Fukushima Daiichi reactor source term attribution using cesium isotope ratios from contaminated environmental samples

DOE PAGES

Snow, Mathew S.; Snyder, Darin C.; Delmore, James E.

2016-01-18

Source term attribution of environmental contamination following the Fukushima Daiichi Nuclear Power Plant (FDNPP) disaster is complicated by a large number of possible similar emission source terms (e.g. FDNPP reactor cores 1–3 and spent fuel ponds 1–4). Cesium isotopic analyses can be utilized to discriminate between environmental contamination from different FDNPP source terms and, if samples are sufficiently temporally resolved, potentially provide insights into the extent of reactor core damage at a given time. Rice, soil, mushroom, and soybean samples taken 100–250 km from the FDNPP site were dissolved using microwave digestion. Radiocesium was extracted and purified using two sequentialmore » ammonium molybdophosphate-polyacrylonitrile columns, following which 135Cs/ 137Cs isotope ratios were measured using thermal ionization mass spectrometry (TIMS). Results were compared with data reported previously from locations to the northwest of FDNPP and 30 km to the south of FDNPP. 135Cs/ 137Cs isotope ratios from samples 100–250 km to the southwest of the FDNPP site show a consistent value of 0.376 ± 0.008. 135Cs/ 137Cs versus 134Cs/ 137Cs correlation plots suggest that radiocesium to the southwest is derived from a mixture of FDNPP reactor cores 1, 2, and 3. Conclusions from the cesium isotopic data are in agreement with those derived independently based upon the event chronology combined with meteorological conditions at the time of the disaster. In conclusion, cesium isotopic analyses provide a powerful tool for source term discrimination of environmental radiocesium contamination at the FDNPP site. For higher precision source term attribution and forensic determination of the FDNPP core conditions based upon cesium, analyses of a larger number of samples from locations to the north and south of the FDNPP site (particularly time-resolved air filter samples) are needed. Published in 2016. This article is a U.S. Government work and is in the public domain in the USA.« less

Fukushima Daiichi reactor source term attribution using cesium isotope ratios from contaminated environmental samples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snow, Mathew S.; Snyder, Darin C.; Delmore, James E.

Source term attribution of environmental contamination following the Fukushima Daiichi Nuclear Power Plant (FDNPP) disaster is complicated by a large number of possible similar emission source terms (e.g. FDNPP reactor cores 1–3 and spent fuel ponds 1–4). Cesium isotopic analyses can be utilized to discriminate between environmental contamination from different FDNPP source terms and, if samples are sufficiently temporally resolved, potentially provide insights into the extent of reactor core damage at a given time. Rice, soil, mushroom, and soybean samples taken 100–250 km from the FDNPP site were dissolved using microwave digestion. Radiocesium was extracted and purified using two sequentialmore » ammonium molybdophosphate-polyacrylonitrile columns, following which 135Cs/ 137Cs isotope ratios were measured using thermal ionization mass spectrometry (TIMS). Results were compared with data reported previously from locations to the northwest of FDNPP and 30 km to the south of FDNPP. 135Cs/ 137Cs isotope ratios from samples 100–250 km to the southwest of the FDNPP site show a consistent value of 0.376 ± 0.008. 135Cs/ 137Cs versus 134Cs/ 137Cs correlation plots suggest that radiocesium to the southwest is derived from a mixture of FDNPP reactor cores 1, 2, and 3. Conclusions from the cesium isotopic data are in agreement with those derived independently based upon the event chronology combined with meteorological conditions at the time of the disaster. In conclusion, cesium isotopic analyses provide a powerful tool for source term discrimination of environmental radiocesium contamination at the FDNPP site. For higher precision source term attribution and forensic determination of the FDNPP core conditions based upon cesium, analyses of a larger number of samples from locations to the north and south of the FDNPP site (particularly time-resolved air filter samples) are needed. Published in 2016. This article is a U.S. Government work and is in the public domain in the USA.« less

Fukushima Daiichi reactor source term attribution using cesium isotope ratios from contaminated environmental samples.

PubMed

Snow, Mathew S; Snyder, Darin C; Delmore, James E

2016-02-28

Source term attribution of environmental contamination following the Fukushima Daiichi Nuclear Power Plant (FDNPP) disaster is complicated by a large number of possible similar emission source terms (e.g. FDNPP reactor cores 1-3 and spent fuel ponds 1-4). Cesium isotopic analyses can be utilized to discriminate between environmental contamination from different FDNPP source terms and, if samples are sufficiently temporally resolved, potentially provide insights into the extent of reactor core damage at a given time. Rice, soil, mushroom, and soybean samples taken 100-250 km from the FDNPP site were dissolved using microwave digestion. Radiocesium was extracted and purified using two sequential ammonium molybdophosphate-polyacrylonitrile columns, following which (135)Cs/(137) Cs isotope ratios were measured using thermal ionization mass spectrometry (TIMS). Results were compared with data reported previously from locations to the northwest of FDNPP and 30 km to the south of FDNPP. (135)Cs/(137)Cs isotope ratios from samples 100-250 km to the southwest of the FDNPP site show a consistent value of 0.376 ± 0.008. (135)Cs/(137)Cs versus (134)Cs/(137)Cs correlation plots suggest that radiocesium to the southwest is derived from a mixture of FDNPP reactor cores 1, 2, and 3. Conclusions from the cesium isotopic data are in agreement with those derived independently based upon the event chronology combined with meteorological conditions at the time of the disaster. Cesium isotopic analyses provide a powerful tool for source term discrimination of environmental radiocesium contamination at the FDNPP site. For higher precision source term attribution and forensic determination of the FDNPP core conditions based upon cesium, analyses of a larger number of samples from locations to the north and south of the FDNPP site (particularly time-resolved air filter samples) are needed. Published in 2016. This article is a U.S. Government work and is in the public domain in the USA.

Basic repository source term and data sheet report: Lavender Canyon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-01-01

This report is one of a series describing studies undertaken in support of the US Department of Energy Civilian Radioactive Waste Management (CRWM) Program. This study contains the derivation of values for environmental source terms and resources consumed for a CRWM repository. Estimates include heavy construction equipment; support equipment; shaft-sinking equipment; transportation equipment; and consumption of fuel, water, electricity, and natural gas. Data are presented for construction and operation at an assumed site in Lavender Canyon, Utah. 3 refs; 6 tabs.

A comparative mathematical analysis of RL and RC electrical circuits via Atangana-Baleanu and Caputo-Fabrizio fractional derivatives

NASA Astrophysics Data System (ADS)

Abro, Kashif Ali; Memon, Anwar Ahmed; Uqaili, Muhammad Aslam

2018-03-01

This research article is analyzed for the comparative study of RL and RC electrical circuits by employing newly presented Atangana-Baleanu and Caputo-Fabrizio fractional derivatives. The governing ordinary differential equations of RL and RC electrical circuits have been fractionalized in terms of fractional operators in the range of 0 ≤ ξ ≤ 1 and 0 ≤ η ≤ 1. The analytic solutions of fractional differential equations for RL and RC electrical circuits have been solved by using the Laplace transform with its inversions. General solutions have been investigated for periodic and exponential sources by implementing the Atangana-Baleanu and Caputo-Fabrizio fractional operators separately. The investigated solutions have been expressed in terms of simple elementary functions with convolution product. On the basis of newly fractional derivatives with and without singular kernel, the voltage and current have interesting behavior with several similarities and differences for the periodic and exponential sources.

Topological Hall effect in diffusive ferromagnetic thin films with spin-flip scattering

DOE PAGES

Zhang, Steven S. -L.; Heinonen, Olle

2018-04-02

In this paper, we study the topological Hall (TH) effect in a diffusive ferromagnetic metal thin film by solving a Boltzmann transport equation in the presence of spin-flip scattering. A generalized spin-diffusion equation is derived which contains an additional source term associated with the gradient of the emergent magnetic field that arises from skyrmions. Because of the source term, spin accumulation may build up in the vicinity of the skyrmions. This gives rise to a spin-polarized diffusion current that in general suppresses the bulk TH current. Only when the spin-diffusion length is much smaller than the skyrmion size does themore » TH resistivity approach the value derived by Bruno et al. [Phys. Rev. Lett. 93, 096806 (2004)]. Finally, we derive a general expression of the TH resistivity that applies to thin-film geometries with spin-flip scattering, and show that the corrections to the TH resistivity become large when the size of room temperature skyrmions is further reduced to tens of nanometers.« less

Topological Hall effect in diffusive ferromagnetic thin films with spin-flip scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Steven S. -L.; Heinonen, Olle

In this paper, we study the topological Hall (TH) effect in a diffusive ferromagnetic metal thin film by solving a Boltzmann transport equation in the presence of spin-flip scattering. A generalized spin-diffusion equation is derived which contains an additional source term associated with the gradient of the emergent magnetic field that arises from skyrmions. Because of the source term, spin accumulation may build up in the vicinity of the skyrmions. This gives rise to a spin-polarized diffusion current that in general suppresses the bulk TH current. Only when the spin-diffusion length is much smaller than the skyrmion size does themore » TH resistivity approach the value derived by Bruno et al. [Phys. Rev. Lett. 93, 096806 (2004)]. Finally, we derive a general expression of the TH resistivity that applies to thin-film geometries with spin-flip scattering, and show that the corrections to the TH resistivity become large when the size of room temperature skyrmions is further reduced to tens of nanometers.« less

Topological Hall effect in diffusive ferromagnetic thin films with spin-flip scattering

NASA Astrophysics Data System (ADS)

Zhang, Steven S.-L.; Heinonen, Olle

2018-04-01

We study the topological Hall (TH) effect in a diffusive ferromagnetic metal thin film by solving a Boltzmann transport equation in the presence of spin-flip scattering. A generalized spin-diffusion equation is derived which contains an additional source term associated with the gradient of the emergent magnetic field that arises from skyrmions. Because of the source term, spin accumulation may build up in the vicinity of the skyrmions. This gives rise to a spin-polarized diffusion current that in general suppresses the bulk TH current. Only when the spin-diffusion length is much smaller than the skyrmion size does the TH resistivity approach the value derived by Bruno et al. [Phys. Rev. Lett. 93, 096806 (2004), 10.1103/PhysRevLett.93.096806]. We derive a general expression of the TH resistivity that applies to thin-film geometries with spin-flip scattering, and show that the corrections to the TH resistivity become large when the size of room temperature skyrmions is further reduced to tens of nanometers.

EFFECTS OF LONG-TERM EXPOSURE TO TRAFFIC-DERIVED PARTICLES AND GASES ON SUBCLINICAL MEASURES OF CARDIOVASCULAR DISEASE IN A MULTI-ETHNIC COHORT

EPA Science Inventory

This project will transform MESA Air from its current focus on PM_2.5 into a multi-pollutant study that can meaningfully investigate the impact of traffic-derived air pollution on cardiovascular health using a source-to-exposure approach. We will integrate data on tr...

An Exact Form of Lilley's Equation with a Velocity Quadrupole/Temperature Dipole Source Term

NASA Technical Reports Server (NTRS)

Goldstein, Marvin E.

2001-01-01

There have been several attempts to introduce approximations into the exact form of Lilley's equation in order to express the source term as the sum of a quadrupole whose strength is quadratic in the fluctuating velocities and a dipole whose strength is proportional to the temperature fluctuations. The purpose of this note is to show that it is possible to choose the dependent (i.e., the pressure) variable so that this type of result can be derived directly from the Euler equations without introducing any additional approximations.

A time reversal algorithm in acoustic media with Dirac measure approximations

NASA Astrophysics Data System (ADS)

Bretin, Élie; Lucas, Carine; Privat, Yannick

2018-04-01

This article is devoted to the study of a photoacoustic tomography model, where one is led to consider the solution of the acoustic wave equation with a source term writing as a separated variables function in time and space, whose temporal component is in some sense close to the derivative of the Dirac distribution at t  =  0. This models a continuous wave laser illumination performed during a short interval of time. We introduce an algorithm for reconstructing the space component of the source term from the measure of the solution recorded by sensors during a time T all along the boundary of a connected bounded domain. It is based at the same time on the introduction of an auxiliary equivalent Cauchy problem allowing to derive explicit reconstruction formula and then to use of a deconvolution procedure. Numerical simulations illustrate our approach. Finally, this algorithm is also extended to elasticity wave systems.

Beyond the double banana: improved recognition of temporal lobe seizures in long-term EEG.

PubMed

Rosenzweig, Ivana; Fogarasi, András; Johnsen, Birger; Alving, Jørgen; Fabricius, Martin Ejler; Scherg, Michael; Neufeld, Miri Y; Pressler, Ronit; Kjaer, Troels W; van Emde Boas, Walter; Beniczky, Sándor

2014-02-01

To investigate whether extending the 10-20 array with 6 electrodes in the inferior temporal chain and constructing computed montages increases the diagnostic value of ictal EEG activity originating in the temporal lobe. In addition, the accuracy of computer-assisted spectral source analysis was investigated. Forty EEG samples were reviewed by 7 EEG experts in various montages (longitudinal and transversal bipolar, common average, source derivation, source montage, current source density, and reference-free montages) using 2 electrode arrays (10-20 and the extended one). Spectral source analysis used source montage to calculate density spectral array, defining the earliest oscillatory onset. From this, phase maps were calculated for localization. The reference standard was the decision of the multidisciplinary epilepsy surgery team on the seizure onset zone. Clinical performance was compared with the double banana (longitudinal bipolar montage, 10-20 array). Adding the inferior temporal electrode chain, computed montages (reference free, common average, and source derivation), and voltage maps significantly increased the sensitivity. Phase maps had the highest sensitivity and identified ictal activity at earlier time-point than visual inspection. There was no significant difference concerning specificity. The findings advocate for the use of these digital EEG technology-derived analysis methods in clinical practice.

Use of collagen hydrolysate as a complex nitrogen source for the synthesis of penicillin by Penicillium chrysogenum.

PubMed

Leonhartsberger, S; Lafferty, R M; Korneti, L

1993-09-01

Optimal conditions for both biomass formation and penicillin synthesis by a strain of Penicillium chrysogenum were determined when using a collagen-derived nitrogen source. Preliminary investigations were carried out in shaken flask cultures employing a planned experimental program termed the Graeco-Latin square technique (Auden et al., 1967). It was initially determined that up to 30% of a conventional complex nitrogen source such as cottonseed meal could be replaced by the collagen-derived nitrogen source without decreasing the productivity with respect to the penicillin yield. In the pilot scale experiments using a 30 l stirred tank type of bioreactor, higher penicillin yields were obtained when 70% of the conventional complex nitrogen source in the form of cottonseed meal was replaced by the collagen hydrolysate. Furthermore, the maximum rate of penicillin synthesis continued for over a longer period when using collagen hydrolysate as a complex nitrogen source. Penicillin synthesis rates were determined using a linear regression.

Liquefaction of Saturated Soil and the Diffusion Equation

NASA Astrophysics Data System (ADS)

Sawicki, Andrzej; Sławińska, Justyna

2015-06-01

The paper deals with the diffusion equation for pore water pressures with the source term, which is widely promoted in the marine engineering literature. It is shown that such an equation cannot be derived in a consistent way from the mass balance and the Darcy law. The shortcomings of the artificial source term are pointed out, including inconsistencies with experimental data. It is concluded that liquefaction and the preceding process of pore pressure generation and the weakening of the soil skeleton should be described by constitutive equations within the well-known framework of applied mechanics. Relevant references are provided

Mantle heterogeneity and crustal recycling in Archean granite-greenstone belts - Evidence from Nd isotopes and trace elements in the Rainy Lake area, Superior Province, Ontario, Canada

NASA Technical Reports Server (NTRS)

Shirey, Steven B.; Hanson, Gilbert N.

1986-01-01

Crustal evolution in the Rainy Lake area, Ontario is studied in terms of geochemical characteristics. The Nd isotope data are examined for heterogeneity of the Archean mantle, and the Sm/Nd depletion of the mantle is analyzed. The Nd isotope systematics of individual rock suites is investigated in order to understand the difference between crust and mantle sources; the precursors and petrogenetic processes are discussed. The correlation between SiO2 content and Nd values is considered. Rapid recycling of crustal components, which were previously derived from depleted mantle sources, is suggested based on the similarity of the initial Nd isotopic composition for both mantle-derived and crustally-derived rocks.

Poisson equation for the three-loop ladder diagram in string theory at genus one

NASA Astrophysics Data System (ADS)

Basu, Anirban

2016-11-01

The three-loop ladder diagram is a graph with six links and four cubic vertices that contributes to the D12ℛ4 amplitude at genus one in type II string theory. The vertices represent the insertion points of vertex operators on the toroidal worldsheet and the links represent scalar Green functions connecting them. By using the properties of the Green function and manipulating the various expressions, we obtain a modular invariant Poisson equation satisfied by this diagram, with source terms involving one-, two- and three-loop diagrams. Unlike the source terms in the Poisson equations for diagrams at lower orders in the momentum expansion or the Mercedes diagram, a particular source term involves a five-point function containing a holomorphic and a antiholomorphic worldsheet derivative acting on different Green functions. We also obtain simple equalities between topologically distinct diagrams, and consider some elementary examples.

Alternative uses of highway rights-of-way : accommodating renewable energy technologies

DOT National Transportation Integrated Search

2012-01-01

In recent years, the capacity, generation, and consumption of energy derived from renewable sources have grown significantly on a global level. To increase renewable energy production in the near term, state and local transportation agencies have rec...

High-order flux correction/finite difference schemes for strand grids

NASA Astrophysics Data System (ADS)

Katz, Aaron; Work, Dalon

2015-02-01

A novel high-order method combining unstructured flux correction along body surfaces and high-order finite differences normal to surfaces is formulated for unsteady viscous flows on strand grids. The flux correction algorithm is applied in each unstructured layer of the strand grid, and the layers are then coupled together via a source term containing derivatives in the strand direction. Strand-direction derivatives are approximated to high-order via summation-by-parts operators for first derivatives and second derivatives with variable coefficients. We show how this procedure allows for the proper truncation error canceling properties required for the flux correction scheme. The resulting scheme possesses third-order design accuracy, but often exhibits fourth-order accuracy when higher-order derivatives are employed in the strand direction, especially for highly viscous flows. We prove discrete conservation for the new scheme and time stability in the absence of the flux correction terms. Results in two dimensions are presented that demonstrate improvements in accuracy with minimal computational and algorithmic overhead over traditional second-order algorithms.

High-Order Residual-Distribution Hyperbolic Advection-Diffusion Schemes: 3rd-, 4th-, and 6th-Order

NASA Technical Reports Server (NTRS)

Mazaheri, Alireza R.; Nishikawa, Hiroaki

2014-01-01

In this paper, spatially high-order Residual-Distribution (RD) schemes using the first-order hyperbolic system method are proposed for general time-dependent advection-diffusion problems. The corresponding second-order time-dependent hyperbolic advection- diffusion scheme was first introduced in [NASA/TM-2014-218175, 2014], where rapid convergences over each physical time step, with typically less than five Newton iterations, were shown. In that method, the time-dependent hyperbolic advection-diffusion system (linear and nonlinear) was discretized by the second-order upwind RD scheme in a unified manner, and the system of implicit-residual-equations was solved efficiently by Newton's method over every physical time step. In this paper, two techniques for the source term discretization are proposed; 1) reformulation of the source terms with their divergence forms, and 2) correction to the trapezoidal rule for the source term discretization. Third-, fourth, and sixth-order RD schemes are then proposed with the above techniques that, relative to the second-order RD scheme, only cost the evaluation of either the first derivative or both the first and the second derivatives of the source terms. A special fourth-order RD scheme is also proposed that is even less computationally expensive than the third-order RD schemes. The second-order Jacobian formulation was used for all the proposed high-order schemes. The numerical results are then presented for both steady and time-dependent linear and nonlinear advection-diffusion problems. It is shown that these newly developed high-order RD schemes are remarkably efficient and capable of producing the solutions and the gradients to the same order of accuracy of the proposed RD schemes with rapid convergence over each physical time step, typically less than ten Newton iterations.

Thermal electron heating rate: A derivation

NASA Technical Reports Server (NTRS)

Hoegy, W. R.

1983-01-01

The thermal electron heating rate is an important heat source term in the ionospheric electron energy balance equation, representing heating by photoelectrons or by precipitating higher energy electrons. A formula for the thermal electron heating rate is derived from the kinetic equation using the electron-electron collision operator as given by the unified theory of Kihara and Aono. This collision operator includes collective interactions to produce a finite collision operator with an exact Coulomb logarithm term. The derived heating rate O(e) is the sum of three terms, O(e) = O(p) + S + O(int), which are respectively: (1) primary electron production term giving the heating from newly created electrons that have not yet suffered collisions with the ambient electrons; (2) a heating term evaluated on the energy surface m(e)/2 = E(T) at the transition between Maxwellian and tail electrons at E(T); and (3) the integral term representing heating of Maxwellian electrons by energetic tail electrons at energies ET. Published ionospheric electron temperature studies used only the integral term O(int) with differing lower integration limits. Use of the incomplete heating rate could lead to erroneous conclusions regarding electron heat balance, since O(e) is greater than O(int) by as much as a factor of two.

Second-harmonic generation in shear wave beams with different polarizations

NASA Astrophysics Data System (ADS)

Spratt, Kyle S.; Ilinskii, Yurii A.; Zabolotskaya, Evgenia A.; Hamilton, Mark F.

2015-10-01

A coupled pair of nonlinear parabolic equations was derived by Zabolotskaya [1] that model the transverse components of the particle motion in a collimated shear wave beam propagating in an isotropic elastic solid. Like the KZK equation, the parabolic equation for shear wave beams accounts consistently for the leading order effects of diffraction, viscosity and nonlinearity. The nonlinearity includes a cubic nonlinear term that is equivalent to that present in plane shear waves, as well as a quadratic nonlinear term that is unique to diffracting beams. The work by Wochner et al. [2] considered shear wave beams with translational polarizations (linear, circular and elliptical), wherein second-order nonlinear effects vanish and the leading order nonlinear effect is third-harmonic generation by the cubic nonlinearity. The purpose of the current work is to investigate the quadratic nonlinear term present in the parabolic equation for shear wave beams by considering second-harmonic generation in Gaussian beams as a second-order nonlinear effect using standard perturbation theory. In order for second-order nonlinear effects to be present, a broader class of source polarizations must be considered that includes not only the familiar translational polarizations, but also polarizations accounting for stretching, shearing and rotation of the source plane. It is found that the polarization of the second harmonic generated by the quadratic nonlinearity is not necessarily the same as the polarization of the source-frequency beam, and we are able to derive a general analytic solution for second-harmonic generation from a Gaussian source condition that gives explicitly the relationship between the polarization of the source-frequency beam and the polarization of the second harmonic.

Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications.

PubMed

Moraghebi, Roksana; Kirkeby, Agnete; Chaves, Patricia; Rönn, Roger E; Sitnicka, Ewa; Parmar, Malin; Larsson, Marcus; Herbst, Andreas; Woods, Niels-Bjarne

2017-08-25

Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of these cells in disease modelling, pharmaceutical screening, and regenerative medicine by applying reprogramming technologies. However, the limited availability of MSCs from various sources restricts their use. Term amniotic fluid has been proposed as an alternative source of MSCs. Previously, only low volumes of term fluid and its cellular constituents have been collected, and current knowledge of the MSCs derived from this fluid is limited. In this study, we collected amniotic fluid at term using a novel collection system and evaluated amniotic fluid MSC content and their characteristics, including their feasibility to undergo cellular reprogramming. Amniotic fluid was collected at term caesarean section deliveries using a closed catheter-based system. Following fluid processing, amniotic fluid was assessed for cellularity, MSC frequency, in-vitro proliferation, surface phenotype, differentiation, and gene expression characteristics. Cells were also reprogrammed to the pluripotent stem cell state and differentiated towards neural and haematopoietic lineages. The average volume of term amniotic fluid collected was approximately 0.4 litres per donor, containing an average of 7 million viable mononuclear cells per litre, and a CFU-F content of 15 per 100,000 MNCs. Expanded CFU-F cultures showed similar surface phenotype, differentiation potential, and gene expression characteristics to MSCs isolated from traditional sources, and showed extensive expansion potential and rapid doubling times. Given the high proliferation rates of these neonatal source cells, we assessed them in a reprogramming application, where the derived induced pluripotent stem cells showed multigerm layer lineage differentiation potential. The potentially large donor base from caesarean section deliveries, the high yield of term amniotic fluid MSCs obtainable, the properties of the MSCs identified, and the suitability of the cells to be reprogrammed into the pluripotent state demonstrated these cells to be a promising and plentiful resource for further evaluation in bio-banking, cell therapy, disease modelling, and regenerative medicine applications.

X-Ray Emission from Compact Sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cominsky, L

2004-03-23

This paper presents a review of the physical parameters of neutron stars and black holes that have been derived from X-ray observations. I then explain how these physical parameters can be used to learn about the extreme conditions occurring in regions of strong gravity, and present some recent evidence for relativistic effects seen in these systems. A glossary of commonly used terms and a short tutorial on the names of X-ray sources are also included.

Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomar, Geetanjali B.; Srivastava, Rupesh K.; Gupta, Navita

2010-03-12

Mesenchymal stem cells (MSCs) are capable of self-renewal and differentiation into multiple cell lineages. Presently, bone marrow is considered as a prime source of MSCs; however, there are some drawbacks and limitations in use of these MSCs for cell therapy. In this study, we demonstrate that human gingival tissue-derived MSCs have several advantages over bone marrow-derived MSCs. Gingival MSCs are easy to isolate, homogenous and proliferate faster than bone marrow MSCs without any growth factor. Importantly, gingival MSCs display stable morphology and do not loose MSC characteristic at higher passages. In addition, gingival MSCs maintain normal karyotype and telomerase activitymore » in long-term cultures, and are not tumorigenic. Thus, we reveal that human gingiva is a better source of MSCs than bone marrow, and large number of functionally competent clinical grade MSCs can be generated in short duration for cell therapy in regenerative medicine and tissue engineering.« less

How organic carbon derived from multiple sources contributes to carbon sequestration processes in a shallow coastal system?

PubMed Central

Watanabe, Kenta; Kuwae, Tomohiro

2015-01-01

Carbon captured by marine organisms helps sequester atmospheric CO2, especially in shallow coastal ecosystems, where rates of primary production and burial of organic carbon (OC) from multiple sources are high. However, linkages between the dynamics of OC derived from multiple sources and carbon sequestration are poorly understood. We investigated the origin (terrestrial, phytobenthos derived, and phytoplankton derived) of particulate OC (POC) and dissolved OC (DOC) in the water column and sedimentary OC using elemental, isotopic, and optical signatures in Furen Lagoon, Japan. Based on these data analysis, we explored how OC from multiple sources contributes to sequestration via storage in sediments, water column sequestration, and air–sea CO2 exchanges, and analyzed how the contributions vary with salinity in a shallow seagrass meadow as well. The relative contribution of terrestrial POC in the water column decreased with increasing salinity, whereas autochthonous POC increased in the salinity range 10–30. Phytoplankton-derived POC dominated the water column POC (65–95%) within this salinity range; however, it was minor in the sediments (3–29%). In contrast, terrestrial and phytobenthos-derived POC were relatively minor contributors in the water column but were major contributors in the sediments (49–78% and 19–36%, respectively), indicating that terrestrial and phytobenthos-derived POC were selectively stored in the sediments. Autochthonous DOC, part of which can contribute to long-term carbon sequestration in the water column, accounted for >25% of the total water column DOC pool in the salinity range 15–30. Autochthonous OC production decreased the concentration of dissolved inorganic carbon in the water column and thereby contributed to atmospheric CO2 uptake, except in the low-salinity zone. Our results indicate that shallow coastal ecosystems function not only as transition zones between land and ocean but also as carbon sequestration filters. They function at different timescales, depending on the salinity, and OC sources. PMID:25880367

An extension of the Lighthill theory of jet noise to encompass refraction and shielding

NASA Technical Reports Server (NTRS)

Ribner, Herbert S.

1995-01-01

A formalism for jet noise prediction is derived that includes the refractive 'cone of silence' and other effects; outside the cone it approximates the simple Lighthill format. A key step is deferral of the simplifying assumption of uniform density in the dominant 'source' term. The result is conversion to a convected wave equation retaining the basic Lighthill source term. The main effect is to amend the Lighthill solution to allow for refraction by mean flow gradients, achieved via a frequency-dependent directional factor. A general formula for power spectral density emitted from unit volume is developed as the Lighthill-based value multiplied by a squared 'normalized' Green's function (the directional factor), referred to a stationary point source. The convective motion of the sources, with its powerful amplifying effect, also directional, is already accounted for in the Lighthill format: wave convection and source convection are decoupled. The normalized Green's function appears to be near unity outside the refraction dominated 'cone of silence', this validates our long term practice of using Lighthill-based approaches outside the cone, with extension inside via the Green's function. The function is obtained either experimentally (injected 'point' source) or numerically (computational aeroacoustics). Approximation by unity seems adequate except near the cone and except when there are shrouding jets: in that case the difference from unity quantifies the shielding effect. Further extension yields dipole and monopole source terms (cf. Morfey, Mani, and others) when the mean flow possesses density gradients (e.g., hot jets).

Is Statewide Deinstitutionalization of Children's Services a Forward or Backward Social Movement?

ERIC Educational Resources Information Center

Thomas, George

Reviewed is the movement toward deinstitutionalization of handicapped children in terms of the sources of pressures toward deinstitutionalization, alternatives, effects of institutional experience on children, and possible consequences of the movement. Pressures discussed are those deriving from the assumed negative effects of institutionalization…

Glucose responsive insulin production from human embryonic germ (EG) cell derivatives.

PubMed

Clark, Gregory O; Yochem, Robert L; Axelman, Joyce; Sheets, Timothy P; Kaczorowski, David J; Shamblott, Michael J

2007-05-11

Type 1 diabetes mellitus subjects millions to a daily burden of disease management, life threatening hypoglycemia and long-term complications such as retinopathy, nephropathy, heart disease, and stroke. Cell transplantation therapies providing a glucose-regulated supply of insulin have been implemented clinically, but are limited by safety, efficacy and supply considerations. Stem cells promise a plentiful and flexible source of cells for transplantation therapies. Here, we show that cells derived from human embryonic germ (EG) cells express markers of definitive endoderm, pancreatic and beta-cell development, glucose sensing, and production of mature insulin. These cells integrate functions necessary for glucose responsive regulation of preproinsulin mRNA and expression of insulin C-peptide in vitro. Following transplantation into mice, cells become insulin and C-peptide immunoreactive and produce plasma C-peptide in response to glucose. These findings suggest that EG cell derivatives may eventually serve as a source of insulin producing cells for the treatment of diabetes.

Preparing aircraft propulsion for a new era in energy and the environment

NASA Technical Reports Server (NTRS)

Stewart, W. L.; Nored, D. L.; Grobman, J. S.; Feiler, C. E.; Petrash, D. A.

1980-01-01

Improving fuel efficiency, new sources of jet fuel, and noise and emission control are subjects of NASA's aeronautics program. Projects aimed at attaining a 5% fuel savings for existing engines and a 13-22% savings for the next generation of turbofan engines using advanced components, and establishing a basis for turboprop-powered commercial air transports with 30-40% savings over conventional turbofan aircraft at comparable speeds and altitudes, are discussed. Fuel sources are considered in terms of reduced hydrogen and higher aromatic contents and resultant higher liner temperatures, and attention is given to lean burning, improved fuel atomization, higher freezing-point fuel, and deriving jet fuel from shale oil or coal. Noise sources including the fan, turbine, combustion process, and flow over internal struts, and attenuation using acoustic treatment, are discussed, while near-term reduction of polluting gaseous emissions at both low and high power, and far-term defining of the minimum gaseous-pollutant levels possible from turbine engines are also under study.

Rainfall-runoff response informed by exact solutions of Boussinesq equation on hillslopes

NASA Astrophysics Data System (ADS)

Bartlett, M. S., Jr.; Porporato, A. M.

2017-12-01

The Boussinesq equation offers a powerful approach forunderstanding the flow dynamics of unconfined aquifers. Though this nonlinear equation allows for concise representation of both soil and geomorphological controls on groundwater flow, it has only been solved exactly for a limited number of initial and boundary conditions. These solutions do not include source/sink terms (evapotranspiration, recharge, and seepage to bedrock) and are typically limited to horizontal aquifers. Here we present a class of exact solutions that are general to sloping aquifers and a time varying source/sink term. By incorporating the source/sink term, they may describe aquifers with both time varying recharge over seasonal or weekly time scales, as well as a loss of water from seepage to the bedrock interface, which is a common feature in hillslopes. These new solutions shed light on the hysteretic relationship between streamflow and groundwater and the behavior of the hydrograph recession curves, thus providing a robust basis for deriving a runoff curves for the partition of rainfall into infiltration and runoff.

Open-Source Assisted Laboratory Automation through Graphical User Interfaces and 3D Printers: Application to Equipment Hyphenation for Higher-Order Data Generation.

PubMed

Siano, Gabriel G; Montemurro, Milagros; Alcaráz, Mirta R; Goicoechea, Héctor C

2017-10-17

Higher-order data generation implies some automation challenges, which are mainly related to the hidden programming languages and electronic details of the equipment. When techniques and/or equipment hyphenation are the key to obtaining higher-order data, the required simultaneous control of them demands funds for new hardware, software, and licenses, in addition to very skilled operators. In this work, we present Design of Inputs-Outputs with Sikuli (DIOS), a free and open-source code program that provides a general framework for the design of automated experimental procedures without prior knowledge of programming or electronics. Basically, instruments and devices are considered as nodes in a network, and every node is associated both with physical and virtual inputs and outputs. Virtual components, such as graphical user interfaces (GUIs) of equipment, are handled by means of image recognition tools provided by Sikuli scripting language, while handling of their physical counterparts is achieved using an adapted open-source three-dimensional (3D) printer. Two previously reported experiments of our research group, related to fluorescence matrices derived from kinetics and high-performance liquid chromatography, were adapted to be carried out in a more automated fashion. Satisfactory results, in terms of analytical performance, were obtained. Similarly, advantages derived from open-source tools assistance could be appreciated, mainly in terms of lesser intervention of operators and cost savings.

TECHNICAL MANPOWER IN NEW YORK STATE. VOLUME I.

ERIC Educational Resources Information Center

PEARCE, C.A.; AND OTHERS

GROUPS OF TECHNICAL OCCUPATIONS ARE COMPARED IN TERMS OF CHARACTERISTICS OF EMPLOYMENT, SOURCE OF WORKERS, AND EDUCATIONAL AND EXPERIENCE REQUIREMENTS. SURVEY FINDINGS ARE GIVEN FOR EMPLOYER TRAINING PROGRAMS AND EMPLOYER VIEWS AND POLICIES ON THE UTILIZATION OF TECHNICIANS. THE SURVEY DATA WERE DERIVED FROM A SAMPLE OF 17,414 ESTABLISHMENTS…

Long-term physical and oxidative stability of liposomes containing glycerides of lipoic acid

USDA-ARS?s Scientific Manuscript database

The acyl glycerides of lipoic and dihydrolipoic acids may serve as slow-release sources for cutaneous delivery of these antioxidants when formulated in a liposomal vehicle. Accelerated storage testing was conducted to determine the storage stability of the lipoic derivatives and of the soybean phosp...

On butterfly effect in higher derivative gravities

NASA Astrophysics Data System (ADS)

Alishahiha, Mohsen; Davody, Ali; Naseh, Ali; Taghavi, Seyed Farid

2016-11-01

We study butterfly effect in D-dimensional gravitational theories containing terms quadratic in Ricci scalar and Ricci tensor. One observes that due to higher order derivatives in the corresponding equations of motion there are two butterfly velocities. The velocities are determined by the dimension of operators whose sources are provided by the metric. The three dimensional TMG model is also studied where we get two butterfly velocities at generic point of the moduli space of parameters. At critical point two velocities coincide.

Tests of general relativity in earth orbit using a superconducting gravity gradiometer

NASA Technical Reports Server (NTRS)

Paik, H. J.

1989-01-01

Interesting new tests of general relativity could be performed in earth orbit using a sensitive superconducting gravity gradiometer under development. Two such experiments are discussed here: a null test of the tracelessness of the Riemann tensor and detection of the Lense-Thirring term in the earth's gravity field. The gravity gradient signals in various spacecraft orientations are derived, and dominant error sources in each experimental setting are discussed. The instrument, spacecraft, and orbit requirements imposed by the experiments are derived.

Ultraviolet and visible variability of the coma of Comet Levy (1990c)

NASA Technical Reports Server (NTRS)

Feldman, P. D.; Budzien, S. A.; Festou, M. C.; A'Hearn, M. F.; Tozzi, G. P.

1992-01-01

A visible lightcurve of Comet Levy obtained with the IUE Fine Error Sensor has revealed short-term coma variability. A production-rate source function is derivable from these data which implies a nucleus exhibiting hemispherically asymmetric activity. The ratio of gas-to-dust-production rates is also noted to exhibit asymmetry. The low dust-outflow velocity derived from observations, at about 200 m/sec, indicates a distribution that is rich in large, 3-10 micron particles.

Natural convection in symmetrically heated vertical parallel plates with discrete heat sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manca, O.; Nardini, S.; Naso, V.

Laminar air natural convection in a symmetrically heated vertical channel with uniform flush-mounted discrete heat sources has been experimentally investigated. The effects of heated strips location and of their number are pointed out in terms of the maximum wall temperatures. A flow visualization in the entrance region of the channel was carried out and air temperatures and velocities in two cross sections have been measured. Dimensionless local heat transfer coefficients have been evaluated and monomial correlations among relevant parameters have bee derived in the local Rayleigh number range 10--10{sup 6}. Channel Nusselt number has been correlated in a polynomial formmore » in terms of channel Rayleigh number.« less

Thermal maturity of type II kerogen from the New Albany Shale assessed by13C CP/MAS NMR

USGS Publications Warehouse

Werner-Zwanziger, U.; Lis, G.; Mastalerz, Maria; Schimmelmann, A.

2005-01-01

Thermal maturity of oil and gas source rocks is typically quantified in terms of vitrinite reflectance, which is based on optical properties of terrestrial woody remains. This study evaluates 13C CP/MAS NMR parameters in kerogen (i.e., the insoluble fraction of organic matter in sediments and sedimentary rocks) as proxies for thermal maturity in marine-derived source rocks where terrestrially derived vitrinite is often absent or sparse. In a suite of samples from the New Albany Shale (Middle Devonian to the Early Mississippian, Illinois Basin) the abundance of aromatic carbon in kerogen determined by 13C CP/MAS NMR correlates linearly well with vitrinite reflectance. ?? 2004 Elsevier Inc. All rights reserved.

Prospective Surface Marker-Based Isolation and Expansion of Fetal Endothelial Colony-Forming Cells From Human Term Placenta

PubMed Central

Patel, Jatin; Seppanen, Elke; Chong, Mark S.K.; Yeo, Julie S.L.; Teo, Erin Y.L.; Chan, Jerry K.Y.; Fisk, Nicholas M.

2013-01-01

The term placenta is a highly vascularized tissue and is usually discarded upon birth. Our objective was to isolate clinically relevant quantities of fetal endothelial colony-forming cells (ECFCs) from human term placenta and to compare them to the well-established donor-matched umbilical cord blood (UCB)-derived ECFCs. A sorting strategy was devised to enrich for CD45−CD34+CD31Lo cells prior to primary plating to obtain pure placental ECFCs (PL-ECFCs) upon culture. UCB-ECFCs were derived using a well-described assay. PL-ECFCs were fetal in origin and expressed the same cell surface markers as UCB-ECFCs. Most importantly, a single term placenta could yield as many ECFCs as 27 UCB donors. PL-ECFCs and UCB-ECFCs had similar in vitro and in vivo vessel forming capacities and restored mouse hind limb ischemia in similar proportions. Gene expression profiles were only minimally divergent between PL-ECFCs and UCB-ECFCs, probably reflecting a vascular source versus a circulating source. Finally, PL-ECFCs and UCB-ECFCs displayed similar hierarchies between high and low proliferative colonies. We report a robust strategy to isolate ECFCs from human term placentas based on their cell surface expression. This yielded much larger quantities of ECFCs than UCB, but the cells were comparable in immunophenotype, gene expression, and in vivo functional ability. We conclude that PL-ECFCs have significant bio-banking and clinical translatability potential. PMID:24106336

Assessing Pyrite-Derived Sulfate in the Mississippi River with Four Years of Sulfur and Triple-Oxygen Isotope Data.

PubMed

Killingsworth, Bryan A; Bao, Huiming; Kohl, Issaku E

2018-05-17

Riverine dissolved sulfate (SO 4 2- ) sulfur and oxygen isotope variations reflect their controls such as SO 4 2- reduction and reoxidation, and source mixing. However, unconstrained temporal variability of riverine SO 4 2- isotope compositions due to short sampling durations may lead to mischaracterization of SO 4 2- sources, particularly for the pyrite-derived sulfate load. We measured the sulfur and triple-oxygen isotopes (δ 34 S, δ 18 O, and Δ' 17 O) of Mississippi River SO 4 2- with biweekly sampling between 2009 and 2013 to test isotopic variability and constrain sources. Sulfate δ 34 S and δ 18 O ranged from -6.3‰ to -0.2‰ and -3.6‰ to +8.8‰, respectively. Our sampling period captured the most severe flooding and drought in the Mississippi River basin since 1927 and 1956, respectively, and a first year of sampling that was unrepresentative of long-term average SO 4 2- . The δ 34 S SO4 data indicate pyrite-derived SO 4 2- sources are 74 ± 10% of the Mississippi River sulfate budget. Furthermore, pyrite oxidation is implicated as the dominant process supplying SO 4 2- to the Mississippi River, whereas the Δ' 17 O SO4 data shows 18 ± 9% of oxygen in this sulfate is sourced from air O 2 .

The Role of Soft Power in China’s Security Strategy: Case Studies on the South China Sea and Taiwan

DTIC Science & Technology

2017-06-09

of power. The study also shows that the interplay between soft and hard power varies significantly depending on the context. 15. SUBJECT TERMS China...sources of power. The study also shows that the interplay between soft and hard power varies significantly depending on the context. v...policies.12 Nye qualifies that the magnitude of soft power that is derived from these sources is situationally dependent . For example, political values

The pyroelectric properties of TGS for application in infrared detection

NASA Technical Reports Server (NTRS)

Kroes, R. L.; Reiss, D.

1981-01-01

The pyroelectric property of triglycine sulfate and its application in the detection of infrared radiation are described. The detectivities of pyroelectric detectors and other types of infrared detectors are compared. The thermal response of a pyroelectric detector element and the resulting electrical response are derived in terms of the material parameters. The noise sources which limit the sensitivity of pyroelectric detectors are described, and the noise equivalent power for each noise source is given as a function of frequency and detector area.

Noise-enhanced CVQKD with untrusted source

NASA Astrophysics Data System (ADS)

Wang, Xiaoqun; Huang, Chunhui

2017-06-01

The performance of one-way and two-way continuous variable quantum key distribution (CVQKD) protocols can be increased by adding some noise on the reconciliation side. In this paper, we propose to add noise at the reconciliation end to improve the performance of CVQKD with untrusted source. We derive the key rate of this case and analyze the impact of the additive noise. The simulation results show that the optimal additive noise can improve the performance of the system in terms of maximum transmission distance and tolerable excess noise.

General analytical solutions for DC/AC circuit-network analysis

NASA Astrophysics Data System (ADS)

Rubido, Nicolás; Grebogi, Celso; Baptista, Murilo S.

2017-06-01

In this work, we present novel general analytical solutions for the currents that are developed in the edges of network-like circuits when some nodes of the network act as sources/sinks of DC or AC current. We assume that Ohm's law is valid at every edge and that charge at every node is conserved (with the exception of the source/sink nodes). The resistive, capacitive, and/or inductive properties of the lines in the circuit define a complex network structure with given impedances for each edge. Our solution for the currents at each edge is derived in terms of the eigenvalues and eigenvectors of the Laplacian matrix of the network defined from the impedances. This derivation also allows us to compute the equivalent impedance between any two nodes of the circuit and relate it to currents in a closed circuit which has a single voltage generator instead of many input/output source/sink nodes. This simplifies the treatment that could be done via Thévenin's theorem. Contrary to solving Kirchhoff's equations, our derivation allows to easily calculate the redistribution of currents that occurs when the location of sources and sinks changes within the network. Finally, we show that our solutions are identical to the ones found from Circuit Theory nodal analysis.

Fatty acid-based formulations for wood protection against mold and sapstain

Treesearch

Carol A. Clausen; Robert D. Coleman; Vina W. Yang

2010-01-01

Safer, highly effective biocides providing long-term protection of mold growth on wood-based materials is of interest to the wood protection industry. Moldicide formulations containing synergistic combinations of ingredients derived from natural sources are commonly recognized as a promising approach for the next generation of wood protectants. Although fatty acid (FA...

Reducing DoD Fossil-Fuel Dependence

DTIC Science & Technology

2006-09-01

hour: the amount of energy available from one gigawatt in one hour. HFCS High - fructose corn syrup HHV High -heat value HICE Hydrogen internal combustion...63 Ethanol derived from corn .................................................... 63...particular, alternate fuels and energy sources are to be assessed in terms of multiple parameters, to include (but not limited to) stability, high & low

Complaints against Nursing Homes: Comparing Two Sources of Complaint Information and Predictors of Complaints

ERIC Educational Resources Information Center

Troyer, Jennifer L.; Sause, Wendy L.

2011-01-01

Purpose of the Study: Two consumer-derived measures of nursing home quality that have been underutilized by researchers are consumer complaints to the state certification agency between inspections and complaints to the Long-Term Care Ombudsman Program. This article describes these complaints, considers facility-level predictors of complaints, and…

Perturbations of the seismic reflectivity of a fluid-saturated depth-dependent poroelastic medium.

PubMed

de Barros, Louis; Dietrich, Michel

2008-03-01

Analytical formulas are derived to compute the first-order effects produced by plane inhomogeneities on the point source seismic response of a fluid-filled stratified porous medium. The derivation is achieved by a perturbation analysis of the poroelastic wave equations in the plane-wave domain using the Born approximation. This approach yields the Frechet derivatives of the P-SV- and SH-wave responses in terms of the Green's functions of the unperturbed medium. The accuracy and stability of the derived operators are checked by comparing, in the time-distance domain, differential seismograms computed from these analytical expressions with complete solutions obtained by introducing discrete perturbations into the model properties. For vertical and horizontal point forces, it is found that the Frechet derivative approach is remarkably accurate for small and localized perturbations of the medium properties which are consistent with the Born approximation requirements. Furthermore, the first-order formulation appears to be stable at all source-receiver offsets. The porosity, consolidation parameter, solid density, and mineral shear modulus emerge as the most sensitive parameters in forward and inverse modeling problems. Finally, the amplitude-versus-angle response of a thin layer shows strong coupling effects between several model parameters.

Path spectra derived from inversion of source and site spectra for earthquakes in Southern California

NASA Astrophysics Data System (ADS)

Klimasewski, A.; Sahakian, V. J.; Baltay, A.; Boatwright, J.; Fletcher, J. B.; Baker, L. M.

2017-12-01

A large source of epistemic uncertainty in Ground Motion Prediction Equations (GMPEs) is derived from the path term, currently represented as a simple geometric spreading and intrinsic attenuation term. Including additional physical relationships between the path properties and predicted ground motions would produce more accurate and precise, region-specific GMPEs by reclassifying some of the random, aleatory uncertainty as epistemic. This study focuses on regions of Southern California, using data from the Anza network and Southern California Seismic network to create a catalog of events magnitude 2.5 and larger from 1998 to 2016. The catalog encompasses regions of varying geology and therefore varying path and site attenuation. Within this catalog of events, we investigate several collections of event region-to-station pairs, each of which share similar origin locations and stations so that all events have similar paths. Compared with a simple regional GMPE, these paths consistently have high or low residuals. By working with events that have the same path, we can isolate source and site effects, and focus on the remaining residual as path effects. We decompose the recordings into source and site spectra for each unique event and site in our greater Southern California regional database using the inversion method of Andrews (1986). This model represents each natural log record spectra as the sum of its natural log event and site spectra, while constraining each record to a reference site or Brune source spectrum. We estimate a regional, path-specific anelastic attenuation (Q) and site attenuation (t*) from the inversion site spectra and corner frequency from the inversion event spectra. We then compute the residuals between the observed record data, and the inversion model prediction (event*site spectra). This residual is representative of path effects, likely anelastic attenuation along the path that varies from the regional median attenuation. We examine the residuals for our different sets independently to see how path terms differ between event-to-station collections. The path-specific information gained from this can inform development of terms for regional GMPEs, through understanding of these seismological phenomena.

Two-micron Laser Atmospheric Wind Sounder (LAWS) pointing/tracking study

NASA Technical Reports Server (NTRS)

Manlief, Scott

1995-01-01

The objective of the study was to identify and model major sources of short-term pointing jitter for a free-flying, full performance 2 micron LAWS system and evaluate the impact of the short-term jitter on wind-measurement performance. A fast steering mirror controls system was designed for the short-term jitter compensation. The performance analysis showed that the short-term jitter performance of the controls system over the 5.2 msec round-trip time for a realistic spacecraft environment was = 0.3 micro rad, rms, within the specified value of less than 0.5 micro rad, rms, derived in a 2 micron LAWS System Study. Disturbance modes were defined for: (1) the Bearing and Power Transfer Assembly (BAPTA) scan bearing, (2) the spacecraft reaction wheel torques, and (3) the solar array drive torques. The scan bearing disturbance was found to be the greatest contributing noise source to the jitter performance. Disturbances from the fast steering mirror reaction torques and a boom-mounted cross-link antenna clocking were also considered but were judged to be small compared to the three principal disturbance sources above and were not included in the final controls analysis.

Aquifer-nomenclature guidelines

USGS Publications Warehouse

Laney, R.L.; Davidson, C.B.

1986-01-01

Guidelines and recommendations for naming aquifers are presented to assist authors of geohydrological reports in the United States Geological Survey, Water Resources Division. The hierarchy of terms that is used for water- yielding rocks from largest to smallest is aquifer system, aquifer, and zone. If aquifers are named, the names should be derived from lithologic terms, rock-stratigraphic units, or geographic names. The following items are not recommended as sources of aquifer names: time-stratigraphic names, relative position, alphanumeric designations, depositional environment, depth of occurrence, acronyms, and hydrologic conditions. Confining units should not be named unless doing so clearly promotes understanding of a particular aquifer system. Sources of names for confining units are similar to those for aquifer names, i.e. lithologic terms, rock-stratigraphic units or geographic names. Examples of comparison charts and tables that are used to define the geohydrologic framework are included. Aquifers are defined in 11 hypothetical examples that characterize geohydrologic settings throughout the country. (Author 's abstract)

A Fast Method of Deriving the Kirchhoff Formula for Moving Surfaces

NASA Technical Reports Server (NTRS)

Farassat, F.; Posey, Joe W.

2007-01-01

The Kirchhoff formula for a moving surface is very useful in many wave propagation problems, particularly in the prediction of noise from rotating machinery. Several publications in the last two decades have presented derivations of the Kirchhoff formula for moving surfaces in both time and frequency domains. Here we present a method originally developed by Farassat and Myers in time domain that is both simple and direct. It is based on generalized function theory and the useful concept of imbedding the problem in the unbounded three-dimensional space. We derive an inhomogeneous wave equation with the source terms that involve Dirac delta functions with their supports on the moving data surface. This wave equation is then solved using the simple free space Green's function of the wave equation resulting in the Kirchhoff formula. The algebraic manipulations are minimal and simple. We do not need the Green's theorem in four dimensions and there is no ambiguity in the interpretation of any terms in the final formulas. Furthermore, this method also gives the simplest derivation of the classical Kirchhoff formula which has a fairly lengthy derivation in physics and applied mathematics books. The Farassat-Myers method can be used easily in frequency domain.

A wide angle and high Mach number parabolic equation.

PubMed

Lingevitch, Joseph F; Collins, Michael D; Dacol, Dalcio K; Drob, Douglas P; Rogers, Joel C W; Siegmann, William L

2002-02-01

Various parabolic equations for advected acoustic waves have been derived based on the assumptions of small Mach number and narrow propagation angles, which are of limited validity in atmospheric acoustics. A parabolic equation solution that does not require these assumptions is derived in the weak shear limit, which is appropriate for frequencies of about 0.1 Hz and above for atmospheric acoustics. When the variables are scaled appropriately in this limit, terms involving derivatives of the sound speed, density, and wind speed are small but can have significant cumulative effects. To obtain a solution that is valid at large distances from the source, it is necessary to account for linear terms in the first derivatives of these quantities [A. D. Pierce, J. Acoust. Soc. Am. 87, 2292-2299 (1990)]. This approach is used to obtain a scalar wave equation for advected waves. Since this equation contains two depth operators that do not commute with each other, it does not readily factor into outgoing and incoming solutions. An approximate factorization is obtained that is correct to first order in the commutator of the depth operators.

Long-term ferrocyanide application via deicing salts promotes the establishment of Actinomycetales assimilating ferrocyanide-derived carbon in soil.

PubMed

Gschwendtner, Silvia; Mansfeldt, Tim; Kublik, Susanne; Touliari, Evangelia; Buegger, Franz; Schloter, Michael

2016-07-01

Cyanides are highly toxic and produced by various microorganisms as defence strategy or to increase their competitiveness. As degradation is the most efficient way of detoxification, some microbes developed the capability to use cyanides as carbon and nitrogen source. However, it is not clear if this potential also helps to lower cyanide concentrations in roadside soils where deicing salt application leads to significant inputs of ferrocyanide. The question remains if biodegradation in soils can occur without previous photolysis. By conducting a microcosm experiment using soils with/without pre-exposition to road salts spiked with (13) C-labelled ferrocyanide, we were able to confirm biodegradation and in parallel to identify bacteria using ferrocyanide as C source via DNA stable isotope probing (DNA-SIP), TRFLP fingerprinting and pyrosequencing. Bacteria assimilating (13) C were highly similar in the pre-exposed soils, belonging mostly to Actinomycetales (Kineosporia, Mycobacterium, Micromonosporaceae). In the soil without pre-exposition, bacteria belonging to Acidobacteria (Gp3, Gp4, Gp6), Gemmatimonadetes (Gemmatimonas) and Gammaproteobacteria (Thermomonas, Xanthomonadaceae) used ferrocyanide as C source but not the present Actinomycetales. This indicated that (i) various bacteria are able to assimilate ferrocyanide-derived C and (ii) long-term exposition to ferrocyanide applied with deicing salts leads to Actinomycetales outcompeting other microorganisms for the use of ferrocyanide as C source. © 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

Equivalency of Buffalo (Bubalus Bubalis) Embryonic Stem Cells Derived From Fertilized, Parthenogenetic, and Hand-Made Cloned Embryos

PubMed Central

Muzaffar, Musharifa; Selokar, Naresh L.; Singh, Karn P.; Zandi, Mohammad; Singh, Manoj K.; Shah, Riaz A.; Chauhan, Manmohan S.; Singla, Suresh K.; Palta, Prabhat

2012-01-01

Abstract This study was aimed at establishing buffalo embryonic stem cells (ESCs) from in vitro fertilized (IVF), parthenogenetic, and hand-made cloned (HMC) embryos and to check their equivalency in terms of stem cell marker expression, longevity, proliferation, and differentiation pattern. ESCs derived from all three sources were found by immunofluorescence to express the pluripotency markers SSEA-4, TRA-1-60, TRA-1-81, OCT4, and SOX2 and were able to form embryoid bodies containing cells expressing genes specific to endoderm (AFP, HNF4, and GATA4), mesoderm (MSX1, BMP4, and ASA), and ectoderm (cytokeratin 8 and NF68). Reverse transcriptase PCR (RT-PCR) showed cells from all sources to be positive for pluripotency markers OCT4, SOX2, NANOG, STAT3, REX1, FOXD3, NUCLEOSTEMIN, and TELOMERASE. Pluripotency markers OCT4, SOX2, NANOG, and c-MYC were also analyzed by real-time PCR. No significant differences were observed among ESCs from all three sources for all these genes except NANOG, whose expression was higher (p<0.05) in HMC-derived ESCs (6.897±2.3) compared to that in parthenogenesis- and IVF-derived cells (1.603±0.315 and 1±0, respectively). Pluripotent, stable buffalo ESC lines derived from IVF, parthenogenesis, and HMC embryos may be genetically manipulated to provide a powerful tool for studies involving embryonic development, genomic imprinting, gene targeting, cloning, chimera formation, and transgenic animal production. PMID:22582863

Equivalency of buffalo (Bubalus bubalis) embryonic stem cells derived from fertilized, parthenogenetic, and hand-made cloned embryos.

PubMed

Muzaffar, Musharifa; Selokar, Naresh L; Singh, Karn P; Zandi, Mohammad; Singh, Manoj K; Shah, Riaz A; Chauhan, Manmohan S; Singla, Suresh K; Palta, Prabhat; Manik, Radheysham

2012-06-01

This study was aimed at establishing buffalo embryonic stem cells (ESCs) from in vitro fertilized (IVF), parthenogenetic, and hand-made cloned (HMC) embryos and to check their equivalency in terms of stem cell marker expression, longevity, proliferation, and differentiation pattern. ESCs derived from all three sources were found by immunofluorescence to express the pluripotency markers SSEA-4, TRA-1-60, TRA-1-81, OCT4, and SOX2 and were able to form embryoid bodies containing cells expressing genes specific to endoderm (AFP, HNF4, and GATA4), mesoderm (MSX1, BMP4, and ASA), and ectoderm (cytokeratin 8 and NF68). Reverse transcriptase PCR (RT-PCR) showed cells from all sources to be positive for pluripotency markers OCT4, SOX2, NANOG, STAT3, REX1, FOXD3, NUCLEOSTEMIN, and TELOMERASE. Pluripotency markers OCT4, SOX2, NANOG, and c-MYC were also analyzed by real-time PCR. No significant differences were observed among ESCs from all three sources for all these genes except NANOG, whose expression was higher (p<0.05) in HMC-derived ESCs (6.897±2.3) compared to that in parthenogenesis- and IVF-derived cells (1.603±0.315 and 1±0, respectively). Pluripotent, stable buffalo ESC lines derived from IVF, parthenogenesis, and HMC embryos may be genetically manipulated to provide a powerful tool for studies involving embryonic development, genomic imprinting, gene targeting, cloning, chimera formation, and transgenic animal production.

Glucose responsive insulin production from human embryonic germ (EG) cell derivatives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, Gregory O.; Yochem, Robert L.; Axelman, Joyce

2007-05-11

Type 1 diabetes mellitus subjects millions to a daily burden of disease management, life threatening hypoglycemia and long-term complications such as retinopathy, nephropathy, heart disease, and stroke. Cell transplantation therapies providing a glucose-regulated supply of insulin have been implemented clinically, but are limited by safety, efficacy and supply considerations. Stem cells promise a plentiful and flexible source of cells for transplantation therapies. Here, we show that cells derived from human embryonic germ (EG) cells express markers of definitive endoderm, pancreatic and {beta}-cell development, glucose sensing, and production of mature insulin. These cells integrate functions necessary for glucose responsive regulation ofmore » preproinsulin mRNA and expression of insulin C-peptide in vitro. Following transplantation into mice, cells become insulin and C-peptide immunoreactive and produce plasma C-peptide in response to glucose. These findings suggest that EG cell derivatives may eventually serve as a source of insulin producing cells for the treatment of diabetes.« less

Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation

PubMed Central

Shono, Akemi; Yoshida, Makiko; Yamana, Keiji; Thwin, Khin Kyae Mon; Kuroda, Jumpei; Kurokawa, Daisuke; Koda, Tsubasa; Nishida, Kosuke; Ikuta, Toshihiko; Mizobuchi, Masami; Taniguchi-Ikeda, Mariko

2017-01-01

Mesenchymal stem cells (MSCs) are a heterogeneous cell population that is isolated initially from the bone marrow (BM) and subsequently almost all tissues including umbilical cord (UC). UC-derived MSCs (UC-MSCs) have attracted an increasing attention as a source for cell therapy against various degenerative diseases due to their vigorous proliferation and differentiation. Although the cell proliferation and differentiation of BM-derived MSCs is known to decline with age, the functional difference between preterm and term UC-MSCs is poorly characterized. In the present study, we isolated UC-MSCs from 23 infants delivered at 22–40 weeks of gestation and analyzed their gene expression and cell proliferation. Microarray analysis revealed that global gene expression in preterm UC-MSCs was distinct from term UC-MSCs. WNT signaling impacts on a variety of tissue stem cell proliferation and differentiation, and its pathway genes were enriched in differentially expressed genes between preterm and term UC-MSCs. Cell proliferation of preterm UC-MSCs was significantly enhanced compared to term UC-MSCs and counteracted by WNT signaling inhibitor XAV939. Furthermore, WNT2B expression in UC-MSCs showed a significant negative correlation with gestational age (GA). These results suggest that WNT signaling is involved in the regulation of GA-dependent UC-MSC proliferation. PMID:29138639

The Role of Near-Earth Asteroids in Long-Term Platinum Supply

NASA Astrophysics Data System (ADS)

Blair, B. R.

2000-01-01

High-grade platinum-group metal concentrations have been identified in an abundant class of near-Earth asteroids known as LL Chondrites. The potential existence of a high-value asteroid-derived mineral product is examined from an economic perspective to assess the possible impacts on long-term precious metal supply. It is hypothesized that extraterrestrial sources of platinum group metals will become available in the global marketplace in a 20-year time frame, based on current trends of growth in technology and increasing levels of human activities in near-Earth space. Current and projected trends in platinum supply and demand are cited from the relevant literature to provide an economic context and provide an example for evaluating the economic potential of future asteroid-derived precious and strategic metals.

Exosomes Derived From Pancreatic Stellate Cells: MicroRNA Signature and Effects on Pancreatic Cancer Cells.

PubMed

Takikawa, Tetsuya; Masamune, Atsushi; Yoshida, Naoki; Hamada, Shin; Kogure, Takayuki; Shimosegawa, Tooru

2017-01-01

Pancreatic stellate cells (PSCs) interact with pancreatic cancer cells in the tumor microenvironment. Cell constituents including microRNAs may be exported from cells within membranous nanovesicles termed exosomes. Exosomes might play a pivotal role in intercellular communication. This study aimed to clarify the microRNA signature of PSC-derived exosomes and their effects on pancreatic cancer cells. Exosomes were prepared from the conditioned medium of immortalized human PSCs. MicroRNAs were prepared from the exosomes and their source PSCs, and the microRNA expression profiles were compared by microarray. The effects of PSC-derived exosomes on proliferation, migration, and the mRNA expression profiles were examined in pancreatic cancer cells. Pancreatic stellate cell-derived exosomes contained a variety of microRNAs including miR-21-5p. Several microRNAs such as miR-451a were enriched in exosomes compared to their source PSCs. Pancreatic stellate cell-derived exosomes stimulated the proliferation, migration and expression of mRNAs for chemokine (C - X - C motif) ligands 1 and 2 in pancreatic cancer cells. The stimulation of proliferation, migration, and chemokine gene expression by the conditioned medium of PSCs was suppressed by GW4869, an exosome inhibitor. We clarified the microRNA expression profile in PSC-derived exosomes. Pancreatic stellate cell-derived exosomes might play a role in the interactions between PSCs and pancreatic cancer cells.

Seismic hazard assessment over time: Modelling earthquakes in Taiwan

NASA Astrophysics Data System (ADS)

Chan, Chung-Han; Wang, Yu; Wang, Yu-Ju; Lee, Ya-Ting

2017-04-01

To assess the seismic hazard with temporal change in Taiwan, we develop a new approach, combining both the Brownian Passage Time (BPT) model and the Coulomb stress change, and implement the seismogenic source parameters by the Taiwan Earthquake Model (TEM). The BPT model was adopted to describe the rupture recurrence intervals of the specific fault sources, together with the time elapsed since the last fault-rupture to derive their long-term rupture probability. We also evaluate the short-term seismicity rate change based on the static Coulomb stress interaction between seismogenic sources. By considering above time-dependent factors, our new combined model suggests an increased long-term seismic hazard in the vicinity of active faults along the western Coastal Plain and the Longitudinal Valley, where active faults have short recurrence intervals and long elapsed time since their last ruptures, and/or short-term elevated hazard levels right after the occurrence of large earthquakes due to the stress triggering effect. The stress enhanced by the February 6th, 2016, Meinong ML 6.6 earthquake also significantly increased rupture probabilities of several neighbouring seismogenic sources in Southwestern Taiwan and raised hazard level in the near future. Our approach draws on the advantage of incorporating long- and short-term models, to provide time-dependent earthquake probability constraints. Our time-dependent model considers more detailed information than any other published models. It thus offers decision-makers and public officials an adequate basis for rapid evaluations of and response to future emergency scenarios such as victim relocation and sheltering.

Forcing scheme analysis for the axisymmetric lattice Boltzmann method under incompressible limit.

PubMed

Zhang, Liangqi; Yang, Shiliang; Zeng, Zhong; Chen, Jie; Yin, Linmao; Chew, Jia Wei

2017-04-01

Because the standard lattice Boltzmann (LB) method is proposed for Cartesian Navier-Stokes (NS) equations, additional source terms are necessary in the axisymmetric LB method for representing the axisymmetric effects. Therefore, the accuracy and applicability of the axisymmetric LB models depend on the forcing schemes adopted for discretization of the source terms. In this study, three forcing schemes, namely, the trapezium rule based scheme, the direct forcing scheme, and the semi-implicit centered scheme, are analyzed theoretically by investigating their derived macroscopic equations in the diffusive scale. Particularly, the finite difference interpretation of the standard LB method is extended to the LB equations with source terms, and then the accuracy of different forcing schemes is evaluated for the axisymmetric LB method. Theoretical analysis indicates that the discrete lattice effects arising from the direct forcing scheme are part of the truncation error terms and thus would not affect the overall accuracy of the standard LB method with general force term (i.e., only the source terms in the momentum equation are considered), but lead to incorrect macroscopic equations for the axisymmetric LB models. On the other hand, the trapezium rule based scheme and the semi-implicit centered scheme both have the advantage of avoiding the discrete lattice effects and recovering the correct macroscopic equations. Numerical tests applied for validating the theoretical analysis show that both the numerical stability and the accuracy of the axisymmetric LB simulations are affected by the direct forcing scheme, which indicate that forcing schemes free of the discrete lattice effects are necessary for the axisymmetric LB method.

Many Roads Lead to Recognition: Electrophysiological Correlates of Familiarity Derived from Short-Term Masked Repetition Priming

ERIC Educational Resources Information Center

Lucas, Heather D.; Taylor, Jason R.; Henson, Richard N.; Paller, Ken A.

2012-01-01

The neural mechanisms that underlie familiarity memory have been extensively investigated, but a consensus understanding remains elusive. Behavioral evidence suggests that familiarity sometimes shares sources with instances of implicit memory known as priming, in that the same increases in processing fluency that give rise to priming can engender…

Telling the story of tree species’ range shifts in a complex landscape

Treesearch

Sharon M. Stanton; Vicente J. Monleon; Heather E. Lintz; Joel Thompson

2015-01-01

The Forest Inventory and Analysis Program is the unrivaled source for long-term, spatially balanced, publicly available data. FIA will continue to be providers of data, but the program is growing and adapting, including a shift in how we communicate information and knowledge derived from those data. Online applications, interactive mapping, and infographics provide...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sugama, H.; Nunami, M.; Department of Fusion Science, SOKENDAI

Effects of collisions on conservation laws for toroidal plasmas are investigated based on the gyrokinetic field theory. Associating the collisional system with a corresponding collisionless system at a given time such that the two systems have the same distribution functions and electromagnetic fields instantaneously, it is shown how the collisionless conservation laws derived from Noether's theorem are modified by the collision term. Effects of the external source term added into the gyrokinetic equation can be formulated similarly with the collisional effects. Particle, energy, and toroidal momentum balance equations including collisional and turbulent transport fluxes are systematically derived using a novelmore » gyrokinetic collision operator, by which the collisional change rates of energy and canonical toroidal angular momentum per unit volume in the gyrocenter space can be given in the conservative forms. The ensemble-averaged transport equations of particles, energy, and toroidal momentum given in the present work are shown to include classical, neoclassical, and turbulent transport fluxes which agree with those derived from conventional recursive formulations.« less

Prescribers prefer people: The sources of information used by doctors for prescribing suggest that the medium is more important than the message

PubMed Central

McGettigan, P; Golden, J; Fryer, J; Chan, R; Feely, J

2001-01-01

Aims The sources of prescribing information are legion but there is little knowledge about which are actually used in practice by doctors when prescribing. The aims of this study were to determine the sources of prescribing information considered important by doctors, establish which were used in practice, and investigate if hospital and primary care physicians differed in their use of the sources. Methods Two hundred general practitioners (GPs) and 230 hospital doctors were asked to rate information sources in terms of their importance for prescribing ‘old’ and ‘new’ drugs, and then to name the source from which information about the last new drug prescribed was actually derived. Results Among 108 GPs, the Drugs and Therapeutics Bulletin and medical journal articles were most frequently rated as important for information on both old and new drugs while pharmaceutical representatives and hospital/consultant recommendations were more important for information on new drugs, as opposed to old. In practice, information on the last new drug prescribed was derived from pharmaceutical representatives in 42% of cases and hospital/consultant recommendations in 36%, with other sources used infrequently. Among 118 hospital doctors, the British National Formulary (BNF) and senior colleagues were of greatest theoretical importance. In practice, information on the last new drug prescribed was derived from a broad range of sources: colleagues, 29%; pharmaceutical representatives, 18%; hospital clinical meetings, 15%; journal articles, 13%; lectures, 10%. GPs and hospital doctors differed significantly in their use of pharmaceutical representatives (42% vs 18%) and colleagues (7% vs 29%) as sources of prescribing information (P < 0.0001 for both). Conclusions The sources most frequently rated important in theory were not those most used in practice, especially among GPs. Both groups under-estimated the importance of pharmaceutical representatives. Most importantly, the sources of greatest practical importance were those involving the transfer of information through the medium of personal contact. PMID:11259994

Evaluation of actuator energy storage and power sources for spacecraft applications

NASA Technical Reports Server (NTRS)

Simon, William E.; Young, Fred M.

1993-01-01

The objective of this evaluation is to determine an optimum energy storage/power source combination for electrical actuation systems for existing (Solid Rocket Booster (SRB), Shuttle) and future (Advanced Launch System (ALS), Shuttle Derivative) vehicles. Characteristic of these applications is the requirement for high power pulses (50-200 kW) for short times (milliseconds to seconds), coupled with longer-term base or 'housekeeping' requirements (5-16 kW). Specific study parameters (e.g., weight, volume, etc.) as stated in the proposal and specified in the Statement of Work (SOW) are included.

TE/TM decomposition of electromagnetic sources

NASA Technical Reports Server (NTRS)

Lindell, Ismo V.

1988-01-01

Three methods are given by which bounded EM sources can be decomposed into two parts radiating transverse electric (TE) and transverse magnetic (TM) fields with respect to a given constant direction in space. The theory applies source equivalence and nonradiating source concepts, which lead to decomposition methods based on a recursive formula or two differential equations for the determination of the TE and TM components of the original source. Decompositions for a dipole in terms of point, line, and plane sources are studied in detail. The planar decomposition is seen to match to an earlier result given by Clemmow (1963). As an application of the point decomposition method, it is demonstrated that the general exact image expression for the Sommerfeld half-space problem, previously derived through heuristic reasoning, can be more straightforwardly obtained through the present decomposition method.

The Life of Meaning: A Model of the Positive Contributions to Well-Being from Veterinary Work.

PubMed

Cake, Martin A; Bell, Melinda A; Bickley, Naomi; Bartram, David J

2015-01-01

We present a veterinary model of work-derived well-being, and argue that educators should not only present a (potentially self-fulfilling) stress management model of future wellness, but also balance this with a positive psychology-based approach depicting a veterinary career as a richly generative source of satisfaction and fulfillment. A review of known sources of satisfaction for veterinarians finds them to be based mostly in meaningful purpose, relationships, and personal growth. This positions veterinary well-being within the tradition of eudaimonia, an ancient concept of achieving one's best possible self, and a term increasingly employed to describe well-being derived from living a life that is engaging, meaningful, and deeply fulfilling. The theory of eudaimonia for workplace well-being should inform development of personal resources that foster resilience in undergraduate and graduate veterinarians.

Trace-element and Nd-isotope systematics in detrital apatite of the Po river catchment: Implications for provenance discrimination and the lag-time approach to detrital thermochronology

NASA Astrophysics Data System (ADS)

Malusà, Marco G.; Wang, Jiangang; Garzanti, Eduardo; Liu, Zhi-Chao; Villa, Igor M.; Wittmann, Hella

2017-10-01

Detrital thermochronology is often employed to assess the evolutionary stage of an entire orogenic belt using the lag-time approach, i.e., the difference between the cooling and depositional ages of detrital mineral grains preserved in a stratigraphic succession. The impact of different eroding sources to the final sediment sink is controlled by several factors, including the short-term erosion rate and the mineral fertility of eroded bedrock. Here, we use apatite fertility data and cosmogenic-derived erosion rates in the Po river catchment (Alps-Apennines) to calculate the expected percentage of apatite grains supplied to the modern Po delta from the major Alpine and Apenninic eroding sources. We test these predictions by using a cutting-edge dataset of trace-element and Nd-isotope signatures on 871 apatite grains from 14 modern sand samples, and we use apatite fission-track data to validate our geochemical approach to provenance discrimination. We found that apatite grains shed from different sources are geochemically distinct. Apatites from the Lepontine dome in the Central Alps show relative HREE enrichment, lower concentrations in Ce and U, and higher 147Sm/144Nd ratios compared to apatites derived from the External Massifs. Derived provenance budgets point to a dominant apatite contribution to the Po delta from the high-fertility Lepontine dome, consistent with the range independently predicted from cosmonuclide and mineral-fertility data. Our results demonstrate that the single-mineral record in the final sediment sink can be largely determined by high-fertility source rocks exposed in rapidly eroding areas within the drainage. This implies that the detrital thermochronology record may reflect processes affecting relatively small parts of the orogenic system under consideration. A reliable approach to lag-time analysis would thus benefit from an independent provenance discrimination of dated mineral grains, which may allow to proficiently reconsider many previous interpretations of detrital thermochronology datasets in terms of orogenic-wide steady state.

The 'CommTech' Methodology: A Demand-Driven Approach to Efficient, Productive and Measurable Technology Transfer

NASA Technical Reports Server (NTRS)

Horsham, Gray A. P.

1998-01-01

Market research sources were used to initially gather primary technological problems and needs data from non-aerospace companies in targeted industry sectors. The company-supplied information served as input data to activate or start-up an internal, phased match-making process. This process was based on technical-level relationship exploration followed by business-level agreement negotiations, and culminated with project management and execution. Space Act Agreements represented near-term outputs. Company product or process commercialization derived from Lewis support and measurable economic effects represented far-term outputs.

Algorithms for System Identification and Source Location.

NASA Astrophysics Data System (ADS)

Nehorai, Arye

This thesis deals with several topics in least squares estimation and applications to source location. It begins with a derivation of a mapping between Wiener theory and Kalman filtering for nonstationary autoregressive moving average (ARMO) processes. Applying time domain analysis, connections are found between time-varying state space realizations and input-output impulse response by matrix fraction description (MFD). Using these connections, the whitening filters are derived by the two approaches, and the Kalman gain is expressed in terms of Wiener theory. Next, fast estimation algorithms are derived in a unified way as special cases of the Conjugate Direction Method. The fast algorithms included are the block Levinson, fast recursive least squares, ladder (or lattice) and fast Cholesky algorithms. The results give a novel derivation and interpretation for all these methods, which are efficient alternatives to available recursive system identification algorithms. Multivariable identification algorithms are usually designed only for left MFD models. In this work, recursive multivariable identification algorithms are derived for right MFD models with diagonal denominator matrices. The algorithms are of prediction error and model reference type. Convergence analysis results obtained by the Ordinary Differential Equation (ODE) method are presented along with simulations. Sources of energy can be located by estimating time differences of arrival (TDOA's) of waves between the receivers. A new method for TDOA estimation is proposed for multiple unknown ARMA sources and additive correlated receiver noise. The method is based on a formula that uses only the receiver cross-spectra and the source poles. Two algorithms are suggested that allow tradeoffs between computational complexity and accuracy. A new time delay model is derived and used to show the applicability of the methods for non -integer TDOA's. Results from simulations illustrate the performance of the algorithms. The last chapter analyzes the response of exact least squares predictors for enhancement of sinusoids with additive colored noise. Using the matrix inversion lemma and the Christoffel-Darboux formula, the frequency response and amplitude gain of the sinusoids are expressed as functions of the signal and noise characteristics. The results generalize the available white noise case.

Isotropic source terms of San Jacinto fault zone earthquakes based on waveform inversions with a generalized CAP method

NASA Astrophysics Data System (ADS)

Ross, Z. E.; Ben-Zion, Y.; Zhu, L.

2015-02-01

We analyse source tensor properties of seven Mw > 4.2 earthquakes in the complex trifurcation area of the San Jacinto Fault Zone, CA, with a focus on isotropic radiation that may be produced by rock damage in the source volumes. The earthquake mechanisms are derived with generalized `Cut and Paste' (gCAP) inversions of three-component waveforms typically recorded by >70 stations at regional distances. The gCAP method includes parameters ζ and χ representing, respectively, the relative strength of the isotropic and CLVD source terms. The possible errors in the isotropic and CLVD components due to station variability is quantified with bootstrap resampling for each event. The results indicate statistically significant explosive isotropic components for at least six of the events, corresponding to ˜0.4-8 per cent of the total potency/moment of the sources. In contrast, the CLVD components for most events are not found to be statistically significant. Trade-off and correlation between the isotropic and CLVD components are studied using synthetic tests with realistic station configurations. The associated uncertainties are found to be generally smaller than the observed isotropic components. Two different tests with velocity model perturbation are conducted to quantify the uncertainty due to inaccuracies in the Green's functions. Applications of the Mann-Whitney U test indicate statistically significant explosive isotropic terms for most events consistent with brittle damage production at the source.

Fermi Large Area Telescope Second Source Catalog

NASA Technical Reports Server (NTRS)

Nolan, P. L.; Abdo, A. A.; Ackermann, M.; Ajello, M; Allafort, A.; Antolini, E; Bonnell, J.; Cannon, A.; Celik O.; Corbet, R.;

Edge detection of magnetic anomalies using analytic signal of tilt angle (ASTA)

NASA Astrophysics Data System (ADS)

Alamdar, K.; Ansari, A. H.; Ghorbani, A.

2009-04-01

Magnetic is a commonly used geophysical technique to identify and image potential subsurface targets. Interpretation of magnetic anomalies is a complex process due to the superposition of multiple magnetic sources, presence of geologic and cultural noise and acquisition and positioning error. Both the vertical and horizontal derivatives of potential field data are useful; horizontal derivative, enhance edges whereas vertical derivative narrow the width of anomaly and so locate source bodies more accurately. We can combine vertical and horizontal derivative of magnetic field to achieve analytic signal which is independent to body magnetization direction and maximum value of this lies over edges of body directly. Tilt angle filter is phased-base filter and is defined as angle between vertical derivative and total horizontal derivative. Tilt angle value differ from +90 degree to -90 degree and its zero value lies over body edge. One of disadvantage of this filter is when encountering with deep sources the detected edge is blurred. For overcome this problem many authors introduced new filters such as total horizontal derivative of tilt angle or vertical derivative of tilt angle which Because of using high-order derivative in these filters results may be too noisy. If we combine analytic signal and tilt angle, a new filter termed (ASTA) is produced which its maximum value lies directly over body edge and is easer than tilt angle to delineate body edge and no complicity of tilt angle. In this work new filter has been demonstrated on magnetic data from an area in Sar- Cheshme region in Iran. This area is located in 55 degree longitude and 32 degree latitude and is a copper potential region. The main formation in this area is Andesith and Trachyandezite. Magnetic surveying was employed to separate the boundaries of Andezite and Trachyandezite from adjacent area. In this regard a variety of filters such as analytic signal, tilt angle and ASTA filter have been applied which new ASTA filter determined Andezite boundaries from surrounded more accurately than other filters. Keywords: Horizontal derivative, Vertical derivative, Tilt angle, Analytic signal, ASTA, Sar-Cheshme.

The importance of quadrupole sources in prediction of transonic tip speed propeller noise

NASA Technical Reports Server (NTRS)

Hanson, D. B.; Fink, M. R.

1978-01-01

A theoretical analysis is presented for the harmonic noise of high speed, open rotors. Far field acoustic radiation equations based on the Ffowcs-Williams/Hawkings theory are derived for a static rotor with thin blades and zero lift. Near the plane of rotation, the dominant sources are the volume displacement and the rho U(2) quadrupole, where u is the disturbance velocity component in the direction blade motion. These sources are compared in both the time domain and the frequency domain using two dimensional airfoil theories valid in the subsonic, transonic, and supersonic speed ranges. For nonlifting parabolic arc blades, the two sources are equally important at speeds between the section critical Mach number and a Mach number of one. However, for moderately subsonic or fully supersonic flow over thin blade sections, the quadrupole term is negligible. It is concluded for thin blades that significant quadrupole noise radiation is strictly a transonic phenomenon and that it can be suppressed with blade sweep. Noise calculations are presented for two rotors, one simulating a helicopter main rotor and the other a model propeller. For the latter, agreement with test data was substantially improved by including the quadrupole source term.

Universally coupled massive gravity, III: dRGT–Maheshwari pure spin-2, Ogievetsky–Polubarinov and arbitrary mass terms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pitts, J. Brian, E-mail: jbp25@cam.ac.uk

2016-02-15

Einstein’s equations were derived for a free massless spin-2 field using universal coupling in the 1950–1970s by various authors; total stress–energy including gravity’s served as a source for linear free field equations. A massive variant was likewise derived in the late 1960s by Freund, Maheshwari and Schonberg, and thought to be unique. How broad is universal coupling? In the last decade four 1-parameter families of massive spin-2 theories (contravariant, covariant, tetrad, and cotetrad of almost any density weights) have been derived using universal coupling. The (co)tetrad derivations included 2 of the 3 pure spin-2 theories due to de Rham, Gabadadze,more » and Tolley; those two theories first appeared in the 2-parameter Ogievetsky–Polubarinov family (1965), which developed the symmetric square root of the metric as a nonlinear group realization. One of the two theories was identified as pure spin-2 by Maheshwari in 1971–1972, thus evading the Boulware–Deser–Tyutin–Fradkin ghost by the time it was announced. Unlike the previous 4 families, this paper permits nonlinear field redefinitions to build the effective metric. By not insisting in advance on knowing the observable significance of the graviton potential to all orders, one finds that an arbitrary graviton mass term can be derived using universal coupling. The arbitrariness of a universally coupled mass/self-interaction term contrasts sharply with the uniqueness of the Einstein kinetic term. One might have hoped to use universal coupling as a tie-breaking criterion for choosing among theories that are equally satisfactory on more crucial grounds (such as lacking ghosts and having a smooth massless limit). But the ubiquity of universal coupling implies that the criterion does not favor any particular theories among those with the Einstein kinetic term.« less

Comprehensive screening for immunodeficiency-associated vaccine-derived poliovirus: an essential oral poliovirus vaccine cessation risk management strategy.

PubMed

Duintjer Tebbens, R J; Thompson, K M

2017-01-01

If the world can successfully control all outbreaks of circulating vaccine-derived poliovirus that may occur soon after global oral poliovirus vaccine (OPV) cessation, then immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) from rare and mostly asymptomatic long-term excretors (defined as ⩾6 months of excretion) will become the main source of potential poliovirus outbreaks for as long as iVDPV excretion continues. Using existing models of global iVDPV prevalence and global long-term poliovirus risk management, we explore the implications of uncertainties related to iVDPV risks, including the ability to identify asymptomatic iVDPV excretors to treat with polio antiviral drugs (PAVDs) and the transmissibility of iVDPVs. The expected benefits of expanded screening to identify and treat long-term iVDPV excretors with PAVDs range from US$0.7 to 1.5 billion with the identification of 25-90% of asymptomatic long-term iVDPV excretors, respectively. However, these estimates depend strongly on assumptions about the transmissibility of iVDPVs and model inputs affecting the global iVDPV prevalence. For example, the expected benefits may decrease to as low as US$260 million with the identification of 90% of asymptomatic iVDPV excretors if iVDPVs behave and transmit like partially reverted viruses instead of fully reverted viruses. Comprehensive screening for iVDPVs will reduce uncertainties and maximize the expected benefits of PAVD use.

(U) An Analytic Examination of Piezoelectric Ejecta Mass Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tregillis, Ian Lee

2017-02-02

Ongoing efforts to validate a Richtmyer-Meshkov instability (RMI) based ejecta source model [1, 2, 3] in LANL ASC codes use ejecta areal masses derived from piezoelectric sensor data [4, 5, 6]. However, the standard technique for inferring masses from sensor voltages implicitly assumes instantaneous ejecta creation [7], which is not a feature of the RMI source model. To investigate the impact of this discrepancy, we define separate “areal mass functions” (AMFs) at the source and sensor in terms of typically unknown distribution functions for the ejecta particles, and derive an analytic relationship between them. Then, for the case of single-shockmore » ejection into vacuum, we use the AMFs to compare the analytic (or “true”) accumulated mass at the sensor with the value that would be inferred from piezoelectric voltage measurements. We confirm the inferred mass is correct when creation is instantaneous, and furthermore prove that when creation is not instantaneous, the inferred values will always overestimate the true mass. Finally, we derive an upper bound for the error imposed on a perfect system by the assumption of instantaneous ejecta creation. When applied to shots in the published literature, this bound is frequently less than several percent. Errors exceeding 15% may require velocities or timescales at odds with experimental observations.« less

Recording and quantification of ultrasonic echolocation clicks from free-ranging toothed whales

NASA Astrophysics Data System (ADS)

Madsen, P. T.; Wahlberg, M.

2007-08-01

Toothed whales produce short, ultrasonic clicks of high directionality and source level to probe their environment acoustically. This process, termed echolocation, is to a large part governed by the properties of the emitted clicks. Therefore derivation of click source parameters from free-ranging animals is of increasing importance to understand both how toothed whales use echolocation in the wild and how they may be monitored acoustically. This paper addresses how source parameters can be derived from free-ranging toothed whales in the wild using calibrated multi-hydrophone arrays and digital recorders. We outline the properties required of hydrophones, amplifiers and analog to digital converters, and discuss the problems of recording echolocation clicks on the axis of a directional sound beam. For accurate localization the hydrophone array apertures must be adapted and scaled to the behavior of, and the range to, the clicking animal, and precise information on hydrophone locations is critical. We provide examples of localization routines and outline sources of error that lead to uncertainties in localizing clicking animals in time and space. Furthermore we explore approaches to time series analysis of discrete versions of toothed whale clicks that are meaningful in a biosonar context.

A moving medium formulation for prediction of propeller noise at incidence

NASA Astrophysics Data System (ADS)

Ghorbaniasl, Ghader; Lacor, Chris

2012-01-01

This paper presents a time domain formulation for the sound field radiated by moving bodies in a uniform steady flow with arbitrary orientation. The aim is to provide a formulation for prediction of noise from body so that effects of crossflow on a propeller can be modeled in the time domain. An established theory of noise generation by a moving source is combined with the moving medium Green's function for derivation of the formulation. A formula with Doppler factor is developed because it is more easily interpreted and is more helpful in examining the physic of systems. Based on the technique presented, the source of asymmetry of the sound field can be explained in terms of physics of a moving source. It is shown that the derived formulation can be interpreted as an extension of formulation 1 and 1A of Farassat based on the Ffowcs Williams and Hawkings (FW-H) equation for moving medium problems. Computational results for a stationary monopole and dipole point source in moving medium, a rotating point force in crossflow, a model of helicopter blade at incidence and a propeller case with subsonic tips at incidence verify the formulation.

Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS).

PubMed

Li, Ji; Larregieu, Caroline A; Benet, Leslie Z

2016-12-01

Natural products (NPs) are compounds that are derived from natural sources such as plants, animals, and micro-organisms. Therapeutics has benefited from numerous drug classes derived from natural product sources. The Biopharmaceutics Drug Disposition Classification System (BDDCS) was proposed to serve as a basis for predicting the importance of transporters and enzymes in determining drug bioavailability and disposition. It categorizes drugs into one of four biopharmaceutical classes according to their water solubility and extent of metabolism. The present paper reviews 109 drugs from natural product sources: 29% belong to class 1 (high solubility, extensive metabolism), 22% to class 2 (low solubility, extensive metabolism), 40% to class 3 (high solubility, poor metabolism), and 9% to class 4 (low solubility, poor metabolism). Herein we evaluated the characteristics of NPs in terms of BDDCS class for all 109 drugs as wells as for subsets of NPs drugs derived from plant sources as antibiotics. In the 109 NPs drugs, we compiled 32 drugs from plants, 50% (16) of total in class 1, 22% (7) in class 2 and 28% (9) in class 3, none found in class 4; Meantime, the antibiotics were found 5 (16%) in class 2, 22 (71%) in class 3, and 4 (13%) in class 4; no drug was found in class 1. Based on this classification, we anticipate BDDCS to serve as a useful adjunct in evaluating the potential characteristics of new natural products. Copyright © 2016 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation.

PubMed

Dmochowski, Jacek P; Koessler, Laurent; Norcia, Anthony M; Bikson, Marom; Parra, Lucas C

2017-08-15

To demonstrate causal relationships between brain and behavior, investigators would like to guide brain stimulation using measurements of neural activity. Particularly promising in this context are electroencephalography (EEG) and transcranial electrical stimulation (TES), as they are linked by a reciprocity principle which, despite being known for decades, has not led to a formalism for relating EEG recordings to optimal stimulation parameters. Here we derive a closed-form expression for the TES configuration that optimally stimulates (i.e., targets) the sources of recorded EEG, without making assumptions about source location or distribution. We also derive a duality between TES targeting and EEG source localization, and demonstrate that in cases where source localization fails, so does the proposed targeting. Numerical simulations with multiple head models confirm these theoretical predictions and quantify the achieved stimulation in terms of focality and intensity. We show that constraining the stimulation currents automatically selects optimal montages that involve only a few (4-7) electrodes, with only incremental loss in performance when targeting focal activations. The proposed technique allows brain scientists and clinicians to rationally target the sources of observed EEG and thus overcomes a major obstacle to the realization of individualized or closed-loop brain stimulation. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation

PubMed Central

Dmochowski, Jacek P.; Koessler, Laurent; Norcia, Anthony M.; Bikson, Marom; Parra, Lucas C.

2018-01-01

To demonstrate causal relationships between brain and behavior, investigators would like to guide brain stimulation using measurements of neural activity. Particularly promising in this context are electroencephalography (EEG) and transcranial electrical stimulation (TES), as they are linked by a reciprocity principle which, despite being known for decades, has not led to a formalism for relating EEG recordings to optimal stimulation parameters. Here we derive a closed-form expression for the TES configuration that optimally stimulates (i.e., targets) the sources of recorded EEG, without making assumptions about source location or distribution. We also derive a duality between TES targeting and EEG source localization, and demonstrate that in cases where source localization fails, so does the proposed targeting. Numerical simulations with multiple head models confirm these theoretical predictions and quantify the achieved stimulation in terms of focality and intensity. We show that constraining the stimulation currents automatically selects optimal montages that involve only a few (4–7) electrodes, with only incremental loss in performance when targeting focal activations. The proposed technique allows brain scientists and clinicians to rationally target the sources of observed EEG and thus overcomes a major obstacle to the realization of individualized or closed-loop brain stimulation. PMID:28578130

A simple mass-conserved level set method for simulation of multiphase flows

NASA Astrophysics Data System (ADS)

Yuan, H.-Z.; Shu, C.; Wang, Y.; Shu, S.

2018-04-01

In this paper, a modified level set method is proposed for simulation of multiphase flows with large density ratio and high Reynolds number. The present method simply introduces a source or sink term into the level set equation to compensate the mass loss or offset the mass increase. The source or sink term is derived analytically by applying the mass conservation principle with the level set equation and the continuity equation of flow field. Since only a source term is introduced, the application of the present method is as simple as the original level set method, but it can guarantee the overall mass conservation. To validate the present method, the vortex flow problem is first considered. The simulation results are compared with those from the original level set method, which demonstrates that the modified level set method has the capability of accurately capturing the interface and keeping the mass conservation. Then, the proposed method is further validated by simulating the Laplace law, the merging of two bubbles, a bubble rising with high density ratio, and Rayleigh-Taylor instability with high Reynolds number. Numerical results show that the mass is a well-conserved by the present method.

Two dimensional radial gas flows in atmospheric pressure plasma-enhanced chemical vapor deposition

NASA Astrophysics Data System (ADS)

Kim, Gwihyun; Park, Seran; Shin, Hyunsu; Song, Seungho; Oh, Hoon-Jung; Ko, Dae Hong; Choi, Jung-Il; Baik, Seung Jae

2017-12-01

Atmospheric pressure (AP) operation of plasma-enhanced chemical vapor deposition (PECVD) is one of promising concepts for high quality and low cost processing. Atmospheric plasma discharge requires narrow gap configuration, which causes an inherent feature of AP PECVD. Two dimensional radial gas flows in AP PECVD induces radial variation of mass-transport and that of substrate temperature. The opposite trend of these variations would be the key consideration in the development of uniform deposition process. Another inherent feature of AP PECVD is confined plasma discharge, from which volume power density concept is derived as a key parameter for the control of deposition rate. We investigated deposition rate as a function of volume power density, gas flux, source gas partial pressure, hydrogen partial pressure, plasma source frequency, and substrate temperature; and derived a design guideline of deposition tool and process development in terms of deposition rate and uniformity.

Potential antitumor therapeutic strategies of human amniotic membrane and amniotic fluid-derived stem cells.

PubMed

Kang, N-H; Hwang, K-A; Kim, S U; Kim, Y-B; Hyun, S-H; Jeung, E-B; Choi, K-C

2012-08-01

As stem cells are capable of self-renewal and can generate differentiated progenies for organ development, they are considered as potential source for regenerative medicine and tissue replacement after injury or disease. Along with this capacity, stem cells have the therapeutic potential for treating human diseases including cancers. According to the origins, stem cells are broadly classified into two types: embryonic stem cells (ESCs) and adult stem cells. In terms of differentiation potential, ESCs are pluripotent and adult stem cells are multipotent. Amnion, which is a membranous sac that contains the fetus and amniotic fluid and functions in protecting the developing embryo during gestation, is another stem cell source. Amnion-derived stem cells are classified as human amniotic membrane-derived epithelial stem cells, human amniotic membrane-derived mesenchymal stem cells and human amniotic fluid-derived stem cells. They are in an intermediate stage between pluripotent ESCs and lineage-restricted adult stem cells, non-tumorigenic, and contribute to low immunogenicity and anti-inflammation. Furthermore, they are easily available and do not cause any controversial issues in their recovery and applications. Not only are amnion-derived stem cells applicable in regenerative medicine, they have anticancer capacity. In non-engineered stem cells transplantation strategies, amnion-derived stem cells effectively target the tumor and suppressed the tumor growth by expressing cytotoxic cytokines. Additionally, they also have a potential as novel delivery vehicles transferring therapeutic genes to the cancer formation sites in gene-directed enzyme/prodrug combination therapy. Owing to their own advantageous properties, amnion-derived stem cells are emerging as a new candidate in anticancer therapy.

2.32 THz quantum cascade laser frequency-locked to the harmonic of a microwave synthesizer source.

PubMed

Danylov, Andriy A; Light, Alexander R; Waldman, Jerry; Erickson, Neal R; Qian, Xifeng; Goodhue, William D

2012-12-03

Frequency stabilization of a THz quantum cascade laser (QCL) to the harmonic of a microwave source has been accomplished using a Schottky diode waveguide mixer designed for harmonic mixing. The 2.32 THz, 1.0 milliwatt CW QCL is coupled into the signal port of the mixer and a 110 GHz signal, derived from a harmonic of a microwave synthesizer, is coupled into the IF port. The difference frequency between the 21st harmonic of 110 GHz and the QCL is used in a discriminator to adjust the QCL bias current to stabilize the frequency. The short-term frequency jitter is reduced from 550 kHz to 4.5 kHz (FWHM) and the long-term frequency drift is eliminated. This performance is compared to that of several other THz QCL frequency stabilization techniques.

Coarse Grid CFD for underresolved simulation

NASA Astrophysics Data System (ADS)

Class, Andreas G.; Viellieber, Mathias O.; Himmel, Steffen R.

2010-11-01

CFD simulation of the complete reactor core of a nuclear power plant requires exceedingly huge computational resources so that this crude power approach has not been pursued yet. The traditional approach is 1D subchannel analysis employing calibrated transport models. Coarse grid CFD is an attractive alternative technique based on strongly under-resolved CFD and the inviscid Euler equations. Obviously, using inviscid equations and coarse grids does not resolve all the physics requiring additional volumetric source terms modelling viscosity and other sub-grid effects. The source terms are implemented via correlations derived from fully resolved representative simulations which can be tabulated or computed on the fly. The technique is demonstrated for a Carnot diffusor and a wire-wrap fuel assembly [1]. [4pt] [1] Himmel, S.R. phd thesis, Stuttgart University, Germany 2009, http://bibliothek.fzk.de/zb/berichte/FZKA7468.pdf

Evaluation of forest disturbance legacy effects on dissolved organic matter characteristics in streams at the Hubbard Brook Experimental Forest, New Hampshire

Treesearch

Kaelin M. Cawley; John Campbell; Melissa Zwilling; Rudolf. Jaffé

2014-01-01

Dissolved organic matter (DOM) source and composition are critical drivers of its reactivity, impact microbial food webs and influence ecosystem functions. It is believed that DOM composition and abundance represent an integrated signal derived from the surrounding watershed. Recent studies have shown that land-use may have a long-term effect on DOM composition....

Consistent description of kinetic equation with triangle anomaly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pu Shi; Gao Jianhua; Wang Qun

2011-05-01

We provide a consistent description of the kinetic equation with a triangle anomaly which is compatible with the entropy principle of the second law of thermodynamics and the charge/energy-momentum conservation equations. In general an anomalous source term is necessary to ensure that the equations for the charge and energy-momentum conservation are satisfied and that the correction terms of distribution functions are compatible to these equations. The constraining equations from the entropy principle are derived for the anomaly-induced leading order corrections to the particle distribution functions. The correction terms can be determined for the minimum number of unknown coefficients in onemore » charge and two charge cases by solving the constraining equations.« less

Derivation of the linear-logistic model and Cox's proportional hazard model from a canonical system description.

PubMed

Voit, E O; Knapp, R G

1997-08-15

The linear-logistic regression model and Cox's proportional hazard model are widely used in epidemiology. Their successful application leaves no doubt that they are accurate reflections of observed disease processes and their associated risks or incidence rates. In spite of their prominence, it is not a priori evident why these models work. This article presents a derivation of the two models from the framework of canonical modeling. It begins with a general description of the dynamics between risk sources and disease development, formulates this description in the canonical representation of an S-system, and shows how the linear-logistic model and Cox's proportional hazard model follow naturally from this representation. The article interprets the model parameters in terms of epidemiological concepts as well as in terms of general systems theory and explains the assumptions and limitations generally accepted in the application of these epidemiological models.

Solving ill-posed control problems by stabilized finite element methods: an alternative to Tikhonov regularization

NASA Astrophysics Data System (ADS)

Burman, Erik; Hansbo, Peter; Larson, Mats G.

2018-03-01

Tikhonov regularization is one of the most commonly used methods for the regularization of ill-posed problems. In the setting of finite element solutions of elliptic partial differential control problems, Tikhonov regularization amounts to adding suitably weighted least squares terms of the control variable, or derivatives thereof, to the Lagrangian determining the optimality system. In this note we show that the stabilization methods for discretely ill-posed problems developed in the setting of convection-dominated convection-diffusion problems, can be highly suitable for stabilizing optimal control problems, and that Tikhonov regularization will lead to less accurate discrete solutions. We consider some inverse problems for Poisson’s equation as an illustration and derive new error estimates both for the reconstruction of the solution from the measured data and reconstruction of the source term from the measured data. These estimates include both the effect of the discretization error and error in the measurements.

Enhanced Elliptic Grid Generation

NASA Technical Reports Server (NTRS)

Kaul, Upender K.

2007-01-01

An enhanced method of elliptic grid generation has been invented. Whereas prior methods require user input of certain grid parameters, this method provides for these parameters to be determined automatically. "Elliptic grid generation" signifies generation of generalized curvilinear coordinate grids through solution of elliptic partial differential equations (PDEs). Usually, such grids are fitted to bounding bodies and used in numerical solution of other PDEs like those of fluid flow, heat flow, and electromagnetics. Such a grid is smooth and has continuous first and second derivatives (and possibly also continuous higher-order derivatives), grid lines are appropriately stretched or clustered, and grid lines are orthogonal or nearly so over most of the grid domain. The source terms in the grid-generating PDEs (hereafter called "defining" PDEs) make it possible for the grid to satisfy requirements for clustering and orthogonality properties in the vicinity of specific surfaces in three dimensions or in the vicinity of specific lines in two dimensions. The grid parameters in question are decay parameters that appear in the source terms of the inhomogeneous defining PDEs. The decay parameters are characteristic lengths in exponential- decay factors that express how the influences of the boundaries decrease with distance from the boundaries. These terms govern the rates at which distance between adjacent grid lines change with distance from nearby boundaries. Heretofore, users have arbitrarily specified decay parameters. However, the characteristic lengths are coupled with the strengths of the source terms, such that arbitrary specification could lead to conflicts among parameter values. Moreover, the manual insertion of decay parameters is cumbersome for static grids and infeasible for dynamically changing grids. In the present method, manual insertion and user specification of decay parameters are neither required nor allowed. Instead, the decay parameters are determined automatically as part of the solution of the defining PDEs. Depending on the shape of the boundary segments and the physical nature of the problem to be solved on the grid, the solution of the defining PDEs may provide for rates of decay to vary along and among the boundary segments and may lend itself to interpretation in terms of one or more physical quantities associated with the problem.

Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers.

PubMed

Macias, Maria I; Grande, Jesús; Moreno, Ana; Domínguez, Irene; Bornstein, Rafael; Flores, Ana I

2010-11-01

The objective of the study was to isolate and characterize a population of mesenchymal stem cells (MSCs) from human term placental membranes. We isolated an adherent cell population from extraembryonic membranes. Morphology, phenotype, growth characteristics, karyotype, and immunological and differentiation properties were analyzed. The isolated placental MSCs were from maternal origin and named as decidua-derived mesenchymal stem cells (DMSCs). DMSCs differentiated into derivatives of all germ layers. It is the first report about placental MSC differentiation into alveolar type II cells. Clonally expanded DMSCs differentiated into all embryonic layers, including pulmonary cells. DMSCs showed higher life span than placental cells from fetal origin and proliferated without genomic instability. The data suggest that DMSCs are true multipotent MSCs, distinguishing them from other placental MSCs. DMSCs could be safely used in the mother as a potential source of MSCs for pelvic floor dysfunctions and immunological diseases. Additionally, frozen DMSCs can be stored for both autologous and allogeneic tissue regeneration. Copyright © 2010 Mosby, Inc. All rights reserved.

The lightest organic radical cation for charge storage in redox flow batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Jinhua; Pan, Baofei; Duan, Wentao

2016-08-25

Electrochemically reversible fluids of high energy density are promising materials for capturing the electrical energy generated from intermittent sources like solar and wind. To meet this technological challenge there is a need to understand the fundamental limits and interplay of electrochemical potential, stability and solubility in “lean” derivatives of redox-active molecules. Here we describe the process of molecular pruning, illustrated for 2,5-di-tert-butyl-1,4-bis(2-methoxyethoxy)benzene, a molecule known to produce a persistently stable, high-potential radical cation. By systematically shedding molecular fragments considered important for radical cation steric stabilization, we discovered a minimalistic structure that retains long-term stability in its oxidized form. Interestingly, wemore » find the tert-butyl groups are unnecessary; high stability of the radical cation and high solubility are both realized in derivatives having appropriately positioned arene methyl groups. These stability trends are rationalized by mechanistic considerations of the postulated decomposition pathways. We suggest that the molecular pruning approach will uncover lean redox active derivatives for electrochemical energy storage leading to materials with long-term stability and high intrinsic capacity.« less

Understanding the electrical behavior of the action potential in terms of elementary electrical sources.

PubMed

Rodriguez-Falces, Javier

2015-03-01

A concept of major importance in human electrophysiology studies is the process by which activation of an excitable cell results in a rapid rise and fall of the electrical membrane potential, the so-called action potential. Hodgkin and Huxley proposed a model to explain the ionic mechanisms underlying the formation of action potentials. However, this model is unsuitably complex for teaching purposes. In addition, the Hodgkin and Huxley approach describes the shape of the action potential only in terms of ionic currents, i.e., it is unable to explain the electrical significance of the action potential or describe the electrical field arising from this source using basic concepts of electromagnetic theory. The goal of the present report was to propose a new model to describe the electrical behaviour of the action potential in terms of elementary electrical sources (in particular, dipoles). The efficacy of this model was tested through a closed-book written exam. The proposed model increased the ability of students to appreciate the distributed character of the action potential and also to recognize that this source spreads out along the fiber as function of space. In addition, the new approach allowed students to realize that the amplitude and sign of the extracellular electrical potential arising from the action potential are determined by the spatial derivative of this intracellular source. The proposed model, which incorporates intuitive graphical representations, has improved students' understanding of the electrical potentials generated by bioelectrical sources and has heightened their interest in bioelectricity. Copyright © 2015 The American Physiological Society.

The winds of the comparison data set for the Seasat Gulf of Alaska Experiment

NASA Technical Reports Server (NTRS)

Pierson, W. J.; Peteherych, S.; Wilkerson, J. C.

1980-01-01

Ship and data buoy winds used for comparison in the validation of Seasat-derived winds are described in terms of the time series of hourly wind observations from the buoys and in terms of the techniques used to produce 20- and 30-min average winds from the ships. Attention is given to the comparison data, the synoptic scale wind, turbulence concepts, the data buoy winds, Ocean Weather Station PAPA, the oceanographer data, and the results from Ocean Station PAPA Ship Quadra and from the oceanographer. Sources of scatter in the comparison data are reviewed.

Rayleigh, the unit for light radiance.

PubMed

Baker, D J

1974-09-01

A 0.7% accurate formula is derived for the easy conversion of power spectral radiance L(lambda) in W cm(-2) sr(-1) microm(-1)to rayleigh spectral radiance R(lambda) in rayleigh/microm, R(lambda) = 2pilambdaL(lambda) x 10(13), where the wavelength lambda is in microm. The rationale for the rayleigh unit is discussed in terms of a photon rate factor and a solid angle factor. The latter is developed in terms of an equivalence theorem about optical receivers and extended sources, and the concept is extended to the computation of photon volume emission rates from altitude profiles of zenith radiance.

Fermi large area telescope second source catalog

DOE PAGES

Nolan, P. L.; Abdo, A. A.; Ackermann, M.; ...

2012-03-28

Here, we present the second catalog of high-energy γ-ray sources detected by the Large Area Telescope (LAT), the primary science instrument on the Fermi Gamma-ray Space Telescope (Fermi), derived from data taken during the first 24 months of the science phase of the mission, which began on 2008 August 4. Source detection is based on the average flux over the 24 month period. The second Fermi-LAT catalog (2FGL) includes source location regions, defined in terms of elliptical fits to the 95% confidence regions and spectral fits in terms of power-law, exponentially cutoff power-law, or log-normal forms. Also included are fluxmore » measurements in five energy bands and light curves on monthly intervals for each source. Twelve sources in the catalog are modeled as spatially extended. Furthermore, we provide a detailed comparison of the results from this catalog with those from the first Fermi-LAT catalog (1FGL). Although the diffuse Galactic and isotropic models used in the 2FGL analysis are improved compared to the 1FGL catalog, we attach caution flags to 162 of the sources to indicate possible confusion with residual imperfections in the diffuse model. Finally, the 2FGL catalog contains 1873 sources detected and characterized in the 100 MeV to 100 GeV range of which we consider 127 as being firmly identified and 1171 as being reliably associated with counterparts of known or likely γ-ray-producing source classes.« less

FERMI LARGE AREA TELESCOPE SECOND SOURCE CATALOG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nolan, P. L.; Ajello, M.; Allafort, A.

We present the second catalog of high-energy {gamma}-ray sources detected by the Large Area Telescope (LAT), the primary science instrument on the Fermi Gamma-ray Space Telescope (Fermi), derived from data taken during the first 24 months of the science phase of the mission, which began on 2008 August 4. Source detection is based on the average flux over the 24 month period. The second Fermi-LAT catalog (2FGL) includes source location regions, defined in terms of elliptical fits to the 95% confidence regions and spectral fits in terms of power-law, exponentially cutoff power-law, or log-normal forms. Also included are flux measurementsmore » in five energy bands and light curves on monthly intervals for each source. Twelve sources in the catalog are modeled as spatially extended. We provide a detailed comparison of the results from this catalog with those from the first Fermi-LAT catalog (1FGL). Although the diffuse Galactic and isotropic models used in the 2FGL analysis are improved compared to the 1FGL catalog, we attach caution flags to 162 of the sources to indicate possible confusion with residual imperfections in the diffuse model. The 2FGL catalog contains 1873 sources detected and characterized in the 100 MeV to 100 GeV range of which we consider 127 as being firmly identified and 1171 as being reliably associated with counterparts of known or likely {gamma}-ray-producing source classes.« less

Hydrodynamic Controls on Archaeal Tetraether Lipid Compositions in Washington Margin Sediments: Insights From Compound-Specific Radiocarbon Measurements

NASA Astrophysics Data System (ADS)

Uchida, M.; Eglinton, T. I.; Montlucon, D. B.; Pearson, A.; Hayes, J. M.

2008-12-01

Continental margin sediments represent a large sink of organic carbon derived from marine and terrestrial sources. Archaeal glycerol dibiphytanyl glycerol tetraether lipids (GDGTs) are derived from both marine and terrestrial sources and have been used both for reconstruction of paleo sea surface temperatures and as an index of terrestrial carbon input to the marine sediments. However, the sources and modes of supply as well as the preservation of GDGTs in marginal sediments are poorly understood. The distribution and deposition of GDGTs is further complicated by hydrodynamic processes. We have analyzed a suite of surface sediment samples collected along a transect from the mouth of the Columbia River, across the Washington Margin, to the Cascadia Basin in the northeast Pacific Ocean. Sediments were separated according to their grain size and hydrodynamic properties, and the organic matter characterized in terms of its bulk elemental, isotopic, and molecular properties. Here we present radiocarbon measurements on individual GDGTs, alkenones, and fatty acids from size-fractionated sediments from shelf and slope sediments, and discuss the results in the context of previous studies of the molecular abundances and isotopic compositions of sedimentary organic matter for in this region. Systematic variations in elemental, isotopic and molecular-level composition are observed across the different particle classes. Moreover, these variations are manifested in the isotopic composition of different molecular markers of both marine and terrestrial sources organic matter. Both marine-derived lipids, including alkenones and marine archaeal tetraethers, and soil microbe-derived tetraether lipids show strong distributional and isotopic variations among the size-fractionated sediments. These variations in terrestrial and marine biomarker properties inform on the sources, particle dynamics, and transport history of organic matter buried on river-influenced continental margins. The implications of these findings for the application of molecular markers as proxies of organic matter input, and on the interpretation of past marine and continental environmental conditions from sedimentary records will also be discussed.

Remnants of an Ancient Deltaretrovirus in the Genomes of Horseshoe Bats (Rhinolophidae).

PubMed

Hron, Tomáš; Farkašová, Helena; Gifford, Robert J; Benda, Petr; Hulva, Pavel; Görföl, Tamás; Pačes, Jan; Elleder, Daniel

2018-04-10

Endogenous retrovirus (ERV) sequences provide a rich source of information about the long-term interactions between retroviruses and their hosts. However, most ERVs are derived from a subset of retrovirus groups, while ERVs derived from certain other groups remain extremely rare. In particular, only a single ERV sequence has been identified that shows evidence of being related to an ancient Deltaretrovirus , despite the large number of vertebrate genome sequences now available. In this report, we identify a second example of an ERV sequence putatively derived from a past deltaretroviral infection, in the genomes of several species of horseshoe bats (Rhinolophidae). This sequence represents a fragment of viral genome derived from a single integration. The time of the integration was estimated to be 11-19 million years ago. This finding, together with the previously identified endogenous Deltaretrovirus in long-fingered bats (Miniopteridae), suggest a close association of bats with ancient deltaretroviruses.

Precision Orbit Derived Atmospheric Density: Development and Performance

NASA Astrophysics Data System (ADS)

McLaughlin, C.; Hiatt, A.; Lechtenberg, T.; Fattig, E.; Mehta, P.

2012-09-01

Precision orbit ephemerides (POE) are used to estimate atmospheric density along the orbits of CHAMP (Challenging Minisatellite Payload) and GRACE (Gravity Recovery and Climate Experiment). The densities are calibrated against accelerometer derived densities and considering ballistic coefficient estimation results. The 14-hour density solutions are stitched together using a linear weighted blending technique to obtain continuous solutions over the entire mission life of CHAMP and through 2011 for GRACE. POE derived densities outperform the High Accuracy Satellite Drag Model (HASDM), Jacchia 71 model, and NRLMSISE-2000 model densities when comparing cross correlation and RMS with accelerometer derived densities. Drag is the largest error source for estimating and predicting orbits for low Earth orbit satellites. This is one of the major areas that should be addressed to improve overall space surveillance capabilities; in particular, catalog maintenance. Generally, density is the largest error source in satellite drag calculations and current empirical density models such as Jacchia 71 and NRLMSISE-2000 have significant errors. Dynamic calibration of the atmosphere (DCA) has provided measurable improvements to the empirical density models and accelerometer derived densities of extremely high precision are available for a few satellites. However, DCA generally relies on observations of limited accuracy and accelerometer derived densities are extremely limited in terms of measurement coverage at any given time. The goal of this research is to provide an additional data source using satellites that have precision orbits available using Global Positioning System measurements and/or satellite laser ranging. These measurements strike a balance between the global coverage provided by DCA and the precise measurements of accelerometers. The temporal resolution of the POE derived density estimates is around 20-30 minutes, which is significantly worse than that of accelerometer derived density estimates. However, major variations in density are observed in the POE derived densities. These POE derived densities in combination with other data sources can be assimilated into physics based general circulation models of the thermosphere and ionosphere with the possibility of providing improved density forecasts for satellite drag analysis. POE derived density estimates were initially developed using CHAMP and GRACE data so comparisons could be made with accelerometer derived density estimates. This paper presents the results of the most extensive calibration of POE derived densities compared to accelerometer derived densities and provides the reasoning for selecting certain parameters in the estimation process. The factors taken into account for these selections are the cross correlation and RMS performance compared to the accelerometer derived densities and the output of the ballistic coefficient estimation that occurs simultaneously with the density estimation. This paper also presents the complete data set of CHAMP and GRACE results and shows that the POE derived densities match the accelerometer densities better than empirical models or DCA. This paves the way to expand the POE derived densities to include other satellites with quality GPS and/or satellite laser ranging observations.

The proposed terminology 'A(1c)-derived average glucose' is inherently imprecise and should not be adopted.

PubMed

Bloomgarden, Z T; Inzucchi, S E; Karnieli, E; Le Roith, D

2008-07-01

The proposed use of a more precise standard for glycated (A(1c)) and non-glycated haemoglobin would lead to an A(1c) value, when expressed as a percentage, that is lower than that currently in use. One approach advocated to address the potential confusion that would ensue is to replace 'HbA(1c)' with a new term, 'A(1c)-derived average glucose.' We review evidence from several sources suggesting that A(1c) is, in fact, inherently imprecise as a measure of average glucose, so that the proposed terminology should not be adopted.

Derivation of error sources for experimentally derived heliostat shapes

NASA Astrophysics Data System (ADS)

Cumpston, Jeff; Coventry, Joe

2017-06-01

Data gathered using photogrammetry that represents the surface and structure of a heliostat mirror panel is investigated in detail. A curve-fitting approach that allows the retrieval of four distinct mirror error components, while prioritizing the best fit possible to paraboloidal terms in the curve fitting equation, is presented. The angular errors associated with each of the four surfaces are calculated, and the relative magnitude for each of them is given. It is found that in this case, the mirror had a significant structural twist, and an estimate of the improvement to the mirror surface quality in the case of no twist was made.

Performance evaluation of the Champagne source reconstruction algorithm on simulated and real M/EEG data.

PubMed

Owen, Julia P; Wipf, David P; Attias, Hagai T; Sekihara, Kensuke; Nagarajan, Srikantan S

2012-03-01

In this paper, we present an extensive performance evaluation of a novel source localization algorithm, Champagne. It is derived in an empirical Bayesian framework that yields sparse solutions to the inverse problem. It is robust to correlated sources and learns the statistics of non-stimulus-evoked activity to suppress the effect of noise and interfering brain activity. We tested Champagne on both simulated and real M/EEG data. The source locations used for the simulated data were chosen to test the performance on challenging source configurations. In simulations, we found that Champagne outperforms the benchmark algorithms in terms of both the accuracy of the source localizations and the correct estimation of source time courses. We also demonstrate that Champagne is more robust to correlated brain activity present in real MEG data and is able to resolve many distinct and functionally relevant brain areas with real MEG and EEG data. Copyright © 2011 Elsevier Inc. All rights reserved.

Limitations of the isotopic composition of nitrates as a tracer of their origin

NASA Astrophysics Data System (ADS)

Kloppmann, Wolfram; Mayer, Bernhard; Otero, Neus; Sebilo, Mathieu; Gooddy, Daren; Lapworth, Dan; Surridge, Ben; Petelet Giraud, Emmanuelle; Flehoc, Christine; Baran, Nicole

2017-04-01

Nitrogen and oxygen isotopes are traditionally considered and frequently used as tracers of nitrate sources in watersheds used for drinking water production. The enrichment of synthetic nitrate-containing fertilizers in 18O due to the contribution of atmospheric oxygen in the production process confers a specific isotopic fingerprint to mineral fertilizers. In spite of the still widespread use on nitrate-containing synthetic fertilizers, their characteristic N and O isotope signatures are rarely unambiguously observed in nitrate-contaminated groundwater. We postulate, in line with Mengis et al. (2001), that fertilizer-derived nitrate is not directly and rapidly transferred to groundwater but rather retained in the soil-plant system as organic N and then mineralized and re-oxidized (termed the mineralization-immobilization turnover, MIT) thereby re-setting the oxygen isotope composition of nitrate and also changing its N isotope ratios. We show examples from watersheds on diverse alluvial/clastic and carbonate aquifers in eastern and northern France where, in spite of the use of mineral fertilizers, evidenced also through other isotopic tracers (boron isotopes), both N and O-isotope ratios are very homogeneous and compatible with nitrification of ammonium where 2/3 of oxygen is derived from soil water and 1/3 from atmospheric O2. These field data are corroborated by lysimeter data from Canada. Even if in areas where ammonium is derived from chemical fertilizers, N values still tend to be lower than in areas where ammonium is derived from manure/sewage, this is clearly a limitation to the dual isotope method (N, O) for nitrate source identification, but has important implications for the nitrogen mobility and residence time in soils amended with synthetic fertilizers (Sebilo et al., 2013). Mengis M., Walther U., Bernasconi S. M., Wehrli B. (2001) Limitations of Using δ18O for the Source Identification of Nitrate in Agricultural Soils. Environmental Science & Technology, 35, 1840-1844. Sebilo M., Mayer B., Nicolardot B., Pinay G., Mariotti A. (2013) Long-term fate of nitrate fertilizer in agricultural soils. Proceedings of the National Academy of Sciences of the United States of America, 110, 18185-18189.

The Analytic Information Warehouse (AIW): a Platform for Analytics using Electronic Health Record Data

PubMed Central

Post, Andrew R.; Kurc, Tahsin; Cholleti, Sharath; Gao, Jingjing; Lin, Xia; Bornstein, William; Cantrell, Dedra; Levine, David; Hohmann, Sam; Saltz, Joel H.

2013-01-01

Objective To create an analytics platform for specifying and detecting clinical phenotypes and other derived variables in electronic health record (EHR) data for quality improvement investigations. Materials and Methods We have developed an architecture for an Analytic Information Warehouse (AIW). It supports transforming data represented in different physical schemas into a common data model, specifying derived variables in terms of the common model to enable their reuse, computing derived variables while enforcing invariants and ensuring correctness and consistency of data transformations, long-term curation of derived data, and export of derived data into standard analysis tools. It includes software that implements these features and a computing environment that enables secure high-performance access to and processing of large datasets extracted from EHRs. Results We have implemented and deployed the architecture in production locally. The software is available as open source. We have used it as part of hospital operations in a project to reduce rates of hospital readmission within 30 days. The project examined the association of over 100 derived variables representing disease and co-morbidity phenotypes with readmissions in five years of data from our institution’s clinical data warehouse and the UHC Clinical Database (CDB). The CDB contains administrative data from over 200 hospitals that are in academic medical centers or affiliated with such centers. Discussion and Conclusion A widely available platform for managing and detecting phenotypes in EHR data could accelerate the use of such data in quality improvement and comparative effectiveness studies. PMID:23402960

The prediction of the noise of supersonic propellers in time domain - New theoretical results

NASA Technical Reports Server (NTRS)

Farassat, F.

1983-01-01

In this paper, a new formula for the prediction of the noise of supersonic propellers is derived in the time domain which is superior to the previous formulations in several respects. The governing equation is based on the Ffowcs Williams-Hawkings (FW-H) equation with the thickness source term replaced by an equivalent loading source term derived by Isom (1975). Using some results of generalized function theory and simple four-dimensional space-time geometry, the formal solution of the governing equation is manipulated to a form requiring only the knowledge of blade surface pressure data and geometry. The final form of the main result of this paper consists of some surface and line integrals. The surface integrals depend on the surface pressure, time rate of change of surface pressure, and surface pressure gradient. These integrals also involve blade surface curvatures. The line integrals which depend on local surface pressure are along the trailing edge, the shock traces on the blade, and the perimeter of the airfoil section at the inner radius of the blade. The new formulation is for the full blade surface and does not involve any numerical observer time differentiation. The method of implementation on a computer for numerical work is also discussed.

Long-Term Spectral and Timing Behavior of the Black Hole Candidate XTE J1908+094

NASA Technical Reports Server (NTRS)

Gogus, Ersin; Finger, Mark H.; Kouveliotou, Chryssa; Woods, Peter M.; Patel, Sandeep K.; Ruppen, Michael; Swank, Jean H.; Markwardt, Craig B.; VanDerKlis, Michiel

2004-01-01

We present the long-term X-ray light curves and detailed spectral and timing analyses of XTE J1908+094 using the Rossi X-Ray Timing Explorer Proportional Counter Array observations covering two outbursts in 2002 and early 2003. At the onset of the first outburst, the source was found in a spectrally low/hard state lasting for approx.40 days, followed by a 3 day long transition to the high/soft state. The source flux (in 2- 10 keV) reached approx.100 mcrab on 2002 April 6, then decayed rapidly. In power spectra, we detect strong band-limited noise and varying low- frequency quasi-periodic oscillations that evolved from approx.0.5 to approx.5 Hz during the initial low/hard state of the source. We find that the second outburst closely resembled the spectral evolution of the first. The X-ray transient s overall outburst characteristics led us to classify XTE J1908+094 as a black hole candidate. Here we also derive precise X-ray position of the source using Chandra observations that were performed during the decay phase of the first outburst and following the second outburst.

Darwin Core: An Evolving Community-Developed Biodiversity Data Standard

PubMed Central

Wieczorek, John; Bloom, David; Guralnick, Robert; Blum, Stan; Döring, Markus; Giovanni, Renato; Robertson, Tim; Vieglais, David

2012-01-01

Biodiversity data derive from myriad sources stored in various formats on many distinct hardware and software platforms. An essential step towards understanding global patterns of biodiversity is to provide a standardized view of these heterogeneous data sources to improve interoperability. Fundamental to this advance are definitions of common terms. This paper describes the evolution and development of Darwin Core, a data standard for publishing and integrating biodiversity information. We focus on the categories of terms that define the standard, differences between simple and relational Darwin Core, how the standard has been implemented, and the community processes that are essential for maintenance and growth of the standard. We present case-study extensions of the Darwin Core into new research communities, including metagenomics and genetic resources. We close by showing how Darwin Core records are integrated to create new knowledge products documenting species distributions and changes due to environmental perturbations. PMID:22238640

Nomenclature in laboratory robotics and automation (IUPAC Recommendation 1994)

PubMed Central

(Skip) Kingston, H. M.; Kingstonz, M. L.

1994-01-01

These recommended terms have been prepared to help provide a uniform approach to terminology and notation in laboratory automation and robotics. Since the terminology used in laboratory automation and robotics has been derived from diverse backgrounds, it is often vague, imprecise, and in some cases, in conflict with classical automation and robotic nomenclature. These dejinitions have been assembled from standards, monographs, dictionaries, journal articles, and documents of international organizations emphasizing laboratory and industrial automation and robotics. When appropriate, definitions have been taken directly from the original source and identified with that source. However, in some cases no acceptable definition could be found and a new definition was prepared to define the object, term, or action. Attention has been given to defining specific robot types, coordinate systems, parameters, attributes, communication protocols and associated workstations and hardware. Diagrams are included to illustrate specific concepts that can best be understood by visualization. PMID:18924684

Volume Averaging Study of the Capacitive Deionization Process in Homogeneous Porous Media

DOE PAGES

Gabitto, Jorge; Tsouris, Costas

2015-05-05

Ion storage in porous electrodes is important in applications such as energy storage by supercapacitors, water purification by capacitive deionization, extraction of energy from a salinity difference and heavy ion purification. In this paper, a model is presented to simulate the charge process in homogeneous porous media comprising big pores. It is based on a theory for capacitive charging by ideally polarizable porous electrodes without faradaic reactions or specific adsorption of ions. A volume averaging technique is used to derive the averaged transport equations in the limit of thin electrical double layers. Transport between the electrolyte solution and the chargedmore » wall is described using the Gouy–Chapman–Stern model. The effective transport parameters for isotropic porous media are calculated solving the corresponding closure problems. Finally, the source terms that appear in the average equations are calculated using numerical computations. An alternative way to deal with the source terms is proposed.« less

A 305 year monthly rainfall series for the Island of Ireland (1711-2016)

NASA Astrophysics Data System (ADS)

Murphy, Conor; Burt, Tim P.; Broderick, Ciaran; Duffy, Catriona; Macdonald, Neil; Matthews, Tom; McCarthy, Mark P.; Mullan, Donal; Noone, Simon; Ryan, Ciara; Thorne, Peter; Walsh, Seamus; Wilby, Robert L.

2017-04-01

This paper derives a continuous 305-year monthly rainfall series for the Island of Ireland (IoI) for the period 1711-2016. Two key data sources are employed: i) a previously unpublished UK Met Office Note which compiled annual rainfall anomalies and corresponding monthly per mille amounts from weather diaries and early observational records for the period 1711-1977; and ii) a long-term, homogenised monthly IoI rainfall series for the period 1850-2016. Using estimates of long-term average precipitation sampled from the quality assured series, the full record is reconstituted and insights drawn regarding notable periods and the range of climate variability and change experienced. Consistency with other long records for the region is examined, including: the England and Wales Precipitation series (EWP; 1766-2016); the early EWP Glasspoole series (1716-1765) and the Central England Temperature series (CET; 1711-2016). Strong correspondence between all records is noted from 1780 onwards. While disparities are evident between the early EWP and Ireland series, the latter shows strong decadal consistency with CET throughout the record. In addition, independent, early observations from Cork and Dublin, along with available documentary sources, corroborate the derived series and add confidence to our reconstruction. The new IoI rainfall record reveals that the wettest decades occurred in the early 18th Century, despite the fact that IoI has experienced a long-term winter wetting trend consistent with climate model projections. These exceptionally wet winters of the 1720s and 1730s were concurrent with almost unprecedented warmth in the CET, glacial advance throughout Scandinavia, and glacial retreat in West Greenland, consistent with a wintertime NAO-type forcing. Our study therefore demonstrates the value of long-term observational records for providing insight to the natural climate variability of the North Atlantic region.

Advanced relativistic VLBI model for geodesy

NASA Astrophysics Data System (ADS)

Soffel, Michael; Kopeikin, Sergei; Han, Wen-Biao

2017-07-01

Our present relativistic part of the geodetic VLBI model for Earthbound antennas is a consensus model which is considered as a standard for processing high-precision VLBI observations. It was created as a compromise between a variety of relativistic VLBI models proposed by different authors as documented in the IERS Conventions 2010. The accuracy of the consensus model is in the picosecond range for the group delay but this is not sufficient for current geodetic purposes. This paper provides a fully documented derivation of a new relativistic model having an accuracy substantially higher than one picosecond and based upon a well accepted formalism of relativistic celestial mechanics, astrometry and geodesy. Our new model fully confirms the consensus model at the picosecond level and in several respects goes to a great extent beyond it. More specifically, terms related to the acceleration of the geocenter are considered and kept in the model, the gravitational time-delay due to a massive body (planet, Sun, etc.) with arbitrary mass and spin-multipole moments is derived taking into account the motion of the body, and a new formalism for the time-delay problem of radio sources located at finite distance from VLBI stations is presented. Thus, the paper presents a substantially elaborated theoretical justification of the consensus model and its significant extension that allows researchers to make concrete estimates of the magnitude of residual terms of this model for any conceivable configuration of the source of light, massive bodies, and VLBI stations. The largest terms in the relativistic time delay which can affect the current VLBI observations are from the quadrupole and the angular momentum of the gravitating bodies that are known from the literature. These terms should be included in the new geodetic VLBI model for improving its consistency.

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation.

PubMed

Reinisch, Andreas; Etchart, Nathalie; Thomas, Daniel; Hofmann, Nicole A; Fruehwirth, Margareta; Sinha, Subarna; Chan, Charles K; Senarath-Yapa, Kshemendra; Seo, Eun-Young; Wearda, Taylor; Hartwig, Udo F; Beham-Schmid, Christine; Trajanoski, Slave; Lin, Qiong; Wagner, Wolfgang; Dullin, Christian; Alves, Frauke; Andreeff, Michael; Weissman, Irving L; Longaker, Michael T; Schallmoser, Katharina; Majeti, Ravindra; Strunk, Dirk

2015-01-08

In the last decade there has been a rapid expansion in clinical trials using mesenchymal stromal cells (MSCs) from a variety of tissues. However, despite similarities in morphology, immunophenotype, and differentiation behavior in vitro, MSCs sourced from distinct tissues do not necessarily have equivalent biological properties. We performed a genome-wide methylation, transcription, and in vivo evaluation of MSCs from human bone marrow (BM), white adipose tissue, umbilical cord, and skin cultured in humanized media. Surprisingly, only BM-derived MSCs spontaneously formed a BM cavity through a vascularized cartilage intermediate in vivo that was progressively replaced by hematopoietic tissue and bone. Only BM-derived MSCs exhibited a chondrogenic transcriptional program with hypomethylation and increased expression of RUNX3, RUNX2, BGLAP, MMP13, and ITGA10 consistent with a latent and primed skeletal developmental potential. The humanized MSC-derived microenvironment permitted homing and maintenance of long-term murine SLAM(+) hematopoietic stem cells (HSCs), as well as human CD34(+)/CD38(-)/CD90(+)/CD45RA(+) HSCs after cord blood transplantation. These studies underscore the profound differences in developmental potential between MSC sources independent of donor age, with implications for their clinical use. We also demonstrate a tractable human niche model for studying homing and engraftment of human hematopoietic cells in normal and neoplastic states. © 2015 by The American Society of Hematology.

Catalytic transformations of biomass substrates using mixed metal oxides derived from substituted hydrotalcites

NASA Astrophysics Data System (ADS)

Macala, Gerald Stephen, II

Fueled by seemingly endless reserves of cheap and easily accessible fossil energy, the industrial age has brought to the developed world tremendous advances in human health and well being. Unfortunately the burning of fossil fuels has also been implicated in increasing atmospheric CO2 concentrations and global climate change. Concerns about short-term and long-term supply further build a case for the need for alternative energy sources. Biomass derived materials are a tantalizing source of fuels and fine chemicals. Unlike petroleum derived hydrocarbons, biomass can be both renewable and carbon neutral. Crops can be regenerated annually or even more often in tropical climates, and since the captured carbon originates as atmospheric CO2, the overall cycle has the potential to be nearly carbon neutral regardless of the final fate of the carbon. In contrast to petroleum derived hydrocarbons, which can often be made more valuable by adding functionality, biomass derived materials are already highly functionalized and can usually be made more valuable by selective removal of functionality. The development of robust catalysts capable of selective defuntionalization of biomass derived substrates remains an important challenge with potentially enormous economic and societal impact. In addition to being robust and selective, catalysts should preferably be heterogeneous to allow for easier removal and regeneration after the reaction is complete. New materials consisting of Mg-Al hydrotalcite-like structures, with a limiting percentage of Mg or Al substituted with other M2+ or M3+ cations, were synthesized by a co-precipitation process in basic aqueous solution with carbonate as counterion. Calcination of these materials at 460 °C resulted in evolution of CO2 and water and yielded high surface area mixed metal oxides with enhanced reactivity. Materials were characterized by ICP for elemental analysis, XRD for structural information, XPS for surface elemental analysis and TEM for morphology. Substituting some of the Al for ferric ion resulted in enhanced basicity and enhanced reactivity towards transesterification of seed oil and the model compound triacetin. Substituting some of the Mg for cupric ion resulted in a transfer hydrogenation catalyst capable of single pot dehydrogenation of methanol and hydrogenation of the model compound dihydrobenzofuran.

A shock capturing technique for hypersonic, chemically relaxing flows

NASA Technical Reports Server (NTRS)

Eberhardt, S.; Brown, K.

1986-01-01

A fully coupled, shock capturing technique is presented for chemically reacting flows at high Mach numbers. The technique makes use of a total variation diminishing (TVD) dissipation operator which results in sharp, crisp shocks. The eigenvalues and eigenvectors of the fully coupled system, which includes species conversion equations in addition to the gas dynamics equations, are analytically derived for a general reacting gas. Species production terms for a model dissociating gas are introduced and are included in the algorithm. The convective terms are solved using a first-order TVD scheme while the source terms are solved using a fourth-order Runge-Kutta scheme to enhance stability. Results from one-dimensional numerical experiments are shown for a two species and a three species gas.

Developing a flood monitoring system from remotely sensed data for the Limpopo basin

USGS Publications Warehouse

Asante, K.O.; Macuacua, R.D.; Artan, G.A.; Lietzow, R.W.; Verdin, J.P.

2007-01-01

This paper describes the application of remotely sensed precipitation to the monitoring of floods in a region that regularly experiences extreme precipitation and flood events, often associated with cyclonic systems. Precipitation data, which are derived from spaceborne radar aboard the National Aeronautics and Space Administration's Tropical Rainfall Measuring Mission and from National Oceanic and Atmospheric Administration's infrared-based products, are used to monitor areas experiencing extreme precipitation events that are defined as exceedance of a daily mean areal average value of 50 mm over a catchment. The remotely sensed precipitation data are also ingested into a hydrologic model that is parameterized using spatially distributed elevation, soil, and land cover data sets that are available globally from remote sensing and in situ sources. The resulting stream-flow is classified as an extreme flood event when flow anomalies exceed 1.5 standard deviations above the short-term mean. In an application in the Limpopo basin, it is demonstrated that the use of satellite-derived precipitation allows for the identification of extreme precipitation and flood events, both in terms of relative intensity and spatial extent. The system is used by water authorities in Mozambique to proactively initiate independent flood hazard verification before generating flood warnings. The system also serves as a supplementary information source when in situ gauging systems are disrupted. This paper concludes that remotely sensed precipitation and derived products greatly enhance the ability of water managers in the Limpopo basin to monitor extreme flood events and provide at-risk communities with early warning information. ?? 2007 IEEE.

Fingerprinting of bed sediment in the Tay Estuary, Scotland: an environmental magnetism approach

NASA Astrophysics Data System (ADS)

Jenkins, Pierre A.; Duck, Rob W.; Rowan, John S.; Walden, John

Sediment fingerprinting is commonly used for sediment provenance studies in lakes, rivers and reservoirs and on hillslopes and floodplains. This investigation explores the mixing of terrestrial and marine-derived sediment in the Tay Estuary, Scotland, using mineral magnetic attributes for fingerprinting. Samples representative of the estuary sediments and of four sources (end-members) were subjected to a suite of magnetic susceptibility and remanence measurements. Sediment samples from the beds of the Rivers Tay and Earn represented fluvial inputs while samples from the Angus and Fife coasts represented marine input. Multivariate discriminant and factor analysis showed that the sources could be separated on the basis of six magnetic parameters in a simple multivariate unmixing model to identify source contributions to estuarine bed sediments. Multi-domain magnetite signatures, characteristic of unweathered bedrock, dominate the magnetic measurements. Overall contributions of 3% from the River Earn, 17% from the River Tay, 29% from the Angus coast and 51% from the Fife coast source end-members, demonstrated the present-day regime of marine sediment derivation in the Tay Estuary. However, this conceals considerable spatial variability both along-estuary and in terms of sub-environments, with small-scale variations in sediment provenance reflecting local morphology, particularly areas of channel convergence.

Nonlinear Conservation Laws and Finite Volume Methods

NASA Astrophysics Data System (ADS)

Leveque, Randall J.

Introduction Software Notation Classification of Differential Equations Derivation of Conservation Laws The Euler Equations of Gas Dynamics Dissipative Fluxes Source Terms Radiative Transfer and Isothermal Equations Multi-dimensional Conservation Laws The Shock Tube Problem Mathematical Theory of Hyperbolic Systems Scalar Equations Linear Hyperbolic Systems Nonlinear Systems The Riemann Problem for the Euler Equations Numerical Methods in One Dimension Finite Difference Theory Finite Volume Methods Importance of Conservation Form - Incorrect Shock Speeds Numerical Flux Functions Godunov's Method Approximate Riemann Solvers High-Resolution Methods Other Approaches Boundary Conditions Source Terms and Fractional Steps Unsplit Methods Fractional Step Methods General Formulation of Fractional Step Methods Stiff Source Terms Quasi-stationary Flow and Gravity Multi-dimensional Problems Dimensional Splitting Multi-dimensional Finite Volume Methods Grids and Adaptive Refinement Computational Difficulties Low-Density Flows Discrete Shocks and Viscous Profiles Start-Up Errors Wall Heating Slow-Moving Shocks Grid Orientation Effects Grid-Aligned Shocks Magnetohydrodynamics The MHD Equations One-Dimensional MHD Solving the Riemann Problem Nonstrict Hyperbolicity Stiffness The Divergence of B Riemann Problems in Multi-dimensional MHD Staggered Grids The 8-Wave Riemann Solver Relativistic Hydrodynamics Conservation Laws in Spacetime The Continuity Equation The 4-Momentum of a Particle The Stress-Energy Tensor Finite Volume Methods Multi-dimensional Relativistic Flow Gravitation and General Relativity References

Nonlocal effects in nonisothermal hydrodynamics from the perspective of beyond-equilibrium thermodynamics.

PubMed

Hütter, Markus; Brader, Joseph M

2009-06-07

We examine the origins of nonlocality in a nonisothermal hydrodynamic formulation of a one-component fluid of particles that exhibit long-range correlations, e.g., due to a spherically symmetric, long-range interaction potential. In order to furnish the continuum modeling with physical understanding of the microscopic interactions and dynamics, we make use of systematic coarse graining from the microscopic to the continuum level. We thus arrive at a thermodynamically admissible and closed set of evolution equations for the densities of momentum, mass, and internal energy. From the consideration of an illustrative special case, the following main conclusions emerge. There are two different source terms in the momentum balance. The first is a body force, which in special circumstances can be related to the functional derivative of a nonlocal Helmholtz free energy density with respect to the mass density. The second source term is proportional to the temperature gradient, multiplied by the nonlocal entropy density. These two source terms combine into a pressure gradient only in the absence of long-range effects. In the irreversible contributions to the time evolution, the nonlocal contributions arise since the self-correlations of the stress tensor and heat flux, respectively, are nonlocal as a result of the microscopic nonlocal correlations. Finally, we point out specific points that warrant further discussions.

A stable computation of log-derivatives from noisy drawdown data

NASA Astrophysics Data System (ADS)

Ramos, Gustavo; Carrera, Jesus; Gómez, Susana; Minutti, Carlos; Camacho, Rodolfo

2017-09-01

Pumping tests interpretation is an art that involves dealing with noise coming from multiple sources and conceptual model uncertainty. Interpretation is greatly helped by diagnostic plots, which include drawdown data and their derivative with respect to log-time, called log-derivative. Log-derivatives are especially useful to complement geological understanding in helping to identify the underlying model of fluid flow because they are sensitive to subtle variations in the response to pumping of aquifers and oil reservoirs. The main problem with their use lies in the calculation of the log-derivatives themselves, which may display fluctuations when data are noisy. To overcome this difficulty, we propose a variational regularization approach based on the minimization of a functional consisting of two terms: one ensuring that the computed log-derivatives honor measurements and one that penalizes fluctuations. The minimization leads to a diffusion-like differential equation in the log-derivatives, and boundary conditions that are appropriate for well hydraulics (i.e., radial flow, wellbore storage, fractal behavior, etc.). We have solved this equation by finite differences. We tested the methodology on two synthetic examples showing that a robust solution is obtained. We also report the resulting log-derivative for a real case.

A time-dependent neutron transport method of characteristics formulation with time derivative propagation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffman, Adam J., E-mail: adamhoff@umich.edu; Lee, John C., E-mail: jcl@umich.edu

2016-02-15

A new time-dependent Method of Characteristics (MOC) formulation for nuclear reactor kinetics was developed utilizing angular flux time-derivative propagation. This method avoids the requirement of storing the angular flux at previous points in time to represent a discretized time derivative; instead, an equation for the angular flux time derivative along 1D spatial characteristics is derived and solved concurrently with the 1D transport characteristic equation. This approach allows the angular flux time derivative to be recast principally in terms of the neutron source time derivatives, which are approximated to high-order accuracy using the backward differentiation formula (BDF). This approach, called Sourcemore » Derivative Propagation (SDP), drastically reduces the memory requirements of time-dependent MOC relative to methods that require storing the angular flux. An SDP method was developed for 2D and 3D applications and implemented in the computer code DeCART in 2D. DeCART was used to model two reactor transient benchmarks: a modified TWIGL problem and a C5G7 transient. The SDP method accurately and efficiently replicated the solution of the conventional time-dependent MOC method using two orders of magnitude less memory.« less

Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review

PubMed Central

Uzma, Fazilath; Mohan, Chakrabhavi D.; Hashem, Abeer; Konappa, Narasimha M.; Rangappa, Shobith; Kamath, Praveen V.; Singh, Bhim P.; Mudili, Venkataramana; Gupta, Vijai K.; Siddaiah, Chandra N.; Chowdappa, Srinivas; Alqarawi, Abdulaziz A.; Abd_Allah, Elsayed F.

2018-01-01

Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new and improved chemotherapeutics derived from natural or synthetic sources. Natural sources offer the potential of finding new structural classes with unique bioactivities for cancer therapy. Endophytic fungi represent a rich source of bioactive metabolites that can be manipulated to produce desirable novel analogs for chemotherapy. This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies. It also covers recent literature on endophytic fungal metabolites from terrestrial, mangrove, and marine sources as potential anticancer agents and emphasizes the findings for cytotoxic bioactive compounds tested against specific cancer cell lines. PMID:29755344

Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues.

PubMed

Tamura, Hirosumi; Higa, Arisa; Hoshi, Hirotaka; Hiyama, Gen; Takahashi, Nobuhiko; Ryufuku, Masae; Morisawa, Gaku; Yanagisawa, Yuka; Ito, Emi; Imai, Jun-Ichi; Dobashi, Yuu; Katahira, Kiyoaki; Soeda, Shu; Watanabe, Takafumi; Fujimori, Keiya; Watanabe, Shinya; Takagi, Motoki

2018-06-18

Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation, patient-derived tumor organoids (PDOs) were established from human lung, ovarian and uterine tumor tissues, among others, to accurately and efficiently recapitulate the tissue architecture and function. PDOs were able to be cultured for >6 months, and formed cell clusters with similar morphologies to their source tumors. Comparative histological and comprehensive gene expression analyses proved that the characteristics of PDOs were similar to those of their source tumors, even following long-term expansion in culture. At present, 53 PDOs have been established by the Fukushima Translational Research Project, and were designated as Fukushima PDOs (F‑PDOs). In addition, the in vivo tumorigenesis of certain F‑PDOs was confirmed using a xenograft model. The present study represents a detailed analysis of three F‑PDOs (termed REME9, 11 and 16) established from endometrial cancer tissues. These were used for cell growth inhibition experiments using anticancer agents. A suitable high-throughput assay system, with 96- or 384‑well plates, was designed for each F‑PDO, and the efficacy of the anticancer agents was subsequently evaluated. REME9 and 11 exhibited distinct responses and increased resistance to the drugs, as compared with conventional cancer cell lines (AN3 CA and RL95-2). REME9 and 11, which were established from tumors that originated in patients who did not respond to paclitaxel and carboplatin (the standard chemotherapy for endometrial cancer), exhibited high resistance (half-maximal inhibitory concentration >10 µM) to the two agents. Therefore, assay systems using F‑PDOs may be utilized to evaluate anticancer agents using conditions that better reflect clinical conditions, compared with conventional methods using cancer cell lines, and to discover markers that identify the pharmacological effects of anticancer agents.

Representing Thoughts, Words, and Things in the UMLS

PubMed Central

Campbell, Keith E.; Oliver, Diane E.; Spackman, Kent A.; Shortliffe, Edward H.

1998-01-01

The authors describe a framework, based on the Ogden-Richards semiotic triangle, for understanding the relationship between the Unified Medical Language System (UMLS) and the source terminologies from which the UMLS derives its content. They pay particular attention to UMLS's Concept Unique Identifier (CUI) and the sense of “meaning” it represents as contrasted with the sense of “meaning” represented by the source terminologies. The CUI takes on emergent meaning through linkage to terms in different terminology systems. In some cases, a CUI's emergent meaning can differ significantly from the original sources' intended meanings of terms linked by that CUI. Identification of these different senses of meaning within the UMLS is consistent with historical themes of semantic interpretation of language. Examination of the UMLS within such a historical framework makes it possible to better understand the strengths and limitations of the UMLS approach for integrating disparate terminologic systems and to provide a model, or theoretic foundation, for evaluating the UMLS as a Possible World—that is, as a mathematical formalism that represents propositions about some perspective or interpretation of the physical world. PMID:9760390

MEqTrees Telescope and Radio-sky Simulations and CPU Benchmarking

NASA Astrophysics Data System (ADS)

Shanmugha Sundaram, G. A.

2009-09-01

MEqTrees is a Python-based implementation of the classical Measurement Equation, wherein the various 2×2 Jones matrices are parametrized representations in the spatial and sky domains for any generic radio telescope. Customized simulations of radio-source sky models and corrupt Jones terms are demonstrated based on a policy framework, with performance estimates derived for array configurations, ``dirty''-map residuals and processing power requirements for such computations on conventional platforms.

Radiative Transfer in a Translucent Cloud Illuminated by an Extended Background Source

NASA Astrophysics Data System (ADS)

Biganzoli, Davide; Potenza, Marco A. C.; Robberto, Massimo

2017-05-01

We discuss the radiative transfer theory for translucent clouds illuminated by an extended background source. First, we derive a rigorous solution based on the assumption that multiple scatterings produce an isotropic flux. Then we derive a more manageable analytic approximation showing that it nicely matches the results of the rigorous approach. To validate our model, we compare our predictions with accurate laboratory measurements for various types of well-characterized grains, including purely dielectric and strongly absorbing materials representative of astronomical icy and metallic grains, respectively, finding excellent agreement without the need to add free parameters. We use our model to explore the behavior of an astrophysical cloud illuminated by a diffuse source with dust grains having parameters typical of the classic ISM grains of Draine & Lee and protoplanetary disks, with an application to the dark silhouette disk 114-426 in Orion Nebula. We find that the scattering term modifies the transmitted radiation, both in terms of intensity (extinction) and shape (reddening) of the spectral distribution. In particular, for small optical thickness, our results show that scattering makes reddening almost negligible at visible wavelengths. Once the optical thickness increases enough and the probability of scattering events becomes close to or larger than 1, reddening becomes present but is appreciably modified with respect to the standard expression for line-of-sight absorption. Moreover, variations of the grain refractive index, in particular the amount of absorption, also play an important role in changing the shape of the spectral transmission curve, with dielectric grains showing the minimum amount of reddening.

A comparative assessment of cartilage and joint fat pad as a potential source of cells for autologous therapy development in knee osteoarthritis.

PubMed

English, A; Jones, E A; Corscadden, D; Henshaw, K; Chapman, T; Emery, P; McGonagle, D

2007-11-01

The utility of autologous chondrocytes for cartilage repair strategies in older subjects with osteoarthritis (OA) may be limited by both age-related and disease-associated decline in chondrogenesis. The aim of this work was to assess OA Hoffa's fat pad as an alternative source of autologous chondroprogenitor cells and to compare it with OA chondrocytes derived from different areas of cartilage. Cartilage and fat pad tissue digests were obtained from 26 subjects with knee OA and compared with normal bone marrow (BM) mesenchymal stem cells (MSCs) with respect to their in vitro colony-forming potential, growth kinetics, multipotentiality and clonogenicity. Flow cytometry was used to investigate their MSC marker phenotype. Expanded cultures derived from eroded areas of cartilage were slightly more chondrogenic than those derived from macroscopically normal cartilage or chondro-osteophytes; however, all cartilage-derived cultures failed to maintain their chondrogenic potency following extended expansion. In contrast, OA fat pads contained highly clonogenic and multipotential cells with stable chondrogenic potency in vitro, even after 16 population doublings. Standard colony-forming assays failed to reflect the observed functional differences between the studied tissues whereas flow cytometry revealed higher levels of a putative MSC marker low-affinity growth factor receptor (LNGFR) on culture expanded fat pad-derived, but not cartilage-derived, MSCs. In contrast to OA cartilage from three different sites, OA Hoffa's fat pad contains clonogenic cells that meet the criteria for MSCs and produce multipotential cultures that maintain their chondrogenesis long term. These findings have broad implications for future strategies aimed at cartilage repair in OA.

The European Infrasound Bulletin

NASA Astrophysics Data System (ADS)

Pilger, Christoph; Ceranna, Lars; Ross, J. Ole; Vergoz, Julien; Le Pichon, Alexis; Brachet, Nicolas; Blanc, Elisabeth; Kero, Johan; Liszka, Ludwik; Gibbons, Steven; Kvaerna, Tormod; Näsholm, Sven Peter; Marchetti, Emanuele; Ripepe, Maurizio; Smets, Pieter; Evers, Laslo; Ghica, Daniela; Ionescu, Constantin; Sindelarova, Tereza; Ben Horin, Yochai; Mialle, Pierrick

2018-05-01

The European Infrasound Bulletin highlights infrasound activity produced mostly by anthropogenic sources, recorded all over Europe and collected in the course of the ARISE and ARISE2 projects (Atmospheric dynamics Research InfraStructure in Europe). Data includes high-frequency (> 0.7 Hz) infrasound detections at 24 European infrasound arrays from nine different national institutions complemented with infrasound stations of the International Monitoring System for the Comprehensive Nuclear-Test-Ban Treaty (CTBT). Data were acquired during 16 years of operation (from 2000 to 2015) and processed to identify and locate ˜ 48,000 infrasound events within Europe. The source locations of these events were derived by combining at least two corresponding station detections per event. Comparisons with ground-truth sources, e.g., Scandinavian mining activity, are provided as well as comparisons with the CTBT Late Event Bulletin (LEB). Relocation is performed using ray-tracing methods to estimate celerity and back-azimuth corrections for source location based on meteorological wind and temperature values for each event derived from European Centre for Medium-range Weather Forecast (ECMWF) data. This study focuses on the analysis of repeating, man-made infrasound events (e.g., mining blasts and supersonic flights) and on the seasonal, weekly and diurnal variation of the infrasonic activity of sources in Europe. Drawing comparisons to previous studies shows that improvements in terms of detection, association and location are made within this study due to increasing the station density and thus the number of events and determined source regions. This improves the capability of the infrasound station network in Europe to more comprehensively estimate the activity of anthropogenic infrasound sources in Europe.

Wave energy transfer in elastic half-spaces with soft interlayers.

PubMed

Glushkov, Evgeny; Glushkova, Natalia; Fomenko, Sergey

2015-04-01

The paper deals with guided waves generated by a surface load in a coated elastic half-space. The analysis is based on the explicit integral and asymptotic expressions derived in terms of Green's matrix and given loads for both laminate and functionally graded substrates. To perform the energy analysis, explicit expressions for the time-averaged amount of energy transferred in the time-harmonic wave field by every excited guided or body wave through horizontal planes and lateral cylindrical surfaces have been also derived. The study is focused on the peculiarities of wave energy transmission in substrates with soft interlayers that serve as internal channels for the excited guided waves. The notable features of the source energy partitioning in such media are the domination of a single emerging mode in each consecutive frequency subrange and the appearance of reverse energy fluxes at certain frequencies. These effects as well as modal and spatial distribution of the wave energy coming from the source into the substructure are numerically analyzed and discussed.

Indirect (source-free) integration method. I. Wave-forms from geodesic generic orbits of EMRIs

NASA Astrophysics Data System (ADS)

Ritter, Patxi; Aoudia, Sofiane; Spallicci, Alessandro D. A. M.; Cordier, Stéphane

2016-12-01

The Regge-Wheeler-Zerilli (RWZ) wave-equation describes Schwarzschild-Droste black hole perturbations. The source term contains a Dirac distribution and its derivative. We have previously designed a method of integration in time domain. It consists of a finite difference scheme where analytic expressions, dealing with the wave-function discontinuity through the jump conditions, replace the direct integration of the source and the potential. Herein, we successfully apply the same method to the geodesic generic orbits of EMRI (Extreme Mass Ratio Inspiral) sources, at second order. An EMRI is a Compact Star (CS) captured by a Super-Massive Black Hole (SMBH). These are considered the best probes for testing gravitation in strong regime. The gravitational wave-forms, the radiated energy and angular momentum at infinity are computed and extensively compared with other methods, for different orbits (circular, elliptic, parabolic, including zoom-whirl).

Flow diagram analysis of electrical fatalities in construction industry.

PubMed

Chi, Chia-Fen; Lin, Yuan-Yuan; Ikhwan, Mohamad

2012-01-01

The current study reanalyzed 250 electrical fatalities in the construction industry from 1996 to 2002 into seven patterns based on source of electricity (power line, energized equipment, improperly installed or damaged equipment), direct contact or indirect contact through some source of injury (boom vehicle, metal bar or pipe, and other conductive material). Each fatality was coded in terms of age, company size, experience, performing tasks, source of injury, accident cause and hazard pattern. The Chi-square Automatic Interaction Detector (CHAID) was applied to the coded data of the fatal electrocution to find a subset of predictors that might derive meaningful classifications or accidents scenarios. A series of Flow Diagrams was constructed based on CHAID result to illustrate the flow of electricity travelling from electrical source to human body. Each of the flow diagrams can be directly linked with feasible prevention strategies by cutting the flow of electricity.

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions.

PubMed

Fukuda, Takayuki; Takayama, Kazuo; Hirata, Mitsuhi; Liu, Yu-Jung; Yanagihara, Kana; Suga, Mika; Mizuguchi, Hiroyuki; Furue, Miho K

2017-03-15

Limited growth potential, narrow ranges of sources, and difference in variability and functions from batch to batch of primary hepatocytes cause a problem for predicting drug-induced hepatotoxicity during drug development. Human pluripotent stem cell (hPSC)-derived hepatocyte-like cells in vitro are expected as a tool for predicting drug-induced hepatotoxicity. Several studies have already reported efficient methods for differentiating hPSCs into hepatocyte-like cells, however its differentiation process is time-consuming, labor-intensive, cost-intensive, and unstable. In order to solve this problem, expansion culture for hPSC-derived hepatic progenitor cells, including hepatic stem cells and hepatoblasts which can self-renewal and differentiate into hepatocytes should be valuable as a source of hepatocytes. However, the mechanisms of the expansion of hPSC-derived hepatic progenitor cells are not yet fully understood. In this study, to isolate hPSC-derived hepatic progenitor cells, we tried to develop serum-free growth factor defined culture conditions using defined components. Our culture conditions were able to isolate and grow hPSC-derived hepatic progenitor cells which could differentiate into hepatocyte-like cells through hepatoblast-like cells. We have confirmed that the hepatocyte-like cells prepared by our methods were able to increase gene expression of cytochrome P450 enzymes upon encountering rifampicin, phenobarbital, or omeprazole. The isolation and expansion of hPSC-derived hepatic progenitor cells in defined culture conditions should have advantages in terms of detecting accurate effects of exogenous factors on hepatic lineage differentiation, understanding mechanisms underlying self-renewal ability of hepatic progenitor cells, and stably supplying functional hepatic cells. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

An Update to the NASA Reference Solar Sail Thrust Model

NASA Technical Reports Server (NTRS)

Heaton, Andrew F.; Artusio-Glimpse, Alexandra B.

2015-01-01

An optical model of solar sail material originally derived at JPL in 1978 has since served as the de facto standard for NASA and other solar sail researchers. The optical model includes terms for specular and diffuse reflection, thermal emission, and non-Lambertian diffuse reflection. The standard coefficients for these terms are based on tests of 2.5 micrometer Kapton sail material coated with 100 nm of aluminum on the front side and chromium on the back side. The original derivation of these coefficients was documented in an internal JPL technical memorandum that is no longer available. Additionally more recent optical testing has taken place and different materials have been used or are under consideration by various researchers for solar sails. Here, where possible, we re-derive the optical coefficients from the 1978 model and update them to accommodate newer test results and sail material. The source of the commonly used value for the front side non-Lambertian coefficient is not clear, so we investigate that coefficient in detail. Although this research is primarily designed to support the upcoming NASA NEA Scout and Lunar Flashlight solar sail missions, the results are also of interest to the wider solar sail community.

Selective advantage of implementing optimal contributions selection and timescales for the convergence of long-term genetic contributions.

PubMed

Howard, David M; Pong-Wong, Ricardo; Knap, Pieter W; Kremer, Valentin D; Woolliams, John A

2018-05-10

Optimal contributions selection (OCS) provides animal breeders with a framework for maximising genetic gain for a predefined rate of inbreeding. Simulation studies have indicated that the source of the selective advantage of OCS is derived from breeding decisions being more closely aligned with estimates of Mendelian sampling terms ([Formula: see text]) of selection candidates, rather than estimated breeding values (EBV). This study represents the first attempt to assess the source of the selective advantage provided by OCS using a commercial pig population and by testing three hypotheses: (1) OCS places more emphasis on [Formula: see text] compared to EBV for determining which animals were selected as parents, (2) OCS places more emphasis on [Formula: see text] compared to EBV for determining which of those parents were selected to make a long-term genetic contribution (r), and (3) OCS places more emphasis on [Formula: see text] compared to EBV for determining the magnitude of r. The population studied also provided an opportunity to investigate the convergence of r over time. Selection intensity limited the number of males available for analysis, but females provided some evidence that the selective advantage derived from applying an OCS algorithm resulted from greater weighting being placed on [Formula: see text] during the process of decision-making. Male r were found to converge initially at a faster rate than female r, with approximately 90% convergence achieved within seven generations across both sexes. This study of commercial data provides some support to results from theoretical and simulation studies that the source of selective advantage from OCS comes from [Formula: see text]. The implication that genomic selection (GS) improves estimation of [Formula: see text] should allow for even greater genetic gains for a predefined rate of inbreeding, once the synergistic benefits of combining OCS and GS are realised.

Long-Term Cultured Human Term Placenta-Derived Mesenchymal Stem Cells of Maternal Origin Displays Plasticity

PubMed Central

Sabapathy, Vikram; Ravi, Saranya; Srivastava, Vivi; Srivastava, Alok; Kumar, Sanjay

2012-01-01

Mesenchymal stem cells (MSCs) are an alluring therapeutic resource because of their plasticity, immunoregulatory capacity and ease of availability. Human BM-derived MSCs have limited proliferative capability, consequently, it is challenging to use in tissue engineering and regenerative medicine applications. Hence, placental MSCs of maternal origin, which is one of richest sources of MSCs were chosen to establish long-term culture from the cotyledons of full-term human placenta. Flow analysis established bonafied MSCs phenotypic characteristics, staining positively for CD29, CD73, CD90, CD105 and negatively for CD14, CD34, CD45 markers. Pluripotency of the cultured MSCs was assessed by in vitro differentiation towards not only intralineage cells like adipocytes, osteocytes, chondrocytes, and myotubules cells but also translineage differentiated towards pancreatic progenitor cells, neural cells, and retinal cells displaying plasticity. These cells did not significantly alter cell cycle or apoptosis pattern while maintaining the normal karyotype; they also have limited expression of MHC-II antigens and are Naive for stimulatory factors CD80 and CD 86. Further soft agar assays revealed that placental MSCs do not have the ability to form invasive colonies. Taking together all these characteristics into consideration, it indicates that placental MSCs could serve as good candidates for development and progress of stem-cell based therapeutics. PMID:22550499

Filtered Mass Density Function for Design Simulation of High Speed Airbreathing Propulsion Systems

NASA Technical Reports Server (NTRS)

Drozda, T. G.; Sheikhi, R. M.; Givi, Peyman

2001-01-01

The objective of this research is to develop and implement new methodology for large eddy simulation of (LES) of high-speed reacting turbulent flows. We have just completed two (2) years of Phase I of this research. This annual report provides a brief and up-to-date summary of our activities during the period: September 1, 2000 through August 31, 2001. In the work within the past year, a methodology termed "velocity-scalar filtered density function" (VSFDF) is developed and implemented for large eddy simulation (LES) of turbulent flows. In this methodology the effects of the unresolved subgrid scales (SGS) are taken into account by considering the joint probability density function (PDF) of all of the components of the velocity and scalar vectors. An exact transport equation is derived for the VSFDF in which the effects of the unresolved SGS convection, SGS velocity-scalar source, and SGS scalar-scalar source terms appear in closed form. The remaining unclosed terms in this equation are modeled. A system of stochastic differential equations (SDEs) which yields statistically equivalent results to the modeled VSFDF transport equation is constructed. These SDEs are solved numerically by a Lagrangian Monte Carlo procedure. The consistency of the proposed SDEs and the convergence of the Monte Carlo solution are assessed by comparison with results obtained by an Eulerian LES procedure in which the corresponding transport equations for the first two SGS moments are solved. The unclosed SGS convection, SGS velocity-scalar source, and SGS scalar-scalar source in the Eulerian LES are replaced by corresponding terms from VSFDF equation. The consistency of the results is then analyzed for a case of two dimensional mixing layer.

Nitrogen enrichment regulates calcium sources in forests

USGS Publications Warehouse

Hynicka, Justin D.; Pett-Ridge, Julie C.; Perakis, Steven

2016-01-01

Nitrogen (N) is a key nutrient that shapes cycles of other essential elements in forests, including calcium (Ca). When N availability exceeds ecosystem demands, excess N can stimulate Ca leaching and deplete Ca from soils. Over the long term, these processes may alter the proportion of available Ca that is derived from atmospheric deposition vs. bedrock weathering, which has fundamental consequences for ecosystem properties and nutrient supply. We evaluated how landscape variation in soil N, reflecting long-term legacies of biological N fixation, influenced plant and soil Ca availability and ecosystem Ca sources across 22 temperate forests in Oregon. We also examined interactions between soil N and bedrock Ca using soil N gradients on contrasting basaltic vs. sedimentary bedrock that differed 17-fold in underlying Ca content. We found that low-N forests on Ca-rich basaltic bedrock relied strongly on Ca from weathering, but that soil N enrichment depleted readily weatherable mineral Ca and shifted forest reliance toward atmospheric Ca. Forests on Ca-poor sedimentary bedrock relied more consistently on atmospheric Ca across all levels of soil N enrichment. The broad importance of atmospheric Ca was unexpected given active regional uplift and erosion that are thought to rejuvenate weathering supply of soil minerals. Despite different Ca sources to forests on basaltic vs. sedimentary bedrock, we observed consistent declines in plant and soil Ca availability with increasing N, regardless of the Ca content of underlying bedrock. Thus, traditional measures of Ca availability in foliage and soil exchangeable pools may poorly reflect long-term Ca sources that sustain soil fertility. We conclude that long-term soil N enrichment can deplete available Ca and cause forests to rely increasingly on Ca from atmospheric deposition, which may limit ecosystem Ca supply in an increasingly N-rich world.

Exact Fourier expansion in cylindrical coordinates for the three-dimensional Helmholtz Green function

NASA Astrophysics Data System (ADS)

Conway, John T.; Cohl, Howard S.

2010-06-01

A new method is presented for Fourier decomposition of the Helmholtz Green function in cylindrical coordinates, which is equivalent to obtaining the solution of the Helmholtz equation for a general ring source. The Fourier coefficients of the Green function are split into their half advanced + half retarded and half advanced-half retarded components, and closed form solutions for these components are then obtained in terms of a Horn function and a Kampé de Fériet function respectively. Series solutions for the Fourier coefficients are given in terms of associated Legendre functions, Bessel and Hankel functions and a hypergeometric function. These series are derived either from the closed form 2-dimensional hypergeometric solutions or from an integral representation, or from both. A simple closed form far-field solution for the general Fourier coefficient is derived from the Hankel series. Numerical calculations comparing different methods of calculating the Fourier coefficients are presented. Fourth order ordinary differential equations for the Fourier coefficients are also given and discussed briefly.

Long-term culture and cryopreservation does not affect the stability and functionality of human embryonic stem cell-derived hepatocyte-like cells.

PubMed

Mandal, Arundhati; Raju, Sheena; Viswanathan, Chandra

2016-02-01

Human embryonic stem cells (hESCs) are predicted to be an unlimited source of hepatocytes which can pave the way for applications such as cell replacement therapies or as a model of human development or even to predict the hepatotoxicity of drug compounds. We have optimized a 23-d differentiation protocol to generate hepatocyte-like cells (HLCs) from hESCs, obtaining a relatively pure population which expresses the major hepatic markers and is functional and mature. The stability of the HLCs in terms of hepato-specific marker expression and functionality was found to be intact even after an extended period of in vitro culture and cryopreservation. The hESC-derived HLCs have shown the capability to display sensitivity and an alteration in the level of CYP enzyme upon drug induction. This illustrates the potential of such assays in predicting the hepatotoxicity of a drug compound leading to advancement of pharmacology.

Solving transient acoustic boundary value problems with equivalent sources using a lumped parameter approach.

PubMed

Fahnline, John B

2016-12-01

An equivalent source method is developed for solving transient acoustic boundary value problems. The method assumes the boundary surface is discretized in terms of triangular or quadrilateral elements and that the solution is represented using the acoustic fields of discrete sources placed at the element centers. Also, the boundary condition is assumed to be specified for the normal component of the surface velocity as a function of time, and the source amplitudes are determined to match the known elemental volume velocity vector at a series of discrete time steps. Equations are given for marching-on-in-time schemes to solve for the source amplitudes at each time step for simple, dipole, and tripole source formulations. Several example problems are solved to illustrate the results and to validate the formulations, including problems with closed boundary surfaces where long-time numerical instabilities typically occur. A simple relationship between the simple and dipole source amplitudes in the tripole source formulation is derived so that the source radiates primarily in the direction of the outward surface normal. The tripole source formulation is shown to eliminate interior acoustic resonances and long-time numerical instabilities.

A new aerodynamic integral equation based on an acoustic formula in the time domain

NASA Technical Reports Server (NTRS)

Farassat, F.

1984-01-01

An aerodynamic integral equation for bodies moving at transonic and supersonic speeds is presented. Based on a time-dependent acoustic formula for calculating the noise emanating from the outer portion of a propeller blade travelling at high speed (the Ffowcs Williams-Hawking formulation), the loading terms and a conventional thickness source terms are retained. Two surface and three line integrals are employed to solve an equation for the loading noise. The near-field term is regularized using the collapsing sphere approach to obtain semiconvergence on the blade surface. A singular integral equation is thereby derived for the unknown surface pressure, and is amenable to numerical solutions using Galerkin or collocation methods. The technique is useful for studying the nonuniform inflow to the propeller.

Analytical solutions for sequentially coupled one-dimensional reactive transport problems Part I: Mathematical derivations

NASA Astrophysics Data System (ADS)

Srinivasan, V.; Clement, T. P.

2008-02-01

Multi-species reactive transport equations coupled through sorption and sequential first-order reactions are commonly used to model sites contaminated with radioactive wastes, chlorinated solvents and nitrogenous species. Although researchers have been attempting to solve various forms of these reactive transport equations for over 50 years, a general closed-form analytical solution to this problem is not available in the published literature. In Part I of this two-part article, we derive a closed-form analytical solution to this problem for spatially-varying initial conditions. The proposed solution procedure employs a combination of Laplace and linear transform methods to uncouple and solve the system of partial differential equations. Two distinct solutions are derived for Dirichlet and Cauchy boundary conditions each with Bateman-type source terms. We organize and present the final solutions in a common format that represents the solutions to both boundary conditions. In addition, we provide the mathematical concepts for deriving the solution within a generic framework that can be used for solving similar transport problems.

The impact of nonuniform sampling on stratospheric ozone trends derived from occultation instruments

NASA Astrophysics Data System (ADS)

Damadeo, Robert P.; Zawodny, Joseph M.; Remsberg, Ellis E.; Walker, Kaley A.

2018-01-01

This paper applies a recently developed technique for deriving long-term trends in ozone from sparsely sampled data sets to multiple occultation instruments simultaneously without the need for homogenization. The technique can compensate for the nonuniform temporal, spatial, and diurnal sampling of the different instruments and can also be used to account for biases and drifts between instruments. These problems have been noted in recent international assessments as being a primary source of uncertainty that clouds the significance of derived trends. Results show potential recovery trends of ˜ 2-3 % decade-1 in the upper stratosphere at midlatitudes, which are similar to other studies, and also how sampling biases present in these data sets can create differences in derived recovery trends of up to ˜ 1 % decade-1 if not properly accounted for. Limitations inherent to all techniques (e.g., relative instrument drifts) and their impacts (e.g., trend differences up to ˜ 2 % decade-1) are also described and a potential path forward towards resolution is presented.

Production, Characterization and Biocompatibility of Marine Collagen Matrices from an Alternative and Sustainable Source: The Sea Urchin Paracentrotus lividus

PubMed Central

Di Benedetto, Cristiano; Barbaglio, Alice; Martinello, Tiziana; Alongi, Valentina; Fassini, Dario; Cullorà, Emanuele; Patruno, Marco; Bonasoro, Francesco; Barbosa, Mario Adolfo; Candia Carnevali, Maria Daniela; Sugni, Michela

2014-01-01

Collagen has become a key-molecule in cell culture studies and in the tissue engineering field. Industrially, the principal sources of collagen are calf skin and bones which, however, could be associated to risks of serious disease transmission. In fact, collagen derived from alternative and riskless sources is required, and marine organisms are among the safest and recently exploited ones. Sea urchins possess a circular area of soft tissue surrounding the mouth, the peristomial membrane (PM), mainly composed by mammalian-like collagen. The PM of the edible sea urchin Paracentrotus lividus therefore represents a potential unexploited collagen source, easily obtainable as a food industry waste product. Our results demonstrate that it is possible to extract native collagen fibrils from the PM and produce suitable substrates for in vitro system. The obtained matrices appear as a homogeneous fibrillar network (mean fibril diameter 30–400 nm and mesh < 2 μm) and display remarkable mechanical properties in term of stiffness (146 ± 48 MPa) and viscosity (60.98 ± 52.07 GPa·s). In vitro tests with horse pbMSC show a good biocompatibility in terms of overall cell growth. The obtained results indicate that the sea urchin P. lividus can be a valuable low-cost collagen source for mechanically resistant biomedical devices. PMID:25255130

Physical setting and natural sources of exposure to carcinogenic trace elements and radionuclides in Lahontan Valley, Nevada

USGS Publications Warehouse

Seiler, Ralph L.

2012-01-01

In Lahontan Valley, Nevada, arsenic, cobalt, tungsten, uranium, radon, and polonium-210 are carcinogens that occur naturally in sediments and groundwater. Arsenic and cobalt are principally derived from erosion of volcanic rocks in the local mountains and tungsten and uranium are derived from erosion of granitic rocks in headwater reaches of the Carson River. Radon and 210Po originate from radioactive decay of uranium in the sediments. Arsenic, aluminum, cobalt, iron, and manganese concentrations in household dust suggest it is derived from the local soils. Excess zinc and chromium in the dust are probably derived from the vacuum cleaner used to collect the dust, or household sources such as the furnace. Some samples have more than 5 times more cobalt in the dust than in the local soil, but whether the source of the excess cobalt is anthropogenic or natural cannot be determined with the available data. Cobalt concentrations are low in groundwater, but arsenic, uranium, radon, and 210Po concentrations often exceed human-health standards, and sometime greatly exceed them. Exposure to radon and its decay products in drinking water can vary significantly depending on when during the day that the water is consumed. Although the data suggests there have been no long term changes in groundwater chemistry that corresponds to the Lahontan Valley leukemia cluster, the occurrence of the very unusual leukemia cluster in an area with numerous 210Po and arsenic contaminated wells is striking, particularly in conjunction with the exceptionally high levels of urinary tungsten in Lahontan Valley residents. Additional research is needed on potential exposure pathways involving food or inhalation, and on synergistic effects of mixtures of these natural contaminants on susceptibility to development of leukemia.

Physical setting and natural sources of exposure to carcinogenic trace elements and radionuclides in Lahontan Valley, Nevada.

PubMed

Seiler, Ralph

2012-04-05

In Lahontan Valley, Nevada, arsenic, cobalt, tungsten, uranium, radon, and polonium-210 are carcinogens that occur naturally in sediments and groundwater. Arsenic and cobalt are principally derived from erosion of volcanic rocks in the local mountains and tungsten and uranium are derived from erosion of granitic rocks in headwater reaches of the Carson River. Radon and 210Po originate from radioactive decay of uranium in the sediments. Arsenic, aluminum, cobalt, iron, and manganese concentrations in household dust suggest it is derived from the local soils. Excess zinc and chromium in the dust are probably derived from the vacuum cleaner used to collect the dust, or household sources such as the furnace. Some samples have more than 5 times more cobalt in the dust than in the local soil, but whether the source of the excess cobalt is anthropogenic or natural cannot be determined with the available data. Cobalt concentrations are low in groundwater, but arsenic, uranium, radon, and 210Po concentrations often exceed human-health standards, and sometime greatly exceed them. Exposure to radon and its decay products in drinking water can vary significantly depending on when during the day that the water is consumed. Although the data suggests there have been no long term changes in groundwater chemistry that corresponds to the Lahontan Valley leukemia cluster, the occurrence of the very unusual leukemia cluster in an area with numerous 210Po and arsenic contaminated wells is striking, particularly in conjunction with the exceptionally high levels of urinary tungsten in Lahontan Valley residents. Additional research is needed on potential exposure pathways involving food or inhalation, and on synergistic effects of mixtures of these natural contaminants on susceptibility to development of leukemia. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

A hybrid probabilistic/spectral model of scalar mixing

NASA Astrophysics Data System (ADS)

Vaithianathan, T.; Collins, Lance

2002-11-01

In the probability density function (PDF) description of a turbulent reacting flow, the local temperature and species concentration are replaced by a high-dimensional joint probability that describes the distribution of states in the fluid. The PDF has the great advantage of rendering the chemical reaction source terms closed, independent of their complexity. However, molecular mixing, which involves two-point information, must be modeled. Indeed, the qualitative shape of the PDF is sensitive to this modeling, hence the reliability of the model to predict even the closed chemical source terms rests heavily on the mixing model. We will present a new closure to the mixing based on a spectral representation of the scalar field. The model is implemented as an ensemble of stochastic particles, each carrying scalar concentrations at different wavenumbers. Scalar exchanges within a given particle represent ``transfer'' while scalar exchanges between particles represent ``mixing.'' The equations governing the scalar concentrations at each wavenumber are derived from the eddy damped quasi-normal Markovian (or EDQNM) theory. The model correctly predicts the evolution of an initial double delta function PDF into a Gaussian as seen in the numerical study by Eswaran & Pope (1988). Furthermore, the model predicts the scalar gradient distribution (which is available in this representation) approaches log normal at long times. Comparisons of the model with data derived from direct numerical simulations will be shown.

Plutonium isotopes and 241Am in the atmosphere of Lithuania: A comparison of different source terms

NASA Astrophysics Data System (ADS)

Lujanienė, G.; Valiulis, D.; Byčenkienė, S.; Šakalys, J.; Povinec, P. P.

2012-12-01

137Cs, 241Am and Pu isotopes collected in aerosol samples during 1994-2011 were analyzed with special emphasis on better understanding of Pu and Am behavior in the atmosphere. The results from long-term measurements of 240Pu/239Pu atom ratios showed a bimodal frequency distribution with median values of 0.195 and 0.253, indicating two main sources contributing to the Pu activities at the Vilnius sampling station. The low Pu atom ratio of 0.141 could be attributed to the weapon-grade plutonium derived from the nuclear weapon test sites. The frequency of air masses arriving from the North-West and North-East correlated with the Pu atom ratio indicating the input from the sources located in these regions (the Novaya Zemlya test site, Siberian nuclear plants), while no correlation with the Chernobyl region was observed. Measurements carried out during the Fukushima accident showed a negligible impact of this source with Pu activities by four orders of magnitude lower as compared to the Chernobyl accident. The activity concentration of actinides measured in the integrated sample collected in March-April, 2011 showed a small contribution of Pu with unusual activity and atom ratios indicating the presence of the spent fuel of different origin than that of the Chernobyl accident.

Integration of Satellite-Derived Cloud Phase, Cloud Top Height, and Liquid Water Path into an Operational Aircraft Icing Nowcasting System

NASA Technical Reports Server (NTRS)

Haggerty, Julie; McDonough, Frank; Black, Jennifer; Landott, Scott; Wolff, Cory; Mueller, Steven; Minnis, Patrick; Smith, William, Jr.

2008-01-01

Operational products used by the U.S. Federal Aviation Administration to alert pilots of hazardous icing provide nowcast and short-term forecast estimates of the potential for the presence of supercooled liquid water and supercooled large droplets. The Current Icing Product (CIP) system employs basic satellite-derived information, including a cloud mask and cloud top temperature estimates, together with multiple other data sources to produce a gridded, three-dimensional, hourly depiction of icing probability and severity. Advanced satellite-derived cloud products developed at the NASA Langley Research Center (LaRC) provide a more detailed description of cloud properties (primarily at cloud top) compared to the basic satellite-derived information used currently in CIP. Cloud hydrometeor phase, liquid water path, cloud effective temperature, and cloud top height as estimated by the LaRC algorithms are into the CIP fuzzy logic scheme and a confidence value is determined. Examples of CIP products before and after the integration of the LaRC satellite-derived products will be presented at the conference.

Automorphic properties of low energy string amplitudes in various dimensions

NASA Astrophysics Data System (ADS)

Green, Michael B.; Russo, Jorge G.; Vanhove, Pierre

2010-04-01

This paper explores the moduli-dependent coefficients of higher-derivative interactions that appear in the low-energy expansion of the four-supergraviton amplitude of maximally supersymmetric string theory compactified on a d torus. These automorphic functions are determined for terms up to order ∂6R4 and various values of d by imposing a variety of consistency conditions. They satisfy Laplace eigenvalue equations with or without source terms, whose solutions are given in terms of Eisenstein series, or more general automorphic functions, for certain parabolic subgroups of the relevant U-duality groups. The ultraviolet divergences of the corresponding supergravity field theory limits are encoded in various logarithms, although the string theory expressions are finite. This analysis includes intriguing representations of SL(d) and SO(d,d) Eisenstein series in terms of toroidally compactified one and two-loop string and supergravity amplitudes.

On the gravitational potential and field anomalies due to thin mass layers

NASA Technical Reports Server (NTRS)

Ockendon, J. R.; Turcotte, D. L.

1977-01-01

The gravitational potential and field anomalies for thin mass layers are derived using the technique of matched asymptotic expansions. An inner solution is obtained using an expansion in powers of the thickness and it is shown that the outer solution is given by a surface distribution of mass sources and dipoles. Coefficients are evaluated by matching the inner expansion of the outer solution with the outer expansion of the inner solution. The leading term in the inner expansion for the normal gravitational field gives the Bouguer formula. The leading term in the expansion for the gravitational potential gives an expression for the perturbation to the geoid. The predictions given by this term are compared with measurements by satellite altimetry. The second-order terms in the expansion for the gravitational field are required to predict the gravity anomaly at a continental margin. The results are compared with observations.

Acoustic constituents of prosodic typology

NASA Astrophysics Data System (ADS)

Komatsu, Masahiko

Different languages sound different, and considerable part of it derives from the typological difference of prosody. Although such difference is often referred to as lexical accent types (stress accent, pitch accent, and tone; e.g. English, Japanese, and Chinese respectively) and rhythm types (stress-, syllable-, and mora-timed rhythms; e.g. English, Spanish, and Japanese respectively), it is unclear whether these types are determined in terms of acoustic properties, The thesis intends to provide a potential basis for the description of prosody in terms of acoustics. It argues for the hypothesis that the source component of the source-filter model (acoustic features) approximately corresponds to prosody (linguistic features) through several experimental-phonetic studies. The study consists of four parts. (1) Preliminary experiment: Perceptual language identification tests were performed using English and Japanese speech samples whose frequency spectral information (i.e. non-source component) is heavily reduced. The results indicated that humans can discriminate languages with such signals. (2) Discussion on the linguistic information that the source component contains: This part constitutes the foundation of the argument of the thesis. Perception tests of consonants with the source signal indicated that the source component carries the information on broad categories of phonemes that contributes to the creation of rhythm. (3) Acoustic analysis: The speech samples of Chinese, English, Japanese, and Spanish, differing in prosodic types, were analyzed. These languages showed difference in acoustic characteristics of the source component. (4) Perceptual experiment: A language identification test for the above four languages was performed using the source signal with its acoustic features parameterized. It revealed that humans can discriminate prosodic types solely with the source features and that the discrimination is easier as acoustic information increases. The series of studies showed the correspondence of the source component to prosodic features. In linguistics, prosodic types have not been discussed purely in terms of acoustics; they are usually related to the function of prosody or phonological units such as phonemes. The present thesis focuses on acoustics and makes a contribution to establishing the crosslinguistic description system of prosody.

Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation.

PubMed

Zhang, W; Kong, C W; Tong, M H; Chooi, W H; Huang, N; Li, R A; Chan, B P

2017-02-01

Cardiomyocytes derived from human embryonic stem cells (hESC-CMs) are regarded as a promising source for regenerative medicine, drug testing and disease modeling. Nevertheless, cardiomyocytes are immature in terms of their contractile structure, metabolism and electrophysiological properties. Here, we fabricate cardiac muscle strips by encapsulating hESC-CMs in collagen-based biomaterials. Supplementation of niche cells at 3% to the number of hESC-CMs enhance the maturation of the hESC-CMs in 3D tissue matrix. The benefits of adding mesenchymal stem cells (MSCs) are comparable to that of adding fibroblasts. These two cell types demonstrate similar effects in promoting the compaction and cell spreading, as well as expression of maturation markers at both gene and protein levels. Mechanical loading, particularly cyclic stretch, produces engineered cardiac tissues with higher maturity in terms of twitch force, elastic modulus, sarcomere length and molecular signature, when comparing to static stretch or non-stretched controls. The current study demonstrates that the application of niche cells and mechanical stretch both stimulate the maturation of hESC-CMs in 3D architecture. Our results therefore suggest that this 3D model can be used for in vitro cardiac maturation study. Cardiomyocytes derived from human embryonic stem cells (hESC-CMs) are regarded as being a promising source of cells for regenerative medicine, drug testing and disease modeling. Nevertheless, cardiomyocytes are immature in terms of their contractile structure, metabolism and electrophysiological properties. In the current study, we have fabricated cardiac muscle strips by encapsulating hESC-CMs in collagen-based biomaterials and demonstrated that supplementation of mesenchymal niche cells as well as provision of mechanical loading particularly stretching have significantly promoted the maturation of the cardiomyocytes and hence improved the mechanical functional characteristics of the tissue strips. Specifically, with 3% niche cells including both fibroblasts and mesenchymal stem cells, a more mature hESC-CMs derived cardiac strip was resulted, in terms of compaction and spreading of cells, and upregulation of molecular signature in both gene and protein expression of maturation. Mechanical loading, particularly cyclic stretch, produces engineered cardiac tissues with higher maturity in terms of molecular signature markers and functional parameters including twitch force, elastic modulus and sarcomere length, when comparing with static stretch or non-stretched controls. The current study demonstrates that the application of niche cells and mechanical stretch both stimulate the maturation of hESC-CMs in 3D architecture, resulting in more mature cardiac strips. Our results contribute to bioengineering of functional heart tissue strips for drug screening and disease modeling. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Using Satellite Observations to Evaluate the AeroCOM Volcanic Emissions Inventory and the Dispersal of Volcanic SO2 Clouds in MERRA

NASA Technical Reports Server (NTRS)

Hughes, Eric J.; Krotkov, Nickolay; da Silva, Arlindo; Colarco, Peter

2015-01-01

Simulation of volcanic emissions in climate models requires information that describes the eruption of the emissions into the atmosphere. While the total amount of gases and aerosols released from a volcanic eruption can be readily estimated from satellite observations, information about the source parameters, like injection altitude, eruption time and duration, is often not directly known. The AeroCOM volcanic emissions inventory provides estimates of eruption source parameters and has been used to initialize volcanic emissions in reanalysis projects, like MERRA. The AeroCOM volcanic emission inventory provides an eruptions daily SO2 flux and plume top altitude, yet an eruption can be very short lived, lasting only a few hours, and emit clouds at multiple altitudes. Case studies comparing the satellite observed dispersal of volcanic SO2 clouds to simulations in MERRA have shown mixed results. Some cases show good agreement with observations Okmok (2008), while for other eruptions the observed initial SO2 mass is half of that in the simulations, Sierra Negra (2005). In other cases, the initial SO2 amount agrees with the observations but shows very different dispersal rates, Soufriere Hills (2006). In the aviation hazards community, deriving accurate source terms is crucial for monitoring and short-term forecasting (24-h) of volcanic clouds. Back trajectory methods have been developed which use satellite observations and transport models to estimate the injection altitude, eruption time, and eruption duration of observed volcanic clouds. These methods can provide eruption timing estimates on a 2-hour temporal resolution and estimate the altitude and depth of a volcanic cloud. To better understand the differences between MERRA simulations and volcanic SO2 observations, back trajectory methods are used to estimate the source term parameters for a few volcanic eruptions and compared to their corresponding entry in the AeroCOM volcanic emission inventory. The nature of these mixed results is discussed with respect to the source term estimates.

Emission of Sound from Turbulence Convected by a Parallel Mean Flow in the Presence of a Confining Duct

NASA Technical Reports Server (NTRS)

Goldstein, Marvin E.; Leib, Stewart J.

1999-01-01

An approximate method for calculating the noise generated by a turbulent flow within a semi-infinite duct of arbitrary cross section is developed. It is based on a previously derived high-frequency solution to Lilley's equation, which describes the sound propagation in a transversely-sheared mean flow. The source term is simplified by assuming the turbulence to be axisymmetric about the mean flow direction. Numerical results are presented for the special case of a ring source in a circular duct with an axisymmetric mean flow. They show that the internally generated noise is suppressed at sufficiently large upstream angles in a hard walled duct, and that acoustic liners can significantly reduce the sound radiated in both the upstream and downstream regions, depending upon the source location and Mach number of the flow.

Emission of Sound From Turbulence Convected by a Parallel Mean Flow in the Presence of a Confining Duct

NASA Technical Reports Server (NTRS)

Goldstein, Marvin E.; Leib, Stewart J.

1999-01-01

An approximate method for calculating the noise generated by a turbulent flow within a semi-infinite duct of arbitrary cross section is developed. It is based on a previously derived high-frequency solution to Lilley's equation, which describes the sound propagation in transversely-sheared mean flow. The source term is simplified by assuming the turbulence to be axisymmetric about the mean flow direction. Numerical results are presented for the special case of a ring source in a circular duct with an axisymmetric mean flow. They show that the internally generated noise is suppressed at sufficiently large upstream angles in a hard walled duct, and that acoustic liners can significantly reduce the sound radiated in both the upstream and downstream regions, depending upon the source location and Mach number of the flow.

Exact relations for energy transfer in self-gravitating isothermal turbulence

NASA Astrophysics Data System (ADS)

Banerjee, Supratik; Kritsuk, Alexei G.

2017-11-01

Self-gravitating isothermal supersonic turbulence is analyzed in the asymptotic limit of large Reynolds numbers. Based on the inviscid invariance of total energy, an exact relation is derived for homogeneous (not necessarily isotropic) turbulence. A modified definition for the two-point energy correlation functions is used to comply with the requirement of detailed energy equipartition in the acoustic limit. In contrast to the previous relations (S. Galtier and S. Banerjee, Phys. Rev. Lett. 107, 134501 (2011), 10.1103/PhysRevLett.107.134501; S. Banerjee and S. Galtier, Phys. Rev. E 87, 013019 (2013), 10.1103/PhysRevE.87.013019), the current exact relation shows that the pressure dilatation terms play practically no role in the energy cascade. Both the flux and source terms are written in terms of two-point differences. Sources enter the relation in a form of mixed second-order structure functions. Unlike the kinetic and thermodynamic potential energies, the gravitational contribution is absent from the flux term. An estimate shows that, for the isotropic case, the correlation between density and gravitational acceleration may play an important role in modifying the energy transfer in self-gravitating turbulence. The exact relation is also written in an alternative form in terms of two-point correlation functions, which is then used to describe scale-by-scale energy budget in spectral space.

SPECTRAL SURVEY OF X-RAY BRIGHT ACTIVE GALACTIC NUCLEI FROM THE ROSSI X-RAY TIMING EXPLORER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rivers, Elizabeth; Markowitz, Alex; Rothschild, Richard, E-mail: erivers@ucsd.edu

2011-03-15

Using long-term monitoring data from the Rossi X-ray Timing Explorer (RXTE), we have selected 23 active galactic nuclei (AGNs) with sufficient brightness and overall observation time to derive broadband X-ray spectra from 3 to {approx}>100 keV. Our sample includes mainly radio-quiet Seyferts, as well as seven radio-loud sources. Given the longevity of the RXTE mission, the greater part of our data is spread out over more than a decade, providing truly long-term average spectra and eliminating inconsistencies arising from variability. We present long-term average values of absorption, Fe line parameters, Compton reflection strengths, and photon indices, as well as fluxesmore » and luminosities for the hard and very hard energy bands, 2-10 keV and 20-100 keV, respectively. We find tentative evidence for high-energy rollovers in three of our objects. We improve upon previous surveys of the very hard X-ray energy band in terms of accuracy and sensitivity, particularly with respect to confirming and quantifying the Compton reflection component. This survey is meant to provide a baseline for future analysis with respect to the long-term averages for these sources and to cement the legacy of RXTE, and especially its High Energy X-ray Timing Experiment, as a contributor to AGN spectral science.« less

Providing long term care for sex offenders: liabilities and responsibilities.

PubMed

Corson, Tyler Rogers; Nadash, Pamela

2013-11-01

The high risk for recidivism among sex offenders who need long term care (LTC) raises serious issues when they are cared for alongside frail, vulnerable adults. LTC providers must balance offenders' right to access care with other residents' right to be free from abuse and must assess and manage the risks associated with admitting offenders. This article identifies sources of legal liability that derive from sex offender management and discusses the need for the LTC community to develop reasonable, balanced guidance on how best to mitigate the risks associated with sex offenders, protect the rights of all residents, and reduce provider liabilities. Copyright © 2013 American Medical Directors Association, Inc. Published by Elsevier Inc. All rights reserved.

Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair.

PubMed

Erwin, W Mark; Islam, Diana; Eftekarpour, Eftekhar; Inman, Robert D; Karim, Muhammad Zia; Fehlings, Michael G

2013-02-01

An in vitro and in vivo evaluation of intervertebral disc (IVD)-derived stem/progenitor cells. To determine the chondrogenic, adipogenic, osteogenic, and neurogenic differentiation capacity of disc-derived stem/progenitor cells in vitro and neurogenic differentiation in vivo. Tissue repair strategies require a source of appropriate cells that could be used to replace dead or damaged cells and tissues such as stem cells. Here we examined the potential use of IVD-derived stem cells in regenerative medicine approaches and neural repair. Nonchondrodystrophic canine IVD nucleus pulposus (NP) cells were used to generate stem/progenitor cells (NP progenitor cells [NPPCs]) and the NPPCs were differentiated in vitro into chondrogenic, adipogenic, and neurogenic lineages and in vivo into the neurogenic lineage. NPPCs were compared with bone marrow-derived mesenchymal (stromal) stem cells in terms of the expression of stemness genes. The expression of the neural crest marker protein 0 and the Brachyury gene were evaluated in NP cells and NPPCs. NPPCs contain stem/progenitor cells and express "stemness" genes such as Sox2, Oct3/4, Nanog, CD133, Nestin, and neural cell adhesion molecule but differ from mesenchymal (stromal) stem cells in the higher expression of the Nanog gene by NPPCs. NPPCs do not express protein 0 or the Brachyury gene both of which are expressed by the totality of IVD NP cells. The percentage of NPPCs within the IVD is 1% of the total as derived by colony-forming assay. NPPCs are capable of differentiating along chondrogenic, adipogenic, and neurogenic lineages in vitro and into oligodendrocyte, neuron, and astroglial specific precursor cells in vivo within the compact myelin-deficient shiverer mouse. We propose that the IVD NP represents a regenerative niche suggesting that the IVD could represent a readily accessible source of precursor cells for neural repair and regeneration.

Effects of volcano topography on seismic broad-band waveforms

NASA Astrophysics Data System (ADS)

Neuberg, Jürgen; Pointer, Tim

2000-10-01

Volcano seismology often deals with rather shallow seismic sources and seismic stations deployed in their near field. The complex stratigraphy on volcanoes and near-field source effects have a strong impact on the seismic wavefield, complicating the interpretation techniques that are usually employed in earthquake seismology. In addition, as most volcanoes have a pronounced topography, the interference of the seismic wavefield with the stress-free surface results in severe waveform perturbations that affect seismic interpretation methods. In this study we deal predominantly with the surface effects, but take into account the impact of a typical volcano stratigraphy as well as near-field source effects. We derive a correction term for plane seismic waves and a plane-free surface such that for smooth topographies the effect of the free surface can be totally removed. Seismo-volcanic sources radiate energy in a broad frequency range with a correspondingly wide range of different Fresnel zones. A 2-D boundary element method is employed to study how the size of the Fresnel zone is dependent on source depth, dominant wavelength and topography in order to estimate the limits of the plane wave approximation. This approximation remains valid if the dominant wavelength does not exceed twice the source depth. Further aspects of this study concern particle motion analysis to locate point sources and the influence of the stratigraphy on particle motions. Furthermore, the deployment strategy of seismic instruments on volcanoes, as well as the direct interpretation of the broad-band waveforms in terms of pressure fluctuations in the volcanic plumbing system, are discussed.

Prevalence of microbiological contaminants in groundwater sources and risk factor assessment in Juba, South Sudan.

PubMed

Engström, Emma; Balfors, Berit; Mörtberg, Ulla; Thunvik, Roger; Gaily, Tarig; Mangold, Mikael

2015-05-15

In low-income regions, drinking water is often derived from groundwater sources, which might spread diarrheal disease if they are microbiologically polluted. This study aimed to investigate the occurrence of fecal contamination in 147 improved groundwater sources in Juba, South Sudan and to assess potential contributing risk factors, based on bivariate statistical analysis. Thermotolerant coliforms (TTCs) were detected in 66% of the investigated sources, including 95 boreholes, breaching the health-based recommendations for drinking water. A significant association (p<0.05) was determined between the presence of TTCs and the depth of cumulative, long-term prior precipitation (both within the previous five days and within the past month). No such link was found to short-term rainfall, the presence of latrines or damages in the borehole apron. However, the risk factor analysis further suggested, to a lesser degree, that the local topography and on-site hygiene were additionally significant. In summary, the analysis indicated that an important contamination mechanism was fecal pollution of the contributing groundwater, which was unlikely due to the presence of latrines; instead, infiltration from contaminated surface water was more probable. The reduction in fecal sources in the environment in Juba is thus recommended, for example, through constructing latrines or designating protection areas near water sources. The study results contribute to the understanding of microbiological contamination of groundwater sources in areas with low incomes and high population densities, tropical climates and weathered basement complex environments, which are common in urban sub-Saharan Africa. Copyright © 2015 Elsevier B.V. All rights reserved.

Weighted interior penalty discretization of fully nonlinear and weakly dispersive free surface shallow water flows

NASA Astrophysics Data System (ADS)

Di Pietro, Daniele A.; Marche, Fabien

2018-02-01

In this paper, we further investigate the use of a fully discontinuous Finite Element discrete formulation for the study of shallow water free surface flows in the fully nonlinear and weakly dispersive flow regime. We consider a decoupling strategy in which we approximate the solutions of the classical shallow water equations supplemented with a source term globally accounting for the non-hydrostatic effects. This source term can be computed through the resolution of elliptic second-order linear sub-problems, which only involve second order partial derivatives in space. We then introduce an associated Symmetric Weighted Internal Penalty discrete bilinear form, allowing to deal with the discontinuous nature of the elliptic problem's coefficients in a stable and consistent way. Similar discrete formulations are also introduced for several recent optimized fully nonlinear and weakly dispersive models. These formulations are validated again several benchmarks involving h-convergence, p-convergence and comparisons with experimental data, showing optimal convergence properties.

Source apportionment of lead in the blood of women of reproductive age living near tailings in Taxco, Guerrero, Mexico: An isotopic study.

PubMed

Vázquez Bahéna, Analine Berenice; Talavera Mendoza, Oscar; Moreno Godínez, Ma Elena; Salgado Souto, Sergio Adrián; Ruiz, Joaquín; Huerta Beristain, Gerardo

2017-04-01

The concentration and isotopic composition of lead in the blood of forty seven women of reproductive age (15-45y) exposed to multiple sources in two rural communities of the mining region of Taxco, Guerrero in southern Mexico were determined in order to identify specific contributing sources and their apportionment and to trace probable ingestion pathways. Our data indicate that >36% of the studied women have blood lead concentrations above 10μgdL -1 and up to 87% above 5μgdL -1 . Tailings contain between 2128 and 5988mgkg -1 of lead and represent the most conspicuous source in the area. Lead contents in indoor dust are largely variable (21.7-987mgkg -1 ) but only 15% of samples are above the Mexican Regulatory Guideline for urban soils (400mgkg -1 ). By contrast, 85% of glazed containers (range: 0.026-68.6mgkg -1 ) used for cooking and food storage are above the maximum 2mgL -1 of soluble lead established in the Mexican Guideline. The isotopic composition indicates that lead in the blood of 95% of the studied women can be modeled in terms of a mixing system between local ores (and derivatives), glazed pottery and Morelos bedrock, end-members, with the two former being largely the most important contributors. Only one sample shows influence of indoor paints. Indoor dust is dominated by ores and derivatives but some samples show evidence of contribution from a less radiogenic source very likely represented by interior paints. This study supports the application of lead isotopic ratios to identify potential sources and their apportionment in humans exposed to multiple sources of lead from both, natural and anthropogenic origin. Copyright © 2017 Elsevier B.V. All rights reserved.

Empirical calibration of the near-infrared Ca II triplet - III. Fitting functions

NASA Astrophysics Data System (ADS)

Cenarro, A. J.; Gorgas, J.; Cardiel, N.; Vazdekis, A.; Peletier, R. F.

2002-02-01

Using a near-infrared stellar library of 706 stars with a wide coverage of atmospheric parameters, we study the behaviour of the CaII triplet strength in terms of effective temperature, surface gravity and metallicity. Empirical fitting functions for recently defined line-strength indices, namely CaT*, CaT and PaT, are provided. These functions can be easily implemented into stellar population models to provide accurate predictions for integrated CaII strengths. We also present a thorough study of the various error sources and their relation to the residuals of the derived fitting functions. Finally, the derived functional forms and the behaviour of the predicted CaII are compared with those of previous works in the field.

An alternative approach to probabilistic seismic hazard analysis in the Aegean region using Monte Carlo simulation

NASA Astrophysics Data System (ADS)

Weatherill, Graeme; Burton, Paul W.

2010-09-01

The Aegean is the most seismically active and tectonically complex region in Europe. Damaging earthquakes have occurred here throughout recorded history, often resulting in considerable loss of life. The Monte Carlo method of probabilistic seismic hazard analysis (PSHA) is used to determine the level of ground motion likely to be exceeded in a given time period. Multiple random simulations of seismicity are generated to calculate, directly, the ground motion for a given site. Within the seismic hazard analysis we explore the impact of different seismic source models, incorporating both uniform zones and distributed seismicity. A new, simplified, seismic source model, derived from seismotectonic interpretation, is presented for the Aegean region. This is combined into the epistemic uncertainty analysis alongside existing source models for the region, and models derived by a K-means cluster analysis approach. Seismic source models derived using the K-means approach offer a degree of objectivity and reproducibility into the otherwise subjective approach of delineating seismic sources using expert judgment. Similar review and analysis is undertaken for the selection of peak ground acceleration (PGA) attenuation models, incorporating into the epistemic analysis Greek-specific models, European models and a Next Generation Attenuation model. Hazard maps for PGA on a "rock" site with a 10% probability of being exceeded in 50 years are produced and different source and attenuation models are compared. These indicate that Greek-specific attenuation models, with their smaller aleatory variability terms, produce lower PGA hazard, whilst recent European models and Next Generation Attenuation (NGA) model produce similar results. The Monte Carlo method is extended further to assimilate epistemic uncertainty into the hazard calculation, thus integrating across several appropriate source and PGA attenuation models. Site condition and fault-type are also integrated into the hazard mapping calculations. These hazard maps are in general agreement with previous maps for the Aegean, recognising the highest hazard in the Ionian Islands, Gulf of Corinth and Hellenic Arc. Peak Ground Accelerations for some sites in these regions reach as high as 500-600 cm s -2 using European/NGA attenuation models, and 400-500 cm s -2 using Greek attenuation models.

The generation of gravitational waves. I - Weak-field sources

NASA Technical Reports Server (NTRS)

Thorne, K. S.; Kovacs, S. J.

1975-01-01

This paper derives and summarizes a 'plug-in-and-grind' formalism for calculating the gravitational waves emitted by any system with weak internal gravitational fields. If the internal fields have negligible influence on the system's motions, the formalism reduces to standard 'linearized theory'. Independent of the effects of gravity on the motions, the formalism reduces to the standard 'quadrupole-moment formalism' if the motions are slow and internal stresses are weak. In the general case, the formalism expresses the radiation in terms of a retarded Green's function for slightly curved spacetime and breaks the Green's function integral into five easily understood pieces: direct radiation, produced directly by the motions of the source; whump radiation, produced by the 'gravitational stresses' of the source; transition radiation, produced by a time-changing time delay ('Shapiro effect') in the propagation of the nonradiative 1/r field of the source; focusing radiation, produced when one portion of the source focuses, in a time-dependent way, the nonradiative field of another portion of the source; and tail radiation, produced by 'back-scatter' of the nonradiative field in regions of focusing.

The generation of gravitational waves. 1. Weak-field sources: A plug-in-and-grind formalism

NASA Technical Reports Server (NTRS)

Thorne, K. S.; Kovacs, S. J.

1974-01-01

A plug-in-and-grind formalism is derived for calculating the gravitational waves emitted by any system with weak internal gravitational fields. If the internal fields have negligible influence on the system's motions, then the formalism reduces to standard linearized theory. Whether or not gravity affects the motions, if the motions are slow and internal stresses are weak, then the new formalism reduces to the standard quadrupole-moment formalism. In the general case the new formalism expresses the radiation in terms of a retarded Green's function for slightly curved spacetime, and then breaks the Green's-function integral into five easily understood pieces: direct radiation, produced directly by the motions of the sources; whump radiation, produced by the the gravitational stresses of the source; transition radiation, produced by a time-changing time delay (Shapiro effect) in the propagation of the nonradiative, 1/r field of the source; focussing radiation produced when one portion of the source focusses, in a time-dependent way, the nonradiative field of another portion of the source, and tail radiation, produced by backscatter of the nonradiative field in regions of focussing.

Performance Analysis of Physical Layer Security of Opportunistic Scheduling in Multiuser Multirelay Cooperative Networks

PubMed Central

Shim, Kyusung; Do, Nhu Tri; An, Beongku

2017-01-01

In this paper, we study the physical layer security (PLS) of opportunistic scheduling for uplink scenarios of multiuser multirelay cooperative networks. To this end, we propose a low-complexity, yet comparable secrecy performance source relay selection scheme, called the proposed source relay selection (PSRS) scheme. Specifically, the PSRS scheme first selects the least vulnerable source and then selects the relay that maximizes the system secrecy capacity for the given selected source. Additionally, the maximal ratio combining (MRC) technique and the selection combining (SC) technique are considered at the eavesdropper, respectively. Investigating the system performance in terms of secrecy outage probability (SOP), closed-form expressions of the SOP are derived. The developed analysis is corroborated through Monte Carlo simulation. Numerical results show that the PSRS scheme significantly improves the secure ability of the system compared to that of the random source relay selection scheme, but does not outperform the optimal joint source relay selection (OJSRS) scheme. However, the PSRS scheme drastically reduces the required amount of channel state information (CSI) estimations compared to that required by the OJSRS scheme, specially in dense cooperative networks. PMID:28212286

Comparisons of thermospheric density data sets and models

NASA Astrophysics Data System (ADS)

Doornbos, Eelco; van Helleputte, Tom; Emmert, John; Drob, Douglas; Bowman, Bruce R.; Pilinski, Marcin

During the past decade, continuous long-term data sets of thermospheric density have become available to researchers. These data sets have been derived from accelerometer measurements made by the CHAMP and GRACE satellites and from Space Surveillance Network (SSN) tracking data and related Two-Line Element (TLE) sets. These data have already resulted in a large number of publications on physical interpretation and improvement of empirical density modelling. This study compares four different density data sets and two empirical density models, for the period 2002-2009. These data sources are the CHAMP (1) and GRACE (2) accelerometer measurements, the long-term database of densities derived from TLE data (3), the High Accuracy Satellite Drag Model (4) run by Air Force Space Command, calibrated using SSN data, and the NRLMSISE-00 (5) and Jacchia-Bowman 2008 (6) empirical models. In describing these data sets and models, specific attention is given to differences in the geo-metrical and aerodynamic satellite modelling, applied in the conversion from drag to density measurements, which are main sources of density biases. The differences in temporal and spa-tial resolution of the density data sources are also described and taken into account. With these aspects in mind, statistics of density comparisons have been computed, both as a function of solar and geomagnetic activity levels, and as a function of latitude and local solar time. These statistics give a detailed view of the relative accuracy of the different data sets and of the biases between them. The differences are analysed with the aim at providing rough error bars on the data and models and pinpointing issues which could receive attention in future iterations of data processing algorithms and in future model development.

Preclinical Analysis of Fetal Human Mesencephalic Neural Progenitor Cell Lines: Characterization and Safety In Vitro and In Vivo

PubMed Central

Moon, Jisook; Schwarz, Sigrid C.; Lee, Hyun‐Seob; Kang, Jun Mo; Lee, Young‐Eun; Kim, Bona; Sung, Mi‐Young; Höglinger, Günter; Wegner, Florian; Kim, Jin Su; Chung, Hyung‐Min; Chang, Sung Woon; Cha, Kwang Yul; Kim, Kwang‐Soo

2016-01-01

Abstract We have developed a good manufacturing practice for long‐term cultivation of fetal human midbrain‐derived neural progenitor cells. The generation of human dopaminergic neurons may serve as a tool of either restorative cell therapies or cellular models, particularly as a reference for phenotyping region‐specific human neural stem cell lines such as human embryonic stem cells and human inducible pluripotent stem cells. We cultivated 3 different midbrain neural progenitor lines at 10, 12, and 14 weeks of gestation for more than a year and characterized them in great detail, as well as in comparison with Lund mesencephalic cells. The whole cultivation process of tissue preparation, cultivation, and cryopreservation was developed using strict serum‐free conditions and standardized operating protocols under clean‐room conditions. Long‐term‐cultivated midbrain‐derived neural progenitor cells retained stemness, midbrain fate specificity, and floorplate markers. The potential to differentiate into authentic A9‐specific dopaminergic neurons was markedly elevated after prolonged expansion, resulting in large quantities of functional dopaminergic neurons without genetic modification. In restorative cell therapeutic approaches, midbrain‐derived neural progenitor cells reversed impaired motor function in rodents, survived well, and did not exhibit tumor formation in immunodeficient nude mice in the short or long term (8 and 30 weeks, respectively). We conclude that midbrain‐derived neural progenitor cells are a promising source for human dopaminergic neurons and suitable for long‐term expansion under good manufacturing practice, thus opening the avenue for restorative clinical applications or robust cellular models such as high‐content or high‐throughput screening. Stem Cells Translational Medicine 2017;6:576–588 PMID:28191758

Assessment of groundwater exploitation in an aquifer using the random walk on grid method: a case study at Ordos, China

NASA Astrophysics Data System (ADS)

Nan, Tongchao; Li, Kaixuan; Wu, Jichun; Yin, Lihe

2018-04-01

Sustainability has been one of the key criteria of effective water exploitation. Groundwater exploitation and water-table decline at Haolebaoji water source site in the Ordos basin in NW China has drawn public attention due to concerns about potential threats to ecosystems and grazing land in the area. To better investigate the impact of production wells at Haolebaoji on the water table, an adapted algorithm called the random walk on grid method (WOG) is applied to simulate the hydraulic head in the unconfined and confined aquifers. This is the first attempt to apply WOG to a real groundwater problem. The method can not only evaluate the head values but also the contributions made by each source/sink term. One is allowed to analyze the impact of source/sink terms just as if one had an analytical solution. The head values evaluated by WOG match the values derived from the software Groundwater Modeling System (GMS). It suggests that WOG is effective and applicable in a heterogeneous aquifer with respect to practical problems, and the resultant information is useful for groundwater management.

Incorporation of dosimetry in the derivation of reference concentrations for ambient or workplace air: a conceptual approach.

PubMed

Oller, Adriana R; Oberdörster, Günter

2016-09-01

Dosimetric models are essential tools to refine inhalation risk assessments based on local respiratory effects. Dosimetric adjustments to account for differences in aerosol particle size and respiratory tract deposition and/or clearance among rodents, workers, and the general public can be applied to experimentally- and epidemiologically-determined points of departure (PODs) to calculate size-selected (e.g., PM 10 , inhalable aerosol fraction, respirable aerosol fraction) equivalent concentrations (e.g., HEC or Human Equivalent Concentration; REC or Rodent Equivalent Concentration). A modified POD (e.g., HEC) can then feed into existing frameworks for the derivation of occupational or ambient air concentration limits or reference concentrations. HECs that are expressed in terms of aerosol particle sizes experienced by humans but are derived from animal studies allow proper comparison of exposure levels and associated health effects in animals and humans. This can inform differences in responsiveness between animals and humans, based on the same deposited or retained doses and can also allow the use of both data sources in an integrated weight of evidence approach for hazard and risk assessment purposes. Whenever possible, default values should be replaced by substance-specific and target population-specific parameters. Assumptions and sources of uncertainty need to be clearly reported.

Incorporation of dosimetry in the derivation of reference concentrations for ambient or workplace air: a conceptual approach

PubMed Central

Oberdörster, Günter

2016-01-01

Dosimetric models are essential tools to refine inhalation risk assessments based on local respiratory effects. Dosimetric adjustments to account for differences in aerosol particle size and respiratory tract deposition and/or clearance among rodents, workers, and the general public can be applied to experimentally- and epidemiologically-determined points of departure (PODs) to calculate size-selected (e.g., PM10, inhalable aerosol fraction, respirable aerosol fraction) equivalent concentrations (e.g., HEC or Human Equivalent Concentration; REC or Rodent Equivalent Concentration). A modified POD (e.g., HEC) can then feed into existing frameworks for the derivation of occupational or ambient air concentration limits or reference concentrations. HECs that are expressed in terms of aerosol particle sizes experienced by humans but are derived from animal studies allow proper comparison of exposure levels and associated health effects in animals and humans. This can inform differences in responsiveness between animals and humans, based on the same deposited or retained doses and can also allow the use of both data sources in an integrated weight of evidence approach for hazard and risk assessment purposes. Whenever possible, default values should be replaced by substance-specific and target population-specific parameters. Assumptions and sources of uncertainty need to be clearly reported. PMID:27721518

Bradley Fighting Vehicle Gunnery: An Analysis of Engagement Strategies for the M242 25-mm Automatic Gun

DTIC Science & Technology

1993-03-01

source for this estimate of eight rounds per BMP target. According to analyst Donna Quirido, AMSAA does not provide or support any such estimate (30...engagement or in the case of. the Bradley, stabilization inaccuracies. According to Helgert: These errors give rise to aim-wander, a term that derives from...the same area. (6:14_5) The resulting approximation to the truncated normal integral has a maximum relative error of 0.0075. Using Polya -Williams, an

International Conference on Numerical Ship Hydrodynamics (5th) Held in Hiroshima, Japan on 24-28 September 1989

DTIC Science & Technology

1989-09-28

Introduction source. The near field part N has an integrand which is in terms of the higher order derived exponential integral func- For a number of...Methods for potential produced improved results near the flow calculations including first and stern, but none of them could accura- higher order theories ...method Naghdi method applied to the nonlinear free- in laminar boundary layer theory . I think the surface flow problems. higher theory Green-Naghdi

Mathematics and the Internet: A Source of Enormous Confusion and Great Potential

DTIC Science & Technology

2009-05-01

free Internet Myth The story recounted below of the scale-free nature of the Internet seems convincing, sound, and al- most too good to be true ...models. In fact, much of the initial excitement in the nascent field of network science can be attributed to an ear- ly and appealingly simple class...this new class of networks, com- monly referred to as scale-free networks. The term scale-free derives from the simple observation that power-law node

Coherent attacking continuous-variable quantum key distribution with entanglement in the middle

NASA Astrophysics Data System (ADS)

Zhang, Zhaoyuan; Shi, Ronghua; Zeng, Guihua; Guo, Ying

2018-06-01

We suggest an approach on the coherent attack of continuous-variable quantum key distribution (CVQKD) with an untrusted entangled source in the middle. The coherent attack strategy can be performed on the double links of quantum system, enabling the eavesdropper to steal more information from the proposed scheme using the entanglement correlation. Numeric simulation results show the improved performance of the attacked CVQKD system in terms of the derived secret key rate with the controllable parameters maximizing the stolen information.

Nutrient patterns and their food sources in an International Study Setting: report from the EPIC study.

PubMed

Moskal, Aurelie; Pisa, Pedro T; Ferrari, Pietro; Byrnes, Graham; Freisling, Heinz; Boutron-Ruault, Marie-Christine; Cadeau, Claire; Nailler, Laura; Wendt, Andrea; Kühn, Tilman; Boeing, Heiner; Buijsse, Brian; Tjønneland, Anne; Halkjær, Jytte; Dahm, Christina C; Chiuve, Stephanie E; Quirós, Jose R; Buckland, Genevieve; Molina-Montes, Esther; Amiano, Pilar; Huerta Castaño, José M; Gurrea, Aurelio Barricarte; Khaw, Kay-Tee; Lentjes, Marleen A; Key, Timothy J; Romaguera, Dora; Vergnaud, Anne-Claire; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Sacerdote, Carlotta; de Magistris, Maria Santucci; Bueno-de-Mesquita, H Bas; Ocké, Marga C; Beulens, Joline W J; Ericson, Ulrika; Drake, Isabel; Nilsson, Lena M; Winkvist, Anna; Weiderpass, Elisabete; Hjartåker, Anette; Riboli, Elio; Slimani, Nadia

2014-01-01

Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores. The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term of food sources. These outcomes open research opportunities and perspectives of using nutrient patterns in future studies particularly at international level.

Spectra of turbulently advected scalars that have small Schmidt number

NASA Astrophysics Data System (ADS)

Hill, Reginald J.

2017-09-01

Exact statistical equations are derived for turbulent advection of a passive scalar having diffusivity much larger than the kinematic viscosity, i.e., small Schmidt number. The equations contain all terms needed for precise direct numerical simulation (DNS) quantification. In the appropriate limit, the equations reduce to the classical theory for which the scalar spectrum is proportional to the energy spectrum multiplied by k-4, which, in turn, results in the inertial-diffusive range power law, k-17 /3. The classical theory was derived for the case of isotropic velocity and scalar fields. The exact equations are simplified for less restrictive cases: (1) locally isotropic scalar fluctuations at dissipation scales with no restriction on symmetry of the velocity field, (2) isotropic velocity field with averaging over all wave-vector directions with no restriction on the symmetry of the scalar, motivated by that average being used for DNS, and (3) isotropic velocity field with axisymmetric scalar fluctuations, motivated by the mean-scalar-gradient-source case. The equations are applied to recently published DNSs of passive scalars for the cases of a freely decaying scalar and a mean-scalar-gradient source. New terms in the exact equations are estimated for those cases and are found to be significant; those terms cause the deviations from the classical theory found by the DNS studies. A new formula for the mean-scalar-gradient case explains the variation of the scalar spectra for the DNS of the smallest Schmidt-number cases. Expansion in Legendre polynomials reveals the effect of axisymmetry. Inertial-diffusive-range formulas for both the zero- and second-order Legendre contributions are given. Exact statistical equations reveal what must be quantified using DNS to determine what causes deviations from asymptotic relationships.

The role of water in the petrogenesis of Marina trough magmas

NASA Astrophysics Data System (ADS)

Stolper, Edward; Newman, Sally

1994-02-01

Most variations in composition among primitive basalts from the Mariana back-arc trough can be explained by melting mixtures of an N-type mid-ocean ridge basalt (NMORB) mantle source and an H2O rich component, provided the degree of melting is positively and approximately linearly correlated with the proportion of the H2O-rich component in the mixture. We conclude that the degrees of melting by which Mariana trough magmas are generated increase from magmas similar to NMORB, through more H2O-enriched basalts, to 'arc-like' basalts, and that this increase is due to the lowering of the solidus of mantle peridotite that accompanies addition of the H2O-rich component. The H2O-rich component is likely to be ultimately derived from fluid from a subducting slab, but we propose that by the time fluids reach the source regions of Mariana trough basalts, they have interacted with sufficient mantle material that for all but the most incompatible of elements (with respect to fluid-mantle interaction), they are in equilibrium with the mantle. In contrast, fluids added to the source regions of Mariana island-arc magmas have typically interacted with less mantle and thus retain the signature of slab-derived fluids to varying degrees for all but the most compatible elements. Primitive Mariana arc basalts can be generated by melting mixtures of such incompletely exchanged slab-derived fluids and sources similar to NMORB-type mantle sources, but the degrees of melting are typically higher than those of Mariana trough NMORB and the sources have been variably depleted relative to the back-arc sources by previous melt extraction. This depletion may be related to earlier extraction of back-arc basin magmas or may evolve by repeated fluxing of the sources as fluid is continually added to them in the regions of arc magma generation. If fluid with partitioning behavior relative to the solid mantle similar to that deduced for the H2O-rich component involved in the generation of Mariana trough basalts were extracted from primitive mantle, the residual mantle would have many of the minor and trace element characteristics of typical oceanic upper mantle; primitive mantle enriched in such fluid would be a satisfactory source for the continental crust in terms of its trace and minor element chemical composition.

Mesenchymal stem cells from the Wharton's jelly of umbilical cord segments provide stromal support for the maintenance of cord blood hematopoietic stem cells during long-term ex vivo culture.

PubMed

Bakhshi, Tiki; Zabriskie, Ryan C; Bodie, Shamanique; Kidd, Shannon; Ramin, Susan; Paganessi, Laura A; Gregory, Stephanie A; Fung, Henry C; Christopherson, Kent W

2008-12-01

Hematopoietic stem cells (HSCs) are routinely obtained from marrow, mobilized peripheral blood, and umbilical cord blood. Mesenchymal stem cells (MSCs) are traditionally isolated from marrow. Bone marrow-derived MSCs (BM-MSCs) have previously demonstrated their ability to act as a feeder layer in support of ex vivo cord blood expansion. However, the use of BM-MSCs to support the growth, differentiation, and engraftment of cord blood may not be ideal for transplant purposes. Therefore, the potential of MSCs from a novel source, the Wharton's jelly of umbilical cords, to act as stromal support for the long-term culture of cord blood HSC was evaluated. Umbilical cord-derived MSCs (UC-MSCs) were cultured from the Wharton's jelly of umbilical cord segments. The UC-MSCs were then profiled for expression of 12 cell surface receptors and tested for their ability to support cord blood HSCs in a long-term culture-initiating cell (LTC-IC) assay. Upon culture, UC-MSCs express a defined set of cell surface markers (CD29, CD44, CD73, CD90, CD105, CD166, and HLA-A) and lack other markers (CD45, CD34, CD38, CD117, and HLA-DR) similar to BM-MSCs. Like BM-MSCs, UC-MSCs effectively support the growth of CD34+ cord blood cells in LTC-IC assays. These data suggest the potential therapeutic application of Wharton's jelly-derived UC-MSCs to provide stromal support structure for the long-term culture of cord blood HSCs as well as the possibility of cotransplantation of genetically identical, HLA-matched, or unmatched cord blood HSCs and UC-MSCs in the setting of HSC transplantation.

Second-order singular pertubative theory for gravitational lenses

NASA Astrophysics Data System (ADS)

Alard, C.

2018-03-01

The extension of the singular perturbative approach to the second order is presented in this paper. The general expansion to the second order is derived. The second-order expansion is considered as a small correction to the first-order expansion. Using this approach, it is demonstrated that in practice the second-order expansion is reducible to a first order expansion via a re-definition of the first-order pertubative fields. Even if in usual applications the second-order correction is small the reducibility of the second-order expansion to the first-order expansion indicates a potential degeneracy issue. In general, this degeneracy is hard to break. A useful and simple second-order approximation is the thin source approximation, which offers a direct estimation of the correction. The practical application of the corrections derived in this paper is illustrated by using an elliptical NFW lens model. The second-order pertubative expansion provides a noticeable improvement, even for the simplest case of thin source approximation. To conclude, it is clear that for accurate modelization of gravitational lenses using the perturbative method the second-order perturbative expansion should be considered. In particular, an evaluation of the degeneracy due to the second-order term should be performed, for which the thin source approximation is particularly useful.

Association between Traditional Nursing Home Quality Measures and Two Sources of Nursing Home Complaints

PubMed Central

Troyer, Jennifer L; Sause, Wendy

2013-01-01

Objective To test for an association between traditional nursing home quality measures and two sources of resident- and caregiver-derived nursing home complaints. Data Sources Nursing home complaints to the North Carolina Long-Term Care Ombudsman Program and state certification agency from October 2002 through September 2006 were matched with Online Survey Certification and Reporting data and Minimum Data Set Quality Indicators (MDS-QIs). Study Design We examine the association between the number of complaints filed against a facility and measures of inspection violations, staffing levels, and MDS-QIs. Data Extraction One observation per facility per quarter is constructed by matching quarterly data on complaints to OSCAR data from the same or most recent prior quarter and to MDS-QIs from the same quarter. One observation per inspection is obtained by matching OSCAR data to complaint totals from both the same and the immediate prior quarter. Principal Findings There is little relationship between MDS-QIs and complaints. Ombudsman complaints and inspection violations are generally unrelated, but there is a positive relationship between state certification agency complaints and inspection violations. Conclusions Ombudsman and state certification agency complaint data are resident- and caregiver-derived quality measures that are distinctive from and complement traditional quality measures. PMID:23216541

On the evolution of high-B radio pulsars with measured braking indices

NASA Astrophysics Data System (ADS)

Benli, O.; Ertan, Ü.

2017-11-01

We have investigated the long-term evolutions of the high-magnetic field radio pulsars (HBRPs) with measured braking indices in the same model that was applied earlier to individual anomalous X-ray pulsars (AXPs), soft gamma repeaters (SGRs) and dim isolated neutron stars (XDINs). We have shown that the rotational properties (period, period derivative and braking index) and the X-ray luminosity of individual HBRPs can be acquired simultaneously by the neutron stars evolving with fallback discs. The model sources reach the observed properties of HBRPs in the propeller phases, when pulsed radio emission is allowed, at ages consistent with the estimated ages of the supernova remnants of the sources. Our results indicate that the strength of magnetic dipole fields of HBRPs are comparable to and even greater than those of AXP/SGRs and XDINs, but still one or two orders of magnitude smaller than the values inferred from the magnetic dipole torque formula. The possible evolutionary paths of the sources imply that they will lose their seemingly HBRP property after about a few 104 yr, because either their rapidly decreasing period derivatives will lead them into the normal radio pulsar population or they will evolve into the accretion phase switching off the radio pulses.

Timing Studies of X Persei and the Discovery of Its Transient Quasi-periodic Oscillation Feature

NASA Technical Reports Server (NTRS)

Acuner, Z.; Inam,S. C.; Sahiner, S.; Serim, M. M.; Baykal, A.; Swank, J.

2014-01-01

We present a timing analysis of X Persei (X Per) using observations made between 1998 and 2010 with the Proportional Counter Array (PCA) onboard the Rossi X-ray Timing Explorer (RXTE) and with the INTEGRAL Soft Gamma-Ray Imager (ISGRI). All pulse arrival times obtained from the RXTE-PCA observations are phase-connected and a timing solution is obtained using these arrival times. We update the long-term pulse frequency history of the source by measuring its pulse frequencies using RXTE-PCA and ISGRI data. From the RXTEPCA data, the relation between the frequency derivative and X-ray flux suggests accretion via the companion's stellar wind. However, the detection of a transient quasi-periodic oscillation feature, peaking at approximately 0.2 Hz, suggests the existence of an accretion disc. We find that doublebreak models fit the average power spectra well, which suggests that the source has at least two different accretion flow components dominating the overall flow. From the power spectrum of frequency derivatives, we measure a power-law index of approximately - 1, which implies that, on short time-scales, disc accretion dominates over noise, while on time-scales longer than the viscous time-scales, the noise dominates. From pulse profiles, we find a correlation between the pulse fraction and the count rate of the source.

Morphology and contractile gene expression of adipose-derived mesenchymal stem cells in response to short-term cyclic uniaxial strain and TGF-β1.

PubMed

Rashidi, Neda; Tafazzoli-Shadpour, Mohammad; Haghighipour, Nooshin; Khani, Mohammad-Mehdi

2018-06-27

Previous studies have shown smooth muscle induction in adipose-derived mesenchymal stem cells (ASCs) caused by long-term cyclic stretch. Here we examined the capability of the short-term straining with time steps of 4, 8, 16 and 24 h alone or combined with TGF-β1 on smooth muscle induction of rabbit ASCs. Alterations in cell morphology were quantified through the cell shape index and orientation angle, and expression levels of α-SMA, SM22-α, h-caldesmon and calponin3 markers were examined using the real-time polymerase chain reaction (PCR) method. Moreover, F-actin cytoskeleton organization was observed by fluorescence staining. Mechanical strain either alone or combined with growth factor treatment caused significant up-regulation of both early and intermediate smooth muscle cells (SMCs) specific markers during the initial hours of stimulation peaking in 8 to 16 h. Furthermore, gradual alignment of cells perpendicular to the strain direction during loading time, and cell elongation resembling contractile SMC phenotype, together with alignment and reorganization of F-actin fibers were observed. Considering previously reported protein up-regulation in following days of straining, the effects of short-term cyclic stretch on smooth muscle induction of ASCs were revealed which can be helpful in achieving functional contractile SMCs through synergistic mechano-chemical regulation of ASCs as an appealing cell source for vascular tissue engineering.

Improved methods for the measurement and analysis of stellar magnetic fields

NASA Technical Reports Server (NTRS)

Saar, Steven H.

1988-01-01

The paper presents several improved methods for the measurement of magnetic fields on cool stars which take into account simple radiative transfer effects and the exact Zeeman patterns. Using these methods, high-resolution, low-noise data can be fitted with theoretical line profiles to determine the mean magnetic field strength in stellar active regions and a model-dependent fraction of the stellar surface (filling factor) covered by these regions. Random errors in the derived field strength and filling factor are parameterized in terms of signal-to-noise ratio, wavelength, spectral resolution, stellar rotation rate, and the magnetic parameters themselves. Weak line blends, if left uncorrected, can have significant systematic effects on the derived magnetic parameters, and thus several methods are developed to compensate partially for them. The magnetic parameters determined by previous methods likely have systematic errors because of such line blends and because of line saturation effects. Other sources of systematic error are explored in detail. These sources of error currently make it difficult to determine the magnetic parameters of individual stars to better than about + or - 20 percent.

Giant Panda (Ailuropoda melanoleuca) Buccal Mucosa Tissue as a Source of Multipotent Progenitor Cells

PubMed Central

Prescott, Hilary M. A.; Manning, Craig; Gardner, Aaron; Ritchie, William A.; Pizzi, Romain; Girling, Simon; Valentine, Iain; Wang, Chengdong; Jahoda, Colin A. B.

2015-01-01

Since the first mammal was cloned, the idea of using this technique to help endangered species has aroused considerable interest. However, several issues limit this possibility, including the relatively low success rate at every stage of the cloning process, and the dearth of usable tissues from these rare animals. iPS cells have been produced from cells from a number of rare mammalian species and this is the method of choice for strategies to improve cloning efficiency and create new gametes by directed differentiation. Nevertheless information about other stem cell/progenitor capabilities of cells from endangered species could prove important for future conservation approaches and adds to the knowledge base about cellular material that can be extremely limited. Multipotent progenitor cells, termed skin-derived precursor (SKP) cells, can be isolated directly from mammalian skin dermis, and human cheek tissue has also been shown to be a good source of SKP-like cells. Recently we showed that structures identical to SKPs termed m-SKPs could be obtained from monolayer/ two dimensional (2D) skin fibroblast cultures. Here we aimed to isolate m-SKPs from cultured cells of three endangered species; giant panda (Ailuropoda melanoleuca); red panda (Ailurus fulgens); and Asiatic lion (Panthera leo persica). m-SKP-like spheres were formed from the giant panda buccal mucosa fibroblasts; whereas dermal fibroblast (DF) cells cultured from abdominal skin of the other two species were unable to generate spheres. Under specific differentiation culture conditions giant panda spheres expressed neural, Schwann, adipogenic and osteogenic cell markers. Furthermore, these buccal mucosa derived spheres were shown to maintain expression of SKP markers: nestin, versican, fibronectin, and P75 and switch on expression of the stem cell marker ABCG2. These results demonstrate that giant panda cheek skin can be a useful source of m-SKP multipotent progenitors. At present lack of sample numbers means that we can only postulate why we were unable to obtain m-SKPs from the lion and red panda cultures. However the giant panda observations point to the value of archiving cells from rare species, and the possibilities for later progenitor cell derivation. PMID:26398672

Giant Panda (Ailuropoda melanoleuca) Buccal Mucosa Tissue as a Source of Multipotent Progenitor Cells.

PubMed

Prescott, Hilary M A; Manning, Craig; Gardner, Aaron; Ritchie, William A; Pizzi, Romain; Girling, Simon; Valentine, Iain; Wang, Chengdong; Jahoda, Colin A B

2015-01-01

Since the first mammal was cloned, the idea of using this technique to help endangered species has aroused considerable interest. However, several issues limit this possibility, including the relatively low success rate at every stage of the cloning process, and the dearth of usable tissues from these rare animals. iPS cells have been produced from cells from a number of rare mammalian species and this is the method of choice for strategies to improve cloning efficiency and create new gametes by directed differentiation. Nevertheless information about other stem cell/progenitor capabilities of cells from endangered species could prove important for future conservation approaches and adds to the knowledge base about cellular material that can be extremely limited. Multipotent progenitor cells, termed skin-derived precursor (SKP) cells, can be isolated directly from mammalian skin dermis, and human cheek tissue has also been shown to be a good source of SKP-like cells. Recently we showed that structures identical to SKPs termed m-SKPs could be obtained from monolayer/ two dimensional (2D) skin fibroblast cultures. Here we aimed to isolate m-SKPs from cultured cells of three endangered species; giant panda (Ailuropoda melanoleuca); red panda (Ailurus fulgens); and Asiatic lion (Panthera leo persica). m-SKP-like spheres were formed from the giant panda buccal mucosa fibroblasts; whereas dermal fibroblast (DF) cells cultured from abdominal skin of the other two species were unable to generate spheres. Under specific differentiation culture conditions giant panda spheres expressed neural, Schwann, adipogenic and osteogenic cell markers. Furthermore, these buccal mucosa derived spheres were shown to maintain expression of SKP markers: nestin, versican, fibronectin, and P75 and switch on expression of the stem cell marker ABCG2. These results demonstrate that giant panda cheek skin can be a useful source of m-SKP multipotent progenitors. At present lack of sample numbers means that we can only postulate why we were unable to obtain m-SKPs from the lion and red panda cultures. However the giant panda observations point to the value of archiving cells from rare species, and the possibilities for later progenitor cell derivation.

Reconstructing source terms from atmospheric concentration measurements: Optimality analysis of an inversion technique

NASA Astrophysics Data System (ADS)

Turbelin, Grégory; Singh, Sarvesh Kumar; Issartel, Jean-Pierre

2014-12-01

In the event of an accidental or intentional contaminant release in the atmosphere, it is imperative, for managing emergency response, to diagnose the release parameters of the source from measured data. Reconstruction of the source information exploiting measured data is called an inverse problem. To solve such a problem, several techniques are currently being developed. The first part of this paper provides a detailed description of one of them, known as the renormalization method. This technique, proposed by Issartel (2005), has been derived using an approach different from that of standard inversion methods and gives a linear solution to the continuous Source Term Estimation (STE) problem. In the second part of this paper, the discrete counterpart of this method is presented. By using matrix notation, common in data assimilation and suitable for numerical computing, it is shown that the discrete renormalized solution belongs to a family of well-known inverse solutions (minimum weighted norm solutions), which can be computed by using the concept of generalized inverse operator. It is shown that, when the weight matrix satisfies the renormalization condition, this operator satisfies the criteria used in geophysics to define good inverses. Notably, by means of the Model Resolution Matrix (MRM) formalism, we demonstrate that the renormalized solution fulfils optimal properties for the localization of single point sources. Throughout the article, the main concepts are illustrated with data from a wind tunnel experiment conducted at the Environmental Flow Research Centre at the University of Surrey, UK.

The acoustic field of a point source in a uniform boundary layer over an impedance plane

NASA Technical Reports Server (NTRS)

Zorumski, W. E.; Willshire, W. L., Jr.

1986-01-01

The acoustic field of a point source in a boundary layer above an impedance plane is investigated anatytically using Obukhov quasi-potential functions, extending the normal-mode theory of Chunchuzov (1984) to account for the effects of finite ground-plane impedance and source height. The solution is found to be asymptotic to the surface-wave term studies by Wenzel (1974) in the limit of vanishing wind speed, suggesting that normal-mode theory can be used to model the effects of an atmospheric boundary layer on infrasonic sound radiation. Model predictions are derived for noise-generation data obtained by Willshire (1985) at the Medicine Bow wind-turbine facility. Long-range downwind propagation is found to behave as a cylindrical wave, with attention proportional to the wind speed, the boundary-layer displacement thickness, the real part of the ground admittance, and the square of the frequency.

Alternative energy sources

NASA Astrophysics Data System (ADS)

Todd, R. W.

1982-04-01

Renewable energy sources and their potential contribution for solving energy needs are presented. Centralized supply technologies include those alternative fuels derived from biomass using solar energy, (supplying 57% of the energy supply in some countries), and those using directly collected solar energy to manufacture a fuel. Fuel utilization effects can be doubled by using combined heat and power stations, and other major sources include wind, wave, tidal, and solar. In terms of local supply technology, wood burning appliances are becoming more popular, and methane is being used for heating and to fuel spark ignition engines. Geothermal low temperature heating exists worldwide at a capacity of 7.2 GW, supplying heat, particularly in Hungary, parts of the U.S.S.R., and Iceland, and a geothermal research program has been established in the United States. Sweden has a potential hydroelectric capacity of 600 MW, and the United States has a 100 GW capacity. Many of these technologies are already cost effective.

Phase-and-amplitude recovery from a single phase-contrast image using partially spatially coherent x-ray radiation

NASA Astrophysics Data System (ADS)

Beltran, Mario A.; Paganin, David M.; Pelliccia, Daniele

2018-05-01

A simple method of phase-and-amplitude extraction is derived that corrects for image blurring induced by partially spatially coherent incident illumination using only a single intensity image as input. The method is based on Fresnel diffraction theory for the case of high Fresnel number, merged with the space-frequency description formalism used to quantify partially coherent fields and assumes the object under study is composed of a single-material. A priori knowledge of the object’s complex refractive index and information obtained by characterizing the spatial coherence of the source is required. The algorithm was applied to propagation-based phase-contrast data measured with a laboratory-based micro-focus x-ray source. The blurring due to the finite spatial extent of the source is embedded within the algorithm as a simple correction term to the so-called Paganin algorithm and is also numerically stable in the presence of noise.

[Comparison between administrative and clinical databases in the evaluation of cardiac surgery performance].

PubMed

Rosato, Stefano; D'Errigo, Paola; Badoni, Gabriella; Fusco, Danilo; Perucci, Carlo A; Seccareccia, Fulvia

2008-08-01

The availability of two contemporary sources of information about coronary artery bypass graft (CABG) interventions, allowed 1) to verify the feasibility of performing outcome evaluation studies using administrative data sources, and 2) to compare hospital performance obtainable using the CABG Project clinical database with hospital performance derived from the use of current administrative data. Interventions recorded in the CABG Project were linked to the hospital discharge record (HDR) administrative database. Only the linked records were considered for subsequent analyses (46% of the total CABG Project). A new selected population "clinical card-HDR" was then defined. Two independent risk-adjustment models were applied, each of them using information derived from one of the two different sources. Then, HDR information was supplemented with some patient preoperative conditions from the CABG clinical database. The two models were compared in terms of their adaptability to data. Hospital performances identified by the two different models and significantly different from the mean was compared. In only 4 of the 13 hospitals considered for analysis, the results obtained using the HDR model did not completely overlap with those obtained by the CABG model. When comparing statistical parameters of the HDR model and the HDR model + patient preoperative conditions, the latter showed the best adaptability to data. In this "clinical card-HDR" population, hospital performance assessment obtained using information from the clinical database is similar to that derived from the use of current administrative data. However, when risk-adjustment models built on administrative databases are supplemented with a few clinical variables, their statistical parameters improve and hospital performance assessment becomes more accurate.

Higher-order formulas of amplitude-dependent tune shift caused by a sextupole magnetic field distribution

NASA Astrophysics Data System (ADS)

Soutome, Kouichi; Tanaka, Hitoshi

2017-06-01

Nowadays, designs for ring-based light sources use multibend lattices for achieving a very small emittance of around 100 pmrad. In this type of storage ring, the chromaticity correcting sextupoles generally have greater strengths than those used in typical third-generation light sources. Therefore, controlling lattice nonlinearity such as amplitude-dependent tune shift (ADTS) is important for enabling stable operations and smooth beam commissioning. As the strength of the sextupoles increases, their higher-order terms contribute significantly to ADTS, rendering well-known lowest-order formulas inadequate for describing tune variations at large horizontal amplitudes. In response, we have derived explicit expressions of ADTS up to the fourth order in sextupole strength based on the canonical perturbation theory, assuming that the amplitude of a vertical betatron oscillation is smaller compared with the horizontal one. The new formulas express the horizontal and vertical betatron tune variations as functions of the action variables: Jx and Jy up to O (Jx2) and O (Jy) . The derived formulas were applied to a five-bend achromat lattice designed for the SPring-8 upgrade. By comparing the calculated results with the tracking simulations, we found that (1) the formulas accurately express ADTS around a horizontal amplitude of ˜10 mm and (2) the nonlinear terms of the fourth order in sextupole strength govern the behaviors of circulating electrons at large horizontal amplitudes. In this paper, we present explicit expressions of fourth-order formulas of ADTS and provide some examples to illustrate their effectiveness.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biganzoli, Davide; Potenza, Marco A. C.; Robberto, Massimo, E-mail: robberto@stsci.edu

We discuss the radiative transfer theory for translucent clouds illuminated by an extended background source. First, we derive a rigorous solution based on the assumption that multiple scatterings produce an isotropic flux. Then we derive a more manageable analytic approximation showing that it nicely matches the results of the rigorous approach. To validate our model, we compare our predictions with accurate laboratory measurements for various types of well-characterized grains, including purely dielectric and strongly absorbing materials representative of astronomical icy and metallic grains, respectively, finding excellent agreement without the need to add free parameters. We use our model to exploremore » the behavior of an astrophysical cloud illuminated by a diffuse source with dust grains having parameters typical of the classic ISM grains of Draine and Lee and protoplanetary disks, with an application to the dark silhouette disk 114–426 in Orion Nebula. We find that the scattering term modifies the transmitted radiation, both in terms of intensity (extinction) and shape (reddening) of the spectral distribution. In particular, for small optical thickness, our results show that scattering makes reddening almost negligible at visible wavelengths. Once the optical thickness increases enough and the probability of scattering events becomes close to or larger than 1, reddening becomes present but is appreciably modified with respect to the standard expression for line-of-sight absorption. Moreover, variations of the grain refractive index, in particular the amount of absorption, also play an important role in changing the shape of the spectral transmission curve, with dielectric grains showing the minimum amount of reddening.« less

Vector image method for the derivation of elastostatic solutions for point sources in a plane layered medium. Part 1: Derivation and simple examples

NASA Technical Reports Server (NTRS)

Fares, Nabil; Li, Victor C.

1986-01-01

An image method algorithm is presented for the derivation of elastostatic solutions for point sources in bonded halfspaces assuming the infinite space point source is known. Specific cases were worked out and shown to coincide with well known solutions in the literature.

On epicardial potential reconstruction using regularization schemes with the L1-norm data term.

PubMed

Shou, Guofa; Xia, Ling; Liu, Feng; Jiang, Mingfeng; Crozier, Stuart

2011-01-07

The electrocardiographic (ECG) inverse problem is ill-posed and usually solved by regularization schemes. These regularization methods, such as the Tikhonov method, are often based on the L2-norm data and constraint terms. However, L2-norm-based methods inherently provide smoothed inverse solutions that are sensitive to measurement errors, and also lack the capability of localizing and distinguishing multiple proximal cardiac electrical sources. This paper presents alternative regularization schemes employing the L1-norm data term for the reconstruction of epicardial potentials (EPs) from measured body surface potentials (BSPs). During numerical implementation, the iteratively reweighted norm algorithm was applied to solve the L1-norm-related schemes, and measurement noises were considered in the BSP data. The proposed L1-norm data term-based regularization schemes (with L1 and L2 penalty terms of the normal derivative constraint (labelled as L1TV and L1L2)) were compared with the L2-norm data terms (Tikhonov with zero-order and normal derivative constraints, labelled as ZOT and FOT, and the total variation method labelled as L2TV). The studies demonstrated that, with averaged measurement noise, the inverse solutions provided by the L1L2 and FOT algorithms have less relative error values. However, when larger noise occurred in some electrodes (for example, signal lost during measurement), the L1TV and L1L2 methods can obtain more accurate EPs in a robust manner. Therefore the L1-norm data term-based solutions are generally less perturbed by measurement noises, suggesting that the new regularization scheme is promising for providing practical ECG inverse solutions.

Topological sources of soliton mass and supersymmetry breaking

NASA Astrophysics Data System (ADS)

Haas, Patrick A.

2018-06-01

We derive the Smarr formulae for two five-dimensional solutions of supergravity, which are asymptotically ; in particular, one has a magnetic ‘bolt’ in its center, and one is a two-center solution. We show for both spacetimes that supersymmetry—and so the BPS-bound—is broken by the holonomy and how each topological feature of a space-like hypersurface enters Smarr’s mass formula, with emphasis on the ones that give rise to the stated violation of the BPS-bound. In this light, we question if any violating extra-mass term in a spacetime with such asymptotics is only evident in the ADM mass while the Komar mass per se ‘tries’ to preserve BPS. Finally, we derive the cohomological fluxes for each situation and examine in a more general fashion how the breaking of supersymmetry—and so the BPS-bound violation—is associated with their topologies. In the second (and more complicated) scenario, we especially focus on the compact cycle linking the centers, and the contribution of non-vanishing bulk terms in the mass formula to the breaking of supersymmetry.

Measures and Relative Motions of Some Mostly F. G. W. Struve Doubles

NASA Astrophysics Data System (ADS)

Wiley, E. O.

2012-04-01

Measures of 59 pairs of double stars with long observational histories using "lucky imaging" techniques are reported. Relative motions of 59 pairs are investigated using histories of observation, scatter plots of relative motion, ordinary least-squares (OLS) and total proper motion analyses performed in "R," an open source programming language. A scatter plot of the coefficient of determinations derived from the OLS y|epoch and OLS x|epoch clearly separates common proper motion pairs from optical pairs and what are termed "long-period binary candidates." Differences in proper motion separate optical pairs from long-term binary candidates. An Appendix is provided that details how to use known rectilinear pairs as calibration pairs for the program REDUC.

Chemistry and combustion of fit-for-purpose biofuels.

PubMed

Rothamer, David A; Donohue, Timothy J

2013-06-01

From the inception of internal combustion engines, biologically derived fuels (biofuels) have played a role. Nicolaus Otto ran a predecessor to today's spark-ignition engine with an ethanol fuel blend in 1860. At the 1900 Paris world's fair, Rudolf Diesel ran his engine on peanut oil. Over 100 years of petroleum production has led to consistency and reliability of engines that demand standardized fuels. New biofuels can displace petroleum-based fuels and produce positive impacts on the environment, the economy, and the use of local energy sources. This review discusses the combustion, performance and other requirements of biofuels that will impact their near-term and long-term ability to replace petroleum fuels in transportation applications. Copyright © 2013 Elsevier Ltd. All rights reserved.

Development of axisymmetric lattice Boltzmann flux solver for complex multiphase flows

NASA Astrophysics Data System (ADS)

Wang, Yan; Shu, Chang; Yang, Li-Ming; Yuan, Hai-Zhuan

2018-05-01

This paper presents an axisymmetric lattice Boltzmann flux solver (LBFS) for simulating axisymmetric multiphase flows. In the solver, the two-dimensional (2D) multiphase LBFS is applied to reconstruct macroscopic fluxes excluding axisymmetric effects. Source terms accounting for axisymmetric effects are introduced directly into the governing equations. As compared to conventional axisymmetric multiphase lattice Boltzmann (LB) method, the present solver has the kinetic feature for flux evaluation and avoids complex derivations of external forcing terms. In addition, the present solver also saves considerable computational efforts in comparison with three-dimensional (3D) computations. The capability of the proposed solver in simulating complex multiphase flows is demonstrated by studying single bubble rising in a circular tube. The obtained results compare well with the published data.

Equations for determining aircraft motions for accident data

NASA Technical Reports Server (NTRS)

Bach, R. E., Jr.; Wingrove, R. C.

1980-01-01

Procedures for determining a comprehensive accident scenario from a limited data set are reported. The analysis techniques accept and process data from either an Air Traffic Control radar tracking system or a foil flight data recorder. Local meteorological information at the time of the accident and aircraft performance data are also utilized. Equations for the desired aircraft motions and forces are given in terms of elements of the measurement set and certain of their time derivatives. The principal assumption made is that aircraft side force and side-slip angle are negligible. An estimation procedure is outlined for use with each data source. For the foil case, a discussion of exploiting measurement redundancy is given. Since either formulation requires estimates of measurement time derivatives, an algorithm for least squares smoothing is provided.

Modern gyrokinetic formulation of collisional and turbulent transport in toroidally rotating plasmas

NASA Astrophysics Data System (ADS)

Sugama, H.

2017-12-01

Collisional and turbulent transport processes in toroidal plasmas with large toroidal flows on the order of the ion thermal velocity are formulated based on the modern gyrokinetic theory. Governing equations for background and turbulent electromagnetic fields and gyrocenter distribution functions are derived from the Lagrangian variational principle with effects of collisions and external sources taken into account. Noether's theorem modified for collisional systems and the collision operator given in terms of Poisson brackets are applied to derivation of the particle, energy, and toroidal momentum balance equations in the conservative forms which are desirable properties for long-time global transport simulation. The resultant balance equations are shown to include the classical, neoclassical, and turbulent transport fluxes which agree with those obtained from the conventional recursive formulations.

Radioactivity impacts of the Fukushima Nuclear Accident on the atmosphere

NASA Astrophysics Data System (ADS)

Lin, W.; Chen, L.; Yu, W.; Ma, H.; Zeng, Z.; Lin, J.; Zeng, S.

2015-02-01

The Fukushima Nuclear Accident (FNA) resulted in a large amount of radionuclides released into the atmosphere and dispersed globally, which has greatly raised public concerns. The state of the art for source terms of 19 kinds of radionuclides derived from the FNA was comprehensively collected and compared with levels of the global fallout and the Chernobyl Nuclear Accident (CNA). The atmospheric impacts of the FNA were evaluated from three aspects including radioactive baseline of the atmosphere, the concentration limits in standards and radiological protection. The FNA should not impose significant radiological risk on the public members in the countries excluding Japan. A conceptual scheme of Fukushima-derived radionuclides with physical and physicochemical insights on different temporal-spatial timescales was discussed and illustrated to understand their fates in the atmosphere.

Characterization of air manganese exposure estimates for residents in two Ohio towns

PubMed Central

Colledge, Michelle A.; Julian, Jaime R.; Gocheva, Vihra V.; Beseler, Cheryl L.; Roels, Harry A.; Lobdell, Danelle T.; Bowler, Rosemarie M.

2016-01-01

This study was conducted to derive receptor-specific outdoor exposure concentrations of total suspended particulate (TSP) and respirable (dae ≤ 10 μm) air manganese (air-Mn) for East Liverpool and Marietta (Ohio) in the absence of facility emissions data, but where long-term air measurements were available. Our “site-surface area emissions method” used U.S. Environmental Protection Agency’s (EPA) AERMOD (AMS/EPA Regulatory Model) dispersion model and air measurement data to estimate concentrations for residential receptor sites in the two communities. Modeled concentrations were used to create ratios between receptor points and calibrated using measured data from local air monitoring stations. Estimated outdoor air-Mn concentrations were derived for individual study subjects in both towns. The mean estimated long-term air-Mn exposure levels for total suspended particulate were 0.35 μg/m3 (geometric mean [GM]) and 0.88 μg/m3 (arithmetic mean [AM]) in East Liverpool (range: 0.014–6.32 μg/m3) and 0.17 μg/m3 (GM) and 0.21 μg/m3 (AM) in Marietta (range: 0.03–1.61 μg/m3). Modeled results compared well with averaged ambient air measurements from local air monitoring stations. Exposure to respirable Mn particulate matter (PM10; PM <10 μm) was higher in Marietta residents. Implications Few available studies evaluate long-term health outcomes from inhalational manganese (Mn) exposure in residential populations, due in part to challenges in measuring individual exposures. Local long-term air measurements provide the means to calibrate models used in estimating long-term exposures. Furthermore, this combination of modeling and ambient air sampling can be used to derive receptor-specific exposure estimates even in the absence of source emissions data for use in human health outcome studies. PMID:26211636

Building a drug ontology based on RxNorm and other sources

PubMed Central

2013-01-01

Background We built the Drug Ontology (DrOn) because we required correct and consistent drug information in a format for use in semantic web applications, and no existing resource met this requirement or could be altered to meet it. One of the obstacles we faced when creating DrOn was the difficulty in reusing drug information from existing sources. The primary external source we have used at this stage in DrOn’s development is RxNorm, a standard drug terminology curated by the National Library of Medicine (NLM). To build DrOn, we (1) mined data from historical releases of RxNorm and (2) mapped many RxNorm entities to Chemical Entities of Biological Interest (ChEBI) classes, pulling relevant information from ChEBI while doing so. Results We built DrOn in a modular fashion to facilitate simpler extension and development of the ontology and to allow reasoning and construction to scale. Classes derived from each source are serialized in separate modules. For example, the classes in DrOn that are programmatically derived from RxNorm are stored in a separate module and subsumed by classes in a manually-curated, realist, upper-level module of DrOn with terms such as 'clinical drug role’, 'tablet’, 'capsule’, etc. Conclusions DrOn is a modular, extensible ontology of drug products, their ingredients, and their biological activity that avoids many of the fundamental flaws found in other, similar artifacts and meets the requirements of our comparative-effectiveness research use-case. PMID:24345026

Building a drug ontology based on RxNorm and other sources.

PubMed

Hanna, Josh; Joseph, Eric; Brochhausen, Mathias; Hogan, William R

2013-12-18

We built the Drug Ontology (DrOn) because we required correct and consistent drug information in a format for use in semantic web applications, and no existing resource met this requirement or could be altered to meet it. One of the obstacles we faced when creating DrOn was the difficulty in reusing drug information from existing sources. The primary external source we have used at this stage in DrOn's development is RxNorm, a standard drug terminology curated by the National Library of Medicine (NLM). To build DrOn, we (1) mined data from historical releases of RxNorm and (2) mapped many RxNorm entities to Chemical Entities of Biological Interest (ChEBI) classes, pulling relevant information from ChEBI while doing so. We built DrOn in a modular fashion to facilitate simpler extension and development of the ontology and to allow reasoning and construction to scale. Classes derived from each source are serialized in separate modules. For example, the classes in DrOn that are programmatically derived from RxNorm are stored in a separate module and subsumed by classes in a manually-curated, realist, upper-level module of DrOn with terms such as 'clinical drug role', 'tablet', 'capsule', etc. DrOn is a modular, extensible ontology of drug products, their ingredients, and their biological activity that avoids many of the fundamental flaws found in other, similar artifacts and meets the requirements of our comparative-effectiveness research use-case.

Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior.

PubMed

Mandel, Yael; Weissman, Amir; Schick, Revital; Barad, Lili; Novak, Atara; Meiry, Gideon; Goldberg, Stanislav; Lorber, Avraham; Rosen, Michael R; Itskovitz-Eldor, Joseph; Binah, Ofer

2012-02-21

The sinoatrial node is the main impulse-generating tissue in the heart. Atrioventricular conduction block and arrhythmias caused by sinoatrial node dysfunction are clinically important and generally treated with electronic pacemakers. Although an excellent solution, electronic pacemakers incorporate limitations that have stimulated research on biological pacing. To assess the suitability of potential biological pacemakers, we tested the hypothesis that the spontaneous electric activity of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) exhibit beat rate variability and power-law behavior comparable to those of human sinoatrial node. We recorded extracellular electrograms from hESC-CMs and iPSC-CMs under stable conditions for up to 15 days. The beat rate time series of the spontaneous activity were examined in terms of their power spectral density and additional methods derived from nonlinear dynamics. The major findings were that the mean beat rate of hESC-CMs and iPSC-CMs was stable throughout the 15-day follow-up period and was similar in both cell types, that hESC-CMs and iPSC-CMs exhibited intrinsic beat rate variability and fractal behavior, and that isoproterenol increased and carbamylcholine decreased the beating rate in both hESC-CMs and iPSC-CMs. This is the first study demonstrating that hESC-CMs and iPSC-CMs exhibit beat rate variability and power-law behavior as in humans, thus supporting the potential capability of these cell sources to serve as biological pacemakers. Our ability to generate sinoatrial-compatible spontaneous cardiomyocytes from the patient's own hair (via keratinocyte-derived iPSCs), thus eliminating the critical need for immunosuppression, renders these myocytes an attractive cell source as biological pacemakers.

Eighteen-Year Cryopreservation Does Not Negatively Affect the Pluripotency of Human Embryos: Evidence from Embryonic Stem Cell Derivation

PubMed Central

Rungsiwiwut, Ruttachuk; Numchaisrika, Pranee; Ahnonkitpanit, Vichuda; Isarasena, Nipan; Virutamasen, Pramuan

2012-01-01

Abstract Human embryonic stem (hES) cells are considered to be a potential source for the therapy of human diseases, drug screening, and the study of developmental biology. In the present study, we successfully derived hES cell lines from blastocysts developed from frozen and fresh embryos. Seventeen- to eighteen-year-old frozen embryos were thawed, cultured to the blastocyst stage, and induced to form hES cells using human foreskin fibroblasts. The Chula2.hES cell line and the Chula4.hES and Chula5.hES cell lines were derived from blastocysts developed from frozen and fresh embryos, respectively. The cell lines expressed pluripotent markers, including alkaline phosphatase (AP), Oct3/4, stage-specific embryonic antigen (SSEA)-4, and tumor recognition antigen (TRA)-1-60 and TRA-1-81 as detected with immunocytochemistry. The real-time polymerase chain reaction (RT-PCR) results showed that the cell lines expressed pluripotent genes, including OCT3/4, SOX2, NANOG, UTF, LIN28, REX1, NODAL, and E-Cadherin. In addition, the telomerase activities of the cell lines were higher than in the fibroblast cells. Moreover, the cell lines differentiated into all three germ layers both in vitro and in vivo. The cell lines had distinct identities, as revealed with DNA fingerprinting, and maintained their normal karyotype after a long-term culture. This study is the first to report the successful derivation of hES cell lines in Thailand and that frozen embryos maintained their pluripotency similar to fresh embryos, as shown by the success of hES cell derivation, even after years of cryopreservation. Therefore, embryos from prolonged cryopreservation could be an alternative source for embryonic stem cell research. PMID:23514952

Guiding optimal biofuels :

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paap, Scott M.; West, Todd H.; Manley, Dawn Kataoka

2013-01-01

In the current study, processes to produce either ethanol or a representative fatty acid ethyl ester (FAEE) via the fermentation of sugars liberated from lignocellulosic materials pretreated in acid or alkaline environments are analyzed in terms of economic and environmental metrics. Simplified process models are introduced and employed to estimate process performance, and Monte Carlo analyses were carried out to identify key sources of uncertainty and variability. We find that the near-term performance of processes to produce FAEE is significantly worse than that of ethanol production processes for all metrics considered, primarily due to poor fermentation yields and higher electricitymore » demands for aerobic fermentation. In the longer term, the reduced cost and energy requirements of FAEE separation processes will be at least partially offset by inherent limitations in the relevant metabolic pathways that constrain the maximum yield potential of FAEE from biomass-derived sugars.« less

Energy and greenhouse gas profiles of polyhydroxybutyrates derived from corn grain: a life cycle perspective.

PubMed

Kim, Seungdo; Dale, Bruce E

2008-10-15

Polyhydroxybutyrates (PHB) are well-known biopolymers derived from sugars orvegetable oils. Cradle-to-gate environmental performance of PHB derived from corn grain is evaluated through life cycle assessment (LCA), particularly nonrenewable energy consumption and greenhouse gas emissions. Site-specific process information on the corn wet milling and PHB fermentation and recovery processes was obtained from Telles. Most of energy used in the corn wet milling and PHB fermentation and recovery processes is generated in a cogeneration power plant in which corn stover, assumed to be representative of a variety of biomass sources that could be used, is burned to generate electricity and steam. County level agricultural information is used in estimating the environmental burdens associated with both corn grain and corn stover production. Results show that PHB derived from corn grain offers environmental advantages over petroleum-derived polymers in terms of nonrenewable energy consumption and greenhouse gas emissions. Furthermore, PHB provides greenhouse gas credits, and thus PHB use reduces greenhouse gas emissions compared to petroleum-derived polymers. Corn cultivation is one of the environmentally sensitive areas in the PHB production system. More sustainable practices in corn cultivation (e.g., using no-tillage and winter cover crops) could reduce the environmental impacts of PHB by up to 72%.

Discriminating Simulated Vocal Tremor Source Using Amplitude Modulation Spectra

PubMed Central

Carbonell, Kathy M.; Lester, Rosemary A.; Story, Brad H.; Lotto, Andrew J.

2014-01-01

Objectives/Hypothesis Sources of vocal tremor are difficult to categorize perceptually and acoustically. This paper describes a preliminary attempt to discriminate vocal tremor sources through the use of spectral measures of the amplitude envelope. The hypothesis is that different vocal tremor sources are associated with distinct patterns of acoustic amplitude modulations. Study Design Statistical categorization methods (discriminant function analysis) were used to discriminate signals from simulated vocal tremor with different sources using only acoustic measures derived from the amplitude envelopes. Methods Simulations of vocal tremor were created by modulating parameters of a vocal fold model corresponding to oscillations of respiratory driving pressure (respiratory tremor), degree of vocal fold adduction (adductory tremor) and fundamental frequency of vocal fold vibration (F0 tremor). The acoustic measures were based on spectral analyses of the amplitude envelope computed across the entire signal and within select frequency bands. Results The signals could be categorized (with accuracy well above chance) in terms of the simulated tremor source using only measures of the amplitude envelope spectrum even when multiple sources of tremor were included. Conclusions These results supply initial support for an amplitude-envelope based approach to identify the source of vocal tremor and provide further evidence for the rich information about talker characteristics present in the temporal structure of the amplitude envelope. PMID:25532813

Homogenization of the Brush Problem with a Source Term in L 1

NASA Astrophysics Data System (ADS)

Gaudiello, Antonio; Guibé, Olivier; Murat, François

2017-07-01

We consider a domain which has the form of a brush in 3 D or the form of a comb in 2 D, i.e. an open set which is composed of cylindrical vertical teeth distributed over a fixed basis. All the teeth have a similar fixed height; their cross sections can vary from one tooth to another and are not supposed to be smooth; moreover the teeth can be adjacent, i.e. they can share parts of their boundaries. The diameter of every tooth is supposed to be less than or equal to ɛ, and the asymptotic volume fraction of the teeth (as ɛ tends to zero) is supposed to be bounded from below away from zero, but no periodicity is assumed on the distribution of the teeth. In this domain we study the asymptotic behavior (as ɛ tends to zero) of the solution of a second order elliptic equation with a zeroth order term which is bounded from below away from zero, when the homogeneous Neumann boundary condition is satisfied on the whole of the boundary. First, we revisit the problem where the source term belongs to L 2. This is a classical problem, but our homogenization result takes place in a geometry which is more general that the ones which have been considered before. Moreover we prove a corrector result which is new. Then, we study the case where the source term belongs to L 1. Working in the framework of renormalized solutions and introducing a definition of renormalized solutions for degenerate elliptic equations where only the vertical derivative is involved (such a definition is new), we identify the limit problem and prove a corrector result.

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

PubMed Central

Doi, Daisuke; Samata, Bumpei; Katsukawa, Mitsuko; Kikuchi, Tetsuhiro; Morizane, Asuka; Ono, Yuichi; Sekiguchi, Kiyotoshi; Nakagawa, Masato; Parmar, Malin; Takahashi, Jun

2014-01-01

Summary Human induced pluripotent stem cells (iPSCs) can provide a promising source of midbrain dopaminergic (DA) neurons for cell replacement therapy for Parkinson’s disease. However, iPSC-derived donor cells inevitably contain tumorigenic or inappropriate cells. Here, we show that human iPSC-derived DA progenitor cells can be efficiently isolated by cell sorting using a floor plate marker, CORIN. We induced DA neurons using scalable culture conditions on human laminin fragment, and the sorted CORIN+ cells expressed the midbrain DA progenitor markers, FOXA2 and LMX1A. When transplanted into 6-OHDA-lesioned rats, the CORIN+ cells survived and differentiated into midbrain DA neurons in vivo, resulting in significant improvement of the motor behavior, without tumor formation. In particular, the CORIN+ cells in a NURR1+ cell-dominant stage exhibited the best survival and function as DA neurons. Our method is a favorable strategy in terms of scalability, safety, and efficiency and may be advantageous for clinical application. PMID:24672756

EFFECTS OF PLANT PROTEIN DIETS ON THE HEALTH OF FARMED AMERICAN ALLIGATORS (ALLIGATOR MISSISSIPPIENSIS).

PubMed

DiGeronimo, Peter M; Di Girolamo, Nicola; Crossland, Nicholas A; Del Piero, Fabio; Reigh, Robert C; Nevarez, Javier G

2017-03-01

The objective of this prospective, blinded study was to compare plasma biochemical values and gross and histologic evaluation of kidney and liver from American alligators ( Alligator mississippiensis ) fed extruded diets with protein derived from animal or plant sources. Alligators in two treatment groups were fed an extruded diet with protein derived primarily from plant products for 7 (n = 20) or 10 (n = 20) mo prior to harvest. A control group (n = 20) was fed a commercial diet with protein derived from animal products for the duration of the study. Plasma biochemistry panels were obtained and gross and histologic examination of kidney and liver tissues was conducted for each animal. No differences were found between alligators fed diets with animal or plant protein in terms of either biochemistry profiles or gross or histologic examination of kidney and liver. Plant-based diets, fed for up to 10 mo, do not appear to have any ill effects on the kidney or liver of American alligators.

Modeling the Capacitive Deionization Process in Dual-Porosity Electrodes

DOE PAGES

Gabitto, Jorge; Tsouris, Costas

2016-04-28

In many areas of the world, there is a need to increase water availability. Capacitive deionization (CDI) is an electrochemical water treatment process that can be a viable alternative for treating water and for saving energy. A model is presented to simulate the CDI process in heterogeneous porous media comprising two different pore sizes. It is based on a theory for capacitive charging by ideally polarizable porous electrodes without Faradaic reactions or specific adsorption of ions. A two steps volume averaging technique is used to derive the averaged transport equations in the limit of thin electrical double layers. A one-equationmore » model based on the principle of local equilibrium is derived. The constraints determining the range of application of the one-equation model are presented. The effective transport parameters for isotropic porous media are calculated solving the corresponding closure problems. The source terms that appear in the average equations are calculated using theoretical derivations. The global diffusivity is calculated by solving the closure problem.« less

Interrogation of electrical connector faults using miniaturized UWB sources

NASA Astrophysics Data System (ADS)

Tokgöz, Çaǧata; Dardona, Sameh

2017-01-01

A diagnostic method for the detection, identification, and characterization of precursors of faults due to partial insertion of pin-socket contacts within electrical connectors commonly used in avionics systems is presented. It is demonstrated that a miniaturized ultrawideband (UWB) source and a minispectrum analyzer can be employed to measure resonant frequency shifts in connector S parameters as a small and low-cost alternative to a large and expensive network analyzer. The transfer function of an electrical connector is represented as a ratio of the spectra measured using the spectrum analyzer with and without the connector. Alternatively, the transfer function is derived in terms of the connector S parameters and the reflection coefficients at both ports of the connector. The transfer function data obtained using this derivation agreed well with its representation as a measured spectral ratio. The derivation enabled the extraction of the connector S parameters from the measured transfer function data as a function of the insertion depth of a pin-socket contact within the connector. In comparison with the S parameters measured directly using a network analyzer at multiple insertion depths, the S parameters extracted from the measured transfer function showed consistent and reliable representation of the electrical connector fault. The results demonstrate the potential of integrating a low-cost miniaturized UWB device into a connector harness for real-time detection of precursors to partially inserted connector faults.

Model falsifiability and climate slow modes

NASA Astrophysics Data System (ADS)

Essex, Christopher; Tsonis, Anastasios A.

2018-07-01

The most advanced climate models are actually modified meteorological models attempting to capture climate in meteorological terms. This seems a straightforward matter of raw computing power applied to large enough sources of current data. Some believe that models have succeeded in capturing climate in this manner. But have they? This paper outlines difficulties with this picture that derive from the finite representation of our computers, and the fundamental unavailability of future data instead. It suggests that alternative windows onto the multi-decadal timescales are necessary in order to overcome the issues raised for practical problems of prediction.

The HEAO-A2 soft X-ray survey of cataclysmic variable stars - EX Hydrae during optical quiescence

NASA Technical Reports Server (NTRS)

Cordova, F. A.; Riegler, G. R.

1979-01-01

Results are reported for HEAO A2 soft X-ray (below 2 keV) scanning observations of the southern dwarf nova EX Hya. An X-ray light curve is presented which shows no apparent orbital modulation. The best-fitting spectral parameters are derived for the source, and the observations are compared with the spectral behavior of the dwarf nova SS Cyg during optical quiescence. The results are discussed in terms of models for X-ray production by accreting white dwarfs.

Applications of seismic spatial wavefield gradient and rotation data in exploration seismology

NASA Astrophysics Data System (ADS)

Schmelzbach, C.; Van Renterghem, C.; Sollberger, D.; Häusler, M.; Robertsson, J. O. A.

2017-12-01

Seismic spatial wavefield gradient and rotation data have the potential to open up new ways to address long-standing problems in land-seismic exploration such as identifying and separating P-, S-, and surface waves. Gradient-based acquisition and processing techniques could enable replacing large arrays of densely spaced receivers by sparse spatially-compact receiver layouts or even one single multicomponent station with dedicated instruments (e.g., rotational seismometers). Such approaches to maximize the information content of single-station recordings are also of significant interest for seismic measurements at sites with limited access such as boreholes, the sea bottom, and extraterrestrial seismology. Arrays of conventional three-component (3C) geophones enable measuring not only the particle velocity in three dimensions but also estimating their spatial gradients. Because the free-surface condition allows to express vertical derivatives in terms of horizontal derivatives, the full gradient tensor and, hence, curl and divergence of the wavefield can be computed. In total, three particle velocity components, three rotational components, and divergence, result seven-component (7C) seismic data. Combined particle velocity and gradient data can be used to isolate the incident P- or S-waves at the land surface or the sea bottom using filtering techniques based on the elastodynamic representation theorem. Alternatively, as only S-waves exhibit rotational motion, rotational measurements can directly be used to identify S-waves. We discuss the derivations of the gradient-based filters as well as their application to synthetic and field data, demonstrating that rotational data can be of particular interest to S-wave reflection and P-to-S-wave conversion imaging. The concept of array-derived gradient estimation can be extended to source arrays as well. Therefore, source arrays allow us to emulate rotational (curl) and dilatational (divergence) sources. Combined with 7C recordings, a total of 49 components of the seismic wavefield can be excited and recorded. Such data potentially allow to further improve wavefield separation and may find application in directional imaging and coherent noise suppression.

Numerical models for the diffuse ionized gas in galaxies. I. Synthetic spectra of thermally excited gas with turbulent magnetic reconnection as energy source

NASA Astrophysics Data System (ADS)

Hoffmann, T. L.; Lieb, S.; Pauldrach, A. W. A.; Lesch, H.; Hultzsch, P. J. N.; Birk, G. T.

2012-08-01

Aims: The aim of this work is to verify whether turbulent magnetic reconnection can provide the additional energy input required to explain the up to now only poorly understood ionization mechanism of the diffuse ionized gas (DIG) in galaxies and its observed emission line spectra. Methods: We use a detailed non-LTE radiative transfer code that does not make use of the usual restrictive gaseous nebula approximations to compute synthetic spectra for gas at low densities. Excitation of the gas is via an additional heating term in the energy balance as well as by photoionization. Numerical values for this heating term are derived from three-dimensional resistive magnetohydrodynamic two-fluid plasma-neutral-gas simulations to compute energy dissipation rates for the DIG under typical conditions. Results: Our simulations show that magnetic reconnection can liberate enough energy to by itself fully or partially ionize the gas. However, synthetic spectra from purely thermally excited gas are incompatible with the observed spectra; a photoionization source must additionally be present to establish the correct (observed) ionization balance in the gas.

Unbound motion on a Schwarzschild background: Practical approaches to frequency domain computations

NASA Astrophysics Data System (ADS)

Hopper, Seth

2018-03-01

Gravitational perturbations due to a point particle moving on a static black hole background are naturally described in Regge-Wheeler gauge. The first-order field equations reduce to a single master wave equation for each radiative mode. The master function satisfying this wave equation is a linear combination of the metric perturbation amplitudes with a source term arising from the stress-energy tensor of the point particle. The original master functions were found by Regge and Wheeler (odd parity) and Zerilli (even parity). Subsequent work by Moncrief and then Cunningham, Price and Moncrief introduced new master variables which allow time domain reconstruction of the metric perturbation amplitudes. Here, I explore the relationship between these different functions and develop a general procedure for deriving new higher-order master functions from ones already known. The benefit of higher-order functions is that their source terms always converge faster at large distance than their lower-order counterparts. This makes for a dramatic improvement in both the speed and accuracy of frequency domain codes when analyzing unbound motion.

NSRD-15:Computational Capability to Substantiate DOE-HDBK-3010 Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Louie, David; Bignell, John; Dingreville, Remi Philippe Michel

Safety basis analysts throughout the U.S. Department of Energy (DOE) complex rely heavily on the information provided in the DOE Handbook, DOE-HDBK-3010, Airborne Release Fractions/Rates and Respirable Fractions for Nonreactor Nuclear Facilities, to determine radionuclide source terms from postulated accident scenarios. In calculating source terms, analysts tend to use the DOE Handbook’s bounding values on airborne release fractions (ARFs) and respirable fractions (RFs) for various categories of insults (representing potential accident release categories). This is typically due to both time constraints and the avoidance of regulatory critique. Unfortunately, these bounding ARFs/RFs represent extremely conservative values. Moreover, they were derived frommore » very limited small-scale bench/laboratory experiments and/or from engineered judgment. Thus, the basis for the data may not be representative of the actual unique accident conditions and configurations being evaluated. The goal of this research is to develop a more accurate and defensible method to determine bounding values for the DOE Handbook using state-of-art multi-physics-based computer codes.« less

Periodic cycles of social outbursts of activity

NASA Astrophysics Data System (ADS)

Berestycki, H.; Rossi, L.; Rodríguez, N.

2018-01-01

We study the long-time behavior of a 2 × 2 continuous dynamical system with a time-periodic source term which is either of cooperative-type or activator-inhibitor type. This system was recently introduced in the literature [2] to model the dynamics of social outbursts and consists of an explicit field measuring the level of activity and an implicit field measuring the effective tension. The system can be used to represent a general type of phenomena in which one variable exhibits self-excitement once the other variable has reached a critical value. The time-periodic source term allows one to analyze the effect that periodic external shocks to the system play in the dynamics of the outburst of activity. For cooperative systems we prove that for small shocks the level of activity dies down whereas, as the intensity of the shocks increases, the level of activity converges to a positive periodic solution (excited cycle). We further show that in some cases there is multiplicity of excited cycles. We derive a subset of these results for the activator-inhibitor system.

A high-order relaxation method with projective integration for solving nonlinear systems of hyperbolic conservation laws

NASA Astrophysics Data System (ADS)

Lafitte, Pauline; Melis, Ward; Samaey, Giovanni

2017-07-01

We present a general, high-order, fully explicit relaxation scheme which can be applied to any system of nonlinear hyperbolic conservation laws in multiple dimensions. The scheme consists of two steps. In a first (relaxation) step, the nonlinear hyperbolic conservation law is approximated by a kinetic equation with stiff BGK source term. Then, this kinetic equation is integrated in time using a projective integration method. After taking a few small (inner) steps with a simple, explicit method (such as direct forward Euler) to damp out the stiff components of the solution, the time derivative is estimated and used in an (outer) Runge-Kutta method of arbitrary order. We show that, with an appropriate choice of inner step size, the time step restriction on the outer time step is similar to the CFL condition for the hyperbolic conservation law. Moreover, the number of inner time steps is also independent of the stiffness of the BGK source term. We discuss stability and consistency, and illustrate with numerical results (linear advection, Burgers' equation and the shallow water and Euler equations) in one and two spatial dimensions.

Balanced Central Schemes for the Shallow Water Equations on Unstructured Grids

NASA Technical Reports Server (NTRS)

Bryson, Steve; Levy, Doron

2004-01-01

We present a two-dimensional, well-balanced, central-upwind scheme for approximating solutions of the shallow water equations in the presence of a stationary bottom topography on triangular meshes. Our starting point is the recent central scheme of Kurganov and Petrova (KP) for approximating solutions of conservation laws on triangular meshes. In order to extend this scheme from systems of conservation laws to systems of balance laws one has to find an appropriate discretization of the source terms. We first show that for general triangulations there is no discretization of the source terms that corresponds to a well-balanced form of the KP scheme. We then derive a new variant of a central scheme that can be balanced on triangular meshes. We note in passing that it is straightforward to extend the KP scheme to general unstructured conformal meshes. This extension allows us to recover our previous well-balanced scheme on Cartesian grids. We conclude with several simulations, verifying the second-order accuracy of our scheme as well as its well-balanced properties.

Modeling the contribution of point sources and non-point sources to Thachin River water pollution.

PubMed

Schaffner, Monika; Bader, Hans-Peter; Scheidegger, Ruth

2009-08-15

Major rivers in developing and emerging countries suffer increasingly of severe degradation of water quality. The current study uses a mathematical Material Flow Analysis (MMFA) as a complementary approach to address the degradation of river water quality due to nutrient pollution in the Thachin River Basin in Central Thailand. This paper gives an overview of the origins and flow paths of the various point- and non-point pollution sources in the Thachin River Basin (in terms of nitrogen and phosphorus) and quantifies their relative importance within the system. The key parameters influencing the main nutrient flows are determined and possible mitigation measures discussed. The results show that aquaculture (as a point source) and rice farming (as a non-point source) are the key nutrient sources in the Thachin River Basin. Other point sources such as pig farms, households and industries, which were previously cited as the most relevant pollution sources in terms of organic pollution, play less significant roles in comparison. This order of importance shifts when considering the model results for the provincial level. Crosschecks with secondary data and field studies confirm the plausibility of our simulations. Specific nutrient loads for the pollution sources are derived; these can be used for a first broad quantification of nutrient pollution in comparable river basins. Based on an identification of the sensitive model parameters, possible mitigation scenarios are determined and their potential to reduce the nutrient load evaluated. A comparison of simulated nutrient loads with measured nutrient concentrations shows that nutrient retention in the river system may be significant. Sedimentation in the slow flowing surface water network as well as nitrogen emission to the air from the warm oxygen deficient waters are certainly partly responsible, but also wetlands along the river banks could play an important role as nutrient sinks.

Fermi Large Area Telescope Second Source Catalog

NASA Astrophysics Data System (ADS)

Nolan, P. L.; Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Antolini, E.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Belfiore, A.; Bellazzini, R.; Berenji, B.; Bignami, G. F.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Bonnell, J.; Borgland, A. W.; Bottacini, E.; Bouvier, A.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Burnett, T. H.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Campana, R.; Cañadas, B.; Cannon, A.; Caraveo, P. A.; Casandjian, J. M.; Cavazzuti, E.; Ceccanti, M.; Cecchi, C.; Çelik, Ö.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Chipaux, R.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Corbet, R.; Cutini, S.; D'Ammando, F.; Davis, D. S.; de Angelis, A.; DeCesar, M. E.; DeKlotz, M.; De Luca, A.; den Hartog, P. R.; de Palma, F.; Dermer, C. D.; Digel, S. W.; Silva, E. do Couto e.; Drell, P. S.; Drlica-Wagner, A.; Dubois, R.; Dumora, D.; Enoto, T.; Escande, L.; Fabiani, D.; Falletti, L.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Fortin, P.; Frailis, M.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Germani, S.; Giebels, B.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Gustafsson, M.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Iafrate, G.; Itoh, R.; Jóhannesson, G.; Johnson, R. P.; Johnson, T. E.; Johnson, A. S.; Johnson, T. J.; Kamae, T.; Katagiri, H.; Kataoka, J.; Katsuta, J.; Kawai, N.; Kerr, M.; Knödlseder, J.; Kocevski, D.; Kuss, M.; Lande, J.; Landriu, D.; Latronico, L.; Lemoine-Goumard, M.; Lionetto, A. M.; Llena Garde, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Marelli, M.; Massaro, E.; Mazziotta, M. N.; McConville, W.; McEnery, J. E.; Mehault, J.; Michelson, P. F.; Minuti, M.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Mongelli, M.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Naumann-Godo, M.; Norris, J. P.; Nuss, E.; Nymark, T.; Ohno, M.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orlando, E.; Ormes, J. F.; Ozaki, M.; Paneque, D.; Panetta, J. H.; Parent, D.; Perkins, J. S.; Pesce-Rollins, M.; Pierbattista, M.; Pinchera, M.; Piron, F.; Pivato, G.; Porter, T. A.; Racusin, J. L.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Reposeur, T.; Ritz, S.; Rochester, L. S.; Romani, R. W.; Roth, M.; Rousseau, R.; Ryde, F.; Sadrozinski, H. F.-W.; Salvetti, D.; Sanchez, D. A.; Saz Parkinson, P. M.; Sbarra, C.; Scargle, J. D.; Schalk, T. L.; Sgrò, C.; Shaw, M. S.; Shrader, C.; Siskind, E. J.; Smith, D. A.; Spandre, G.; Spinelli, P.; Stephens, T. E.; Strickman, M. S.; Suson, D. J.; Tajima, H.; Takahashi, H.; Takahashi, T.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tibolla, O.; Tinebra, F.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Vandenbroucke, J.; Van Etten, A.; Van Klaveren, B.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Wallace, E.; Wang, P.; Werner, M.; Winer, B. L.; Wood, D. L.; Wood, K. S.; Wood, M.; Yang, Z.; Zimmer, S.

2012-04-01

We present the second catalog of high-energy γ-ray sources detected by the Large Area Telescope (LAT), the primary science instrument on the Fermi Gamma-ray Space Telescope (Fermi), derived from data taken during the first 24 months of the science phase of the mission, which began on 2008 August 4. Source detection is based on the average flux over the 24 month period. The second Fermi-LAT catalog (2FGL) includes source location regions, defined in terms of elliptical fits to the 95% confidence regions and spectral fits in terms of power-law, exponentially cutoff power-law, or log-normal forms. Also included are flux measurements in five energy bands and light curves on monthly intervals for each source. Twelve sources in the catalog are modeled as spatially extended. We provide a detailed comparison of the results from this catalog with those from the first Fermi-LAT catalog (1FGL). Although the diffuse Galactic and isotropic models used in the 2FGL analysis are improved compared to the 1FGL catalog, we attach caution flags to 162 of the sources to indicate possible confusion with residual imperfections in the diffuse model. The 2FGL catalog contains 1873 sources detected and characterized in the 100 MeV to 100 GeV range of which we consider 127 as being firmly identified and 1171 as being reliably associated with counterparts of known or likely γ-ray-producing source classes. We dedicate this paper to the memory of our colleague Patrick Nolan, who died on 2011 November 6. His career spanned much of the history of high-energy astronomy from space and his work on the Large Area Telescope (LAT) began nearly 20 years ago when it was just a concept. Pat was a central member in the operation of the LAT collaboration and he is greatly missed.

Mineralogy and geochemistry of claystones from the Guadalupian-Lopingian boundary at Penglaitan, South China: Insights into the pre-Lopingian geological events

NASA Astrophysics Data System (ADS)

Zhong, Yu-Ting; He, Bin; Xu, Yi-Gang

2013-01-01

The Guadalupian-Lopingian (G/L) boundary, at a stratigraphically well-documented outcrop in Penglaitan, Guangxi Autonomous Region, South China, has been approved as the Global Stratotype Section and Point (GSSP). Several volcanic ashes or tuffs occur at this boundary, but their mineralogy and geochemistry are not available yet and no reliable age for this boundary has been obtained. A combined study of mineralogy, geochemistry and geochronology has been carried out in this study on six layers of claystones collected below (Group 1) and above (Group 2) the G/L boundary at the Penglaitan section. Both Group 1 and Group 2 claystones are likely clastic in origin, rather than volcanic ashes as previously thought. Thus the Penglaitan claystones are not suitable for age determination of the G/L boundary. They are significantly different in terms of mineralogy and geochemistry. Specifically, Group 1 claystones are likely derived from a mafic source which is genetically related to the Emeishan large igneous province, therefore providing additional evidence for the synchroneity between the G/L boundary mass extinction and the Emeishan volcanism. Group 2 samples were derived from a felsic source, of which zircons yield an age spectrum peaked at 262 ± 3 Ma, undistinguishable within the uncertainty from the currently accepted G/L boundary age (260.4 ± 0.4 Ma). Nevertheless, Group 2 samples are not related to Emeishan volcanism, because their negative zircon ɛHf(t) values differ significantly from those of Emeishan magmas and trace element compositions of zircons are indicative of an arc source, rather than a within-plate source. In consideration of paleogeographic reconstruction, we propose that the Group 2 claystones may have been derived from continental arcs during the palaeo-Tethys evolution. This is the first sedimentary evidence for Permian continental arc in the northern margin of palaeo-Tethys.

Climate Change Studies over Bangalore using Multi-source Remote Sensing Data and GIS

NASA Astrophysics Data System (ADS)

B, S.; Gouda, K. C.; Laxmikantha, B. P.; Bhat, N.

2014-12-01

Urbanization is a form of metropolitan growth that is a response to often bewildering sets of economic, social, and political forces and to the physical geography of an area. Some of the causes of the sprawl include - population growth, economy, patterns of infrastructure initiatives like the construction of roads and the provision of infrastructure using public money encouraging development. The direct implication of such urban sprawl is the change in land use and land cover of the region. In this study the long term climate data from multiple sources like NCEP reanalysis, IMD observations and various satellite derived products from MAIRS, IMD, ERSL and TRMM are considered and analyzed using the developed algorithms for the better understanding of the variability in the climate parameters over Bangalore. These products are further mathematically analyzed to arrive at desired results by extracting land surface temperature (LST), Potential evapo-transmission (PET), Rainfall, Humidity etc. Various satellites products are derived from NASA (National Aeronautics Space Agency), Indian meteorological satellites and global satellites are helpful in massive study of urban issues at global and regional scale. Climate change analysis is well studied by using either single source data such as Temperature or Rainfall from IMD (Indian Meteorological Department) or combined data products available as in case of MAIRS (Monsoon Asia Integrated Regional Scale) program to get rainfall at regional scale. Finally all the above said parameters are normalized and analyzed with the help of various open source available software's for pre and post processing our requirements to obtain desired results. A sample of analysis i.e. the Inter annual variability of annual averaged Temperature over Bangalore is presented in figure 1, which clearly shows the rising trend of the temperature (0.06oC/year). Also the Land use and land cover (LULC) analysis over Bangalore, Day light hours from satellite derived products are analyzed and the correlation of climate parameters with LULC are presented.

Long term behavior of TEPCO FNPP1 derived radiocaesium in the North Pacific Ocean through the end of 2016: A review

NASA Astrophysics Data System (ADS)

Aoyama, Michio; Hamajima, Yasunori; Inomata, Yayoi; Kumamoto, Yuichiro; Oka, Eitarou; Tsubono, Takaki; Tsumune, Daisuke

2017-04-01

1, Two major source terms of radiocaesium to the Ocean There are two major sources of radionuclides to the environment derived by the TEPCO Fukushima Dai-ichi Nuclear Power Plant (FNPP1) accident in 2011. The largest and earliest source of artificial radionuclide was atmospheric release from three melt down cores of FNPP1, which led to atmospheric deposition on both land and in the ocean. Total amount of atmospheric release of 137Cs was estimated to be 15.2-20.4 PBq ( and same amount of 134Cs) (Aoyama et al., 2016). About 20 % of released radiocaesium fell on land and 80% of released radiocaesium fell on the ocean. Therefore 11.7-14.8 PBq of 137Cs was injected in the North Pacific as atmospheric deposition. Second largest source was the direct discharge of contaminated waters to the ocean since 26 March 2011 and peaked on 6 April 2011 (Tsumune et al., 2012). Total amount of directly released 137Cs was estimated to be 3.5 +- 0.7 PBq. A combined input to the North Pacific was therefore 15.2 - 18.3 PBq. 2, Three major pathways of FNPP1 derived radiocaesium in the North Pacific The fastest pathway of radiocaesium might be surface. FNPP1-derived radiocaesium injected at north of Kuroshio front by atmospheric deposition and direct discharge spread eastward in surface water by the North Pacific Current across the mid-latitude North Pacific (Aoyama et al., 2016). A model simulation by Tsubono et al.(2016) also shows good agreement with the observed radiocaesium activities in the North Pacific. The second pathway is formation of central mode water (CMW). A maximum of radiocaesium activity in June/July 2012 was observed at potential densities of 26.1-26.3 at 34 deg. N-39 deg. N along 165 deg. E, which correspond to 400 meters depth. The density is in a range of density of CMW and radiocaesium activity was higher than those in the surrounding waters, including STMW. In June-July 2015 and June 2016 at 36 deg. N-44 deg.N, 165 deg. E - 170 deg. E, we observe very week signal of FNPP1 radiocaesium, which means that subducted radiocaesium might have moved eastward from this region. The third pathway is formation of subtropical mode water (STMW). FNPP1-derived radiocaesium injected at south of Kuroshio front by atmospheric deposition transported to southward rapidly due to formation of STMW at potential densities of 25.1-25.3. In 2015 along 165 deg. E, FNPP1 radiocaesium corresponding STMW spread entire subtropical gyre and a part of them reached 2 deg. N and recirculated in the subtropical gyre and reached Japanese coast. 3, Mass balance of FNPP1 radiocaesium in the North Pacific 134Cs inventory was estimated to be 8 PBq in surface layer in summer 2012 (Inomata unpublished). Kaeriyama et al. (2016) estimated that 134Cs inventory in STWM in 2012 was about 4 PBq. We believe that FNPP1 derived 134Cs injected in the North Pacific was 15.2 - 18.3 PBq. Therefore 134Cs inventory can be estimated 3-6 PBq in CMW at this moment based on a mass balance of FNPP1 radiocaesium.

Long Range Transport was a Bigger NSS Source than DMS in the Remote Tropical MBL during PASE

NASA Astrophysics Data System (ADS)

Huebert, B. J.; Simpson, R. M.; Howell, S. G.; Blomquist, B.

2013-12-01

DMS was not the principal source of non-sea salt sulfate (NSS) mass in the remote marine boundary layer during the Pacific Atmospheric Sulfur Experiment (PASE), according to an Eulerian sulfur budget model based on chemical concentrations measured from the NCAR C-130 in the tropical Pacific. Each of our three (DMS, SO2, and NSS) self-consistent monthly- average budgets includes terms for surface exchange, entrainment, divergence, chemical formation, and chemical loss. The budget-derived DMS emission was (2.7 × 0.5 μmol m-2 d-1, our budget 'units'). SO2 sources include DMS + OH (1.4 × 0.4 units, assuming γ = 0.75) and entrainment from the free troposphere (FT) (0.8 × 0.2 units). Clouds were the most important chemical reactors for SO2 (-1.0 × 0.5 units). SO2 loss terms also include divergence (-0.9 × 0.3 units), dry deposition (-0.5 × 0.2 units), and OH + SO2 (-0.22 × 0.05 units). The total SO2 loss balanced the SO2 source. We found negligible NSS on particles from 2.6 μm to 10 μm diameter, the sea salt mass peak. Fine-particle NSS sources include in-cloud oxidation of SO2 by H2O2 (1.0 × 0.5 units), OH + SO2 (0.19 × 0.05 units), and entrainment (1.1 × 0.3 units in clean conditions; twice that when continental pollution is present). Only about 1/4 of emitted DMS becomes NSS. The NSS sources from entrainment and from DMS are similar in magnitude.

Atmospheric Tracer Inverse Modeling Using Markov Chain Monte Carlo (MCMC)

NASA Astrophysics Data System (ADS)

Kasibhatla, P.

2004-12-01

In recent years, there has been an increasing emphasis on the use of Bayesian statistical estimation techniques to characterize the temporal and spatial variability of atmospheric trace gas sources and sinks. The applications have been varied in terms of the particular species of interest, as well as in terms of the spatial and temporal resolution of the estimated fluxes. However, one common characteristic has been the use of relatively simple statistical models for describing the measurement and chemical transport model error statistics and prior source statistics. For example, multivariate normal probability distribution functions (pdfs) are commonly used to model these quantities and inverse source estimates are derived for fixed values of pdf paramaters. While the advantage of this approach is that closed form analytical solutions for the a posteriori pdfs of interest are available, it is worth exploring Bayesian analysis approaches which allow for a more general treatment of error and prior source statistics. Here, we present an application of the Markov Chain Monte Carlo (MCMC) methodology to an atmospheric tracer inversion problem to demonstrate how more gereral statistical models for errors can be incorporated into the analysis in a relatively straightforward manner. The MCMC approach to Bayesian analysis, which has found wide application in a variety of fields, is a statistical simulation approach that involves computing moments of interest of the a posteriori pdf by efficiently sampling this pdf. The specific inverse problem that we focus on is the annual mean CO2 source/sink estimation problem considered by the TransCom3 project. TransCom3 was a collaborative effort involving various modeling groups and followed a common modeling and analysis protocoal. As such, this problem provides a convenient case study to demonstrate the applicability of the MCMC methodology to atmospheric tracer source/sink estimation problems.

Analytical solution for the transient wave propagation of a buried cylindrical P-wave line source in a semi-infinite elastic medium with a fluid surface layer

NASA Astrophysics Data System (ADS)

Shan, Zhendong; Ling, Daosheng

2018-02-01

This article develops an analytical solution for the transient wave propagation of a cylindrical P-wave line source in a semi-infinite elastic solid with a fluid layer. The analytical solution is presented in a simple closed form in which each term represents a transient physical wave. The Scholte equation is derived, through which the Scholte wave velocity can be determined. The Scholte wave is the wave that propagates along the interface between the fluid and solid. To develop the analytical solution, the wave fields in the fluid and solid are defined, their analytical solutions in the Laplace domain are derived using the boundary and interface conditions, and the solutions are then decomposed into series form according to the power series expansion method. Each item of the series solution has a clear physical meaning and represents a transient wave path. Finally, by applying Cagniard's method and the convolution theorem, the analytical solutions are transformed into the time domain. Numerical examples are provided to illustrate some interesting features in the fluid layer, the interface and the semi-infinite solid. When the P-wave velocity in the fluid is higher than that in the solid, two head waves in the solid, one head wave in the fluid and a Scholte wave at the interface are observed for the cylindrical P-wave line source.

Statistical analysis of short-term water stress conditions at Riggs Creek OzFlux tower site

NASA Astrophysics Data System (ADS)

Azmi, Mohammad; Rüdiger, Christoph; Walker, Jeffrey P.

2017-10-01

A large range of indices and proxies are available to describe the water stress conditions of an area subject to different applications, which have varying capabilities and limitations depending on the prevailing local climatic conditions and land cover. The present study uses a range of spatio-temporally high-resolution (daily and within daily) data sources to evaluate a number of drought indices (DIs) for the Riggs Creek OzFlux tower site in southeastern Australia. Therefore, the main aim of this study is to evaluate the statistical characteristics of individual DIs subject to short-term water stress conditions. In order to derive a more general and therefore representative DI, a new criterion is required to specify the statistical similarity between each pair of indices to allow determining the dominant drought types along with their representative DIs. The results show that the monitoring of water stress at this case study area can be achieved by evaluating the individual behaviour of three clusters of (i) vegetation conditions, (ii) water availability and (iii) water consumptions. This indicates that it is not necessary to assess all individual DIs one by one to derive a comprehensive and informative data set about the water stress of an area; instead, this can be achieved by analysing one of the DIs from each cluster or deriving a new combinatory index for each cluster, based on established combination methods.

Viability and neural differentiation of mesenchymal stem cells derived from the umbilical cord following perinatal asphyxia.

PubMed

Aly, H; Mohsen, L; Badrawi, N; Gabr, H; Ali, Z; Akmal, D

2012-09-01

Hypoxia-ischemia is the leading cause of neurological handicaps in newborns worldwide. Mesenchymal stem cells (MSCs) collected from fresh cord blood of asphyxiated newborns have the potential to regenerate damaged neural tissues. The aim of this study was to examine the capacity for MSCs to differentiate into neural tissue that could subsequently be used for autologous transplantation. We collected cord blood samples from full-term newborns with perinatal hypoxemia (n=27), healthy newborns (n=14) and non-hypoxic premature neonates (n=14). Mononuclear cells were separated, counted, and then analyzed by flow cytometry to assess various stem cell populations. MSCs were isolated by plastic adherence and characterized by morphology. Cells underwent immunophenotyping and trilineage differentiation potential. They were then cultured in conditions favoring neural differentiation. Neural lineage commitment was detected using immunohistochemical staining for glial fibrillary acidic protein, tubulin III and oligodendrocyte marker O4 antibodies. Mononuclear cell count and viability did not differ among the three groups of infants. Neural differentiation was best demonstrated in the cells derived from hypoxia-ischemia term neonates, of which 69% had complete and 31% had partial neural differentiation. Cells derived from preterm neonates had the least amount of neural differentiation, whereas partial differentiation was observed in only 12%. These findings support the potential utilization of umbilical cord stem cells as a source for autologous transplant in asphyxiated neonates.

Response of lake chemistry to changes in atmospheric deposition and climate in three high-elevation wilderness areas of Colorado

USGS Publications Warehouse

Mast, M. Alisa; Turk, John T.; Clow, David W.; Campbell, Donald D.

2011-01-01

Trends in precipitation chemistry and hydrologic and climatic data were examined as drivers of long-term changes in the chemical composition of high-elevation lakes in three wilderness areas in Colorado during 1985-2008. Sulfate concentrations in precipitation decreased at a rate of -0.15 to -0.55 μeq/l/year at 10 high-elevation National Atmospheric Deposition Program stations in the state during 1987-2008 reflecting regional reductions in SO2 emissions. In lakes where sulfate is primarily derived from atmospheric inputs, sulfate concentrations also decreased although the rates generally were less, ranging from -0.12 to -0.27 μeq/l/year. The similarity in timing and sulfur isotopic data support the hypothesis that decreases in atmospheric deposition are driving the response of high-elevation lakes in some areas of the state. By contrast, in lakes where sulfate is derived primarily from watershed weathering sources, sulfate concentrations showed sharp increases during 1985-2008. Analysis of long-term climate records indicates that annual air temperatures have increased between 0.45 and 0.93°C per decade throughout most mountainous areas of Colorado, suggesting climate as a factor. Isotopic data reveal that sulfate in these lakes is largely derived from pyrite, which may indicate climate warming is preferentially affecting the rate of pyrite weathering.

Response of lake chemistry to changes in atmospheric deposition and climate in three high-elevation wilderness areas of Colorado

USGS Publications Warehouse

Mast, M.A.; Turk, J.T.; Clow, D.W.; Campbell, D.H.

2011-01-01

Trends in precipitation chemistry and hydrologic and climatic data were examined as drivers of long-term changes in the chemical composition of high-elevation lakes in three wilderness areas in Colorado during 1985-2008. Sulfate concentrations in precipitation decreased at a rate of -0.15 to -0.55 ??eq/l/year at 10 high-elevation National Atmospheric Deposition Program stations in the state during 1987-2008 reflecting regional reductions in SO2 emissions. In lakes where sulfate is primarily derived from atmospheric inputs, sulfate concentrations also decreased although the rates generally were less, ranging from -0.12 to -0.27 ??eq/l/year. The similarity in timing and sulfur isotopic data support the hypothesis that decreases in atmospheric deposition are driving the response of high-elevation lakes in some areas of the state. By contrast, in lakes where sulfate is derived primarily from watershed weathering sources, sulfate concentrations showed sharp increases during 1985-2008. Analysis of long-term climate records indicates that annual air temperatures have increased between 0.45 and 0.93??C per decade throughout most mountainous areas of Colorado, suggesting climate as a factor. Isotopic data reveal that sulfate in these lakes is largely derived from pyrite, which may indicate climate warming is preferentially affecting the rate of pyrite weathering. ?? 2010 US Government.

Re-Os isotopic evidence for an enriched-mantle source for the Noril'sk-type, ore-bearing intrusions, Siberia

USGS Publications Warehouse

Walker, R.J.; Morgan, J.W.; Horan, M.F.; Czamanske, G.K.; Krogstad, E.J.; Fedorenko, V.A.; Kunilov, V.E.

1994-01-01

Magmatic Cu-Ni sulfide ores and spatially associated ultramafic and mafic rocks from the Noril'sk I, Talnakh, and Kharaelakh intrusions are examined for Re-Os isotopic systematics. Neodymium and lead isotopic data also are reported for the ultramafic and mafic rocks. The Re-Os data for most samples indicate closed-system behavior since the ca. 250 Ma igneous crystallization age of the intrusions. There are small but significant differences in the initial osmium isotopic compositions of samples from the three intrusions. Ores from the Noril'sk I intrusion have ??Os values that vary from +0.4 to +8.8, but average +5.8. Ores from the Talnakh intrusion have ??Os values that range from +6.7 to +8.2, averaging +7.7. Ores from the Kharaelakh intrusion have ??Os values that range from +7.8 to +12.9, with an average value of +10.4. The osmium isotopic compositions of the ore samples from the Main Kharaelakh orebody exhibit minimal overlap with those for the Noril'sk I and Talnakh intrusions, indicating that these Kharaelakh ores were derived from a more radiogenic source of osmium than the other ores. Combined osmium and lead data for major orebodies in the three intrusions plot in three distinct fields, indicating derivation of osmium and lead from at least three isotopically distinct sources. Some of the variation in lead isotopic compositions may be the result of minor lower-crustal contamination. However, in contrast to most other isotopic and trace element data, Os-Pb variations are generally inconsistent with significant crustal contamination or interaction with the subcontinental lithosphere. Thus, the osmium and lead isotopic compositions of these intrusions probably reflect quite closely the compositions of their mantle source, and suggest that these two isotope systems were insensitive to lithospheric interaction. Ultramafic and mafic rocks have osmium and lead isotopic compositions that range only slightly beyond the compositions of the ores. These rocks also have relatively uniform ??{lunate}Nd values that range only from -0.8 to + 1.1. This limited variation in neodymium isotopic composition may reflect the characteristics of the mantle sources of the rocks, or it may indicate that somehow similar proportions of crust contaminated the parental melts. The osmium, lead, and neodymium isotopic data for these rocks most closely resemble the mantle sources of certain ocean island basalts (OIB), such as some Hawaiian basalts. Hence, these data are consistent with derivation of primary melts from a mantle source similar to that of some types of hotspot activity. The long-term Re/Os enrichment of this and similar mantle sources, relative to chondritic upper mantle, may reflect 1. (1) incorporation of recycled oceanic crust into the source more than 1 Ga ago, 2. (2) derivation from a mantle plume that originated at the outer core-lower mantle interface, or 3. (3) persistence of primordial stratification of rhenium and osmium in the mantle. ?? 1994.

The X-ray Spectral Evolution of eta Carinae as Seen by ASCA

NASA Technical Reports Server (NTRS)

Corcoran, M. F.; Fredericks, A. C.; Petre, R.; Swank, J. H.; Drake, S. A.; White, Nicholas E. (Technical Monitor)

2000-01-01

Using data from the ASCA X-ray observatory, we examine the variations in the X-ray spectrum of the supermassive star nu Carinae with an unprecedented combination of spatial and spectral resolution. We include data taken during the recent X-ray eclipse in 1997-1998, after recovery from the eclipse, and during and after an X-ray flare. We show that the eclipse variation in the X-ray spectrum is apparently confined to a decrease in the emission measure of the source. We compare our results with a simple colliding wind binary model and find that the observed spectral variations are only consistent, with the binary model if there is significant high-temperature emission far from the star and/or a substantial change in the temperature distribution of the hot plasma. If contamination in the 2-10 keV band is important, the observed eclipse spectrum requires an absorbing column in excess of 10(exp 24)/sq cm for consistency with the binary model, which may indicate an increase in the first derivative of M from nu Carinae near the time of periastron passage. The flare spectra are consistent with the variability seen in nearly simultaneous RXTE observations and thus confirm that nu Carinae itself is the source of the flare emission. The variation in the spectrum during the flare seems confined to a change in the source emission measure. By comparing 2 observations obtained at the same phase in different X-ray cycles, we find that the current, X-ray brightness of the source is slightly higher than the brightness of the source during the last cycle perhaps indicative of a long-term increase in the first derivative of M, not associated with the X-ray cycle.

Human Embryonic Stem Cell-Derived Mesenchymal Stroma Cells (hES-MSCs) Engraft In Vivo and Support Hematopoiesis without Suppressing Immune Function: Implications for Off-The Shelf ES-MSC Therapies

PubMed Central

Li, Ou; Tormin, Ariane; Sundberg, Berit; Hyllner, Johan; Le Blanc, Katarina; Scheding, Stefan

2013-01-01

Mesenchymal stroma cells (MSCs) have a high potential for novel cell therapy approaches in clinical transplantation. Commonly used bone marrow-derived MSCs (BM-MSCs), however, have a restricted proliferative capacity and cultures are difficult to standardize. Recently developed human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) might represent an alternative and unlimited source of hMSCs. We therefore compared human ES-cell-derived MSCs (hES-MP002.5 cells) to normal human bone marrow-derived MSCs (BM-MSCs). hES-MP002.5 cells had lower yet reasonable CFU-F capacity compared with BM-MSC (8±3 versus 29±13 CFU-F per 100 cells). Both cell types showed similar immunophenotypic properties, i.e. cells were positive for CD105, CD73, CD166, HLA-ABC, CD44, CD146, CD90, and negative for CD45, CD34, CD14, CD31, CD117, CD19, CD 271, SSEA-4 and HLA-DR. hES-MP002.5 cells, like BM-MSCs, could be differentiated into adipocytes, osteoblasts and chondrocytes in vitro. Neither hES-MP002.5 cells nor BM-MSCs homed to the bone marrow of immune-deficient NSG mice following intravenous transplantation, whereas intra-femoral transplantation into NSG mice resulted in engraftment for both cell types. In vitro long-term culture-initiating cell assays and in vivo co-transplantation experiments with cord blood CD34+ hematopoietic cells demonstrated furthermore that hES-MP002.5 cells, like BM-MSCs, possess potent stroma support function. In contrast to BM-MSCs, however, hES-MP002.5 cells showed no or only little activity in mixed lymphocyte cultures and phytohemagglutinin (PHA) lymphocyte stimulation assays. In summary, ES-cell derived MSCs might be an attractive unlimited source for stroma transplantation approaches without suppressing immune function. PMID:23383153

Use of Satellite Observations for Long-Term Exposure Assessment of Global Concentrations of Fine Particulate Matter

PubMed Central

Martin, Randall V.; Brauer, Michael; Boys, Brian L.

2014-01-01

Background: More than a decade of satellite observations offers global information about the trend and magnitude of human exposure to fine particulate matter (PM2.5). Objective: In this study, we developed improved global exposure estimates of ambient PM2.5 mass and trend using PM2.5 concentrations inferred from multiple satellite instruments. Methods: We combined three satellite-derived PM2.5 sources to produce global PM2.5 estimates at about 10 km × 10 km from 1998 through 2012. For each source, we related total column retrievals of aerosol optical depth to near-ground PM2.5 using the GEOS–Chem chemical transport model to represent local aerosol optical properties and vertical profiles. We collected 210 global ground-based PM2.5 observations from the literature to evaluate our satellite-based estimates with values measured in areas other than North America and Europe. Results: We estimated that global population-weighted ambient PM2.5 concentrations increased 0.55 μg/m3/year (95% CI: 0.43, 0.67) (2.1%/year; 95% CI: 1.6, 2.6) from 1998 through 2012. Increasing PM2.5 in some developing regions drove this global change, despite decreasing PM2.5 in some developed regions. The estimated proportion of the population of East Asia living above the World Health Organization (WHO) Interim Target-1 of 35 μg/m3 increased from 51% in 1998–2000 to 70% in 2010–2012. In contrast, the North American proportion above the WHO Air Quality Guideline of 10 μg/m3 fell from 62% in 1998–2000 to 19% in 2010–2012. We found significant agreement between satellite-derived estimates and ground-based measurements outside North America and Europe (r = 0.81; n = 210; slope = 0.68). The low bias in satellite-derived estimates suggests that true global concentrations could be even greater. Conclusions: Satellite observations provide insight into global long-term changes in ambient PM2.5 concentrations. Satellite-derived estimates and ground-based PM2.5 observations from this study are available for public use. Citation: van Donkelaar A, Martin RV, Brauer M, Boys BL. 2015. Use of satellite observations for long-term exposure assessment of global concentrations of fine particulate matter. Environ Health Perspect 123:135–143; http://dx.doi.org/10.1289/ehp.1408646 PMID:25343779

Amniotic Mesenchymal Stromal Cells Exhibit Preferential Osteogenic and Chondrogenic Differentiation and Enhanced Matrix Production Compared With Adipose Mesenchymal Stromal Cells.

PubMed

Topoluk, Natasha; Hawkins, Richard; Tokish, John; Mercuri, Jeremy

2017-09-01

Therapeutic efficacy of various mesenchymal stromal cell (MSC) types for orthopaedic applications is currently being investigated. While the concept of MSC therapy is well grounded in the basic science of healing and regeneration, little is known about individual MSC populations in terms of their propensity to promote the repair and/or regeneration of specific musculoskeletal tissues. Two promising MSC sources, adipose and amnion, have each demonstrated differentiation and extracellular matrix (ECM) production in the setting of musculoskeletal tissue regeneration. However, no study to date has directly compared the differentiation potential of these 2 MSC populations. To compare the ability of human adipose- and amnion-derived MSCs to undergo osteogenic and chondrogenic differentiation. Controlled laboratory study. MSC populations from the human term amnion were quantified and characterized via cell counting, histologic assessment, and flow cytometry. Differentiation of these cells in comparison to commercially purchased human adipose-derived mesenchymal stromal cells (hADSCs) in the presence and absence of differentiation media was evaluated via reverse transcription polymerase chain reaction (PCR) for bone and cartilage gene transcript markers and histology/immunohistochemistry to examine ECM production. Analysis of variance and paired t tests were performed to compare results across all cell groups investigated. The authors confirmed that the human term amnion contains 2 primary cell types demonstrating MSC characteristics-(1) human amniotic epithelial cells (hAECs) and (2) human amniotic mesenchymal stromal cells (hAMSCs)-and each exhibited more than 90% staining for MSC surface markers (CD90, CD105, CD73). Average viable hAEC and hAMSC yields at harvest were 2.3 × 10 6 ± 3.7 × 10 5 and 1.6 × 10 6 ± 4.7 × 10 5 per milliliter of amnion, respectively. As well, hAECs and hAMSCs demonstrated significantly greater osteocalcin ( P = .025), aggrecan ( P < .0001), and collagen type 2 ( P = .044) gene expression compared with hADSCs, respectively, after culture in differentiation medium. Moreover, both hAECs and hAMSCs produced significantly greater quantities of mineralized ( P < .0001) and cartilaginous ( P = .0004) matrix at earlier time points compared with hADSCs when cultured under identical osteogenic and chondrogenic differentiation conditions, respectively. Amnion-derived MSCs demonstrate a greater differentiation potential toward bone and cartilage compared with hADSCs. Amniotic MSCs may be the source of choice in the regenerative treatment of bone or osteochondral musculoskeletal disease. They show significantly higher yields and better differentiation toward these tissues than MSCs derived from adipose.

Biomarkers in sedimentary sequences: Indicators to track sediment sources over decadal timescales

NASA Astrophysics Data System (ADS)

Chen, F. X.; Fang, N. F.; Wang, Y. X.; Tong, L. S.; Shi, Z. H.

2017-02-01

Long-term sedimentary sequence research can reveal how human activities and climate interact to affect catchment vegetation, flooding, soil erosion, and sediment sources. In this study, a biomarker sediment fingerprinting technique based on n-alkanes was used to identify long timescale (decadal) sediment sources in a small agricultural catchment. However, the highly saline carbonate environment and bacterial and algal activities elevated the levels of even-chain n-alkanes in the sediments, leading to an obvious even-over-odd predominance of short and middle components (C15-C26). Therefore, by analyzing three odd, long-chain n-alkanes (C27, C29 and C31) in 27 source samples from cropland, gully, and steep slope areas and one sediment sequence (one cultivated horizon and 47 flood couplets), a composite fingerprinting method and genetic algorithm optimization were applied to find the optimal source contributions to sediments. The biomarker fingerprinting results demonstrated that the primary sediment source is gullies, followed by cropland and steep slope areas. The average median source contributions associated with 47 flood couples collected from sediment core samples ranged from 0 ± 0.1% to 91.9 ± 0.4% with an average of 45.0% for gullies, 0 ± 0.4% to 95.6 ± 1.6% with an average of 38.2% for cropland, and 0 ± 2.1% to 60.7 ± 0.4% with an average of 16.8% for steep slopes. However, because farmers were highly motivated to manage the cropland after the 1980s, over half the sediments were derived from cropland in the 1980s. Biomarkers have significant advantages in the identification of sediments derived from different landscape units (e.g., gully and steep slope areas), and n-alkanes have considerable potential in high-resolution research of environmental change based on soil erosion in the hilly Loess Plateau region.

A finite element formulation for supersonic flows around complex configurations

NASA Technical Reports Server (NTRS)

Morino, L.

1974-01-01

The problem of small perturbation potential supersonic flow around complex configurations is considered. This problem requires the solution of an integral equation relating the values of the potential on the surface of the body to the values of the normal derivative, which is known from the small perturbation boundary conditions. The surface of the body is divided into small (hyperboloidal quadrilateral) surface elements which are described in terms of the Cartesian components of the four corner points. The values of the potential (and its normal derivative) within each element are assumed to be constant and equal to its value at the centroid of the element. This yields a set of linear algebraic equations whose coefficients are given by source and doublet integrals over the surface elements. Closed form evaluations of the integrals are presented.

Spectral analysis of variable-length coded digital signals

NASA Astrophysics Data System (ADS)

Cariolaro, G. L.; Pierobon, G. L.; Pupolin, S. G.

1982-05-01

A spectral analysis is conducted for a variable-length word sequence by an encoder driven by a stationary memoryless source. A finite-state sequential machine is considered as a model of the line encoder, and the spectral analysis of the encoded message is performed under the assumption that the sourceword sequence is composed of independent identically distributed words. Closed form expressions for both the continuous and discrete parts of the spectral density are derived in terms of the encoder law and sourceword statistics. The jump part exhibits jumps at multiple integers of per lambda(sub 0)T, where lambda(sub 0) is the greatest common divisor of the possible codeword lengths, and T is the symbol period. The derivation of the continuous part can be conveniently factorized, and the theory is applied to the spectral analysis of BnZS and HDBn codes.

Radiative transfer of X-rays in the solar corona

NASA Technical Reports Server (NTRS)

Acton, L. W.

1978-01-01

The problem of resonance scattering of X-ray emission lines in the solar corona is investigated. For the resonance lines of some helium-like ions, significant optical depths are reached over distances small compared with the size of typical coronal features. A general integral equation for the transfer of resonance-line radiation under solar coronal conditions is derived. This expression is in a form useful for modeling the complex three-dimensional temperature and density structure of coronal active regions. The transfer equation is then cast in a form illustrating the terms which give rise to the attenuation or enhancement of the resonance-line intensity. The source function for helium-like oxygen (O VII) under coronal conditions is computed and discussed in terms of the relative importance of scattering.

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells

PubMed Central

Gori, Jennifer L.; Butler, Jason M.; Chan, Yan-Yi; Chandrasekaran, Devikha; Poulos, Michael G.; Ginsberg, Michael; Nolan, Daniel J.; Elemento, Olivier; Wood, Brent L.; Adair, Jennifer E.; Rafii, Shahin; Kiem, Hans-Peter

2015-01-01

Pluripotent stem cells (PSCs) represent an alternative hematopoietic stem cell (HSC) source for treating hematopoietic disease. The limited engraftment of human PSC–derived (hPSC-derived) multipotent progenitor cells (MPP) has hampered the clinical application of these cells and suggests that MPP require additional cues for definitive hematopoiesis. We hypothesized that the presence of a vascular niche that produces Notch ligands jagged-1 (JAG1) and delta-like ligand-4 (DLL4) drives definitive hematopoiesis. We differentiated hes2 human embryonic stem cells (hESC) and Macaca nemestrina–induced PSC (iPSC) line-7 with cytokines in the presence or absence of endothelial cells (ECs) that express JAG1 and DLL4. Cells cocultured with ECs generated substantially more CD34+CD45+ hematopoietic progenitors compared with cells cocultured without ECs or with ECs lacking JAG1 or DLL4. EC-induced cells exhibited Notch activation and expressed HSC-specific Notch targets RUNX1 and GATA2. EC-induced PSC-MPP engrafted at a markedly higher level in NOD/SCID/IL-2 receptor γ chain–null (NSG) mice compared with cytokine-induced cells, and low-dose chemotherapy-based selection further increased engraftment. Long-term engraftment and the myeloid-to-lymphoid ratio achieved with vascular niche induction were similar to levels achieved for cord blood–derived MPP and up to 20-fold higher than those achieved with hPSC-derived MPP engraftment. Our findings indicate that endothelial Notch ligands promote PSC-definitive hematopoiesis and production of long-term engrafting CD34+ cells, suggesting these ligands are critical for HSC emergence. PMID:25664855

Some new methods in geomagnetic field modeling applied to the 1960 - 1980 epoch

NASA Technical Reports Server (NTRS)

Langel, R. A.; Estes, R. H.; Mead, G. H.

1981-01-01

The utilization of satellite and surface data together permitted the incorporation of a solution for the anomaly field at each observatory. The residuals of the observatory measurements to such models is commensurate with the actual measurment accuracy. Incorporation of the anomaly estimation enabled the inclusion of stable time derivatives of the spherical harmonic coefficients up to the third derivative. A spherical harmonic model is derived with degree and order 13 in its constant and first time derivative terms, six in its second derivative terms and four in its third derivative terms.

PBMC are as good a source of tumor-reactive T lymphocytes as TIL after selection by Melan-A/A2 multimer immunomagnetic sorting.

PubMed

Labarrière, Nathalie; Gervois, Nadine; Bonnin, Annabelle; Bouquié, Régis; Jotereau, Francine; Lang, François

2008-02-01

Choosing a reliable source of tumor-specific T lymphocytes and an efficient method to isolate these cells still remains a critical issue in adoptive cellular therapy (ACT). In this study, we assessed the capacity of MHC/peptide based immunomagnetic sorting followed by polyclonal T cell expansion to derive pure polyclonal and tumor-reactive Melan-A specific T cell populations from melanoma patient's PBMC and TIL. We first demonstrated that this approach was extremely efficient and reproducible. We then used this procedure to compare PBMC and TIL-derived cells from three melanoma patients in terms of avidity for Melan-A A27L analog, Melan-A(26-35)and Melan-A(27-35), tumor reactivity (lysis and cytokine production) and repertoire. Regardless of their origin, i.e., fresh PBMC, peptide stimulated PBMC or TIL, all sorted populations (from the three patients) were cytotoxic against HLA-A2+ melanoma cell lines expressing Melan-A. Although some variability in peptide avidity, lytic activity and cytokine production was observed between populations of different origins in a given patient, it differed from one patient to another and thus no correlation could be drawn between T cell source and reactivity. Analysis of Vbeta usage within the sorted populations showed the recurrence of Vbeta3 and Vbeta14 subfamilies in the three patients but differences in the rest of the Melan-A repertoire. In addition, in two patients, we observed major repertoire differences between populations sorted from the three sources. We especially documented that in vitro peptide stimulation of PBMC, used to facilitate the sort by enriching in specific T lymphocytes, could significantly alter their repertoire and reactivity towards tumor cells. We conclude that PBMC which are easily obtained from all melanoma patients, can be as good a source as TIL to derive high amounts of tumor-reactive Melan-A specific T cells, with this selection/amplification procedure. However, the conditions of peptide stimulation should be improved to prevent a possible loss of reactive clonotypes.

Background field removal using a region adaptive kernel for quantitative susceptibility mapping of human brain

NASA Astrophysics Data System (ADS)

Fang, Jinsheng; Bao, Lijun; Li, Xu; van Zijl, Peter C. M.; Chen, Zhong

2017-08-01

Background field removal is an important MR phase preprocessing step for quantitative susceptibility mapping (QSM). It separates the local field induced by tissue magnetic susceptibility sources from the background field generated by sources outside a region of interest, e.g. brain, such as air-tissue interface. In the vicinity of air-tissue boundary, e.g. skull and paranasal sinuses, where large susceptibility variations exist, present background field removal methods are usually insufficient and these regions often need to be excluded by brain mask erosion at the expense of losing information of local field and thus susceptibility measures in these regions. In this paper, we propose an extension to the variable-kernel sophisticated harmonic artifact reduction for phase data (V-SHARP) background field removal method using a region adaptive kernel (R-SHARP), in which a scalable spherical Gaussian kernel (SGK) is employed with its kernel radius and weights adjustable according to an energy "functional" reflecting the magnitude of field variation. Such an energy functional is defined in terms of a contour and two fitting functions incorporating regularization terms, from which a curve evolution model in level set formation is derived for energy minimization. We utilize it to detect regions of with a large field gradient caused by strong susceptibility variation. In such regions, the SGK will have a small radius and high weight at the sphere center in a manner adaptive to the voxel energy of the field perturbation. Using the proposed method, the background field generated from external sources can be effectively removed to get a more accurate estimation of the local field and thus of the QSM dipole inversion to map local tissue susceptibility sources. Numerical simulation, phantom and in vivo human brain data demonstrate improved performance of R-SHARP compared to V-SHARP and RESHARP (regularization enabled SHARP) methods, even when the whole paranasal sinus regions are preserved in the brain mask. Shadow artifacts due to strong susceptibility variations in the derived QSM maps could also be largely eliminated using the R-SHARP method, leading to more accurate QSM reconstruction.

Background field removal using a region adaptive kernel for quantitative susceptibility mapping of human brain.

PubMed

Fang, Jinsheng; Bao, Lijun; Li, Xu; van Zijl, Peter C M; Chen, Zhong

2017-08-01

Background field removal is an important MR phase preprocessing step for quantitative susceptibility mapping (QSM). It separates the local field induced by tissue magnetic susceptibility sources from the background field generated by sources outside a region of interest, e.g. brain, such as air-tissue interface. In the vicinity of air-tissue boundary, e.g. skull and paranasal sinuses, where large susceptibility variations exist, present background field removal methods are usually insufficient and these regions often need to be excluded by brain mask erosion at the expense of losing information of local field and thus susceptibility measures in these regions. In this paper, we propose an extension to the variable-kernel sophisticated harmonic artifact reduction for phase data (V-SHARP) background field removal method using a region adaptive kernel (R-SHARP), in which a scalable spherical Gaussian kernel (SGK) is employed with its kernel radius and weights adjustable according to an energy "functional" reflecting the magnitude of field variation. Such an energy functional is defined in terms of a contour and two fitting functions incorporating regularization terms, from which a curve evolution model in level set formation is derived for energy minimization. We utilize it to detect regions of with a large field gradient caused by strong susceptibility variation. In such regions, the SGK will have a small radius and high weight at the sphere center in a manner adaptive to the voxel energy of the field perturbation. Using the proposed method, the background field generated from external sources can be effectively removed to get a more accurate estimation of the local field and thus of the QSM dipole inversion to map local tissue susceptibility sources. Numerical simulation, phantom and in vivo human brain data demonstrate improved performance of R-SHARP compared to V-SHARP and RESHARP (regularization enabled SHARP) methods, even when the whole paranasal sinus regions are preserved in the brain mask. Shadow artifacts due to strong susceptibility variations in the derived QSM maps could also be largely eliminated using the R-SHARP method, leading to more accurate QSM reconstruction. Copyright © 2017. Published by Elsevier Inc.

Compound-specific isotopic analyses: a novel tool for reconstruction of ancient biogeochemical processes

NASA Technical Reports Server (NTRS)

Hayes, J. M.; Freeman, K. H.; Popp, B. N.; Hoham, C. H.

1990-01-01

Patterns of isotopic fractionation in biogeochemical processes are reviewed and it is suggested that isotopic fractionations will be small when substrates are large. If so, isotopic compositions of biomarkers will reflect those of their biosynthetic precursors. This prediction is tested by consideration of results of analyses of geoporphyrins and geolipids from the Greenhorn Formation (Cretaceous, Western Interior Seaway of North America) and the Messel Shale (Eocene, lacustrine, southern Germany). It is shown (i) that isotopic compositions of porphyrins that are related to a common source, but which have been altered structurally, cluster tightly and (ii) that isotopic differences between geolipids and porphyrins related to a common source are equal to those observed in modern biosynthetic products. Both of these observations are consistent with preservation of biologically controlled isotopic compositions during diagenesis. Isotopic compositions of individual compounds can thus be interpreted in terms of biogeochemical processes in ancient depositional environments. In the Cretaceous samples, isotopic compositions of n-alkanes are covariant with those of total organic carbon, while delta values for pristane and phytane are covariant with those of porphyrins. In this unit representing an open marine environment, the preserved acyclic polyisoprenoids apparently derive mainly from primary material, while the extractable, n-alkanes derive mainly from lower levels of the food chain. In the Messel Shale, isotopic compositions of individual biomarkers range from -20.9 to -73.4% vs PDB. Isotopic compositions of specific compounds can be interpreted in terms of origin from methylotrophic, chemautotrophic, and chemolithotrophic microorganisms as well as from primary producers that lived in the water column and sediments of this ancient lake.

Characterization and differentiation of human embryonic stem cells.

PubMed

Carpenter, M K; Rosler, E; Rao, M S

2003-01-01

Cell replacement therapies have been limited by the availability of sufficient quantities of cells for transplantation. Human ES (hES) cell lines have recently been generated by several laboratories. When maintained for over 1 year in vitro, they remain karyotypically and phenotypically stable and may therefore provide an excellent source material for cell therapies. Currently, data is available for 26 hES cell lines. Although limited characterization has been performed on most of these lines, there are remarkable similarities in expression of markers. hES cell lines derived in different laboratories show similar expression profiles of surface markers, including SSEA-4, Tra-1-60, and Tra-1-81. In addition, markers associated with pluripotent cells such as OCT-4 are expressed at in all cell lines tested. These cells express high levels of telomerase and appear to have indefinite growth potential. The generation of the large quantities of cells necessary for cell replacement therapies will require a cell population which is stable over long term culture. We have characterized the properties of multiple hES cell lines that have been maintained in culture for extended periods. Quantitative analyses demonstrate that all of the cell lines examined show consistent marker expression and retain a normal karyotype after long-term culture. hES cells have been differentiated into the derivatives of all three germ layers. Specifically this includes cardiomyocytes, neural cells, hepatocyte-like cells, endothelial cells and hematopoietic progenitor cells. These data demonstrating the karyotypic and phenotypic stability of hES cells and their extensive differentiative capacity indicate that they may be an appropriate source of cells for multiple regenerative medicine applications.

Data Resources for the Computer-Guided Discovery of Bioactive Natural Products.

PubMed

Chen, Ya; de Bruyn Kops, Christina; Kirchmair, Johannes

2017-09-25

Natural products from plants, animals, marine life, fungi, bacteria, and other organisms are an important resource for modern drug discovery. Their biological relevance and structural diversity make natural products good starting points for drug design. Natural product-based drug discovery can benefit greatly from computational approaches, which are a valuable precursor or supplementary method to in vitro testing. We present an overview of 25 virtual and 31 physical natural product libraries that are useful for applications in cheminformatics, in particular virtual screening. The overview includes detailed information about each library, the extent of its structural information, and the overlap between different sources of natural products. In terms of chemical structures, there is a large overlap between freely available and commercial virtual natural product libraries. Of particular interest for drug discovery is that at least ten percent of known natural products are readily purchasable and many more natural products and derivatives are available through on-demand sourcing, extraction and synthesis services. Many of the readily purchasable natural products are of small size and hence of relevance to fragment-based drug discovery. There are also an increasing number of macrocyclic natural products and derivatives becoming available for screening.

Green’s functions for a volume source in an elastic half-space

PubMed Central

Zabolotskaya, Evgenia A.; Ilinskii, Yurii A.; Hay, Todd A.; Hamilton, Mark F.

2012-01-01

Green’s functions are derived for elastic waves generated by a volume source in a homogeneous isotropic half-space. The context is sources at shallow burial depths, for which surface (Rayleigh) and bulk waves, both longitudinal and transverse, can be generated with comparable magnitudes. Two approaches are followed. First, the Green’s function is expanded with respect to eigenmodes that correspond to Rayleigh waves. While bulk waves are thus ignored, this approximation is valid on the surface far from the source, where the Rayleigh wave modes dominate. The second approach employs an angular spectrum that accounts for the bulk waves and yields a solution that may be separated into two terms. One is associated with bulk waves, the other with Rayleigh waves. The latter is proved to be identical to the Green’s function obtained following the first approach. The Green’s function obtained via angular spectrum decomposition is analyzed numerically in the time domain for different burial depths and distances to the receiver, and for parameters relevant to seismo-acoustic detection of land mines and other buried objects. PMID:22423682

Analysis and Design of Symmetrical Capacitor Diode Voltage Multiplier Driven by LCL-T Resonant Converter

NASA Astrophysics Data System (ADS)

Malviya, Devesh; Borage, Mangesh Balkrishna; Tiwari, Sunil

2017-12-01

This paper investigates the possibility of application of Resonant Immittance Converters (RICs) as a current source for the current-fed symmetrical Capacitor-Diode Voltage Multiplier (CDVM) with LCL-T Resonant Converter (RC) as an example. Firstly, detailed characterization of the current-fed symmetrical CDVM is carried out using repeated simulations followed by the normalization of the simulation results in order to derive the closed-form curve fit equations to predict the operating modes, output voltage and ripple in terms of operating parameters. RICs, due to their ability to convert voltage source into a current source, become a possible candidate for the realization of current source for the current-fed symmetrical CDVM. Detailed analysis, optimization and design of LCL-T RC with CDVM is performed in this paper. A step by step design procedure for the design of CDVM and the converter is proposed. A 5-stage prototype symmetrical CDVM driven by LCL-T RC to produce 2.5 kV, 50 mA dc output voltage is designed, built and tested to validate the findings of the analysis and simulation.

X-ray observations of the supernova remnant MSH 11-54

NASA Technical Reports Server (NTRS)

Agrawal, P. C.; Riegler, G. R.

1980-01-01

Soft X-ray observations of the X-ray source H1122-59 in the 0.4-2 keV band made with the low-energy detector 1 of the HEAO A-2 experiment are described. Based on positional coincidence, the source is identified with the supernova remnant MSH-11-54, thus confirming the report of Share et al. (1980). The object is a bright source in the 0.4-2 keV band with an X-ray flux of 9 x 10 to the -11th ergs/sq cm s near the earth. The measured source spectrum implies a plasma temperature of 4 million K and X-ray luminosity in the 0.4-2 keV band of 10 to the 37th ergs/s using a distance of 10 kpc for MSH 11-54. The X-ray observations, interpreted in terms of an adiabatic shock wave model, give a shock velocity of about 560 km/s and a supernova age of about 2300 yr, in good agreement with the age derived from the radio observations.

Pectin, Hemicellulose, or Lignin? Impact of the Biowaste Source on the Performance of Hard Carbons for Sodium-Ion Batteries.

PubMed

Dou, Xinwei; Hasa, Ivana; Hekmatfar, Maral; Diemant, Thomas; Behm, R Jürgen; Buchholz, Daniel; Passerini, Stefano

2017-06-22

Hard carbons are currently the most widely used negative electrode materials in Na-ion batteries. This is due to their promising electrochemical performance with capacities of 200-300 mAh g -1 and stable long-term cycling. However, an abundant and cheap carbon source is necessary in order to comply with the low-cost philosophy of Na-ion technology. Many biological or waste materials have been used to synthesize hard carbons but the impact of the precursors on the final properties of the anode material is not fully understood. In this study the impact of the biomass source on the structural and electrochemical properties of hard carbons is unraveled by using different, representative types of biomass as examples. The systematic structural and electrochemical investigation of hard carbons derived from different sources-namely corncobs, peanut shells, and waste apples, which are representative of hemicellulose-, lignin- and pectin-rich biomass, respectively-enables understanding and interlinking of the structural and electrochemical properties. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

A structured approach to recording AIDS-defining illnesses in Kenya: A SNOMED CT based solution

PubMed Central

Oluoch, Tom; de Keizer, Nicolette; Langat, Patrick; Alaska, Irene; Ochieng, Kenneth; Okeyo, Nicky; Kwaro, Daniel; Cornet, Ronald

2016-01-01

Introduction Several studies conducted in sub-Saharan Africa (SSA) have shown that routine clinical data in HIV clinics often have errors. Lack of structured and coded documentation of diagnosis of AIDS defining illnesses (ADIs) can compromise data quality and decisions made on clinical care. Methods We used a structured framework to derive a reference set of concepts and terms used to describe ADIs. The four sources used were: (i) CDC/Accenture list of opportunistic infections, (ii) SNOMED Clinical Terms (SNOMED CT), (iii) Focus Group Discussion (FGD) among clinicians and nurses attending to patients at a referral provincial hospital in western Kenya, and (iv) chart abstraction from the Maternal Child Health (MCH) and HIV clinics at the same hospital. Using the January 2014 release of SNOMED CT, concepts were retrieved that matched terms abstracted from approach iii & iv, and the content coverage assessed. Post-coordination matching was applied when needed. Results The final reference set had 1054 unique ADI concepts which were described by 1860 unique terms. Content coverage of SNOMED CT was high (99.9% with pre-coordinated concepts; 100% with post-coordination). The resulting reference set for ADIs was implemented as the interface terminology on OpenMRS data entry forms. Conclusion Different sources demonstrate complementarity in the collection of concepts and terms for an interface terminology. SNOMED CT provides a high coverage in the domain of ADIs. Further work is needed to evaluate the effect of the interface terminology on data quality and quality of care. PMID:26184057

Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?

PubMed

Precious, Sophie V; Zietlow, Rike; Dunnett, Stephen B; Kelly, Claire M; Rosser, Anne E

2017-06-01

Huntington's disease (HD) is a neurodegenerative disease that offers an excellent paradigm for cell replacement therapy because of the associated relatively focal cell loss in the striatum. The predominant cells lost in this condition are striatal medium spiny neurons (MSNs). Transplantation of developing MSNs taken from the fetal brain has provided proof of concept that donor MSNs can survive, integrate and bring about a degree of functional recovery in both pre-clinical studies and in a limited number of clinical trials. The scarcity of human fetal tissue, and the logistics of coordinating collection and dissection of tissue with neurosurgical procedures makes the use of fetal tissue for this purpose both complex and limiting. Alternative donor cell sources which are expandable in culture prior to transplantation are currently being sought. Two potential donor cell sources which have received most attention recently are embryonic stem (ES) cells and adult induced pluripotent stem (iPS) cells, both of which can be directed to MSN-like fates, although achieving a genuine MSN fate has proven to be difficult. All potential donor sources have challenges in terms of their clinical application for regenerative medicine, and thus it is important to continue exploring a wide variety of expandable cells. In this review we discuss two less well-reported potential donor cell sources; embryonic germ (EG) cells and fetal neural precursors (FNPs), both are which are fetal-derived and have some properties that could make them useful for regenerative medicine applications. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Sources of Hematopoietic Stem and Progenitor Cells and Methods to Optimize Yields for Clinical Cell Therapy.

PubMed

Panch, Sandhya R; Szymanski, James; Savani, Bipin N; Stroncek, David F

2017-08-01

Bone marrow (BM) aspirates, mobilized peripheral blood, and umbilical cord blood (UCB) have developed as graft sources for hematopoietic stem and progenitor cells (HSPCs) for stem cell transplantation and other cellular therapeutics. Individualized techniques are necessary to enhance graft HSPC yields and cell quality from each graft source. BM aspirates yield adequate CD34 + cells but can result in relative delays in engraftment. Granulocyte colony-stimulating factor (G-CSF)-primed BM HSPCs may facilitate faster engraftment while minimizing graft-versus-host disease in certain patient subsets. The levels of circulating HSPCs are enhanced using mobilizing agents, such as G-CSF and/or plerixafor, which act via the stromal cell-derived factor 1/C-X-C chemokine receptor type 4 axis. Alternate niche pathway mediators, including very late antigen-4/vascular cell adhesion molecule-1, heparan sulfate proteoglycans, parathyroid hormone, and coagulation cascade intermediates, may offer promising alternatives for graft enhancement. UCB grafts have been expanded ex vivo with cytokines, notch-ligand, or mesenchymal stromal cells, and most studies demonstrated greater quantities of CD34 + cells ex vivo and improved short-term engraftment. No significant changes were observed in long-term repopulating potential or in patient survival. Early phase clinical trials using nicotinamide and StemReginin1 may offer improved short- and long-term repopulating ability. Breakthroughs in genome editing and stem cell reprogramming technologies may hasten the generation of pooled, third-party HSPC grafts. This review elucidates past, present, and potential future approaches to HSPC graft optimization. Published by Elsevier Inc.

Integrating data types to enhance shoreline change assessments

NASA Astrophysics Data System (ADS)

Long, J.; Henderson, R.; Plant, N. G.; Nelson, P. R.

2016-12-01

Shorelines represent the variable boundary between terrestrial and marine environments. Assessment of geographic and temporal variability in shoreline position and related variability in shoreline change rates are an important part of studies and applications related to impacts from sea-level rise and storms. The results from these assessments are used to quantify future ecosystem services and coastal resilience and guide selection of appropriate coastal restoration and protection designs. But existing assessments typically fail to incorporate all available shoreline observations because they are derived from multiple data types and have different or unknown biases and uncertainties. Shoreline-change research and assessments often focus on either the long-term trajectory using sparse data over multiple decades or shorter-term evolution using data collected more frequently but over a shorter period of time. The combination of data collected with significantly different temporal resolution is not often considered. Also, differences in the definition of the shoreline metric itself can occur, whether using a single or multiple data source(s), due to variation the signal being detected in the data (e.g. instantaneous land/water interface, swash zone, wrack line, or topographic contours). Previous studies have not explored whether more robust shoreline change assessments are possible if all available data are utilized and all uncertainties are considered. In this study, we test the hypothesis that incorporating all available shoreline data will lead to both improved historical assessments and enhance the predictive capability of shoreline-change forecasts. Using over 250 observations of shoreline position at Dauphin Island, Alabama over the last century, we compare shoreline-change rates derived from individual data sources (airborne lidar, satellite, aerial photographs) with an assessment using the combination of all available data. Biases or simple uncertainties in the shoreline metric from different data types and varying temporal/spatial resolution of the data are examined. As part of this test, we also demonstrate application of data assimilation techniques to predict shoreline position by accurately including the uncertainty in each type of data.

Provenance history of detrital diamond deposits, West Coast of Namaqualand, South Africa

NASA Astrophysics Data System (ADS)

Phillips, David; Harris, Jeffrey W.; de Wit, Michiel C. J.; Matchan, Erin L.

2018-05-01

The West Coast of Namaqualand in South Africa hosts extensive detrital diamond deposits, but considerable debate exists as to the provenance of these diamonds. Some researchers have suggested derivation of the diamonds from Cretaceous-Jurassic kimberlites (also termed Group I kimberlites) and orangeites (also termed Group II kimberlites) located on the Kaapvaal Craton. However, others favour erosion of diamonds from the ca.300 Ma Dwyka Group sediments, with older, pre-Karoo kimberlites being the original source(s). Previous work has demonstrated that 40Ar/39Ar analyses of clinopyroxene inclusions, extracted from diamonds, yield ages approaching the time(s) of source kimberlite emplacement, which can be used to constrain the provenance of placer diamond deposits. In the current study, 40Ar/39Ar analyses were conducted on clinopyroxene inclusions from two similar batches of Namaqualand detrital diamonds, yielding (maximum) ages ranging from 117.5 ± 43.6 Ma to 3684 ± 191 Ma (2σ) and 120.6 ± 15.4 Ma to 688.8 ± 4.9 Ma (2σ), respectively. The vast majority of inclusions (88%) produced ages younger than 500 Ma, indicating that most Namaqualand diamonds originated from Cretaceous-Jurassic kimberlites/orangeites, with few, if any, derived from the Dwyka tillites. The provenance of the Namaqualand diamonds from ca.115-200 Ma orangeites is consistent with Late Cretaceous paleo-drainage reconstructions, as these localities could have been sampled by the `paleo-Karoo' River and transported to the West Coast via an outlet close to the current Olifants River mouth. At ca.90 Ma, this drainage system appears to have been captured by the `paleo-Kalahari' River, a precursor to the modern Orange River system. This latter drainage is considered to have transported diamonds eroded from both ca.80-90 Ma kimberlites and ca.115-200 Ma orangeites to the West Coast, which were subsequently reworked along the Namibian coast, forming additional placer deposits.

Evolution of air pollution source contributions over one decade, derived by PM10 and PM2.5 source apportionment in two metropolitan urban areas in Greece

NASA Astrophysics Data System (ADS)

Diapouli, E.; Manousakas, M.; Vratolis, S.; Vasilatou, V.; Maggos, Th; Saraga, D.; Grigoratos, Th; Argyropoulos, G.; Voutsa, D.; Samara, C.; Eleftheriadis, K.

2017-09-01

Metropolitan Urban areas in Greece have been known to suffer from poor air quality, due to variety of emission sources, topography and climatic conditions favouring the accumulation of pollution. While a number of control measures have been implemented since the 1990s, resulting in reductions of atmospheric pollution and changes in emission source contributions, the financial crisis which started in 2009 has significantly altered this picture. The present study is the first effort to assess the contribution of emission sources to PM10 and PM2.5 concentration levels and their long-term variability (over 5-10 years), in the two largest metropolitan urban areas in Greece (Athens and Thessaloniki). Intensive measurement campaigns were conducted during 2011-2012 at suburban, urban background and urban traffic sites in these two cities. In addition, available datasets from previous measurements in Athens and Thessaloniki were used in order to assess the long-term variability of concentrations and sources. Chemical composition analysis of the 2011-2012 samples showed that carbonaceous matter was the most abundant component for both PM size fractions. Significant increase of carbonaceous particle concentrations and of OC/EC ratio during the cold period, especially in the residential urban background sites, pointed towards domestic heating and more particularly wood (biomass) burning as a significant source. PMF analysis further supported this finding. Biomass burning was the largest contributing source at the two urban background sites (with mean contributions for the two size fractions in the range of 24-46%). Secondary aerosol formation (sulphate, nitrate & organics) was also a major contributing source for both size fractions at the suburban and urban background sites. At the urban traffic site, vehicular traffic (exhaust and non-exhaust emissions) was the source with the highest contributions, accounting for 44% of PM10 and 37% of PM2.5, respectively. The long-term variability of emission sources in the two cities (over 5-10 years), assessed through a harmonized application of the PMF technique on recent and past year data, clearly demonstrates the effective reduction in emissions during the last decade due to control measures and technological development; however, it also reflects the effects of the financial crisis in Greece during these years, which has led to decreased economic activities and the adoption of more polluting practices by the local population in an effort to reduce living costs.

Refining Binary Pulsar B1913+16's Gravitational Wave Test via a VLBI Parallax Measurement

NASA Astrophysics Data System (ADS)

Weisberg, Joel; Deller, Adam; Chatterjee, Shami; Nice, David

2018-01-01

The orbital decay of binary pulsar B1913+16 provided the first evidence of gravitational waves as predicted by General Relativity, and ruled out numerous previously viable alternative gravitational theories (e.g., Taylor & Weisberg, APJ, 253, 908, 1982). The gravitational wave emission and resulting orbital decay manifest themselves as an orbital period derivative. Subsequent observations (e.g., Weisberg and Huang 2016, APJ, 829, 55) have greatly refined the precision of the orbital period derivative measurement. The accuracy of the experiment is currently limited by our knowledge of the relative galactic accelerations of the binary and solar system barycenters, which make another contribution to the observed orbital period derivative. The magnitude of these accelerations depend on various galactic constants and on the pulsar distance.As our knowledge of the Galaxy and its motions has improved, the pulsar's distance has become the largest remaining source of uncertainty in the experiment.Therefore, we conducted a series of astrometric measurements of PSR B1913+16 with the Very Long Baseline Array. We report the pulsar parallax and distance derived from these measurements, and use them to correct our observed orbital period derivative for the above galactic acceleration term, thereby providing a more accurate test of gravitational radiation emission from the system.

Deriving Color-Color Transformations for VRI Photometry

NASA Astrophysics Data System (ADS)

Taylor, B. J.; Joner, M. D.

2006-12-01

In this paper, transformations between Cousins R-I and other indices are considered. New transformations to Cousins V-R and Johnson V-K are derived, a published transformation involving T1-T2 on the Washington system is rederived, and the basis for a transformation involving b-y is considered. In addition, a statistically rigorous procedure for deriving such transformations is presented and discussed in detail. Highlights of the discussion include (1) the need for statistical analysis when least-squares relations are determined and interpreted, (2) the permitted forms and best forms for such relations, (3) the essential role played by accidental errors, (4) the decision process for selecting terms to appear in the relations, (5) the use of plots of residuals, (6) detection of influential data, (7) a protocol for assessing systematic effects from absorption features and other sources, (8) the reasons for avoiding extrapolation of the relations, (9) a protocol for ensuring uniformity in data used to determine the relations, and (10) the derivation and testing of the accidental errors of those data. To put the last of these subjects in perspective, it is shown that rms errors for VRI photometry have been as small as 6 mmag for more than three decades and that standard errors for quantities derived from such photometry can be as small as 1 mmag or less.

Parameterized source term in the diffusion approximation for enhanced near-field modeling of collimated light

NASA Astrophysics Data System (ADS)

Jia, Mengyu; Wang, Shuang; Chen, Xueying; Gao, Feng; Zhao, Huijuan

2016-03-01

Most analytical methods for describing light propagation in turbid medium exhibit low effectiveness in the near-field of a collimated source. Motivated by the Charge Simulation Method in electromagnetic theory as well as the established discrete source based modeling, we have reported on an improved explicit model, referred to as "Virtual Source" (VS) diffuse approximation (DA), to inherit the mathematical simplicity of the DA while considerably extend its validity in modeling the near-field photon migration in low-albedo medium. In this model, the collimated light in the standard DA is analogously approximated as multiple isotropic point sources (VS) distributed along the incident direction. For performance enhancement, a fitting procedure between the calculated and realistic reflectances is adopted in the nearfield to optimize the VS parameters (intensities and locations). To be practically applicable, an explicit 2VS-DA model is established based on close-form derivations of the VS parameters for the typical ranges of the optical parameters. The proposed VS-DA model is validated by comparing with the Monte Carlo simulations, and further introduced in the image reconstruction of the Laminar Optical Tomography system.

Cancellation of spurious arrivals in Green's function extraction and the generalized optical theorem

USGS Publications Warehouse

Snieder, R.; Van Wijk, K.; Haney, M.; Calvert, R.

2008-01-01

The extraction of the Green's function by cross correlation of waves recorded at two receivers nowadays finds much application. We show that for an arbitrary small scatterer, the cross terms of scattered waves give an unphysical wave with an arrival time that is independent of the source position. This constitutes an apparent inconsistency because theory predicts that such spurious arrivals do not arise, after integration over a complete source aperture. This puzzling inconsistency can be resolved for an arbitrary scatterer by integrating the contribution of all sources in the stationary phase approximation to show that the stationary phase contributions to the source integral cancel the spurious arrival by virtue of the generalized optical theorem. This work constitutes an alternative derivation of this theorem. When the source aperture is incomplete, the spurious arrival is not canceled and could be misinterpreted to be part of the Green's function. We give an example of how spurious arrivals provide information about the medium complementary to that given by the direct and scattered waves; the spurious waves can thus potentially be used to better constrain the medium. ?? 2008 The American Physical Society.

Terminology for Neuroscience Data Discovery: Multi-tree Syntax and Investigator-Derived Semantics

PubMed Central

Goldberg, David H.; Grafstein, Bernice; Robert, Adrian; Gardner, Esther P.

2009-01-01

The Neuroscience Information Framework (NIF), developed for the NIH Blueprint for Neuroscience Research and available at http://nif.nih.gov and http://neurogateway.org, is built upon a set of coordinated terminology components enabling data and web-resource description and selection. Core NIF terminologies use a straightforward syntax designed for ease of use and for navigation by familiar web interfaces, and readily exportable to aid development of relational-model databases for neuroscience data sharing. Datasets, data analysis tools, web resources, and other entities are characterized by multiple descriptors, each addressing core concepts, including data type, acquisition technique, neuroanatomy, and cell class. Terms for each concept are organized in a tree structure, providing is-a and has-a relations. Broad general terms near each root span the category or concept and spawn more detailed entries for specificity. Related but distinct concepts (e.g., brain area and depth) are specified by separate trees, for easier navigation than would be required by graph representation. Semantics enabling NIF data discovery were selected at one or more workshops by investigators expert in particular systems (vision, olfaction, behavioral neuroscience, neurodevelopment), brain areas (cerebellum, thalamus, hippocampus), preparations (molluscs, fly), diseases (neurodegenerative disease), or techniques (microscopy, computation and modeling, neurogenetics). Workshop-derived integrated term lists are available Open Source at http://brainml.org; a complete list of participants is at http://brainml.org/workshops. PMID:18958630

EVALUATING SOIL EROSION PARAMETER ESTIMATES FROM DIFFERENT DATA SOURCES

EPA Science Inventory

Topographic factors and soil loss estimates that were derived from thee data sources (STATSGO, 30-m DEM, and 3-arc second DEM) were compared. Slope magnitudes derived from the three data sources were consistently different. Slopes from the DEMs tended to provide a flattened sur...

A study of the prediction of cruise noise and laminar flow control noise criteria for subsonic air transports

NASA Technical Reports Server (NTRS)

Swift, G.; Mungur, P.

1979-01-01

General procedures for the prediction of component noise levels incident upon airframe surfaces during cruise are developed. Contributing noise sources are those associated with the propulsion system, the airframe and the laminar flow control (LFC) system. Transformation procedures from the best prediction base of each noise source to the transonic cruise condition are established. Two approaches to LFC/acoustic criteria are developed. The first is a semi-empirical extension of the X-21 LFC/acoustic criteria to include sensitivity to the spectrum and directionality of the sound field. In the second, the more fundamental problem of how sound excites boundary layer disturbances is analyzed by deriving and solving an inhomogeneous Orr-Sommerfeld equation in which the source terms are proportional to the production and dissipation of sound induced fluctuating vorticity. Numerical solutions are obtained and compared with corresponding measurements. Recommendations are made to improve and validate both the cruise noise prediction methods and the LFC/acoustic criteria.

Cramer-Rao bound analysis of wideband source localization and DOA estimation

NASA Astrophysics Data System (ADS)

Yip, Lean; Chen, Joe C.; Hudson, Ralph E.; Yao, Kung

2002-12-01

In this paper, we derive the Cramér-Rao Bound (CRB) for wideband source localization and DOA estimation. The resulting CRB formula can be decomposed into two terms: one that depends on the signal characteristic and one that depends on the array geometry. For a uniformly spaced circular array (UCA), a concise analytical form of the CRB can be given by using some algebraic approximation. We further define a DOA beamwidth based on the resulting CRB formula. The DOA beamwidth can be used to design the sampling angular spacing for the Maximum-likelihood (ML) algorithm. For a randomly distributed array, we use an elliptical model to determine the largest and smallest effective beamwidth. The effective beamwidth and the CRB analysis of source localization allow us to design an efficient algorithm for the ML estimator. Finally, our simulation results of the Approximated Maximum Likelihood (AML) algorithm are demonstrated to match well to the CRB analysis at high SNR.

Assessment of the instantaneous unit hydrograph derived from the theory of topologically random networks

USGS Publications Warehouse

Karlinger, M.R.; Troutman, B.M.

1985-01-01

An instantaneous unit hydrograph (iuh) based on the theory of topologically random networks (topological iuh) is evaluated in terms of sets of basin characteristics and hydraulic parameters. Hydrographs were computed using two linear routing methods for each of two drainage basins in the southeastern United States and are the basis of comparison for the topological iuh's. Elements in the sets of basin characteristics for the topological iuh's are the number of first-order streams only, (N), or the nuber of sources together with the number of channel links in the topological diameter (N, D); the hydraulic parameters are values of the celerity and diffusivity constant. Sensitivity analyses indicate that the mean celerity of the internal links in the network is the critical hydraulic parameter for determining the shape of the topological iuh, while the diffusivity constant has minimal effect on the topological iuh. Asymptotic results (source-only) indicate the number of sources need not be large to approximate the topological iuh with the Weibull probability density function.

Molecular Anions in Protostars, Prestellar Cores and Dark Clouds

NASA Technical Reports Server (NTRS)

Cordiner, Martin; Charnley, Steven; Buckle, Jane; Wash, Catherine; Millar, Tom

2011-01-01

From our recent survey work using the Green Bank Telescope, microwave emission lines from the hydrocarbon anion C6H(-) and its parent neutral C6H have been detected in six new sources. Using HC3N = 10(exp -9) emission maps, we targeted the most carbon-chain-rich sources for our anion survey, which included the low-mass Class 0 protostar L1251A-IRS3, the prestellar cores L1389-SMM1 and L1512, and the interstellar clouds Ll172A, TMC-1C and L1495B. Derived [C6H(-)]/[C6H] anion-to-neutral ratios are approximately 1-10. The greatest C6H(-) column densities are found in the quiescent clouds TMC-1C and L1495B, but the anion-to-neutral ratios are greatest in the prestellar cores and protostars. These results are interpreted in terms of the physical and chemical properties of the sources, and the implications for molecular cloud chemistry are discussed.

The Effect of Systematic Error in Forced Oscillation Testing

NASA Technical Reports Server (NTRS)

Williams, Brianne Y.; Landman, Drew; Flory, Isaac L., IV; Murphy, Patrick C.

2012-01-01

One of the fundamental problems in flight dynamics is the formulation of aerodynamic forces and moments acting on an aircraft in arbitrary motion. Classically, conventional stability derivatives are used for the representation of aerodynamic loads in the aircraft equations of motion. However, for modern aircraft with highly nonlinear and unsteady aerodynamic characteristics undergoing maneuvers at high angle of attack and/or angular rates the conventional stability derivative model is no longer valid. Attempts to formulate aerodynamic model equations with unsteady terms are based on several different wind tunnel techniques: for example, captive, wind tunnel single degree-of-freedom, and wind tunnel free-flying techniques. One of the most common techniques is forced oscillation testing. However, the forced oscillation testing method does not address the systematic and systematic correlation errors from the test apparatus that cause inconsistencies in the measured oscillatory stability derivatives. The primary objective of this study is to identify the possible sources and magnitude of systematic error in representative dynamic test apparatuses. Sensitivities of the longitudinal stability derivatives to systematic errors are computed, using a high fidelity simulation of a forced oscillation test rig, and assessed using both Design of Experiments and Monte Carlo methods.

Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data.

PubMed

Gamie, Zakareya; MacFarlane, Robert J; Tomkinson, Alicia; Moniakis, Alexandros; Tran, Gui Tong; Gamie, Yehya; Mantalaris, Athanasios; Tsiridis, Eleftherios

2014-11-01

Mesenchymal stem cells (MSCs) can be obtained from a wide variety of tissues for bone tissue engineering such as bone marrow, adipose, birth-associated, peripheral blood, periosteum, dental and muscle. MSCs from human fetal bone marrow and embryonic stem cells (ESCs) are also promising cell sources. In vitro, in vivo and clinical evidence was collected using MEDLINE® (1950 to January 2014), EMBASE (1980 to January 2014) and Google Scholar (1980 to January 2014) databases. Enhanced results have been found when combining bone marrow-derived mesenchymal stem cells (BMMSCs) with recently developed scaffolds such as glass ceramics and starch-based polymeric scaffolds. Preclinical studies investigating adipose tissue-derived stem cells and umbilical cord tissue-derived stem cells suggest that they are likely to become promising alternatives. Stem cells derived from periosteum and dental tissues such as the periodontal ligament have an osteogenic potential similar to BMMSCs. Stem cells from human fetal bone marrow have demonstrated superior proliferation and osteogenic differentiation than perinatal and postnatal tissues. Despite ethical concerns and potential for teratoma formation, developments have also been made for the use of ESCs in terms of culture and ideal scaffold.

Therapeutic charm of quercetin and its derivatives: a review of research and patents.

PubMed

Sharma, Ajay; Kashyap, Dharambir; Sak, Katrin; Tuli, Hardeep Singh; Sharma, Anil K

2018-01-01

Bioactive polyphenolic compounds derived from plants are being utilized for prevention of various chronic diseases including cancer and cardiovascular disorders. Quercetin, a potential poly-phenolic flavonol, found in onions, apples and berries, has been implicated against cancer proliferation, chronic inflammation and various other oxidative manifestations. Evidences suggested that quercetin negatively regulates the numerous crucial signaling pathways associated with life-threatening diseases. Major signaling pathways including NF-κB, MAPK, PI3K-AKT and mTOR are found to be regulated by quercetin. In addition, several patents have reported recently on quercetin derivatives describing wide therapeutic applications such as anticancer/antiproliferatory, antioxidative/antiaging, antiviral, anti-inflammatory, cardioprotective. Present review emphasizes the chemistry and sources of quercetin followed by description of its broad-spectrum therapeutic potential along with proposed mechanisms of action. Furthermore, this review also highlights the important modifications in the basic chemical structure of quercetin in terms of published patents. Insolubility of the bioactive compounds restricts their medicinal importance which could be overcome by modifications in the chemical structure of so-called derivatives. Most of the patents deal with the modifications in chemical structure of quercetin mainly at hydroxyl groups and C-6 and C-7 positions.

In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase

PubMed Central

Gori, Jennifer L.; Tian, Xinghui; Swanson, Debra; Gunther, Roland; Shultz, Leonard D.; McIvor, R. Scott; Kaufman, Dan S.

2009-01-01

SUMMARY Human embryonic stem cells (hESCs) provide a novel source of hematopoietic and other cell populations suitable for gene therapy applications. Preclinical studies to evaluate engraftment of hESC-derived hematopoietic cells transplanted into immunodeficient mice demonstrate only limited repopulation. Expression of a drug resistance gene, such as Tyr22-dihydrofolate reductase (Tyr22-DHFR), coupled to methotrexate (MTX) chemotherapy has the potential to selectively increase engraftment of gene-modified hESC-derived cells in mouse xenografts. Here, we describe the generation of Tyr22-DHFR – GFP expressing hESCs that maintain pluripotency, produce teratomas and can differentiate into MTXr-hemato-endothelial cells. We demonstrate that MTX administered to nonobese diabetic/severe combined immunodeficient/IL-2Rγcnull (NSG) mice after injection of Tyr22-DHFR-derived cells significantly increases human CD34+ and CD45+ cell engraftment in the bone marrow (BM) and peripheral blood of transplanted MTX-treated mice. These results demonstrate that MTX treatment supports selective, long-term engraftment of Tyr22-DHFR-cells in vivo, and provides a novel approach for combined human cell and gene therapy. PMID:19829316

Sources and ages of fine-grained sediment to streams using fallout radionuclides in the Midwestern United States

USGS Publications Warehouse

Gellis, Allen; Fuller, Christopher C.; Van Metre, Peter C.

2017-01-01

Fallout radionuclides, 7Be and 210Pbex, sampled in bed sediment for 99 watersheds in the Midwestern region of the United States and in 15 samples of suspended sediment from 3 of these watersheds were used to partition upland from channel sources and to estimate the age or the time since the surface-derived portion of sediment was on the land surface (0–∼1 year). Channel sources dominate: 78 of the 99 bed material sites (79%) have >50% channel-derived sediment, and 9 of the 15 suspended-sediment samples (60%) have >50% channel-derived sediment. 7Be was detected in 82 bed sediment samples and all 15 suspended-sediment samples. The surface-derived portion of 54 of the 80 (68%) streams with detectable 7Be and 210Pbex were ≤ 100 days old and the surface-derived portion of all suspended-sediment samples were ≤ 100 days old, indicating that surface-derived fine-grained sediment moves rapidly though these systems. The concentrations of two hydrophobic pesticides–DDE and bifenthrin–are correlated with the proportion of surface-derived sediment, indicating a link between geomorphic processes and particle-associated contaminants in streams. Urban areas had the highest pesticide concentrations and the largest percentage of surface-derived sediment. Although the percentage of surface-derived sediment is less than channel sources at most of the study sites, the relatively young age of the surface-derived sediment might indicate that management actions to reduce sediment contamination where the land surface is an important source could have noticeable effects.

The concentration-discharge slope as a tool for water quality management.

PubMed

Bieroza, M Z; Heathwaite, A L; Bechmann, M; Kyllmar, K; Jordan, P

2018-07-15

Recent technological breakthroughs of optical sensors and analysers have enabled matching the water quality measurement interval to the time scales of stream flow changes and led to an improved understanding of spatially and temporally heterogeneous sources and delivery pathways for many solutes and particulates. This new ability to match the chemograph with the hydrograph has promoted renewed interest in the concentration-discharge (c-q) relationship and its value in characterizing catchment storage, time lags and legacy effects for both weathering products and anthropogenic pollutants. In this paper we evaluated the stream c-q relationships for a number of water quality determinands (phosphorus, suspended sediments, nitrogen) in intensively managed agricultural catchments based on both high-frequency (sub-hourly) and long-term low-frequency (fortnightly-monthly) routine monitoring data. We used resampled high-frequency data to test the uncertainty in water quality parameters (e.g. mean, 95th percentile and load) derived from low-frequency sub-datasets. We showed that the uncertainty in water quality parameters increases with reduced sampling frequency as a function of the c-q slope. We also showed that different sources and delivery pathways control c-q relationship for different solutes and particulates. Secondly, we evaluated the variation in c-q slopes derived from the long-term low-frequency data for different determinands and catchments and showed strong chemostatic behaviour for phosphorus and nitrogen due to saturation and agricultural legacy effects. The c-q slope analysis can provide an effective tool to evaluate the current monitoring networks and the effectiveness of water management interventions. This research highlights how improved understanding of solute and particulate dynamics obtained with optical sensors and analysers can be used to understand patterns in long-term water quality time series, reduce the uncertainty in the monitoring data and to manage eutrophication in agricultural catchments. Copyright © 2018 Elsevier B.V. All rights reserved.

Nimbus-7 Earth radiation budget calibration history. Part 2: The Earth flux channels

NASA Technical Reports Server (NTRS)

Kyle, H. Lee; Hucek, Douglas Richard R.; Ardanuy, Philip E.; Hickey, John R.; Maschhoff, Robert H.; Penn, Lanning M.; Groveman, Brian S.; Vallette, Brenda J.

1994-01-01

Nine years (November 1978 to October 1987) of Nimbus-7 Earth radiation budget (ERB) products have shown that the global annual mean emitted longwave, absorbed shortwave, and net radiation were constant to within about + 0.5 W/sq m. Further, most of the small annual variations in the emitted longwave have been shown to be real. To obtain this measurement accuracy, the wide-field-of-view (WFOV) Earth-viewing channels 12 (0.2 to over 50 micrometers), 13 (0.2 to 3.8 micrometers), and 14 (0.7 to 2.8 micrometers) have been characterized in their satellite environment to account for signal variations not considered in the prelaunch calibration equations. Calibration adjustments have been derived for (1) extraterrestrial radiation incident on the detectors, (2) long-term degradation of the sensors, and (3) thermal perturbations within the ERB instrument. The first item is important in all the channels; the second, mainly in channels 13 and 14, and the third, only in channels 13 and 14. The Sun is used as a stable calibration source to monitor the long-term degradation of the various channels. Channel 12, which is reasonably stable to both thermal perturbations and sensor degradation, is used as a reference and calibration transfer agent for the drifting sensitivities of the filtered channels 13 and 14. Redundant calibration procedures were utilized. Laboratory studies complemented analyses of the satellite data. Two nearly independent models were derived to account for the thermal perturbations in channels 13 and 14. The global annual mean terrestrial shortwave and longwave signals proved stable enough to act as secondary calibration sources. Instantaneous measurements may still, at times, be in error by as much as a few Wm(exp -2), but the long-term averages are stable to within a fraction of a Wm(exp -2).

Mesenchymal stem cells from the Wharton’s jelly of umbilical cord segments provide stromal support for the maintenance of cord blood hematopoietic stem cells during long-term ex vivo culture

PubMed Central

Bakhshi, Tiki; Zabriskie, Ryan C.; Bodie, Shamanique; Kidd, Shannon; Ramin, Susan; Paganessi, Laura A.; Gregory, Stephanie A.; Fung, Henry C.; Christopherson, Kent W.

2012-01-01

BACKGROUND Hematopoietic stem cells (HSCs) are routinely obtained from marrow, mobilized peripheral blood, and umbilical cord blood. Mesenchymal stem cells (MSCs) are traditionally isolated from marrow. Bone marrow–derived MSCs (BM-MSCs) have previously demonstrated their ability to act as a feeder layer in support of ex vivo cord blood expansion. However, the use of BM-MSCs to support the growth, differentiation, and engraftment of cord blood may not be ideal for transplant purposes. Therefore, the potential of MSCs from a novel source, the Wharton’s jelly of umbilical cords, to act as stromal support for the long-term culture of cord blood HSC was evaluated. STUDY DESIGN AND METHODS Umbilical cord–derived MSCs (UC-MSCs) were cultured from the Wharton’s jelly of umbilical cord segments. The UC-MSCs were then profiled for expression of 12 cell surface receptors and tested for their ability to support cord blood HSCs in a long-term culture-initiating cell (LTC-IC) assay. RESULTS Upon culture, UC-MSCs express a defined set of cell surface markers (CD29, CD44, CD73, CD90, CD105, CD166, and HLA-A) and lack other markers (CD45, CD34, CD38, CD117, and HLA-DR) similar to BM-MSCs. Like BM-MSCs, UC-MSCs effectively support the growth of CD34+ cord blood cells in LTC-IC assays. CONCLUSION These data suggest the potential therapeutic application of Wharton’s jelly–derived UC-MSCs to provide stromal support structure for the long-term culture of cord blood HSCs as well as the possibility of cotransplantation of genetically identical, HLA-matched, or unmatched cord blood HSCs and UC-MSCs in the setting of HSC transplantation. PMID:18798803

Electricity generation by direct oxidation of glucose in mediatorless microbial fuel cells.

PubMed

Chaudhuri, Swades K; Lovley, Derek R

2003-10-01

Abundant energy, stored primarily in the form of carbohydrates, can be found in waste biomass from agricultural, municipal and industrial sources as well as in dedicated energy crops, such as corn and other grains. Potential strategies for deriving useful forms of energy from carbohydrates include production of ethanol and conversion to hydrogen, but these approaches face technical and economic hurdles. An alternative strategy is direct conversion of sugars to electrical power. Existing transition metal-catalyzed fuel cells cannot be used to generate electric power from carbohydrates. Alternatively, biofuel cells in which whole cells or isolated redox enzymes catalyze the oxidation of the sugar have been developed, but their applicability has been limited by several factors, including (i) the need to add electron-shuttling compounds that mediate electron transfer from the cell to the anode, (ii) incomplete oxidation of the sugars and (iii) lack of long-term stability of the fuel cells. Here we report on a novel microorganism, Rhodoferax ferrireducens, that can oxidize glucose to CO(2) and quantitatively transfer electrons to graphite electrodes without the need for an electron-shuttling mediator. Growth is supported by energy derived from the electron transfer process itself and results in stable, long-term power production.

Derivation of risk indices and analysis of variablility for the management of incidents involving the transport of nuclear materials in the Northern Seas.

PubMed

Brown, J; Hosseini, A; Karcher, M; Kauker, F; Dowdall, M; Schnur, R; Strand, P

2016-04-15

The transport of nuclear or radioactive materials and the presence of nuclear powered vessels pose risks to the Northern Seas in terms of potential impacts to man and environment as well socio-economic impacts. Management of incidents involving actual or potential releases to the marine environment are potentially difficult due to the complexity of the environment into which the release may occur and difficulties in quantifying risk to both man and environment. In order to address this, a state of the art oceanographic model was used to characterize the underlying variability for a specific radionuclide release scenario. The resultant probabilistic data were used as inputs to transfer and dose models providing an indication of potential impacts for man and environment This characterization was then employed to facilitate a rapid means of quantifying risk to man and the environment that included and addressed this variability. The radionuclide specific risk indices derived can be applied by simply multiplying the reported values by the magnitude of the source term and thereafter summing over all radionuclides to provide an indication of total risk. Copyright © 2016. Published by Elsevier Ltd.

The effect of nonlinear propagation on heating of tissue: A numerical model of diagnostic ultrasound beams

NASA Astrophysics Data System (ADS)

Cahill, Mark D.; Humphrey, Victor F.; Doody, Claire

2000-07-01

Thermal safety indices for diagnostic ultrasound beams are calculated under the assumption that the sound propagates under linear conditions. A non-axisymmetric finite difference model is used to solve the KZK equation, and so to model the beam of a diagnostic scanner in pulsed Doppler mode. Beams from both a uniform focused rectangular source and a linear array are considered. Calculations are performed in water, and in attenuating media with tissue-like characteristics. Attenuating media are found to exhibit significant nonlinear effects for finite-amplitude beams. The resulting loss of intensity by the beam is then used as the source term in a model of tissue heating to estimate the maximum temperature rises. These are compared with the thermal indices, derived from the properties of the water-propagated beams.

On the dynamic toroidal multipoles from localized electric current distributions.

PubMed

Fernandez-Corbaton, Ivan; Nanz, Stefan; Rockstuhl, Carsten

2017-08-08

We analyze the dynamic toroidal multipoles and prove that they do not have an independent physical meaning with respect to their interaction with electromagnetic waves. We analytically show how the split into electric and toroidal parts causes the appearance of non-radiative components in each of the two parts. These non-radiative components, which cancel each other when both parts are summed, preclude the separate determination of each part by means of measurements of the radiation from the source or of its coupling to external electromagnetic waves. In other words, there is no toroidal radiation or independent toroidal electromagnetic coupling. The formal meaning of the toroidal multipoles is clear in our derivations. They are the higher order terms of an expansion of the multipolar coefficients of electric parity with respect to the electromagnetic size of the source.

Endocrine and metabolic consequences due to restrictive carbohydrate diets in children with type 1 diabetes: An illustrative case series.

PubMed

de Bock, Martin; Lobley, Kristine; Anderson, Donald; Davis, Elizabeth; Donaghue, Kim; Pappas, Marcelle; Siafarikas, Aris; Cho, Yoon Hi; Jones, Timothy; Smart, Carmel

2018-02-01

Low carbohydrate diets for the management of type 1 diabetes have been popularised by social media. The promotion of a low carbohydrate diet in lay media is in contrast to published pediatric diabetes guidelines that endorse a balanced diet from a variety of foods for optimal growth and development in children with type 1 diabetes. This can be a source of conflict in clinical practice. We describe a series of 6 cases where adoption of a low carbohydrate diet in children impacted growth and cardiovascular risk factors with potential long-term sequelae. These cases support current clinical guidelines for children with diabetes that promote a diet where total energy intake is derived from balanced macronutrient sources. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

What's in a ray set: moving towards a unified ray set format

NASA Astrophysics Data System (ADS)

Muschaweck, Julius

2011-10-01

For the purpose of optical simulation, a plethora of formats exist to describe the properties of a light source. Except for the EULUMDAT and IES formats which describe sources in terms of aperture area and far field intensity, all these formats are vendor specific, and no generally accepted standard exists. Most illumination simulation software vendors use their own format for ray sets, which describe sources in terms of many rays. Some of them keep their format definition proprietary. Thus, software packages typically can read or write only their own specific format, although the actual data content is not so different. Typically, they describe origin and direction of each ray in 3D vectors, and use one more single number for magnitude, where magnitude may denote radiant flux, luminous flux (equivalently tristimulus Y), or tristimulus X and Z. Sometimes each ray also carries its wavelength, while other formats allow to specify an overall spectrum for the whole source. In addition, in at least one format, polarization properties are also included for each ray. This situation makes it inefficient and potentially error prone for light source manufacturers to provide ray data sets for their sources in many different formats. Furthermore, near field goniometer vendors again use their proprietary formats to store the source description in terms of luminance data, and offer their proprietary software to generate ray sets from this data base. Again, the plethora of ray sets make the ray set production inefficient and potentially error prone. In this paper, we propose to describe ray data sets in terms of phase space, as a step towards a standardized ray set format. It is well known that luminance and radiance can be defined as flux density in phase space: luminance is flux divided by etendue. Therefore, single rays can be thought of as center points of phase space cells, where each cell possesses its volume (i.e. etendue), its flux, and therefore its luminance. In addition, each phase space cell possesses its spectrum, and its polarization properties. We show how this approach leads to a unification of the EULUMDAT/IES, ray set and near field goniometer formats, making possible the generation of arbitrarily many additional rays by luminance interpolation. We also show how the EULUMDAT/IES and individual ray set formats can be derived from the proposed general format, making software using a possible standard format downward compatible.

Spatio-temporal modeling of chronic PM 10 exposure for the Nurses' Health Study

NASA Astrophysics Data System (ADS)

Yanosky, Jeff D.; Paciorek, Christopher J.; Schwartz, Joel; Laden, Francine; Puett, Robin; Suh, Helen H.

2008-06-01

Chronic epidemiological studies of airborne particulate matter (PM) have typically characterized the chronic PM exposures of their study populations using city- or county-wide ambient concentrations, which limit the studies to areas where nearby monitoring data are available and which ignore within-city spatial gradients in ambient PM concentrations. To provide more spatially refined and precise chronic exposure measures, we used a Geographic Information System (GIS)-based spatial smoothing model to predict monthly outdoor PM10 concentrations in the northeastern and midwestern United States. This model included monthly smooth spatial terms and smooth regression terms of GIS-derived and meteorological predictors. Using cross-validation and other pre-specified selection criteria, terms for distance to road by road class, urban land use, block group and county population density, point- and area-source PM10 emissions, elevation, wind speed, and precipitation were found to be important determinants of PM10 concentrations and were included in the final model. Final model performance was strong (cross-validation R2=0.62), with little bias (-0.4 μg m-3) and high precision (6.4 μg m-3). The final model (with monthly spatial terms) performed better than a model with seasonal spatial terms (cross-validation R2=0.54). The addition of GIS-derived and meteorological predictors improved predictive performance over spatial smoothing (cross-validation R2=0.51) or inverse distance weighted interpolation (cross-validation R2=0.29) methods alone and increased the spatial resolution of predictions. The model performed well in both rural and urban areas, across seasons, and across the entire time period. The strong model performance demonstrates its suitability as a means to estimate individual-specific chronic PM10 exposures for large populations.

The use of gravimetric data from GRACE mission in the understanding of polar motion variations

NASA Astrophysics Data System (ADS)

Seoane, L.; Nastula, J.; Bizouard, C.; Gambis, D.

2009-08-01

Tesseral coefficients C21 and S21 derived from Gravity Recovery and Climate Experiment (GRACE) observations allow to compute the mass term of the polar-motion excitation function. This independent estimation can improve the geophysical models and, in addition, determine the unmodelled phenomena. In this paper, we intend to validate the polar motion excitation derived from GRACE's last release (GRACE Release 4) computed by different institutes: GeoForschungsZentrum (GFZ), Postdam, Germany; Center for Space Research (CSR), Austin, USA; Jet Propulsion Laboratory (JPL), Pasadena, USA, and the Groupe de Recherche en Géodésie Spatiale (GRGS), Toulouse, France. For this purpose, we compare these excitations functions first to the mass term obtained from observed Earth's rotation variations free of the motion term and, second, to the mass term estimated from geophysical fluids models. We confirm the large improvement of the CSR solution, and we show that the GRGS estimate is also well correlated with the geodetic observations. Significant discrepancies exist between the solutions of each centre. The source of these differences is probably related to the data processing strategy. We also consider residuals computed after removing the geophysical models or the gravimetric solutions from the geodetic mass term. We show that the residual excitation based on models is smoother than the gravimetric data, which are still noisy. Still, they are comparable for the χ2 component. It appears that χ2 residual signals using GFZ and JPL data have less variability. Finally, for assessing the impact of the geophysical fluids models choice on our results, we checked two different oceanic excitation series. We show the significant differences in the residuals correlations, especially for the χ1 more sensitive to the oceanic signals.

Characterizing Dissolved Organic Matter (DOM) Isolated From Specific Allochthonous and Autochthonous Sources in a North-Temperate Stream Ecosystem

NASA Astrophysics Data System (ADS)

Wong, J. C.; Williams, D.

2009-05-01

Detrital energy in temperate headwater streams is mainly derived from the annual input of leaf litter from the surrounding landscape. Presumably, its decomposition and other sources of autochthonous organic matter will change dissolved organic carbon (DOC) concentrations and dissolved organic matter (DOM) quality. To investigate this, DOM was leached from two allochthonous sources: white birch (Betula papyrifera) and white cedar (Thuja occidentalis); and one autochthonous source, streambed biofilm, for a period of 7 days on 3 separate occasions in fall 2007. As a second treatment, microorganisms from the water column were filtered out. Deciduous leaf litter was responsible for high, short-term increases to DOC concentrations whereas the amounts leached from conifer needles were relatively constant in each month. Using UV spectroscopy, changes to DOM characteristics like aromaticity, spectral slopes, and molecular weight were mainly determined by source and indicated a preferential use of the labile DOM pool by the microorganisms. Excitation-emission matrices (EEMs) collected using fluorescence spectroscopy suggested that cedar litter was an important source of protein-like fluorescence and that the nature of the fluorescing DOM components changed in the presence of microorganisms. This study demonstrates that simultaneous examination of DOC concentrations and DOM quality will allow a better understanding of the carbon dynamics that connect terrestrial with aquatic ecosystems.

Quantitative Determination of Vinpocetine in Dietary Supplements.

PubMed

French, John M T; King, Matthew D; McDougal, Owen M

2016-05-01

Current United States regulatory policies allow for the addition of pharmacologically active substances in dietary supplements if derived from a botanical source. The inclusion of certain nootropic drugs, such as vinpocetine, in dietary supplements has recently come under scrutiny due to the lack of defined dosage parameters and yet unproven short- and long-term benefits and risks to human health. This study quantified the concentration of vinpocetine in several commercially available dietary supplements and found that a highly variable range of 0.6-5.1 mg/serving was present across the tested products, with most products providing no specification of vinpocetine concentrations.

Sparse dynamics for partial differential equations

PubMed Central

Schaeffer, Hayden; Caflisch, Russel; Hauck, Cory D.; Osher, Stanley

2013-01-01

We investigate the approximate dynamics of several differential equations when the solutions are restricted to a sparse subset of a given basis. The restriction is enforced at every time step by simply applying soft thresholding to the coefficients of the basis approximation. By reducing or compressing the information needed to represent the solution at every step, only the essential dynamics are represented. In many cases, there are natural bases derived from the differential equations, which promote sparsity. We find that our method successfully reduces the dynamics of convection equations, diffusion equations, weak shocks, and vorticity equations with high-frequency source terms. PMID:23533273

Sparse dynamics for partial differential equations.

PubMed

Schaeffer, Hayden; Caflisch, Russel; Hauck, Cory D; Osher, Stanley

2013-04-23

We investigate the approximate dynamics of several differential equations when the solutions are restricted to a sparse subset of a given basis. The restriction is enforced at every time step by simply applying soft thresholding to the coefficients of the basis approximation. By reducing or compressing the information needed to represent the solution at every step, only the essential dynamics are represented. In many cases, there are natural bases derived from the differential equations, which promote sparsity. We find that our method successfully reduces the dynamics of convection equations, diffusion equations, weak shocks, and vorticity equations with high-frequency source terms.

LANDSAT 4 band 6 data evaluation

NASA Technical Reports Server (NTRS)

1983-01-01

Satellite data collected over Lake Ontario were processed to observed surface temperature values. This involved computing apparent radiance values for each point where surface temperatures were known from averaged digital count values. These radiance values were then converted by using the LOWTRAN 5A atmospheric propagation model. This model was modified by incorporating a spectral response function for the LANDSAT band 6 sensors. A downwelled radiance term derived from LOWTRAN was included to account for reflected sky radiance. A blackbody equivalent source radiance was computed. Measured temperatures were plotted against the predicted temperature. The RMS error between the data sets is 0.51K.

New horizons in microbiological food safety: Photodynamic Decontamination based on a curcumin derivative.

PubMed

Glueck, Michael; Schamberger, Barbara; Eckl, Peter; Plaetzer, Kristjan

2017-12-06

Outbreaks of foodborne diseases are regularly reported worldwide. In particular, uncooked plant food is considered risky in terms of microbiological safety. Food is also the most important transmission route for resistant microorganisms from animals to humans. Photodynamic Decontamination (PDc) of foodstuff was recently introduced as a novel approach for increasing microbiological food safety. We investigated the efficiency of PDc on plant food with different geometries (flat, spherical and complex) using a two-dimensional LED array as a light source (435 nm, 33.8 J cm -2 ) and the cationic curcumin derivative SACUR-3 as a photosensitiser. A photoantibacterial effect (>3 log 10 CFU reduction) was achieved on all flat substrates (slices of cucumber, tomato and lettuce) with 10 μM, 50 μM or 100 μM SACUR-3. The maximal photokilling with a relative inactivation of 5.6 log 10 was measured on lettuce using 50 μM of the photoactive compound. Phototreatment of non-germinated fenugreek seeds and mung beans was successful if the spherical objects were rotated while under illumination (antibacterial effect at 100 μM SACUR-3). The decontamination of mung bean germlings with a more complex geometry using the PDc approach was ineffective with the two-dimensional light source. In conclusion, PDc based on the cationic curcumin derivative SACUR-3 is very effective at improving the microbiological safety of plant food with a flat or spherical geometry. More complex objects will require the development of novel illumination devices.

Theory for noise of propellers in angular inflow with parametric studies and experimental verification

NASA Technical Reports Server (NTRS)

Hanson, Donald B.; Parzych, David J.

1993-01-01

This report presents the derivation of a frequency domain theory and working equations for radiation of propeller harmonic noise in the presence of angular inflow. In applying the acoustic analogy, integration over the tangential coordinate of the source region is performed numerically, permitting the equations to be solved without approximation for any degree of angular inflow. Inflow angle is specified in terms of yaw, pitch, and roll angles of the aircraft. Since these can be arbitrarily large, the analysis applies with equal accuracy to propellers and helicopter rotors. For thickness and loading, the derivation is given in complete detail with working equations for near and far field. However, the quadrupole derivation has been carried only far enough to show feasibility of the numerical approach. Explicit formulas are presented for computation of source elements, evaluation of Green's functions, and location of observer points in various visual and retarded coordinate systems. The resulting computer program, called WOBBLE has been written in FORTRAN and follows the notation of this report very closely. The new theory is explored to establish the effects of varying inflow angle on axial and circumferential directivity. Also, parametric studies were performed to evaluate various phenomena outside the capabilities of earlier theories, such as an unsteady thickness effect. Validity of the theory was established by comparison with test data from conventional propellers and Prop Fans in flight and in wind tunnels under a variety of operating conditions and inflow angles.

RNA Thermodynamic Structural Entropy

PubMed Central

Garcia-Martin, Juan Antonio; Clote, Peter

2015-01-01

Conformational entropy for atomic-level, three dimensional biomolecules is known experimentally to play an important role in protein-ligand discrimination, yet reliable computation of entropy remains a difficult problem. Here we describe the first two accurate and efficient algorithms to compute the conformational entropy for RNA secondary structures, with respect to the Turner energy model, where free energy parameters are determined from UV absorption experiments. An algorithm to compute the derivational entropy for RNA secondary structures had previously been introduced, using stochastic context free grammars (SCFGs). However, the numerical value of derivational entropy depends heavily on the chosen context free grammar and on the training set used to estimate rule probabilities. Using data from the Rfam database, we determine that both of our thermodynamic methods, which agree in numerical value, are substantially faster than the SCFG method. Thermodynamic structural entropy is much smaller than derivational entropy, and the correlation between length-normalized thermodynamic entropy and derivational entropy is moderately weak to poor. In applications, we plot the structural entropy as a function of temperature for known thermoswitches, such as the repression of heat shock gene expression (ROSE) element, we determine that the correlation between hammerhead ribozyme cleavage activity and total free energy is improved by including an additional free energy term arising from conformational entropy, and we plot the structural entropy of windows of the HIV-1 genome. Our software RNAentropy can compute structural entropy for any user-specified temperature, and supports both the Turner’99 and Turner’04 energy parameters. It follows that RNAentropy is state-of-the-art software to compute RNA secondary structure conformational entropy. Source code is available at https://github.com/clotelab/RNAentropy/; a full web server is available at http://bioinformatics.bc.edu/clotelab/RNAentropy, including source code and ancillary programs. PMID:26555444

RNA Thermodynamic Structural Entropy.

PubMed

Garcia-Martin, Juan Antonio; Clote, Peter

2015-01-01

Conformational entropy for atomic-level, three dimensional biomolecules is known experimentally to play an important role in protein-ligand discrimination, yet reliable computation of entropy remains a difficult problem. Here we describe the first two accurate and efficient algorithms to compute the conformational entropy for RNA secondary structures, with respect to the Turner energy model, where free energy parameters are determined from UV absorption experiments. An algorithm to compute the derivational entropy for RNA secondary structures had previously been introduced, using stochastic context free grammars (SCFGs). However, the numerical value of derivational entropy depends heavily on the chosen context free grammar and on the training set used to estimate rule probabilities. Using data from the Rfam database, we determine that both of our thermodynamic methods, which agree in numerical value, are substantially faster than the SCFG method. Thermodynamic structural entropy is much smaller than derivational entropy, and the correlation between length-normalized thermodynamic entropy and derivational entropy is moderately weak to poor. In applications, we plot the structural entropy as a function of temperature for known thermoswitches, such as the repression of heat shock gene expression (ROSE) element, we determine that the correlation between hammerhead ribozyme cleavage activity and total free energy is improved by including an additional free energy term arising from conformational entropy, and we plot the structural entropy of windows of the HIV-1 genome. Our software RNAentropy can compute structural entropy for any user-specified temperature, and supports both the Turner'99 and Turner'04 energy parameters. It follows that RNAentropy is state-of-the-art software to compute RNA secondary structure conformational entropy. Source code is available at https://github.com/clotelab/RNAentropy/; a full web server is available at http://bioinformatics.bc.edu/clotelab/RNAentropy, including source code and ancillary programs.

Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production

PubMed Central

Brick, Rachel M.; Sun, Aaron X.

2017-01-01

Abstract Adult tissue‐derived mesenchymal stem cells (MSCs) are known to produce a number of bioactive factors, including neurotrophic growth factors, capable of supporting and improving nerve regeneration. However, with a finite culture expansion capacity, MSCs are inherently limited in their lifespan and use. We examined here the potential utility of an alternative, mesenchymal‐like cell source, derived from induced pluripotent stem cells, termed induced mesenchymal progenitor cells (MiMPCs). We found that several genes were upregulated and proteins were produced in MiMPCs that matched those previously reported for MSCs. Like MSCs, the MiMPCs secreted various neurotrophic and neuroprotective factors, including brain‐derived neurotrophic factor (BDNF), interleukin‐6 (IL‐6), leukemia inhibitory factor (LIF), osteopontin, and osteonectin, and promoted neurite outgrowth in chick embryonic dorsal root ganglia (DRG) cultures compared with control cultures. Cotreatment with a pharmacological Trk‐receptor inhibitor did not result in significant decrease in MiMPC‐induced neurite outgrowth, which was however inhibited upon Jak/STAT3 blockade. These findings suggest that the MiMPC induction of DRG neurite outgrowth is unlikely to be solely dependent on BDNF, but instead Jak/STAT3 activation by IL‐6 and/or LIF is likely to be critical neurotrophic signaling pathways of the MiMPC secretome. Taken together, these findings suggest MiMPCs as a renewable, candidate source of therapeutic cells and a potential alternative to MSCs for peripheral nerve repair, in view of their ability to promote nerve growth by producing many of the same growth factors and cytokines as Schwann cells and signaling through critical neurotrophic pathways. stem cells translational Medicine 2018;7:45–58 PMID:29215199

Linear alkylbenzenes as tracers of sewage-sludge-derived inputs of organic matter, PCBs, and PAHs to sediments at the 106-mile deep water disposal site

USGS Publications Warehouse

Lamoureux, E.M.; Brownawell, Bruce J.; Bothner, Michael H.

1996-01-01

Linear alkylbenzenes (LABs) are sensitive source-specific tracers of sewage inputs to the marine environment. Because they are highly particle reactive and nonspecifically sorbed to organic matter, LABs are potential tracers of the transport of both sludge-derived organic matter and other low solubility hydrophobic contaminants (e.g., PCBs and PAHs); sediment trap studies at the 106-Mile Site have shown LABs to be valuable in testing models of sludge deposition to the sea floor. In this study we report on the distributions of LABs, PCBs, PAHs, and Ag in surface sediments collected within a month of the complete cessation of dumping (July, 1992) in the vicinity of the dump site. Total LAB concentrations were lower than those measured by Takada and coworkers in samples from nearby sites collected in 1989. LABs from both studies appear to be significantly depleted (6 to 25-fold) in surface sediments relative to excess Ag (another sludge tracer) when compared to sewage sludge and sediment trap compositions. Comparison of LAB sediment inventories to model predictions of sludge particle fluxes supports the contention that LABs have been lost from the bed. The use of LABs to examine the short-or long-term fate of sludge derived materials in deep-sea sediments should be questioned. The causes of this LAB depletion are unclear at this point, and we discuss several hypotheses. The concentrations of total PCBs and PAHs are both correlated with sludge tracers, suggesting that there may be a measurable contribution of sludge-derived inputs on top of other nonpoint sources of these contaminant classes. This possibility is consistent with the composition of these contaminants determined in recent and historical analyses of sewage sludge.

Partial independence of bioelectric and biomagnetic fields and its implications for encephalography and cardiography

NASA Astrophysics Data System (ADS)

Irimia, Andrei; Swinney, Kenneth R.; Wikswo, John P.

2009-05-01

In this paper, we clearly demonstrate that the electric potential and the magnetic field can contain different information about current sources in three-dimensional conducting media. Expressions for the magnetic fields of electric dipole and quadrupole current sources immersed in an infinite conducting medium are derived, and it is shown that two different point dipole distributions that are electrically equivalent have different magnetic fields. Although measurements of the electric potential are not sufficient to determine uniquely the characteristics of a quadrupolar source, the radial component of the magnetic field can supply the additional information needed to resolve these ambiguities and to determine uniquely the configuration of dipoles required to specify the electric quadrupoles. We demonstrate how the process can be extended to even higher-order terms in an electrically silent series of magnetic multipoles. In the context of a spherical brain source model, it has been mathematically demonstrated that the part of the neuronal current generating the electric potential lives in the orthogonal complement of the part of the current generating the magnetic potential. This implies a mathematical relationship of complementarity between electroencephalography and magnetoencephalography, although the theoretical result in question does not apply to the nonspherical case [G. Dassios, Math. Med. Biol. 25, 133 (2008)]. Our results have important practical applications in cases where electrically silent sources that generate measurable magnetic fields are of interest. Moreover, electrically silent, magnetically active moments of higher order can be useful when cancellation due to superposition of fields can occur, since this situation leads to a substantial reduction in the measurable amplitude of the signal. In this context, information derived from magnetic recordings of electrically silent, magnetically active multipoles can supplement electrical recordings for the purpose of studying the physiology of the brain. Magnetic fields of the electric multipole sources in a conducting medium surrounded by an insulating spherical shell are also presented and the relevance of this calculation to cardiographic and encephalographic experimentation is discussed.

Comparison of the landslide susceptibility models in Taipei Water Source Domain, Taiwan

NASA Astrophysics Data System (ADS)

WU, C. Y.; Yeh, Y. C.; Chou, T. H.

2017-12-01

Taipei Water Source Domain, locating at the southeast of Taipei Metropolis, is the main source of water resource in this region. Recently, the downstream turbidity often soared significantly during the typhoon period because of the upstream landslides. The landslide susceptibilities should be analysed to assess the influence zones caused by different rainfall events, and to ensure the abilities of this domain to serve enough and quality water resource. Generally, the landslide susceptibility models can be established based on either a long-term landslide inventory or a specified landslide event. Sometimes, there is no long-term landslide inventory in some areas. Thus, the event-based landslide susceptibility models are established widely. However, the inventory-based and event-based landslide susceptibility models may result in dissimilar susceptibility maps in the same area. So the purposes of this study were to compare the landslide susceptibility maps derived from the inventory-based and event-based models, and to interpret how to select a representative event to be included in the susceptibility model. The landslide inventory from Typhoon Tim in July, 1994 and Typhoon Soudelor in August, 2015 was collected, and used to establish the inventory-based landslide susceptibility model. The landslides caused by Typhoon Nari and rainfall data were used to establish the event-based model. The results indicated the high susceptibility slope-units were located at middle upstream Nan-Shih Stream basin.

Auroral Proper Motion in the Era of AMISR and EMCCD

NASA Astrophysics Data System (ADS)

Semeter, J. L.

2016-12-01

The term "aurora" is a catch-all for luminosity produced by the deposition of magnetospheric energy in the outer atmosphere. The use of this single phenomenological term occludes the rich variety of sources and mechanisms responsible for the excitation. Among these are electron thermal conduction (SAR arcs), electrostatic potential fields ("inverted-V" aurora), wave-particle resonance (Alfvenic aurora, pulsating aurora), pitch-angle scattering (diffuse aurora), and direct injection of plasma sheet particles (PBIs, substorms). Much information about auroral energization has been derived from the energy spectrum of primary particles, which may be measured directly with an in situ detector or indirectly via analysis of the atmospheric response (e.g., auroral spectroscopy, tomography, ionization). Somewhat less emphasized has been the information in the B_perp dimension. Specifically, the scale-dependent motions of auroral forms in the rest frame of the ambient plasma provide a means of partitioning both the source region and the source mechanism. These results, in turn, affect ionospheric state parameters that control the M-I coupling process-most notably, the degree of structure imparted to the conductance field. This paper describes recent results enabled by the advent of two technologies: high frame-rate, high-resolution imaging detectors, and electronically steerable incoherent scatter radar (the AMISR systems). In addition to contributing to our understanding of the aurora, these results may be used in predictive models of multi-scale energy transfer within the disturbed geospace system.

Using high-frequency sensors to identify hydroclimatological controls on storm-event variability in catchment nutrient fluxes and source zone activation

NASA Astrophysics Data System (ADS)

Blaen, Phillip; Khamis, Kieran; Lloyd, Charlotte; Krause, Stefan

2017-04-01

At the river catchment scale, storm events can drive highly variable behaviour in nutrient and water fluxes, yet short-term dynamics are frequently missed by low resolution sampling regimes. In addition, nutrient source contributions can vary significantly within and between storm events. Our inability to identify and characterise time dynamic source zone contributions severely hampers the adequate design of land use management practices in order to control nutrient exports from agricultural landscapes. Here, we utilise an 8-month high-frequency (hourly) time series of streamflow, nitrate concentration (NO3) and fluorescent dissolved organic matter concentration (FDOM) derived from optical in-situ sensors located in a headwater agricultural catchment. We characterised variability in flow and nutrient dynamics across 29 storm events. Storm events represented 31% of the time series and contributed disproportionately to nutrient loads (43% of NO3 and 36% of CDOM) relative to their duration. Principal components analysis of potential hydroclimatological controls on nutrient fluxes demonstrated that a small number of components, representing >90% of variance in the dataset, were highly significant model predictors of inter-event variability in catchment nutrient export. Hysteresis analysis of nutrient concentration-discharge relationships suggested spatially discrete source zones existed for NO3 and FDOM, and that activation of these zones varied on an event-specific basis. Our results highlight the benefits of high-frequency in-situ monitoring for characterising complex short-term nutrient dynamics and unravelling connections between hydroclimatological variability and river nutrient export and source zone activation under extreme flow conditions. These new process-based insights are fundamental to underpinning the development of targeted management measures to reduce nutrient loading of surface waters.

A finite-element analysis for steady and oscillatory supersonic flows around complex configurations

NASA Technical Reports Server (NTRS)

Morino, L.; Chen, L. T.

1974-01-01

The problem of small perturbation potential supersonic flow around complex configurations is considered. This problem requires the solution of an integral equation relating the values of the potential on the surface of the body to the values of the normal derivative, which is known from the small perturbation boundary conditions. The surface of the body is divided into small (hyperboloidal quadrilateral) surface elements, sigma sub i, which are described in terms of the Cartesian components of the four corner points. The values of the potential (and its normal derivative) within each element is assumed to be constant and equal to its value at the centroid of the element, and this yields a set of linear algebraic equations. The coefficients of the equation are given by source and doublet integrals over the surface elements, sigma sub i. The results obtained using the above formulation are compared with existing analytical and experimental results.

Annually and monthly resolved solar irradiance and atmospheric temperature data across the Hawaiian archipelago from 1998 to 2015 with interannual summary statistics.

PubMed

Bryce, Richard; Losada Carreño, Ignacio; Kumler, Andrew; Hodge, Bri-Mathias; Roberts, Billy; Brancucci Martinez-Anido, Carlo

2018-08-01

This article contains data and summary statistics of solar irradiance and dry bulb temperature across the Hawaiian archipelago resolved on a monthly basis and spanning years 1998-2015. This data was derived in association with an article titled "Consequences of Neglecting the Interannual Variability of the Solar Resource: A Case Study of Photovoltaic Power Among the Hawaiian Islands" (Bryce et al., 2018 [7]). The solar irradiance data is presented in terms of Direct Normal Irradiance (DNI), Diffuse Horizontal Irradiance (DHI), and Global Horizontal Irradiance (GHI) and was obtained from the satellite-derived data contained in the National Solar Radiation Database (NSRDB). The temperature data is also obtained from this source. We have processed the NSRDB data and compiled these monthly resolved data sets, along with interannual summary statistics including the interannual coefficient of variability.

A priori Estimates for 3D Incompressible Current-Vortex Sheets

NASA Astrophysics Data System (ADS)

Coulombel, J.-F.; Morando, A.; Secchi, P.; Trebeschi, P.

2012-04-01

We consider the free boundary problem for current-vortex sheets in ideal incompressible magneto-hydrodynamics. It is known that current-vortex sheets may be at most weakly (neutrally) stable due to the existence of surface waves solutions to the linearized equations. The existence of such waves may yield a loss of derivatives in the energy estimate of the solution with respect to the source terms. However, under a suitable stability condition satisfied at each point of the initial discontinuity and a flatness condition on the initial front, we prove an a priori estimate in Sobolev spaces for smooth solutions with no loss of derivatives. The result of this paper gives some hope for proving the local existence of smooth current-vortex sheets without resorting to a Nash-Moser iteration. Such result would be a rigorous confirmation of the stabilizing effect of the magnetic field on Kelvin-Helmholtz instabilities, which is well known in astrophysics.

A finite-element analysis for steady and oscillatory subsonic flow around complex configurations

NASA Technical Reports Server (NTRS)

Chen, L. T.; Suciu, E. O.; Morino, L.

1974-01-01

The problem of potential subsonic flow around complex configurations is considered. The solution is given of an integral equation relating the values of the potential on the surface of the body to the values of the normal derivative, which is known from the boundary conditions. The surface of the body is divided into small (hyperboloidal quadrilateral) surface elements, which are described in terms of the Cartesian components of the four corner points. The values of the potential (and its normal derivative) within each element is assumed to be constant and equal to its value at the centroid of the element. The coefficients of the equation are given by source and doublet integrals over the surface elements. Closed form evaluations of the integrals are presented. The results obtained with the above formulation are compared with existing analytical and experimental results.

Derivation of the open-circuit voltage of organic solar cells

NASA Astrophysics Data System (ADS)

Staple, Douglas B.; Oliver, Patricia A. K.; Hill, Ian G.

2014-05-01

Organic photovoltaic cells have improved in efficiency from 1% two decades ago to over 10% today. Continued improvement necessitates a theoretical understanding of the factors determining efficiency. Organic photovoltaic efficiency can be parameterized in terms of open-circuit voltage, short-circuit current, and fill factor. Here we present a theory that explains the dependencies of open-circuit voltage on semiconductor energy levels, light intensity, solar cell and light-source temperatures, charge-carrier recombination, and external fluorescence efficiency. The present theory also explains why recombination at the donor-acceptor heterointerface is a dominant process in heterojunction-based cells. Furthermore, the Carnot efficiency appears, highlighting the connection to basic thermodynamics. The theory presented here is consistent with and builds on the experimental and theoretical observations already in the literature. Crucially, the present theory can be straightforwardly derived in a line-by-line fashion using standard tools from statistical physics.

Phase-space evolution of x-ray coherence in phase-sensitive imaging.

PubMed

Wu, Xizeng; Liu, Hong

2008-08-01

X-ray coherence evolution in the imaging process plays a key role for x-ray phase-sensitive imaging. In this work we present a phase-space formulation for the phase-sensitive imaging. The theory is reformulated in terms of the cross-spectral density and associated Wigner distribution. The phase-space formulation enables an explicit and quantitative account of partial coherence effects on phase-sensitive imaging. The presented formulas for x-ray spectral density at the detector can be used for performing accurate phase retrieval and optimizing the phase-contrast visibility. The concept of phase-space shearing length derived from this phase-space formulation clarifies the spatial coherence requirement for phase-sensitive imaging with incoherent sources. The theory has been applied to x-ray Talbot interferometric imaging as well. The peak coherence condition derived reveals new insights into three-grating-based Talbot-interferometric imaging and gratings-based x-ray dark-field imaging.

Measurement of photon indistinguishability to a quantifiable uncertainty using a Hong-Ou-Mandel interferometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, Peter J.; Cheung, Jessica Y.; Chunnilall, Christopher J.

2010-04-10

We present a method for using the Hong-Ou-Mandel (HOM) interference technique to quantify photon indistinguishability within an associated uncertainty. The method allows the relative importance of various experimental factors affecting the HOM visibility to be identified, and enables the actual indistinguishability, with an associated uncertainty, to be estimated from experimentally measured quantities. A measurement equation has been derived that accounts for the non-ideal performance of the interferometer. The origin of each term of the equation is explained, along with procedures for their experimental evaluation and uncertainty estimation. These uncertainties are combined to give an overall uncertainty for the derived photonmore » indistinguishability. The analysis was applied to measurements from an interferometer sourced with photon pairs from a parametric downconversion process. The measured photon indistinguishably was found to be 0.954+/-0.036 by using the prescribed method.« less

Warming trends of perialpine lakes from homogenised time series of historical satellite and in-situ data.

PubMed

Pareeth, Sajid; Bresciani, Mariano; Buzzi, Fabio; Leoni, Barbara; Lepori, Fabio; Ludovisi, Alessandro; Morabito, Giuseppe; Adrian, Rita; Neteler, Markus; Salmaso, Nico

2017-02-01

The availability of more than thirty years of historical satellite data is a valuable source which could be used as an alternative to the sparse in-situ data. We developed a new homogenised time series of daily day time Lake Surface Water Temperature (LSWT) over the last thirty years (1986-2015) at a spatial resolution of 1km from thirteen polar orbiting satellites. The new homogenisation procedure implemented in this study corrects for the different acquisition times of the satellites standardizing the derived LSWT to 12:00 UTC. In this study, we developed new time series of LSWT for five large lakes in Italy and evaluated the product with in-situ data from the respective lakes. Furthermore, we estimated the long-term annual and summer trends, the temporal coherence of mean LSWT between the lakes, and studied the intra-annual variations and long-term trends from the newly developed LSWT time series. We found a regional warming trend at a rate of 0.017°Cyr -1 annually and 0.032°Cyr -1 during summer. Mean annual and summer LSWT temporal patterns in these lakes were found to be highly coherent. Amidst the reported rapid warming of lakes globally, it is important to understand the long-term variations of surface temperature at a regional scale. This study contributes a new method to derive long-term accurate LSWT for lakes with sparse in-situ data thereby facilitating understanding of regional level changes in lake's surface temperature. Copyright © 2016 Elsevier B.V. All rights reserved.

Residual Viremia in Treated HIV+ Individuals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conway, Jessica M.; Perelson, Alan S.

Antiretroviral therapy (ART) effectively controls HIV infection, suppressing HIV viral loads. However, some residual virus remains, below the level of detection, in HIV-infected patients on ART. Furthermore, the source of this viremia is an area of debate: does it derive primarily from activation of infected cells in the latent reservoir, or from ongoing viral replication? Our observations seem to be contradictory: there is evidence of short term evolution, implying that there must be ongoing viral replication, and viral strains should thus evolve. The phylogenetic analyses, and rare emergent drug resistance, suggest no long-term viral evolution, implying that virus derived frommore » activated latent cells must dominate. We use simple deterministic and stochastic models to gain insight into residual viremia dynamics in HIV-infected patients. Our modeling relies on two underlying assumptions for patients on suppressive ART: that latent cell activation drives viral dynamics and that the reproductive ratio of treated infection is less than 1. Nonetheless, the contribution of viral replication to residual viremia in patients on ART may be non-negligible. However, even if the portion of viremia attributable to viral replication is significant, our model predicts (1) that latent reservoir re-seeding remains negligible, and (2) some short-term viral evolution is permitted, but long-term evolution can still be limited: stochastic analysis of our model shows that de novo emergence of drug resistance is rare. Thus, our simple models reconcile the seemingly contradictory observations on residual viremia and, with relatively few parameters, recapitulates HIV viral dynamics observed in patients on suppressive therapy.« less

Residual Viremia in Treated HIV+ Individuals

DOE PAGES

Conway, Jessica M.; Perelson, Alan S.

2016-01-06

Antiretroviral therapy (ART) effectively controls HIV infection, suppressing HIV viral loads. However, some residual virus remains, below the level of detection, in HIV-infected patients on ART. Furthermore, the source of this viremia is an area of debate: does it derive primarily from activation of infected cells in the latent reservoir, or from ongoing viral replication? Our observations seem to be contradictory: there is evidence of short term evolution, implying that there must be ongoing viral replication, and viral strains should thus evolve. The phylogenetic analyses, and rare emergent drug resistance, suggest no long-term viral evolution, implying that virus derived frommore » activated latent cells must dominate. We use simple deterministic and stochastic models to gain insight into residual viremia dynamics in HIV-infected patients. Our modeling relies on two underlying assumptions for patients on suppressive ART: that latent cell activation drives viral dynamics and that the reproductive ratio of treated infection is less than 1. Nonetheless, the contribution of viral replication to residual viremia in patients on ART may be non-negligible. However, even if the portion of viremia attributable to viral replication is significant, our model predicts (1) that latent reservoir re-seeding remains negligible, and (2) some short-term viral evolution is permitted, but long-term evolution can still be limited: stochastic analysis of our model shows that de novo emergence of drug resistance is rare. Thus, our simple models reconcile the seemingly contradictory observations on residual viremia and, with relatively few parameters, recapitulates HIV viral dynamics observed in patients on suppressive therapy.« less

The Commtech Methodology: A Demand-Driven Approach to Efficient, Productive, and Measurable Technology Transfer and Commercialization

NASA Technical Reports Server (NTRS)

Horsham, Gary A. P.

1999-01-01

This paper presents a comprehensive review and assessment of a demonstration technology transfer and commercialization prouram called "CommTech". The pro-ram was conceived and initiated in early to mid-fiscal year 1995, and extended roughly three years into the future. Market research sources were used to initially gather primary technological problems and needs data from non-aerospace companies in three targeted industry sectors: environmental, surface transportation, and bioengineering. Company-supplied information served as input data to activate or start-up an internal, phased matchmaking process. This process was based on technical-level relationship exploration followed by business-level agreement negotiations. and culminated with project management and execution. Space Act Agreements represented near-term outputs. Company product or process commercialization derived from NASA Glenn support and measurable economic effects represented far-term outputs.

Non-Poissonian Distribution of Tsunami Waiting Times

NASA Astrophysics Data System (ADS)

Geist, E. L.; Parsons, T.

2007-12-01

Analysis of the global tsunami catalog indicates that tsunami waiting times deviate from an exponential distribution one would expect from a Poisson process. Empirical density distributions of tsunami waiting times were determined using both global tsunami origin times and tsunami arrival times at a particular site with a sufficient catalog: Hilo, Hawai'i. Most sources for the tsunamis in the catalog are earthquakes; other sources include landslides and volcanogenic processes. Both datasets indicate an over-abundance of short waiting times in comparison to an exponential distribution. Two types of probability models are investigated to explain this observation. Model (1) is a universal scaling law that describes long-term clustering of sources with a gamma distribution. The shape parameter (γ) for the global tsunami distribution is similar to that of the global earthquake catalog γ=0.63-0.67 [Corral, 2004]. For the Hilo catalog, γ is slightly greater (0.75-0.82) and closer to an exponential distribution. This is explained by the fact that tsunamis from smaller triggered earthquakes or landslides are less likely to be recorded at a far-field station such as Hilo in comparison to the global catalog, which includes a greater proportion of local tsunamis. Model (2) is based on two distributions derived from Omori's law for the temporal decay of triggered sources (aftershocks). The first is the ETAS distribution derived by Saichev and Sornette [2007], which is shown to fit the distribution of observed tsunami waiting times. The second is a simpler two-parameter distribution that is the exponential distribution augmented by a linear decay in aftershocks multiplied by a time constant Ta. Examination of the sources associated with short tsunami waiting times indicate that triggered events include both earthquake and landslide tsunamis that begin in the vicinity of the primary source. Triggered seismogenic tsunamis do not necessarily originate from the same fault zone, however. For example, subduction-thrust and outer-rise earthquake pairs are evident, such as the November 2006 and January 2007 Kuril Islands tsunamigenic pair. Because of variations in tsunami source parameters, such as water depth above the source, triggered tsunami events with short waiting times are not systematically smaller than the primary tsunami.

12 CFR 223.33 - What rules apply to derivative transactions?

Code of Federal Regulations, 2010 CFR

2010-01-01

... Requirements Under Section 23A § 223.33 What rules apply to derivative transactions? (a) Market terms... with affiliates comply with the market terms requirement of § 223.51. (c) Credit derivatives. A credit... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What rules apply to derivative transactions...

Host responses in tissue repair and fibrosis.

PubMed

Duffield, Jeremy S; Lupher, Mark; Thannickal, Victor J; Wynn, Thomas A

2013-01-24

Myofibroblasts accumulate in the spaces between organ structures and produce extracellular matrix (ECM) proteins, including collagen I. They are the primary "effector" cells in tissue remodeling and fibrosis. Previously, leukocyte progenitors termed fibrocytes and myofibroblasts generated from epithelial cells through epithelial-to-mesenchymal transition (EMT) were considered the primary sources of ECM-producing myofibroblasts in injured tissues. However, genetic fate mapping experiments suggest that mesenchyme-derived cells, known as resident fibroblasts, and pericytes are the primary precursors of scar-forming myofibroblasts, whereas epithelial cells, endothelial cells, and myeloid leukocytes contribute to fibrogenesis predominantly by producing key fibrogenic cytokines and by promoting cell-to-cell communication. Numerous cytokines derived from T cells, macrophages, and other myeloid cell populations are important drivers of myofibroblast differentiation. Monocyte-derived cell populations are key regulators of the fibrotic process: They act as a brake on the processes driving fibrogenesis, and they dismantle and degrade established fibrosis. We discuss the origins, modes of activation, and fate of myofibroblasts in various important fibrotic diseases and describe how manipulation of macrophage activation could help ameliorate fibrosis.

Patient-derived xenografts as preclinical neuroblastoma models.

PubMed

Braekeveldt, Noémie; Bexell, Daniel

2018-05-01

The prognosis for children with high-risk neuroblastoma is often poor and survivors can suffer from severe side effects. Predictive preclinical models and novel therapeutic strategies for high-risk disease are therefore a clinical imperative. However, conventional cancer cell line-derived xenografts can deviate substantially from patient tumors in terms of their molecular and phenotypic features. Patient-derived xenografts (PDXs) recapitulate many biologically and clinically relevant features of human cancers. Importantly, PDXs can closely parallel clinical features and outcome and serve as excellent models for biomarker and preclinical drug development. Here, we review progress in and applications of neuroblastoma PDX models. Neuroblastoma orthotopic PDXs share the molecular characteristics, neuroblastoma markers, invasive properties and tumor stroma of aggressive patient tumors and retain spontaneous metastatic capacity to distant organs including bone marrow. The recent identification of genomic changes in relapsed neuroblastomas opens up opportunities to target treatment-resistant tumors in well-characterized neuroblastoma PDXs. We highlight and discuss the features and various sources of neuroblastoma PDXs, methodological considerations when establishing neuroblastoma PDXs, in vitro 3D models, current limitations of PDX models and their application to preclinical drug testing.

Primary energy: Present status and future perspectives

NASA Astrophysics Data System (ADS)

Thielheim, K. O.

A survey of the base-load energy sources available to humans is presented, starting from the point of view that all energy used is ultimately derived from nuclear processes within the sun. Specific note is made of European energy options, noting the large dependence on imported oil. Detailed exploration of available nuclear fuel resources is carried out, with attention given to fission, fusion, and breeder reactor plants and to the state-of-the-art and technology for each. The problems of nuclear waste disposal are discussed, and long term burial in salt domes is outlined as a satisfactory method of containing the materials for acceptable periods of time. The CO2-greenhouse effect hazards caused by increased usage of coal-derived fuels are considered and precautions to be taken on a global scale to ameliorate the warming effects are recommended. The limitations to hydropower are examined, as are those of tidal power. Solar cells are projected to be produced in GW quantities by the year 2000, while wind-derived electricity is predicted to provide a minimum of 5% of the world energy needs in the future.

A 1D-2D Shallow Water Equations solver for discontinuous porosity field based on a Generalized Riemann Problem

NASA Astrophysics Data System (ADS)

Ferrari, Alessia; Vacondio, Renato; Dazzi, Susanna; Mignosa, Paolo

2017-09-01

A novel augmented Riemann Solver capable of handling porosity discontinuities in 1D and 2D Shallow Water Equation (SWE) models is presented. With the aim of accurately approximating the porosity source term, a Generalized Riemann Problem is derived by adding an additional fictitious equation to the SWEs system and imposing mass and momentum conservation across the porosity discontinuity. The modified Shallow Water Equations are theoretically investigated, and the implementation of an augmented Roe Solver in a 1D Godunov-type finite volume scheme is presented. Robust treatment of transonic flows is ensured by introducing an entropy fix based on the wave pattern of the Generalized Riemann Problem. An Exact Riemann Solver is also derived in order to validate the numerical model. As an extension of the 1D scheme, an analogous 2D numerical model is also derived and validated through test cases with radial symmetry. The capability of the 1D and 2D numerical models to capture different wave patterns is assessed against several Riemann Problems with different wave patterns.

Dioxin equivalency: Challenge to dose extrapolation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, J.F. Jr.; Silkworth, J.B.

1995-12-31

Extensive research has shown that all biological effects of dioxin-like agents are mediated via a single biochemical target, the Ah receptor (AhR), and that the relative biologic potencies of such agents in any given system, coupled with their exposure levels, may be described in terms of toxic equivalents (TEQ). It has also shown that the TEQ sources include not only chlorinated species such as the dioxins (PCDDs), PCDFs, and coplanar PCBs, but also non-chlorinated substances such as the PAHs of wood smoke, the AhR agonists of cooked meat, and the indolocarbazol (ICZ) derived from cruciferous vegetables. Humans have probably hadmore » elevated exposures to these non-chlorinated TEQ sources ever since the discoveries of fire, cooking, and the culinary use of Brassica spp. Recent assays of CYP1A2 induction show that these ``natural`` or ``traditional`` AhR agonists are contributing 50--100 times as much to average human TEQ exposures as do the chlorinated xenobiotics. Currently, the safe doses of the xenobiotic TEQ sources are estimated from their NOAELs and large extrapolation factors, derived from arbitrary mathematical models, whereas the NOAELs themselves are regarded as the safe doses for the TEQs of traditional dietary components. Available scientific data can neither support nor refute either approach to assessing the health risk of an individual chemical substance. However, if two substances be toxicologically equivalent, then their TEQ-adjusted health risks must also be equivalent, and the same dose extrapolation procedure should be used for both.« less

Water resources management: Hydrologic characterization through hydrograph simulation may bias streamflow statistics

NASA Astrophysics Data System (ADS)

Farmer, W. H.; Kiang, J. E.

2017-12-01

The development, deployment and maintenance of water resources management infrastructure and practices rely on hydrologic characterization, which requires an understanding of local hydrology. With regards to streamflow, this understanding is typically quantified with statistics derived from long-term streamgage records. However, a fundamental problem is how to characterize local hydrology without the luxury of streamgage records, a problem that complicates water resources management at ungaged locations and for long-term future projections. This problem has typically been addressed through the development of point estimators, such as regression equations, to estimate particular statistics. Physically-based precipitation-runoff models, which are capable of producing simulated hydrographs, offer an alternative to point estimators. The advantage of simulated hydrographs is that they can be used to compute any number of streamflow statistics from a single source (the simulated hydrograph) rather than relying on a diverse set of point estimators. However, the use of simulated hydrographs introduces a degree of model uncertainty that is propagated through to estimated streamflow statistics and may have drastic effects on management decisions. We compare the accuracy and precision of streamflow statistics (e.g. the mean annual streamflow, the annual maximum streamflow exceeded in 10% of years, and the minimum seven-day average streamflow exceeded in 90% of years, among others) derived from point estimators (e.g. regressions, kriging, machine learning) to that of statistics derived from simulated hydrographs across the continental United States. Initial results suggest that the error introduced through hydrograph simulation may substantially bias the resulting hydrologic characterization.

California Drought Recovery Assessment Using GRACE Satellite Gravimetry Information

NASA Astrophysics Data System (ADS)

Love, C. A.; Aghakouchak, A.; Madadgar, S.; Tourian, M. J.

2015-12-01

California has been experiencing its most extreme drought in recent history due to a combination of record high temperatures and exceptionally low precipitation. An estimate for when the drought can be expected to end is needed for risk mitigation and water management. A crucial component of drought recovery assessments is the estimation of terrestrial water storage (TWS) deficit. Previous studies on drought recovery have been limited to surface water hydrology (precipitation and/or runoff) for estimating changes in TWS, neglecting the contribution of groundwater deficits to the recovery time of the system. Groundwater requires more time to recover than surface water storage; therefore, the inclusion of groundwater storage in drought recovery assessments is essential for understanding the long-term vulnerability of a region. Here we assess the probability, for varying timescales, of California's current TWS deficit returning to its long-term historical mean. Our method consists of deriving the region's fluctuations in TWS from changes in the gravity field observed by NASA's Gravity Recovery and Climate Experiment (GRACE) satellites. We estimate the probability that meteorological inputs, precipitation minus evaporation and runoff, over different timespans will balance the current GRACE-derived TWS deficit (e.g. in 3, 6, 12 months). This method improves upon previous techniques as the GRACE-derived water deficit comprises all hydrologic sources, including surface water, groundwater, and snow cover. With this empirical probability assessment we expect to improve current estimates of California's drought recovery time, thereby improving risk mitigation.

Depletion and capture: revisiting “The source of water derived from wells"

USGS Publications Warehouse

Konikow, Leonard F.; Leake, Stanley A.

2014-01-01

A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion and capture relative to groundwater withdrawals (extraction or pumpage) have not previously been well characterized. This study assesses the partitioning of long-term cumulative withdrawal volumes into fractions derived from storage depletion and capture, where capture includes both increases in recharge and decreases in discharge. Numerical simulation of a hypothetical groundwater basin is used to further illustrate some of Theis' (1940) principles, particularly when capture is constrained by insufficient available water. Most prior studies of depletion and capture have assumed that capture is unconstrained through boundary conditions that yield linear responses. Examination of real systems indicates that capture and depletion fractions are highly variable in time and space. For a large sample of long-developed groundwater systems, the depletion fraction averages about 0.15 and the capture fraction averages about 0.85 based on cumulative volumes. Higher depletion fractions tend to occur in more arid regions, but the variation is high and the correlation coefficient between average annual precipitation and depletion fraction for individual systems is only 0.40. Because 85% of long-term pumpage is derived from capture in these real systems, capture must be recognized as a critical factor in assessing water budgets, groundwater storage depletion, and sustainability of groundwater development. Most capture translates into streamflow depletion, so it can detrimentally impact ecosystems.

Magnetic Data Interpretation for the Source-Edge Locations in Parts of the Tectonically Active Transition Zone of the Narmada-Son Lineament in Central India

NASA Astrophysics Data System (ADS)

Ghosh, G. K.

2016-02-01

The study has been carried out in the transition zone of the Narmada-Son lineament (NSL) which is seismically active with various geological complexities, upwarp movement of the mantle material into the crust through fault, fractures lamination and upwelling. NSL is one of the most prominent lineaments in central India after the Himalaya in the Indian geology. The area of investigation extends from longitude 80.25°E to 81.50°E and latitude 23.50°N to 24.37°N in the central part of the Indian continent. Different types of subsurface geological formations viz. alluvial, Gondwana, Deccan traps, Vindhyan, Mahakoshal, Granite and Gneisses groups exist in this area with varying geological ages. In this study area tectonic movement and crustal variation have been taken place during the past time and which might be reason for the variation of magnetic field. Magnetic anomaly suggests that the area has been highly disturbed which causes the Narmada-Son lineament trending in the ENE-WSW direction. Magnetic anomaly variation has been taken place due to the lithological variations subject to the changes in the geological contacts like thrusts and faults in this area. Shallow and deeper sources have been distinguished using frequency domain analysis by applying different filters. To enhance the magnetic data, various types of derivatives to identify the source-edge locations of the causative source bodies. The present study carried out the interpretation using total horizontal derivative, tilt angle derivative, horizontal tilt angle derivative and Cos (θ) derivative map to get source-edge locations. The results derived from various derivatives of magnetic data have been compared with the basement depth solutions calculated from 3D Euler deconvolution. It is suggested that total horizontal derivative, tilt angle derivative and Cos (θ) derivative are the most useful tools for identifying the multiple source edge locations of the causative bodies in this tectonically active and transition zone area. As this area is highly prone to hydrocarbon bearing zone, hence, the integrated interpretation could reliably image various thrusts and faults boundaries and the source edge locations with dip and strike orientation along with the basement lineation in encouraging exploration for better understanding of the geo-scientific data.

Sources of non-fossil-fuel emissions in carbonaceous aerosols during early winter in Chinese cities

NASA Astrophysics Data System (ADS)

Liu, Di; Li, Jun; Cheng, Zhineng; Zhong, Guangcai; Zhu, Sanyuan; Ding, Ping; Shen, Chengde; Tian, Chongguo; Chen, Yingjun; Zhi, Guorui; Zhang, Gan

2017-09-01

China experiences frequent and severe haze outbreaks from the beginning of winter. Carbonaceous aerosols are regarded as an essential factor in controlling the formation and evolution of haze episodes. To elucidate the carbon sources of air pollution, source apportionment was conducted using radiocarbon (14C) and unique molecular organic tracers. Daily 24 h PM2. 5 samples were collected continuously from October 2013 to November 2013 in 10 Chinese cities. The 14C results indicated that non-fossil-fuel (NF) emissions were predominant in total carbon (TC; average = 65 ± 7 %). Approximately half of the EC was derived primarily from biomass burning (BB) (average = 46 ± 11 %), while over half of the organic carbon (OC) fraction comprised NF (average = 68 ± 7 %). On average, the largest contributor to TC was NF-derived secondary OC (SOCnf), which accounted for 46 ± 7 % of TC, followed by SOC derived from fossil fuels (FF) (SOCf; 16 ± 3 %), BB-derived primary OC (POCbb; 13 ± 5 %), POC derived from FF (POCf; 12 ± 3 %), EC derived from FF (ECf; 7 ± 2 %) and EC derived from BB (ECbb; 6 ± 2 %). The regional background carbonaceous aerosol composition was characterized by NF sources; POCs played a major role in northern China, while SOCs contributed more in other regions. However, during haze episodes, there were no dramatic changes in the carbon source or composition in the cities under study, but the contribution of POC from both FF and NF increased significantly.

INEEL Subregional Conceptual Model Report Volume 3: Summary of Existing Knowledge of Natural and Anthropogenic Influences on the Release of Contaminants to the Subsurface Environment from Waste Source Terms at the INEEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paul L. Wichlacz

2003-09-01

This source-term summary document is intended to describe the current understanding of contaminant source terms and the conceptual model for potential source-term release to the environment at the Idaho National Engineering and Environmental Laboratory (INEEL), as presented in published INEEL reports. The document presents a generalized conceptual model of the sources of contamination and describes the general categories of source terms, primary waste forms, and factors that affect the release of contaminants from the waste form into the vadose zone and Snake River Plain Aquifer. Where the information has previously been published and is readily available, summaries of the inventorymore » of contaminants are also included. Uncertainties that affect the estimation of the source term release are also discussed where they have been identified by the Source Term Technical Advisory Group. Areas in which additional information are needed (i.e., research needs) are also identified.« less

Suspended-sediment sources in an urban watershed, Northeast Branch Anacostia River, Maryland

USGS Publications Warehouse

Devereux, Olivia H.; Prestegaard, Karen L.; Needelman, Brian A.; Gellis, Allen C.

2010-01-01

Fine sediment sources were characterized by chemical composition in an urban watershed, the Northeast Branch Anacostia River, which drains to the Chesapeake Bay. Concentrations of 63 elements and two radionuclides were measured in possible land-based sediment sources and suspended sediment collected from the water column at the watershed outlet during storm events. These tracer concentrations were used to determine the relative quantity of suspended sediment contributed by each source. Although this is an urbanized watershed, there was not a distinct urban signature that can be evaluated except for the contributions from road surfaces. We identified the sources of fine sediment by both physiographic province (Piedmont and Coastal Plain) and source locale (streambanks, upland and street residue) by using different sets of elemental tracers. The Piedmont contributed the majority of the fine sediment for seven of the eight measured storms. The streambanks contributed the greatest quantity of fine sediment when evaluated by source locale. Street residue contributed 13% of the total suspended sediment on average and was the source most concentrated in anthropogenically enriched elements. Combining results from the source locale and physiographic province analyses, most fine sediment in the Northeast Branch watershed is derived from streambanks that contain sediment eroded from the Piedmont physiographic province of the watershed. Sediment fingerprinting analyses are most useful when longer term evaluations of sediment erosion and storage are also available from streambank-erosion measurements, sediment budget and other methods.

Gene and protein nomenclature in public databases

PubMed Central

Fundel, Katrin; Zimmer, Ralf

2006-01-01

Background Frequently, several alternative names are in use for biological objects such as genes and proteins. Applications like manual literature search, automated text-mining, named entity identification, gene/protein annotation, and linking of knowledge from different information sources require the knowledge of all used names referring to a given gene or protein. Various organism-specific or general public databases aim at organizing knowledge about genes and proteins. These databases can be used for deriving gene and protein name dictionaries. So far, little is known about the differences between databases in terms of size, ambiguities and overlap. Results We compiled five gene and protein name dictionaries for each of the five model organisms (yeast, fly, mouse, rat, and human) from different organism-specific and general public databases. We analyzed the degree of ambiguity of gene and protein names within and between dictionaries, to a lexicon of common English words and domain-related non-gene terms, and we compared different data sources in terms of size of extracted dictionaries and overlap of synonyms between those. The study shows that the number of genes/proteins and synonyms covered in individual databases varies significantly for a given organism, and that the degree of ambiguity of synonyms varies significantly between different organisms. Furthermore, it shows that, despite considerable efforts of co-curation, the overlap of synonyms in different data sources is rather moderate and that the degree of ambiguity of gene names with common English words and domain-related non-gene terms varies depending on the considered organism. Conclusion In conclusion, these results indicate that the combination of data contained in different databases allows the generation of gene and protein name dictionaries that contain significantly more used names than dictionaries obtained from individual data sources. Furthermore, curation of combined dictionaries considerably increases size and decreases ambiguity. The entries of the curated synonym dictionary are available for manual querying, editing, and PubMed- or Google-search via the ProThesaurus-wiki. For automated querying via custom software, we offer a web service and an exemplary client application. PMID:16899134

Developing a comprehensive time series of GDP per capita for 210 countries from 1950 to 2015

PubMed Central

2012-01-01

Background Income has been extensively studied and utilized as a determinant of health. There are several sources of income expressed as gross domestic product (GDP) per capita, but there are no time series that are complete for the years between 1950 and 2015 for the 210 countries for which data exist. It is in the interest of population health research to establish a global time series that is complete from 1950 to 2015. Methods We collected GDP per capita estimates expressed in either constant US dollar terms or international dollar terms (corrected for purchasing power parity) from seven sources. We applied several stages of models, including ordinary least-squares regressions and mixed effects models, to complete each of the seven source series from 1950 to 2015. The three US dollar and four international dollar series were each averaged to produce two new GDP per capita series. Results and discussion Nine complete series from 1950 to 2015 for 210 countries are available for use. These series can serve various analytical purposes and can illustrate myriad economic trends and features. The derivation of the two new series allows for researchers to avoid any series-specific biases that may exist. The modeling approach used is flexible and will allow for yearly updating as new estimates are produced by the source series. Conclusion GDP per capita is a necessary tool in population health research, and our development and implementation of a new method has allowed for the most comprehensive known time series to date. PMID:22846561

Accreting, highly magnetized neutron stars at the Eddington limit: a study of the 2016 outburst of SMC X-3

NASA Astrophysics Data System (ADS)

Koliopanos, Filippos; Vasilopoulos, Georgios

2018-06-01

Aims: We study the temporal and spectral characteristics of SMC X-3 during its recent (2016) outburst to probe accretion onto highly magnetized neutron stars (NSs) at the Eddington limit. Methods: We obtained XMM-Newton observations of SMC X-3 and combined them with long-term observations by Swift. We performed a detailed analysis of the temporal and spectral behavior of the source, as well as its short- and long-term evolution. We have also constructed a simple toy-model (based on robust theoretical predictions) in order to gain insight into the complex emission pattern of SMC X-3. Results: We confirm the pulse period of the system that has been derived by previous works and note that the pulse has a complex three-peak shape. We find that the pulsed emission is dominated by hard photons, while at energies below 1 keV, the emission does not pulsate. We furthermore find that the shape of the pulse profile and the short- and long-term evolution of the source light-curve can be explained by invoking a combination of a "fan" and a "polar" beam. The results of our temporal study are supported by our spectroscopic analysis, which reveals a two-component emission, comprised of a hard power law and a soft thermal component. We find that the latter produces the bulk of the non-pulsating emission and is most likely the result of reprocessing the primary hard emission by optically thick material that partly obscures the central source. We also detect strong emission lines from highly ionized metals. The strength of the emission lines strongly depends on the phase. Conclusions: Our findings are in agreement with previous works. The energy and temporal evolution as well as the shape of the pulse profile and the long-term spectra evolution of the source are consistent with the expected emission pattern of the accretion column in the super-critical regime, while the large reprocessing region is consistent with the analysis of previously studied X-ray pulsars observed at high accretion rates. This reprocessing region is consistent with recently proposed theoretical and observational works that suggested that highly magnetized NSs occupy a considerable fraction of ultraluminous X-ray sources.

Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies.

PubMed

Dinh, Phuong-Uyen C; Cores, Jhon; Hensley, M Taylor; Vandergriff, Adam C; Tang, Junnan; Allen, Tyler A; Caranasos, Thomas G; Adler, Kenneth B; Lobo, Leonard J; Cheng, Ke

2017-06-30

Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provide an ideal source for stem-cell based therapy, mesenchymal stem cells (MSCs) remain the most popular cell therapy product for the treatment of lung diseases. Surgical lung biopsies can be the tissue source but such procedures carry a high risk of mortality. In this study we demonstrate that therapeutic lung cells, termed "lung spheroid cells" (LSCs) can be generated from minimally invasive transbronchial lung biopsies using a three-dimensional culture technique. The cells were then characterized by flow cytometry and immunohistochemistry. Angiogenic potential was tested by in-vitro HUVEC tube formation assay. In-vivo bio- distribution of LSCs was examined in athymic nude mice after intravenous delivery. From one lung biopsy, we are able to derive >50 million LSC cells at Passage 2. These cells were characterized by flow cytometry and immunohistochemistry and were shown to represent a mixture of lung stem cells and supporting cells. When introduced systemically into nude mice, LSCs were retained primarily in the lungs for up to 21 days. Here, for the first time, we demonstrated that direct culture and expansion of human lung progenitor cells from pulmonary tissues, acquired through a minimally invasive biopsy, is possible and straightforward with a three-dimensional culture technique. These cells could be utilized in long-term expansion of lung progenitor cells and as part of the development of cell-based therapies for the treatment of lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).

Applications of Cosmological Perturbation Theory

NASA Astrophysics Data System (ADS)

Christopherson, Adam J.

2011-06-01

Cosmological perturbation theory is crucial for our understanding of the universe. The linear theory has been well understood for some time, however developing and applying the theory beyond linear order is currently at the forefront of research in theoretical cosmology. This thesis studies the applications of perturbation theory to cosmology and, specifically, to the early universe. Starting with some background material introducing the well-tested 'standard model' of cosmology, we move on to develop the formalism for perturbation theory up to second order giving evolution equations for all types of scalar, vector and tensor perturbations, both in gauge dependent and gauge invariant form. We then move on to the main result of the thesis, showing that, at second order in perturbation theory, vorticity is sourced by a coupling term quadratic in energy density and entropy perturbations. This source term implies a qualitative difference to linear order. Thus, while at linear order vorticity decays with the expansion of the universe, the same is not true at higher orders. This will have important implications on future measurements of the polarisation of the Cosmic Microwave Background, and could give rise to the generation of a primordial seed magnetic field. Having derived this qualitative result, we then estimate the scale dependence and magnitude of the vorticity power spectrum, finding, for simple power law inputs a small, blue spectrum. The final part of this thesis concerns higher order perturbation theory, deriving, for the first time, the metric tensor, gauge transformation rules and governing equations for fully general third order perturbations. We close with a discussion of natural extensions to this work and other possible ideas for off-shooting projects in this continually growing field.

Post-disaster supply chain interdependent critical infrastructure system restoration: A review of data necessary and available for modeling

USGS Publications Warehouse

Ramachandran, Varun; Long, Suzanna K.; Shoberg, Thomas G.; Corns, Steven; Carlo, Hector J.

2016-01-01

The majority of restoration strategies in the wake of large-scale disasters have focused on short-term emergency response solutions. Few consider medium- to long-term restoration strategies to reconnect urban areas to national supply chain interdependent critical infrastructure systems (SCICI). These SCICI promote the effective flow of goods, services, and information vital to the economic vitality of an urban environment. To re-establish the connectivity that has been broken during a disaster between the different SCICI, relationships between these systems must be identified, formulated, and added to a common framework to form a system-level restoration plan. To accomplish this goal, a considerable collection of SCICI data is necessary. The aim of this paper is to review what data are required for model construction, the accessibility of these data, and their integration with each other. While a review of publically available data reveals a dearth of real-time data to assist modeling long-term recovery following an extreme event, a significant amount of static data does exist and these data can be used to model the complex interdependencies needed. For the sake of illustration, a particular SCICI (transportation) is used to highlight the challenges of determining the interdependencies and creating models capable of describing the complexity of an urban environment with the data publically available. Integration of such data as is derived from public domain sources is readily achieved in a geospatial environment, after all geospatial infrastructure data are the most abundant data source and while significant quantities of data can be acquired through public sources, a significant effort is still required to gather, develop, and integrate these data from multiple sources to build a complete model. Therefore, while continued availability of high quality, public information is essential for modeling efforts in academic as well as government communities, a more streamlined approach to a real-time acquisition and integration of these data is essential.

Mathematical models of Neospora caninum infection in dairy cattle: transmission and options for control.

PubMed

French, N P; Clancy, D; Davison, H C; Trees, A J

1999-10-01

The transmission and control of Neospora caninum infection in dairy cattle was examined using deterministic and stochastic models. Parameter estimates were derived from recent studies conducted in the UK and from the published literature. Three routes of transmission were considered: maternal vertical transmission with a high probability (0.95), horizontal transmission from infected cattle within the herd, and horizontal transmission from an independent external source. Putative infection via pooled colostrum was used as an example of within-herd horizontal transmission, and the recent finding that the dog is a definitive host of N. caninum supported the inclusion of an external independent source of infection. The predicted amount of horizontal transmission required to maintain infection at levels commonly observed in field studies in the UK and elsewhere, was consistent with that observed in studies of post-natal seroconversion (0.85-9.0 per 100 cow-years). A stochastic version of the model was used to simulate the spread of infection in herds of 100 cattle, with a mean infection prevalence similar to that observed in UK studies (around 20%). The distributions of infected and uninfected cattle corresponded closely to Normal distributions, with S.D.s of 6.3 and 7.0, respectively. Control measures were considered by altering birth, death and horizontal transmission parameters. A policy of annual culling of infected cattle very rapidly reduced the prevalence of infection, and was shown to be the most effective method of control in the short term. Not breeding replacements from infected cattle was also effective in the short term, particularly in herds with a higher turnover of cattle. However, the long-term effectiveness of these measures depended on the amount and source of horizontal infection. If the level of within-herd transmission was above a critical threshold, then a combination of reducing within-herd, and blocking external sources of transmission was required to permanently eliminate infection.

Spatial and temporal dynamics of nitrate fluxes in a mesoscale catchment

NASA Astrophysics Data System (ADS)

Muller, C.; Musolff, A.; Strachauer, U.; Brauns, M.; Tarasova, L.; Merz, R.; Knoeller, K.

2017-12-01

Spatially and temporally variable and often superimposing processes like mobilization and turnover of N-species strongly affect nitrate fluxes at catchment outlets. It remains thus challenging to determine dominant nitrate sources to derive an effective river management. Here, we combine data sets from two spatially highly resolved key-date monitoring campaigns of nitrate fluxes along a mesoscale catchment in Germany with four years of monitoring data from two representative sites within the catchment. The study area is characterized by a strong land use gradient from pristine headwaters to lowland sub-catchments with intense agricultural land use and wastewater sources. Flow conditions were assessed by a hydrograph separation showing the clear dominance of base flow during both investigations. However, the absolute amounts of discharge differed significantly from each other (outlet: 1.42 m³ s-1 versus 0.43 m³ s-1). Nitrate concentration and flux in the headwater was found to be low. In contrast, nitrate loads further downstream originate from anthropogenic sources such as effluents from wastewater treatment plants (WWTP) and agricultural land use. The agricultural contribution did not vary in terms of nitrate concentration and isotopic signature between the years but in terms of flux. The contrasting amounts of discharge between the years led to a strongly increased relative wastewater contribution with decreasing discharge. This was mainly manifested in elevated δ18O-NO3- values downstream from the wastewater discharge. The four-year monitoring at two sides clearly indicates the chemostatic character of the agricultural N-source and its distinct, yet stable isotopic fingerprint. Denitrification was found to play no dominant role only for controlling nitrate loads in the river. The spatially highly resolved monitoring approach helped to accurately define hot spots of nitrate inputs into the stream while the long-term information allowed a classification of the results with respect to the seasonal N-dynamics in the catchment.

Chemical Contaminants as Stratigraphic Markers for the Anthropocene

NASA Astrophysics Data System (ADS)

Kruge, M. A.

2012-12-01

Thousands and even millions of years from now, widespread anthropogenic contaminants in sediments would likely persist, incorporated into the geological record. They would inadvertently preserve evidence of our present era (informally designated as the Anthropocene Epoch) characterized by large human populations engaged in intensive industrial and agricultural activities. Hypothetical geologists in the distant future would likely find unusually high concentrations of a wide variety of contaminants at stratigraphic levels corresponding to our present time, analogous to the iridium anomaly marking the bolide impact event at the close of the Cretaceous Period. These would include both organic and inorganic substances, such as industrially-derived heavy metals (e.g., Hg, Pb, Cr, Zn) and hydrocarbons, both petrogenic (derived directly from petroleum) and pyrogenic (combustion products). While there are natural sources for these materials, such as volcanic eruptions, wildfires, and oil seeps, their co-occurrence would provide a signature characteristic of human activity. Diagnostic assemblages of organic compounds would carry an anthropogenic imprint. The distribution of polycyclic aromatic hydrocarbons (PAHs) in a sediment sample could distinguish between natural and human sources. Stable isotopic signatures would provide additional evidence. Concentrations of contaminants in the sedimentary record would increase exponentially with increasing proximity to urban source areas, where at present billions of people are collectively consuming vast quantities of fossil fuels and generating large amounts of waste. Aolian and marine transport prior to deposition has been seen at present to globally redistribute detectable amounts of contaminants including Hg and PAHs, even at great distances from principal source areas. For organic contaminants, deposition in an anoxic sedimentary environment could insure their preservation, increasing the likelihood of their inclusion in the long-term stratigraphic record, establishing markers of the Anthropocene Epoch for millions of years to come.

Analysis of Discontinuities in a Rectangular Waveguide Using Dyadic Green's Function Approach in Conjunction with Method of Moments

NASA Technical Reports Server (NTRS)

Deshpande, M. D.

1997-01-01

The dyadic Green's function for an electric current source placed in a rectangular waveguide is derived using a magnetic vector potential approach. A complete solution for the electric and magnetic fields including the source location is obtained by simple differentiation of the vector potential around the source location. The simple differentiation approach which gives electric and magnetic fields identical to an earlier derivation is overlooked by the earlier workers in the derivation of the dyadic Green's function particularly around the source location. Numerical results obtained using the Green's function approach are compared with the results obtained using the Finite Element Method (FEM).

Derivation of kinetic equations from non-Wiener stochastic differential equations

NASA Astrophysics Data System (ADS)

Basharov, A. M.

2013-12-01

Kinetic differential-difference equations containing terms with fractional derivatives and describing α -stable Levy processes with 0 < α < 1 have been derived in a unified manner in terms of one-dimensional stochastic differential equations controlled merely by the Poisson processes.

Cosine beamforming

NASA Astrophysics Data System (ADS)

Ruigrok, Elmer; Wapenaar, Kees

2014-05-01

In various application areas, e.g., seismology, astronomy and geodesy, arrays of sensors are used to characterize incoming wavefields due to distant sources. Beamforming is a general term for phased-adjusted summations over the different array elements, for untangling the directionality and elevation angle of the incoming waves. For characterizing noise sources, beamforming is conventionally applied with a temporal Fourier and a 2D spatial Fourier transform, possibly with additional weights. These transforms become aliased for higher frequencies and sparser array-element distributions. As a partial remedy, we derive a kernel for beamforming crosscorrelated data and call it cosine beamforming (CBF). By applying beamforming not directly to the data, but to crosscorrelated data, the sampling is effectively increased. We show that CBF, due to this better sampling, suffers less from aliasing and yields higher resolution than conventional beamforming. As a flip-side of the coin, the CBF output shows more smearing for spherical waves than conventional beamforming.

Theobroma cacao: Review of the Extraction, Isolation, and Bioassay of Its Potential Anti-cancer Compounds

PubMed Central

Baharum, Zainal; Akim, Abdah Md; Hin, Taufiq Yap Yun; Hamid, Roslida Abdul; Kasran, Rosmin

2016-01-01

Plants have been a good source of therapeutic agents for thousands of years; an impressive number of modern drugs used for treating human diseases are derived from natural sources. The Theobroma cacao tree, or cocoa, has recently garnered increasing attention and become the subject of research due to its antioxidant properties, which are related to potential anti-cancer effects. In the past few years, identifying and developing active compounds or extracts from the cocoa bean that might exert anti-cancer effects have become an important area of health- and biomedicine-related research. This review provides an updated overview of T. cacao in terms of its potential anti-cancer compounds and their extraction, in vitro bioassay, purification, and identification. This article also discusses the advantages and disadvantages of the techniques described and reviews the processes for future perspectives of analytical methods from the viewpoint of anti-cancer compound discovery. PMID:27019680

Rational Autologous Cell Sources For Therapy of Heart Failure - Vehicles and Targets For Gene and RNA Therapies.

PubMed

Lampinen, Milla; Vento, Antti; Laurikka, Jari; Nystedt, Johanna; Mervaala, Eero; Harjula, Ari; Kankuri, Esko

2016-01-01

This review focuses on the possibilities for intraoperative processing and isolation of autologous cells, particularly atrial appendage-derived cells (AADCs) and cellular micrografts, and their straightforward use in cell transplantation for heart failure therapy. We review the potential of autologous tissues to serve as sources for cell therapy and consider especially those tissues that are used in surgery but from which the excess is currently discarded as surgical waste. We compare the inculture expanded cells to the freshly isolated ones in terms of evidence-based cost-efficacy and their usability as gene- and RNA therapy vehicles. We also review how financial and authority-based decisions and restrictions sculpt the landscape for patients to participate in academic-based trials. Finally, we provide an insight example into AADCs isolation and processing for epicardial therapy during coronary artery bypass surgery.

A simplified Mach number scaling law for helicopter rotor noise

NASA Technical Reports Server (NTRS)

Aravamudan, K. S.; Lee, A.; Harris, W. L.

1978-01-01

Mach number scaling laws are derived for the rotational and the high-frequency broadband noise from helicopter rotors. The rotational scaling law is obtained directly from the theory of Lowson and Ollerhead (1969) by exploiting the properties of the dominant terms in the expression for the complex Fourier coefficients of sound radiation from a point source. The scaling law for the high-frequency broadband noise is obtained by assuming that the noise sources are acoustically compact and computing the instantaneous pressure due to an element on an airfoil where vortices are shed. Experimental results on the correlation lengths for stationary airfoils are extended to rotating airfoils. On the assumption that the correlation length varies as the boundary layer displacement thickness, it is found that the Mach number scaling law contains a factor of Mach number raised to the exponent 5.8. Both scaling laws were verified by model tests.

Dynamics of charged bulk viscous collapsing cylindrical source with heat flux

NASA Astrophysics Data System (ADS)

Shah, S. M.; Abbas, G.

2017-04-01

In this paper, we have explored the effects of dissipation on the dynamics of charged bulk viscous collapsing cylindrical source which allows the out-flow of heat flux in the form of radiations. The Misner-Sharp formalism has been implemented to drive the dynamical equation in terms of proper time and radial derivatives. We have investigated the effects of charge and bulk viscosity on the dynamics of collapsing cylinder. To determine the effects of radial heat flux, we have formulated the heat transport equations in the context of Müller-Israel-Stewart theory by assuming that thermodynamics viscous/heat coupling coefficients can be neglected within some approximations. In our discussion, we have introduced the viscosity by the standard (non-causal) thermodynamics approach. The dynamical equations have been coupled with the heat transport equation; the consequences of the resulting coupled heat equation have been analyzed in detail.

Stochastic interpretation of the advection-diffusion equation and its relevance to bed load transport

NASA Astrophysics Data System (ADS)

Ancey, C.; Bohorquez, P.; Heyman, J.

2015-12-01

The advection-diffusion equation is one of the most widespread equations in physics. It arises quite often in the context of sediment transport, e.g., for describing time and space variations in the particle activity (the solid volume of particles in motion per unit streambed area). Phenomenological laws are usually sufficient to derive this equation and interpret its terms. Stochastic models can also be used to derive it, with the significant advantage that they provide information on the statistical properties of particle activity. These models are quite useful when sediment transport exhibits large fluctuations (typically at low transport rates), making the measurement of mean values difficult. Among these stochastic models, the most common approach consists of random walk models. For instance, they have been used to model the random displacement of tracers in rivers. Here we explore an alternative approach, which involves monitoring the evolution of the number of particles moving within an array of cells of finite length. Birth-death Markov processes are well suited to this objective. While the topic has been explored in detail for diffusion-reaction systems, the treatment of advection has received no attention. We therefore look into the possibility of deriving the advection-diffusion equation (with a source term) within the framework of birth-death Markov processes. We show that in the continuum limit (when the cell size becomes vanishingly small), we can derive an advection-diffusion equation for particle activity. Yet while this derivation is formally valid in the continuum limit, it runs into difficulty in practical applications involving cells or meshes of finite length. Indeed, within our stochastic framework, particle advection produces nonlocal effects, which are more or less significant depending on the cell size and particle velocity. Albeit nonlocal, these effects look like (local) diffusion and add to the intrinsic particle diffusion (dispersal due to velocity fluctuations), with the important consequence that local measurements depend on both the intrinsic properties of particle displacement and the dimensions of the measurement system.

Chondrocyte and Mesenchymal Stem Cell Derived Engineered Cartilage Exhibits Differential Sensitivity to Pro-Inflammatory Cytokines.

PubMed

Mohanraj, Bhavana; Huang, Alice H; Yeger-McKeever, Meira J; Schmidt, Megan J; Dodge, George R; Mauck, Robert L

2018-05-29

Tissue engineering is a promising approach for the repair of articular cartilage defects, with engineered constructs emerging that match native tissue properties. However, the inflammatory environment of the damaged joint might compromise outcomes, and this may be impacted by the choice of cell source in terms of their ability to operate anabolically in an inflamed environment. Here, we compared the response of engineered cartilage derived from native chondrocytes and mesenchymal stem cells (MSCs) to challenge by TNFα and IL-1β in order to determine if either cell type possessed an inherent advantage. Compositional (extracellular matrix) and functional (mechanical) characteristics, as well as the release of catabolic mediators (matrix metalloproteinases (MMPs), nitric oxide (NO)) were assessed to determine cell- and tissue- level changes following exposure to IL-1β or TNF-α. Results demonstrated that MSC-derived constructs were more sensitive to inflammatory mediators than chondrocyte-derived constructs, exhibiting a greater loss of proteoglycans and functional properties at lower cytokine concentrations. While MSCs and chondrocytes both have the capacity to form functional engineered cartilage in vitro, this study suggests that the presence of an inflammatory environment is more likely to impair the in vivo success of MSC-derived cartilage repair. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Medically-Derived (131)I as a Tool for Investigating the Fate of Wastewater Nitrogen in Aquatic Environments.

PubMed

Rose, Paula S; Smith, Joseph P; Aller, Robert C; Cochran, J Kirk; Swanson, R Lawrence; Coffin, Richard B

2015-09-01

Medically derived (131)I (t1/2 = 8.04 d) is discharged from water pollution control plants (WPCPs) in sewage effluent. Iodine's nutrient-like behavior and the source-specificity of (131)I make this radionuclide a potentially valuable tracer in wastewater nitrogen studies. Iodine-131 was measured in Potomac River water and sediments in the vicinity of the Blue Plains WPCP, Washington, DC, USA. Dissolved (131)I showed a strong, positive correlation with δ(15)N values of nitrate (δ(15)NO3(-)) in the river, the latter being a traditional indicator of nutrient inputs and recycling. Surface water δ(15)NO3(-) values ranged from 8.7 to 33.4‰; NO3(-) + NO2(-) concentrations were 0.39-2.79 mg N L(-1) (26-186 μM). Sediment profiles of particulate (131)I and δ(15)N indicate rapid mixing or sedimentation and in many cases remineralization of a heavy nitrogen source consistent with wastewater nitrogen. Values of δ(15)N in sediments ranged from 4.7 to 9.3‰. This work introduces (131)I as a tool to investigate the short-term fate of wastewater nitrogen in the Potomac River and demonstrates the general utility of (131)I in aquatic research.

Looking at Earth observation impacts with fresh eyes: a Landsat example

NASA Astrophysics Data System (ADS)

Wu, Zhuoting; Snyder, Greg; Quirk, Bruce; Stensaas, Greg; Vadnais, Carolyn; Babcock, Michael; Dale, Erin; Doucette, Peter

2016-05-01

The U. S. Geological Survey (USGS) initiated the Requirements, Capabilities and Analysis for Earth Observations (RCA-EO) activity in the Land Remote Sensing (LRS) program to provide a structured approach to collect, store, maintain, and analyze user requirements and Earth observing system capabilities information. RCA-EO enables the collection of information on current key Earth observation products, services, and projects, and to evaluate them at different organizational levels within an agency, in terms of how reliant they are on Earth observation data from all sources, including spaceborne, airborne, and ground-based platforms. Within the USGS, RCA-EO has engaged over 500 subject matter experts in this assessment, and evaluated the impacts of more than 1000 different Earth observing data sources on 345 key USGS products and services. This paper summarizes Landsat impacts at various levels of the organizational structure of the USGS and highlights the feedback of the subject matter experts regarding Landsat data and Landsat-derived products. This feedback is expected to inform future Landsat mission decision making. The RCA-EO approach can be applied in a much broader scope to derive comprehensive knowledge of Earth observing system usage and impacts, to inform product and service development and remote sensing technology innovation beyond the USGS.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maasakkers, Joannes D.; Jacob, Daniel J.; Sulprizio, Melissa P.

Here we present a gridded inventory of US anthropogenic methane emissions with 0.1° × 0.1° spatial resolution, monthly temporal resolution, and detailed scaledependent error characterization. The inventory is designed to be consistent with the 2016 US Environmental Protection Agency (EPA) Inventory of US Greenhouse Gas Emissions and Sinks (GHGI) for 2012. The EPA inventory is available only as national totals for different source types. We use a wide range of databases at the state, county, local, and point source level to disaggregate the inventory and allocate the spatial and temporal distribution of emissions for individual source types. Results show largemore » differences with the EDGAR v4.2 global gridded inventory commonly used as a priori estimate in inversions of atmospheric methane observations. We derive grid-dependent error statistics for individual source types from comparison with the Environmental Defense Fund (EDF) regional inventory for Northeast Texas. These error statistics are independently verified by comparison with the California Greenhouse Gas Emissions Measurement (CALGEM) grid-resolved emission inventory. Finally, our gridded, time-resolved inventory provides an improved basis for inversion of atmospheric methane observations to estimate US methane emissions and interpret the results in terms of the underlying processes.« less

Gridded National Inventory of U.S. Methane Emissions

NASA Technical Reports Server (NTRS)

Maasakkers, Joannes D.; Jacob, Daniel J.; Sulprizio, Melissa P.; Turner, Alexander J.; Weitz, Melissa; Wirth, Tom; Hight, Cate; DeFigueiredo, Mark; Desai, Mausami; Schmeltz, Rachel;

Information theoretic approach for assessing image fidelity in photon-counting arrays.

PubMed

Narravula, Srikanth R; Hayat, Majeed M; Javidi, Bahram

2010-02-01

The method of photon-counting integral imaging has been introduced recently for three-dimensional object sensing, visualization, recognition and classification of scenes under photon-starved conditions. This paper presents an information-theoretic model for the photon-counting imaging (PCI) method, thereby providing a rigorous foundation for the merits of PCI in terms of image fidelity. This, in turn, can facilitate our understanding of the demonstrated success of photon-counting integral imaging in compressive imaging and classification. The mutual information between the source and photon-counted images is derived in a Markov random field setting and normalized by the source-image's entropy, yielding a fidelity metric that is between zero and unity, which respectively corresponds to complete loss of information and full preservation of information. Calculations suggest that the PCI fidelity metric increases with spatial correlation in source image, from which we infer that the PCI method is particularly effective for source images with high spatial correlation; the metric also increases with the reduction in photon-number uncertainty. As an application to the theory, an image-classification problem is considered showing a congruous relationship between the fidelity metric and classifier's performance.

Hepatocyte transplantation and advancements in alternative cell sources for liver-based regenerative medicine.

PubMed

Lee, Charlotte A; Sinha, Siddharth; Fitzpatrick, Emer; Dhawan, Anil

2018-06-01

Human hepatocyte transplantation has been actively perused as an alternative to liver replacement for acute liver failure and liver-based metabolic defects. Current challenges in this field include a limited cell source, reduced cell viability following cryopreservation and poor engraftment of cells into the recipient liver with consequent limited life span. As a result, alternative stem cell sources such as pluripotent stem cells, fibroblasts, hepatic progenitor cells, amniotic epithelial cells and mesenchymal stem/stromal cells (MSCs) can be used to generate induced hepatocyte like cells (HLC) with each technique exhibiting advantages and disadvantages. HLCs may have comparable function to primary human hepatocytes and could offer patient-specific treatment. However, long-term functionality of transplanted HLCs and the potential oncogenic risks of using stem cells have yet to be established. The immunomodulatory effects of MSCs are promising, and multiple clinical trials are investigating their effect in cirrhosis and acute liver failure. Here, we review the current status of hepatocyte transplantation, alternative cell sources to primary human hepatocytes and their potential in liver regeneration. We also describe recent clinical trials using hepatocytes derived from stem cells and their role in improving the phenotype of several liver diseases.

Gridded national inventory of U.S. methane emissions

DOE PAGES

Maasakkers, Joannes D.; Jacob, Daniel J.; Sulprizio, Melissa P.; ...

2016-11-16

Here we present a gridded inventory of US anthropogenic methane emissions with 0.1° × 0.1° spatial resolution, monthly temporal resolution, and detailed scaledependent error characterization. The inventory is designed to be consistent with the 2016 US Environmental Protection Agency (EPA) Inventory of US Greenhouse Gas Emissions and Sinks (GHGI) for 2012. The EPA inventory is available only as national totals for different source types. We use a wide range of databases at the state, county, local, and point source level to disaggregate the inventory and allocate the spatial and temporal distribution of emissions for individual source types. Results show largemore » differences with the EDGAR v4.2 global gridded inventory commonly used as a priori estimate in inversions of atmospheric methane observations. We derive grid-dependent error statistics for individual source types from comparison with the Environmental Defense Fund (EDF) regional inventory for Northeast Texas. These error statistics are independently verified by comparison with the California Greenhouse Gas Emissions Measurement (CALGEM) grid-resolved emission inventory. Finally, our gridded, time-resolved inventory provides an improved basis for inversion of atmospheric methane observations to estimate US methane emissions and interpret the results in terms of the underlying processes.« less

Gridded National Inventory of U.S. Methane Emissions.

PubMed

Maasakkers, Joannes D; Jacob, Daniel J; Sulprizio, Melissa P; Turner, Alexander J; Weitz, Melissa; Wirth, Tom; Hight, Cate; DeFigueiredo, Mark; Desai, Mausami; Schmeltz, Rachel; Hockstad, Leif; Bloom, Anthony A; Bowman, Kevin W; Jeong, Seongeun; Fischer, Marc L

2016-12-06

We present a gridded inventory of US anthropogenic methane emissions with 0.1° × 0.1° spatial resolution, monthly temporal resolution, and detailed scale-dependent error characterization. The inventory is designed to be consistent with the 2016 US Environmental Protection Agency (EPA) Inventory of US Greenhouse Gas Emissions and Sinks (GHGI) for 2012. The EPA inventory is available only as national totals for different source types. We use a wide range of databases at the state, county, local, and point source level to disaggregate the inventory and allocate the spatial and temporal distribution of emissions for individual source types. Results show large differences with the EDGAR v4.2 global gridded inventory commonly used as a priori estimate in inversions of atmospheric methane observations. We derive grid-dependent error statistics for individual source types from comparison with the Environmental Defense Fund (EDF) regional inventory for Northeast Texas. These error statistics are independently verified by comparison with the California Greenhouse Gas Emissions Measurement (CALGEM) grid-resolved emission inventory. Our gridded, time-resolved inventory provides an improved basis for inversion of atmospheric methane observations to estimate US methane emissions and interpret the results in terms of the underlying processes.

Use of stable isotope signatures to determine mercury sources in the Great Lakes

USGS Publications Warehouse

Lepak, Ryan F.; Yin, Runsheng; Krabbenhoft, David P.; Ogorek, Jacob M.; DeWild, John F.; Holsen, Thomas M.; Hurley, James P.

2015-01-01

Sources of mercury (Hg) in Great Lakes sediments were assessed with stable Hg isotope ratios using multicollector inductively coupled plasma mass spectrometry. An isotopic mixing model based on mass-dependent (MDF) and mass-independent fractionation (MIF) (δ202Hg and Δ199Hg) identified three primary Hg sources for sediments: atmospheric, industrial, and watershed-derived. Results indicate atmospheric sources dominate in Lakes Huron, Superior, and Michigan sediments while watershed-derived and industrial sources dominate in Lakes Erie and Ontario sediments. Anomalous Δ200Hg signatures, also apparent in sediments, provided independent validation of the model. Comparison of Δ200Hg signatures in predatory fish from three lakes reveals that bioaccumulated Hg is more isotopically similar to atmospherically derived Hg than a lake’s sediment. Previous research suggests Δ200Hg is conserved during biogeochemical processing and odd mass-independent fractionation (MIF) is conserved during metabolic processing, so it is suspected even is similarly conserved. Given these assumptions, our data suggest that in some cases, atmospherically derived Hg may be a more important source of MeHg to higher trophic levels than legacy sediments in the Great Lakes.

[Quantitative estimation source of urban atmospheric CO2 by carbon isotope composition].

PubMed

Liu, Wei; Wei, Nan-Nan; Wang, Guang-Hua; Yao, Jian; Zeng, You-Shi; Fan, Xue-Bo; Geng, Yan-Hong; Li, Yan

2012-04-01

To effectively reduce urban carbon emissions and verify the effectiveness of currently project for urban carbon emission reduction, quantitative estimation sources of urban atmospheric CO2 correctly is necessary. Since little fractionation of carbon isotope exists in the transportation from pollution sources to the receptor, the carbon isotope composition can be used for source apportionment. In the present study, a method was established to quantitatively estimate the source of urban atmospheric CO2 by the carbon isotope composition. Both diurnal and height variations of concentrations of CO2 derived from biomass, vehicle exhaust and coal burning were further determined for atmospheric CO2 in Jiading district of Shanghai. Biomass-derived CO2 accounts for the largest portion of atmospheric CO2. The concentrations of CO2 derived from the coal burning are larger in the night-time (00:00, 04:00 and 20:00) than in the daytime (08:00, 12:00 and 16:00), and increase with the increase of height. Those derived from the vehicle exhaust decrease with the height increase. The diurnal and height variations of sources reflect the emission and transport characteristics of atmospheric CO2 in Jiading district of Shanghai.

Glacial influence on the geochemistry of riverine iron fluxes to the Gulf of Alaska and effects of deglaciation

USGS Publications Warehouse

Schroth, A.W.; Crusius, John; Chever, F.; Bostick, B.C.; Rouxel, O.J.

2011-01-01

Riverine iron (Fe) derived from glacial weathering is a critical micronutrient source to ecosystems of the Gulf of Alaska (GoA). Here we demonstrate that the source and chemical nature of riverine Fe input to the GoA could change dramatically due to the widespread watershed deglaciation that is underway. We examine Fe size partitioning, speciation, and isotopic composition in tributaries of the Copper River which exemplify a long-term GoA watershed evolution from one strongly influenced by glacial weathering to a boreal-forested watershed. Iron fluxes from glacierized tributaries bear high suspended sediment and colloidal Fe loads of mixed valence silicate species, with low concentrations of dissolved Fe and dissolved organic carbon (DOC). Iron isotopic composition is indicative of mechanical weathering as the Fe source. Conversely, Fe fluxes from boreal-forested systems have higher dissolved Fe concentrations corresponding to higher DOC concentrations. Iron colloids and suspended sediment consist of Fe (hydr)oxides and organic complexes. These watersheds have an iron isotopic composition indicative of an internal chemical processing source. We predict that as the GoA watershed evolves due to deglaciation, so will the source, flux, and chemical nature of riverine Fe loads, which could have significant ramifications for Alaskan marine and freshwater ecosystems.

Augmented classical least squares multivariate spectral analysis

DOEpatents

Haaland, David M.; Melgaard, David K.

2004-02-03

A method of multivariate spectral analysis, termed augmented classical least squares (ACLS), provides an improved CLS calibration model when unmodeled sources of spectral variation are contained in a calibration sample set. The ACLS methods use information derived from component or spectral residuals during the CLS calibration to provide an improved calibration-augmented CLS model. The ACLS methods are based on CLS so that they retain the qualitative benefits of CLS, yet they have the flexibility of PLS and other hybrid techniques in that they can define a prediction model even with unmodeled sources of spectral variation that are not explicitly included in the calibration model. The unmodeled sources of spectral variation may be unknown constituents, constituents with unknown concentrations, nonlinear responses, non-uniform and correlated errors, or other sources of spectral variation that are present in the calibration sample spectra. Also, since the various ACLS methods are based on CLS, they can incorporate the new prediction-augmented CLS (PACLS) method of updating the prediction model for new sources of spectral variation contained in the prediction sample set without having to return to the calibration process. The ACLS methods can also be applied to alternating least squares models. The ACLS methods can be applied to all types of multivariate data.

Augmented Classical Least Squares Multivariate Spectral Analysis

DOEpatents

Haaland, David M.; Melgaard, David K.

2005-07-26

A method of multivariate spectral analysis, termed augmented classical least squares (ACLS), provides an improved CLS calibration model when unmodeled sources of spectral variation are contained in a calibration sample set. The ACLS methods use information derived from component or spectral residuals during the CLS calibration to provide an improved calibration-augmented CLS model. The ACLS methods are based on CLS so that they retain the qualitative benefits of CLS, yet they have the flexibility of PLS and other hybrid techniques in that they can define a prediction model even with unmodeled sources of spectral variation that are not explicitly included in the calibration model. The unmodeled sources of spectral variation may be unknown constituents, constituents with unknown concentrations, nonlinear responses, non-uniform and correlated errors, or other sources of spectral variation that are present in the calibration sample spectra. Also, since the various ACLS methods are based on CLS, they can incorporate the new prediction-augmented CLS (PACLS) method of updating the prediction model for new sources of spectral variation contained in the prediction sample set without having to return to the calibration process. The ACLS methods can also be applied to alternating least squares models. The ACLS methods can be applied to all types of multivariate data.

Augmented Classical Least Squares Multivariate Spectral Analysis

DOEpatents

Haaland, David M.; Melgaard, David K.

2005-01-11

A method of multivariate spectral analysis, termed augmented classical least squares (ACLS), provides an improved CLS calibration model when unmodeled sources of spectral variation are contained in a calibration sample set. The ACLS methods use information derived from component or spectral residuals during the CLS calibration to provide an improved calibration-augmented CLS model. The ACLS methods are based on CLS so that they retain the qualitative benefits of CLS, yet they have the flexibility of PLS and other hybrid techniques in that they can define a prediction model even with unmodeled sources of spectral variation that are not explicitly included in the calibration model. The unmodeled sources of spectral variation may be unknown constituents, constituents with unknown concentrations, nonlinear responses, non-uniform and correlated errors, or other sources of spectral variation that are present in the calibration sample spectra. Also, since the various ACLS methods are based on CLS, they can incorporate the new prediction-augmented CLS (PACLS) method of updating the prediction model for new sources of spectral variation contained in the prediction sample set without having to return to the calibration process. The ACLS methods can also be applied to alternating least squares models. The ACLS methods can be applied to all types of multivariate data.

A correction function method for the wave equation with interface jump conditions

NASA Astrophysics Data System (ADS)

Abraham, David S.; Marques, Alexandre Noll; Nave, Jean-Christophe

2018-01-01

In this paper a novel method to solve the constant coefficient wave equation, subject to interface jump conditions, is presented. In general, such problems pose issues for standard finite difference solvers, as the inherent discontinuity in the solution results in erroneous derivative information wherever the stencils straddle the given interface. Here, however, the recently proposed Correction Function Method (CFM) is used, in which correction terms are computed from the interface conditions, and added to affected nodes to compensate for the discontinuity. In contrast to existing methods, these corrections are not simply defined at affected nodes, but rather generalized to a continuous function within a small region surrounding the interface. As a result, the correction function may be defined in terms of its own governing partial differential equation (PDE) which may be solved, in principle, to arbitrary order of accuracy. The resulting scheme is not only arbitrarily high order, but also robust, having already seen application to Poisson problems and the heat equation. By extending the CFM to this new class of PDEs, the treatment of wave interface discontinuities in homogeneous media becomes possible. This allows, for example, for the straightforward treatment of infinitesimal source terms and sharp boundaries, free of staircasing errors. Additionally, new modifications to the CFM are derived, allowing compatibility with explicit multi-step methods, such as Runge-Kutta (RK4), without a reduction in accuracy. These results are then verified through numerous numerical experiments in one and two spatial dimensions.

Energy/dissipation-preserving Birkhoffian multi-symplectic methods for Maxwell's equations with dissipation terms

DOE PAGES

Su, Hongling; Li, Shengtai

2016-02-03

In this study, we propose two new energy/dissipation-preserving Birkhoffian multi-symplectic methods (Birkhoffian and Birkhoffian box) for Maxwell's equations with dissipation terms. After investigating the non-autonomous and autonomous Birkhoffian formalism for Maxwell's equations with dissipation terms, we first apply a novel generating functional theory to the non-autonomous Birkhoffian formalism to propose our Birkhoffian scheme, and then implement a central box method to the autonomous Birkhoffian formalism to derive the Birkhoffian box scheme. We have obtained four formal local conservation laws and three formal energy global conservation laws. We have also proved that both of our derived schemes preserve the discrete versionmore » of the global/local conservation laws. Furthermore, the stability, dissipation and dispersion relations are also investigated for the schemes. Theoretical analysis shows that the schemes are unconditionally stable, dissipation-preserving for Maxwell's equations in a perfectly matched layer (PML) medium and have second order accuracy in both time and space. Numerical experiments for problems with exact theoretical results are given to demonstrate that the Birkhoffian multi-symplectic schemes are much more accurate in preserving energy than both the exponential finite-difference time-domain (FDTD) method and traditional Hamiltonian scheme. Finally, we also solve the electromagnetic pulse (EMP) propagation problem and the numerical results show that the Birkhoffian scheme recovers the magnitude of the current source and reaction history very well even after long time propagation.« less

Energy/dissipation-preserving Birkhoffian multi-symplectic methods for Maxwell's equations with dissipation terms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Hongling; Li, Shengtai

In this study, we propose two new energy/dissipation-preserving Birkhoffian multi-symplectic methods (Birkhoffian and Birkhoffian box) for Maxwell's equations with dissipation terms. After investigating the non-autonomous and autonomous Birkhoffian formalism for Maxwell's equations with dissipation terms, we first apply a novel generating functional theory to the non-autonomous Birkhoffian formalism to propose our Birkhoffian scheme, and then implement a central box method to the autonomous Birkhoffian formalism to derive the Birkhoffian box scheme. We have obtained four formal local conservation laws and three formal energy global conservation laws. We have also proved that both of our derived schemes preserve the discrete versionmore » of the global/local conservation laws. Furthermore, the stability, dissipation and dispersion relations are also investigated for the schemes. Theoretical analysis shows that the schemes are unconditionally stable, dissipation-preserving for Maxwell's equations in a perfectly matched layer (PML) medium and have second order accuracy in both time and space. Numerical experiments for problems with exact theoretical results are given to demonstrate that the Birkhoffian multi-symplectic schemes are much more accurate in preserving energy than both the exponential finite-difference time-domain (FDTD) method and traditional Hamiltonian scheme. Finally, we also solve the electromagnetic pulse (EMP) propagation problem and the numerical results show that the Birkhoffian scheme recovers the magnitude of the current source and reaction history very well even after long time propagation.« less

Improving Photometry and Stellar Signal Preservation with Pixel-Level Systematic Error Correction

NASA Technical Reports Server (NTRS)

Kolodzijczak, Jeffrey J.; Smith, Jeffrey C.; Jenkins, Jon M.

2013-01-01

The Kepler Mission has demonstrated that excellent stellar photometric performance can be achieved using apertures constructed from optimally selected CCD pixels. The clever methods used to correct for systematic errors, while very successful, still have some limitations in their ability to extract long-term trends in stellar flux. They also leave poorly correlated bias sources, such as drifting moiré pattern, uncorrected. We will illustrate several approaches where applying systematic error correction algorithms to the pixel time series, rather than the co-added raw flux time series, provide significant advantages. Examples include, spatially localized determination of time varying moiré pattern biases, greater sensitivity to radiation-induced pixel sensitivity drops (SPSDs), improved precision of co-trending basis vectors (CBV), and a means of distinguishing the stellar variability from co-trending terms even when they are correlated. For the last item, the approach enables physical interpretation of appropriately scaled coefficients derived in the fit of pixel time series to the CBV as linear combinations of various spatial derivatives of the pixel response function (PRF). We demonstrate that the residuals of a fit of soderived pixel coefficients to various PRF-related components can be deterministically interpreted in terms of physically meaningful quantities, such as the component of the stellar flux time series which is correlated with the CBV, as well as, relative pixel gain, proper motion and parallax. The approach also enables us to parameterize and assess the limiting factors in the uncertainties in these quantities.

Tracking nonpoint source nitrogen pollution in human-impacted watersheds

USGS Publications Warehouse

Kaushal, Sujay S.; Groffman, Peter M; Band, Lawrence; Elliott, Emily M.; Shields, Catherine A.; Kendall, Carol

2011-01-01

Nonpoint source nitrogen (N) pollution is a leading contributor to U.S. water quality impairments. We combined watershed N mass balances and stable isotopes to investigate fate and transport of nonpoint N in forest, agricultural, and urbanized watersheds at the Baltimore Long-Term Ecological Research site. Annual N retention was 55%, 68%, and 82% for agricultural, suburban, and forest watersheds, respectively. Analysis of δ15N-NO3–, and δ18O-NO3– indicated wastewater was an important nitrate source in urbanized streams during baseflow. Negative correlations between δ15N-NO3– and δ18O-NO3– in urban watersheds indicated mixing between atmospheric deposition and wastewater, and N source contributions changed with storm magnitude (atmospheric sources contributed ∼50% at peak storm N loads). Positive correlations between δ15N-NO3– and δ18O-NO3– in watersheds suggested denitrification was removing septic system and agriculturally derived N, but N from belowground leaking sewers was less susceptible to denitrification. N transformations were also observed in a storm drain (no natural drainage network) potentially due to organic carbon inputs. Overall, nonpoint sources such as atmospheric deposition, wastewater, and fertilizer showed different susceptibility to watershed N export. There were large changes in nitrate sources as a function of runoff, and anticipating source changes in response to climate and storms will be critical for managing nonpoint N pollution.

Finite Moment Tensors of Southern California Earthquakes

NASA Astrophysics Data System (ADS)

Jordan, T. H.; Chen, P.; Zhao, L.

2003-12-01

We have developed procedures for inverting broadband waveforms for the finite moment tensors (FMTs) of regional earthquakes. The FMT is defined in terms of second-order polynomial moments of the source space-time function and provides the lowest order representation of a finite fault rupture; it removes the fault-plane ambiguity of the centroid moment tensor (CMT) and yields several additional parameters of seismological interest: the characteristic length L{c}, width W{c}, and duration T{c} of the faulting, as well as the directivity vector {v}{d} of the fault slip. To formulate the inverse problem, we follow and extend the methods of McGuire et al. [2001, 2002], who have successfully recovered the second-order moments of large earthquakes using low-frequency teleseismic data. We express the Fourier spectra of a synthetic point-source waveform in its exponential (Rytov) form and represent the observed waveform relative to the synthetic in terms two frequency-dependent differential times, a phase delay δ τ {p}(ω ) and an amplitude-reduction time δ τ {q}(ω ), which we measure using Gee and Jordan's [1992] isolation-filter technique. We numerically calculate the FMT partial derivatives in terms of second-order spatiotemporal gradients, which allows us to use 3D finite-difference seismograms as our isolation filters. We have applied our methodology to a set of small to medium-sized earthquakes in Southern California. The errors in anelastic structure introduced perturbations larger than the signal level caused by finite source effect. We have therefore employed a joint inversion technique that recovers the CMT parameters of the aftershocks, as well as the CMT and FMT parameters of the mainshock, under the assumption that the source finiteness of the aftershocks can be ignored. The joint system of equations relating the δ τ {p} and δ τ {q} data to the source parameters of the mainshock-aftershock cluster is denuisanced for path anomalies in both observables; this projection operation effectively corrects the mainshock data for path-related amplitude anomalies in a way similar to, but more flexible than, empirical Green function (EGF) techniques.

Volatiles in the Earth and Moon: Constraints on planetary formation and evolution

NASA Astrophysics Data System (ADS)

Parai, Rita

The volatile inventories of the Earth and Moon reflect unique histories of volatile acquisition and loss in the early Solar System. The terrestrial volatile inventory was established after the giant impact phase of accretion, and the planet subsequently settled into a regime of long-term volatile exchange between the mantle and surface reservoirs in association with plate tectonics. Therefore, volatiles in the Earth and Moon shed light on a diverse array of processes that shaped planetary bodies in the Solar System as they evolved to their present-day states. Here we investigate new constraints on volatile depletion in the early Solar System, early outgassing of the terrestrial mantle, and the long-term evolution of the deep Earth volatile budget. We develop a Monte Carlo model of long-term water exchange between the mantle and surface reservoirs. Previous estimates of the deep Earth return flux of water are up to an order of magnitude too large, and incorporation of recycled slabs on average rehydrates the upper mantle but dehydrates the plume source. We find evidence for heterogeneous recycling of atmospheric argon and xenon into the upper mantle from noble gases in Southwest Indian Ridge basalts. Xenon isotope systematics indicate that xenon budgets of mid-ocean ridge and plume-related mantle sources are dominated by recycled atmospheric xenon, though the two sources have experienced different degrees of degassing. Differences between the mid-ocean ridge and plume sources were initiated within the first 100 million years of Earth history, and the two sources have never subsequently been homogenized. New high-precision xenon isotopic data contribute to an emerging portrait of two mantle reservoirs with distinct histories of outgassing and incorporation of recycled material in association with plate tectonics. Xenon isotopes indicate that the Moon likely formed within ˜70 million years of the start of the Solar System. To further investigate early Solar System chronology, we determined strontium isotopic compositions in a suite of planetary materials. If the Moon is derived from proto-Earth material, then rubidium-strontium systematics in the lunar anorthosite 60025 and Moore County plagioclase indicate that Moon formation occurred within ~62 million years of the start of the Solar System.

A novel integrated approach for the hazardous radioactive dust source terms estimation in future nuclear fusion power plants.

PubMed

Poggi, L A; Malizia, A; Ciparisse, J F; Gaudio, P

2016-10-01

An open issue still under investigation by several international entities working on the safety and security field for the foreseen nuclear fusion reactors is the estimation of source terms that are a hazard for the operators and public, and for the machine itself in terms of efficiency and integrity in case of severe accident scenarios. Source term estimation is a crucial key safety issue to be addressed in the future reactors safety assessments, and the estimates available at the time are not sufficiently satisfactory. The lack of neutronic data along with the insufficiently accurate methodologies used until now, calls for an integrated methodology for source term estimation that can provide predictions with an adequate accuracy. This work proposes a complete methodology to estimate dust source terms starting from a broad information gathering. The wide number of parameters that can influence dust source term production is reduced with statistical tools using a combination of screening, sensitivity analysis, and uncertainty analysis. Finally, a preliminary and simplified methodology for dust source term production prediction for future devices is presented.

Molecular characteristics of continuously released DOM during one year of root and leaf litter decomposition

NASA Astrophysics Data System (ADS)

Altmann, Jens; Jansen, Boris; Kalbitz, Karsten; Filley, Timothy

2013-04-01

Dissolved organic matter (DOM) is one of the most dynamic carbon pools linking the terrestrial with the aquatic carbon cycle. Besides the insecure contribution of terrestrial DOM to the greenhouse effect, DOM also plays an important role for the mobility and availability of heavy metals and organic pollutants in soils. These processes depend very much on the molecular characteristics of the DOM. Surprisingly the processes that determine the molecular composition of DOM are only poorly understood. DOM can originate from various sources, which influence its molecular composition. It has been recognized that DOM formation is not a static process and DOM characteristics vary not only between different carbon sources. However, molecular characteristics of DOM extracts have scarcely been studied continuously over a longer period of time. Due to constant molecular changes of the parent litter material or soil organic matter during microbial degradation, we assumed that also the molecular characteristics of litter derived DOM varies at different stages during root and needle decomposition. For this study we analyzed the chemical composition of root and leaf samples of 6 temperate tree species during one year of litter decomposition in a laboratory incubation. During this long-term experiment we measured continuously carbon and nitrogen contents of the water extracts and the remaining residues, C mineralization rates, and the chemical composition of water extracts and residues by Curie-point pyrolysis mass spectrometry with TMAH We focused on the following questions: (I) How mobile are molecules derived from plant polymers like tannin, lignin, suberin and cutin? (II) How does the composition of root and leaf derived DOM change over time in dependence on the stage of decomposition and species? Litter derived DOM was generally dominated by aromatic compounds. Substituded fatty acids as typically cutin or suberin derived were not detected in the water extracts. Fresh leaf and needle samples released a much higher amount of tannins than fresh root samples. At later litter decomposition stages the influence of tannins decreased and lignin derived phenols dominated the extracts. With ongoing litter degradation the degree of oxidation for the litter material increased, which was also reflected by the water extracted molecules.

Digestion and Absorption of Carbohydrates

USDA-ARS?s Scientific Manuscript database

Carbohydrates are the major dietary sources of energy for humans. While most dietary carbohydrates are derived from multiple botanical sources, lactose and trehalose are the only animal-derived carbohydrates. Digestion of starch, the carbohydrate most abundantly consumed by humans, depends on the c...

Magnitudes and Sources of Catchment Sediment: When A + B Doesn't Equal C

NASA Astrophysics Data System (ADS)

Simon, A.

2015-12-01

The export of land-based sediments to receiving waters can cause degradation of water quality and habitat, loss of reservoir capacity and damage to reef ecosystems. Predictions of sources and magnitudes generally come from simulations using catchment models that focus on overland flow processes at the expense of gully and channel processes. This is not appropriate for many catchments where recent research has shown that the dominant erosion sources have shifted from the uplands and fields following European Settlement, to the alluvial valleys today. Still, catchment models which fail to adequately address channel and bank processes are still the overwhelming choice by resource agencies to help manage sediment export. These models often utilize measured values of sediment load at the river mouth to "calibrate" the magnitude of loads emanating from uplands and fields. The difference between the sediment load at the mouth and the simulated upland loading is then proportioned to channel sources.Bank erosion from the Burnett River (a "Reef Catchment" in eastern Queensland) was quantified by comparisons of bank-top locations and by numerical modeling using BSTEM. Results show that bank-derived sediment contributes between 44 and 73% of the sediment load being exported to the Coral Sea. In comparison reported results from a catchment model showed bank contributions of 8%. In absolute terms, this is an increase in the reported average, annual rate of bank erosion from 0.175 Mt/y to 2.0 Mt/y.In the Hoteo River, New Zealand, a rural North Island catchment characterized by resistant cohesive sediments, bank erosion was found to contribute at least 48% of the total specific yield of sediment. Combining the bank-derived, fine-grained loads from some of the major tributaries gives a total, average annual loading rate for fine material of about 10,900 t/y for the studied reaches in the Hoteo River System. If the study was extended to include the lower reaches of the main stem channel and other tributary reaches, this percentage would be higher. Similar studies in the United States using combinations of empirical and numerical modeling techniques have also disclosed that bank-derived sediment can be the major source of sediment in many catchments. An approach to improve the accuracy of predictions is proposed.

Shining light on modifications of gravity

NASA Astrophysics Data System (ADS)

Brax, Philippe; Burrage, Clare; Davis, Anne-Christine

2012-10-01

Many modifications of gravity introduce new scalar degrees of freedom, and in such theories matter fields typically couple to an effective metric that depends on both the true metric of spacetime and on the scalar field and its derivatives. Scalar field contributions to the effective metric can be classified as conformal and disformal. Disformal terms introduce gradient couplings between scalar fields and the energy momentum tensor of other matter fields, and cannot be constrained by fifth force experiments because the effects of these terms are trivial around static non-relativistic sources. The use of high-precision, low-energy photon experiments to search for conformally coupled scalar fields, called axion-like particles, is well known. In this article we show that these experiments are also constraining for disformal scalar field theories, and are particularly important because of the difficulty of constraining these couplings with other laboratory experiments.

Year-round Regional CO2 Fluxes from Boreal and Tundra Ecosystems in Alaska

NASA Astrophysics Data System (ADS)

Commane, R.; Lindaas, J.; Benmergui, J. S.; Luus, K. A.; Chang, R. Y. W.; Daube, B. C.; Euskirchen, E. S.; Henderson, J.; Karion, A.; Miller, J. B.; Miller, S. M.; Parazoo, N.; Randerson, J. T.; Sweeney, C.; Tans, P. P.; Thoning, K. W.; Veraverbeke, S.; Miller, C. E.; Wofsy, S. C.

2016-12-01

High-latitude ecosystems could release large amounts of carbon dioxide (CO2) to the atmosphere in a warmer climate. We derive temporally and spatially resolved year-round CO2 fluxes in Alaska from a synthesis of airborne and tower CO2 observations in 2012-2014. We find that tundra ecosystems were net sources of atmospheric CO2. We discuss these flux estimates in the context of long-term CO2 measurements at Barrow, AK, to asses the long term trend in carbon fluxes in the Arctic. Many Earth System Models incorrectly simulate net carbon uptake in Alaska presently. Our results imply that annual net emission of CO2 to the atmosphere may have increased markedly in this region of the Arctic in response to warming climate, supporting the view that climate-carbon feedback is strongly positive in the high Arctic.

[PRECHORDAL AND MYOEPICARDIAL PLATES: TERMINOLOGICAL ASPECTS, THE PROBLEMS OF DEFINITION].

PubMed

Korolyov, V A; Pototskaya, O Yu

2015-01-01

Most accurately, the prechordal plate (PCP) can be defined as the zone of close contact of cells of endodermal epithelium and mesenchyme in the region between the oropharyngeal membrane and the notochord. This structure is involved in the induction of the anterior parts of the brain and, in particular, the pituitary gland, as well as in the formation of some of eye muscles and bones of the skull base (chordal chondrocranium). Further studies are needed to clarify PCP involvement in the development of pharynx, esophagus, and their derivatives, as well as to determine the source and the mechanisms of development of PCP mesenchymal cells. The term "prechordal plate" should not be confused with the Spemann's organizer, head organizer, oropharyngeal membrane, mesendoderm, head process and the prechordal mesoderm, which is common in the scientific literature. The term "myoepicardial plate" falsely indicates the common origin of myocardium and epicardium, thus its usage should be avoided.

A kinetic model for the transport of electrons in a graphene layer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fermanian Kammerer, Clotilde, E-mail: Clotilde.Fermanian@u-pec.fr; Méhats, Florian, E-mail: florian.mehats@univ-rennes1.fr

In this article, we propose a new numerical scheme for the computation of the transport of electrons in a graphene device. The underlying quantum model for graphene is a massless Dirac equation, whose eigenvalues display a conical singularity responsible for non-adiabatic transitions between the two modes. We first derive a kinetic model which takes the form of two Boltzmann equations coupled by a collision operator modeling the non-adiabatic transitions. This collision term includes a Landau–Zener transfer term and a jump operator whose presence is essential in order to ensure a good energy conservation during the transitions. We propose an algorithmicmore » realization of the semi-group solving the kinetic model, by a particle method. We give analytic justification of the model and propose a series of numerical experiments studying the influences of the various sources of errors between the quantum and the kinetic models.« less

Quantitative determination of vinpocetine in dietary supplements

PubMed Central

French, John M. T.; King, Matthew D.

2017-01-01

Current United States regulatory policies allow for the addition of pharmacologically active substances in dietary supplements if derived from a botanical source. The inclusion of certain nootropic drugs, such as vinpocetine, in dietary supplements has recently come under scrutiny due to the lack of defined dosage parameters and yet unproven short- and long-term benefits and risks to human health. This study quantified the concentration of vinpocetine in several commercially available dietary supplements and found that a highly variable range of 0.6–5.1 mg/serving was present across the tested products, with most products providing no specification of vinpocetine concentrations. PMID:27319129

(U) An Analytic Study of Piezoelectric Ejecta Mass Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tregillis, Ian Lee

2017-02-16

We consider the piezoelectric measurement of the areal mass of an ejecta cloud, for the specific case where ejecta are created by a single shock at the free surface and fly ballistically through vacuum to the sensor. To do so, we define time- and velocity-dependent ejecta “areal mass functions” at the source and sensor in terms of typically unknown distribution functions for the ejecta particles. Next, we derive an equation governing the relationship between the areal mass function at the source (which resides in the rest frame of the free surface) and at the sensor (which resides in the laboratorymore » frame). We also derive expressions for the analytic (“true”) accumulated ejecta mass at the sensor and the measured (“inferred”) value obtained via the standard method for analyzing piezoelectric voltage traces. This approach enables us to derive an exact expression for the error imposed upon a piezoelectric ejecta mass measurement (in a perfect system) by the assumption of instantaneous creation. We verify that when the ejecta are created instantaneously (i.e., when the time dependence is a delta function), the piezoelectric inference method exactly reproduces the correct result. When creation is not instantaneous, the standard piezo analysis will always overestimate the true mass. However, the error is generally quite small (less than several percent) for most reasonable velocity and time dependences. In some cases, errors exceeding 10-15% may require velocity distributions or ejecta production timescales inconsistent with experimental observations. These results are demonstrated rigorously with numerous analytic test problems.« less

Ergot alkaloids: From witchcraft till in silico analysis. Multi-receptor analysis of ergotamine metabolites.

PubMed

Dellafiora, Luca; Dall'Asta, Chiara; Cozzini, Pietro

2015-01-01

The term Ergot is referred to the sclerotium of ascomycetes - a protective kernel produced during resting stage of some fungi - which replaces seeds of susceptible cereals and plants intended for human and animal diet. It contains various composition of tryptophan-derived toxins defined ergot alkaloids. Since sclerotia can be harvested and milled together with cereals, they represent a source of food and feed contamination after breakage and spreading of mycotoxins into the various milling fractions. The effects of ergot alkaloids, including those adverse for human health, have been known since the Middle Ages. Nevertheless, as recently stated by the European Food Safety Authority, further information is needed on metabolism and target receptors-binding of common alkaloids in food. Unfortunately, the experimental investigation is challenging due to the high costs in terms of time and money. This study was thus aimed at assessing whether the in silico modeling can be an effective tool to investigate the interaction between multiple serotonin receptors and a wide set of ergotamine metabolites, including experimentally detected molecules and predicted derivatives. Validated models provided precious insights about the effects exerted by metabolic modifications on the receptor-ligand interaction. Such structural information may be useful to support the design of further experimental analysis.

Non-Markovian quantum Brownian motion in one dimension in electric fields

NASA Astrophysics Data System (ADS)

Shen, H. Z.; Su, S. L.; Zhou, Y. H.; Yi, X. X.

2018-04-01

Quantum Brownian motion is the random motion of quantum particles suspended in a field (or an effective field) resulting from their collision with fast-moving modes in the field. It provides us with a fundamental model to understand various physical features concerning open systems in chemistry, condensed-matter physics, biophysics, and optomechanics. In this paper, without either the Born-Markovian or rotating-wave approximation, we derive a master equation for a charged-Brownian particle in one dimension coupled with a thermal reservoir in electric fields. The effect of the reservoir and the electric fields is manifested as time-dependent coefficients and coherent terms, respectively, in the master equation. The two-photon correlation between the Brownian particle and the reservoir can induce nontrivial squeezing dynamics to the particle. We derive a current equation including the source from the driving fields, transient current from the system flowing into the environment, and the two-photon current caused by the non-rotating-wave term. The presented results then are compared with that given by the rotating-wave approximation in the weak-coupling limit, and these results are extended to a more general quantum network involving an arbitrary number of coupled-Brownian particles. The presented formalism might open a way to better understand exactly the non-Markovian quantum network.

Development of an epiphyte indicator of nutrient enrichment ...

EPA Pesticide Factsheets

Metrics of epiphyte load on macrophytes were evaluated for use as quantitative biological indicators for nutrient impacts in estuarine waters, based on review and analysis of the literature on epiphytes and macrophytes, primarily seagrasses, but including some brackish and freshwater rooted macrophyte species. An approach is presented that empirically derives threshold epiphyte loads which are likely to cause specified levels of decrease in macrophyte response metrics such as biomass, shoot density, percent cover, production and growth. Data from 36 studies of 10 macrophyte species were pooled to derive relationships between epiphyte load and -25 and -50% seagrass response levels, which are proposed as the primary basis for establishment of critical threshold values. Given multiple sources of variability in the response data, threshold ranges based on the range of values falling between the median and the 75th quantiles of observations at a given seagrass response level are proposed rather than single, critical point values. Four epiphyte load threshold categories - low, moderate, high, very high, are proposed. Comparison of values of epiphyte loads associated with 25 and 50% reductions in light to macrophytes suggest that the threshold ranges are realistic both in terms of the principle mechanism of impact to macrophytes and in terms of the magnitude of resultant impacts expressed by the macrophytes. Some variability in response levels was observed among

Compilation of a Global Emission Inventory from 1980 to 2000 for Global Model Simulations of the Long-term Trend of Tropospheric Aerosols

NASA Technical Reports Server (NTRS)

Diehl, T. L.; Mian, Chin; Bond, T. C.; Carn, S. A.; Duncan, B. N.; Krotkov, N. A.; Streets, D. G.

2007-01-01

The approach to create a comprehensive emission inventory for the time period 1980 to 2000 is described in this paper. We have recently compiled an emission database, which we will use for a 21 year simulation of tropospheric aerosols with the GOCART model. Particular attention was paid to the time-dependent SO2, black carbon and organic carbon aerosol emissions. For the emission of SO2 from sporadically erupting volcanoes, we assembled emission data from the Global Volcanism Program of the Smithsonian Institution, using the VEI to derive the volcanic cloud height and the SO2 amount, and amended this dataset by the SO2 emission data from the TOMS instrument when available. 3-dimensional aircraft emission data was obtained for a number of years from the AEAP project, converted from burned fuel to SO2 and interpolated to each year, taking the sparsity of the flight patterns into account. Other anthopogenic SO2 emissions are based on gridded emissions from the EDGAR 2000 database (excluding sources from aircraft, biomass burning and international ship traffic), which were scaled to individual years with country/regional based emission inventories. Gridded SO2 emissions from international ship traffic for 2000 and the scaling factors for other years are from [Eyring et al., 2005]. We used gridded anthropogenic black and organic carbon emissions for 1996 [Bond et al., 2005], again excluding aircraft, biomass burning and ship sources. These emissions were scaled with regional based emission inventories from 1980 to 2000 to derive gridded emissions for each year. The biomass burning emissions are based on a climatology, which is scaled with regional scaling factors derived from the TOMS aerosol index and the AVHRR/ATSR fire counts to each year [Duncan et al., 2003]. Details on the integration of the information from the various sources will be provided and the distribution patterns and total emissions in the final product will be discussed.

Compilation of a Global Emission Inventory from 1980 to 2000 for Global Model Simulations of the Long-term Trend of Tropospheric Aerosols

NASA Technical Reports Server (NTRS)

Diehl, Thomas L.; Chin, Mian; Bond, Tami C.; Carn, SImon A.; Duncan, Bryan N.; Krotkov, Nickolay A.; Streets, David G.

2006-01-01

The approach to create a comprehensive emission inventory for the time period 1980 to 2000 is described in this paper. We have recently compiled an emission database, which we will use for a 21 year simulation of tropospheric aerosols with the GOCART model. Particular attention was paid to the time-dependent SO2, black carbon and organic carbon aerosol emissions. For the emission of SO2 from sporadically erupting volcanoes, we assembled emission data from the Global Volcanism Program of the Smithsonian Institution, using the VEI to derive the volcanic cloud height and the SO2 amount, and amended this dataset by the SO2 emission data from the TOMS instrument when available. 3-dimensional aircraft emission data was obtained for a number of years from the AEAP project, converted from burned fuel to SO2 and interpolated to each year, taking the sparsity of the flight patterns into account. Other anthropogenic SO2 emissions are based on gridded emissions from the EDGAR 2000 database (excluding sources from aircraft, biomass burning and international ship traffic), which were scaled to individual years with country/regional based emission inventories. Gridded SO2 emissions from international ship traffic for 2000 and the scaling factors for other years are from [Eyring et al., 2005]. We used gridded anthropogenic black and organic carbon emissions for 1996 [Bond et al., 2005], again excluding aircraft, biomass burning and ship sources. These emissions were scaled with regional based emission inventories from 1980 to 2000 to derive gridded emissions for each year. The biomass burning emissions are based on a climatology, which is scaled with regional scaling factors derived from the TOMS aerosol index and the AVHRR/ASTR fire counts to each year [Duncan et al., 2003]. Details on the integration of the information from the various sources will be provided and the distribution patterns and total emissions in the final product will be discussed.

Mantle Sources and Origin of the Four Overlapping Continental LIPs Generated Throughout 2500 m.y. of Kaapvaal Craton History in Southern Africa

NASA Astrophysics Data System (ADS)

Ashwal, L. D.

2017-12-01

The Archean Kaapvaal Craton of southern Africa hosts at least four spatially overlapping Large Igneous Provinces (LIPs), each of which generated substantial volumes ( 1-3 x 106 km3) of mafic magmatic rocks, over short time intervals (5 m.y. or less), between 2.7 and 0.18 Ga: the Ventersdorp Supergroup (2714 Ma, 0.7 x 106 km3), the Bushveld layered intrusion (2056 Ma, 1.5 x 106 km3), the Umkondo Igneous Province (1105 Ma, 2 x 106 km3) and the Karoo LIP (182 Ma, 3 x 106 km3). Therefore, over a time interval of >2500 m.y., a minimum collective volume of 7.2 x 106 km3 of mantle-derived, mafic lavas, sills, dikes and derivative cumulate rocks, was periodically emplaced through, into and/or onto the same cratonic region of Archean lithosphere. This long-term spatial superposition of Kaapvaal LIPs can be used as input to the vigorous debate on the nature of LIP mantle sources, and the possible role of crustal contamination in their petrogenesis. Continental LIP magmas, including all four of the Kaapvaal examples, have commonly been interpreted as products of direct partial melting of sub-continental lithospheric mantle (SCLM) sources, with little or no contribution from upwelling, plume-related, asthenospheric materials that provided the heat for melting. The Kaapvaal SCLM was stabilized at 3 Ga by prior melt extraction events that rendered it chemically depleted, and hence buoyant; it seems unlikely that it might have been capable of generating 1-3 x 106 km3 of basaltic magmas four times during its history. This would require repeated, substantial refertilization to counteract the extensive chemical depletion caused by recurrent extraction of LIP magmas. Chemical enrichment events sufficient to yield such extensive volumes of basaltic magma would necessarily increase bulk SCLM density, compromising its long-term buoyancy and stability. It seems far more likely, therefore, that the Kaapvaal LIPs were generated from sub-lithospheric sources, and that their diverse geochemical and isotopic signatures represent variable assimilation of Archean (dominantly 3.0-3.6 Ga) granitoid crustal contaminants, as many have suggested. These arguments challenge the plausibility of SCLM melting as a viable general process for the origin of other continental LIPs.

Semiotic foundation for multisensor-multilook fusion

NASA Astrophysics Data System (ADS)

Myler, Harley R.

1998-07-01

This paper explores the concept of an application of semiotic principles to the design of a multisensor-multilook fusion system. Semiotics is an approach to analysis that attempts to process media in a united way using qualitative methods as opposed to quantitative. The term semiotic refers to signs, or signatory data that encapsulates information. Semiotic analysis involves the extraction of signs from information sources and the subsequent processing of the signs into meaningful interpretations of the information content of the source. The multisensor fusion problem predicated on a semiotic system structure and incorporating semiotic analysis techniques is explored and the design for a multisensor system as an information fusion system is explored. Semiotic analysis opens the possibility of using non-traditional sensor sources and modalities in the fusion process, such as verbal and textual intelligence derived from human observers. Examples of how multisensor/multimodality data might be analyzed semiotically is shown and discussion on how a semiotic system for multisensor fusion could be realized is outlined. The architecture of a semiotic multisensor fusion processor that can accept situational awareness data is described, although an implementation has not as yet been constructed.

Permeable Surface Corrections for Ffowcs Williams and Hawkings Integrals

NASA Technical Reports Server (NTRS)

Lockard, David P.; Casper, Jay H.

2005-01-01

The acoustic prediction methodology discussed herein applies an acoustic analogy to calculate the sound generated by sources in an aerodynamic simulation. Sound is propagated from the computed flow field by integrating the Ffowcs Williams and Hawkings equation on a suitable control surface. Previous research suggests that, for some applications, the integration surface must be placed away from the solid surface to incorporate source contributions from within the flow volume. As such, the fluid mechanisms in the input flow field that contribute to the far-field noise are accounted for by their mathematical projection as a distribution of source terms on a permeable surface. The passage of nonacoustic disturbances through such an integration surface can result in significant error in an acoustic calculation. A correction for the error is derived in the frequency domain using a frozen gust assumption. The correction is found to work reasonably well in several test cases where the error is a small fraction of the actual radiated noise. However, satisfactory agreement has not been obtained between noise predictions using the solution from a three-dimensional, detached-eddy simulation of flow over a cylinder.

The North Alabama Lightning Warning Product

NASA Technical Reports Server (NTRS)

Buechler, Dennis E.; Blakeslee, R. J.; Stano, G. T.

2009-01-01

The North Alabama Lightning Mapping Array NALMA has been collecting total lightning data on storms in the Tennessee Valley region since 2001. Forecasters from nearby National Weather Service (NWS) offices have been ingesting this data for display with other AWIPS products. The current lightning product used by the offices is the lightning source density plot. The new product provides a probabalistic, short-term, graphical forecast of the probability of lightning activity occurring at 5 min intervals over the next 30 minutes . One of the uses of the current lightning source density product by the Huntsville National Weather Service Office is to identify areas of potential for cloud-to-ground flashes based on where LMA total lightning is occurring. This product quantifies that observation. The Lightning Warning Product is derived from total lightning observations from the Washington, D.C. (DCLMA) and North Alabama Lightning Mapping Arrays and cloud-to-ground lightning flashes detected by the National Lightning Detection Network (NLDN). Probability predictions are provided for both intracloud and cloud-to-ground flashes. The gridded product can be displayed on AWIPS workstations in a manner similar to that of the lightning source density product.

Continuous fermentation of food waste leachate for the production of volatile fatty acids and potential as a denitrification carbon source.

PubMed

Kim, Hakchan; Kim, Jaai; Shin, Seung Gu; Hwang, Seokhwan; Lee, Changsoo

2016-05-01

This study investigated the simultaneous effects of hydraulic retention time (HRT) and pH on the continuous production of VFAs from food waste leachate using response surface analysis. The response surface approximations (R(2)=0.895, p<0.05) revealed that pH has a dominant effect on the specific VFA production (PTVFA) within the explored space (1-4-day HRT, pH 4.5-6.5). The estimated maximum PTVFA was 0.26g total VFAs/g CODf at 2.14-day HRT and pH 6.44, and the approximation was experimentally validated by running triplicate reactors under the estimated optimum conditions. The mixture of the filtrates recovered from these reactors was tested as a denitrification carbon source and demonstrated superior performance in terms of reaction rate and lag length relative to other chemicals, including acetate and methanol. The overall results provide helpful information for better design and control of continuous fermentation for producing waste-derived VFAs, an alternative carbon source for denitrification. Copyright © 2016 Elsevier Ltd. All rights reserved.

Wound Healing and Angiogenesis through Combined Use of a Vascularized Tissue Flap and Adipose-Derived Stem Cells in a Rat Hindlimb Irradiated Ischemia Model.

PubMed

Yoshida, Shuhei; Yoshimoto, Hiroshi; Hirano, Akiyoshi; Akita, Sadanori

2016-05-01

Treatment of critical limb ischemia is sometimes difficult because of the patient's condition, and some novel approaches are needed. The hindlimbs of Sprague-Dawley rats, after 20-Gy x-ray irradiation and surgical occlusion, were divided into four groups: with a superficial fascial flap, 5.0 × 10 adipose-derived stromal/stem cells, and both combined. The rats were tested for laser tissue blood flow, immunohistologic blood vessel density, and foot paw punch hole wound healing. Green fluorescent protein-tagged Sprague-Dawley rats were used for further investigation by cell tracking for 2 weeks. Laser tissue blood flow demonstrated a significant increase in the combined treatment of flap and adipose-derived stem cells at both 1 and 2 weeks. There were no significant differences between the treatment groups treated with flaps alone and those treated with adipose-derived stem cells alone. Wound healing was significantly increased following combined treatment at 1 week, and there was no wound by 2 weeks except for the no-flap and no-adipose-derived stem cell group. The number of vessels depicted by von Willebrand factor showed a significant increase in the combined treatment group, at both 1 week and 2 weeks. In the cell tracking group, at 2 weeks, the green fluorescent protein-tagged adipose-derived stem cells were significantly more positive in the no-flap group than in the flap group. Adipose-derived stem cells may be a potent cell source in irradiated and occluded limbs by enhancing tissue blood flow and blood vessel density. Adipose-derived stem cells may play an important role in some difficult ischemic conditions in terms of wound healing.

An analytical model of iceberg drift

NASA Astrophysics Data System (ADS)

Eisenman, I.; Wagner, T. J. W.; Dell, R.

2017-12-01

Icebergs transport freshwater from glaciers and ice shelves, releasing the freshwater into the upper ocean thousands of kilometers from the source. This influences ocean circulation through its effect on seawater density. A standard empirical rule-of-thumb for estimating iceberg trajectories is that they drift at the ocean surface current velocity plus 2% of the atmospheric surface wind velocity. This relationship has been observed in empirical studies for decades, but it has never previously been physically derived or justified. In this presentation, we consider the momentum balance for an individual iceberg, which includes nonlinear drag terms. Applying a series of approximations, we derive an analytical solution for the iceberg velocity as a function of time. In order to validate the model, we force it with surface velocity and temperature data from an observational state estimate and compare the results with iceberg observations in both hemispheres. We show that the analytical solution reduces to the empirical 2% relationship in the asymptotic limit of small icebergs (or strong winds), which approximately applies for typical Arctic icebergs. We find that the 2% value arises due to a term involving the drag coefficients for water and air and the densities of the iceberg, ocean, and air. In the opposite limit of large icebergs (or weak winds), which approximately applies for typical Antarctic icebergs with horizontal length scales greater than about 12 km, we find that the 2% relationship is not applicable and that icebergs instead move with the ocean current, unaffected by the wind. The two asymptotic regimes can be understood by considering how iceberg size influences the relative importance of the wind and ocean current drag terms compared with the Coriolis and pressure gradient force terms in the iceberg momentum balance.

Using Google Earth to Explore Multiple Data Sets and Plate Tectonic Concepts

NASA Astrophysics Data System (ADS)

Goodell, L. P.

2015-12-01

Google Earth (GE) offers an engaging and dynamic environment for exploration of earth science data. While GIS software offers higher-level analytical capability, it comes with a steep learning curve and complex interface that is not easy for the novice, and in many cases the instructor, to negotiate. In contrast, the intuitive interface of GE makes it easy for students to quickly become proficient in manipulating the globe and independently exploring relationships between multiple data sets at a wide range of scales. Inquiry-based, data-rich exercises have been developed for both introductory and upper-level activities including: exploration of plate boundary characteristics and relative motion across plate boundaries; determination and comparison of short-term and long-term average plate velocities; crustal strain analysis (modeled after the UNAVCO activity); and determining earthquake epicenters, body-wave magnitudes, and focal plane solutions. Used successfully in undergraduate course settings, for TA training and for professional development programs for middle and high school teachers, the exercises use the following GE data sets (with sources) that have been collected/compiled by the author and are freely available for non-commercial use: 1) tectonic plate boundaries and plate names (Bird, 2003 model); 2) real-time earthquakes (USGS); 3) 30 years of M>=5.0 earthquakes, plotted by depth (USGS); 4) seafloor age (Mueller et al., 1997, 2008); 5) location and age data for hot spot tracks (published literature); 6) Holocene volcanoes (Smithsonian Global Volcanism Program); 7) GPS station locations with links to times series (JPL, NASA, UNAVCO); 8) short-term motion vectors derived from GPS times series; 9) long-term average motion vectors derived from plate motion models (UNAVCO plate motion calculator); 10) earthquake data sets consisting of seismic station locations and links to relevant seismograms (Rapid Earthquake Viewer, USC/IRIS/DELESE).

THE FUNDAMENTAL SOLUTIONS FOR MULTI-TERM MODIFIED POWER LAW WAVE EQUATIONS IN A FINITE DOMAIN.

PubMed

Jiang, H; Liu, F; Meerschaert, M M; McGough, R J

2013-01-01

Fractional partial differential equations with more than one fractional derivative term in time, such as the Szabo wave equation, or the power law wave equation, describe important physical phenomena. However, studies of these multi-term time-space or time fractional wave equations are still under development. In this paper, multi-term modified power law wave equations in a finite domain are considered. The multi-term time fractional derivatives are defined in the Caputo sense, whose orders belong to the intervals (1, 2], [2, 3), [2, 4) or (0, n ) ( n > 2), respectively. Analytical solutions of the multi-term modified power law wave equations are derived. These new techniques are based on Luchko's Theorem, a spectral representation of the Laplacian operator, a method of separating variables and fractional derivative techniques. Then these general methods are applied to the special cases of the Szabo wave equation and the power law wave equation. These methods and techniques can also be extended to other kinds of the multi-term time-space fractional models including fractional Laplacian.

Capture Versus Capture Zones: Clarifying Terminology Related to Sources of Water to Wells.

PubMed

Barlow, Paul M; Leake, Stanley A; Fienen, Michael N

2018-03-15

The term capture, related to the source of water derived from wells, has been used in two distinct yet related contexts by the hydrologic community. The first is a water-budget context, in which capture refers to decreases in the rates of groundwater outflow and (or) increases in the rates of recharge along head-dependent boundaries of an aquifer in response to pumping. The second is a transport context, in which capture zone refers to the specific flowpaths that define the three-dimensional, volumetric portion of a groundwater flow field that discharges to a well. A closely related issue that has become associated with the source of water to wells is streamflow depletion, which refers to the reduction in streamflow caused by pumping, and is a type of capture. Rates of capture and streamflow depletion are calculated by use of water-budget analyses, most often with groundwater-flow models. Transport models, particularly particle-tracking methods, are used to determine capture zones to wells. In general, however, transport methods are not useful for quantifying actual or potential streamflow depletion or other types of capture along aquifer boundaries. To clarify the sometimes subtle differences among these terms, we describe the processes and relations among capture, capture zones, and streamflow depletion, and provide proposed terminology to distinguish among them. Published 2018. This article is a U.S. Government work and is in the public domain in the USA. Groundwater published by Wiley Periodicals, Inc. on behalf of National Ground Water Association.

Dendrochemical record of historical lead contamination sources, Wells G&H Superfund site, Woburn, Massachusetts.

PubMed

Burnett, Aaron; Kurtz, Andrew C; Brabander, Daniel; Shailer, Mark

2007-01-01

Laser-ablation inductively coupled-plasma mass-spectrometry analysis of red oak (Quercus rubra) from a well documented heavy metal contaminated United States Environmental Protection Agency superfund site in Woburn, Massachusetts reveals decade-long trends in Pb contaminant sources. Lead isotope ratios (207Pb/206Pb and 208Pb/206Pb) in tree rings plot along a linear trend bracketed by several local and regional contamination sources. Statistically significant interannual variations in 207Pb/206Pb suggest that atmospheric Pb is rapidly incorporated into wood, with minimal mobility subsequent to deposition in annual growth rings. We interpret the decadal trends in our record as a changing mixture of local pollution sources and gasoline-derived Pb. Between 1940 and 1970, Pb was predominantly derived from remobilization of local industrial Pb sources. An abrupt shift in 207Pb/206Pb may indicate that local Pb sources were overwhelmed by gasoline-derived Pb during the peak of leaded gasoline emissions in the late 1960s and early 1970s.

Molecular indicators for palaeoenvironmental change in a Messinian evaporitic sequence (Vena del Gesso, Italy). II: High-resolution variations in abundances and 13C contents of free and sulphur-bound carbon skeletons in a single marl bed

NASA Technical Reports Server (NTRS)

Kenig, F.; Damste, J. S.; Frewin, N. L.; Hayes, J. M.; De Leeuw, J. W.

1995-01-01

The extractable organic matter of 10 immature samples from a marl bed of one evaporitic cycle of the Vena del Gesso sediments (Gessoso-solfifera Fm., Messinian, Italy) was analyzed quantitatively for free hydrocarbons and organic sulphur compounds. Nickel boride was used as a desulphurizing agent to recover sulphur-bound lipids from the polar and asphaltene fractions. Carbon isotopic compositions (delta vs PDB) of free hydrocarbons and of S-bound hydrocarbons were also measured. Relationships between these carbon skeletons, precursor biolipids, and the organisms producing them could then be examined. Concentrations of S-bound lipids and free hydrocarbons and their delta values were plotted vs depth in the marl bed and the profiles were interpreted in terms of variations in source organisms, 13 C contents of the carbon source, and environmentally induced changes in isotopic fractionation. The overall range of delta values measured was 24.7%, from -11.6% for a component derived from green sulphur bacteria (Chlorobiaceae) to -36.3% for a lipid derived from purple sulphur bacteria (Chromatiaceae). Deconvolution of mixtures of components deriving from multiple sources (green and purple sulphur bacteria, coccolithophorids, microalgae and higher plants) was sometimes possible because both quantitative and isotopic data were available and because either the free or S-bound pool sometimes appeared to contain material from a single source. Several free n-alkanes and S-bound lipids appeared to be specific products of upper-water-column primary producers (i.e. algae and cyanobacteria). Others derived from anaerobic photoautotrophs and from heterotrophic protozoa (ciliates), which apparently fed partly on Chlorobiaceae. Four groups of n-alkanes produced by algae or cyanobacteria were also recognized based on systematic variations of abundance and isotopic composition with depth. For hydrocarbons probably derived from microalgae, isotopic variations are well correlated with those of total organic carbon. A resistant aliphatic biomacromolecule produced by microalgae is, therefore, probably an important component of the kerogen. These variations reflect changes in the depositional environment and early diagenetic transformations. Changes in the concentrations of S-bound lipids induced by variations in conditions favourable for sulphurization were discriminated from those related to variations in primary producer assemblages. The water column of the lagoonal basin was stratified and photic zone anoxia occurred during the early and middle stages of marl deposition. During the last stage of the marl deposition the stratification collapsed due to a significant shallowing of the water column. Contributions from anaerobic photoautotrophs were apparently associated with variations in depth of the chemocline.

Molecular indicators for palaeoenvironmental change in a Messinian evaporitic sequence (Vena del Gesso, Italy). II: High-resolution variations in abundances and 13C contents of free and sulphur-bound carbon skeletons in a single marl bed.

PubMed

Kenig, F; Damsté, J S; Frewin, N L; Hayes, J M; De Leeuw, J W

1995-06-01

The extractable organic matter of 10 immature samples from a marl bed of one evaporitic cycle of the Vena del Gesso sediments (Gessoso-solfifera Fm., Messinian, Italy) was analyzed quantitatively for free hydrocarbons and organic sulphur compounds. Nickel boride was used as a desulphurizing agent to recover sulphur-bound lipids from the polar and asphaltene fractions. Carbon isotopic compositions (delta vs PDB) of free hydrocarbons and of S-bound hydrocarbons were also measured. Relationships between these carbon skeletons, precursor biolipids, and the organisms producing them could then be examined. Concentrations of S-bound lipids and free hydrocarbons and their delta values were plotted vs depth in the marl bed and the profiles were interpreted in terms of variations in source organisms, 13 C contents of the carbon source, and environmentally induced changes in isotopic fractionation. The overall range of delta values measured was 24.7%, from -11.6% for a component derived from green sulphur bacteria (Chlorobiaceae) to -36.3% for a lipid derived from purple sulphur bacteria (Chromatiaceae). Deconvolution of mixtures of components deriving from multiple sources (green and purple sulphur bacteria, coccolithophorids, microalgae and higher plants) was sometimes possible because both quantitative and isotopic data were available and because either the free or S-bound pool sometimes appeared to contain material from a single source. Several free n-alkanes and S-bound lipids appeared to be specific products of upper-water-column primary producers (i.e. algae and cyanobacteria). Others derived from anaerobic photoautotrophs and from heterotrophic protozoa (ciliates), which apparently fed partly on Chlorobiaceae. Four groups of n-alkanes produced by algae or cyanobacteria were also recognized based on systematic variations of abundance and isotopic composition with depth. For hydrocarbons probably derived from microalgae, isotopic variations are well correlated with those of total organic carbon. A resistant aliphatic biomacromolecule produced by microalgae is, therefore, probably an important component of the kerogen. These variations reflect changes in the depositional environment and early diagenetic transformations. Changes in the concentrations of S-bound lipids induced by variations in conditions favourable for sulphurization were discriminated from those related to variations in primary producer assemblages. The water column of the lagoonal basin was stratified and photic zone anoxia occurred during the early and middle stages of marl deposition. During the last stage of the marl deposition the stratification collapsed due to a significant shallowing of the water column. Contributions from anaerobic photoautotrophs were apparently associated with variations in depth of the chemocline.

Scattering and; Delay, Scale, and Sum Migration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lehman, S K

How do we see? What is the mechanism? Consider standing in an open field on a clear sunny day. In the field are a yellow dog and a blue ball. From a wave-based remote sensing point of view the sun is a source of radiation. It is a broadband electromagnetic source which, for the purposes of this introduction, only the visible spectrum is considered (approximately 390 to 750 nanometers or 400 to 769 TeraHertz). The source emits an incident field into the known background environment which, for this example, is free space. The incident field propagates until it strikes anmore » object or target, either the yellow dog or the blue ball. The interaction of the incident field with an object results in a scattered field. The scattered field arises from a mis-match between the background refractive index, considered to be unity, and the scattering object refractive index ('yellow' for the case of the dog, and 'blue' for the ball). This is also known as an impedance mis-match. The scattering objects are referred to as secondary sources of radiation, that radiation being the scattered field which propagates until it is measured by the two receivers known as 'eyes'. The eyes focus the measured scattered field to form images which are processed by the 'wetware' of the brain for detection, identification, and localization. When time series representations of the measured scattered field are available, the image forming focusing process can be mathematically modeled by delayed, scaled, and summed migration. This concept of optical propagation, scattering, and focusing have one-to-one equivalents in the acoustic realm. This document is intended to present the basic concepts of scalar scattering and migration used in wide band wave-based remote sensing and imaging. The terms beamforming and (delayed, scaled, and summed) migration are used interchangeably but are to be distinguished from the narrow band (frequency domain) beamforming to determine the direction of arrival of a signal, and seismic migration in which wide band time series are shifted but not to form images per se. Section 3 presents a mostly graphically-based motivation and summary of delay, scale, and sum beamforming. The model for incident field propagation in free space is derived in Section 4 under specific assumptions. General object scattering is derived in Section 5 and simplified under the Born approximation in Section 6. The model of this section serves as the basis in the derivation of time-domain migration. The Foldy-Lax, full point scatterer scattering, method is derived in Section 7. With the previous forward models in hand, delay, scale, and sum beamforming is derived in Section 8. Finally, proof-of-principle experiments are present in Section 9.« less

Osmium Isotopic Evolution of the Mantle Sources of Precambrian Ultramafic Rocks

NASA Astrophysics Data System (ADS)

Gangopadhyay, A.; Walker, R. J.

2006-12-01

The Os isotopic composition of the modern mantle, as recorded collectively by ocean island basalts, mid- oceanic ridge basalts (MORB) and abyssal peridotites, is evidently highly heterogeneous (γ Os(I) ranging from <-10 to >+25). One important question, therefore, is how and when the Earth's mantle developed such large-scale Os isotopic heterogeneities. Previous Os isotopic studies of ancient ultramafic systems, including komatiites and picrites, have shown that the Os isotopic heterogeneity of the terrestrial mantle can be traced as far back as the late-Archean (~ 2.7-2.8 Ga). This observation is based on the initial Os isotopic ratios obtained for the mantle sources of some of the ancient ultramafic rocks determined through analyses of numerous Os-rich whole-rock and/or mineral samples. In some cases, the closed-system behavior of these ancient ultramafic rocks was demonstrated via the generation of isochrons of precise ages, consistent with those obtained from other radiogenic isotopic systems. Thus, a compilation of the published initial ^{187}Os/^{188}Os ratios reported for the mantle sources of komatiitic and picritic rocks is now possible that covers a large range of geologic time spanning from the Mesozoic (ca. 89 Ma Gorgona komatiites) to the Mid-Archean (e.g., ca. 3.3 Ga Commondale komatiites), which provides a comprehensive picture of the Os isotopic evolution of their mantle sources through geologic time. Several Precambrian komatiite/picrite systems are characterized by suprachondritic initial ^{187}Os/^{188}Os ratios (e.g., Belingwe, Kostomuksha, Pechenga). Such long-term enrichments in ^{187}Os of the mantle sources for these rocks may be explained via recycling of old mafic oceanic crust or incorporation of putative suprachondritic outer core materials entrained into their mantle sources. The relative importance of the two processes for some modern mantle-derived systems (e.g., Hawaiian picrites) is an issue of substantial debate. Importantly, however, the high-precision initial Os isotopic compositions of the majority of ultramafic systems show strikingly uniform initial ^{187}Os/^{188}Os ratios, consistent with their derivation from sources that had Os isotopic evolution trajectory very similar to that of carbonaceous chondrites. In addition, the Os isotopic evolution trajectories of the mantle sources for most komatiites show resolvably lower average Re/Os than that estimated for the Primitive Upper Mantle (PUM), yet significantly higher than that obtained in some estimates for the modern convecting upper mantle, as determined via analyses of abyssal peridotites. One possibility is that most of the komatiites sample mantle sources that are unique relative to the sources of abyssal peridotites and MORB. Previous arguments that komatiites originate via large extents of partial melting of relatively deep upper mantle, or even lower mantle materials could, therefore, implicate a source that is different from the convecting upper mantle. If so, this source is remarkably uniform in its long-term Re/Os, and it shows moderate depletion in Re relative to the PUM. Alternatively, if the komatiites are generated within the convective upper mantle through relatively large extents of partial melting, they may provide a better estimate of the Os isotopic composition of the convective upper mantle than that obtained via analyses of MORB, abyssal peridotites and ophiolites.

Induced pluripotent stem cells (iPSCs) derived from different cell sources and their potential for regenerative and personalized medicine.

PubMed

Shtrichman, R; Germanguz, I; Itskovitz-Eldor, J

2013-06-01

Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biological characteristics of iPSCs are not yet fully understood and their similarity to human embryonic stem cells (hESCs) is still unresolved. Variations among iPSCs, resulting from their original tissue or cell source, and from the experimental protocols used for their derivation, significantly affect epigenetic properties and differentiation potential. Here we review the potential of iPSCs for regenerative and personalized medicine, and assess their expression pattern, epigenetic memory and differentiation capabilities in relation to their parental tissue source. We also summarize the patient-specific iPSCs that have been derived for applications in biological research and drug discovery; and review risks that must be overcome in order to use iPSC technology for clinical applications.

Comparative Chondrogenesis of Human Cell Sources in 3D Scaffolds

PubMed Central

Tıg̑lı, R. Seda; Ghosh, Sourabh; Laha, Michael M.; Shevde, Nirupama K.; Daheron, Laurence; Gimble, Jeffrey; Gümüşdereliog̑lu, Menemşe; Kaplan, David L.

2009-01-01

Cartilage tissue can be engineered by starting from a diversity of cell sources, including stem-cell based and primary cell-based platforms. Selecting an appropriate cell source for the process of cartilage tissue engineering or repair is critical and challenging due to the variety of cell options available. In this study, cellular responses of isolated human chondrocytes, human embryonic stem cells and mesenchymal stem cells (MSCs) derived from three sources, human embryonic stem cells, bone marrow and adipose tissue, were assessed for chondrogenic potential in 3D culture. All cell sources were characterized by FACS analysis to compare expression of some surface markers. The cells were differentiated in two different biomaterial matrices, silk and chitosan scaffolds, in the presence and absence of bone morphogenetic protein 6 (BMP-6) along with the standard chondrogenic differentiating factors. Embryonic stem cells derived MSCs showed unique characteristics with preserved chondrogenic phenotype in both scaffolds with regard to chondrogenesis, as determined by real time RT-PCR, histological and microscopic analyses. After 4 weeks of cultivation, embryonic stem cells derived MSCs were promising for chondrogenesis, particularly in the silk scaffolds with BMP-6. The results suggest that cell source differences are important to consider with regard to chondrogenic outcomes and with the variables addressed here, the human embryonic stem cells derived MSCs were the preferred cell source. PMID:19382119

Higher derivatives in Type II and M-theory on Calabi-Yau threefolds

NASA Astrophysics Data System (ADS)

Grimm, Thomas W.; Mayer, Kilian; Weissenbacher, Matthias

2018-02-01

The four- and five-dimensional effective actions of Calabi-Yau threefold compactifications are derived with a focus on terms involving up to four space-time derivatives. The starting points for these reductions are the ten- and eleven-dimensional supergravity actions supplemented with the known eight-derivative corrections that have been inferred from Type II string amplitudes. The corrected background solutions are determined and the fluctuations of the Kähler structure of the compact space and the form-field back-ground are discussed. It is concluded that the two-derivative effective actions for these fluctuations only takes the expected supergravity form if certain additional ten- and eleven-dimensional higher-derivative terms for the form-fields are included. The main results on the four-derivative terms include a detailed treatment of higher-derivative gravity coupled to Kähler structure deformations. This is supplemented by a derivation of the vector sector in reductions to five dimensions. While the general result is only given as an expansion in the fluctuations, a complete treatment of the one-Kähler modulus case is presented for both Type II theories and M-theory.

Early and long-term mantle processing rates derived from xenon isotopes

NASA Astrophysics Data System (ADS)

Mukhopadhyay, S.; Parai, R.; Tucker, J.; Middleton, J. L.; Langmuir, C. H.

2015-12-01

Noble gases, particularly xenon (Xe), in mantle-derived basalts provide a rich portrait of mantle degassing and surface-interior volatile exchange. The combination of extinct and extant radioactive species in the I-Pu-U-Xe systems shed light on the degassing history of the early Earth throughout accretion, as well as the long-term degassing of the Earth's interior in association with plate tectonics. The ubiquitous presence of shallow-level air contamination, however, frequently obscures the mantle Xe signal. In a majority of the samples, shallow air contamination dominates the Xe budget. For example, in the gas-rich popping rock 2ΠD43, 129Xe/130Xe ratios reach 7.7±0.23 in individual step-crushes, but the bulk composition of the sample is close to air (129Xe/130Xe of 6.7). Thus, the extent of variability in mantle source Xe composition is not well-constrained. Here, we present new MORB Xe data and explore constraints placed on mantle processing rates by the Xe data. Ten step-crushes were obtained on a depleted popping glass that was sealed in ultrapure N2 after dredge retrieval from between the Kane-Atlantis Fracture Zone of the Mid Atlantic Ridge in May 2012. 9 steps yielded 129Xe/130Xe of 7.50-7.67 and one yielded 7.3. The bulk 129Xe/130Xe of the sample is 7.6, nearly identical to the estimated mantle source value of 7.7 for the sample. Hence, the sample is virtually free of shallow-level air contamination. Because sealing the sample in N2upon dredge retrieval largely eliminated air contamination, for many samples, contamination must be added after sample retrieval from the ocean bottom. Our new high-precision Xe isotopic measurements in upper mantle-derived samples provide improved constraints on the Xe isotopic composition of the mantle source. We developed a forward model of mantle volatile evolution to identify solutions that satisfy our Xe isotopic data. We find that accretion timescales of ~10±5 Myr are consistent with I-Pu-Xe constraints, and the last giant impact occurred 45-70 Myr after the start of the solar system. After the giant impact stage, the Pu-U-Xe system indicates that degassing of the planet via solid-state mantle convection and plate tectonics continued to liberate volatiles to the atmosphere and has led to between ~5-8 mantle turnovers over the age of the Earth.

Engineering description of the ascent/descent bet product

NASA Technical Reports Server (NTRS)

Seacord, A. W., II

1986-01-01

The Ascent/Descent output product is produced in the OPIP routine from three files which constitute its input. One of these, OPIP.IN, contains mission specific parameters. Meteorological data, such as atmospheric wind velocities, temperatures, and density, are obtained from the second file, the Corrected Meteorological Data File (METDATA). The third file is the TRJATTDATA file which contains the time-tagged state vectors that combine trajectory information from the Best Estimate of Trajectory (BET) filter, LBRET5, and Best Estimate of Attitude (BEA) derived from IMU telemetry. Each term in the two output data files (BETDATA and the Navigation Block, or NAVBLK) are defined. The description of the BETDATA file includes an outline of the algorithm used to calculate each term. To facilitate describing the algorithms, a nomenclature is defined. The description of the nomenclature includes a definition of the coordinate systems used. The NAVBLK file contains navigation input parameters. Each term in NAVBLK is defined and its source is listed. The production of NAVBLK requires only two computational algorithms. These two algorithms, which compute the terms DELTA and RSUBO, are described. Finally, the distribution of data in the NAVBLK records is listed.

Gravitational lens optical scalars in terms of energy-momentum distributions in the cosmological framework

NASA Astrophysics Data System (ADS)

Boero, Ezequiel F.; Moreschi, Osvaldo M.

2018-04-01

We present new results on gravitational lensing over cosmological Robertson-Walker backgrounds which extend and generalize previous works. Our expressions show the presence of new terms and factors which have been neglected in the literature on the subject. The new equations derived here for the optical scalars allow to deal with more general matter content including sources with non-Newtonian components of the energy-momentum tensor and arbitrary motion. Our treatment is within the framework of weak gravitational lenses in which first-order effects of the curvature are considered. We have been able to make all calculations without referring to the concept of deviation angle. This in turn, makes the presentation shorter but also allows for the consideration of global effects on the Robertson-Walker background that have been neglected in the literature. We also discuss two intensity magnifications that we define in this article; one coming from a natural geometrical construction in terms of the affine distance, that we here call \\tilde{μ }, and the other adapted to cosmological discussions in terms of the redshift, that we call μ΄. We show that the natural intensity magnification \\tilde{μ } coincides with the standard angular magnification (μ).

Nodal Green’s Function Method Singular Source Term and Burnable Poison Treatment in Hexagonal Geometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

A.A. Bingham; R.M. Ferrer; A.M. ougouag

2009-09-01

An accurate and computationally efficient two or three-dimensional neutron diffusion model will be necessary for the development, safety parameters computation, and fuel cycle analysis of a prismatic Very High Temperature Reactor (VHTR) design under Next Generation Nuclear Plant Project (NGNP). For this purpose, an analytical nodal Green’s function solution for the transverse integrated neutron diffusion equation is developed in two and three-dimensional hexagonal geometry. This scheme is incorporated into HEXPEDITE, a code first developed by Fitzpatrick and Ougouag. HEXPEDITE neglects non-physical discontinuity terms that arise in the transverse leakage due to the transverse integration procedure application to hexagonal geometry andmore » cannot account for the effects of burnable poisons across nodal boundaries. The test code being developed for this document accounts for these terms by maintaining an inventory of neutrons by using the nodal balance equation as a constraint of the neutron flux equation. The method developed in this report is intended to restore neutron conservation and increase the accuracy of the code by adding these terms to the transverse integrated flux solution and applying the nodal Green’s function solution to the resulting equation to derive a semi-analytical solution.« less

77 FR 19740 - Water Sources for Long-Term Recirculation Cooling Following a Loss-of-Coolant Accident

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

... NUCLEAR REGULATORY COMMISSION [NRC-2010-0249] Water Sources for Long-Term Recirculation Cooling... Regulatory Guide (RG) 1.82, ``Water Sources for Long-Term Recirculation Cooling Following a Loss-of-Coolant... regarding the sumps and suppression pools that provide water sources for emergency core cooling, containment...

Spectral performance of a whole-body research photon counting detector CT: quantitative accuracy in derived image sets

NASA Astrophysics Data System (ADS)

Leng, Shuai; Zhou, Wei; Yu, Zhicong; Halaweish, Ahmed; Krauss, Bernhard; Schmidt, Bernhard; Yu, Lifeng; Kappler, Steffen; McCollough, Cynthia

2017-09-01

Photon-counting computed tomography (PCCT) uses a photon counting detector to count individual photons and allocate them to specific energy bins by comparing photon energy to preset thresholds. This enables simultaneous multi-energy CT with a single source and detector. Phantom studies were performed to assess the spectral performance of a research PCCT scanner by assessing the accuracy of derived images sets. Specifically, we assessed the accuracy of iodine quantification in iodine map images and of CT number accuracy in virtual monoenergetic images (VMI). Vials containing iodine with five known concentrations were scanned on the PCCT scanner after being placed in phantoms representing the attenuation of different size patients. For comparison, the same vials and phantoms were also scanned on 2nd and 3rd generation dual-source, dual-energy scanners. After material decomposition, iodine maps were generated, from which iodine concentration was measured for each vial and phantom size and compared with the known concentration. Additionally, VMIs were generated and CT number accuracy was compared to the reference standard, which was calculated based on known iodine concentration and attenuation coefficients at each keV obtained from the U.S. National Institute of Standards and Technology (NIST). Results showed accurate iodine quantification (root mean square error of 0.5 mgI/cc) and accurate CT number of VMIs (percentage error of 8.9%) using the PCCT scanner. The overall performance of the PCCT scanner, in terms of iodine quantification and VMI CT number accuracy, was comparable to that of EID-based dual-source, dual-energy scanners.

Maternal intake of cashew nuts accelerates reflex maturation and facilitates memory in the offspring.

PubMed

de Melo, Marília Ferreira Frazão Tavares; Pereira, Diego Elias; Sousa, Morgana Moura; Medeiros, Dilian Maise Ferreira; Lemos, Leanderson Tulio Marques; Madruga, Marta Suely; Santos, Nayane Medeiros; de Oliveira, Maria Elieidy Gomes; de Menezes, Camila Carolina; Soares, Juliana Késsia Barbosa

2017-10-01

Essential fatty acids, being indispensable during the stages of pregnancy, lactation and infancy influence the transmission of nerve impulses and brain function, and cashew nuts are a good source of these fatty acids. The objective of this study was to evaluate the effects of cashew nut consumption on reflex development, memory and profile of fatty acids of rat offspring treated during pregnancy and lactation. The animals were divided into three groups: Control (CONT), treated with 7% lipid derived from soybean oil; Normolipidic (NL) treated with 7% lipids derived from cashew nuts; and Hyperlipidic (HL) treated with 20% lipids derived from cashew nuts. Reflex ontogeny, Open-field habituation test and the Object Recognition Test (ORT) were assessed. The profile of fatty acids in the brain was carried out when the animals were zero, 21 and 60days old. Accelerated reflex maturation was observed in animals treated with cashew nuts (p<0.05). NL presented better memory in the Open-field habituation test; the NL and HL showed improvement of short-term memory in the ORT, but long term damage in HL (p<0.05). The results of the lipid profile of the brain at the end of the experiment showed an increase in levels of saturated fatty acids and less Docosahexaenoic acid (DHA) in animals of the HL. The data showed that maternal consumption of cashew nuts can accelerate reflex maturation and facilitate memory in offspring when offered in adequate quantities. Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.

Combustion of dried animal dung as biofuel results in the generation of highly redox active fine particulates

PubMed Central

Mudway, Ian S; Duggan, Sean T; Venkataraman, Chandra; Habib, Gazala; Kelly, Frank J; Grigg, Jonathan

2005-01-01

Background The burning of biomass in the developing world for heating and cooking results in high indoor particle concentrations. Long-term exposure to airborne particulate matter (PM) has been associated with increased rates of acute respiratory infections, chronic obstructive lung disease and cancer. In this study we determined the oxidative activity of combustion particles derived from the biomass fuel dung cake by examining their capacity to deplete antioxidants from a model human respiratory tract lining fluid (RTLF). For comparison, the observed oxidative activity was compared with that of particles derived from industrial and vehicular sources. Results Incubation of the dung cake particle suspensions in the RTLF for 4 h resulted in a mean loss of ascorbate of 72.1 ± 0.7 and 89.7 ± 2.5% at 50 and 100 μg/ml, respectively. Reduced glutathione was depleted by 49.6 ± 4.3 and 63.5 ± 22.4% under the same conditions. The capacity of these samples to deplete ascorbate was in excess of that observed with diesel or gasoline particles, but comparable to that seen with residual oil fly ash and considerably in excess of all three control particles in terms of glutathione depletion. Co-incubation with the metal chelator diethylenetriaminepentaacetate inhibited these losses, whilst minimal inhibition was seen with superoxide dismutase and catalase treatment. The majority of the activity observed appeared to be contained within aqueous particle extracts. Conclusion These data demonstrate that biomass derived particles have considerable oxidative activity, largely attributable to their transition metal content. PMID:16202154

Depletion and capture: revisiting "the source of water derived from wells".

PubMed

Konikow, L F; Leake, S A

2014-09-01

A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion and capture relative to groundwater withdrawals (extraction or pumpage) have not previously been well characterized. This study assesses the partitioning of long-term cumulative withdrawal volumes into fractions derived from storage depletion and capture, where capture includes both increases in recharge and decreases in discharge. Numerical simulation of a hypothetical groundwater basin is used to further illustrate some of Theis' (1940) principles, particularly when capture is constrained by insufficient available water. Most prior studies of depletion and capture have assumed that capture is unconstrained through boundary conditions that yield linear responses. Examination of real systems indicates that capture and depletion fractions are highly variable in time and space. For a large sample of long-developed groundwater systems, the depletion fraction averages about 0.15 and the capture fraction averages about 0.85 based on cumulative volumes. Higher depletion fractions tend to occur in more arid regions, but the variation is high and the correlation coefficient between average annual precipitation and depletion fraction for individual systems is only 0.40. Because 85% of long-term pumpage is derived from capture in these real systems, capture must be recognized as a critical factor in assessing water budgets, groundwater storage depletion, and sustainability of groundwater development. Most capture translates into streamflow depletion, so it can detrimentally impact ecosystems. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Vitamin B12-Containing Plant Food Sources for Vegetarians

PubMed Central

Watanabe, Fumio; Yabuta, Yukinori; Bito, Tomohiro; Teng, Fei

2014-01-01

The usual dietary sources of Vitamin B12 are animal-derived foods, although a few plant-based foods contain substantial amounts of Vitamin B12. To prevent Vitamin B12 deficiency in high-risk populations such as vegetarians, it is necessary to identify plant-derived foods that contain high levels of Vitamin B12. A survey of naturally occurring plant-derived food sources with high Vitamin B12 contents suggested that dried purple laver (nori) is the most suitable Vitamin B12 source presently available for vegetarians. Furthermore, dried purple laver also contains high levels of other nutrients that are lacking in vegetarian diets, such as iron and n-3 polyunsaturated fatty acids. Dried purple laver is a natural plant product and it is suitable for most people in various vegetarian groups. PMID:24803097

The impact of the form of the Euler equations for radial flow in cylindrical and spherical coordinates on numerical conservation and accuracy

NASA Astrophysics Data System (ADS)

Crittenden, P. E.; Balachandar, S.

2018-07-01

The radial one-dimensional Euler equations are often rewritten in what is known as the geometric source form. The differential operator is identical to the Cartesian case, but source terms result. Since the theory and numerical methods for the Cartesian case are well-developed, they are often applied without modification to cylindrical and spherical geometries. However, numerical conservation is lost. In this article, AUSM^+-up is applied to a numerically conservative (discrete) form of the Euler equations labeled the geometric form, a nearly conservative variation termed the geometric flux form, and the geometric source form. The resulting numerical methods are compared analytically and numerically through three types of test problems: subsonic, smooth, steady-state solutions, Sedov's similarity solution for point or line-source explosions, and shock tube problems. Numerical conservation is analyzed for all three forms in both spherical and cylindrical coordinates. All three forms result in constant enthalpy for steady flows. The spatial truncation errors have essentially the same order of convergence, but the rate constants are superior for the geometric and geometric flux forms for the steady-state solutions. Only the geometric form produces the correct shock location for Sedov's solution, and a direct connection between the errors in the shock locations and energy conservation is found. The shock tube problems are evaluated with respect to feature location using an approximation with a very fine discretization as the benchmark. Extensions to second order appropriate for cylindrical and spherical coordinates are also presented and analyzed numerically. Conclusions are drawn, and recommendations are made. A derivation of the steady-state solution is given in the Appendix.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parworth, Caroline; Fast, Jerome D.; Mei, Fan

In this study the long-term trends of non-refractory submicrometer aerosol (NR-PM1) composition and mass concentration measured by an Aerosol Chemical Speciation Monitor (ACSM) at the U.S. Department of Energy’s Southern Great Plains (SGP) site are discussed. Over the period of 19 months (Nov. 20, 2010 – June 2012) highly time resolved (~30 min.) NR-PM1 data was recorded. Using this dataset the value-added product (VAP) of deriving organic aerosol components (OACOMP) is introduced. With this VAP, multivariate analysis of the measured organic mass spectral matrix can be performed on long term data to return organic aerosol (OA) factors that are associatedmore » with distinct sources, evolution processes, and physiochemical properties. Three factors were obtained from this VAP including two oxygenated OA (OOA) factors, differing in degrees of oxidation, and a biomass burning OA (BBOA) factor. Back trajectory analyses were performed to investigate possible sources of major NR-PM1 species at the SGP site. Organics dominated NR-PM1 mass concentration for the majority of the study with the exception of winter, when nitrate increased due to transport of precursor species from surrounding urban and agricultural areas and also due to cooler temperatures. Sulfate mass concentrations showed little seasonal variation with mixed regional and local sources. In the spring BBOA emissions increased and were mainly associated with local fires. Isoprene and carbon monoxide emission rates were computed by the Model of Emissions of Gases and Aerosols from Nature (MEGAN) to represent the spatial distribution of biogenic and anthropogenic sources, respectively. From this model there is evidence to support that biogenic emissions from the southeast contribute to SOA formation at the SGP site during the summer.« less

Point-particle effective field theory I: classical renormalization and the inverse-square potential

NASA Astrophysics Data System (ADS)

Burgess, C. P.; Hayman, Peter; Williams, M.; Zalavári, László

2017-04-01

Singular potentials (the inverse-square potential, for example) arise in many situations and their quantum treatment leads to well-known ambiguities in choosing boundary conditions for the wave-function at the position of the potential's singularity. These ambiguities are usually resolved by developing a self-adjoint extension of the original prob-lem; a non-unique procedure that leaves undetermined which extension should apply in specific physical systems. We take the guesswork out of this picture by using techniques of effective field theory to derive the required boundary conditions at the origin in terms of the effective point-particle action describing the physics of the source. In this picture ambiguities in boundary conditions boil down to the allowed choices for the source action, but casting them in terms of an action provides a physical criterion for their determination. The resulting extension is self-adjoint if the source action is real (and involves no new degrees of freedom), and not otherwise (as can also happen for reasonable systems). We show how this effective-field picture provides a simple framework for understanding well-known renormalization effects that arise in these systems, including how renormalization-group techniques can resum non-perturbative interactions that often arise, particularly for non-relativistic applications. In particular we argue why the low-energy effective theory tends to produce a universal RG flow of this type and describe how this can lead to the phenomenon of reaction catalysis, in which physical quantities (like scattering cross sections) can sometimes be surprisingly large compared to the underlying scales of the source in question. We comment in passing on the possible relevance of these observations to the phenomenon of the catalysis of baryon-number violation by scattering from magnetic monopoles.

Priority substances in sediments of the "Carska Bara" special nature reserve, a natural scientific research area on the UNESCO list.

PubMed

Grba, Nenad; Krčmar, Dejan; Isakovski, Marijana Kragulj; Jazić, Jelena Molnar; Maletić, Snežana; Pešić, Vesna; Dalmacija, Božo

2016-11-01

Surface sediments were subject to systematic long-term monitoring (2002-2014) in the Republic of Serbia (Province of Vojvodina). Eight heavy metals (Ni, Zn, Cd, Cr, Cu, Pb, As and Hg), mineral oils (total petroleum hydrocarbons), 16 EPA PAHs, selected pesticides and polychlorinated biphenyls (PCB) were monitored. As part of this research, this paper presents a sediment contamination spatial and temporal trend study of diverse pollution sources and the ecological risk status of the alluvial sediments of Carska Bara at three representative sampling sites (S1S3), in order to establish the status of contamination and recommend substances of interest for more widespread future monitoring. Multivariate statistical methods including factor analysis of principal component analysis (PCA/FA), Pearson correlation and several synthetic indicators were used to evaluate the extent and origin of contamination (anthropogenic or natural, geogenic sources) and potential ecological risks. Hg, Cd, As, mineral oils and PAHs (dominated by dibenzo(a,h)anthracene and benzo(a)pyrene, contributing 85.7% of the total) are derived from several anthropogenic sources, whereas Ni, Cu, Cr and Zn are convincingly of geogenic origin, and exhibit dual origins. Cd and Hg significantly raise the levels of potential ecological risk for all sampling locations, demonstrating the effect of long-term bioaccumulation and biomagnification. Pb is isolated from the other parameters, implying unique sources. This research suggests four heavy metals (Zn, Cr, Cu and As) and dibenzo(a,h)anthracene be added to the list of priority pollutants within the context of the application of the European Water Framework Directive (WFD), in accordance with significant national and similar environmental data from countries in the region. Copyright © 2016 Elsevier Ltd. All rights reserved.

The impact of the form of the Euler equations for radial flow in cylindrical and spherical coordinates on numerical conservation and accuracy

NASA Astrophysics Data System (ADS)

Crittenden, P. E.; Balachandar, S.

2018-03-01

The radial one-dimensional Euler equations are often rewritten in what is known as the geometric source form. The differential operator is identical to the Cartesian case, but source terms result. Since the theory and numerical methods for the Cartesian case are well-developed, they are often applied without modification to cylindrical and spherical geometries. However, numerical conservation is lost. In this article, AUSM^+ -up is applied to a numerically conservative (discrete) form of the Euler equations labeled the geometric form, a nearly conservative variation termed the geometric flux form, and the geometric source form. The resulting numerical methods are compared analytically and numerically through three types of test problems: subsonic, smooth, steady-state solutions, Sedov's similarity solution for point or line-source explosions, and shock tube problems. Numerical conservation is analyzed for all three forms in both spherical and cylindrical coordinates. All three forms result in constant enthalpy for steady flows. The spatial truncation errors have essentially the same order of convergence, but the rate constants are superior for the geometric and geometric flux forms for the steady-state solutions. Only the geometric form produces the correct shock location for Sedov's solution, and a direct connection between the errors in the shock locations and energy conservation is found. The shock tube problems are evaluated with respect to feature location using an approximation with a very fine discretization as the benchmark. Extensions to second order appropriate for cylindrical and spherical coordinates are also presented and analyzed numerically. Conclusions are drawn, and recommendations are made. A derivation of the steady-state solution is given in the Appendix.

A primer on theory-driven web scraping: Automatic extraction of big data from the Internet for use in psychological research.

PubMed

Landers, Richard N; Brusso, Robert C; Cavanaugh, Katelyn J; Collmus, Andrew B

2016-12-01

The term big data encompasses a wide range of approaches of collecting and analyzing data in ways that were not possible before the era of modern personal computing. One approach to big data of great potential to psychologists is web scraping, which involves the automated collection of information from webpages. Although web scraping can create massive big datasets with tens of thousands of variables, it can also be used to create modestly sized, more manageable datasets with tens of variables but hundreds of thousands of cases, well within the skillset of most psychologists to analyze, in a matter of hours. In this article, we demystify web scraping methods as currently used to examine research questions of interest to psychologists. First, we introduce an approach called theory-driven web scraping in which the choice to use web-based big data must follow substantive theory. Second, we introduce data source theories , a term used to describe the assumptions a researcher must make about a prospective big data source in order to meaningfully scrape data from it. Critically, researchers must derive specific hypotheses to be tested based upon their data source theory, and if these hypotheses are not empirically supported, plans to use that data source should be changed or eliminated. Third, we provide a case study and sample code in Python demonstrating how web scraping can be conducted to collect big data along with links to a web tutorial designed for psychologists. Fourth, we describe a 4-step process to be followed in web scraping projects. Fifth and finally, we discuss legal, practical and ethical concerns faced when conducting web scraping projects. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Impacts of supersymmetric higher derivative terms on inflation models in supergravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aoki, Shuntaro; Yamada, Yusuke, E-mail: shun-soccer@akane.waseda.jp, E-mail: yuusuke-yamada@asagi.waseda.jp

2015-07-01

We show the effects of supersymmetric higher derivative terms on inflation models in supergravity. The results show that such terms generically modify the effective kinetic coefficient of the inflaton during inflation if the cut off scale of the higher derivative operators is sufficiently small. In such a case, the η-problem in supergravity does not occur, and we find that the effective potential of the inflaton generically becomes a power type potential with a power smaller than two.

On the high Mach number shock structure singularity caused by overreach of Maxwellian molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myong, R. S., E-mail: myong@gnu.ac.kr

2014-05-15

The high Mach number shock structure singularity arising in moment equations of the Boltzmann equation was investigated. The source of the singularity is shown to be the unbalanced treatment between two high order kinematic and dissipation terms caused by the overreach of Maxwellian molecule assumption. In compressive gaseous flow, the high order stress-strain coupling term of quadratic nature will grow far faster than the strain term, resulting in an imbalance with the linear dissipation term and eventually a blow-up singularity in high thermal nonequilibrium. On the other hand, the singularity arising from unbalanced treatment does not occur in the casemore » of velocity shear and expansion flows, since the high order effects are cancelled under the constraint of the free-molecular asymptotic behavior. As an alternative method to achieve the balanced treatment, Eu's generalized hydrodynamics, consistent with the second law of thermodynamics, was revisited. After introducing the canonical distribution function in exponential form and applying the cumulant expansion to the explicit calculation of the dissipation term, a natural platform suitable for the balanced treatment was derived. The resulting constitutive equation with the nonlinear factor was then shown to be well-posed for all regimes, effectively removing the high Mach number shock structure singularity.« less

Harmonic Chain with Velocity Flips: Thermalization and Kinetic Theory

NASA Astrophysics Data System (ADS)

Lukkarinen, Jani; Marcozzi, Matteo; Nota, Alessia

2016-12-01

We consider the detailed structure of correlations in harmonic chains with pinning and a bulk velocity flip noise during the heat relaxation phase which occurs on diffusive time scales, for t=O(L^2) where L is the chain length. It has been shown earlier that for non-degenerate harmonic interactions these systems thermalize, and the dominant part of the correlations is given by local thermal equilibrium determined by a temperature profile which satisfies a linear heat equation. Here we are concerned with two new aspects about the thermalization process: the first order corrections in 1 / L to the local equilibrium correlations and the applicability of kinetic theory to study the relaxation process. Employing previously derived explicit uniform estimates for the temperature profile, we first derive an explicit form for the first order corrections to the particle position-momentum correlations. By suitably revising the definition of the Wigner transform and the kinetic scaling limit we derive a phonon Boltzmann equation whose predictions agree with the explicit computation. Comparing the two results, the corrections can be understood as arising from two different sources: a current-related term and a correction to the position-position correlations related to spatial changes in the phonon eigenbasis.

The cosmic ray energy spectrum in the range 1016-1018 eV measured by KASCADE-Grande

NASA Astrophysics Data System (ADS)

Bertaina, M.; Apel, W. D.; Arteaga-Velázquez, J. C.; Bekk, K.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Buchholz, P.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Engel, R.; Engler, J.; Finger, M.; Fuhrmann, D.; Ghia, P. L.; Gils, H. J.; Glasstetter, R.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Kickelbick, D.; Klages, H. O.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Mayer, H. J.; Melissas, M.; Milke, J.; Mitrica, B.; Morello, C.; Navarra, G.; Nehls, S.; Oehlschläger, J.; Ostapchenko, S.; Over, S.; Palmieri, N.; Petcu, M.; Pierog, T.; Rebel, H.; Roth, M.; Schieler, H.; Schröder, F.; Sima, O.; Toma, G.; Trinchero, G. C.; Ulrich, H.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.

2011-06-01

The KASCADE-Grande experiment, located at Campus North of the Karlsruhe Institute of Technology (Germany) is a multi-component extensive air-shower experiment devoted to the study of cosmic rays and their interactions at primary energies 1014-1018 eV. One of the main goals of the experiment is the measurement of the all particle energy spectrum in the 1016-1018 eV range, i.e. extending the range accessible by KASCADE alone. The Grande detector samples the charged component (Nch) of the air shower while the original KASCADE array provides in addition a measurement of the muon component (Nμ). The combined information of Nch and Nμ is used to estimate the energy on an event-by-event basis and to derive the all-particle energy spectrum. Since the calibration of the observables in terms of the primary energy depends on Monte Carlo simulations, three different methods with partially different sources of uncertainties, have been considered and compared to each other to derive the systematics on the energy spectrum. The different methods employed to derive the spectrum and their uncertainties, as well as the implications of the obtained result, are discussed in detail.

Stem cells for cardiac repair: an introduction

PubMed Central

du Pré, Bastiaan C; Doevendans, Pieter A; van Laake, Linda W

2013-01-01

Cardiovascular disease is a major cause of morbidity and mortality throughout the world. Most cardiovascular diseases, such as ischemic heart disease and cardiomyopathy, are associated with loss of functional cardiomyocytes. Unfortunately, the heart has a limited regenerative capacity and is not able to replace these cardiomyocytes once lost. In recent years, stem cells have been put forward as a potential source for cardiac regeneration. Pre-clinical studies that use stem cell-derived cardiac cells show promising results. The mechanisms, though, are not well understood, results have been variable, sometimes transient in the long term, and often without a mechanistic explanation. There are still several major hurdles to be taken. Stem cell-derived cardiac cells should resemble original cardiac cell types and be able to integrate in the damaged heart. Integration requires administration of stem cell-derived cardiac cells at the right time using the right mode of delivery. Once delivered, transplanted cells need vascularization, electrophysiological coupling with the injured heart, and prevention of immunological rejection. Finally, stem cell therapy needs to be safe, reproducible, and affordable. In this review, we will give an introduction to the principles of stem cell based cardiac repair. PMID:23888179

Effect of animal products and extracts on wound healing promotion in topical applications: a review.

PubMed

Napavichayanun, Supamas; Aramwit, Pornanong

2017-06-01

Wound healing is a natural process of body reaction to repair itself after injury. Nonetheless, many internal and external factors such as aging, comorbidity, stress, smoking, alcohol drinking, infections, malnutrition, or wound environment significantly affect the quality and speed of wound healing. The unsuitable conditions may delay wound healing process and cause chronic wound or scar formation. Therefore, many researches have attempted to search for agents that can accelerate wound healing with safety and biocompatibility to human body. Widely studied wound healing agents are those derived from either natural sources including plants and animals or chemical synthesis. The natural products seem to be safer and more biocompatible to human tissue. This review paper demonstrated various kinds of the animal-derived products including chitosan, collagen, honey, anabolic steroids, silk sericin, peptides, and proteoglycan in term of mechanisms of action, advantages, and disadvantages when applied as wound healing accelerator. The benefits of these animal-derived products are wound healing promotion, anti-inflammatory, antimicrobial activity, moisturizing effect, biocompatibility, and safety. However, the drawbacks such as allergy, low stability, batch-to-batch variability, and high extraction and purification costs could not be avoided in some products.

Quantifying monthly to decadal subsidence and assessing collapse potential near the Wink sinkholes, west Texas, using airborne lidar, radar interferometry, and microgravity

NASA Astrophysics Data System (ADS)

Paine, J. G.; Collins, E.; Yang, D.; Andrews, J. R.; Averett, A.; Caudle, T.; Saylam, K.

2014-12-01

We are using airborne lidar and satellite-based radar interferometry (InSAR) to quantify short-term (months to years) and longer-term (decades) subsidence in the area surrounding two large (100- to 200-m diameter) sinkholes that formed above Permian bedded salt in 1980 and 2002 in the Wink area, west Texas. Radar interferograms constructed from synthetic aperture radar data acquired between 2008 and 2011 with the ALOS PALSAR L-band satellite-borne instrument reveal local areas that are subsiding at rates that reach a few cm per month. Subsiding areas identified on radar interferograms enable labor-intensive ground investigations (such as microgravity surveys) to focus on areas where subsidence is occurring and shallow-source mass deficits might exist that could be sites of future subsidence or collapse. Longer-term elevation changes are being quantified by comparing digital elevation models (DEMs) constructed from high-resolution airborne lidar data acquired over a 32-km2 area in 2013 with older, lower-resolution DEMs constructed from data acquired during the NASA- and NGA-sponsored Shuttle Radar Topographic Mission in February 2000 and from USGS aerial photogrammetry-derived topographic data from the 1960s. Total subsidence reaches more than 10 m over 45 years in some areas. Maximum rates of subsidence measured on annual (from InSAR) and decadal (from lidar) time scales are about 0.25 m/yr. In addition to showing the extent and magnitude of subsidence at the 1980 and 2002 sinkholes, comparison of the 2013 lidar-derived DEM with the 1960s photogrammetry-derived DEM revealed other locations that have undergone significant (more than 1 m) elevation change since the 1960s, but show no evidence of recent (2008 to 2011) ground motion from satellite radar interferograms. Regional coverage obtained by radar interferometry and local coverage obtained with airborne lidar show that areas of measurable subsidence are all within a few km of the 1980 and 2002 sinkholes.

Systematically biological prioritizing remediation sites based on datasets of biological investigations and heavy metals in soil

NASA Astrophysics Data System (ADS)

Lin, Wei-Chih; Lin, Yu-Pin; Anthony, Johnathen

2015-04-01

Heavy metal pollution has adverse effects on not only the focal invertebrate species of this study, such as reduction in pupa weight and increased larval mortality, but also on the higher trophic level organisms which feed on them, either directly or indirectly, through the process of biomagnification. Despite this, few studies regarding remediation prioritization take species distribution or biological conservation priorities into consideration. This study develops a novel approach for delineating sites which are both contaminated by any of 5 readily bioaccumulated heavy metal soil contaminants and are of high ecological importance for the highly mobile, low trophic level focal species. The conservation priority of each site was based on the projected distributions of 6 moth species simulated via the presence-only maximum entropy species distribution model followed by the subsequent application of a systematic conservation tool. In order to increase the number of available samples, we also integrated crowd-sourced data with professionally-collected data via a novel optimization procedure based on a simulated annealing algorithm. This integration procedure was important since while crowd-sourced data can drastically increase the number of data samples available to ecologists, still the quality or reliability of crowd-sourced data can be called into question, adding yet another source of uncertainty in projecting species distributions. The optimization method screens crowd-sourced data in terms of the environmental variables which correspond to professionally-collected data. The sample distribution data was derived from two different sources, including the EnjoyMoths project in Taiwan (crowd-sourced data) and the Global Biodiversity Information Facility (GBIF) ?eld data (professional data). The distributions of heavy metal concentrations were generated via 1000 iterations of a geostatistical co-simulation approach. The uncertainties in distributions of the heavy metals were then quantified based on the overall consistency between realizations. Finally, Information-Gap Decision Theory (IGDT) was applied to rank the remediation priorities of contaminated sites in terms of both spatial consensus of multiple heavy metal realizations and the priority of specific conservation areas. Our results show that the crowd-sourced optimization algorithm developed in this study is effective at selecting suitable data from crowd-sourced data. By using this technique the available sample data increased to a total number of 96, 162, 72, 62, 69 and 62 or, that is, 2.6, 1.6, 2.5, 1.6, 1.2 and 1.8 times that originally available through the GBIF professionally-assembled database. Additionally, for all species considered the performance of models, in terms of test-AUC values, based on the combination of both data sources exceeded those models which were based on a single data source. Furthermore, the additional optimization-selected data lowered the overall variability, and therefore uncertainty, of model outputs. Based on the projected species distributions, our results revealed that around 30% of high species hotspot areas were also identified as contaminated. The decision-making tool, IGDT, successfully yielded remediation plans in terms of specific ecological value requirements, false positive tolerance rates of contaminated areas, and expected decision robustness. The proposed approach can be applied both to identify high conservation priority sites contaminated by heavy metals, based on the combination of screened crowd-sourced and professionally-collected data, and in making robust remediation decisions.

Two-relaxation-time lattice Boltzmann method for the anisotropic dispersive Henry problem

NASA Astrophysics Data System (ADS)

Servan-Camas, Borja; Tsai, Frank T.-C.

2010-02-01

This study develops a lattice Boltzmann method (LBM) with a two-relaxation-time collision operator (TRT) to cope with anisotropic heterogeneous hydraulic conductivity and anisotropic velocity-dependent hydrodynamic dispersion in the saltwater intrusion problem. The directional-speed-of-sound technique is further developed to address anisotropic hydraulic conductivity and dispersion tensors. Forcing terms are introduced in the LBM to correct numerical errors that arise during the recovery procedure and to describe the sink/source terms in the flow and transport equations. In order to facilitate the LBM implementation, the forcing terms are combined with the equilibrium distribution functions (EDFs) to create pseudo-EDFs. This study performs linear stability analysis and derives LBM stability domains to solve the anisotropic advection-dispersion equation. The stability domains are used to select the time step at which the lattice Boltzmann method provides stable solutions to the numerical examples. The LBM was implemented for the anisotropic dispersive Henry problem with high ratios of longitudinal to transverse dispersivities, and the results compared well to the solutions in the work of Abarca et al. (2007).

Higher order relativistic galaxy number counts: dominating terms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nielsen, Jeppe TrØst; Durrer, Ruth, E-mail: Jeppe.Trost@nbi.dk, E-mail: Ruth.Durrer@unige.ch

2017-03-01

We review the number counts to second order concentrating on the terms which dominate on sub horizon scales. We re-derive the result for these terms and compare it with the different versions found in the literature. We generalize our derivation to higher order terms, especially the third order number counts which are needed to compute the 1-loop contribution to the power spectrum.

Modeling mesoscale eddies

NASA Astrophysics Data System (ADS)

Canuto, V. M.; Dubovikov, M. S.

Mesoscale eddies are not resolved in coarse resolution ocean models and must be modeled. They affect both mean momentum and scalars. At present, no generally accepted model exists for the former; in the latter case, mesoscales are modeled with a bolus velocity u∗ to represent a sink of mean potential energy. However, comparison of u∗(model) vs. u∗ (eddy resolving code, [J. Phys. Ocean. 29 (1999) 2442]) has shown that u∗(model) is incomplete and that additional terms, "unrelated to thickness source or sinks", are required. Thus far, no form of the additional terms has been suggested. To describe mesoscale eddies, we employ the Navier-Stokes and scalar equations and a turbulence model to treat the non-linear interactions. We then show that the problem reduces to an eigenvalue problem for the mesoscale Bernoulli potential. The solution, which we derive in analytic form, is used to construct the momentum and thickness fluxes. In the latter case, the bolus velocity u∗ is found to contain two types of terms: the first type entails the gradient of the mean potential vorticity and represents a positive contribution to the production of mesoscale potential energy; the second type of terms, which is new, entails the velocity of the mean flow and represents a negative contribution to the production of mesoscale potential energy, or equivalently, a backscatter process whereby a fraction of the mesoscale potential energy is returned to the original reservoir of mean potential energy. This type of terms satisfies the physical description of the additional terms given by [J. Phys. Ocean. 29 (1999) 2442]. The mesoscale flux that enters the momentum equations is also contributed by two types of terms of the same physical nature as those entering the thickness flux. The potential vorticity flux is also shown to contain two types of terms: the first is of the gradient-type while the other terms entail the velocity of the mean flow. An expression is derived for the mesoscale diffusivity κM and for the mesoscale kinetic energy K in terms of the large-scale fields. The predicted κM( z) agrees with that of heuristic models. The complete mesoscale model in isopycnal coordinates is presented in Appendix D and can be used in coarse resolution ocean global circulation models.

A novel derivation of the boundary term for the action in Lanczos-Lovelock gravity

NASA Astrophysics Data System (ADS)

Chakraborty, Sumanta; Parattu, Krishnamohan; Padmanabhan, T.

2017-09-01

We present a novel derivation of the boundary term for the action in Lanczos-Lovelock gravity, starting from the boundary contribution in the variation of the Lanczos-Lovelock action. The derivation presented here is straightforward, i.e., one starts from the Lanczos-Lovelock action principle and the action itself dictates the boundary structure and hence the boundary term one needs to add to the action to make it well-posed. It also gives the full structure of the contribution at the boundary of the complete action, enabling us to read off the degrees of freedom to be fixed at the boundary, their corresponding conjugate momenta and the total derivative contribution on the boundary. We also provide a separate derivation of the Gauss-Bonnet case.

Radiological analysis of plutonium glass batches with natural/enriched boron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rainisch, R.

2000-06-22

The disposition of surplus plutonium inventories by the US Department of Energy (DOE) includes the immobilization of certain plutonium materials in a borosilicate glass matrix, also referred to as vitrification. This paper addresses source terms of plutonium masses immobilized in a borosilicate glass matrix where the glass components include both natural boron and enriched boron. The calculated source terms pertain to neutron and gamma source strength (particles per second), and source spectrum changes. The calculated source terms corresponding to natural boron and enriched boron are compared to determine the benefits (decrease in radiation source terms) for to the use ofmore » enriched boron. The analysis of plutonium glass source terms shows that a large component of the neutron source terms is due to (a, n) reactions. The Americium-241 and plutonium present in the glass emit alpha particles (a). These alpha particles interact with low-Z nuclides like B-11, B-10, and O-17 in the glass to produce neutrons. The low-Z nuclides are referred to as target particles. The reference glass contains 9.4 wt percent B{sub 2}O{sub 3}. Boron-11 was found to strongly support the (a, n) reactions in the glass matrix. B-11 has a natural abundance of over 80 percent. The (a, n) reaction rates for B-10 are lower than for B-11 and the analysis shows that the plutonium glass neutron source terms can be reduced by artificially enriching natural boron with B-10. The natural abundance of B-10 is 19.9 percent. Boron enriched to 96-wt percent B-10 or above can be obtained commercially. Since lower source terms imply lower dose rates to radiation workers handling the plutonium glass materials, it is important to know the achievable decrease in source terms as a result of boron enrichment. Plutonium materials are normally handled in glove boxes with shielded glass windows and the work entails both extremity and whole-body exposures. Lowering the source terms of the plutonium batches will make the handling of these materials less difficult and will reduce radiation exposure to operating workers.« less

Hydrodynamic model for expansion and collisional relaxation of x-ray laser-excited multi-component nanoplasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saxena, Vikrant, E-mail: vikrant.saxena@desy.de; Hamburg Center for Ultrafast Imaging, Luruper Chaussee 149, 22761 Hamburg; Ziaja, Beata, E-mail: ziaja@mail.desy.de

The irradiation of an atomic cluster with a femtosecond x-ray free-electron laser pulse results in a nanoplasma formation. This typically occurs within a few hundred femtoseconds. By this time the x-ray pulse is over, and the direct photoinduced processes no longer contributing. All created electrons within the nanoplasma are thermalized. The nanoplasma thus formed is a mixture of atoms, electrons, and ions of various charges. While expanding, it is undergoing electron impact ionization and three-body recombination. Below we present a hydrodynamic model to describe the dynamics of such multi-component nanoplasmas. The model equations are derived by taking the moments ofmore » the corresponding Boltzmann kinetic equations. We include the equations obtained, together with the source terms due to electron impact ionization and three-body recombination, in our hydrodynamic solver. Model predictions for a test case, expanding spherical Ar nanoplasma, are obtained. With this model, we complete the two-step approach to simulate x-ray created nanoplasmas, enabling computationally efficient simulations of their picosecond dynamics. Moreover, the hydrodynamic framework including collisional processes can be easily extended for other source terms and then applied to follow relaxation of any finite non-isothermal multi-component nanoplasma with its components relaxed into local thermodynamic equilibrium.« less

Rapid discrimination of Herba Cistanches by multi-step infrared macro-fingerprinting combined with soft independent modeling of class analogy (SIMCA)

NASA Astrophysics Data System (ADS)

Xu, Changhua; Jia, Xiaoguang; Xu, Rong; Wang, Yang; Zhou, Qun; Sun, Suqin

2013-10-01

Herba Cistanche, an important Chinese herbal medicine, has common four species, Cistanche deserticola (CD), Cistanche tubulosa (CT), Cistanche salsa (CS) and Cistanche sinensis (CSN) which have been frequent mixed used. To clarify the sources of Herba Cistanches and ensure the clinical efficacy and safety, a method combing IR macro-fingerprinting with statistical pattern recognition was developed to analyze and discriminate the four species of Herba Cistanche. By comparing FT-IR, second derivative spectral fingerprints via group-peak matching, the similarity to CD and total saccharides (TS) followed an increasing sequence, CT < CSN < CS < CD, whereas that to total glycosides (TG) followed a decreasing order, CT > CSN > CS > CD. Characteristic fingerprints of their 2D-IR correlation spectra in 1750-1000 cm-1 have confirmed the above findings in a more intuitive way. In terms of sources for phenylethanoid glycosides (PhGs), CT can be an ideal alternative species. However, in terms of using them as a whole, more pharmacological study should be conducted due to the different ratios of their chemical constituents, which is also applicable to CSN and CS. Moreover, the four species (179 samples) has been objectively classified by SIMCA based on IR macro-fingerprints.

Confronting effective models for deconfinement in dense quark matter with lattice data

NASA Astrophysics Data System (ADS)

Andersen, Jens O.; Brauner, Tomáš; Naylor, William R.

2015-12-01

Ab initio numerical simulations of the thermodynamics of dense quark matter remain a challenge. Apart from the infamous sign problem, lattice methods have to deal with finite volume and discretization effects as well as with the necessity to introduce sources for symmetry-breaking order parameters. We study these artifacts in the Polyakov-loop-extended Nambu-Jona-Lasinio (PNJL) model and compare its predictions to existing lattice data for cold and dense two-color matter with two flavors of Wilson quarks. To achieve even qualitative agreement with lattice data requires the introduction of two novel elements in the model: (i) explicit chiral symmetry breaking in the effective contact four-fermion interaction, referred to as the chiral twist, and (ii) renormalization of the Polyakov loop. The feedback of the dense medium to the gauge sector is modeled by a chemical-potential-dependent scale in the Polyakov-loop potential. In contrast to previously used analytical Ansätze, we determine its dependence on the chemical potential from lattice data for the expectation value of the Polyakov loop. Finally, we propose adding a two-derivative operator to our effective model. This term acts as an additional source of explicit chiral symmetry breaking, mimicking an analogous term in the lattice Wilson action.

Developmental aspects of the interaction between narcissism, self-esteem and object relations.

PubMed

Dare, C; Holder, A

1981-01-01

This paper reviews the history, within psycho-analysis, of narcissism and shows that it cannot be understood as a unitary concept. This is reflected in much of the extensive literature on the topic. The definition of narcissism solely in terms of the libidinal drive cathexis of the self representation is rejected. Instead, narcissism is defined as the sum of the positively-coloured feeling states attached to the self-representation. By pursuing a developmental investigation of narcissistic and opposing phenomena, the multiple sources which contribute to or detract from the overall level of self-esteem are demonstrated. Such an investigation clarifies the close relationship between the concepts of self-esteem, well-being and narcissism, and differentiating definitions are put forward. The term 'counter-narcissistic' is introduced to denote the negative contributions to self-esteem which detract from the narcissistic input. The interplay between the contributions to the overall quality of self-esteem, deriving on the one hand from somatic and instinctual drive sources, and on the other from object relationships, exemplifies the multiple origins of its qualities at any one time. This interplay is pursued through the sequential developmental phases from infancy to the oedipal level in order to show the complex epigenesis of narcissism, counter-narcissism and self-esteem.

Macroscopic modeling for heat and water vapor transfer in dry snow by homogenization.

PubMed

Calonne, Neige; Geindreau, Christian; Flin, Frédéric

2014-11-26

Dry snow metamorphism, involved in several topics related to cryospheric sciences, is mainly linked to heat and water vapor transfers through snow including sublimation and deposition at the ice-pore interface. In this paper, the macroscopic equivalent modeling of heat and water vapor transfers through a snow layer was derived from the physics at the pore scale using the homogenization of multiple scale expansions. The microscopic phenomena under consideration are heat conduction, vapor diffusion, sublimation, and deposition. The obtained macroscopic equivalent model is described by two coupled transient diffusion equations including a source term arising from phase change at the pore scale. By dimensional analysis, it was shown that the influence of such source terms on the overall transfers can generally not be neglected, except typically under small temperature gradients. The precision and the robustness of the proposed macroscopic modeling were illustrated through 2D numerical simulations. Finally, the effective vapor diffusion tensor arising in the macroscopic modeling was computed on 3D images of snow. The self-consistent formula offers a good estimate of the effective diffusion coefficient with respect to the snow density, within an average relative error of 10%. Our results confirm recent work that the effective vapor diffusion is not enhanced in snow.

Anticancer agents derived from natural cinnamic acids.

PubMed

Su, Ping; Shi, Yaling; Wang, Jinfeng; Shen, Xiuxiu; Zhang, Jie

2015-01-01

Cancer is the most dangerous disease that causes deaths all over the world. Natural products have afforded a rich source of drugs in a number of therapeutic fields including anticancer agents. Many significant drugs have been derived from natural sources by structural optimization of natural products. Cinnamic acid has gained great interest due to its antiproliferative, antioxidant, antiangiogenic and antitumorigenic potency. Currently it has been observed that cinnamic acid and its analogs such as caffeic acid, sinapic acid, ferulic acid, and isoferulic acid display various pharmacological activities, such as immunomodulation, anti-inflammation, anticancer and antioxidant. They have served to be the major sources of potential leading anticancer compounds. In this review, we focus on the anticancer potency of cinnamic acid derivatives and novel strategies to design these derivatives. We hope this review will be useful for researchers who are interested in developing anticancer agents.

The experience of mathematical beauty and its neural correlates

PubMed Central

Zeki, Semir; Romaya, John Paul; Benincasa, Dionigi M. T.; Atiyah, Michael F.

2014-01-01

Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC), as the experience of beauty derived from other sources. PMID:24592230

The potential of biodiesel with improved properties to an alternative energy mix

USDA-ARS?s Scientific Manuscript database

Fuels derived from renewable biological sources (biomass) are prominent among the sustainable energy sources. Biodiesel, the mono-alkyl esters of vegetable oils or animal fats, is one of the significant biomass-derived fuels. It is obtained from vegetable oils or other triacylglycerol feedstocks b...

Cell supermarket: Adipose tissue as a source of stem cells

USDA-ARS?s Scientific Manuscript database

Adipose tissue is derived from numerous sources, and in recent years has been shown to provide numerous cells from what seemingly was a population of homogeneous adipocytes. Considering the types of cells that adipose tissue-derived cells may form, these cells may be useful in a variety of clinical ...

Petrology and geochemistry of the Tasse mantle xenoliths of the Canadian Cordillera: A record of Archean to Quaternary mantle growth, metasomatism, removal, and melting

NASA Astrophysics Data System (ADS)

Polat, Ali; Frei, Robert; Longstaffe, Fred J.; Thorkelson, Derek J.; Friedman, Eyal

2018-07-01

Mantle xenoliths hosted by the Quaternary Tasse alkaline basalts in the Canadian Cordillera, southeastern British Columbia, are mostly spinel lherzolite originating from subcontinental lithospheric mantle. The xenoliths contain abundant feldspar veins, melt pockets and spongy clinopyroxene, recording extensive alkaline metasomatism and partial melting. Feldspar occurs as veins and interstitial crystal in melt pockets. Melt pockets occur mainly at triple junctions, along grain boundaries, and consist mainly of olivine, cpx, opx and spinel surrounded by interstitial feldspar. The Nd, Sr and Pb isotopic compositions of the xenoliths indicate that their sources are characterized by variable mixtures of depleted MORB mantle and EM1 and EM2 mantle components. Large variations in εNd values (-8.2 to +9.6) and Nd depleted mantle model ages (TDM = 66 to 3380 Ma) are consistent with multiple sources and melt extraction events, and long-term (>3300 Ma) isolation of some source regions from the convecting mantle. Samples with Archean and Paleoproterozoic Nd model ages are interpreted as either have been derived from relict Laurentian mantle pieces beneath the Cordillera or have been eroded from the root of the Laurentian craton to the east and transported to the base of the Cordilleran lithosphere by edge-driven convection currents. The oxygen isotope compositions of the xenoliths (average δ18O = +5.1 ± 0.5‰) are similar to those of depleted mantle. The average δ18O values of olivine (+5.0 ± 0.2‰), opx (+5.9 ± 0.6‰), cpx (+6.0 ± 0.6‰) and spinel (+4.5 ± 0.2‰) are similar to mantle values. Large fractionations for olivine-opx, olivine-cpx and opx-cpx pairs, however, reflect disequilibrium stemming from metasomatism and partial melting. Whole-rock trace element, Nd, Sr, Pb and O isotope compositions of the xenoliths and host alkaline basalts indicate different mantle sources for these two suites of rocks. The xenoliths were derived from shallow lithospheric sources, whereas the alkaline basalts originated from a deeper asthenospheric mantle source.

Comparative analysis of rat mesenchymal stem cells derived from slow and fast skeletal muscle in vitro.

PubMed

Okumachi, Etsuko; Lee, Sang Yang; Niikura, Takahiro; Iwakura, Takashi; Dogaki, Yoshihiro; Waki, Takahiro; Takahara, Shunsuke; Ueha, Takeshi; Sakai, Yoshitada; Kuroda, Ryosuke; Kurosaka, Masahiro

2015-03-01

Skeletal muscle comprises different kinds of muscle fibres that can be classified as slow and fast fibres. The purpose of this study was to compare the yield, proliferation, and multi-potentiality of rat mesenchymal stem cells (MSCs) from the tibialis anterior (TA; fast muscle) and soleus (SO; slow muscle) in vitro. The TA and SO muscles were harvested, and isolated cells were plated. After two hours, the cells were washed extensively to remove any cell that did not adhere to the cell culture plate. The adherent cells, namely MSCs, were then cultured. Both types of MSCs were differentiated toward the osteogenic, chondrogenic and adipogenic lineages using lineage specific induction factors. The colony-forming unit fibroblast (CFU-F) assay revealed that the SO contained significantly higher quantities of MSCs than the TA. The self-renewal capacity of MSCs derived from the TA was significantly higher at later passages (passage 9-11). Both types of MSCs exhibited similar cell surface antigens to bone marrow (BM)-derived MSCs and were positive for CD29, CD44, and CD90 and negative for CD11b, CD34, and CD45. TA-derived MSCs were superior in terms of osteogenic differentiation capacity, but there was no significant difference in chondrogenic and adipogenic differentiation capacity. Our results demonstrated significant differences in the properties of muscle-derived MSCs from different muscle types (i.e. fast or slow muscles). The greater expandability and osteogenic differentiation ability of TA-derived MSCs suggests that fast muscle may be a better source for generating large numbers of MSCs for bone regeneration.

Non-canonical Wnt Signaling Enhances differentiation of Sca1+/c-kit+ Adipose-derived Murine Stromal Vascular Cells into Spontaneously Beating Cardiac Myocytes

PubMed Central

Palpant, Nathan J.; Yasuda, So-ichiro; MacDougald, Ormond; Metzger, Joseph M.

2007-01-01

Recent reports have described a stem cell population termed stromal vascular cells (SVCs) derived from the stromal vascular fraction of adipose tissue, which are capable of intrinsic differentiation into spontaneously beating cardiomyocytes in vitro. The objective of this study was to further define the cardiac lineage differentiation potential of SVCs in vitro and to derive methods for enriching SVC-derived beating cardiac myocytes. SVCs were isolated from the stromal vascular fraction of murine adipose tissue. Cells were cultured in methylcellulose-based murine stem cell media. Analysis of SVC-derived beating myocytes included Western blot, and calcium imaging. Enrichment of acutely isolated SVCs was carried out using antibody tagged magnetic nanoparticles, and pharmacologic manipulation of Wnt and cytokine signaling. Under initial media conditions, spontaneously beating SVCs expressed both cardiac developmental and adult protein isoforms. Functionally, this specialized population can spontaneously contract and pace under field stimulation, and shows the presence of coordinated calcium transients. Importantly, this study provides evidence for two independent mechanisms of enriching the cardiac differentiation of SVCs. First, this study shows that differentiation of SVCs into cardiac myocytes is augmented by non-canonical Wnt agonists, canonical Wnt antagonists, and cytokines. Second, SVCs capable of cardiac lineage differentiation can be enriched by selection for stem cell-specific membrane markers Sca1 and c-kit. Adipose-derived SVCs are a unique population of stem cells that show evidence of cardiac lineage development making them a potential source for stem cell-based cardiac regeneration studies. PMID:17706246

Digestive Enzyme Supplementation in Gastrointestinal Diseases.

PubMed

Ianiro, Gianluca; Pecere, Silvia; Giorgio, Valentina; Gasbarrini, Antonio; Cammarota, Giovanni

2016-01-01

Digestive enzymes are able to break down proteins and carbohydrates and lipids, and their supplementation may play a role in the management of digestive disorders, from lactose intolerance to cystic fibrosis. To date, several formulations of digestive enzymes are available on the market, being different each other in terms of enzyme type, source and origin, and dosage. This review, performed through a non-systematic search of the available literature, will provide an overview of the current knowledge of digestive enzyme supplementation in gastrointestinal disorders, discussion of the use of pancreatic enzymes, lactase (β-galactosidase) and conjugated bile acids, and also exploring the future perspective of digestive enzyme supplementation. Currently, the animal-derived enzymes represent an established standard of care, however the growing study of plant-based and microbe-derived enzymes offers great promise in the advancement of digestive enzyme therapy. New frontiers of enzyme replacement are being evaluated also in the treatment of diseases not specifically related to enzyme deficiency, whereas the combination of different enzymes might constitute an intriguing therapeutic option in the future.

Avoidance of singularities in asymptotically safe Quantum Einstein Gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kofinas, Georgios; Zarikas, Vasilios; Department of Physics, Aristotle University of Thessaloniki,54124 Thessaloniki

2015-10-30

New general spherically symmetric solutions have been derived with a cosmological “constant” Λ as a source. This Λ term is not constant but it satisfies the properties of the asymptotically safe gravity at the ultraviolet fixed point. The importance of these solutions comes from the fact that they may describe the near to the centre region of black hole spacetimes as this is modified by the Renormalization Group scaling behaviour of the fields. The consistent set of field equations which respect the Bianchi identities is derived and solved. One of the solutions (with conventional sign of temporal-radial metric components) ismore » timelike geodesically complete, and although there is still a curvature divergent origin, this is never approachable by an infalling massive particle which is reflected at a finite distance due to the repulsive origin. Another family of solutions (of both signatures) range from a finite radius outwards, they cannot be extended to the centre of spherical symmetry, and the curvature invariants are finite at the minimum radius.« less

Avoidance of singularities in asymptotically safe Quantum Einstein Gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kofinas, Georgios; Zarikas, Vasilios, E-mail: gkofinas@aegean.gr, E-mail: vzarikas@teilam.gr

2015-10-01

New general spherically symmetric solutions have been derived with a cosmological ''constant'' Λ as a source. This Λ term is not constant but it satisfies the properties of the asymptotically safe gravity at the ultraviolet fixed point. The importance of these solutions comes from the fact that they may describe the near to the centre region of black hole spacetimes as this is modified by the Renormalization Group scaling behaviour of the fields. The consistent set of field equations which respect the Bianchi identities is derived and solved. One of the solutions (with conventional sign of temporal-radial metric components) ismore » timelike geodesically complete, and although there is still a curvature divergent origin, this is never approachable by an infalling massive particle which is reflected at a finite distance due to the repulsive origin. Another family of solutions (of both signatures) range from a finite radius outwards, they cannot be extended to the centre of spherical symmetry, and the curvature invariants are finite at the minimum radius.« less

On the geomagnetic jerk of 1969

NASA Technical Reports Server (NTRS)

Mcleod, M. G.

1985-01-01

Courtillot et al. (1978) have first reported a sudden change in the slope of the first time derivatives of the geomagnetic field components which occurred around 1970. It was found that the change took place in a large part of the northern hemisphere. Malin and Hodder (1982) reported on studies which were conducted to determine whether this 1970 step change in the second time derivative of the geomagnetic field components, which they termed a geomagnetic 'jerk', was of internal or external origin. It was concluded that internal sources can give rise to changes in secular variation on time scales as short as one or two years and that these were the major factor in the geomagnetic jerk which occurred around 1970. The present paper provides new supporting evidence for the existence of a worldwide geomagnetic jerk, its (average) time of occurrence, and its internal nature. New estimates are given of the spherical harmonic coefficients of the jerk and of the pre-1969 and post-1969 secular acceleration.

A time-domain Kirchhoff formula for the convective acoustic wave equation

NASA Astrophysics Data System (ADS)

Ghorbaniasl, Ghader; Siozos-Rousoulis, Leonidas; Lacor, Chris

2016-03-01

Kirchhoff's integral method allows propagated sound to be predicted, based on the pressure and its derivatives in time and space obtained on a data surface located in the linear flow region. Kirchhoff's formula for noise prediction from high-speed rotors and propellers suffers from the limitation of the observer located in uniform flow, thus requiring an extension to arbitrarily moving media. This paper presents a Kirchhoff formulation for moving surfaces in a uniform moving medium of arbitrary configuration. First, the convective wave equation is derived in a moving frame, based on the generalized functions theory. The Kirchhoff formula is then obtained for moving surfaces in the time domain. The formula has a similar form to the Kirchhoff formulation for moving surfaces of Farassat and Myers, with the presence of additional terms owing to the moving medium effect. The equation explicitly accounts for the influence of mean flow and angle of attack on the radiated noise. The formula is verified by analytical cases of a monopole source located in a moving medium.

Can Twitter Be a Source of Information on Allergy? Correlation of Pollen Counts with Tweets Reporting Symptoms of Allergic Rhinoconjunctivitis and Names of Antihistamine Drugs.

PubMed

Gesualdo, Francesco; Stilo, Giovanni; D'Ambrosio, Angelo; Carloni, Emanuela; Pandolfi, Elisabetta; Velardi, Paola; Fiocchi, Alessandro; Tozzi, Alberto E

2015-01-01

Pollen forecasts are in use everywhere to inform therapeutic decisions for patients with allergic rhinoconjunctivitis (ARC). We exploited data derived from Twitter in order to identify tweets reporting a combination of symptoms consistent with a case definition of ARC and those reporting the name of an antihistamine drug. In order to increase the sensitivity of the system, we applied an algorithm aimed at automatically identifying jargon expressions related to medical terms. We compared weekly Twitter trends with National Allergy Bureau weekly pollen counts derived from US stations, and found a high correlation of the sum of the total pollen counts from each stations with tweets reporting ARC symptoms (Pearson's correlation coefficient: 0.95) and with tweets reporting antihistamine drug names (Pearson's correlation coefficient: 0.93). Longitude and latitude of the pollen stations affected the strength of the correlation. Twitter and other social networks may play a role in allergic disease surveillance and in signaling drug consumptions trends.

System description for DART (Decision Analysis for Remediation Technologies)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nonte, J.; Bolander, T.; Nickelson, D.

1997-09-01

DART is a computer aided system populated with influence models to determine quantitative benefits derived by matching requirements and technologies. The DART database is populated with data from over 900 DOE sites from 10 Field Offices. These sites are either source terms, such as buried waste pits, or soil or groundwater contaminated plumes. The data, traceable to published documents, consists of site-specific data (contaminants, area, volume, depth, size, remedial action dates, site preferred remedial option), problems (e.g., offsite contaminant plume), and Site Technology Coordinating Group (STCG) need statements (also contained in the Ten-Year Plan). DART uses this data to calculatemore » and derive site priorities, risk rankings, and site specific technology requirements. DART is also populated with over 900 industry and DOE SCFA technologies. Technology capabilities can be used to match technologies to waste sites based on the technology`s capability to meet site requirements and constraints. Queries may be used to access, sort, roll-up, and rank site data. Data roll-ups may be graphically displayed.« less

NGA-West 2 Equations for predicting PGA, PGV, and 5%-Damped PSA for shallow crustal earthquakes

USGS Publications Warehouse

Boore, David M.; Stewart, Jon P.; Seyhan, Emel; Atkinson, Gail M.

2013-01-01

We provide ground-motion prediction equations for computing medians and standard deviations of average horizontal component intensity measures (IMs) for shallow crustal earthquakes in active tectonic regions. The equations were derived from a global database with M 3.0–7.9 events. We derived equations for the primary M- and distance-dependence of the IMs after fixing the VS30-based nonlinear site term from a parallel NGA-West 2 study. We then evaluated additional effects using mixed effects residuals analysis, which revealed no trends with source depth over the M range of interest, indistinct Class 1 and 2 event IMs, and basin depth effects that increase and decrease long-period IMs for depths larger and smaller, respectively, than means from regional VS30-depth relations. Our aleatory variability model captures decreasing between-event variability with M, as well as within-event variability that increases or decreases with M depending on period, increases with distance, and decreases for soft sites.

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.

PubMed

Huebsch, Nathaniel; Loskill, Peter; Mandegar, Mohammad A; Marks, Natalie C; Sheehan, Alice S; Ma, Zhen; Mathur, Anurag; Nguyen, Trieu N; Yoo, Jennie C; Judge, Luke M; Spencer, C Ian; Chukka, Anand C; Russell, Caitlin R; So, Po-Lin; Conklin, Bruce R; Healy, Kevin E

2015-05-01

Contractile motion is the simplest metric of cardiomyocyte health in vitro, but unbiased quantification is challenging. We describe a rapid automated method, requiring only standard video microscopy, to analyze the contractility of human-induced pluripotent stem cell-derived cardiomyocytes (iPS-CM). New algorithms for generating and filtering motion vectors combined with a newly developed isogenic iPSC line harboring genetically encoded calcium indicator, GCaMP6f, allow simultaneous user-independent measurement and analysis of the coupling between calcium flux and contractility. The relative performance of these algorithms, in terms of improving signal to noise, was tested. Applying these algorithms allowed analysis of contractility in iPS-CM cultured over multiple spatial scales from single cells to three-dimensional constructs. This open source software was validated with analysis of isoproterenol response in these cells, and can be applied in future studies comparing the drug responsiveness of iPS-CM cultured in different microenvironments in the context of tissue engineering.

Efficient calculation of cosmological neutrino clustering in the non-linear regime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Archidiacono, Maria; Hannestad, Steen, E-mail: archi@phys.au.dk, E-mail: sth@phys.au.dk

2016-06-01

We study in detail how neutrino perturbations can be followed in linear theory by using only terms up to l =2 in the Boltzmann hierarchy. We provide a new approximation to the third moment and demonstrate that the neutrino power spectrum can be calculated to a precision of better than ∼ 5% for masses up to ∼ 1 eV and k ∼< 10 h /Mpc. The matter power spectrum can be calculated far more precisely and typically at least a factor of a few better than with existing approximations. We then proceed to study how the neutrino power spectrum canmore » be reliably calculated even in the non-linear regime by using the non-linear gravitational potential, sourced by dark matter overdensities, as it is derived from semi-analytic methods based on N -body simulations in the Boltzmann evolution hierarchy. Our results agree extremely well with results derived from N -body simulations that include cold dark matter and neutrinos as independent particles with different properties.« less

On the Computation of Sound by Large-Eddy Simulations

NASA Technical Reports Server (NTRS)

Piomelli, Ugo; Streett, Craig L.; Sarkar, Sutanu

1997-01-01

The effect of the small scales on the source term in Lighthill's acoustic analogy is investigated, with the objective of determining the accuracy of large-eddy simulations when applied to studies of flow-generated sound. The distribution of the turbulent quadrupole is predicted accurately, if models that take into account the trace of the SGS stresses are used. Its spatial distribution is also correct, indicating that the low-wave-number (or frequency) part of the sound spectrum can be predicted well by LES. Filtering, however, removes the small-scale fluctuations that contribute significantly to the higher derivatives in space and time of Lighthill's stress tensor T(sub ij). The rms fluctuations of the filtered derivatives are substantially lower than those of the unfiltered quantities. The small scales, however, are not strongly correlated, and are not expected to contribute significantly to the far-field sound; separate modeling of the subgrid-scale density fluctuations might, however, be required in some configurations.

Evidence from Xenon isotopes for limited mixing between MORB sources and plume sources since 4.45 Ga

NASA Astrophysics Data System (ADS)

Mukhopadhyay, S.

2011-12-01

Xenon isotopes provide unique insights into the sources of volatile material for planet Earth, the degassing of the mantle, and the chemical evolution of the mantle [1-4]. 129Xe is produced from 129I, which has a half-life of 16 Myrs, and 131-136Xe are produced from 244Pu, which has a half-life of 80 Myrs. To a smaller extent, 131-136Xe are also produced from 238U fission. Thus, ratios of Pu-derived to U-derived fission xenon and 129I-derived to Pu-derived fission xenon constrain the rate and degree of outgassing of a mantle reservoir. Here, I report on the Pu-derived to U-derived fission xenon and Pu/I ratio of the Iceland plume. I then compare the plume observations with the gas rich popping rock from the North Mid Atlantic Ridge that samples the upper mantle [4]. Through step crushing of multiple aliquots of a basalt glass from Iceland, 51 high-precision He, Ne, Ar, and Xe isotopic compositions were generated. Combined He, Ne, and Xe measurements provide unequivocal evidence that the Iceland plume has a lower 129Xe/130Xe ratio than MORBs because it evolved with a I/Xe ratio distinct from the MORB source and not because of recycled atmosphere (which has low 129Xe/130Xe) in the plume source. Since 129I became extinct 80 Myrs after solar system formation, limited mixing between plume and MORB source is a stringent requirement since 4.45 Ga. Of the 51 different isotopic analyses, 42 data points were distinct from the atmospheric 129Xe/130Xe composition at two standard deviations. These 42 data points were utilized to calculate the ratio of Pu- to U-derived fission xenon. The starting composition of terrestrial Xe is a matter of debate. However, for reasonable starting compositions of air, non-radiogenic atmosphere, solar wind, and U-Xe [5-7], the Iceland plume ,on average, has approximately a factor of two higher Pu-derived xenon than the MORB source. These data thus, provide unequivocal evidence that the Iceland plume is less degassed than the MORB source and that the differences must have existed early on because Pu becomes extinct after ~ 400 Myrs. Thus, the Xe isotopic data suggests that differences between plume and MORB sources are the result of different mantle processing rates and not related to the preferential recycling of atmospheric gases into the plume source. Furthermore, if the plumes are derived from the large low shear wave velocity (LLSVPs) provinces at the base of the lower mantle [8], then our results require that LLSVPs are not made of solely recycled material. Rather, primitive material must constitute some fraction of the LLSVPs, and LLSVPs are ancient, having persisted through most of Earth's history. [1] Holland and Ballentine, Nature, 2006. [2] Yokochi and Marty, EPSL, 2004. [3] Coltice et al., Chem Geol., 2009. [4] Moriera et al., Science, 1998. [5] Caffee et al., Science, 1998. [6] Kunz et al., Science 1998. [7] Pepin and Porcelli, EPSL, 2006. [8] Torsvik et al., Nature, 2010.

The influence of initial conditions on dispersion and reactions

NASA Astrophysics Data System (ADS)

Wood, B. D.

2016-12-01

In various generalizations of the reaction-dispersion problem, researchers have developed frameworks in which the apparent dispersion coefficient can be negative. Such dispersion coefficients raise several difficult questions. Most importantly, the presence of a negative dispersion coefficient at the macroscale leads to a macroscale representation that illustrates an apparent decrease in entropy with increasing time; this, then, appears to be in violation of basic thermodynamic principles. In addition, the proposition of a negative dispersion coefficient leads to an inherently ill-posed mathematical transport equation. The ill-posedness of the problem arises because there is no unique initial condition that corresponds to a later-time concentration distribution (assuming that if discontinuous initial conditions are allowed). In this presentation, we explain how the phenomena of negative dispersion coefficients actually arise because the governing differential equation for early times should, when derived correctly, incorporate a term that depends upon the initial and boundary conditions. The process of reactions introduces a similar phenomena, where the structure of the initial and boundary condition influences the form of the macroscopic balance equations. When upscaling is done properly, new equations are developed that include source terms that are not present in the classical (late-time) reaction-dispersion equation. These source terms depend upon the structure of the initial condition of the reacting species, and they decrease exponentially in time (thus, they converge to the conventional equations at asymptotic times). With this formulation, the resulting dispersion tensor is always positive-semi-definite, and the reaction terms directly incorporate information about the state of mixedness of the system. This formulation avoids many of the problems that would be engendered by defining negative-definite dispersion tensors, and properly represents the effective rate of reaction at early times.

On estimating attenuation from the amplitude of the spectrally whitened ambient seismic field

NASA Astrophysics Data System (ADS)

Weemstra, Cornelis; Westra, Willem; Snieder, Roel; Boschi, Lapo

2014-06-01

Measuring attenuation on the basis of interferometric, receiver-receiver surface waves is a non-trivial task: the amplitude, more than the phase, of ensemble-averaged cross-correlations is strongly affected by non-uniformities in the ambient wavefield. In addition, ambient noise data are typically pre-processed in ways that affect the amplitude itself. Some authors have recently attempted to measure attenuation in receiver-receiver cross-correlations obtained after the usual pre-processing of seismic ambient-noise records, including, most notably, spectral whitening. Spectral whitening replaces the cross-spectrum with a unit amplitude spectrum. It is generally assumed that cross-terms have cancelled each other prior to spectral whitening. Cross-terms are peaks in the cross-correlation due to simultaneously acting noise sources, that is, spurious traveltime delays due to constructive interference of signal coming from different sources. Cancellation of these cross-terms is a requirement for the successful retrieval of interferometric receiver-receiver signal and results from ensemble averaging. In practice, ensemble averaging is replaced by integrating over sufficiently long time or averaging over several cross-correlation windows. Contrary to the general assumption, we show in this study that cross-terms are not required to cancel each other prior to spectral whitening, but may also cancel each other after the whitening procedure. Specifically, we derive an analytic approximation for the amplitude difference associated with the reversed order of cancellation and normalization. Our approximation shows that an amplitude decrease results from the reversed order. This decrease is predominantly non-linear at small receiver-receiver distances: at distances smaller than approximately two wavelengths, whitening prior to ensemble averaging causes a significantly stronger decay of the cross-spectrum.

Part 2 of a Computational Study of a Drop-Laden Mixing Layer

NASA Technical Reports Server (NTRS)

Okongo, Nora; Bellan, Josette

2004-01-01

This second of three reports on a computational study of a mixing layer laden with evaporating liquid drops presents the evaluation of Large Eddy Simulation (LES) models. The LES models were evaluated on an existing database that had been generated using Direct Numerical Simulation (DNS). The DNS method and the database are described in the first report of this series, Part 1 of a Computational Study of a Drop-Laden Mixing Layer (NPO-30719), NASA Tech Briefs, Vol. 28, No.7 (July 2004), page 59. The LES equations, which are derived by applying a spatial filter to the DNS set, govern the evolution of the larger scales of the flow and can therefore be solved on a coarser grid. Consistent with the reduction in grid points, the DNS drops would be represented by fewer drops, called computational drops in the LES context. The LES equations contain terms that cannot be directly computed on the coarser grid and that must instead be modeled. Two types of models are necessary: (1) those for the filtered source terms representing the effects of drops on the filtered flow field and (2) those for the sub-grid scale (SGS) fluxes arising from filtering the convective terms in the DNS equations. All of the filtered-sourceterm models that were developed were found to overestimate the filtered source terms. For modeling the SGS fluxes, constant-coefficient Smagorinsky, gradient, and scale-similarity models were assessed and calibrated on the DNS database. The Smagorinsky model correlated poorly with the SGS fluxes, whereas the gradient and scale-similarity models were well correlated with the SGS quantities that they represented.

Brief report: reconstruction of joint hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage.

PubMed

Mizuno, Mitsuru; Kobayashi, Shinji; Takebe, Takanori; Kan, Hiroomi; Yabuki, Yuichiro; Matsuzaki, Takahisa; Yoshikawa, Hiroshi Y; Nakabayashi, Seiichiro; Ik, Lee Jeong; Maegawa, Jiro; Taniguchi, Hideki

2014-03-01

In healthy joints, hyaline cartilage covering the joint surfaces of bones provides cushioning due to its unique mechanical properties. However, because of its limited regenerative capacity, age- and sports-related injuries to this tissue may lead to degenerative arthropathies, prompting researchers to investigate a variety of cell sources. We recently succeeded in isolating human cartilage progenitor cells from ear elastic cartilage. Human cartilage progenitor cells have high chondrogenic and proliferative potential to form elastic cartilage with long-term tissue maintenance. However, it is unknown whether ear-derived cartilage progenitor cells can be used to reconstruct hyaline cartilage, which has different mechanical and histological properties from elastic cartilage. In our efforts to develop foundational technologies for joint hyaline cartilage repair and reconstruction, we conducted this study to obtain an answer to this question. We created an experimental canine model of knee joint cartilage damage, transplanted ear-derived autologous cartilage progenitor cells. The reconstructed cartilage was rich in proteoglycans and showed unique histological characteristics similar to joint hyaline cartilage. In addition, mechanical properties of the reconstructed tissues were higher than those of ear cartilage and equal to those of joint hyaline cartilage. This study suggested that joint hyaline cartilage was reconstructed from ear-derived cartilage progenitor cells. It also demonstrated that ear-derived cartilage progenitor cells, which can be harvested by a minimally invasive method, would be useful for reconstructing joint hyaline cartilage in patients with degenerative arthropathies. © AlphaMed Press.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Ying -Hsuan; Shao, Shu -Heng; Wang, Yifan

We study up to 8-derivative terms in the Coulomb branch effective action of (1,1) little string theory, by collecting results of 4-gluon scattering amplitudes from both perturbative 6D super-Yang-Mills theory up to 4-loop order, and tree-level double scaled little string theory (DSLST). In previous work we have matched the 6-derivative term from the 6D gauge theory to DSLST, indicating that this term is protected on the entire Coulomb branch. The 8-derivative term, on the other hand, is unprotected. In this paper we compute the 8-derivative term by interpolating from the two limits, near the origin and near the infinity onmore » the Coulomb branch, numerically from SU(k) SYM and DSLST respectively, for k=2,3,4,5. We discuss the implication of this result on the UV completion of 6D SYM as well as the strong coupling completion of DSLST. As a result, we also comment on analogous interpolating functions in the Coulomb phase of circle-compactified (2,0) little string theory.« less

Absolute measurement of LDR brachytherapy source emitted power: Instrument design and initial measurements.

PubMed

Malin, Martha J; Palmer, Benjamin R; DeWerd, Larry A

2016-02-01

Energy-based source strength metrics may find use with model-based dose calculation algorithms, but no instruments exist that can measure the energy emitted from low-dose rate (LDR) sources. This work developed a calorimetric technique for measuring the power emitted from encapsulated low-dose rate, photon-emitting brachytherapy sources. This quantity is called emitted power (EP). The measurement methodology, instrument design and performance, and EP measurements made with the calorimeter are presented in this work. A calorimeter operating with a liquid helium thermal sink was developed to measure EP from LDR brachytherapy sources. The calorimeter employed an electrical substitution technique to determine the power emitted from the source. The calorimeter's performance and thermal system were characterized. EP measurements were made using four (125)I sources with air-kerma strengths ranging from 2.3 to 5.6 U and corresponding EPs of 0.39-0.79 μW, respectively. Three Best Medical 2301 sources and one Oncura 6711 source were measured. EP was also computed by converting measured air-kerma strengths to EPs through Monte Carlo-derived conversion factors. The measured EP and derived EPs were compared to determine the accuracy of the calorimeter measurement technique. The calorimeter had a noise floor of 1-3 nW and a repeatability of 30-60 nW. The calorimeter was stable to within 5 nW over a 12 h measurement window. All measured values agreed with derived EPs to within 10%, with three of the four sources agreeing to within 4%. Calorimeter measurements had uncertainties ranging from 2.6% to 4.5% at the k = 1 level. The values of the derived EPs had uncertainties ranging from 2.9% to 3.6% at the k = 1 level. A calorimeter capable of measuring the EP from LDR sources has been developed and validated for (125)I sources with EPs between 0.43 and 0.79 μW.

Towards Seismic Tomography Based Upon Adjoint Methods

NASA Astrophysics Data System (ADS)

Tromp, J.; Liu, Q.; Tape, C.; Maggi, A.

2006-12-01

We outline the theory behind tomographic inversions based on 3D reference models, fully numerical 3D wave propagation, and adjoint methods. Our approach involves computing the Fréchet derivatives for tomographic inversions via the interaction between a forward wavefield, propagating from the source to the receivers, and an `adjoint' wavefield, propagating from the receivers back to the source. The forward wavefield is computed using a spectral-element method (SEM) and a heterogeneous wave-speed model, and stored as synthetic seismograms at particular receivers for which there is data. We specify an objective or misfit function that defines a measure of misfit between data and synthetics. For a given receiver, the differences between the data and the synthetics are time reversed and used as the source of the adjoint wavefield. For each earthquake, the interaction between the regular and adjoint wavefields is used to construct finite-frequency sensitivity kernels, which we call event kernel. These kernels may be thought of as weighted sums of measurement-specific banana-donut kernels, with weights determined by the measurements. The overall sensitivity is simply the sum of event kernels, which defines the misfit kernel. The misfit kernel is multiplied by convenient orthonormal basis functions that are embedded in the SEM code, resulting in the gradient of the misfit function, i.e., the Fréchet derivatives. The misfit kernel is multiplied by convenient orthonormal basis functions that are embedded in the SEM code, resulting in the gradient of the misfit function, i.e., the Fréchet derivatives. A conjugate gradient algorithm is used to iteratively improve the model while reducing the misfit function. Using 2D examples for Rayleigh wave phase-speed maps of southern California, we illustrate the construction of the gradient and the minimization algorithm, and consider various tomographic experiments, including source inversions, structural inversions, and joint source-structure inversions. We also illustrate the characteristics of these 3D finite-frequency kernels based upon adjoint simulations for a variety of global arrivals, e.g., Pdiff, P'P', and SKS, and we illustrate how the approach may be used to investigate body- and surface-wave anisotropy. In adjoint tomography any time segment in which the data and synthetics match reasonably well is suitable for measurement, and this implies a much greater number of phases per seismogram can be used compared to classical tomography in which the sensitivity of the measurements is determined analytically for specific arrivals, e.g., P. We use an automated picking algorithm based upon short-term/long-term averages and strict phase and amplitude anomaly criteria to determine arrivals and time windows suitable for measurement. For shallow global events the algorithm typically identifies of the order of 1000~windows suitable for measurement, whereas for a deep event the number can reach 4000. For southern California earthquakes the number of phases is of the order of 100 for a magnitude 4.0 event and up to 450 for a magnitude 5.0 event. We will show examples of event kernels for both global and regional earthquakes. These event kernels form the basis of adjoint tomography.

Years of life lost and morbidity cases attributable to transportation noise and air pollution: A comparative health risk assessment for Switzerland in 2010.

PubMed

Vienneau, Danielle; Perez, Laura; Schindler, Christian; Lieb, Christoph; Sommer, Heini; Probst-Hensch, Nicole; Künzli, Nino; Röösli, Martin

2015-08-01

There is growing evidence that chronic exposure to transportation related noise and air pollution affects human health. However, health burden to a country of these two pollutants have been rarely compared. As an input for external cost quantification, we estimated the cardiorespiratory health burden from transportation related noise and air pollution in Switzerland, incorporating the most recent findings related to the health effects of noise. Spatially resolved noise and air pollution models for the year 2010 were derived for road, rail and aircraft sources. Average day-evening-night sound level (Lden) and particulate matter (PM10) were selected as indicators, and population-weighted exposures derived by transportation source. Cause-specific exposure-response functions were derived from a meta-analysis for noise and literature review for PM10. Years of life lost (YLL) were calculated using life table methods; population attributable fraction was used for deriving attributable cases for hospitalisations, respiratory illnesses, visits to general practitioners and restricted activity days. The mean population weighted exposure above a threshold of 48dB(A) was 8.74dB(A), 1.89dB(A) and 0.37dB(A) for road, rail and aircraft noise. Corresponding mean exposure contributions were 4.4, 0.54, 0.12μg/m(3) for PM10. We estimated that in 2010 in Switzerland transportation caused 6000 and 14,000 YLL from noise and air pollution exposure, respectively. While there were a total of 8700 cardiorespiratory hospital days attributed to air pollution exposure, estimated burden due to noise alone amounted to 22,500 hospital days. YLL due to transportation related pollution in Switzerland is dominated by air pollution from road traffic, whereas consequences for morbidity and indicators of quality of life are dominated by noise. In terms of total external costs the burden of noise equals that of air pollution. Copyright © 2015 Elsevier GmbH. All rights reserved.

The intensity of segregation of the OH-Isoprene reaction -measurements above the amazon rain forest-

NASA Astrophysics Data System (ADS)

Sörgel, Matthias; Berger, Martina; Dlugi, Ralph; Harder, Hartwig; Kesselmeier, Jürgen; Mallik, Chinmay; Marno, Daniel; Tsokankunku, Anywhere; Wolff, Stefan; Yanez-Serrano, Ana-Maria; Zelger, Michael

2017-04-01

Incomplete mixing (segregation) causes reduced reaction rates compared to laboratory values derived for well mixed conditions. The dominant contribution to atmospheric chemistry is given by the most important oxidizing agent, the OH-radical, which is regarded as the detergent of the atmosphere as it reacts with the majority of atmospheric pollutants and therefore accelerates their removal from the atmosphere. Hence, to understand atmospheric self-cleansing, we need to quantify and understand the budgets (sources and sinks) of OH. Budgets are generally derived by measuring mixing ratios of known source molecules (either primary or recycling) and the total sink for OH of which isoprene is an important part in the pristine rain forest. The production and loss terms are calculated by using the measured mixing ratios and the laboratory derived kinetic values. If reactants are not well mixed their actual reaction rates are lower in the atmosphere than in the laboratory. Therefore, segregation might play a substantial role in quantifying and understanding the derived budgets. We measured OH-radicals, isoprene and other species (O3, NOx, HO2, H2O) with high time resolution (1-10 Hz) shortly above a rain forest canopy (41 m above ground level) at the ATTO (Amazon Tall Tower Observatory) site (02°08'38.8''S, 58°59'59.5''W). The site is characterized by high isoprene (up to 20 ppb) and low NO (50 ppt - 500 ppt). Simultaneous measurements of OH and isoprene with high time resolution (necessary to directly calculate the intensity of segregation) are sparse. To our knowledge this is now the third dataset for OH-isoprene segregation but the first from a tropical rain forest. The results will be compared to modeling results from different environments and the effect of trace gas exchange driven by coherent structures on the intensity of segregation will be evaluated as well.

Cattle-derived microbial input to source water catchments: An experimental assessment of stream crossing modification.

PubMed

Smolders, Andrew; Rolls, Robert J; Ryder, Darren; Watkinson, Andrew; Mackenzie, Mark

2015-06-01

The provision of safe drinking water is a global issue, and animal production is recognized as a significant potential origin of human infectious pathogenic microorganisms within source water catchments. On-farm management can be used to mitigate livestock-derived microbial pollution in source water catchments to reduce the risk of contamination to potable water supplies. We applied a modified Before-After Control Impact (BACI) design to test if restricting the access of livestock to direct contact with streams prevented longitudinal increases in the concentrations of faecal indicator bacteria and suspended solids. Significant longitudinal increases in pollutant concentrations were detected between upstream and downstream reaches of the control crossing, whereas such increases were not detected at the treatment crossing. Therefore, while the crossing upgrade was effective in preventing cattle-derived point source pollution by between 112 and 158%, diffuse source pollution to water supplies from livestock is not ameliorated by this intervention alone. Our findings indicate that stream crossings that prevent direct contact between livestock and waterways provide a simple method for reducing pollutant loads in source water catchments, which ultimately minimises the likelihood of pathogenic microorganisms passing through source water catchments and the drinking water supply system. The efficacy of the catchment as a primary barrier to pathogenic risks to drinking water supplies would be improved with the integration of management interventions that minimise direct contact between livestock and waterways, combined with the mitigation of diffuse sources of livestock-derived faecal matter from farmland runoff to the aquatic environment. Copyright © 2015 Elsevier Ltd. All rights reserved.

Estimation of the clinical and economic consequences of non-compliance with antimicrobial treatment of canine skin infections.

PubMed

Van Vlaenderen, Ilse; Nautrup, Barbara Poulsen; Gasper, Sabina M

2011-05-01

The goal of this study was to estimate the health and economic consequences of non-compliance with oral antimicrobial treatment in dogs with superficial pyoderma, wounds or abscesses in the US. A mathematical model (Markov model) which simulated treatment with long-term injectable cefovecin versus oral amoxicillin/clavulanic acid was developed and accounted for the effect of non-compliance on clinical outcomes and mean total treatment costs per patient. Efficacy parameters considered in the model were derived from clinical studies. Treatment failure due to oral antimicrobial treatment non-compliance was approximated from published data at 13.6%. US cost data for 2009 were derived from public sources. When non-compliance was considered as a cause of treatment failure with oral medication, the long-term injectable antibiotic was more effective than oral comparator (162 versus 158 days without clinical signs). Mean total treatment costs were lower with cefovecin (USD 376.74) versus amoxicillin/clavulanic acid (USD 382.34) in dogs of 25 kg; and cefovecin remained cost-saving up to a body weight of 31 kg. In large dogs, cefovecin was more costly; however, total therapy costs were less than 6% greater than with amoxicillin/clavulanic acid. Accordingly the higher drug and administration costs of the long-term injectable antibiotic were totally or substantially offset when non-compliance was considered as reason for treatment failure with oral medication. The model also allowed for the estimation of the impact of various non-compliance scenarios. Copyright © 2011 Elsevier B.V. All rights reserved.

26 CFR 1.737-3 - Basis adjustments; Recovery rules.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Properties A1, A2, and A3 is long-term, U.S.-source capital gain or loss. The character of gain on Property A4 is long-term, foreign-source capital gain. B contributes Property B, nondepreciable real property...-term, foreign-source capital gain ($3,000 total gain under section 737 × $2,000 net long-term, foreign...

26 CFR 1.737-3 - Basis adjustments; Recovery rules.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Properties A1, A2, and A3 is long-term, U.S.-source capital gain or loss. The character of gain on Property A4 is long-term, foreign-source capital gain. B contributes Property B, nondepreciable real property...-term, foreign-source capital gain ($3,000 total gain under section 737 × $2,000 net long-term, foreign...

26 CFR 1.737-3 - Basis adjustments; Recovery rules.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Properties A1, A2, and A3 is long-term, U.S.-source capital gain or loss. The character of gain on Property A4 is long-term, foreign-source capital gain. B contributes Property B, nondepreciable real property...-term, foreign-source capital gain ($3,000 total gain under section 737 × $2,000 net long-term, foreign...

26 CFR 1.737-3 - Basis adjustments; Recovery rules.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Properties A1, A2, and A3 is long-term, U.S.-source capital gain or loss. The character of gain on Property A4 is long-term, foreign-source capital gain. B contributes Property B, nondepreciable real property...-term, foreign-source capital gain ($3,000 total gain under section 737 × $2,000 net long-term, foreign...

26 CFR 1.737-3 - Basis adjustments; Recovery rules.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Properties A1, A2, and A3 is long-term, U.S.-source capital gain or loss. The character of gain on Property A4 is long-term, foreign-source capital gain. B contributes Property B, nondepreciable real property...-term, foreign-source capital gain ($3,000 total gain under section 737 × $2,000 net long-term, foreign...

Receptivity of the compressible mixing layer

NASA Astrophysics Data System (ADS)

Barone, Matthew F.; Lele, Sanjiva K.

2005-09-01

Receptivity of compressible mixing layers to general source distributions is examined by a combined theoretical/computational approach. The properties of solutions to the adjoint Navier Stokes equations are exploited to derive expressions for receptivity in terms of the local value of the adjoint solution. The result is a description of receptivity for arbitrary small-amplitude mass, momentum, and heat sources in the vicinity of a mixing-layer flow, including the edge-scattering effects due to the presence of a splitter plate of finite width. The adjoint solutions are examined in detail for a Mach 1.2 mixing-layer flow. The near field of the adjoint solution reveals regions of relatively high receptivity to direct forcing within the mixing layer, with receptivity to nearby acoustic sources depending on the source type and position. Receptivity ‘nodes’ are present at certain locations near the splitter plate edge where the flow is not sensitive to forcing. The presence of the nodes is explained by interpretation of the adjoint solution as the superposition of incident and scattered fields. The adjoint solution within the boundary layer upstream of the splitter-plate trailing edge reveals a mechanism for transfer of energy from boundary-layer stability modes to Kelvin Helmholtz modes. Extension of the adjoint solution to the far field using a Kirchhoff surface gives the receptivity of the mixing layer to incident sound from distant sources.

Evaluation of sensor, environment and operational factors impacting the use of multiple sensor constellations for long term resource monitoring

NASA Astrophysics Data System (ADS)

Rengarajan, Rajagopalan

Moderate resolution remote sensing data offers the potential to monitor the long and short term trends in the condition of the Earth's resources at finer spatial scales and over longer time periods. While improved calibration (radiometric and geometric), free access (Landsat, Sentinel, CBERS), and higher level products in reflectance units have made it easier for the science community to derive the biophysical parameters from these remotely sensed data, a number of issues still affect the analysis of multi-temporal datasets. These are primarily due to sources that are inherent in the process of imaging from single or multiple sensors. Some of these undesired or uncompensated sources of variation include variation in the view angles, illumination angles, atmospheric effects, and sensor effects such as Relative Spectral Response (RSR) variation between different sensors. The complex interaction of these sources of variation would make their study extremely difficult if not impossible with real data, and therefore, a simulated analysis approach is used in this study. A synthetic forest canopy is produced using the Digital Imaging and Remote Sensing Image Generation (DIRSIG) model and its measured BRDFs are modeled using the RossLi canopy BRDF model. The simulated BRDF matches the real data to within 2% of the reflectance in the red and the NIR spectral bands studied. The BRDF modeling process is extended to model and characterize the defoliation of a forest, which is used in factor sensitivity studies to estimate the effect of each factor for varying environment and sensor conditions. Finally, a factorial experiment is designed to understand the significance of the sources of variation, and regression based analysis are performed to understand the relative importance of the factors. The design of experiment and the sensitivity analysis conclude that the atmospheric attenuation and variations due to the illumination angles are the dominant sources impacting the at-sensor radiance.