducing human labeling efforts. Many recently developed active learning algorithms consider both uncertainty and representativeness when making querying decisions. However, exploiting representativeness with uncertainty concurrently usually requires tackling sophisticated and challenging learning tasks, such as clustering. In this letter, we propose a new active learning framework, called hinted sampling, which takes both uncertainty and representativeness into account in a simpler way. We design a novel active learning algorithm within the hinted sampling framework with an extended support vector machine. Experimental results validate that the novel active learning algorithm can result in a better and more stable performance than that achieved by state-of-the-art algorithms. We also show that the hinted sampling framework allows improving another active learning algorithm designed from the transductive support vector machine.

Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia.

PubMed

Shah, Rachit M; Maize, Kimberly M; West, Harrison T; Strom, Alexander M; Finzel, Barry C; Wagner, Carston R

2018-05-19

Inherited peripheral neuropathies are a group of neurodegenerative disorders that clinically affect 1 in 2500 individuals. Recently, genetic mutations in human histidine nucleotide-binding protein 1 (hHint1) have been strongly and most frequently associated with patients suffering from axonal neuropathy with neuromyotonia. However, the correlation between the impact of these mutations on the hHint1 structure, enzymatic activity and in vivo function has remained ambiguous. Here, we provide detailed biochemical characterization of a set of these hHint1 mutations. Our findings indicate that half of the mutations (R37P, G93D and W123*) resulted in a destabilization of the dimeric state and a significant decrease in catalytic activity and HINT1 inhibitor binding affinity. The H112N mutant was found to be dimeric, but devoid of catalytic activity, due to the loss of the catalytically essential histidine; nevertheless, it exhibited high affinity to AMP and a HINT1 inhibitor. In contrast to the active-site mutants, the catalytic activity and dimeric structure of the surface mutants, C84R and G89V, were found to be similar to the wild-type enzyme. Taken together, our results suggest that the pathophysiology of inherited axonal neuropathy with neuromyotonia can be induced by conversion of HINT1 from a homodimer to monomer, by modification of select surface residues or by a significant reduction of the enzyme's catalytic efficiency. Copyright © 2018. Published by Elsevier Ltd.

Sense of Accomplishment Is Modulated by a Proper Level of Instruction and Represented in the Brain Reward System.

PubMed

Nakai, Tomoya; Nakatani, Hironori; Hosoda, Chihiro; Nonaka, Yulri; Okanoya, Kazuo

2017-01-01

Problem-solving can be facilitated with instructions or hints, which provide information about given problems. The proper amount of instruction that should be provided for learners is controversial. Research shows that tasks with intermediate difficulty induce the largest sense of accomplishment (SA), leading to an intrinsic motivation for learning. To investigate the effect of instructions, we prepared three instruction levels (No hint, Indirect hint, and Direct hint) for the same insight-problem types. We hypothesized that indirect instructions impose intermediate difficulty for each individual, thereby inducing the greatest SA per person. Based on previous neuroimaging studies that showed involvement of the bilateral caudate in learning and motivation, we expected SA to be processed in this reward system. We recruited twenty-one participants, and investigated neural activations during problem solving by functional magnetic resonance imaging (fMRI). We confirmed that the Indirect hint, which imposed intermediate difficulty, induced the largest SA among the three instruction types. Using fMRI, we showed that activations in the bilateral caudate and anterior cingulate cortex (ACC) were significantly modulated by SA. In the bilateral caudate, the indirect hint induced the largest activation, while the ACC seemed to reflect the difference between correct and incorrect trials. Importantly, such activation pattern was independent of notations (number or letter). Our results indicate that SA is represented in the reward system, and that the Indirect instruction effectively induces such sensation.

Sense of Accomplishment Is Modulated by a Proper Level of Instruction and Represented in the Brain Reward System

PubMed Central

Nakai, Tomoya; Nakatani, Hironori; Hosoda, Chihiro; Nonaka, Yulri; Okanoya, Kazuo

2017-01-01

Problem-solving can be facilitated with instructions or hints, which provide information about given problems. The proper amount of instruction that should be provided for learners is controversial. Research shows that tasks with intermediate difficulty induce the largest sense of accomplishment (SA), leading to an intrinsic motivation for learning. To investigate the effect of instructions, we prepared three instruction levels (No hint, Indirect hint, and Direct hint) for the same insight-problem types. We hypothesized that indirect instructions impose intermediate difficulty for each individual, thereby inducing the greatest SA per person. Based on previous neuroimaging studies that showed involvement of the bilateral caudate in learning and motivation, we expected SA to be processed in this reward system. We recruited twenty-one participants, and investigated neural activations during problem solving by functional magnetic resonance imaging (fMRI). We confirmed that the Indirect hint, which imposed intermediate difficulty, induced the largest SA among the three instruction types. Using fMRI, we showed that activations in the bilateral caudate and anterior cingulate cortex (ACC) were significantly modulated by SA. In the bilateral caudate, the indirect hint induced the largest activation, while the ACC seemed to reflect the difference between correct and incorrect trials. Importantly, such activation pattern was independent of notations (number or letter). Our results indicate that SA is represented in the reward system, and that the Indirect instruction effectively induces such sensation. PMID:28052091

SlugIn 1.0: A Free Tool for Automated Slug Test Analysis.

PubMed

Martos-Rosillo, Sergio; Guardiola-Albert, Carolina; Padilla Benítez, Alberto; Delgado Pastor, Joaquín; Azcón González, Antonio; Durán Valsero, Juan José

2018-05-01

The correct characterization of aquifer parameters is essential for water-supply and water-quality investigations. Slug tests are widely used for these purposes. While free software is available to interpret slug tests, some codes are not user-friendly, or do not include a wide range of methods to interpret the results, or do not include automatic, inverse solutions to the test data. The private sector has also generated several good programs to interpret slug test data, but they are not free of charge. The computer program SlugIn 1.0 is available online for free download, and is demonstrated to aid in the analysis of slug tests to estimate hydraulic parameters. The program provides an easy-to-use Graphical User Interface. SlugIn 1.0 incorporates automated parameter estimation and facilitates the visualization of several interpretations of the same test. It incorporates solutions for confined and unconfined aquifers, partially penetrating wells, skin effects, shape factor, anisotropy, high hydraulic conductivity formations and the Mace test for large-diameter wells. It is available in English and Spanish and can be downloaded from the web site of the Geological Survey of Spain. Two field examples are presented to illustrate how the software operates. © 2018, National Ground Water Association.

Astrophysical hints of axion-like particles

NASA Astrophysics Data System (ADS)

Roncadelli, M.; Galanti, G.; Tavecchio, F.; Bonnoli, G.

2015-01-01

After reviewing three astrophysical hints of the existence of axion-like particles (ALPs), we describe in more detail a new similar hint involving flat spectrum radio quasars (FSRQs). Detection of FSRQs above about 20GeV pose a challenge to very-high-energy (VHE) astrophysics, because at those energies the ultraviolet emission from their broad line region should prevent photons produced by the central engine to leave the source. Although a few astrophysical explanations have been put forward, they are totally ad hoc. We show that a natural explanation instead arises within the conventional models of FSRQs provided that photon-ALP oscillations occur inside the source. Our analysis takes the FSRQ PKR 1222+206 as an example, and it looks tantalizing that basically the same choice of the free model parameters adopted in this case is consistent with those that provide the other three hints of the existence of ALPs.

DiTour

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pelaia, II, Thomas A.

2014-06-05

it is common for facilities to have a lobby with a display loop while also requiring an option for guided tours. Existing solutions have required expensive hardware and awkward software. Our solution is relative low cost as it runs on an iPad connected to an external monitor, and our software provides an intuitive touch interface. The media files are downloaded from a web server onto the device allowing a mobile option (e.g. displays at conferences). Media may include arbitrary sequences of images, movies or PDF documents. Tour guides can select different tracks of slides to display and the presentation willmore » return to the default loop after a timeout.« less

Solvent effects on static and dynamic polarizability and hyperpolarizabilities of acetonitrile

NASA Astrophysics Data System (ADS)

Cammi, Roberto; Cossi, Maurizio; Mennucci, Benedetta; Tomasi, Jacopo

1997-12-01

An application of the theory recently developed to calculate SCF static and dynamic (hyper)polarizabilities of molecular solutes within the framework of the polarizable continuum model is presented here. The specific system under analysis is given by the acetonitrile molecule both in vacuo and in two different dilute solutions, water and benzene. The numerical results reported in the present paper are focused on an evaluation of the main changes produced by the presence of a solvent on the static and dynamic polarizability, α, and first and second hyperpolarizabilities, β and ρ, with respect to the corresponding quantities in the gas phase. The limits of the present calculations, and the prospects for their refinement, are discussed with a view to giving a preliminary hint and a first tool for future reliable prediction of the behavior of this kind of response function when the molecule is perturbed by the presence of a surrounding medium.

Can xenon in water inhibit ice growth? Molecular dynamics of phase transitions in water-Xe system.

PubMed

Artyukhov, Vasilii I; Pulver, Alexander Yu; Peregudov, Alex; Artyuhov, Igor

2014-07-21

Motivated by recent experiments showing the promise of noble gases as cryoprotectants, we perform molecular dynamics modeling of phase transitions in water with xenon under cooling. We follow the structure and dynamics of xenon water solution as a function of temperature. Homogeneous nucleation of clathrate hydrate phase is observed and characterized. As the temperature is further reduced we observe hints of dissociation of clathrate due to stronger hydrophobic hydration, pointing towards a possible instability of clathrate at cryogenic temperatures and conversion to an amorphous phase comprised of "xenon + hydration shell" Xe·(H2O)21.5 clusters. Simulations of ice-xenon solution interface in equilibrium and during ice growth reveal the effects of xenon on the ice-liquid interface, where adsorbed xenon causes roughening of ice surface but does not preferentially form clathrate. These results provide evidence against the ice-blocker mechanism of xenon cryoprotection.

Insights into water-mediated ion clustering in aqueous CaSO4 solutions: pre-nucleation cluster characteristics studied by ab initio calculations and molecular dynamics simulations.

PubMed

Li, Hui-Ji; Yan, Dan; Cai, Hou-Qin; Yi, Hai-Bo; Min, Xiao-Bo; Xia, Fei-Fei

2017-05-10

The molecular structure of growth units building crystals is a fundamental issue in the crystallization processes from aqueous solutions. In this work, a systematic investigation of pre-nucleation clusters and their hydration characteristics in aqueous CaSO 4 solutions was performed using ab initio calculations and molecular dynamics (MD) simulations. The results of ab initio calculations and MD simulations indicate that the dominant species in aqueous CaSO 4 solutions are monodentate ion-associated structures. Compared with charged ion clusters, neutral clusters are more likely to be present in an aqueous CaSO 4 solution. Neutral (CaSO 4 ) m clusters are probably the growth units involved in the pre-nucleation or crystallization processes. Meanwhile, hydration behavior around ion associated species in aqueous CaSO 4 solutions plays an important role in related phase/polymorphism selections. Upon ion clustering, the residence of some water molecules around Ca 2+ in ion-associated species is weakened while that of some bridging waters is enhanced due to dual interaction by Ca 2+ and SO 4 2- . Some phase/polymorphism selections can be achieved in aqueous CaSO 4 solutions by controlling the hydration around pre-nucleation clusters. Moreover, the association trend between calcium and sulfate is found to be relatively strong, which hints at the low solubility of calcium sulfate in water.

Principal Investigator in a Box Technical Description Document. 2.0

NASA Technical Reports Server (NTRS)

Groleau, Nick; Frainier, Richard

1994-01-01

This document provides a brief overview of the PI-in-a-Box system, which can be used for automatic real-time reaction to incoming data. We will therefore outline the current system's capabilities and limitations, and hint at how best to think about PI-in-a-Box as a tool for real-time analysis and reaction in section two, below. We also believe that the solution to many commercial real-time process problems requires data acquisition and analysis combined with rule-based reasoning and/or an intuitive user interface. We will develop the technology reuse potential in section three. Currently, the system runs only on Apple Computer's Macintosh series.

25 CFR 547.12 - What are the minimum technical standards for downloading on a Class II gaming system?

Code of Federal Regulations, 2013 CFR

2013-04-01

... limited to software, files, data, and prize schedules. (2) Downloads must use secure methodologies that... date of the completion of the download; (iii) The Class II gaming system components to which software was downloaded; (iv) The version(s) of download package and any software downloaded. Logging of the...

25 CFR 547.12 - What are the minimum technical standards for downloading on a Class II gaming system?

Code of Federal Regulations, 2014 CFR

2014-04-01

... limited to software, files, data, and prize schedules. (2) Downloads must use secure methodologies that... date of the completion of the download; (iii) The Class II gaming system components to which software was downloaded; (iv) The version(s) of download package and any software downloaded. Logging of the...

Evident or doubtful? How lexical hints in written information influence laypersons' understanding of influenza.

PubMed

Mayweg-Paus, Elisabeth; Jucks, Regina

2015-01-01

There are clear differences in the way written information on health issues presents research findings. In some cases, the source of a piece of information (e.g. "expert professor") is highlighted to emphasize its credibility and relevance. In other cases, the impact of a certain argument is stressed by avoiding hints on tentativeness such as "mostly" or "up to now." This article examines whether and how far such differences influence laypersons' comprehension of the contents provided. In an experimental setting, 157 laypersons were asked to read an online article on a new approach to preventing influenza. The texts manipulated whether there were (a) hints on the source of information and (b) lexical hints on the tentativeness of the information (hedges). After reading the text, participants were asked to write an essay reporting their opinion on the topic. Their argumentation on vaccination was assessed with content analysis and their attitudes toward vaccination were surveyed with a questionnaire. Results indicated that when lexical hints were given, tentativeness led participants to focus more on the actual information in the text. Additionally, decisions more strongly favored the direction implied in the text when the source of the medical information was not reported. Consequences for the way health information should be presented to laypersons are discussed.

Alternative Fuels Data Center: Data Downloads

Science.gov Websites

Data Downloads to someone by E-mail Share Alternative Fuels Data Center: Data Downloads on Facebook Tweet about Alternative Fuels Data Center: Data Downloads on Twitter Bookmark Alternative Fuels Data Center: Data Downloads on Google Bookmark Alternative Fuels Data Center: Data Downloads on Delicious Rank

From petascale to exascale, the future of simulated climate data (Invited)

NASA Astrophysics Data System (ADS)

Lawrence, B.; Juckes, M. N.

2013-12-01

Coleridge ought to have said: data, data, everywhere, and all the data centres groan, data data everywhere, nor any I should clone. Except of course, he didn't say it, and we do clone data! While we've been dealing with terabytes of simulated datasets, downloading ("cloning") and analysing, has been a plausible way forward. In doing so, we have set up systems that support four broad classes of activities: personal and institutional data analysis, federated data systems, and data portals. We use metadata to manage the migration of data between these (and their communities) and we have built software systems. However, our metadata and software solutions are fragile, often based on soft money, and loose governance arrangements. We often download data with minimal provenance, and often many of us download the same data. In the not too distant future we can imagine exabytes of data being produced, and all these problems will get worse. Arguably we have no plausible methods of effectively exploiting such data - particularly if the analysis requires intercomparison. Yet of course, we know full well that intercomparison is at the heart of climate science. In this talk, we review the current status of simulation data management, with special emphasis on accessibility and usability. We talk about file formats, bundles of files, real and virtual, and simulation metadata. We introduce the InfraStructure for the European Network for Earth Simulation (IS-ENES) and its relationship with the Earth System Grid Federation (ESGF) as well as JASMIN, the UK Joint Analysis System. There will be a small digression on parallel data analysis - locally and distributed. we then progress to the near term problems (and solutions) for climate data before scoping out the problems of the future, both for data handling, and the models that produce the data. The way we think about data, computing, models, even ensemble design, may need to change.

"Don't know" responses to risk perception measures: implications for underserved populations.

PubMed

Waters, Erika A; Hay, Jennifer L; Orom, Heather; Kiviniemi, Marc T; Drake, Bettina F

2013-02-01

Risk perceptions are legitimate targets for behavioral interventions because they can motivate medical decisions and health behaviors. However, some survey respondents may not know (or may not indicate) their risk perceptions. The scope of "don't know" (DK) responding is unknown. Examine the prevalence and correlates of responding DK to items assessing perceived risk of colorectal cancer. Two nationally representative, population-based, cross-sectional surveys (2005 National Health Interview Survey [NHIS]; 2005 Health Information National Trends Survey [HINTS]), and one primary care clinic-based survey comprised of individuals from low-income communities. Analyses included 31,202 (NHIS), 1,937 (HINTS), and 769 (clinic) individuals. Five items assessed perceived risk of colorectal cancer. Four of the items differed in format and/or response scale: comparative risk (NHIS, HINTS); absolute risk (HINTS, clinic), and "likelihood" and "chance" response scales (clinic). Only the clinic-based survey included an explicit DK response option. "Don't know" responding was 6.9% (NHIS), 7.5% (HINTS-comparative), and 8.7% (HINTS-absolute). "Don't know" responding was 49.1% and 69.3% for the "chance" and "likely" response options (clinic). Correlates of DK responding were characteristics generally associated with disparities (e.g., low education), but the pattern of results varied among samples, question formats, and response scales. The surveys were developed independently and employed different methodologies and items. Consequently, the results were not directly comparable. There may be multiple explanations for differences in the magnitude and characteristics of DK responding. "Don't know" responding is more prevalent in populations affected by health disparities. Either not assessing or not analyzing DK responses could further disenfranchise these populations and negatively affect the validity of research and the efficacy of interventions seeking to eliminate health disparities.

Current Development at the Southern California Earthquake Data Center (SCEDC)

NASA Astrophysics Data System (ADS)

Appel, V. L.; Clayton, R. W.

2005-12-01

Over the past year, the SCEDC completed or is near completion of three featured projects: Station Information System (SIS) Development: The SIS will provide users with an interface into complete and accurate station metadata for all current and historic data at the SCEDC. The goal of this project is to develop a system that can interact with a single database source to enter, update and retrieve station metadata easily and efficiently. The system will provide accurate station/channel information for active stations to the SCSN real-time processing system, as will as station/channel information for stations that have parametric data at the SCEDC i.e., for users retrieving data via STP. Additionally, the SIS will supply information required to generate dataless SEED and COSMOS V0 volumes and allow stations to be added to the system with a minimum, but incomplete set of information using predefined defaults that can be easily updated as more information becomes available. Finally, the system will facilitate statewide metadata exchange for both real-time processing and provide a common approach to CISN historic station metadata. Moment Tensor Solutions: The SCEDC is currently archiving and delivering Moment Magnitudes and Moment Tensor Solutions (MTS) produced by the SCSN in real-time and post-processing solutions for events spanning back to 1999. The automatic MTS runs on all local events with magnitudes > 3.0, and all regional events > 3.5. The distributed solution automatically creates links from all USGS Simpson Maps to a text e-mail summary solution, creates a .gif image of the solution, and updates the moment tensor database tables at the SCEDC. Searchable Scanned Waveforms Site: The Caltech Seismological Lab has made available 12,223 scanned images of pre-digital analog recordings of major earthquakes recorded in Southern California between 1962 and 1992 at http://www.data.scec.org/research/scans/. The SCEDC has developed a searchable web interface that allows users to search the available files, select multiple files for download and then retrieve a zipped file containing the results. Scanned images of paper records for M>3.5 southern California earthquakes and several significant teleseisms are available for download via the SCEDC through this search tool.

Network Security Risks of Online Social Networking in the Workplace

DTIC Science & Technology

2013-11-01

Facebook explains pornographic shock spam, hints at browser vulnera- bility, nakedsecurity. URL – http://nakedsecurity.sophos.com/2011/11/16/ facebook...explains- pornographic -shock-spam-hints-at-browser-vul nerability/. 22 UNCLASSIFIED UNCLASSIFIED DSTO–GD–0772 44. Blatz, J. (2011) CSRF: attack and

Downloading from the OPAC: The Innovative Interfaces Environment.

ERIC Educational Resources Information Center

Spore, Stuart

1991-01-01

Discussion of downloading from online public access catalogs focuses on downloading to MS-DOS microcomputers from the INNOPAC online catalog system. Tools for capturing and postprocessing downloaded files are described, technical and institutional constraints on downloading are addressed, and an innovative program for overcoming such constraints…

College Students' Moral Evaluations of Illegal Music Downloading

ERIC Educational Resources Information Center

Jambon, Marc M.; Smetana, Judith G.

2012-01-01

Although unauthorized music downloading is illegal, a majority of college students have downloaded music for free online. Evaluations of illegal music downloading and their association with downloading behavior were examined using social domain theory in a sample of 188 ethnically diverse college students (M[subscript age] = 19.80 years, SD =…

Pigeons (Columba livia) know when they will need hints: prospective metacognition for reference memory?

PubMed

Iwasaki, Sumie; Watanabe, Sota; Fujita, Kazuo

2018-03-01

Despite their impressive cognitive abilities, avian species have shown less evidence for metacognition than mammals. We suspect that commonly used tasks such as matching to sample might be too demanding to allow metacognitive processing within birds' working memory. Here, we examined whether pigeons could control their behavior as a function of knowledge levels on a three-item sequence learning task, a reference memory task supposedly requiring fewer working memory resources. The experiment used two types of lists differing in familiarity. One was familiar to the pigeons through repeated exposure, whereas the other was novel in every new session. In test sessions, pigeons could choose between a trial with a hint specifying the next item to peck and one with no hint. However, successful responses in trials with a hint resulted in lowered rates of primary reinforcement: .60 in the first test and .75 in the second. Results showed that two of four pigeons chose the trial with a hint significantly more often before receiving a novel list than the familiar list in the four sessions of the first test, and three did so in the second test. Impressively, one bird showed robust evidence in the very first sessions in both tests. These results suggest that pigeons may monitor their long-term knowledge states and thereby control their environment before starting to solve a task.

Theory of mind in a first-episode psychosis population using the Hinting Task.

PubMed

Lindgren, Maija; Torniainen-Holm, Minna; Heiskanen, Inkeri; Voutilainen, Greta; Pulkkinen, Ulla; Mehtälä, Tuukka; Jokela, Markus; Kieseppä, Tuula; Suvisaari, Jaana; Therman, Sebastian

2018-05-01

Deficiencies in theory of mind (ToM) are common in psychosis and may largely explain impaired social functioning. Currently, it is unclear whether impairments in ToM are explained by the more general cognitive deficits related to psychosis or whether ToM is impaired in psychosis independently of other cognitive deficits. This study examined ToM using the Hinting Task in young adults (n = 66) with first-episode psychosis and matched controls (n = 62). The participants were administered a broad neuropsychological assessment. Participants with psychosis performed worse than controls on the Hinting Task. However, 75% of the variance between the groups was explained by general cognitive deficits, especially impaired processing speed and episodic memory. Hinting Task performance of the best functioning patient group did not differ from that of the control group. When the psychosis group was divided according to diagnosis, the Hinting Task difference between individuals with schizophrenia and controls remained significant even when general cognitive performance was controlled for, suggesting specific verbal ToM deficits in schizophrenia. In contrast, those with other psychotic disorders did not differ from controls. Our results suggest that ToM deficits can be seen in early phases of psychotic disorders, schizophrenia in particular, and are partly independent of other cognitive functions. Copyright © 2018 Elsevier B.V. All rights reserved.

Modeling Large-Scale Networks Using Virtual Machines and Physical Appliances

DTIC Science & Technology

2014-01-27

downloaded and run locally. The lab solution couldn’t be based on ActiveX because the military Report Documentation Page Form ApprovedOMB No. 0704-0188...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 disallowed ActiveX support on...its systems, which made running an RDP client over ActiveX not possible. The challenges the SEI encountered in delivering the instruction were

Terahertz MMICs and Antenna-in-Package Technology at 300 GHz for KIOSK Download System

NASA Astrophysics Data System (ADS)

Tajima, Takuro; Kosugi, Toshihiko; Song, Ho-Jin; Hamada, Hiroshi; El Moutaouakil, Amine; Sugiyama, Hiroki; Matsuzaki, Hideaki; Yaita, Makoto; Kagami, Osamu

2016-12-01

Toward the realization of ultra-fast wireless communications systems, the inherent broad bandwidth of the terahertz (THz) band is attracting attention, especially for short-range instant download applications. In this paper, we present our recent progress on InP-based THz MMICs and packaging techniques based on low-temperature co-fibered ceramic (LTCC) technology. The transmitter MMICs are based on 80-nm InP-based high electron mobility transistors (HEMTs). Using the transmitter packaged in an E-plane split-block waveguide and compact lens receiver packaged in LTCC multilayered substrates, we tested wireless data transmission up to 27 Gbps with the simple amplitude key shifting (ASK) modulation scheme. We also present several THz antenna-in-packaging solutions based on substrate integrated waveguide (SIW) technology. A vertical hollow (VH) SIW was applied to a compact medium-gain SIW antenna and low-loss interconnection integrated in LTCC multi-layer substrates. The size of the LTCC antennas with 15-dBi gain is less than 0.1 cm3. For feeding the antenna, we investigated an LTCC-integrated transition and polyimide transition to LTCC VH SIWs. These transitions exhibit around 1-dB estimated loss at 300 GHz and more than 35 GHz bandwidth with 10-dB return loss. The proposed package solutions make antennas and interconnections easy to integrate in a compact LTCC package with an MMIC chip for practical applications.

Helpful Hints for School Emergency Management: Emergency "Go-Kits"

ERIC Educational Resources Information Center

Hill, Tara

2006-01-01

"Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. The Office of Safe and Drug-Free Schools (OSDFS) encourages schools to consider emergency management in the context of its four phases: mitigation and prevention, preparedness, response, and recovery. The preparedness phase…

From a Parent's Perspective: Hints for Morning Success.

ERIC Educational Resources Information Center

Duffy, Roslyn

1996-01-01

Recommends the development of a routine to transform the morning getting-ready battleground into a congenial team effort. Offers hints for a successful routine, including expecting everyone to be dressed before breakfast; considering having no TV; eliminating most morning decision-making; involving everyone; and not using rewards with routines.…

Hints on storing timber to prevent decay

Treesearch

Forest Products Laboratory

1919-01-01

Many serious losses from decay in wooden structures are due to the fact that the timbers used were infected with wood-destroying fungi while in storage. These losses can be greatly reduced by keeping lumber storage yards in a sanitary condition. Some hints as to how to do this are given below.

Unsupervised MDP Value Selection for Automating ITS Capabilities

ERIC Educational Resources Information Center

Stamper, John; Barnes, Tiffany

2009-01-01

We seek to simplify the creation of intelligent tutors by using student data acquired from standard computer aided instruction (CAI) in conjunction with educational data mining methods to automatically generate adaptive hints. In our previous work, we have automatically generated hints for logic tutoring by constructing a Markov Decision Process…

Images

Science.gov Websites

: Upload Date Photo Date 1 2 3 4 5 Next Arctic Edge 2018 Download Full Image Photo Details Arctic Edge 2018 Download Full Image Photo Details Arctic Edge 2018 Download Full Image Photo Details Arctic Edge 2018 Download Full Image Photo Details Arctic Edge 2018 Download Full Image Photo Details Arctic Edge 2018

How do I obtain CERES data?

Atmospheric Science Data Center

2017-10-12

Order online ASDC Web Ordering Tool data available for ftp download. Order online CERES Subsetter Ordering Page data available for ftp download. Order online Earthdata Search Tool data available for download. Download the ...

Updating and Maintaining School Emergency Management Plans. Helpful Hints for School Emergency Management. Volume 2, Issue 3, 2007

ERIC Educational Resources Information Center

US Department of Education, 2007

2007-01-01

"Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. Developing and implementing comprehensive, multi-hazard emergency management plans is an ongoing process that must be consistently reinforced and strengthened. Opportunities for reviewing, strengthening and updating…

Web-Based Quiz-Game-Like Formative Assessment: Development and Evaluation

ERIC Educational Resources Information Center

Wang, Tzu-Hua

2008-01-01

This research aims to develop a multiple-choice Web-based quiz-game-like formative assessment system, named GAM-WATA. The unique design of "Ask-Hint Strategy" turns the Web-based formative assessment into an online quiz game. "Ask-Hint Strategy" is composed of "Prune Strategy" and "Call-in Strategy".…

Art Experiences for Young Children.

ERIC Educational Resources Information Center

Pile, Naomi F.

This book points out methods and materials that can be used by teachers helping preschoolers express their ideas and emotions through art. Hints on how to create atmosphere conducive to artwork and how to increase children's awareness of the visual world are given, along with hints on buying, using, and storing materials. Specific instructions are…

Shared Challenges in Object Perception for Robots and Infants

ERIC Educational Resources Information Center

Fitzpatrick, Paul; Needham, Amy; Natale, Lorenzo; Metta, Giorgio

2008-01-01

Robots and humans receive partial, fragmentary hints about the world's state through their respective sensors. These hints--tiny patches of light intensity, frequency components of sound, etc.--are far removed from the world of objects which we feel and perceive so effortlessly around us. The study of infant development and the construction of…

A case of neuromyotonia and axonal motor neuropathy: A report of a HINT1 mutation in the United States.

PubMed

Jerath, Nivedita U; Shy, Michael E; Grider, Tiffany; Gutmann, Ludwig

2015-12-01

HINT1 mutations cause an autosomal recessive distal hereditary motor axonal neuropathy with neuromyotonia. This is a case report of a HINT1 mutation in the United States. A 30-year-old man of Slovenian heritage and no significant family history presented with scoliosis as a child and later developed neuromyotonia and distal weakness. Electrodiagnostic testing revealed an axonal motor neuropathy and neuromyotonic discharges. Previous diagnostic work-up, including testing for Cx32, MPZ, PMP-22, NF-L, EGR2, CLCN1, DM1, DM2, SMN exon 7/8, emerin, LMNA, MPK, SCNA4, acid maltase gene, paraneoplastic disorder, and a sural nerve biopsy, was negative. Genetic testing for a HINT1 mutation was performed and revealed a homozygous mutation at p.Arg37Pro. This entity should be distinguished clinically and genetically from myotonic dystrophy and channelopathies with the clinical features of neuromyotonia and an axonal neuropathy. This case illustrates the importance of identifying the correct phenotype to avoid unnecessary and costly evaluations. © 2015 Wiley Periodicals, Inc.

Comparative predictive validity of the Harris Infant Neuromotor Test and the Alberta Infant Motor Scale.

PubMed

Harris, Susan R; Backman, Catherine L; Mayson, Tanja A

2010-05-01

We compared abilities of the Alberta Infant Motor Scale (AIMS) and the Harris Infant Neuromotor Test (HINT), during the infant's first year, in predicting scores on the Bayley Scales of Infant Development (BSID) at age 2 and 3 years. This prospective study involved 144 infants (71 females, 73 males), assessed with the HINT and AIMS at 4 to 6.5 and 10 to 12.5 months and with the BSID at 2 and 3 years. Inclusion criteria for typical infants (n=58) were the following: 38 to 42 weeks' gestation, birthweight at least 2500g, and no congenital anomaly, postnatal health concern, nor major prenatal or perinatal maternal risk factor. For at-risk infants (n=86), inclusion criteria were any of the following: less than 38 weeks' gestation, birthweight less than 2500g, maternal age older than 35 years or younger than 19 years at infant birth, maternal psychiatric/mental health concerns, prenatal drug/alcohol exposure, multiple births, or use of reproductive technology. For the overall sample, the early (4-6.5mo) HINT had higher predictive correlations than the AIMS for 2-year BSID-II motor outcomes (r=-0.36 vs 0.26), and 3-year BSID-III gross motor outcomes (r=-0.45 vs 0.31), as did the 10- to 12.5-month HINT (r=-0.55 vs 0.47). Correlations were identical for 10- to 12.5-month HINT and AIMS scores and 3-year BSID-III gross motor (r=-0.58 and 0.58) and fine motor (r=-0.35 and 0.35) subscales. When the sample was divided into typical and at-risk groups, predictive correlations were consistently stronger for the at-risk infants. Categorical predictive analyses were reasonably similar across both tests. Results suggest that the HINT has comparable predictive validity to the AIMS and should be considered for use in clinical and research settings.

A Java software for creation of image mosaics.

PubMed

Bossert, Oliver

2004-08-01

Besides the dimensions of the selected image field width, the resolution of the individual objects is also of major importance for automatic reconstruction and other sophisticated histological work. The software solution presented here allows the user to create image mosaics by using a combination of several photographs. Optimum control is achieved by combining two procedures and several control mechanisms. In sample tests involving 50 image pairs, all images were mosaiced without giving rise to error. The program is ready for public download.

Share, steal, or buy? A social cognitive perspective of music downloading.

PubMed

LaRose, Robert; Kim, Junghyun

2007-04-01

The music downloading phenomenon presents a unique opportunity to examine normative influences on media consumption behavior. Downloaders face moral, legal, and ethical quandaries that can be conceptualized as normative influences within the self-regulatory mechanism of social cognitive theory. The music industry hopes to eliminate illegal file sharing and to divert illegal downloaders to pay services by asserting normative influence through selective prosecutions and public information campaigns. However the deficient self-regulation of downloaders counters these efforts maintaining file sharing as a persistent habit that defies attempts to establish normative control. The present research tests and extends the social cognitive theory of downloading on a sample of college students. The expected outcomes of downloading behavior and deficient self-regulation of that behavior were found to be important determinants of intentions to continue downloading. Consistent with social cognitive theory but in contrast to the theory of planned behavior, it was found that descriptive and prescriptive norms influenced deficient self-regulation but had no direct impact on behavioral intentions. Downloading intentions also had no direct relationship to either compact disc purchases or to subscription to online pay music services.

Diphotons, new vacuum angles, and strong CP

DOE PAGES

Draper, Patrick; McKeen, David

2016-04-20

The Standard Model contains a well-understood, natural, spin-0 diphoton resonance: the π 0. Numerous studies have pointed out that the hint of a new diphoton resonance at 750 GeV could be a pion analog, identified with the pseudo-Nambu-Goldstone boson of a chiral symmetry spontaneously broken by new strong dynamics at the TeV scale. These “hypercolor” models are generically expected to violate parity through a topological angle θ ~. We discuss the physics of θ ~ and its impact on the phenomenology of the new sector. We also describe some of the theoretical implications of a nonzero θ ~. In particular,more » θ ~ can generate an O(1) threshold correction to the QCD vacuum angle θ near the TeV scale, sharply constraining ultraviolet solutions to the strong CP problem. Furthermore, finding that θ ~ is small may be interpreted as evidence in favor of UV solutions to strong CP, particularly those based on spontaneously broken P or CP symmetries.« less

Water/ice phase transition: The role of zirconium acetate, a compound with ice-shaping properties

NASA Astrophysics Data System (ADS)

Marcellini, Moreno; Fernandes, Francisco M.; Dedovets, Dmytro; Deville, Sylvain

2017-04-01

Few compounds feature ice-shaping properties. Zirconium acetate is one of the very few inorganic compounds reported so far to have ice-shaping properties similar to that of ice-shaping proteins, encountered in many organisms living at low temperature. When a zirconium acetate solution is frozen, oriented and perfectly hexagonal ice crystals can be formed and their growth follows the temperature gradient. To shed light on the water/ice phase transition while freezing zirconium acetate solution, we carried out differential scanning calorimetry measurements. From our results, we estimate how many water molecules do not freeze because of their interaction with Zr cations. We estimate the colligative properties of the Zr acetate on the apparent critical temperature. We further show that the phase transition is unaffected by the nature of the base which is used to adjust the pH. Our results provide thus new hints on the ice-shaping mechanism of zirconium acetate.

Diphotons, new vacuum angles, and strong CP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Draper, Patrick; McKeen, David

The Standard Model contains a well-understood, natural, spin-0 diphoton resonance: the π 0. Numerous studies have pointed out that the hint of a new diphoton resonance at 750 GeV could be a pion analog, identified with the pseudo-Nambu-Goldstone boson of a chiral symmetry spontaneously broken by new strong dynamics at the TeV scale. These “hypercolor” models are generically expected to violate parity through a topological angle θ ~. We discuss the physics of θ ~ and its impact on the phenomenology of the new sector. We also describe some of the theoretical implications of a nonzero θ ~. In particular,more » θ ~ can generate an O(1) threshold correction to the QCD vacuum angle θ near the TeV scale, sharply constraining ultraviolet solutions to the strong CP problem. Furthermore, finding that θ ~ is small may be interpreted as evidence in favor of UV solutions to strong CP, particularly those based on spontaneously broken P or CP symmetries.« less

Market Innovation, Rational Housing Supply and Urban Quality at the Neighbourhood Scale

NASA Astrophysics Data System (ADS)

Puglisi, Valentina; Celani, Alberto

2017-10-01

Innovation of product, process and markets are the three categories to assess the improvement of a sector. This document is aimed to provide a review of papers about innovation in housing market and analyses solutions adopted by the international market in terms of definition of attributes of housing products. Enlightening aspects linked to quality attributes of housing products and it has been tried to read a common scheme in any study analysed to provide solutions to set innovation hints to enhance market innovation in the sector. The idea of choice, user and buyer categories definition, assessment and rating system is the backbone of the paper, as the parallelism between marketing of industrial goods and services and built environment objects. Quality of the neighbourhood and the idea of an ex-post assessment is the theme behind the last case presented, based on a research made by ABC Department of Politecnico di Milano in a neighbourhood in Milano, aimed to assess its quality.

Water/ice phase transition: The role of zirconium acetate, a compound with ice-shaping properties.

PubMed

Marcellini, Moreno; Fernandes, Francisco M; Dedovets, Dmytro; Deville, Sylvain

2017-04-14

Few compounds feature ice-shaping properties. Zirconium acetate is one of the very few inorganic compounds reported so far to have ice-shaping properties similar to that of ice-shaping proteins, encountered in many organisms living at low temperature. When a zirconium acetate solution is frozen, oriented and perfectly hexagonal ice crystals can be formed and their growth follows the temperature gradient. To shed light on the water/ice phase transition while freezing zirconium acetate solution, we carried out differential scanning calorimetry measurements. From our results, we estimate how many water molecules do not freeze because of their interaction with Zr cations. We estimate the colligative properties of the Zr acetate on the apparent critical temperature. We further show that the phase transition is unaffected by the nature of the base which is used to adjust the pH. Our results provide thus new hints on the ice-shaping mechanism of zirconium acetate.

Interaction Networks: Generating High Level Hints Based on Network Community Clustering

ERIC Educational Resources Information Center

Eagle, Michael; Johnson, Matthew; Barnes, Tiffany

2012-01-01

We introduce a novel data structure, the Interaction Network, for representing interaction-data from open problem solving environment tutors. We show how using network community detecting techniques are used to identify sub-goals in problems in a logic tutor. We then use those community structures to generate high level hints between sub-goals.…

Helpful Hints for School Emergency Management: Steps for Developing a School Emergency Management Plan

ERIC Educational Resources Information Center

US Department of Education, 2007

2007-01-01

"Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. The U.S. Department of Education's Office of Safe and Drug-Free Schools strongly encourages schools and school districts to develop emergency management plans within the context of the four phases of emergency management:…

Examining Tasks that Facilitate the Experience of Incubation While Problem-Solving

ERIC Educational Resources Information Center

Both, Lilly; Needham, Douglas; Wood, Eileen

2004-01-01

The three studies presented here contrasted the problem-solving outcomes of university students when a break was provided or not provided during a problem-solving session. In addition, two studies explored the effect of providing hints (priming) and the placement of hints during the problem-solving session. First, the ability to solve a previously…

What Does the Public Know about Preventing Cancer? Results from the Health Information National Trends Survey (HINTS)

ERIC Educational Resources Information Center

Hawkins, Nikki A.; Berkowitz, Zahava; Peipins, Lucy A.

2010-01-01

This study provides information about the public's familiarity with cancer prevention strategies and examines the association between this familiarity and actual prevention behavior. Data from interviews with 5,589 adults included in the 2003 Health Information National Trends Survey (HINTS) were analyzed. Most respondents were able to cite one or…

Semantic Elaboration through Integration: Hints Both Facilitate and Inform the Process

ERIC Educational Resources Information Center

Bauer, Patricia J.; Varga, Nicole L.; King, Jessica E.; Nolen, Ayla M.; White, Elizabeth A.

2015-01-01

Semantic knowledge can be extended in a variety of ways, including self-generation of new facts through integration of separate yet related episodes. We sought to promote integration and self-generation by providing "hints" to help 6-year-olds (Experiment 1) and 4-year-olds (Experiment 2) see the relevance of separate episodes to one…

Pedagogical Agent Gestures to Improve Learner Comprehension of Abstract Concepts in Hints

ERIC Educational Resources Information Center

Martins, Igor; de Morais, Felipe; Schaab, Bruno; Jaques, Patricia

2016-01-01

In most Intelligent Tutoring Systems, the help messages (hints) are not very clear for students as they are only presented textually and have little connection with the task elements. This can lead to students' undesired behaviors, like gaming the system, associated with low performance. In this paper, the authors aim at evaluating if the gestures…

Light weakly interacting massive particles

NASA Astrophysics Data System (ADS)

Gelmini, Graciela B.

2017-08-01

Light weakly interacting massive particles (WIMPs) are dark matter particle candidates with weak scale interaction with the known particles, and mass in the GeV to tens of GeV range. Hints of light WIMPs have appeared in several dark matter searches in the last decade. The unprecedented possible coincidence into tantalizingly close regions of mass and cross section of four separate direct detection experimental hints and a potential indirect detection signal in gamma rays from the galactic center, aroused considerable interest in our field. Even if these hints did not so far result in a discovery, they have had a significant impact in our field. Here we review the evidence for and against light WIMPs as dark matter candidates and discuss future relevant experiments and observations.

The most downloaded and most cited articles in radiology journals: a comparative bibliometric analysis.

PubMed

Baek, Sora; Yoon, Dae Young; Lim, Kyoung Ja; Cho, Young Kwon; Seo, Young Lan; Yun, Eun Joo

2018-05-07

To evaluate and compare the characteristics of the most downloaded and most cited articles in radiology journals. We selected 41 radiology journals that provided lists of both the most downloaded and most cited articles on their websites, and identified the 596 most downloaded articles and 596 most cited articles. We compared the following characteristics of the most downloaded and most cited articles: year of publication, journal title, department of the first author, country of origin, publication type, radiologic subspecialty, radiologic technique and accessibility. Compared to the most cited articles, the most downloaded articles were more frequently review articles (36.1% vs 17.1%, p < 0.05), case reports (5.9% vs 3.2%, p < 0.05), guidelines/consensus statements (5.4% vs 2.7%, p < 0.05), editorials/commentaries (3.7% vs 0.7%, p < 0.05) and pictorial essays (2.0% vs 0.2%, p < 0.05). Compared to the most cited articles, the most downloaded articles more frequently originated from the UK (8.7% vs 5.0%, p < 0.05) and were more frequently free-access articles (46.0% vs 39.4%, p < 0.05). Educational and free-access articles are more frequent among the most downloaded articles. • There was only small overlap between the most downloaded and most cited articles. • Educational articles were more frequent among the most downloaded articles. • Free-access articles are more frequent among the most downloaded articles.

The cyber-aspects of virtual communities: free downloader ethics, cognition, and perceived service quality.

PubMed

Lin, Chin-Feng

2008-02-01

This study examined the downloader cognitive structures toward Web service quality and the downloader ethical attitudes across various levels of participation in a virtual community. Using four types of free downloads as the research subjects, the researcher found that the users in different participation degrees have different perception preferences. Owners of the free downloading Web sites can use the findings of this study to develop effective Web marketing strategies.

Role of matter in extended quasidilaton massive gravity

NASA Astrophysics Data System (ADS)

Gümrükçüoǧlu, A. Emir; Koyama, Kazuya; Mukohyama, Shinji

2016-12-01

The extended quasidilaton theory is one of the simplest Lorentz-invariant massive gravity theories which can accommodate a stable self-accelerating vacuum solution. In this paper we revisit this theory and study the effect of matter fields. For a matter sector that couples minimally to the physical metric, we find hints of a Jeans type instability in the IR. In the analogue k-essence field setup, this instability manifests itself as an IR ghost for the scalar field perturbation, but this can be interpreted as a classical instability that becomes relevant below some momentum scale in terms of matter density perturbations. We also consider the effect of the background evolution influenced by matter on the stability of the gravity sector perturbations. In particular, we address the previous claims of ghost instability in the IR around the late time attractor. We show that, although the matter-induced modification of the evolution potentially brings tension to the stability conditions, one goes beyond the regime of validity of the effective theory well before the solutions become unstable. We also draw attention to the fact that the IR stability conditions are also enforced by the existence requirements of consistent background solutions.

Dissipative behavior of some fully non-linear KdV-type equations

NASA Astrophysics Data System (ADS)

Brenier, Yann; Levy, Doron

2000-03-01

The KdV equation can be considered as a special case of the general equation u t+f(u) x-δg(u xx) x=0, δ>0, where f is non-linear and g is linear, namely f( u)= u2/2 and g( v)= v. As the parameter δ tends to 0, the dispersive behavior of the KdV equation has been throughly investigated (see, e.g., [P.G. Drazin, Solitons, London Math. Soc. Lect. Note Ser. 85, Cambridge University Press, Cambridge, 1983; P.D. Lax, C.D. Levermore, The small dispersion limit of the Korteweg-de Vries equation, III, Commun. Pure Appl. Math. 36 (1983) 809-829; G.B. Whitham, Linear and Nonlinear Waves, Wiley/Interscience, New York, 1974] and the references therein). We show through numerical evidence that a completely different, dissipative behavior occurs when g is non-linear, namely when g is an even concave function such as g( v)=-∣ v∣ or g( v)=- v2. In particular, our numerical results hint that as δ→0 the solutions strongly converge to the unique entropy solution of the formal limit equation, in total contrast with the solutions of the KdV equation.

Facilitating students' application of the integral and the area under the curve concepts in physics problems

NASA Astrophysics Data System (ADS)

Nguyen, Dong-Hai

This research project investigates the difficulties students encounter when solving physics problems involving the integral and the area under the curve concepts and the strategies to facilitate students learning to solve those types of problems. The research contexts of this project are calculus-based physics courses covering mechanics and electromagnetism. In phase I of the project, individual teaching/learning interviews were conducted with 20 students in mechanics and 15 students from the same cohort in electromagnetism. The students were asked to solve problems on several topics of mechanics and electromagnetism. These problems involved calculating physical quantities (e.g. velocity, acceleration, work, electric field, electric resistance, electric current) by integrating or finding the area under the curve of functions of related quantities (e.g. position, velocity, force, charge density, resistivity, current density). Verbal hints were provided when students made an error or were unable to proceed. A total number of 140 one-hour interviews were conducted in this phase, which provided insights into students' difficulties when solving the problems involving the integral and the area under the curve concepts and the hints to help students overcome those difficulties. In phase II of the project, tutorials were created to facilitate students' learning to solve physics problems involving the integral and the area under the curve concepts. Each tutorial consisted of a set of exercises and a protocol that incorporated the helpful hints to target the difficulties that students expressed in phase I of the project. Focus group learning interviews were conducted to test the effectiveness of the tutorials in comparison with standard learning materials (i.e. textbook problems and solutions). Overall results indicated that students learning with our tutorials outperformed students learning with standard materials in applying the integral and the area under the curve concepts to physics problems. The results of this project provide broader and deeper insights into students' problem solving with the integral and the area under the curve concepts and suggest strategies to facilitate students' learning to apply these concepts to physics problems. This study also has significant implications for further research, curriculum development and instruction.

The intracellular domain of teneurin-1 induces the activity of microphthalmia-associated transcription factor (MITF) by binding to transcriptional repressor HINT1.

PubMed

Schöler, Jonas; Ferralli, Jacqueline; Thiry, Stéphane; Chiquet-Ehrismann, Ruth

2015-03-27

Teneurins are large type II transmembrane proteins that are necessary for the normal development of the CNS. Although many studies highlight the significance of teneurins, especially during development, there is only limited information known about the molecular mechanisms of function. Previous studies have shown that the N-terminal intracellular domain (ICD) of teneurins can be cleaved at the membrane and subsequently translocates to the nucleus, where it can influence gene transcription. Because teneurin ICDs do not contain any intrinsic DNA binding sequences, interaction partners are required to affect transcription. Here, we identified histidine triad nucleotide binding protein 1 (HINT1) as a human teneurin-1 ICD interaction partner in a yeast two-hybrid screen. This interaction was confirmed in human cells, where HINT1 is known to inhibit the transcription of target genes by directly binding to transcription factors at the promoter. In a whole transcriptome analysis of BS149 glioblastoma cells overexpressing the teneurin-1 ICD, several microphthalmia-associated transcription factor (MITF) target genes were found to be up-regulated. Directly comparing the transcriptomes of MITF versus TEN1-ICD-overexpressing BS149 cells revealed 42 co-regulated genes, including glycoprotein non-metastatic b (GPNMB). Using real-time quantitative PCR to detect endogenous GPNMB expression upon overexpression of MITF and HINT1 as well as promoter reporter assays using GPNMB promoter constructs, we could demonstrate that the teneurin-1 ICD binds HINT1, thus switching on MITF-dependent transcription of GPNMB. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

JHelioviewer: Open-Source Software for Discovery and Image Access in the Petabyte Age (Invited)

NASA Astrophysics Data System (ADS)

Mueller, D.; Dimitoglou, G.; Langenberg, M.; Pagel, S.; Dau, A.; Nuhn, M.; Garcia Ortiz, J. P.; Dietert, H.; Schmidt, L.; Hughitt, V. K.; Ireland, J.; Fleck, B.

2010-12-01

The unprecedented torrent of data returned by the Solar Dynamics Observatory is both a blessing and a barrier: a blessing for making available data with significantly higher spatial and temporal resolution, but a barrier for scientists to access, browse and analyze them. With such staggering data volume, the data is bound to be accessible only from a few repositories and users will have to deal with data sets effectively immobile and practically difficult to download. From a scientist's perspective this poses three challenges: accessing, browsing and finding interesting data while avoiding the proverbial search for a needle in a haystack. To address these challenges, we have developed JHelioviewer, an open-source visualization software that lets users browse large data volumes both as still images and movies. We did so by deploying an efficient image encoding, storage, and dissemination solution using the JPEG 2000 standard. This solution enables users to access remote images at different resolution levels as a single data stream. Users can view, manipulate, pan, zoom, and overlay JPEG 2000 compressed data quickly, without severe network bandwidth penalties. Besides viewing data, the browser provides third-party metadata and event catalog integration to quickly locate data of interest, as well as an interface to the Virtual Solar Observatory to download science-quality data. As part of the Helioviewer Project, JHelioviewer offers intuitive ways to browse large amounts of heterogeneous data remotely and provides an extensible and customizable open-source platform for the scientific community.

Adult Participation in Children's Word Searches: On the Use of Prompting, Hinting, and Supplying a Model

ERIC Educational Resources Information Center

Radford, Julie

2010-01-01

Although word searching in children is very common, very little is known about how adults support children in the turns following the child's search behaviours, an important topic because of the social, educational, and clinical implications. This study characterizes, in detail, teachers' use of prompting, hinting, and supplying a model. From a…

How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the αβ-Tubulin Colchicine Site

PubMed Central

Da, Chenxiao; Mooberry, Susan L.; Gupton, John T.; Kellogg, Glen E.

2013-01-01

αβ-tubulin colchicine site inhibitors (CSIs) from four scaffolds that we previously tested for antiproliferative activity were modeled to better understand their effect on microtubules. Docking models, constructed by exploiting the SAR of a pyrrole subset and HINT scoring, guided ensemble docking of all 59 compounds. This conformation set and two variants having progressively less structure knowledge were subjected to CoMFA, CoMFA+HINT, and CoMSIA 3D-QSAR analyses. The CoMFA+HINT model (docked alignment) showed the best statistics: leave-one-out q2 of 0.616, r2 of 0.949 and r2pred (internal test set) of 0.755. An external (tested in other laboratories) collection of 24 CSIs from eight scaffolds were evaluated with the 3D-QSAR models, which correctly ranked their activity trends in 7/8 scaffolds for CoMFA+HINT (8/8 for CoMFA). The combination of SAR, ensemble docking, hydropathic analysis and 3D-QSAR provides an atomic-scale colchicine site model more consistent with a target structure resolution much higher than the ~3.6 Å available for αβ-tubulin. PMID:23961916

Very empirical treatment of solvation and entropy: a force field derived from Log Po/w

NASA Astrophysics Data System (ADS)

Kellogg, Glen Eugene; Burnett, James C.; Abraham, Donald J.

2001-04-01

A non-covalent interaction force field model derived from the partition coefficient of 1-octanol/water solubility is described. This model, HINT for Hydropathic INTeractions, is shown to include, in very empirical and approximate terms, all components of biomolecular associations, including hydrogen bonding, Coulombic interactions, hydrophobic interactions, entropy and solvation/desolvation. Particular emphasis is placed on: (1) demonstrating the relationship between the total empirical HINT score and free energy of association, ΔG interaction; (2) showing that the HINT hydrophobic-polar interaction sub-score represents the energy cost of desolvation upon binding for interacting biomolecules; and (3) a new methodology for treating constrained water molecules as discrete independent small ligands. An example calculation is reported for dihydrofolate reductase (DHFR) bound with methotrexate (MTX). In that case the observed very tight binding, ΔG interaction≤-13.6 kcal mol-1, is largely due to ten hydrogen bonds between the ligand and enzyme with estimated strength ranging between -0.4 and -2.3 kcal mol-1. Four water molecules bridging between DHFR and MTX contribute an additional -1.7 kcal mol-1 stability to the complex. The HINT estimate of the cost of desolvation is +13.9 kcal mol-1.

Chain of Custody Item Monitor Message Viewer v.1.0 Beta

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwartz, Steven Robert; Fielder, Laura; Hymel, Ross W.

The CoCIM Message Viewer software allows users to connect to and download messages from a Chain of Custody Item Monitor (CoCIM) connected to a serial port on the user’s computer. The downloaded messages are authenticated and displayed in a Graphical User Interface that allows the user a limited degree of sorting and filtering of the downloaded messages as well as the ability to save downloaded files or to open previously downloaded message history files.

Neuroimaging, Genetics, and Clinical Data Sharing in Python Using the CubicWeb Framework

PubMed Central

Grigis, Antoine; Goyard, David; Cherbonnier, Robin; Gareau, Thomas; Papadopoulos Orfanos, Dimitri; Chauvat, Nicolas; Di Mascio, Adrien; Schumann, Gunter; Spooren, Will; Murphy, Declan; Frouin, Vincent

2017-01-01

In neurosciences or psychiatry, the emergence of large multi-center population imaging studies raises numerous technological challenges. From distributed data collection, across different institutions and countries, to final data publication service, one must handle the massive, heterogeneous, and complex data from genetics, imaging, demographics, or clinical scores. These data must be both efficiently obtained and downloadable. We present a Python solution, based on the CubicWeb open-source semantic framework, aimed at building population imaging study repositories. In addition, we focus on the tools developed around this framework to overcome the challenges associated with data sharing and collaborative requirements. We describe a set of three highly adaptive web services that transform the CubicWeb framework into a (1) multi-center upload platform, (2) collaborative quality assessment platform, and (3) publication platform endowed with massive-download capabilities. Two major European projects, IMAGEN and EU-AIMS, are currently supported by the described framework. We also present a Python package that enables end users to remotely query neuroimaging, genetics, and clinical data from scripts. PMID:28360851

A mobile-phone immunization record in Ontario: uptake and opportunities for improving public health.

PubMed

Wilson, Kumanan; Atkinson, Katherine; Pluscauskas, Michael; Bell, Cameron

2014-12-01

A free iPhone app was designed to help parents in Ontario track their children's vaccination records. It was launched in the iTunes app store on 20 November 2012. There were 4867 downloads in the following 12 months. We observed that downloads of the app were correlated with media coverage. Usage of the app was measured by app opens and the time spent in the app per open: on average there were 53 opens per day and 126 seconds spent per open. Users expressed concerns about the privacy of health information and accessibility by people of lower socioeconomic status, who were less likely to be smartphone owners. A national version of the app is now being developed for multiple mobile phone types. There is potential to develop additional features such as mobile adverse event reporting, vaccine vial barcode scanning and integration with immunization registries. Immunization is an area in which a mobile solution is very useful. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Neuroimaging, Genetics, and Clinical Data Sharing in Python Using the CubicWeb Framework.

PubMed

Grigis, Antoine; Goyard, David; Cherbonnier, Robin; Gareau, Thomas; Papadopoulos Orfanos, Dimitri; Chauvat, Nicolas; Di Mascio, Adrien; Schumann, Gunter; Spooren, Will; Murphy, Declan; Frouin, Vincent

2017-01-01

In neurosciences or psychiatry, the emergence of large multi-center population imaging studies raises numerous technological challenges. From distributed data collection, across different institutions and countries, to final data publication service, one must handle the massive, heterogeneous, and complex data from genetics, imaging, demographics, or clinical scores. These data must be both efficiently obtained and downloadable. We present a Python solution, based on the CubicWeb open-source semantic framework, aimed at building population imaging study repositories. In addition, we focus on the tools developed around this framework to overcome the challenges associated with data sharing and collaborative requirements. We describe a set of three highly adaptive web services that transform the CubicWeb framework into a (1) multi-center upload platform, (2) collaborative quality assessment platform, and (3) publication platform endowed with massive-download capabilities. Two major European projects, IMAGEN and EU-AIMS, are currently supported by the described framework. We also present a Python package that enables end users to remotely query neuroimaging, genetics, and clinical data from scripts.

The Effect of Incidental Hints when Problems Are Suspended before, during, or after an Impasse

ERIC Educational Resources Information Center

Moss, Jarrod; Kotovsky, Kenneth; Cagan, Jonathan

2011-01-01

Two studies examine how the time at which problem solving is suspended relative to an impasse affects the impact of incidental hints. An impasse is a point in problem solving at which a problem solver is not making progress and does not know how to proceed. In both studies, work on remote associates problems was suspended before an impasse was…

Components of Comprehensive School and School District Emergency Management Plans. Helpful Hints for School Emergency Management. Volume 2, Issue 2, 2007

ERIC Educational Resources Information Center

US Department of Education, 2007

2007-01-01

"Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. This issue describes and contains a checklist that can assist schools and school districts in developing a new emergency management plan or refreshing their current one. To use the checklist, individuals should consider…

Helpful Hints for School Emergency Management: The National Incident Management System (NIMS) and Schools. Frequently Asked Questions and FY 2006 NIMS Compliance Activities for Schools

ERIC Educational Resources Information Center

US Department of Education, 2006

2006-01-01

"Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. The National Incident Management System (NIMS) is a comprehensive system that improves tribal and local emergency response operations through the use of the Incident Command System (ICS) and the application of standardized…

CARGO: effective format-free compressed storage of genomic information

PubMed Central

Roguski, Łukasz; Ribeca, Paolo

2016-01-01

The recent super-exponential growth in the amount of sequencing data generated worldwide has put techniques for compressed storage into the focus. Most available solutions, however, are strictly tied to specific bioinformatics formats, sometimes inheriting from them suboptimal design choices; this hinders flexible and effective data sharing. Here, we present CARGO (Compressed ARchiving for GenOmics), a high-level framework to automatically generate software systems optimized for the compressed storage of arbitrary types of large genomic data collections. Straightforward applications of our approach to FASTQ and SAM archives require a few lines of code, produce solutions that match and sometimes outperform specialized format-tailored compressors and scale well to multi-TB datasets. All CARGO software components can be freely downloaded for academic and non-commercial use from http://bio-cargo.sourceforge.net. PMID:27131376

Airloads on Bluff Bodies, with Application to the Rotor-Induced Downloads on Tilt-Rotor Aircraft.

DTIC Science & Technology

1983-09-01

interference aerodynamics would be tion on hover performance (Ref. (11). to study the two-dimensional sec- tion characteristics of a wing in the wake of a...resources for large numbers of vortices; a typical case requires 10-15 min CPU time on the Ames Cray IS computer. Figure 6 shows a typical result. Here...CPU time per case on a Prime 550UPPER SURFACE (WINDWARD) computer to converge to a steady solution; this would be equivalent to one or two seconds on

Pipettor Version 5.x

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thorn, David L.

Code is written in Basic to run using web-available Basic assembler, available at justbasic.com. It drives a set of stepper motors to mechanize the operation of pipetting radioactive solutions within a hot cell, and it communicates via serial port with the C4 stepper controller sold by Arrick, see http://www.arrickrobotics.com/c4md2.html. It is intended to operate stand-alone, that is, the justbasic assembler/application is downloaded onto a PC, the application runs the software program Pipettor, and the instructions are included as comments within the software.

Determination of the Potential Benefit of Time-Frequency Gain Manipulation

PubMed Central

Anzalone, Michael C.; Calandruccio, Lauren; Doherty, Karen A.; Carney, Laurel H.

2008-01-01

Objective The purpose of this study was to determine the maximum benefit provided by a time-frequency gain-manipulation algorithm for noise-reduction (NR) based on an ideal detector of speech energy. The amount of detected energy necessary to show benefit using this type of NR algorithm was examined, as well as the necessary speed and frequency resolution of the gain manipulation. Design NR was performed using time-frequency gain manipulation, wherein the gains of individual frequency bands depended on the absence or presence of speech energy within each band. Three different experiments were performed: (1) NR using ideal detectors, (2) NR with nonideal detectors, and (3) NR with ideal detectors and different processing speeds and frequency resolutions. All experiments were performed using the Hearing-in-Noise test (HINT). A total of 6 listeners with normal hearing and 14 listeners with hearing loss were tested. Results HINT thresholds improved for all listeners with NR based on the ideal detectors used in Experiment I. The nonideal detectors of Experiment II required detection of at least 90% of the speech energy before an improvement was seen in HINT thresholds. The results of Experiment III demonstrated that relatively high temporal resolution (<100 msec) was required by the NR algorithm to improve HINT thresholds. Conclusions The results indicated that a single-microphone NR system based on time-frequency gain manipulation improved the HINT thresholds of listeners. However, to obtain benefit in speech intelligibility, the detectors used in such a strategy were required to detect an unrealistically high percentage of the speech energy and to perform the gain manipulations on a fast temporal basis. PMID:16957499

Development and Validation of a Novel Generic Health-related Quality of Life Instrument With 20 Items (HINT-20).

PubMed

Jo, Min-Woo; Lee, Hyeon-Jeong; Kim, Soo Young; Kim, Seon-Ha; Chang, Hyejung; Ahn, Jeonghoon; Ock, Minsu

2017-01-01

Few attempts have been made to develop a generic health-related quality of life (HRQoL) instrument and to examine its validity and reliability in Korea. We aimed to do this in our present study. After a literature review of existing generic HRQoL instruments, a focus group discussion, in-depth interviews, and expert consultations, we selected 30 tentative items for a new HRQoL measure. These items were evaluated by assessing their ceiling effects, difficulty, and redundancy in the first survey. To validate the HRQoL instrument that was developed, known-groups validity and convergent/discriminant validity were evaluated and its test-retest reliability was examined in the second survey. Of the 30 items originally assessed for the HRQoL instrument, four were excluded due to high ceiling effects and six were removed due to redundancy. We ultimately developed a HRQoL instrument with a reduced number of 20 items, known as the Health-related Quality of Life Instrument with 20 items (HINT-20), incorporating physical, mental, social, and positive health dimensions. The results of the HINT-20 for known-groups validity were poorer in women, the elderly, and those with a low income. For convergent/discriminant validity, the correlation coefficients of items (except vitality) in the physical health dimension with the physical component summary of the Short Form 36 version 2 (SF-36v2) were generally higher than the correlations of those items with the mental component summary of the SF-36v2, and vice versa. Regarding test-retest reliability, the intraclass correlation coefficient of the total HINT-20 score was 0.813 (p<0.001). A novel generic HRQoL instrument, the HINT-20, was developed for the Korean general population and showed acceptable validity and reliability.

Diagnosing Stroke in Acute Vertigo: The HINTS Family of Eye Movement Tests and the Future of the "Eye ECG".

PubMed

Newman-Toker, David E; Curthoys, Ian S; Halmagyi, G Michael

2015-10-01

Patients who present to the emergency department with symptoms of acute vertigo or dizziness are frequently misdiagnosed. Missed opportunities to promptly treat dangerous strokes can result in poor clinical outcomes. Inappropriate testing and incorrect treatments for those with benign peripheral vestibular disorders leads to patient harm and unnecessary costs. Over the past decade, novel bedside approaches to diagnose patients with the acute vestibular syndrome have been developed and refined. A battery of three bedside tests of ocular motor physiology known as "HINTS" (head impulse, nystagmus, test of skew) has been shown to identify acute strokes more accurately than even magnetic resonance imaging with diffusion-weighted imaging (MRI-DWI) when applied in the early acute period by eye-movement specialists. Recent advances in lightweight, high-speed video-oculography (VOG) technology have made possible a future in which HINTS might be applied by nonspecialists in frontline care settings using portable VOG. Use of technology to measure eye movements (VOG-HINTS) to diagnose stroke in the acute vestibular syndrome is analogous to the use of electrocardiography (ECG) to diagnose myocardial infarction in acute chest pain. This "eye ECG" approach could transform care for patients with acute vertigo and dizziness around the world. In the United States alone, successful implementation would likely result in improved quality of emergency care for hundreds of thousands of peripheral vestibular patients and tens of thousands of stroke patients, as well as an estimated national health care savings of roughly $1 billion per year. In this article, the authors review the origins of the HINTS approach, empiric evidence and pathophysiologic principles supporting its use, and possible uses for the eye ECG in teleconsultation, teaching, and triage. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

25 CFR 547.12 - What are the minimum technical standards for downloading on a Class II gaming system?

Code of Federal Regulations, 2010 CFR

2010-04-01

... OF CLASS II GAMES § 547.12 What are the minimum technical standards for downloading on a Class II... software, files, data, and prize schedules. (2) Downloads of software, games, prize schedules, or other... performed in a manner that will not affect game play. (5) Downloads shall not affect the integrity of...

25 CFR 547.12 - What are the minimum technical standards for downloading on a Class II gaming system?

Code of Federal Regulations, 2011 CFR

2011-04-01

... OF CLASS II GAMES § 547.12 What are the minimum technical standards for downloading on a Class II... software, files, data, and prize schedules. (2) Downloads of software, games, prize schedules, or other... performed in a manner that will not affect game play. (5) Downloads shall not affect the integrity of...

25 CFR 547.12 - What are the minimum technical standards for downloading on a Class II gaming system?

Code of Federal Regulations, 2012 CFR

2012-04-01

... OF CLASS II GAMES § 547.12 What are the minimum technical standards for downloading on a Class II... software, files, data, and prize schedules. (2) Downloads of software, games, prize schedules, or other... performed in a manner that will not affect game play. (5) Downloads shall not affect the integrity of...

Technical Support | Division of Cancer Prevention

Cancer.gov

To view the live webinar, you will need to have the software, Microsoft Live Meeting, downloaded onto your computer before the event. In most cases, the software will automatically download when you open the program on your system. However, in the event that you need to download it manually, you can access the software at the link below: Download the Microsoft Office Live

New insights into insight: Neurophysiological correlates of the difference between the intrinsic "aha" and the extrinsic "oh yes" moment.

PubMed

Rothmaler, Katrin; Nigbur, Roland; Ivanova, Galina

2017-01-27

Insight refers to a situation in which a problem solver immediately changes his understanding of a problem situation. This representational change can either be triggered by external stimuli, like a hint or the solution itself, or by internal solution attempts. In the present paper, the differences and similarities between these two phenomena, namely "extrinsic" and "intrinsic" insight, are examined. To this end, electroencephalogram (EEG) is recorded while subjects either recognize or generate solutions to German verbal compound remote associate problems (CRA). Based on previous studies, we compare the alpha power prior to insightful solution recognition with the alpha power prior to insightful solution generation. Results show that intrinsic insights are preceded by an increase in alpha power at right parietal electrodes, while extrinsic insights are preceded by a respective decrease. These results can be interpreted in two ways. In consistency with other studies, the increase in alpha power before intrinsic insights can be interpreted as an increased internal focus of attention. Accordingly, the decrease in alpha power before extrinsic insights may be associated with a more externally oriented focus of attention. Alternatively, the increase in alpha power prior to intrinsic insights can be interpreted as an active inhibition of solution-related information, while the alpha power decrease prior to extrinsic insights may reflect its activation. Regardless of the interpretation, the results provide strong evidence that extrinsic and intrinsic insight differ on the behavioral as well as the neurophysiological level. Copyright © 2016 Elsevier Ltd. All rights reserved.

Generation of Tutorial Dialogues: Discourse Strategies for Active Learning

DTIC Science & Technology

1998-05-29

AND SUBTITLE Generation of Tutorial Dialogues: Discourse Strategies for active Learning AUTHORS Dr. Martha Evens 7. PERFORMING ORGANI2ATION NAME...time the student starts in on a new topic. Michael and Rovick constantly attempt to promote active learning . They regularly use hints and only resort...Controlling active learning : How tutors decide when to generate hints. Proceedings of FLAIRS 󈨣. Melbourne Beach, FL. 157-161. Hume, G., Michael

Some decks are better than others: the effect of reinforcer type and task instructions on learning in the Iowa Gambling Task.

PubMed

Fernie, Gordon; Tunney, Richard J

2006-02-01

The Iowa Gambling Task (Bechara, Damasio, Damasio, & Anderson, 1994) has become widely used as a laboratory test of "real-life" decision-making. However, aspects of its administration that have been varied by researchers may differentially affect performance and the conclusions researchers can draw. Some researchers have used facsimile money reinforcers while others have used real money reinforcers. More importantly, the instructions participants receive have also been varied. While no differences have been reported in performance dependent on reinforcer type, no previous comparison of participants' instructions has been conducted. This is despite one set of instructions giving participants a clear hint about the nature of the task. Additionally, in previous research one set of instructions have not been used exclusively with one reinforcer type making any differential or cumulative effects of these factors difficult to interpret. The present study compared the effects of instruction and reinforcer type on IGT performance. When participants received instructions without a hint performance was affected by reinforcer type. This was not the case when the instructions included a hint. In a second IGT session performance was improved in participants who had received the hint instructions compared with those who had not.

A Time Series Analysis of Cancer-Related Information Seeking: Hints From the Health Information National Trends Survey (HINTS) 2003-2014.

PubMed

Huerta, Timothy R; Walker, Daniel M; Johnson, Tyler; Ford, Eric W

2016-09-01

Recent technological changes, such as the growth of the Internet, have made cancer information widely available. However, it remains unknown whether changes in access have resulted in concomitant changes in information seeking behavior. Previous work explored the cancer information seeking behaviors of the general population using the 2003 Health Information National Trends Survey (HINTS). This article aims to reproduce, replicate, and extend that existing analysis using the original dataset and five additional iterations of HINTS (2007, 2011, 2012, 2013, 2014). This approach builds on the earlier work by quantifying the magnitude of change in information seeking behaviors. Bivariate comparison of the 2003 and 2014 data revealed very similar results; however, the multivariate model including all years of data indicated differences between the original and extended models: individuals age 65 and older were no longer less likely to seek cancer information than the 18-35 reference population, and Hispanics were also no longer less likely to be cancer information seekers. The results of our analysis indicate an overall shift in cancer information seeking behaviors and also illuminate the impact of increased Internet usage over the past decade, suggesting specific demographic groups that may benefit from cancer information seeking encouragement.

Hip Replacement Surgery

MedlinePlus

... Download Download EPUB Download PDF What is it? Points To Remember About Hip Replacement Surgery Hip replacement ... This leaves your hands and arms free for balance or to use crutches. Use a long-handled " ...

Growth Plate Injuries

MedlinePlus

... Download Download EPUB Download PDF What are they? Points To Remember About Growth Plate Injuries Injuries to ... Neurological disorders that cause people to lose their balance and fall. Some inherited disorders. Bone infections. Metabolic ...

Learning and Behavior

MedlinePlus

... Aggression Sensory Processing Disorder Social Interactions Book: The Psychology of Duchenne (download) Guide: Learning & Behavior (download) Home ❯ ... a teen and adult. Additional Resources Book: The Psychology of Duchenne (download) Education Matters Guide: Learning & Behavior ( ...

Postpartum Depression Facts

MedlinePlus

... Where can I find more information? Share Postpartum Depression Facts Download PDF Download ePub Download Mobi Order ... for herself or her family. What is postpartum depression? Postpartum depression is a mood disorder that can ...

What Is Reactive Arthritis?

MedlinePlus

... Breadcrumb Home Health Topics Reactive Arthritis English Español Reactive Arthritis Basics In-Depth Download Download EPUB Download PDF What is it? Points To Remember About Reactive Arthritis Reactive arthritis is pain or swelling in ...

Normal Pancreas Anatomy

MedlinePlus

... hyphen, e.g. -historical Searches are case-insensitive Pancreas Anatomy Add to My Pictures View /Download : Small: ... 1586x1534 View Download Large: 3172x3068 View Download Title: Pancreas Anatomy Description: Anatomy of the pancreas; drawing shows ...

BenMAP Downloads

EPA Pesticide Factsheets

Download the current and legacy versions of the BenMAP program. Download configuration and aggregation/pooling/valuation files to estimate benefits. BenMAP-CE is free and open source software, and the source code is available upon request.

Internet-based interface for STRMDEPL08

USGS Publications Warehouse

Reeves, Howard W.; Asher, A. Jeremiah

2010-01-01

The core of the computer program STRMDEPL08 that estimates streamflow depletion by a pumping well with one of four analytical solutions was re-written in the Javascript software language and made available through an internet-based interface (web page). In the internet-based interface, the user enters data for one of the four analytical solutions, Glover and Balmer (1954), Hantush (1965), Hunt (1999), and Hunt (2003), and the solution is run for constant pumping for a desired number of simulation days. Results are returned in tabular form to the user. For intermittent pumping, the interface allows the user to request that the header information for an input file for the stand-alone executable STRMDEPL08 be created. The user would add the pumping information to this header information and run the STRMDEPL08 executable that is available for download through the U.S. Geological Survey. Results for the internet-based and stand-alone versions of STRMDEPL08 are shown to match.

Osteoarthritis

MedlinePlus

... Topics Osteoarthritis English Español 繁體中文 한국어 tiếng Việt Osteoarthritis Basics In-Depth Download Download EPUB Download PDF What is it? Points To Remember About Osteoarthritis Osteoarthritis is a disease that damages the slippery ...

Alternative Fuels Data Center: Hydrogen Drive

Science.gov Websites

, contact Greater Washington Region Clean Cities Coalition. Download QuickTime Video QuickTime (.mov ) Download Windows Media Video Windows Media (.wmv) Video Download Help Text version See more videos provided

An automatically updateable web publishing solution: taking document sharing and conversion to enterprise level

NASA Astrophysics Data System (ADS)

Rahman, Fuad; Tarnikova, Yuliya; Hartono, Rachmat; Alam, Hassan

2006-01-01

This paper presents a novel automatic web publishing solution, Pageview (R). PageView (R) is a complete working solution for document processing and management. The principal aim of this tool is to allow workgroups to share, access and publish documents on-line on a regular basis. For example, assuming that a person is working on some documents. The user will, in some fashion, organize his work either in his own local directory or in a shared network drive. Now extend that concept to a workgroup. Within a workgroup, some users are working together on some documents, and they are saving them in a directory structure somewhere on a document repository. The next stage of this reasoning is that a workgroup is working on some documents, and they want to publish them routinely on-line. Now it may happen that they are using different editing tools, different software, and different graphics tools. The resultant documents may be in PDF, Microsoft Office (R), HTML, or Word Perfect format, just to name a few. In general, this process needs the documents to be processed in a fashion so that they are in the HTML format, and then a web designer needs to work on that collection to make them available on-line. PageView (R) takes care of this whole process automatically, making the document workflow clean and easy to follow. PageView (R) Server publishes documents, complete with the directory structure, for online use. The documents are automatically converted to HTML and PDF so that users can view the content without downloading the original files, or having to download browser plug-ins. Once published, other users can access the documents as if they are accessing them from their local folders. The paper will describe the complete working system and will discuss possible applications within the document management research.

Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP).

PubMed

Guranowski, Andrzej; Wojdyła, Anna Maria; Zimny, Jarosław; Wypijewska, Anna; Kowalska, Joanna; Jemielity, Jacek; Davis, Richard E; Bieganowski, Paweł

2010-01-04

Histidine triad (HIT)-family proteins interact with different mono- and dinucleotides and catalyze their hydrolysis. During a study of the substrate specificity of seven HIT-family proteins, we have shown that each can act as a sulfohydrolase, catalyzing the liberation of AMP from adenosine 5'-phosphosulfate (APS or SO(4)-pA). However, in the presence of orthophosphate, Arabidopsis thaliana Hint4 and Caenorhabditis elegans DcpS also behaved as APS phosphorylases, forming ADP. Low pH promoted the phosphorolytic and high pH the hydrolytic activities. These proteins, and in particular Hint4, also catalyzed hydrolysis or phosphorolysis of some other adenylyl-derivatives but at lower rates than those for APS cleavage. A mechanism for these activities is proposed and the possible role of some HIT-proteins in APS metabolism is discussed.

Triassic–Jurassic climate in continental high-latitude Asia was dominated by obliquity-paced variations (Junggar Basin, Ürümqi, China)

PubMed Central

Sha, Jingeng; Olsen, Paul E.; Pan, Yanhong; Xu, Daoyi; Wang, Yaqiang; Zhang, Xiaolin; Yao, Xiaogang; Vajda, Vivi

2015-01-01

Empirical constraints on orbital gravitational solutions for the Solar System can be derived from the Earth’s geological record of past climates. Lithologically based paleoclimate data from the thick, coal-bearing, fluvial-lacustrine sequences of the Junggar Basin of Northwestern China (paleolatitude ∼60°) show that climate variability of the warm and glacier-free high latitudes of the latest Triassic–Early Jurassic (∼198–202 Ma) Pangea was strongly paced by obliquity-dominated (∼40 ky) orbital cyclicity, based on an age model using the 405-ky cycle of eccentricity. In contrast, coeval low-latitude continental climate was much more strongly paced by climatic precession, with virtually no hint of obliquity. Although this previously unknown obliquity dominance at high latitude is not necessarily unexpected in a high CO2 world, these data deviate substantially from published orbital solutions in period and amplitude for eccentricity cycles greater than 405 ky, consistent with chaotic diffusion of the Solar System. In contrast, there are indications that the Earth–Mars orbital resonance was in today’s 2-to-1 ratio of eccentricity to inclination. These empirical data underscore the need for temporally comprehensive, highly reliable data, as well as new gravitational solutions fitting those data. PMID:25759439

Triassic-Jurassic climate in continental high-latitude Asia was dominated by obliquity-paced variations (Junggar Basin, Ürümqi, China).

PubMed

Sha, Jingeng; Olsen, Paul E; Pan, Yanhong; Xu, Daoyi; Wang, Yaqiang; Zhang, Xiaolin; Yao, Xiaogang; Vajda, Vivi

2015-03-24

Empirical constraints on orbital gravitational solutions for the Solar System can be derived from the Earth's geological record of past climates. Lithologically based paleoclimate data from the thick, coal-bearing, fluvial-lacustrine sequences of the Junggar Basin of Northwestern China (paleolatitude ∼60°) show that climate variability of the warm and glacier-free high latitudes of the latest Triassic-Early Jurassic (∼198-202 Ma) Pangea was strongly paced by obliquity-dominated (∼40 ky) orbital cyclicity, based on an age model using the 405-ky cycle of eccentricity. In contrast, coeval low-latitude continental climate was much more strongly paced by climatic precession, with virtually no hint of obliquity. Although this previously unknown obliquity dominance at high latitude is not necessarily unexpected in a high CO2 world, these data deviate substantially from published orbital solutions in period and amplitude for eccentricity cycles greater than 405 ky, consistent with chaotic diffusion of the Solar System. In contrast, there are indications that the Earth-Mars orbital resonance was in today's 2-to-1 ratio of eccentricity to inclination. These empirical data underscore the need for temporally comprehensive, highly reliable data, as well as new gravitational solutions fitting those data.

Normal Female Reproductive Anatomy

MedlinePlus

... hyphen, e.g. -historical Searches are case-insensitive Reproductive System, Female, Anatomy Add to My Pictures View /Download : ... 1500x1575 View Download Large: 3000x3150 View Download Title: Reproductive System, Female, Anatomy Description: Anatomy of the female reproductive ...

CADDIS Volume 4. Data Analysis: Download Software

EPA Pesticide Factsheets

Overview of the data analysis tools available for download on CADDIS. Provides instructions for downloading and installing CADStat, access to Microsoft Excel macro for computing SSDs, a brief overview of command line use of R, a statistical software.

Providing accurate near real-time fire alerts for Protected Areas through NASA FIRMS: Opportunities and Challenges

NASA Astrophysics Data System (ADS)

Ilavajhala, S.; Davies, D.; Schmaltz, J. E.; Wong, M.; Murphy, K. J.

2013-12-01

The NASA Fire Information for Resource Management System (FIRMS) is at the forefront of providing global near real-time (NRT) MODIS thermal anomalies / hotspot location data to end-users . FIRMS serves the data via an interactive Web GIS named Web Fire Mapper, downloads of NRT active fire, archive data downloads for MODIS hotspots dating back to 1999 and a hotspot email alert system The FIRMS Email Alerts system has been successfully alerting users of fires in their area of interest in near real-time and/or via daily and weekly email summaries, with an option to receive MODIS hotspot data as a text file (CSV) attachment. Currently, there are more than 7000 email alert subscriptions from more than 100 countries. Specifically, the email alerts system is designed to generate and send an email alert for any region or area on the globe, with a special focus on providing alerts for protected areas worldwide. For many protected areas, email alerts are particularly useful for early fire detection, monitoring on going fires, as well as allocating resources to protect wildlife and natural resources of particular value. For protected areas, FIRMS uses the World Database on Protected Areas (WDPA) supplied by United Nations Environment Program - World Conservation Monitoring Centre (UNEP-WCMC). Maintaining the most up-to-date, accurate boundary geometry for the protected areas for the email alerts is a challenge as the WDPA is continuously updated due to changing boundaries, merging or delisting of certain protected areas. Because of this dynamic nature of the protected areas database, the FIRMS protected areas database is frequently out-of-date with the most current version of WDPA database. To maintain the most up-to-date boundary information for protected areas and to be in compliance with the WDPA terms and conditions, FIRMS needs to constantly update its database of protected areas. Currently, FIRMS strives to keep its database up to date by downloading the most recent WDPA database at regular intervals, processing it, and ingesting it into the FIRMS spatial database. However, due to the large size of database, the process to download, process and ingest the database is quite time consuming. The FIRMS team is currently working on developing a method to update the protected areas database via web at regular intervals or on-demand. Using such a solution, FIRMS will be able access the most up-to-date extents of any protected area and the corresponding spatial geometries in real time. As such, FIRMS can utilize such a service to access the protected areas and their associated geometries to keep users' protected area boundaries in sync with those of the most recent WDPA database, and thus serve a more accurate email alert to the users. Furthermore, any client accessing the WDPA protected areas database could potentially use the solution of real-time access to the protected areas database. This talk primarily focuses on the challenges for FIRMS in sending accurate email alerts for protected areas, along with the solution the FIRMS team is developing. This talk also introduces the FIRMS fire information system and its components, with a special emphasis on the FIRMS email alerts system.

Rheumatoid Arthritis

MedlinePlus

... Rheumatoid Arthritis English Español 繁體中文 한국어 tiếng Việt Rheumatoid Arthritis Basics In-Depth Download Download EPUB Download PDF What is it? Points To Remember About Rheumatoid Arthritis Rheumatoid arthritis is a disease that causes pain, ...

37 CFR 385.11 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 385.11 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS RATES AND... MAKING AND DISTRIBUTING OF PHYSICAL AND DIGITAL PHONORECORDS Interactive Streaming and Limited Downloads... interactive streams or limited downloads of musical works, as applicable. Limited download means a digital...

Translations on USSR Military Affairs, Number 1328.

DTIC Science & Technology

1978-02-02

of his age. This news came as no surprise to Mikhail Vasil’yevich, and he reported to the commander his readiness immediately to begin the transfer...for this period, in which regard he dropped a hint to the commander. 103 Major Labushev did not take the hint. Convinced that there was no mutual...District. It was directed thence to the garrison judge advocate, who sent Mikhail Vasil’yevich an encouraging letter. It declared that his unit

The learning effects of different presentations of worked examples on medical students' breaking-bad-news skills: A randomized and blinded field trial.

PubMed

Schmitz, Felix Michael; Schnabel, Kai Philipp; Bauer, Daniel; Bachmann, Cadja; Woermann, Ulrich; Guttormsen, Sissel

2018-02-24

Effective instructional approaches are needed to enable undergraduates to optimally prepare for the limited training time they receive with simulated patients (SPs). This study examines the learning effects of different presentation formats of a worked example on student SP communication. Sixty-seven fourth-year medical students attending a mandatory communication course participated in this randomized field trial. Prior to the course, they worked through an e-learning module that introduced the SPIKES protocol for delivering bad news to patients. In this module, a single worked example was presented to one group of students in a text version, to a second group in a video version, and to a third group in a video version enriched with text hints denoting the SPIKES steps. The video-with-hints group broke bad news to SPs significantly more appropriately than either of the other groups. Although no further condition-related effects were revealed, students who learned from the text version most frequently (although non-significantly) ignored unpleasant emotions (standardised emotional cues and concerns) expressed by the SPs. The learning effect was strongest when the video-based worked example was accompanied by hints. Video-related learning approaches that embed attention-guiding hints can effectively prepare undergraduates for SP encounters. Copyright © 2018 Elsevier B.V. All rights reserved.

The Internet: How Fast Can You Download?

ERIC Educational Resources Information Center

Shearer, Ron

1997-01-01

Discusses faster modems for downloading information from the Internet that may become available through cable or telephone industries. Topics include ADSL (Asymmetric Digital Subscriber Line) modems; Direct PC--downloading satellite transmissions; Land Multichannel Distribution System (LMDS)--a wireless communication device; and Internet…

How the Scientific Community Reacts to Newly Submitted Preprints: Article Downloads, Twitter Mentions, and Citations

PubMed Central

Shuai, Xin; Pepe, Alberto; Bollen, Johan

2012-01-01

We analyze the online response to the preprint publication of a cohort of 4,606 scientific articles submitted to the preprint database arXiv.org between October 2010 and May 2011. We study three forms of responses to these preprints: downloads on the arXiv.org site, mentions on the social media site Twitter, and early citations in the scholarly record. We perform two analyses. First, we analyze the delay and time span of article downloads and Twitter mentions following submission, to understand the temporal configuration of these reactions and whether one precedes or follows the other. Second, we run regression and correlation tests to investigate the relationship between Twitter mentions, arXiv downloads, and article citations. We find that Twitter mentions and arXiv downloads of scholarly articles follow two distinct temporal patterns of activity, with Twitter mentions having shorter delays and narrower time spans than arXiv downloads. We also find that the volume of Twitter mentions is statistically correlated with arXiv downloads and early citations just months after the publication of a preprint, with a possible bias that favors highly mentioned articles. PMID:23133597

Query-Biased Preview over Outsourced and Encrypted Data

PubMed Central

Luo, Guangchun; Qin, Ke; Chen, Aiguo

2013-01-01

For both convenience and security, more and more users encrypt their sensitive data before outsourcing it to a third party such as cloud storage service. However, searching for the desired documents becomes problematic since it is costly to download and decrypt each possibly needed document to check if it contains the desired content. An informative query-biased preview feature, as applied in modern search engine, could help the users to learn about the content without downloading the entire document. However, when the data are encrypted, securely extracting a keyword-in-context snippet from the data as a preview becomes a challenge. Based on private information retrieval protocol and the core concept of searchable encryption, we propose a single-server and two-round solution to securely obtain a query-biased snippet over the encrypted data from the server. We achieve this novel result by making a document (plaintext) previewable under any cryptosystem and constructing a secure index to support dynamic computation for a best matched snippet when queried by some keywords. For each document, the scheme has O(d) storage complexity and O(log(d/s) + s + d/s) communication complexity, where d is the document size and s is the snippet length. PMID:24078798

Query-biased preview over outsourced and encrypted data.

PubMed

Peng, Ningduo; Luo, Guangchun; Qin, Ke; Chen, Aiguo

2013-01-01

For both convenience and security, more and more users encrypt their sensitive data before outsourcing it to a third party such as cloud storage service. However, searching for the desired documents becomes problematic since it is costly to download and decrypt each possibly needed document to check if it contains the desired content. An informative query-biased preview feature, as applied in modern search engine, could help the users to learn about the content without downloading the entire document. However, when the data are encrypted, securely extracting a keyword-in-context snippet from the data as a preview becomes a challenge. Based on private information retrieval protocol and the core concept of searchable encryption, we propose a single-server and two-round solution to securely obtain a query-biased snippet over the encrypted data from the server. We achieve this novel result by making a document (plaintext) previewable under any cryptosystem and constructing a secure index to support dynamic computation for a best matched snippet when queried by some keywords. For each document, the scheme has O(d) storage complexity and O(log(d/s) + s + d/s) communication complexity, where d is the document size and s is the snippet length.

Teaching Resources

Science.gov Websites

& Legislation Links Discussion Lists Quick Links AAPT eMentoring ComPADRE Review of High School Take Physics" Poster Why Physics Poster Thumbnail Download normal resolution JPEG Download high resolution JPEG Download Spanish Version Recruiting Physics Students in High School (FED newsletter article

Development and Validation of a Novel Generic Health-related Quality of Life Instrument With 20 Items (HINT-20)

PubMed Central

2017-01-01

Objectives Few attempts have been made to develop a generic health-related quality of life (HRQoL) instrument and to examine its validity and reliability in Korea. We aimed to do this in our present study. Methods After a literature review of existing generic HRQoL instruments, a focus group discussion, in-depth interviews, and expert consultations, we selected 30 tentative items for a new HRQoL measure. These items were evaluated by assessing their ceiling effects, difficulty, and redundancy in the first survey. To validate the HRQoL instrument that was developed, known-groups validity and convergent/discriminant validity were evaluated and its test-retest reliability was examined in the second survey. Results Of the 30 items originally assessed for the HRQoL instrument, four were excluded due to high ceiling effects and six were removed due to redundancy. We ultimately developed a HRQoL instrument with a reduced number of 20 items, known as the Health-related Quality of Life Instrument with 20 items (HINT-20), incorporating physical, mental, social, and positive health dimensions. The results of the HINT-20 for known-groups validity were poorer in women, the elderly, and those with a low income. For convergent/discriminant validity, the correlation coefficients of items (except vitality) in the physical health dimension with the physical component summary of the Short Form 36 version 2 (SF-36v2) were generally higher than the correlations of those items with the mental component summary of the SF-36v2, and vice versa. Regarding test-retest reliability, the intraclass correlation coefficient of the total HINT-20 score was 0.813 (p<0.001). Conclusions A novel generic HRQoL instrument, the HINT-20, was developed for the Korean general population and showed acceptable validity and reliability. PMID:28173686

Expert Involvement Predicts mHealth App Downloads: Multivariate Regression Analysis of Urology Apps

PubMed Central

Osório, Luís; Cavadas, Vitor; Fraga, Avelino; Carrasquinho, Eduardo; Cardoso de Oliveira, Eduardo; Castelo-Branco, Miguel; Roobol, Monique J

2016-01-01

Background Urological mobile medical (mHealth) apps are gaining popularity with both clinicians and patients. mHealth is a rapidly evolving and heterogeneous field, with some urology apps being downloaded over 10,000 times and others not at all. The factors that contribute to medical app downloads have yet to be identified, including the hypothetical influence of expert involvement in app development. Objective The objective of our study was to identify predictors of the number of urology app downloads. Methods We reviewed urology apps available in the Google Play Store and collected publicly available data. Multivariate ordinal logistic regression evaluated the effect of publicly available app variables on the number of apps being downloaded. Results Of 129 urology apps eligible for study, only 2 (1.6%) had >10,000 downloads, with half having ≤100 downloads and 4 (3.1%) having none at all. Apps developed with expert urologist involvement (P=.003), optional in-app purchases (P=.01), higher user rating (P<.001), and more user reviews (P<.001) were more likely to be installed. App cost was inversely related to the number of downloads (P<.001). Only data from the Google Play Store and the developers’ websites, but not other platforms, were publicly available for analysis, and the level and nature of expert involvement was not documented. Conclusions The explicit participation of urologists in app development is likely to enhance its chances to have a higher number of downloads. This finding should help in the design of better apps and further promote urologist involvement in mHealth. Official certification processes are required to ensure app quality and user safety. PMID:27421338

What are we reading? A study of downloaded and cited articles from the British Journal of Oral and Maxillofacial Surgery in 2010.

PubMed

Brennan, Peter A; Habib, Ahmed

2011-10-01

A large number of papers related to oral and maxillofacial surgery are published in many specialist journals. With the ever-increasing use of the internet it is easy to download them as part of a journal subscription on a fee per paper basis, or in some cases for free. Online access to the British Journal of Oral and Maxillofacial Surgery (BJOMS) is free to British Association (BAOMS) members with a $30 fee per paper download for non-members. Many colleagues use the online version of the journal, and this provides valuable information about downloading trends. Other data on articles that have been cited in subsequent publications are also readily available, and they form the basis for the calculation of a journal's impact factor. We evaluated the top 50 downloaded papers from the BJOMS website in 2010 to ascertain which articles were being read online. We also obtained data on the number of citations for papers published in 2009-2010 to see whether these papers were similar to the articles being downloaded. In 2010 there were over 360000 downloaded articles. The most popular papers were leading articles, reviews, and full length articles; only one short communication featured in the top 50 downloads. The papers most cited in subsequent publications were full length articles and leading articles or reviews, which represent 80% of the total citations of the 50 papers. Ten papers were in both the top 50 downloaded and most cited lists. We discuss the implications of this study for the journal and our readers. Copyright © 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Performance Evaluation of Peer-to-Peer Progressive Download in Broadband Access Networks

NASA Astrophysics Data System (ADS)

Shibuya, Megumi; Ogishi, Tomohiko; Yamamoto, Shu

P2P (Peer-to-Peer) file sharing architectures have scalable and cost-effective features. Hence, the application of P2P architectures to media streaming is attractive and expected to be an alternative to the current video streaming using IP multicast or content delivery systems because the current systems require expensive network infrastructures and large scale centralized cache storage systems. In this paper, we investigate the P2P progressive download enabling Internet video streaming services. We demonstrated the capability of the P2P progressive download in both laboratory test network as well as in the Internet. Through the experiments, we clarified the contribution of the FTTH links to the P2P progressive download in the heterogeneous access networks consisting of FTTH and ADSL links. We analyzed the cause of some download performance degradation occurred in the experiment and discussed about the effective methods to provide the video streaming service using P2P progressive download in the current heterogeneous networks.

The Scope of Direct Alkylation of Gold Surface with Solutions of C1-C4 n-Alkylstannanes.

PubMed

Kaletová, Eva; Kohutová, Anna; Hajduch, Jan; Kaleta, Jiří; Bastl, Zdeněk; Pospíšil, Lubomír; Stibor, Ivan; Magnera, Thomas F; Michl, Josef

2015-09-23

Treatment of cleaned gold surfaces with dilute tetrahydrofuran or chloroform solutions of tetraalkylstannanes (alkyl = methyl, ethyl, n-propyl, n-butyl) or di-n-butylmethylstannyl tosylate under ambient conditions causes a self-limited growth of disordered monolayers consisting of alkyls and tin oxide. Extensive use of deuterium labeling showed that the alkyls originate from the stannane and not from ambient impurities, and that trialkylstannyl groups are absent in the monolayers, contrary to previous proposals. Methyl groups attached to the Sn atom are not transferred to the surface. Ethyl groups are transferred slowly, and propyl and butyl rapidly. In all cases, tin oxide is codeposited in submonolayer amounts. The monolayers were characterized by ellipsometry, contact angle goniometry, polarization modulated IR reflection absorption spectroscopy, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy with ferrocyanide/ferricyanide, which revealed a very low charge-transfer resistance. The thermal stability of the monolayers and their resistance to solvents are comparable with those of an n-octadecanethiol monolayer. A preliminary examination of the kinetics of monolayer deposition from a THF solution of tetra-n-butylstannane revealed an approximately half-order dependence on the bulk solution concentration of the stannane, hinting that more than one alkyl can be transferred from a single stannane molecule. A detailed structure of the attachment of the alkyl groups is not known, and it is proposed that it involves direct single or multiple bonding of one or more C atoms to one or more Au atoms.

Brine Migration in Heated Salt: Lessons Learned from Field Experiments

NASA Astrophysics Data System (ADS)

Kuhlman, K. L.; Matteo, E. N.; Mills, M.

2017-12-01

We summarize several interesting brine migration related phenomena hinted at in field experiments from field testing related to salt radioactive waste repositories in Germany and the US. Past heater tests in salt have shown 1) thermal-hydrological-mechanical coupling is quite strong during both heating and cooling; 2) chemical composition of brine evolves during heating, and comprises a mix of several water sources; and 3) acid gas (HCl) generation has been observed during past heater tests and may have multiple mechanisms for formation. We present a heated brine migration test design, formulated with these complexities in mind. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia LLC, a wholly owned subsidiary of Honeywell International Inc. for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525.

Aqueous vanadium ion dynamics relevant to bioinorganic chemistry: A review.

PubMed

Kustin, Kenneth

2015-06-01

Aqueous solutions of the four highest vanadium oxidation states exhibit four diverse colors, which only hint at the diverse reactions that these ions can undergo. Cationic vanadium ions form complexes with ligands; anionic vanadium ions form complexes with ligands and self-react to form isopolyanions. All vanadium species undergo oxidation-reduction reactions. With a few exceptions, elucidation of the dynamics of these reactions awaited the development of fast reaction techniques before the kinetics of elementary ligation, condensation, reduction, and oxidation of the aqueous vanadium ions could be investigated. As the biological roles played by endogenous and therapeutic vanadium expand, it is appropriate to bring the results of the diverse kinetics studies under one umbrella. To achieve this goal this review presents a systematic examination of elementary aqueous vanadium ion dynamics. Copyright © 2014 Elsevier Inc. All rights reserved.

Academic Software Downloads from Google Code: Useful Usage Indicators?

ERIC Educational Resources Information Center

Thelwall, Mike; Kousha, Kayvan

2016-01-01

Introduction: Computer scientists and other researchers often make their programs freely available online. If this software makes a valuable contribution inside or outside of academia then its creators may want to demonstrate this with a suitable indicator, such as download counts. Methods: Download counts, citation counts, labels and licenses…

The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells.

PubMed

Lee, Yu-Nee; Nechushtan, Hovav; Figov, Navah; Razin, Ehud

2004-02-01

The involvement of microphthalmia transcription factor (MITF) in the function of mast cells, melanocytes, and osteoclasts has recently started to be investigated in depth. In a previous study, we found Hint to be associated with MITF in mast cells and showed that it suppresses MITF's transcriptional activity. Here, we have found that lysyl-tRNA synthetase (LysRS) is also associated with MITF and forms a multicomplex with MITF and Hint. We have also shown that Ap4A, an endogenous molecule consisting of two adenosine linked by four phosphate which is known to be synthesized by LysRS, is accumulated intracellularily above 700 microM in IgE-Ag-activated mast cells, binds to Hint, liberates MITF, and thus leads to the activation of MITF-dependent gene expression. This implies that LysRS plays a key role via Ap4A as an important signaling molecule in MITF transcriptional activity.

Wing download reduction using vortex trapping plates

NASA Technical Reports Server (NTRS)

Light, Jeffrey S.; Stremel, Paul M.; Bilanin, Alan J.

1994-01-01

A download reduction technique using spanwise plates on the upper and lower wing surfaces has been examined. Experimental and analytical techniques were used to determine the download reduction obtained using this technique. Simple two-dimensional wind tunnel testing confirmed the validity of the technique for reducing two-dimensional airfoil drag. Computations using a two-dimensional Navier-Stokes analysis provided insight into the mechanism causing the drag reduction. Finally, the download reduction technique was tested using a rotor and wing to determine the benefits for a semispan configuration representative of a tilt rotor aircraft.

Sampling and counting genome rearrangement scenarios

PubMed Central

2015-01-01

Background Even for moderate size inputs, there are a tremendous number of optimal rearrangement scenarios, regardless what the model is and which specific question is to be answered. Therefore giving one optimal solution might be misleading and cannot be used for statistical inferring. Statistically well funded methods are necessary to sample uniformly from the solution space and then a small number of samples are sufficient for statistical inferring. Contribution In this paper, we give a mini-review about the state-of-the-art of sampling and counting rearrangement scenarios, focusing on the reversal, DCJ and SCJ models. Above that, we also give a Gibbs sampler for sampling most parsimonious labeling of evolutionary trees under the SCJ model. The method has been implemented and tested on real life data. The software package together with example data can be downloaded from http://www.renyi.hu/~miklosi/SCJ-Gibbs/ PMID:26452124

A Hybrid Human-Computer Approach to the Extraction of Scientific Facts from the Literature.

PubMed

Tchoua, Roselyne B; Chard, Kyle; Audus, Debra; Qin, Jian; de Pablo, Juan; Foster, Ian

2016-01-01

A wealth of valuable data is locked within the millions of research articles published each year. Reading and extracting pertinent information from those articles has become an unmanageable task for scientists. This problem hinders scientific progress by making it hard to build on results buried in literature. Moreover, these data are loosely structured, encoded in manuscripts of various formats, embedded in different content types, and are, in general, not machine accessible. We present a hybrid human-computer solution for semi-automatically extracting scientific facts from literature. This solution combines an automated discovery, download, and extraction phase with a semi-expert crowd assembled from students to extract specific scientific facts. To evaluate our approach we apply it to a challenging molecular engineering scenario, extraction of a polymer property: the Flory-Huggins interaction parameter. We demonstrate useful contributions to a comprehensive database of polymer properties.

A complete solution classification and unified algorithmic treatment for the one- and two-step asymmetric S-transverse mass event scale statistic

NASA Astrophysics Data System (ADS)

Walker, Joel W.

2014-08-01

The M T2, or "s-transverse mass", statistic was developed to associate a parent mass scale to a missing transverse energy signature, given that escaping particles are generally expected in pairs, while collider experiments are sensitive to just a single transverse momentum vector sum. This document focuses on the generalized extension of that statistic to asymmetric one- and two-step decay chains, with arbitrary child particle masses and upstream missing transverse momentum. It provides a unified theoretical formulation, complete solution classification, taxonomy of critical points, and technical algorithmic prescription for treatment of the event scale. An implementation of the described algorithm is available for download, and is also a deployable component of the author's selection cut software package AEAC uS (Algorithmic Event Arbiter and C ut Selector). appendices address combinatoric event assembly, algorithm validation, and a complete pseudocode.

JHelioviewer: Open-Source Software for Discovery and Image Access in the Petabyte Age

NASA Astrophysics Data System (ADS)

Mueller, D.; Dimitoglou, G.; Garcia Ortiz, J.; Langenberg, M.; Nuhn, M.; Dau, A.; Pagel, S.; Schmidt, L.; Hughitt, V. K.; Ireland, J.; Fleck, B.

2011-12-01

The unprecedented torrent of data returned by the Solar Dynamics Observatory is both a blessing and a barrier: a blessing for making available data with significantly higher spatial and temporal resolution, but a barrier for scientists to access, browse and analyze them. With such staggering data volume, the data is accessible only from a few repositories and users have to deal with data sets effectively immobile and practically difficult to download. From a scientist's perspective this poses three challenges: accessing, browsing and finding interesting data while avoiding the proverbial search for a needle in a haystack. To address these challenges, we have developed JHelioviewer, an open-source visualization software that lets users browse large data volumes both as still images and movies. We did so by deploying an efficient image encoding, storage, and dissemination solution using the JPEG 2000 standard. This solution enables users to access remote images at different resolution levels as a single data stream. Users can view, manipulate, pan, zoom, and overlay JPEG 2000 compressed data quickly, without severe network bandwidth penalties. Besides viewing data, the browser provides third-party metadata and event catalog integration to quickly locate data of interest, as well as an interface to the Virtual Solar Observatory to download science-quality data. As part of the ESA/NASA Helioviewer Project, JHelioviewer offers intuitive ways to browse large amounts of heterogeneous data remotely and provides an extensible and customizable open-source platform for the scientific community. In addition, the easy-to-use graphical user interface enables the general public and educators to access, enjoy and reuse data from space missions without barriers.

Musician enhancement for speech-in-noise.

PubMed

Parbery-Clark, Alexandra; Skoe, Erika; Lam, Carrie; Kraus, Nina

2009-12-01

To investigate the effect of musical training on speech-in-noise (SIN) performance, a complex task requiring the integration of working memory and stream segregation as well as the detection of time-varying perceptual cues. Previous research has indicated that, in combination with lifelong experience with musical stream segregation, musicians have better auditory perceptual skills and working memory. It was hypothesized that musicians would benefit from these factors and perform better on speech perception in noise than age-matched nonmusician controls. The performance of 16 musicians and 15 nonmusicians was compared on clinical measures of speech perception in noise-QuickSIN and Hearing-In-Noise Test (HINT). Working memory capacity and frequency discrimination were also assessed. All participants had normal hearing and were between the ages of 19 and 31 yr. To be categorized as a musician, participants needed to have started musical training before the age of 7 yr, have 10 or more years of consistent musical experience, and have practiced more than three times weekly within the 3 yr before study enrollment. Nonmusicians were categorized by the failure to meet the musician criteria, along with not having received musical training within the 7 yr before the study. Musicians outperformed the nonmusicians on both QuickSIN and HINT, in addition to having more fine-grained frequency discrimination and better working memory. Years of consistent musical practice correlated positively with QuickSIN, working memory, and frequency discrimination but not HINT. The results also indicate that working memory and frequency discrimination are more important for QuickSIN than for HINT. Musical experience appears to enhance the ability to hear speech in challenging listening environments. Large group differences were found for QuickSIN, and the results also suggest that this enhancement is derived in part from musicians' enhanced working memory and frequency discrimination. For HINT, in which performance was not linked to frequency discrimination ability and was only moderately linked to working memory, musicians still performed significantly better than the nonmusicians. The group differences for HINT were evident in the most difficult condition in which the speech and noise were presented from the same location and not spatially segregated. Understanding which cognitive and psychoacoustic factors as well as which lifelong experiences contribute to SIN may lead to more effective remediation programs for clinical populations for whom SIN poses a particular perceptual challenge. These results provide further evidence for musical training transferring to nonmusical domains and highlight the importance of taking musical training into consideration when evaluating a person's SIN ability in a clinical setting.

Drive Cycle Data | Transportation Secure Data Center | NREL

Science.gov Websites

one file. Download Individual Survey and Study Drive Cycle Data Below you'll find drive cycle data download files for individual surveys and studies. Greater Fairbanks, Alaska, Transportation Survey Drive Cycle Data by Vehicle (24-hour period of operation) Download Learn more about the survey. California

On the Web, a Textbook Proliferation of Piracy

ERIC Educational Resources Information Center

Young, Jeffrey R.

2008-01-01

Book publishers are stepping up efforts to stop college students from downloading illegal copies of textbooks online. One Web site, Textbook Torrents, promises more than 5,000 textbooks for download in PDF format, complete with the original books' layouts and full-color illustrations. Users must simply set up a free account and download a free…

Graphing Online Searches with Lotus 1-2-3.

ERIC Educational Resources Information Center

Persson, Olle

1986-01-01

This article illustrates how Lotus 1-2-3 software can be used to create graphs using downloaded online searches as raw material, notes most commands applied, and outlines three required steps: downloading, importing the downloading file into the worksheet, and making graphs. An example in bibliometrics and sample graphs are included. (EJS)

Alternative Fuels Data Center: Schwan's Home Service Delivers With

Science.gov Websites

distribute products across the United States. For information about this project, contact Twin Cities Clean Cities Coalition. Download QuickTime Video QuickTime (.mov) Download Windows Media Video Windows Media (.wmv) Video Download Help Text version See more videos provided by Clean Cities TV and FuelEconomy.gov

Modes of Access: The Influence of Dissemination Channels on the Use of Open Access Monographs

ERIC Educational Resources Information Center

Snijder, Ronald

2014-01-01

Introduction: This paper studies the effects of several dissemination channels in an open access environment by analysing the download data of the OAPEN Library. Method: Download data were obtained containing the number of downloads and the name of the Internet provider. Based on public information, each Internet provider was categorised. The…

Alternative Fuels Data Center: Maine's Only Biodiesel Manufacturer Powers

Science.gov Websites

this project, contact Maine Clean Communities. Download QuickTime Video QuickTime (.mov) Download Windows Media Video Windows Media (.wmv) Video Download Help Text version See more videos provided by truck Krug Energy Opens Natural Gas Fueling Station in Arkansas June 18, 2016 photo of natural gas

Alternative Fuels Data Center: Texas Taxis Go Hybrid

Science.gov Websites

information about this project, contact Alamo Area Clean Cities (San Antonio). Download QuickTime Video QuickTime (.mov) Download Windows Media Video Windows Media (.wmv) Video Download Help Text version See more car Hydrogen Powers Fuel Cell Vehicles in California Nov. 18, 2017 Photo of a car Smart Car Shopping

Quantitative Thermochronology

NASA Astrophysics Data System (ADS)

Braun, Jean; van der Beek, Peter; Batt, Geoffrey

2006-05-01

Thermochronology, the study of the thermal history of rocks, enables us to quantify the nature and timing of tectonic processes. Quantitative Thermochronology is a robust review of isotopic ages, and presents a range of numerical modeling techniques to allow the physical implications of isotopic age data to be explored. The authors provide analytical, semi-analytical, and numerical solutions to the heat transfer equation in a range of tectonic settings and under varying boundary conditions. They then illustrate their modeling approach built around a large number of case studies. The benefits of different thermochronological techniques are also described. Computer programs on an accompanying website at www.cambridge.org/9780521830577 are introduced through the text and provide a means of solving the heat transport equation in the deforming Earth to predict the ages of rocks and compare them directly to geological and geochronological data. Several short tutorials, with hints and solutions, are also included. Numerous case studies help geologists to interpret age data and relate it to Earth processes Essential background material to aid understanding and using thermochronological data Provides a thorough treatise on numerical modeling of heat transport in the Earth's crust Supported by a website hosting relevant computer programs and colour slides of figures from the book for use in teaching

The testing effect and analogical problem-solving.

PubMed

Peterson, Daniel J; Wissman, Kathryn T

2018-06-25

Researchers generally agree that retrieval practice of previously learned material facilitates subsequent recall of same material, a phenomenon known as the testing effect. There is debate, however, about when such benefits transfer to related (though not identical) material. The current study examines the phenomenon of transfer in the domain of analogical problem-solving. In Experiments 1 and 2, learners were presented a source text describing a problem and solution to read which was subsequently either restudied or recalled. Following a short (Experiment 1) or long (Experiment 2) delay, learners were given a new target text and asked to solve a problem. The two texts shared a common structure such that the provided solution for the source text could be applied to solve the problem in the target text. In a combined analysis of both experiments, learners in the retrieval practice condition were more successful at solving the problem than those in the restudy condition. Experiment 3 explored the degree to which retrieval practice promotes cued versus spontaneous transfer by manipulating whether participants were provided with an explicit hint that the source and target texts were related. Results revealed no effect of retrieval practice.

Numerical simulation of nonlinear feedback model of saccade generation circuit implemented in the LabView graphical programming language.

PubMed

Jackson, M E; Gnadt, J W

1999-03-01

The object-oriented graphical programming language LabView was used to implement the numerical solution to a computational model of saccade generation in primates. The computational model simulates the activity and connectivity of anatomical strictures known to be involved in saccadic eye movements. The LabView program provides a graphical user interface to the model that makes it easy to observe and modify the behavior of each element of the model. Essential elements of the source code of the LabView program are presented and explained. A copy of the model is available for download from the internet.

Study of the Effectiveness of Multipurpose Solutions on the Bacterial Disinfection of Silicone Hydrogel Contact Lenses In Vitro.

PubMed

Correa, Priscila C; Lui, Aline C F; Silva, Cely B; Gracitelli, Carolina P B; Mimica, Lycia M; Sasagawa, Suzethe M; Netto, Adamo L

2017-10-12

To assess the antimicrobial effectiveness of multipurpose solutions in regard to the disinfection of silicone hydrogel contact lenses (CL) using a study of clinical bacterial isolates from ocular material. Three multipurpose solutions (solution A: polyhexamethylene biguanide 0.00025 g/100 mL; solution B: polyquaternary-1 0.001% and myristamidopropyl dimethylamine 0.0006%; and solution C: polyaminopropyl biguanide 0.00013% and polyquaternary 0.0001%) were used as a 3-phase disinfection on silicone hydrogel CL contaminated with bacteria from clinical isolates that were divided into five groups (group 1: Pseudomonas aeruginosa; group 2: Staphylococcus aureus; group 3: Staphylococcus epidermidis; group 4: Streptococcus spp; and group 5: enterobacteria). No differences were observed between the 24- and 48-hr measurements in any of the samples, and the positivity of microorganisms in T0 was 100% for all solutions; it was 0% in T3. Therefore, only steps T1 (rubbing followed by rinsing) and T2 (rubbing followed by rinsing and immersion of CL into solution) were considered for analysis at the 24-hr measurement time. Throughout the phases, a decrease in the number of bacteria was observed, culminating in the elimination (no recovery) of all microorganisms in the three solutions. At the end of the proposed process, the tested solutions were effective.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Alternative Fuels Data Center: America's Largest Home Runs on Biodiesel in

Science.gov Websites

Coalition (Western North Carolina). Download QuickTime Video QuickTime (.mov) Download Windows Media Video Windows Media (.wmv) Video Download Help Text version See more videos provided by Clean Cities TV and Photo of a car Hydrogen Powers Fuel Cell Vehicles in California Nov. 18, 2017 Photo of a car Smart Car

Alternative Fuels Data Center: Rhode Island EV Initiative Adds Chargers

Science.gov Websites

Ocean State Clean Cities. Download QuickTime Video QuickTime (.mov) Download Windows Media Video Windows Media (.wmv) Video Download Help Text version See more videos provided by Clean Cities TV and Photo of a car Hydrogen Powers Fuel Cell Vehicles in California Nov. 18, 2017 Photo of a car Smart Car

Alternative Fuels Data Center: Worcester Regional Transit Authority Drives

Science.gov Websites

Clean Cities. Download QuickTime Video QuickTime (.mov) Download Windows Media Video Windows Media (.wmv ) Video Download Help Text version See more videos provided by Clean Cities TV and FuelEconomy.gov Fuel Cell Vehicles in California Nov. 18, 2017 Photo of a car Smart Car Shopping Nov. 4, 2017 Image of

Alternative Fuels Data Center: Propane Powers Airport Shuttles in New

Science.gov Websites

Clean Fuel Partnership. Download QuickTime Video QuickTime (.mov) Download Windows Media Video Windows Media (.wmv) Video Download Help Text version See more videos provided by Clean Cities TV and Vehicles in California Nov. 18, 2017 Photo of a car Smart Car Shopping Nov. 4, 2017 Photo of a truck

If I tweet will you cite? The effect of social media exposure of articles on downloads and citations.

PubMed

Tonia, Thomy; Van Oyen, Herman; Berger, Anke; Schindler, Christian; Künzli, Nino

2016-05-01

We sought to investigate whether exposing scientific papers to social media (SM) has an effect on article downloads and citations. We randomized all International Journal of Public Health (IJPH) original articles published between December 2012 and December 2014 to SM exposure (blog post, Twitter and Facebook) or no exposure at three different time points after first online publication. 130 papers (SM exposure = 65, control = 65) were randomized. The number of downloads did not differ significantly between groups (p = 0.60) nor did the number of citations (p = 0.88). Adjusting for length of observation and paper's geographical origin did not change these results. There was no difference in the number of downloads and citations between the SM exposure and control group when we stratified for open access status. The number of downloads and number of citations were significantly correlated in both groups. SM exposure did not have a significant effect on traditional impact metrics, such as downloads and citations. However, other metrics may measure the added value that social media might offer to a scientific journal, such as wider dissemination.

[Peripheral vertigo versus central vertigo. Application of the HINTS protocol].

PubMed

Batuecas-Caletrío, Ángel; Yáñez-González, Raquel; Sánchez-Blanco, Carmen; González-Sánchez, Enrique; Benito, José; Gómez, José Carlos; Santa Cruz-Ruiz, Santiago

2014-10-16

One of the most important dilemmas concerning vertigo in emergency departments is its differential diagnosis. There are highly sensitive warning signs in the examination that can put us on the path towards finding ourselves before a case of central vertigo. To determine how effective the application of the HINTS protocol is in the diagnosis of cerebrovascular accidents that mimics peripheral vertigo. We conducted a descriptive observation-based study on patients admitted to hospital with a diagnosis of acute vestibular syndrome in the emergency department. All the patients were monitored on a day-to-day basis until their symptoms improved, with information about nystagmus, the oculocephalic manoeuvre and the skew test. The results from the magnetic resonance imaging study were compared with the alteration of any of those three signs during the time the patient was hospitalised. Altogether 91 patients were examined, with a mean age of 55.8 years. A cerebrovascular accident was observed in eight cases. Of these (mean age: 71 years), in seven of them there were alterations in some of the HINTS signs, and in one case the study was normal (sensitivity: 0.88; specificity: 0.96). All of them had some vascular risk factor. Faced with a patient who visits the emergency department with an acute vestibular syndrome, a suitably directed examination is essential to be able to establish the differential diagnosis between peripheral and central pathology, since some cerebrovascular accidents can present with the appearance of acute vertigo. Applying a protocol like HINTS makes it possible to suspect the central pathology with a high degree of sensitivity and specificity.

GenomeVIP: a cloud platform for genomic variant discovery and interpretation

PubMed Central

Mashl, R. Jay; Scott, Adam D.; Huang, Kuan-lin; Wyczalkowski, Matthew A.; Yoon, Christopher J.; Niu, Beifang; DeNardo, Erin; Yellapantula, Venkata D.; Handsaker, Robert E.; Chen, Ken; Koboldt, Daniel C.; Ye, Kai; Fenyö, David; Raphael, Benjamin J.; Wendl, Michael C.; Ding, Li

2017-01-01

Identifying genomic variants is a fundamental first step toward the understanding of the role of inherited and acquired variation in disease. The accelerating growth in the corpus of sequencing data that underpins such analysis is making the data-download bottleneck more evident, placing substantial burdens on the research community to keep pace. As a result, the search for alternative approaches to the traditional “download and analyze” paradigm on local computing resources has led to a rapidly growing demand for cloud-computing solutions for genomics analysis. Here, we introduce the Genome Variant Investigation Platform (GenomeVIP), an open-source framework for performing genomics variant discovery and annotation using cloud- or local high-performance computing infrastructure. GenomeVIP orchestrates the analysis of whole-genome and exome sequence data using a set of robust and popular task-specific tools, including VarScan, GATK, Pindel, BreakDancer, Strelka, and Genome STRiP, through a web interface. GenomeVIP has been used for genomic analysis in large-data projects such as the TCGA PanCanAtlas and in other projects, such as the ICGC Pilots, CPTAC, ICGC-TCGA DREAM Challenges, and the 1000 Genomes SV Project. Here, we demonstrate GenomeVIP's ability to provide high-confidence annotated somatic, germline, and de novo variants of potential biological significance using publicly available data sets. PMID:28522612

Interactive, Automated Management of Icing Data

NASA Technical Reports Server (NTRS)

Levinson, Laurie H.

2009-01-01

IceVal DatAssistant is software (see figure) that provides an automated, interactive solution for the management of data from research on aircraft icing. This software consists primarily of (1) a relational database component used to store ice shape and airfoil coordinates and associated data on operational and environmental test conditions and (2) a graphically oriented database access utility, used to upload, download, process, and/or display data selected by the user. The relational database component consists of a Microsoft Access 2003 database file with nine tables containing data of different types. Included in the database are the data for all publicly releasable ice tracings with complete and verifiable test conditions from experiments conducted to date in the Glenn Research Center Icing Research Tunnel. Ice shapes from computational simulations with the correspond ing conditions performed utilizing the latest version of the LEWICE ice shape prediction code are likewise included, and are linked to the equivalent experimental runs. The database access component includes ten Microsoft Visual Basic 6.0 (VB) form modules and three VB support modules. Together, these modules enable uploading, downloading, processing, and display of all data contained in the database. This component also affords the capability to perform various database maintenance functions for example, compacting the database or creating a new, fully initialized but empty database file.

Dynamics of Lysozyme in Trehalose solutions

NASA Astrophysics Data System (ADS)

Ghatty, Pavan; Uberbacher, Edward C.

2008-03-01

Anhydrobiosis in Tardigrades and Nematodes has been a topic of constant interest and intrigue in the scientific community. An increase in the concentration of Trehalose has been attributed to the ability of some organisms to survive extreme conditions of temperature, pressure and pH. Although there exist many experimental studies attributing this effect to Trehalose, the molecular details governing the interaction between Trehalose and proteins remains unclear. We have conducted a 20ns study of Lysozyme in varying concentrations of Trehalose in water. Strong and weak hydrogen bonds and hydrophobic interactions between water, Trehalose and protein seem to dictate the interactions in the system. We have observed a hydrogen bonded network of Trehalose around the protein entrapping a layer of water between itself and protein. Lysozyme remains in a near-native conformation throughout the simulation giving hints on the ability of Trehalose in preserving the structure of protiens.

Granularity analysis for mathematical proofs.

PubMed

Schiller, Marvin R G

2013-04-01

Mathematical proofs generally allow for various levels of detail and conciseness, such that they can be adapted for a particular audience or purpose. Using automated reasoning approaches for teaching proof construction in mathematics presupposes that the step size of proofs in such a system is appropriate within the teaching context. This work proposes a framework that supports the granularity analysis of mathematical proofs, to be used in the automated assessment of students' proof attempts and for the presentation of hints and solutions at a suitable pace. Models for granularity are represented by classifiers, which can be generated by hand or inferred from a corpus of sample judgments via machine-learning techniques. This latter procedure is studied by modeling granularity judgments from four experts. The results provide support for the granularity of assertion-level proofs but also illustrate a degree of subjectivity in assessing step size. Copyright © 2013 Cognitive Science Society, Inc.

Experimental evidence of a helical, supercritical instability in pipe flow of shear thinning fluids

NASA Astrophysics Data System (ADS)

Picaut, L.; Ronsin, O.; Caroli, C.; Baumberger, T.

2017-08-01

We study experimentally the flow stability of entangled polymer solutions extruded through glass capillaries. We show that the pipe flow becomes linearly unstable beyond a critical value (Wic≃5 ) of the Weissenberg number, via a supercritical bifurcation which results in a helical distortion of the extrudate. We find that the amplitude of the undulation vanishes as the aspect ratio L /R of the capillary tends to zero, and saturates for large L /R , indicating that the instability affects the whole pipe flow, rather than the contraction or exit regions. These results, when compared to previous theoretical and experimental works, lead us to argue that the nature of the instability is controlled by the level of shear thinning of the fluids. In addition, we provide strong hints that the nonlinear development of the instabiilty is mitigated, in our system, by the gradual emergence of gross wall slip.

Through a Glass Darkly: Glimpses into the Future of Mass Spectrometry

PubMed Central

Cooks, R. Graham; Mueller, Thomas

2013-01-01

The paper has three parts, (i) a brief overview of the main achievements made using mass spectrometry across all the fields of science, (ii) a survey of some of the topics currently being pursued most activity, including both applications and fundamental studies, and (iii) some hints as to what the future of mass spectrometry might hold with particular emphasis on revolutionary changes in the subject. Emphasis is given to ambient methods of ionization and their use in disease diagnosis and to their use in combination with miniature mass spectrometers for in-situ measurements. Special attention goes to the chemical aspects of mass spectrometry, including its emerging role as a preparative method based on accelerated bimolecular reaction rates in solution and on ion soft landing as a means of surface tailoring. In summary, the paper covers the proud history, vibrant present and expansive future of mass spectrometry. PMID:24349920

Hints from Run 1 and prospects from Run 2 at ATLAS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernius, Catrin, E-mail: Catrin.Bernius@cern.ch

2016-06-21

The Large Hadron Collider at CERN has allowed the ATLAS experiment to collect a large amount of proton-proton collision data at 7 TeV and 8 TeV centre-of-mass energies throughout Run 1. This dataset was used to discover a Higgs boson with Standard Model-like properties at a mass of about 125 GeV. Furthermore, an impressive number of searches for deviations from the Standard Model expectations have been carried out. To date, no evidence for new physics beyond the SM has been found. However, a few hints in form of 2-3 σ deviations have been observed. After an 18-month shutdown, in whichmore » the ATLAS detector has undergone various upgrades, the LHC has again started to deliver collision data at an increased centre-of-mass energy of 13 TeV, providing a much improved sensitivity for various searches, in particular for high mass particles. Some representative hints at the LHC Run 1 are presented, a brief overview of ATLAS upgrades and prospects for SUSY searches with early Run 2 data are given.« less

$$L_\\mu - L_\\tau$$ theory of Higgs flavor violation and $$(g-2)_\\mu$$

DOE PAGES

Altmannshofer, Wolfgang; Carena, Marcela; Crivellin, Andreas

2016-11-01

Several experiments reported hints for the violation of lepton flavor or lepton flavor universality in processes involving muons. Most prominently, there is the hint for a nonzero rate of the flavor violating Higgs decay h→τμ at the LHC, as well as the hint for lepton flavor universality violation in rare B meson decays at the LHCb. In addition, also the long-standing discrepancy in the anomalous magnetic moment of the muon motivates new physics connected to muons. A symmetry which violates lepton flavor universality is Lμ-Lτ: the difference of muon number and tau number. We show that adding vectorlike fermions tomore » a Lμ-Lτ theory generates naturally an effect in the anomalous magnetic moment of the muon and h→τμ, while effects in other τ→μ transitions are systematically suppressed by symmetry arguments. We find that if Lμ-Lτ is gauged it is possible to also accommodate the discrepant b→sμμ data while predicting a τ→3μ and a modified h→μμ rate within reach of upcoming experiments.« less

Current Trends in Wireless Mesh Sensor Networks: A Review of Competing Approaches

PubMed Central

Rodenas-Herraiz, David; Garcia-Sanchez, Antonio-Javier; Garcia-Sanchez, Felipe; Garcia-Haro, Joan

2013-01-01

Finding a complete mesh-based solution for low-rate wireless personal area networks (LR-WPANs) is still an open issue. To cope with this concern, different competing approaches have emerged in the Wireless Mesh Sensor Networks (WMSNs) field in the last few years. They are usually supported by the IEEE 802.15.4 standard, the most commonly adopted LR-WPAN recommendation for point-to-point topologies. In this work, we review the most relevant and up-to-date WMSN solutions that extend the IEEE 802.15.4 standard to multi-hop mesh networks. To conduct this review, we start by identifying the most significant WMSN requirements (i.e., interoperability, robustness, scalability, mobility or energy-efficiency) that reveal the benefits and shortcomings of each proposal. Then, we re-examine thoroughly the group of proposals following different design guidelines which are usually considered by end-users and developers. Among all of the approaches reviewed, we highlight the IEEE 802.15.5 standard, a recent recommendation that, in its LR-WPAN version, fully satisfies the greatest number of WMSN requirements. As a result, IEEE 802.15.5 can be an appropriate solution for a wide-range of applications, unlike the majority of the remaining solutions reviewed, which are usually designed to solve particular problems, for instance in the home, building and industrial sectors. In this sense, a description of IEEE 802.15.5 is also included, paying special attention to its efficient energy-saving mechanisms. Finally, possible improvements of this recommendation are pointed out in order to offer hints for future research. PMID:23666128

Assessment of Department of Defense Basic Research

DTIC Science & Technology

2005-01-01

Sciences, the National Academy of Engineering, the Institute of Medicine, and the National Research Council: • Download hundreds of free books in PDF...with our innovative research tools Thank you for downloading this free PDF. If you have comments, questions or just want more information... downloaded from: http://www.nap.edu/catalog/11177.html Assessment of Department of Defense Basic Research Committee on Department of Defense Basic

Privacy as Part of the App Decision-Making Process

DTIC Science & Technology

2013-02-06

concerns they may not actively consider privacy while downloading apps from smartphone application marketplaces. Currently Android users have only the... Android permissions display which appears after they have selected an app to download to help them understand how applications access their information...marketplaces. Currently, Android users have only the Android permissions display, which appears after they have selected an app to download, to help

A comparison of basic and social cognition between schizophrenia and schizoaffective disorder.

PubMed

Fiszdon, Joanna M; Richardson, Randall; Greig, Tamasine; Bell, Morris D

2007-03-01

We compared basic and social cognition in individuals with schizophrenia and schizoaffective disorder. 199 individuals with schizophrenia and 73 with schizoaffective disorder were compared on measures of executive function, verbal and nonverbal memory, and processing speed, as well as two measures of social cognition, the Hinting Task and the Bell Lysaker Emotion Recognition Task. The samples did not differ significantly on the basic cognitive measures, however individuals with schizoaffective disorder performed significantly better than those with schizophrenia on the Hinting Task, a measure of Theory of Mind. Results provide limited support for a taxonomic distinction between the two disorders.

Masking Release for Igbo and English.

PubMed

Ebem, Deborah U; Desloge, Joseph G; Reed, Charlotte M; Braida, Louis D; Uguru, Joy O

2013-09-01

In this research, we explored the effect of noise interruption rate on speech intelligibility. Specifically, we used the Hearing In Noise Test (HINT) procedure with the original HINT stimuli (English) and Igbo stimuli to assess speech reception ability in interrupted noise. For a given noise level, the HINT test provides an estimate of the signal-to-noise ratio (SNR) required for 50%-correct speech intelligibility. The SNR for 50%-correct intelligibility changes depending upon the interruption rate of the noise. This phenomenon (called Masking Release) has been studied extensively in English but not for Igbo - which is an African tonal language spoken predominantly in South Eastern Nigeria. This experiment explored and compared the phenomenon of Masking Release for (i) native English speakers listening to English, (ii) native Igbo speakers listening to English, and (iii) native Igbo speakers listening to Igbo. Since Igbo is a tonal language and English is a non-tonal language, this allowed us to compare Masking Release patterns on native speakers of tonal and non-tonal languages. Our results for native English speakers listening to English HINT show that the SNR and the masking release are orderly and consistent with other English HINT data for English speakers. Our result for Igbo speakers listening to English HINT sentences show that there is greater variability in results across the different Igbo listeners than across the English listeners. This result likely reflects different levels of ability in the English language across the Igbo listeners. The masking release values in dB are less than for English listeners. Our results for Igbo speakers listening to Igbo show that in general, the SNRs for Igbo sentences are lower than for English/English and Igbo/English. This means that the Igbo listeners could understand 50% of the Igbo sentences at SNRs less than those required for English sentences by either native or non-native listeners. This result can be explained by the fact that the perception of Igbo utterances by Igbo subjects may have been aided by the prediction of tonal and vowel harmony features existent in the Igbo language. In agreement with other studies, our results also show that in a noisy environment listeners are able to perceive their native language better than a second language. The ability of native language speakers to perceive their language better than a second language in a noisy environment may be attributed to the fact that: Native speakers are more familiar with the sounds of their language than second language speakers.One of the features of language is that it is predictable hence even in noise a native speaker may be able to predict a succeeding word that is scarcely audible. These contextual effects are facilitated by familiarity.

Relating Diseases by Integrating Gene Associations and Information Flow through Protein Interaction Network

PubMed Central

Hamaneh, Mehdi Bagheri; Yu, Yi-Kuo

2014-01-01

Identifying similar diseases could potentially provide deeper understanding of their underlying causes, and may even hint at possible treatments. For this purpose, it is necessary to have a similarity measure that reflects the underpinning molecular interactions and biological pathways. We have thus devised a network-based measure that can partially fulfill this goal. Our method assigns weights to all proteins (and consequently their encoding genes) by using information flow from a disease to the protein interaction network and back. Similarity between two diseases is then defined as the cosine of the angle between their corresponding weight vectors. The proposed method also provides a way to suggest disease-pathway associations by using the weights assigned to the genes to perform enrichment analysis for each disease. By calculating pairwise similarities between 2534 diseases, we show that our disease similarity measure is strongly correlated with the probability of finding the diseases in the same disease family and, more importantly, sharing biological pathways. We have also compared our results to those of MimMiner, a text-mining method that assigns pairwise similarity scores to diseases. We find the results of the two methods to be complementary. It is also shown that clustering diseases based on their similarities and performing enrichment analysis for the cluster centers significantly increases the term association rate, suggesting that the cluster centers are better representatives for biological pathways than the diseases themselves. This lends support to the view that our similarity measure is a good indicator of relatedness of biological processes involved in causing the diseases. Although not needed for understanding this paper, the raw results are available for download for further study at ftp://ftp.ncbi.nlm.nih.gov/pub/qmbpmn/DiseaseRelations/. PMID:25360770

IFEQ, app developed based on the J-SHIS system

NASA Astrophysics Data System (ADS)

Azuma, H.; Hao, K. X.; Fujiwara, H.

2015-12-01

Raise an awareness of earthquake disaster prevention is an important issue in Japan. To do that, we have developed an app IFEQ on smartphone based on the APIs provided by the J-SHIS that is an integrated system of Seismic Hazard Assessment. IFEQ can simulate a real situation of earthquake disaster you might experience at current spot. The hint of the IFEQ came from a question "What should I do IF a big EarthQuake hit now?" An earthquake risk situation is estimated by a location information that is acquired from GPS, the detail comprehensive information of a 250m mesh obtained through J-SHIS APIs by the geomorphological classification and a probability of intensity 6 lower (JMA) within 30 years. A user's photo was displayed with a risk situation surrounded by simply one touch. IFEQ helps oneself to overcome a gap between exist scenes and a horrible disaster by enhancing imagination. The results show people have more ideas to handle with the risk situation after using the App IFEQ. IFEQ App's features are summarized as below: 1. Visualizing an image photo with possible risks from a coming earthquake at present spot. 2. Displaying an exceedance probability within 30-years and a maximum seismic intensity within 10,000-years on present location. 3. User can obtain some advices of how to prepare for possible risks. 4. A risk with five ranks is given, especially for items of Building Collapse, Liquefaction and Landslide. IFEQ can be downloaded freely from http://www.j-shis.bosai.go.jp/app-ifearthquake J-SHIS APIs can be obtained from http://www.j-shis.bosai.go.jp/en/category/opencat/api

Volumes and bulk densities of forty asteroids from ADAM shape modeling

NASA Astrophysics Data System (ADS)

Hanuš, J.; Viikinkoski, M.; Marchis, F.; Ďurech, J.; Kaasalainen, M.; Delbo', M.; Herald, D.; Frappa, E.; Hayamizu, T.; Kerr, S.; Preston, S.; Timerson, B.; Dunham, D.; Talbot, J.

2017-05-01

Context. Disk-integrated photometric data of asteroids do not contain accurate information on shape details or size scale. Additional data such as disk-resolved images or stellar occultation measurements further constrain asteroid shapes and allow size estimates. Aims: We aim to use all the available disk-resolved images of approximately forty asteroids obtained by the Near-InfraRed Camera (Nirc2) mounted on the W.M. Keck II telescope together with the disk-integrated photometry and stellar occultation measurements to determine their volumes. We can then use the volume, in combination with the known mass, to derive the bulk density. Methods: We downloaded and processed all the asteroid disk-resolved images obtained by the Nirc2 that are available in the Keck Observatory Archive (KOA). We combined optical disk-integrated data and stellar occultation profiles with the disk-resolved images and use the All-Data Asteroid Modeling (ADAM) algorithm for the shape and size modeling. Our approach provides constraints on the expected uncertainty in the volume and size as well. Results: We present shape models and volume for 41 asteroids. For 35 of these asteroids, the knowledge of their mass estimates from the literature allowed us to derive their bulk densities. We see a clear trend of lower bulk densities for primitive objects (C-complex) and higher bulk densities for S-complex asteroids. The range of densities in the X-complex is large, suggesting various compositions. We also identified a few objects with rather peculiar bulk densities, which is likely a hint of their poor mass estimates. Asteroid masses determined from the Gaia astrometric observations should further refine most of the density estimates.

Relating diseases by integrating gene associations and information flow through protein interaction network.

PubMed

Hamaneh, Mehdi Bagheri; Yu, Yi-Kuo

2014-01-01

Identifying similar diseases could potentially provide deeper understanding of their underlying causes, and may even hint at possible treatments. For this purpose, it is necessary to have a similarity measure that reflects the underpinning molecular interactions and biological pathways. We have thus devised a network-based measure that can partially fulfill this goal. Our method assigns weights to all proteins (and consequently their encoding genes) by using information flow from a disease to the protein interaction network and back. Similarity between two diseases is then defined as the cosine of the angle between their corresponding weight vectors. The proposed method also provides a way to suggest disease-pathway associations by using the weights assigned to the genes to perform enrichment analysis for each disease. By calculating pairwise similarities between 2534 diseases, we show that our disease similarity measure is strongly correlated with the probability of finding the diseases in the same disease family and, more importantly, sharing biological pathways. We have also compared our results to those of MimMiner, a text-mining method that assigns pairwise similarity scores to diseases. We find the results of the two methods to be complementary. It is also shown that clustering diseases based on their similarities and performing enrichment analysis for the cluster centers significantly increases the term association rate, suggesting that the cluster centers are better representatives for biological pathways than the diseases themselves. This lends support to the view that our similarity measure is a good indicator of relatedness of biological processes involved in causing the diseases. Although not needed for understanding this paper, the raw results are available for download for further study at ftp://ftp.ncbi.nlm.nih.gov/pub/qmbpmn/DiseaseRelations/.

Using the AIDA--www.2aida.org--diabetes simulator. Part 2: recommended training requirements for health-carers planning to teach with the software.

PubMed

Lehmann, Eldon D; Tatti, Patrizio

2002-01-01

The purpose of this article is to document some recommended training requirements for health-carers planning to teach using the AIDA interactive educational diabetes simulator. AIDA is a diabetes computer program that permits the interactive simulation of plasma insulin and blood glucose profiles for teaching, demonstration, and self-learning purposes. It has been made freely available, without charge, on the Internet as a noncommercial contribution to continuing diabetes education. Since its launch in 1996 over 200,000 visits have been logged at the AIDA Website--www.2aida.org--and over 40,000 copies of the AIDA program have been downloaded free-of-charge. This report describes various training requirements that are recommended for health-care professionals who are interested in teaching with the software. Intended goals of this article are to answer possible questions from teachers using the program, highlight some minimum recommended training requirements for the software, suggest some "hints and tips" for teaching ideas, explain the importance of performing more studies/trials with the program, overview randomised controlled trial usage of the software, and highlight the importance of obtaining feedback from lesson participants. The recommendations seem to be straightforward and should help in formalising training with the program, as well as in the development of a network of teachers "accredited" to give lessons using the software. This report, together with the previous article (Part 1, Diabetes Technol Ther 2002;4:401-414), highlights the utility of providing guidelines and suggesting recommended training requirements for health-carers planning to make use of educational medical/diabetes software.

EPA Enforcement and Compliance History Online

EPA Pesticide Factsheets

The Environmental Protection Agency's Enforcement and Compliance History Online (ECHO) website provides customizable and downloadable information about environmental inspections, violations, and enforcement actions for EPA-regulated facilities related to the Clean Air Act, Clean Water Act, Resource Conservation and Recovery Act, and Safe Drinking Water Act. These data are updated weekly as part of the ECHO data refresh, and ECHO offers many user-friendly options to explore data, including:? Facility Search: ECHO information is searchable by varied criteria, including location, facility type, and compliance status. Search results are customizable and downloadable.? Comparative Maps and State Dashboards: These tools offer aggregated information about facility compliance status, regulatory agency compliance monitoring, and enforcement activity at the national and state level.? Bulk Data Downloads: One of ECHO??s most popular features is the ability to work offline by downloading large data sets. Users can take advantage of the ECHO Exporter, which provides summary information about each facility in comma-separated values (csv) file format, or download data sets by program as zip files.

The Research and Implementation of Vehicle Bluetooth Hands-free Devices Key Parameters Downloading Algorithm

NASA Astrophysics Data System (ADS)

Zhang, Xiao-bo; Wang, Zhi-xue; Li, Jian-xin; Ma, Jian-hui; Li, Yang; Li, Yan-qiang

In order to facilitate Bluetooth function realization and information can be effectively tracked in the process of production, the vehicle Bluetooth hands-free devices need to download such key parameters as Bluetooth address, CVC license and base plate numbers, etc. Therefore, it is the aim to search simple and effective methods to download parameters for each vehicle Bluetooth hands-free device, and to control and record the use of parameters. In this paper, by means of Bluetooth Serial Peripheral Interface programmer device, the parallel port is switched to SPI. The first step is to download parameters is simulating SPI with the parallel port. To perform SPI function, operating the parallel port in accordance with the SPI timing. The next step is to achieve SPI data transceiver functions according to the programming parameters of options. Utilizing the new method, downloading parameters is fast and accurate. It fully meets vehicle Bluetooth hands-free devices production requirements. In the production line, it has played a large role.

Datacasting V3.0

NASA Technical Reports Server (NTRS)

Bingham, Andrew W.; McCleese, Sean W.; Deen, Robert G.; Chung, Nga T.; Stough, Timothy M.

2013-01-01

Datacasting V3.0 provides an RSSbased feed mechanism for publishing the availability of Earth science data records in real time. It also provides a utility for subscribing to these feeds and sifting through all the items in an automatic manner to identify and download the data records that are required for a specific application. Datacasting is a method by which multiple data providers can publish the availability of new Earth science data and users download those files that meet a predefined need; for example, to only download data files related to a specific earthquake or region on the globe. Datacasting is a server-client architecture. The server-side software is used by data providers to create and publish the metadata about recently available data according to the Datacasting RSS (Really Simple Syndication) specification. The client software subscribes to the Datacasting RSS and other RSS-based feeds. By configuring filters associated with feeds, data consumers can use the client to identify and automatically download files that meet a specific need. On the client side, a Datacasting feed reader monitors the server for new feeds. The feed reader will be tuned by the user, via a graphical user interface (GUI), to examine the content of the feeds and initiate a data pull after some criteria are satisfied. The criteria might be, for example, to download sea surface temperature data for a particular region that has cloud cover less than 50% and during daylight hours. After the granule is downloaded to the client, the user will have the ability to visualize the data in the GUI. Based on the popular concept of podcasting, which gives listeners the capability to download only those MP3 files that match their preference, Earth science Datacasting will give users a method to download only the Earth science data files that are required for a particular application.

Distributed Multi-interface Catalogue for Geospatial Data

NASA Astrophysics Data System (ADS)

Nativi, S.; Bigagli, L.; Mazzetti, P.; Mattia, U.; Boldrini, E.

2007-12-01

Several geosciences communities (e.g. atmospheric science, oceanography, hydrology) have developed tailored data and metadata models and service protocol specifications for enabling online data discovery, inventory, evaluation, access and download. These specifications are conceived either profiling geospatial information standards or extending the well-accepted geosciences data models and protocols in order to capture more semantics. These artifacts have generated a set of related catalog -and inventory services- characterizing different communities, initiatives and projects. In fact, these geospatial data catalogs are discovery and access systems that use metadata as the target for query on geospatial information. The indexed and searchable metadata provide a disciplined vocabulary against which intelligent geospatial search can be performed within or among communities. There exists a clear need to conceive and achieve solutions to implement interoperability among geosciences communities, in the context of the more general geospatial information interoperability framework. Such solutions should provide search and access capabilities across catalogs, inventory lists and their registered resources. Thus, the development of catalog clearinghouse solutions is a near-term challenge in support of fully functional and useful infrastructures for spatial data (e.g. INSPIRE, GMES, NSDI, GEOSS). This implies the implementation of components for query distribution and virtual resource aggregation. These solutions must implement distributed discovery functionalities in an heterogeneous environment, requiring metadata profiles harmonization as well as protocol adaptation and mediation. We present a catalog clearinghouse solution for the interoperability of several well-known cataloguing systems (e.g. OGC CSW, THREDDS catalog and data services). The solution implements consistent resource discovery and evaluation over a dynamic federation of several well-known cataloguing and inventory systems. Prominent features include: 1)Support to distributed queries over a hierarchical data model, supporting incremental queries (i.e. query over collections, to be subsequently refined) and opaque/translucent chaining; 2)Support to several client protocols, through a compound front-end interface module. This allows to accommodate a (growing) number of cataloguing standards, or profiles thereof, including the OGC CSW interface, ebRIM Application Profile (for Core ISO Metadata and other data models), and the ISO Application Profile. The presented catalog clearinghouse supports both the opaque and translucent pattern for service chaining. In fact, the clearinghouse catalog may be configured either to completely hide the underlying federated services or to provide clients with services information. In both cases, the clearinghouse solution presents a higher level interface (i.e. OGC CSW) which harmonizes multiple lower level services (e.g. OGC CSW, WMS and WCS, THREDDS, etc.), and handles all control and interaction with them. In the translucent case, client has the option to directly access the lower level services (e.g. to improve performances). In the GEOSS context, the solution has been experimented both as a stand-alone user application and as a service framework. The first scenario allows a user to download a multi-platform client software and query a federation of cataloguing systems, that he can customize at will. The second scenario support server-side deployment and can be flexibly adapted to several use-cases, such as intranet proxy, catalog broker, etc.

A Feasibility Study on Using an Internet-Panel Survey to Measure Perceptions of E-cigarettes in 3 Metropolitan Areas, 2015.

PubMed

Miller, Eric A; Berman, Lewis; Atienza, Audie; Middleton, Deirdre; Iachan, Ronaldo; Tortora, Robert; Boyle, John

Internet-panel surveys are emerging as a means to quickly and cost-effectively collect health data, and because of their large memberships, they could be used for community-level surveys. To determine the feasibility of using an internet-panel survey to quickly provide community-level data, we conducted a pilot test of a health survey in 3 US metropolitan areas. We conducted internet-panel surveys in Cleveland, Ohio; New York, New York; and Seattle, Washington, in 2015. Slightly more than 500 people responded to the survey in each city. We compared weighted unadjusted prevalence estimates from the internet-panel data with estimates from the 2014 Health Information National Trends Survey (HINTS) for the following question in each survey: "Compared to smoking cigarettes, would you say that electronic cigarettes are…much less harmful, less harmful, just as harmful, more harmful, much more harmful, or I've never heard of electronic cigarettes." We used multivariable logistic regression to compare associations of respondents' demographic and health characteristics with perceived harm from e-cigarettes. The prevalence of the perception that e-cigarettes are less harmful than smoking cigarettes ranged from 35.9% to 39.9% in the internet-panel sites and was 43.0% in HINTS. Most patterns of beliefs and respondent characteristics in the internet-panel data were consistent with patterns in HINTS. We found inconsistent patterns between internet-panel sites and HINTS by race/ethnicity and education. This feasibility study found that internet-panel surveys could quickly produce community-level data for targeted public health interventions and evaluation, but they may be limited in producing estimates among subgroups.

Data Downloads | ECHO | US EPA

EPA Pesticide Factsheets

The ECHO website with its facility search features is designed to provide easy access to EPA's compliance and enforcement data with customizable onscreen display and download. For those with larger data needs, ECHO has several types of data sets available. These large data sets may be of particular use to developers, programmers, academics, and analysts. The data available here can be downloaded and used for many different functions and are certain to meet all data retrieval needs.

Ultrasound-Based Guidance for Partial Breast Irradiation Therapy

DTIC Science & Technology

2012-01-01

displace- 0278-0062/$20.00 © IEEE Authorized licensed use limited to: IEEE Xplore . Downloaded on January 5, 2009 at 17:37 from IEEE Xplore . Restrictions...Authorized licensed use limited to: IEEE Xplore . Downloaded on January 5, 2009 at 17:37 from IEEE Xplore . Restrictions apply. RIVAZ et al...better CNR values: the Authorized licensed use limited to: IEEE Xplore . Downloaded on January 5, 2009 at 17:37 from IEEE Xplore . Restrictions apply

Cordova: Web-based management of genetic variation data

PubMed Central

Ephraim, Sean S.; Anand, Nikhil; DeLuca, Adam P.; Taylor, Kyle R.; Kolbe, Diana L.; Simpson, Allen C.; Azaiez, Hela; Sloan, Christina M.; Shearer, A. Eliot; Hallier, Andrea R.; Casavant, Thomas L.; Scheetz, Todd E.; Smith, Richard J. H.; Braun, Terry A.

2014-01-01

Summary: Cordova is an out-of-the-box solution for building and maintaining an online database of genetic variations integrated with pathogenicity prediction results from popular algorithms. Our primary motivation for developing this system is to aid researchers and clinician–scientists in determining the clinical significance of genetic variations. To achieve this goal, Cordova provides an interface to review and manually or computationally curate genetic variation data as well as share it for clinical diagnostics and the advancement of research. Availability and implementation: Cordova is open source under the MIT license and is freely available for download at https://github.com/clcg/cordova. Contact: sean.ephraim@gmail.com or terry-braun@uiowa.edu PMID:25123904

The PLUTO code for astrophysical gasdynamics .

NASA Astrophysics Data System (ADS)

Mignone, A.

Present numerical codes appeal to a consolidated theory based on finite difference and Godunov-type schemes. In this context we have developed a versatile numerical code, PLUTO, suitable for the solution of high-mach number flow in 1, 2 and 3 spatial dimensions and different systems of coordinates. Different hydrodynamic modules and algorithms may be independently selected to properly describe Newtonian, relativistic, MHD, or relativistic MHD fluids. The modular structure exploits a general framework for integrating a system of conservation laws, built on modern Godunov-type shock-capturing schemes. The code is freely distributed under the GNU public license and it is available for download to the astrophysical community at the URL http://plutocode.to.astro.it.

3D reconstruction software comparison for short sequences

NASA Astrophysics Data System (ADS)

Strupczewski, Adam; Czupryński, BłaŻej

2014-11-01

Large scale multiview reconstruction is recently a very popular area of research. There are many open source tools that can be downloaded and run on a personal computer. However, there are few, if any, comparisons between all the available software in terms of accuracy on small datasets that a single user can create. The typical datasets for testing of the software are archeological sites or cities, comprising thousands of images. This paper presents a comparison of currently available open source multiview reconstruction software for small datasets. It also compares the open source solutions with a simple structure from motion pipeline developed by the authors from scratch with the use of OpenCV and Eigen libraries.

Development of 3D browsing and interactive web system

NASA Astrophysics Data System (ADS)

Shi, Xiaonan; Fu, Jian; Jin, Chaolin

2017-09-01

In the current market, users need to download specific software or plug-ins to browse the 3D model, and browsing the system may be unstable, and it cannot be 3D model interaction issues In order to solve this problem, this paper presents a solution to the interactive browsing of the model in the server-side parsing model, and when the system is applied, the user only needs to input the system URL and upload the 3D model file to operate the browsing The server real-time parsing 3D model, the interactive response speed, these completely follows the user to walk the minimalist idea, and solves the current market block 3D content development question.

EPA Regional KML Download

EPA Pesticide Factsheets

The EPA collects information about facilities or sites subject to environmental regulation. The EPA Geospatial Data Access Project provides downloadable files of these facilities or sites in KML format.

Third Structure Determination by Powder Diffractometery Round Robin (SDPDRR-3)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le Bail, A.; Cranswick, L; Adil, K

2009-01-01

The results from a third structure determination by powder diffractometry (SDPD) round robin are discussed. From the 175 potential participants having downloaded the powder data, nine sent a total of 12 solutions (8 and 4 for samples 1 and 2, respectively, a tetrahydrated calcium tartrate and a lanthanum tungstate). Participants used seven different computer programs for structure solution (ESPOIR, EXPO, FOX, PSSP, SHELXS, SUPERFLIP, and TOPAS), applying Patterson, direct methods, direct space methods, and charge flipping approach. It is concluded that solving a structure from powder data remains a challenge, at least one order of magnitude more difficult than solvingmore » a problem with similar complexity from single-crystal data. Nevertheless, a few more steps in the direction of increasing the SDPD rate of success were accomplished since the two previous round robins: this time, not only the computer program developers were successful but also some users. No result was obtained from crystal structure prediction experts.« less

An Innovative Solution to NASA's NEO Impact Threat Mitigation Grand Challenge and Flight Validation Mission Architecture Development

NASA Technical Reports Server (NTRS)

Wie, Bong; Barbee, Brent W.

2015-01-01

This paper presents the results of a NASA Innovative Advanced Concept (NIAC) Phase 2 study entitled "An Innovative Solution to NASA's Near-Earth Object (NEO) Impact Threat Mitigation Grand Challenge and Flight Validation Mission Architecture Development." This NIAC Phase 2 study was conducted at the Asteroid Deflection Research Center (ADRC) of Iowa State University in 2012-2014. The study objective was to develop an innovative yet practically implementable mitigation strategy for the most probable impact threat of an asteroid or comet with short warning time (< 5 years). The mitigation strategy described in this paper is intended to optimally reduce the severity and catastrophic damage of the NEO impact event, especially when we don't have sufficient warning times for non-disruptive deflection of a hazardous NEO. This paper provides an executive summary of the NIAC Phase 2 study results. Detailed technical descriptions of the study results are provided in a separate final technical report, which can be downloaded from the ADRC website (www.adrc.iastate.edu).

SfM with MRFs: discrete-continuous optimization for large-scale structure from motion.

PubMed

Crandall, David J; Owens, Andrew; Snavely, Noah; Huttenlocher, Daniel P

2013-12-01

Recent work in structure from motion (SfM) has built 3D models from large collections of images downloaded from the Internet. Many approaches to this problem use incremental algorithms that solve progressively larger bundle adjustment problems. These incremental techniques scale poorly as the image collection grows, and can suffer from drift or local minima. We present an alternative framework for SfM based on finding a coarse initial solution using hybrid discrete-continuous optimization and then improving that solution using bundle adjustment. The initial optimization step uses a discrete Markov random field (MRF) formulation, coupled with a continuous Levenberg-Marquardt refinement. The formulation naturally incorporates various sources of information about both the cameras and points, including noisy geotags and vanishing point (VP) estimates. We test our method on several large-scale photo collections, including one with measured camera positions, and show that it produces models that are similar to or better than those produced by incremental bundle adjustment, but more robustly and in a fraction of the time.

Design, challenge, and promise of stimuli-responsive nanoantibiotics

NASA Astrophysics Data System (ADS)

Edson, Julius A.; Kwon, Young Jik

2016-10-01

Over the past few years, there have been calls for novel antimicrobials to combat the rise of drug-resistant bacteria. While some promising new discoveries have met this call, it is not nearly enough. The major problem is that although these new promising antimicrobials serve as a short-term solution, they lack the potential to provide a long-term solution. The conventional method of creating new antibiotics relies heavily on the discovery of an antimicrobial compound from another microbe. This paradigm of development is flawed due to the fact that microbes can easily transfer a resistant mechanism if faced with an environmental pressure. Furthermore, there has been some evidence to indicate that the environment of the microbe can provide a hint as to their virulence. Because of this, the use of materials with antimicrobial properties has been garnering interest. Nanoantibiotics, (nAbts), provide a new way to circumvent the current paradigm of antimicrobial discovery and presents a novel mechanism of attack not found in microbes yet; which may lead to a longer-term solution against drug-resistance formation. This allows for environment-specific activation and efficacy of the nAbts but may also open up and create new design methods for various applications. These nAbts provide promise, but there is still ample work to be done in their development. This review looks at possible ways of improving and optimizing nAbts by making them stimuli-responsive, then consider the challenges ahead, and industrial applications.[Figure not available: see fulltext.

Calculation of unsteady airfoil loads with and without flap deflection at -90 degrees incidence

NASA Technical Reports Server (NTRS)

Stremel, Paul M.

1991-01-01

A method has been developed for calculating the viscous flow about airfoils with and without deflected flaps at -90 deg incidence. This unique method provides for the direct solution of the incompressible Navier-Stokes equations by means of a fully coupled implicit technique. The solution is calculated on a body-fitted computational mesh incorporating a staggered grid method. The vorticity is determined at the node points, and the velocity components are defined at the mesh-cell sides. The staggered-grid orientation provides for accurate representation of vorticity at the node points and for the conservation of mass at the mesh-cell centers. The method provides for the direct solution of the flow field and satisfies the conservation of mass to machine zero at each time-step. The results of the present analysis and experimental results obtained for a XV-15 airfoil are compared. The comparisons indicate that the calculated drag reduction caused by flap deflection and the calculated average surface pressure are in excellent agreement with the measured results. Comparisons of the numerical results of the present method for several airfoils demonstrate the significant influence of airfoil curvature and flap deflection on the predicted download.

Concurrent validity of the Harris Infant Neuromotor Test and the Alberta Infant Motor Scale.

PubMed

Tse, Lillian; Mayson, Tanja A; Leo, Sara; Lee, Leanna L S; Harris, Susan R; Hayes, Virginia E; Backman, Catherine L; Cameron, Dianne; Tardif, Megan

2008-02-01

We examined concurrent validity of scores for two infant motor screening tools, the Harris Infant Neuromotor Test (HINT) and the Alberta Infant Motor Scale, in 121 Canadian infants. Relationships between the two tests for the overall sample were as follows: r = -.83 at 4 to 6.5 months (n = 121; p < .01) and r = -.85 at 10 to 12.5 months (n = 109; p < .01), suggesting that the HINT, the newer of the two measures, is valid in determining motor delays. Each test has advantages and disadvantages, and practitioners should determine which one best meets their infant assessment needs.

Predicting speech intelligibility in noise for hearing-critical jobs

NASA Astrophysics Data System (ADS)

Soli, Sigfrid D.; Laroche, Chantal; Giguere, Christian

2003-10-01

Many jobs require auditory abilities such as speech communication, sound localization, and sound detection. An employee for whom these abilities are impaired may constitute a safety risk for himself or herself, for fellow workers, and possibly for the general public. A number of methods have been used to predict these abilities from diagnostic measures of hearing (e.g., the pure-tone audiogram); however, these methods have not proved to be sufficiently accurate for predicting performance in the noise environments where hearing-critical jobs are performed. We have taken an alternative and potentially more accurate approach. A direct measure of speech intelligibility in noise, the Hearing in Noise Test (HINT), is instead used to screen individuals. The screening criteria are validated by establishing the empirical relationship between the HINT score and the auditory abilities of the individual, as measured in laboratory recreations of real-world workplace noise environments. The psychometric properties of the HINT enable screening of individuals with an acceptable amount of error. In this presentation, we will describe the predictive model and report the results of field measurements and laboratory studies used to provide empirical validation of the model. [Work supported by Fisheries and Oceans Canada.

Hearing in Noise Test, HINT-Brazil, in normal-hearing children.

PubMed

Novelli, Carolina Lino; Carvalho, Nádia Giulian de; Colella-Santos, Maria Francisca

The auditory processing is related to certain skills such as speech recognition in noise. The HINT-Brazil test allows the measurement of the Speech/Noise ratio however there are no studies in the national literature that establish parameters for the child population. To analyze the performance of normal-hearing subjects aged 8-10 years old in tasks for speech recognition in noise using HINT test. Sixty schoolchildren were evaluated. They were between 8 and 10 years of age, of both genders, and had no auditory and school complaints, with results ranking within normality for the Basic Audiological Assessment and the Dichotic Digits Test. HINT-Brazil test was applied with headphones, with the Speech/Noise ratio in conditions of frontal noise, noise to the right, and noise to the left being investigated. The software calculated the Composite Noise, which corresponds to the weighted mean of the tested conditions. There was no statistically significant difference between the ears, nor between the genders. There was a statistically significant difference for age ranges of 8 and 10 years, in situations with noise, and for Composite Noise. The age group of 10 years showed better performance than the age group of 8; the age group of 9 years did not show statistically significant difference regarding the other age ranges. We suggest the values of mean and standard deviation of the Speech/Noise ratio, considering the age ranges of: 8 years - Frontal Noise: -2.09 (±1.09); Right Noise: -7.64 (±1.72); Left Noise: -7.53 (±2.80); Composite Noise: -4.86 (±1.31); 9 years - Frontal Noise: -2.82 (±0.74); Right Noise: -8.49 (±2.24); Left Noise: -8.41 (±1.75); Composite Noise: -5.63 (±1.02); 10 years - Frontal Noise: -3.01 (±0.95); Right Noise: -9.47 (±1.43); Left Noise: -9.16 (±1.65); Composite Noise: -6.16 (±0.91). HINT-Brazil test is a simple and fast test, and is not difficult to performed with normal-hearing children. The results confirm that it is an efficient test to be used with the age range evaluated. Copyright © 2017 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

Prescription Drugs

MedlinePlus

... View Online Download PDF Monitoring the Future 2017 Survey Results Published: December 12, 2017 This infographic of ... View Online Download PDF Monitoring the Future 2016 Survey Results Published: December 13, 2016 This infographic of ...

Staying Well

MedlinePlus

... Brochure Vitamins, Minerals, and Herbs in MS: An Introduction (.pdf) Practical guide to diet supplements for people ... you Vitamins, Minerals, and Herbs in MS: An Introduction (.pdf) Download Brochure Taming Stress (.pdf) Download Brochure ...

Towards the quantization of Eddington-inspired-Born-Infeld theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bouhmadi-López, Mariam; Chen, Che-Yu, E-mail: mbl@ubi.pt, E-mail: b97202056@gmail.com

2016-11-01

The quantum effects close to the classical big rip singularity within the Eddington-inspired-Born-Infeld theory (EiBI) are investigated through quantum geometrodynamics. It is the first time that this approach is applied to a modified theory constructed upon Palatini formalism. The Wheeler-DeWitt (WDW) equation is obtained and solved based on an alternative action proposed in ref. [1], under two different factor ordering choices. This action is dynamically equivalent to the original EiBI action while it is free of square root of the spacetime curvature. We consider a homogeneous, isotropic and spatially flat universe, which is assumed to be dominated by a phantommore » perfect fluid whose equation of state is a constant. We obtain exact solutions of the WDW equation based on some specific conditions. In more general cases, we propose a qualitative argument with the help of a Wentzel-Kramers-Brillouin (WKB) approximation to get further solutions. Besides, we also construct an effective WDW equation by simply promoting the classical Friedmann equations. We find that for all the approaches considered, the DeWitt condition hinting singularity avoidance is satisfied. Therefore the big rip singularity is expected to be avoided through the quantum approach within the EiBI theory.« less

Literature Review on Needs of Upper Limb Prosthesis Users.

PubMed

Cordella, Francesca; Ciancio, Anna Lisa; Sacchetti, Rinaldo; Davalli, Angelo; Cutti, Andrea Giovanni; Guglielmelli, Eugenio; Zollo, Loredana

2016-01-01

The loss of one hand can significantly affect the level of autonomy and the capability of performing daily living, working and social activities. The current prosthetic solutions contribute in a poor way to overcome these problems due to limitations in the interfaces adopted for controlling the prosthesis and to the lack of force or tactile feedback, thus limiting hand grasp capabilities. This paper presents a literature review on needs analysis of upper limb prosthesis users, and points out the main critical aspects of the current prosthetic solutions, in terms of users satisfaction and activities of daily living they would like to perform with the prosthetic device. The ultimate goal is to provide design inputs in the prosthetic field and, contemporary, increase user satisfaction rates and reduce device abandonment. A list of requirements for upper limb prostheses is proposed, grounded on the performed analysis on user needs. It wants to (i) provide guidelines for improving the level of acceptability and usefulness of the prosthesis, by accounting for hand functional and technical aspects; (ii) propose a control architecture of PNS-based prosthetic systems able to satisfy the analyzed user wishes; (iii) provide hints for improving the quality of the methods (e.g., questionnaires) adopted for understanding the user satisfaction with their prostheses.

Literature Review on Needs of Upper Limb Prosthesis Users

PubMed Central

Cordella, Francesca; Ciancio, Anna Lisa; Sacchetti, Rinaldo; Davalli, Angelo; Cutti, Andrea Giovanni; Guglielmelli, Eugenio; Zollo, Loredana

2016-01-01

The loss of one hand can significantly affect the level of autonomy and the capability of performing daily living, working and social activities. The current prosthetic solutions contribute in a poor way to overcome these problems due to limitations in the interfaces adopted for controlling the prosthesis and to the lack of force or tactile feedback, thus limiting hand grasp capabilities. This paper presents a literature review on needs analysis of upper limb prosthesis users, and points out the main critical aspects of the current prosthetic solutions, in terms of users satisfaction and activities of daily living they would like to perform with the prosthetic device. The ultimate goal is to provide design inputs in the prosthetic field and, contemporary, increase user satisfaction rates and reduce device abandonment. A list of requirements for upper limb prostheses is proposed, grounded on the performed analysis on user needs. It wants to (i) provide guidelines for improving the level of acceptability and usefulness of the prosthesis, by accounting for hand functional and technical aspects; (ii) propose a control architecture of PNS-based prosthetic systems able to satisfy the analyzed user wishes; (iii) provide hints for improving the quality of the methods (e.g., questionnaires) adopted for understanding the user satisfaction with their prostheses. PMID:27242413

Obstructive Sleep Apnea

MedlinePlus Videos and Cool Tools

... Apnea (OSA) Download Download the ebook for further information Obstructive sleep apnea (OSA) is a serious and ... that can create the necessary air passageway. The information provided here is not intended as a substitute ...

Administration of Anesthesia

MedlinePlus Videos and Cool Tools

... more. Anesthesia Download Download the ebook for further information Anesthesia: Safety and Comfort in the OMS Office ... comfortable as possible when you get home. The information provided here is not intended as a substitute ...

Health and Wellness

MedlinePlus

... Disease T Cells d What Causes MS? Disproved Theories Viruses Clusters d Who Gets MS? Pediatric MS ... Brochure Vitamins, Minerals, and Herbs in MS: An Introduction (.pdf) Download Brochure Taming Stress (.pdf) Download Brochure ...

Fine-Root Ecology Database (FRED): A Global Collection of Root Trait Data with Coincident Site, Vegetation, Edaphic, and Climatic Data, Version 2.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iversen, C.M.; Powell, A.S.; McCormack, M.L.

The second version of the Fine-Root Ecology Database is available for download! Download the full FRED 2.0 data set, user guidance document, map, and list of data sources here. Prior to downloading the data, please read and follow the Data Use Guidelines, and it's worth checking out some tips for using FRED before you begin your analyses. Also, see here for an updating list of corrections to FRED 2.0.

Analysis of United States’ Broadband Policy

DTIC Science & Technology

2007-03-01

compared with the minimum speed the FCC uses in its definition of broadband access. For example, using a 56K modem connection to download a 10...transmission rates multiple times faster than a 56K modem , users can view video or download software and other data-intensive files in a matter of seconds...boast download speeds from 144Kbps (roughly three times faster than a 56K dial-up modem connection) to 2.4Mbps (close to cable- modem speed). Although

Extension of a Computer Assisted Decision Support (CADS) Study to Improve Outcomes in Patients with Type 2 DM Treated by Primary Care Providers (short title, CADS-X). Addendum

DTIC Science & Technology

2014-12-01

Hypertension is one of the most common co-morbidities associated with DM and substantially contributes to the macrovascular disease that occurs in...After Numera terminated the contract to provide glucometer download support Estenda activated the patient portal , Diabetes Mellitus Everywhere...several patients. Problem areas include having to download JAVA with first upload and accessing the DME portal . d. PO has downloaded glucose

Algorithm design for automated transportation photo enforcement camera image and video quality diagnostic check modules

NASA Astrophysics Data System (ADS)

Raghavan, Ajay; Saha, Bhaskar

2013-03-01

Photo enforcement devices for traffic rules such as red lights, toll, stops, and speed limits are increasingly being deployed in cities and counties around the world to ensure smooth traffic flow and public safety. These are typically unattended fielded systems, and so it is important to periodically check them for potential image/video quality problems that might interfere with their intended functionality. There is interest in automating such checks to reduce the operational overhead and human error involved in manually checking large camera device fleets. Examples of problems affecting such camera devices include exposure issues, focus drifts, obstructions, misalignment, download errors, and motion blur. Furthermore, in some cases, in addition to the sub-algorithms for individual problems, one also has to carefully design the overall algorithm and logic to check for and accurately classifying these individual problems. Some of these issues can occur in tandem or have the potential to be confused for each other by automated algorithms. Examples include camera misalignment that can cause some scene elements to go out of focus for wide-area scenes or download errors that can be misinterpreted as an obstruction. Therefore, the sequence in which the sub-algorithms are utilized is also important. This paper presents an overview of these problems along with no-reference and reduced reference image and video quality solutions to detect and classify such faults.

Procurement of Shared Data Instruments for Research Electronic Data Capture (REDCap)

PubMed Central

Obeid, Jihad S; McGraw, Catherine A; Minor, Brenda L; Conde, José G; Pawluk, Robert; Lin, Michael; Wang, Janey; Banks, Sean R; Hemphill, Sheree A; Taylor, Rob; Harris, Paul A

2012-01-01

REDCap (Research Electronic Data Capture) is a web-based software solution and tool set that allows biomedical researchers to create secure online forms for data capture, management and analysis with minimal effort and training. The Shared Data Instrument Library (SDIL) is a relatively new component of REDCap that allows sharing of commonly used data collection instruments for immediate study use by 3 research teams. Objectives of the SDIL project include: 1) facilitating reuse of data dictionaries and reducing duplication of effort; 2) promoting the use of validated data collection instruments, data standards and best practices; and 3) promoting research collaboration and data sharing. Instruments submitted to the library are reviewed by a library oversight committee, with rotating membership from multiple institutions, which ensures quality, relevance and legality of shared instruments. The design allows researchers to download the instruments in a consumable electronic format in the REDCap environment. At the time of this writing, the SDIL contains over 128 data collection instruments. Over 2500 instances of instruments have been downloaded by researchers at multiple institutions. In this paper we describe the library platform, provide detail about experience gained during the first 25 months of sharing public domain instruments and provide evidence of impact for the SDIL across the REDCap consortium research community. We postulate that the shared library of instruments reduces the burden of adhering to sound data collection principles while promoting best practices. PMID:23149159

PPIS Download Product Information Data

EPA Pesticide Factsheets

Downloadable Pesticide Product Information System data for Federal Insecticide Fungicide and Rodenticide Act section 3 and section 24(c) (Special Local Need), vocabulary, and U.S. companies and organizations with EPA Company Numbers.

Corrective Jaw Surgery

MedlinePlus Videos and Cool Tools

... Jaw Surgery Download Download the ebook for further information Corrective jaw, or orthognathic surgery is performed by ... your treatment. Correction of Common Dentofacial Deformities ​ ​ The information provided here is not intended as a substitute ...

Head, Neck, and Oral Cancer

MedlinePlus Videos and Cool Tools

... Neck Pathology Download Download the ebook for further information Your oral and maxillofacial surgeon (OMS) is the ... well be the key to complete recovery. The information provided here is not intended as a substitute ...

Facts and Stats - Hydrocephalus Association

MedlinePlus

... this in Theme Options SIGN IN File Download Verification Thank you for downloading our publication! We will ... I am ...: Child Friend Grandchild Grandparent Medical Professional Self Sibling Parent Spouse Other Patient Diagnosed Age: Infants ( ...

Downloading and Installing Estuary Data Mapper (EDM)

EPA Pesticide Factsheets

Estuary Data Mapper is a tool for geospatial data discovery, visualization, and data download for any of the approximately 2,000 estuaries and associated watersheds in along the five US coastal regions

Depression and College Students

MedlinePlus

... depression and other mental health issues? Reference Share Depression and College Students Download PDF Download ePub Order ... Answers to college students’ frequently asked questions about depression Feeling moody, sad, or grouchy? Who doesn’t ...

Biblio-Link and Pro-Cite: The Searcher's Workstation.

ERIC Educational Resources Information Center

Hoyle, Norman; McNamara, Kathleen

1987-01-01

Describes the Biblio-Link and Pro-Cite software packages, which can be used together to create local databases with downloaded records, or to reorganize and repackage downloaded records for client reports. (CLB)

Civil Penalty Policies

EPA Pesticide Factsheets

The Environmental Protection Agency's Enforcement and Compliance History Online (ECHO) website provides customizable and downloadable information about environmental inspections, violations, and enforcement actions for EPA-regulated facilities, like power plants and factories. ECHO advances public information by sharing data related to facility compliance with and regulatory agency activity related to air, hazardous waste, clean water, and drinking water regulations. ECHO offers many user-friendly options to explore data, including:1. Facility Search (http://echo.epa.gov/facilities/facility-search?mediaSelected=all): ECHO information is searchable by varied criteria, including location, facility type, and compliance status related to the Clean Air Act, Clean Water Act, Resource Conservation and Recovery Act, and Safe Drinking Water Act. Search results are customizable and downloadable.2. Comparative Maps (http://echo.epa.gov/maps/state-comparative-maps) and State Dashboards (http://echo.epa.gov/trends/comparative-maps-dashboards/state-air-dashboard): These tools offer aggregated information about facility compliance status and regulatory agency compliance monitoring and enforcement activity at the national and state level.3. Bulk Data Downloads (http://echo.epa.gov/resources/echo-data/data-downloads): One of ECHO's most popular features is the ability to work offline by downloading large data sets. Users can take advantage of the ECHO Exporter, which provides su

Cough and Cold Medicine (DXM and Codeine Syrup)

MedlinePlus

... View Online Download PDF Monitoring the Future 2017 Survey Results Published: December 12, 2017 This infographic of ... View Online Download PDF Monitoring the Future 2016 Survey Results Published: December 13, 2016 This infographic of ...

SEER*Explorer

Cancer.gov

This interactive website provides access to cancer statistics (rates and trends) for a cancer site by gender, race, calendar year, stage, and histology. Users can create custom graphs and tables, download data and images, download SEER*Stat sessions, and share results.

5 Things You Should Know about Stress

MedlinePlus

... Information Share 5 Things You Should Know About Stress Download PDF Download ePub Order a free hardcopy ... five things you should know about stress: 1. Stress affects everyone. Everyone feels stressed from time to ...

DefenseLink Special: Doolittle Raid, April 18, 1942

Science.gov Websites

enhanced viewing {Flash 8} Macromedia Flash Player 8 required Download free Macromedia Flash Player Download free Internet Explorer DOOLITTLE RAIDERS – Retired Lt. Col. Chase Nelson, a Doolittle Raider

7 CFR 318.13-14 - Movement of processed fruits, vegetables, and other products.

Code of Federal Regulations, 2010 CFR

2010-01-01

.../import_export/plants/manuals/ports/downloads/hawaii.pdf and http://www.aphis.usda.gov/import_export/plants/manuals/ports/downloads/puerto_rico.pdf. (b) Consignments of processed fruits, vegetables, or...

The Teen Brain: 6 Things to Know

MedlinePlus

... adults For More Information Reprints Share The Teen Brain: 6 Things to Know Download PDF Download ePub ... big and important changes are happening to the brain during adolescence? Here are 6 things to know ...

Novel Low Cost High Efficiency Tunable RF Devices and Antenna Arrays Design based on the Ferroelectric Materials and the CTS Technologies

DTIC Science & Technology

2011-02-14

licensed use limited to: UNIV OF HAWAII LIBRARY. Downloaded on June 18,2010 at 22:24:49 UTC from IEEE Xplore . Restrictions apply. KIM et al.: MODIFIED...limited to: UNIV OF HAWAII LIBRARY. Downloaded on June 18,2010 at 22:24:49 UTC from IEEE Xplore . Restrictions apply. 404 IEEE TRANSACTIONS ON...licensed use limited to: UNIV OF HAWAII LIBRARY. Downloaded on June 18,2010 at 22:24:49 UTC from IEEE Xplore . Restrictions apply. KIM et al

Data::Downloader

NASA Technical Reports Server (NTRS)

Duggan, Brian

2012-01-01

Downloading and organizing large amounts of files is challenging, and often done using ad hoc methods. This software is capable of downloading and organizing files as an OpenSearch client. It can subscribe to RSS (Really Simple Syndication) feeds and Atom feeds containing arbitrary metadata, and maintains a local content addressable data store. It uses existing standards for obtaining the files, and uses efficient techniques for storing the files. Novel features include symbolic links to maintain a sane directory structure, checksums for validating file integrity during transfer and storage, and flexible use of server-provided metadata.

Cordova: web-based management of genetic variation data.

PubMed

Ephraim, Sean S; Anand, Nikhil; DeLuca, Adam P; Taylor, Kyle R; Kolbe, Diana L; Simpson, Allen C; Azaiez, Hela; Sloan, Christina M; Shearer, A Eliot; Hallier, Andrea R; Casavant, Thomas L; Scheetz, Todd E; Smith, Richard J H; Braun, Terry A

2014-12-01

Cordova is an out-of-the-box solution for building and maintaining an online database of genetic variations integrated with pathogenicity prediction results from popular algorithms. Our primary motivation for developing this system is to aid researchers and clinician-scientists in determining the clinical significance of genetic variations. To achieve this goal, Cordova provides an interface to review and manually or computationally curate genetic variation data as well as share it for clinical diagnostics and the advancement of research. Cordova is open source under the MIT license and is freely available for download at https://github.com/clcg/cordova. Published by Oxford University Press. This work is written by US Government employees and is in the public domain in the US.

A General Provincial Situation Visualization System Based on iPhone Operating System of Shandong Province

NASA Astrophysics Data System (ADS)

Ye, Z.; Xiang, H.

2014-04-01

The paper discusses the basic principles and the problem solutions during the design and implementation of the mobile GIS system, and base on the research result, we developed the General Provincial Situation Visualization System Based on iOS of Shandong Province. The system is developed in the Objective-C programming language, and use the ArcGIS Runtime SDK for IOS as the development tool to call the "World-map Shandong" services to implement the development of the General Provincial Situation Visualization System Based on iOS devices. The system is currently available for download in the Appstore and is chosen as the typical application case of ESRI China ArcGIS API for iOS.

Digital Tidbits

ERIC Educational Resources Information Center

Kumaran, Maha; Geary, Joe

2011-01-01

Technology has transformed libraries. There are digital libraries, electronic collections, online databases and catalogs, ebooks, downloadable books, and much more. With free technology such as social websites, newspaper collections, downloadable online calendars, clocks and sticky notes, online scheduling, online document sharing, and online…

37 CFR 385.10 - General.

Code of Federal Regulations, 2014 CFR

2014-07-01

....10 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS RATES AND TERMS... AND DISTRIBUTING OF PHYSICAL AND DIGITAL PHONORECORDS Interactive Streaming and Limited Downloads... interactive streams and limited downloads of musical works by subscription and nonsubscription digital music...

Publications - PR 121 | Alaska Division of Geological & Geophysical Surveys

Science.gov Websites

: Download below or please see our publication sales page for more information. Quadrangle(s): Philip Smith Philip Smith Mountains: Surficial Geology Data File Format File Size Info Download psm-surficial-geo

Stellar recipes for axion hunters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giannotti, Maurizio; Irastorza, Igor G.; Redondo, Javier

There are a number of observational hints from astrophysics which point to the existence of stellar energy losses beyond the ones accounted for by neutrino emission. These excessive energy losses may be explained by the existence of a new sub-keV mass pseudoscalar Nambu-Goldstone boson with tiny couplings to photons, electrons, and nucleons. An attractive possibility is to identify this particle with the axion—the hypothetical pseudo Nambu-Goldstone boson predicted by the Peccei-Quinn solution to the strong CP problem. We explore this possibility in terms of a DFSZ-type axion and of a KSVZ-type axion/majoron, respectively. Both models allow a good global fitmore » to the data, prefering an axion mass around 10 meV. We show that future axion experiments—the fifth force experiment ARIADNE and the helioscope IAXO—can attack the preferred mass range from the lower and higher end, respectively. An axion in this mass range can also be the main constituent of dark matter.« less

Using a student-faculty collaborative learning model to teach grant development in graduate nursing education.

PubMed

Falk, Nancy L; Phillips, Kathleen M; Hymer, Regina; Acquaviva, Kimberly D; Schumann, Mary Jean

2014-05-01

Graduate nurses are employed in clinical, research, educational, and policy roles. As leaders, they are expected to develop and sustain projects that support translating research to practice and policy. Funding to support initiatives is tight and requires innovative solutions to cover salaries, benefits, equipment purchases, and other program expenses. In an effort to teach grant writing while developing skilled leaders who are effective and competitive in securing funds, the George Washington University School of Nursing offers a graduate-level grant writing course. In the summer of 2011, a collaborative learning model was developed within the course. The joint approach was foundational to securing an Agency for Healthcare Research and Quality grant to support development and implementation of a patient engagement project by the Nursing Alliance for Quality Care. This article describes the project and offers hints for those seeking to develop a collaborative educational experience that affords new leadership skills for RNs from all backgrounds. Copyright 2014, SLACK Incorporated.

Binding CO2 from Air by a Bulky Organometallic Cation Containing Primary Amines.

PubMed

Luo, Yang-Hui; Chen, Chen; Hong, Dan-Li; He, Xiao-Tong; Wang, Jing-Wen; Ding, Ting; Wang, Bo-Jun; Sun, Bai-Wang

2018-03-21

The organometallic cation 1 (Fe(bipy-NH 2 ) 3 2+ , bipy-NH 2 = 4,4'-diamino-2,2'-bipyridine), which was constructed in situ in solution, can bind CO 2 from air effectively with a stoichiometric ratio of 1:4 (1/CO 2 ), through the formation of "H-bonded CO 2 " species: [CO 2 -OH-CO 2 ] - and [CO 2 -CO 2 -OH] - . These two species, along with the captured individual CO 2 molecules, connected 1 into a novel 3D (three-dimensional) architecture, that was crystal 1·2(OH - )·4(CO 2 ). The adsorption isotherms, recycling investigations, and the heat capacity of 1 have been investigated; the results revealed that the organometallic cation 1 can be recycled at least 10 times for the real-world CO 2 capture applications. The strategies presented here may provide new hints for the development of new alkanolamine-related absorbents or technologies for CO 2 capture and sequestration.

Working with Enzymes - Where Is Lactose Digested? An Enzyme Assay for Nutritional Biochemistry Laboratories

NASA Astrophysics Data System (ADS)

Pope, Sandi R.; Tolleson, Tonya D.; Williams, R. Jill; Underhill, Russell D.; Deal, S. Todd

1998-06-01

At Georgia Southern University, we offer a sophomore-level introductory biochemistry course that is aimed at nutrition and chemistry education majors. The laboratory portion of this course has long lacked an experimental introduction to enzymes. We have developed a simple enzyme assay utilizing lactase enzyme from crushed LactAid tablets and a 5% lactose solution ("synthetic milk"). In the experiment, the students assay the activity of the enzyme on the "synthetic milk" at pHs of approximately 1, 6, and 8 with the stated goal of determining where lactose functions in the digestive tract. The activity of the lactase may be followed chromatographically or spectrophotometrically. The experiment, which is actually a simple pH assay, is easily implemented in allied health chemistry laboratory courses and readily lends itself to adaptation for more complex kinetic assays in upper-level biochemistry laboratory courses. The experimental details, including a list of required supplies and hints for implementation, are provided.

The effect of cesium carbonate on 1-(3-methoxycarbonyl)propyl-1-phenyl[6,6]C{sub 61} aggregation in films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lindemann, William R.; Wang, Wenjie; Shinar, Joseph

2014-11-10

Surface-pressure versus molecular area isotherms, X-ray reflectivity, and X-ray near-total reflection fluorescence were used to study the properties of 1-(3-methoxycarbonyl)propyl-1-phenyl[6,6]C{sub 61} (PCBM) that was pre-mixed with cesium carbonate and spread as a film at the air-water interface. The pre-mixed PCBM with cesium carbonate demonstrated a strikingly strong effect on the organization of the film. Whereas films formed from pure PCBM solution were rough due to strong inter-molecular interactions, the films formed from the mixture were much smoother. This indicates that the cesium carbonate moderates the inter-molecular interactions among PCBM molecules, hinting that the cesium diffusion observed in inverted organic photovoltaicmore » structures and the likely ensuing ionic Cs-PCBM interaction decrease aggregation tendency of PCBM. This implies that the use of cesium salts affects the morphology of the organic layer and consequently improves the efficiency of these devices.« less

The effect of cesium carbonate on 1-(3-methoxycarbonyl)propyl-1-phenyl[6,6]C 61 aggregation in films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lindemann, William R.; Wang, Wenjie; Fungura, Fadzai

2014-11-11

Surface-pressure isotherms, X-ray reflectivity, and X-ray near-total reflection fluorescence were used to study the properties of 1-(3-methoxycarbonyl)propyl-1-phenyl[6,6]C 61 (PCBM) that was pre-mixed with cesium carbonate and spread as a film at the air-water interface. The pre-mixed PCBM with cesium carbonate demonstrated a strikingly strong effect on the organization of the film. Whereas films formed from pure PCBM solution were rough due to strong inter-molecular interactions, the films formed from the mixture were much smoother. This indicates that the cesium carbonate moderates the inter-molecular interactions among PCBM molecules, hinting that the cesium diffusion observed in inverted organic photovoltaics and the likelymore » ensuing ionic Cs-PCBM interaction decrease aggregation tendency of PCBM. As a result, this implies that the use of cesium salts affects the morphology of the organic layer and consequently improves the efficiency of these devices.« less

Tuning optical properties of water-soluble CdTe quantum dots for biological applications

NASA Astrophysics Data System (ADS)

Schulze, Anne S.; Tavernaro, Isabella; Machka, Friederike; Dakischew, Olga; Lips, Katrin S.; Wickleder, Mathias S.

2017-02-01

In this study, two different synthetic methods in aqueous solution are presented to tune the optical properties of CdTe and CdSe semiconductor nanoparticles. Additionally, the influence of different temperatures, pressures, precursor ratios, surface ligands, bases, and core components in the synthesis was investigated with regard to the particle sizes and optical properties. As a result, a red shift of the emission and absorption maxima with increasing reaction temperature (100 to 220°C), pressure (1 to 25 bar), and different ratios of core components of alloyed semiconductor nanoparticles could be observed without a change of the particle size. An increase in particle size from 2.5 to 5 nm was only achieved by variation of the mercaptocarboxylic acid ligands in combination with the reaction time and used base. To get a first hint on the cytotoxic effects and cell uptake of the synthesized quantum dots, in vitro tests mesenchymal stem cells (MSCs) were carried out.

[Dépistage précoce des retards du développement moteur: Outil de dépistage axé sur la famille].

PubMed

Harris, Susan R

2016-08-01

Décrire le test HINT (Harris Infant Neuromotor Test), un test d'évaluation du développement neuromoteur chez les nourrissons publié en 2010, qui s'appuie sur les normes canadiennes et peut être utilisé pour dépister les retards du développement moteur durant la première année de la vie. QUALITÉ DES DONNÉES: D'abondantes recherches ont été publiées sur la fiabilité intra-évaluateur, inter-évaluateur et test-retest ainsi que sur la validité convergente, prédictive, du contenu et des groupes connus du test HINT, de même que sur la sensibilité, la spécificité et les valeurs prédictives négatives et positives des inquiétudes des parents, telles qu'évaluées par le test HINT. La plupart des données probantes sont de niveau II. Il est important de diagnostiquer les retards du développement moteur durant la première année de vie, car ils sont souvent le signe de retards du développement généralisés ou de déficiences précises, telles que la paralysie cérébrale. Les inquiétudes des parents quant au développement moteur de leur enfant sont une valeur prédictive robuste de diagnostics subséquents de retard du développement moteur. Seul le dépistage précoce des retards du développement moteur, initialement par l'entremise d'outils de dépistage comme le test HINT, permet de recommander le patient à une intervention précoce qui profiterait tant à l'enfant qu'à sa famille. Copyright© the College of Family Physicians of Canada.

Dépistage précoce des retards du développement moteur

PubMed Central

Harris, Susan R.

2016-01-01

Résumé Objectif Décrire le test HINT (Harris Infant Neuromotor Test), un test d’évaluation du développement neuromoteur chez les nourrissons publié en 2010, qui s’appuie sur les normes canadiennes et peut être utilisé pour dépister les retards du développement moteur durant la première année de la vie. Qualité des données D’abondantes recherches ont été publiées sur la fiabilité intra-évaluateur, inter-évaluateur et test-retest ainsi que sur la validité convergente, prédictive, du contenu et des groupes connus du test HINT, de même que sur la sensibilité, la spécificité et les valeurs prédictives négatives et positives des inquiétudes des parents, telles qu’évaluées par le test HINT. La plupart des données probantes sont de niveau II. Message principal Il est important de diagnostiquer les retards du développement moteur durant la première année de vie, car ils sont souvent le signe de retards du développement généralisés ou de déficiences précises, telles que la paralysie cérébrale. Les inquiétudes des parents quant au développement moteur de leur enfant sont une valeur prédictive robuste de diagnostics subséquents de retard du développement moteur. Conclusion Seul le dépistage précoce des retards du développement moteur, initialement par l’entremise d’outils de dépistage comme le test HINT, permet de recommander le patient à une intervention précoce qui profiterait tant à l’enfant qu’à sa famille. PMID:27521405

Validating an electronic health literacy scale in an older hispanic population.

PubMed

Aponte, Judith; Nokes, Kathleen M

2017-09-01

To examine the validity of the Spanish version of an instrument used to measure electronic health literacy (eHEALS) with an older Hispanic population from a number of Spanish-language countries living in New York City in the United States (US). Although the Internet is available globally, complex skills are needed to use this source of valuable health-related information effectively. Electronic health literacy is a multifactorial concept that includes health literacy but also requires technology skills. Cross-sectional. Recruitment occurred at a Senior Organization located in a largely Hispanic neighbourhood in New York City (N = 100). Participants completed eHEALS and selected items from the Health Information National Trends Survey (HINTS) which assesses how adults use different communication channels, including the Internet, to obtain vital health information. Data from the US HINTS sample (N = 162) were matched to the Senior Organization sample on age range and Hispanic ethnicity. The average Senior Organization participant was 68 years old, female, born in one of six different Spanish-language countries, and completed high school while the average HINTS participant was 67 years old, female and had high school or less education. Although there was no relationship with the two HINTS subscales and electronic health literacy, there were significant relationships between electronic health literacy and health status and confidence in self-care. Inadequate electronic health literacy is a barrier to positive health outcomes. The Spanish version of eHEALS could be used as a screening instrument to identify gaps and tailored interventions could be developed to increase consumer confidence in using the Internet for reliable health-related information. Knowledge in self-management is related to positive health outcomes; all persons irrespective of their electronic health literacy should be able to use all sources of health information to enhance their self-care. © 2017 John Wiley & Sons Ltd.

Open access publishing, article downloads, and citations: randomised controlled trial

PubMed Central

Lewenstein, Bruce V; Simon, Daniel H; Booth, James G; Connolly, Mathew J L

2008-01-01

Objective To measure the effect of free access to the scientific literature on article downloads and citations. Design Randomised controlled trial. Setting 11 journals published by the American Physiological Society. Participants 1619 research articles and reviews. Main outcome measures Article readership (measured as downloads of full text, PDFs, and abstracts) and number of unique visitors (internet protocol addresses). Citations to articles were gathered from the Institute for Scientific Information after one year. Interventions Random assignment on online publication of articles published in 11 scientific journals to open access (treatment) or subscription access (control). Results Articles assigned to open access were associated with 89% more full text downloads (95% confidence interval 76% to 103%), 42% more PDF downloads (32% to 52%), and 23% more unique visitors (16% to 30%), but 24% fewer abstract downloads (−29% to −19%) than subscription access articles in the first six months after publication. Open access articles were no more likely to be cited than subscription access articles in the first year after publication. Fifty nine per cent of open access articles (146 of 247) were cited nine to 12 months after publication compared with 63% (859 of 1372) of subscription access articles. Logistic and negative binomial regression analysis of article citation counts confirmed no citation advantage for open access articles. Conclusions Open access publishing may reach more readers than subscription access publishing. No evidence was found of a citation advantage for open access articles in the first year after publication. The citation advantage from open access reported widely in the literature may be an artefact of other causes. PMID:18669565

30-36 Months: Your Child's Development

MedlinePlus

... Resources & Services Parenting Resource 30–36 Months: Your Child’s Development Download Files Feb 10, 2016 Older toddlers are ... go?” Then you two can switch. Downloads Your Child's Development: 30–36 Months PDF 373 KB Read more ...

12-15 Months: Your Child's Development

MedlinePlus

... Resources & Services Parenting Resource 12–15 Months: Your Child’s Development Download Files Feb 9, 2016 This is a ... who she is. Downloads 12–15 Months: Your Child’s Development PDF 418 KB Read more about: Ages and ...

Generalized Anxiety Disorder: When Worry Gets Out of Control

MedlinePlus

... of Control Download PDF Download ePub Order a free hardcopy What Is GAD? Occasional anxiety is a normal part of life. You might worry about things like health, money, or family problems. But people with generalized anxiety ...

Tutorial for the structure elucidation of small molecules by means of the LSD software.

PubMed

Nuzillard, Jean-Marc; Plainchont, Bertrand

2018-06-01

Automatic structure elucidation of small molecules by means of the "logic for structure elucidation" (LSD) software is introduced in the context of the automatic exploitation of chemical shift correlation data and with minimal input from chemical shift values. The first step in solving a structural problem by means of LSD is the extraction of pertinent data from the 1D and 2D spectra. This operation requires the labeling of the resonances and of their correlations; its reliability highly depends on the quality of the spectra. The combination of COSY, HSQC, and HMBC spectra results in proximity relationships between nonhydrogen atoms that are associated in order to build the possible solutions of a problem. A simple molecule, camphor, serves as an example for the writing of an LSD input file and to show how solution structures are obtained. An input file for LSD must contain a nonambiguous description of each atom, or atom status, which includes the chemical element symbol, the hybridization state, the number of bound hydrogen atoms and the formal electric charge. In case of atom status ambiguity, the pyLSD program performs clarification by systematically generating the status of the atoms. PyLSD also proposes the use of the nmrshiftdb algorithm in order to rank the solutions of a problem according to the quality of the fit between the experimental carbon-13 chemical shifts, and the ones predicted from the proposed structures. To conclude, some hints toward future uses and developments of computer-assisted structure elucidation by LSD are proposed. Copyright © 2017 John Wiley & Sons, Ltd.

Can chaos be observed in quantum gravity?

NASA Astrophysics Data System (ADS)

Dittrich, Bianca; Höhn, Philipp A.; Koslowski, Tim A.; Nelson, Mike I.

2017-06-01

Full general relativity is almost certainly 'chaotic'. We argue that this entails a notion of non-integrability: a generic general relativistic model, at least when coupled to cosmologically interesting matter, likely possesses neither differentiable Dirac observables nor a reduced phase space. It follows that the standard notion of observable has to be extended to include non-differentiable or even discontinuous generalized observables. These cannot carry Poisson-algebraic structures and do not admit a standard quantization; one thus faces a quantum representation problem of gravitational observables. This has deep consequences for a quantum theory of gravity, which we investigate in a simple model for a system with Hamiltonian constraint that fails to be completely integrable. We show that basing the quantization on standard topology precludes a semiclassical limit and can even prohibit any solutions to the quantum constraints. Our proposed solution to this problem is to refine topology such that a complete set of Dirac observables becomes continuous. In the toy model, it turns out that a refinement to a polymer-type topology, as e.g. used in loop gravity, is sufficient. Basing quantization of the toy model on this finer topology, we find a complete set of quantum Dirac observables and a suitable semiclassical limit. This strategy is applicable to realistic candidate theories of quantum gravity and thereby suggests a solution to a long-standing problem which implies ramifications for the very concept of quantization. Our work reveals a qualitatively novel facet of chaos in physics and opens up a new avenue of research on chaos in gravity which hints at deep insights into the structure of quantum gravity.

Binaural Interference and the Effects of Age and Hearing Loss.

PubMed

Mussoi, Bruna S S; Bentler, Ruth A

2017-01-01

The existence of binaural interference, defined here as poorer speech recognition with both ears than with the better ear alone, is well documented. Studies have suggested that its prevalence may be higher in the elderly population. However, no study to date has explored binaural interference in groups of younger and older adults in conditions that favor binaural processing (i.e., in spatially separated noise). Also, the effects of hearing loss have not been studied. To examine binaural interference through speech perception tests, in groups of younger adults with normal hearing, older adults with normal hearing for their age, and older adults with hearing loss. A cross-sectional study. Thirty-three participants with symmetric thresholds were recruited from the University of Iowa community. Participants were grouped as follows: younger with normal hearing (18-28 yr, n = 12), older with normal hearing for their age (73-87 yr, n = 9), and older with hearing loss (78-94 yr, n = 12). Prior noise exposure was ruled out. The Connected Speech Test (CST) and Hearing in Noise Test (HINT) were administered to all participants bilaterally, and to each ear separately. Test materials were presented in the sound field with speech at 0° azimuth and the noise at 180°. The Dichotic Digits Test (DDT) was administered to all participants through earphones. Hearing aids were not used during testing. Group results were compared with repeated measures and one-way analysis of variances, as appropriate. Within-subject analyses using pre-established critical differences for each test were also performed. The HINT revealed no effect of condition (individual ear versus bilateral presentation) using group analysis, although within-subject analysis showed that 27% of the participants had binaural interference (18% had binaural advantage). On the CST, there was significant binaural advantage across all groups with group data analysis, as well as for 12% of the participants at each of the two signal-to-babble ratios (SBRs) tested. One participant had binaural interference at each SBR. Finally, on the DDT, a significant right-ear advantage was found with group data, and for at least some participants. Regarding age effects, more participants in the pooled elderly groups had binaural interference (33.3%) than in the younger group (16.7%), on the HINT. The presence of hearing loss yielded overall lower scores, but none of the comparisons between bilateral and unilateral performance were affected by hearing loss. Results of within-subject analyses on the HINT agree with previous findings of binaural interference in ≥17% of listeners. Across all groups, a significant right-ear advantage was also seen on the DDT. HINT results support the notion that the prevalence of binaural interference is likely higher in the elderly population. Hearing loss, however, did not affect the differences between bilateral and better unilateral scores. The possibility of binaural interference should be considered when fitting hearing aids to listeners with symmetric hearing loss. Comparing bilateral to unilateral (unaided) performance on tests such as the HINT may provide the clinician with objective data to support subjective preference for one hearing aid as opposed to two. American Academy of Audiology

Full-text, Downloading, & Other Issues.

ERIC Educational Resources Information Center

Tenopir, Carol

1983-01-01

Issues having a possible impact on online search services in libraries are discussed including full text databases, front-end processors which translate user's input into the command language of an appropriate system, downloading to create personal files from commercial databases, and pricing. (EJS)

37 CFR 385.21 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 385.21 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS RATES AND... MAKING AND DISTRIBUTING OF PHYSICAL AND DIGITAL PHONORECORDS Limited Offerings, Mixed Service Bundles..., permanent digital downloads, restricted downloads or ringtones; (3) In the case of a music bundle, the...

Delay Differential Equation-Based Modeling of Passively Mode-Locked Quantum Dot Lasers Using Measured Gain and Loss Spectra (Postprint)

DTIC Science & Technology

2013-01-01

semiconductor laser8, 9: ATAe d dA TQiTGi qg 12 11 2 1 (1) 2 0 1 AeeGgd dG GQ (2) Proc. of SPIE Vol. 8255 82551K-2 Downloaded From: http...1 Downloaded From: http://spiedigitallibrary.org/ on 01/14/2013 Terms of Use: http://spiedl.org/terms 1 Approved for public release; distribution...parameters ( 0g and 0q , respectively) have been derived to yield: Gg0 (10) Proc. of SPIE Vol. 8255 82551K-3 Downloaded From: http

Clean Air Status and Trends Network (CASTNET) Download Data Module

EPA Pesticide Factsheets

The CASTNET Download Data module allows users to select, view, and download CASTNET data (Raw, Aggregate, Modeled & Factual Data) based on user selections. CASTNET sites are located in or near rural areas and sensitive ecosystems collecting data on ambient levels of pollutants where urban influences are minimal. CASTNET, which was initiated in 1986, is able to provide data needed to assess and report on geographic patterns and long-term temporal trends in ambient air pollution and dry atmospheric deposition. CASTNET can also be used to track changes in measurements associated with climate change (such as temperature and precipitation).

A Cooperative Downloading Method for VANET Using Distributed Fountain Code.

PubMed

Liu, Jianhang; Zhang, Wenbin; Wang, Qi; Li, Shibao; Chen, Haihua; Cui, Xuerong; Sun, Yi

2016-10-12

Cooperative downloading is one of the effective methods to improve the amount of downloaded data in vehicular ad hoc networking (VANET). However, the poor channel quality and short encounter time bring about a high packet loss rate, which decreases transmission efficiency and fails to satisfy the requirement of high quality of service (QoS) for some applications. Digital fountain code (DFC) can be utilized in the field of wireless communication to increase transmission efficiency. For cooperative forwarding, however, processing delay from frequent coding and decoding as well as single feedback mechanism using DFC cannot adapt to the environment of VANET. In this paper, a cooperative downloading method for VANET using concatenated DFC is proposed to solve the problems above. The source vehicle and cooperative vehicles encodes the raw data using hierarchical fountain code before they send to the client directly or indirectly. Although some packets may be lost, the client can recover the raw data, so long as it receives enough encoded packets. The method avoids data retransmission due to packet loss. Furthermore, the concatenated feedback mechanism in the method reduces the transmission delay effectively. Simulation results indicate the benefits of the proposed scheme in terms of increasing amount of downloaded data and data receiving rate.

eCOMPAGT – efficient Combination and Management of Phenotypes and Genotypes for Genetic Epidemiology

PubMed Central

Schönherr, Sebastian; Weißensteiner, Hansi; Coassin, Stefan; Specht, Günther; Kronenberg, Florian; Brandstätter, Anita

2009-01-01

Background High-throughput genotyping and phenotyping projects of large epidemiological study populations require sophisticated laboratory information management systems. Most epidemiological studies include subject-related personal information, which needs to be handled with care by following data privacy protection guidelines. In addition, genotyping core facilities handling cooperative projects require a straightforward solution to monitor the status and financial resources of the different projects. Description We developed a database system for an efficient combination and management of phenotypes and genotypes (eCOMPAGT) deriving from genetic epidemiological studies. eCOMPAGT securely stores and manages genotype and phenotype data and enables different user modes with different rights. Special attention was drawn on the import of data deriving from TaqMan and SNPlex genotyping assays. However, the database solution is adjustable to other genotyping systems by programming additional interfaces. Further important features are the scalability of the database and an export interface to statistical software. Conclusion eCOMPAGT can store, administer and connect phenotype data with all kinds of genotype data and is available as a downloadable version at . PMID:19432954

Automated realtime data import for the i2b2 clinical data warehouse: introducing the HL7 ETL cell.

PubMed

Majeed, Raphael W; Röhrig, Rainer

2012-01-01

Clinical data warehouses are used to consolidate all available clinical data from one or multiple organizations. They represent an important source for clinical research, quality management and controlling. Since its introduction, the data warehouse i2b2 gathered a large user base in the research community. Yet, little work has been done on the process of importing clinical data into data warehouses using existing standards. In this article, we present a novel approach of utilizing the clinical integration server as data source, commonly available in most hospitals. As information is transmitted through the integration server, the standardized HL7 message is immediately parsed and inserted into the data warehouse. Evaluation of import speeds suggest feasibility of the provided solution for real-time processing of HL7 messages. By using the presented approach of standardized data import, i2b2 can be used as a plug and play data warehouse, without the hurdle of customized import for every clinical information system or electronic medical record. The provided solution is available for download at http://sourceforge.net/projects/histream/.

Icy Hydra

NASA Image and Video Library

2016-05-06

The surface of Hydra, Pluto outermost small moon, is dominated by nearly pristine water ice confirming hints that scientists picked up in NASA New Horizons images showing Hydra highly reflective surface.

Integration of EGA secure data access into Galaxy.

PubMed

Hoogstrate, Youri; Zhang, Chao; Senf, Alexander; Bijlard, Jochem; Hiltemann, Saskia; van Enckevort, David; Repo, Susanna; Heringa, Jaap; Jenster, Guido; J A Fijneman, Remond; Boiten, Jan-Willem; A Meijer, Gerrit; Stubbs, Andrew; Rambla, Jordi; Spalding, Dylan; Abeln, Sanne

2016-01-01

High-throughput molecular profiling techniques are routinely generating vast amounts of data for translational medicine studies. Secure access controlled systems are needed to manage, store, transfer and distribute these data due to its personally identifiable nature. The European Genome-phenome Archive (EGA) was created to facilitate access and management to long-term archival of bio-molecular data. Each data provider is responsible for ensuring a Data Access Committee is in place to grant access to data stored in the EGA. Moreover, the transfer of data during upload and download is encrypted. ELIXIR, a European research infrastructure for life-science data, initiated a project (2016 Human Data Implementation Study) to understand and document the ELIXIR requirements for secure management of controlled-access data. As part of this project, a full ecosystem was designed to connect archived raw experimental molecular profiling data with interpreted data and the computational workflows, using the CTMM Translational Research IT (CTMM-TraIT) infrastructure http://www.ctmm-trait.nl as an example. Here we present the first outcomes of this project, a framework to enable the download of EGA data to a Galaxy server in a secure way. Galaxy provides an intuitive user interface for molecular biologists and bioinformaticians to run and design data analysis workflows. More specifically, we developed a tool -- ega_download_streamer - that can download data securely from EGA into a Galaxy server, which can subsequently be further processed. This tool will allow a user within the browser to run an entire analysis containing sensitive data from EGA, and to make this analysis available for other researchers in a reproducible manner, as shown with a proof of concept study.  The tool ega_download_streamer is available in the Galaxy tool shed: https://toolshed.g2.bx.psu.edu/view/yhoogstrate/ega_download_streamer.

Integration of EGA secure data access into Galaxy

PubMed Central

Hoogstrate, Youri; Zhang, Chao; Senf, Alexander; Bijlard, Jochem; Hiltemann, Saskia; van Enckevort, David; Repo, Susanna; Heringa, Jaap; Jenster, Guido; Fijneman, Remond J.A.; Boiten, Jan-Willem; A. Meijer, Gerrit; Stubbs, Andrew; Rambla, Jordi; Spalding, Dylan; Abeln, Sanne

2016-01-01

High-throughput molecular profiling techniques are routinely generating vast amounts of data for translational medicine studies. Secure access controlled systems are needed to manage, store, transfer and distribute these data due to its personally identifiable nature. The European Genome-phenome Archive (EGA) was created to facilitate access and management to long-term archival of bio-molecular data. Each data provider is responsible for ensuring a Data Access Committee is in place to grant access to data stored in the EGA. Moreover, the transfer of data during upload and download is encrypted. ELIXIR, a European research infrastructure for life-science data, initiated a project (2016 Human Data Implementation Study) to understand and document the ELIXIR requirements for secure management of controlled-access data. As part of this project, a full ecosystem was designed to connect archived raw experimental molecular profiling data with interpreted data and the computational workflows, using the CTMM Translational Research IT (CTMM-TraIT) infrastructure http://www.ctmm-trait.nl as an example. Here we present the first outcomes of this project, a framework to enable the download of EGA data to a Galaxy server in a secure way. Galaxy provides an intuitive user interface for molecular biologists and bioinformaticians to run and design data analysis workflows. More specifically, we developed a tool -- ega_download_streamer - that can download data securely from EGA into a Galaxy server, which can subsequently be further processed. This tool will allow a user within the browser to run an entire analysis containing sensitive data from EGA, and to make this analysis available for other researchers in a reproducible manner, as shown with a proof of concept study.  The tool ega_download_streamer is available in the Galaxy tool shed: https://toolshed.g2.bx.psu.edu/view/yhoogstrate/ega_download_streamer. PMID:28232859

Pulse phase-coherent timing and spectroscopy of CXOU J164710.2-45521 outbursts

NASA Astrophysics Data System (ADS)

Rodríguez Castillo, Guillermo A.; Israel, Gian Luca; Esposito, Paolo; Pons, José A.; Rea, Nanda; Turolla, Roberto; Viganò, Daniele; Zane, Silvia

2014-06-01

We present a long-term phase-coherent timing analysis and pulse-phase resolved spectroscopy for the two outbursts observed from the transient anomalous X-ray pulsar CXOU J164710.2-455216. For the first outburst we used 11 Chandra and XMM-Newton observations between 2006 September and 2009 August, the longest baseline yet for this source. We obtain a coherent timing solution with P = 10.61065583(4) s, Ṗ = 9.72(1) × 10-13 s s-1 and P̈ = -1.05(5) × 10-20 s s-2. Under the standard assumptions this implies a surface dipolar magnetic field of ˜1014 G, confirming this source as a standard B magnetar. We also study the evolution of the pulse profile (shape, intensity and pulsed fraction) as a function of time and energy. Using the phase-coherent timing solution we perform a phase-resolved spectroscopy analysis, following the spectral evolution of pulse-phase features, which hints at the physical processes taking place on the star. The results are discussed from the perspective of magnetothermal evolution models and the untwisting magnetosphere model. Finally, we present similar analysis for the second, less intense, 2011 outburst. For the timing analysis we used Swift data together with 2 XMM-Newton and Chandra pointings. The results inferred for both outbursts are compared and briefly discussed in a more general framework.

What is general relativity?

NASA Astrophysics Data System (ADS)

Coley, Alan A.; Wiltshire, David L.

2017-05-01

General relativity is a set of physical and geometric principles, which lead to a set of (Einstein) field equations that determine the gravitational field and to the geodesic equations that describe light propagation and the motion of particles on the background. But open questions remain, including: what is the scale on which matter and geometry are dynamically coupled in the Einstein equations? Are the field equations valid on small and large scales? What is the largest scale on which matter can be coarse grained while following a geodesic of a solution to Einstein’s equations? We address these questions. If the field equations are causal evolution equations, whose average on cosmological scales is not an exact solution of the Einstein equations, then some simplifying physical principle is required to explain the statistical homogeneity of the late epoch Universe. Such a principle may have its origin in the dynamical coupling between matter and geometry at the quantum level in the early Universe. This possibility is hinted at by diverse approaches to quantum gravity which find a dynamical reduction to two effective dimensions at high energies on one hand, and by cosmological observations which are beginning to strongly restrict the class of viable inflationary phenomenologies on the other. We suggest that the foundational principles of general relativity will play a central role in reformulating the theory of spacetime structure to meet the challenges of cosmology in the 21st century.

A possible solution to the B → π π puzzle using the principle of maximum conformality

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qiao, Cong -Feng; Zhu, Rui -Lin; Wu, Xing

2015-07-22

We measured the B d→π 0π 0B d→π 0π 0 branching fraction and found that it deviates significantly from conventional QCD predictions, a puzzle which has persisted for more than 10 years. This may be a hint of new physics beyond the Standard Model; however, as we shall show in this paper, the pQCD prediction is highly sensitive to the choice of the renormalization scales which enter the decay amplitude. In the present paper, we show that the renormalization scale uncertainties for B→ππB→ππ can be greatly reduced by applying the Principle of Maximum Conformality (PMC), and more precise predictions formore » CP-averaged branching ratios B(B→ππ)B(B→ππ) can be achieved. Combining the errors in quadrature, we obtain View the MathML sourceB(Bd→π 0π 0)|PMC=(0.98 -0.31 +0.44)×10 -6 by using the light-front holographic low-energy model for the running coupling. All of the CP-averaged B→ππB→ππ branching fractions predicted by the PMC are consistent with the Particle Data Group average values and the recent Belle data. Moreover, the PMC provides a possible solution for the B d→π 0π 0B d→π 0π 0 puzzle.« less

An experimental and analytical method for approximate determination of the tilt rotor research aircraft rotor/wing download

NASA Technical Reports Server (NTRS)

Jordon, D. E.; Patterson, W.; Sandlin, D. R.

1985-01-01

The XV-15 Tilt Rotor Research Aircraft download phenomenon was analyzed. This phenomenon is a direct result of the two rotor wakes impinging on the wing upper surface when the aircraft is in the hover configuration. For this study the analysis proceeded along tow lines. First was a method whereby results from actual hover tests of the XV-15 aircraft were combined with drag coefficient results from wind tunnel tests of a wing that was representative of the aircraft wing. Second, an analytical method was used that modeled that airflow caused gy the two rotors. Formulas were developed in such a way that acomputer program could be used to calculate the axial velocities were then used in conjunction with the aforementioned wind tunnel drag coefficinet results to produce download values. An attempt was made to validate the analytical results by modeling a model rotor system for which direct download values were determinrd..

Measuring metrics - a 40-year longitudinal cross-validation of citations, downloads, and peer review in astrophysics

NASA Astrophysics Data System (ADS)

Kurtz, Michael J.; Henneken, Edwin A.

2017-03-01

Citation measures, and newer altmetric measures such as downloads are now commonly used to inform personnel decisions. How well do or can these measures measure or predict the past, current, or future scholarly performance of an individual? Using data from the Smithsonian/NASA Astrophysics Data System we analyze the publication, citation, download, and distinction histories of a cohort of 922 individuals who received a U.S. PhD in astronomy in the period 1972-1976. By examining the same and different measures at the same and different times for the same individuals we are able to show the capabilities and limitations of each measure. Because the distributions are lognormal, measurement uncertainties are multiplicative; we show that in order to state with 95% confidence that one person's citations and downloads are significantly higher than another person's, the log difference in the ratio of counts must be at least 0.3dex, which corresponds to a multiplicative factor of 2.

Valuing geospatial information: Using the contingent valuation method to estimate the economic benefits of Landsat satellite imagery

USGS Publications Warehouse

Loomis, John; Koontz, Steve; Miller, Holly M.; Richardson, Leslie A.

2015-01-01

While the U.S. government does not charge for downloading Landsat images, the images have value to users. This paper demonstrates a method that can value Landsat and other imagery to users. A survey of downloaders of Landsat images found: (a) established US users have a mean value of $912 USD per scene; (b) new US users and users returning when imagery became free have a mean value of $367 USD per scene. Total US user benefits for the 2.38 million scenes downloaded is $1.8 billion USD. While these benefits indicate a high willingness-to-pay among many Landsat downloaders, it would be economically inefficient for the US government to charge for Landsat imagery. Charging a price of $100 USD a scene would result in an efficiency loss of $37.5 million a year. This economic information should be useful to policy-makers who must decide about the future of this and similar remote sensing programs.

A simple and fast heuristic for protein structure comparison

PubMed Central

Pelta, David A; González, Juan R; Moreno Vega, Marcos

2008-01-01

Background Protein structure comparison is a key problem in bioinformatics. There exist several methods for doing protein comparison, being the solution of the Maximum Contact Map Overlap problem (MAX-CMO) one of the alternatives available. Although this problem may be solved using exact algorithms, researchers require approximate algorithms that obtain good quality solutions using less computational resources than the formers. Results We propose a variable neighborhood search metaheuristic for solving MAX-CMO. We analyze this strategy in two aspects: 1) from an optimization point of view the strategy is tested on two different datasets, obtaining an error of 3.5%(over 2702 pairs) and 1.7% (over 161 pairs) with respect to optimal values; thus leading to high accurate solutions in a simpler and less expensive way than exact algorithms; 2) in terms of protein structure classification, we conduct experiments on three datasets and show that is feasible to detect structural similarities at SCOP's family and CATH's architecture levels using normalized overlap values. Some limitations and the role of normalization are outlined for doing classification at SCOP's fold level. Conclusion We designed, implemented and tested.a new tool for solving MAX-CMO, based on a well-known metaheuristic technique. The good balance between solution's quality and computational effort makes it a valuable tool. Moreover, to the best of our knowledge, this is the first time the MAX-CMO measure is tested at SCOP's fold and CATH's architecture levels with encouraging results. Software is available for download at . PMID:18366735

Development of Download System for Waveform Data Observed at Long-Term Borehole Monitoring System installed in the Nankai Trough

NASA Astrophysics Data System (ADS)

Tsuboi, Seiji; Horikawa, Hiroki; Takaesu, Morifumi; Sueki, Kentaro; Araki, Eiichiro; Sonoda, Akira; Takahashi, Narumi

2016-04-01

The Nankai Trough in southwest Japan is one of most active subduction zone in the world. Great mega-thrust earthquakes repeatedly occurred every 100 to 150 years in this area, it's anticipated to occur in the not distant future. For the purpose of elucidation of the history of mega-splay fault activity, the physical properties of the geological strata and the internal structure of the accretionary prism, and monitoring of diastrophism in this area, we have a plan, Nankai Trough Seismogenic Zone Experiments (NanTroSEIZE), as a part of Integrated Ocean Drilling Program (IODP). We have a plan to install the borehole observation system in a few locations by the NanTroSEIZE. This system is called Long-Term Borehole Monitoring System, it consists of various sensors in the borehole such as a broadband seismometer, a tiltmeter, a strainmeter, geophones and accelerometer, thermometer array as well as pressure ports for pore-fluid pressure monitoring. The signal from sensors is transmitted to DONET (Dense Ocean-floor Network System for Earthquake and Tsunamis) in real time. During IODP Exp. 332 in December 2010, the first Long-Term Borehole Monitoring System was installed into the C0002 borehole site located 80 km off the Kii Peninsula, 1938 m water depth in the Nankai Trough. We have developed a web application system for data download, Long-Term Borehole Monitoring Data Site. Based on a term and sensors which user selected on this site, user can download monitoring waveform data (e.g. broadband seismometer data, accelerometer data, strainmeter data, tiltmeter data) in near real-time. This system can make the arbitrary data which user selected a term and sensors, and download it simply. Downloadable continuous data is provided in seed format, which includes sensor informations. In addition, before data download, user can check that data is abailable or not by data check function. In this presentation, we show our web application system and discuss our future plans for developments of monitoring data download system.

The Effects of Digital Noise Reduction on the Acceptance of Background Noise

PubMed Central

Mueller, H. Gustav; Weber, Jennifer; Hornsby, Benjamin W. Y.

2006-01-01

Modern hearing aids commonly employ digital noise reduction (DNR) algorithms. The potential benefit of these algorithms is to provide improved speech understanding in noise or, at the least, to provide relaxed listening or increased ease of listening. In this study, 22 adults were fitted with 16-channel wide-dynamic-range compression hearing aids containing DNR processing. The DNR includes both modulation-based and Wiener-filter-type algorithms working simultaneously. Both speech intelligibility and acceptable noise level (ANL) were assessed using the Hearing in Noise Test (HINT) with DNR on and DNR off. The ANL was also assessed without hearing aids. The results showed a significant mean improvement for the ANL (4.2 dB) for the DNR-on condition when compared to DNR-off condition. Moreover, there was a significant correlation between the magnitude of ANL improvement (relative to DNR on) and the DNR-off ANL. There was no significant mean improvement for the HINT for the DNR-on condition, and on an individual basis, the HINT score did not significantly correlate with either aided ANL (DNR on or DNR off). These findings suggest that at least within the constraints of the DNR algorithms and test conditions employed in this study, DNR can significantly improve the clinically measured ANL, which may result in improved ease of listening for speech-in-noise situations. PMID:16959732

Different Facets of Body Image Disturbance in Binge Eating Disorder: A Review

PubMed Central

Lewer, Merle; Bauer, Anika

2017-01-01

The goal of the present review is to give an overview of the current findings on various facets of body image disturbance in Binge Eating Disorder such as body dissatisfaction, overconcern with weight and shape, body-related checking and avoidance behavior, misperception of body size, and body-related cognitive bias. In addition, treatments for a disturbed body image in BED and evidence of body image disturbance in youth with binge eating are reviewed. The results show that a disturbed body image in BED is present in the form of overconcern with weight and shape. Furthermore, there are hints that body dissatisfaction, as well as body-related checking and avoidance behavior, are also impaired. Research concerning misperception of body size in BED has been neglected so far, but first findings show that individuals with BED rate their own body shape rather accurately. Furthermore, there are first hints that body-related cognitive biases are present in individuals with BED. Moreover, in children and adolescents, there are first hints that body dissatisfaction, as well as shape and weight concerns, seem to be associated with loss of control and binge eating. Treatments aimed directly at the convertibility of a disturbed body image in BED have revealed encouraging outcomes. In conclusion, body image disturbance seems to occur in BED, and first studies show that it can be treated effectively. PMID:29182531

Results with cochlear implantation in adults with speech recognition scores exceeding current criteria.

PubMed

Amoodi, Hosam A; Mick, Paul T; Shipp, David B; Friesen, Lendra M; Nedzelski, Julian M; Chen, Joseph M; Lin, Vincent Y W

2012-01-01

The primary purpose of this study was to evaluate a group of postlingually deafened adults, whose aided speech recognition exceeded commonly accepted candidacy criteria for implantation. The study aimed to define performance and qualitative outcomes of cochlear implants in these individuals compared with their optimally fitted hearing aid(s). Retrospective case series. Tertiary referral center. All postlingually deafened subjects (N = 27), who were unsuccessful hearing aid users implanted between 2000 and 2010 with a preimplantation Hearing in Noise Test (HINT) score of 60% or more were included. We compared patients' preoperative performance (HINT score) with hearing aids to postoperative performance with the cochlear implant after 12 months of device use. In addition, the Hearing Handicap Inventory questionnaire was used to quantify the hearing-related handicap change perceived after the implantation. The study group demonstrated significant postoperative improvement on all outcome measures; most notably, the mean HINT score improved from 68.4% (standard deviation, 8.3) to 91.9% (standard deviation, 9.7). Additionally, there was a significant improvement in hearing-related handicap perceived by all patients. The envelope of implantation candidacy criteria continues to expand as shown by this study's cohort. Patient satisfaction and speech recognition results are very encouraging in support of treating those who currently perform at a level above the conventional candidacy threshold but struggle with optimally fitted hearing aids.

The GeoClaw software for depth-averaged flows with adaptive refinement

USGS Publications Warehouse

Berger, M.J.; George, D.L.; LeVeque, R.J.; Mandli, Kyle T.

2011-01-01

Many geophysical flow or wave propagation problems can be modeled with two-dimensional depth-averaged equations, of which the shallow water equations are the simplest example. We describe the GeoClaw software that has been designed to solve problems of this nature, consisting of open source Fortran programs together with Python tools for the user interface and flow visualization. This software uses high-resolution shock-capturing finite volume methods on logically rectangular grids, including latitude-longitude grids on the sphere. Dry states are handled automatically to model inundation. The code incorporates adaptive mesh refinement to allow the efficient solution of large-scale geophysical problems. Examples are given illustrating its use for modeling tsunamis and dam-break flooding problems. Documentation and download information is available at www.clawpack.org/geoclaw. ?? 2011.

A collection of problems for physics teaching

NASA Astrophysics Data System (ADS)

Gröber, S.; Jodl, H.-J.

2010-07-01

Problems are an important instrument for teachers to mediate physics content and for learners to adopt this content. This collection of problems is not only suited to traditional teaching and learning in lectures or student labs, but also to all kinds of new ways of teaching and learning, such as self-study, long-distance teaching, project-oriented learning and the use of remote labs/web experiments. We focus on Rutherford's scattering experiment, electron diffraction, Millikan's experiment and the use of pendulums to measure the dependence of gravitational acceleration on latitude. The collection contains about 50 problems with 160 subtasks and solutions, altogether 100 pages. Structure, content, range and the added value of the problems are described. The whole collection can be downloaded for free from http://rcl.physik.uni-kl.de.

The National Informal STEM Education Network

Science.gov Websites

Evaluation and Research Kits Explore Science: Earth & Space toolkit Building with Biology Kit Explore 2018 toolkits now available for download. Download the 2018 Digital Toolkit! Building with Biology ACTIVITY KIT Building with Biology Conversations and activities about synthetic biology; this emerging

Correcting Inconsistencies and Errors in Bacterial Genome Metadata Using an Automated Curation Tool in Excel (AutoCurE).

PubMed

Schmedes, Sarah E; King, Jonathan L; Budowle, Bruce

2015-01-01

Whole-genome data are invaluable for large-scale comparative genomic studies. Current sequencing technologies have made it feasible to sequence entire bacterial genomes with relative ease and time with a substantially reduced cost per nucleotide, hence cost per genome. More than 3,000 bacterial genomes have been sequenced and are available at the finished status. Publically available genomes can be readily downloaded; however, there are challenges to verify the specific supporting data contained within the download and to identify errors and inconsistencies that may be present within the organizational data content and metadata. AutoCurE, an automated tool for bacterial genome database curation in Excel, was developed to facilitate local database curation of supporting data that accompany downloaded genomes from the National Center for Biotechnology Information. AutoCurE provides an automated approach to curate local genomic databases by flagging inconsistencies or errors by comparing the downloaded supporting data to the genome reports to verify genome name, RefSeq accession numbers, the presence of archaea, BioProject/UIDs, and sequence file descriptions. Flags are generated for nine metadata fields if there are inconsistencies between the downloaded genomes and genomes reports and if erroneous or missing data are evident. AutoCurE is an easy-to-use tool for local database curation for large-scale genome data prior to downstream analyses.

"Just-in-Time" Personal Preparedness: Downloads and Usage Patterns of the American Red Cross Hurricane Application During Hurricane Sandy.

PubMed

Kirsch, Thomas D; Circh, Ryan; Bissell, Richard A; Goldfeder, Matthew

2016-10-01

Personal preparedness is a core activity but has been found to be frequently inadequate. Smart phone applications have many uses for the public, including preparedness. In 2012 the American Red Cross began releasing "disaster" apps for family preparedness and recovery. The Hurricane App was widely used during Hurricane Sandy in 2012. Patterns of download of the application were analyzed by using a download tracking tool by the American Red Cross and Google Analytics. Specific variables included date, time, and location of individual downloads; number of page visits and views; and average time spent on pages. As Hurricane Sandy approached in late October, daily downloads peaked at 152,258 on the day of landfall and by mid-November reached 697,585. Total page views began increasing on October 25 with over 4,000,000 page views during landfall compared to 3.7 million the first 3 weeks of October with a 43,980% increase in views of the "Right Before" page and a 76,275% increase in views of the "During" page. The Hurricane App offered a new type of "just-in-time" training that reached tens of thousands of families in areas affected by Hurricane Sandy. The app allowed these families to access real-time information before and after the storm to help them prepare and recover. (Disaster Med Public Health Preparedness. 2016;page 1 of 6).

Current Status of Cardiovascular Disease-Related Smartphone Apps Downloadable in China.

PubMed

Xiao, Qian; Lu, Sai; Wang, Yanling; Sun, Liu; Wu, Ying

2017-03-01

Smartphone apps present a great opportunity for the management of cardiovascular disease (CVD) as the adoption of apps becomes increasingly popular in China. Yet, little is known about the status of CVD-related Smartphone apps in the country. The aim of this study was to examine the current status of CVD-related smartphone apps available for download in China. Using CVD-related keywords written either in Chinese or English, the top 6 most popular smartphone app online stores in China were searched in September 2015. The information accountability of the selected apps was assessed with the Silberg scale. The key topic areas identified from the European Guidelines on cardiovascular disease prevention served to determine information coverage of the top 5 downloaded apps. The average Silberg score of 151 apps was 2.87 (out of 9) with most apps not revealing authors' qualifications and information references. There was also a lack of sponsorship disclosure and information update. Moreover, none of the top 5 downloaded apps covered all key areas of CVD management as recommended by the European Guidelines on cardiovascular disease prevention. There was little evidence of health professionals' involvement in the formation of the CVD-related apps. This study identified areas for improvement concerning information accountability and the scope of coverage of CVD-related apps downloadable in China. The findings may guide the future advancement of CVD-related apps and benefit CVD management in China.

WILBER and PyWEED: Event-based Seismic Data Request Tools

NASA Astrophysics Data System (ADS)

Falco, N.; Clark, A.; Trabant, C. M.

2017-12-01

WILBER and PyWEED are two user-friendly tools for requesting event-oriented seismic data. Both tools provide interactive maps and other controls for browsing and filtering event and station catalogs, and downloading data for selected event/station combinations, where the data window for each event/station pair may be defined relative to the arrival time of seismic waves from the event to that particular station. Both tools allow data to be previewed visually, and can download data in standard miniSEED, SAC, and other formats, complete with relevant metadata for performing instrument correction. WILBER is a web application requiring only a modern web browser. Once the user has selected an event, WILBER identifies all data available for that time period, and allows the user to select stations based on criteria such as the station's distance and orientation relative to the event. When the user has finalized their request, the data is collected and packaged on the IRIS server, and when it is ready the user is sent a link to download. PyWEED is a downloadable, cross-platform (Macintosh / Windows / Linux) application written in Python. PyWEED allows a user to select multiple events and stations, and will download data for each event/station combination selected. PyWEED is built around the ObsPy seismic toolkit, and allows direct interaction and control of the application through a Python interactive console.

Taiwan Ascii and Idl_save Data Archives (AIDA) for THEMIS

NASA Astrophysics Data System (ADS)

Lee, B.; Hsieh, W.; Shue, J.; Angelopoulos, V.; Glassmeier, K. H.; McFadden, J. P.; Larson, D.

2008-12-01

THEMIS (Time History of Events and their Macroscopic Interactions during Substorms) is a satellite mission that aims to determine where and how substorms are triggered. The space research team in Taiwan has been involved in data promotion and scientific research. Taiwan Ascii and Idl_save Data Archives (AIDA) for THEMIS is the main work of the data promotion. Taiwan AIDA is developed for those who are not familiar with the Interactive Data Language (IDL) data analysis and visualization software, and those who have some basic IDL concepts and techniques and want more flexibilities in reading and plotting the THEMIS data. Two kinds of data format are stored in Taiwan AIDA: one is ASCII format for most users and the other is IDL SAVE format for IDL users. The public can download THEMIS data in either format through the Taiwan AIDA web site, http://themis.ss.ncu.edu.tw/e_data_download.php. Taiwan AIDA provides (1) plasma data including number density, average temperature, and velocity of ions and electrons, (2) magnetic field data, and (3) state information including the position and velocity of five THEMIS probes. On the Taiwan AIDA web site there are two data-downloading options. The public can download a large amount of data for a particular instrument in the FTP equivalent option; the public can also download all the data for a particular date in the Data Search option.

Increase Productivity with Volunteers.

ERIC Educational Resources Information Center

Gray, Sandra T.

1984-01-01

The advantages of volunteer programs including school business partnerships are described, among which are cutting costs, improving productivity, increasing student achievement, and expanding community support. Hints for successful implementation are offered. (MJL)

A Novel Variant in the HINT1 Gene in a Girl with Autosomal Recessive Axonal Neuropathy with Neuromyotonia: Thorough Neurological Examination Gives the Clue.

PubMed

Rauchenzauner, Markus; Frühwirth, Martin; Hecht, Martin; Kofler, Markus; Witsch-Baumgartner, Martina; Fauth, Christine

2016-04-01

We report a girl with autosomal recessive axonal neuropathy with neuromyotonia (ARAN-NM) who presented with asymmetric gait impairment, foot drop, and action myotonia on fast handgrip. Electrophysiological studies showed symmetrical axonal motor greater than sensory neuropathy, and neuromyotonic discharges on needle electromyography. ARAN-NM was confirmed by molecular genetic testing, which revealed a novel homozygous missense variant c.100G > A [p.(Glu34Lys)] in HINT1. This case shows that the diagnosis of ARAN-NM, as a new entity, has to be considered in the differential diagnosis of polyneuropathy in combination with neuromyotonia/action myotonia in children, even with asymmetric clinical presentation. Georg Thieme Verlag KG Stuttgart · New York.

Neutrino parameters from reactor and accelerator neutrino experiments

NASA Astrophysics Data System (ADS)

Lindner, Manfred; Rodejohann, Werner; Xu, Xun-Jie

2018-04-01

We revisit correlations of neutrino oscillation parameters in reactor and long-baseline neutrino oscillation experiments. A framework based on an effective value of θ13 is presented, which can be used to analytically study the correlations and explain some questions including why and when δC P has the best fit value of -π /2 , why current and future long-baseline experiments will have less precision of δC P around ±π /2 than that around zero, etc. Recent hints on the C P phase are then considered from the point of view that different reactor and long-baseline neutrino experiments provide currently different best-fit values of θ13 and θ23. We point out that the significance of the hints changes for the different available best-fit values.

Improvements in speech understanding with wireless binaural broadband digital hearing instruments in adults with sensorineural hearing loss.

PubMed

Kreisman, Brian M; Mazevski, Annette G; Schum, Donald J; Sockalingam, Ravichandran

2010-03-01

This investigation examined whether speech intelligibility in noise can be improved using a new, binaural broadband hearing instrument system. Participants were 36 adults with symmetrical, sensorineural hearing loss (18 experienced hearing instrument users and 18 without prior experience). Participants were fit binaurally in a planned comparison, randomized crossover design study with binaural broadband hearing instruments and advanced digital hearing instruments. Following an adjustment period with each device, participants underwent two speech-in-noise tests: the QuickSIN and the Hearing in Noise Test (HINT). Results suggested significantly better performance on the QuickSIN and the HINT measures with the binaural broadband hearing instruments, when compared with the advanced digital hearing instruments and unaided, across and within all noise conditions.

Onsite Systems - Wastewater

Science.gov Websites

can help. Call NESC toll free at (304) 293-4191. or e-mail info@mail.nesc.wvu.edu and ask for different situations. Onsite Technologies for Small Communities Poster - NESC provides free downloads to . Downloads are free. This poster is available to order, charges apply to hard copies only. Pipeline

DOE Research and Development Accomplishments Help

Science.gov Websites

be used to search, locate, access, and electronically download full-text research and development (R Browse Downloading, Viewing, and/or Searching Full-text Documents/Pages Searching the Database Search Features Search allows you to search the OCRed full-text document and bibliographic information, the

Teaching Ethical Copyright Behavior: Assessing the Effects of a University-Sponsored Computing Ethics Program

ERIC Educational Resources Information Center

Siemens, Jennifer Christie; Kopp, Steven W.

2006-01-01

Universities have become sensitized to the potential for students' illegal downloading of copyrighted materials. Education has been advocated as one way to curb downloading of copyrighted digital content. This study investigates the effectiveness of a university-sponsored computing ethics education program. The program positively influenced…

Medical Device Plug-and-Play Interoperability Standards and Technology Leadership

DTIC Science & Technology

2014-10-01

downloads/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/ CDRH /CDRHReports/UCM391521.pdf. Dr. Goldman spoke in multiple panels at this workshop...downloads/AboutFDA/CentersOffices/OfficeofMedicalProductsandTo bacco/ CDRH /CDRHReports/UCM391521.pdf  Arney D, Plourde J, Schrenker R, Mattegunta P

Teaching and Learning Communities through Online Annotation

NASA Astrophysics Data System (ADS)

van der Pluijm, B.

2016-12-01

What do colleagues do with your assigned textbook? What they say or think about the material? Want students to be more engaged in their learning experience? If so, online materials that complement standard lecture format provide new opportunity through managed, online group annotation that leverages the ubiquity of internet access, while personalizing learning. The concept is illustrated with the new online textbook "Processes in Structural Geology and Tectonics", by Ben van der Pluijm and Stephen Marshak, which offers a platform for sharing of experiences, supplementary materials and approaches, including readings, mathematical applications, exercises, challenge questions, quizzes, alternative explanations, and more. The annotation framework used is Hypothes.is, which offers a free, open platform markup environment for annotation of websites and PDF postings. The annotations can be public, grouped or individualized, as desired, including export access and download of annotations. A teacher group, hosted by a moderator/owner, limits access to members of a user group of teachers, so that its members can use, copy or transcribe annotations for their own lesson material. Likewise, an instructor can host a student group that encourages sharing of observations, questions and answers among students and instructor. Also, the instructor can create one or more closed groups that offers study help and hints to students. Options galore, all of which aim to engage students and to promote greater responsibility for their learning experience. Beyond new capacity, the ability to analyze student annotation supports individual learners and their needs. For example, student notes can be analyzed for key phrases and concepts, and identify misunderstandings, omissions and problems. Also, example annotations can be shared to enhance notetaking skills and to help with studying. Lastly, online annotation allows active application to lecture posted slides, supporting real-time notetaking during lecture presentation. Sharing of experiences and practices of annotation could benefit teachers and learners alike, and does not require complicated software, coding skills or special hardware environments.

Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: a machine-learned analysis.

PubMed

Lötsch, Jörn; Geisslinger, Gerd; Heinemann, Sarah; Lerch, Florian; Oertel, Bruno G; Ultsch, Alfred

2017-08-16

The comprehensive assessment of pain-related human phenotypes requires combinations of nociceptive measures that produce complex high-dimensional data, posing challenges to bioinformatic analysis. In this study, we assessed established experimental models of heat hyperalgesia of the skin, consisting of local ultraviolet-B (UV-B) irradiation or capsaicin application, in 82 healthy subjects using a variety of noxious stimuli. We extended the original heat stimulation by applying cold and mechanical stimuli and assessing the hypersensitization effects with a clinically established quantitative sensory testing (QST) battery (German Research Network on Neuropathic Pain). This study provided a 246 × 10-sized data matrix (82 subjects assessed at baseline, following UV-B application, and following capsaicin application) with respect to 10 QST parameters, which we analyzed using machine-learning techniques. We observed statistically significant effects of the hypersensitization treatments in 9 different QST parameters. Supervised machine-learned analysis implemented as random forests followed by ABC analysis pointed to heat pain thresholds as the most relevantly affected QST parameter. However, decision tree analysis indicated that UV-B additionally modulated sensitivity to cold. Unsupervised machine-learning techniques, implemented as emergent self-organizing maps, hinted at subgroups responding to topical application of capsaicin. The distinction among subgroups was based on sensitivity to pressure pain, which could be attributed to sex differences, with women being more sensitive than men. Thus, while UV-B and capsaicin share a major component of heat pain sensitization, they differ in their effects on QST parameter patterns in healthy subjects, suggesting a lack of redundancy between these models.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Wing Download Results from a Test of a 0.658-Scale V-22 Rotor and Wing

NASA Technical Reports Server (NTRS)

Felker, Fort F.

1992-01-01

A test of a 0.658-scale V-22 rotor and wing was conducted in the 40 x 80 Foot Wind Tunnel at Ames Research Center. One of the principal objectives of the test was to measure the wing download in hover for a variety of test configurations. The wing download and surface pressures were measured for a wide range of thrust coefficients, with five different flap angles, two nacelle angles, and both directions or rotor rotation. This paper presents these results, and describes a new method for interpreting wing surface pressure data in hover. This method shows that the wing flap can produce substantial lift loads in hover.

First Aid and Safety

MedlinePlus

... First-Aid Kit Food Safety for Your Family Gun Safety Halloween Candy Hints Household Safety Checklists Household ... Climbing, and Grabbing Household Safety: Preventing Injuries From Firearms Household Safety: Preventing Injuries in the Crib Household ...

Molecular dynamics simulations of highly crowded amino acid solutions: comparisons of eight different force field combinations with experiment and with each other

PubMed Central

Andrews, Casey T.

2013-01-01

Although it is now commonly accepted that the highly crowded conditions encountered inside biological cells have the potential to significantly alter the thermodynamic properties of biomolecules, it is not known to what extent the thermodynamics of fundamental types of interactions such as salt bridges and hydrophobic interactions are strengthened or weakened by high biomolecular concentrations. As one way of addressing this question we have performed a series of all-atom explicit solvent molecular dynamics (MD) simulations to investigate the effect of increasing solute concentration on the behavior of four types of zwitterionic amino acids in aqueous solution. We have simulated systems containing glycine, valine, phenylalanine or asparagine at concentrations of 50, 100, 200 and 300 mg/ml. Each molecular system has been simulated for 1 μs in order to obtain statistically converged estimates of thermodynamic parameters, and each has been conducted with 8 different force fields and water models; the combined simulation time is 128 μs. The density, viscosity, and dielectric increments of the four amino acids calculated from the simulations have been compared to corresponding experimental measurements. While all of the force fields perform well at reproducing the density increments, discrepancies for the viscosity and dielectric increments raise questions both about the accuracy of the simulation force fields and, in certain cases, the experimental data. We also observe large differences between the various force fields' descriptions of the interaction thermodynamics of salt bridges and, surprisingly, these differences also lead to qualitatively different predictions of their dependences on solute concentration. For the aliphatic interactions of valine sidechains, fewer differences are observed between the force fields, but significant differences are again observed for aromatic interactions of phenylalanine sidechains. Taken together, the results highlight the potential power of using explicit-solvent simulation methods to understand behavior in concentrated systems but also hint at potential difficulties in using these methods to obtain consistent views of behavior in intracellular environments. PMID:24409104

40 CFR 1037.810 - Incorporation by reference.

Code of Federal Regulations, 2013 CFR

2013-07-01

... must publish a notice of the change in the Federal Register and the material must be available to the... software is also available for download at http://www.epa.gov/otaq/climate/gem.htm. (2) [Reserved] (d... working version of this software is also available for download at http://www.epa.gov/otaq/climate/gem.htm. ...

18 CFR 284.13 - Reporting requirements for interstate pipelines.

Code of Federal Regulations, 2011 CFR

2011-04-01

... following information on its Internet web site, and provide the information in downloadable file formats, in... index of customers must also posted on the pipeline's Internet web, in accordance with standards adopted in § 284.12 of this part, and made available from the Internet web site in a downloadable format...

18 CFR 284.13 - Reporting requirements for interstate pipelines.

Code of Federal Regulations, 2014 CFR

2014-04-01

... following information on its Internet web site, and provide the information in downloadable file formats, in... index of customers must also posted on the pipeline's Internet web, in accordance with standards adopted in § 284.12 of this part, and made available from the Internet web site in a downloadable format...

18 CFR 284.13 - Reporting requirements for interstate pipelines.

Code of Federal Regulations, 2013 CFR

2013-04-01

... following information on its Internet web site, and provide the information in downloadable file formats, in... index of customers must also posted on the pipeline's Internet web, in accordance with standards adopted in § 284.12 of this part, and made available from the Internet web site in a downloadable format...

18 CFR 284.13 - Reporting requirements for interstate pipelines.

Code of Federal Regulations, 2012 CFR

2012-04-01

... following information on its Internet web site, and provide the information in downloadable file formats, in... index of customers must also posted on the pipeline's Internet web, in accordance with standards adopted in § 284.12 of this part, and made available from the Internet web site in a downloadable format...

18 CFR 284.13 - Reporting requirements for interstate pipelines.

Code of Federal Regulations, 2010 CFR

2010-04-01

... following information on its Internet web site, and provide the information in downloadable file formats, in... index of customers must also posted on the pipeline's Internet web, in accordance with standards adopted in § 284.12 of this part, and made available from the Internet web site in a downloadable format...

18 CFR 37.7 - Auditing Transmission Service Information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT OPEN ACCESS SAME-TIME INFORMATION... time stamped. (b) Audit data must remain available for download on the OASIS for 90 days, except ATC/TTC postings that must remain available for download on the OASIS for 20 days. The audit data are to...

18 CFR 37.7 - Auditing Transmission Service Information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT OPEN ACCESS SAME-TIME INFORMATION... time stamped. (b) Audit data must remain available for download on the OASIS for 90 days, except ATC/TTC postings that must remain available for download on the OASIS for 20 days. The audit data are to...

Chapter 10: Enclosure--Building enclosure design for cross-laminated timber construction

Treesearch

Samuel V. Glass; Jieying Wang; Steve Easley; Graham Finch

2013-01-01

 Note: Clicking on the \\'View\\' option to download the PDF copy of the publication will redirect you to the web site www.masstimber.com where you will need to register prior to downloading.Cross-laminated timber #CLT# was developed in Europe for the prefabricated construction of wall, roof, and...

18 CFR 37.7 - Auditing Transmission Service Information.

Code of Federal Regulations, 2012 CFR

2012-04-01

... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT OPEN ACCESS SAME-TIME INFORMATION... time stamped. (b) Audit data must remain available for download on the OASIS for 90 days, except ATC/TTC postings that must remain available for download on the OASIS for 20 days. The audit data are to...

18 CFR 37.7 - Auditing Transmission Service Information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT OPEN ACCESS SAME-TIME INFORMATION... time stamped. (b) Audit data must remain available for download on the OASIS for 90 days, except ATC/TTC postings that must remain available for download on the OASIS for 20 days. The audit data are to...

18 CFR 37.7 - Auditing Transmission Service Information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT OPEN ACCESS SAME-TIME INFORMATION... time stamped. (b) Audit data must remain available for download on the OASIS for 90 days, except ATC/TTC postings that must remain available for download on the OASIS for 20 days. The audit data are to...

Alternative Fuels Data Center: Maps and Data

Science.gov Websites

Fuel Standard Volumes by Year Generated_thumb20150904-8240-13hgnxh Last update August 2012 View Graph product or destination Last update August 2015 View Graph Graph Download Data Custom_thumb U.S. Ethanol , from 1866-2014 Last update August 2015 View Graph Graph Download Data Generated_thumb20160920-21993

History of the Universe Poster

Science.gov Websites

History of the Universe Poster You are free to use these images if you give credit to: Particle Data Group at Lawrence Berkeley National Lab. New Version (2014) History of the Universe Poster Download: JPEG version PDF version Old Version (2013) History of the Universe Poster Download: JPEG version

The Lowdown on Audio Downloads

ERIC Educational Resources Information Center

Farrell, Beth

2010-01-01

First offered to public libraries in 2004, downloadable audiobooks have grown by leaps and bounds. According to the Audio Publishers Association, their sales today account for 21% of the spoken-word audio market. It hasn't been easy, however. WMA. DRM. MP3. AAC. File extensions small on letters but very big on consequences for librarians,…

Supporting Business Students' Transition into Higher Education: The Case of Marketing Downloads

ERIC Educational Resources Information Center

Anderson, Deborah; Wason, Hilary; Southall, Jane

2016-01-01

This paper discusses a student-centred learning and teaching approach, "Marketing Downloads", designed to support students in transition into Higher Education. The move from secondary to tertiary education can be stressful for students and it impacts on their academic performance, their social life and general sense of well-being.…

FOSS Tools for Research Data Management

NASA Astrophysics Data System (ADS)

Stender, Vivien; Jankowski, Cedric; Hammitzsch, Martin; Wächter, Joachim

2017-04-01

Established initiatives and organizations, e.g. the Initiative for Scientific Cyberinfrastructures (NSF, 2007) or the European Strategy Forum on Research Infrastructures (ESFRI, 2008), promote and foster the development of sustainable research infrastructures. These infrastructures aim the provision of services supporting scientists to search, visualize and access data, to collaborate and exchange information, as well as to publish data and other results. In this regard, Research Data Management (RDM) gains importance and thus requires the support by appropriate tools integrated in these infrastructures. Different projects provide arbitrary solutions to manage research data. However, within two projects - SUMARIO for land and water management and TERENO for environmental monitoring - solutions to manage research data have been developed based on Free and Open Source Software (FOSS) components. The resulting framework provides essential components for harvesting, storing and documenting research data, as well as for discovering, visualizing and downloading these data on the basis of standardized services stimulated considerably by enhanced data management approaches of Spatial Data Infrastructures (SDI). In order to fully exploit the potentials of these developments for enhancing data management in Geosciences the publication of software components, e.g. via GitHub, is not sufficient. We will use our experience to move these solutions into the cloud e.g. as PaaS or SaaS offerings. Our contribution will present data management solutions for the Geosciences developed in two projects. A sort of construction kit with FOSS components build the backbone for the assembly and implementation of projects specific platforms. Furthermore, an approach is presented to stimulate the reuse of FOSS RDM solutions with cloud concepts. In further projects specific RDM platforms can be set-up much faster, customized to the individual needs and tools can be added during the run-time.

Cloud archiving and data mining of High-Resolution Rapid Refresh forecast model output

NASA Astrophysics Data System (ADS)

Blaylock, Brian K.; Horel, John D.; Liston, Samuel T.

2017-12-01

Weather-related research often requires synthesizing vast amounts of data that need archival solutions that are both economical and viable during and past the lifetime of the project. Public cloud computing services (e.g., from Amazon, Microsoft, or Google) or private clouds managed by research institutions are providing object data storage systems potentially appropriate for long-term archives of such large geophysical data sets. We illustrate the use of a private cloud object store developed by the Center for High Performance Computing (CHPC) at the University of Utah. Since early 2015, we have been archiving thousands of two-dimensional gridded fields (each one containing over 1.9 million values over the contiguous United States) from the High-Resolution Rapid Refresh (HRRR) data assimilation and forecast modeling system. The archive is being used for retrospective analyses of meteorological conditions during high-impact weather events, assessing the accuracy of the HRRR forecasts, and providing initial and boundary conditions for research simulations. The archive is accessible interactively and through automated download procedures for researchers at other institutions that can be tailored by the user to extract individual two-dimensional grids from within the highly compressed files. Characteristics of the CHPC object storage system are summarized relative to network file system storage or tape storage solutions. The CHPC storage system is proving to be a scalable, reliable, extensible, affordable, and usable archive solution for our research.

TRAC, a collaborative computer tool for tracer-test interpretation

NASA Astrophysics Data System (ADS)

Gutierrez, A.; Klinka, T.; Thiéry, D.; Buscarlet, E.; Binet, S.; Jozja, N.; Défarge, C.; Leclerc, B.; Fécamp, C.; Ahumada, Y.; Elsass, J.

2013-05-01

Artificial tracer tests are widely used by consulting engineers for demonstrating water circulation, proving the existence of leakage, or estimating groundwater velocity. However, the interpretation of such tests is often very basic, with the result that decision makers and professionals commonly face unreliable results through hasty and empirical interpretation. There is thus an increasing need for a reliable interpretation tool, compatible with the latest operating systems and available in several languages. BRGM, the French Geological Survey, has developed a project together with hydrogeologists from various other organizations to build software assembling several analytical solutions in order to comply with various field contexts. This computer program, called TRAC, is very light and simple, allowing the user to add his own analytical solution if the formula is not yet included. It aims at collaborative improvement by sharing the tool and the solutions. TRAC can be used for interpreting data recovered from a tracer test as well as for simulating the transport of a tracer in the saturated zone (for the time being). Calibration of a site operation is based on considering the hydrodynamic and hydrodispersive features of groundwater flow as well as the amount, nature and injection mode of the artificial tracer. The software is available in French, English and Spanish, and the latest version can be downloaded from the web site http://trac.brgm.fr">http://trac.brgm.fr.

CONAN: copy number variation analysis software for genome-wide association studies

PubMed Central

2010-01-01

Background Genome-wide association studies (GWAS) based on single nucleotide polymorphisms (SNPs) revolutionized our perception of the genetic regulation of complex traits and diseases. Copy number variations (CNVs) promise to shed additional light on the genetic basis of monogenic as well as complex diseases and phenotypes. Indeed, the number of detected associations between CNVs and certain phenotypes are constantly increasing. However, while several software packages support the determination of CNVs from SNP chip data, the downstream statistical inference of CNV-phenotype associations is still subject to complicated and inefficient in-house solutions, thus strongly limiting the performance of GWAS based on CNVs. Results CONAN is a freely available client-server software solution which provides an intuitive graphical user interface for categorizing, analyzing and associating CNVs with phenotypes. Moreover, CONAN assists the evaluation process by visualizing detected associations via Manhattan plots in order to enable a rapid identification of genome-wide significant CNV regions. Various file formats including the information on CNVs in population samples are supported as input data. Conclusions CONAN facilitates the performance of GWAS based on CNVs and the visual analysis of calculated results. CONAN provides a rapid, valid and straightforward software solution to identify genetic variation underlying the 'missing' heritability for complex traits that remains unexplained by recent GWAS. The freely available software can be downloaded at http://genepi-conan.i-med.ac.at. PMID:20546565

LS-APC v1.0: a tuning-free method for the linear inverse problem and its application to source-term determination

NASA Astrophysics Data System (ADS)

Tichý, Ondřej; Šmídl, Václav; Hofman, Radek; Stohl, Andreas

2016-11-01

Estimation of pollutant releases into the atmosphere is an important problem in the environmental sciences. It is typically formalized as an inverse problem using a linear model that can explain observable quantities (e.g., concentrations or deposition values) as a product of the source-receptor sensitivity (SRS) matrix obtained from an atmospheric transport model multiplied by the unknown source-term vector. Since this problem is typically ill-posed, current state-of-the-art methods are based on regularization of the problem and solution of a formulated optimization problem. This procedure depends on manual settings of uncertainties that are often very poorly quantified, effectively making them tuning parameters. We formulate a probabilistic model, that has the same maximum likelihood solution as the conventional method using pre-specified uncertainties. Replacement of the maximum likelihood solution by full Bayesian estimation also allows estimation of all tuning parameters from the measurements. The estimation procedure is based on the variational Bayes approximation which is evaluated by an iterative algorithm. The resulting method is thus very similar to the conventional approach, but with the possibility to also estimate all tuning parameters from the observations. The proposed algorithm is tested and compared with the standard methods on data from the European Tracer Experiment (ETEX) where advantages of the new method are demonstrated. A MATLAB implementation of the proposed algorithm is available for download.

Development of Download System for Waveform Data Observed at Long-Term Borehole Monitoring System installed in the Nankai Trough

NASA Astrophysics Data System (ADS)

Horikawa, H.; Takaesu, M.; Sueki, K.; Araki, E.; Sonoda, A.; Takahashi, N.; Tsuboi, S.

2015-12-01

The Nankai Trough in southwest Japan is one of most active subduction zone in the world. Great mega-thrust earthquakes repeatedly occurred every 100 to 150 years in this area, it's anticipated to occur in the not distant future. For the purpose of elucidation of the history of mega-splay fault activity, the physical properties of the geological strata and the internal structure of the accretionary prism, and monitoring of diastrophism in this area, we have a plan, Nankai Trough Seismogenic Zone Experiments (NanTroSEIZE), as a part of Integrated Ocean Drilling Program (IODP).We have a plan to install the borehole observation system in a few locations by the NanTroSEIZE. This system is called Long-Term Borehole Monitoring System, it consists of various sensors in the borehole such as a broadband seismometer, a tiltmeter, a strainmeter, geophones and accelerometer, thermometer array as well as pressure ports for pore-fluid pressure monitoring. The signal from sensors is transmitted to DONET (Dense Ocean-floor Network System for Earthquake and Tsunamis) in real-time. During IODP Exp. 332 in December 2010, the first Long-Term Borehole Monitoring System was installed into the C0002 borehole site located 80 km off the Kii Peninsula, 1938 m water depth in the Nankai Trough.We have developed a web application system for data download, Long-Term Borehole Monitoring Data Site　(*1). Based on a term and sensors which user selected on this site, user can download monitoring waveform data (e.g. broadband seismometer data, accelerometer data, strainmeter data, tiltmeter data) in near real-time. This system can make the arbitrary data which user selected a term and sensors, and download it simply. Downloadable continuous data is provided in seed format, which includes sensor information. In addition, before data download, user can check that data is available or not by data check function.In this presentation, we briefly introduce NanTroSEIZE and then show our web　application system. We also discuss our future plans for developments of monitoring data download system.*1 Long-Term Borehole Monitoring Data Site http://join-web.jamstec.go.jp/borehole/borehole_top_e.html

Accustomed to Her Face

NASA Image and Video Library

2007-06-26

After nearly three years at Saturn, the Cassini spacecraft continues to observe the planet retinue of icy moons. Rhea cratered face attests to its great age, while its bright wisps hint at tectonic activity in the past

Are You a Gut Responder? Hints on Coping with an Irritable Bowel

MedlinePlus

... Colonoscopy Diet & Treatments Antacids Calcium in Non-Dairy Foods Chlorophyllin for Odor Control Dietary Fiber High Colonics NSAIDs Could Probiotics Help Your Symptoms? Use of Probiotics in Managing ...

ScienceCast 107: An Early Start for Noctilucent Clouds

NASA Image and Video Library

2013-06-07

Glowing electric-blue at the edge of space, noctilucent clouds have surprised researchers by appearing early this year. The unexpected apparition hints at a change in the "teleconnections" of Earth's atmosphere.

Put a Short-Wave Radio in Your Foreign Language Classroom

ERIC Educational Resources Information Center

Oksenholt, Svein

1977-01-01

Advantages of the short-wave radio as a supplement to foreign language instruction as well as practical hints on wavelength, antenna, and techniques for use are provided. Selective annotated bibliography. (STS)

Mimas...and Titan Beyond

NASA Image and Video Library

2006-01-03

Titan, Saturn largest moon and Mimas in the foreground are seen together in this view from Cassini. Titan gravity is weaker than Earth, so the moon atmosphere is quite extended -- a quality hinted at in this view

The Tale Continues...

NASA Image and Video Library

2012-04-16

The brightly reflective moon Enceladus appears before Saturn rings while the larger moon Titan looms in the distance. Jets of water ice and vapor emanating from the south pole of Enceladus hinting at subsurface sea rich in organics.

Review of ADHD Pharmacotherapies: Advantages, Disadvantages, and Clinical Pearls

ERIC Educational Resources Information Center

Daughton, Joan M.; Kratochvil, Christopher J.

2009-01-01

The advantages, disadvantages, as well as helpful hints on when to use several drug therapies against attention deficit hyperactivity disorder are discussed. The drugs discussed are methylphenidate, atomoxetine, clonidine, and bupropion.

At Home with MS: Adapting Your Environment

MedlinePlus

... improvement. You need not become an efficiency or design expert to develop an interest in making life ... general household hints, getting organized, work simplification, interior design, home remodeling, and home repair. The resources can ...

Progressive Supranuclear Palsy (PSP): Frequently Asked Questions

MedlinePlus

... diet may contribute to the cause of PSP. Surveys of PSP patients have hinted at a predilection ... atypical parkinsonisms” than are people elsewhere. A questionnaire survey on Guadeloupe revealed that people with PSP-like ...

Prospects to verify a possible dark matter hint in cosmic antiprotons with antideuterons and antihelium

NASA Astrophysics Data System (ADS)

Korsmeier, Michael; Donato, Fiorenza; Fornengo, Nicolao

2018-05-01

Cosmic rays are an important tool to study dark matter (DM) annihilation in our Galaxy. Recently, a possible hint for dark matter annihilation was found in the antiproton spectrum measured by AMS-02, even though the result might be affected by theoretical uncertainties. A complementary way to test its dark matter interpretation would be the observation of low-energy antinuclei in cosmic rays. We determine the chances to observe antideuterons with GAPS and AMS-02 and the implications for the ongoing AMS-02 antihelium searches. We find that the corresponding antideuteron signal is within the GAPS and AMS-02 detection potential. If, more conservatively, the putative signal was considered as an upper limit on DM annihilation, our results would indicate the highest possible fluxes for antideuterons and antihelium compatible with current antiproton data.

Searching for New Physics with b →s τ+τ- Processes

NASA Astrophysics Data System (ADS)

Capdevila, Bernat; Crivellin, Andreas; Descotes-Genon, Sébastien; Hofer, Lars; Matias, Joaquim

2018-05-01

In recent years, intriguing hints for the violation of lepton flavor universality (LFU) have been accumulated in semileptonic B decays, both in the charged-current transitions b →c ℓ-ν¯ℓ(i.e., RD, RD*,and RJ /ψ) and the neutral-current transitions b →s ℓ+ℓ-(i.e., RK and RK*). Hints for LFU violation in RD(*) and RJ /ψ point at large deviations from the standard model (SM) in processes involving tau leptons. Moreover, LHCb has reported deviations from the SM expectations in b →s μ+μ- processes as well as in the ratios RK and RK*, which together point at new physics (NP) affecting muons with a high significance. These hints for NP suggest the possibility of huge LFU-violating effects in b →s τ+τ- transitions. In this Letter, we predict the branching ratios of B →K τ+τ-, B →K*τ+τ-, and Bs→ϕ τ+τ-, taking into account NP effects in the Wilson coefficients C9(') ττ and C10(') τ τ. Assuming a common NP explanation of RD , RD(*), and RJ /ψ, we show that a very large enhancement of b →s τ+τ- processes, of around 3 orders of magnitude compared to the SM, can be expected under fairly general assumptions. We find that the branching ratios of Bs→τ+τ-, Bs→ϕ τ+τ-, and B →K(*)τ+τ- under these assumptions are in the observable range for LHCb and Belle II.

Intuitive, but not simple: including explicit water molecules in protein-protein docking simulations improves model quality.

PubMed

Parikh, Hardik I; Kellogg, Glen E

2014-06-01

Characterizing the nature of interaction between proteins that have not been experimentally cocrystallized requires a computational docking approach that can successfully predict the spatial conformation adopted in the complex. In this work, the Hydropathic INTeractions (HINT) force field model was used for scoring docked models in a data set of 30 high-resolution crystallographically characterized "dry" protein-protein complexes and was shown to reliably identify native-like models. However, most current protein-protein docking algorithms fail to explicitly account for water molecules involved in bridging interactions that mediate and stabilize the association of the protein partners, so we used HINT to illuminate the physical and chemical properties of bridging waters and account for their energetic stabilizing contributions. The HINT water Relevance metric identified the "truly" bridging waters at the 30 protein-protein interfaces and we utilized them in "solvated" docking by manually inserting them into the input files for the rigid body ZDOCK program. By accounting for these interfacial waters, a statistically significant improvement of ∼24% in the average hit-count within the top-10 predictions the protein-protein dataset was seen, compared to standard "dry" docking. The results also show scoring improvement, with medium and high accuracy models ranking much better than incorrect ones. These improvements can be attributed to the physical presence of water molecules that alter surface properties and better represent native shape and hydropathic complementarity between interacting partners, with concomitantly more accurate native-like structure predictions. © 2013 Wiley Periodicals, Inc.

[Adaptation of the Hinting Task theory of the mind test to Spanish].

PubMed

Gil, David; Fernández-Modamio, Mar; Bengochea, Rosario; Arrieta, Marta

2012-01-01

Many studies have found that patients with schizophrenia have a deficit in theory of mind. Some authors associate this deficit with the presence of symptoms, while others maintain that it can also be observed in patients in the remission phase. There is no reference test to assess theory of mind in schizophrenia, although one of the most used is the Hinting Task. The aim of the present study consists of adapting and validating, in Spanish, the 10 histories that make up this test. The study was conducted on a sample of 39 control subjects and 40 patients with schizophrenia. The internal consistency and the between-observer reliability and test-retest were assessed in both sample groups. The performance of the patients and control subjects were also compared. Good reliability data was obtained in the inter-observer and test-retest in the two samples. On the other hand, the internal consistency was somewhat low for all of the 10 histories. For this reason, and starting from a previous study, a reduced version of 5 histories was prepared, which showed good internal consistency. The patients with schizophrenia obtained a significantly lower score than the control subjects in 8 out of the 10 histories. The reduced Spanish version of the Hinting Task demonstrated good psychometric properties. When compared to the control group, the patients with schizophrenia had a deficit in theory of mind. Copyright © 2011 SEP y SEPB. Published by Elsevier Espana. All rights reserved.

Bayesian analysis of multiple direct detection experiments

NASA Astrophysics Data System (ADS)

Arina, Chiara

2014-12-01

Bayesian methods offer a coherent and efficient framework for implementing uncertainties into induction problems. In this article, we review how this approach applies to the analysis of dark matter direct detection experiments. In particular we discuss the exclusion limit of XENON100 and the debated hints of detection under the hypothesis of a WIMP signal. Within parameter inference, marginalizing consistently over uncertainties to extract robust posterior probability distributions, we find that the claimed tension between XENON100 and the other experiments can be partially alleviated in isospin violating scenario, while elastic scattering model appears to be compatible with the frequentist statistical approach. We then move to model comparison, for which Bayesian methods are particularly well suited. Firstly, we investigate the annual modulation seen in CoGeNT data, finding that there is weak evidence for a modulation. Modulation models due to other physics compare unfavorably with the WIMP models, paying the price for their excessive complexity. Secondly, we confront several coherent scattering models to determine the current best physical scenario compatible with the experimental hints. We find that exothermic and inelastic dark matter are moderatly disfavored against the elastic scenario, while the isospin violating model has a similar evidence. Lastly the Bayes' factor gives inconclusive evidence for an incompatibility between the data sets of XENON100 and the hints of detection. The same question assessed with goodness of fit would indicate a 2 σ discrepancy. This suggests that more data are therefore needed to settle this question.

Effect of type of noise and loudspeaker array on the performance of omnidirectional and directional microphones.

PubMed

Valente, Michael; Mispagel, Karen M; Tchorz, Juergen; Fabry, David

2006-06-01

Differences in performance between omnidirectional and directional microphones were evaluated between two loudspeaker conditions (single loudspeaker at 180 degrees; diffuse using eight loudspeakers set 45 degrees apart) and two types of noise (steady-state HINT noise; R-Space restaurant noise). Twenty-five participants were fit bilaterally with Phonak Perseo hearing aids using the manufacturer's recommended procedure. After wearing the hearing aids for one week, the parameters were fine-tuned based on subjective comments. Four weeks later, differences in performance between omnidirectional and directional microphones were assessed using HINT sentences presented at 0 degrees with the two types of background noise held constant at 65 dBA and under the two loudspeaker conditions. Results revealed significant differences in Reception Thresholds for Sentences (RTS in dB) where directional performance was significantly better than omnidirectional. Performance in the 180 degrees condition was significantly better than the diffuse condition, and performance was significantly better using the HINT noise in comparison to the R-Space restaurant noise. In addition, results revealed that within each loudspeaker array, performance was significantly better for the directional microphone. Looking across loudspeaker arrays, however, significant differences were not present in omnidirectional performance, but directional performance was significantly better in the 180 degrees condition when compared to the diffuse condition. These findings are discussed in terms of results reported in the past and counseling patients on the potential advantages of directional microphones as the listening situation and type of noise changes.

Structure-property relations of orthorhombic [(CH3)3NCH2COO]2(CuCl2)3 · 2H2 O

NASA Astrophysics Data System (ADS)

Haussühl, Eiken; Schreuer, Jürgen; Wiehl, Leonore; Paulsen, Natalia

2014-04-01

Large single crystals of orthorhombic [(CH3)3NCH2COO]2(CuCl2)3 · 2H2 O with dimensions up to 40×40×30 mm3 were grown from aqueous solutions. The elastic and piezoelastic coefficients were derived from ultrasonic resonance frequencies and their shifts upon variation of pressure, respectively, using the plate-resonance technique. Additionally, the coefficients of thermal expansion were determined between 95 K and 305 K by dilatometry. The elastic behaviour at ambient conditions is dominated by the 2-dimensional network of strong hydrogen bonds within the (001) plane leading to a corresponding pseudo-tetragonal anisotropy of the longitudinal elastic stiffness. The variation of elastic properties with pressure, however, as well as the thermal expansion shows strong deviations from the pseudo-tetragonal symmetry. These deviations are probably correlated with tilts of the elongated tri-nuclear betaine-CuCl2-water complexes. Neither the thermal expansion nor the specific heat capacity gives any hint on a phase transition in the investigated temperature range.

Endophilin-A1 BAR domain interaction with arachidonyl CoA.

PubMed

Petoukhov, Maxim V; Weissenhorn, Winfried; Svergun, Dmitri I

2014-01-01

Endophilin-A1 belongs to the family of BAR domain containing proteins that catalyze membrane remodeling processes via sensing, inducing and stabilizing membrane curvature. We show that the BAR domain of endophilin-A1 binds arachidonic acid and molds its coenzyme A (CoA) activated form, arachidonyl-CoA into a defined structure. We studied low resolution structures of endophilin-A1-BAR and its complex with arachidonyl-CoA in solution using synchrotron small-angle X-ray scattering (SAXS). The free endophilin-A1-BAR domain is shown to be dimeric at lower concentrations but builds tetramers and higher order complexes with increasing concentrations. Extensive titration SAXS studies revealed that the BAR domain produces a homogenous complex with the lipid micelles. The structural model of the complexes revealed two arachidonyl-CoA micelles bound to the distal arms of an endophilin-A1-BAR dimer. Intriguingly, the radius of the bound micelles significantly decreases compared to that of the free micelles, and this structural result may provide hints on the potential biological relevance of the endophilin-A1-BAR interaction with arachidonyl CoA.

Gamma-ray timing of redback PSR J2339-0533: Hints for gravitational quadrupole moment changes

DOE PAGES

Pletsch, Holger J.; Clark, Colin J.

2015-06-25

Here, we present the results of precision gamma-ray timing measurements of the binary millisecond pulsar PSR J2339–0533, an irradiating system of the "redback" type, using data from the Fermi Large Area Telescope. We describe an optimized analysis method to determine a long-term phase-coherent timing solution spanning more than six years, including a measured eccentricity of the binary orbit and constraints on the proper motion of the system. A major result of this timing analysis is the discovery of an extreme variation of the nominal 4.6 hr orbital periodmore » $${P}_{\\mathrm{orb}}$$ over time, showing alternating epochs of decrease and increase. We inferred a cyclic modulation of $${P}_{\\mathrm{orb}}$$ with an approximate cycle duration of 4.2 yr and a modulation amplitude of $${\\rm{\\Delta }}{P}_{\\mathrm{orb}}/{P}_{\\mathrm{orb}}=2.3\\times {10}^{-7}$$. Considering different possible physical causes, the observed orbital-period modulation most likely results from a variable gravitational quadrupole moment of the companion star due to cyclic magnetic activity in its convective zone.« less

Optimal Concentrations in Transport Networks

NASA Astrophysics Data System (ADS)

Jensen, Kaare; Savage, Jessica; Kim, Wonjung; Bush, John; Holbrook, N. Michele

2013-03-01

Biological and man-made systems rely on effective transport networks for distribution of material and energy. Mass flow in these networks is determined by the flow rate and the concentration of material. While the most concentrated solution offers the greatest potential for mass flow, impedance grows with concentration and thus makes it the most difficult to transport. The concentration at which mass flow is optimal depends on specific physical and physiological properties of the system. We derive a simple model which is able to predict optimal concentrations observed in blood flows, sugar transport in plants, and nectar feeding animals. Our model predicts that the viscosity at the optimal concentration μopt =2nμ0 is an integer power of two times the viscosity of the pure carrier medium μ0. We show how the observed powers 1 <= n <= 6 agree well with theory and discuss how n depends on biological constraints imposed on the transport process. The model provides a universal framework for studying flows impeded by concentration and provides hints of how to optimize engineered flow systems, such as congestion in traffic flows.

Computational screening of organic materials towards improved photovoltaic properties

NASA Astrophysics Data System (ADS)

Dai, Shuo; Olivares-Amaya, Roberto; Amador-Bedolla, Carlos; Aspuru-Guzik, Alan; Borunda, Mario

2015-03-01

The world today faces an energy crisis that is an obstruction to the development of the human civilization. One of the most promising solutions is solar energy harvested by economical solar cells. Being the third generation of solar cell materials, organic photovoltaic (OPV) materials is now under active development from both theoretical and experimental points of view. In this study, we constructed a parameter to select the desired molecules based on their optical spectra performance. We applied it to investigate a large collection of potential OPV materials, which were from the CEPDB database set up by the Harvard Clean Energy Project. Time dependent density functional theory (TD-DFT) modeling was used to calculate the absorption spectra of the molecules. Then based on the parameter, we screened out the top performing molecules for their potential OPV usage and suggested experimental efforts toward their synthesis. In addition, from those molecules, we summarized the functional groups that provided molecules certain spectrum capability. It is hoped that useful information could be mined out to provide hints to molecular design of OPV materials.

Raw and processed ground-penetrating radar and postprocessed differential global positioning system data collected from Assateague Island, Maryland, October 2014

USGS Publications Warehouse

Zaremba, Nicholas J.; Bernier, Julie C.; Forde, Arnell S.; Smith, Christopher G.

2016-06-08

This report serves as an archive of GPR and DGPS data collected from Assateague Island in October 2014. Data products, including raw GPR and processed DGPS data, elevation corrected GPR profiles, and accompanying Federal Geographic Data Committee metadata can be downloaded from the Data Downloads page.

Alternative Fuels Data Center: Maps and Data

Science.gov Websites

fleet type from 1992-2014 Last update August 2016 View Graph Graph Download Data Generated_thumb20160830 Trend of S&FP AFV acquisitions by fuel type from 1992-2015 Last update August 2016 View Graph Graph transactions from 1997-2014 Last update August 2016 View Graph Graph Download Data Biofuelsatlas BioFuels Atlas

Alternative Fuels Data Center: Maps and Data

Science.gov Websites

-1paywcu Last update August 2014 View Graph Graph Download Data State & Alt Fuel Providers -kgi9ks Trend of S&FP AFV acquisitions by fleet type from 1992-2014 Last update August 2016 View Graph -2015 Last update August 2016 View Graph Graph Download Data Generated_thumb20160907-12999-119sgvk

Challenges of working with FIADB17 data: the SOLE experience

Treesearch

Michael Spinney; Paul Van Deusen

2007-01-01

The Southern On Line Estimator (SOLE) is an Internet-based Forest Inventory and Analysis (FIA) data analysis tool. SOLE is based on data downloaded from the publicly available FIA database (FIADB) and summarized by plot condition. The tasks of downloading, processing, and summarizing FIADB data require specialized expertise in inventory theory and data manipulation....

Cultivating Innovation to Ignite Organizational Transformation

DTIC Science & Technology

2004-03-01

over a modem . Need to have a section entitled "incoming students" The current site and design sitemap make and incoming student hunt through the...Download Times: Estimated download times (seconds) Object type Number Size (bytes) 14.4 28.8 33.6 56K 128K T1 HTML 1 8600 6.27 3.44 2.87 2.46

Python for large-scale electrophysiology.

PubMed

Spacek, Martin; Blanche, Tim; Swindale, Nicholas

2008-01-01

Electrophysiology is increasingly moving towards highly parallel recording techniques which generate large data sets. We record extracellularly in vivo in cat and rat visual cortex with 54-channel silicon polytrodes, under time-locked visual stimulation, from localized neuronal populations within a cortical column. To help deal with the complexity of generating and analysing these data, we used the Python programming language to develop three software projects: one for temporally precise visual stimulus generation ("dimstim"); one for electrophysiological waveform visualization and spike sorting ("spyke"); and one for spike train and stimulus analysis ("neuropy"). All three are open source and available for download (http://swindale.ecc.ubc.ca/code). The requirements and solutions for these projects differed greatly, yet we found Python to be well suited for all three. Here we present our software as a showcase of the extensive capabilities of Python in neuroscience.

Abschätzung des Einflusses von Parameterunsicherheiten bei der Planung und Auswertung von Tracertests unter Verwendung von Ensembleprognosen

NASA Astrophysics Data System (ADS)

Klotzsch, Stephan; Binder, Martin; Händel, Falk

2017-06-01

While planning tracer tests, uncertainties in geohydraulic parameters should be considered as an important factor. Neglecting these uncertainties can lead to missing the tracer breakthrough, for example. One way to consider uncertainties during tracer test design is the so called ensemble forecast. The applicability of this method to geohydrological problems is demonstrated by coupling the method with two analytical solute transport models. The algorithm presented in this article is suitable for prediction as well as parameter estimation. The parameter estimation function can be used in a tracer test for reducing the uncertainties in the measured data which can improve the initial prediction. The algorithm was implemented into a software tool which is freely downloadable from the website of the Institute for Groundwater Management at TU Dresden, Germany.

Systems of fuzzy equations in structural mechanics

NASA Astrophysics Data System (ADS)

Skalna, Iwona; Rama Rao, M. V.; Pownuk, Andrzej

2008-08-01

Systems of linear and nonlinear equations with fuzzy parameters are relevant to many practical problems arising in structure mechanics, electrical engineering, finance, economics and physics. In this paper three methods for solving such equations are discussed: method for outer interval solution of systems of linear equations depending linearly on interval parameters, fuzzy finite element method proposed by Rama Rao and sensitivity analysis method. The performance and advantages of presented methods are described with illustrative examples. Extended version of the present paper can be downloaded from the web page of the UTEP [I. Skalna, M.V. Rama Rao, A. Pownuk, Systems of fuzzy equations in structural mechanics, The University of Texas at El Paso, Department of Mathematical Sciences Research Reports Series, , Texas Research Report No. 2007-01, 2007].

Birds of a Feather: Supporting Secure Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Braswell III, H V

2006-04-24

Over the past few years Lawrence Livermore National Laboratory has begun the process of moving to a diskless environment in the Secure Computer Support realm. This movement has included many moving targets and increasing support complexity. We would like to set up a forum for Security and Support professionals to get together from across the Complex and discuss current deployments, lessons learned, and next steps. This would include what hardware, software, and hard copy based solutions are being used to manage Secure Computing. The topics to be discussed include but are not limited to: Diskless computing, port locking and management,more » PC, Mac, and Linux/UNIX support and setup, system imaging, security setup documentation and templates, security documentation and management, customer tracking, ticket tracking, software download and management, log management, backup/disaster recovery, and mixed media environments.« less

ROCView: prototype software for data collection in jackknife alternative free-response receiver operating characteristic analysis

PubMed Central

Thompson, J; Hogg, P; Thompson, S; Manning, D; Szczepura, K

2012-01-01

ROCView has been developed as an image display and response capture (IDRC) solution to image display and consistent recording of reader responses in relation to the free-response receiver operating characteristic paradigm. A web-based solution to IDRC for observer response studies allows observations to be completed from any location, assuming that display performance and viewing conditions are consistent with the study being completed. The simplistic functionality of the software allows observations to be completed without supervision. ROCView can display images from multiple modalities, in a randomised order if required. Following registration, observers are prompted to begin their image evaluation. All data are recorded via mouse clicks, one to localise (mark) and one to score confidence (rate) using either an ordinal or continuous rating scale. Up to nine “mark-rating” pairs can be made per image. Unmarked images are given a default score of zero. Upon completion of the study, both true-positive and false-positive reports can be downloaded and adapted for analysis. ROCView has the potential to be a useful tool in the assessment of modality performance difference for a range of imaging methods. PMID:22573294

Writing for Profit: A Catalog of Hints.

ERIC Educational Resources Information Center

Barnum, Carol M.

1981-01-01

Offers tips to business communication teachers on how to write for money. Tips include: (1) Begin by writing for free, (2) use business contacts, (3) vary approaches to writing, and (4) write about personal experiences. (FL)

[Phaedra's disease].

PubMed

Bonuzzi, Luciano

2012-01-01

The author hints at Phaedra's passion, described by Euripides, highlighting in particular the incest taboo. As well known, Phaedra in fact is love-sick for her own step-son Hippolytus, a human figure with a not well defined sexual identity.

Analysis of Alcohols.

ERIC Educational Resources Information Center

McCullough, Brother Thomas

1984-01-01

Presents a novel approach to identification of unknown alcohols using experimental measurements of boiling point and viscosity which are easily obtained without expensive equipment of instrumentation. Provides instructions for preparing capillary viscometer, listing special hints for obtaining good results. (JM)

Simulation of the Chang'E-5 mission contribution in lunar long wavelength gravity field improvement

NASA Astrophysics Data System (ADS)

Yan, Jianguo; Yang, Xuan; Ping, Jinsong; Ye, Mao; Liu, Shanhong; Jin, Weitong; Li, Fei; Barriot, Jean-Pierre

2018-06-01

The precision of lunar gravity field estimation has improved by means of three to five orders of magnitude since the successful GRAIL lunar mission. There are still discrepancies however, in the low degree coefficients and long wavelength components of the solutions developed by two space research centers (JPL and GSFC). These discrepancies hint at the possibilities for improving the accuracy in the long wavelength part of the lunar gravity field. In the near future, China will launch the Chang'E-5 lunar mission. In this sample-return mission, there will be a chance to do KBRR measurements between an ascending module and an orbiting module. These two modules will fly around lunar at an inclination of ˜49 degrees, with an orbital height of 100 km and an inter-satellite distance of 200 km. In our research, we simulated the contribution of the KBRR tracking mode for different GRAIL orbital geometries. This analysis indicated possible deficiencies in the low degree coefficient solutions for the polar satellite-to-satellite tracking mode at various orbital heights. We also investigated the potential contributions of the KBRR to the Chang'E-5 mission goal of lunar gravity field recovery, especially in the long wavelength component. Potential improvements were assessed using various power spectrums of the lunar gravity field models. In addition, we also investigated possible improvements in solving lunar tidal Love number K2. These results may assist the implementation of the Chang'E-5 mission.

Who is downloading the free AIDA v4.3a interactive educational diabetes computer software? A 1-year survey of 3864 downloads.

PubMed

Lehmann, Eldon D

2003-01-01

AIDA is a free diabetes computer program that permits the interactive simulation of plasma insulin and blood glucose profiles for educational, demonstration, self-learning, and research purposes. To date over 70000 copies of the software have been downloaded from the AIDA Website, www.2aida.org. This column documents a survey of downloaders of the latest release of the program (AIDA v4.3a). The Internet-based survey methodology was confirmed to be robust and reliable. Over a 1-year period (from March 2001 to February 2002) in total 3864 responses were received. During the corresponding period some 8578 actual downloads of the software were independently logged via the same route at the AIDA Website, giving a response rate for this survey of 45%. Responses were received from participants in 66 countries - over half of these (n = 2,137; 55.3%) were from the United States and the United Kingdom. There were 2318 responses (60.0%) received from patients with diabetes and 443 (11.5%) from relatives of patients, with fewer responses from doctors, students, diabetes educators, nurses, pharmacists, and other end users. This study highlights considerable interest amongst patients and their relatives to learn more about balancing insulin and diet in diabetes, as well as possibly to get more involved in self-management of insulin dosages. More computer applications that can cater for this interest in diabetes patient self-care need to be developed and made available. The Internet provides an ideal medium for the distribution of such educational tools.

PhOD - The Global Drifter Program

Science.gov Websites

February 2018. (As of May 2018). Download all data Subsets of database are also available through February 2018. Download subsets of data Many historical drogue off dates have been reevaluated. As of November buoydata_15001_feb18.dat-gz, dirfl_15001_feb18.dat May 1, 2018: Milestone reached On Tuesday, May 1, 2018, NOAA's

Alternative Fuels Data Center: Maps and Data

Science.gov Websites

acquisitions by fleet type from 1992-2014 Last update August 2016 View Graph Graph Download Data -m8i0e0 Trend of S&FP AFV acquisitions by fuel type from 1992-2015 Last update August 2016 View Graph transactions from 1997-2014 Last update August 2016 View Graph Graph Download Data Generated_thumb20160907

Smithsonian Education - Families - Activity Sheets

Science.gov Websites

United States and design your own flag to represent you! Download and print The True Story of the Star ? See lunch boxes from the Smithsonian and design your own! Download and print It's Pop Culture, Kid Be President (PDF). The True Story of the Star-Spangled Banner The True Story of the Star-Spangled

Alternative Fuels Data Center: Video Download Help

Science.gov Websites

a Windows Media Video (WMV) link and select "Save Target As..." from the shortcut menu. To player on the screen. You can also expand the video to play in full-screen mode using Windows Media played in Windows Media Player. Download Windows Media Player. To watch videos on a Mac, double-click the

Browser-Based Online Applications: Something for Everyone!

ERIC Educational Resources Information Center

Descy, Don E.

2007-01-01

Just as many people log onto a Web mail site (Gmail, Yahoo, MSN, etc.) to read, write and store their email, there are Web sites out there with word processing, database, and a myriad of other software applications that are not downloadable but used on the site through a Web browser. The user does not have to download the applications to a…

Estuary Data Mapper: A Stand-Alone Tool for Geospatial Data Access, Visualization and Download for Estuaries and Coastal Watersheds of the United States

EPA Science Inventory

The US EPA Estuary Data Mapper (EDM; http://badger.epa.gov/rsig/edm/index.html) has been designed as a free stand-alone tool for geospatial data discovery, visualization, and data download for estuaries and their associated watersheds in the conterminous United States. EDM requi...

Estuary Data Mapper: A Stand-Alone Tool for Geospatial Data Access, Visualization and Download for Estuaries and Coastal Watersheds of the United States. (UNH)

EPA Science Inventory

The US EPA Estuary Data Mapper (EDM; http://badger.epa.gov/rsig/edm/index.html) has been designed as a free stand-alone tool for geospatial data discovery, visualization, and data download for estuaries and their associated watersheds in the conterminous United States. EDM requi...

78 FR 78063 - Appendix 4 to Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

...ScienceResearch/UCM334110.pdf . 2. FDA, ``Appendix 4 to Draft Qualitative Risk Assessment of Risk of....regulations.gov and at http://www.fda.gov/downloads/Food/FoodScienceResearch/RiskSafetyAssessment/UCM377408... on a Farm,'' 2013. Available at: http://www.fda.gov/downloads/Food/FoodScienceResearch/RiskSafety...

Walkabout the Galaxy: Podcasting for Informal and Accessible Astronomy Outreach and Education

NASA Astrophysics Data System (ADS)

Colwell, J. E.; Dove, A.; Kehoe, A.; Becker, T. M.

2014-12-01

"Walkabout the Galaxy" is a weekly podcast we have been publishing since May 2014 discussing astronomical news that is in the popular media at the time of recording. Episodes are 25-30 minutes in length and are informal in style: we emphasize one or two basic points while engaging in a free-form discussion of the topic with frequent tangential asides. The target audience is the interested layperson rather than a student, professional, or amateur of astronomy. The informal style is deliberately chosen to keep the podcast from sounding like a classroom lesson and to improve the reach of the podcast to a broader public. Guests have included both experts and laypeople. The number of episode downloads varies by nearly a factor of two from episode to episode (~450 to 750). We will present statistics on downloads and subscriptions, and correlations with episode length, subject matter, and style of episode title. The style of the content cannot influence download statistics, however, and it is not possible to track actual listenership data once the episodes are downloaded. We will discuss lessons learned in creating and producing an educational podcast as well as listener feedback.

CCDST: A free Canadian climate data scraping tool

NASA Astrophysics Data System (ADS)

Bonifacio, Charmaine; Barchyn, Thomas E.; Hugenholtz, Chris H.; Kienzle, Stefan W.

2015-02-01

In this paper we present a new software tool that automatically fetches, downloads and consolidates climate data from a Web database where the data are contained on multiple Web pages. The tool is called the Canadian Climate Data Scraping Tool (CCDST) and was developed to enhance access and simplify analysis of climate data from Canada's National Climate Data and Information Archive (NCDIA). The CCDST deconstructs a URL for a particular climate station in the NCDIA and then iteratively modifies the date parameters to download large volumes of data, remove individual file headers, and merge data files into one output file. This automated sequence enhances access to climate data by substantially reducing the time needed to manually download data from multiple Web pages. To this end, we present a case study of the temporal dynamics of blowing snow events that resulted in ~3.1 weeks time savings. Without the CCDST, the time involved in manually downloading climate data limits access and restrains researchers and students from exploring climate trends. The tool is coded as a Microsoft Excel macro and is available to researchers and students for free. The main concept and structure of the tool can be modified for other Web databases hosting geophysical data.

Automating slope monitoring in mines with terrestrial lidar scanners

NASA Astrophysics Data System (ADS)

Conforti, Dario

2014-05-01

Static terrestrial laser scanners (TLS) have been an important component of slope monitoring for some time, and many solutions for monitoring the progress of a slide have been devised over the years. However, all of these solutions have required users to operate the lidar equipment in the field, creating a high cost in time and resources, especially if the surveys must be performed very frequently. This paper presents a new solution for monitoring slides, developed using a TLS and an automated data acquisition, processing and analysis system. In this solution, a TLS is permanently mounted within sight of the target surface and connected to a control computer. The control software on the computer automatically triggers surveys according to a user-defined schedule, parses data into point clouds, and compares data against a baseline. The software can base the comparison against either the original survey of the site or the most recent survey, depending on whether the operator needs to measure the total or recent movement of the slide. If the displacement exceeds a user-defined safety threshold, the control computer transmits alerts via SMS text messaging and/or email, including graphs and tables describing the nature and size of the displacement. The solution can also be configured to trigger the external visual/audio alarm systems. If the survey areas contain high-traffic areas such as roads, the operator can mark them for exclusion in the comparison to prevent false alarms. To improve usability and safety, the control computer can connect to a local intranet and allow remote access through the software's web portal. This enables operators to perform most tasks with the TLS from their office, including reviewing displacement reports, downloading survey data, and adjusting the scan schedule. This solution has proved invaluable in automatically detecting and alerting users to potential danger within the monitored areas while lowering the cost and work required for monitoring. An explanation of the entire system and a post-acquisition data demonstration will be presented.

Candor Chasma Mesa

NASA Image and Video Library

2003-01-09

In this image from NASA Mars Odyssey, a mantling layer of sediment slumps off the edge of a mesa in Candor Chasma producing a ragged pattern of erosion that hints at the presence of a volatile component mixed in with the sediment.

Soap Bubble Spectra.

ERIC Educational Resources Information Center

Siddons, Colin

1984-01-01

Describes an apparatus (called the "Rainbow Cup") used for demonstrating the colored rings produced by constructive interference in soap films. Discusses construction of the Rainbow Cup and gives hints for its use in the classroom, especially in relation to classroom humidity. (JM)

More Cooperative Games!

ERIC Educational Resources Information Center

Sobel, Jeffrey

1993-01-01

Details instructions for four cooperative games primarily for young children. The games are of low to moderate activity level and involve partners or a group circle. Descriptions include variations of the game and helpful hints for making the game more successful. (KS)

INL Researchers Advance Detection of Brucellosis

ScienceCinema

Roberto, Frank; Newby, Deborah

2017-12-09

What do cattle ranchers in the greater Yellowstone region have in common with British soldiers garrisoned on the island of Malta in the late 1800s? Hint: it's a pathogen that starts with the letter B. It's Brucella Abortus.

INL Researchers Advance Detection of Brucellosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberto, Frank; Newby, Deborah

What do cattle ranchers in the greater Yellowstone region have in common with British soldiers garrisoned on the island of Malta in the late 1800s? Hint: it's a pathogen that starts with the letter B. It's Brucella Abortus.

Hints for the aspiring public health nurse. 1923.

PubMed

Abrams, Sarah E

2010-01-01

The original article from which these excerpts were taken, "Some Hints to the Nurse Who Seeks to Become a Successful Partner in the Community Health Program," by Mary Margaret Muckley, was published the 1923 volume of the original Public Health Nursing journal. The paper listed practical pointers to nurses wanting to work in the area of public or community health nursing. The author's advice involved personal attributes, professional engagement, skills, effective organization, and community relations. Much of the original article contained sound advice for aspirants to nursing work in community settings, but some advice may be considered too idealistic even for this optimistic time period. While the particular references to organizations and agencies existing in Helena, Montana have been omitted, the nurse reading the paper in 1923 had a general guide to her key stakeholders. The excerpts from this paper may give contemporary readers an appreciation of the endurance of what Muckley terms the public health nurse's "Valuable Assets."

Zone routing in a torus network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Dong; Heidelberger, Philip; Kumar, Sameer

A system for routing data in a network comprising a network logic device at a sending node for determining a path between the sending node and a receiving node, wherein the network logic device sets one or more selection bits and one or more hint bits within the data packet, a control register for storing one or more masks, wherein the network logic device uses the one or more selection bits to select a mask from the control register and the network logic device applies the selected mask to the hint bits to restrict routing of the data packet tomore » one or more routing directions for the data packet within the network and selects one of the restricted routing directions from the one or more routing directions and sends the data packet along a link in the selected routing direction toward the receiving node.« less

Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides.

PubMed

Slusarczyk, Magdalena; Ferla, Salvatore; Brancale, Andrea; McGuigan, Christopher

2018-02-01

A new family of thirteen phosphoramidate prodrugs (ProTides) of different 6-substituted-5-fluorouridine nucleoside analogues were synthesized and evaluated as potential anticancer agents. In addition, antiviral activity against Chikungunya (CHIKV) virus was evaluated using a cytopathic effect inhibition assay. Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P-N bond cleavage and free nucleoside 5'-monophosphate delivery. Our observations may support and explain to some extent the poor in vitro biological activity generally demonstrated by the series of 6-substituted-5-fluorouridine phosphoramidates (ProTides) and will be of guidance for the design of novel phosphoramidate prodrugs. Copyright © 2017 Elsevier Ltd. All rights reserved.

Probing dark matter annihilation in the Galaxy with antiprotons and gamma rays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cuoco, Alessandro; Heisig, Jan; Korsmeier, Michael

2017-10-01

A possible hint of dark matter annihilation has been found in Cuoco, Korsmeier and Krämer (2017) from an analysis of recent cosmic-ray antiproton data from AMS-02 and taking into account cosmic-ray propagation uncertainties by fitting at the same time dark matter and propagation parameters. Here, we extend this analysis to a wider class of annihilation channels. We find consistent hints of a dark matter signal with an annihilation cross-section close to the thermal value and with masses in range between 40 and 130 GeV depending on the annihilation channel. Furthermore, we investigate in how far the possible signal is compatiblemore » with the Galactic center gamma-ray excess and recent observation of dwarf satellite galaxies by performing a joint global fit including uncertainties in the dark matter density profile. As an example, we interpret our results in the framework of the Higgs portal model.« less

Zeeman Effect observations toward 36 GHz methanol masers in the Galactic Center

NASA Astrophysics Data System (ADS)

Potvin, Justin A.; Momjian, Emmanuel; Pratim Sarma, Anuj

2017-01-01

We present observations of 36 GHz Class I methanol masers taken with the Karl G. Jansky Very Large Array (VLA) in the B configuration with the aim of detecting the Zeeman Effect. We targeted several 36 GHz Class I methanol masers associated with supernova remnants (SNRs) toward the Galactic Center. Each source was observed in dual circular polarizations for three hours. The observed spectral profiles of the masers are complex, with several components blended in velocity. In only one case was the Stokes V maser profile prominent enough to reveal a 2-sigma hint of a magnetic field of zBlos = 14.56 +/- 5.60 Hz; we have chosen to express our results in terms of zBlos since the Zeeman splitting factor (z) for 36 GHz methanol masers has not been measured. There are several hints that these spectra would reveal significant magnetic fields if they could be spatially and spectrally resolved.

Hint of nonstandard Mikheyev-Smirnov-Wolfenstein dynamics in solar neutrino conversion

NASA Astrophysics Data System (ADS)

Palazzo, Antonio

2011-05-01

Motivated by the recent low-threshold measurements of the solar B8 neutrino spectrum performed by Borexino, Super-Kamiokande and the Sudbury Neutrino Observatory—all now monitoring the transition regime between low-energy (vacuumlike) and high-energy (matter-dominated) flavor conversions—we consider the role of subdominant dynamical terms induced by new flavor-changing interactions. We find that the presence of such perturbations with strength ˜10-1GF is now favored, offering a better description of the anomalous behavior suggested by the new results, whose spectrum shows no sign of the typical low-energy upturn predicted by the standard Mikheyev-Smirnov-Wolfenstein (MSW) mechanism. Our findings, if interpreted in a 2-flavor scheme, provide a hint of such new interactions at the ˜2σ level, which is rather robust with respect to 3-flavor effects possibly induced by nonzero θ13.

MESAFace, a graphical interface to analyze the MESA output

NASA Astrophysics Data System (ADS)

Giannotti, M.; Wise, M.; Mohammed, A.

2013-04-01

MESA (Modules for Experiments in Stellar Astrophysics) has become very popular among astrophysicists as a powerful and reliable code to simulate stellar evolution. Analyzing the output data thoroughly may, however, present some challenges and be rather time-consuming. Here we describe MESAFace, a graphical and dynamical interface which provides an intuitive, efficient and quick way to analyze the MESA output. Catalogue identifier: AEOQ_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEOQ_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 19165 No. of bytes in distributed program, including test data, etc.: 6300592 Distribution format: tar.gz Programming language: Mathematica. Computer: Any computer capable of running Mathematica. Operating system: Any capable of running Mathematica. Tested on Linux, Mac, Windows XP, Windows 7. RAM: Recommended 2 Gigabytes or more. Supplementary material: Additional test data files are available. Classification: 1.7, 14. Nature of problem: Find a way to quickly and thoroughly analyze the output of a MESA run, including all the profiles, and have an efficient method to produce graphical representations of the data. Solution method: We created two scripts (to be run consecutively). The first one downloads all the data from a MESA run and organizes the profiles in order of age. All the files are saved as tables or arrays of tables which can then be accessed very quickly by Mathematica. The second script uses the Manipulate function to create a graphical interface which allows the user to choose what to plot from a set of menus and buttons. The information shown is updated in real time. The user can access very quickly all the data from the run under examination and visualize it with plots and tables. Unusual features: Moving the slides in certain regions may cause an error message. This happens when Mathematica is asked to read nonexistent data. The error message, however, disappears when the slides are moved back. This issue does not preclude the good functioning of the interface. Additional comments: The program uses the dynamical capabilities of Mathematica. When the program is opened, Mathematica prompts the user to “Enable Dynamics”. It is necessary to accept before proceeding. Running time: Depends on the size of the data downloaded, on where the data are stored (hard-drive or web), and on the speed of the computer or network connection. In general, downloading the data may take from a minute to several minutes. Loading directly from the web is slower. For example, downloading a 200 MB data folder (a total of 102 files) with a dual-core Intel laptop, P8700, 2 GB of RAM, at 2.53 GHz took about a minute from the hard-drive and about 23 min from the web (with a basic home wireless connection).

MyOcean Central Information System - Achievements and Perspectives

NASA Astrophysics Data System (ADS)

Claverie, Vincent; Loubrieu, Thomas; Jolibois, Tony; de Dianous, Rémi; Blower, Jon; Romero, Laia; Griffiths, Guy

2013-04-01

Since 2009, MyOcean (http://www.myocean.eu) is providing an operational service, for forecasts, analysis and expertise on ocean currents, temperature, salinity, sea level, primary ecosystems and ice coverage. The production of observation and forecasting data is done by 42 Production Units (PU). Product download and visualisation are hosted by 25 Dissemination Units (DU). All these products and associated services are gathered in a single catalogue hiding the intricate distributed organization of PUs and DUs. Besides applying INSPIRE directive and OGC recommendations, MyOcean overcomes technical choices and challenges. This presentation focuses on 3 specific issues met by MyOcean and relevant for many Spatial Data Infrastructures: user's transaction accounting, large volume download and stream line the catalogue maintenance. Transaction Accounting: Set up powerful means to get detailed knowledge of system usage in order to subsequently improve the products (ocean observations, analysis and forecast dataset) and services (view, download) offer. This subject drives the following ones: Central authentication management for the distributed web services implementations: add-on to THREDDS Data Server for WMS and NETCDF sub-setting service, specific FTP. Share user management with co-funding projects. In addition to MyOcean, alternate projects also need consolidated information about the use of the cofunded products. Provide a central facility for the user management. This central facility provides users' rights to geographically distributed services and gathers transaction accounting history from these distributed services. Propose a user-friendly web interface to download large volume of data (several GigaBytes) as robust as basic FTP but intuitive and file/directory independent. This should rely on a web service drafting the INSPIRE to-be specification and OGC recommendations for download taking into account that FTP server is not enough friendly (need to know filenames, directories) and Web-page not allowing downloading several files. Streamline the maintenance of the central catalogue. The major update for MyOcean v3 (April 2013) is the usage of Geonetwork for catalogue management. This improves the system at different levels : The editing interface is more user-friendly and the catalogue updates are managed in a workflow. This workflow allows higher flexibility for minor updates without giving up the high level qualification requirements for the catalogue content. The distributed web services (download, view) are automatically harvested from the THREDDS Data Server. Thus the manual editing on the catalogue is reduced, the associated typos are avoided and the quality of information is finally improved.

Comparative Impacts of Scala Vestibuli Versus Scala Tympani Cochlear Implantation on Auditory Performances and Programming Parameters in Partially Ossified Cochleae.

PubMed

Trudel, Mathieu; Côté, Mathieu; Philippon, Daniel; Simonyan, David; Villemure-Poliquin, Noémie; Bussières, Richard

2018-07-01

To compare scala vestibuli versus scala tympani cochlear implantation in terms of postoperative auditory performances and programming parameters in patients with severe scala tympani ossification. Retrospective case-control study. Tertiary referral center. One hundred three pediatric and adult patients who underwent cochlear implant surgery between 2000 and 2016. Three groups were formed: a scala vestibuli group, a scala tympani with ossification group, and a scala tympani without ossification group. Patients were matched based on their age, sex, duration of deafness, and side of implantation (ratio of 1:2:2). Postoperative evaluation of auditory performances and programming parameters following intensive functional rehabilitation program completion. Multimedia adaptive test (MAT), hearing in noise test (HINT SNR +10 dB, HINT SNR +5 dB, and HINT SNR +0 dB), impedances, neural response telemetry thresholds (NRT), neural response imaging thresholds (NRI), comfortable levels (C-levels), and threshold levels (T-levels) were compared between groups. Twenty-one patients underwent scala vestibuli cochlear implantation: 19 adults and two children. Auditory performances were similar between groups, although sentence recognition in a noisy environment was slightly higher in the scala vestibuli group. Impedance values were also higher in the scala vestibuli group, but all other programming parameters were similar between groups. We present the largest series of patients with scala vestibuli cochlear implantation. This approach provides at least comparable auditory performances without having any deleterious effects on programming parameters. This viable and useful insertion route might be the primary surgical alternative when facing partial cochlear ossification.

Social Cognition Psychometric Evaluation: Results of the Final Validation Study.

PubMed

Pinkham, Amy E; Harvey, Philip D; Penn, David L

2018-06-06

Social cognition is increasingly recognized as an important treatment target in schizophrenia; however, the dearth of well-validated measures that are suitable for use in clinical trials remains a significant limitation. The Social Cognition Psychometric Evaluation (SCOPE) study addresses this need by systematically evaluating the psychometric properties of promising measures. In this final phase of SCOPE, eight new or modified tasks were evaluated. Stable outpatients with schizophrenia (n = 218) and healthy controls (n = 154) completed the battery at baseline and 2-4 weeks later across three sites. Tasks included the Bell Lysaker Emotion Recognition Task (BLERT), Penn Emotion Recognition Task (ER-40), Reading the Mind in the Eyes Task (Eyes), The Awareness of Social Inferences Test (TASIT), Hinting Task, Mini Profile of Nonverbal Sensitivity (MiniPONS), Social Attribution Task-Multiple Choice (SAT-MC), and Intentionality Bias Task (IBT). BLERT and ER-40 modifications included response time and confidence ratings. The Eyes task was modified to include definitions of terms and TASIT to include response time. Hinting was scored with more stringent criteria. MiniPONS, SAT-MC, and IBT were new to this phase. Tasks were evaluated on (1) test-retest reliability, (2) utility as a repeated measure, (3) relationship to functional outcome, (4) practicality and tolerability, (5) sensitivity to group differences, and (6) internal consistency. Hinting, BLERT, and ER-40 showed the strongest psychometric properties and are recommended for use in clinical trials. Eyes, TASIT, and IBT showed somewhat weaker psychometric properties and require further study. MiniPONS and SAT-MC showed poorer psychometric properties that suggest caution for their use in clinical trials.

Searching for New Physics with b→sτ^{+}τ^{-} Processes.

PubMed

Capdevila, Bernat; Crivellin, Andreas; Descotes-Genon, Sébastien; Hofer, Lars; Matias, Joaquim

2018-05-04

In recent years, intriguing hints for the violation of lepton flavor universality (LFU) have been accumulated in semileptonic B decays, both in the charged-current transitions b→cℓ^{-}ν[over ¯]_{ℓ} (i.e., R_{D}, R_{D^{*}}, and R_{J/ψ}) and the neutral-current transitions b→sℓ^{+}ℓ^{-} (i.e., R_{K} and R_{K^{*}}). Hints for LFU violation in R_{D^{(*)}} and R_{J/ψ} point at large deviations from the standard model (SM) in processes involving tau leptons. Moreover, LHCb has reported deviations from the SM expectations in b→sμ^{+}μ^{-} processes as well as in the ratios R_{K} and R_{K^{*}}, which together point at new physics (NP) affecting muons with a high significance. These hints for NP suggest the possibility of huge LFU-violating effects in b→sτ^{+}τ^{-} transitions. In this Letter, we predict the branching ratios of B→Kτ^{+}τ^{-}, B→K^{*}τ^{+}τ^{-}, and B_{s}→ϕτ^{+}τ^{-}, taking into account NP effects in the Wilson coefficients C_{9(^{'})}^{ττ} and C_{10(^{'})}^{ττ}. Assuming a common NP explanation of R_{D}, R_{D^{(*)}}, and R_{J/ψ}, we show that a very large enhancement of b→sτ^{+}τ^{-} processes, of around 3 orders of magnitude compared to the SM, can be expected under fairly general assumptions. We find that the branching ratios of B_{s}→τ^{+}τ^{-}, B_{s}→ϕτ^{+}τ^{-}, and B→K^{(*)}τ^{+}τ^{-} under these assumptions are in the observable range for LHCb and Belle II.

Hints for cyclical recruitment of atelectasis during ongoing mechanical ventilation in lavage and oleic acid lung injury detected by SpO₂ oscillations and electrical impedance tomography.

PubMed

Bodenstein, Marc; Boehme, Stefan; Wang, Hemei; Duenges, Bastian; Markstaller, Klaus

2014-11-01

Detection of cyclical recruitment of atelectasis after induction of lavage (LAV) or oleic acid injury (OAI) in mechanically ventilated pigs. Primary hypothesis is that oxygen oscillations within the respiratory cycle can be detected by SpO₂ recordings (direct hint). SpO₂ oscillations reflect shunt oscillations that can only be explained by cyclical recruitment of atelectasis. Secondary hypothesis is that electrical impedance tomography (EIT) depicts specific regional changes of lung aeration and of pulmonary mechanical properties (indirect hint). Three groups (each n = 7) of mechanically ventilated pigs were investigated applying above mentioned methods before and repeatedly after induction of lung injury: (1) sham treated animals (SHAM), (2) LAV, and (3) OAI. Early oxygen oscillations occurred in the LAV group (mean calculated amplitude: 73.8 mmHg reflecting shunt oscillation of 11.2% in mean). In the OAI group oxygen oscillations occurred hours after induction of lung injury (mean calculated amplitude: 57.1 mmHg reflecting shunt oscillations of 8.4% in mean). The SHAM group had no relevant oxygen oscillations (<30 mmHg, shunt oscillations < 1.5%). Synchronously to oxygen oscillations, EIT depicted (1) a decrease of ventilation in dorsal areas, (2) an increase in ventral areas, (3) a decrease of especially dependent expiratory impedance, 3) an increase in late inspiratory flow especially in the dependant areas, (4) an increase in the speed of peak expiratory flow (PEF), and (5) a decrease of dorsal late expiratory flow. SpO2 and EIT recordings detect events that are interpreted as cyclical recruitment of atelectasis.

Blogging Is So Last Year--Now Podcasting Is Hot. Online Treasures

ERIC Educational Resources Information Center

Balas, Janet L.

2005-01-01

This column describes the latest innovation in iPod use, podcasts, which are audio files that can be downloaded and played either through a computer or an MP3 player such as an iPod. Because they are feeds, users can subscribe to podcasts and have them downloaded automatically to their computers. The author discusses ways in which podcasts may be…

Community college students conducting experiment

NASA Image and Video Library

2015-01-31

STUDENTS FROM COMMUNITY COLLEGES THROUGHOUT THE SOUTH CAME TOGETHER AT THE U.S. SPACE AND ROCKET CENTER FOR THE BALLOONSAT LAUNCH EVENT. EACH COMMUNITY COLLEGE TEAM ASSEMBLED ITS OWN PAYLOAD, DESIGNED TO DOWNLOAD SCIENTIFIC AND ATMOSPHERIC INFORMATION, AND THEN 2 WEATHER BALLOONS WERE SENT ALOFT TO APPROXIMATELY 100,000 FEET WITH THE PAYLOADS. THE PAYLOADS WERE RECOVERED IN N. GEORGIA AND TAKEN BACK TO THE INDIVIDUAL SCHOOLS FOR DOWNLOADING.

Alternative Fuels Data Center: Kentucky Charges Forward with All-Electric

Science.gov Websites

Partnership. Download QuickTime Video QuickTime (.mov) Download Windows Media Video Windows Media (.wmv) Video Fuel Cell Vehicles in California Nov. 18, 2017 Photo of a car Smart Car Shopping Nov. 4, 2017 Image of Photo of a truck Natural Gas Fuels School Buses and Refuse Trucks in Tulsa, Oklahoma Feb. 18, 2017 Photo

49 CFR 563.7 - Data elements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... cycle, download At time of download 3 N/A Safety belt status, driver −1.0 sec N/A Frontal air bag warning lamp, on/off 2 −1.0 sec N/A Frontal air bag deployment, time to deploy, in the case of a single stage air bag, or time to first stage deployment, in the case of a multi-stage air bag, driver Event N/A...

49 CFR 563.7 - Data elements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... cycle, download At time of download 3 N/A Safety belt status, driver −1.0 sec N/A Frontal air bag warning lamp, on/off 2 −1.0 sec N/A Frontal air bag deployment, time to deploy, in the case of a single stage air bag, or time to first stage deployment, in the case of a multi-stage air bag, driver Event N/A...

49 CFR 563.7 - Data elements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... cycle, download At time of download 3 N/A Safety belt status, driver −1.0 sec N/A Frontal air bag warning lamp, on/off 2 −1.0 sec N/A Frontal air bag deployment, time to deploy, in the case of a single stage air bag, or time to first stage deployment, in the case of a multi-stage air bag, driver Event N/A...

Development of a database system for near-future climate change projections under the Japanese National Project SI-CAT

NASA Astrophysics Data System (ADS)

Nakagawa, Y.; Kawahara, S.; Araki, F.; Matsuoka, D.; Ishikawa, Y.; Fujita, M.; Sugimoto, S.; Okada, Y.; Kawazoe, S.; Watanabe, S.; Ishii, M.; Mizuta, R.; Murata, A.; Kawase, H.

2017-12-01

Analyses of large ensemble data are quite useful in order to produce probabilistic effect projection of climate change. Ensemble data of "+2K future climate simulations" are currently produced by Japanese national project "Social Implementation Program on Climate Change Adaptation Technology (SI-CAT)" as a part of a database for Policy Decision making for Future climate change (d4PDF; Mizuta et al. 2016) produced by Program for Risk Information on Climate Change. Those data consist of global warming simulations and regional downscaling simulations. Considering that those data volumes are too large (a few petabyte) to download to a local computer of users, a user-friendly system is required to search and download data which satisfy requests of the users. We develop "a database system for near-future climate change projections" for providing functions to find necessary data for the users under SI-CAT. The database system for near-future climate change projections mainly consists of a relational database, a data download function and user interface. The relational database using PostgreSQL is a key function among them. Temporally and spatially compressed data are registered on the relational database. As a first step, we develop the relational database for precipitation, temperature and track data of typhoon according to requests by SI-CAT members. The data download function using Open-source Project for a Network Data Access Protocol (OPeNDAP) provides a function to download temporally and spatially extracted data based on search results obtained by the relational database. We also develop the web-based user interface for using the relational database and the data download function. A prototype of the database system for near-future climate change projections are currently in operational test on our local server. The database system for near-future climate change projections will be released on Data Integration and Analysis System Program (DIAS) in fiscal year 2017. Techniques of the database system for near-future climate change projections might be quite useful for simulation and observational data in other research fields. We report current status of development and some case studies of the database system for near-future climate change projections.

Shiftwork Scheduling for the 1990s.

ERIC Educational Resources Information Center

Coleman, Richard M.

1989-01-01

The author discusses the problems of scheduling shift work, touching on such topics as employee desires, health requirements, and business needs. He presents a method for developing shift schedules that addresses these three areas. Implementation hints are also provided. (CH)

Sketchcode: A Documentation Technique for Computer Hobbyists and Programmers

ERIC Educational Resources Information Center

Voros, Todd, L.

1978-01-01

Sketchcode is a metaprograming pseudo-language documentation technique intended to simplify the process of program writing and debugging for both high and low-level users. Helpful hints and examples for the use of the technique are included. (CMV)

Breastfeeding: Hints to Help You Get Off to a Good Start

MedlinePlus

... you can get calcium from foods such as broccoli, sesame seeds, tofu, and kale. Talk to your ... that affect them. These may include spicy foods, broccoli, or milk. Some babies react to cow’s milk ...

Whale Watching in the Gulf of Maine.

ERIC Educational Resources Information Center

Carkin, Clayton A.

1985-01-01

Describes a variety of teaching strategies to prepare a class for a whale watching field trip. Guidelines for recording a sighting, pictures and statistics for commonly and/or occasionally seen whales, and hints for avoiding sea sickness are included. (DH)

Eating Hints: Before, During, and After Cancer Treatment

MedlinePlus

... Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Levels of Evidence: Integrative Therapies Fact Sheets NCI Dictionaries NCI Dictionary of Cancer Terms NCI Drug Dictionary ...

For Caregivers: Coping with Burnout

MedlinePlus

... with ALS and Caregivers ALS Registry Caregivers Assistive Technology for Caregivers Caregiving Tips and Hints The ALS Association Care Connection Coping With Burnout From One Caregiver to Another Respite Care Resources Military Veterans Stories of Courage Newly Diagnosed We’re here for ...

The Best of Practical Pointers.

ERIC Educational Resources Information Center

Association for Research, Administration, Professional Councils & Societies, Reston, VA.

This publication is a compilation of monographs offering practical suggestions for teachers of adapted physical education. It contains numerous suggestions on teaching techniques, activity adaptations, equipment modifications, programming information, coaching hints, skill development strategies, and curriculum data. The five sections offer…

Virtual environment to quantify the influence of colour stimuli on the performance of tasks requiring attention

PubMed Central

2011-01-01

Background Recent studies indicate that the blue-yellow colour discrimination is impaired in ADHD individuals. However, the relationship between colour and performance has not been investigated. This paper describes the development and the testing of a virtual environment that is capable to quantify the influence of red-green versus blue-yellow colour stimuli on the performance of people in a fun and interactive way, being appropriate for the target audience. Methods An interactive computer game based on virtual reality was developed to evaluate the performance of the players. The game's storyline was based on the story of an old pirate who runs across islands and dangerous seas in search of a lost treasure. Within the game, the player must find and interpret the hints scattered in different scenarios. Two versions of this game were implemented. In the first, hints and information boards were painted using red and green colours. In the second version, these objects were painted using blue and yellow colours. For modelling, texturing, and animating virtual characters and objects the three-dimensional computer graphics tool Blender 3D was used. The textures were created with the GIMP editor to provide visual effects increasing the realism and immersion of the players. The games were tested on 20 non-ADHD volunteers who were divided into two subgroups (A1 and A2) and 20 volunteers with ADHD who were divided into subgroups B1 and B2. Subgroups A1 and B1 used the first version of the game with the hints painted in green-red colors, and subgroups A2 and B2 the second version using the same hints now painted in blue-yellow. The time spent to complete each task of the game was measured. Results Data analyzed with ANOVA two-way and posthoc TUKEY LSD showed that the use of blue/yellow instead of green/red colors decreased the game performance of all participants. However, a greater decrease in performance could be observed with ADHD participants where tasks, that require attention, were most affected. Conclusions The game proved to be a user-friendly tool capable to detect and quantify the influence of color on the performance of people executing tasks that require attention and showed to be attractive for people with ADHD. PMID:21854630

Virtual environment to quantify the influence of colour stimuli on the performance of tasks requiring attention.

PubMed

Silva, Alessandro P; Frère, Annie F

2011-08-19

Recent studies indicate that the blue-yellow colour discrimination is impaired in ADHD individuals. However, the relationship between colour and performance has not been investigated. This paper describes the development and the testing of a virtual environment that is capable to quantify the influence of red-green versus blue-yellow colour stimuli on the performance of people in a fun and interactive way, being appropriate for the target audience. An interactive computer game based on virtual reality was developed to evaluate the performance of the players.The game's storyline was based on the story of an old pirate who runs across islands and dangerous seas in search of a lost treasure. Within the game, the player must find and interpret the hints scattered in different scenarios. Two versions of this game were implemented. In the first, hints and information boards were painted using red and green colours. In the second version, these objects were painted using blue and yellow colours. For modelling, texturing, and animating virtual characters and objects the three-dimensional computer graphics tool Blender 3D was used. The textures were created with the GIMP editor to provide visual effects increasing the realism and immersion of the players. The games were tested on 20 non-ADHD volunteers who were divided into two subgroups (A1 and A2) and 20 volunteers with ADHD who were divided into subgroups B1 and B2. Subgroups A1 and B1 used the first version of the game with the hints painted in green-red colors, and subgroups A2 and B2 the second version using the same hints now painted in blue-yellow. The time spent to complete each task of the game was measured. Data analyzed with ANOVA two-way and posthoc TUKEY LSD showed that the use of blue/yellow instead of green/red colors decreased the game performance of all participants. However, a greater decrease in performance could be observed with ADHD participants where tasks, that require attention, were most affected. The game proved to be a user-friendly tool capable to detect and quantify the influence of color on the performance of people executing tasks that require attention and showed to be attractive for people with ADHD.

Using domiciliary non-invasive ventilator data downloads to inform clinical decision-making to optimise ventilation delivery and patient compliance

PubMed Central

Mansell, Stephanie K; Cutts, Steven; Hackney, Isobel; Wood, Martin J; Hawksworth, Kevin; Creer, Dean D; Kilbride, Cherry; Mandal, Swapna

2018-01-01

Introduction Ventilation parameter data from patients receiving home mechanical ventilation can be collected via secure data cards and modem technology. This can then be reviewed by clinicians and ventilator prescriptions adjusted. Typically available measures include tidal volume (VT), leak, respiratory rate, minute ventilation, patient triggered breaths, achieved pressures and patient compliance. This study aimed to assess the potential impact of ventilator data downloads on management of patients requiring home non-invasive ventilation (NIV). Methods A longitudinal within-group design with repeated measurements was used. Baseline ventilator data were downloaded, reviewed and adjustments made to optimise ventilation. Leak, VT and compliance data were collected for comparison at the first review and 3–7 weeks later. Ventilator data were monitored and amended remotely via a modem by a consultant physiotherapist between the first review and second appointment. Results Analysis of data from 52 patients showed increased patient compliance (% days used >4 hours) from 90% to 96% (p=0.007), increased usage from 6.53 to 6.94 hours (p=0.211) and a change in VT(9.4 vs 8.7 mL/kg/ideal body weight, p=0.022). There was no change in leak following review of NIV prescriptions (mean (SD): 43 (23.4) L/min vs 45 (19.9)L/min, p=0.272). Conclusion Ventilator data downloads, via early remote assessment, can help optimise patient ventilation through identification of modifiable factors, in particular interface leak and ventilator prescriptions. However, a prospective study is required to assess whether using ventilator data downloads provides value in terms of patient outcomes and cost-effectiveness. The presented data will help to inform the design of such a study. PMID:29531743

Earth Science Datacasting v2.0

NASA Technical Reports Server (NTRS)

Bingham, Andrew W.; Deen, Robert G.; Hussey, Kevin J.; Stough, Timothy M.; McCleese, Sean W.; Toole, Nicholas T.

2012-01-01

The Datacasting software, which consists of a server and a client, has been developed as part of the Earth Science (ES) Datacasting project. The goal of ES Datacasting is to provide scientists the ability to automatically and continuously download Earth science data that meets a precise, predefined need, and then to instantaneously visualize it on a local computer. This is achieved by applying the concept of podcasting to deliver science data over the Internet using RSS (Really Simple Syndication) XML feeds. By extending the RSS specification, scientists can filter a feed and only download the files that are required for a particular application (for example, only files that contain information about a particular event, such as a hurricane or flood). The extension also provides the ability for the client to understand the format of the data and visualize the information locally. The server part enables a data provider to create and serve basic Datacasting (RSS-based) feeds. The user can subscribe to any number of feeds, view the information related to each item contained within a feed (including browse pre-made images), manually download files associated with items, and place these files in a local store. The client-server architecture enables users to: a) Subscribe and interpret multiple Datacasting feeds (same look and feel as a typical mail client), b) Maintain a list of all items within each feed, c) Enable filtering on the lists based on different metadata attributes contained within the feed (list will reference only data files of interest), d) Visualize the reference data and associated metadata, e) Download files referenced within the list, and f) Automatically download files as new items become available.

Geospatial resources for the geologic community: The USGS National Map

USGS Publications Warehouse

Witt, Emitt C.

2015-01-01

Geospatial data are a key component of investigating, interpreting, and communicating the geological sciences. Locating geospatial data can be time-consuming, which detracts from time spent on a study because these data are not obviously placed in central locations or are served from many disparate databases. The National Map of the US Geological Survey is a publicly available resource for accessing the geospatial base map data needs of the geological community from a central location. The National Map data are available through a viewer and download platform providing access to eight primary data themes, plus the US Topo and scanned historical topographic maps. The eight themes are elevation, orthoimagery, hydrography, geographic names, boundaries, transportation, structures, and land cover, and they are being offered for download as predefined tiles in formats supported by leading geographic information system software. Data tiles are periodically refreshed to capture the most current content and are an efficient method for disseminating and receiving geospatial information. Elevation data, for example, are offered as a download from the National Map as 1° × 1° tiles for the 10- and 30- m products and as 15′ × 15′ tiles for the higher-resolution 3-m product. Vector data sets with smaller file sizes are offered at several tile sizes and formats. Partial tiles are not a download option—any prestaged data that intersect the requesting bounding box will be, in their entirety, part of the download order. While there are many options for accessing geospatial data via the Web, the National Map represents authoritative sources of data that are documented and can be referenced for citation and inclusion in scientific publications. Therefore, National Map products and services should be part of a geologist’s first stop for geospatial information and data.

BP Spill Sampling and Monitoring Data April-September 2010 - Data Download Tool

EPA Pesticide Factsheets

This dataset analyzes waste from the the British Petroleum Deepwater Horizon Rig Explosion Emergency Response, providing opportunity to query data sets by metadata criteria and find resulting raw datasets in CSV format.The data query tool allows users to download air, water and sediment sampling and monitoring data that has been collected in response to the BP oil spill. All sampling and monitoring data that has been collected to date is available for download as raw structured data.The query tools enables CSV file creation to be refined based on the following search criteria: date range (between April 28, 2010 and 9/29/2010); location by zip, city, or county; media (solid waste, weathered oil, air, surface water, liquid waste, tar, sediment, water); substance categories (based on media selection) and substances (based on substance category selection).

Helicopter Fuselage Active Flow Control in the Presence of a Rotor

NASA Technical Reports Server (NTRS)

Martin, Preston B; Overmeyer, Austin D.; Tanner, Philip E.; Wilson, Jacob S.; Jenkins, Luther N.

2014-01-01

This work extends previous investigations of active flow control for helicopter fuselage drag and download reduction to include the effects of the rotor. The development of the new wind tunnel model equipped with fluidic oscillators is explained in terms of the previous test results. Large drag reductions greater than 20% in some cases were measured during powered testing without increasing, and in some cases decreasing download in forward flight. As confirmed by Particle Image Velocimetry (PIV), the optimum actuator configuration that provided a decrease in both drag and download appeared to create a virtual (fluidic) boat-tail fairing instead of attaching flow to the ramp surface. This idea of a fluidic fairing shifts the focus of 3D separation control behind bluff bodies from controlling/reattaching surface boundary layers to interacting with the wake flow.

Data management in automated external defibrillators: a call for a standardised solution.

PubMed

Nielsen, A M; Rasmussen, L S

2011-07-01

The ECG data stored in automated external defibrillators (AEDs) may be valuable for establishing a final diagnosis and deciding further diagnostics and treatment. Different data management systems are used and this may create significant problems for data storage and access for physicians treating victims in whom an AED has been used. In this descriptive study, we collected information (number, manufacturer and model) on 17 December 2010 from a web page used for the voluntary registration of AEDs in Denmark. The manufacturers were contacted and asked to provide information about data downloading. There were 12 different manufactures and 20 different AED models. Five models were registered in a quantity <5. We report data from the remaining 15 models (3603 AEDs). Several models stored only one case or 15 min of ECG data. All models had a data transfer option, but most had outdated 'hardware': Seven had infrared transfer; one had a cable with a serial port. Four had a removable memory device, but only one was a USB. The software was available as freeware only in a few cases. Otherwise, a CD ROM was needed, some even with a licence. The software for the second most common AED could not be installed. The development of data management solutions is not a high priority. We encourage the manufacturers to collaborate with researchers to develop a simple data transfer solution in order to improve patient care and facilitate research. © 2011 The Authors. Acta Anaesthesiologica Scandinavica © 2011 The Acta Anaesthesiologica Scandinavica Foundation.

Abstract shapes of RNA.

PubMed

Giegerich, Robert; Voss, Björn; Rehmsmeier, Marc

2004-01-01

The function of a non-protein-coding RNA is often determined by its structure. Since experimental determination of RNA structure is time-consuming and expensive, its computational prediction is of great interest, and efficient solutions based on thermodynamic parameters are known. Frequently, however, the predicted minimum free energy structures are not the native ones, leading to the necessity of generating suboptimal solutions. While this can be accomplished by a number of programs, the user is often confronted with large outputs of similar structures, although he or she is interested in structures with more fundamental differences, or, in other words, with different abstract shapes. Here, we formalize the concept of abstract shapes and introduce their efficient computation. Each shape of an RNA molecule comprises a class of similar structures and has a representative structure of minimal free energy within the class. Shape analysis is implemented in the program RNAshapes. We applied RNAshapes to the prediction of optimal and suboptimal abstract shapes of several RNAs. For a given energy range, the number of shapes is considerably smaller than the number of structures, and in all cases, the native structures were among the top shape representatives. This demonstrates that the researcher can quickly focus on the structures of interest, without processing up to thousands of near-optimal solutions. We complement this study with a large-scale analysis of the growth behaviour of structure and shape spaces. RNAshapes is available for download and as an online version on the Bielefeld Bioinformatics Server.

Python for Large-Scale Electrophysiology

PubMed Central

Spacek, Martin; Blanche, Tim; Swindale, Nicholas

2008-01-01

Electrophysiology is increasingly moving towards highly parallel recording techniques which generate large data sets. We record extracellularly in vivo in cat and rat visual cortex with 54-channel silicon polytrodes, under time-locked visual stimulation, from localized neuronal populations within a cortical column. To help deal with the complexity of generating and analysing these data, we used the Python programming language to develop three software projects: one for temporally precise visual stimulus generation (“dimstim”); one for electrophysiological waveform visualization and spike sorting (“spyke”); and one for spike train and stimulus analysis (“neuropy”). All three are open source and available for download (http://swindale.ecc.ubc.ca/code). The requirements and solutions for these projects differed greatly, yet we found Python to be well suited for all three. Here we present our software as a showcase of the extensive capabilities of Python in neuroscience. PMID:19198646

Simulating Stable Isotope Ratios in Plumes of Groundwater Pollutants with BIOSCREEN-AT-ISO.

PubMed

Höhener, Patrick; Li, Zhi M; Julien, Maxime; Nun, Pierrick; Robins, Richard J; Remaud, Gérald S

2017-03-01

BIOSCREEN is a well-known simple tool for evaluating the transport of dissolved contaminants in groundwater, ideal for rapid screening and teaching. This work extends the BIOSCREEN model for the calculation of stable isotope ratios in contaminants. A three-dimensional exact solution of the reactive transport from a patch source, accounting for fractionation by first-order decay and/or sorption, is used. The results match those from a previously published isotope model but are much simpler to obtain. Two different isotopes may be computed, and dual isotope plots can be viewed. The dual isotope assessment is a rapidly emerging new approach for identifying process mechanisms in aquifers. Furthermore, deviations of isotope ratios at specific reactive positions with respect to "bulk" ratios in the whole compound can be simulated. This model is named BIOSCREEN-AT-ISO and will be downloadable from the journal homepage. © 2016, National Ground Water Association.

Data, Metadata - Who Cares?

NASA Astrophysics Data System (ADS)

Baumann, Peter

2013-04-01

There is a traditional saying that metadata are understandable, semantic-rich, and searchable. Data, on the other hand, are big, with no accessible semantics, and just downloadable. Not only has this led to an imbalance of search support form a user perspective, but also underneath to a deep technology divide often using relational databases for metadata and bespoke archive solutions for data. Our vision is that this barrier will be overcome, and data and metadata become searchable likewise, leveraging the potential of semantic technologies in combination with scalability technologies. Ultimately, in this vision ad-hoc processing and filtering will not distinguish any longer, forming a uniformly accessible data universe. In the European EarthServer initiative, we work towards this vision by federating database-style raster query languages with metadata search and geo broker technology. We present our approach taken, how it can leverage OGC standards, the benefits envisaged, and first results.

Xi-cam: a versatile interface for data visualization and analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pandolfi, Ronald J.; Allan, Daniel B.; Arenholz, Elke

Xi-cam is an extensible platform for data management, analysis and visualization.Xi-camaims to provide a flexible and extensible approach to synchrotron data treatment as a solution to rising demands for high-volume/high-throughput processing pipelines. The core ofXi-camis an extensible plugin-based graphical user interface platform which provides users with an interactive interface to processing algorithms. Plugins are available for SAXS/WAXS/GISAXS/GIWAXS, tomography and NEXAFS data. WithXi-cam's `advanced' mode, data processing steps are designed as a graph-based workflow, which can be executed live, locally or remotely. Remote execution utilizes high-performance computing or de-localized resources, allowing for the effective reduction of high-throughput data.Xi-cam's plugin-based architecture targetsmore » cross-facility and cross-technique collaborative development, in support of multi-modal analysis.Xi-camis open-source and cross-platform, and available for download on GitHub.« less

Xi-cam: a versatile interface for data visualization and analysis

DOE PAGES

Pandolfi, Ronald J.; Allan, Daniel B.; Arenholz, Elke; ...

2018-05-31

Xi-cam is an extensible platform for data management, analysis and visualization.Xi-camaims to provide a flexible and extensible approach to synchrotron data treatment as a solution to rising demands for high-volume/high-throughput processing pipelines. The core ofXi-camis an extensible plugin-based graphical user interface platform which provides users with an interactive interface to processing algorithms. Plugins are available for SAXS/WAXS/GISAXS/GIWAXS, tomography and NEXAFS data. WithXi-cam's `advanced' mode, data processing steps are designed as a graph-based workflow, which can be executed live, locally or remotely. Remote execution utilizes high-performance computing or de-localized resources, allowing for the effective reduction of high-throughput data.Xi-cam's plugin-based architecture targetsmore » cross-facility and cross-technique collaborative development, in support of multi-modal analysis.Xi-camis open-source and cross-platform, and available for download on GitHub.« less

The semantic measures library and toolkit: fast computation of semantic similarity and relatedness using biomedical ontologies.

PubMed

Harispe, Sébastien; Ranwez, Sylvie; Janaqi, Stefan; Montmain, Jacky

2014-03-01

The semantic measures library and toolkit are robust open-source and easy to use software solutions dedicated to semantic measures. They can be used for large-scale computations and analyses of semantic similarities between terms/concepts defined in terminologies and ontologies. The comparison of entities (e.g. genes) annotated by concepts is also supported. A large collection of measures is available. Not limited to a specific application context, the library and the toolkit can be used with various controlled vocabularies and ontology specifications (e.g. Open Biomedical Ontology, Resource Description Framework). The project targets both designers and practitioners of semantic measures providing a JAVA library, as well as a command-line tool that can be used on personal computers or computer clusters. Downloads, documentation, tutorials, evaluation and support are available at http://www.semantic-measures-library.org.

A Transmission Availability Forecast Service for Internet Protocol Networks

DTIC Science & Technology

1998-12-01

long term changes in the network situation. The probe measurement takes a finite period and so can aggregate and characterise short term variations in...network situation. Nevertheless, the process remains vulnerable to medium term variations, ie changes that occur after the probe and before the download...vulnerable to the medium term changes that might occur between the completion of the examination and the commencement of the download. 3.2 TAF

Image

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marsh, Amber; Harsch, Tim; Pitt, Julie

2007-08-31

The computer side of the IMAGE project consists of a collection of Perl scripts that perform a variety of tasks; scripts are available to insert, update and delete data from the underlying Oracle database, download data from NCBI's Genbank and other sources, and generate data files for download by interested parties. Web scripts make up the tracking interface, and various tools available on the project web-site (image.llnl.gov) that provide a search interface to the database.

PubMed Informer: Monitoring MEDLINE/PubMed through E-mail Alerts, SMS, PDA downloads and RSS feeds

PubMed Central

Muin, Michael; Fontelo, Paul; Ackerman, Michael

2005-01-01

Summary PubMed Informer is a Web-based monitoring tool for topics of interest from MEDLINE/PubMed primarily designed for healthcare professionals. Five tracking methods are available: Web access, e-mail, Short Message Service (SMS), PDA downloads and RSS feeds. PubMed Informer delivers focused search updates and specific information to users with varying information-seeking practices. PMID:16779344

Application of Optical Disc Databases and Related Technology to Public Access Settings

DTIC Science & Technology

1992-03-01

users to download and retain data. A Video Graphics Adapter (VGA) monitor was included. No printer was provided. 2. CD-ROM Product Computer Select, a...download facilities, without printer support, satisfy user needs? 38 A secondary, but significant, objective was avoidance of unnecessary Reader...design of User Log sheets and mitigated against attachment of a printer to the workstation. F. DATA COLLECTION This section describes the methodology

Public accessibility of biomedical articles from PubMed Central reduces journal readership--retrospective cohort analysis.

PubMed

Davis, Philip M

2013-07-01

Does PubMed Central--a government-run digital archive of biomedical articles--compete with scientific society journals? A longitudinal, retrospective cohort analysis of 13,223 articles (5999 treatment, 7224 control) published in 14 society-run biomedical research journals in nutrition, experimental biology, physiology, and radiology between February 2008 and January 2011 reveals a 21.4% reduction in full-text hypertext markup language (HTML) article downloads and a 13.8% reduction in portable document format (PDF) article downloads from the journals' websites when U.S. National Institutes of Health-sponsored articles (treatment) become freely available from the PubMed Central repository. In addition, the effect of PubMed Central on reducing PDF article downloads is increasing over time, growing at a rate of 1.6% per year. There was no longitudinal effect for full-text HTML downloads. While PubMed Central may be providing complementary access to readers traditionally underserved by scientific journals, the loss of article readership from the journal website may weaken the ability of the journal to build communities of interest around research papers, impede the communication of news and events to scientific society members and journal readers, and reduce the perceived value of the journal to institutional subscribers.

Better Living Through Metadata: Examining Archive Usage

NASA Astrophysics Data System (ADS)

Becker, G.; Winkelman, S.; Rots, A.

2013-10-01

The primary purpose of an observatory's archive is to provide access to the data through various interfaces. User interactions with the archive are recorded in server logs, which can be used to answer basic questions like: Who has downloaded dataset X? When did she do this? Which tools did she use? The answers to questions like these fill in patterns of data access (e.g., how many times dataset X has been downloaded in the past three years). Analysis of server logs provides metrics of archive usage and provides feedback on interface use which can be used to guide future interface development. The Chandra X-ray Observatory is fortunate in that a database to track data access and downloads has been continuously recording such transactions for years; however, it is overdue for an update. We will detail changes we hope to effect and the differences the changes may make to our usage metadata picture. We plan to gather more information about the geographic location of users without compromising privacy; create improved archive statistics; and track and assess the impact of web “crawlers” and other scripted access methods on the archive. With the improvements to our download tracking we hope to gain a better understanding of the dissemination of Chandra's data; how effectively it is being done; and perhaps discover ideas for new services.

Hanford Borehole Geologic Information System (HBGIS) Updated User’s Guide for Web-based Data Access and Export

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mackley, Rob D.; Last, George V.; Allwardt, Craig H.

2008-09-24

The Hanford Borehole Geologic Information System (HBGIS) is a prototype web-based graphical user interface (GUI) for viewing and downloading borehole geologic data. The HBGIS is being developed as part of the Remediation Decision Support function of the Soil and Groundwater Remediation Project, managed by Fluor Hanford, Inc., Richland, Washington. Recent efforts have focused on improving the functionality of the HBGIS website in order to allow more efficient access and exportation of available data in HBGIS. Users will benefit from enhancements such as a dynamic browsing, user-driven forms, and multi-select options for selecting borehole geologic data for export. The need formore » translating borehole geologic data into electronic form within the HBGIS continues to increase, and efforts to populate the database continue at an increasing rate. These new web-based tools should help the end user quickly visualize what data are available in HBGIS, select from among these data, and download the borehole geologic data into a consistent and reproducible tabular form. This revised user’s guide supersedes the previous user’s guide (PNNL-15362) for viewing and downloading data from HBGIS. It contains an updated data dictionary for tables and fields containing borehole geologic data as well as instructions for viewing and downloading borehole geologic data.« less

Troubleshooting Micro's.

ERIC Educational Resources Information Center

Black, B. R.

This guide provides instructions for preventive maintenance and for making minor technical adjustments on microcomputers. General hints are provided for all microcomputers concerning static electricity reduction; use of dust covers; heat, magnetic fields, and floppy disks; and the use of halogen fire extinguishers. These are followed by…

In Vitro Spermatogenesis of Gypsy Moth Larvae.

ERIC Educational Resources Information Center

Brown, Judy; Loeb, Marcia J.

1994-01-01

Students establish simple cell developmental cultures to observe the process of spermatogenesis, mitosis, and meiosis in living cells. Using the background information, hints for further exploration, and experimental procedures provided, teachers can easily modify this experiment to suit their students needs. (ZWH)

Mobile Ideas, 1981.

ERIC Educational Resources Information Center

Library Administrator's Council of Northern Illinois, Des Plaines.

This second annual edition, published by the bookmobile librarians of Northern Illinois LACONI-Outreach, provides questions to test bookmobile publicity, an outline of traditional publicity modes, descriptions of bookmobile programs, a discussion of bookmobiles versus books by mail and branch libraries, circulation cost comparisons, hints for…

Helpful Hints: Q and A for Use of the e-TSCA/e-PMN Submission Software

EPA Pesticide Factsheets

The document explains some of the electronic reporting requirements in 40 CFR parts 720, 723 and 725 applicable to documents submitted pursuant to those provisions. The document also discusses recommended practices for such submission.

Discovering Patterns in Interarrival Data

ERIC Educational Resources Information Center

Johnson, Roger W.

2017-01-01

It is suggested that students collect interarrival data for customers arriving at a queue. Two common features will often occur across these various datasets. Some data collection hints, some problems for students to pursue and a few pointers to the literature are given.

Planetary Accretion as Informed by Meteoritic Samples of Early Solar System Planetesimals

NASA Astrophysics Data System (ADS)

Kring, D. A.

2017-08-01

Meteoritic impact melts and impact breccias contain information about the timing and sizes of collisions, which, when augmented with hints about impactor compositions, provide clues about mixing and the dynamical situation in the early solar system.

Practical Hints on Greek and Latin

ERIC Educational Resources Information Center

Jopes, James

1978-01-01

A discussion of some of the difficulties and procedures in translating classical quotations occurring in a modern text. Some of the topics covered are: use of published translations, transliteration from ancient Greek, and non-classical idioms such as medieval and botanical Latin. (AMH)

Fermentation: From Sensory Experience to Conceptual Understanding

ERIC Educational Resources Information Center

Moore, Eugene B.

1977-01-01

Presented is a laboratory exercise that utilizes the natural yeast carbonation method of making homemade root beer to study fermentation and the effect of variables upon the fermentation process. There are photographs, a sample data sheet, and procedural hints included. (Author/MA)

Communicating with the Public: Getting It into Print.

ERIC Educational Resources Information Center

Dyal, Donald

1988-01-01

Discusses the advantages for libraries of utilizing print media for public information and public relations. News releases, interest stories, and feature stories are described, and hints on writing style for each format and on getting items printed are offered. (MES)

A free software for the calculation of T2* values for iron overload assessment.

PubMed

Fernandes, Juliano Lara; Fioravante, Luciana Andrea Barozi; Verissimo, Monica P; Loggetto, Sandra R

2017-06-01

Background Iron overload assessment with magnetic resonance imaging (MRI) using T2* has become a key diagnostic method in the management of many diseases. Quantitative analysis of the MRI images with a cost-effective tool has been a limitation to increased use of the method. Purpose To provide a free software solution for this purpose comparing the results with a commercial solution. Material and Methods The free tool was developed as a standalone program to be directly downloaded and ran in a common personal computer platform without the need of a dedicated workstation. Liver and cardiac T2* values were calculated using both tools and the values obtained compared between them in a group of 56 patients with suspected iron overload using Bland-Altman plots and concordance correlation coefficients (CCC). Results In the heart, the mean T2* differences between the two methods was 0.46 ms (95% confidence interval [CI], -0.037 -0.965) and in the liver 0.49 ms (95% CI, 0.257-0.722). The CCC for both the heart and the liver were significantly high (0.98 [95% CI, 0.966-0.988] with a Pearson ρ of 0.9811 and 0.991 [95% CI, 0.986-0.994] with a Pearson ρ of 0.996, respectively. No significant differences were observed when analyzing only patients with abnormal concentrations of iron in both organs compared to the whole cohort. Conclusion The proposed free software tool is accurate for calculation of T2* values of the liver and heart and might be a solution for centers that cannot use paid commercial solutions.

DASTCOM5: A Portable and Current Database of Asteroid and Comet Orbit Solutions

NASA Astrophysics Data System (ADS)

Giorgini, Jon D.; Chamberlin, Alan B.

2014-11-01

A portable direct-access database containing all NASA/JPL asteroid and comet orbit solutions, with the software to access it, is available for download (ftp://ssd.jpl.nasa.gov/pub/xfr/dastcom5.zip; unzip -ao dastcom5.zip). DASTCOM5 contains the latest heliocentric IAU76/J2000 ecliptic osculating orbital elements for all known asteroids and comets as determined by a least-squares best-fit to ground-based optical, spacecraft, and radar astrometric measurements. Other physical, dynamical, and covariance parameters are included when known. A total of 142 parameters per object are supported within DASTCOM5. This information is suitable for initializing high-precision numerical integrations, assessing orbit geometry, computing trajectory uncertainties, visual magnitude, and summarizing physical characteristics of the body. The DASTCOM5 distribution is updated as often as hourly to include newly discovered objects or orbit solution updates. It includes an ASCII index of objects that supports look-ups based on name, current or past designation, SPK ID, MPC packed-designations, or record number. DASTCOM5 is the database used by the NASA/JPL Horizons ephemeris system. It is a subset exported from a larger MySQL-based relational Small-Body Database ("SBDB") maintained at JPL. The DASTCOM5 distribution is intended for programmers comfortable with UNIX/LINUX/MacOSX command-line usage who need to develop stand-alone applications. The goal of the implementation is to provide small, fast, portable, and flexibly programmatic access to JPL comet and asteroid orbit solutions. The supplied software library, examples, and application programs have been verified under gfortran, Lahey, Intel, and Sun 32/64-bit Linux/UNIX FORTRAN compilers. A command-line tool ("dxlook") is provided to enable database access from shell or script environments.

High Performance Data Distribution for Scientific Community

NASA Astrophysics Data System (ADS)

Tirado, Juan M.; Higuero, Daniel; Carretero, Jesus

2010-05-01

Institutions such as NASA, ESA or JAXA find solutions to distribute data from their missions to the scientific community, and their long term archives. This is a complex problem, as it includes a vast amount of data, several geographically distributed archives, heterogeneous architectures with heterogeneous networks, and users spread around the world. We propose a novel architecture (HIDDRA) that solves this problem aiming to reduce user intervention in data acquisition and processing. HIDDRA is a modular system that provides a highly efficient parallel multiprotocol download engine, using a publish/subscribe policy which helps the final user to obtain data of interest transparently. Our system can deal simultaneously with multiple protocols (HTTP,HTTPS, FTP, GridFTP among others) to obtain the maximum bandwidth, reducing the workload in data server and increasing flexibility. It can also provide high reliability and fault tolerance, as several sources of data can be used to perform one file download. HIDDRA architecture can be arranged into a data distribution network deployed on several sites that can cooperate to provide former features. HIDDRA has been addressed by the 2009 e-IRG Report on Data Management as a promising initiative for data interoperability. Our first prototype has been evaluated in collaboration with the ESAC centre in Villafranca del Castillo (Spain) that shows a high scalability and performance, opening a wide spectrum of opportunities. Some preliminary results have been published in the Journal of Astrophysics and Space Science [1]. [1] D. Higuero, J.M. Tirado, J. Carretero, F. Félix, and A. de La Fuente. HIDDRA: a highly independent data distribution and retrieval architecture for space observation missions. Astrophysics and Space Science, 321(3):169-175, 2009

Idea Bank.

ERIC Educational Resources Information Center

Talesnick, Irwin, Ed.

1984-01-01

Provides innovative ideas in biology, chemistry, and physics on the following topics: enzyme decomposition; chemical waste; time measurement; acid-base color magic; ball bouncing properties; heat; cell theory; and specimen boxes. Materials and procedures are listed when appropriate along with hints for expanding these ideas and investigations. (JM)

Internet Connections to Mathematics Education.

ERIC Educational Resources Information Center

Day, Roger

1995-01-01

Presents Internet connections appropriate for mathematics education; provides descriptions of ways that mathematics educators can access electronic resources such as e-mail, discussion groups, gopher servers, and transfer of files; and provides hints and examples from classroom connections and professional applications. (18 references) (Author/MKR)

NOvA: Exploring Neutrino Mysteries

ScienceCinema

Vahle, Tricia; Messier, Mark

2018-01-16

Neutrinos are a mystery to physicists. They exist in three different flavors and mass states and may be able to give hints about the origins of the matter-dominated universe. A new long-baseline experiment led by Fermilab called NOvA may provide some answers.

EVALUATING DISCONTINUITIES IN COMPLEX SYSTEMS: TOWARD QUANTITATIVE MEASURE OF RESILIENCE

EPA Science Inventory

The textural discontinuity hypothesis (TDH) is based on the observation that animal body mass distributions exhibit discontinuities that may reflect the texture of the landscape available for exploitation. This idea has been extended to other complex systems, hinting that the ide...

User Interface Design for Dynamic Geometry Software

ERIC Educational Resources Information Center

Kortenkamp, Ulrich; Dohrmann, Christian

2010-01-01

In this article we describe long-standing user interface issues with Dynamic Geometry Software and common approaches to address them. We describe first prototypes of multi-touch-capable DGS. We also give some hints on the educational benefits of proper user interface design.

Synergy of a warm spring and dry summer

Treesearch

Yude Pan; David Schimel

2016-01-01

An analysis suggests that high carbon uptake by US land ecosystems during the warm spring of 2012 offset the carbon loss that resulted from severe drought over the summer — and hints that the warm spring could have worsened the drought.

NOvA: Exploring Neutrino Mysteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vahle, Tricia; Messier, Mark

2012-09-06

Neutrinos are a mystery to physicists. They exist in three different flavors and mass states and may be able to give hints about the origins of the matter-dominated universe. A new long-baseline experiment led by Fermilab called NOvA may provide some answers.

Careers in Online: Want Ads in the Online Industry.

ERIC Educational Resources Information Center

Dolan, Donna R.; Hoffman, Laura J.

1984-01-01

Describes sources of job listings in online industry including "New York Times,""Boston Globe,""Washington Post,""Los Angeles Times,""Wall Street Journal,""National Business Employment Weekly," and hints on methods for reading and responding to ads and placing them. Sample advertisements…

Adaptive Intelligent Support to Improve Peer Tutoring in Algebra

ERIC Educational Resources Information Center

Walker, Erin; Rummel, Nikol; Koedinger, Kenneth R.

2014-01-01

Adaptive collaborative learning support (ACLS) involves collaborative learning environments that adapt their characteristics, and sometimes provide intelligent hints and feedback, to improve individual students' collaborative interactions. ACLS often involves a system that can automatically assess student dialogue, model effective and…

Periodic Phenomena In Laser-Ablation Plasma Plumes: A Self-Organization Scenario

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gurlui, S.; Sanduloviciu, M.; Mihesan, C.

2006-01-15

Experimental evidence of the appearance of a proper periodic dynamics in a plasma plume created by pulsed laser ablation is considered as a hint for the presence of a self-organization scenario that explains similar phenomena observed in plasma diodes.

Investigations of Antiangiogenic Mechanisms Using Novel Imaging Techniques

DTIC Science & Technology

2011-02-01

011112-1 Downloaded from SPIE Digital Library on 22 Feb 2010 to 1lular functions that exacerbate treatment resistance and tumor aggressiveness.9 Cycling...measurements, which further complicates ata acquisition and interpretation. Blood flow on the mi- rovessel level has traditionally been measured using laser...34ournal of Biomedical Optics 011112-2 Downloaded from SPIE Digital Library on 22 Feb 2010 to 1The goal of this study was to dynamically image changes in

Quantum information processing with trapped electrons and superconducting electronics (Open Access, Publisher’s Version)

DTIC Science & Technology

2013-07-05

This content has been downloaded from IOPscience. Please scroll down to see the full text. Download details: IP Address: 198.81.129.186 This content...structures with a quadratic nonlinearity, i.e. electrodes with a quadrupolar potential. The pump for this parametric coupling process is a classical...approximation. The system operates as a parametric frequency converter, with the classical drive providing pump photons which allow coherent coupling between

A seasonal comparison of surface sediment characteristics in Chincoteague Bay, Maryland and Virginia, USA

USGS Publications Warehouse

Ellis, Alisha M.; Marot, Marci E.; Wheaton, Cathryn J.; Bernier, Julie C.; Smith, Christopher G.

2016-02-03

This report is an archive for sedimentological data derived from the surface sediment of Chincoteague Bay. Data are available for the spring (March/April 2014) and fall (October 2014) samples collected. Downloadable data are provided as Excel spreadsheets and as JPEG files. Additional files include ArcGIS shapefiles of the sampling sites, detailed results of sediment grain-size analyses, and formal Federal Geographic Data Committee metadata (data downloads).

EPA Facilities and Regional Boundaries Download Package, US, 2012, US EPA, SEGS

EPA Pesticide Factsheets

This downloadable package contains the following layers: EPA facility points, EPA region boundary polygons and EPA region boundary polygons extended to the 200nm Exclusive Economic Zone (EEZ). Included in this package are a file geodatabase (v. 10.0), Esri ArcMap map document (v. 10.0) and XML files for this record and the layer level metadata. This SEGS dataset was produced by EPA Office of Environmental Information (OEI).

Methodically Modeling the Tor Network

DTIC Science & Technology

2012-08-01

relays for their circuits: the choice is weighted by the rela- tive difference in the perceived throughput of each relay in an attempt to balance...network. A lack of details about and justifications for such choices obscures the level of faithfulness to the live network and decreases confidence...first byte of the data payload is shown in (a) and (b), and time to the last byte in (c) and (d), for various download sizes. ping process . File download

STEMonstration: Nutrition

NASA Image and Video Library

2018-05-07

Watch NASA astronaut Scott Tingle demonstrate the importance of astronaut nutrition on the International Space Station! Do you have what it takes to stay healthy in space? Try developing your own astronaut menu by checking out https://www.nasa.gov/stemonstrations for a corresponding lesson plan and see more videos like these! For a high quality copy for download, visit: For a high quality copy for download, visit: https://archive.org/details/jsc2018m000319_STEMonstrations_Nutrition_MXF

KUTE-BASE: storing, downloading and exporting MIAME-compliant microarray experiments in minutes rather than hours.

PubMed

Draghici, Sorin; Tarca, Adi L; Yu, Longfei; Ethier, Stephen; Romero, Roberto

2008-03-01

The BioArray Software Environment (BASE) is a very popular MIAME-compliant, web-based microarray data repository. However in BASE, like in most other microarray data repositories, the experiment annotation and raw data uploading can be very timeconsuming, especially for large microarray experiments. We developed KUTE (Karmanos Universal daTabase for microarray Experiments), as a plug-in for BASE 2.0 that addresses these issues. KUTE provides an automatic experiment annotation feature and a completely redesigned data work-flow that dramatically reduce the human-computer interaction time. For instance, in BASE 2.0 a typical Affymetrix experiment involving 100 arrays required 4 h 30 min of user interaction time forexperiment annotation, and 45 min for data upload/download. In contrast, for the same experiment, KUTE required only 28 min of user interaction time for experiment annotation, and 3.3 min for data upload/download. http://vortex.cs.wayne.edu/kute/index.html.

Web processing service for landslide hazard assessment

NASA Astrophysics Data System (ADS)

Sandric, I.; Ursaru, P.; Chitu, D.; Mihai, B.; Savulescu, I.

2012-04-01

Hazard analysis requires heavy computation and specialized software. Web processing services can offer complex solutions that can be accessed through a light client (web or desktop). This paper presents a web processing service (both WPS and Esri Geoprocessing Service) for landslides hazard assessment. The web processing service was build with Esri ArcGIS Server solution and Python, developed using ArcPy, GDAL Python and NumPy. A complex model for landslide hazard analysis using both predisposing and triggering factors combined into a Bayesian temporal network with uncertainty propagation was build and published as WPS and Geoprocessing service using ArcGIS Standard Enterprise 10.1. The model uses as predisposing factors the first and second derivatives from DEM, the effective precipitations, runoff, lithology and land use. All these parameters can be served by the client from other WFS services or by uploading and processing the data on the server. The user can select the option of creating the first and second derivatives from the DEM automatically on the server or to upload the data already calculated. One of the main dynamic factors from the landslide analysis model is leaf area index. The LAI offers the advantage of modelling not just the changes from different time periods expressed in years, but also the seasonal changes in land use throughout a year. The LAI index can be derived from various satellite images or downloaded as a product. The upload of such data (time series) is possible using a NetCDF file format. The model is run in a monthly time step and for each time step all the parameters values, a-priory, conditional and posterior probability are obtained and stored in a log file. The validation process uses landslides that have occurred during the period up to the active time step and checks the records of the probabilities and parameters values for those times steps with the values of the active time step. Each time a landslide has been positive identified new a-priory probabilities are recorded for each parameter. A complete log for the entire model is saved and used for statistical analysis and a NETCDF file is created and it can be downloaded from the server with the log file

Soil organic carbon loss and selective transportation under field simulated rainfall events.

PubMed

Nie, Xiaodong; Li, Zhongwu; Huang, Jinquan; Huang, Bin; Zhang, Yan; Ma, Wenming; Hu, Yanbiao; Zeng, Guangming

2014-01-01

The study on the lateral movement of soil organic carbon (SOC) during soil erosion can improve the understanding of global carbon budget. Simulated rainfall experiments on small field plots were conducted to investigate the SOC lateral movement under different rainfall intensities and tillage practices. Two rainfall intensities (High intensity (HI) and Low intensity (LI)) and two tillage practices (No tillage (NT) and Conventional tillage (CT)) were maintained on three plots (2 m width × 5 m length): HI-NT, LI-NT and LI-CT. The rainfall lasted 60 minutes after the runoff generated, the sediment yield and runoff volume were measured and sampled at 6-min intervals. SOC concentration of sediment and runoff as well as the sediment particle size distribution were measured. The results showed that most of the eroded organic carbon (OC) was lost in form of sediment-bound organic carbon in all events. The amount of lost SOC in LI-NT event was 12.76 times greater than that in LI-CT event, whereas this measure in HI-NT event was 3.25 times greater than that in LI-NT event. These results suggest that conventional tillage as well as lower rainfall intensity can reduce the amount of lost SOC during short-term soil erosion. Meanwhile, the eroded sediment in all events was enriched in OC, and higher enrichment ratio of OC (ERoc) in sediment was observed in LI events than that in HI event, whereas similar ERoc curves were found in LI-CT and LI-NT events. Furthermore, significant correlations between ERoc and different size sediment particles were only observed in HI-NT event. This indicates that the enrichment of OC is dependent on the erosion process, and the specific enrichment mechanisms with respect to different erosion processes should be studied in future.

Soil Organic Carbon Loss and Selective Transportation under Field Simulated Rainfall Events

PubMed Central

Nie, Xiaodong; Li, Zhongwu; Huang, Jinquan; Huang, Bin; Zhang, Yan; Ma, Wenming; Hu, Yanbiao; Zeng, Guangming

2014-01-01

The study on the lateral movement of soil organic carbon (SOC) during soil erosion can improve the understanding of global carbon budget. Simulated rainfall experiments on small field plots were conducted to investigate the SOC lateral movement under different rainfall intensities and tillage practices. Two rainfall intensities (High intensity (HI) and Low intensity (LI)) and two tillage practices (No tillage (NT) and Conventional tillage (CT)) were maintained on three plots (2 m width × 5 m length): HI-NT, LI-NT and LI-CT. The rainfall lasted 60 minutes after the runoff generated, the sediment yield and runoff volume were measured and sampled at 6-min intervals. SOC concentration of sediment and runoff as well as the sediment particle size distribution were measured. The results showed that most of the eroded organic carbon (OC) was lost in form of sediment-bound organic carbon in all events. The amount of lost SOC in LI-NT event was 12.76 times greater than that in LI-CT event, whereas this measure in HI-NT event was 3.25 times greater than that in LI-NT event. These results suggest that conventional tillage as well as lower rainfall intensity can reduce the amount of lost SOC during short-term soil erosion. Meanwhile, the eroded sediment in all events was enriched in OC, and higher enrichment ratio of OC (ERoc) in sediment was observed in LI events than that in HI event, whereas similar ERoc curves were found in LI-CT and LI-NT events. Furthermore, significant correlations between ERoc and different size sediment particles were only observed in HI-NT event. This indicates that the enrichment of OC is dependent on the erosion process, and the specific enrichment mechanisms with respect to different erosion processes should be studied in future. PMID:25166015

Small strokes causing severe vertigo: frequency of false-negative MRIs and nonlacunar mechanisms.

PubMed

Saber Tehrani, Ali S; Kattah, Jorge C; Mantokoudis, Georgios; Pula, John H; Nair, Deepak; Blitz, Ari; Ying, Sarah; Hanley, Daniel F; Zee, David S; Newman-Toker, David E

2014-07-08

Describe characteristics of small strokes causing acute vestibular syndrome (AVS). Ambispective cross-sectional study of patients with AVS (acute vertigo or dizziness, nystagmus, nausea/vomiting, head-motion intolerance, unsteady gait) with at least one stroke risk factor from 1999 to 2011 at a single stroke referral center. Patients underwent nonquantitative HINTS "plus" examination (head impulse, nystagmus, test-of-skew plus hearing), neuroimaging to confirm diagnoses (97% by MRI), and repeat MRI in those with initially normal imaging but clinical signs of a central lesion. We identified patients with diffusion-weighted imaging (DWI) strokes ≤10 mm in axial diameter. Of 190 high-risk AVS presentations (105 strokes), we found small strokes in 15 patients (median age 64 years, range 41-85). The most common vestibular structure infarcted was the inferior cerebellar peduncle (73%); the most common stroke location was the lateral medulla (60%). Focal neurologic signs were present in only 27%. The HINTS "plus" battery identified small strokes with greater sensitivity than early MRI-DWI (100% vs 47%, p < 0.001). False-negative initial MRIs (6-48 hours) were more common with small strokes than large strokes (53% [n = 8/15] vs 7.8% [n = 7/90], p < 0.001). Nonlacunar stroke mechanisms were responsible in 47%, including 6 vertebral artery occlusions or dissections. Small strokes affecting central vestibular projections can present with isolated AVS. The HINTS "plus" hearing battery identifies these patients with greater accuracy than early MRI-DWI, which is falsely negative in half, up to 48 hours after onset. We found nonlacunar mechanisms in half, suggesting greater risk than might otherwise be assumed for patients with such small infarctions. © 2014 American Academy of Neurology.

seismo-live: Training in Computational Seismology using Jupyter Notebooks

NASA Astrophysics Data System (ADS)

Igel, H.; Krischer, L.; van Driel, M.; Tape, C.

2016-12-01

Practical training in computational methodologies is still underrepresented in Earth science curriculae despite the increasing use of sometimes highly sophisticated simulation technologies in research projects. At the same time well-engineered community codes make it easy to return simulation-based results yet with the danger that the inherent traps of numerical solutions are not well understood. It is our belief that training with highly simplified numerical solutions (here to the equations describing elastic wave propagation) with carefully chosen elementary ingredients of simulation technologies (e.g., finite-differencing, function interpolation, spectral derivatives, numerical integration) could substantially improve this situation. For this purpose we have initiated a community platform (www.seismo-live.org) where Python-based Jupyter notebooks can be accessed and run without and necessary downloads or local software installations. The increasingly popular Jupyter notebooks allow combining markup language, graphics, equations with interactive, executable python codes. We demonstrate the potential with training notebooks for the finite-difference method, pseudospectral methods, finite/spectral element methods, the finite-volume and the discontinuous Galerkin method. The platform already includes general Python training, introduction to the ObsPy library for seismology as well as seismic data processing and noise analysis. Submission of Jupyter notebooks for general seismology are encouraged. The platform can be used for complementary teaching in Earth Science courses on compute-intensive research areas.

Distributed Finite Element Analysis Using a Transputer Network

NASA Technical Reports Server (NTRS)

Watson, James; Favenesi, James; Danial, Albert; Tombrello, Joseph; Yang, Dabby; Reynolds, Brian; Turrentine, Ronald; Shephard, Mark; Baehmann, Peggy

1989-01-01

The principal objective of this research effort was to demonstrate the extraordinarily cost effective acceleration of finite element structural analysis problems using a transputer-based parallel processing network. This objective was accomplished in the form of a commercially viable parallel processing workstation. The workstation is a desktop size, low-maintenance computing unit capable of supercomputer performance yet costs two orders of magnitude less. To achieve the principal research objective, a transputer based structural analysis workstation termed XPFEM was implemented with linear static structural analysis capabilities resembling commercially available NASTRAN. Finite element model files, generated using the on-line preprocessing module or external preprocessing packages, are downloaded to a network of 32 transputers for accelerated solution. The system currently executes at about one third Cray X-MP24 speed but additional acceleration appears likely. For the NASA selected demonstration problem of a Space Shuttle main engine turbine blade model with about 1500 nodes and 4500 independent degrees of freedom, the Cray X-MP24 required 23.9 seconds to obtain a solution while the transputer network, operated from an IBM PC-AT compatible host computer, required 71.7 seconds. Consequently, the $80,000 transputer network demonstrated a cost-performance ratio about 60 times better than the $15,000,000 Cray X-MP24 system.

DOCKSCORE: a webserver for ranking protein-protein docked poses.

PubMed

Malhotra, Sony; Mathew, Oommen K; Sowdhamini, Ramanathan

2015-04-24

Proteins interact with a variety of other molecules such as nucleic acids, small molecules and other proteins inside the cell. Structure-determination of protein-protein complexes is challenging due to several reasons such as the large molecular weights of these macromolecular complexes, their dynamic nature, difficulty in purification and sample preparation. Computational docking permits an early understanding of the feasibility and mode of protein-protein interactions. However, docking algorithms propose a number of solutions and it is a challenging task to select the native or near native pose(s) from this pool. DockScore is an objective scoring scheme that can be used to rank protein-protein docked poses. It considers several interface parameters, namely, surface area, evolutionary conservation, hydrophobicity, short contacts and spatial clustering at the interface for scoring. We have implemented DockScore in form of a webserver for its use by the scientific community. DockScore webserver can be employed, subsequent to docking, to perform scoring of the docked solutions, starting from multiple poses as inputs. The results, on scores and ranks for all the poses, can be downloaded as a csv file and graphical view of the interface of best ranking poses is possible. The webserver for DockScore is made freely available for the scientific community at: http://caps.ncbs.res.in/dockscore/ .

On Thermodiffusion and Gauge Transformations for Thermodynamic Fluxes and Driving Forces

NASA Astrophysics Data System (ADS)

Goldobin, D. S.

2017-12-01

We discuss the molecular diffusion transport in infinitely dilute liquid solutions under nonisothermal conditions. This discussion is motivated by an occurring misinterpretation of thermodynamic transport equations written in terms of chemical potential in the presence of temperature gradient. The transport equations contain the contributions owned by a gauge transformation related to the fact that chemical potential is determined up to the summand of form ( AT + B) with arbitrary constants A and B, where constant A is owned by the entropy invariance with respect to shifts by a constant value and B is owned by the potential energy invariance with respect to shifts by a constant value. The coefficients of the cross-effect terms in thermodynamic fluxes are contributed by this gauge transformation and, generally, are not the actual cross-effect physical transport coefficients. Our treatment is based on consideration of the entropy balance and suggests a promising hint for attempts of evaluation of the thermal diffusion constant from the first principles. We also discuss the impossibility of the "barodiffusion" for dilute solutions, understood in a sense of diffusion flux driven by the pressure gradient itself. When one speaks of "barodiffusion" terms in literature, these terms typically represent the drift in external potential force field (e.g., electric or gravitational fields), where in the final equations the specific force on molecules is substituted with an expression with the hydrostatic pressure gradient this external force field produces. Obviously, the interpretation of the latter as barodiffusion is fragile and may hinder the accounting for the diffusion fluxes produced by the pressure gradient itself.

Plasma protein adsorption to zwitterionic poly (carboxybetaine methacrylate) modified surfaces: chain chemistry and end-group effects on protein adsorption kinetics, adsorbed amounts and immunoblots.

PubMed

Abraham, Sinoj; Bahniuk, Markian S; Unsworth, Larry D

2012-12-01

Protein-surface interactions are crucial to the overall biocompatability of biomaterials, and are thought to be the impetus towards the adverse host responses such as blood coagulation and complement activation. Only a few studies hint at the ultra-low fouling potential of zwitterionic poly(carboxybetaine methacrylate) (PCBMA) grafted surfaces and, of those, very few systematically investigate their non-fouling behavior. In this work, single protein adsorption studies as well as protein adsorption from complex solutions (i.e. human plasma) were used to evaluate the non-fouling potential of PCBMA grafted silica wafers prepared by nitroxide-mediated free radical polymerization. PCBMAs used for surface grafting varied in charge separating spacer groups that influence the overall surface charges, and chain end-groups that influence the overall hydrophilicity, thereby, allows a better understanding of these effects towards the protein adsorption for these materials. In situ ellipsometry was used to quantify the adsorbed layer thickness and adsorption kinetics for the adsorption of four proteins from single protein buffer solutions, viz, lysozyme, α-lactalbumin, human serum albumin and fibrinogen. Total amount of protein adsorbed on surfaces differed as a function of surface properties and protein characteristics. Finally, immunoblots results showed that human plasma protein adsorption to these surfaces resulted, primarily, in the adsorption of human serum albumin, with total protein adsorbed amounts being the lowest for PCBMA-3 (TEMPO). It was apparent that surface charge and chain hydrophilicity directly influenced protein adsorption behavior of PCBMA systems and are promising materials for biomedical applications.