Astrophysical interpretation of the anisotropies in the unresolved gamma-ray background

NASA Astrophysics Data System (ADS)

Ando, Shin'ichiro; Fornasa, Mattia; Fornengo, Nicolao; Regis, Marco; Zechlin, Hannes-S.

2017-06-01

Recently, a new measurement of the auto- and cross-correlation angular power spectrum (APS) of the isotropic gamma-ray background was performed, based on 81 months of data of the Fermi Large-Area Telescope (LAT). Here, we fit, for the first time, the new APS data with a model describing the emission of unresolved blazars. These sources are expected to dominate the anisotropy signal. The model we employ in our analysis reproduces well the blazars resolved by Fermi LAT. When considering the APS obtained by masking the sources listed in the 3FGL catalog, we find that unresolved blazars underproduce the measured APS below ˜1 GeV . Contrary to past results, this suggests the presence of a new contribution to the low-energy APS, with a significance of, at least, 5 σ . The excess can be ascribed to a new class of faint gamma-ray emitters. If we consider the APS obtained by masking the sources in the 2FGL catalog, there is no underproduction of the APS below 1 GeV, but the new source class is still preferred over the blazars-only scenario (with a significance larger than 10 σ ). The properties of the new source class and the level of anisotropies induced in the isotropic gamma-ray background are the same, independent of the APS data used. In particular, the new gamma-ray emitters must have a soft energy spectrum, with a spectral index ranging, approximately, from 2.7 to 3.2. This complicates their interpretation in terms of known sources, since, normally, star-forming and radio galaxies are observed with a harder spectrum. The new source class identified here is also expected to contribute significantly to the intensity of the isotropic gamma-ray background.

Study of solid rocket motors for a space shuttle booster. Appendix E: Environmental impact statement, solid rocket motor, space shuttle booster

NASA Technical Reports Server (NTRS)

1972-01-01

An analysis of the combustion products resulting from the solid propellant rocket engines of the space shuttle booster is presented. Calculation of the degree of pollution indicates that the only potentially harmful pollutants, carbon monoxide and hydrochloric acid, will be too diluted to constitute a hazard. The mass of products ejected during a launch within the troposphere is insignificant in terms of similar materials that enter the atmosphere from other sources. Noise pollution will not exceed that obtained from the Saturn 5 launch vehicle.

Stanford Synchrotron Radiation Laboratory activity report for 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cantwell, K.

1987-12-31

1986 was another year of major advances for SSRL as the ultimate capabilities of PEP as a synchrotron radiation source became more apparent and a second PEP beam line was initiated, while effective development and utilization of SPEAR proceeded. Given these various PEP developments, SSRL abandoned its plans for a separate diffraction limited ring, as they abandoned their plans for a 6--7 GeV ring of the APS type last year. It has become increasingly apparent that SSRL should concentrate on developing SPEAR and PEP as synchrotron radiation sources. Consequently, initial planning for a 3 GeV booster synchrotron injector for SPEARmore » was performed in 1986, with a proposal to the Department of Energy resulting. As described in Chapter 2, the New Rings Group and the Machine Physics Group were combined into one Accelerator Physics Group. This group is focusing mainly on the improvement of SPEAR`s operating conditions and on planning for the conversion of PEP into a fourth generation x-ray source. Considerable emphasis is also being given to the training of accelerator physics graduate students. At the same time, several improvements of SSRL`s existing facilities were made. These are described in Chapter 3. Chapter 4 describes new SSRL beam lines being commissioned. Chapter 5 discusses SSRL`s present construction projects. Chapter 6 discusses a number of projects presently underway in the engineering division. Chapter 7 describes SSRL`s advisory panels while Chapter 8 discusses SSRL`s overall organization. Chapter 9 describes the experimental progress reports.« less

VizieR Online Data Catalog: Catalog of 316 K giant candidates (Rebull+, 2015)

NASA Astrophysics Data System (ADS)

Rebull, L. M.; Carlberg, J. K.; Gibbs, J. C.; Deeb, J. E.; Larsen, E.; Black, D. V.; Altepeter, S.; Bucksbee, E.; Cashen, S.; Clarke, M.; Datta, A.; Hodgson, E.; Lince, M.

2015-11-01

There are 82 targets published in de la Reza et al. (1997ApJ...482L..77D). There are 86 K giants reported in Carlberg et al. 2012 (cat. J/ApJ/757/109). We compiled 149 additional targets that have been identified either consistently or at one time as confirmed or possible Li-rich K giants, but not included in either the de la Reza et al. (1997ApJ...482L..77D) or the Carlberg et al. 2012 (cat. J/ApJ/757/109) samples. They include targets from Adamow et al. 2014 (cat. J/A+A/569/A55), Anthony-Twarog et al. (2013ApJ...767L..19A), Carney et al. (1998AJ....116.2984C), Carlberg et al. (2015ApJ...802....7C), Castilho et al. 2000 (cat. J/A+A/364/674), Drake et al. (2002AJ....123.2703D), Fekel & Watson (1998AJ....116.2466F), Hill & Pasquini (1999A&A...348L..21H), Jasniewicz et al. (1999A&A...342..831J), Kirby et al. (2012ApJ...752L..16K), Kraft et al. (1999ApJ...518L..53K), Kumar et al. (2011ApJ...730L..12K) and references therein, Liu et al. (2014ApJ...785...94L), Luck & Heiter 2007 (cat. J/AJ/133/2464), Martell & Shetrone (2013MNRAS.430..611M), Monaco et al. (2014A&A...564L...6M), Pilachowski et al. (2003AJ....125..794P), Ruchti et al. (2011ApJ...743..107R), Silva Aguirre et al. (2014ApJ...784L..16A), Smith et al. (1999ApJ...516L..73S), and Torres et al. (2000IAUS..198..320T). Our complete list of 316 targets with position, photometric, and abundance data appears in Table1. We obtained positions for these targets, most of which are quite bright in the optical, primarily from SIMBAD, though literature was consulted for fainter sources as required. Detailed notes on the sources we suspect are subject to source confusion appear in Table4. Table6 contains notes on the entire set of sources. (3 data files).

Inviscid and Viscous CFD Analysis of Booster Separation for the Space Launch System Vehicle

NASA Technical Reports Server (NTRS)

Dalle, Derek J.; Rogers, Stuart E.; Chan, William M.; Lee, Henry C.

2016-01-01

This paper presents details of Computational Fluid Dynamic (CFD) simulations of the Space Launch System during solid-rocket booster separation using the Cart3D inviscid and Overflow viscous CFD codes. The discussion addresses the use of multiple data sources of computational aerodynamics, experimental aerodynamics, and trajectory simulations for this critical phase of flight. Comparisons are shown between Cart3D simulations and a wind tunnel test performed at NASA Langley Research Center's Unitary Plan Wind Tunnel, and further comparisons are shown between Cart3D and viscous Overflow solutions for the flight vehicle. The Space Launch System (SLS) is a new exploration-class launch vehicle currently in development that includes two Solid Rocket Boosters (SRBs) modified from Space Shuttle hardware. These SRBs must separate from the SLS core during a phase of flight where aerodynamic loads are nontrivial. The main challenges for creating a separation aerodynamic database are the large number of independent variables (including orientation of the core, relative position and orientation of the boosters, and rocket thrust levels) and the complex flow caused by exhaust plumes of the booster separation motors (BSMs), which are small rockets designed to push the boosters away from the core by firing partially in the direction opposite to the motion of the vehicle.

An overview of Booster and AGS polarized proton operation during Run 15

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeno, K.

2015-10-20

This note is an overview of the Booster and AGS for the 2015 Polarized Proton RHIC run from an operations perspective. There are some notable differences between this and previous runs. In particular, the polarized source intensity was expected to be, and was, higher this year than in previous RHIC runs. The hope was to make use of this higher input intensity by allowing the beam to be scraped down more in the Booster to provide a brighter and smaller beam for the AGS and RHIC. The RHIC intensity requirements were also higher this run than in previous runs, whichmore » caused additional challenges because the AGS polarization and emittance are normally intensity dependent.« less

Fermilab Booster Transition Crossing Simulations and Beam Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, C. M.; Tan, C. Y.

2016-01-01

The Fermilab Booster accelerates beam from 400 MeV to 8 GeV at 15 Hz. In the PIP (Proton Improvement Plan) era, it is required that Booster deliver 4.2 xmore » $$10^{12}$$ protons per pulse to extraction. One of the obstacles for providing quality beam to the users is the longitudinal quadrupole oscillation that the beam suffers from right after transition. Although this oscillation is well taken care of with quadrupole dampers, it is important to understand the source of these oscillations in light of the PIP II requirements that require 6.5 x $$10^{12}$$ protons per pulse at extraction. This paper explores the results from machine studies, computer simulations and solutions to prevent the quadrupole oscillations after transition.« less

An analysis of booster tone noise using a time-linearized Navier-Stokes solver

NASA Astrophysics Data System (ADS)

Wukie, Nathan A.

This thesis details a computational investigation of tone noise generated from a booster(low-pressure compressor) in a fan test rig. The computational study consisted of sets of time-linearized Navier-Stokes simulations in the booster region to investigate the blade-wake interactions that act as the primary noise-generating mechanism for the booster blade-passing frequency and harmonics. An acoustic test database existed with data at several operating points for the fan test rig that was used to compare against the predicted noise data from the computational study. It is shown that the computational methodology is able to capture trends in sound power for the 1st and 2nd booster tones along the operating line for the rig. It is also shown that the computational study underpredicts one of the tones at low power and is not able to capture a peak in the data at the Cutback condition. Further investigation of this type is warranted to quantify the source of discrepancies between the computational and experimental data as the reflected transmisison of sound off the fan through the bypass duct was not accounted for in this study.

Palynological Investigation of Post-Flight Solid Rocket Booster Foreign Material

NASA Technical Reports Server (NTRS)

Nelson, Linda; Jarzen, David

2008-01-01

Investigations of foreign material in a drain tube, from the Solid Rocket Booster (SRB) of a recent Space Shuttle mission, was identified as pollen. The source of the pollen is from deposits made by bees, collecting pollen from plants found at the Kennedy Space Center, Cape Canaveral, Florida. The pollen is determined to have been present in the frustum drain tubes before the shuttle flight. During the flight the pollen did not undergo thermal maturation.

Engine protection system for recoverable rocket booster

NASA Technical Reports Server (NTRS)

Shelby, Jr., Jerry A. (Inventor)

1994-01-01

A rocket engine protection system for a recoverable rocket booster which is arranged to land in a salt water body in substantially a nose down attitude. The system includes an inflatable bag which is stowed on a portion of a flat annular rim of the aft skirt of the booster. The bag is hinged at opposing sides and is provided with springs that urge the bag open. The bag is latched in a stowed position during launch and prior to landing for recovery is unlatched to permit the bag to be urged open and into sealing engagement with the rim. A source of pressurized gas further inflates the bag and urges it into sealing engagement with the rim of the skirt where it is locked into position. The gas provides a positive pressure upon the interior of the bag to preclude entry of salt water into the skirt and into contact with the engine. A flotation arrangement may assist in precluding the skirt of the booster from becoming submerged.

Analysis of the AP-42, supplement 5 emission model.

DOT National Transportation Integrated Search

1976-01-01

This report examines the performance of the source strength model presented in the U.S. Environmental Protection Agency publication AP-42, Supplement 5 relative to field data gathered during the AIRPOL project and relative to the previous source stre...

Acellular vaccines for preventing whooping cough in children.

PubMed

Zhang, Linjie; Prietsch, Sílvio O M; Axelsson, Inge; Halperin, Scott A

2012-03-14

Routine use of whole-cell pertussis (wP) vaccines was suspended in some countries in the 1970s and 1980s because of concerns about adverse effects. Following such action, there was a resurgence of whooping cough. Acellular pertussis (aP) vaccines, containing purified or recombinant Bordetella pertussis (B. pertussis) antigens, were developed in the hope that they would be as effective, but less reactogenic than the whole-cell vaccines. To assess the efficacy and safety of acellular pertussis vaccines in children. We searched the Cochrane Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4) which contains the Cochrane Acute Respiratory Infections Group's Specialised Register, MEDLINE (1950 to December week 4, 2011), EMBASE (1974 to January 2012), Biosis Previews (2009 to January 2012), and CINAHL (2009 to January 2012). We selected double-blind randomised efficacy and safety trials of aP vaccines in children up to six years old, with active follow-up of participants and laboratory verification of pertussis cases. Two review authors independently extracted data and assessed the risk of bias in the studies. Differences in trial design precluded a meta-analysis of the efficacy data. We pooled the safety data from individual trials using a random-effects meta-analysis model. We included six efficacy trials with a total of 46,283 participants and 52 safety trials with a total of 136,541 participants. Most of the safety trials did not report the methods for random sequence generation, allocation concealment and blinding, which made it difficult to assess the risk of bias in the studies. The efficacy of multi-component (≥ three) vaccines varied from 84% to 85% in preventing typical whooping cough (characterised by 21 or more consecutive days of paroxysmal cough with confirmation of B. pertussis infection by culture, appropriate serology or contact with a household member who has culture-confirmed pertussis), and from 71% to 78% in preventing mild pertussis disease (characterised by seven or more consecutive days of cough with confirmation of B. pertussis infection by culture or appropriate serology). In contrast, the efficacy of one- and two-component vaccines varied from 59% to 75% against typical whooping cough and from 13% to 54% against mild pertussis disease. Multi-component acellular vaccines are more effective than low-efficacy whole-cell vaccines, but may be less effective than the highest-efficacy whole-cell vaccines. Most systemic and local adverse events were significantly less common with aP vaccines than with wP vaccines for the primary series as well as for the booster dose. Multi-component (≥ three) aP vaccines are effective and show less adverse effects than wP vaccines for the primary series as well as for booster doses.

Interleaving lattice for the Argonne Advanced Photon Source linac

NASA Astrophysics Data System (ADS)

Shin, S.; Sun, Y.; Dooling, J.; Borland, M.; Zholents, A.

2018-06-01

To realize and test advanced accelerator concepts and hardware, a beam line is being reconfigured in the linac extension area (LEA) of the Argonne Advanced Photon Source (APS) linac. A photocathode rf gun installed at the beginning of the APS linac will provide a low emittance electron beam into the LEA beam line. The thermionic rf gun beam for the APS storage ring and the photocathode rf gun beam for the LEA beam line will be accelerated through the linac in an interleaved fashion. In this paper, the design studies for interleaving lattice realization in the APS linac is described with the initial experiment result.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doose, Charles; Jain, Animesh

The APS-U is planned to be a 4th generation hard X-ray light source utilizing a multi-bend achromat (MBA) magnet lattice. The MBA lattice will be installed in the existing APS storage ring enclosure. The stored electron beam will circulate clockwise when viewed from above. The X-ray beamlines will for the most part exit at the same source points as the present APS. This document defines the signs and conventions related to the APS-U MBA magnets. Included in this document are: the local magnet coordinate system, definitions of mechanical and magnetic centers, definitions of multipole field errors, magnetic roll angle, andmore » magnet polarities.« less

VizieR Online Data Catalog: Spatial structure of young stellar clusters. I. (Kuhn+, 2014)

NASA Astrophysics Data System (ADS)

Kuhn, M. A.; Feigelson, E. D.; Getman, K. V.; Baddeley, A. J.; Broos, P. S.; Sills, A.; Bate, M. R.; Povich, M. S.; Luhman, K. L.; Busk, H. A.; Naylor, T.; King, R. R.

2015-07-01

The regions included in this study, listed in Table 1, are nearby sites of high-mass star formation that are included in the MYStIX sample (Feigelson et al. 2013ApJS..209...26F). These regions are covered in the near-IR by the UKIRT Infrared Deep Sky Survey (King et al. 2013, J/ApJS/209/28) or Two-Micron All Sky Survey (Skrutskie et al. 2006, VII/233), in the mid-IR by Spitzer IRAC observations (Kuhn et al. 2013, J/ApJS/209/29), and in the X-ray by the ACIS-I array on the Chandra X-Ray Observatory in the 0.5-8.0keV band (Kuhn et al. 2013, J/ApJS/209/27; Townsley et al. 2014, J/ApJS/213/1). Other sources to produce multiwavelength catalogs are described in section 2. The multiwavelength point-source catalogs are combined with a list of spectroscopic OB stars from the literature, and sources are classified probabilistically to obtain a list of MYStIX Probable Complex Members (MPCMs) (Broos et al. 2013, J/ApJS/209/32). (3 data files).

Propellant grain dynamics in aft attach ring of shuttle solid rocket booster

NASA Technical Reports Server (NTRS)

Verderaime, V.

1979-01-01

An analytical technique for implementing simultaneously the temperature, dynamic strain, real modulus, and frequency properties of solid propellant in an unsymmetrical vibrating ring mode is presented. All dynamic parameters and sources are defined for a free vibrating ring-grain structure with initial displacement and related to a forced vibrating system to determine the change in real modulus. Propellant test data application is discussed. The technique was developed to determine the aft attach ring stiffness of the shuttle booster at lift-off.

TVDG Organization Page

Science.gov Websites

-Booster-AGS Coordinator John Benjamin Accelerator Development, Maintenance and Operation Chuck Carlson Hans Abendroth Ion Source Develoment and Maintenance John Benjamin Dannie Steski Electrical and

X-ray fluorescence surface contaminant analyzer: A feasibility study

NASA Technical Reports Server (NTRS)

Eldridge, Hudson B.

1988-01-01

The bonding of liner material to the inner metal surfaces of solid rocket booster cases is adversely affected by minute amounts of impurities on the metal surface. Suitable non-destructive methods currently used for detecting these surface contaminants do not provide the means of identifying their elemental composition. The feasibility of using isotopic source excited energy dispersive X-ray fluorescence as a possible technique for elemental analysis of such contaminants is investigated. A survey is made of the elemental compositions of both D-6ac steel, a common construction material for the booster cases, and Conoco HD-2 grease, a common surface contamination. Source and detector choices that maximize signal to noise ratio in a Recessed Source Geometry are made. A Monte Carlo simulation is then made of the optimized device incorporating the latest available X-ray constants at the energy of the chosen source to determine the device's response to a D-6ac steel surface contained with Conoco HD-2 grease.

Acellular vaccines for preventing whooping cough in children.

PubMed

Zhang, Linjie; Prietsch, Sílvio O M; Axelsson, Inge; Halperin, Scott A

2014-09-17

Routine use of whole-cell pertussis (wP) vaccines was suspended in some countries in the 1970s and 1980s because of concerns about adverse effects. Following this action, there was a resurgence of whooping cough. Acellular pertussis (aP) vaccines, containing purified or recombinant Bordetella pertussis (B. pertussis) antigens, were developed in the hope that they would be as effective, but less reactogenic than the whole-cell vaccines. This is an update of a Cochrane review first published in 1999, and previously updated in 2012. In this update, we included no new studies. To assess the efficacy and safety of acellular pertussis vaccines in children and to compare them with the whole-cell vaccines. We searched CENTRAL (2013, Issue 12), MEDLINE (1950 to January week 2, 2014), EMBASE (1974 to January 2014), Biosis Previews (2009 to January 2014) and CINAHL (2009 to January 2014). We selected double-blind randomised efficacy and safety trials of aP vaccines in children up to six years old, with active follow-up of participants and laboratory verification of pertussis cases. Two review authors independently extracted data and assessed the risk of bias in the studies. Differences in trial design precluded a meta-analysis of the efficacy data. We pooled the safety data from individual trials using a random-effects meta-analysis model. We included six efficacy trials with a total of 46,283 participants and 52 safety trials with a total of 136,541 participants. Most of the safety trials did not report the methods for random sequence generation, allocation concealment and blinding, which made it difficult to assess the risk of bias in the studies. The efficacy of multi-component (≥ three) vaccines varied from 84% to 85% in preventing typical whooping cough (characterised by 21 or more consecutive days of paroxysmal cough with confirmation of B. pertussis infection by culture, appropriate serology or contact with a household member who has culture-confirmed pertussis), and from 71% to 78% in preventing mild pertussis disease (characterised by seven or more consecutive days of cough with confirmation of B. pertussis infection by culture or appropriate serology). In contrast, the efficacy of one- and two-component vaccines varied from 59% to 78% against typical whooping cough and from 41% to 58% against mild pertussis disease. Multi-component acellular vaccines are more effective than low-efficacy whole-cell vaccines, but may be less effective than the highest-efficacy whole-cell vaccines. Most systemic and local adverse events were significantly less common with aP vaccines than with wP vaccines for the primary series as well as for the booster dose. Multi-component (≥ three) aP vaccines are effective in preventing whooping cough in children. Multi-component aP vaccines have higher efficacy than low-efficacy wP vaccines, but they may be less efficacious than the highest-efficacy wP vaccines. Acellular vaccines have fewer adverse effects than whole-cell vaccines for the primary series as well as for booster doses.

Development and operating experience of a 1.1-m-long superconducting undulator at the Advanced Photon Source

NASA Astrophysics Data System (ADS)

Ivanyushenkov, Y.; Harkay, K.; Borland, M.; Dejus, R.; Dooling, J.; Doose, C.; Emery, L.; Fuerst, J.; Gagliano, J.; Hasse, Q.; Kasa, M.; Kenesei, P.; Sajaev, V.; Schroeder, K.; Sereno, N.; Shastri, S.; Shiroyanagi, Y.; Skiadopoulos, D.; Smith, M.; Sun, X.; Trakhtenberg, E.; Xiao, A.; Zholents, A.; Gluskin, E.

2017-10-01

Development of superconducting undulators continues at the Advanced Photon Source (APS). Two years after successful installation and commissioning of the first relatively short superconducting undulator "SCU0" in Sector 6 of the APS storage ring, the second 1.1-m-long superconducting undulator "SCU1" was installed in Sector 1 of the APS. The device has been in user operation since its commissioning in May 2015. This paper describes the magnetic and cryogenic design of the SCU1 together with the results of stand-alone cold tests. The SCU1's magnetic and cryogenic performance as well as its operating experience in the APS storage ring are also presented.

The Effect of Booster Seat Use on Pediatric Injuries in Motor Vehicle Frontal Crashes.

PubMed

Caskey, Sean; Hammond, Joshua; Peck, Jeffery; Sardelli, Matthew; Atkinson, Theresa

2018-04-20

Motor vehicle crashes are a significant source of pediatric mortality and morbidity. Studies indicate that booster seats significantly improve seat belt fit for children who have not attained a height of 145 cm (4' 9"). This study examined injuries occurring in booster age children up to age 12, as the majority of children do not attain 145 cm until this age. The purpose of the study was to identify differences in injuries due to the type of restraint used, with attention to musculoskeletal injuries. Vehicle and occupant data were obtained from a publically available statistical sample of tow-away crashes. Frontal crashes over an 8-year period were examined. A data set of cases was created involving children ages 5 to 12 years who were unrestrained, restrained using the vehicle's lap and shoulder belt, and restrained using a booster seat with the vehicle's lap and shoulder seat belt. Injury severity, frequency, and patterns of distribution were compared. Unrestrained children experienced moderate to severe injuries 3.8 to 19 times more frequently than children using restraints. There were more injuries to the head and face in unrestrained versus restrained children, but the head and face was the most frequently injured region for all groups. There were no serious cervical spine injuries reported for any group. Lower extremity fractures were not observed in booster seat users but occurred at similar rates in both unrestrained and seat belt restrained children. These fractures occurred in older children who were involved in more severe crashes. Unrestrained children were more likely to experience moderate and severe injuries than restrained children. The data sample suggests that booster use may reduce the risk of extremity fracture, as there were no extremity fractures in children restrained with booster seats. This work provides evidence for the efficacy of booster use for preventing orthopaedic injury in children. This evidence can be used to inform parents and establish recommendations for best practices in transporting children.

High Molecular Weight (HMW) Dissolved Organic Matter (DOM) in Seawater: Chemical Structure, Sources and Cycling

DTIC Science & Technology

1999-06-01

source for APS three species of phytoplankton, Thalassiossira weissflogii, Emiliania huxleyi and Phaeocystis, were cultured in seawater and their HMW...DOM exudates examined by a variety of analytical techniques. Both the T. weissflogii and E. huxleyi exudates contain compounds that resemble APS

Proceedings of the Advanced Photon Source renewal workshop.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibson, J. M.; Mills, D. M.; Kobenhavns Univ.

2008-12-01

Beginning in March 2008, Advanced Photon Source (APS) management engaged users, facility staff, the distinguished members of the APS Scientific Advisory Committee, and other outside experts in crafting a renewal plan for this premier synchrotron x-ray research facility. It is vital that the investment in the APS renewal begin as soon as possible in order to keep this important U.S. facility internationally competitive. The APS renewal plan encompasses innovations in the beamlines and the x-ray source that are needed for major advances in science - advances that promise to further extend the impact of x-ray science on energy research, technologymore » development, materials innovation, economic competitiveness, health, and far-reaching fundamental knowledge. A planning milestone was the APS Renewal Workshop held on October 20-21, 2008. Organized by the APS Renewal Steering Committee, the purpose of the workshop was to provide a forum where leading researchers could present the broad outlines of forward-looking plans for science at the APS in all major disciplines serviced by x-ray techniques. Two days of scientific presentations, discussions, and dialogue involved more than 180 scientists representing 41 institutions. The scientific talks and breakout/discussion sessions provided a forum for Science Team leaders to present the outlines of forward-looking plans for experimentation in all the major scientific disciplines covered by photon science. These proceedings comprise the reports from the Science Teams that were commissioned by the APS Renewal Steering Committee, having been edited by the Science Teams after discussion at the workshop.« less

Reconstruction of sound source signal by analytical passive TR in the environment with airflow

NASA Astrophysics Data System (ADS)

Wei, Long; Li, Min; Yang, Debin; Niu, Feng; Zeng, Wu

2017-03-01

In the acoustic design of air vehicles, the time-domain signals of noise sources on the surface of air vehicles can serve as data support to reveal the noise source generation mechanism, analyze acoustic fatigue, and take measures for noise insulation and reduction. To rapidly reconstruct the time-domain sound source signals in an environment with flow, a method combining the analytical passive time reversal mirror (AP-TR) with a shear flow correction is proposed. In this method, the negative influence of flow on sound wave propagation is suppressed by the shear flow correction, obtaining the corrected acoustic propagation time delay and path. Those corrected time delay and path together with the microphone array signals are then submitted to the AP-TR, reconstructing more accurate sound source signals in the environment with airflow. As an analytical method, AP-TR offers a supplementary way in 3D space to reconstruct the signal of sound source in the environment with airflow instead of the numerical TR. Experiments on the reconstruction of the sound source signals of a pair of loud speakers are conducted in an anechoic wind tunnel with subsonic airflow to validate the effectiveness and priorities of the proposed method. Moreover the comparison by theorem and experiment result between the AP-TR and the time-domain beamforming in reconstructing the sound source signal is also discussed.

USBI Booster Production Company's Hazardous Waste Management Program at the Kennedy Space Center, FL

NASA Technical Reports Server (NTRS)

Venuto, Charles

1987-01-01

In response to the hazardous-waste generating processes associated with the launch of the Space Shuttle, a hazardous waste management plan has been developed. It includes waste recycling, product substitution, waste treatment, and waste minimization at the source. Waste material resulting from the preparation of the nonmotor segments of the solid rocket boosters include waste paints (primer, topcoats), waste solvents (methylene chloride, freon, acetone, toluene), waste inorganic compounds (aluminum anodizing compound, fixer), and others. Ways in which these materials are contended with at the Kennedy Space Center are discussed.

Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome.

PubMed

Tanaka, Yasutaka; Ueno, Yuji; Miyamoto, Nobukazu; Shimada, Yoshiaki; Tanaka, Ryota; Hattori, Nobutaka; Urabe, Takao

2013-01-01

The purpose of the present study was to evaluate the contributions of embolic etiologies, patent foramen ovale (PFO) and atrial septal aneurysm (ASA) to the pathogenesis of ischemic stroke in patients with antiphospholipid syndrome (APS). We performed transesophageal echocardiography (TEE) examination for consecutive stroke patients who had been diagnosed with APS (APS group) to detect potential embolic sources. APS was diagnosed based on the modified Sapporo criteria. The control stroke group comprised age- and sex-matched cryptogenic stroke patients undergoing TEE. We assessed and compared the clinical characteristics and TEE findings between stroke patients with APS and control stroke groups. Among 582 patients, nine patients (nine women; mean age, 50 ± 18 years) were classified into the APS group. In 137 patients undergoing TEE, 41 age-matched female stroke patients were recruited to the control stroke group. Prevalences of PFO and ASA were significantly higher in the APS group than in the control stroke group (89 vs. 41 %, p = 0.027; 67 vs. 20 %, p = 0.015, respectively). Multiple logistic regression analysis showed that PFO (odds ratio (OR), 13.71; 95 % confidence interval (CI), 1.01-185.62; p = 0.049) and ASA (OR, 8.06; 95 % CI, 1.17-55.59; p = 0.034) were independently associated with the APS group. PFO and ASA were strongly associated with the APS group, and could thus represent potential embolic sources in ischemic stroke patients with APS.

Postbooster Antibodies from Humans as Source of Diphtheria Antitoxin

PubMed Central

Avila-Alonso, Ana; González-Rivera, Milagros; Tamayo, Eduardo; Eiros, Jose María; Almansa, Raquel

2016-01-01

Diphtheria antitoxin for therapeutic use is in limited supply. A potential source might be affinity-purified antibodies originally derived from plasma of adults who received a booster dose of a vaccine containing diphtheria toxoid. These antibodies might be useful for treating even severe cases of diphtheria. PMID:27314309

Genomic and Functional Analyses of the 2-Aminophenol Catabolic Pathway and Partial Conversion of Its Substrate into Picolinic Acid in Burkholderia xenovorans LB400

PubMed Central

Agulló, Loreine; González, Myriam; Seeger, Michael

2013-01-01

2-aminophenol (2-AP) is a toxic nitrogen-containing aromatic pollutant. Burkholderia xenovorans LB400 possess an amn gene cluster that encodes the 2-AP catabolic pathway. In this report, the functionality of the 2-aminophenol pathway of B. xenovorans strain LB400 was analyzed. The amnRJBACDFEHG cluster located at chromosome 1 encodes the enzymes for the degradation of 2-aminophenol. The absence of habA and habB genes in LB400 genome correlates with its no growth on nitrobenzene. RT-PCR analyses in strain LB400 showed the co-expression of amnJB, amnBAC, amnACD, amnDFE and amnEHG genes, suggesting that the amn cluster is an operon. RT-qPCR showed that the amnB gene expression was highly induced by 2-AP, whereas a basal constitutive expression was observed in glucose, indicating that these amn genes are regulated. We propose that the predicted MarR-type transcriptional regulator encoded by the amnR gene acts as repressor of the amn gene cluster using a MarR-type regulatory binding sequence. This report showed that LB400 resting cells degrade completely 2-AP. The amn gene cluster from strain LB400 is highly identical to the amn gene cluster from P. knackmussi strain B13, which could not grow on 2-AP. However, we demonstrate that B. xenovorans LB400 is able to grow using 2-AP as sole nitrogen source and glucose as sole carbon source. An amnBA − mutant of strain LB400 was unable to grow with 2-AP as nitrogen source and glucose as carbon source and to degrade 2-AP. This study showed that during LB400 growth on 2-AP this substrate was partially converted into picolinic acid (PA), a well-known antibiotic. The addition of PA at lag or mid-exponential phase inhibited LB400 growth. The MIC of PA for strain LB400 is 2 mM. Overall, these results demonstrate that B. xenovorans strain LB400 posses a functional 2-AP catabolic central pathway, which could lead to the production of picolinic acid. PMID:24124510

Investigation of Gate-Stacked In-Ga-Zn-O TFTs with Ga-Zn-O Source/Drain Electrodes by Atmospheric Pressure Plasma-Enhanced Chemical Vapor Deposition.

PubMed

Wu, Chien-Hung; Chang, Kow-Ming; Chen, Yi-Ming; Huang, Bo-Wen; Zhang, Yu-Xin; Wang, Shui-Jinn; Hsu, Jui-Mei

2018-03-01

Atmospheric pressure plasma-enhanced chemical vapor deposition (AP-PECVD) was employed for the fabrication of indium gallium zinc oxide thin-film transistors (IGZO TFTs) with high transparent gallium zinc oxide (GZO) source/drain electrodes. The influence of post-deposition annealing (PDA) temperature on GZO source/drain and device performance was studied. Device with a 300 °C annealing demonstrated excellent electrical characteristics with on/off current ratio of 2.13 × 108, saturation mobility of 10 cm2/V-s, and low subthreshold swing of 0.2 V/dec. The gate stacked LaAlO3/ZrO2 of AP-IGZO TFTs with highly transparent and conductive AP-GZO source/drain electrode show excellent gate control ability at a low operating voltage.

APS undulator and wiggler sources: Monte-Carlo simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, S.L.; Lai, B.; Viccaro, P.J.

1992-02-01

Standard insertion devices will be provided to each sector by the Advanced Photon Source. It is important to define the radiation characteristics of these general purpose devices. In this document,results of Monte-Carlo simulation are presented. These results, based on the SHADOW program, include the APS Undulator A (UA), Wiggler A (WA), and Wiggler B (WB).

X-ray emission from an Ap star /Phi Herculis/ and a late B star /Pi Ceti/

NASA Technical Reports Server (NTRS)

Cash, W.; Snow, T. P., Jr.; Charles, P.

1979-01-01

Using the HEAO 1 soft X-ray sky survey, a search was conducted for X-ray emission from 18 stars in the spectral range B5-A7. The detection of 0.25 keV X-ray sources consistent with the positions of Pi Ceti, a normal B7 V star, and Phi Herculis, a classic Ap star was reported. The detection of these stars argues for large mass motions in the upper layers of stars in this spectral range, and argues against radiative diffusion as the source of abundance anomalies in Ap stars.

Development and operating experience of a 1.1-m-long superconducting undulator at the Advanced Photon Source

DOE PAGES

Ivanyushenkov, Y.; Harkay, K.; Borland, M.; ...

2017-10-03

Development of superconducting undulators continues at the Advanced Photon Source (APS). Two years after successful installation and commissioning of the first relatively short superconducting undulator “SCU0” in Sector 6 of the APS storage ring, the second 1.1-m long superconducting undulator “SCU1” was installed in Sector 1 of the APS. The device has been in user operation since its commissioning in May 2015. This paper describes the magnetic and cryogenic design of the SCU1 together with the results of stand-alone cold tests. The SCU1’s magnetic and cryogenic performance as well as its operating experience in the APS storage ring are alsomore » presented.« less

Development and operating experience of a 1.1-m-long superconducting undulator at the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ivanyushenkov, Y.; Harkay, K.; Borland, M.

Development of superconducting undulators continues at the Advanced Photon Source (APS). Two years after successful installation and commissioning of the first relatively short superconducting undulator “SCU0” in Sector 6 of the APS storage ring, the second 1.1-m long superconducting undulator “SCU1” was installed in Sector 1 of the APS. The device has been in user operation since its commissioning in May 2015. This paper describes the magnetic and cryogenic design of the SCU1 together with the results of stand-alone cold tests. The SCU1’s magnetic and cryogenic performance as well as its operating experience in the APS storage ring are alsomore » presented.« less

RF Conditioning of the Photo-Cathode RF Gun at the Advanced Photon Source - NWA RF Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, T. L.; DiMonte, N.; Nassiri, A.

A new S-band Photo-cathode (PC) gun was recently installed and RF conditioned at the Advanced Photon Source (APS) Injector Test-stand (ITS) at Argonne National Lab (ANL). The APS PC gun is a LCLS type gun fabricated at SLAC [1]. The PC gun was delivered to the APS in October 2013 and installed in the APS ITS in December 2013. At ANL, we developed a new method of fast detection and mitigation of the guns internal arcs during the RF conditioning process to protect the gun from arc damage and to RF condition more efficiently. Here, we report the results ofmore » RF measurements for the PC gun and an Auto-Restart method for high power RF conditioning.« less

Alkaline phosphatase in nasal secretion of cattle: biochemical and molecular characterisation.

PubMed

Ghazali, M Faizal; Koh-Tan, H H Caline; McLaughlin, Mark; Montague, Paul; Jonsson, Nicholas N; Eckersall, P David

2014-09-05

Nasal secretion (NS) was investigated as a source of information regarding the mucosal and systemic immune status of cattle challenged by respiratory disease. A method for the collection of substantial volumes (~12 ml) of NS from cattle was developed to establish a reference range of analytes that are present in the NS of healthy cattle. Biochemical profiles of NS from a group of 38 healthy Holstein-Friesian cows revealed high alkaline phosphatase (AP) activity of up to 2392 IU/L. The character and source of the high activity of AP in bovine NS was investigated. Histochemical analysis confirmed the localization of the AP enzyme activity to epithelial cells and serous glands of the nasal respiratory mucosa. Analysis of mRNA levels from nasal mucosa by end point RT-PCR and PCR product sequencing confirmed that the AP was locally produced and is identical at the nucleotide level to the non-specific AP splice variant found in bovine liver, bone and kidney. Analysis by isoelectric focussing confirmed that AP was produced locally at a high level in nasal epithelium demonstrating that AP from nasal secretion and nasal mucosa had similar pI bands, though differing from those of the liver, kidney, bone and intestine, suggesting different post-translational modification (PTM) of AP in these tissues. A nasal isozyme of AP has been identified that is present at a high activity in NS, resulting from local production and showing distinctive PTM and may be active in NS as an anti-endotoxin mediator.

The APS SASE FEL : modeling and code comparison.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biedron, S. G.

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

Frontiers of X-ray research at the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dehmer, J.J.

1995-12-31

With providential timing, the Advanced Photon Source (APS) at Argonne National Laboratory has begun to produce x-rays during the centennial year of Wilhelm Rongtgen`s discovery of a {open_quotes}new kind of rays.{close_quotes} When complete, this third-generation, 7-GeV positron storage ring will produce nearly one hundred intense x-ray beams, with a major emphasis on the laser-like (highly collimated, locally coherent) beams from undulator sources. This talk will provide an overview of (1) the important properties of the synchrotron radiation to be produced by the APS, (2) the major classes of experimental approaches that use x-rays, and (3) some speculation on the impactsmore » of the APS on the materials, chemical, biological, and environmental sciences.« less

Diagnostic Systems Plan for the Advanced Light Source Top-OffUpgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barry, Walter; Chin, Mike; Robin, David

2005-05-10

The Advanced Light Source (ALS) will soon be upgraded to enable top-off operations [1], in which electrons are quasi-continuously injected to produce constant stored beam current. The upgrade is structured in two phases. First, we will upgrade our injector from 1.5 GeV to 1.9 GeV to allow full energy injection and will start top-off operations. In the second phase, we will upgrade the Booster Ring (BR) with a bunch cleaning system to allow high bunch purity top-off injection. A diagnostics upgrade will be crucial for success in both phases of the top-off project, and our plan for it is describedmore » in this paper. New booster ring diagnostics will include updated beam position monitor (BPM) electronics, a tune monitoring system, and a new scraper. Two new synchrotron light monitors and a beam stop will be added to the booster-to-storage ring transfer line (BTS), and all the existing beam current monitors along the accelerator chain will be integrated into a single injection efficiency monitoring application. A dedicated bunch purity monitor will be installed in the storage ring (SR). Together, these diagnostic upgrades will enable smooth commissioning of the full energy injector and a quick transition to high quality top-off operation at the ALS.« less

Development and operating experience of a short-period superconducting undulator at the Advanced Photon Source

DOE PAGES

Ivanyushenkov, Y.; Harkay, K.; Abliz, M.; ...

2015-04-01

In this study, a decade-long effort at the Advanced Photon Source (APS) of Argonne National Laboratory (ANL) on development of superconducting undulators culminated in December 2012 with the installation of the first superconducting undulator “SCU0” into Sector 6 of the APS storage ring. The device was commissioned in January 2013 and has been in user operation since. This paper presents the magnetic and cryogenic design of the SCU0 together with the results of stand-alone cold tests. The initial commissioning and characterization of SCU0 as well as its operating experience in the APS storage ring are described.

A Renewal Plan for the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischetti, Robert F.; Fuoss, Paul H.; Gerig, Rodney E.

2010-06-23

With coordination from the APS Renewal Steering Committee (the members of which are the co-authors of this paper), staff and users of the U.S. Department of Energy's Advanced Photon Source (APS) at Argonne National Laboratory are in the process of developing a renewal plan for the facility. The renewal is a coordinated upgrade of the accelerator, beamlines, and associated technical structure that will enable users of the APS to address key scientific challenges in the coming decades. The cost of the renewal is estimated to be from $300M to $400M and to take approximately six years from start to finish.

A novel framework for feature extraction in multi-sensor action potential sorting.

PubMed

Wu, Shun-Chi; Swindlehurst, A Lee; Nenadic, Zoran

2015-09-30

Extracellular recordings of multi-unit neural activity have become indispensable in neuroscience research. The analysis of the recordings begins with the detection of the action potentials (APs), followed by a classification step where each AP is associated with a given neural source. A feature extraction step is required prior to classification in order to reduce the dimensionality of the data and the impact of noise, allowing source clustering algorithms to work more efficiently. In this paper, we propose a novel framework for multi-sensor AP feature extraction based on the so-called Matched Subspace Detector (MSD), which is shown to be a natural generalization of standard single-sensor algorithms. Clustering using both simulated data and real AP recordings taken in the locust antennal lobe demonstrates that the proposed approach yields features that are discriminatory and lead to promising results. Unlike existing methods, the proposed algorithm finds joint spatio-temporal feature vectors that match the dominant subspace observed in the two-dimensional data without needs for a forward propagation model and AP templates. The proposed MSD approach provides more discriminatory features for unsupervised AP sorting applications. Copyright © 2015 Elsevier B.V. All rights reserved.

RF System Requirements for a Medium-Energy Electron-Ion Collider (MEIC) at JLab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rimmer, Robert A; Hannon, Fay E; Guo, Jiquan

2015-09-01

JLab is studying options for a medium energy electron-ion collider that could fit on the JLab site and use CEBAF as a full-energy electron injector. A new ion source, linac and booster would be required, together with collider storage rings for the ions and electrons. In order to achieve the maximum luminosity these will be high-current storage rings with many bunches. We present the high-level RF system requirements for the storage rings, ion booster ring and high-energy ion beam cooling system, and describe the technology options under consideration to meet them. We also present options for staging that might reducemore » the initial capital cost while providing a smooth upgrade path to a higher final energy. The technologies under consideration may also be useful for other proposed storage ring colliders or ultimate light sources.« less

VizieR Online Data Catalog: Blazars with γ-ray counterparts. II. (Massaro+, 2013)

NASA Astrophysics Data System (ADS)

Massaro, F.; D'Abrusco, R.; Paggi, A.; Masetti, N.; Giroletti, M.; Tosti, G.; Smith, H. A.; Funk, S.

2013-06-01

Our primary sample of unidentified γ-ray sources (UGSs) consists of all the sources for which no counterpart was assigned at low energies in the 2FGL or in the 2LAC (Nolan et al. 2012, Cat. J/ApJS/199/31; Ackermann et al. 2011, Cat. J/ApJ/743/171, respectively), for a total of 590 γ-ray objects. We considered and analyzed independently two subsamples of UGSs, distinguishing the 299 Fermi sources without any γ-ray analysis flags from the other 291 objects that have a warning in their γ-ray detection. The complete description of our association procedure together with the estimates of its efficiency and its completeness can be found in D'Abrusco et al. (Paper I, 2013, Cat. J/ApJS/206,12). (9 data files).

Extensive swelling of the limb and systemic symptoms after a fourth dose of acellular pertussis containing vaccines in England in children aged 3-6years.

PubMed

Southern, Jo; Waight, Pauline A; Andrews, Nick; Miller, Elizabeth

2017-01-23

Extensive limb swelling (ESL) after a booster dose of acellular pertussis (aP) containing vaccine can cause concern and has the potential to be confused with cellulitis. In the United Kingdom aP-containing vaccine was introduced for primary immunisation at 2, 3 and 4months of age in 2004, with the first cohorts eligible to receive a fourth dose in 2007 at school entry. We assessed the frequency of ESL (here defined as swelling >100mms diameter) in 973 children receiving a fourth dose of one of four aP vaccines given combined with inactivated polio, tetanus and either low dose diphtheria (TdaP/IPV) or high dose diphtheria (DTaP/IPV) vaccine; 2 of the 3 DTaP/IPV vaccines also contained Haemophilus influenza b conjugate vaccine (Hib). Post-vaccination symptoms and local reactions were recorded in 7-day diaries or by a telephone follow up if no diary was returned. Local swellings >50mm diameter were reported by 2.2% TdaP/IPV recipients compared with 6.6-11.1% of DTaP/IPV recipients; the corresponding proportions for redness >50mms was 7.0% for TdaP/IPV and 13.3-17.7% for DTaP/IPV recipients. Among the latter, the addition of Hib did not affect the frequency or size of local reactions. Pain at the injection site and systemic symptoms did not differ between the four vaccine groups. A history of atopy was not associated with development of local swelling or redness. A total of 13 children (1.3%) experienced an ESL, three after TdaP/IPV. ESLs resolved without systemic upset within a few days and were usually painless; medical advice was only sought for two children. Parents should be informed about the possible occurrence of an ESL with the pre-school aP-containing booster vaccine but can be reassured that it is a benign and transient condition. Copyright © 2016 Elsevier Ltd. All rights reserved.

Two dimensional radial gas flows in atmospheric pressure plasma-enhanced chemical vapor deposition

NASA Astrophysics Data System (ADS)

Kim, Gwihyun; Park, Seran; Shin, Hyunsu; Song, Seungho; Oh, Hoon-Jung; Ko, Dae Hong; Choi, Jung-Il; Baik, Seung Jae

2017-12-01

Atmospheric pressure (AP) operation of plasma-enhanced chemical vapor deposition (PECVD) is one of promising concepts for high quality and low cost processing. Atmospheric plasma discharge requires narrow gap configuration, which causes an inherent feature of AP PECVD. Two dimensional radial gas flows in AP PECVD induces radial variation of mass-transport and that of substrate temperature. The opposite trend of these variations would be the key consideration in the development of uniform deposition process. Another inherent feature of AP PECVD is confined plasma discharge, from which volume power density concept is derived as a key parameter for the control of deposition rate. We investigated deposition rate as a function of volume power density, gas flux, source gas partial pressure, hydrogen partial pressure, plasma source frequency, and substrate temperature; and derived a design guideline of deposition tool and process development in terms of deposition rate and uniformity.

VizieR Online Data Catalog: Water masers in M31. I. Recombination lines (Darling+, 2016)

NASA Astrophysics Data System (ADS)

Darling, J.; Gerard, B.; Amiri, N.; Lawrence, K.

2016-09-01

We constructed a catalog of 506 unresolved 24um sources from the Spitzer 24um map of M31 (Gordon et al. 2006ApJ...638L..87G); see Figure 1. Darling (2011ApJ...732L...2D) observed 206 24um sources in M31 using the Green Bank Telescope (GBT) in 2010 October through December. The 616-523 22.23508GHz ortho-water maser line observations were reported in Darling (2011ApJ...732L...2D), but simultaneous observations of the para-ammonia (NH3) rotational ground-state inversion transitions in the metastable states (J,K)=(1,1) and (2,2) at 23.6945 and 23.72263GHz, respectively, and the hydrogen recombination line H66α at 22.36417GHz were not. We subsequently observed all four of these lines toward an additional 300 24um sources in 2011 October through 2012 January. The resolution of the 24um Spitzer image is 6" (Gordon et al. 2006ApJ...638L..87G), so the unresolved IR sources remained within the 33" GBT beam even during the largest pointing drifts. The 33" beam (FWHM) at 22GHz spans 125pc in M31. (1 data file).

Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort.

PubMed

Setiawan, Veronica Wendy; Pandol, Stephen J; Porcel, Jacqueline; Wei, Pengxiao C; Wilkens, Lynne R; Le Marchand, Loïc; Pike, Malcolm C; Monroe, Kristine R

2017-02-01

Pancreatitis is a source of substantial morbidity and health cost in the United States. Little is known about how diet might contribute to its pathogenesis. To characterize dietary factors that are associated with risk of pancreatitis by disease subtype, we conducted a prospective analysis of 145,886 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the Multiethnic Cohort. In the Multiethnic Cohort (age at baseline, 45-75 y), we identified cases of pancreatitis using hospitalization claim files from 1993 through 2012. Patients were categorized as having gallstone-related acute pancreatitis (AP) (n = 1210), AP not related to gallstones (n = 1222), or recurrent AP or suspected chronic pancreatitis (n = 378). Diet information was obtained from a questionnaire administered when the study began. Associations were estimated by hazard ratios and 95% confidence intervals using Cox proportional hazard models adjusted for confounders. Dietary intakes of saturated fat (P trend = .0011) and cholesterol (P trend = .0008) and their food sources, including red meat (P trend < .0001) and eggs (P trend = .0052), were associated positively with gallstone-related AP. Fiber intake, however, was associated inversely with gallstone-related AP (P trend = .0005) and AP not related to gallstones (P trend = .0035). Vitamin D, mainly from milk, was associated inversely with gallstone-related AP (P trend = .0015), whereas coffee consumption protected against AP not related to gallstones (P trend < .0001). With the exception of red meat, no other dietary factors were associated with recurrent acute or suspected chronic pancreatitis. Associations between dietary factors and pancreatitis were observed mainly for gallstone-related AP. Interestingly, dietary fiber protected against AP related and unrelated to gallstones. Coffee drinking protected against AP not associated with gallstones. Further studies are warranted to confirm our findings. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

Impact of aerosol particle sources on optical properties in urban, regional and remote areas in the north-western Mediterranean

NASA Astrophysics Data System (ADS)

Ealo, Marina; Alastuey, Andrés; Pérez, Noemí; Ripoll, Anna; Querol, Xavier; Pandolfi, Marco

2018-01-01

Further research is needed to reduce the existing uncertainties on the effect that specific aerosol particle sources have on light extinction and consequently on climate. This study presents a new approach that aims to quantify the mass scattering and absorption efficiencies (MSEs and MAEs) of different aerosol sources at urban (Barcelona - BCN), regional (Montseny - MSY) and remote (Montsec - MSA) background sites in the north-western (NW) Mediterranean. An analysis of source apportionment to the measured multi-wavelength light scattering (σsp) and absorption (σap) coefficients was performed by means of a multilinear regression (MLR) model for the periods 2009-2014, 2010-2014 and 2011-2014 at BCN, MSY and MSA respectively. The source contributions to PM10 mass concentration, identified by means of the positive matrix factorization (PMF) model, were used as dependent variables in the MLR model. With this approach we addressed both the effect that aerosol sources have on air quality and their potential effect on light extinction through the determination of their MSEs and MAEs. An advantage of the presented approach is that the calculated MSEs and MAEs take into account the internal mixing of atmospheric particles. Seven aerosol sources were identified at MSA and MSY, and eight sources at BCN. Mineral, aged marine, secondary sulfate, secondary nitrate and V-Ni bearing sources were common at the three sites. Traffic, industrial/metallurgy and road dust resuspension sources were isolated at BCN, whereas mixed industrial/traffic and aged organics sources were identified at MSY and MSA. The highest MSEs were observed for secondary sulfate (4.5 and 10.7 m2 g-1, at MSY and MSA), secondary nitrate (8.8 and 7.8 m2 g-1) and V-Ni bearing source (8 and 3.5 m2 g-1). These sources dominated the scattering throughout the year with marked seasonal trends. The V-Ni bearing source, originating mainly from shipping in the area under study, simultaneously contributed to both σsp and σap, being the second most efficient light-absorbing source in BCN (MAE = 0.9 m2 g-1). The traffic source at BCN and the industrial/traffic at MSY exhibited the highest MAEs (1.7 and 0.9 m2 g-1). These sources were major contributors to σap at BCN and MSY; however at MSA, secondary nitrate exerted the highest influence on σap (MAE = 0.4 m2 g-1). The sources which were predominantly composed of fine and relatively dark particles, such as industrial/traffic, aged organics and V-Ni, were simultaneously characterized by low single scattering albedo (SSA) and a high scattering Ångström exponent (SAE). Conversely, mineral and aged marine showed the lowest SAE and the highest SSA, being scattering the dominant process in the light extinction. The good agreement found between modelled and measured particle optical properties allowed the reconstruction of σsp and σap long-term series over the period 2004-2014 at MSY. Significant decreasing trends were found for the modelled σsp and σap (-4.6 and -4.1 % yr-1).

Design Study of an MBA Lattice for the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Decker, Glenn

2014-11-02

Recent interest in ultra-low-emittance designs for storage-ring-based synchrotron light sources has spurred a focused design effort on a multi-bend achromat (MBA) storage ring replacement for the Advanced Photon Source (APS). The APS is relatively large (1104 m circumference) and, as such, an upgrade to a fourth-generation storage ring holds the potential for a two to three order of magnitude enhancement of X-ray brightness due to the approximate inverse cubic scaling of emittance with the number of dipole bend magnets.

Non-Destructive Characterization of Engineering Materials Using High-Energy X-rays at the Advanced Photon Source

DOE PAGES

Park, Jun-Sang; Okasinski, John; Chatterjee, Kamalika; ...

2017-05-30

High energy X-rays can penetrate large components and samples made from engineering alloys. Brilliant synchrotron sources like the Advanced Photon Source (APS) combined with unique experimental setups are increasingly allowing scientists and engineers to non-destructively characterize the state of materials across a range of length scales. In this article, some of the new developments at the APS, namely the high energy diffraction microscopy technique for grain-by-grain maps and aperture-based techniques for aggregate maps, are described.

Non-Destructive Characterization of Engineering Materials Using High-Energy X-rays at the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Jun-Sang; Okasinski, John; Chatterjee, Kamalika

High energy X-rays can penetrate large components and samples made from engineering alloys. Brilliant synchrotron sources like the Advanced Photon Source (APS) combined with unique experimental setups are increasingly allowing scientists and engineers to non-destructively characterize the state of materials across a range of length scales. In this article, some of the new developments at the APS, namely the high energy diffraction microscopy technique for grain-by-grain maps and aperture-based techniques for aggregate maps, are described.

Evaluation of agro-industrial wastes, their state, and mixing ratio for maximum polygalacturonase and biomass production in submerged fermentation.

PubMed

Göğüş, Nihan; Evcan, Ezgi; Tarı, Canan; Cavalitto, Sebastián F

2015-01-01

The potential of important agro-industrial wastes, apple pomace (AP) and orange peel (OP) as C sources, was investigated in the maximization of polygalacturonase (PG), an industrially significant enzyme, using an industrially important microorganism Aspergillus sojae. Factors such as various hydrolysis forms of the C sources (hydrolysed-AP, non-hydrolysed-AP, hydrolysed-AP + OP, non-hydrolysed-AP + OP) and N sources (ammonium sulphate and urea), and incubation time (4, 6, and 8 days) were screened. It was observed that maximum PG activity was achieved at a combination of non-hydrolysed-AP + OP and ammonium sulphate with eight days of incubation. For the pre-optimization study, ammonium sulphate concentration and the mixing ratios of AP + OP at different total C concentrations (9, 15, 21 g l(-1)) were evaluated. The optimum conditions for the maximum PG production (144.96 U ml(-1)) was found as 21 g l(-1) total carbohydrate concentration totally coming from OP at 15 g l(-1) ammonium sulphate concentration. On the other hand, 3:1 mixing ratio of OP + AP at 11.50 g l(-1) ammonium sulphate concentration also resulted in a considerable PG activity (115.73 U ml(-1)). These results demonstrated that AP can be evaluated as an additional C source to OP for PG production, which in turn both can be alternative solutions for the elimination of the waste accumulation in the food industry with economical returns.

Large-eddy simulations of a solid-rocket booster jet

NASA Astrophysics Data System (ADS)

Paoli, Roberto; Poubeau, Adele; Cariolle, Daniel

2014-11-01

Emissions from solid-rocket boosters are responsible for a severe decrease in ozone concentration in the rocket plume during the first hours after a launch. The main source of ozone depletion is due to hydrogen chloride that is converted into chlorine in the high temperature regions of the jet (afterburning). The objective of this study is to evaluate the active chlorine concentration in the plume of a solid-rocket booster using large-eddy simulations. The gas is injected through the entire nozzle of the booster and a local time-stepping method based on coupling multi-instances of a fluid solver is used to extend the computational domain up to 600 nozzle exit diameters. The methodology is validated for a non-reactive case by analyzing the flow characteristics of supersonic co-flowing under expanded jets. Then, the chemistry of chlorine is studied offline using a complex chemistry solver and the LES data extracted from the mean trajectories of sample fluid particles. Finally, the online chemistry is analyzed by means of the multispecies version of the LES solver using a reduced chemistry scheme. The LES are able to capture the mixing of the exhaust with ambient air and the species concentrations, which is also useful to initialize atmospheric simulations on larger domains.

Comparison of expression and enzymatic properties of Aspergillus oryzae lysine aminopeptidases ApsA and ApsB.

PubMed

Marui, Junichiro; Matsushita-Morita, Mayumi; Tada, Sawaki; Hattori, Ryota; Suzuki, Satoshi; Amano, Hitoshi; Ishida, Hiroki; Yamagata, Youhei; Takeuchi, Michio; Kusumoto, Ken-Ichi

2012-08-01

The apsA and apsB genes encoding family M1 aminopeptidases were identified in the industrial fungus Aspergillus oryzae. The apsB was transcriptionally up-regulated up to 2.5-fold in response to the deprivation of nitrogen or carbon sources in growth media, while up-regulation of apsA was less significant. The encoded proteins were bacterially expressed and purified to characterize their enzymatic properties. ApsA and ApsB were optimally active at pH 7.0 and 35 °C and stable at pH ranges of 6-10 and 4-10, respectively, up to 40 °C. The enzymes were inhibited by bestatin and EDTA, as has been reported for family M1 aminopeptidases that characteristically contain a zinc-binding catalytic motif. Both enzymes preferentially liberated N-terminal lysine, which is an essential amino acid and an important additive to animal feed. Enzymes that efficiently release N-terminal lysine from peptides could be useful for food and forage industries. Examination of the reactivity toward peptide substrate of varying length revealed that ApsB exhibited broader substrate specificity than ApsA although the reactivity of ApsB decreased as the length of peptide substrate decreased.

A comparison of self-report and direct observation of booster seat use in Latino families.

PubMed

Quistberg, D Alex; Lozano, Paula; Mack, Christopher D; Schwartz, Rachel; Ebel, Beth E

2010-08-01

To develop a reliable self-report tool for measuring child booster seat use among Latino families. Cross-sectional and observational survey of a convenience sample. Five retail stores in King County, Washington. 50 parents of children 4-8 years old that self-identified as Latino or Hispanic. Parent-reported measures of how often the child uses a booster seat, if the child used a booster seat on the last trip, how often the child complains about using a booster seat, how often the child asks to not use a booster seat, and how often other families they know use a booster seat. Observed booster seat use by child. 26 children (52%) were observed using a booster seat. Parent-reported booster seat use was a poor predictor of observed booster seat use. Although 34 parents reported that their child 'always' uses a booster seat, 8 (24%) of these children were not using a booster seat. A logistic model to predict booster seat use had a sensitivity of 81% and a specificity of 71%, and misclassified 24% of the participants' observed use. Reliance on parent-reported booster seat use significantly overstated observed booster seat use in the study. Among this study population, accurate determination of booster seat use required direct observation.

Developing an undue influence screening tool for Adult Protective Services.

PubMed

Quinn, Mary Joy; Nerenberg, Lisa; Navarro, Adria E; Wilber, Kathleen H

2017-03-01

The study purpose was to develop and pilot an undue influence screening tool for California's Adult Protective Services (APS) personnel based on the definition of undue influence enacted into California law January 1, 2014. Methods included four focus groups with APS providers (n = 33), piloting the preliminary tool by APS personnel (n = 15), and interviews with four elder abuse experts and two APS administrators. Social service literature-including existing undue influence models-was reviewed, as were existing screening and assessment tools. Using the information from these various sources, the California Undue Influence Screening Tool (CUIST) was developed. It can be applied to APS cases and potentially adapted for use by other professionals and for use in other states. Implementation of the tool into APS practice, policy, procedures, and training of personnel will depend on the initiative of APS management. Future work will need to address the reliability and validity of CUIST.

Influence of the external and internal parameters on the characteristics of generator PV

NASA Astrophysics Data System (ADS)

Zouli, Mounir; Ghoudelbourk, Sihem; Ouari, Ahmed; Dib, Djallel

2017-02-01

The growing demand for electric power and inevitable future depletion of conventional sources require major research on the alternative sources, like renewable energies. Among which, solar energy is the most largely used because of its many applications. And as Algeria comprises an exceptional solar layer thanks to its large surfaces, therefore it represents an important source of photovoltaic energy. The objective of this work is to be ensured that the energy produced by the photovoltaic plant supplies the electrical distribution network. The configuration of this system comprises a photovoltaic generator, connected to a chopper booster. For an optimal operation of the system, one must connect in cascades partial generators each one connected to a chopper booster adapted by an order MPPT by the method of Disturbance and Observation (P&O) to ensure the operation of their maximum powers whatever the climatic conditions, and also allows to raise the output voltage of these photovoltaic generators. The adaptation between the photovoltaic generator and the load was carried out with the help of converter DC/DC.

ONLINE MINIMIZATION OF VERTICAL BEAM SIZES AT APS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Yipeng

In this paper, online minimization of vertical beam sizes along the APS (Advanced Photon Source) storage ring is presented. A genetic algorithm (GA) was developed and employed for the online optimization in the APS storage ring. A total of 59 families of skew quadrupole magnets were employed as knobs to adjust the coupling and the vertical dispersion in the APS storage ring. Starting from initially zero current skew quadrupoles, small vertical beam sizes along the APS storage ring were achieved in a short optimization time of one hour. The optimization results from this method are briefly compared with the onemore » from LOCO (Linear Optics from Closed Orbits) response matrix correction.« less

Sensitive screening of abused drugs in dried blood samples using ultra-high-performance liquid chromatography-ion booster-quadrupole time-of-flight mass spectrometry.

PubMed

Chepyala, Divyabharathi; Tsai, I-Lin; Liao, Hsiao-Wei; Chen, Guan-Yuan; Chao, Hsi-Chun; Kuo, Ching-Hua

2017-03-31

An increased rate of drug abuse is a major social problem worldwide. The dried blood spot (DBS) sampling technique offers many advantages over using urine or whole blood sampling techniques. This study developed a simple and efficient ultra-high-performance liquid chromatography-ion booster-quadrupole time-of-flight mass spectrometry (UHPLC-IB-QTOF-MS) method for the analysis of abused drugs and their metabolites using DBS. Fifty-seven compounds covering the most commonly abused drugs, including amphetamines, opioids, cocaine, benzodiazepines, barbiturates, and many other new and emerging abused drugs, were selected as the target analytes of this study. An 80% acetonitrile solvent with a 5-min extraction by Geno grinder was used for sample extraction. A Poroshell column was used to provide efficient separation, and under optimal conditions, the analytical times were 15 and 5min in positive and negative ionization modes, respectively. Ionization parameters of both electrospray ionization source and ion booster (IB) source containing an extra heated zone were optimized to achieve the best ionization efficiency of the investigated abused drugs. In spite of their structural diversity, most of the abused drugs showed an enhanced mass response with the high temperature ionization from an extra heated zone of IB source. Compared to electrospray ionization, the ion booster (IB) greatly improved the detection sensitivity for 86% of the analytes by 1.5-14-fold and allowed the developed method to detect trace amounts of compounds on the DBS cards. The validation results showed that the coefficients of variation of intra-day and inter-day precision in terms of the signal intensity were lower than 19.65%. The extraction recovery of all analytes was between 67.21 and 115.14%. The limits of detection of all analytes were between 0.2 and 35.7ngmL -1 . The stability study indicated that 7% of compounds showed poor stability (below 50%) on the DBS cards after 6 months of storage at room temperature and -80°C. The reported method provides a new direction for abused drug screening using DBS. Copyright © 2017 Elsevier B.V. All rights reserved.

Beam Loss Simulation and Collimator System Configurations for the Advanced Photon Source Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao, A.; Borland, M.

The proposed multi-bend achromat lattice for the Advanced Photon Source upgrade (APS-U) has a design emittance of less than 70 pm. The Touschek loss rate is high: compared with the current APS ring, which has an average beam lifetime ~ 10 h, the simulated beam lifetime for APS-U is only ~2 h when operated in the high flux mode (I=200 mA in 48 bunches). An additional consequence of the short lifetime is that injection must be more frequent, which provides another potential source of particle loss. In order to provide information for the radiation shielding system evaluation and to avoidmore » particle loss in sensitive locations around the ring (for example, insertion device straight sections), simulations of the detailed beam loss distribution have been performed. Several possible collimation configurations have been simulated and compared.« less

Characterization and subcellular localization of aminopeptidases in senescing barley leaves

NASA Technical Reports Server (NTRS)

Thayer, S. S.; Choe, H. T.; Rausser, S.; Huffaker, R. C.

1988-01-01

Four aminopeptidases (APs) were separated using native polyacrylamide gel electrophoresis of cell-free extracts and the stromal fractions of isolated chloroplasts prepared from primary barley (Hordeum vulgare L., var Numar) leaves. Activities were identified using a series of aminoacyl-beta-naphthylamide derivatives as substrates. AP1, 2, and 3 were found in the stromal fraction of isolated chloroplasts with respective molecular masses of 66.7, 56.5, and 54.6 kilodaltons. AP4 was found only in the cytoplasmic fraction. No AP activity was found in vacuoles of these leaves. It was found that 50% of the L-Leu-beta-naphthylamide and 25% of the L-Arg-beta-naphthylamide activities were localized in the chloroplasts. Several AP activities were associated with the membranes of the thylakoid fraction of isolated chloroplasts. AP1, 2, and 4 reacted against a broad range of substrates, whereas AP3 hydrolyzed only L-Arg-beta-naphthylamide. Only AP2 hydrolyzed L-Val-beta-naphthylamide. Since AP2 and AP3 were the only ones reacting against Val-beta-naphthylamide and Arg-beta-naphthylamide, respectively, several protease inhibitors were tested against these substrates using a stromal fraction from isolated chloroplasts as the source of the two APs. Both APs were sensitive to both metallo and sulfhydryl type inhibitors. Although AP activity decreased as leaves senesced, no new APs appeared on gels during senescence and none disappeared.

A comparative study on the analytical utility of atmospheric and low-pressure MALDI sources for the mass spectrometric characterization of peptides.

PubMed

Moskovets, Eugene; Misharin, Alexander; Laiko, Viktor; Doroshenko, Vladimir

2016-07-15

A comparative MS study was conducted on the analytical performance of two matrix-assisted laser desorption/ionization (MALDI) sources that operated at either low pressure (∼1Torr) or at atmospheric pressure. In both cases, the MALDI sources were attached to a linear ion trap mass spectrometer equipped with a two-stage ion funnel. The obtained results indicate that the limits of detection, in the analysis of identical peptide samples, were much lower with the source that was operated slightly below the 1-Torr pressure. In the low-pressure (LP) MALDI source, ion signals were observed at a laser fluence that was considerably lower than the one determining the appearance of ion signals in the atmospheric pressure (AP) MALDI source. When the near-threshold laser fluences were used to record MALDI MS spectra at 1-Torr and 750-Torr pressures, the level of chemical noise at the 1-Torr pressure was much lower compared to that at AP. The dependency of the analyte ion signals on the accelerating field which dragged the ions from the MALDI plate to the MS analyzer are presented for the LP and AP MALDI sources. The study indicates that the laser fluence, background gas pressure, and field accelerating the ions away from a MALDI plate were the main parameters which determined the ion yield, signal-to-noise (S/N) ratios, the fragmentation of the analyte ions, and adduct formation in the LP and AP MALDI MS methods. The presented results can be helpful for a deeper insight into the mechanisms responsible for the ion formation in MALDI. Copyright © 2016 Elsevier Inc. All rights reserved.

Antioxidant genes of the emerald ash borer (Agrilus planipennis): gene characterization and expression profiles.

PubMed

Rajarapu, Swapna Priya; Mamidala, Praveen; Herms, Daniel A; Bonello, Pierluigi; Mittapalli, Omprakash

2011-06-01

Phytophagous insects frequently encounter reactive oxygen species (ROS) from exogenous and endogenous sources. To overcome the effect of ROS, insects have evolved a suite of antioxidant defense genes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX) and glutathione peroxidase (GPX). The emerald ash borer (Agrilus planipennis Fairmaire), an exotic invasive insect pest from Asia has killed millions of ash trees and continues to invade North America at a rapid pace. From an on-going expressed sequence tag (EST) project of A. planipennis larval tissues, we identified ESTs coding for a Cu-Zn SOD (ApSOD1), a CAT (ApCAT1) and a GPX (ApGPX1). A multiple sequence alignment of the derived A. planipennis sequences revealed high homology with other insect sequences at the amino acid level. Phylogenetic analysis of ApSOD1 grouped it with Cu-Zn SODs of other insect taxa. Quantitative real time PCR (qRT-PCR) analysis in different larval tissues (midgut, fat body, Malpighian tubule and cuticle) revealed high mRNA levels of ApCAT1 in the midgut. Interestingly, high mRNA levels for both ApSOD1 and ApGPX1 were observed in the Malpighian tubules. Assay of mRNA levels in developmental stages (larva, prepupa and adults) by qRT-PCR indicated high transcript levels of ApCAT1 and ApGPX1 in larval and prepupal stages with a decline in adults. On the other hand, the transcript levels of ApSOD1 were observed to be constitutive in all the developmental stages assayed. Results obtained reflect a plausible role of these A. planipennis antioxidant genes in quenching ROS from both diet (ash allelochemicals) as well as endogenous sources. These studies further help in understanding the adaptation/invasiveness of A. planipennis. Copyright © 2011 Elsevier Ltd. All rights reserved.

Comparison of Amplitudes and Frequencies of Explosive vs. Hammer Seismic Sources for a 1-km Seismic Line in West Texas

NASA Astrophysics Data System (ADS)

Kaip, G.; Harder, S. H.; Karplus, M. S.; Vennemann, A.

2016-12-01

In May 2016, the National Seismic Source Facility (NSSF) located at the University of Texas at El Paso (UTEP) Department of Geological Sciences collected seismic data at the Indio Ranch located 30 km southwest of Van Horn, Texas. Both hammer on an aluminum plate and explosive sources were used. The project objective was to image subsurface structures at the ranch, owned by UTEP. Selecting the appropriate seismic source is important to reach project objectives. We compare seismic sources between explosions and hammer on plate, focusing on amplitude and frequency. The seismic line was 1 km long, trending WSW to ENE, with 200 4.5 Hz geophones at 5m spacing and shot locations at 10m spacing. Clay slurry was used in shot holes to increase shot coupling around booster. Trojan Spartan cast boosters (150g) were used in explosive sources in each shot hole (1 hole per station). The end of line shots had 5 shot holes instead of 1 (750g total). The hammer source utilized a 5.5 kg hammer and an aluminum plate. Five hammer blows were stacked at each location to improve signal-to-noise ratio. Explosive sources yield higher amplitude, but lower frequency content. The explosions exhibit a higher signal-to-noise ratio, allowing us to recognize seismic energy deeper and farther from the source. Hammer sources yield higher frequencies, allowing better resolution at shallower depths but have a lower signal-to-noise ratio and lower amplitudes, even with source stacking. We analyze the details of the shot spectra from the different types of sources. A combination of source types can improve data resolution and amplitude, thereby improving imaging potential. However, cost, logistics, and complexities also have a large influence on source selection.

Cabling design of booster and storage ring construction progress of TPS

NASA Astrophysics Data System (ADS)

Wong, Y.-S.; Liu, K.-B.; Liu, C.-Y.; Wang, b.-S.

2017-06-01

The 2012 Taiwan Photon Source (TPS) cable construction project started after 10 months to complete the cable laying and installation of power supply. The circumference of the booster ring (BR) is 496.8 m, whereas that of the storage ring (SR) is 518.4 m. Beam current is set to 500 mA at 3.3 GeV. The paper on grounding systems discusses the design of the ground wire (< 0.2 Ω) with low impedance, power supply of the accelerator and cabling tray. The flow and size of the ground current are carefully evaluated to avoid grounded current from flowing everywhere, which causes interference problems. In the design of the TPS, special shielding will be established to isolate the effects of electromagnetic interference on the magnet and ground current. Booster ring dipoles are connected by a series of 54-magnet bending dipole; the cable size of its stranded wire measures 250 mm2, with a total length of 5000 m. Booster ring and storage ring quadrupoles have 150 magnets; the cable size of their stranded wire is 250 mm2, with a total length of 17000 m. Storage ring dipole consists of 48 magnets; the cable size of its stranded wire is 325 mm2, with a total length of 6000 m. This study discusses the power supply cabling design of the storage ring and booster ring construction progress of TPS. The sections of this paper are divided into discussions of the construction of the control and instrument area, cabling layout of booster ring and storage ring, as well as the installation and commission machine. This study also discusses the use of a high-impedance meter to determine the effect of cabling insulation and TPS power supply machine on energy transfer to ensure the use of safe and correct magnet.

VizieR Online Data Catalog: IR photometry of AGNs in Swift/BAT 70 month cat. (Ichikawa+, 2017)

NASA Astrophysics Data System (ADS)

Ichikawa, K.; Ricci, C.; Ueda, Y.; Matsuoka, K.; Toba, Y.; Kawamuro, T.; Trakhtenbrot, B.; Koss, M. J.

2017-08-01

Our initial sample contains the 834 AGNs reported in the 70 month Swift/BAT catalog (Baumgartner+ 2013, J/ApJS/207/19), 105 of which are blazars. Of the remaining 729 sources, 697 sources have secure redshift information as presented in Ricci et al. (2016, ApJ, submitted). Next, we removed galaxy pairs or interacting galaxies not resolved in the BAT survey. Further, the 606 sources located at higher galactic latitudes with |b|>10° were selected to reduce the contamination in the crowded region through IR catalog matching. (1 data file).

The periodic very young source EC 53 reached its maximum brightness

NASA Astrophysics Data System (ADS)

Giannini, T.; Antoniucci, S.; Lorenzetti, D.; Harutyunyan, A.; Licchelli, D.; Munari, U.

2018-06-01

In the framework of our EXor monitoring program dubbed EXORCISM (EXOR OptiCal and Infrared Systematic Monitoring - Antoniucci et al. 2013 PPVI, Lorenzetti et al. 2007 ApJ 665, 1182; Lorenzetti et al. 2009 ApJ 693, 1056), we observed the object EC53 recently signaled by Johnston et al. (ATel #11614) as a strongly embedded source showing a sub-mm luminosity burst, They also provide H- and K-band observations detecting this brightness increase also in the near-IR, in the scattered light by the nebula surrounding a compact source, invisible at those wavelengths.

Leaf-architectured 3D Hierarchical Artificial Photosynthetic System of Perovskite Titanates Towards CO2 Photoreduction Into Hydrocarbon Fuels

PubMed Central

Zhou, Han; Guo, Jianjun; Li, Peng; Fan, Tongxiang; Zhang, Di; Ye, Jinhua

2013-01-01

The development of an “artificial photosynthetic system” (APS) having both the analogous important structural elements and reaction features of photosynthesis to achieve solar-driven water splitting and CO2 reduction is highly challenging. Here, we demonstrate a design strategy for a promising 3D APS architecture as an efficient mass flow/light harvesting network relying on the morphological replacement of a concept prototype-leaf's 3D architecture into perovskite titanates for CO2 photoreduction into hydrocarbon fuels (CO and CH4). The process uses artificial sunlight as the energy source, water as an electron donor and CO2 as the carbon source, mimicking what real leaves do. To our knowledge this is the first example utilizing biological systems as “architecture-directing agents” for APS towards CO2 photoreduction, which hints at a more general principle for APS architectures with a great variety of optimized biological geometries. This research would have great significance for the potential realization of global carbon neutral cycle. PMID:23588925

Role of amplified spontaneous emission in optical free-space communication links with optical amplification: impact on isolation and data transmission and utilization for pointing, acquisition, and

NASA Astrophysics Data System (ADS)

Winzer, Peter J.; Kalmar, Andras; Leeb, Walter R.

1999-04-01

We investigate the role of amplified spontaneous emission (ASE) produced by an optical booster amplifier at the transmitter of free-space optical communication links. In a communication terminal with a single telescope for both transmission and reception, this ASE power has to be taken into account in connection with transmit-to-receive channel isolation, especially since it partly occupies the same state of polarization and the same frequency band as the receive signal. We show that the booster ASE intercepted by the receiver can represent a non-negligible source of background radiation: In a typical optical intersatellite link scenario, the ASE power spectral density generated by the booster amplifier at the transmitter and coupled to the receiver will be on the order of 10-20 W/Hz, which equals the background radiation of the sun. Exploiting these findings for pointing, acquisition, and tracking (PAT) purposes, we describe a patent-pending PAT system doing without beacon lasers and without the need for diverting a part of the data signal for PAT. Utilizing the transmit booster ASE over a bandwidth of e.g. 20 nm at the receiver, a total power of about -46 dBm is available for PAT purposes without extra power consumption at the transmitter and without the need for beacon lAser alignment.

Alkaline Phosphatase, an Unconventional Immune Protein.

PubMed

Rader, Bethany A

2017-01-01

Recent years have seen an increase in the number of studies focusing on alkaline phosphatases (APs), revealing an expanding complexity of function of these enzymes. Of the four human AP (hAP) proteins, most is known about tissue non-specific AP (TNAP) and intestinal AP (IAP). This review highlights current understanding of TNAP and IAP in relation to human health and disease. TNAP plays a role in multiple processes, including bone mineralization, vitamin B6 metabolism, and neurogenesis, is the genetic cause of hypophosphatasia, influences inflammation through regulation of purinergic signaling, and has been implicated in Alzheimer's disease. IAP regulates fatty acid absorption and has been implicated in the regulation of diet-induced obesity and metabolic syndrome. IAP and TNAP can dephosphorylate bacterial-derived lipopolysaccharide, and IAP has been identified as a potential regulator of the composition of the intestinal microbiome, an evolutionarily conserved function. Endogenous and recombinant bovine APs and recombinant hAPs are currently being explored for their potential as pharmacological agents to treat AP-associated diseases and mitigate multiple sources of inflammation. Continued research on these versatile proteins will undoubtedly provide insight into human pathophysiology, biochemistry, and the human holobiont.

Use of microalgae to recycle nutrients in aqueous phase derived from hydrothermal liquefaction process.

PubMed

Leng, Lijian; Li, Jun; Wen, Zhiyou; Zhou, Wenguang

2018-05-01

Hydrothermal liquefaction (HTL) of microalgae biomass generates an aqueous phase (AP) byproduct with limited energy value. Recycling the AP solution as a source of nutrients for microalgae cultivation provides an opportunity for a cost-effective production of HTL based biofuel and algal biomass feedstock for HTL, allowing a closed-loop biofuel production in microalgae HTL biofuel system. This paper aims to provide a comprehensive overview of characteristics of AP and its nutrients recycling for algae production. Inhibitory effects resulted from the toxic compounds in AP and alleviation strategies are discussed. Copyright © 2018 Elsevier Ltd. All rights reserved.

VizieR Online Data Catalog: FIR bright sources of M83 (Foyle+, 2013)

NASA Astrophysics Data System (ADS)

Foyle, K.; Natale, G.; Wilson, C. D.; Popescu, C. C.; Baes, M.; Bendo, G. J.; Boquien, M.; Boselli, A.; Cooray, A.; Cormier, D.; de Looze, I.; Fischera, J.; Karczewski, O. L.; Lebouteiller, V.; Madden, S.; Pereira-Santaella, M.; Smith, M. W. L.; Spinoglio, L.; Tuffs, R. J.

2015-07-01

We use FIR images from the Herschel Space Observatory to trace cold dust emission. We use 70 and 160um maps taken with the PACS and 250 and 350um maps taken with the SPIRE. We trace the warm dust and PAH emission using MIR maps taken from the Spitzer Local Volume Legacy Survey (Dale et al., 2009ApJ...703..517D, Cat. J/ApJ/703/517). We use continuum-subtracted Hα maps from the Survey for Ionization in Neutral Gas Galaxies (SINGG; Meurer et al., 2006ApJS..165..307M, Cat. J/ApJS/165/307). (4 data files).

Primary and booster vaccination in Latin American children with a DTPw-HBV/Hib combination: a randomized controlled trial.

PubMed

Espinoza, Felix; Tregnaghi, Miguel; Gentile, Angela; Abarca, Katia; Casellas, Javier; Collard, Alix; Lefevre, Inge; Jacquet, Jeanne-Marie

2010-10-15

Diphtheria-tetanus-whole-cell pertussis (DTPw)-based combination vaccines are an attractive option to rapidly achieve high coverage and protection against other important pathogens, such as hepatitis B virus (HBV) and Haemophilus influenzae type B (Hib). To ensure adequate antigen supply, GlaxoSmithKline Biologicals has introduced a new DTPw antigen source and developed a new DTPw-HBV/Hib combination vaccine containing a reduced amount of Hib polyribosylribitol phosphate (PRP). This study was undertaken to compare the immunogenicity and reactogenicity of this new DTPw-HBV/Hib vaccine with a licensed DTPw-HBV/Hib vaccine (Tritanrix™-HBV/Hib). This was a randomized, partially-blind, multicenter study in three countries in Latin America (Argentina, Chile and Nicaragua). Healthy children received either the new DTPw-HBV/Hib vaccine (1 of 3 lots; n = 439; double-blind) or Tritanrix™-HBV/Hib (n = 146; single-blind) co-administered with oral poliovirus vaccine (OPV) at 2, 4 and 6 months, with a booster dose at 18-24 months. One month after the end of the 3-dose primary vaccination course, the new DTPw-HBV/Hib vaccine was non-inferior to Tritanrix™-HBV/Hib in terms of seroprotection/vaccine response rates for all component antigens; ≥97.3% and ≥93.9% of subjects in the two groups, respectively, had seroprotective levels of antibodies against diphtheria, tetanus, hepatitis B and Hib and a vaccine response to the pertussis component. Persistence of antibodies against all vaccine antigens was comparable between groups, with marked increases in all antibody concentrations after booster administration in both groups. Both vaccines were generally well-tolerated as primary and booster doses. Results confirm the suitability of this new DTPw-HBV/Hib vaccine comprising antigens from a new source and a reduced PRP content for inclusion into routine childhood vaccination programs. http://www.clinicaltrials.gov NCT00332566.

Implications of culture positivity in acute pancreatitis: does the source matter?

PubMed

Rao, Chalapathi; Bhasin, Deepak Kumar; Rana, Surinder Singh; Gupta, Rajesh; Gautam, Vikas; Singh, Kartar

2013-05-01

Sepsis is an important complication and cause of morbidity and mortality in acute pancreatitis (AP). The source of sepsis may be infected pancreatic and peripancreatic collections and/or necrosis or extrapancreatic including infections in the bloodstream or respiratory and urinary tracts. We studied the implications of the source of sepsis on various outcome parameters in AP like persistent organ failure (POF), length of hospital (LOH) stay, and mortality. A retrospective analysis of culture reports of AP patients was done, and the outcome parameters were recorded. Three hundred fifty-seven patients (229 M; age: 40.3 ± 14.04 years) of AP who had detailed culture reports were included. Eighty-four (23.5%) patients had pancreatic (or peripancreatic) source (group 1), 52 (14.6%) patients had other (extrapancreatic) sources (group 2), 20 (5.6%) patients were noted to have positive cultures from sources, which were both pancreatic and extrapancreatic (combined) sources (group 3), while 201 patients had sterile cultures. POF was seen in 147 (48%) patients (group 1: 67.8%; group 2: 65%; group 3: 90%; group 4: 34% [P < 0.001]). The mean LOH stay was 22.1 ± 20.26 days (group 1: 30.2 ± 20.64 days; group 2: 26.4 ± 26.82 days; group 3: 47.3 ± 32.60 days; group 4: 15.2 ± 11.34 days [P < 0.001]). Seventy (19.7%) patients succumbed to their illness (group 1 [22.9%]; group 2 [36.5%]; group 3 [40%]; group 4 [12%] [P < 0.001]). POF and LOH stay were more common in patients with combined pancreatic and extrapancreatic sources of sepsis. Mortality was significantly higher in patients with sepsis (groups 1, 2, 3) compared with sterile groups. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

IMPEDANCE MEASUREMENT OF VACUUM CHAMBER COMPONENTS FOR THE ADVANCE PHOTON SOURCE (APS) UPGRADE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sangroula, M.; Lindberg, R.; Lill, R.

2017-06-16

The proposed Advance Photon Source Upgrade (APS-U) employs a multi-bend achromat (MBA) lattice to increase the photon brightness by two to three orders of magnitude. One of the main design challenges of the upgrade is to minimize rf heating and collective instabilities associated with the impedance of small-aperture vacuum components. As part of this effort, my research focuses on impedance measurement and simulation of various MBA vacuum components. Here, we present the summary of the impedance contributions for the APS-U and describe our planned impedance measurement technique, including some measurement results for the non-evaporative getter (NEG)-coated copper chamber and simulationmore » results for other critical components using a novel Goubau line (G-line) set up.« less

Impedance measurement of vacuum chamber components for the Advance Photon Source(APS) Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sangroula, M.; Lindberg, R.; Lill, R.

2017-01-01

The proposed Advance Photon Source Upgrade (APS-U) employs a multi-bend achromat (MBA) lattice to increase the photon brightness by two to three orders of magnitude. One of the main design challenges of the upgrade is to minimize rf heating and collective instabilities associated with the impedance of small-aperture vacuum components. As part of this effort, my research focuses on impedance measurement and simulation of various MBA vacuum components. Here, we present the summary of the impedance contributions for the APS-U and describe our planned impedance measurement technique, including some measurement results for the non-evaporative getter (NEG)-coated copper chamber and simulationmore » results for other critical components using a novel Goubau line (G-line) set up.« less

Liquid Rocket Booster (LRB) for the Space Transportation System (STS) systems study. Appendix B: Liquid rocket booster acoustic and thermal environments

NASA Technical Reports Server (NTRS)

1989-01-01

The ascent thermal environment and propulsion acoustic sources for the Martin-Marietta Corporation designed Liquid Rocket Boosters (LRB) to be used with the Space Shuttle Orbiter and External Tank are described. Two designs were proposed: one using a pump-fed propulsion system and the other using a pressure-fed propulsion system. Both designs use LOX/RP-1 propellants, but differences in performance of the two propulsion systems produce significant differences in the proposed stage geometries, exhaust plumes, and resulting environments. The general characteristics of the two designs which are significant for environmental predictions are described. The methods of analysis and predictions for environments in acoustics, aerodynamic heating, and base heating (from exhaust plume effects) are also described. The acoustic section will compare the proposed exhaust plumes with the current SRB from the standpoint of acoustics and ignition overpressure. The sections on thermal environments will provide details of the LRB heating rates and indications of possible changes in the Orbiter and ET environments as a result of the change from SRBs to LRBs.

Design study of the CEPC booster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Chuang

2014-12-10

Design study of the CEPC booster is reported. The booster provides 120 GeV beams for the collider with topup injection frequency of 0.1 Hz. To save cost, energy of the linac injector for the booster is chosen as 6GeV, corresponding to the magnetic field of 30 Gs. In this paper, lattice of the booster is described; the low injection energy issues are studied; beam transfer from linac to booster and from booster to collider are discussed.

OSSE Observations of Blazars

DTIC Science & Technology

1995-01-01

factor of 10, with a factor of 4 increase in 4 hours reported on one occasion from EXOSAT observations ( Morini et al. 1986). The source also exhibited...Konigl, A. 1989, ApJ, 340, 162 Morini , M., Chiappetti, L., Maccagni, D., Maraschi, L., Molteni, D., Tanzi, E. G., Treves, A., & Wolter, A. 1986, ApJ

VizieR Online Data Catalog: Taurus ultra-wide pairs (Joncour+, 2017)

NASA Astrophysics Data System (ADS)

Joncour, I.; Duchene, G.; Moraux, E.

2017-05-01

Although a recent catalog of Taurus members has been released including newly detected mid-infrared Wide-field Infrared Survey Explorer (WISE) sources (Esplin et al., 2014, Cat. J/ApJ/784/126), we adopted the catalog containing 352 Taurus members that offers a full census of members down to 0.02 Mȯ(Luhman et al., 2010, Cat. J/ApJS/186/111; Rebull et al., 2010, Cat. J/ApJS/186/259), which we supplemented with stellar multiplicity data. (3 data files).

A comprehensive library-based, automated screening procedure for 46 synthetic cannabinoids in serum employing liquid chromatography-quadrupole ion trap mass spectrometry with high-temperature electrospray ionization.

PubMed

Huppertz, Laura M; Kneisel, Stefan; Auwärter, Volker; Kempf, Jürgen

2014-02-01

Considering the vast variety of synthetic cannabinoids and herbal mixtures - commonly known as 'Spice' or 'K2' - on the market and the resulting increase of severe intoxications related to their consumption, there is a need in clinical and forensic toxicology for comprehensive up-to-date screening methods. The focus of this project aimed at developing and implementing an automated screening procedure for the detection of synthetic cannabinoids in serum using a liquid chromatography-ion trap-MS (LC-MS(n)) system and a spectra library-based approach, currently including 46 synthetic cannabinoids and 8 isotope labelled analogues. In the process of method development, a high-temperature ESI source (IonBooster(TM), Bruker Daltonik) and its effects on the ionization efficiency of the investigated synthetic cannabinoids were evaluated and compared to a conventional ESI source. Despite their structural diversity, all investigated synthetic cannabinoids benefitted from high-temperature ionization by showing remarkably higher MS intensities compared to conventional ESI. The employed search algorithm matches retention time, MS and MS(2)/MS(3) spectra. With the utilization of the ionBooster source, limits for the automated detection comparable to cut-off values of routine MRM methods were achieved for the majority of analytes. Even compounds not identified when using a conventional ESI source were detected using the ionBooster-source. LODs in serum range from 0.1 ng/ml to 0.5 ng/ml. The use of parent compounds as analytical targets offers the possibility of instantly adding new emerging compounds to the library and immediately applying the updated method to serum samples, allowing the rapid adaptation of the screening method to ongoing forensic or clinical requirements. The presented approach can also be applied to other specimens, such as oral fluid or hair, and herbal mixtures and was successfully applied to authentic serum samples. Quantitative MRM results of samples with analyte concentrations above the determined LOD were confirmed as positive findings by the presented method. Copyright © 2014 John Wiley & Sons, Ltd.

Update on Risk Reduction Activities for a Liquid Advanced Booster for NASA's Space Launch System

NASA Technical Reports Server (NTRS)

Crocker, Andy; Greene, William D.

2017-01-01

Goals of NASA's Advanced Booster Engineering Demonstration and/or Risk Reduction (ABEDRR) are to: (1) Reduce risks leading to an affordable Advanced Booster that meets the evolved capabilities of SLS. (2) Enable competition by mitigating targeted Advanced Booster risks to enhance SLS affordability. SLS Block 1 vehicle is being designed to carry 70 mT to LEO: (1) Uses two five-segment solid rocket boosters (SRBs) similar to the boosters that helped power the space shuttle to orbit. Evolved 130 mT payload class rocket requires an advanced booster with more thrust than any existing U.S. liquid-or solid-fueled boosters

47 CFR 27.9 - Operation of certificated signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false Operation of certificated signal boosters. 27.9... boosters. Individuals and non-individuals may operate certificated Consumer Signal Boosters on frequencies... operate a signal booster. [78 FR 21564, Apr. 11, 2013] ...

47 CFR 27.9 - Operation of certificated signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false Operation of certificated signal boosters. 27.9... boosters. Individuals and non-individuals may operate certificated Consumer Signal Boosters on frequencies... operate a signal booster. [78 FR 21564, Apr. 11, 2013] ...

Alternative School Revenue Sources: There Are Many Fish in the Sea.

ERIC Educational Resources Information Center

Pijanowski, John C.; Monk, David H.

1996-01-01

To ease fiscal strain, many school districts employ alternative fund-raising initiatives. They are forming local foundations or booster clubs, soliciting businesses or volunteers for in-kind donations, selling and leasing services and facilities, generating investment income, collecting user fees, cooperating with social service providers,…

MULTI-OBJECTIVE ONLINE OPTIMIZATION OF BEAM LIFETIME AT APS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Yipeng

In this paper, online optimization of beam lifetime at the APS (Advanced Photon Source) storage ring is presented. A general genetic algorithm (GA) is developed and employed for some online optimizations in the APS storage ring. Sextupole magnets in 40 sectors of the APS storage ring are employed as variables for the online nonlinear beam dynamics optimization. The algorithm employs several optimization objectives and is designed to run with topup mode or beam current decay mode. Up to 50\\% improvement of beam lifetime is demonstrated, without affecting the transverse beam sizes and other relevant parameters. In some cases, the top-upmore » injection efficiency is also improved.« less

Feasibility demonstration of booster cross-over system for 3 1/2 inch SRB/MLP frangible nut system

NASA Technical Reports Server (NTRS)

1983-01-01

Recent testing of the SRB/MLP Frangible Nut System (SOS Part Number 114850-9/Boosters P/N 114848-3) at NASA indicated a need to reduce the function time between boosters (2) within a single frangible nut. These boosters are initiated separately by electrical impulse(s). Coupling the output of each detonator with an explosive cross-over would reduce the function time between boosters (independent of electrical impulse) while providing additional redundancy to the system. The objectives of this program were to: provide an explosive cross-over between boosters, reduce function time between boosters to less than one (1) millisecond within a given nut, reduce cost of boosters, be compatible with the existing frangible nut system, and meet requirements of USBI Spec's (nut 10SPC-0030, booster 10SPC-0031).

Crab Cavity and Cryomodule Prototype Development for the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, H; Ciovati, G; Clemens, W A

2011-03-01

We review the single-cell, superconducting crab cavity designs for the short-pulse x-ray (SPX) project at the Advanced Photon Source (APS). The 'on-cell' waveguide scheme is expected to have a more margin for the impedance budget of the APS storage ring, as well as offering a more compact design compared with the original design consisting of a low order mode damping waveguide on the beam pipe. We will report recent fabrication progress, cavity test performance on original and alternate prototypes, and concept designs and analysis for various cryomodule components.

Compatibility of booster seats and vehicles in the U.S. market.

PubMed

Bing, Julie A; Agnew, Amanda M; Bolte, John H

2018-05-19

The objective of this study was to analyze booster and rear vehicle seat dimensions to identify the most frequent compatibility problems. Measurements were collected from 40 high-back and backless boosters and 95 left rear and center rear row seating positions in 50 modern vehicles. Dimensions were compared for 3,800 booster/vehicle seat combinations. For validation and estimation of tolerance and correction factors, 72 booster installations were physically completed and compared with measurement-based compatibility predictions. Dimensions were also compared to the International Organization for Standardization (ISO) volumetric envelopes of forward-facing child restraints and boosters. Seat belt buckles in outboard positions accommodated the width of boosters better than center positions (success rates of 85.4 and 34.7%, respectively). Adequate head restraint clearance occurred in 71.9 to 77.2% of combinations, depending on the booster's head support setting. Booster recline angles aligned properly with vehicle seat cushion angles in 71.5% of combinations. In cases of poor angle alignment, booster angles were more obtuse than the vehicle seat angles 97.7% of the time. Head restraint interference exacerbated angle alignment issues. Data indicate success rates above 90% for boosters being fully supported by the length of the seat cushion and for adequate height clearance with the vehicle roofline. Comparison to ISO envelopes indicates that most boosters on the U.S. market are taller and angled more obtusely than ISO target envelopes. This study quantifies some of the common interferences between boosters and vehicles that may complicate booster usage. Data are useful for design and to prioritize specific problem areas.

47 CFR 74.1203 - Interference.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FM Broadcast Booster Stations § 74.1203 Interference. (a) An authorized FM translator or booster..., TV booster, FM translator or FM booster station; or (3) The direct reception by the public of the off... FM booster stations. Interference will be considered to occur whenever reception of a regularly used...

47 CFR 74.1203 - Interference.

Code of Federal Regulations, 2013 CFR

2013-10-01

... FM Broadcast Booster Stations § 74.1203 Interference. (a) An authorized FM translator or booster..., TV booster, FM translator or FM booster station; or (3) The direct reception by the public of the off... FM booster stations. Interference will be considered to occur whenever reception of a regularly used...

47 CFR 74.1203 - Interference.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FM Broadcast Booster Stations § 74.1203 Interference. (a) An authorized FM translator or booster..., TV booster, FM translator or FM booster station; or (3) The direct reception by the public of the off... FM booster stations. Interference will be considered to occur whenever reception of a regularly used...

47 CFR 74.1203 - Interference.

Code of Federal Regulations, 2012 CFR

2012-10-01

... FM Broadcast Booster Stations § 74.1203 Interference. (a) An authorized FM translator or booster..., TV booster, FM translator or FM booster station; or (3) The direct reception by the public of the off... FM booster stations. Interference will be considered to occur whenever reception of a regularly used...

VizieR Online Data Catalog: KGS EoR0 Catalogue (Carroll+, 2016)

NASA Astrophysics Data System (ADS)

Carroll, P. A.; Line, J.; Morales, M. F.; Barry, N.; Beardsley, A. P.; Hazelton, B. J.; Jacobs, D. C.; Pober, J. C.; Sullivan, I. S.; Webster, R. L.; Bernardi, G.; Bowman, J. D.; Briggs, F.; Cappallo, R. J.; Corey, B. E.; de Oliveira-Costa, A.; Dillon, J. S.; Emrich, D.; Ewall-Wice, A.; Feng, L.; Gaensler, B. M.; Goeke, R.; Greenhill, L. J.; Hewitt, J. N.; Hurley-Walker, N.; Johnston-Hollitt, M.; Kaplan, D. L.; Kasper, J. C.; Kim, Hs.; Kratzenberg, E.; Lenc, E.; Loeb, A.; Lonsdale, C. J.; Lynch, M. J.; McKinley, B.; McWhirter, S. R.; Mitchell, D. A.; Morgan, E.; Neben, A. R.; Oberoi, D.; Offringa, A. R.; Ord, S. M.; Paul, S.; Pindor, B.; Prabu, T.; Procopio, P.; Riding, J.; Rogers, A. E. E.; Roshi, A.; Udaya Shankar, N.; Sethi, S. K.; Srivani, K. S.; Subrahmanyan, R.; Tegmark, M.; Thyagarajan, N.; Tingay, S. J.; Trott, C. M.; Waterson, M.; Wayth, R. B.; Whitney, A. R.; Williams, A.; Williams, C. L.; Wu, C.; Wyithe, J. S. B.

2018-01-01

The MWA EoR0 field is centred at RA=0h and Dec=-27°, and was chosen because it has no bright complex sources in the primary field of view. The FWHM of the antenna beam is approximately 20°, but sources in the edges of the beam and first few side lobes are clearly visible and should be subtracted (Thyagarajan et al., 2015ApJ...804...14T, 2015ApJ...807L..28T; Pober et al., 2016ApJ...819....8P). For this catalogue we concentrate on identifying sources in the primary beam but go out to the 5 per cent power point (nearly first beam null, ~1400deg2). The data for this catalogue include 752min snapshot observations (112s consecutive integrations with 8s gaps) from the night of 2013 August 23. The observations were made at 182MHz with 31MHz bandwidth and cover 2.5h in total. This process for source finding, measurement, and classification has been termed KATALOGSS (KDD Astrometry, Trueness, and Apparent Luminosity of Galaxies in Snapshot Surveys; hereafter abbreviated to KGS). (1 data file).

Identifying risk factors for progression to critical care admission and death among individuals with acute pancreatitis: a record linkage analysis of Scottish healthcare databases

PubMed Central

Mole, Damian J; Gungabissoon, Usha; Johnston, Philip; Cochrane, Lynda; Hopkins, Leanne; Wyper, Grant M A; Skouras, Christos; Dibben, Chris; Sullivan, Frank; Morris, Andrew; Ward, Hester J T; Lawton, Andrew M; Donnan, Peter T

2016-01-01

Objectives Acute pancreatitis (AP) can initiate systemic complications that require support in critical care (CC). Our objective was to use the unified national health record to define the epidemiology of AP in Scotland, with a specific focus on deterministic and prognostic factors for CC admission in AP. Setting Health boards in Scotland (n=4). Participants We included all individuals in a retrospective observational cohort with at least one episode of AP (ICD10 code K85) occurring in Scotland from 1 April 2009 to 31 March 2012. 3340 individuals were coded as AP. Methods Data from 16 sources, spanning general practice, community prescribing, Accident and Emergency attendances, hospital in-patient, CC and mortality registries, were linked by a unique patient identifier in a national safe haven. Logistic regression and gamma models were used to define independent predictive factors for severe AP (sAP) requiring CC admission or leading to death. Results 2053 individuals (61.5% (95% CI 59.8% to 63.2%)) met the definition for true AP (tAP). 368 patients (17.9% of tAP (95% CI 16.2% to 19.6%)) were admitted to CC. Predictors of sAP were pre-existing angina or hypertension, hypocalcaemia and age 30–39 years, if type 2 diabetes mellitus was present. The risk of sAP was lower in patients with multiple previous episodes of AP. In-hospital mortality in tAP was 5.0% (95% CI 4.1% to 5.9%) overall and 21.7% (95% CI 19.9% to 23.5%) in those with tAP necessitating CC admission. Conclusions National record-linkage analysis of routinely collected data constitutes a powerful resource to model CC admission and prognosticate death during AP. Mortality in patients with AP who require CC admission remains high. PMID:27311912

Observations of Distant Clusters

NASA Technical Reports Server (NTRS)

Donahue, Megan

2004-01-01

The is the proceedings and papers supported by the LTSA grant: Homer, D. J.\\& Donahue, M. 2003, in "The Emergence of Cosmic Structure": 13'h Astrophysics Conference Proceedings, Vol. 666,3 1 1-3 14, (AIP). Baumgartner, W. H., Loewenstein, M., Horner, D. J., Mushotzky, R. F. 2003, HEAD- AAS, 35.3503. Homer, D. J. , Donahue, M., Voit G. M. 2003, HEAD-AAS, 35.1309. Nowak, M. A., Smith, B., Donahue, M., Stocke, J. 2003, HEAD-AAS, 35.1316. Scott, D., Borys, C., Chapman, S. C., Donahue, M., Fahlman, G. G., Halpem, M. Newbury, P. 2002, AAS, 128.01. Jones, L. R. et al. 2002, A new era in cosmology, ASP Conference Proceedings, Vol. 283, p. 223 Donahue, M., Daly, R. A., Homer, D. J. 2003, ApJ, 584, 643, Constraints on the Cluster Environments and Hotspot magnetic field strengths for radio sources 3280 and 3254. Donahue, M., et al. 2003, ApJ, 598, 190. The mass, baryonic fraction, and x-ray temperature of the luminous, high-redshift cluster of galaxies MS045 1.6-0305 Perlman, E. S. et al. 2002, ApJS, 140, 256. Smith, B. J., Nowak, M., Donahue, M., Stocke, J. 2003, AJ, 126, 1763. Chandra Observations of the Interacting NGC44 10 Group of Galaxies. Postman, M., Lauer, T. R., Oegerle, W., Donahue, M. 2002, ApJ, 579, 93. The KPNO/deep-range cluster survey I. The catalog and space density of intermediate-redshift clusters. Molnar, S. M., Hughes, J. P., Donahue, M., Joy, M. 2002, ApJ, 573, L91, Chandra Observations of Unresolved X-Ray Sources around Two Clusters of Galaxies. Donahue, M., Mack, J., 2002 NewAR, 46, 155, HST NIcmos and WFPC2 observations of molecular hydrogen and dust around cooling flows. Koekemoer, A. M. et al. 2002 NewAR, 46, 149, Interactions between the A2597 central radio source and dense gas host galaxy. Donahue, M. et al. 2002 ApJ, 569,689, Distant cluster hunting II.

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.733 - UHF translator signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false UHF translator signal boosters. 74.733 Section... Translator, and TV Booster Stations § 74.733 UHF translator signal boosters. (a) The licensee of a UHF television broadcast translator station may be authorized to operate one or more signal boosters for the...

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.733 - UHF translator signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false UHF translator signal boosters. 74.733 Section... Translator, and TV Booster Stations § 74.733 UHF translator signal boosters. (a) The licensee of a UHF television broadcast translator station may be authorized to operate one or more signal boosters for the...

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.733 - UHF translator signal boosters.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false UHF translator signal boosters. 74.733 Section... Translator, and TV Booster Stations § 74.733 UHF translator signal boosters. (a) The licensee of a UHF television broadcast translator station may be authorized to operate one or more signal boosters for the...

Space shuttle with common fuel tank for liquid rocket booster and main engines (supertanker space shuttle)

NASA Technical Reports Server (NTRS)

Thorpe, Douglas G.

1991-01-01

An operation and schedule enhancement is shown that replaces the four-body cluster (Space Shuttle Orbiter (SSO), external tank, and two solid rocket boosters) with a simpler two-body cluster (SSO and liquid rocket booster/external tank). At staging velocity, the booster unit (liquid-fueled booster engines and vehicle support structure) is jettisoned while the remaining SSO and supertank continues on to orbit. The simpler two-bodied cluster reduces the processing and stack time until SSO mate from 57 days (for the solid rocket booster) to 20 days (for the liquid rocket booster). The areas in which liquid booster systems are superior to solid rocket boosters are discussed. Alternative and future generation vehicles are reviewed to reveal greater performance and operations enhancements with more modifications to the current methods of propulsion design philosophy, e.g., combined cycle engines, and concentric propellant tanks.

Initiation Capacity of a Specially Shaped Booster Pellet and Numerical Simulation of Its Initiation Process

NASA Astrophysics Data System (ADS)

Hu, Li-Shuang; Hu, Shuang-Qi; Cao, Xiong; Zhang, Jian-Ren

2014-01-01

The insensitive main charge explosive is creating new requirements for the booster pellet of detonation trains. The traditional cylindrical booster pellet has insufficient energy output to reliably initiate the insensitive main charge explosive. In this research, a concave spherical booster pellet was designed. The initiation capacity of the concave spherical booster pellet was studied using varied composition and axial steel dent methods. The initiation process of the concave spherical booster pellet was also simulated by ANSYS/LS-DYNA. The results showed that using a concave spherical booster allows a 42% reduction in the amount of explosive needed to match the initiation capacity of a conventional cylindrical booster of the same dimensions. With the other parameters kept constant, the initiation capacity of the concave spherical booster pellet increases with decreased cone angle and concave radius. The numerical simulation results are in good agreement with the experimental data.

Tailored interventions for screening mammography among a sample of initially non-adherent women: when is a booster dose important?

PubMed

Skinner, Celette Sugg; Kobrin, Sarah C; Monahan, Patrick O; Daggy, Joanne; Menon, Usha; Todora, Helen Smith; Champion, Victoria L

2007-01-01

To assess added value of a booster dose of a tailored mammography intervention. Participants, non-adherent at baseline, were randomly assigned to usual care or one of three tailored interventions. Intervention group members (n=657) were further randomly assigned to receive/not receive a booster intervention dose. Electronic record mammography data were collected following initial intervention and at 6 and 15 months post-booster. Booster had no effect among women not screened after first intervention dose (n=337). Among women screened after initial dose (n=320), booster predicted re-screening at 6 but not 15 months. A boosterxrace interaction showed a booster effect at 6 months for African Americans (OR=4.66, p=.0005) but not Caucasians (OR=0.74, p=.44). Findings suggest if a first-dose intervention does not facilitate screening, neither will a booster dose. However, among women for whom a first dose is effective, boosters can facilitate timely repeat adherence, especially among African Americans. At 6 months booster recipients were less likely to be off-schedule but, by 15 months, the groups were similar. Boosters may effect when, but not whether, women continue screening.

APS SCIENCE 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fenner, Richard B.

The Advanced Photon Source (APS) occupies an 80-acre site on the Argonne national laboratory campus, about 25 miles from downtown chicago, illinois. it shares the site with the center for nanoscale materials and the Advanced Protein characterization facility. for directions to Argonne, see http://www.anl.gov/directions-and-visitor-information. The APS, a national synchrotron radiation research facility operated by Argonne for the u.S. department of energy (doe) office of Science, provides this nation’s brightest high-energy x-ray beams for science. research by APS users extends from the center of the earth to outer space, from new information on combustion engines and microcircuits to new drugs andmore » nanotechnologies whose scale is measured in billionths of a meter. The APS helps researchers illuminate answers to the challenges of our high-tech world, from developing new forms of energy, to sustaining our nation’s technological and economic competitiveness, to pushing back against the ravages of disease. research at the APS promises to have far-reaching« less

X-ray optics simulation and beamline design for the APS upgrade

NASA Astrophysics Data System (ADS)

Shi, Xianbo; Reininger, Ruben; Harder, Ross; Haeffner, Dean

2017-08-01

The upgrade of the Advanced Photon Source (APS) to a Multi-Bend Achromat (MBA) will increase the brightness of the APS by between two and three orders of magnitude. The APS upgrade (APS-U) project includes a list of feature beamlines that will take full advantage of the new machine. Many of the existing beamlines will be also upgraded to profit from this significant machine enhancement. Optics simulations are essential in the design and optimization of these new and existing beamlines. In this contribution, the simulation tools used and developed at APS, ranging from analytical to numerical methods, are summarized. Three general optical layouts are compared in terms of their coherence control and focusing capabilities. The concept of zoom optics, where two sets of focusing elements (e.g., CRLs and KB mirrors) are used to provide variable beam sizes at a fixed focal plane, is optimized analytically. The effects of figure errors on the vertical spot size and on the local coherence along the vertical direction of the optimized design are investigated.

Benchmarking of Touschek Beam Lifetime Calculations for the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao, A.; Yang, B.

2017-06-25

Particle loss from Touschek scattering is one of the most significant issues faced by present and future synchrotron light source storage rings. For example, the predicted, Touschek-dominated beam lifetime for the Advanced Photon Source (APS) Upgrade lattice in 48-bunch, 200-mA timing mode is only ~ 2 h. In order to understand the reliability of the predicted lifetime, a series of measurements with various beam parameters was performed on the present APS storage ring. This paper first describes the entire process of beam lifetime measurement, then compares measured lifetime with the calculated one by applying the measured beam parameters. The resultsmore » show very good agreement.« less

The 7BM beamline at the APS: a facility for time-resolved fluid dynamics measurements

PubMed Central

Kastengren, Alan; Powell, Christopher F.; Arms, Dohn; Dufresne, Eric M.; Gibson, Harold; Wang, Jin

2012-01-01

In recent years, X-ray radiography has been used to probe the internal structure of dense sprays with microsecond time resolution and a spatial resolution of 15 µm even in high-pressure environments. Recently, the 7BM beamline at the Advanced Photon Source (APS) has been commissioned to focus on the needs of X-ray spray radiography measurements. The spatial resolution and X-ray intensity at this beamline represent a significant improvement over previous time-resolved X-ray radiography measurements at the APS. PMID:22713903

Preclinical medical students’ understandings of academic and medical professionalism: visual analysis of mind maps

PubMed Central

Rees, Charlotte E

2017-01-01

Introduction Several studies have begun to explore medical students’ understandings of professionalism generally and medical professionalism specifically. Despite espoused relationships between academic (AP) and medical professionalism (MP), previous research has not yet investigated students’ conceptualisations of AP and MP and the relationships between the two. Objectives The current study, based on innovative visual analysis of mind maps, therefore aims to contribute to the developing literature on how professionalism is understood. Methods We performed a multilayered analysis of 98 mind maps from 262 first-year medical students, including analysing textual and graphical elements of AP, MP and the relationships between AP and MP. Results The most common textual attributes of AP were learning, lifestyle and personality, while attributes of MP were knowledge, ethics and patient-doctor relations. Images of books, academic caps and teachers were used most often to represent AP, while images of the stethoscope, doctor and red cross were used to symbolise MP. While AP-MP relations were sometimes indicated through co-occurring text, visual connections and higher-order visual metaphors, many students struggled to articulate the relationships between AP and MP. Conclusions While the mind maps’ textual attributes shared similarities with those found in previous research, suggesting the universality of some professionalism attributes, our study provides new insights into students’ conceptualisations of AP, MP and AP-MP relationships. We encourage medical educators to help students develop their understandings of AP, MP and AP-MP relationships, plus consider the feasibility and value of mind maps as a source of visual data for medical education research. PMID:28821520

VizieR Online Data Catalog: CANDELS multiwavelength catalog (Galametz+, 2013)

NASA Astrophysics Data System (ADS)

Galametz, A.; Grazian, A.; Fontana, A.; Ferguson, H. C.; Ashby, M. L. N.; Barro, G.; Castellano, M.; Dahlen, T.; Donley, J. L.; Faber, S. M.; Grogin, N.; Guo, Y.; Huang, K.-H.; Kocevski, D. D.; Koekemoer, A. M.; Lee, K.-S.; McGrath, E. J.; Peth, M.; Willner, S. P.; Almaini, O.; Cooper, M.; Cooray, A.; Conselice, C. J.; Dickinson, M.; Dunlop, J. S.; Fazio, G. G.; Foucaud, S.; Gardner, J. P.; Giavalisco, M.; Hathi, N. P.; Hartley, W. G.; Koo, D. C.; Lai, K.; de Mello, D. F.; McLure, R. J.; Lucas, R. A.; Paris, D.; Pentericci, L.; Santini, P.; Simpson, C.; Sommariva, V.; Targett, T.; Weiner, B. J.; Wuyts, S.; CANDELS Team

2013-06-01

The present multiwavelength catalog is based on public data in the CANDELS UDS field (J2000 position: 02:17:37.5-05:12:00) located within the original UDS field. It includes: * CANDELS HST/ACS (F606W, F814W) and HST/WFC3 (F125W, F160W); Grogin et al. 2011ApJS..197...35G, Koekemoer et al. 2011ApJS..197...36K. * CFHT U-band (UKIDSS; Almaini et al. in prep.), * SUBARU B, V, Rc, i', z' (SXDS; Furusawa et al. 2008, Cat. J/ApJS/176/1) * VLT/HAWK-I Y and Ks bands (HUGS; Fontana et al. in prep.) * UKIRT/WFCam J, H, K (UKIDSS DR8; Almaini et al. in prep.) * Spitzer/IRAC SEDS 3.6 and 4.5um (SEDS; Ashby et al. 2013ApJ...769...80A) * Spitzer/IRAC SpUDS 5.8, 8.0um (PI: J. Dunlop). The catalog is F160W-selected and contains 35932 sources over an area of 201.7 square arcmin and includes radio and X-ray detected sources and spectroscopic redshifts available for 210 sources. The full official CANDELS UDS catalog (which contains some extra columns including additional SExtractor parameters derived from the F160W image) can be found on the CANDELS website at: http://candels.ucolick.org/data_access/UDS.html (1 data file).

APS Science 2009.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibson, J. M; Mills, D. M.; Gerig, R.

It is my pleasure to introduce the 2009 annual report of the Advanced Photon Source. This was a very good year for us. We operated with high reliability and availability, despite growing problems with obsolete systems, and our users produced a record output of publications. The number of user experiments increased by 14% from 2008 to more than 3600. We congratulate the recipients of the 2009 Nobel Prize in Chemistry-Venkatraman Ramakrishnan (Cambridge Institute for Medical Research), Thomas Steitz (Yale University), and Ada Yonath (Weizmann Institute) - who did a substantial amount of this work at APS beamlines. Thanks to themore » efforts of our users and staff, and the ongoing counsel of the APS Scientific Advisory Committee, we made major progress in advancing our planning for the upgrade of the APS (APS-U), producing a proposal that was positively reviewed. We hope to get formal approval in 2010 to begin the upgrade. With advocacy from our users and the support of our sponsor, the Office of Basic Energy Sciences in the Department of Energy (DOE) Office of Science, our operating budgets have grown to the level needed to more adequately staff our beamlines. We were also extremely fortunate to have received $7.9 M in American Recovery and Reinvestment Act ('stimulus') funding to acquire new detectors and improve several of our beamlines. The success of the new Linac Coherent Light Source at Stanford, the world's first x-ray free-electron laser, made us particularly proud since the undulators were designed and built by the APS. Among other highlights, we note that more than one-quarter of the 46 Energy Frontier Research Centers, funded competitively across the U.S. in 2009 by the DOE, included the Advanced Photon Source in their proposed work, which shows that synchrotron radiation, and the APS in particular, are central to energy research. While APS research covers everything from fundamental to applied science (reflected by the highlights in this report), the challenge of sustainable energy provides an opportunity for expanded involvement with industrial research. We were privileged to recruit several outstanding new leaders at the APS. Linda Young, from Argonne's Chemical Sciences Division, became the new Director of the X-ray Science Division (XSD). Chris Jacobsen (from Stony Brook University) has been added to Linda's team as an XSD Associate Division Director, joining George Srajer. Alexander (Sasha) Zholents (formerly of Berkeley Lab) became Director of the Accelerator Systems Division. Sasha is the inventor of the short-pulse x-ray scheme that we plan to implement in the APS-U to obtain very high average brightness, broadband, 1-ps x-ray pulses. Walter Lowe (formerly of Howard University) has taken a new position as senior advisor for outreach and development of the user community. Walter's role is to increase the diversity of the user community (with diversity read broadly to include users, institutions, and technical disciplines that are underrepresented at APS). Walter is also leading an effort to increase access for industrial users. I am confident that we have in place a great team to help our users and the APS take fullest advantage of the APS-U opportunity. In planning with users for the proposed APS-U, we focused on the need to study 'real materials under real conditions in real time' on spatial and temporal scales unavailable today. Only by studying materials as they are made-or as they perform-in difficult environments can we solve the grand challenge of higher-performance, sustainable materials for energy and health. The proposed APS-U will improve the brightness of penetrating x-rays produced by the APS over 100 times, and support our efforts in developing state-of-the-art instruments to address these challenges.« less

Space shuttle phase B. Volume 2: Technical summary, addendum A

NASA Technical Reports Server (NTRS)

1971-01-01

A study was conducted to analyze the characteristics and performance data for the booster vehicles to be used with the space shuttle operations. It was determined that the single pressure-fed booster offered the lowest program cost per flight of the pressure-fed booster arrangements studied. The fly back booster required the highest peak annual funding and highest program cost. It was recommended that the pressure-fed booster, series burn with liquid oxygen phase, be continued for further study. The flyback booster study was discontinued. Both solid and liquid propelled booster vehicles with 14 by 45 foot and 15 by 60 foot payload orbiters were considered.

Multi-dimensional free-electron laser simulation codes : a comparison study.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biedron, S. G.; Chae, Y. C.; Dejus, R. J.

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

Multi-Dimensional Free-Electron Laser Simulation Codes: A Comparison Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuhn, Heinz-Dieter

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

P alpha-chiral phosphorothioate analogues of bis(5'-adenosyl)tetraphosphate (Ap4A); their enzymatic synthesis and degradation.

PubMed Central

Lazewska, D; Guranowski, A

1990-01-01

Synthesis of Sp and Rp diastereomers of Ap4A alpha S has been characterized in two enzymatic systems, the lysyl-tRNA synthetase from Escherichia coli and the Ap4A alpha, beta-phosphorylase from Saccharomyces cerevisiae. The synthetase was able to use both (Sp)ATP alpha S and (Rp)ATP alpha S as acceptors of adenylate thus yielding corresponding monothioanalogues of Ap4A,(Sp) Ap4A alpha S and (Rp)Ap4A alpha S. No dithiophosphate analogue was formed. Relative synthetase velocities of the formation of Ap4A,(Sp) Ap4A alpha S and (Rp)Ap4A alpha S were 1:0.38:0.15, and the computed Km values for (Sp)ATP alpha S and (Rp)ATP alpha S were 0.48 and 1.34 mM, respectively. The yeast Ap4A phosphorylase synthesized (Sp)Ap4A alpha S and (Rp)Ap4A alpha S using adenosine 5'-phosphosulfate (APS) as source of adenylate. The adenylate was accepted by corresponding thioanalogues of ATP. In that system, relative velocities of Ap4A, (Sp)Ap4A alpha S and (Rp)Ap4A alpha S formation were 1:0.15:0.60. The two isomeric phosphorothioate analogues of Ap4A were tested as substrates for the following specific Ap4A-degrading enzymes: (asymmetrical) Ap4A hydrolase (EC 3.6.1.17) from yellow lupin (Lupinus luteus) seeds hydrolyzed each of the analogues to AMP and the corresponding isomer of ATP alpha S; (symmetrical) Ap4A hydrolase (EC 3.6.1.41) from E. coli produced ADP and the corresponding diastereomer of ADP alpha S; and Ap4A phosphorylase (EC 2.7.7.53) from S. cerevisiae cleaved the Rp isomer only at the unmodified end yielding ADP and (Rp)ATP alpha S whereas the Sp isomer was degraded non-specifically yielding a mixture of ADP, (Sp)ADP alpha S, ATP and (Sp)ATP alpha S. For all the Ap4A-degrading enzymes, the Rp isomer of Ap4A alpha S appeared to be a better substrate than its Sp counterpart; stereoselectivity of the three enzymes for the Ap4A alpha S diastereomers is 51, 6 and 2.5, respectively. Basic kinetic parameters of the degradation reactions are presented and structural requirements of the Ap4A-metabolizing enzymes with respect to the potential substrates modified at the Ap4A-P alpha are discussed. PMID:2172926

Human Pathogen Shown to Cause Disease in the Threatened Eklhorn Coral Acropora palmata

PubMed Central

Sutherland, Kathryn Patterson; Shaban, Sameera; Joyner, Jessica L.; Porter, James W.; Lipp, Erin K.

2011-01-01

Coral reefs are in severe decline. Infections by the human pathogen Serratia marcescens have contributed to precipitous losses in the common Caribbean elkhorn coral, Acropora palmata, culminating in its listing under the United States Endangered Species Act. During a 2003 outbreak of this coral disease, called acroporid serratiosis (APS), a unique strain of the pathogen, Serratia marcescens strain PDR60, was identified from diseased A. palmata, human wastewater, the non-host coral Siderastrea siderea and the corallivorous snail Coralliophila abbreviata. In order to examine humans as a source and other marine invertebrates as vectors and/or reservoirs of the APS pathogen, challenge experiments were conducted with A. palmata maintained in closed aquaria to determine infectivity of strain PDR60 from reef and wastewater sources. Strain PDR60 from wastewater and diseased A. palmata caused disease signs in elkhorn coral in as little as four and five days, respectively, demonstrating that wastewater is a definitive source of APS and identifying human strain PDR60 as a coral pathogen through fulfillment of Koch's postulates. A. palmata inoculated with strain PDR60 from C. abbreviata showed limited virulence, with one of three inoculated fragments developing APS signs within 13 days. Strain PDR60 from non-host coral S. siderea showed a delayed pathogenic effect, with disease signs developing within an average of 20 days. These results suggest that C. abbreviata and non-host corals may function as reservoirs or vectors of the APS pathogen. Our results provide the first example of a marine “reverse zoonosis” involving the transmission of a human pathogen (S. marcescens) to a marine invertebrate (A. palmata). These findings underscore the interaction between public health practices and environmental health indices such as coral reef survival. PMID:21858132

VizieR Online Data Catalog: z>~5 AGN in Chandra Deep Field-South (Weigel+, 2015)

NASA Astrophysics Data System (ADS)

Weigel, A. K.; Schawinski, K.; Treister, E.; Urry, C. M.; Koss, M.; Trakhtenbrot, B.

2015-09-01

The Chandra 4-Ms source catalogue by Xue et al. (2011, Cat. J/ApJS/195/10) is the starting point of this work. It contains 740 sources and provides counts and observed frame fluxes in the soft (0.5-2keV), hard (2-8keV) and full (0.5-8keV) band. All object IDs used in this work refer to the source numbers listed in the Xue et al. (2011, Cat. J/ApJS/195/10) Chandra 4-Ms catalogue. We make use of Hubble Space Telescope (HST)/Advanced Camera for Surveys (ACS) data from the Great Observatories Origins Deep Survey South (GOODS-south) in the optical wavelength range. We use catalogues and images for filters F435W (B), F606W (V), F775W (i) and 850LP (z) from the second GOODS/ACS data release (v2.0; Giavalisco et al., 2004, Cat. II/261). We use Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) Wide Field Camera 3 (WFC3)/infrared data from the first data release (DR1, v1.0) for passbands F105W (Y), F125W (J) and F160W (H) (Grogin et al., 2011ApJS..197...35G; Koekemoer et al., 2011ApJS..197...36K). To determine which objects are red, dusty, low-redshift interlopers, we also include the 3.6 and 4.5 micron Spitzer Infrared Array Camera (IRAC) channels. We use SIMPLE image data from the DR1 (van Dokkum et al., 2005, Spitzer Proposal, 2005.20708) and the first version of the extended SIMPLE catalogue by Damen et al. (2011, Cat. J/ApJ/727/1). (6 data files).

ROLES OF ADIPOCYTES AND FIBROBLASTS IN ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT IN INFLAMMATORY ARTHRITIS IN MICE

PubMed Central

Arend, William P.; Mehta, Gaurav; Antonioli, Alexandra H.; Takahashi, Minoru; Takahashi, Kazue; Stahl, Gregory L.; Holers, V. Michael; Banda, Nirmal K.

2013-01-01

The complement system is involved in mediation of joint damage in rheumatoid arthritis, with evidence suggesting activation of both the classical and alternative pathways (AP). The AP is both necessary and sufficient to mediate collagen antibody-induced arthritis (CAIA), an experimental animal model of immune complex (IC)-induced joint disease. The AP in mice is dependent on MASP-1/3 cleavage of pro-factor D (pro-FD) into mature FD. The objectives of the present study were to determine the cells synthesizing MASP-1/3 and pro-FD in synovial tissue. CAIA was studied in wild-type C57BL/6 mice, and the localization of mRNA and protein for FD and MASP-1/3 in synovial adipose tissue (SAT) and fibroblast-like synoviocytes (FLS) was determined using various techniques, including laser capture micro-dissection (LCM). SAT was the sole source of mRNA for pro-FD. Cultured differentiated 3T3 adipocytes, a surrogate for SAT, produced pro-FD but no mature FD. FLS were the main source of MASP-1/3 mRNA and protein. Using cartilage micro-particles (CMP) coated with anti-collagen mAb and serum from MASP-1/3−/− mice as a source of factor B, pro-FD in 3T3 supernatants was cleaved into mature FD by MASP-1/3 in FLS supernatants. The mature FD was eluted from the CMP, and was not present in the supernatants from the incubation with CMP, indicating that cleavage of pro-FD into mature FD by MASP-1 occurred on the CMP. These results demonstrate that pathogenic activation of the AP may occur in the joint through IC adherent to cartilage and the local production of necessary AP proteins by adipocytes and FLS. PMID:23650618

Five-Segment Reusable Solid Rocket Booster Upgrade

NASA Technical Reports Server (NTRS)

Sauvageau, Don

1999-01-01

The Five Segment Reusable Solid Rocket Booster (RSRB) feasibility status is presented in viewgraph form. The Five Segment Booster (FSB) objective is to provide a low cost, low risk approach to increase reliability and safety of the Shuttle system. Topics include: booster upgrade requirements; design summary; reliability issues; booster trajectories; launch site assessment; and enhanced abort modes.

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

Analysis of child passenger safety restraint use at a pediatric emergency department.

PubMed

Cease, Alan T; King, William D; Monroe, Kathy W

2011-02-01

The objectives of the study were to determine the number of children properly restrained during transit to a pediatric emergency department for care and to ascertain parental knowledge of Alabama laws and American Academy of Pediatrics (AAP) guidelines and where they obtain this information. An emergency department (patient care rooms) waiting area, convenience sample of Alabama parents who have children younger than or 13 years of age were surveyed over a 5-week period. Appropriate use of child passenger safety (CPS) restraints was determined using Alabama law and AAP recommendations. Use of Car Seat Checks provided by Children's Hospital and Safe Kids, knowledge of Alabama laws and CPS guidelines, and the source of information used by parents were ascertained. Among 525 patients identified, 520 (99.0%) participated. Appropriate use per Alabama law and AAP guidelines was 72.3% and 60.6%, respectively; 5.0% were unrestrained. Booster seats were the most commonly misused restraint. Car seats were reportedly used correctly by 81.9%. Parents who had used the Car Seat Checks program had correct booster seat and car seat use rates of 95.8% and 61.5%, respectively. Unfortunately, only 31.2% of patients had knowledge of the Car Seat Checks program, and only 40.6% knew the current law. Most often, parents stated that the hospital where their child was born was the primary (and sometimes only) source of CPS information. This study illustrates the need for improving parental knowledge of appropriate child passenger restraint use (especially booster seats) and Car Seat Checks programs. Car seat program assistance is associated with high levels of appropriate use.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frølich, S.; Leemreize, H.; Jakus, A.

A model sample consisting of two different hydroxyapatite (hAp) powders was used as a bone phantom to investigate the extent to which X-ray diffraction tomography could map differences in hAp lattice constants and crystallite size. The diffraction data were collected at beamline 1-ID, the Advanced Photon Source, using monochromatic 65 keV X-radiation, a 25 × 25 µm pinhole beam and translation/rotation data collection. The diffraction pattern was reconstructed for each volume element (voxel) in the sample, and Rietveld refinement was used to determine the hAp lattice constants. The crystallite size for each voxel was also determined from the 00.2 hApmore » diffraction peak width. The results clearly show that differences between hAp powders could be measured with diffraction tomography.« less

Alternate Lattice Design for Advanced Photon Source Multi-Bend Achromat Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Yipeng; Borland, Michael

2015-01-01

A 67-pm hybrid-seven-bend achromat (H7BA) lattice is proposed for a futureAdvanced Photon Source (APS)multibend- achromat (MBA) upgrade. This lattice requires use of a swap-out (on-axis) injection scheme. Alternate lattice design work has also been performed to achieve better beam dynamics performance than the nominal APS MBA lattice, in order to allow beam accumulation. One of such alternate H7BA lattice designs, which still targets a very low emittance of 76 pm, is discussed in this paper. With these lattices, existing APS injector complex can be employed without the requirement of a very high charge operation. Studies show that an emittance belowmore » 76 pm can be achieved with the employment of reverse bends in an alternate lattice. We discuss the predicted performance and requirements for these lattices and compare them to the nominal lattice.« less

VizieR Online Data Catalog: Sample of Fermi Blazars (Chen+, 2016)

NASA Astrophysics Data System (ADS)

Chen, Y.-Y.; Zhang, X.; Xiong, D.-R.; Wang, S.-J.; Yu, X.-L.

2016-04-01

We tried to select a large number of blazars with reliable redshift, radio core and extended radio luminosity at 1.4GHz. Firstly, we considered the following samples of blazars to get the radio core luminosity and extended luminosity at 1.4GHz: Kharb et al. (2010, J/ApJ/710/764), Antonucci & Ulvestad (1985ApJ...294..158A), Cassaro et al. (1999A&AS..139..601C), Murphy et al. (1993MNRAS.264..298M), Landt & Bignall (2008MNRAS.391..967L), Caccianiga & Marcha (2004, Cat. J/MNRAS/348/973), Giroletti et al. (2004). We cross-correlated these samples with the Fermi LAT Third Source Catalog (3FGL), and we acquired the 3FGL spectral index and energy flux at 0.1-100GeV from clean sources in 3FGL (Fermi-LAT Collaboration 2015, J/ApJS/218/23) Using these catalogs, we compiled 201 Fermi blazars. (1 data file).

VizieR Online Data Catalog: X-ray+Radio sources in XBootes (El Bouchefry, 2009)

NASA Astrophysics Data System (ADS)

El Bouchefry, K.

2010-08-01

The radio data are from the 2002 version of the FIRST VLA catalogue (Becker et al., 1995, See Cat. VIII/71), and it is derived from 1993 through 2002 observations. The X-ray data (Kenter et al. 2005, Cat. J/ApJS/161/9; Murray et al. 2005ApJS..161....1M) used in this paper are from the Chandra XBootes surveys. The XBootes catalogue contains ~3213 X-ray point sources and is publicly available through the National Optical Astronomy Observatory (NOAO) Deep Wide Field Survey (NDWFS) homepage (http://www.noao.edu/noao/noaodeep/XBootesPublic/index.html) The NDWFS is a deep multiband imaging (Bw, R, I, J, H, K) designed to study the formation and evolution of large-scale structures (Jannuzi et al., 1999, BAAS, 31, 1392; Brown et al., 2003ApJ...597..225B). (1 data file).

Emulsion based cast booster - a priming system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, R.N.; Mishra, A.K.

2005-07-01

This paper explores the potential of emulsion based cast booster to be used as primer to initiate bulk delivered emulsion explosives used in mines. An attempt has been made for comparative study between conventional cast booster and emulsion based cast booster in terms of the initiation process developed and their capability to develop and maintain the stable detonation process in the column explosives. The study has been conducted using a continuous velocity of detonation (VOD) measuring instrument. During this study three blasts have been monitored. In each blast two holes have been selected for study, the first hole being initiatedmore » with conventional cast booster while the other one with emulsion based cast booster. The findings of the study advocates that emulsion based cast booster is capable of efficient priming of bulk delivered column explosive with stable detonation process in the column. Further, the booster had advantages over the conventional PETN/TNT based cast booster. 5 refs., 2 figs., 1 tab., 1 photo.« less

47 CFR 74.15 - Station license period.

Code of Federal Regulations, 2011 CFR

2011-10-01

... broadcast booster station or a TV broadcast booster station will be issued for a period running concurrently... broadcast station, FM translator or FM broadcast booster, TV translator or TV broadcast booster, or low...

47 CFR 74.15 - Station license period.

Code of Federal Regulations, 2012 CFR

2012-10-01

... broadcast booster station or a TV broadcast booster station will be issued for a period running concurrently... broadcast station, FM translator or FM broadcast booster, TV translator or TV broadcast booster, or low...

Simulation of Turbulent Combustion Fields of Shock-Dispersed Aluminum Using the AMR Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuhl, A L; Bell, J B; Beckner, V E

2006-11-02

We present a Model for simulating experiments of combustion in Shock-Dispersed-Fuel (SDF) explosions. The SDF charge consisted of a 0.5-g spherical PETN booster, surrounded by 1-g of fuel powder (flake Aluminum). Detonation of the booster charge creates a high-temperature, high-pressure source (PETN detonation products gases) that both disperses the fuel and heats it. Combustion ensues when the fuel mixes with air. The gas phase is governed by the gas-dynamic conservation laws, while the particle phase obeys the continuum mechanics laws for heterogeneous media. The two phases exchange mass, momentum and energy according to inter-phase interaction terms. The kinetics model usedmore » an empirical particle burn relation. The thermodynamic model considers the air, fuel and booster products to be of frozen composition, while the Al combustion products are assumed to be in equilibrium. The thermodynamic states were calculated by the Cheetah code; resulting state points were fit with analytic functions suitable for numerical simulations. Numerical simulations of combustion of an Aluminum SDF charge in a 6.4-liter chamber were performed. Computed pressure histories agree with measurements.« less

Investigation of Post-Flight Solid Rocket Booster Thermal Protection System

NASA Technical Reports Server (NTRS)

Nelson, Linda A.

2006-01-01

After every Shuttle mission, the Solid Rocket Boosters (SRBs) are recovered and observed for missing material. Most of the SRB is covered with a cork-based thermal protection material (MCC-l). After the most recent shuttle mission, STS-114, the forward section of the booster appeared to have been impacted during flight. The darkened fracture surfaces indicated that this might have occurred early in flight. The scope of the analysis included microscopic observations to assess the degree of heat effects and locate evidence of the impact source as well as chemical analysis of the fracture surfaces and recovered foreign material using Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy/Energy Dispersive Spectroscopy. The amount of heat effects and presence of soot products on the fracture surface indicated that the material was impacted prior to SRB re-entry into the atmosphere. Fragments of graphite fibers found on these fracture surfaces were traced to slag inside the Solid Rocket Motor (SRM) that forms during flight as the propellant is spent and is ejected throughout the descent of the SRB after separation. The direction of the impact mark matches with the likely trajectory of SRBs tumbling prior to re-entry.

Hybrid propulsion technology program. Volume 2: Technology definition package

NASA Technical Reports Server (NTRS)

Jensen, Gordon E.; Holzman, Allen L.; Leisch, Steven O.; Keilbach, Joseph; Parsley, Randy; Humphrey, John

1989-01-01

A concept design study was performed to configure two sizes of hybrid boosters; one which duplicates the advanced shuttle rocket motor vacuum thrust time curve and a smaller, quarter thrust level booster. Two sizes of hybrid boosters were configured for either pump-fed or pressure-fed oxygen feed systems. Performance analyses show improved payload capability relative to a solid propellant booster. Size optimization and fuel safety considerations resulted in a 4.57 m (180 inch) diameter large booster with an inert hydrocarbon fuel. The preferred diameter for the quarter thrust level booster is 2.53 m (96 inches). The demonstration plan would culminate with test firings of a 3.05 m (120 inch) diameter hybrid booster.

47 CFR 73.3500 - Application and report forms.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., TV Translator or TV Booster Station. 347 Application for a Low Power TV, TV Translator or TV Booster... Booster Station. 350 Application for an FM Translator or FM Booster Station License. 395-B Annual...

47 CFR 73.3500 - Application and report forms.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., TV Translator or TV Booster Station. 347 Application for a Low Power TV, TV Translator or TV Booster... Booster Station. 350 Application for an FM Translator or FM Booster Station License. 395-B Annual...

47 CFR 73.3500 - Application and report forms.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., TV Translator or TV Booster Station. 347 Application for a Low Power TV, TV Translator or TV Booster... Booster Station. 350 Application for an FM Translator or FM Booster Station License. 395-B Annual...

47 CFR 73.3500 - Application and report forms.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., TV Translator or TV Booster Station. 347 Application for a Low Power TV, TV Translator or TV Booster... Booster Station. 350 Application for an FM Translator or FM Booster Station License. 395-B Annual...

A 10 Day Period in IGR J16328-4726 from Swift/BAT Observations

NASA Astrophysics Data System (ADS)

Corbet, R. H. D.; Barthelmy, S. D.; Baumgartner, W. H.; Krimm, H. A.; Markwardt, C. B.; Skinner, G. K.; Tueller, J.

2010-04-01

IGR J16328-4726 is a little studied X-ray source. It is listed as a "blended" variable source in the 4th IBIS/ISGRI Catalog (Bird et al. 2010, ApJ Supp, 186, 1) but is not present in the Swift BAT 22 month all-sky survey (Tueller et al. 2010, ApJ Supp, 186, 378). Grupe et al. (2009, ATel #2075) report a flare detected with the Swift BAT which was followed up with Swift XRT observations. We have analyzed the Swift BAT 58 month survey (Baumgartner et al.

Hard X-Rays can BE Used to Visualize Cochlear Soft Tissue Displacements in a Closed Cochlea

NASA Astrophysics Data System (ADS)

Richter, C.-P.; Fishman, A.; Fan, L.; Shintani, S.; Rau, C.

2009-02-01

Experiments were made at the Advanced Photon Source (APS), Argonne National Laboratory. The APS is a synchrotron radiation source of the third generation, for which the particular characteristic is the highly coherent X-ray radiation. X-rays are generated with an undulator, inserted in a straight section of the storage ring. Images taken with hard X-rays at full field. A video flow algorithm by Lucas and Kanade was used to determine and quantify cochlear soft tissue displacements. The results show that displacements as low as 100 nm could be visualized.

Two Amazing Rocket Launches That Began My Career

NASA Astrophysics Data System (ADS)

Rothschild, Richard E.

2013-01-01

I began my X-ray astronomy career by being given the responsibility for the Goddard rocket program by Frank MacDonald in the early 70's. I am forever grateful to him and Elihu Boldt for the opportunity. The rocket's observing program was three compact binary X-ray sources that could not have been more different: Cyg X-1, Cyg X-3, and Her X-1. A sounding rocket launch is nothing like a satellite launch with its large booster, Cape Canaveral experience, and lots of procedures and no touching of the hardware. First of all, one can walk up to the sounding rocket tower (at least you used to be able to) and go up in it to fix or adjust something with the yet-to-be-fueled rocket, booster, and payload just sitting there. At launch, you can see it up close 100 m) and personal, and it is spectacular. There is an explosion (the Nike booster igniting), a bright flash of light, and it is gone in a second or two. And back in the block house, I watched Her X-1 pulse in real time, after Chuck Glasser calmed me down and explained that the detectors were not arcing but it was Her X-1. The Cyg X-1 observations resulted in the discovery of millisecond temporal structure in the flux from a cosmic source -- 13 1-ms bursts over a total of two minutes of observing in the 2 flights. Cyg X-3 was seen in a high state in the first flight and in a lower harder state in the second, where we detected the iron line for the first time in a Galactic source. The Her X-1 observation clearly showed the high energy roll-over of the spectrum for the first time. The light curves of the first flight found their way into many presentations, including Ricardo Giacconi's Nobel lecture. The Goddard rocket program was an amazing beginning to my career.

KSC-2009-2144

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – The Solid Rocket Booster Retrieval Ship Liberty Star tows a booster to the dock at Hangar AF at Cape Canaveral Air Force Station in Florida. The booster was used during space shuttle Discovery's launch from NASA's Kennedy Space Center in Florida March 15 on mission STS-119. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-2009-2141

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – The Solid Rocket Booster Retrieval Ship Liberty Star tows a booster to the dock at Hangar AF at Cape Canaveral Air Force Station in Florida. The booster was used during space shuttle Discovery's launch from NASA's Kennedy Space Center in Florida March 15 on mission STS-119. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

Preclinical medical students' understandings of academic and medical professionalism: visual analysis of mind maps.

PubMed

Janczukowicz, Janusz; Rees, Charlotte E

2017-08-18

Several studies have begun to explore medical students' understandings of professionalism generally and medical professionalism specifically. Despite espoused relationships between academic (AP) and medical professionalism (MP), previous research has not yet investigated students' conceptualisations of AP and MP and the relationships between the two. The current study, based on innovative visual analysis of mind maps, therefore aims to contribute to the developing literature on how professionalism is understood. We performed a multilayered analysis of 98 mind maps from 262 first-year medical students, including analysing textual and graphical elements of AP, MP and the relationships between AP and MP. The most common textual attributes of AP were learning, lifestyle and personality, while attributes of MP were knowledge, ethics and patient-doctor relations. Images of books, academic caps and teachers were used most often to represent AP, while images of the stethoscope, doctor and red cross were used to symbolise MP. While AP-MP relations were sometimes indicated through co-occurring text, visual connections and higher-order visual metaphors, many students struggled to articulate the relationships between AP and MP. While the mind maps' textual attributes shared similarities with those found in previous research, suggesting the universality of some professionalism attributes, our study provides new insights into students' conceptualisations of AP, MP and AP-MP relationships. We encourage medical educators to help students develop their understandings of AP, MP and AP-MP relationships, plus consider the feasibility and value of mind maps as a source of visual data for medical education research. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Pressure-Equalizing Cradle for Booster Rocket Mounting

NASA Technical Reports Server (NTRS)

Rutan, Elbert L. (Inventor)

2015-01-01

A launch system and method improve the launch efficiency of a booster rocket and payload. A launch aircraft atop which the booster rocket is mounted in a cradle, is flown or towed to an elevation at which the booster rocket is released. The cradle provides for reduced structural requirements for the booster rocket by including a compressible layer, that may be provided by a plurality of gas or liquid-filled flexible chambers. The compressible layer contacts the booster rocket along most of the length of the booster rocket to distribute applied pressure, nearly eliminating bending loads. Distributing the pressure eliminates point loading conditions and bending moments that would otherwise be generated in the booster rocket structure during carrying. The chambers may be balloons distributed in rows and columns within the cradle or cylindrical chambers extending along a length of the cradle. The cradle may include a manifold communicating gas between chambers.

Cost-Effectiveness of Adolescent Pertussis Vaccination for The Netherlands: Using an Individual-Based Dynamic Model

PubMed Central

de Vries, Robin; Kretzschmar, Mirjam; Schellekens, Joop F. P.; Versteegh, Florens G. A.; Westra, Tjalke A.; Roord, John J.; Postma, Maarten J.

2010-01-01

Background Despite widespread immunization programs, a clear increase in pertussis incidence is apparent in many developed countries during the last decades. Consequently, additional immunization strategies are considered to reduce the burden of disease. The aim of this study is to design an individual-based stochastic dynamic framework to model pertussis transmission in the population in order to predict the epidemiologic and economic consequences of the implementation of universal booster vaccination programs. Using this framework, we estimate the cost-effectiveness of universal adolescent pertussis booster vaccination at the age of 12 years in the Netherlands. Methods/Principal Findings We designed a discrete event simulation (DES) model to predict the epidemiological and economic consequences of implementing universal adolescent booster vaccination. We used national age-specific notification data over the period 1996–2000—corrected for underreporting—to calibrate the model assuming a steady state situation. Subsequently, booster vaccination was introduced. Input parameters of the model were derived from literature, national data sources (e.g. costing data, incidence and hospitalization data) and expert opinions. As there is no consensus on the duration of immunity acquired by natural infection, we considered two scenarios for this duration of protection (i.e. 8 and 15 years). In both scenarios, total pertussis incidence decreased as a result of adolescent vaccination. From a societal perspective, the cost-effectiveness was estimated at €4418/QALY (range: 3205–6364 € per QALY) and €6371/QALY (range: 4139–9549 € per QALY) for the 8- and 15-year protection scenarios, respectively. Sensitivity analyses revealed that the outcomes are most sensitive to the quality of life weights used for pertussis disease. Conclusions/Significance To our knowledge we designed the first individual-based dynamic framework to model pertussis transmission in the population. This study indicates that adolescent pertussis vaccination is likely to be a cost-effective intervention for The Netherlands. The model is suited to investigate further pertussis booster vaccination strategies. PMID:20976213

Misuse of booster cushions among children and adults in Shanghai-an observational and attitude study during buckling up.

PubMed

Bohman, Katarina; Jorlöv, Sofia; Zhou, Shengqi; Zhao, Cloud; Sui, Bo; Ding, Chengkai

2016-10-02

Traffic crashes are one of the leading causes of fatalities among Chinese children. Booster cushion usage in China is low, and there are no studies showing how a population with limited experience handles booster cushions during buckling up. The purpose of this study was to evaluate the handling of and explore the attitudes toward booster cushions among children, parents, and grandparents in Shanghai. An observational study including a convenience sample of 254 children aged 4-12 years was conducted in 2 passenger cars at a shopping center in Shanghai. Parents, grandparents, or the children themselves buckled up the child on 2 types of booster cushions, a 2-stage integrated booster cushion (IBC) and an aftermarket booster cushion (BC). The test participants were observed during buckling up, first without and then with instructions. The test leaders conducted structured interviews. Ninety-eight percent of the uninstructed participants failed to buckle up without identified misuse on the aftermarket booster cushion and 31% of those uninstructed on the integrated booster cushion. The majority of misuse was severe, including placing the belt behind the arm and the lap belt routing above the guiding loops. Instruction reduced misuse to 58% (BC) and 12% (IBC), respectively, and, in particular, severe misuse. Some misuse was related to limited knowledge of how to buckle up on the booster cushion, and some misuse was intentional in order to reduce discomfort. The participants, both children and adults, reported that they preferred the IBC due to good comfort and convenience. Safety was reported as the main reason for adults using booster cushions in general, whereas children reported comfort as the most important motivation. Education is needed to ensure frequent and correct use of booster cushions in China and to raise safety awareness among children and adults. Furthermore, it is important that the booster cushions offer intuitively correct usage to a population with limited experience of booster cushions. This is the first study published on the handling of and attitude toward booster cushions after child restraints laws were introduced in Shanghai 2014.

Three Bright X-ray Sources in NGC 1313

NASA Astrophysics Data System (ADS)

Colbert, E.; Petre, R.; Schlegel, E.

1992-12-01

Three bright X-ray sources were detected in a recent (April/May 1991) ROSAT PSPC observation of the nearby (D ~ 4.5 Mpc) face--on barred spiral galaxy NGC 1313. Two of the sources were at positions coincident with X-ray sources detected by Fabbiano & Trinchieri (ApJ 315, 1987) in a previous (Jan 1980) Einstein IPC observation. The position of the brightest Einstein source is near the center of NGC 1313, and the second Einstein source is ~ 7' south of the ``nuclear'' source, in the outskirts of the spiral arms. A third bright X-ray source was detected in the ROSAT observation ~ 7' southwest of the ``nuclear'' source. We present X-ray spectra and X-ray images for the three bright sources found in the ROSAT observation of NGC 1313, and compare with previous Einstein results. Spectral analysis of these sources require them to have very large soft X-ray luminosities ( ~ 10(40) erg s(-1) ) when compared with typical X-ray sources in our Galaxy. Feasible explanations for the X-ray emission are presented. The third X-ray source is positively identified with the recently discovered (Ryder et. al., ApJ 1992) peculiar type-II supernova 1978K.

Integration of gene expression profiling of hypothalamic arcuate nucleus with genome-wide associations to discover functional variants associated with age at puberty in gilts

USDA-ARS?s Scientific Manuscript database

Age at puberty (AP) in gilts is a moderately heritable trait (h2 = 0.37) and the earliest indicator of sow reproductive longevity. Therefore, quantifying the pleiotropic sources that influence both AP and reproductive longevity is important in understanding the differences in sow fertility. In this ...

A second-generation superconducting undulator cryostat for the APS

NASA Astrophysics Data System (ADS)

Fuerst, J.; Hasse, Q.; Ivanyushenkov, Y.; Kasa, M.; Shiroyanagi, Y.

2017-12-01

A second-generation cryocooler-based cryostat has been designed and built to support a new helically wound superconducting undulator (SCU) magnet for the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). The design represents an evolution of existing SCU cryostats currently in operation in the APS storage ring. Value engineering and lessons learned have resulted in a smaller, cheaper, and simpler cryostat design compatible with existing planar magnets as well as the new helically wound device. We describe heat load and quench response results, design and operational details, and the “build-to-spec” procurement strategy.

NASA's Space Launch System Advanced Booster Engineering Demonstration and/or Risk Reduction Efforts

NASA Technical Reports Server (NTRS)

Crumbly, Christopher M.; Dumbacher, Daniel L.; May, Todd A.

2012-01-01

The National Aeronautics and Space Administration (NASA) formally initiated the Space Launch System (SLS) development in September 2011, with the approval of the program s acquisition plan, which engages the current workforce and infrastructure to deliver an initial 70 metric ton (t) SLS capability in 2017, while using planned block upgrades to evolve to a full 130 t capability after 2021. A key component of the acquisition plan is a three-phased approach for the first stage boosters. The first phase is to complete the development of the Ares and Space Shuttle heritage 5-segment solid rocket boosters (SRBs) for initial exploration missions in 2017 and 2021. The second phase in the booster acquisition plan is the Advanced Booster Risk Reduction and/or Engineering Demonstration NASA Research Announcement (NRA), which was recently awarded after a full and open competition. The NRA was released to industry on February 9, 2012, with a stated intent to reduce risks leading to an affordable advanced booster and to enable competition. The third and final phase will be a full and open competition for Design, Development, Test, and Evaluation (DDT&E) of the advanced boosters. There are no existing boosters that can meet the performance requirements for the 130 t class SLS. The expected thrust class of the advanced boosters is potentially double the current 5-segment solid rocket booster capability. These new boosters will enable the flexible path approach to space exploration beyond Earth orbit (BEO), opening up vast opportunities including near-Earth asteroids, Lagrange Points, and Mars. This evolved capability offers large volume for science missions and payloads, will be modular and flexible, and will be right-sized for mission requirements. NASA developed the Advanced Booster Engineering Demonstration and/or Risk Reduction NRA to seek industry participation in reducing risks leading to an affordable advanced booster that meets the SLS performance requirements. Demonstrations and/or risk reduction efforts were required to be related to a proposed booster concept directly applicable to fielding an advanced booster. This paper will discuss, for the first time publicly, the contract awards and how NASA intends to use the data from these efforts to prepare for the planned advanced booster DDT&E acquisition as the SLS Program moves forward with competitively procured affordable performance enhancements.

NASA's Space Launch System Advanced Booster Engineering Demonstration and Risk Reduction Efforts

NASA Technical Reports Server (NTRS)

Crumbly, Christopher M.; May, Todd; Dumbacher, Daniel

2012-01-01

The National Aeronautics and Space Administration (NASA) formally initiated the Space Launch System (SLS) development in September 2011, with the approval of the program s acquisition plan, which engages the current workforce and infrastructure to deliver an initial 70 metric ton (t) SLS capability in 2017, while using planned block upgrades to evolve to a full 130 t capability after 2021. A key component of the acquisition plan is a three-phased approach for the first stage boosters. The first phase is to complete the development of the Ares and Space Shuttle heritage 5-segment solid rocket boosters for initial exploration missions in 2017 and 2021. The second phase in the booster acquisition plan is the Advanced Booster Risk Reduction and/or Engineering Demonstration NASA Research Announcement (NRA), which was recently awarded after a full and open competition. The NRA was released to industry on February 9, 2012, and its stated intent was to reduce risks leading to an affordable Advanced Booster and to enable competition. The third and final phase will be a full and open competition for Design, Development, Test, and Evaluation (DDT&E) of the Advanced Boosters. There are no existing boosters that can meet the performance requirements for the 130 t class SLS. The expected thrust class of the Advanced Boosters is potentially double the current 5-segment solid rocket booster capability. These new boosters will enable the flexible path approach to space exploration beyond Earth orbit, opening up vast opportunities including near-Earth asteroids, Lagrange Points, and Mars. This evolved capability offers large volume for science missions and payloads, will be modular and flexible, and will be right-sized for mission requirements. NASA developed the Advanced Booster Engineering Demonstration and/or Risk Reduction NRA to seek industry participation in reducing risks leading to an affordable Advanced Booster that meets the SLS performance requirements. Demonstrations and/or risk reduction efforts were required to be related to a proposed booster concept directly applicable to fielding an Advanced Booster. This paper will discuss, for the first time publicly, the contract awards and how NASA intends to use the data from these efforts to prepare for the planned Advanced Booster DDT&E acquisition as the SLS Program moves forward with competitively procured affordable performance enhancements.

Long-term immunogenicity of an initial booster dose of an inactivated, Vero cell culture-derived Japanese encephalitis vaccine (JE-VC) and the safety and immunogenicity of a second JE-VC booster dose in children previously vaccinated with an inactivated, mouse brain-derived Japanese encephalitis vaccine.

PubMed

Yun, Ki Wook; Lee, Hoan Jong; Park, Ji Young; Cho, Hye-Kyung; Kim, Yae-Jean; Kim, Kyung-Hyo; Kim, Nam Hee; Hong, Young Jin; Kim, Dong Ho; Kim, Hwang Min; Cha, Sung-Ho

2018-03-07

This study was performed with the aim of determining the long-term immunogenicity of an inactivated, Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) and an inactivated, mouse brain-derived JE vaccine (JE-MB) after the 1st booster dose at 2 years of age, as well as the safety and immunogenicity of the 2nd booster dose of JE-VC at 6 years of age, in children primed and given a 1st booster dose of either JE-VC or JE-MB. In this multicenter, open-label clinical trial, the study population consisted of healthy Korean children (aged 6 years) who participated in the previous JE vaccine trial. All subjects were subcutaneously vaccinated once for the booster immunization with Boryung Cell Culture Japanese Encephalitis Vaccine® (JE-VC). Approximately 4 years after the 1st booster dose of JE-VC, the seroprotection rate (SPR) and geometric mean titer (GMT) of the neutralizing antibody were 100% and 1113.8, respectively. In children primed and given a 1st booster dose of JE-MB, the SPR and GMT were 88.5% and 56.3, respectively. After the 2nd booster dose of JE-VC, all participants primed and given a 1st booster dose of either JE-MB or JE-VC were seroprotective against JE virus. The GMT of the neutralizing antibody was higher in children primed and given a 1st booster dose of JE-VC (8144.1) than in those primed and given a 1st booster dose of JE-MB (942.5) after the vaccination (p < 0.001). In addition, the 2nd booster dose of JE-VC showed a good safety profile with no serious vaccine-related adverse events. The 1st booster dose of JE-VC and JE-MB showed long-term immunogenicity of at least 4 years, and the 2nd booster dose of JE-VC showed a good safety and immunogenicity profile in children primed and given a 1st booster dose of either JE-VC or JE-MB. ClinicalTtrials.gov Identifier: NCT02532569. Copyright © 2018 Elsevier Ltd. All rights reserved.

KSC-08pd0736

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, motors through Port Canaveral with a solid rocket booster alongside. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0741

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, nears Hangar AF at Cape Canaveral Air Force Station with a solid rocket booster alongside. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0738

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, crosses through the drawbridge over the Haulover Canal into the Banana River. The ship is towing a solid rocket booster alongside. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0740

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, tows a solid rocket booster alongside, heading for Hangar AF at Cape Canaveral Air Force Station. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0737

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, motors through Port Canaveral with a solid rocket booster alongside. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

Characterization of alkaline phosphatase activity in seminal plasma and in fresh and frozen-thawed stallion spermatozoa.

PubMed

Bucci, Diego; Giaretta, Elisa; Spinaci, Marcella; Rizzato, Giovanni; Isani, Gloria; Mislei, Beatrice; Mari, Gaetano; Tamanini, Carlo; Galeati, Giovanna

2016-01-15

Alkaline phosphatase (AP) has been studied in several situations to elucidate its role in reproductive biology of the male from different mammalian species; at present, its role in horse sperm physiology is not clear. The aim of the present work was to measure AP activity in seminal plasma and sperm extracts from freshly ejaculated as well as in frozen-thawed stallion spermatozoa and to verify whether relationship exists between AP activity and sperm quality parameters. Our data on 40 freshly ejaculated samples from 10 different stallions demonstrate that the main source of AP activity is seminal plasma, whereas sperm extracts contribution is very low. In addition, we found that AP activity at physiological pH (7.0) is significantly lower than that observed at pH 8.0, including the optimal AP pH (pH 10.0). Alkaline phosphatase did not exert any effect on sperm-oocyte interaction assessed by heterologous oocyte binding assay. Additionally, we observed a thermal stability of seminal plasma AP, concluding that it is similar to that of bone isoforms. Positive correlations were found between seminal plasma AP activity and sperm concentration, whereas a negative correlation was present between both spermatozoa extracts and seminal plasma AP activity and seminal plasma protein content. A significant decrease in sperm extract AP activity was found in frozen-thawed samples compared with freshly ejaculated ones (n = 21), concomitantly with the decrease in sperm quality parameters. The positive correlation between seminal plasma AP activity measured at pH 10 and viability of frozen-thawed spermatozoa suggests that seminal plasma AP activity could be used as an additional predictive parameter for stallion sperm freezability. In conclusion, we provide some insights into AP activity in both seminal plasma and sperm extracts and describe a decrease in AP after freezing and thawing. Copyright © 2016 Elsevier Inc. All rights reserved.

Study of current-mode active pixel sensor circuits using amorphous InSnZnO thin-film transistor for 50-μm pixel-pitch indirect X-ray imagers

NASA Astrophysics Data System (ADS)

Cheng, Mao-Hsun; Zhao, Chumin; Kanicki, Jerzy

2017-05-01

Current-mode active pixel sensor (C-APS) circuits based on amorphous indium-tin-zinc-oxide thin-film transistors (a-ITZO TFTs) are proposed for indirect X-ray imagers. The proposed C-APS circuits include a combination of a hydrogenated amorphous silicon (a-Si:H) p+-i-n+ photodiode (PD) and a-ITZO TFTs. Source-output (SO) and drain-output (DO) C-APS are investigated and compared. Acceptable signal linearity and high gains are realized for SO C-APS. APS circuit characteristics including voltage gain, charge gain, signal linearity, charge-to-current conversion gain, electron-to-voltage conversion gain are evaluated. The impact of the a-ITZO TFT threshold voltage shifts on C-APS is also considered. A layout for a pixel pitch of 50 μm and an associated fabrication process are suggested. Data line loadings for 4k-resolution X-ray imagers are computed and their impact on circuit performances is taken into consideration. Noise analysis is performed, showing a total input-referred noise of 239 e-.

Exopolysaccharide-producing lactic acid bacteria strains from traditional Thai fermented foods: isolation, identification and exopolysaccharide characterization.

PubMed

Smitinont, T; Tansakul, C; Tanasupawat, S; Keeratipibul, S; Navarini, L; Bosco, M; Cescutti, P

1999-10-15

Lactic Acid Bacteria (LAB) isolated from various traditional Thai fermented foods were screened for exopolysaccharides (EPS) production. From 104 isolates, two rod-shaped and five coccal-shaped LAB were able to produce EPS from sucrose on solid media. However, only the cocci were capable of producing EPS in liquid media and these were identified as Pediococcus pentosaceus. Pediococcus pentosaceus strains AP-1 and AP-3 produced EPS in high yield. In liquid media containing sucrose as carbon source, the amount of EPS produced by AP-1 and AP-3 strains was 6.0 and 2.5 g/L, respectively. The isolated and purified EPSs were chemically characterized. On the basis of sugar composition, methylation analysis and nuclear magnetic resonance spectroscopy, both the EPSs were shown to belong to the same dextran class. In particular, both EPSs differed from linear dextran by branching through 3,6-di-Osubstituted alpha-D-glucopyranosyl residues. The EPS from P. pentosaceus AP-3 was characterized by a relatively higher degree of branching and by a higher molecular weight than that from P. pentosaceus AP-1.

Space Launch System NASA Research Announcement Advanced Booster Engineering Demonstration and/or Risk Reduction

NASA Technical Reports Server (NTRS)

Crumbly, Christopher M.; Craig, Kellie D.

2011-01-01

The intent of the Advanced Booster Engineering Demonstration and/or Risk Reduction (ABEDRR) effort is to: (1) Reduce risks leading to an affordable Advanced Booster that meets the evolved capabilities of SLS (2) Enable competition by mitigating targeted Advanced Booster risks to enhance SLS affordability. Key Concepts (1) Offerors must propose an Advanced Booster concept that meets SLS Program requirements (2) Engineering Demonstration and/or Risk Reduction must relate to the Offeror s Advanced Booster concept (3) NASA Research Announcement (NRA) will not be prescriptive in defining Engineering Demonstration and/or Risk Reduction

StarBooster Demonstrator Cluster Configuration Analysis/Verification Program

NASA Technical Reports Server (NTRS)

DeTurris, Dianne J.

2003-01-01

In order to study the flight dynamics of the cluster configuration of two first stage boosters and upper-stage, flight-testing of subsonic sub-scale models has been undertaken using two glideback boosters launched on a center upper-stage. Three high power rockets clustered together were built and flown to demonstrate vertical launch, separation and horizontal recovery of the boosters. Although the boosters fly to conventional aircraft landing, the centerstage comes down separately under its own parachute. The goal of the project has been to collect data during separation and flight for comparison with a six degree of freedom simulation. The configuration for the delta wing canard boosters comes from a design by Starcraft Boosters, Inc. The subscale rockets were constructed of foam covered in carbon or fiberglass and were launched with commercially available solid rocket motors. The first set of boosters built were 3-ft tall with a 4-ft tall centerstage, and two additional sets of boosters were made that were each over 5-ft tall with a 7.5 ft centerstage. The rocket cluster is launched vertically, then after motor bum out the boosters are separated and flown to a horizontal landing under radio-control. An on-board data acquisition system recorded data during both the launch and glide phases of flight.

KSC-08pd3731

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – NASA's Solid Rocket Booster Retrieval Ship Freedom Star arrives at the dock at Hangar AF, Cape Canaveral Air Force Station in Florida, with a spent solid rocket booster alongside. The booster is from space shuttle Endeavour's launch Nov. 14 on mission STS-126. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

KSC-08pd0263

NASA Image and Video Library

2008-02-10

KENNEDY SPACE CENTER, FLA. -- The solid rocket booster retrieval ship Freedom Star is temporarily docked at Port Canaveral while the booster it was towing is moved alongside for the remainder of the trip upriver to Cape Canaveral Air Force Station. Freedom Star retrieved the booster after the launch of space shuttle Atlantis' STS-122 mission. The space shuttle's solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship's tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0262

NASA Image and Video Library

2008-02-10

KENNEDY SPACE CENTER, FLA. -- The solid rocket booster retrieval ship Freedom Star is temporarily docked at Port Canaveral while the booster it was towing is moved alongside for the remainder of the trip upriver to Cape Canaveral Air Force Station. Freedom Star retrieved the booster after the launch of space shuttle Atlantis' STS-122 mission. The space shuttle's solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship's tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

VizieR Online Data Catalog: The MIT-Green Bank 5GHz Survey (Bennett+, 1986-91)

NASA Astrophysics Data System (ADS)

Bennett, C. L.; Lawrence, C. R.; Burke, B. F.; Hewitt, J. N.; Mahoney, J.

2003-08-01

The MIT-Green Bank 5GHz survey catalog was produced from four separate surveys with the National Radio Astronomy Observatory (NRAO) 91m transit telescope (Bennett et al., 1986ApJS...61....1B (MG1); Langston et al., 1990ApJS...72..621L (MG2); Griffith et al., 1990ApJS...74..129G (MG3); Griffith et al. 1991ApJS...75..801G (MG4)). The sky coverage of the various surveys is: 00h < RAB < 24h, -00d30'13" < DECB < +19d29'47" for MG1; 04h < RAJ < 21h, +17.0d < DECJ < +39d09' for MG2; 16h30m < RAB < 05h, +17d < DECB < +39d09' for MG3; and 15h30m < RAB < 02h30m, +37.00d < DECB < +50d58'48" for MG4; where RAB and DECB refer to B1950 coordinates, and RAJ and DECJ refer to J2000 coordinates. The catalog contains 20344 sources detected with a signal-to-noise ratio greater than 5 and 3836 possible detections (MG1) with a signal-to-noise ratio less than 5. Spectral indices are computed for MG1 sources also identified in the Texas 365MHz survey (Douglas et al. 1980), and for MG1-MG4 sources also identified in the NRAO 1400MHz Survey (Condon and Broderick 1985). (1 data file).

VizieR Online Data Catalog: The MIT-Green Bank 5GHz Survey (Bennett+, 1986-91)

NASA Astrophysics Data System (ADS)

Bennett, C. L.; Lawrence, C. R.; Burke, B. F.; Hewitt, J. N.; Mahoney, J.

1999-04-01

The MIT-Green Bank 5 GHz survey catalog was produced from four separate surveys with the National Radio Astronomy Observatory (NRAO) 91m transit telescope (Bennett et al., 1986ApJS...61....1B (MG1); Langston et al., 1990ApJS...72..621L (MG2); Griffith et al., 1990ApJS...74..129G (MG3); Griffith et al. 1991ApJS...75..801G (MG4)). The sky coverage of the various surveys is: 00h < RAB < 24h, -00d30'13" < DECB < +19d29'47" for MG1; 04h < RAJ < 21h, +17.0d < DECJ < +39d09' for MG2; 16h30m < RAB < 05h, +17d < DECB < +39d09' for MG3; and 15h30m < RAB < 02h30m, +37.00d < DECB < +50d58'48" for MG4; where RAB and DECB refer to B1950 coordinates, and RAJ and DECJ refer to J2000 coordinates. The catalog contains 20344 sources detected with a signal-to-noise ratio greater than 5 and 3836 possible detections (MG1) with a signal-to-noise ratio less than 5. Spectral indices are computed for MG1 sources also identified in the Texas 365 MHz survey (Douglas et al. 1980), and for MG1-MG4 sources also identified in the NRAO 1400 MHz Survey (Condon and Broderick 1985). (1 data file).

Long-term efficacy of Internet-based cognitive behavior therapy for obsessive-compulsive disorder with or without booster: a randomized controlled trial.

PubMed

Andersson, E; Steneby, S; Karlsson, K; Ljótsson, B; Hedman, E; Enander, J; Kaldo, V; Andersson, G; Lindefors, N; Rück, C

2014-10-01

As relapse after completed cognitive behavior therapy (CBT) for obsessive-compulsive disorder (OCD) is common, many treatment protocols include booster programs to improve the long-term effects. However, the effects of booster programs are not well studied. In this study, we investigated the long-term efficacy of Internet-based CBT (ICBT) with therapist support for OCD with or without an Internet-based booster program. A total of 101 participants were included in the long-term follow-up analysis of ICBT. Of these, 93 were randomized to a booster program or no booster program. Outcome assessments were collected at 4, 7, 12 and 24 months after receiving ICBT. The entire sample had sustained long-term effects from pre-treatment to all follow-up assessments, with large within-group effect sizes (Cohen's d = 1.58-2.09). The booster group had a significant mean reduction in OCD symptoms compared to the control condition from booster baseline (4 months) to 7 months, but not at 12 or 24 months. Participants in the booster group improved significantly in terms of general functioning at 7, 12 and 24 months, and had fewer relapses. Kaplan-Meier analysis also indicated a significantly slower relapse rate in the booster group. The results suggest that ICBT has sustained long-term effects and that adding an Internet-based booster program can further improve long-term outcome and prevent relapse for some OCD patients.

Design of the transfer line from booster to storage ring at 3 GeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayar, C., E-mail: cafer.bayar@cern.ch; Ciftci, A. K., E-mail: abbas.kenan.ciftci@cern.ch

The Synchrotron Booster Ring accelerates the e-beam up to 3 GeV and particles are transported from booster to storage ring by transfer line. In this study, two options are considered, the first one is a long booster which shares the same tunnel with storage ring and the second one is a compact booster. As a result, two transfer line are designed based on booster options. The optical design is constrained by the e-beam Twiss parameters entering and leaving the transfer line. Twiss parameters in the extraction point of booster are used for the entrance of transfer line and are matchedmore » in the exit of transfer line to the injection point of the storage ring.« less

Exercise, manual therapy, and use of booster sessions in physical therapy for knee osteoarthritis: a multi-center, factorial randomized clinical trial.

PubMed

Fitzgerald, G K; Fritz, J M; Childs, J D; Brennan, G P; Talisa, V; Gil, A B; Neilson, B D; Abbott, J H

2016-08-01

(1) Do treatment effects differ between participants receiving manual therapy (MT) with exercise compared to subjects who don't, (2) are treatment effects sustained better when participants receive booster sessions compared to those who don't over a one year period in subjects with knee osteoarthritis (KOA)? Multi-center, 2 × 2 factorial randomized clinical trial. 300 participants with knee OA were randomized to four groups: exercise-no boosters (Ex), exercise-with boosters (Ex+B), manual therapy+exercise-no boosters (MT+Ex), manual therapy+exercise-with boosters (MT+Ex+B). The primary outcome was the Western Ontario and McMaster osteoarthritis index (WOMAC) at 1 year. Secondary outcomes included knee pain, physical performance tests, and proportions of participants meeting treatment responder criteria. There were no differences between groups on the WOMAC at 1 year or on any performance-based measures. Secondary analyses indicated a) better scores on the WOMAC and greater odds of being a treatment responder at 9 weeks for participants receiving MT, b) greater odds of being a treatment responder at 1 year for participants receiving boosters. Exploratory interaction analysis suggested knee pain decreases for participants receiving boosters and increases for participants not receiving boosters from 9 weeks to 1 year. MT or use of boosters with exercise did not result in additive improvement in the primary outcome at 1 year. Secondary outcomes suggest MT may have some short term benefit, and booster sessions may improve responder status and knee pain at 1 year. However, the role of booster sessions remains unclear in sustaining treatment effects and warrants further study. gov (NCT01314183). Copyright © 2016 Osteoarthritis Research Society International. All rights reserved.

46 CFR 108.421 - Location of fire pumps and associated equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Location of fire pumps and associated equipment. 108.421... pumps and associated equipment. Each fire pump required by § 108.415, and the source of power, controls, sea connections for the fire pump, and booster pumps, if installed, must be installed in locations...

Expendable second stage reusable space shuttle booster. Volume 2: Technical summary. Book 3: Booster vehicle modifications and ground systems definition

NASA Technical Reports Server (NTRS)

1972-01-01

A definition of the expendable second stage and space shuttle booster separation system is presented. Modifications required on the reusable booster for expendable second stage/payload flight and the ground systems needed to operate the expendable second stage in conjuction with the space shuttle booster are described. The safety, reliability, and quality assurance program is explained. Launch complex operations and services are analyzed.

Maintaining the potential of a psycho-educational program: efficacy of a booster session after an intervention offered family caregivers at disclosure of a relative's dementia diagnosis.

PubMed

Ducharme, Francine; Lachance, Lise; Lévesque, Louise; Zarit, Steven Howard; Kergoat, Marie-Jeanne

2015-01-01

Booster sessions as a means of maintaining the benefits of psycho-educational programs have received little attention in caregiving research. Caregivers were offered a booster session following participation in a program entitled Learning to Become a Family Caregiver (LBFC) intended to facilitate transition to the caregiver role after diagnostic disclosure of dementia in a relative. The 90-minute booster session served to review program content and afforded the opportunity to discuss and practice learned skills. This study sought to test the efficacy of the booster session in maintaining or recovering program effects at six months post-program. Participants in the program were randomly assigned to a group that received the booster session (n = 31) or a group that did not (n = 29). A third control group was also formed, which continued to receive only the usual care provided in memory clinics. Eligible participants - French-speaking primary caregivers of a relative diagnosed with Alzheimer's in the past nine months - were recruited in memory clinics in Quebec (Canada). Participants were blindly assessed before randomization and six months after the booster session on outcomes associated with a healthy role transition. Prediction analyses revealed one significant positive effect of the booster session: emergence of preparedness to provide care. Moreover, with or without the booster session, the program continued to have a positive effect on psychological distress and contributed to the emergence of self-efficacy in dealing with caregiving situations. The booster session had no significant effect on knowledge of services, planning for future care needs, use of reframing as a coping strategy, perceived informal support, and family conflicts. The limited effect observed is discussed in terms of the booster session's content and intensity. Recommendations are made for designing future research on the effect of booster sessions, including the importance of including a placebo booster group.

47 CFR 22.527 - Signal boosters.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 2 2011-10-01 2011-10-01 false Signal boosters. 22.527 Section 22.527... Paging and Radiotelephone Service § 22.527 Signal boosters. Licensees may install and operate signal... additional transmitters for existing systems. Licensees must not allow any signal booster that they operate...

47 CFR 22.527 - Signal boosters.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Signal boosters. 22.527 Section 22.527... Paging and Radiotelephone Service § 22.527 Signal boosters. Licensees may install and operate signal... additional transmitters for existing systems. Licensees must not allow any signal booster that they operate...

47 CFR Alphabetical Index - Part 74

Code of Federal Regulations, 2014 CFR

2014-10-01

... FM Broadcast Booster Stations FM translator and booster station information available on the Internet..., Directional (Aural STL/Relays) 74.536 Antenna location— LPTV/TV Translator 74.737 FM Translators/Boosters 74....902 FM Translators/Boosters 74.1202 Authorization of equipment— Aural Auxiliary 74.550 Remote Pickup...

47 CFR Alphabetical Index - Part 74

Code of Federal Regulations, 2013 CFR

2013-10-01

... FM Broadcast Booster Stations FM translator and booster station information available on the Internet..., Directional (Aural STL/Relays) 74.536 Antenna location— LPTV/TV Translator 74.737 FM Translators/Boosters 74....902 FM Translators/Boosters 74.1202 Authorization of equipment— Aural Auxiliary 74.550 Remote Pickup...

47 CFR 24.9 - Operation of certificated signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false Operation of certificated signal boosters. 24.9... PERSONAL COMMUNICATIONS SERVICES General Information § 24.9 Operation of certificated signal boosters. Individuals and non-individuals may operate certificated Consumer Signal Boosters on frequencies regulated...

47 CFR 24.9 - Operation of certificated signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false Operation of certificated signal boosters. 24.9... PERSONAL COMMUNICATIONS SERVICES General Information § 24.9 Operation of certificated signal boosters. Individuals and non-individuals may operate certificated Consumer Signal Boosters on frequencies regulated...

47 CFR Alphabetical Index - Part 74

Code of Federal Regulations, 2012 CFR

2012-10-01

... FM Broadcast Booster Stations FM translator and booster station information available on the Internet..., Directional (Aural STL/Relays) 74.536 Antenna location— LPTV/TV Translator 74.737 FM Translators/Boosters 74....902 FM Translators/Boosters 74.1202 Authorization of equipment— Aural Auxiliary 74.550 Remote Pickup...

75 FR 6823 - Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-11

...-AP73 Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR... Review (NSR): Reconsideration of Fugitive Emissions'' (``Fugitive Emissions Rule''). The Fugitive... whether a physical or operation change results in a major modification only for sources in industries that...

Do parental decision-making patterns predict compliance with use of child booster seats?

PubMed

Shimony-Kanat, Sarit; Gofin, Rosa; Kienski Woloski Wruble, Anna C; Mann, Leon

2018-03-01

Booster seat use for 4-9 year olds remains the lowest of all age groups in many countries. The objective of this study is to examine whether parents' decision-making patterns, as measured by the Melbourne Decision Making Questionnaire, relate to car booster seat use. Israeli parents of 4-7 years old children (n = 398) answered a questionnaire about car safety and decision-making habits. Ninety per cent of parents reported having a booster seat; 70.5% reported consistent booster seat use in general and on short drives during the last month (booster seat use compliance index). Greater compliance index was positively related to a vigilant decision-making pattern, passenger compliance with rear seat belts and families with fewer children. Lower booster seat use compliance index was associated with buck-passing decision-making pattern. Health professionals and policy-makers should take into account parents' habitual decision-making patterns when designing interventions for car booster seat compliance.

The Use of Amino Sugars by Bacillus subtilis: Presence of a Unique Operon for the Catabolism of Glucosamine

PubMed Central

Gaugué, Isabelle; Oberto, Jacques; Putzer, Harald; Plumbridge, Jacqueline

2013-01-01

B. subtilis grows more rapidly using the amino sugar glucosamine as carbon source, than with N-acetylglucosamine. Genes for the transport and metabolism of N-acetylglucosamine (nagP and nagAB) are found in all the sequenced Bacilli (except Anoxybacillus flavithermus). In B. subtilis there is an additional operon (gamAP) encoding second copies of genes for the transport and catabolism of glucosamine. We have developed a method to make multiple deletion mutations in B. subtilis employing an excisable spectinomycin resistance cassette. Using this method we have analysed the contribution of the different genes of the nag and gam operons for their role in utilization of glucosamine and N-acetylglucosamine. Faster growth on glucosamine is due to the presence of the gamAP operon, which is strongly induced by glucosamine. Although the gamA and nagB genes encode isozymes of GlcN6P deaminase, catabolism of N-acetylglucosamine relies mostly upon the gamA gene product. The genes for use of N-acetylglucosamine, nagAB and nagP, are repressed by YvoA (NagR), a GntR family regulator, whose gene is part of the nagAB yvoA(nagR) operon. The gamAP operon is repressed by YbgA, another GntR family repressor, whose gene is expressed divergently from gamAP. The nagAB yvoA synton is found throughout the Bacilli and most firmicutes. On the other hand the ybgA-gamAP synton, which includes the ybgB gene for a small protein of unknown provenance, is only found in B. subtilis (and a few very close relatives). The origin of ybgBA-gamAP grouping is unknown but synteny analysis suggests lateral transfer from an unidentified donor. The presence of gamAP has enabled B. subtilis to efficiently use glucosamine as carbon source. PMID:23667565

System modeling of the Thirty Meter Telescope alignment and phasing system

NASA Astrophysics Data System (ADS)

Dekens, Frank G.; Seo, Byoung-Joon; Troy, Mitchell

2014-08-01

We have developed a system model using the System Modeling Language (SysML) for the Alignment and Phasing System (APS) on the Thirty Meter Telescope (TMT). APS is a Shack-Hartmann wave-front sensor that will be used to measure the alignment and phasing of the primary mirror segments, and the alignment of the secondary and tertiary mirrors. The APS system model contains the ow-down of the Level 1 TMT requirements to APS (Level 2) requirements, and from there to the APS sub-systems (Level 3) requirements. The model also contains the operating modes and scenarios for various activities, such as maintenance alignment, post-segment exchange alignment, and calibration activities. The requirements ow-down is captured in SysML requirements diagrams, and we describe the process of maintaining the DOORS database as the single-source-of-truth for requirements, while using the SysML model to capture the logic and notes associated with the ow-down. We also use the system model to capture any needed communications from APS to other TMT systems, and between the APS sub-systems. The operations are modeled using SysML activity diagrams, and will be used to specify the APS interface documents. The modeling tool can simulate the top level activities to produce sequence diagrams, which contain all the communications between the system and subsystem needed for that activity. By adding time estimates for the lowest level APS activities, a robust estimate for the total time on-sky that APS requires to align and phase the telescope can be obtained. This estimate will be used to verify that the time APS requires on-sky meets the Level 1 TMT requirements.

Effects of booster interventions on factory workers' use of hearing protection.

PubMed

Lusk, Sally L; Eakin, Brenda L; Kazanis, Anamaria S; McCullagh, Marjorie C

2004-01-01

The provision of reinforcements or boosters to interventions is seen as a logical approach to enhancing or maintaining desired behavior. Empirical studies, however, have not confirmed the effectiveness of boosters nor assessed the optimum number of boosters or the timing for their delivery. This randomized controlled trial contrasted the effect of four booster conditions (a). 30 days; (b). 90 days; (c). 30 and at 90 days; and (d). no boosters of the intervention to increase the use of hearing protection devices (HPDs). A total of 1325 factory workers completed a computerized questionnaire and were randomly assigned to one of three computer-based (tailored, nontailored predictor-based, or control) multimedia interventions designed to increase the use of hearing protection devices. After the intervention, colorful boosters specific to the type of training received were mailed to workers' homes. Posttest measures of use were administered at the time of their next annual audiogram 6 to 18 months after the intervention. RESULTS Repeated measures of analysis of variance (ANOVA) showed a significant main effect for the booster (after 30 days) in the group that received tailored training (F[3442] = 2.722; p =.04). However, in the assessment of the interaction between time (pretest and posttest) and boosters (four groups), the ANOVA did not find significant differences in hearing protection device use for any of the training groups. To assess for significant differences between groups, post hoc comparisons were conducted at the pretest and posttest for the total sample and for the subsample of workers who reported using hearing protection devices less than 100% of the time needed. Sheffé contrasts by intervention group, gender, ethnicity, and hearing ability found no significant changes in the mean use of hearing protection devices for the booster groups. Although the provision of boosters represented a considerable commitment of resources, their use was not effective in this study. However, it would be premature to eliminate boosters of interventions. Further study is needed to explore the effects of different booster types for increasing the use of hearing protection devices, and to assess carefully the effects of boosters on other health behaviors in studies with controlled designs.

Aerodynamic characteristics of a 142-inch diameter solid rocket booster, configuration 139 (SA2FA/SA2FB)

NASA Technical Reports Server (NTRS)

Radford, W. D.; Johnson, J. D.

1974-01-01

Tests of a 2.112 percent scale model of the space shuttle solid rocket booster model were conducted in a transonic pressure tunnel. Tests were conducted at Mach numbers ranging from 0.4 to 1.2, angles of attack from minus one degree to plus 181 degrees, and Reynolds numbers from 0.6 million to 6.1 million per foot. The model configurations investigated were as follows: (1) solid rocket booster without external protuberances, (2) solid rocket booster with an electrical tunnel and a solid rocket booster/external tank thrust attachment structure, and (3) solid rocket booster with two body strakes.

Hypersonic aerothermal characteristics of a manned low finenes ratio shuttle booster

NASA Technical Reports Server (NTRS)

Bernot, P. T.; Throckmorton, D. A.

1972-01-01

An investigation of a winged booster model having canards and an ascent configuration comprised of the booster mounted in tandem with an orbiter model has been conducted at Mach 10.2 in the continuous flow hypersonic tunnel. Longitudinal and lateral directional force characteristics were obtained over angle of attack ranges of -12 deg to 60 deg for the booster and -11 deg to 11 deg for the ascent configuration. Interference heating effects on the booster using the phase-change coating technique were determined at 0 deg angle of attack. Some oil flow photographs of the isolated booster and orbiter and ascent configuration are also presented.

Analysis of the staging maneuver and booster glideback guidance for a two-stage, winged, fully reusable launch vehicle. M.S. Thesis - George Washington Univ.

NASA Technical Reports Server (NTRS)

Naftel, J. Christopher; Powell, Richard W.

1993-01-01

One of the promising launch concepts that could replace the current space shuttle launch system is a two-stage, winged, vertical-takeoff, fully reusable launch vehicle. During the boost phase of ascent, the booster provides propellant for the orbiter engines through a cross-feed system. When the vehicle reaches a Mach number of 3, the booster propellants are depleted and the booster is staged and glides unpowered to a horizontal landing at a launch site runway. Two major design issues for this class of vehicle are the staging maneuver and the booster glideback. For the staging maneuver analysis, a technique was developed that provides for a successful separation of the booster from the orbiter over a wide range of staging angles of attack. A longitudinal flight control system was developed for control of the booster during the staging maneuver. For the booster glide back analysis, a guidance algorithm was developed that successfully guides the booster from the completion of the staging maneuver to a launch site runway while encountering many off-nominal atmospheric, aerodynamic, and staging conditions.

Theoretical Analysis and Bench Tests of a Control-Surface Booster Employing a Variable Displacement Hydraulic Pump

NASA Technical Reports Server (NTRS)

Mathews, Charles W.; Kleckner, Harold F.

1947-01-01

The NACA is conducting a general investigation of servo-mechanisms for use in powering aircraft control surfaces. This paper presents a theoretical analysis and the results of bench tests of a control-booster system which employs a variable displacement hydraulic pump. The booster is intended for use in a flight investigation to determine the effects of various booster parameters on the handling qualities of airplanes. Such a flight investigation would aid in formulating specific requirements concerning the design of control boosters in general. Results of the theoretical analysis and the bench tests indicate that the subject booster is representative of types which show promise of satisfactory performance. The bench tests showed that the following desirable features were inherent in this booster system: (1) No lost motion or play in any part of the system; (2) no detectable lag between motion of the contra1 stick and control surface; and (3) Good agreement between control displacements and stick-force variations with no hysteresis in the stick-force characteristics. The final design configuration of this booster system showed no tendency to oscillate, overshoot, or have other undesirable transient characteristics common to boosters.

KSC-06pd1492

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star tows a spent solid rocket booster toward Port Canaveral. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1497

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star heads up the Banana River to Cape Canaveral Air Force Station with a spent solid rocket booster alongside. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1491

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star tows a spent solid rocket booster back to Port Canaveral. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-08pd0258

NASA Image and Video Library

2008-02-10

KENNEDY SPACE CENTER, FLA. -- The solid rocket booster retrieval ship Freedom Star tows one of the boosters retrieved after the launch of space shuttle Atlantis' STS-122 mission. The space shuttle's solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship's tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0260

NASA Image and Video Library

2008-02-10

KENNEDY SPACE CENTER, FLA. -- The solid rocket booster retrieval ship Freedom Star tows one of the boosters, retrieved after the launch of space shuttle Atlantis' STS-122 mission, toward Port Canaveral. The space shuttle's solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship's tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0259

NASA Image and Video Library

2008-02-10

KENNEDY SPACE CENTER, FLA. -- Spectators watch as the solid rocket booster retrieval ship Freedom Star tows one of the boosters, retrieved after the launch of space shuttle Atlantis' STS-122 mission, toward Port Canaveral. The space shuttle's solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship's tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd3735

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, the straddle crane lowers a spent solid rocket booster onto a transporter. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The booster is from space shuttle Endeavour, which launched Nov. 14 on the STS-126 mission. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

KSC-08pd3738

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – At Hangar AF at Cape Canaveral Air Force Station in Florida, two spent solid rocket boosters move into the washing bay for a cleaning and rinsing. The boosters are from space shuttle Endeavour, which launched Nov. 14 on the STS-126 mission. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

KSC-08pd0739

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, tows a solid rocket booster alongside, heading for Hangar AF at Cape Canaveral Air Force Station. Barely visible in the background at right is the Vehicle Assembly Building at NASA's Kennedy Space Center. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0261

NASA Image and Video Library

2008-02-10

KENNEDY SPACE CENTER, FLA. -- The solid rocket booster retrieval ship Freedom Star tows toward Port Canaveral one of the boosters, retrieved after the launch of space shuttle Atlantis' STS-122 mission, toward Port Canaveral. The space shuttle's solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship's tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

Randomized, Open-Label Study of the Impact of Age on Booster Responses to the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine in Children in India

PubMed Central

Chatterjee, Sukanta; Chhatwal, Jugesh; Simon, Anna; Ravula, Sudheer; Francois, Nancy; Mehta, Shailesh; Strezova, Ana; Borys, Dorota

2014-01-01

In this phase III, open-label, multicenter, and descriptive study in India, children primed with 3 doses (at ages 6, 10, and 14 weeks) of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) were randomized (1:1) to receive a booster dose at 9 to 12 (early booster) or 15 to 18 months old (late booster) in order to evaluate impact of age at booster. We also evaluated a 2-dose catch-up vaccination plus an experimental booster dose in unprimed children age 12 to 18 months. The early booster, late booster, and catch-up vaccinations were administered to 74, 95, and 87 children, respectively; 66, 71, and 81 children, respectively, were included in the immunogenicity according-to-protocol cohort. One month postbooster, for each PHiD-CV serotype, ≥95.2% (early booster) and ≥93.8% (late booster) of the children had antibody concentrations of ≥0.2 μg/ml; ≥96.7% and ≥93.0%, respectively, had opsonophagocytic activity (OPA) titers of ≥8. The postbooster antibody geometric mean concentrations (GMCs) were in similar ranges for early and late boosters; the OPA titers appeared to be lower for most PHiD-CV serotypes (except 6B and 19F) after the early booster. After dose 2 and postbooster, for each PHiD-CV serotype, ≥88.6% and ≥96.3%, respectively, of the catch-up immunogenicity according-to-protocol cohort had antibody concentrations of ≥0.2 μg/ml; ≥71.4% and ≥90.6%, respectively, had OPA titers of ≥8. At least 1 serious adverse event was reported by 2 children in the early booster (skin infection and gastroenteritis) and 1 child in the catch-up group (febrile convulsion and urinary tract infection); all were resolved, and none were considered by the investigators to be vaccine related. PHiD-CV induced robust immune responses regardless of age at booster. Booster vaccination following 2 catch-up doses induced robust immune responses indicative of effective priming and immunological memory. (These studies have been registered at www.clinicaltrials.gov under registration no. NCT01030822 and NCT00814710; a protocol summary is available at www.gsk-clinicalstudyregister.com [study ID 112909]). PMID:25008901

NASA's Space Launch System Advanced Booster Development

NASA Technical Reports Server (NTRS)

Robinson, Kimberly F.; Crumbly, Christopher M.; May, Todd A.

2014-01-01

The National Aeronautics and Space Administration's (NASA's) Space Launch System (SLS) Program, managed at the Marshall Space Flight Center, is making progress toward delivering a new capability for human space flight and scientific missions beyond Earth orbit. NASA is executing this development within flat budgetary guidelines by using existing engines assets and heritage technology to ready an initial 70 metric ton (t) lift capability for launch in 2017, and then employing a block upgrade approach to evolve a 130-t capability after 2021. A key component of the SLS acquisition plan is a three-phased approach for the first-stage boosters. The first phase is to expedite the 70-t configuration by completing development of the Space Shuttle heritage 5-segment solid rocket boosters (SRBs) for the initial flights of SLS. Since no existing boosters can meet the performance requirements for the 130-t class SLS, the next phases of the strategy focus on the eventual development of advanced boosters with an expected thrust class potentially double the current 5-segment solid rocket booster capability of 3.88 million pounds of thrust each. The second phase in the booster acquisition plan is the Advanced Booster Engineering Demonstration and/or Risk Reduction (ABEDRR) effort, for which contracts were awarded beginning in 2012 after a full and open competition, with a stated intent to reduce risks leading to an affordable advanced booster. NASA has awarded ABEDRR contracts to four industry teams, which are looking into new options for liquid-fuel booster engines, solid-fuel-motor propellants, and composite booster structures. Demonstrations and/or risk reduction efforts were required to be related to a proposed booster concept directly applicable to fielding an advanced booster. This paper will discuss the status of this acquisition strategy and its results toward readying both the 70 t and 130 t configurations of SLS. The third and final phase will be a full and open competition for Design, Development, Test, and Evaluation (DDT&E) of the advanced boosters. These new boosters will enable the flexible path approach to deep space exploration, opening up vast opportunities for human missions to near-Earth asteroids and Mars. This evolved capability will offer large volume for science missions and payloads, will be modular and flexible, and will be right-sized for mission requirements.

47 CFR 22.9 - Operation of certificated signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false Operation of certificated signal boosters. 22.9... PUBLIC MOBILE SERVICES Scope and Authority § 22.9 Operation of certificated signal boosters. Individuals and non-individuals may operate certificated Consumer Signal Boosters on frequencies regulated under...

47 CFR 22.9 - Operation of certificated signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false Operation of certificated signal boosters. 22.9... PUBLIC MOBILE SERVICES Scope and Authority § 22.9 Operation of certificated signal boosters. Individuals and non-individuals may operate certificated Consumer Signal Boosters on frequencies regulated under...

VizieR Online Data Catalog: UV spectra of classical T Tauri stars (France+, 2014)

NASA Astrophysics Data System (ADS)

France, K.; Schindhelm, E.; Bergin, E. A.; Roueff, E.; Abgrall, H.

2017-06-01

We present 16 objects from the larger GTO + DAO T Tauri star samples described by Ardila et al. (2013ApJS..207....1A; focusing on the hot gas emission lines) and France et al. (2012, J/ApJ/756/171; focusing on the molecular circumstellar environment). Eleven of the 16 sources were observed as part of the DAO of Tau guest observing program (PID 11616; PI: G. Herczeg), four were part of the COS Guaranteed Time Observing program on protoplanetary disks (PIDs 11533 and 12036; PI: J. Green), and we have included archival STIS observations of the well-studied CTTS TW Hya (Herczeg et al. 2002ApJ...572..310H, 2004ApJ...607..369H), obtained through StarCAT (Ayres 2010, J/ApJS/187/149). The targets were selected by the availability of reconstructed Lyα spectra, as this emission line is a critical component to the intrinsic CTTS UV radiation field (Schindhelm et al. 2012ApJ...756L..23S) and has not been uniformly included in recent studies of the CTTS radiation field (e.g., Ingleby et al. 2011AJ....141..127I; Yang et al. 2012, J/ApJ/744/121). Most of the targets were observed with the medium-resolution FUV modes of COS (G130M and G160M; Green et al. 2012ApJ...744...60G). (2 data files).

Closeup view of the Solid Rocket Booster Frustum and Nose ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Close-up view of the Solid Rocket Booster Frustum and Nose Cap assembly undergoing preparations and close-out procedures in the Solid Rocket Booster Assembly and Refurbishment Facility at Kennedy Space Center. The Nose Cap contains the Pilot and Drogue Chutes and the Frustum contains the three Main Parachutes, Altitude Switches and forward booster Separation Motors. - Space Transportation System, Solid Rocket Boosters, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

KSC-2009-2142

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, the solid rocket booster is lifted out of the water by the straddle crane. The booster, used during space shuttle Discovery's launch from NASA's Kennedy Space Center in Florida March 15 on mission STS-119, will be placed on a transporter. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-2009-2143

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, the straddle crane lowers a solid rocket booster onto a transporter. The booster was used during space shuttle Discovery's launch from NASA's Kennedy Space Center in Florida March 15 on mission STS-119. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-2009-2140

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, the frustum of a solid rocket booster is moved onto a transporter. The booster was used during space shuttle Discovery's launch on mission STS-119 from NASA's Kennedy Space Center in Florida March 15. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd3733

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, workers move the spent solid rocket booster to an area beneath the straddle crane that will lift it out of the water. The booster is from space shuttle Endeavour, which launched Nov. 14 on the STS-126 mission. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The spent rocket was recovered by NASA's Solid Rocket Booster Retrieval Ship Freedom Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

KSC-08pd3734

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, the straddle crane lifts a spent solid rocket booster to allow saltwater contamination to be rinsed off. The booster is from space shuttle Endeavour, which launched Nov. 14 on the STS-126 mission. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The spent rocket was recovered by NASA's Solid Rocket Booster Retrieval Ship Freedom Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

Orbital Payload Reductions Resulting from Booster and Trajectory Modifications for Recovery of a Large Rocket Booster

NASA Technical Reports Server (NTRS)

Levin, Alan D.; Hopkins, Edward J.

1961-01-01

An analysis was made to determine the reduction in payload for a 300 nautical mile orbit resulting from the addition of inert weight, representing recovery gear, to the first-stage booster of a three-stage rocket vehicle. The values of added inert weight investigated ranged from 0 to 18 percent of gross weight at lift off. The study also included the effects on the payload in orbit and the distance from the launch site at burnout and at impact caused by variation in the vertical rise time before the programmed tilt. The vertical rise times investigated ranged from 16-7 to 100 percent of booster burning time. For a vertical rise of 16.7 percent of booster burning time it was found that a 50-percent increase in the weight of the empty booster resulted in only a 10-percent reduction of the payload in orbit. For no added booster weight, increasing vertical rise time from 16-7 to 100 percent of booster burning time (so that the spent booster would impact in the launch area) reduced the payload by 37 percent. Increasing the vertical rise time from 16-7 to 50 percent of booster burning time resulted in about a 15-percent reduction in the impact distance, and for vertical rise times greater than 50-percent the impact distance decreased rapidly.

APS deposition facility upgrades and future plans

NASA Astrophysics Data System (ADS)

Conley, Ray; Shi, Bing; Erdmann, Mark; Izzo, Scott; Assoufid, Lahsen; Goetze, Kurt; Mooney, Tim; Lauer, Kenneth

2014-09-01

The Advanced Photon Source (APS) has recently invested resources to upgrade or replace aging deposition systems with modern equipment. Of the three existing deposition systems, one will receive an upgrade, while two are being replaced. A design which adds a three-substrate planetary for the APS rotary deposition system is almost complete. The replacement for the APS large deposition system, dubbed the "Modular Deposition System", has been conceptually designed and is in the procurement process. Eight cathodes will sputter horizontally on mirrors up to 1.5 meters in length. This new instrument is designed to interface with ion-milling instruments and various metrology equipment for ion-beam figuring. A third linear machine, called the APS Profile Coating System, has two cathodes and is designed to accept substrates up to 200mm in length. While this machine is primarily intended for fabrication of figured KB mirrors using the profile-coating technique, it has also been used to produce multilayer monochromators for beamline use.

Magnetic Measurements of Storage Ring Magnets for the APS Upgrade Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doose, C.; Dejus, R.; Jaski, M.

2017-06-01

Extensive prototyping of storage ring magnets is ongoing at the Advanced Photon Source (APS) in support of the APS Multi-Bend Achromat (MBA) upgrade project (APS-U) [1]. As part of the R&D activities four quadrupole magnets with slightly different geometries and pole tip materials, and one sextupole magnet with vanadium permendur (VP) pole tips were designed, built and tested. Magnets were measured individually using a rotating coil and a Hall probe for detailed mapping of the magnetic field. Magnets were then assembled and aligned relative to each other on a steel support plate and concrete plinth using precision machined surfaces tomore » gain experience with the alignment method chosen for the APS-U storage ring magnets. The required alignment of magnets on a common support structure is 30 μm rms. Measurements of magnetic field quality, strength and magnet alignment after subjecting the magnets and assemblies to different tests are presented.« less

47 CFR 73.810 - Third adjacent channel interference.

Code of Federal Regulations, 2014 CFR

2014-10-01

... reception of the input signal of any TV translator, TV booster, FM translator or FM booster station; or (iii... authorized and operating LPFM stations, FM translators and FM booster stations. Interference will be... power FM, FM translator or FM booster station to such affected station and to the Commission. (ii) A...

47 CFR 95.1311 - Repeater operations and signal boosters prohibited.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Repeater operations and signal boosters... § 95.1311 Repeater operations and signal boosters prohibited. MURS stations are prohibited from operating as a repeater station or as a signal booster. This prohibition includes store-and-forward packet...

47 CFR 22.527 - Signal boosters.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 2 2012-10-01 2012-10-01 false Signal boosters. 22.527 Section 22.527... Paging and Radiotelephone Service § 22.527 Signal boosters. Licensees may install and operate signal boosters on channels listed in § 22.531 only in accordance with the provisions of § 22.165 governing...

47 CFR 95.1311 - Repeater operations and signal boosters prohibited.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Repeater operations and signal boosters... § 95.1311 Repeater operations and signal boosters prohibited. MURS stations are prohibited from operating as a repeater station or as a signal booster. This prohibition includes store-and-forward packet...

47 CFR 74.1290 - FM translator and booster station information available on the Internet.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false FM translator and booster station information... DISTRIBUTIONAL SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1290 FM translator and booster station information available on the Internet. The Media Bureau's Audio Division...

47 CFR 74.780 - Broadcast regulations applicable to translators, low power, and booster stations.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., low power, and booster stations. 74.780 Section 74.780 Telecommunication FEDERAL COMMUNICATIONS... PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.780 Broadcast regulations applicable to translators, low power, and booster stations. The following rules are applicable to...

47 CFR 22.527 - Signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false Signal boosters. 22.527 Section 22.527... Paging and Radiotelephone Service § 22.527 Signal boosters. Licensees may install and operate signal boosters on channels listed in § 22.531 only in accordance with the provisions of § 22.165 governing...

47 CFR 74.780 - Broadcast regulations applicable to translators, low power, and booster stations.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., low power, and booster stations. 74.780 Section 74.780 Telecommunication FEDERAL COMMUNICATIONS... PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.780 Broadcast regulations applicable to translators, low power, and booster stations. The following rules are applicable to...

47 CFR 95.1311 - Repeater operations and signal boosters prohibited.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Repeater operations and signal boosters... § 95.1311 Repeater operations and signal boosters prohibited. MURS stations are prohibited from operating as a repeater station or as a signal booster. This prohibition includes store-and-forward packet...

47 CFR 74.1290 - FM translator and booster station information available on the Internet.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false FM translator and booster station information... DISTRIBUTIONAL SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1290 FM translator and booster station information available on the Internet. The Media Bureau's Audio Division...

47 CFR 74.1290 - FM translator and booster station information available on the Internet.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false FM translator and booster station information... DISTRIBUTIONAL SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1290 FM translator and booster station information available on the Internet. The Media Bureau's Audio Division...

47 CFR 95.1311 - Repeater operations and signal boosters prohibited.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Repeater operations and signal boosters... § 95.1311 Repeater operations and signal boosters prohibited. MURS stations are prohibited from operating as a repeater station or as a signal booster. This prohibition includes store-and-forward packet...

47 CFR 73.810 - Third adjacent channel interference.

Code of Federal Regulations, 2013 CFR

2013-10-01

... reception of the input signal of any TV translator, TV booster, FM translator or FM booster station; or (iii... authorized and operating LPFM stations, FM translators and FM booster stations. Interference will be... power FM, FM translator or FM booster station to such affected station and to the Commission. (ii) A...

47 CFR 22.527 - Signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false Signal boosters. 22.527 Section 22.527... Paging and Radiotelephone Service § 22.527 Signal boosters. Licensees may install and operate signal boosters on channels listed in § 22.531 only in accordance with the provisions of § 22.165 governing...

47 CFR 95.1311 - Repeater operations and signal boosters prohibited.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Repeater operations and signal boosters... § 95.1311 Repeater operations and signal boosters prohibited. MURS stations are prohibited from operating as a repeater station or as a signal booster. This prohibition includes store-and-forward packet...

47 CFR 74.780 - Broadcast regulations applicable to translators, low power, and booster stations.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., low power, and booster stations. 74.780 Section 74.780 Telecommunication FEDERAL COMMUNICATIONS... PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.780 Broadcast regulations applicable to translators, low power, and booster stations. The following rules are applicable to...

47 CFR 101.151 - Use of signal boosters.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., or portable station(s). The booster will fill in only weak signal areas and cannot extend the system... 47 Telecommunication 5 2012-10-01 2012-10-01 false Use of signal boosters. 101.151 Section 101.151... SERVICES Technical Standards § 101.151 Use of signal boosters. Private operational-fixed licensees...

47 CFR 101.151 - Use of signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., or portable station(s). The booster will fill in only weak signal areas and cannot extend the system... 47 Telecommunication 5 2013-10-01 2013-10-01 false Use of signal boosters. 101.151 Section 101.151... SERVICES Technical Standards § 101.151 Use of signal boosters. Private operational-fixed licensees...

47 CFR 101.151 - Use of signal boosters.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., or portable station(s). The booster will fill in only weak signal areas and cannot extend the system... 47 Telecommunication 5 2010-10-01 2010-10-01 false Use of signal boosters. 101.151 Section 101.151... SERVICES Technical Standards § 101.151 Use of signal boosters. Private operational-fixed licensees...

47 CFR 101.151 - Use of signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., or portable station(s). The booster will fill in only weak signal areas and cannot extend the system... 47 Telecommunication 5 2014-10-01 2014-10-01 false Use of signal boosters. 101.151 Section 101.151... SERVICES Technical Standards § 101.151 Use of signal boosters. Private operational-fixed licensees...

47 CFR 101.151 - Use of signal boosters.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., or portable station(s). The booster will fill in only weak signal areas and cannot extend the system... 47 Telecommunication 5 2011-10-01 2011-10-01 false Use of signal boosters. 101.151 Section 101.151... SERVICES Technical Standards § 101.151 Use of signal boosters. Private operational-fixed licensees...

76 FR 11680 - Digital Low Power Television, Television Translator, and Television Booster Stations and Digital...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

...] Digital Low Power Television, Television Translator, and Television Booster Stations and Digital Class A... Commission's Rules to Establish Rules for Digital Low Power, Television Translator, and Television Booster... Digital Low Power Television Translator, Television Booster Stations, and to Amend Rules for Digital Class...

Magnetic field errors tolerances of Nuclotron booster

NASA Astrophysics Data System (ADS)

Butenko, Andrey; Kazinova, Olha; Kostromin, Sergey; Mikhaylov, Vladimir; Tuzikov, Alexey; Khodzhibagiyan, Hamlet

2018-04-01

Generation of magnetic field in units of booster synchrotron for the NICA project is one of the most important conditions for getting the required parameters and qualitative accelerator operation. Research of linear and nonlinear dynamics of ion beam 197Au31+ in the booster have carried out with MADX program. Analytical estimation of magnetic field errors tolerance and numerical computation of dynamic aperture of booster DFO-magnetic lattice are presented. Closed orbit distortion with random errors of magnetic fields and errors in layout of booster units was evaluated.

Space shuttle phase B extension, volume 2

NASA Technical Reports Server (NTRS)

1971-01-01

Space shuttle systems are defined using a low technology orbiter combined with either an F-1 flyback booster or a pressure-fed booster. The mission and system requirements are given, and orbiter and booster configuration concepts are evaluated. Systems analyses and trades are discussed for LO2-RP propellent, F-1 engine main propulsion system, winged flyback recovery booster and for the pressure-fed, ocean recoverable, refurbishable booster system. Trade studies are also made for aluminum versus titanium orbiter and for crew location and compartment size.

A simple optical system delivering a tunable micrometer pink beam that can compensate for heat-induced deformations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reininger, Ruben; Liu, Zunping; Doumy, Gilles

2015-06-09

The radiation from an undulator reflected from one or more optical elements (usually termed `pink-beam') is used in photon-hungry experiments. The optical elements serve as a high-energy cutoff and for focusing purposes. One of the issues with this configuration is maintaining the focal spot dimension as the energy of the undulator is varied, since this changes the heat load absorbed by the first optical element. Finite-element analyses of the power absorbed by a side water-cooled mirror exposed to the radiation emitted by an undulator at the Advanced Photon Source (APS) and at the APS after the proposed upgrade (APSU) revealsmore » that the mirror deformation is very close to a convex cylinder creating a virtual source closer to the mirror than the undulator source. Here a simple optical system is described based on a Kirkpatrick–Baez pair which keeps the focus size to less than 2 µm (in the APSU case) with a working distance of 350 mm despite the heat-load-induced change in source distance. Detailed ray tracings at several photon energies for both the APS and APSU show that slightly decreasing the angle of incidence on the mirrors corrects the change in the `virtual' position of the source. The system delivers more than 70% of the first undulator harmonic with very low higher-orders contamination for energies between 5 and 10 keV.« less

Hybrid propulsion technology program. Volume 1: Conceptional design package

NASA Technical Reports Server (NTRS)

Jensen, Gordon E.; Holzman, Allen L.; Leisch, Steven O.; Keilbach, Joseph; Parsley, Randy; Humphrey, John

1989-01-01

A concept design study was performed to configure two sizes of hybrid boosters; one which duplicates the advanced shuttle rocket motor vacuum thrust time curve and a smaller, quarter thrust level booster. Two sizes of hybrid boosters were configured for either pump-fed or pressure-fed oxygen feed systems. Performance analyses show improved payload capability relative to a solid propellant booster. Size optimization and fuel safety considerations resulted in a 4.57 m (180 inch) diameter large booster with an inert hydrocarbon fuel. The preferred diameter for the quarter thrust level booster is 2.53 m (96 inches). As part of the design study critical technology issues were identified and a technology acquisition and demonstration plan was formulated.

Performance evaluation of DAAF as a booster material using the onionskin test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morris, John S; Francois, Elizabeth G; Hooks, Daniel E

Initiation of insensitive high explosive (IHE) formulations requires the use of a booster explosive in the initiation train. Booster material selection is crucial, as the initiation must reliably function across some spectrum of physical parameters. The interest in Diaminoazoxyfurazan (DAAF) for this application stems from the fact that it possesses many traits of an IHE but is shock sensitive enough to serve as an explosive booster. A hemispherical wave breakout test, termed the onionskin test, is one of the methods used to evaluate the performance of a booster material. The wave breakout time-position history at the surface of a hemisphericalmore » IHE charge is recorded and the relative uniformity of the breakout can be quantitatively compared between booster materials. A series of onionskin tests were performed to investigate breakout and propagation diaminoazoxyfurazan (DAAF) at low temperatures to evaluate ignition and detonation spreading in comparison to other explosives commonly used in booster applications. Some wave perturbation was observed with the DAAF booster in the onionskin tests presented. The results of these tests will be presented and discussed.« less

Investigation of the McDonnell-Douglas orbiter and booster shuttle models in proximity at Mach numbers 2.0 to 6.0. Volume 7: Proximity data at Mach 4 and 6, interference free and launch vehicle data

NASA Technical Reports Server (NTRS)

Trimmer, L. L.; Love, D. A.; Decker, J. P.; Blackwell, K. L.; Strike, W. T.; Rampy, J. M.

1972-01-01

Aerodynamic data obtained from a space shuttle abort stage separation wind tunnel test are presented. The .00556 scale models of the orbiter and booster configuration were tested in close proximity using dual balances during the time period of April 21 to April 27 1971. Data were obtained for both booster and orbiter over an angle of attack range from -10 to 10 deg for zero degree sideslip angle. The models were tested at several relative incidence angles and separation distances and power conditions. Plug nozzles utilizing air were used to simulate booster and orbiter plumes at various altitudes along a nominal ascent trajectory. Powered conditions were 100, 50, 25 and 0 percent of full power for the orbiter and 100, 50 and 0 percent of full power for the booster. Pitch control effectiveness data were obtained for both booster and orbiter with power on and off. In addition, launch vehicle data with and without booster power were obtained utilizing a single balance in the booster model. Data were also obtained with the booster canard off in close proximity and for the launch configuration.

Promoting booster seat use for young children: A school-based intervention pilot study.

PubMed

Bruce, Beth S; Mundle, Kim; Cramm, Camille F; Williams, Devon P

2017-05-01

Misuse and/or lack of booster seat use are often associated with high rates of injury and death among school-aged children. This pilot study examined the efficacy and the potential effectiveness of a booster seat intervention in the classroom. Two elementary schools participated (randomly assigned as one intervention school and one control school). At the intervention school, a certified car seat specialist and a police officer held an interactive booster seat session. The height and age for each child were recorded. Children received a certificate indicating whether they met the requirements for booster seat use and a postcard with car seat restraint specifications. Children in the control school received a brochure on car seat safety. Pre- and post-intervention self-reports were collected and booster seat use was observed. Observational findings showed a decline in booster seat use at the control school and an increase in use at the intervention school. Self-reports of booster seat use indicated a decline at both schools; however, cell sizes were too small to permit statistical analyses. Anecdotally researchers found the sessions were easy to conduct and were well received by the children and could be easily integrated into programming in schools. Classroom sessions may have the potential to positively influence booster seat use among 6- to 8-year-olds.

KSC-06pd1494

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - At a dock in Port Canaveral, the SRB Retrieval Ship Liberty Star has successfully transferred its tow cargo, a spent solid rocket booster, to a starboard position for the balance of its journey to Cape Canaveral Air Force Station. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1498

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - With the Vehicle Assembly Building in the background, the SRB Retrieval Ship Liberty Star nears Cape Canaveral Air Force Station with a spent solid rocket booster alongside. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1500

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star closes in on the dock at Hangar AF, Cape Canaveral Air Force Station, with a spent solid rocket booster alongside. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1502

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star arrives at the dock at Hangar AF, Cape Canaveral Air Force Station, with a spent solid rocket booster alongside. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1499

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star closes in on the dock at Hangar AF, Cape Canaveral Air Force Station, with a spent solid rocket booster alongside. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1503

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - At the dock at Hangar AF, Cape Canaveral Air Force Station, the SRB Retrieval Ship Liberty Star gets ready to transfer the spent solid rocket booster to a straddle crane that will lift it out of the water. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1493

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - At a dock in Port Canaveral, the SRB Retrieval Ship Liberty Star transfers its tow cargo, a spent solid rocket booster, to a starboard position for the balance of its journey to Cape Canaveral Air Force Station. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1495

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star begins the rest of its journey to Cape Canaveral Air Force Station with a spent solid rocket booster alongside. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1501

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star closes in on the dock at Hangar AF, Cape Canaveral Air Force Station, with a spent solid rocket booster alongside. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1506

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - At the dock at Hangar AF, Cape Canaveral Air Force Station, workers move the spent solid rocket booster underneath the straddle crane that will lift it out of the water. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1496

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - The SRB Retrieval Ship Liberty Star begins the rest of its journey to Cape Canaveral Air Force Station with a spent solid rocket booster alongside. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-08pd3737

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, two spent solid rocket boosters begin moving to the hangar for the safing process. They will be driven through the washing bay for a cleaning and rinsing. The boosters are from space shuttle Endeavour, which launched Nov. 14 on the STS-126 mission. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

KSC-08pd3730

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – NASA's Solid Rocket Booster Retrieval Ship Freedom Star tows along its side one of the spent booster rockets from the space shuttle Endeavour launch Nov. 14 on the STS-126 mission. The ship is returning the spent rocket to Hangar AF at Cape Canaveral Air Force Station in Florida. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

Evaluation of Safe Kids Week 2004: age 4 to 9? It's booster seat time!

PubMed

Howard, A; Beben, N; Rothman, L; Fiissel, D; MacArthur, C

2006-10-01

To assess the effectiveness of a national one week media campaign promoting booster seat use. Pre-test, post-test design based on nationally representative random digit dialing telephone survey, with control for exposure to campaign. Canada. Parents of children aged 4-9 years. During a one week campaign in May 2004, information on booster seat use was distributed via a national media campaign, retail stores, medical clinics, and community events. Information included pamphlets with guidelines for booster seat use, as well as a growth chart (designed by Safe Kids Canada) to assist parents in determining if their child should be using a booster seat. Assessing seat belt fit was described in detail on the growth chart. Knowledge, attitudes, and self-reported behaviors regarding booster seat use. Respondents in the group exposed to the campaign were twice as likely to report using a booster seat with lap and shoulder belt for their child (47%), compared to those in the pre-test (24%) and the unexposed (23%) groups (p<0.001). However, only small differences in general knowledge regarding booster seat use were found between the groups. A one week national media campaign substantially increased self-reported use of booster seats. Parents did not remember details of the campaign content, but did remember implications for their own child.

Carpooling and booster seats: a national survey of parents.

PubMed

Macy, Michelle L; Clark, Sarah J; Freed, Gary L; Butchart, Amy T; Singer, Dianne C; Sasson, Comilla; Meurer, William J; Davis, Matthew M

2012-02-01

Booster seat use among school-aged children has been consistently lower than national goals. In this study, we sought to explore associations between parental experiences with booster seats and carpooling. We conducted a cross-sectional Web-based survey of a nationally representative panel of US parents in January 2010. As part of a larger survey, parents of 4- to 8-year-old children responded to 12 questions related to booster seats and carpooling. Of 1612 parents responding to the full survey (response rate = 71%), 706 had a 4- to 8-year-old child and 681 met inclusion rules. Most parents (76%) reported their child used a safety seat when riding in the family car. Of children reported to use seat belts, 74% did so in accordance with their state law. Parent report of child safety seat use was associated with younger child age and with the presence of state booster seat laws. Sixty-four percent of parents carpool. Among parents who carpool and whose children use a child safety seat: 79% indicated they would always ask another driver to use a booster seat for their child and 55% reported they always have their child use their booster seat when driving friends who do not have boosters. Carpooling is a common driving situation during which booster seat use is inconsistent. Social norms and self-efficacy are associated with booster seat use. Clinicians who care for children should increase efforts to convey the importance of using the size-appropriate restraint for every child on every trip.

Cellular and humoral immune responses to a tetanus toxoid booster in perinatally HIV-1-infected children and adolescents receiving highly active antiretroviral therapy (HAART).

PubMed

Ching, Natascha; Deville, Jaime G; Nielsen, Karin A; Ank, Bonnie; Wei, Lian S; Sim, Myung Shin; Wolinsky, Steven M; Bryson, Yvonne J

2007-01-01

Human immunodeficiency virus type 1 (HIV-1) infected children treated with highly active antiretroviral therapy (HAART) may develop a significant reduction of plasma viremia associated with an increase in CD4+ T-cell counts. Functional capacity of this reconstituted immune system in response to recall antigens is important to maintain protective immunity to vaccine-preventable diseases. We therefore determined cellular and humoral immune responses to tetanus toxoid (TT) booster in perinatally HIV-1-infected children and adolescents receiving HAART. Immune responses were prospectively evaluated pre- and post-tetanus booster using lymphocyte proliferation assay (LPA) stimulation index (SI > or = 3.0) and tetanus antibody (TAb > or = 0.15) in 15 patients. The median interval from primary tetanus immunization series was 6 years (range 2-12 years). We compared patients by their virological response to HAART (complete responders, CR, n=7; incomplete responders, ICR, n=8). There were no significant differences in median age 12.6 years (CR: 12.9; ICR: 10.6) or median CD4 T-cell pre-booster (CR: 35%/819; ICR: 26%/429) between groups. Tetanus LPA responses were observed in one patient prior to booster and in seven patients post-booster. In contrast, 38% of patients had protective TAb pre-booster, but 92% developed protective TAb post-booster. All of the CR and 5/6 ICR patients developed protective TAb. HIV-1-infected children and adolescents had modest LPA responses to tetanus following booster, similar to HIV-1-infected adults. However, the majority of patients developed protective TAb levels after booster and maintained the response. Shorter intervals may need to be considered for TT immunization boosters in HIV-1-infected pediatric patients, as only 38% had protective TAb at baseline.

Five year follow-up after a first booster vaccination against tick-borne encephalitis following different primary vaccination schedules demonstrates long-term antibody persistence and safety.

PubMed

Beran, Jiří; Xie, Fang; Zent, Olaf

2014-07-23

Long-term vaccination programs are recommended for individuals living in regions endemic for tick-borne encephalitis (TBE). Current recommendations suggest a first booster vaccine be administered 3 years after a conventional regimen or 12-18 months after a rapid regimen. However, the research supporting subsequent booster intervals is limited. The aim of this study was thus to evaluate the long-term persistence of TBE antibodies in adults and adolescents after a first booster dose with Encepur(®). A total of 323 subjects aged 15 years and over, who had received one of four different primary TBE vaccination series in a parent study, participated in this follow-up Phase IV trial. Immunogenicity and safety were assessed for up to five years after a first booster dose, which was administered three years after completion of the primary series. One subset of subjects was excluded from the booster vaccination since they had already received their booster prior to enrollment. For comparison, immune responses were still recorded for these subjects on Day 0 and on an annual basis until Year 5, but safety information was not collected. Following a booster vaccination, high antibody titers were recorded in all groups throughout the study. Neutralization test (NT) titers of ≥ 10 were noted in at least 94% of subjects at every time point post-booster (on Day 21 and through Years 1-5). These results demonstrated that a first booster vaccination following any primary immunization schedule results in high and long-lasting (>5 years) immune responses. These data lend support to the current belief that subsequent TBE booster intervals could be extended from the current recommendation. NCT00387634. Copyright © 2014 Elsevier Ltd. All rights reserved.

Modelling the effects of booster dose vaccination schedules and recommendations for public health immunization programs: the case of Haemophilus influenzae serotype b.

PubMed

Charania, Nadia A; Moghadas, Seyed M

2017-09-13

Haemophilus influenzae serotype b (Hib) has yet to be eliminated despite the implementation of routine infant immunization programs. There is no consensus regarding the number of primary vaccine doses and an optimal schedule for the booster dose. We sought to evaluate the effect of a booster dose after receiving the primary series on the long-term disease incidence. A stochastic model of Hib transmission dynamics was constructed to compare the long-term impact of a booster vaccination and different booster schedules after receiving the primary series on the incidence of carriage and symptomatic disease. We parameterized the model with available estimates for the efficacy of Hib conjugate vaccine and durations of both vaccine-induced and naturally acquired immunity. We found that administering a booster dose substantially reduced the population burden of Hib disease compared to the scenario of only receiving the primary series. Comparing the schedules, the incidence of carriage for a 2-year delay (on average) in booster vaccination was comparable or lower than that observed for the scenario of booster dose within 1 year after primary series. The temporal reduction of symptomatic disease was similar in the two booster schedules, suggesting no superiority of one schedule over the other in terms of reducing the incidence of symptomatic disease. The findings underscore the importance of a booster vaccination for continued decline of Hib incidence. When the primary series provides a high level of protection temporarily, delaying the booster dose (still within the average duration of protection conferred by the primary series) may be beneficial to maintain longer-term protection levels and decelerate the decline of herd immunity in the population.

Redshift Properties of MASIV Sources

DTIC Science & Technology

2010-06-01

34 (CBS, Marcha et a12001, Caccianiga et a12002a) is closest to MASIV however it also has weak (SS.GGH. -lmJy), but only optically bright (R::=;17.5...2001 ApJ, 546, 964 Lovell, J.E .. J, et a1. 2003 AJ, 126, 1699 Lovell, J.E.J, et a1. 2008 ApJ, 689, 108 Marcha , M.J.M, et a1. 2001 lvINRAS, 326, 1455

The effectiveness of booster sessions in CBT treatment for child and adolescent mood and anxiety disorders.

PubMed

Gearing, Robin E; Schwalbe, Craig S J; Lee, RaeHyuck; Hoagwood, Kimberly E

2013-09-01

To investigate the effects of booster sessions in cognitive behavioral therapy (CBT) for children and adolescents with mood or anxiety disorders, whereas controlling for youth demographics (e.g., gender, age), primary diagnosis, and intervention characteristics (e.g., treatment modality, number of sessions). Electronic databases were searched for CBT interventions for youth with mood and anxiety disorders. Fifty-three (k = 53) studies investigating 1,937 youth met criteria for inclusion. Booster sessions were examined using two case-controlled effect sizes: pre-post and pre-follow-up (6 months) effect sizes and employing weighted least squares (WLSs) regressions. Meta-analyses found pre-post studies with booster sessions had a larger effect size r = .58 (k = 15; 95% CI = 0.52-0.65; P < .01) than those without booster sessions r = .45 (k = 38; 95% CI = 0.41-0.49; P < .001). In the WLS regression analyses, controlling for demographic factors, primary diagnosis, and intervention characteristics, studies with booster sessions showed larger pre-post effect sizes than those without booster sessions (B = 0.13, P < .10). Similarly, pre-follow-up studies with booster sessions showed a larger effect size r = .64 (k = 10; 95% CI = 0.57-0.70; P < .10) than those without booster sessions r = .48 (k = 20; 95% CI = 0.42-0.53; P < .01). Also, in the WLS regression analyses, pre-follow-up studies showed larger effect sizes than those without booster sessions (B = 0.08, P < .01) after accounting for all control variables. Result suggests that CBT interventions with booster sessions are more effective and the effect is more sustainable for youth managing mood or anxiety disorders than CBT interventions without booster sessions. © 2013 Wiley Periodicals, Inc.

Randomized, open-label study of the impact of age on booster responses to the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine in children in India.

PubMed

Lalwani, Sanjay; Chatterjee, Sukanta; Chhatwal, Jugesh; Simon, Anna; Ravula, Sudheer; Francois, Nancy; Mehta, Shailesh; Strezova, Ana; Borys, Dorota

2014-09-01

In this phase III, open-label, multicenter, and descriptive study in India, children primed with 3 doses (at ages 6, 10, and 14 weeks) of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) were randomized (1:1) to receive a booster dose at 9 to 12 (early booster) or 15 to 18 months old (late booster) in order to evaluate impact of age at booster. We also evaluated a 2-dose catch-up vaccination plus an experimental booster dose in unprimed children age 12 to 18 months. The early booster, late booster, and catch-up vaccinations were administered to 74, 95, and 87 children, respectively; 66, 71, and 81 children, respectively, were included in the immunogenicity according-to-protocol cohort. One month postbooster, for each PHiD-CV serotype, ≥95.2% (early booster) and ≥93.8% (late booster) of the children had antibody concentrations of ≥0.2 μg/ml; ≥96.7% and ≥93.0%, respectively, had opsonophagocytic activity (OPA) titers of ≥8. The postbooster antibody geometric mean concentrations (GMCs) were in similar ranges for early and late boosters; the OPA titers appeared to be lower for most PHiD-CV serotypes (except 6B and 19F) after the early booster. After dose 2 and postbooster, for each PHiD-CV serotype, ≥88.6% and ≥96.3%, respectively, of the catch-up immunogenicity according-to-protocol cohort had antibody concentrations of ≥0.2 μg/ml; ≥71.4% and ≥90.6%, respectively, had OPA titers of ≥8. At least 1 serious adverse event was reported by 2 children in the early booster (skin infection and gastroenteritis) and 1 child in the catch-up group (febrile convulsion and urinary tract infection); all were resolved, and none were considered by the investigators to be vaccine related. PHiD-CV induced robust immune responses regardless of age at booster. Booster vaccination following 2 catch-up doses induced robust immune responses indicative of effective priming and immunological memory. (These studies have been registered at www.clinicaltrials.gov under registration no. NCT01030822 and NCT00814710; a protocol summary is available at www.gsk-clinicalstudyregister.com [study ID 112909]). Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Evolution of the APETALA2 Gene Lineage in Seed Plants.

PubMed

Zumajo-Cardona, Cecilia; Pabón-Mora, Natalia

2016-07-01

Gene duplication is a fundamental source of functional evolutionary change and has been associated with organismal diversification and the acquisition of novel features. The APETALA2/ETHYLENE RESPONSIVE ELEMENT-BINDING FACTOR (AP2/ERF) genes are exclusive to vascular plants and have been classified into the AP2-like and ERF-like clades. The AP2-like clade includes the AINTEGUMENTA (ANT) and the euAPETALA2 (euAP2) genes, both regulated by miR172 Arabidopsis has two paralogs in the euAP2 clade, namely APETALA2 (AP2) and TARGET OF EAT3 (TOE3) that control flowering time, meristem determinacy, sepal and petal identity and fruit development. euAP2 genes are likely functionally divergent outside Brassicaceae, as they control fruit development in tomato, and regulate inflorescence meristematic activity in maize. We studied the evolution and expression patterns of euAP2/TOE3 genes to assess large scale and local duplications and evaluate protein motifs likely related with functional changes across seed plants. We sampled euAP2/TOE3 genes from vascular plants and have found three major duplications and a few taxon-specific duplications. Here, we report conserved and new motifs across euAP2/TOE3 proteins and conclude that proteins predating the Brassicaceae duplication are more similar to AP2 than TOE3. Expression data show a shift from restricted expression in leaves, carpels, and fruits in non-core eudicots and asterids to a broader expression of euAP2 genes in leaves, all floral organs and fruits in rosids. Altogether, our data show a functional trend where the canonical A-function (sepal and petal identity) is exclusive to Brassicaceae and it is likely not maintained outside of rosids. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Humoral and B-cell memory responses in children five years after pertussis acellular vaccine priming.

PubMed

Carollo, Maria; Pandolfi, Elisabetta; Tozzi, Alberto Eugenio; Buisman, Anne-Marie; Mascart, Françoise; Ausiello, Clara Maria

2014-04-11

The resurgence of pertussis suggests the need for greater efforts in understanding the long-lasting protective responses induced by vaccination. In this paper we dissect the persistence of humoral and B-cell memory responses induced by primary vaccination with two different acellular pertussis (aP) vaccines, hexavalent Hexavac(®) vaccine (Hexavac) (Sanofi Pasteur MSD) and Infanrix hexa(®) (Infanrix) (GlaxoSmithKline Biologicals). We evaluated the specific immune responses in the two groups of children, 5 years after primary vaccination by measuring the persistence of IgG and antibody secreting cells (ASC) specific for vaccine antigens. Part of the enrolled children received only primary vaccination, while others had the pre-school boost dose. A similar level of antigen-specific IgG and ASC was found in Infanrix and Hexavac vaccinated children. The mean IgG levels were significantly higher in children that received the pre-school boost as compared with children that did not receive the boost dose. A longer persistence after the pre-school boost of IgG-Pertussis Toxin (PT) and IgG-pertactin levels was observed in Infanrix primed children, but it was not statistically significant. More than 80% of children presented a positive ASC B memory response. Around 50% of children still presented protective IgG-PT levels which are reduced to 36% in no-boosted children. The pre-school booster dose restores the percentage of protected children above 50%. In conclusion our data underline the importance of giving a booster dose 5 years after primary vaccination and suggest the need for a new vaccine able to induce a long lasting protective response. Copyright © 2014 Elsevier Ltd. All rights reserved.

The Pseudomonas aeruginosa Catabolite Repression Control Protein Crc Is Devoid of RNA Binding Activity

PubMed Central

Djinovic-Carugo, Kristina; Bläsi, Udo

2013-01-01

The Crc protein has been shown to mediate catabolite repression control in Pseudomonas, leading to a preferential assimilation of carbon sources. It has been suggested that Crc acts as a translational repressor of mRNAs, encoding functions involved in uptake and breakdown of different carbon sources. Moreover, the regulatory RNA CrcZ, the level of which is increased in the presence of less preferred carbon sources, was suggested to bind to and sequester Crc, resulting in a relief of catabolite repression. Here, we determined the crystal structure of Pseudomonas aeruginosa Crc, a member of apurinic/apyrimidinic (AP) endonuclease family, at 1.8 Å. Although Crc displays high sequence similarity with its orthologs, there are amino acid alterations in the area corresponding to the active site in AP proteins. Unlike typical AP endonuclease family proteins, Crc has a reduced overall positive charge and the conserved positively charged amino-acid residues of the DNA-binding surface of AP proteins are partially substituted by negatively charged, polar and hydrophobic residues. Crc protein purified to homogeneity from P. aeruginosa did neither display DNase activity, nor did it bind to previously identified RNA substrates. Rather, the RNA chaperone Hfq was identified as a contaminant in His-tagged Crc preparations purified by one step Ni-affinity chromatography from Escherichia coli, and was shown to account for the RNA binding activity observed with the His-Crc preparations. Taken together, these data challenge a role of Crc as a direct translational repressor in carbon catabolite repression in P. aeruginosa. PMID:23717639

The Pseudomonas aeruginosa catabolite repression control protein Crc is devoid of RNA binding activity.

PubMed

Milojevic, Tetyana; Grishkovskaya, Irina; Sonnleitner, Elisabeth; Djinovic-Carugo, Kristina; Bläsi, Udo

2013-01-01

The Crc protein has been shown to mediate catabolite repression control in Pseudomonas, leading to a preferential assimilation of carbon sources. It has been suggested that Crc acts as a translational repressor of mRNAs, encoding functions involved in uptake and breakdown of different carbon sources. Moreover, the regulatory RNA CrcZ, the level of which is increased in the presence of less preferred carbon sources, was suggested to bind to and sequester Crc, resulting in a relief of catabolite repression. Here, we determined the crystal structure of Pseudomonas aeruginosa Crc, a member of apurinic/apyrimidinic (AP) endonuclease family, at 1.8 Å. Although Crc displays high sequence similarity with its orthologs, there are amino acid alterations in the area corresponding to the active site in AP proteins. Unlike typical AP endonuclease family proteins, Crc has a reduced overall positive charge and the conserved positively charged amino-acid residues of the DNA-binding surface of AP proteins are partially substituted by negatively charged, polar and hydrophobic residues. Crc protein purified to homogeneity from P. aeruginosa did neither display DNase activity, nor did it bind to previously identified RNA substrates. Rather, the RNA chaperone Hfq was identified as a contaminant in His-tagged Crc preparations purified by one step Ni-affinity chromatography from Escherichia coli, and was shown to account for the RNA binding activity observed with the His-Crc preparations. Taken together, these data challenge a role of Crc as a direct translational repressor in carbon catabolite repression in P. aeruginosa.

Evaluation of actuator energy storage and power sources for spacecraft applications

NASA Technical Reports Server (NTRS)

Simon, William E.; Young, Fred M.

1993-01-01

The objective of this evaluation is to determine an optimum energy storage/power source combination for electrical actuation systems for existing (Solid Rocket Booster (SRB), Shuttle) and future (Advanced Launch System (ALS), Shuttle Derivative) vehicles. Characteristic of these applications is the requirement for high power pulses (50-200 kW) for short times (milliseconds to seconds), coupled with longer-term base or 'housekeeping' requirements (5-16 kW). Specific study parameters (e.g., weight, volume, etc.) as stated in the proposal and specified in the Statement of Work (SOW) are included.

47 CFR 74.763 - Time of operation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Booster Stations § 74.763 Time of operation. (a) A low power TV, TV translator, or TV booster station is... or TV booster station is expected to provide service to the extent that such is within its control... necessary. (c) Failure of a low power TV, TV translator, or TV booster station to operate for a period of 30...

Competence in Lexical Boosters and Nativeness in Academic Writing of English: The Possible Relation

ERIC Educational Resources Information Center

Demir, Cüneyt

2017-01-01

Boosters are an important metadiscourse device for writers because it creates an emphatic impression in the reader. In addition, the competence of metadiscourse devices such as boosters is crucial in having native-fluency in academic writing. Therefore, this avoidance of using boosters may spawn foreignness in non-native writers' academic texts.…

47 CFR 74.763 - Time of operation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Booster Stations § 74.763 Time of operation. (a) A low power TV, TV translator, or TV booster station is... or TV booster station is expected to provide service to the extent that such is within its control... necessary. (c) Failure of a low power TV, TV translator, or TV booster station to operate for a period of 30...

47 CFR 73.827 - Interference to the input signals of FM translator or FM booster stations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... translator or FM booster stations. 73.827 Section 73.827 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Interference to the input signals of FM translator or FM booster stations. (a) An authorized LPFM station will not be permitted to continue to operate if an FM translator or FM booster station demonstrates that...

47 CFR 74.763 - Time of operation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Booster Stations § 74.763 Time of operation. (a) A low power TV, TV translator, or TV booster station is... or TV booster station is expected to provide service to the extent that such is within its control... necessary. (c) Failure of a low power TV, TV translator, or TV booster station to operate for a period of 30...

47 CFR 73.827 - Interference to the input signals of FM translator or FM booster stations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... translator or FM booster stations. 73.827 Section 73.827 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Interference to the input signals of FM translator or FM booster stations. (a) Interference to the direct... continue to operate if an FM translator or FM booster station demonstrates that the LPFM station is causing...

47 CFR 73.827 - Interference to the input signals of FM translator or FM booster stations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... translator or FM booster stations. 73.827 Section 73.827 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Interference to the input signals of FM translator or FM booster stations. (a) An authorized LPFM station will not be permitted to continue to operate if an FM translator or FM booster station demonstrates that...

47 CFR 74.763 - Time of operation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Booster Stations § 74.763 Time of operation. (a) A low power TV, TV translator, or TV booster station is... or TV booster station is expected to provide service to the extent that such is within its control... necessary. (c) Failure of a low power TV, TV translator, or TV booster station to operate for a period of 30...

47 CFR 73.827 - Interference to the input signals of FM translator or FM booster stations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... translator or FM booster stations. 73.827 Section 73.827 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Interference to the input signals of FM translator or FM booster stations. (a) Interference to the direct... authorized LPFM station will not be permitted to continue to operate if an FM translator or FM booster...

47 CFR 73.3572 - Processing of TV broadcast, Class A TV broadcast, low power TV, TV translators, and TV booster...

Code of Federal Regulations, 2010 CFR

2010-10-01

... broadcast, low power TV, TV translators, and TV booster applications. 73.3572 Section 73.3572..., low power TV, TV translators, and TV booster applications. (a) Applications for TV stations are..., TV translator, and TV booster stations authorized under part 74 of this chapter, a major change is...

47 CFR 73.827 - Interference to the input signals of FM translator or FM booster stations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... translator or FM booster stations. 73.827 Section 73.827 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Interference to the input signals of FM translator or FM booster stations. (a) An authorized LPFM station will not be permitted to continue to operate if an FM translator or FM booster station demonstrates that...

Economic considerations and health in all policies initiatives: evidence from interviews with key informants in Sweden, Quebec and South Australia.

PubMed

Pinto, Andrew D; Molnar, Agnes; Shankardass, Ketan; O'Campo, Patricia J; Bayoumi, Ahmed M

2015-02-18

Health in All Policies (HiAP) is a form of intersectoral action that aims to include the promotion of health in government initiatives across sectors. To date, there has been little study of economic considerations within the implementation of HiAP. As part of an ongoing program of research on the implementation of HiAP around the world, we examined how economic considerations influence the implementation of HiAP. By economic considerations we mean the cost and financial gain (or loss) of implementing a HiAP process or structure within government, or the cost and financial gain (or loss) of the policies that emerge from such a HiAP process or structure. We examined three jurisdictions: Sweden, Quebec and South Australia. Semi-structured telephone interviews were conducted with 12 to 14 key informants in each jurisdiction. Two investigators separately coded transcripts to identify relevant statements. Initial readings of transcripts led to the development of a coding framework for statements related to economic considerations. First, economic evaluations of HiAP are viewed as important for prompting HiAP and many forms of economic evaluation were considered. However, economic evaluations were often absent, informal, or incomplete. Second, funding for HiAP initiatives is important, but is less important than a high-level commitment to intersectoral collaboration. Furthermore, having multiple sources of funding of HiAP can be beneficial, if it increases participation across government, but can also be disadvantageous, if it exposes underlying tensions. Third, HiAP can also highlight the challenge of achieving both economic and social objectives. Our results are useful for elaborating propositions for use in realist multiple explanatory case studies. First, we propose that economic considerations are currently used primarily as a method by health sectors to promote and legitimize HiAP to non-health sectors with the goal of securing resources for HiAP. Second, allocating resources and making funding decisions regarding HiAP are inherently political acts that reflect tensions within government sectors. This study contributes important insights into how intersectoral action works, how economic evaluations of HiAP might be structured, and how economic considerations can be used to both promote HiAP and to present barriers to implementation.

75 FR 27191 - Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR): Aggregation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Parts 51 and 52 [EPA-HQ-OAR-2003-0064, FRL-9151-3] RIN 2060-AP80 Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR... of the Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR...

Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii.

PubMed

Pateraki, Irini; Andersen-Ranberg, Johan; Jensen, Niels Bjerg; Wubshet, Sileshi Gizachew; Heskes, Allison Maree; Forman, Victor; Hallström, Björn; Hamberger, Britta; Motawia, Mohammed Saddik; Olsen, Carl Erik; Staerk, Dan; Hansen, Jørgen; Møller, Birger Lindberg; Hamberger, Björn

2017-03-14

Forskolin is a unique structurally complex labdane-type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic AMP booster. Commercial production of forskolin relies exclusively on extraction from its only known natural source, the plant Coleus forskohlii , in which forskolin accumulates in the root cork. Here, we report the discovery of five cytochrome P450s and two acetyltransferases which catalyze a cascade of reactions converting the forskolin precursor 13 R -manoyl oxide into forskolin and a diverse array of additional labdane-type diterpenoids. A minimal set of three P450s in combination with a single acetyl transferase was identified that catalyzes the conversion of 13 R -manoyl oxide into forskolin as demonstrated by transient expression in Nicotiana benthamiana . The entire pathway for forskolin production from glucose encompassing expression of nine genes was stably integrated into Saccharomyces cerevisiae and afforded forskolin titers of 40 mg/L.

Results from the RF BPM Upgrade Prototype at the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pietryla, Anthony; Lill, Robert; Norum, Eric

2006-11-20

The Advanced Photon Source (APS), a third-generation synchrotron light source, has been in operation for 10 years. The monopulse radio frequency (RF) beam position monitor (BPM) is one of three BPM types now employed in the storage ring at the APS. It is a broadband (10 MHz) system designed to measure single-turn and multi-turn beam positions, but it suffers from an aging data acquisition system. The replacement BPM system retains the existing monopulse receivers and replaces the data acquisition system with high-speed analog-to-digital converters (ADCs) and a field programmable gate array (FPGA) that performs the signal processing. A prototype systemmore » was constructed and is currently being evaluated. This paper presents the results obtained from laboratory and field tests of the prototype system.« less

Results from the RF BPM upgrade prototype at the Advanced Photon Source.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pietryla, A.; Lill, R.; Norum, E.

2006-01-01

The Advanced Photon Source (APS), a third-generation synchrotron light source, has been in operation for 10 years. The monopulse radio frequency (RF) beam position monitor (BPM) is one of three BPM types now employed in the storage ring at the APS. It is a broadband (10 MHz) system designed to measure single-turn and multi-turn beam positions, but it suffers from an aging data acquisition system. The replacement BPM system retains the existing monopulse receivers and replaces the data acquisition system with high-speed analog-to-digital converters (ADCs) and a field programmable gate array (FPGA) that performs the signal processing. A prototype systemmore » was constructed and is currently being evaluated. This paper presents the results obtained from laboratory and field tests of the prototype system.« less

Fundamental limits on beam stability at the Advanced Photon Source.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Decker, G. A.

1998-06-18

Orbit correction is now routinely performed at the few-micron level in the Advanced Photon Source (APS) storage ring. Three diagnostics are presently in use to measure and control both AC and DC orbit motions: broad-band turn-by-turn rf beam position monitors (BPMs), narrow-band switched heterodyne receivers, and photoemission-style x-ray beam position monitors. Each type of diagnostic has its own set of systematic error effects that place limits on the ultimate pointing stability of x-ray beams supplied to users at the APS. Limiting sources of beam motion at present are magnet power supply noise, girder vibration, and thermal timescale vacuum chamber andmore » girder motion. This paper will investigate the present limitations on orbit correction, and will delve into the upgrades necessary to achieve true sub-micron beam stability.« less

Booster and higher antigen doses of inactivated influenza vaccine in HIV-infected patients.

PubMed

Johnston, Jessica A; Tincher, Lindsey B; Lowe, Denise K

2013-12-01

To review the literature regarding booster or higher doses of influenza antigen for increasing immunogenicity of inactivated influenza vaccine (IIV) in HIV-infected patients. MEDLINE (1966 to September 2013) was searched using the terms immunize, influenza, vaccine, and HIV or AIDS in combination with two-dose, booster-dose, increased antigen, or high-dose. One trial of booster dosing with standard doses (SDs) of IIV, trivalent (IIV3); 2 trials of booster dosing with intermediate doses (ID) of H1N1 IIV or IIV3; and 1 trial of high-dose (HD) IIV3 were identified. Trials administering 2-dose, booster-dose, or increased antigen of influenza vaccine to patients with HIV were reviewed. Because adjuvanted IIV is not available and IIV, quadrivalent was recently approved in the United States, studies evaluating these vaccines were excluded. HIV-infected individuals are at high risk for influenza-related complications; however, vaccination with SD IIV may not confer optimal protection. It has been postulated that booster or higher doses of influenza antigen may lead to increased immunogenicity. When ID and SD or ID with boosters were evaluated in HIV-infected patients, significant increases in surrogate markers for influenza protection were not achieved. However, HD IIV3 did result in significant increases in seroprotective antibody levels, though 'clinical' influenza was not evaluated. Currently, evidence is insufficient to reach conclusions about the efficacy of booster dosing, ID, or HD influenza vaccine in HIV-infected patients. Trials evaluating booster or higher-antigen doses of IIV for 'clinical' influenza are necessary before routinely recommending for HIV-infected patients.

Safety and immunogenicity of a booster dose of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults: A randomized phase 1 study.

PubMed

Marshall, Helen; Nissen, Michael; Richmond, Peter; Shakib, Sepehr; Jiang, Qin; Cooper, David; Rill, Denise; Baber, James; Eiden, Joseph; Gruber, William C; Jansen, Kathrin U; Anderson, Annaliesa S; Zito, Edward T; Girgenti, Douglas

2016-11-01

A 2-stage, phase 1, randomized, placebo-controlled study in healthy adults to assess immunogenicity and safety of a booster dose at three dose levels of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) containing recombinant clumping factor A (ClfA) and capsular polysaccharides 5 and 8 (CP5 and CP8) conjugated to a diphtheria toxoid. Six months after initial single vaccination, in Stage 2, SA3Ag recipients were randomized (1:1) to booster vaccination or placebo, while Stage 1 placebo recipients received placebo again. Pre- and post-vaccination blood samples were analyzed. In Stage 2 (n = 345), pre-booster CP5 and CP8 titers remained high with no increase post-booster. ClfA titers remained high after initial vaccination and increased post-booster, approaching the peak response to the initial dose. Post-booster local reactions were more frequent and of greater severity than reported after the initial vaccination, particularly for the high-dose level recipients. Post hoc analysis showed no dose-response pattern and no obvious association between diphtheria toxoid titers and local reactions after initial or booster vaccination. Immune responses after the initial vaccination persisted for the 12 months studied, with little additional response after the booster dose at 6 months. Post-booster injection site reactions were more frequent and more severe but self-limiting. CLINICALTRIALS. NCT01018641. Copyright © 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Evaluation of Safe Kids Week 2004: Age 4 to 9? It's Booster Seat Time!

PubMed Central

Howard, A; Beben, N; Rothman, L; Fiissel, D; MacArthur, C

2006-01-01

Objective To assess the effectiveness of a national one week media campaign promoting booster seat use. Design Pre‐test, post‐test design based on nationally representative random digit dialing telephone survey, with control for exposure to campaign. Setting Canada. Subjects Parents of children aged 4–9 years. Interventions During a one week campaign in May 2004, information on booster seat use was distributed via a national media campaign, retail stores, medical clinics, and community events. Information included pamphlets with guidelines for booster seat use, as well as a growth chart (designed by Safe Kids Canada) to assist parents in determining if their child should be using a booster seat. Assessing seat belt fit was described in detail on the growth chart. Main outcome measures Knowledge, attitudes, and self‐reported behaviors regarding booster seat use. Results Respondents in the group exposed to the campaign were twice as likely to report using a booster seat with lap and shoulder belt for their child (47%), compared to those in the pre‐test (24%) and the unexposed (23%) groups (p<0.001). However, only small differences in general knowledge regarding booster seat use were found between the groups. Conclusions A one week national media campaign substantially increased self‐reported use of booster seats. Parents did not remember details of the campaign content, but did remember implications for their own child. PMID:17018673

Promoting booster seat use for young children: A school-based intervention pilot study

PubMed Central

Mundle, Kim; Cramm, Camille F.; Williams, Devon P.

2017-01-01

Abstract Purpose: Misuse and/or lack of booster seat use are often associated with high rates of injury and death among school-aged children. This pilot study examined the efficacy and the potential effectiveness of a booster seat intervention in the classroom. Methods: Two elementary schools participated (randomly assigned as one intervention school and one control school). At the intervention school, a certified car seat specialist and a police officer held an interactive booster seat session. The height and age for each child were recorded. Children received a certificate indicating whether they met the requirements for booster seat use and a postcard with car seat restraint specifications. Children in the control school received a brochure on car seat safety. Pre- and post-intervention self-reports were collected and booster seat use was observed. Results: Observational findings showed a decline in booster seat use at the control school and an increase in use at the intervention school. Self-reports of booster seat use indicated a decline at both schools; however, cell sizes were too small to permit statistical analyses. Conclusion: Anecdotally researchers found the sessions were easy to conduct and were well received by the children and could be easily integrated into programming in schools. Classroom sessions may have the potential to positively influence booster seat use among 6- to 8-year-olds. PMID:29479188

KSC-06pd1505

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - At the dock at Hangar AF, Cape Canaveral Air Force Station, workers move the spent solid rocket booster away from the SRB Retrieval Ship Liberty Star to an area beneath the straddle crane that will lift it out of the water. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-06pd1504

NASA Image and Video Library

2006-07-06

KENNEDY SPACE CENTER, FLA. - At the dock at Hangar AF, Cape Canaveral Air Force Station, workers move the spent solid rocket booster away from the SRB Retrieval Ship Liberty Star to an area beneath the straddle crane that will lift it out of the water. The booster is from Space Shuttle Discovery, which launched on July 4. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and ,after transfer to a position alongside the ship, to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/George Shelton

KSC-2009-2139

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, one of the solid rocket boosters used during space shuttle Discovery's launch March 15 on mission STS-119 is moved to an area beneath the straddle crane that will lift it out of the water. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-2009-2145

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, a solid rocket boosters used during space shuttle Discovery's launch from NASA's Kennedy Space Center in Florida March 15 on mission STS-119 waits in an area beneath the straddle crane that will lift it out of the water. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd3736

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, workers prepare to move the spent solid rocket booster to the hangar for the safing process. It will be driven through the washing bay for a cleaning and rinsing. The booster is from space shuttle Endeavour, which launched Nov. 14 on the STS-126 mission. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

KSC-08pd3732

NASA Image and Video Library

2008-11-19

CAPE CANAVERAL, Fla. – At the dock at Hangar AF at Cape Canaveral Air Force Station in Florida, the spent solid rocket booster from space shuttle Endeavour's launch Nov. 14 on mission STS-126 is moved to an area beneath the straddle crane that will lift it out of the water. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The spent rocket was recovered by NASA's Solid Rocket Booster Retrieval Ship Freedom Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Kim Shiflett

[Safety and immunogenicity of a 7-valent pneumococcal conjugate vaccine (Prevenar) booster dose in healthy Chinese toddlers].

PubMed

Li, Rong-cheng; Li, Feng-xiang; Li, Yan-ping

2009-06-01

To evaluate the safety and immunogenicity of the booster dose of 7 valent pneumococcal conjugate vaccine (PCV7) to the healthy Chinese toddlers who had received 3 primary doses. Four hundred and eighty-eight Chinese toddlers received a booster dose of PCV7 at age of 12-15 months following a primary series of the vaccine given at ages 3, 4, 5 months separately with Diphtheria Tetanus Acellular Pertussis Combined Vaccine (DTaP) in Group 1 or concurrently with DTaP in Group 2. Following the booster dose immunization, each subject was followed up for 30 days to observe the safety of the vaccine. Blood samples were taken from a subset of subjects prior and post 30 days the booster dose immunization to evaluate immunogenicity. A high proportion of subjects in Group 1 (89%) and Group 2 (91%) remained afebrile after the booster dose. Local reactions to the PCV7 booster dose were generally mild. For each serotype, the rise in GMC (post-/pre-vaccination) showed a statistically significant difference (P<0.0001) between both groups. PCV7 administered as a booster dose is generally safe, well tolerate, and immunogenic in healthy Chinese toddlers.

Fabrication and assembly of a superconducting undulator for the advanced photon source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hasse, Quentin; Fuerst, J. D.; Ivanyushenkov, Y.

2014-01-29

A prototype superconducting undulator magnet (SCU0) has been built at the Advanced Photon Source (APS) of Argonne National Laboratory (ANL) and has successfully completed both cryogenic performance and magnetic measurement test programs. The SCU0 closed loop, zero-boil-off cryogenic system incorporates high temperature superconducting (HTS) current leads, cryocoolers, a LHe reservoir supplying dual magnetic cores, and an integrated cooled beam chamber. This system presented numerous challenges in the design, fabrication, and assembly of the device. Aspects of this R and D relating to both the cryogenic and overall assembly of the device are presented here. The SCU0 magnet has been installedmore » in the APS storage ring.« less

Mechanical design of thin-film diamond crystal mounting apparatus for coherence preservation hard x-ray optics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shu, Deming, E-mail: shu@aps.anl.gov; Shvyd’ko, Yuri V.; Stoupin, Stanislav

2016-07-27

A new thin-film diamond crystal mounting apparatus has been designed at the Advanced Photon Source (APS) for coherence preservation hard x-ray optics with optimized thermal contact and minimized crystal strain. This novel mechanical design can be applied to new development in the field of: x-ray optics cavities for hard x-ray free-electron laser oscillators (XFELOs), self-seeding monochromators for hard x-ray free-electron laser (XFEL) with high average thermal loading, high heat load diamond crystal monochromators and beam-sharing/beam-split-and-delay devices for XFEL facilities and future upgraded high-brightness coherent x-ray source in the MBA lattice configuration at the APS.

Development of a Hard X-ray Beam Position Monitor for Insertion Device Beams at the APS

NASA Astrophysics Data System (ADS)

Decker, Glenn; Rosenbaum, Gerd; Singh, Om

2006-11-01

Long-term pointing stability requirements at the Advanced Photon Source (APS) are very stringent, at the level of 500 nanoradians peak-to-peak or better over a one-week time frame. Conventional rf beam position monitors (BPMs) close to the insertion device source points are incapable of assuring this level of stability, owing to mechanical, thermal, and electronic stability limitations. Insertion device gap-dependent systematic errors associated with the present ultraviolet photon beam position monitors similarly limit their ability to control long-term pointing stability. We report on the development of a new BPM design sensitive only to hard x-rays. Early experimental results will be presented.

NASA's Space Launch System Booster Passes Major Milestone on Journey to Mars (QM-2)

NASA Image and Video Library

2016-06-28

A booster for the most powerful rocket in the world, NASA’s Space Launch System (SLS), was fired up Tuesday, June 28 at 11:05 a.m. EDT for a second qualification ground test at Orbital ATK's test facilities in Promontory, Utah. This was the last full-scale test for the booster before SLS is ready in 2018 for the first uncrewed test flight with NASA’s Orion spacecraft, marking a key milestone on the agency’s Journey to Mars. The booster was tested at a cold motor conditioning target of 40 degrees Fahrenheit –the colder end of its accepted propellant temperature range. When ignited, temperatures inside the booster reached nearly 6,000 degrees. The two-minute, full-duration ground qualification test provided NASA with critical data on 82 qualification objectives that will support certification of the booster for flight. Engineers now will evaluate test data captured by more than 530 instrumentation channels on the booster.

Analysis of delayed TBE-vaccine booster after primary vaccination.

PubMed

Aerssens, Annelies; Cochez, Christel; Niedrig, Matthias; Heyman, Paul; Kühlmann-Rabens, Ilona; Soentjens, Patrick

2016-02-01

An open, uncontrolled single centre study was conducted in the Travel Clinic at the Military Hospital, Brussels. Eighty-eight subjects were recruited who had a primary series of tick-borne encephalitis (TBE) vaccine more than 5 years ago and who never received a booster dose afterwards. Response rate after booster vaccination was very high: 84 out of 88 subjects (95.5%) had neutralizing antibodies on plaque reduction neutralization test and all (100%) had IgG antibodies on ELISA, on Day 21-28 after booster vaccination. This study adds valuable information to the common situation of delayed booster interval. The results of our study indicate that in young healthy travellers (<50 years), one booster vaccination after a primary series of TBE vaccine in the past is sufficient to obtain protective antibodies, even if primary vaccination is much longer than the recommended booster interval of 5 years. © International Society of Travel Medicine, 2016. All rights reserved.For permissions, please e-mail: journals.permissions@oup.com.

Design of 3 GeV booster ring lattice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Etisken, O., E-mail: ozgur.etisken@cern.ch; Ciftci, A. K., E-mail: abbas.kenan.ciftci@cern.ch

2016-03-25

The aim of this study is to design of a 3 GeV booster ring for the 3 GeV storage ring. Electrons are needed to be accelerated to 3.0 GeV from 0.15 GeV energy. In this frame, we studied on two options for booster ring; a compact booster and the booster that shares the same tunnel with the storage ring. The lattice type has been chosen FODO for both options, lattice parameters are calculated, sextupole magnets are used to decrease dynamic aperture problem and dynamic aperture calculations are also made with considering of the necessary conditions. After designing and calculating ofmore » the parameters, these designs have been compared with each other. In addition to this comparison, these booster design parameters have been compared with some world centers design parameters and the reliability of the booster design is seen. Beam optics, OPA and Elegant simulation programs have been used in the study calculations.« less

A study of two statistical methods as applied to shuttle solid rocket booster expenditures

NASA Technical Reports Server (NTRS)

Perlmutter, M.; Huang, Y.; Graves, M.

1974-01-01

The state probability technique and the Monte Carlo technique are applied to finding shuttle solid rocket booster expenditure statistics. For a given attrition rate per launch, the probable number of boosters needed for a given mission of 440 launches is calculated. Several cases are considered, including the elimination of the booster after a maximum of 20 consecutive launches. Also considered is the case where the booster is composed of replaceable components with independent attrition rates. A simple cost analysis is carried out to indicate the number of boosters to build initially, depending on booster costs. Two statistical methods were applied in the analysis: (1) state probability method which consists of defining an appropriate state space for the outcome of the random trials, and (2) model simulation method or the Monte Carlo technique. It was found that the model simulation method was easier to formulate while the state probability method required less computing time and was more accurate.

APS-U LATTICE DESIGN FOR OFF-AXIS ACCUMULATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Yipeng; Borland, M.; Lindberg, R.

2017-06-25

A 67-pm hybrid-seven-bend achromat (H7BA) lattice is being proposed for a future Advanced Photon Source (APS) multi-bend-achromat (MBA) upgrade project. This lattice design pushes for smaller emittance and requires use of a swap-out (on-axis) injection scheme due to limited dynamic acceptance. Alternate lattice design work has also been performed for the APS upgrade to achieve better beam dynamics performance than the nominal APS MBA lattice, in order to allow off-axis accumulation. Two such alternate H7BA lattice designs, which target a still-low emittance of 90 pm, are discussed in detail in this paper. Although the single-particle-dynamics performance is good, simulations ofmore » collective effects indicate that surprising difficulty would be expected accumulating high single-bunch charge in this lattice. The brightness of the 90-pm lattice is also a factor of two lower than the 67-pm H7BA lattice.« less

VizieR Online Data Catalog: Candidate X-ray OB stars in MYStIX regions (Povich+, 2017)

NASA Astrophysics Data System (ADS)

Povich, M. S.; Busk, H. A.; Feigelson, E. D.; Townsley, L. K.; Kuhn, M. A.

2017-10-01

X-ray point source catalogs for the 18 Massive Young Star-forming Complex Study in Infrared and X-Rays (MYStIX) regions studied here were produced by Kuhn+ (2010, J/ApJ/725/2485 and 2013, J/ApJS/209/27) and Townsley (2014+, J/ApJS/213/1) from archival Chandra Advanced CCD Imaging Camera (ACIS) observations. MYStIX JHKs NIR photometry was obtained from images taken with the United Kingdom Infrared Telescope (UKIRT) Wide-field Camera or from the Two-Micron All-Sky Survey (2MASS). See section 2 for further details. Spitzer MIR photometry at 3.6, 4.5, 5.8, and 8.0um was provided either by the Galactic Legacy Mid-Plane Survey Extraordinaire (GLIMPSE; Benjamin+ 2003PASP..115..953B) or by Kuhn+ (2013, J/ApJS/209/29). (4 data files).

Aerodynamic characterisation and trajectory simulations for the Ariane-5 booster recovery system

NASA Astrophysics Data System (ADS)

Meiboom, F. P.

One of the most critical aspects of the early phases of the development of the Ariane-5 booster recovery system was the determination of the behavior of the booster during its atmospheric reentry, since this behavior determines the start conditions for the parachute system elements. A combination of wind-tunnel tests (subsonic and supersonic) and analytical methods was applied to define the aerodynamic characteristics of the booster. This aerodynamic characterization in combination with information of the ascent trajectory, atmospheric properties and booster mass and inertia were used as input for the 6-DOF trajectory simulations of the vehicle. Uncertainties in aerodynamic properties and deviations in atmospheric and booster properties were incorporated to define the range of initial conditions for the parachute system, utilizing stochastic (Monte-Carlo) methods.

SRB Processing Facilities Media Event

NASA Image and Video Library

2016-03-01

Members of the news media view forward booster segments (painted green) for NASA’s Space Launch System rocket boosters inside the Booster Fabrication Facility (BFF) at NASA’s Kennedy Space Center in Florida. Orbital ATK is a contractor for NASA’s Marshall Space Flight Center in Alabama, and operates the BFF to prepare aft booster segments and hardware for the SLS rocket boosters. The SLS rocket and Orion spacecraft will launch on Exploration Mission-1 in 2018. The Ground Systems Development and Operations Program is preparing the infrastructure to process and launch spacecraft for deep-space missions and the journey to Mars.

Closeup view of the Solid Rocket Booster Frustum and Nose ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Close-up view of the Solid Rocket Booster Frustum and Nose Cap assembly undergoing preparations and assembly procedures in the Solid Rocket Booster Assembly and Refurbishment Facility at Kennedy Space Center. The Nose Cap contains the Pilot and Drogue Chutes and the Frustum contains the three Main Parachutes, Altitude Switches and forward booster Separation Motors. In this view the assembly is rotated so that the four Separation Motors are in view and aligned with the approximate centerline of the image. - Space Transportation System, Solid Rocket Boosters, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

A systematic study on photocatalysis of antipyrine: Catalyst characterization, parameter optimization, reaction mechanism a toxicity evolution to plankton.

PubMed

Gong, Han; Chu, Wei; Chen, Meijuan; Wang, Qinxing

2017-04-01

The toxicity of antipyrine (AP) in the photodegradation using UV/CoFe 2 O 4 /TiO 2 was investigated by analyzing the characteristic of the catalyst, the effect of parameters (light source wavelength, catalyst dose, pH and initial AP concentration), the reaction mechanism (the organic intermediates, TOC reduction and inorganic ions release) and the newly proposed low-dosage-high-effective radical reaction approach. The catalyst shows the optimal removal efficiency under the conditions of wavelength at 350 nm, the catalyst dose at 0.5 g/L, and pH value at 5.5. Ten organic intermediates were identified, and five of them were newly reported in AP treatment process. Hydroxylation, demethylation and the cleavage of the pentacyclic ring were included in the decomposition pathways. The ring opening was certified by the 45% TOC reduction and 60% ammonia release during the process. The parent compound AP and its degradation products show positive effects on the growth of the algae. However, acute toxicity of AP was detected on brine shrimps Artemia salina. The toxicity was eliminated gradually with the decomposition of AP and the generation of the byproducts. The results indicate that the photocatalysis process is effective in AP removal, TOC reduction and toxicity elimination. Copyright © 2017 Elsevier Ltd. All rights reserved.

30 CFR 57.22207 - Booster fans (I-A, II-A, III, and V-A mines).

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Booster fans (I-A, II-A, III, and V-A mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22207 Booster fans (I-A, II-A, III, and V-A mines). (a) Booster fans shall be approved by MSHA under the applicable...

30 CFR 57.22207 - Booster fans (I-A, II-A, III, and V-A mines).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Booster fans (I-A, II-A, III, and V-A mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22207 Booster fans (I-A, II-A, III, and V-A mines). (a) Booster fans shall be approved by MSHA under the applicable...

30 CFR 57.22207 - Booster fans (I-A, II-A, III, and V-A mines).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Booster fans (I-A, II-A, III, and V-A mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22207 Booster fans (I-A, II-A, III, and V-A mines). (a) Booster fans shall be approved by MSHA under the applicable...

30 CFR 57.22207 - Booster fans (I-A, II-A, III, and V-A mines).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Booster fans (I-A, II-A, III, and V-A mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22207 Booster fans (I-A, II-A, III, and V-A mines). (a) Booster fans shall be approved by MSHA under the applicable...

Associations between bacteremia from oral sources and distant-site infections: tooth brushing versus single tooth extraction.

PubMed

Mougeot, Farah K Bahrani; Saunders, Sabrina E; Brennan, Michael T; Lockhart, Peter B

2015-04-01

To determine the impact of antibiotic prophylaxis (AP) on the incidence of bacteremia caused by oral bacterial species associated with infective endocarditis (IE) and prosthetic joint infections (PJIs) and to compare the incidence of following tooth brushing versus single tooth extraction. Bacterial species in blood following single tooth extraction, with or without AP, and tooth brushing(1) were compared with IE- and PJI-associated bacteria reported in the literature. Of the 98 bacterial species identified in blood following single tooth extraction and tooth brushing, 32(1) and 12 were species were associated with IE and PJI, respectively. AP decreased the frequency of IE- and PJI-causing oral bacterial species in blood; however, single tooth extraction versus brushing resulted in bacteremia with IE- and PJI-causing species with similar frequencies: 65% versus 56% for IE, and 31% versus 28% for PJI. Although AP significantly decreased the incidence of bacteremia, the similarity between the incidence of bacteremia following brushing and extraction undermines AP as an effective strategy for the prevention of these distant-site infections. Copyright © 2015 Elsevier Inc. All rights reserved.

Overview of Lattice Design and Evaluation for the APS Upgrade

DOE PAGES

Borland, M.; Emery, L.; Lindberg, R.; ...

2017-08-01

The Advanced Photon Source (APS) is a 7-GeV synchrotron light source that has been in operation since 1996. Since that time, the effective emittance has been decreased from 8 nm to 3.1 nm, which is very competitive for a 3rd-generation light source. However, newer facilities such as PETRA-III, NSLS-II, and MAX-IV are pushing the emittance to significantly smaller values. MAX-IV in particular has set the current benchmark with an emittance of about 300 pm at 3 GeV. This was accomplished by use of a multi-bend achromat lattice, which takes advantage of the 1/M3 scaling of the emittance with respect tomore » the number of dipoles M. In order to ensure that our facility remains competitive, APS is pursuing a major upgrade, which involves replacement of the existing double-bend lattice with a seven-bend achromat lattice, promising a 40-fold reduction in emittance. This paper describes the process of developing and evaluating candidate lattice designs. Two candidate 6-GeV lattices are described: one providing a natural emittance of 67 pm and the other providing 41 pm. Our analysis includes single-particle dynamics as well as single- and multi-bunch collective effects.« less

Vertically polarizing undulator with the dynamic compensation of magnetic forces for the next generation of light sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strelnikov, N.; Budker Institute of Nuclear Physics, Novosibirsk 630090; Trakhtenberg, E.

2014-11-15

A short prototype (847-mm-long) of an Insertion Device (ID) with the dynamic compensation of ID magnetic forces has been designed, built, and tested at the Advanced Photon Source (APS) of the Argonne National Laboratory. The ID magnetic forces were compensated by the set of conical springs placed along the ID strongback. Well-controlled exponential characteristics of conical springs permitted a very close fit to the ID magnetic forces. Several effects related to the imperfections of actual springs, their mounting and tuning, and how these factors affect the prototype performance has been studied. Finally, series of tests to determine the accuracy andmore » reproducibility of the ID magnetic gap settings have been carried out. Based on the magnetic measurements of the ID B{sub eff}, it has been demonstrated that the magnetic gaps within an operating range were controlled accurately and reproducibly within ±1 μm. Successful tests of this ID prototype led to the design of a 3-m long device based on the same concept. The 3-m long prototype is currently under construction. It represents R and D efforts by the APS toward APS Upgrade Project goals as well as the future generation of IDs for the Linac Coherent Light Source (LCLS)« less

Application of Atmospheric-Pressure Microwave Line Plasma for Low Temperature Process

NASA Astrophysics Data System (ADS)

Suzuki, Haruka; Nakano, Suguru; Itoh, Hitoshi; Sekine, Makoto; Hori, Masaru; Toyoda, Hirotaka

2015-09-01

Atmospheric pressure (AP) plasmas have been given much attention because of its high cost benefit and a variety of possibilities for industrial applications. In various kinds of plasma production technique, pulsed-microwave discharge plasma using slot antenna is attractive due to its ability of high-density and stable plasma production. In this plasma source, however, size of the plasma has been limited up to a few cm in length due to standing wave inside a waveguide. To solve this, we have proposed a newly-developed AP microwave plasma source that utilizes not standing wave but travelling wave. By using this plasma source, spatially-uniform AP line plasma with 40 cm in length was realized by pure helium discharge in 60 cm slot and with nitrogen gas additive of 1%. Furthermore, gas temperature as low as 400 K was realized in this device. In this study, as an example of low temperature processes, hydrophilic treatment of PET films was performed. Processing speed increased with pulse frequency and a water contact angle of ~20° was easily obtained within 5 s with no thermal damage to the substrate. To evaluate treatment-uniformity of long line length, PET films were treated by 90 cm slot-antenna plasma and uniform treatment performance was confirmed.

Anti-pertussis antibody kinetics following DTaP-IPV booster vaccination in Norwegian children 7-8 years of age.

PubMed

Aase, Audun; Herstad, Tove Karin; Jørgensen, Silje Bakken; Leegaard, Truls Michael; Berbers, Guy; Steinbakk, Martin; Aaberge, Ingeborg

2014-10-14

At the age of 7-8 years a booster of diphtheria, tetanus, acellular pertussis and polio vaccine is recommended for children in Norway. In this cross-sectional study we have analysed the antibody levels against pertussis vaccine antigens in sera from 498 children aged 6-12 years. The purposes of this study were to investigate the duration of the booster response against the pertussis vaccine antigens pertussis toxin (PT) and filamentous haemagglutinin (FHA); to determine the presence of high levels of pertussis antibodies in absence of recent vaccination; and to analyse how booster immunisation may interfere with the serological pertussis diagnostics. Prior to the booster the IgG antibody levels against PT revealed a geometric mean of 7.3IU/ml. After the booster the geometric mean peak anti-PT IgG response reached to 45.6IU/ml, followed by a steady decline in antibody levels over the next few years. The IgG anti-FHA levels followed the anti-PT IgG profiles. Three years after the booster the geometric mean IgG levels were only slightly above pre-booster levels. Prior to the booster 44% of the sera contained ≤5IU/ml of anti-PT IgG compared to18% 3 years after and 30% 4 years after the booster. When recently vaccinated children were excluded, 6.2% of the children had anti-PT IgG levels above 50IU/ml which may indicate pertussis infection within the last 2 years. This study indicates that the currently used acellular pertussis vaccines induce moderate immune responses to the pertussis antigens and that the antibodies wane within few years after the booster. This lack of sustained immune response may partly be responsible for the increased number of pertussis cases observed in this age group during the last years. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Prevalence and predictors of booster seat use in Alberta, Canada.

PubMed

Golonka, Richard P; Dobbs, Bonnie M; Rowe, Brian H; Voaklander, Don

2016-08-15

To determine the prevalence of booster seat misuse in a Canadian province and identify determinants of non-use. A cross-sectional study using parking lot interviews and in-vehicle restraint inspections by trained staff was conducted at 67 randomly selected childcare centres across Alberta. Only booster-eligible children were included in this analysis. Odds ratios (OR) and 95% confidence intervals (CI) are reported using unadjusted and adjusted logistic regression. Overall, 23% of children were not in a booster seat, and in 31.8% of cases there was evidence of at least one misuse. Non-use increased significantly by age, from 22.2% for children 2 years of age to 47.8% for children 7 years of age (p = 0.02). Children who were at significantly increased risk of booster seat non-use were those in vehicles with drivers who could not recall the booster seat to seatbelt transition point (OR: 4.54; 95% CI: 2.05-10.06) or drivers who were under the age of 30 (OR: 3.54; 95% CI: 1.45-8.62). A front row seating position was also associated with significantly higher risk of nonuse (OR: 18.00; 95% CI: 2.78-116.56). Children in vehicles with grandparent drivers exhibited significantly decreased risk of booster seat non-use (OR: 0.21; 95% CI: 0.05-0.85). Messaging should continue to stress that the front seat is not a safe place for any child under the age of 9 as well as remind drivers of the booster seat to seatbelt transition point, with additional emphasis placed on appealing to parents under the age of 30. Future research should focus on the most effective means of communicating booster seat information to this group. Enacting mandatory booster seat legislation would be an important step to increase both awareness and proper use of booster seats in Alberta.

Different Dynamics for IgG and IgA Memory B Cells in Adolescents following a Meningococcal Serogroup C Tetanus Toxoid Conjugate Booster Vaccination Nine Years after Priming: A Role for Priming Age?

PubMed Central

Stoof, Susanne P.; Buisman, Anne-Marie; van Rooijen, Debbie M.; Boonacker, Rianne; van der Klis, Fiona R. M.; Sanders, Elisabeth A. M.; Berbers, Guy A. M.

2015-01-01

Background Antibody levels wane rapidly after Meningococcal serogroup C conjugate (MenCC) vaccination in young children, rendering the need for an adolescent booster dose. It is not clear whether circulating memory B cells are associated with persistence of MenC-specific antibody levels. Methods Measurement of MenC-specific IgG and IgA memory B cells and levels of serum and salivary MenC-specific IgG and IgA in healthy 10-, 12- and 15-year-olds prior to and one month and one year after a MenCC booster vaccination. All participants had received a primary MenCC vaccination nine years earlier. Results The number of circulating MenC-specific IgG memory B cells prior to booster was low and not predictive for MenC-specific IgG responses in serum or saliva post-booster, whereas the number of MenC-specific IgA memory B cells pre-booster positively correlated with MenC-specific IgA levels in saliva post-booster (R = 0.5, P<0.05). The booster induced a clear increase in the number of MenC-specific IgG and IgA memory B cells. The number of MenC-PS-specific IgG memory B cells at 1 month post-booster was highest in the 12-year-olds. The number of MenC-specific memory B cells at one month post-booster showed no correlation with the rate of MenC-specific antibody decay throughout the first year post-booster. Conclusions Circulating MenC-specific IgA memory B cells correlate with IgA responses in saliva, whereas circulating MenC-specific IgG memory B cells are not predictive for MenC-specific IgG responses in serum or saliva. Our results are suggestive for age-dependent differences in pre-existing memory against MenC. PMID:26458006

Different Dynamics for IgG and IgA Memory B Cells in Adolescents following a Meningococcal Serogroup C Tetanus Toxoid Conjugate Booster Vaccination Nine Years after Priming: A Role for Priming Age?

PubMed

Stoof, Susanne P; Buisman, Anne-Marie; van Rooijen, Debbie M; Boonacker, Rianne; van der Klis, Fiona R M; Sanders, Elisabeth A M; Berbers, Guy A M

2015-01-01

Antibody levels wane rapidly after Meningococcal serogroup C conjugate (MenCC) vaccination in young children, rendering the need for an adolescent booster dose. It is not clear whether circulating memory B cells are associated with persistence of MenC-specific antibody levels. Measurement of MenC-specific IgG and IgA memory B cells and levels of serum and salivary MenC-specific IgG and IgA in healthy 10-, 12- and 15-year-olds prior to and one month and one year after a MenCC booster vaccination. All participants had received a primary MenCC vaccination nine years earlier. The number of circulating MenC-specific IgG memory B cells prior to booster was low and not predictive for MenC-specific IgG responses in serum or saliva post-booster, whereas the number of MenC-specific IgA memory B cells pre-booster positively correlated with MenC-specific IgA levels in saliva post-booster (R = 0.5, P<0.05). The booster induced a clear increase in the number of MenC-specific IgG and IgA memory B cells. The number of MenC-PS-specific IgG memory B cells at 1 month post-booster was highest in the 12-year-olds. The number of MenC-specific memory B cells at one month post-booster showed no correlation with the rate of MenC-specific antibody decay throughout the first year post-booster. Circulating MenC-specific IgA memory B cells correlate with IgA responses in saliva, whereas circulating MenC-specific IgG memory B cells are not predictive for MenC-specific IgG responses in serum or saliva. Our results are suggestive for age-dependent differences in pre-existing memory against MenC.

47 CFR 74.1281 - Station records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FM Broadcast Booster Stations § 74.1281 Station records. (a) The licensee of a station authorized... booster, except that the station records of a booster or translator licensed to the licensee of the...

47 CFR 74.1281 - Station records.

Code of Federal Regulations, 2012 CFR

2012-10-01

... FM Broadcast Booster Stations § 74.1281 Station records. (a) The licensee of a station authorized... booster, except that the station records of a booster or translator licensed to the licensee of the...

47 CFR 74.1281 - Station records.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FM Broadcast Booster Stations § 74.1281 Station records. (a) The licensee of a station authorized... booster, except that the station records of a booster or translator licensed to the licensee of the...

47 CFR 74.1281 - Station records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... FM Broadcast Booster Stations § 74.1281 Station records. (a) The licensee of a station authorized... booster, except that the station records of a booster or translator licensed to the licensee of the...

Planar concentrators near the étendue limit.

PubMed

Winston, Roland; Gordon, Jeffrey M

2005-10-01

Recently proposed aplanatic imaging designs are integrally combined with nonimaging flux boosters to produce an ultracompact planar glass-filled concentrator that performs near the étendue limit. Such optical devices are attractive for high-efficiency multijunction photovoltaics at high flux, with realistic power generation of 1 W from a 1 mm2 cell. When deployed in reverse, our designs provide collimation even for high-numerical-aperture light sources.

Planar concentrators near the étendue limit

NASA Astrophysics Data System (ADS)

Winston, Roland; Gordon, Jeffrey M.

2005-10-01

Recently proposed aplanatic imaging designs are integrally combined with nonimaging flux boosters to produce an ultracompact planar glass-filled concentrator that performs near the étendue limit. Such optical devices are attractive for high-efficiency multijunction photovoltaics at high flux, with realistic power generation of 1 W from a 1 mm² cell. When deployed in reverse, our designs provide collimation even for high-numerical-aperture light sources.

Advanced Integrated Multi-sensor Surveillance (AIMS). Mission, Function, Task Analysis

DTIC Science & Technology

2007-06-01

flaps, elevators and rudder control surfaces are based on conventional mechanical systems, using dual hydraulic boosters. Trim tabs are provided for... dumping the solid waste overboard it is difficult to determine its source. When an oil slick has been detected, the crew attempts to discover the...NAVCOM advises helicopter of on-scene weather, elevation, flight conditions and salient terrain features which may impact hoisting requirements

Booster Seat Effectiveness Among Older Children: Evidence From Washington State.

PubMed

Anderson, D Mark; Carlson, Lindsay L; Rees, Daniel I

2017-08-01

The American Academy of Pediatrics has recommended that children as old as 12 years use a booster seat when riding in motor vehicles, yet little is known about booster seat effectiveness when used by older children. This study estimated the association between booster use and injuries among children aged 8-12 years who were involved in motor vehicle crashes. Researchers analyzed data on all motor vehicle crashes involving children aged 8-12 years reported to the Washington State Department of Transportation from 2002 to 2015. Data were collected in 2015 and analyzed in 2016. Children who were in a booster seat were compared with children restrained by a seat belt alone. Logistic regression was used to adjust for potential confounders. In unadjusted models, booster use was associated with a 29% reduction in the odds of experiencing any injury versus riding in a seat belt alone (OR=0.709, 95% CI=0.675, 0.745). In models adjusted for potential confounders, booster use was associated with a 19% reduction in the odds of any injury relative to riding in a seat belt alone (OR=0.814, 95% CI=0.749, 0.884). The risk of experiencing an incapacitating/fatal injury was not associated with booster use. Children aged 8-12 years involved in a motor vehicle crash are less likely to be injured if in a booster than if restrained by a seat belt alone. Because only 10% of U.S. children aged 8-12 years use booster seats, policies encouraging their use could lead to fewer injuries. Copyright © 2017 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Lessons learned for follow-up phone booster counseling calls with substance abusing emergency department patients.

PubMed

Donovan, Dennis M; Hatch-Maillette, Mary A; Phares, Melissa M; McGarry, Ernest; Peavy, K Michelle; Taborsky, Julie

2015-03-01

Post-visit "booster" sessions have been recommended to augment the impact of brief interventions delivered in the emergency department (ED). This paper, which focuses on implementation issues, presents descriptive information and interventionists' qualitative perspectives on providing brief interventions over the phone, challenges, "lessons learned", and recommendations for others attempting to implement adjunctive booster calls. Attempts were made to complete two 20-minute telephone "booster" calls within a week following a patient's ED discharge with 425 patients who screened positive for and had recent problematic substance use other than alcohol or nicotine. Over half (56.2%) of participants completed the initial call; 66.9% of those who received the initial call also completed the second call. Median number of attempts to successfully contact participants for the first and second calls were 4 and 3, respectively. Each completed call lasted an average of about 22 minutes. Common challenges/barriers identified by booster callers included unstable housing, limited phone access, unavailability due to additional treatment, lack of compensation for booster calls, and booster calls coming from an area code different than the participants' locale and from someone other than ED staff. Specific recommendations are presented with respect to implementing a successful centralized adjunctive booster call system. Future use of booster calls might be informed by research on contingency management (e.g., incentivizing call completions), smoking cessation quitlines, and phone-based continuing care for substance abuse patients. Future research needs to evaluate the incremental benefit of adjunctive booster calls on outcomes over and above that of brief motivational interventions delivered in the ED setting. Copyright © 2015 Elsevier Inc. All rights reserved.

Shuttle Upgrade Using 5-Segment Booster (FSB)

NASA Technical Reports Server (NTRS)

Sauvageau, Donald R.; Huppi, Hal D.; McCool, A. A. (Technical Monitor)

2000-01-01

In support of NASA's continuing effort to improve the over-all safety and reliability of the Shuttle system- a 5-segment booster (FSB) has been identified as an approach to satisfy that overall objective. To assess the feasibility of a 5-segment booster approach, NASA issued a feasibility study contract to evaluate the potential of a 5-segment booster to improve the overall capability of the Shuttle system, especially evaluating the potential to increase the system reliability and safety. In order to effectively evaluate the feasibility of the 5-segment concept, a four-member contractor team was established under the direction of NASA Marshall Space Flight Center (MSFC). MSFC provided the overall program oversight and integration as well as program contractual management. The contractor team consisted of Thiokol, Boeing North American Huntington Beach (BNA), Lockheed Martin Michoud Space Systems (LMMSS) and United Space Alliance (USA) and their subcontractor bd Systems (Control Dynamics Division, Huntsville, AL). United Space Alliance included the former members of United Space Booster Incorporated (USBI) who managed the booster element portion of the current Shuttle solid rocket boosters. Thiokol was responsible for the overall integration and coordination of the contractor team across all of the booster elements. They were also responsible for all of the motor modification evaluations. Boeing North American (BNA) was responsible for all systems integration analyses, generation of loads and environments. and performance and abort mode capabilities. Lockheed Martin Michoud Space Systems (LMMSS) was responsible for evaluating the impacts of any changes to the booster on the external tank (ET), and evaluating any design changes on the external tank necessary to accommodate the FSB. USA. including the former USBI contingent. was responsible for evaluating any modifications to facilities at the launch site as well as any booster component design modifications.

[Current data on atmospheric pollutions].

PubMed

Festy, B; Petit-Coviaux, F; Le Moullec, Y

1991-01-01

Atmospheric pollutions (AP) are very important for human health and ecological equilibrium. They may be natural or anthropogenic and in this later case they can appear outdoor or indoor. Urban air pollution is the most known form of AP. Its main sources are industries, individual and collective heating and now mainly automobile traffic in most cities. Classical AP indicators are SO2, particles, NOx, CO and Pb measured in networks. Important factors of AP are amounts of pollutants emitted and local climatic and meteorological characteristics. Health effects of AP peaks and of AP background levels are not well known. But generally, mean AP levels of SO2 and particles decreased in the last years in most towns as the consequence of collective actions on the three main sources of AP and on fuels, emission and immission levels; but more is wanted about motor-cars. Progress are necessary for limitation of three major ecological risks: "acid-rain" (SO2 and NOx derivatives, ozone,...) which participates in lake and forest attacks; "green house" effects whose air CO2 concentration increase is the main responsible, and stratospheric ozone depletion mainly due to freons (CFC); the consequences of these two last phenomena are not well known but ecological and health risk exist. Besides, indoor air pollution (IAP) is very important because we live more than 20 h a day indoor. IAP may be occupational (a lot of chemical or biological agents) or not. In the later case air pollutants are very various: CO, NOx and particles from heating or cooking, formaldehyde from wood glue, plywood or urea-formol foams, radon and derivatives in some granitic countries, odd jobs products, cosmetics, aero-allergens of chemical or biological origins, microbes,... Environmental tobacco smoke (ETS) is also an important pollutant complex. Risks of IAP are real or potential: acute risk is obvious for CO, aero-allergens, formaldehyde, NOx,...); irritations are produced by ETS, formaldehyde, solvants,...; long term or potential risks are of concern for asbest, radon,... A complex and bad known pathology is described in a lot of modern buildings as the "Sick Building Syndrom". Indoor air quality is very dependant of the quality of ventilation and possible air treatment. It may be considered in all urban epidemiological studies about air pollution.

Superconducting racetrack booster for the ion complex of MEIC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Filatov, Yu; Kondratenko, A. M.; Kondratenko, M. A.

2016-02-01

The current design of the Medium-energy Electron-Ion Collider (MEIC) project at Jefferson lab features a single 8 GeV/c figure-8 booster based on super-ferric magnets. Reducing the circumference of the booster by switching to a racetrack design may improve its performance by limiting the space charge effect and lower its cost. We consider problems of preserving proton and deuteron polarizations in a superconducting racetrack booster. We show that using magnets based on hollow high-current NbTi composite superconducting cable similar to those designed at JINR for the Nuclotron guarantees preservation of the ion polarization in a racetrack booster up to 8 GeV/c.more » The booster operation cycle would be a few seconds that would improve the operating efficiency of the MEIC ion complex.« less

40 CFR 74.44 - Reduced utilization for combustion sources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... for consumption or in the residence or facility of a customer to whom the opt-in source's utility... production, the designated representative of the opt-in source must demonstrate to the satisfaction of the...: ER04AP95.014 where “actual heat input” and “reduction from improved efficiency” are defined as set forth in...

76 FR 66886 - Oil and Natural Gas Sector: New Source Performance Standards and National Emission Standards for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

...-AP76 Oil and Natural Gas Sector: New Source Performance Standards and National Emission Standards for... and Natural Gas Sector: New Source Performance Standards and National Emission Standards for Hazardous... be charged for copying. World Wide Web. The EPA Web site for this rulemaking is located at: http...

Anti-skin-aging benefits of exopolymers from Aureobasidium pullulans SM2001.

PubMed

Kim, Kyung Hu; Park, Soo Jin; Lee, Ji Eun; Lee, Young Joon; Song, Chang Hyun; Choi, Seong Hun; Ku, Sae Kwang; Kang, Su Jin

2014-01-01

There have been many attempts to search for affordable and effective functional cosmetic ingredients, especially from natural sources. As research into developing a functional cosmetic ingredient, we investigated whether exopolymers from Aureobasidium pullulans SM2001 (E-AP-SM2001) exert antioxidant, antiwrinkle, whitening, and skin moisturizing effects. Antioxidant effects of E-AP-SM2001 were determined by measuring free radical scavenging capacity and superoxide dismutase (SOD)-like activity. Antiwrinkle effects were assessed through the inhibition of hyaluronidase, elastase, collagenase, and matrix metalloproteinase (MMP)-1. Whitening effects were measured by tyrosinase inhibition assay, and by melanin formation test in B16/F10 melanoma cells. Skin moisturizing effects were detected by mouse skin water content test. E-AP-SM2001 showed potent DPPH radical scavenging activity and SOD-like effects. Additionally, hyaluronidase, elastase, collagenase, and MMP-1 activities were significantly inhibited by E-AP-SM2001. We also observed that E-AP-SM2001 effectively reduced melanin production by B16/F10 melanoma cells and mushroom tyrosinase activities. Furthermore, significant increases in skin water content were detected in E-AP-SM2001- treated mouse skin, as compared with vehicle-treated control skin. Notably, a mask pack containing E-AP-SM2001 showed a >twofold more extensive moisturizing effect compared with one containing Saccharomycopsis ferment filtrate. Our results suggest that E-AP-SM2001 has adequate antiaging, antiwrinkle, and whitening benefits and skin moisturizing effect. These effects involve reducing hyaluronidase, elastase, collagenase, and MMP-1 activities, as well as inhibition of melanin production and tyrosinase activities. Therefore, the antioxidant E-AP-SM2001 may serve as a predictable functional ingredient.

Comparison of Spectral and Scintillation Properties of LuAP:Ce and LuAP:Ce,Sc Single Crystals

NASA Astrophysics Data System (ADS)

Petrosyan, Ashot G.; Derdzyan, Marina; Ovanesyan, Karine; Shirinyan, Grigori; Lecoq, Paul; Auffray, Etiennette; Kronberger, Matthias; Frisch, Benjamin; Pedrini, Christian; Dujardin, Christophe

2009-10-01

Scintillation properties of LuAP:Ce and LuAP:Ce,Sc crystal series were studied under excitation by gamma-rays from a 137Cs source. Both series demonstrated comparable optical quality in terms of underlying absorption at 260 nm, slope of the optical edge and transmission in the range of emission. The light yield of LuAP:Ce crystals measured in 0.2 cm times 0.2 cm times 0.8 cm pixels increases linearly with the Ce concentration reaching at 0.58 at. % 6448 plusmn 322 ph/MeV and 9911 plusmn 496 ph/MeV in the long and in the short directions respectively (the light yield ratio is 65%) and shows no sign of light saturation. The energy resolution is found to depend, among other factors, on the uniformity of Ce concentration within the pixels and is improved to 7.1 plusmn 0.4% (I = 0.2 cm), 9.5 plusmn 0.5% (I = 0.8 cm). Intentional co-doping with Sc + ions was tested and resulted in increase of the Ce distribution coefficient to about 0.3. This enabled to increase the concentration of Ce in LuAP:Ce,Sc crystals up to 0.7 at. %, while conserving high optical quality. In contrast to LuAP:Ce, the light yield in LuAP:Ce,Sc crystals does not increase with Ce concentration, the photo peak being gradually suppressed. The involved mechanisms are discussed basing on measurements of the unit cell volumes, Ce concentration uniformity, x-ray rocking spectra, absorption spectra of pure and variously doped LuAP crystals, and emission spectra under different excitations.

[Seroprevalence of pertussis toxin antibody in Manisa province of Turkey, after six years implementation of acellular pertussis vaccine].

PubMed

Özbek, Özgen Alpay; Öktem, İbrahim Mehmet Ali; Hekimoğlu, Can Hüseyin; Sekreter, Özgür; Emek, Mestan; Atasoylu, Gonca; Açıkgöz, Ayla; Demirpençe, Nur; Ceylan, Ali; Baykal, Elif Sanem; Ünal, Belgin

2018-04-01

Vaccination is the most effective way of preventing pertussis disease. Turkey commenced a routine infant immunization program using whole cell (wP) pertussis vaccine in 1968. Immunization accelerated in 1985 after participation of Turkey in the Expanded Programme on Immunization initiated by the World Health Organization. Acellular vaccine (aP) replaced wP in 2008 and a booster was added to age 6 in 2010. The immunization programme was successful in reducing the morbidity rate from 20.58 per 100.000 in 1970 to the lowest level of 0.01 per 100.000 in 2009. However, reduction of vaccine-induced protection and reduced natural boosting of circulating Bordetella pertussis are likely to increase the susceptibility of the population. As a result, morbidity rate increased from 0.09 per 100.000 to 0.41 per 100.000 in 2015 compared to the previous year. The aim of this epidemiological study was to determine the seroprevalence of pertussis toxin (PT) antibodies among healthy people and its association with various social determinants in Manisa province in Turkey, 6 years after aP replaced wP vaccine. The study was conducted as a cross-sectional study with a sample of 1250 people that was randomly selected from the over 2 years of age population in Manisa in 2014. Seroprevalence of PT antibody was determined as the dependent variable of the study. Independent variables of the study were; gender, age, migration in the last 5 years, occupational class, perceived income, house ownership, number of people per room, annually per capita equivalent income. The presence of anti-PT IgG was detected by quantitatively using a commercially available ELISA kit. The antibody levels were categorized into groups according to pertussis infection or vaccination immune response status. The groups consisted of undetectable (< 5 IU/ml), mid-range (5-< 62.5 IU/ml: more than one year previously), high (62.5-< 125: with in 12 months) and very high (≥ 125 IU/ml: with in 6 months) antibody levels. The test results with ≥ 5 IU/ml were defined as seropositive. Level > 100 IU/ml detected among adolescent and adult participants indicated acute or recently recovered pertussis infection. Chi-square test was used to evaluate association between social determinants and pertussis seropositivity. The seroprevalence of the whole study population was 58.1% (95% CI 55.32-60.79) and no association was found with any of the social determinants. The highest seroprevalence was found among 2-9 age group (68.3%) followed by 70-79 age group (63.5%). The lowest seroprevalence was found among 20-29 age group (50.9%) followed by 10-19 age group (51.6%). When seropositivity levels according to ages were compared, it was found that there was a decrease one year after the first vaccination at 2nd, 4th and 6th months and the booster at the 6th year, with a lowest rate (19%) in 11 year-old. The highest seropositivity (77.3%) with a level of >100 IU/ml (13.6%) were detected at age 15 among all adolescent and adult participants. Adding an adolescent booster to immunization schedule and recommendation of vaccine to elderly people should be considered to reduce the incidence of pertussis disease in Turkey.

News Resources on the World Wide Web.

ERIC Educational Resources Information Center

Notess, Greg R.

1996-01-01

Describes up-to-date news sources that are presently available on the Internet and World Wide Web. Highlights include electronic newspapers; AP (Associated Press) sources and Reuters; sports news; stock market information; New York Times; multimedia capabilities, including CNN Interactive; and local and regional news. (LRW)

SRB Processing Facilities Media Event

NASA Image and Video Library

2016-03-01

The right-hand aft skirt, one part of the aft booster assembly for NASA’s Space Launch System solid rocket boosters, is in view in a processing cell inside the Booster Fabrication Facility (BFF) at NASA’s Kennedy Space Center in Florida. Orbital ATK is a contractor for NASA’s Marshall Space Flight Center in Alabama, and operates the BFF to prepare aft booster segments and hardware for the SLS rocket boosters. The SLS rocket and Orion spacecraft will launch on Exploration Mission-1 in 2018. The Ground Systems Development and Operations Program is preparing the infrastructure to process and launch spacecraft for deep-space missions and the journey to Mars.

Viscoelastic propellant effects on Space Shuttle Dynamics

NASA Technical Reports Server (NTRS)

Bugg, F.

1981-01-01

The program of solid propellant research performed in support of the space shuttle dynamics modeling effort is described. Stiffness, damping, and compressibility of the propellant and the effects of many variables on these properties are discussed. The relationship between the propellant and solid rocket booster dynamics during liftoff and boost flight conditions and the effects of booster vibration and propellant stiffness on free free solid rocket booster modes are described. Coupled modes of the shuttle system and the effect of propellant stiffness on the interfaces of the booster and the external tank are described. A finite shell model of the solid rocket booster was developed.

Launch Architecture Impact on Ascent Abort and Crew Survival

NASA Technical Reports Server (NTRS)

Mathias, Donovan L.; Lawrence, Scott L.

2006-01-01

A study was performed to assess the effect of booster configuration on the ascent abort process. A generic abort event sequence was created and booster related risk drivers were identified. Three model boosters were considered in light of the risk drivers: a solid rocket motor configuration, a side mount combination solid and liquid configuration, and a stacked liquid configuration. The primary risk drivers included explosive fireball, overpressure, and fragment effects and booster-crew module re-contact. Risk drivers that were not specifically booster dependent were not addressed. The solid rocket configuration had the most benign influence on an abort while the side mount architecture provided the most challenging abort environment.

A simple process based on NH2- and CH3-terminated monolayers for low contact resistance and adherent Au electrode in bottom-contact OTFTs

NASA Astrophysics Data System (ADS)

Abdur, Rahim; Lim, Jeongeun; Jeong, Kyunghoon; Rahman, Mohammad Arifur; Kim, Jiyoung; Lee, Jaegab

2016-03-01

An efficient process for the low contact resistance and adherent source/drain Au electrode in bottom-contact organic thin film transistors (OTFTs) was developed. This was achieved by using two different surface-functional groups of self-assembled monolayers, 3-aminopropyltriethoxysilane (APS), and octadecyltrichlorosilane (OTS), combined with atmospheric-pressure (AP) plasma treatment. Prior to the deposition of Au electrode, the aminoterminated monolayer self-assembles on SiO2 dielectrics, enhancing the adhesion of Au electrode as a result of the acid-base interaction of Au with the amino-terminal groups. AP plasma treatment of the patterned Au electrode on the APS-coated surface activates the entire surface to form an OTS monolayer, allowing the formation of a high quality pentacene layer on both the electrode and active region by evaporation. In addition, negligible damage by AP plasma was observed for the device performance. The fabricated OTFTs based on the two monolayers by AP plasma treatment showed the mobility of 0.23 cm2/Vs, contact resistance of 29 kΩ-cm, threshold voltage of -1.63 V, and on/off ratio of 9.8 × 105, demonstrating the application of the simple process for robust and high-performance OTFTs. [Figure not available: see fulltext.

Space shuttle phase B wind tunnel model and test information. Volume 1: Booster configuration

NASA Technical Reports Server (NTRS)

Glynn, J. L.; Poucher, D. E.

1988-01-01

Archived wind tunnel test data are available for flyback booster or other alternative recoverable configurations as well as reusable orbiters studied during initial development (Phase B) of the Space Shuttle. Considerable wind tunnel data was acquired by the competing contractors and the NASA Centers for an extensive variety of configurations with an array of wing and body planforms. All contractor and NASA wind tunnel test data acquired in the Phase B development have been compiled into a database and are available for application to current winged flyback or recoverable booster aerodynamic studies. The Space Shuttle Phase B Wind Tunnel Database is structured by vehicle component and configuration type. Basic components include the booster, the orbiter, and the launch vehicle. Booster configuration types include straight and delta wings, canard, cylindrical, retroglide and twin body. Orbiter configuration types include straight and delta wings, lifting body, drop tanks and double delta wings. Launch configurations include booster and orbiter components in various stacked and tandem combinations. This is Volume 1 (Part 2) of the report -- Booster Configuration.

Space shuttle phase B wind tunnel model and test information. Volume 1: Booster configuration

NASA Technical Reports Server (NTRS)

Glynn, J. L.; Poucher, D. E.

1988-01-01

Archived wind tunnel test data are available for flyback booster or other alternative recoverable configurations as well as reusable orbiters studied during initial development (Phase B) of the Space Shuttle. Considerable wind tunnel data was acquired by the competing contractors and the NASA Centers for an extensive variety of configurations with an array of wing and body planforms. All contractor and NASA wind tunnel test data acquired in the Phase B development have been compiled into a database and are available for application to current winged flyback or recoverable booster aerodynamic studies. The Space Shuttle Phase B Wind Tunnel Database is structured by vehicle component and configuration type. Basic components include the booster, the orbiter and the launch vehicle. Booster configuration types include straight and delta wings, canard, cylindrical, retroglide and twin body. Orbiter configuration types include straight and delta wings, lifting body, drop tanks, and double delta wings. Launch configurations include booster and orbiter components in various stacked and tandem combinations. This is Volume 1 (Part 1) of the report -- Booster Configuration.

Did two booster doses for schoolchildren change the epidemiology of pertussis in Israel?

PubMed

Anis, Emilia; Moerman, Larisa; Ginsberg, Gary; Karakis, Isabella; Slater, Paul E; Warshavsky, Bruce; Gosinov, Ruslan; Grotto, Itamar; Marva, Esther

2018-05-28

Pertussis is the only vaccine-preventable disease that has re-emerged in Israel. In the last two decades, despite high primary immunization coverage, crude incidence increased over tenfold, with especially high morbidity among infants and adolescents and with 19 infant deaths. Two pertussis vaccine boosters were added, in 2005 for 7-year-olds and in 2011 for 13-year-olds. We reviewed age group incidence from 1999 to 2016, before and after the booster program introduction. We compared three groups of 13-15 year-olds with identical primary immunization but different booster immunization histories. Vaccine effectiveness was calculated before and after adjustment for specific incidence in those aged 65 and over. Two years after one booster, adjusted vaccine effectiveness was 74.5%. Two years after two boosters, adjusted vaccine effectiveness was 91.8%. However, crude morbidity rates were not reduced. The booster program has been effective only among recipient groups. The program will be continued. Israel is now encouraging pregnant women to be vaccinated against pertussis to improve protection of infants.

Perpendicular Biased Ferrite Tuned Cavities for the Fermilab Booster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romanov, Gennady; Awida, Mohamed; Khabiboulline, Timergali

2014-07-01

The aging Fermilab Booster RF system needs an upgrade to support future experimental program. The important feature of the upgrade is substantial enhancement of the requirements for the accelerating cavities. The new requirements include enlargement of the cavity beam pipe aperture, increase of the cavity voltage and increase in the repetition rate. The modification of the present traditional parallel biased ferrite cavities is rather challenging. An alternative to rebuilding the present Fermilab Booster RF cavities is to design and construct new perpendicular biased RF cavities, which potentially offer a number of advantages. An evaluation and a preliminary design of themore » perpendicular biased ferrite tuned cavities for the Fermilab Booster upgrade is described in the paper. Also it is desirable for better Booster performance to improve the capture of beam in the Booster during injection and at the start of the ramp. One possible way to do that is to flatten the bucket by introducing second harmonic cavities into the Booster. This paper also looks into the option of using perpendicularly biased ferrite tuners for the second harmonic cavities.« less

Counterrotatable booster compressor assembly for a gas turbine engine

NASA Technical Reports Server (NTRS)

Moniz, Thomas Ory (Inventor); Orlando, Robert Joseph (Inventor)

2004-01-01

A counterrotatable booster compressor assembly for a gas turbine engine having a counterrotatable fan section with a first fan blade row connected to a first drive shaft and a second fan blade row axially spaced from the first fan blade row and connected to a second drive shaft, the counterrotatable booster compressor assembly including a first compressor blade row connected to the first drive shaft and a second compressor blade row interdigitated with the first compressor blade row and connected to the second drive shaft. A portion of each fan blade of the second fan blade row extends through a flowpath of the counterrotatable booster compressor so as to function as a compressor blade in the second compressor blade row. The counterrotatable booster compressor further includes a first platform member integral with each fan blade of the second fan blade row at a first location so as to form an inner flowpath for the counterrotatable booster compressor and a second platform member integral with each fan blade of the second fan blade row at a second location so as to form an outer flowpath for the counterrotatable booster compressor.

Status of the RF BPM upgrade at the Advanced Photon Source.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pietryla, A.; Bui, H.; Decker, G.

2008-01-01

The Advanced Photon Source (APS),a third-generation synchrotron light source, has been in operation for eleven years. The monopulse radio frequency (rf) beam position monitor (BPM) is one of three BPM types now employed in the storage ring at the APS. It is a broadband (10 MHz) system designed to measure single-turn and multi-turn beam positions, but it suffers from an aging data acquisition system. The replacement BPM system retains the existing monopulse receivers and replaces the data acquisition system with high-speed analog-to-digital converters (ADCs) and a field-programmable gate array (FPGA) that performs the signal processing. A first-article system has beenmore » constructed and is currently being evaluated. This paper presents the results of testing of the first-article system as well as the progress made in other areas of this upgrade effort.« less

1993 CAT workshop on beamline optical designs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-11-01

An Advanced Photon Source (APS) Collaborative Access Team (CAT) Workshop on Beamline Optical Designs was held at Argonne National Laboratory on July 26--27, 1993. The goal of this workshop was to bring together experts from various synchrotron sources to provide status reports on crystal, reflecting, and polarizing optics as a baseline for discussions of issues facing optical designers for CAT beamlines at the APS. Speakers from the European Synchrotron Radiation Facility (ESRF), the University of Chicago, the National Synchrotron Light Source, and the University of Manchester (England) described single- and double-crystal monochromators, mirrors, glass capillaries, and polarizing optics. Following thesemore » presentations, the 90 participants divided into three working groups: Crystal Optics Design, Reflecting Optics, and Optics for Polarization Studies. This volume contains copies of the presentation materials from all speakers, summaries of the three working groups, and a ``catalog`` of various monochromator designs.« less

Health in All Policies: From rhetoric to implementation and evaluation - the Finnish experience.

PubMed

Ståhl, Timo

2018-02-01

The principles of the Health in All Policies (HiAP) approach are not new. Their international roots can be traced back to 1978 and the Alma-Ata Declaration and the 1986 Ottawa Charter. In Finland, the roots of HiAP go back to 1972 when the Economic Council of Finland, chaired by the Prime Minister, launched the 'Report of the working group exploring the goals of health'. The paper discusses the history, rationale, and implementation of the principles underlying the umbrella concept of HiAP. A rationale for implementing a new concept - HiAP in 2006 during the Finnish European Union presidency - is given. The focus here will be on implementation of HiAP. International material supporting the implementation is introduced and practical examples from Finland presented. The Benchmarking System for Health Promotion Capacity Building is introduced, since it has been used as a primary source of information for monitoring and evaluating HiAP in Finland at the local level. The experience from Finland clearly indicates that HiAP as an approach and as a way of working requires long-term commitment and vision. For working across sectors it is crucial to have data on health and health determinants and analyses of the links between health outcomes, health determinants, and policies across sectors and levels of governance. Intersectoral structures, processes, and tools for the identification of problems and solutions, decisions, and implementation across sectors are prerequisites of HiAP. Legislative backing has proven to be useful, especially in providing continuation and sustainability.

Production and flux of carbohydrate species in the Gulf of Mexico

NASA Astrophysics Data System (ADS)

Hung, Chin-Chang; Guo, Laodong; Schultz, Gary E.; Pinckney, James L.; Santschi, Peter H.

2003-06-01

Carbohydrates are an important organic compound class in seawater and play an active role in the biogeochemical cycling of organic carbon and trace elements in the ocean, but are poorly characterized. To better understand the sources and role of carbohydrate species in marine environments, the concentrations and fluxes of particulate carbohydrates (CHO), total acid polysaccharides (APS), uronic acids (URA), phytoplankton composition and bacterial production were measured in the Gulf of Mexico in 2000 and 2001. A strong positive correlation between APS concentration and cyanobacteria abundance was found in 2000. In 2001, prymnesiophyte abundance correlated well with both concentrations of APS and URA. Bacterial production data, measured simultaneously in 2001, showed significant positive relationships with particulate organic carbon (POC), CHO, APS and URA concentrations, respectively. The average fluxes out of the euphotic zone of CHO, APS and URA in 2000 were 8.1, 1.3, and 0.7 mg C m-2 d-1, respectively. In 2001, the average fluxes of CHO, APS and URA were about 3 times higher than those in 2000, which was a time of lower nutrient concentrations, indicating that the fluxes of carbohydrate species are related to the nutrient status and phytoplankton composition. The results suggest that APS in the upper water column can be produced by cyanobacteria, prymnesiophytes, and heterotrophic bacteria. Most importantly, our data indicate that APS and CHO compounds are more resistant to biological degradation than other organic compounds, suggesting that the role of CHO compounds in carbon cycling in the ocean is more complex than previously thought.

Coherent optical transition radiation and self-amplified spontaneous emission generated by chicane-compressed electron beams

NASA Astrophysics Data System (ADS)

Lumpkin, A. H.; Dejus, R. J.; Sereno, N. S.

2009-04-01

Observations of strongly enhanced optical transition radiation (OTR) following significant bunch compression of photoinjector beams by a chicane have been reported during the commissioning of the Linac Coherent Light Source accelerator and recently at the Advanced Photon Source (APS) linac. These localized transverse spatial features involve signal enhancements of nearly a factor of 10 and 100 in the APS case at the 150-MeV and 375-MeV OTR stations, respectively. They are consistent with a coherent process seeded by noise and may be evidence of a longitudinal space charge microbunching instability which leads to coherent OTR emissions. Additionally, we suggest that localized transverse structure in the previous self-amplified spontaneous emission (SASE) free-electron laser (FEL) data at APS in the visible regime as reported at FEL02 may be attributed to such beam structure entering the FEL undulators and inducing the SASE startup at those “prebunched” structures. Separate beam structures 120 microns apart in x and 2.9 nm apart in wavelength were reported. The details of these observations and operational parameters will be presented.

X-ray Diffraction and Multi-Frame Phase Contrast Imaging Diagnostics for IMPULSE at the Advanced Photon Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iverson, Adam; Carlson, Carl; Young, Jason

2013-07-08

The diagnostic needs of any dynamic loading platform present unique technical challenges that must be addressed in order to accurately measure in situ material properties in an extreme environment. The IMPULSE platform (IMPact system for Ultrafast Synchrotron Experiments) at the Advanced Photon Source (APS) is no exception and, in fact, may be more challenging, as the imaging diagnostics must be synchronized to both the experiment and the 60 ps wide x-ray bunches produced at APS. The technical challenges of time-resolved x-ray diffraction imaging and high-resolution multi-frame phase contrast imaging (PCI) are described in this paper. Example data from recent IMPULSEmore » experiments are shown to illustrate the advances and evolution of these diagnostics with a focus on comparing the performance of two intensified CCD cameras and their suitability for multi-frame PCI. The continued development of these diagnostics is fundamentally important to IMPULSE and many other loading platforms and will benefit future facilities such as the Dynamic Compression Sector at APS and MaRIE at Los Alamos National Laboratory.« less

A genetically inactivated two-component acellular pertussis vaccine, alone or combined with tetanus and reduced-dose diphtheria vaccines, in adolescents: a phase 2/3, randomised controlled non-inferiority trial.

PubMed

Sricharoenchai, Sirintip; Sirivichayakul, Chukiat; Chokephaibulkit, Kulkanya; Pitisuttithum, Punnee; Dhitavat, Jittima; Pitisuthitham, Arom; Phongsamart, Wanatpreeya; Boonnak, Kobporn; Lapphra, Keswadee; Sabmee, Yupa; Wittawatmongkol, Orasri; Chinwangso, Pailinrut; Poredi, Indrajeet Kumar; Petre, Jean; Thai, Pham Hong; Viviani, Simonetta

2018-01-01

Increasing evidence shows that protection induced by acellular pertussis vaccines is short-lived, requiring repeated booster vaccination to control pertussis disease. We aimed to assess the safety and immunogenicity of a recombinant acellular pertussis vaccine containing genetically inactivated pertussis toxin and filamentous haemagglutinin, as either a monovalent vaccine (aP [PTgen/FHA] ) or in combination with tetanus and reduced-dose diphtheria vaccines (TdaP [PTgen/FHA] ), versus a licensed tetanus and reduced-dose diphtheria and acellular pertussis combination vaccine (Tdap). We did this phase 2/3, randomised controlled non-inferiority trial at two sites in Bangkok, Thailand. Healthy adolescents (aged 12-17 years) were randomly assigned (1:1:1), via a computer-generated randomisation list with block sizes of three, to receive one dose (0·5 mL) of aP (PTgen/FHA) , TdaP (PTgen/FHA) , or Tdap (comparator). Clinical research staff responsible for participant randomisation, vaccine preparation and administration, and accountability were aware of group allocation. However, allocation was concealed from all other site study staff, data management personnel, statisticians, laboratory staff, and study participants. The primary outcome was non-inferior immunogenicity of TdaP (PTgen/FHA) to Tdap based on seroconversion rates (a four-fold increase or more) for pertussis toxin and filamentous haemagglutinin IgG antibodies 28 days after vaccination, with a predefined 10% margin of equivalence. We did analysis by per protocol. This study is registered with the Thai Clinical Trial Registry, number TCTR20150703002. Between July 6 and Aug 20, 2015, we allocated 450 participants to receive one dose of TdaP (PTgen/FHA) (n=150), aP (PTgen/FHA) (n=150), or comparator Tdap (n=150). 28 days after vaccination, seroconversion rates for anti-pertussis toxin IgG were 96·6% (95% CI 93·8-99·5; n=144) in the TdaP (PTgen/FHA) group and 55·0% (47·1-63·0; n=82) in the comparator Tdap group (difference 41·6%, 95% CI 33·1-50·1; p<0·0001). Seroconversion rates for anti-filamentous haemagglutinin were 82·6% (95% CI 76·5-88·6; n=123) in the TdaP (PTgen/FHA) group and 54·4% (46·4-62·4; n=81) in the comparator group (difference 28·2%, 95% CI 18·1-38·2 p<0·0001). 28 days after vaccination, seroconversion rates in the aP (PTgen/FHA) group were 96·0% (95% CI 92·8-99·1; n=142) for anti-pertussis toxin IgG and 93·2% (89·2-97·3; n=138) for anti-filamentous haemagglutinin IgG. These findings support the non-inferior immunogenicity of TdaP (PTgen/FHA) over comparator Tdap. Reactogenicity and incidence of adverse events were similar between groups. The new TdaP (PTgen/FHA) vaccine is safe and induces higher pertussis responses 28 days after vaccination than does the available licensed Tdap booster vaccine. Results of our trial led to the licensure of new acellular pertussis vaccines containing genetically inactivated pertussis toxin in Thailand. The availability of recombinant monovalent pertussis vaccines that induce high antibody responses provides the medical community and consumers with the opportunity to vaccinate against pertussis when immunisation against diphtheria and tetanus is not required or not desired. Studies are underway to pave the way for licensure studies of this acellular pertussis vaccine in other countries. BioNet-Asia. Copyright © 2018 Elsevier Ltd. All rights reserved.

7. VIEW OF BOOSTER STATION 3, FACING NORTHWEST Nevada ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. VIEW OF BOOSTER STATION 3, FACING NORTHWEST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

2. VIEW OF BOOSTER STATION 1, FACING NORTHEAST Nevada ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW OF BOOSTER STATION 1, FACING NORTHEAST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

11. VIEW OF BOOSTER STATION 4, FACING SOUTHEAST Nevada ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. VIEW OF BOOSTER STATION 4, FACING SOUTHEAST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

10. VIEW OF BOOSTER STATION 4, FACING NORTHWEST Nevada ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. VIEW OF BOOSTER STATION 4, FACING NORTHWEST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

1. VIEW OF BOOSTER STATION 1, FACING SOUTHWEST Nevada ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW OF BOOSTER STATION 1, FACING SOUTHWEST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

8. VIEW OF BOOSTER STATION 3, FACING SOUTHEAST Nevada ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. VIEW OF BOOSTER STATION 3, FACING SOUTHEAST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

4. VIEW OF BOOSTER STATION 2, FACING NORTHWEST Nevada ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. VIEW OF BOOSTER STATION 2, FACING NORTHWEST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

5. VIEW OF BOOSTER STATION 2, FACING SOUTHEAST Nevada ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. VIEW OF BOOSTER STATION 2, FACING SOUTHEAST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

Space Shuttle Five-Segment Booster (Short Course)

NASA Technical Reports Server (NTRS)

Graves, Stanley R.; Rudolphi, Michael (Technical Monitor)

2002-01-01

NASA is considering upgrading the Space Shuttle by adding a fifth segment (FSB) to the current four-segment solid rocket booster. Course materials cover design and engineering issues related to the Reusable Solid Rocket Motor (RSRM) raised by the addition of a fifth segment to the rocket booster. Topics cover include: four segment vs. five segment booster, abort modes, FSB grain design, erosive burning, enhanced propellant burn rate, FSB erosive burning model development and hardware configuration.

KSC-2011-1836

NASA Image and Video Library

2011-02-26

CAPE CANAVERAL, Fla. -- Freedom Star, one of NASA's solid rocket booster retrieval ships, and its crew are preparing to recover the left spent booster from the Atlantic Ocean. The round objects on deck are large pumping machines that will be attached to the booster by a hose that will blow out debris and water and then pump in air so the booster can float horizontally on the water's surface for towing back to Port Canaveral in Florida. The shuttle’s two solid rocket booster casings and associated flight hardware are recovered in the Atlantic Ocean after every launch by Liberty Star and Freedom Star. The boosters impact the Atlantic about seven minutes after liftoff and the retrieval ships are stationed about 10 miles from the impact area at the time of splashdown. After the spent segments are processed, they will be transported to Utah, where they will be refurbished and stored, if needed. Photo credit: NASA/Ben Smegelsky

Clinical and economic assessment of different general population strategies of pertussis vaccine booster regarding number of doses and age of application for reducing whooping cough disease burden: a systematic review.

PubMed

Rodríguez-Cobo, Iria; Chen, Yen-Fu; Olowokure, Babatunde; Litchfield, Ian

2008-12-09

Pertussis continues to be an important cause of morbidity and mortality in children too young to be fully protected despite high vaccination coverage. This has been attributed to waning immunity in older people, leading to the development of strategies to increase levels of immunity. A systematic review was conducted to assess the clinical and cost effectiveness of four population-based strategies for pertussis booster vaccination: single booster at 12-24 months old, single pre-school booster, single adolescent booster and multiple boosters in adulthood every 10 years. Electronic databases and Internet resources were searched to June 2006. Nine observational studies, four mathematical models and eight economic evaluations were included, evaluating four different strategies. Strong evidence to recommend any of these strategies was not found.

Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults.

PubMed

Gillard, Paul; Chu, Daniel Wai Sing; Hwang, Shinn-Jang; Yang, Pan-Chyr; Thongcharoen, Prasert; Lim, Fong Seng; Dramé, Mamadou; Walravens, Karl; Roman, François

2014-03-15

The pandemic potential of avian influenza A/H5N1 should not be overlooked, and the continued development of vaccines against these highly pathogenic viruses is a public health priority. This open-label extension booster study followed a Phase III study of 1206 adults who had received two 3.75 μg doses of primary AS03A-adjuvanted or non-adjuvanted H5N1 split-virus vaccine (A/Vietnam/1194/2004; clade 1) (NCT00449670). The aim of the extension study was to evaluate different timings for heterologous AS03A-adjuvanted booster vaccination (A/Indonesia/5/2005; clade 2.1) given at Month 6, 12, or 36 post-primary vaccination. Immunogenicity was assessed 21 days after each booster vaccination and the persistence of immune responses against the primary vaccine strain (A/Vietnam) and the booster strain (A/Indonesia) was evaluated up to Month 48 post-primary vaccination. Reactogenicity and safety were also assessed. After booster vaccination given at Month 6, HI antibody responses to primary vaccine, and booster vaccine strains were markedly higher with one dose of AS03A-H5N1 booster vaccine in the AS03A-adjuvanted primary vaccine group compared with two doses of booster vaccine in the non-adjuvanted primary vaccine group. HI antibody responses were robust against the primary and booster vaccine strains 21 days after boosting at Month 12 or 36. At Month 48, in subjects boosted at Month 6, 12, or 36, HI antibody titers of ≥1:40 against the booster strain persisted in 39.2%, 61.2%, and 95.6% of subjects, respectively. Neutralizing antibody responses and cell-mediated immune responses also showed that AS03A-H5N1 heterologous booster vaccination elicited robust immune responses within 21 days of boosting at Month 6, 12, or 36 post-primary vaccination. The booster vaccine was well tolerated, and no safety concerns were raised. In Asian adults primed with two doses of AS03A-adjuvanted H5N1 pandemic influenza vaccine, strong cross-clade anamnestic antibody responses were observed after one dose of AS03A-H5N1 heterologous booster vaccine given at Month 6, 12, or 36 after priming, suggesting that AS03A-adjuvanted H5N1 vaccines may provide highly flexible prime-boost schedules. Although immunogenicity decreased with time, vaccinated populations could potentially be protected for up to three years after vaccination, which is likely to far exceed the peak of the a pandemic.

Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults

PubMed Central

2014-01-01

Background The pandemic potential of avian influenza A/H5N1 should not be overlooked, and the continued development of vaccines against these highly pathogenic viruses is a public health priority. Methods This open-label extension booster study followed a Phase III study of 1206 adults who had received two 3.75 μg doses of primary AS03A-adjuvanted or non-adjuvanted H5N1 split-virus vaccine (A/Vietnam/1194/2004; clade 1) (NCT00449670). The aim of the extension study was to evaluate different timings for heterologous AS03A-adjuvanted booster vaccination (A/Indonesia/5/2005; clade 2.1) given at Month 6, 12, or 36 post-primary vaccination. Immunogenicity was assessed 21 days after each booster vaccination and the persistence of immune responses against the primary vaccine strain (A/Vietnam) and the booster strain (A/Indonesia) was evaluated up to Month 48 post-primary vaccination. Reactogenicity and safety were also assessed. Results After booster vaccination given at Month 6, HI antibody responses to primary vaccine, and booster vaccine strains were markedly higher with one dose of AS03A-H5N1 booster vaccine in the AS03A-adjuvanted primary vaccine group compared with two doses of booster vaccine in the non-adjuvanted primary vaccine group. HI antibody responses were robust against the primary and booster vaccine strains 21 days after boosting at Month 12 or 36. At Month 48, in subjects boosted at Month 6, 12, or 36, HI antibody titers of ≥1:40 against the booster strain persisted in 39.2%, 61.2%, and 95.6% of subjects, respectively. Neutralizing antibody responses and cell-mediated immune responses also showed that AS03A-H5N1 heterologous booster vaccination elicited robust immune responses within 21 days of boosting at Month 6, 12, or 36 post-primary vaccination. The booster vaccine was well tolerated, and no safety concerns were raised. Conclusions In Asian adults primed with two doses of AS03A-adjuvanted H5N1 pandemic influenza vaccine, strong cross-clade anamnestic antibody responses were observed after one dose of AS03A-H5N1 heterologous booster vaccine given at Month 6, 12, or 36 after priming, suggesting that AS03A-adjuvanted H5N1 vaccines may provide highly flexible prime–boost schedules. Although immunogenicity decreased with time, vaccinated populations could potentially be protected for up to three years after vaccination, which is likely to far exceed the peak of the a pandemic. PMID:24628789

External amplification of OCT swept-sources for challenging applications: from 10 mW to more than 120 mW

NASA Astrophysics Data System (ADS)

Rivard, Maxime; Villeneuve, Alain; Lamouche, Guy

2017-02-01

For bioimaging applications, commercial swept-sources currently provide enough power (tens of milliwatts) insuring good imaging condition without damaging the tissues. For industrial applications, more power is needed since the amount of light collected can be very low due to challenging measurement conditions or due to poor sample reflectivity. To address this challenge, we explore three different setups to externally amplify the output of a commercial swept-source: a booster semiconductor optical amplifier (BOA), an erbium-doped fiber amplifier (EDFA) and a combination of both. These external amplification setups allow the exploration of emerging OCT applications without the need to develop new hardware.

The Chandra Source Catalog 2.0: Estimating Source Fluxes

NASA Astrophysics Data System (ADS)

Primini, Francis Anthony; Allen, Christopher E.; Miller, Joseph; Anderson, Craig S.; Budynkiewicz, Jamie A.; Burke, Douglas; Chen, Judy C.; Civano, Francesca Maria; D'Abrusco, Raffaele; Doe, Stephen M.; Evans, Ian N.; Evans, Janet D.; Fabbiano, Giuseppina; Gibbs, Danny G., II; Glotfelty, Kenny J.; Graessle, Dale E.; Grier, John D.; Hain, Roger; Hall, Diane M.; Harbo, Peter N.; Houck, John C.; Lauer, Jennifer L.; Laurino, Omar; Lee, Nicholas P.; Martínez-Galarza, Juan Rafael; McCollough, Michael L.; McDowell, Jonathan C.; McLaughlin, Warren; Morgan, Douglas L.; Mossman, Amy E.; Nguyen, Dan T.; Nichols, Joy S.; Nowak, Michael A.; Paxson, Charles; Plummer, David A.; Rots, Arnold H.; Siemiginowska, Aneta; Sundheim, Beth A.; Tibbetts, Michael; Van Stone, David W.; Zografou, Panagoula

2018-01-01

The Second Chandra Source Catalog (CSC2.0) will provide information on approximately 316,000 point or compact extended x-ray sources, derived from over 10,000 ACIS and HRC-I imaging observations available in the public archive at the end of 2014. As in the previous catalog release (CSC1.1), fluxes for these sources will be determined separately from source detection, using a Bayesian formalism that accounts for background, spatial resolution effects, and contamination from nearby sources. However, the CSC2.0 procedure differs from that used in CSC1.1 in three important aspects. First, for sources in crowded regions in which photometric apertures overlap, fluxes are determined jointly, using an extension of the CSC1.1 algorithm, as discussed in Primini & Kashyap (2014ApJ...796…24P). Second, an MCMC procedure is used to estimate marginalized posterior probability distributions for source fluxes. Finally, for sources observed in multiple observations, a Bayesian Blocks algorithm (Scargle, et al. 2013ApJ...764..167S) is used to group observations into blocks of constant source flux.In this poster we present details of the CSC2.0 photometry algorithms and illustrate their performance in actual CSC2.0 datasets.This work has been supported by NASA under contract NAS 8-03060 to the Smithsonian Astrophysical Observatory for operation of the Chandra X-ray Center.

Reinforce: An Ensemble Approach for Inferring PPI Network from AP-MS Data.

PubMed

Tian, Bo; Duan, Qiong; Zhao, Can; Teng, Ben; He, Zengyou

2017-05-17

Affinity Purification-Mass Spectrometry (AP-MS) is one of the most important technologies for constructing protein-protein interaction (PPI) networks. In this paper, we propose an ensemble method, Reinforce, for inferring PPI network from AP-MS data set. The new algorithm named Reinforce is based on rank aggregation and false discovery rate control. Under the null hypothesis that the interaction scores from different scoring methods are randomly generated, Reinforce follows three steps to integrate multiple ranking results from different algorithms or different data sets. The experimental results show that Reinforce can get more stable and accurate inference results than existing algorithms. The source codes of Reinforce and data sets used in the experiments are available at: https://sourceforge.net/projects/reinforce/.

BOOSTER CHLORINATION FOR MANAGING DISINFECTANT RESIDUALS

EPA Science Inventory

Booster chlorination is an approach to residual maintenance in which chlorine is applied at strategic locations within the distribution system. Situations in which booster chlorination may be most effective for maintaining a residual are explained informally in the context of a ...

Identifying information that promotes belt-positioning booster use. Volume 2, Appendices

DOT National Transportation Integrated Search

2008-07-01

Many parents with low educational attainment prematurely graduate their children to seat belt restraint rather than use belt-positioning booster seats. This study aimed to identify interventions that promoted booster seat use among this population. F...

9. VIEW OF BOOSTER STATION 3 INTERIOR, FACING NORTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. VIEW OF BOOSTER STATION 3 INTERIOR, FACING NORTHEAST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

6. VIEW OF BOOSTER STATION 2 INTERIOR, FACING WEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. VIEW OF BOOSTER STATION 2 INTERIOR, FACING WEST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

12. VIEW OF BOOSTER STATION 4 INTERIOR, FACING SOUTHWEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. VIEW OF BOOSTER STATION 4 INTERIOR, FACING SOUTHWEST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

3. VIEW OF BOOSTER STATION 1 INTERIOR, FACING EAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. VIEW OF BOOSTER STATION 1 INTERIOR, FACING EAST - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

Credit BG. Interior of Deluge Water Booster Station displaying highcapacity ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. Interior of Deluge Water Booster Station displaying high-capacity electrically driven water pumps for fire fighting service - Edwards Air Force Base, North Base, Deluge Water Booster Station, Northeast of A Street, Boron, Kern County, CA

Space shuttle system program definition. Volume 4: Cost and schedule report

NASA Technical Reports Server (NTRS)

1972-01-01

The supporting cost and schedule data for the second half of the Space Shuttle System Phase B Extension Study is summarized. The major objective for this period was to address the cost/schedule differences affecting final selection of the HO orbiter space shuttle system. The contending options under study included the following booster launch configurations: (1) series burn ballistic recoverable booster (BRB), (2) parallel burn ballistic recoverable booster (BRB), (3) series burn solid rocket motors (SRM's), and (4) parallel burn solid rocket motors (SRM's). The implications of varying payload bay sizes for the orbiter, engine type for the ballistics recoverable booster, and SRM motors for the solid booster were examined.

Acquired pellicle as a modulator for dental erosion.

PubMed

Vukosavljevic, Dusa; Custodio, William; Buzalaf, Marilia A R; Hara, Anderson T; Siqueira, Walter L

2014-06-01

Dental erosion is a multifactorial condition that can result in the loss of tooth structure and function, potentially increasing tooth sensitivity. The exposure of enamel to acids from non-bacterial sources is responsible for the progression of erosion. These erosive challenges are counteracted by the anti-erosive properties of the acquired pellicle (AP), an integument formed in vivo as a result of selective adsorption of salivary proteins on the tooth surface, containing also lipids and glycoproteins. This review provides an in-depth discussion regarding how the physical structure of the AP, along with its composition, contributes to AP anti-erosive properties. The physical properties that contribute to AP protective nature include pellicle thickness, maturation time, and site of development. The pellicle contains salivary proteins embedded within its structure that demonstrate anti-erosive properties; however, rather than individual proteins, protein-protein interactions play a fundamental role in the protective nature of the AP. In addition, dietary and synthetic proteins can modify the pellicle, enhancing its protective efficiency against dental erosion. The salivary composition of the AP and its corresponding protein-profile may be employed as a diagnostic tool, since it likely contains salivary biomarkers for oral diseases that initiate at the enamel surface, including dental erosion. Finally, by modifying the composition and structure of the AP, this protein integument has the potential to be used as a target-specific treatment option for oral diseases related to tooth demineralization. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Closeup view of the Solid Rocket Booster (SRB) Forward Skirt, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Close-up view of the Solid Rocket Booster (SRB) Forward Skirt, Frustum and Nose Cap mated assembly undergoing final preparations in the Solid Rocket Booster Assembly and Refurbishment Facility at Kennedy Space Center. In this view the access panel on the Forward Skirt is removed and you can see a small portion of the interior of the Forward Skirt. - Space Transportation System, Solid Rocket Boosters, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

STS-26 solid rocket booster post flight structural assessment

NASA Technical Reports Server (NTRS)

Herda, David A.; Finnegan, Charles J.

1988-01-01

A post flight assessment of the Space Shuttle's Solid Rocket Boosters was conducted at the John F. Kennedy Space Center in Florida after the launch of STS-26. The two boosters were inspected for structural damage and the results of this inspection are presented. Overall, the boosters were in good condition. However, there was some minor damage attributed to splash down. Some of this damage is a recurring problem. Explanations of these problems are provided.

NASA SLS Booster Nozzle Plug Pieces Fly During Test

NASA Image and Video Library

2016-06-28

On June 28, a test version of the booster that will help power NASA's new rocket, the Space Launch System, fired up at nearly 6,000 degrees Fahrenheit for a successful, two-minute qualification test at Orbital ATK's test facilities in Promontory, Utah. This video shows the booster's nozzle plug intentionally breaking apart. The smoky ring coming off the booster is condensed water vapor created by a pressure difference between the motor gas and normal air. The nozzle plug is an environmental barrier to prevent heat, dust and moisture from getting inside the booster before it ignites. The plug isn't always part of a static test but was included on this one due to changes made to the hardware. The foam on the plug is denser than previous NASA launch vehicles, as the engines are now in the same plane as the boosters. A numbered grid was placed on the exterior of the plug before the test so the pieces retrieved could support plug breakup assessment and reconstruction. Along with video, collecting the pieces helps determine the size and speed of them when they break apart. Nozzle plug pieces were found as far as 1,500 to 2,000 feet away from the booster. This is the last full-scale qualification test for the booster before the first, uncrewed flight of SLS with the Orion spacecraft in 2018.

Evaluation of a Booster Intervention Three Years after Acute Treatment for Early-Onset Disruptive Behavior Disorders

PubMed Central

Lindhiem, Oliver; Hart, Jonathan; Bukstein, Oscar G.

2013-01-01

This study examines the impact of a brief booster treatment administered three years after the delivery of an acute treatment in a group (N = 118) of clinically referred boys and girls (ages 6 to 11) originally diagnosed with Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD). At the conclusion of the acute treatment and three-year follow-up period (i.e., study month 42), the sample was re-randomized into Booster treatment or Enhanced Usual Care and then assessed at four later timepoints (i.e., post-booster, and 6-, 12- and 24-month booster follow-up). Booster treatment was directed towards addressing individualized problems and some unique developmental issues of adolescence based on the same original protocol content and treatment setting, whereas the no-booster condition involved providing clinical recommendations based on the assessment and an outside referral for services. HLM analyses identified no significant group differences and few time effects across child, parent, and teacher reports on a broad range of child functioning and impairment outcomes. Analyses examining the role of putative moderators or mediators (e.g., severity of externalizing behavior, dose of treatment) were likewise non-significant. We discuss the nature and implications of these novel findings regarding the role and timing of booster treatment to address the continuity of DBD over time. PMID:23494526

Antibody persistence of two pentavalent DTwP-HB-Hib vaccines to the age of 15-18 months, and response to the booster dose of quadrivalent DTwP-Hib vaccine.

PubMed

Sharma, Hitt; Yadav, Sangeeta; Lalwani, Sanjay; Kapre, Subhash; Jadhav, Suresh; Parekh, Sameer; Palkar, Sonali; Ravetkar, Satish; Bahl, Sunil; Kumar, Rakesh; Shewale, Sunil

2013-01-07

Antibody persistence in children following three doses of primary vaccination with diphtheria, tetanus, whole-cell-pertussis (DTwP), hepatitis B, and Haemophilus influenzae type b (Hib) vaccines (SIIL Pentavac vaccine vs. Easyfive(®) of Panacea Biotec), and response to the booster dose of DTwP-Hib (Quadrovax(®)) vaccine. Children who completed their primary immunization were assessed for antibodies at 15-18 months of age, and then given a booster dose of DTwP-Hib vaccine. Reactogenicity and safety of the booster dose was evaluated. Both pentavalent vaccines demonstrated a good immune response at 15-18 months. Following the booster dose, all vaccinated subjects achieved protective titers against diphtheria, tetanus and Hib, whereas the response to pertussis antigen was ~78%. Fever and irritability was noted in 24%, local pain in 51%, and swelling in 36% of the children following booster dose. Primary immunization with either pentavalent vaccine induced an excellent immunity lasting till the second year of life. A booster dose with DTwP-Hib (Quadrovax(®)) vaccine effectuated a good anamnestic response to all vaccine components, being specially strong for Hib in children previously vaccinated with SIIL liquid pentavalent vaccine (Pentavac(®)). Also, the safety profile of SIIL quadrivalent vaccine (Quadrovax(®)) administered as booster dose was acceptable. Copyright © 2012 Elsevier Ltd. All rights reserved.

Identifying information that promotes belt-positioning booster use. Volume 1, Summary and findings

DOT National Transportation Integrated Search

2008-07-01

Many parents with low educational attainment prematurely graduate their children to seat belt restraint rather than use belt-positioning booster seats. This study aimed to identify interventions that promoted booster seat use among this population. F...

13. VIEW OF BOOSTER STATION 4 CHLORINATOR INTERIOR, FACING NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. VIEW OF BOOSTER STATION 4 CHLORINATOR INTERIOR, FACING NORTH - Nevada Test Site, Frenchman Flat Test Facility, Well Five Booster Stations, Intersection of 5-03 Road & Short Pole Line Road, Area 5, Frenchman Flat, Mercury, Nye County, NV

INFLUENCE OF REMOTE SENSING IMAGERY SOURCE ON QUANTIFICATION OF RIPARIAN LAND COVER/LAND USE

EPA Science Inventory

This paper compares approaches to quantifying land cover/land use (LCLU) in riparian corridors of 23 watersheds in Oregon's Willamette Valley using aerial photography (AP) and Thematic Mapper (TM) imagery. For each imagery source, we quantified LCLU adjacent to stream networks ac...

Fermi LAT detection of increase gamma-ray emission from OJ 248

NASA Astrophysics Data System (ADS)

Orienti, M.; D'Ammando, F.

2012-09-01

The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar OJ 248 (also known as 2FGL J0830.5+2407, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 127.7170254 deg, Dec: 24.1832836 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=0.94 (Hewitt & Burbidge 1993, ApJS, 87, 451).

Fermi LAT detection of increased gamma-ray activity from the blazar TXS 1318+225

NASA Astrophysics Data System (ADS)

Torresi, E.; D'Ammando, F.; Tanaka, Y.

2012-11-01

The Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope, has observed an increase in the gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar TXS 1318+225 (z=0.943, Sowards-Emmerd et al. 2003, ApJ, 590, 109; RA=200.2966771 deg, Dec=22.2700300 deg, J2000), also known as 2FGL J1321.1+2215 (Nolan et al. 2012, ApJS, 199, 31).

Fermi LAT detection of a continuing increase of gamma-ray activity of CTA 102

NASA Astrophysics Data System (ADS)

Orienti, M.; D'Ammando, F.

2012-09-01

The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar CTA 102 (also known as 2FGL J2232.4+1143, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 338.1517038 deg, Dec: 11.7308067 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=1.037 (Schmidt 1965, ApJ, 141, 1295).

Predictors of Booster Response to Hepatitis B Vaccine at 15 years of age: A Cross-Sectional School-Based Study.

PubMed

Chen, Yu-Sheng; Chu, Chia-Hsiang; Wang, Jen-Hung; Lin, Jun-Song; Chang, Yung-Chieh

2016-08-01

The current consensus does not support the use of booster dose because of its anamnestic response in almost all children 15 years after universal infant hepatitis B virus (HBV) vaccination. However, in our clinical setting, numerous concerned parents request a booster administration for their children. We aimed to provide the possible predictors of booster response in adolescents before this booster administration. This study comprised a series of cross-sectional serological surveys of HBV markers in 15-year-old individuals between 2008 and 2012. Data on serum hepatitis B surface antigen, hepatitis B surface antibody (anti-HBs), and liver-function biomarkers in a total of 887 senior high-school students were collected. There were two parts to this study: HBV seroepidemiology and booster-response analysis to identify the possible response predictors and decay factors after the HBV booster administration. The overall anti-HBs and hepatitis B surface antigen seropositivity rates were 34.7% and 0.7%, respectively, and the median anti-HBs titer was 3.3 mIU/mL. Six weeks after one dose of recombinant HBV vaccine, the overall booster-response rate in the double-seronegative recipients was 94% (471/501). Among the participants whose initial anti-HBs titers were undetectable or low, 72.4% (247/341) and 95.6% (153/160), respectively, reactivated their anti-HBs titers ≥ 100 mIU/mL about 6 weeks after the booster administration. The likelihood of postbooster anti-HBs titer reaching an adequate protective level increased with the prebooster titer. The female participants had stronger anamnestic responses compared to the male participants. We found that the female participants and prebooster anti-HBs titers above the detection limit of the immunoassay were good predictors of HBV booster response. Copyright © 2015. Published by Elsevier B.V.

HLA-DPB1 and anti-HBs titer kinetics in hepatitis B booster recipients who completed primary hepatitis B vaccination during infancy.

PubMed

Wu, T-W; Chu, C-C; Liao, H-W Chang; Lin, S-K; Ho, T-Y; Lin, M; Lin, H H; Wang, L-Y

2014-01-01

Previously we reported significant associations of the human leukocyte antigen (HLA)-DPB1 05:01 with memory against hepatitis B (HB) vaccination. However, the effects of HLA-DPB1 on antibodies to hepatitis B surface antigen (anti-HBs) kinetics were not explored. We followed up a cohort of 1974 HB booster recipients and quantified their 1-month and 1-year post-booster anti-HBs titers. A total of 681 subjects were randomly selected and typed for HLA-DPB1. We found that male subjects, undetectable pre-booster titers, and 05:01 homozygotes led to significantly lower post-booster anti-HBs titers. The geometric means (95% confidence interval (CI)) of 1-month post-booster anti-HBs titers were 4.68 (2.69-8.12), 23.01 (14.96-35.40) and 50.06 (27.20-92.13) mIU ml(-1) for subjects carrying two, one and no HLA-DPB1 05:01 allele. The corresponding figures for 1-year post-booster anti-HBs titers were 1.26 (0.73-2.18), 4.72 (3.08-7.25) and 7.32 (3.75-13.56) mIU ml(-1). There were significant associations of post-booster anti-HBs titers with the number of HLA-DPB1 risk and protective alleles. Among booster responders, anti-HBs decay rates were significantly reduced in subjects who had detectable pre-booster anti-HBs titers and the HLA-DPB1 05:01 allele. Our results indicated that HLA-DPB1 influences the kinetics of anti-HBs. The long-term memory against hepatitis B surface antigen (HBsAg) and the residual serum titers of anti-HBs after HB vaccination may be influenced by different mechanisms as evidenced by their inverse trend of associations with the 05:01 allele.

Persistence of antibodies six years after booster vaccination with inactivated vaccine against Japanese encephalitis.

PubMed

Paulke-Korinek, Maria; Kollaritsch, Herwig; Kundi, Michael; Zwazl, Ines; Seidl-Friedrich, Claudia; Jelinek, Tomas

2015-07-09

Japanese Encephalitis (JE) virus occurs in wide regions of Asia with over 3 billion people living in areas at risk for JE. An estimated 68,000 clinical cases of JE occur every year, and vaccination is the most effective prophylactic measure. One internationally licensed vaccine containing the inactivated JE virus strain SA14-14-2 is Ixiaro (Valneva, Austria). According to recommendations, basic immunization consists of vaccinations on day 0, day 28, and a booster dose 12-24 months later. Protection in terms of neutralizing antibody titers has been assessed up to 12 months after the third dose of the vaccine. The current investigation was designed to evaluate antibody decline over time and to predict long-term duration of seroprotection after a booster dose. In a preceding trial, volunteers received basic immunization (day 0, day 28) and one booster dose against JE 15 months later. A follow up blood draw 6 years following their booster dose was carried out in 67 subjects. For antibody testing, a 50% plaque reduction neutralization test (PRNT50-test) was used. PRNT50 values of 10 and above are surrogate levels of protection according to WHO standards. Seventy-six months following the booster dose, 96% of the tested subjects had PRNT50 titers of 10 or higher. Geometric mean titer (GMT) was 148 (95% CI confidence interval: 107-207). Antibody titers were lower in volunteers 50 years of age and older. Vaccination history against other flaviviruses (yellow fever or tick borne encephalitis) did not significantly influence PRNT50 titers. A two-step log-linear decline model predicted protection against JE of approximately 14 years after the booster dose. Six years after a booster dose against JE, long-term protection could be demonstrated. According to our results, further booster doses should be scheduled 10 years following the first booster dose. Copyright © 2015 Elsevier Ltd. All rights reserved.

Antibody persistence and the effect of a booster dose given 5, 10 or 15 years after vaccinating preadolescents with a recombinant hepatitis B vaccine.

PubMed

Gilca, Vladimir; De Serres, Gaston; Boulianne, Nicole; Murphy, Donald; De Wals, Philippe; Ouakki, Manale; Trudeau, Gisele; Massé, Richard; Dionne, Marc

2013-01-07

The persistence of antibody obtained post-vaccination of preadolescents with three doses of Engerix-B and the effect of a booster administered 5, 10 or 15 years later were monitored in 663 vaccinees. Five, 10 and 15 years post-vaccination >94% of subjects had detectable antibodies and 88.2%, 86.4% and 76.7% had a titre ≥10 IU/L; GMTs were 269 IU/L, 169 IU/L and 51 IU/L, respectively; 99.1-100% vaccinees reached a titre ≥10 IU/l post-booster. GMTs were 118012 IU/L, 32477 IU/L, and 13946 IU/L when the booster was administered 5, 10 or 15 years post-vaccination, respectively. We conclude that vaccination induces immunity in the great majority of vaccinees for at least 15 years. The response to a booster dose suggests persistence of immune memory in almost all vaccinees. Although a booster dose increases substantially anti-HBs titres, the clinical relevance of such an increase remains unknown. These results do not support the need of a booster for at least 15 years when vaccinating preadolescents with Engerix-B. Copyright © 2012 Elsevier Ltd. All rights reserved.

Finite Element Analysis of High Heat Load Deformation and Mechanical Bending Correction of a Beamline Mirror for the APS Upgrade

NASA Astrophysics Data System (ADS)

Goldring, Nicholas

The impending Advanced Photon Source Upgrade (APS-U) will introduce a hard x-ray source that is set to surpass the current APS in brightness and coherence by two to three orders of magnitude. To achieve this, the storage ring light source will be equipped with a multi-bend achromat (MBA) lattice. In order to fully exploit and preserve the integrity of new beams actualized by upgraded storage ring components, improved beamline optics must also be introduced. The design process of new optics for the APS-U and other fourth generation synchrotrons involves the challenge of accommodating unprecedented heat loads. This dissertation presents an ex-situ analysis of heat load deformation and the subsequent mechanical bending correction of a 400 mm long, grazing-incidence, H2O side-cooled, reflecting mirror subjected to x-ray beams produced by the APS-U undulator source. Bending correction is measured as the smallest rms slope error, sigmarms, that can be resolved over a given length of the heat deformed geometry due to mechanical bending. Values of sigmarms in the <0.1 microrad regime represent a given mirror length over which incident x-ray beams from modern sources can be reflected without significant loss of quality. This study assumes a perfectly flat mirror surface and does not account for finish errors or other contributions to sigmarms beyond the scope of thermal deformation and elastic bending. The methodology of this research includes finite element analysis (FEA) employed conjointly with an analytical solution for mechanical bending deflection by means of an end couple. Additionally, the study will focus on two beam power density profiles predicted by the APS-U which were created using the software SRCalc. The profiles account for a 6 GeV electron beam with second moment widths of 0.058 and 0.011 mm in the x- and y- directions respectively; the electron beam is passed through a 4.8 m long, 28 mm period APS-U undulator which produces the x-ray beam incident at a 3 mrad grazing angle on the flat mirror surface for both cases. The first power density profile is the most extreme case created by the undulator at it's closest gap with a critical energy of 3 keV (k y=2.459); the second profile is generated for the case in which the undulator is tuned to emit at 8 keV (ky=1.026). The 3 keV case is of particular interest as it represents one of the most intense peak heat loads predicted to be incident on first optics at the APS-U. The FEA results revealed that the deflection due to the 3 keV heat load yields a 10.9 microrad rms slope error over the full mirror length. The projected correction via the elastic bending of the substrate yields a 0.10 microrad sigma rms within the center longitudinal 300 mm. The FEA also predicts that the 8 keV heat load deflection can be corrected to a sigma rms of 0.11 microrad within the center 300 mm from 1.50 microrad over the entire length. Attempts to optimize the end couple to correct over the entire 400 mm mirror length were unable to resolve the heat load deflection rms slope error to within a <0.1 microrad value for either case. However, if a larger corrected surface is required, a longer mirror can be implemented so as to absorb the heat load of a larger beam than necessary which can then be cut by an aperture to the desired size and energy range.

Identifying strategies to improve the effectiveness of booster seat laws

DOT National Transportation Integrated Search

2008-05-01

The objective of this project was to identify strategies to improve the effectiveness of booster seat laws. The project explored the possible factors that relate to the use and nonuse of booster seats, and examined the attitudes of law enforcement of...

Booster seat law enforcement : examples from Delaware, New Jersey, Pennsylvania, and Washington.

DOT National Transportation Integrated Search

2010-02-01

The objective of this study was to evaluate the implementation of State booster seat laws : (enhanced child restraint laws) and examine the most effective strategies that law enforcement agencies can : use to enforce booster seat laws. The research i...

Space transportation booster engine configuration study. Volume 1: Executive Summary

NASA Technical Reports Server (NTRS)

1989-01-01

The objective of the Space Transportation Booster Engine (STBE) Configuration Study is to contribute to the Advanced Launch System (ALS) development effort by providing highly reliable, low cost booster engine concepts for both expendable and reusable rocket engines. The objectives of the Space Transportation Booster Engine (STBE) Configuration Study were to identify engine configurations which enhance vehicle performance and provide operational flexibility at low cost, and to explore innovative approaches to the follow-on full-scale development (FSD) phase for the STBE.

VizieR Online Data Catalog: New IR photometric study of Ap and Am stars (Chen+, 2017)

NASA Astrophysics Data System (ADS)

Chen, P. S.; Liu, J. Y.; Shan, H. G.

2018-05-01

In the General Catalog of Ap and Am stars (Renson & Manfroid 2009, Cat. III/260) 8265 stars are included in which, as Renson & Manfroid (2009, Cat. III/260) described, only 426 stars are of the "well known confirmed sample". We take these 426 stars as our working sample. The cross-identifications of 2MASS/WISE counterparts for all Ap, Am, and HgMn stars listed in this paper are made from Cutri et al. (2012, Cat. II/311) by using the radius of 2 arcsec. All 426 Ap, Am, and HgMn stars have 2MASS and/or WISE counterparts, which are listed in Table 3. The cross-identifications of IRAS counterparts are made according to the positional error ellipse of the source, because it has a 95% confidence level (IRAS Explanatory Supplement, Beichman et al. 1988, Cat. II/274). Finally, 202 stars are found to have the IRAS counterparts from IRAS PSC/FSC, which is listed in Table 4. (5 data files).

Is Ammonium Peroxydisulate Indispensable for Preparation of Aniline-Derived Iron-Nitrogen-Carbon Electrocatalysts?

PubMed

Xie, Nan-Hong; Yan, Xiang-Hui; Xu, Bo-Qing

2016-09-08

Iron and nitrogen co-doped carbon (Fe-N-C) materials are among the most active non-precious metal catalysts that could replace Pt-based electrocatalysts for the oxygen reduction reaction (ORR) in fuel cells and metal-air batteries. The synthesis of the Fe-N-C catalysts often involves the use of aniline as the precursor for both N and C and ammonium peroxydisulfate (APS) as an indispensable oxidative initiator for aniline polymerization. Herein, a detailed structure and catalytic ORR performance comparison of aniline-derived Fe-N-C catalysts synthesized with and without the use of APS is reported. The APS-free preparation, which uses Fe(III) ions as the Fe source as well as the aniline polymerization initiator, results in a simple Fe-N-C catalyst with a high activity for the ORR. We show that APS is not necessary for the preparation and even detrimental to the performance of the catalyst. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Child posture and shoulder belt fit during extended night-time traveling: an in-transit observational study.

PubMed

Forman, Jason L; Segui-Gomez, Maria; Ash, Joseph H; Lopez-Valdes, Francisco J

2011-01-01

Understanding pediatric occupant postures can help researchers indentify injury risk factors, and provide information for prospective injury prediction. This study sought to observe lateral head positions and shoulder belt fit among older child automobile occupants during a scenario likely to result in sleeping - extended travel during the night. An observational, volunteer, in-transit study was performed with 30 pediatric rear-seat passengers, ages 7 to 14. Each was restrained by a three-point seatbelt and was driven for seventy-five minutes at night. Ten subjects used a high-back booster seat, ten used a low-back booster seat, and ten used none (based on the subject height and weight). The subjects were recorded with a low-light video camera, and one frame was analyzed per each minute of video. The high-back booster group exhibited a statistically significant (p<0.05) decrease in the mean frequency of poor shoulder belt fit compared to the no-booster and low-back booster groups. The high-back booster group also exhibited statistically significant decreases in the 90(th) percentile of the absolute value of the relative lateral motion of the head. The low-back booster group did not result in statistically significant decreases in poor shoulder belt fit or lateral head motion compared to the no-booster group. These results are consistent with the presence of large lateral supports of the high-back booster which provided support to the head while sleeping, reducing voluntary lateral occupant motion and improving shoulder belt fit. Future work includes examining lap belt fit in-transit, and examining the effects of these observations on predicted injury risk.

Child Posture and Shoulder Belt Fit During Extended Night-Time Traveling: An In-Transit Observational Study.

PubMed Central

Forman, Jason L.; Segui-Gomez, Maria; Ash, Joseph H.; Lopez-Valdes, Francisco J.

2011-01-01

Understanding pediatric occupant postures can help researchers indentify injury risk factors, and provide information for prospective injury prediction. This study sought to observe lateral head positions and shoulder belt fit among older child automobile occupants during a scenario likely to result in sleeping - extended travel during the night. An observational, volunteer, in-transit study was performed with 30 pediatric rear-seat passengers, ages 7 to 14. Each was restrained by a three-point seatbelt and was driven for seventy-five minutes at night. Ten subjects used a high-back booster seat, ten used a low-back booster seat, and ten used none (based on the subject height and weight). The subjects were recorded with a low-light video camera, and one frame was analyzed per each minute of video. The high-back booster group exhibited a statistically significant (p<0.05) decrease in the mean frequency of poor shoulder belt fit compared to the no-booster and low-back booster groups. The high-back booster group also exhibited statistically significant decreases in the 90th percentile of the absolute value of the relative lateral motion of the head. The low-back booster group did not result in statistically significant decreases in poor shoulder belt fit or lateral head motion compared to the no-booster group. These results are consistent with the presence of large lateral supports of the high-back booster which provided support to the head while sleeping, reducing voluntary lateral occupant motion and improving shoulder belt fit. Future work includes examining lap belt fit in-transit, and examining the effects of these observations on predicted injury risk. PMID:22105378

Impact of Booster Breaks and Computer Prompts on Physical Activity and Sedentary Behavior Among Desk-Based Workers: A Cluster-Randomized Controlled Trial.

PubMed

Taylor, Wendell C; Paxton, Raheem J; Shegog, Ross; Coan, Sharon P; Dubin, Allison; Page, Timothy F; Rempel, David M

2016-11-17

The 15-minute work break provides an opportunity to promote health, yet few studies have examined this part of the workday. We studied physical activity and sedentary behavior among office workers and compared the results of the Booster Break program with those of a second intervention and a control group to determine whether the Booster Break program improved physical and behavioral health outcomes. We conducted a 3-arm, cluster-randomized controlled trial at 4 worksites in Texas from 2010 through 2013 to compare a group-based, structured Booster Break program to an individual-based computer-prompt intervention and a usual-break control group; we analyzed physiologic, behavioral, and employee measures such as work social support, quality of life, and perceived stress. We also identified consistent and inconsistent attendees of the Booster Break sessions. We obtained data from 175 participants (mean age, 43 y; 67% racial/ethnic minority). Compared with the other groups, the consistent Booster Break attendees had greater weekly pedometer counts (P < .001), significant decreases in sedentary behavior and self-reported leisure-time physical activity (P < .001), and a significant increase in triglyceride concentrations (P = .02) (levels remained within the normal range). Usual-break participants significantly increased their body mass index, whereas Booster Break participants maintained body mass index status during the 6 months. Overall, Booster Break participants were 6.8 and 4.3 times more likely to have decreases in BMI and weekend sedentary time, respectively, than usual-break participants. Findings varied among the 3 study groups; however, results indicate the potential for consistent attendees of the Booster Break intervention to achieve significant, positive changes related to physical activity, sedentary behavior, and body mass index.

Cost Effectiveness of a Shingles Vaccine Booster for Currently Vaccinated Adults in the U.S.

PubMed

Le, Phuc; Rothberg, Michael B

2017-12-01

The Advisory Committee on Immunization Practices recommends a single dose of the live attenuated herpes zoster vaccine in people aged ≥60 years. Because vaccine-induced protection decreases to zero after 10 years, many vaccinated people will soon be subject to an increased risk of the disease. The study objective was to determine the cost effectiveness of a herpes zoster vaccine booster and its optimal timing among immunocompetent adults first vaccinated at aged ≥60 years. A Markov model was built to follow vaccinated individuals for a lifetime. From the societal perspective, costs and quality-adjusted life years were compared between no booster versus booster options. A booster was given any time between 1 and 20 years after the first dose, and for those who had the first dose at different ages: 60, 70, and 80 years. Because people entered the model already vaccinated, costs and side effects of the first dose were not included. The booster was assumed to have the same efficacy and waning rate as the initial vaccination. Model inputs were based on published literature. A cost effectiveness threshold of $100,000/quality-adjusted life year was used. The analysis was conducted in 2016. Cost effectiveness of a booster varied by age and time since vaccination. The booster cost <$100,000/quality-adjusted life year if given >5 years after the initial dose, but was most cost effective at around 10 years. The finding was robust to wide variations in model inputs. Under current assumptions, a booster dose of herpes zoster vaccine would be cost effective for all vaccinated people 10 years after initial vaccination. Copyright © 2017 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Impact of Booster Breaks and Computer Prompts on Physical Activity and Sedentary Behavior Among Desk-Based Workers: A Cluster-Randomized Controlled Trial

PubMed Central

Paxton, Raheem J.; Shegog, Ross; Coan, Sharon P.; Dubin, Allison; Page, Timothy F.; Rempel, David M.

2016-01-01

Introduction The 15-minute work break provides an opportunity to promote health, yet few studies have examined this part of the workday. We studied physical activity and sedentary behavior among office workers and compared the results of the Booster Break program with those of a second intervention and a control group to determine whether the Booster Break program improved physical and behavioral health outcomes. Methods We conducted a 3-arm, cluster-randomized controlled trial at 4 worksites in Texas from 2010 through 2013 to compare a group-based, structured Booster Break program to an individual-based computer-prompt intervention and a usual-break control group; we analyzed physiologic, behavioral, and employee measures such as work social support, quality of life, and perceived stress. We also identified consistent and inconsistent attendees of the Booster Break sessions. Results We obtained data from 175 participants (mean age, 43 y; 67% racial/ethnic minority). Compared with the other groups, the consistent Booster Break attendees had greater weekly pedometer counts (P < .001), significant decreases in sedentary behavior and self-reported leisure-time physical activity (P < .001), and a significant increase in triglyceride concentrations (P = .02) (levels remained within the normal range). Usual-break participants significantly increased their body mass index, whereas Booster Break participants maintained body mass index status during the 6 months. Overall, Booster Break participants were 6.8 and 4.3 times more likely to have decreases in BMI and weekend sedentary time, respectively, than usual-break participants. Conclusion Findings varied among the 3 study groups; however, results indicate the potential for consistent attendees of the Booster Break intervention to achieve significant, positive changes related to physical activity, sedentary behavior, and body mass index. PMID:27854422

Response to booster doses of hepatitis B vaccine among young adults who had received neonatal vaccination.

PubMed

Chan, Paul K S; Ngai, Karry L K; Lao, Terence T; Wong, Martin C S; Cheung, Theresa; Yeung, Apple C M; Chan, Martin C W; Luk, Scotty W C

2014-01-01

Newborns who have received hepatitis B immunization in 1980s are now young adults joining healthcare disciplines. The need for booster, pre- and post-booster checks becomes a practical question. The aim of this study is to refine the HBV vaccination policy for newly admitted students in the future. A prospective study on medical and nursing school entrants to evaluate hepatitis B serostatus and the response to booster doses among young adults. Among 212 students, 17-23-year-old, born after adoption of neonatal immunization, 2 (0.9%) were HBsAg positive, 40 (18.9%) were anti-HBs positive. At 1 month after a single-dose booster for anti-HBs-negative students, 14.5% had anti-HBs <10 mIU/mL, 29.0% and 56.5% were 10-100 and >100 mIU/mL, respectively. The anti-HBs levels were significantly higher for females than males (mean [SD]: 431 [418] vs. 246 [339] mIU/mL, P = 0.047). At 2-4 month after the third booster dose, 97.1% had anti-HBs >100 mIU/mL and 2.9% had 10-100 mIU/mL. Pre-booster check is still worthwhile to identify carriers among newly recruited healthcare workers born after adoption of neonatal immunization. A 3-dose booster, rather than a single dose, is required for the majority to achieve an anti-HBs level >100 mIU/mL, as memory immunity has declined in a substantial proportion of individuals. Cost-effectiveness of post-booster check for anti-HBs is low and should be further evaluated based on contextual specific utilization of results.

The association between booster seat use and risk of death among motor vehicle occupants aged 4-8: a matched cohort study.

PubMed

Rice, T M; Anderson, C L; Lee, A S

2009-12-01

To estimate the effectiveness of booster seats and of seatbelts in reducing the risk of child death during traffic collisions and to examine possible effect modification by various collision and vehicle characteristics. A matched cohort study was conducted using data from the Fatality Analysis Reporting System. Death risk ratios were estimated with conditional Poisson regression, bootstrapped coefficient standard errors, and multiply imputed missing values using chained equations. Estimated death risk ratios for booster seats used with seatbelts were 0.33 (95% CI 0.28 to 0.40) for children age 4-5 years and 0.45 (0.31 to 0.63) for children aged 6-8 years (Wald test of homogeneity p<0.005). The estimated risk ratios for seatbelt used alone were similar for the two age groups, 0.37 (0.32 to 0.43) and 0.39 (0.34 to 0.44) for ages 4-5 and 6-8, respectively (Wald p = 0.61). Estimated booster seat effectiveness was significantly greater for inbound seating positions (Wald p = 0.05) and during rollovers collisions (Wald p = 0.01). Significant variability in risk ratio estimates was not observed across levels of calendar year, vehicle model year, vehicle type, or land use. Seatbelts, used with or without booster seats, are highly effective in preventing death among motor vehicle occupants aged 4-8 years. Booster seats do not appear to improve the performance of seatbelts with respect to preventing death (risk ratio 0.92, 95% CI 0.79 to 1.08, comparing seatbelts with boosters to seatbelts alone), but because several studies have found that booster seats reduce non-fatal injury severity, clinicians and injury prevention specialists should continue to recommend the use of boosters to parents of young children.

VizieR Online Data Catalog: Star-forming potential in the Perseus complex (Mercimek+, 2017)

NASA Astrophysics Data System (ADS)

Mercimek, S.; Myers, P. C.; Lee, K. I.; Sadavoy, S. I.

2018-05-01

We used published catalogs of cores and YSOs at different wavelengths ranging from sub-millimeter (850 μm) to infrared (1.25 μm). We focus on seven clumps in Perseus, which Sadavoy et al. (2014ApJ...787L..18S) showed in their Figure 1. They defined these clumps and their boundaries using a fitted Herschel-derived column density map. The column density threshold of AV~7 mag is proposed as a star formation threshold by Andre et al. (2010A&A...518L.102A), Lada et al. (2010ApJ...724..687L), and Evans et al. (2014ApJ...782..114E) and is equal to N(H2)~5x1021/cm2 (see also, Kirk et al. 2006, J/ApJ/646/1009; Andre et al. 2010A&A...518L.102A). We considered a core or YSO to be associated with a clump if it is located within the AV=7 mag contour of that clump from Sadavoy et al. (2014ApJ...787L..18S). We define a "source" to be a starless core or a YSO. (7 data files).

The qualification of the shuttle booster separation motors

NASA Technical Reports Server (NTRS)

Chase, C. A.; Fisher, K. M.; Eoff, W.

1978-01-01

Four booster separation motors (BSM) located at each end of every solid rocket booster (SRB) provide the needed side force to separate the boosters from the external tank at booster burnout. Four BSMs at the top of the SRB are located in a box pattern in the nose cone frustum. The four BSMs at the aft end of the SRB are arranged side-by-side on the SRB aft skirt. Aspects of BSM design and performance are considered, taking into account a motor design/performance summary, the case design, the insulation, the grain design, the nozzle/aft closure design, the ignition system, the propellant, and the motor assembly. Details of motor testing are also discussed, giving attention to development testing, qualification testing, and flight testing.

Longitudinal emittance measurements in the Booster and AGS during the 2014 RHIC gold run

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeno, K.

2014-08-18

This note describes longitudinal emittance measurements that were made in the Booster and AGS during the 2014 RHIC Gold run. It also contains an overview of the longitudinal aspects of their setup during this run. Each bunch intended for RHIC is composed of beam from 4 Booster cycles, and there are two of them per AGS cycle. For each of the 8 Booster cycles required to produce the 2 bunches in the AGS, a beam pulse from EVIS is injected into the Booster and captured in four h=4 buckets. Then those bunches are accelerated to a porch where they aremore » merged into 2 bunches and then into 1 bunch.« less

Study on the Structures of Two Booster Pellets Having High Initiation Capacity

NASA Astrophysics Data System (ADS)

Shuang-Qi, Hu; Hong-Rong, Liu; Li-shuang, Hu; Xiong, Cao; Xiang-Chao, Mi; Hai-Xia, Zhao

2014-05-01

Insensitive munitions (IM) improve the survivability of both weapons and their associated platforms, which can lead to a reduction in casualties, mission losses, and whole life costs. All weapon systems contain an explosive train that needs to meet IM criteria but reliably initiate a main charge explosive. To ensure that these diametrically opposed requirements can be achieved, new highly effective booster charge structures were designed. The initiation capacity of the two booster pellets was studied using varied composition and axial-steel-dent methods. The results showed that the two new booster pellets can initiate standard main charge pellets with less explosive mass than the ordinary cylindrical booster pellet. The numerical simulation results were in good agreement with the experiment results.

KSC-2011-1886

NASA Image and Video Library

2011-02-28

CAPE CANAVERAL, Fla. -- The Solid Rocket Booster Retrieval Ship Freedom Star tows a booster to the dock at Hangar AF on Cape Canaveral Air Force Station in Florida. The booster was used during space shuttle Discovery's STS-133 launch from NASA Kennedy Space Center's Launch Pad 39A on Feb. 24. The shuttle’s two solid rocket booster casings and associated flight hardware are recovered in the Atlantic Ocean after every launch by Liberty Star and Freedom Star. The boosters impact the Atlantic about seven minutes after liftoff and the retrieval ships are stationed about 10 miles from the impact area at the time of splashdown. After the spent segments are processed, they will be transported to Utah, where they will be refurbished and stored, if needed. Photo credit: NASA/Jim Grossmann

KSC-2011-1859

NASA Image and Video Library

2011-02-24

CAPE CANAVERAL, Fla. -- The right spent booster from shuttle Discovery's final launch is seen bobbing in the Atlantic Ocean. Crew members from Liberty Star, one of NASA's solid rocket booster retrieval ships, will recover the parachute and tow the booster back to Port Canaveral in Florida. The shuttle’s two solid rocket booster casings and associated flight hardware are recovered in the Atlantic Ocean after every launch by Freedom Star and Liberty Star. The boosters impact the Atlantic about seven minutes after liftoff and the retrieval ships are stationed about 10 miles from the impact area at the time of splashdown. After the spent segments are processed, they will be transported to Utah, where they will be refurbished and stored, if needed. Photo credit: NASA/Frank Michaux

Closeup view of the Solid Rocket Booster (SRB) Frustum mounted ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Close-up view of the Solid Rocket Booster (SRB) Frustum mounted on ground support equipment in the Solid Rocket Booster Assembly and Refurbishment Facility at Kennedy Space Center as it is being prepared to be mated with the Nose Cap and Forward Skirt. The Frustum contains the three Main Parachutes, Altitude Switches and forward booster Separation Motors. The Separation Motors burn for one second to ensure the SRBs drift away from the External Tank and Orbiter at separation. The three main parachutes are deployed to reduce speed as the SRBs descend to a splashdown in the Atlantic Ocean where they are recovered refurbished and reused. - Space Transportation System, Solid Rocket Boosters, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Biological substantiation of antipsychotic-associated pneumonia: Systematic literature review and computational analyses

PubMed Central

2017-01-01

Introduction Antipsychotic (AP) safety has been widely investigated. However, mechanisms underlying AP-associated pneumonia are not well-defined. Aim The aim of this study was to investigate the known mechanisms of AP-associated pneumonia through a systematic literature review, confirm these mechanisms using an independent data source on drug targets and attempt to identify novel AP drug targets potentially linked to pneumonia. Methods A search was conducted in Medline and Web of Science to identify studies exploring the association between pneumonia and antipsychotic use, from which information on hypothesized mechanism of action was extracted. All studies had to be in English and had to concern AP use as an intervention in persons of any age and for any indication, provided that the outcome was pneumonia. Information on the study design, population, exposure, outcome, risk estimate and mechanism of action was tabulated. Public repositories of pharmacology and drug safety data were used to identify the receptor binding profile and AP safety events. Cytoscape was then used to map biological pathways that could link AP targets and off-targets to pneumonia. Results The literature search yielded 200 articles; 41 were included in the review. Thirty studies reported a hypothesized mechanism of action, most commonly activation/inhibition of cholinergic, histaminergic and dopaminergic receptors. In vitro pharmacology data confirmed receptor affinities identified in the literature review. Two targets, thromboxane A2 receptor (TBXA2R) and platelet activating factor receptor (PTAFR) were found to be novel AP target receptors potentially associated with pneumonia. Biological pathways constructed using Cytoscape identified plausible biological links potentially leading to pneumonia downstream of TBXA2R and PTAFR. Conclusion Innovative approaches for biological substantiation of drug-adverse event associations may strengthen evidence on drug safety profiles and help to tailor pharmacological therapies to patient risk factors. PMID:29077727

Bio-oil based biorefinery strategy for the production of succinic acid.

PubMed

Wang, Caixia; Thygesen, Anders; Liu, Yilan; Li, Qiang; Yang, Maohua; Dang, Dan; Wang, Ze; Wan, Yinhua; Lin, Weigang; Xing, Jianmin

2013-01-01

Succinic acid is one of the key platform chemicals which can be produced via biotechnology process instead of petrochemical process. Biomass derived bio-oil have been investigated intensively as an alternative of diesel and gasoline fuels. Bio-oil could be fractionized into organic phase and aqueous phase parts. The organic phase bio-oil can be easily upgraded to transport fuel. The aqueous phase bio-oil (AP-bio-oil) is of low value. There is no report for its usage or upgrading via biological methods. In this paper, the use of AP-bio-oil for the production of succinic acid was investigated. The transgenic E. coli strain could grow in modified M9 medium containing 20 v/v% AP-bio-oil with an increase in OD from 0.25 to 1.09. And 0.38 g/L succinic acid was produced. With the presence of 4 g/L glucose in the medium, succinic acid concentration increased from 1.4 to 2.4 g/L by addition of 20 v/v% AP-bio-oil. When enzymatic hydrolysate of corn stover was used as carbon source, 10.3 g/L succinic acid was produced. The obtained succinic acid concentration increased to 11.5 g/L when 12.5 v/v% AP-bio-oil was added. However, it decreased to 8 g/L when 50 v/v% AP-bio-oil was added. GC-MS analysis revealed that some low molecular carbon compounds in the AP-bio-oil were utilized by E. coli. The results indicate that AP-bio-oil can be used by E. coli for cell growth and succinic acid production.

Bio-oil based biorefinery strategy for the production of succinic acid

PubMed Central

2013-01-01

Background Succinic acid is one of the key platform chemicals which can be produced via biotechnology process instead of petrochemical process. Biomass derived bio-oil have been investigated intensively as an alternative of diesel and gasoline fuels. Bio-oil could be fractionized into organic phase and aqueous phase parts. The organic phase bio-oil can be easily upgraded to transport fuel. The aqueous phase bio-oil (AP-bio-oil) is of low value. There is no report for its usage or upgrading via biological methods. In this paper, the use of AP-bio-oil for the production of succinic acid was investigated. Results The transgenic E. coli strain could grow in modified M9 medium containing 20 v/v% AP-bio-oil with an increase in OD from 0.25 to 1.09. And 0.38 g/L succinic acid was produced. With the presence of 4 g/L glucose in the medium, succinic acid concentration increased from 1.4 to 2.4 g/L by addition of 20 v/v% AP-bio-oil. When enzymatic hydrolysate of corn stover was used as carbon source, 10.3 g/L succinic acid was produced. The obtained succinic acid concentration increased to 11.5 g/L when 12.5 v/v% AP-bio-oil was added. However, it decreased to 8 g/L when 50 v/v% AP-bio-oil was added. GC-MS analysis revealed that some low molecular carbon compounds in the AP-bio-oil were utilized by E. coli. Conclusions The results indicate that AP-bio-oil can be used by E. coli for cell growth and succinic acid production. PMID:23657107

Biological substantiation of antipsychotic-associated pneumonia: Systematic literature review and computational analyses.

PubMed

Sultana, Janet; Calabró, Marco; Garcia-Serna, Ricard; Ferrajolo, Carmen; Crisafulli, Concetta; Mestres, Jordi; Trifirò', Gianluca

2017-01-01

Antipsychotic (AP) safety has been widely investigated. However, mechanisms underlying AP-associated pneumonia are not well-defined. The aim of this study was to investigate the known mechanisms of AP-associated pneumonia through a systematic literature review, confirm these mechanisms using an independent data source on drug targets and attempt to identify novel AP drug targets potentially linked to pneumonia. A search was conducted in Medline and Web of Science to identify studies exploring the association between pneumonia and antipsychotic use, from which information on hypothesized mechanism of action was extracted. All studies had to be in English and had to concern AP use as an intervention in persons of any age and for any indication, provided that the outcome was pneumonia. Information on the study design, population, exposure, outcome, risk estimate and mechanism of action was tabulated. Public repositories of pharmacology and drug safety data were used to identify the receptor binding profile and AP safety events. Cytoscape was then used to map biological pathways that could link AP targets and off-targets to pneumonia. The literature search yielded 200 articles; 41 were included in the review. Thirty studies reported a hypothesized mechanism of action, most commonly activation/inhibition of cholinergic, histaminergic and dopaminergic receptors. In vitro pharmacology data confirmed receptor affinities identified in the literature review. Two targets, thromboxane A2 receptor (TBXA2R) and platelet activating factor receptor (PTAFR) were found to be novel AP target receptors potentially associated with pneumonia. Biological pathways constructed using Cytoscape identified plausible biological links potentially leading to pneumonia downstream of TBXA2R and PTAFR. Innovative approaches for biological substantiation of drug-adverse event associations may strengthen evidence on drug safety profiles and help to tailor pharmacological therapies to patient risk factors.

Safety for Your Child: 6 Years

MedlinePlus

... the street without a grown-up. And Remember Car Safety Your child must now use a booster seat in the car. Always check to be sure that he or ... in the booster seat before you start the car. Your child should use a booster seat until ...

General view of a fully assembled Solid Rocket Booster sitting ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view of a fully assembled Solid Rocket Booster sitting atop the Mobile Launch Platform in the Vehicle Assembly Building at Kennedy Space Center - Space Transportation System, Solid Rocket Boosters, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

47 CFR 74.1232 - Eligibility and licensing requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Translator Stations and FM Broadcast Booster Stations § 74.1232 Eligibility and licensing requirements. (a... incurred by installing, repairing, or making adjustments to equipment. (f) An FM broadcast booster station... the booster station will retransmit, to serve areas within the protected contour of the primary...

47 CFR 74.635 - Unattended operation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... stations, and TV microwave booster stations may be operated unattended under the following conditions: (1... persons; (3) TV relay stations, TV STL stations, TV translator relay stations, and TV microwave booster..., an STL station (and any TV microwave booster station) associated with a TV broadcast station operated...

47 CFR 74.635 - Unattended operation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... stations, and TV microwave booster stations may be operated unattended under the following conditions: (1... persons; (3) TV relay stations, TV STL stations, TV translator relay stations, and TV microwave booster..., an STL station (and any TV microwave booster station) associated with a TV broadcast station operated...

Shuttle Boosters stacked in the VAB

NASA Image and Video Library

2007-01-04

Workers continue stacking the solid rocket boosters in highbay 1 inside Kennedy Space Center's Vehicle Assembly Building. The solid rocket boosters are being prepared for NASA's next Space Shuttle launch, mission STS-117. The mission is scheduled to launch aboard Atlantis no earlier than March 16, 2007.

47 CFR 74.1232 - Eligibility and licensing requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Translator Stations and FM Broadcast Booster Stations § 74.1232 Eligibility and licensing requirements. (a... incurred by installing, repairing, or making adjustments to equipment. (f) An FM broadcast booster station... the booster station will retransmit, to serve areas within the protected contour of the primary...

47 CFR 74.635 - Unattended operation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... stations, and TV microwave booster stations may be operated unattended under the following conditions: (1... persons; (3) TV relay stations, TV STL stations, TV translator relay stations, and TV microwave booster..., an STL station (and any TV microwave booster station) associated with a TV broadcast station operated...

47 CFR 74.635 - Unattended operation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... stations, and TV microwave booster stations may be operated unattended under the following conditions: (1... persons; (3) TV relay stations, TV STL stations, TV translator relay stations, and TV microwave booster..., an STL station (and any TV microwave booster station) associated with a TV broadcast station operated...

47 CFR 74.1232 - Eligibility and licensing requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Translator Stations and FM Broadcast Booster Stations § 74.1232 Eligibility and licensing requirements. (a... incurred by installing, repairing, or making adjustments to equipment. (f) An FM broadcast booster station... the booster station will retransmit, to serve areas within the protected contour of the primary...

47 CFR 74.1250 - Transmitters and associated equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Translator Stations and FM Broadcast Booster Stations § 74.1250 Transmitters and associated equipment. (a) FM translator and booster transmitting apparatus, and exciters employed to provide a locally generated and modulated input signal to translator and booster equipment, used by stations authorized under the provisions...

47 CFR 74.1250 - Transmitters and associated equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Translator Stations and FM Broadcast Booster Stations § 74.1250 Transmitters and associated equipment. (a) FM translator and booster transmitting apparatus, and exciters employed to provide a locally generated and modulated input signal to translator and booster equipment, used by stations authorized under the provisions...

47 CFR 74.1250 - Transmitters and associated equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Translator Stations and FM Broadcast Booster Stations § 74.1250 Transmitters and associated equipment. (a) FM translator and booster transmitting apparatus, and exciters employed to provide a locally generated and modulated input signal to translator and booster equipment, used by stations authorized under the provisions...

47 CFR 74.1250 - Transmitters and associated equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Translator Stations and FM Broadcast Booster Stations § 74.1250 Transmitters and associated equipment. (a) FM translator and booster transmitting apparatus, and exciters employed to provide a locally generated and modulated input signal to translator and booster equipment, used by stations authorized under the provisions...

Design and prototype tests of a large-aperture 37-53 MHz ferrite-tuned booster synchrotron cavity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mark S. Champion et al.

The Booster synchrotron at Fermilab employs eighteen 37-53 MHz ferrite-tuned double-gap coaxial radiofrequency cavities for acceleration of protons from 400 MeV to 8 GeV. The cavities have an aperture of 2.25 inches and operate at 55 kV per cavity. Future high duty factor operation of the Booster will be problematic due to unavoidable beam loss at the cavities resulting in excessive activation. The power amplifiers, high maintenance items, are mounted directly to the cavities in the tunnel. A proposed replacement for the Booster, the Proton Driver, will utilize the Booster radiofrequency cavities and requires not only a larger aperture, butmore » also higher voltage. A research and development program is underway at Fermilab to modify the Booster cavities to provide a 5-inch aperture and a 20% voltage increase. A prototype has been constructed and high power tests have bee completed. The cavity design and test results is presented.« less

A randomized clinical trial on the effectiveness of a reintegration training program versus booster sessions after short-term inpatient psychotherapy.

PubMed

Thunnissen, Moniek; Duivenvoorden, Hugo; Busschbach, Jan; Hakkaart-van Roijen, Leona; van Tilburg, Willem; Verheul, Roel; Trijsburg, Wim

2008-10-01

Although several studies show symptomatic improvements in patients with personality disorders after short-term inpatient psychotherapy, reintegration remains difficult. In this study the effectiveness of a specifically designed reintegration training program is investigated. One hundred twenty-eight patients were randomized to either a reintegration training program aimed at improving general functioning and work resumption, or booster sessions. Outcome measures used were symptom level, work status, absence from and impediments at work. The results showed that compliance in the booster session group was significantly better than in the reintegration training program. The percentage of persons with a paid job increased during the booster sessions from 64 to 87%, but not during the reintegration training (76%). There were no differences in the other outcome measures. We concluded that reintegration training was not more (cost)-effective than booster sessions. Our hypothesis is that continuity of care (same therapists and program) explains the favorable results of the booster sessions.

ION BEAM POLARIZATION DYNAMICS IN THE 8 GEV BOOSTER OF THE JLEIC PROJECT AT JLAB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kondratenko, A. M.; Kondratenko, M. A.; Morozov, Vasiliy

2016-05-01

In the Jefferson Lab’s Electron-Ion Collider (JLEIC) project, an injector of polarized ions into the collider ring is a superconducting 8 GeV booster. Both figure-8 and racetrack booster versions were considered. Our analysis showed that the figure-8 ring configuration allows one to preserve the polarization of any ion species during beam acceleration using only small longitudinal field with an integral less than 0.5 Tm. In the racetrack booster, to pre-serve the polarization of ions with the exception of deu-terons, it suffices to use a solenoidal Siberian snake with a maximum field integral of 30 Tm. To preserve deuteron polarization, wemore » propose to use arc magnets for the race-track booster structure with a field ramp rate of the order of 1 T/s. We calculate deuteron and proton beam polari-zations in both the figure-8 and racetrack boosters includ-ing alignment errors of their magnetic elements using the Zgoubi code.« less

Advanced Space Transportation Program (ASTP)

NASA Image and Video Library

2000-04-03

This is a computer generated image of a Shuttle launch utilizing 2nd generation Reusable Launch Vehicle (RLV) flyback boosters, a futuristic concept that is currently undergoing study by NASA's Space Launch Initiative (SLI) Propulsion Office, managed by the Marshall Space Fight Center in Huntsville, Alabama, working in conjunction with the Agency's Glenn Research Center in Cleveland, Ohio. Currently, after providing thrust to the Space Shuttle, the solid rocket boosters are parachuted into the sea and are retrieved for reuse. The SLI is considering vehicle concepts that would fly first-stage boosters back to a designated landing site after separation from the orbital vehicle. These flyback boosters would be powered by several jet engines integrated into the booster capable of providing over 100,000 pounds of thrust. The study will determine the requirements for the engines, identify risk mitigation activities, and identify costs associated with risk mitigation and jet engine development and production, as well as determine candidate jet engine options to pursue for the flyback booster.

Combating pertussis resurgence: One booster vaccination schedule does not fit all.

PubMed

Riolo, Maria A; Rohani, Pejman

2015-02-03

Pertussis has reemerged as a major public health concern in many countries where it was once considered well controlled. Although the mechanisms responsible for continued pertussis circulation and resurgence remain elusive and contentious, many countries have nevertheless recommended booster vaccinations, the timing and number of which vary widely. Here, using a stochastic, age-stratified transmission model, we searched for cost-effective booster vaccination strategies using a genetic algorithm. We did so assuming four hypothesized mechanisms underpinning contemporary pertussis epidemiology: (I) insufficient coverage, (II) frequent primary vaccine failure, (III) waning of vaccine-derived protection, and (IV) vaccine "leakiness." For scenarios I-IV, successful booster strategies were identified and varied considerably by mechanism. Especially notable is the inability of booster schedules to alleviate resurgence when vaccines are leaky. Critically, our findings argue that the ultimate effectiveness of vaccine booster schedules will likely depend on correctly pinpointing the causes of resurgence, with misdiagnosis of the problem epidemiologically ineffective and economically costly.

Space Launch System Booster Separation Aerodynamic Database Development and Uncertainty Quantification

NASA Technical Reports Server (NTRS)

Chan, David T.; Pinier, Jeremy T.; Wilcox, Floyd J., Jr.; Dalle, Derek J.; Rogers, Stuart E.; Gomez, Reynaldo J.

2016-01-01

The development of the aerodynamic database for the Space Launch System (SLS) booster separation environment has presented many challenges because of the complex physics of the ow around three independent bodies due to proximity e ects and jet inter- actions from the booster separation motors and the core stage engines. This aerodynamic environment is dicult to simulate in a wind tunnel experiment and also dicult to simu- late with computational uid dynamics. The database is further complicated by the high dimensionality of the independent variable space, which includes the orientation of the core stage, the relative positions and orientations of the solid rocket boosters, and the thrust lev- els of the various engines. Moreover, the clearance between the core stage and the boosters during the separation event is sensitive to the aerodynamic uncertainties of the database. This paper will present the development process for Version 3 of the SLS booster separa- tion aerodynamic database and the statistics-based uncertainty quanti cation process for the database.

Fuze for explosive magnetohydrodynamic generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Webb, G.

1976-12-23

An apparatus is examined by which high explosive charges are propelled into and detonated at the center of an MHD-X generator. The high explosive charge units are engaged and propelled by a reciprocating ram device. Detonating in each instance is achieved by striking with a firing pin a detonator charge that is in register with a booster charge, the booster charge being in detonating communication with the high explosive charge. Various safety requirements are satisfied by a spring loaded slider operating in a channel transverse and adjacent to the booster charge. The slide retains the detonator charge out of registermore » with the booster charge until a safety pin that holds the slider in place is pulled by a lanyard attached between the reciprocating ram and the safety pin. Removal of the safety pin permits the detonator charge to slide into alignment with the booster charge. Firing pin actuation is initiated by the slider at the instant the detonator charge and the booster charge come into register.« less

Pain Assessment and Management After a Knowledge Translation Booster Intervention.

PubMed

Stevens, Bonnie J; Yamada, Janet; Promislow, Sara; Barwick, Melanie; Pinard, Marie

2016-10-01

Inadequate pain treatment leaves hospitalized children vulnerable to immediate and long-term sequelae. A multidimensional knowledge translation intervention (ie, the Evidence-based Practice for Improving Quality [EPIQ]) improved pain assessment, management, and intensity outcomes in 16 units at 8 Canadian pediatric hospitals. The sustained effectiveness of EPIQ over time is unknown, however. The goals of this study were to determine the following: (1) sustainability of the impact of EPIQ on pain assessment, management, and intensity outcomes 12, 24, and 36 months after EPIQ; (2) effectiveness of a pain practice change booster (Booster) intervention to sustain EPIQ outcomes over time; and (3) influence of context on sustainability. A prospective, repeated measures, cluster randomized controlled trial was undertaken in the 16 EPIQ units, 12 months after EPIQ completion, to determine the effectiveness of a practice change booster (Booster) to sustain EPIQ outcomes. Generalized estimating equation models examined outcomes controlling for child and unit contextual factors. Outcomes achieved during EPIQ were sustained in the use of any pain assessment measure (P = .01) and a validated pain assessment measure in the EPIQ units (P = .02) up to 36 months after EPIQ. Statistically significant improvements in pain management practices persisted in EPIQ units; results varied across time. There were no significant differences in outcomes after implementation of the Booster between the Booster and Nonbooster groups. Improved pain assessment and management practices were sustained after EPIQ; however, the Booster did not seem to provide additional impact. Copyright © 2016 by the American Academy of Pediatrics.

Liquid Rocket Booster (LRB) for the Space Transportation System (STS) systems study. Appendix F: Performance and trajectory for ALS/LRB launch vehicles

NASA Technical Reports Server (NTRS)

1989-01-01

By simply combining two baseline pump-fed LOX/RP-1 Liquid Rocket Boosters (LRBs) with the Denver core, a launch vehicle (Option 1 Advanced Launch System (ALS)) is obtained that can perform both the 28.5 deg (ALS) mission and the polar orbit ALS mission. The Option 2 LRB was obtained by finding the optimum LOX/LH2 engine for the STS/LRB reference mission (70.5 K lb payload). Then this engine and booster were used to estimate ALS payload for the 28.5 deg inclination ALS mission. Previous studies indicated that the optimum number of STS/LRB engines is four. When the engine/booster sizing was performed, each engine had 478 K lb sea level thrust and the booster carried 625,000 lb of useable propellant. Two of these LRBs combined with the Denver core provided a launch vehicle that meets the payload requirements for both the ALS and STS reference missions. The Option 3 LRB uses common engines for the cores and boosters. The booster engines do not have the nozzle extension. These engines were sized as common ALS engines. An ALS launch vehicle that has six core engines and five engines per booster provides 109,100 lb payload for the 28.5 deg mission. Each of these LOX/LH2 LRBs carries 714,100 lb of useable propellant. It is estimated that the STS/LRB reference mission payload would be 75,900 lb.

Role of neutralizing antibodies and T-cells in pathogenesis of herpes simplex virus infection in congenitally athymic mice.

PubMed

Kapoor, A K; Buckmaster, A; Nash, A A; Field, H J; Wildy, P

1982-11-01

Congenitally athymic nude mice were infected with 10(4) p.f.u. herpes simplex type 1 (strain SC16). Following the passive transfer of neutralizing monoclonal antibodies (AP7, AP8 and AP12) it was observed that AP7 alone reduced the virus infectivity in the nervous system; AP8 and AP12 failed to protect mice probably due to poor in vivo binding to the neutralization site on the virus. Latent ganglionic infection could be established in nude mice following adoptive transfer of optimum number (2 x 10(7) cells/mouse) of immune lymph node cells from day 7 herpes virus-infected hairy immunocompetent donor mice. Moreover, in some of the immune lymph node cell protected nudes, latency could be maintained even in complete absence of neutralizing antibodies. Results of ear-ablation experiments revealed that removal of primary source of infection after day 5 of infection reduced the amount of virus in the ganglia and spinal cord. Acute neurological infection was not detected following transfer of protective anti-gp-D neutralizing antibody (LP2) in combination with removal of infected pinna. These data suggest that continuous seeding of virus occurs in related ganglia via the axonal route from infected ear pinna. It appears that local T-cell-mediated immune mechanisms are involved in maintenance of latency.

Human acylphosphatase cannot replace phosphoglycerate kinase in Saccharomyces cerevisiae.

PubMed

Van Hoek, P; Modesti, A; Ramponi, G; Kötter, P; van Dijken, J P; Pron, J T

2001-10-01

Human acylphosphatase (h-AP, EC 3.6.1.7) has been reported to catalyse the hydrolysis of the 1-phosphate group of 1,3-diphosphoglycerate. In vivo operation of this reaction in the yeast Saccharomyces cerevisiae would bypass phosphoglycerate kinase and thus reduce the ATP yield from glycolysis. To investigate whether h-AP can indeed replace the S. cerevisiae phosphoglycerate kinase, a multi-copy plasmid carrying the h-AP gene under control of the yeast TDH3 promoter was introduced into a pgk1 delta mutant of S. cerevisiae. A strain carrying the expression vector without the h-AP cassette was used as a reference. For both strains, steady-state carbon- and energy-limited chemostat cultures were obtained at a dilution rate of 0.10 h(-1) on a medium containing a mixture of glucose and ethanol (15% and 85% on a carbon basis, respectively). Although the h-AP strain exhibited a high acylphosphatase activity in cell extracts, switching to glucose as sole carbon and energy source resulted in a complete arrest of glucose consumption and growth. The lack of a functional glycolytic pathway was further evident from the absence of ethanol formation in the presence of excess glucose in the culture. As h-AP cannot replace yeast phosphoglycerate kinase in vivo, the enzyme is not a useful tool to modify the ATP yield of glycolysis in S. cerevisiae.

Pre-College Sources of Influence for Traditionally Underrepresented Students Attending College: A Social Network Analysis Approach

ERIC Educational Resources Information Center

Kester, Rebekah G.

2017-01-01

This study examined a variety of sources of influence for traditionally underrepresented students at a primarily White institution of higher education. The sources of influence ranged from 2-way communications in high school to 2-way communications in the community, and from 1-way communication influences in the school such as AP courses, to 1-way…

47 CFR 74.750 - Transmission system facilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Translator, and TV Booster Stations § 74.750 Transmission system facilities. (a) A low power TV, TV translator, or TV booster station shall operate with a transmitter that is either certificated for licensing... rebroadcasting TV booster transmitting equipment using a modulation process must meet the following requirements...

47 CFR 74.750 - Transmission system facilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Translator, and TV Booster Stations § 74.750 Transmission system facilities. (a) A low power TV, TV translator, or TV booster station shall operate with a transmitter that is either certificated for licensing... rebroadcasting TV booster transmitting equipment using a modulation process must meet the following requirements...

Shuttle Boosters stacked in the VAB

NASA Image and Video Library

2007-01-04

Workers continue stacking the twin solid rocket boosters in highbay 1 inside Kennedy Space Center's Vehicle Assembly Building. The solid rocket boosters are being prepared for NASA's next Space Shuttle launch, mission STS-117. The mission is scheduled to launch aboard Atlantis no earlier than March 16, 2007.

47 CFR 74.1201 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FM Broadcast Booster Stations § 74.1201 Definitions. (a) FM translator. A station in the broadcasting... retransmitted by an FM broadcast translator station or an FM broadcast booster station. (e) AM or FM radio... indicates otherwise. (f) FM broadcast booster station. A station in the broadcasting service operated for...

47 CFR 74.1201 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... FM Broadcast Booster Stations § 74.1201 Definitions. (a) FM translator. A station in the broadcasting... retransmitted by an FM broadcast translator station or an FM broadcast booster station. (e) AM or FM radio... indicates otherwise. (f) FM broadcast booster station. A station in the broadcasting service operated for...

47 CFR 74.750 - Transmission system facilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Translator, and TV Booster Stations § 74.750 Transmission system facilities. (a) A low power TV, TV translator, or TV booster station shall operate with a transmitter that is either certificated for licensing... rebroadcasting TV booster transmitting equipment using a modulation process must meet the following requirements...

47 CFR 74.1201 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... FM Broadcast Booster Stations § 74.1201 Definitions. (a) FM translator. A station in the broadcasting... retransmitted by an FM broadcast translator station or an FM broadcast booster station. (e) AM or FM radio... indicates otherwise. (f) FM broadcast booster station. A station in the broadcasting service operated for...

47 CFR 74.1201 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FM Broadcast Booster Stations § 74.1201 Definitions. (a) FM translator. A station in the broadcasting... retransmitted by an FM broadcast translator station or an FM broadcast booster station. (e) AM or FM radio... indicates otherwise. (f) FM broadcast booster station. A station in the broadcasting service operated for...

Interventions for promoting booster seat use in four to eight year olds traveling in motor vehicles.

PubMed

Ehiri, J E; Ejere, H O D; Magnussen, L; Emusu, D; King, W; Osberg, J S

2006-01-25

Public health and traffic safety agencies recommend use of booster seats in motor vehicles for children aged four to eight years, and various interventions have been implemented to increase their use by individuals who transport children in motor vehicles. There is little evidence regarding the effectiveness of these interventions, hence the need to examine what works and what does not. To assess the effectiveness of interventions intended to increase acquisition and use of booster seats in motor vehicles among four to eight year olds. We searched the Cochrane Injuries Group's Specialized Register, the Cochrane Central Register of Controlled Trials, MEDLINE (January 1966 to April 2005), EMBASE (1980 to April 2005), LILACS, Transport Research Databases (1988 to April 2005), Australian Transport Index (1976 to April 2005), additional databases and reference lists of relevant articles. We also contacted experts in the field. We included randomized and controlled before-and-after trials that investigated the effects of interventions to promote booster seat use. Two authors independently assessed trial quality and extracted data. Study authors were contacted for additional information. Five studies involving 3,070 individuals met the criteria for inclusion in the meta-analysis. All interventions for promoting use of booster seats among 4 to 8 year olds demonstrated a positive effect (relative risk (RR) 1.43; 95% confidence intervals (CI) 1.05 to 1.96). Incentives combined with education demonstrated a beneficial effect (RR 1.32, 95% CI 1.12 to 1.55; n = 1,898). Distribution of free booster seats combined with education also had a beneficial effect (RR 2.34; 95% CI 1.50 to 3.63; n = 380) as did education-only interventions (RR 1.32; 95% CI 1.16 to 1.49; n = 563). One study which evaluated enforcement of booster seat law met the criteria for inclusion in the meta-analysis, but demonstrated no marked beneficial effect. Available evidence suggests that interventions to increase use of booster seats among children age four to eight years are effective. Combining incentives (booster seat discount coupons or gift certificates) or distribution of free booster seats with education demonstrated marked beneficial outcomes for acquisition and use of booster seats for four to eight year olds. There is some evidence of beneficial effect of legislation on acquisition and use of booster seats but this was mainly from uncontrolled before-and-after studies, which did not meet the criteria for inclusion in the meta-analysis.

Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

PubMed Central

Pateraki, Irini; Andersen-Ranberg, Johan; Jensen, Niels Bjerg; Wubshet, Sileshi Gizachew; Heskes, Allison Maree; Forman, Victor; Hallström, Björn; Hamberger, Britta; Motawia, Mohammed Saddik; Olsen, Carl Erik; Staerk, Dan; Hansen, Jørgen; Møller, Birger Lindberg; Hamberger, Björn

2017-01-01

Forskolin is a unique structurally complex labdane-type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic AMP booster. Commercial production of forskolin relies exclusively on extraction from its only known natural source, the plant Coleus forskohlii, in which forskolin accumulates in the root cork. Here, we report the discovery of five cytochrome P450s and two acetyltransferases which catalyze a cascade of reactions converting the forskolin precursor 13R-manoyl oxide into forskolin and a diverse array of additional labdane-type diterpenoids. A minimal set of three P450s in combination with a single acetyl transferase was identified that catalyzes the conversion of 13R-manoyl oxide into forskolin as demonstrated by transient expression in Nicotiana benthamiana. The entire pathway for forskolin production from glucose encompassing expression of nine genes was stably integrated into Saccharomyces cerevisiae and afforded forskolin titers of 40 mg/L. DOI: http://dx.doi.org/10.7554/eLife.23001.001 PMID:28290983

Fermi-LAT detection of increased gamma-ray activity from the FSRQ PKS 1004-217

NASA Astrophysics Data System (ADS)

Kreter, Michael

2018-03-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar (FSRQ) PKS 1004-217 (3FGL J1006.7-2159) with coordinates RA: 10h06m46.4136s, DEC: -21d59m20.410s, J2000 (Beasley et al. 2002, ApJS, 141, 13) and redshift z=0.331 (Hewitt & Burbidge 1989, ApJS, 69, 1). Preliminary analysis indicates that on 4 March 2018, this source was in a high-flux state with a daily averaged gamma-ray flux (E > 100MeV) of (0.84+/-0.08) X 10^-6 photons cm^-2 s^-1 (statistical uncertainties only).

Simulation of Swap-Out Reliability For The Advance Photon Source Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borland, M.

2017-06-01

The proposed upgrade of the Advanced Photon Source (APS) to a multibend-achromat lattice relies on the use of swap-out injection to accommodate the small dynamic acceptance, allow use of unusual insertion devices, and minimize collective effects at high single-bunch charge. This, combined with the short beam lifetime, will make injector reliability even more important than it is for top-up operation. We used historical data for the APS injector complex to obtain probability distributions for injector up-time and down-time durations. Using these distributions, we simulated several years of swap-out operation for the upgraded lattice for several operatingmodes. The results indicate thatmore » obtaining very high availability of beam in the storage ring will require improvements to injector reliability.« less

Fermi LAT detection of renewed GeV gamma-ray activity from the gravitationally lensed blazar PKS 1830-211

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2012-06-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with PKS 1830-211 (also known as 2FGL J1833.6-2104, Nolan et al. 2012, ApJS, 199, 31, placed at RA: 18h 33m 39.9s, Dec -21d 03m 40s, J2000, van Ommen et al., 1995, ApJ, 444, 561). PKS 1830-211 (z=2.507, Lovell et al. 1998, ApJ, 508, L51) is a distant and peculiar flat spectrum radio quasar with intervening absorption systems and being subject to gravitational lensing by a galaxy placed at z=0.886 (Wiklind & Combes 1996, Nature, 379, 11).

Thermal Modeling and Cryogenic Design of a Helical Superconducting Undulator Cryostat

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shiroyanagi, Y.; Fuerst, J.; Hasse, Q.

A conceptual design for a helical superconducting undulator (HSCU) for the Advanced Photon Source (APS) at Argonne National Laboratory (ANL) has been completed. The device differs sufficiently from the existing APS planar superconducting undulator (SCU) design to warrant development of a new cryostat based on value engineering and lessons learned from the existing planar SCU. Changes include optimization of the existing cryocooler-based refrigeration system and thermal shield as well as cost reduction through the use of standard vacuum hardware. The end result is a design that provides significantly larger 4.2 K refrigeration margin in a smaller package for greater installationmore » flexibility in the APS storage ring. This paper presents ANSYS-based thermal analysis of the cryostat, including estimated static and dynamic« less

Spacecraft hazard avoidance utilizing structured light

NASA Technical Reports Server (NTRS)

Liebe, Carl Christian; Padgett, Curtis; Chapsky, Jacob; Wilson, Daniel; Brown, Kenneth; Jerebets, Sergei; Goldberg, Hannah; Schroeder, Jeffrey

2006-01-01

At JPL, a <5 kg free-flying micro-inspector spacecraft is being designed for host-vehicle inspection. The spacecraft includes a hazard avoidance sensor to navigate relative to the vehicle being inspected. Structured light was selected for hazard avoidance because of its low mass and cost. Structured light is a method of remote sensing 3-dimensional structure of the proximity utilizing a laser, a grating, and a single regular APS camera. The laser beam is split into 400 different beams by a grating to form a regular spaced grid of laser beams that are projected into the field of view of an APS camera. The laser source and the APS camera are separated forming the base of a triangle. The distance to all beam intersections of the host are calculated based on triangulation.

Diatoms and diatomaceous earth as novel poultry vaccine adjuvants.

PubMed

Nazmi, A; Hauck, R; Davis, A; Hildebrand, M; Corbeil, L B; Gallardo, R A

2017-02-01

Diatoms are single cell eukaryotic microalgae; their surface possesses a porous nanostructured silica cell wall or frustule. Diatomaceous earth (DE) or diatomite is a natural siliceous sediment of diatoms. Since silica has been proved to have adjuvant capabilities, we propose that diatoms and DE may provide an inexpensive and abundant source of adjuvant readily available to use in livestock vaccines.In a first experiment, the safety of diatoms used as an adjuvant for in-ovo vaccination was investigated. In a second experiment, we assessed the humoral immune response after one in-ovo vaccination with inactivated Newcastle Disease Virus (NDV) and DE as adjuvant followed by 2 subcutaneous boosters on d 21 and 29 of age. In both experiments, results were compared to Freund's incomplete adjuvant and aluminum hydroxide.No detrimental effects on hatchability and chick quality were detected after in-ovo inoculation of diatoms and DE in experiments 1 and 2 respectively. In experiment 2 no humoral responses were detected after the in-ovo vaccination until 29 d of age. Seven d after the second subcutaneous booster an antibody response against NDV was detected in chickens that had received vaccines adjuvanted with Freund's incomplete adjuvant, aluminum hydroxide, and DE. These responses became significantly higher 10 d after the second booster. Finally, 15 d after the second booster, the humoral responses induced by the vaccine with Freund's incomplete adjuvant were statistically higher, followed by comparable responses induced by vaccines containing DE or aluminum hydroxide that were significantly higher than DE+PBS, PBS+INDV and PBS alone. From an applied perspective, we can propose that DE can serve as a potential adjuvant for vaccines against poultry diseases. Published by Oxford University Press on behalf of Poultry Science Association 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

75 FR 19567 - Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-15

...-AP80 Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR... changed our interpretation of the PSD and nonattainment NSR regulations relating to the definition of... Historic Approach Under both the nonattainment NSR provisions of the CAA as well as the PSD provisions, a...

75 FR 28227 - Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR): Aggregation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Parts 51 and 52 [EPA-HQ-OAR-2003-0064, FRL-9151-3] RIN 2060-AP80 Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR): Aggregation Correction Proposed Rule document 2010-11578 was inadvertently published in the Rules and...

The pattern space factor and quality factor of cylindrical source antennas

NASA Astrophysics Data System (ADS)

Jarem, John M.

1982-09-01

For the first time the quality factor of cylindrical source antennas is derived by a plane wave expansion. The evanescent energy (and therefore the quality factor) as defined by a plane wave expansion is shown to be different from Collin and Rothschild's [IEEE Trans. Antennas Propagation AP-12, 23 (1964)] quality factor.

Study of solid rocket motor for a space shuttle booster

NASA Technical Reports Server (NTRS)

1972-01-01

The study of solid rocket motors for a space shuttle booster was directed toward definition of a parallel-burn shuttle booster using two 156-in.-dia solid rocket motors. The study effort was organized into the following major task areas: system studies, preliminary design, program planning, and program costing.

47 CFR 74.761 - Frequency tolerance.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Booster Stations § 74.761 Frequency tolerance. The licensee of a low power TV, TV translator, or TV booster station shall maintain the transmitter output frequencies as set forth below. The frequency... channel carrier frequency if the low power TV, TV translator, or TV booster station is authorized with a...

47 CFR 74.1261 - Frequency tolerance.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FM Broadcast Booster Stations § 74.1261 Frequency tolerance. (a) The licensee of an FM translator or booster station with an authorized transmitter power output of 10 watts or less shall maintain the center... an FM translator or booster station with an authorized transmitter power output greater than 10 watts...

47 CFR 74.761 - Frequency tolerance.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Booster Stations § 74.761 Frequency tolerance. The licensee of a low power TV, TV translator, or TV booster station shall maintain the transmitter output frequencies as set forth below. The frequency... channel carrier frequency if the low power TV, TV translator, or TV booster station is authorized with a...

47 CFR 74.1231 - Purpose and permissible service.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Translator Stations and FM Broadcast Booster Stations § 74.1231 Purpose and permissible service. (a) FM... facilities to receive the signal that is being rebroadcast. An FM booster station or a noncommercial... used to deliver signals to FM translator and booster stations on a secondary basis only. Such use shall...

47 CFR 27.1236 - Self-transitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... station or booster serving each EBS receive site entitled to protection, including: (i) The make and model of the antenna for that main station or booster, along with the radiation pattern if it is not... building or antenna supporting structure on which the main station or booster transmission antenna is...

47 CFR 74.1263 - Time of operation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... FM Broadcast Booster Stations § 74.1263 Time of operation. (a) The licensee of an FM translator or booster station is not required to adhere to any regular schedule of operation. However, the licensee of an FM translator or booster station is expected to provide a dependable service to the extent that...

47 CFR 73.3521 - Mutually exclusive applications for low power television, television translators and television...

Code of Federal Regulations, 2013 CFR

2013-10-01

... television, television translators and television booster stations. 73.3521 Section 73.3521 Telecommunication..., television translators and television booster stations. When there is a pending application for a new low power television, television translator, or television booster station, or for major changes in an...

Meningococcal Vaccine (For Parents)

MedlinePlus

... are 11 or 12 years old, with a booster given at age 16 for teens 13–18 ... the ages of 13–15 should get a booster dose between the ages of 16–18. Teens ... those entering the military) won't need a booster dose. A full series of the meningococcal conjugate ...

47 CFR 74.1263 - Time of operation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FM Broadcast Booster Stations § 74.1263 Time of operation. (a) The licensee of an FM translator or booster station is not required to adhere to any regular schedule of operation. However, the licensee of an FM translator or booster station is expected to provide a dependable service to the extent that...

47 CFR 74.781 - Station records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Booster Stations § 74.781 Station records. (a) The licensee of a low power TV, TV translator, or TV booster station shall maintain adequate station records, including the current instrument of authorization... other suitable place, in one of the communities of license of the translator or booster, except that the...